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1. Hillion J, Wood LJ, Mukherjee M, Bhattacharya R, Di Cello F, Kowalski J, Elbahloul O, Segal J, Poirier J, Rudin CM, Dhara S, Belton A, Joseph B, Zucker S, Resar LM: Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer. Mol Cancer Res; 2009 Nov;7(11):1803-12
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  • [Title] Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer.
  • Although lung cancer is the leading cause of cancer death worldwide, the precise molecular mechanisms that give rise to lung cancer are incompletely understood.
  • Here, we show that HMGA1 is an important oncogene that drives transformation in undifferentiated, large-cell carcinoma.
  • First, we show that the HMGA1 gene is overexpressed in lung cancer cell lines and primary human lung tumors.
  • Forced overexpression of HMGA1 induces a transformed phenotype with anchorage-independent cell growth in cultured lung cells derived from normal tissue.
  • Conversely, inhibiting HMGA1 expression blocks anchorage-independent cell growth in the H1299 metastatic, undifferentiated, large-cell human lung carcinoma cells.
  • We also show that the matrix metalloproteinase-2 (MMP-2) gene is a downstream target upregulated by HMGA1 in large-cell carcinoma cells.
  • In chromatin immunoprecipitation experiments, HMGA1 binds directly to the MMP-2 promoter in vivo in large-cell lung cancer cells, but not in squamous cell carcinoma cells.
  • In large-cell carcinoma cell lines, there is a significant, positive correlation between HMGA1 and MMP-2 mRNA.
  • Moreover, interfering with MMP-2 expression blocks anchorage-independent cell growth in H1299 large-cell carcinoma cells, indicating that the HMGA1-MMP-2 pathway is required for this transformation phenotype in these cells.
  • Blocking MMP-2 expression also inhibits migration and invasion in the H1299 large-cell carcinoma cells.
  • Our findings suggest an important role for MMP-2 in transformation mediated by HMGA1 in large-cell, undifferentiated lung carcinoma and support the development of strategies to target this pathway in selected tumors.

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  • (PMID = 19903768.001).
  • [ISSN] 1557-3125
  • [Journal-full-title] Molecular cancer research : MCR
  • [ISO-abbreviation] Mol. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA092339-01A1; United States / NCI NIH HHS / CA / R01 CA092339; United States / NCI NIH HHS / CA / P50 CA058184; United States / NCI NIH HHS / CA / CA076130-04; United States / NCI NIH HHS / CA / R29 CA076130; United States / NCI NIH HHS / CA / 1R01CA092339; United States / NCI NIH HHS / CA / R29 CA076130-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 124544-67-8 / HMGA1a Protein; EC 3.4.24.24 / Matrix Metalloproteinase 2
  • [Other-IDs] NLM/ NIHMS149386; NLM/ PMC3069640
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2. Otera H, Ikeda F, Nakagawa S, Kono Y, Sakurai T, Tada K, Hashimoto K, Ikeda A: Intussusception of small intestine due to metastasis of large cell carcinoma of the lung with a rhabdoid phenotype. Eur Respir Rev; 2010 Sep;19(117):248-52
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  • [Title] Intussusception of small intestine due to metastasis of large cell carcinoma of the lung with a rhabdoid phenotype.
  • Large cell carcinoma of the lung with a rhabdoid phenotype is a rare type of lung cancer, and does not commonly metastasize to the small intestine.
  • Herein we describe a 63-yr-old Japanese male with ileus resulting from small intestinal metastasis from lung cancer.
  • [MeSH-major] Carcinoma, Large Cell / complications. Carcinoma, Large Cell / secondary. Intussusception / etiology. Intussusception / pathology. Lung Neoplasms / complications. Lung Neoplasms / pathology

