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1. Pan ZG, Wang B: Anaplastic carcinoma of the pancreas associated with a mucinous cystic adenocarcinoma. A case report and review of the literature. JOP; 2007;8(6):775-82
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  • [Title] Anaplastic carcinoma of the pancreas associated with a mucinous cystic adenocarcinoma. A case report and review of the literature.
  • CONTEXT: Anaplastic carcinoma of the pancreas is a rare undifferentiated variant of ductal adenocarcinoma, which commonly displays sarcomatoid spindle-cell and pleomorphic growth patterns.
  • Anaplastic carcinoma of the pancreas associated with mucinous cystic neoplasm has rarely been reported.
  • CASE REPORT: Here we report a unique case of an anaplastic carcinoma of the pancreas in association with a mucinous cystadenocarcinoma in a 70-year-old woman.
  • The anaplastic component of this tumor is predominantly composed of spindle cells and highly pleomorphic cells that mimic a spindle cell sarcoma.
  • Adjacent to the solid anaplastic tumor is a classic mucinous cystadenocarcinoma, which has strong reactivity to mucin 1, CA 19-9, epithelial membrane antigen (EMA), CK19, CK8/18, carcinoembryonic antigen and CK7.
  • CONCLUSION: The anaplastic carcinoma of the pancreas is of epithelial origin with various microscopic features, and the scattered osteoclast-like giant cells in the tumor are reactive cells of histiocytic origin.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17993730.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 15
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2. Wong M, See JY, Sufyan W, Diddapur RK: Splenic infarction. A rare presentation of anaplastic pancreatic carcinoma and a review of the literature. JOP; 2008;9(4):493-8
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  • [Title] Splenic infarction. A rare presentation of anaplastic pancreatic carcinoma and a review of the literature.
  • CONTEXT: Anaplastic carcinoma of the pancreas is a rare variant of ductal adenocarcinoma.
  • CASE REPORT: We report a case of advanced anaplastic carcinoma in a 41-year-old man who presented with splenic infarction.
  • He had a prolonged survival of 16 months from diagnosis.
  • CONCLUSION: Splenic infarction is a most unusual acute presentation of pancreatic carcinoma, which may require emergency tumor resection and splenectomy.
  • [MeSH-major] Abdomen, Acute / etiology. Carcinoma / complications. Carcinoma / pathology. Pancreatic Neoplasms / complications. Pancreatic Neoplasms / pathology. Splenic Infarction / etiology

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  • (PMID = 18648141.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 11
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3. Hakamada K, Miura T, Kimura A, Nara M, Toyoki Y, Narumi S, Sasak M: Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature. World J Gastroenterol; 2008 Jan 7;14(1):132-5
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  • [Title] Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature.
  • Oncogenesis of anaplastic carcinoma of the pancreas is a subject of controversy, because it shows sarcomatous nature with extremely poor prognosis.
  • We herein report an unusual case of anaplastic carcinoma occurring with a recurrent mucinous cystic neoplasm in a 38-year-old female.
  • A 10-cm retroperitoneal cystic mass was pointed out in the first pregnancy and a probable diagnosis of mucinous cystic neoplasm was made in October 2000.
  • A diagnosis of borderline-type mucinous cystic neoplasm with ovarian-like stroma was made.
  • Pathology revealed that the tumor was composed of two different components of borderline-type mucinous cystic neoplasm and anaplastic carcinoma.
  • Although the origin of anaplastic carcinoma has not been determined yet, it should be remembered that anaplastic carcinoma can occur in association with mucinous cystic neoplasm of more benign histology.
  • [MeSH-major] Carcinoma / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Pancreatic Neoplasms / pathology. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 18176976.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 14
  • [Other-IDs] NLM/ PMC2673378
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4. Kuroda N, Iwamura S, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH: Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures. Med Mol Morphol; 2007 Sep;40(3):168-71
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  • [Title] Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures.
  • Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head.
  • The carcinoma components contained adenocarcinoma and squamous cell carcinoma.
  • Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component.
  • Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.
  • [MeSH-major] Carcinoma / pathology. Hyalin / metabolism. Pancreatic Neoplasms / pathology. Rhabdoid Tumor / pathology