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  • (PMID = 20956201.001).
  • [ISSN] 1600-0617
  • [Journal-full-title] European respiratory review : an official journal of the European Respiratory Society
  • [ISO-abbreviation] Eur Respir Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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3. Warenius H, Kyritsi L, Grierson I, Howarth A, Seabra L, Jones M, Thomas C, Browning P, White R: Spontaneous regression of human cancer cells in vitro: potential role of disruption of Cdk1/Cdk4 co-expression. Anticancer Res; 2009 Jun;29(6):1933-41
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  • [Title] Spontaneous regression of human cancer cells in vitro: potential role of disruption of Cdk1/Cdk4 co-expression.
  • BACKGROUND: Although well-acknowledged in vivo, spontaneous death of cancer cells in vitro is less widely appreciated.
  • MATERIALS AND METHODS: Colony formation was studied in untreated control plates of standard clonogenic assays and measurements of actual and potential doubling times performed in asynchronous cultures of human cancer cells lines.
  • Western blotting of lung large cell carcinoma, COR-L23 cells actively undergoing spontaneous cell death was also carried out.
  • RESULTS: Catastrophic disintegration of mature colonies could be seen in the untreated plates of lung large cell carcinoma, H460 and colon adenocarcinoma, SW620 human cancer cell lines and a significant cell loss factor was present in the cell lines growing as adherent cells in continuous culture.
  • Western blotting demonstrated alterations of relative cyclin dependent kinase (Cdk)1 to Cdk4 protein expression in dying COR-L23 cells.
  • CONCLUSION: The phenomenon of spontaneous cell death should be considered a hallmark of cancer and may be the result of failure to stabilise unstable, fully developed cancer cells due to the disruption of Cdk1/Cdk4 co-expression in those cells.
  • [MeSH-major] CDC2 Protein Kinase / metabolism. Carcinoma, Large Cell / pathology. Cyclin-Dependent Kinase 4 / metabolism. Lung Neoplasms / pathology. Neoplasm Regression, Spontaneous / pathology
  • [MeSH-minor] Blotting, Western. Cell Survival. Colony-Forming Units Assay. Fibroblasts / metabolism. Flow Cytometry. Humans. Skin / cytology. Skin / metabolism. Tumor Cells, Cultured

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  • (PMID = 19528450.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 2.7.11.22 / CDC2 Protein Kinase; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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4. Califano L, Sanguedolce F, Staibano S, Pannone G, Tortorella S, Serpico R, Lo Muzio L, Bufo P: Large oral soft tissue metastasis from anaplastic carcinoma of the lung mimicking a primitive malignancy: case report and brief review of the literature. Minerva Stomatol; 2008 Sep;57(9):447-51
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  • [Title] Large oral soft tissue metastasis from anaplastic carcinoma of the lung mimicking a primitive malignancy: case report and brief review of the literature.
  • We describe a case of anaplastic carcinoma of the lung in a 60-year-old man, presenting a huge oral metastasis as the first sign of his primitive lung malignancy.
  • Clinically, the oral lesion mimicked a high-grade primitive carcinoma of the oral cavity.
  • The biopsy established the gingival metastasis from lung cancer which was confirmed by a fine-needle aspiration cytology examination.
  • We report an uncommon case of metastatic lung carcinoma to the gingiva emphasizing the differential diagnosis between primary and metastatic tumours; a short discussion on the pathways of metastatization to oral cavity soft tissues, as well as brief review of the literature are also presented.
  • [MeSH-major] Carcinoma / prevention & control. Lung Neoplasms / pathology. Mouth Neoplasms / secondary. Soft Tissue Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 18923379.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 8
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5. Chen C, Chen P, Zhang CC, Li N, Jin ZL, Li K: [Clinical characteristics and prognosis of large cell lung cancer]. Zhonghua Zhong Liu Za Zhi; 2010 Dec;32(12):932-4
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  • [Title] [Clinical characteristics and prognosis of large cell lung cancer].
  • OBJECTIVE: The aim of this study was to explore the clinical characteristics and analyze the prognostic factors of large cell lung cancer (LCLC).
  • RESULTS: Among the 111 cases, the lesions were in the right lung of 53 patients and 26 of them were located in the superior lobe.
  • The lesions were in the left lung of 58 cases, and 35 of them were in the superior lobe.
  • CONCLUSION: The prognosis of LCLC is worse than other types of non-small cell lung cancer.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / surgery. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Pneumonectomy / methods

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  • (PMID = 21223803.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Taxoids; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; CAP-1 protocol; TP protocol
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6. Ceppi P, Volante M, Ferrero A, Righi L, Rapa I, Rosas R, Berruti A, Dogliotti L, Scagliotti GV, Papotti M: Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors. Clin Cancer Res; 2008 Feb 15;14(4):1059-64
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  • EXPERIMENTAL DESIGN: A series of 116 NETs were collected, including 58 gastroenteropancreatic (GEP) and 58 lung NETs.
  • RESULTS: By means of both quantification by real-time PCR and immunohistochemistry, a higher TS expression in pulmonary small cell lung cancer and large cell NEC compared with typical and atypical carcinoids was observed (P < 0.01).
  • [MeSH-major] Digestive System Neoplasms / enzymology. Drug Resistance, Neoplasm / physiology. Lung Neoplasms / enzymology. Neuroendocrine Tumors / enzymology. Thymidylate Synthase / biosynthesis

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  • (PMID = 18281538.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / RNA, Messenger; EC 2.1.1.45 / Thymidylate Synthase; U3P01618RT / Fluorouracil
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7. Ye L, Li X, Kong X, Wang W, Bi Y, Hu L, Cui B, Li X, Ning G: Hypomethylation in the promoter region of POMC gene correlates with ectopic overexpression in thymic carcinoids. J Endocrinol; 2005 May;185(2):337-43
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  • Using bisulphite sequencing, we identified hypermethylation in the 5' promoter region of the POMC gene in three normal thymuses and one large cell lung cancer, and hypomethylation in five thymic carcinoid tumors resected from patients with ectopic ACTH syndrome.

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  • (PMID = 15845926.001).
  • [ISSN] 0022-0795
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; 66796-54-1 / Pro-Opiomelanocortin
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8. Majima T, Komatsu Y, Doi K, Shigemoto M, Takagi C, Fukao A, Kojima M, Tamaki H, Ito J, Nakao K: Anaplastic thyroid carcinoma associated with Graves' disease. Endocr J; 2005 Oct;52(5):551-7
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  • [Title] Anaplastic thyroid carcinoma associated with Graves' disease.
  • This report concerns a 79-year-old woman with coexisting anaplastic thyroid carcinoma (ATC) and Graves' disease (GD).
  • These findings led to a diagnosis of GD.
  • On the other hand, the thyroid nodule could not be definitely diagnosed even after fine needle aspiration biopsy (FNAB) which produced findings suggestive of both papillary thyroid carcinoma and ATC.
  • Regional lymph node metastases as well as multiple lung metastases, which could not be found at the initial visit, had been already developed by that time.
  • Our case is pathophysiologically interesting because it suggests that GD or thyroid-stimulating antibodies (TSAb) may stimulate malignant transformation of differentiated carcinoma.
  • [MeSH-major] Carcinoma / complications. Graves Disease / complications. Thyroid Neoplasms / complications

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  • (PMID = 16284432.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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9. Kudo K, Sakamoto S, Miyamoto A, Kono T, Motoi N, Yoshimura K: [A case of large cell carcinoma of the lung associated with a sarcoid-like reaction inside the tumor]. Nihon Kokyuki Gakkai Zasshi; 2008 Nov;46(11):889-93
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  • [Title] [A case of large cell carcinoma of the lung associated with a sarcoid-like reaction inside the tumor].
  • An 83 year-old man who was found to have a mass in his left lower lung field on a chest radiograph.
  • The patient was referred to our hospital, and lung biopsy under video-assisted thoracoscopic surgery (VATS) was performed.
  • Since the initial intraoperative pathologic examination showed the presence of non-caseating epithelioid cell granulomas, only partial resection was conducted.
  • However, detailed postoperative histopathological evaluation led to a diagnosis of large cell carcinoma of the lung associated with an internal sarcoid-like reaction.
  • Formation of epithelioid cell granulomas within a tumor is quite rare.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Lung Neoplasms / pathology

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  • (PMID = 19068761.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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10. De P, Abbasi R, Senadhira T, Orr P, Ullah A: Urticaria and large cell undifferentiated carcinoma of lung. Dermatol Online J; 2005;11(3):45
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  • [Title] Urticaria and large cell undifferentiated carcinoma of lung.
  • The association of urticaria with internal cancer is known mostly with lymphoreticular system malignancies.
  • Rarely, it occurs with cancer of lung, mostly with adenocarcinoma or small cell carcinoma.
  • We report a unique occurrence of urticaria on a patient who suffered from large cell undifferentiated carcinoma of lung.
  • [MeSH-major] Carcinoma, Large Cell / complications. Lung Neoplasms / complications. Urticaria / etiology

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  • (PMID = 16409941.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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11. Tanaka T, Sekimura A, Tanaka H, Tonegawa K, Ogawa K, Haneda H: [Gallbladder metastasis of large cell lung cancer]. Kyobu Geka; 2009 Nov;62(12):1069-72
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  • [Title] [Gallbladder metastasis of large cell lung cancer].
  • A man, who received right upper lobectomy of the lung due to stage IIB large cell carcinoma 7 and half years ago, visited our hospital complaining of right upper abdominal pain.
  • Pathological diagnosis was adenosquamous cell carcinoma After 1 year and 4 months later, left adrenal gland tumor was found by CT scan, and the surgery was conducted.
  • Pathologically, it was diagnosed as metastasis from lung cancer.
  • By reevaluation of pathology of the gallbladder, the tumor was found to have similar component of resected lung cancer, suggesting the possibility of the tumor to be metastatic.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Gallbladder Neoplasms / secondary. Lung Neoplasms / pathology