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  • [Cites] J Clin Pathol. 2004 Oct;57(10):1106-10 [15452172.001]
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  • (PMID = 17874050.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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5. Nakajima A, Takahashi H, Inamori M, Abe Y, Kobayashi N, Kubota K, Yamanaka S: Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report. J Med Case Rep; 2008;2:391

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  • [Title] Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report.
  • INTRODUCTION: The granulocyte-colony stimulating factor-producing tumor was first reported in 1977, however, anaplastic pleomorphic type carcinoma of the pancreas producing granulocyte-colony stimulating factor is still rare.
  • Based on liver biopsy findings, the tumor was classified as an anaplastic pleomorphic-type carcinoma.
  • Immunohistochemical staining showed that pancreatic carcinoma cells were positive for granulocyte-colony stimulating factor.
  • CONCLUSION: This is a rare case report of anaplastic pleomorphic-type carcinoma of the pancreas producing granulocyte-colony stimulating factor and confirmed by immunohistochemistry.

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  • (PMID = 19091098.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2615780
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6. Sawai H, Okada Y, Funahashi H, Matsuo Y, Takeyama H, Manabe T: Anaplastic carcinoma of the pancreas with squamous features: report of a case and immunohistochemical study. Med Sci Monit; 2005 Nov;11(11):CS65-8
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  • [Title] Anaplastic carcinoma of the pancreas with squamous features: report of a case and immunohistochemical study.
  • BACKGROUND: Anaplastic carcinomas of the pancreas are rare aggressive tumors with survival measurable in weeks.
  • Many terms have been applied used to describe these tumors, and anaplastic foci are identified in ductal adenocarcinomas and in ectopic pancreata, but are not the dominant pattern of growth.
  • We herein present our experience with a case of anaplastic carcinoma of the pancreas with squamous features in order that allowed us to delineate the clinicopathologic and immunohistochemical features of this rare entity.
  • Histopathologically, anaplastic tumor cells showed focal ductal and squamous features infiltrated into pancreatic parenchyma, extrapancreatic fatty tissue, and stomach.
  • CONCLUSIONS: Our immunohistochemical studies suggested that the prognosis of the case with anaplastic carcinoma presented here would be poor, due to the strong expression of integrins and IL-1RI.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Integrins / analysis. Pancreatic Neoplasms / diagnosis. Receptors, Interleukin-1 / analysis
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / diagnosis. Fatal Outcome. Humans. Immunohistochemistry. Male. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Prognosis

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  • (PMID = 16258403.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Integrins; 0 / Receptors, Interleukin-1
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7. Sanada Y, Yoshida K, Itoh M, Okita R, Okada M: Invasive ductal carcinoma of the pancreas showing exophytic growth. Hepatobiliary Pancreat Dis Int; 2009 Feb;8(1):97-102
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  • [Title] Invasive ductal carcinoma of the pancreas showing exophytic growth.
  • BACKGROUND: Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative growth.
  • We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth.
  • An incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the pancreas.
  • RESULTS: The head of the pancreas contained a well-circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50% adenocarcinoma, with mucinous carcinoma in the center and anaplastic carcinoma at the periphery.
  • The anaplastic carcinoma comprised pleomorphic cells (PCs) and pleomorphic giant cells (PGCs).
  • Immunohistochemistry revealed that the anaplastic carcinoma cells including PGCs were positive for the tumor antigen Mucin 1 and CEA but negative for vimentin.
  • CONCLUSION: Our observations suggest anaplastic carcinoma components in the present tumor have a ductal origin and that the exophytic tumor growth is associated with the phagocytotic activity of PGCs.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 19208524.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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8. Okamoto M, Kitajima S, Negishi R, Maehata T, Kouro T, Yamauchi S, Takahashi H, Katakura Y, Watanabe Y, Abiko R, Nakaya S, Inaba H, Takano T, Suzuki M, Itoh F: [Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)]. Nihon Shokakibyo Gakkai Zasshi; 2008 Nov;105(11):1656-65
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  • [Title] [Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)].
  • A huge tumor mass was observed in the tale of the pancreas, which we diagnosed as pancreatic carcinoma.
  • Pathological findings confirmed that it was anaplastic pancreas carcinoma (giant cell type).
  • Irregular tumors with scattered cysts were observed in the tale of the pancreas, which rapidly increased.
  • Autopsy findings confirmed that it was anaplastic pancreas carcinoma (pleomorphic type).
  • Both cases showed positive for epithelial marker and mesenchymal markers and decrease in stainability by E-cadherin staining, a result which suggested diversity of tumor cells in anaplastic pancreas carcinomas.
  • [MeSH-major] Carcinoma / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18987452.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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9. Khashab MA, Emerson RE, DeWitt JM: Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of anaplastic pancreatic carcinoma: a single-center experience. Pancreas; 2010 Jan;39(1):88-91
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of anaplastic pancreatic carcinoma: a single-center experience.
  • OBJECTIVES: Anaplastic carcinoma of the pancreas (ACP) is an aggressive variant of ductal adenocarcinoma.
  • The aim of this study was to describe a single-center experience with the use of endoscopic ultrasound (EUS) with or without fine-needle aspiration (FNA) for the diagnosis of ACP.
  • METHODS: The cytology and surgical pathology databases were searched for a diagnosis of ACP between 1992 and 2008.
  • The diagnosis of ACP was confirmed after surgical resection in 2 of these 5, including one in whom cytology demonstrated only adenocarcinoma.
  • CONCLUSIONS: Anaplastic carcinoma of the pancreas has variable endosonographic features.
  • Endoscopic ultrasound-FNA may assist in the cytological diagnosis of these tumors.
  • [MeSH-major] Carcinoma / pathology. Pancreas / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle / methods. Carcinoma, Pancreatic Ductal / pathology. Diagnosis, Differential. Endosonography. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Survival Analysis