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  • (PMID = 19894573.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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12. Goto H, Ito M, Yamaguchi N, Takahashi K, Kawano N, Kaneko T, Ishigatsubo Y: [A case of large cell carcinoma of the lung with rhabdoid phenotype]. Nihon Kokyuki Gakkai Zasshi; 2006 Apr;44(4):325-9
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  • [Title] [A case of large cell carcinoma of the lung with rhabdoid phenotype].
  • A 37-year-old man was admitted to our hospital because of suspicion of the lung cancer in November 2003.
  • Transbronchial tumor biopsy revealed a small number of tumor cells with rhabdoid features, which had eosinophilic cytoplasmic globules.
  • However, a definitive histological diagnosis was not obtained.
  • We considered that a diagnosis of lung malignant tumor was likely according to the findings of chest CT scan and pathology.
  • Immunohistologic staining of the cervical lymph node showed that rhabdoid cells were positive for epithelial membrane antigen (EMA), vimentin, and anticytokeratin antibody (CAM5.2), but not for thyroid transcription factor-1 (TTF-1).
  • From the autopsy findings and clinical course, he was finally diagnosed with large cell carcinoma of the lung with rhabdoid phenotype.
  • Because of its aggressive clinical course, early diagnosis and decision on therapy would be very important for this disease.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Rhabdoid Tumor / pathology
  • [MeSH-minor] Adult. Duodenal Neoplasms / secondary. Humans. Lung / pathology. Lung / radiography. Male. Phenotype. Tomography, X-Ray Computed

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  • (PMID = 16681249.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Tokat AO, Yüksel C, Ozdemir Kumbasar O, Güngör A: [Association of combined small cell and large cell lung cancer with Lambert-Eaton myasthenic syndrome: case report]. Tuberk Toraks; 2005;53(2):177-80
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  • [Title] [Association of combined small cell and large cell lung cancer with Lambert-Eaton myasthenic syndrome: case report].
  • Lambert-Eaton myasthenic syndrome (LEMS) is a rare type of neuromusculer conduction disorder.
  • This disease can be seen with lung cancer and, it is associated with otoimmunity.
  • Among the symptoms of lung cancer LEMS can be seen, but it is very rare.
  • In this case, LEMS symptoms were analyzed before lung cancer symptoms.
  • [MeSH-major] Lambert-Eaton Myasthenic Syndrome / diagnosis
  • [MeSH-minor] Aged. Carcinoma, Large Cell / complications. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / pathology. Carcinoma, Large Cell / radiography. Carcinoma, Small Cell / complications. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / radiography. Diagnosis, Differential. Humans. Lung Neoplasms / complications. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology. Lung Neoplasms / radiography. Male. Neoplasms, Multiple Primary / complications. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / radiography

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  • (PMID = 16100656.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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14. Schmid I, Fliegner M: [Digital ischemia of a patient with undifferentiated large cell lung cancer]. Internist (Berl); 2008 Mar;49(3):346-8
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  • [Title] [Digital ischemia of a patient with undifferentiated large cell lung cancer].
  • [Transliterated title] Digitale Ischämien bei einer Patientin mit grosszelligem Lungenkarzinom.
  • We report about a woman with a metastatic lung cancer, who was admitted because of pain in her left hand with necrosis of the fingertips and of the fifth right toe.
  • [MeSH-major] Carcinoma, Large Cell / complications. Carcinoma, Large Cell / diagnosis. Lung Neoplasms / diagnosis. Paraneoplastic Syndromes / diagnosis. Raynaud Disease / diagnosis. Raynaud Disease / etiology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Cites] Radiologe. 1996 Sep;36(9):692-9 [8999444.001]
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  • (PMID = 18214409.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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15. Takahashi S, Kosaka T, Hattori M, Fujimoto-Ouchi K, Shimonaka Y, Yasuno H, Noguchi M, Mori K, Ogata E: Cancer-related anemia: Correlation analysis among serum levels of hemoglobin, IL-6, hepcidin, albumin, and erythropoietin. J Clin Oncol; 2009 May 20;27(15_suppl):e20655

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cancer-related anemia: Correlation analysis among serum levels of hemoglobin, IL-6, hepcidin, albumin, and erythropoietin.
  • In the present study, we investigated the relationship between cancer-related anemia and inflammatory activity, including the cytokines.
  • The characteristics of anemia in cancer pts were compared with those in mice bearing human lung large cell cancer LC-6-JCK.
  • Correlations were observed between quality of life in cancer pts and anemia parameters including Hb and IL-6.
  • Mice bearing LC-6-JCK tumors developed anemia with characteristic parameters similar to cancer pts with anemia ( Table ).
  • CONCLUSIONS: Present results suggest that cancer-related anemia associates with IL-6, Alb and inflammatory acute phase reaction including hepcidin and ferritin.
  • Further analysis of anemia in cancer pts and murine models would be useful for investigating the mechanisms of cancer anemia.