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  • (PMID = 20050229.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Chim CS, Ho J, Ooi GC, Choy C, Liang R: Primary anaplastic large cell lymphoma of the pancreas. Leuk Lymphoma; 2005 Mar;46(3):457-9
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  • [Title] Primary anaplastic large cell lymphoma of the pancreas.
  • We presented a patient with primary ALCL of the pancreas masquerading as a carcinoma of the head of pancreas.
  • She was scheduled for a Whipple's operation and the intra-operative frozen section showed anaplastic carcinoma.
  • The proper diagnosis was only derived later with CD30 immunohistochemical study.
  • This carries important implications on the management, as radical surgery is indicated in resectable carcinoma but not for a chemosensitive lymphoma.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / pathology. Pancreatic Neoplasms / pathology


11. Murata T, Terasaki M, Sakaguchi K, Okubo M, Fukami Y, Nishimae K, Kitayama Y, Hoshi S: A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor. Clin J Gastroenterol; 2009 Apr;2(2):109-114

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  • [Title] A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor.
  • We report a case of anaplastic carcinoma of the pancreas with production of granulocyte-colony stimulating factor (G-CSF) in a 59-year-old male.
  • Differential diagnosis included pancreatic tumors and submucosal tumor of the stomach, but definite preoperative diagnosis could not be made.
  • Histological examination showed anaplastic carcinoma of the pancreas.
  • Therefore, we diagnosed the tumor as anaplastic carcinoma of the pancreas producing G-CSF.

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  • (PMID = 26192175.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Anaplastic carcinoma / Granulocyte-colony stimulating factor / Pancreas
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12. Nishimori H, Takahashi S, Nagasaki E, Kobayashi T, Yokoyama M, Shinozaki E, Mishima Y, Terui Y, Chin K, Mizunuma N, Ito Y, Inamura K, Hatake K: [An autopsied case of metastatic endocrine carcinoma of the pancreas with primary site difficult to identify]. Gan To Kagaku Ryoho; 2005 May;32(5):671-3
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  • [Title] [An autopsied case of metastatic endocrine carcinoma of the pancreas with primary site difficult to identify].
  • A 40-year-old man suffering from right cheek swelling was first diagnosed with ameloblastoma or anaplastic poorly-differentiated carcinoma of the head and neck region.
  • He received 2 courses of CDDP/TXT chemotherapy (cisplatin 75 mg/m2, docetaxel 80 mg/m2) and achieved a partial response, but his carcinoma of the pancreas recurred.
  • The autopsy revealed a pathological diagnosis of metastatic endocrine carcinoma of the pancreas.
  • Poorly-differentiated neuroendocrine carcinomas like this case are highly sensitive to chemotherapy, and a careful pathological diagnosis may clarify its sensitivity to chemotherapy and the prognosis.
  • [MeSH-major] Carcinoma / secondary. Neoplasms, Unknown Primary / pathology. Pancreatic Neoplasms / secondary

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  • (PMID = 15918570.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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13. Turi S, Weickert U, Bohrer MH, Riemann JF: [Space-occupying lesion of the pancreas--how frequently not due to a suspected ductal adenocarcinoma?]. Z Gastroenterol; 2006 Feb;44(2):161-6
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  • [Title] [Space-occupying lesion of the pancreas--how frequently not due to a suspected ductal adenocarcinoma?].
  • In patients with a space-occupying lesion of the pancreas at first a primary ductal adenocarcinoma is considered as the cause.
  • Therapy and prognosis of other pancreas tumours differ from therapy and prognosis of a primary ductal adenocarcinoma.
  • We therefore examined the question of how frequently a space-occupying lesion of the pancreas was not due to a ductal adenocarcinoma in our case materials.
  • Retrospectively 70 patients who had undergone a percutaneous puncture of a space-occupying mass of the pancreas under ultrasonographic control were included in the study (34 women, 36 men).
  • In 62 patients a clear histological diagnosis was possible on the basis of the biopsy.
  • In 53 cases (76 %) a primary adenocarcinoma of the pancreas could be diagnosed.
  • In 5 patients (7 %) these masses turned out to be metastases of a previously known malignant tumour disease (2 x mammary carcinoma, 2 x gastric carcinoma, 1 x sigmoid carcinoma).
  • Other tumours could be detected in 4 cases (6 %) including a tuberculoma, an endocrine tumour, a fusocellular sarcoma with partial neurogenic differentiation and a large-cell and pleomorphic-cell anaplastic, partly sarcomatoid carcinoma.
  • In patients with a space-occupying lesion of the pancreas, tumours other than a ductal adenocarcinoma are not rare.
  • In particular, in cases of a previously known malignant tumour disease a space-occupying lesion of the pancreas can also turn out to be a metastasis.
  • The preoperative biopsy of space-occupying lesions of the pancreas, therefore, still has a clinical importance for the further therapy planning.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / epidemiology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / epidemiology. Pancreatic Neoplasms / pathology

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  • (PMID = 16456757.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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14. Bergmann F, Esposito I, Michalski CW, Herpel E, Friess H, Schirmacher P: Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution. Am J Surg Pathol; 2007 Dec;31(12):1919-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution.
  • Undifferentiated (anaplastic) carcinomas of the pancreas are rare.
  • Thus, as a result from numerous histomorphologic, immunohistochemical, ultrastructural, and molecular examinations, frequently performed as single case studies, it has been concluded that undifferentiated carcinomas and osteoclastlike giant cell tumors of the pancreas originate from epithelial cells, mesenchymal cells, undifferentiated precursor cells, or stem cells.
  • However, to date, early stage tumors have not been described, most likely because of the fact that at the time of diagnosis the tumors have commonly reached advanced stages with large tumor size.
  • In this report, we present the case of an undifferentiated pancreatic carcinoma with osteoclastlike giant cells, which was incidentally detected at a very early stage in a pancreatitis specimen.
  • Therefore, we suggest that the tumor should be considered as an anaplastic variant of pancreatic ductal adenocarcinoma.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / pathology. Giant Cells / pathology. Osteoclasts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18043049.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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15. Angeles-Angeles A, Chable-Montero F, Martinez-Benitez B, Albores-Saavedra J: Unusual metastases of papillary thyroid carcinoma: report of 2 cases. Ann Diagn Pathol; 2009 Jun;13(3):189-96
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  • [Title] Unusual metastases of papillary thyroid carcinoma: report of 2 cases.
  • We present 2 cases of papillary thyroid carcinoma (PTC) with conventional morphology that metastasized to unusual sites.
  • The first neoplasm was a PTC whose initial clinical manifestation was a large metastasis in the pancreas which mimicked a primary neoplasm.
  • Transformation to anaplastic spindle and giant cell carcinoma within the breast metastasis occurred 20 years after the primary thyroid tumor had been diagnosed and surgically treated.
  • The metastatic anaplastic spindle and giant cell carcinoma contained rhabdoid inclusions further complicating identification.
  • To the best of our knowledge, only 3 cases of PTC metastatic to the breast have been reported, none of them with anaplastic transformation.
  • On the other hand, only 3 cases of PTC metastatic to the pancreas have been published, 2 of them of the tall cell variant, and in none of these cases were the first symptoms attributable to the metastasis.
  • Brief comments about the differential diagnosis are included.
  • [MeSH-major] Breast Neoplasms / secondary. Carcinoma, Papillary / secondary. Pancreatic Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 19433299.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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16. Wakatsuki T, Irisawa A, Imamura H, Terashima M, Shibukawa G, Takagi T, Takahashi Y, Sato A, Sato M, Ikeda T, Suzuki R, Hikichi T, Obara K, Ohira H: Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing. Int J Clin Oncol; 2010 Jun;15(3):310-3
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  • [Title] Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing.
  • Histopathologic results revealed anaplastic carcinoma of the pancreas.
  • [MeSH-major] Carcinoma / drug therapy. Drug Screening Assays, Antitumor. Paclitaxel / therapeutic use. Pancreatic Neoplasms / drug therapy. Tubulin Modulators / therapeutic use