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  • (PMID = 27961624.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Ricciardelli L, Rapicano G, Pinto A, Napolitano G, Feleppa C, Martino G, Martino A: [Small bowel intussusception caused by metastasis from anaplastic thyroid carcinoma: case report and literature review]. Ann Ital Chir; 2006 Jan-Feb;77(1):63-7
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  • [Title] [Small bowel intussusception caused by metastasis from anaplastic thyroid carcinoma: case report and literature review].
  • [Transliterated title] Invaginazione ileo-ileale da metastasi di carcinoma anaplastico tiroideo. Caso clinico e revisione della letteratura.
  • Symptomatic involvement of the small bowel by metastasis from an extra-abdominal primary malignancy is rare, most commonly resulting from malignant melanoma and lung cancer; very rarely is small bowel involvement as first metastatic site.
  • The Authors report a case of anaplastic thyroid carcinoma with lung metastasis, brain metastasis and an isolated metastasis to the small bowel leading intestinal obstruction due to small bowel intussusception.
  • The Authors review the international literature about frequency, etiopathogenesis, clinical and diagnostic features and therapy of small bowel metastasis by extra-abdominal malignancies, especially by primary anaplastic thyroid carcinoma.
  • Small bowel metastasis from extra-abdominal malignancies are very unusual, especially from anaplastic thyroid carcinoma, and the etiopathogenesis is still unknown.
  • Clinical findings are typical for abdominal urgency, especially by small bowel obstruction from anaplastic thyroid carcinoma.
  • [MeSH-major] Carcinoma / complications. Carcinoma / diagnosis. Ileal Neoplasms / complications. Ileal Neoplasms / diagnosis. Intussusception / etiology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Brain Neoplasms / secondary. Female. Humans. Ileal Diseases / etiology. Lung Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 16910363.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 37
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17. Rekhtman N: Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med; 2010 Nov;134(11):1628-38
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  • [Title] Neuroendocrine tumors of the lung: an update.
  • CONTEXT: The 2004 World Health Organization (WHO) classification recognizes 4 major types of lung neuroendocrine tumors: typical carcinoid, atypical carcinoid, small cell lung cancer, and large cell neuroendocrine carcinoma.
  • Markedly different prognostic implications and treatment paradigms for these tumors underscore the importance of accurate pathologic diagnosis.
  • OBJECTIVE: To detail the clinical and pathologic features of lung neuroendocrine tumors, with emphasis on diagnostic criteria, differential diagnoses, and application of immunohistochemistry.
  • The emerging evidence for the utility of Ki-67 (MIB1) in the diagnosis of lung neuroendocrine tumors, particularly in small biopsy and cytology, is emphasized.
  • Ki-67 (MIB1) is emerging as a useful ancillary tool in the diagnosis of these tumors.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor. Diagnosis, Differential. Humans. Immunohistochemistry. Prognosis

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  • (PMID = 21043816.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Pratz KW, Ma C, Aubry MC, Vrtiska TJ, Erlichman C: Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison syndrome. Mayo Clin Proc; 2005 Jan;80(1):116-20
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  • [Title] Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison syndrome.
  • Verner-Morrison syndrome, characterized by diarrhea, hypokalemia, and hypochlorhydria, is caused most commonly by vasoactive intestinal polypeptide-secreting islet cell tumors of the pancreas.
  • Verner-Morrison syndrome has not been described as a paraneoplastic syndrome in non-small cell lung cancer.
  • We describe a 38-year-old man with metastatic non-small cell lung cancer of large cell carcinoma with neuroendocrine differentiation who presented with bone metastasis and intractable secretory diarrhea that was unresponsive to pharmacological treatment, including octreotide.
  • To our knowledge, this is the first published case of large cell carcinoma with neuroendocrine differentiation associated with treatment-responsive paraneoplastic Verner-Morrison syndrome.
  • [MeSH-major] Calcitonin / secretion. Carcinoma, Large Cell / secretion. Lung Neoplasms / secretion. Pancreatic Neoplasms / etiology. Paraneoplastic Endocrine Syndromes / etiology. Vasoactive Intestinal Peptide / metabolism. Vipoma / etiology

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  • (PMID = 15667039.001).
  • [ISSN] 0025-6196
  • [Journal-full-title] Mayo Clinic proceedings
  • [ISO-abbreviation] Mayo Clin. Proc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 37221-79-7 / Vasoactive Intestinal Peptide; 9007-12-9 / Calcitonin; RWM8CCW8GP / Octreotide
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19. Sampson JB, Smith SM, Smith AG, Singleton JR, Chin S, Pestronk A, Flanigan KM: Paraneoplastic myopathy: response to intravenous immunoglobulin. Neuromuscul Disord; 2007 May;17(5):404-8
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  • A third case represents the first association of anti-signal recognition particle (anti-SRP) syndrome with large-cell lung cancer.
  • These cases highlight the role of histopathologic diagnosis in directing the treatment of paraneoplastic myopathy, and the role for IVIG in treatment of the syndrome.