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  • [Cites] J Hepatobiliary Pancreat Surg. 1998;5(3):261-8 [9880773.001]
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  • (PMID = 20195681.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Tubulin Modulators; 8L70Q75FXE / Adenosine Triphosphate; P88XT4IS4D / Paclitaxel
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17. Hussain T, Salamat A, Farooq MA, Hassan F, Hafeez M: Indications for endoscopic ultrasound and diagnosis on fine-needle aspiration and cytology. J Coll Physicians Surg Pak; 2009 Apr;19(4):223-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Indications for endoscopic ultrasound and diagnosis on fine-needle aspiration and cytology.
  • OBJECTIVE: To determine common indications for requesting Endoscopic Ultrasound (EUS) and to describe the diagnosis made after endoscopic ultrasound/Fine-Needle Aspiration and Cytology (FNAC) during two years at a tertiary gastrointestinal unit.
  • An on-site cytopathologist made the provisional cytopathological diagnosis.
  • Major indications for referral were lymphadenopathy in 92 (49%), suspected growth pancreas in 57 (28%), growth of stomach in 20 (11%) and a heterogeneous group included esophageal, liver, retroperitoneal masses, rectal and other pathologies.
  • Mass in pancreas was seen in 36, followed by stomach tumour in 17 and esophagus in 9.
  • Final diagnosis out of 67 FNAC/histopathology of lymph nodes were tuberculosis in 26 and malignant lesions in 23.
  • These included metastatic adenocarcinoma in 8, lymphoproliferative disorder in 7, metastatic squamous cell carcinoma in 5, small cell carcinoma in 2 and anaplastic in 1.
  • [MeSH-major] Adenocarcinoma / diagnosis. Endosonography / methods. Lymphatic Diseases / diagnosis. Pancreatic Neoplasms / diagnosis. Stomach Neoplasms / diagnosis. Tuberculosis, Lymph Node / diagnosis
  • [MeSH-minor] Abdomen. Adolescent. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle / methods. Cross-Sectional Studies. Diagnosis, Differential. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Lymphatic Metastasis / ultrasonography. Male. Mediastinum. Middle Aged. Neoplasm Staging. Pancreatitis, Chronic / diagnosis. Pancreatitis, Chronic / pathology. Pancreatitis, Chronic / ultrasonography. Young Adult

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  • (PMID = 19356336.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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18. Peters K, Klöppel G: [Undifferentiated pancreatic carcinomas. Leap into chaos]. Pathologe; 2005 Feb;26(1):18-21
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  • Undifferentiated pancreatic carcinomas are rare anaplastic variants of ductal adenocarcinoma of the pancreas.
  • An uncommon variant is undifferentiated pancreatic carcinoma with osteoclast-like giant cells.
  • [MeSH-minor] Adenocarcinoma / pathology. Carcinoma, Pancreatic Ductal / pathology. Diagnosis, Differential. Humans. Immunohistochemistry

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  • (PMID = 15592673.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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19. Hornick JL, Dal Cin P, Fletcher CD: Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol; 2009 Apr;33(4):542-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We evaluated 350 tumors: 136 ES, including 64 conventional ("distal") ES, 64 proximal-type ES, and 8 with hybrid features of conventional and proximal-type ES; 54 metastatic carcinomas (22 from lung, 6 breast, 6 stomach, 5 colorectum, 5 kidney, 5 prostate, 5 pancreas); 12 metastatic testicular embryonal carcinomas; 20 metastatic melanomas; 20 epithelioid mesotheliomas; 20 epithelioid angiosarcomas; 10 epithelioid hemangioendotheliomas; 24 epithelioid malignant peripheral nerve sheath tumors (MPNST); 22 myoepithelial carcinomas of soft tissue; 7 anaplastic large cell lymphomas; 5 histiocytic sarcomas; and 10 control MRT of infancy (4 brain, 3 liver, 2 soft tissue, 1 kidney).
  • Immunostaining for INI1 can be used to confirm the diagnosis of ES in the appropriate context.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Carcinoma, Embryonal / metabolism. Carcinoma, Embryonal / secondary. Female. Humans. Immunohistochemistry / methods. Infant. Male

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  • (PMID = 19033866.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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20. Al-Brahim N, Ross C, Carter B, Chorneyko K: The value of postmortem examination in cases of metastasis of unknown origin-20-year retrospective data from a tertiary care center. Ann Diagn Pathol; 2005 Apr;9(2):77-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To evaluate the value of autopsy in determining the primary site of MUO, this study reviewed the Hamilton experience-over the last 20 years-with patients autopsied with clinical diagnosis of MUO.
  • Fifty-three cases of MUO were identified (MUO was defined as a patient with pathological and/or radiological diagnosis of a metastatic tumor for which the primary site of malignancy was unknown).
  • Pathological diagnoses at autopsy were adenocarcinoma (n = 37), small cell carcinoma (n = 6), anaplastic carcinoma (n = 3), and undifferentiated carcinoma (n = 3).
  • Primary tumors were identified in 27 patients (51%), most commonly in the lung (n = 8), large bowel (n = 6), and pancreas (n = 4).
  • Histochemical and immunohistochemical stains were helpful in reaching the diagnosis of a primary tumor in 4 of 27 cases.
  • (1) in this series, autopsy was helpful in establishing the diagnosis of a primary tumor in 51% of the cases, reaffirming the value of postmortem examination in these instances;.

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  • (PMID = 15806513.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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21. Nara S: A case of anaplastic carcinoma of the pancreas with portal vein tumor thrombus. Jpn J Clin Oncol; 2010 Jan;40(1):96-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of anaplastic carcinoma of the pancreas with portal vein tumor thrombus.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Portal Vein / radiography. Thrombosis / radiography

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  • (PMID = 20044390.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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22. Salla C, Sakellariou S, Doumani I, Kakiopoulos G, Chatzipantelis P, Karoumpalis I: Neuroendocrine differentiation of anaplastic carcinoma of the pancreas in a case report diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology. Pancreas; 2009 Jan;38(1):103-5
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  • [Title] Neuroendocrine differentiation of anaplastic carcinoma of the pancreas in a case report diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology.
  • [MeSH-major] Biopsy, Fine-Needle. Carcinoma, Neuroendocrine / pathology. Cell Differentiation. Pancreatic Neoplasms / pathology. Ultrasonography, Interventional

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  • (PMID = 19106749.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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23. Benedix F, Schmidt C, Schulz HU, Lippert H, Meyer F, Pech M: Continuous intra-arterial chemotherapy with 5-fluorouracil and cisplatin for locally advanced anaplastic carcinoma of the pancreas. Int J Colorectal Dis; 2008 Jul;23(7):729-31
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  • [Title] Continuous intra-arterial chemotherapy with 5-fluorouracil and cisplatin for locally advanced anaplastic carcinoma of the pancreas.
  • [MeSH-major] Carcinoma / drug therapy. Cisplatin / therapeutic use. Fluorouracil / therapeutic use. Pancreatic Neoplasms / drug therapy

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  • (PMID = 18379798.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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