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  • (PMID = 17336069.001).
  • [ISSN] 0960-8966
  • [Journal-full-title] Neuromuscular disorders : NMD
  • [ISO-abbreviation] Neuromuscul. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Complement Membrane Attack Complex; 0 / Immunoglobulins, Intravenous
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20. Uzaslan E, Ebsen M, Stuempel T, Freudenberg N, Nakamura S, Costabel U, Guzman J: Surfactant protein A detection in large cell carcinoma of the lung. Appl Immunohistochem Mol Morphol; 2006 Mar;14(1):88-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surfactant protein A detection in large cell carcinoma of the lung.
  • Large cell carcinomas of the lung are undifferentiated malignant epithelial tumors that lack cytologic features of small cell carcinoma, glandular cell carcinoma, or squamous cell differentiation.
  • Lung surfactant protein A (SP-A) is produced by alveolar type II cells and Clara cells.
  • Most bronchioloalveolar carcinomas of the lung react positively for SP-A.
  • Positive SP-A staining of large cell carcinoma of the lung could indicate that at least part of these tumors have the same cellular origin or differentiation as bronchioloalveolar carcinoma.
  • The authors determined the SP-A staining of 63 large cell carcinomas of the lung by IHC.
  • This may imply that about one third of large cell carcinomas of the lung have a similar cellular origin or differentiation as bronchioloalveolar carcinoma.

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  • (PMID = 16540737.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pulmonary Surfactant-Associated Protein A
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21. Zhong D, Guo L, de Aguirre I, Liu X, Lamb N, Sun SY, Gal AA, Vertino PM, Zhou W: LKB1 mutation in large cell carcinoma of the lung. Lung Cancer; 2006 Sep;53(3):285-94
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  • [Title] LKB1 mutation in large cell carcinoma of the lung.
  • Germline inactivation of LKB1 is responsible for Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by benign hamartomas of the GI tract and an increased predisposition to certain cancers, including lung.
  • Acquired mutations in LKB1 are rarely observed in most sporadic tumor types except for adenocarcinomas of the lung where up to 50% harbor inactivating mutations.
  • In this study, we focused on LKB1 mutations in lung cancer cell lines originating from large cell carcinomas.
  • We identified a novel 1.5kb interstitial deletion within LKB1 gene in H157 cancer cells.
  • The truncated transcript was expressed at relatively low levels, and the truncated LKB1 protein was virtually undetectable in this cell line.
  • Phosphorylation of AMPK-alpha was attenuated in H157 cells treated with 2-deoxyglucose, and could be rescued by expression of an exogenous GFP-LKB1 fusion protein.
  • Of the four cell lines and six primary tumors of large cell lung carcinoma origin that have been evaluated in this and other studies, LKB1 mutations have been found in three cases.
  • These results suggest that, in addition to adenocarcinomas, acquired loss of function mutations in LKB1 may also be frequently involved in the pathogenesis of large cell lung carcinomas.
  • [MeSH-major] Carcinoma, Large Cell / metabolism. Gene Expression Regulation, Neoplastic. Lung Neoplasms / genetics. Protein-Serine-Threonine Kinases / genetics. Protein-Serine-Threonine Kinases / physiology
  • [MeSH-minor] AMP-Activated Protein Kinases. Alleles. Cell Line, Tumor. DNA, Complementary / metabolism. Gene Deletion. Green Fluorescent Proteins / metabolism. Homozygote. Humans. Loss of Heterozygosity. Multienzyme Complexes / metabolism. Mutation. Phosphorylation. Protein Structure, Tertiary

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  • (PMID = 16822578.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA077337
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Multienzyme Complexes; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / AMP-Activated Protein Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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22. Mehta H, Bahuva R, Sadikot RT: Lung cancer mimicking as pregnancy with pneumonia. Lung Cancer; 2008 Sep;61(3):416-9
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  • [Title] Lung cancer mimicking as pregnancy with pneumonia.
  • SUMMARY: Lung cancer that presents with secretion of beta HCG is rare.
  • With non-resolution of the consolidation and progression of her symptoms she subsequently was found to have large cell lung cancer with ectopic beta HCG secretion.
  • Ectopic production of a variety of hormones such as ADH, parathyroid hormone, ACTH, insulin-like growth factor thus leading to presentation as endocrine syndromes in patients with lung cancer is well known.
  • The presentation of lung cancer mimicking as pregnancy has not been previously reported.
  • This may prevent a delay in the diagnosis and treatment of malignancy in young women.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / metabolism. Chorionic Gonadotropin, beta Subunit, Human / metabolism. Lung Neoplasms / diagnosis. Lung Neoplasms / metabolism
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Humans. Pneumonia / diagnosis. Pregnancy. Tomography, X-Ray Computed

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  • (PMID = 18304689.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
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23. Martin AC, Friedlander M, Kiernan MC: Paraneoplastic mononeuritis multiplex in non-small-cell lung carcinoma. J Clin Neurosci; 2006 Jun;13(5):595-8
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  • [Title] Paraneoplastic mononeuritis multiplex in non-small-cell lung carcinoma.
  • A 60-year-old man developed two selective peripheral mononeuropathies of the peroneal and later the radial nerve, shortly after a diagnosis of large-cell lung carcinoma.
  • Subsequent magnetic resonance imaging of the lower limb excluded focal compression or malignant infiltration along the course of the peroneal nerve, and there was no signal change within the nerve, prompting a diagnosis of paraneoplastic mononeuritis multiplex.
  • Neither the patient's large-cell lung carcinoma nor mononeuritis multiplex responded to chemotherapy, and he died within 6 months of the initial diagnosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / radiography. Paraneoplastic Polyneuropathy / radiography. Peroneal Neuropathies / radiography. Radial Neuropathy / radiography

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  • (PMID = 16564174.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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24. Singh N, Srinivas R, Bal A, Aggarwal AN: Lung carcinoma mimicking hydatid cyst: a case report and review of the literature. Med Oncol; 2009 Dec;26(4):424-8
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  • [Title] Lung carcinoma mimicking hydatid cyst: a case report and review of the literature.
  • It is unusual for a malignant lung tumor to present clinically as a cystic lesion.
  • A case of large cell carcinoma of the lung mimicking pulmonary hydatid cyst is reported herein.
  • The patient was found to have positive serological test for Echinococcus granulosus and therefore the preoperative diagnosis was that of complicated pulmonary hydatid cyst.
  • Intra-operative findings included presence of a large cavity filled with necrotic material and "daughter cysts".
  • Histopathological evaluation of the excised specimen showed large cell carcinoma.
  • The case highlights the fact that a lung carcinoma may rarely have clinical, radiological, and serological features similar to those of a pulmonary hydatid cyst.
  • [MeSH-major] Carcinoma, Large Cell / diagnosis. Echinococcosis, Pulmonary / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Aged. Animals. Diagnosis, Differential. Echinococcosis / diagnostic imaging. Echinococcosis / pathology. Echinococcosis / surgery. Echinococcus granulosus. Humans. Male. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 19067256.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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25. Naranjo Gómez JM, Gómez Román JJ: Behaviour and survival of high-grade neuroendocrine carcinomas of the lung. Respir Med; 2010 Dec;104(12):1929-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Behaviour and survival of high-grade neuroendocrine carcinomas of the lung.
  • INTRODUCTION: Large-cell neuroendocrine carcinoma is an aggressive variant of large-cell carcinoma of the lung, which has poor survival in most series, resembling that of small-cell lung carcinoma.
  • METHODS: 33 large-cell neuroendocrine carcinomas and 16 peripheral small-cell lung carcinomas were reassessed retrospectively.
  • RESULTS: In large-cell neuroendocrine carcinomas, there were 25 patients with pathologic stage I, 4 with pathologic stage II and 4 with pathologic stage III.
  • In small-cell lung carcinomas, there were 6 patients with pathologic stage I, 3 with pathologic stage II and 7 with pathologic stage III.
  • 12% of large-cell neuroendocrine carcinomas and 62.5% of small-cell lung carcinomas were of advanced disease.
  • CONCLUSION: Large-cell neuroendocrine carcinomas of the lung have poor prognosis even in early stages, with survival rates similar to that of small-cell lung carcinomas.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Lung Neoplasms / pathology

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20810262.001).
  • [ISSN] 1532-3064
  • [Journal-full-title] Respiratory medicine
  • [ISO-abbreviation] Respir Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Paripati A, Kingsley C, Weiss GJ: Pathway targets to explore in the treatment of small cell and large cell lung cancers. J Thorac Oncol; 2009 Nov;4(11):1313-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathway targets to explore in the treatment of small cell and large cell lung cancers.
  • INTRODUCTION: With low 5-year survival rates and little progress in therapy, improvements in therapeutic strategies for the treatment of small cell lung cancer (SCLC) and large cell lung cancer (LCC) are warranted.
  • The remaining pathways are targeted by several drugs developed or under development in cancer therapeutics.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Large Cell / genetics. Carcinoma, Non-Small-Cell Lung / genetics. Gene Expression Regulation, Neoplastic. Genes, Neoplasm / genetics. Lung Neoplasms / genetics. Signal Transduction / genetics

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  • (PMID = 19812504.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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27. Ito Y, Higashiyama T, Hirokawa M, Fukushima M, Inoue H, Yabuta T, Tomoda C, Uruno T, Kihara M, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Miyauchi A: Prognosis of patients with papillary carcinoma showing anaplastic transformation in regional lymph nodes that were curatively resected. Endocr J; 2008 Dec;55(6):985-9
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  • [Title] Prognosis of patients with papillary carcinoma showing anaplastic transformation in regional lymph nodes that were curatively resected.
  • Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis.
  • Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes.
  • We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected.
  • Two of these patients showed anaplastic transformation at the initial surgery and the remaining 3 showed anaplastic transformation after repeated recurrence to the lymph nodes.
  • After resection of anaplastic lesions of the nodes, 2 patients underwent radiation therapy, whereas the remaining 3 did not receive any adjuvant therapy.
  • One patient died of rapid growth of lung metastasis 5 months after the resection.
  • One patient died of carcinoma 63 months after surgery.
  • It is therefore suggested that long-term survival can be expected for patients with differentiated carcinoma showing anaplastic transformation in the lymph node if the lesions can be curatively resected.
  • [MeSH-major] Carcinoma / secondary. Carcinoma, Papillary / diagnosis. Lymph Nodes / surgery. Thyroid Neoplasms / diagnosis

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  • (PMID = 18612180.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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28. Oktay MH, Smolkin MB, Williams M, Cajigas A: Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma: report of a case of a challenging cytologic diagnosis. Acta Cytol; 2006 Mar-Apr;50(2):201-4
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  • [Title] Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma: report of a case of a challenging cytologic diagnosis.
  • BACKGROUND: The probability of anaplastic transformation in a differentiated thyroid carcinoma (DTC) is <2%.
  • Admixture of DTC and undifferentiated carcinoma can occasionally be found in thyroidectomy specimens, or the undifferentiated tumor may develop in metastatic foci months or years after removal of the primary tumor.
  • CASE: Anaplastic transformation of a metastatic DTC was diagnosed at autopsy in a 71-year-old female.
  • At the time of her total thyroidectomy for follicular carcinoma, she already had several lung nodules, which diminished in size upon 131I treatment.
  • Five years later the patient developed a new, pleura-based lung mass.
  • Fine needle aspiration biopsy of the paraspinal mass resulted in a diagnosis of metastatic squamous cell carcinoma.
  • Histologic evaluation of the lung nodules and pleura-based mass revealed areas of follicular carcinoma intermixed with a various patterns of undifferentiated carcinoma.
  • The paraspinal and kidney mass consisted entirely of anaplastic tumor, including areas of squamoid differentiation.
  • CONCLUSION: In patients with a history of DTC who develop a rapidly growing mass elsewhere, a possibility of metastatic DTC with anaplastic transformation must be considered.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Kidney Neoplasms / secondary. Lung Neoplasms / secondary. Spinal Neoplasms / secondary. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Disease Progression. Fatal Outcome. Female. Humans. Sensitivity and Specificity


29. Cutz JC, Guan J, Bayani J, Yoshimoto M, Xue H, Sutcliffe M, English J, Flint J, LeRiche J, Yee J, Squire JA, Gout PW, Lam S, Wang YZ: Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changes. Clin Cancer Res; 2006 Jul 1;12(13):4043-54
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  • [Title] Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changes.
  • PURPOSE: Lung cancer is a biologically diverse disease and relevant models reflecting its diversity would facilitate the improvement of existing therapies.
  • With a view to establishing such models, we developed and evaluated xenografts of a variety of human lung cancers.
  • EXPERIMENTAL DESIGN: Using nonobese diabetic/severe combined immunodeficiency mice, subrenal capsule xenografts were generated from primary lung cancer tissue, including moderately and poorly differentiated squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, small cell carcinoma, large cell undifferentiated carcinoma, and carcinosarcoma.
  • Immunohistochemistry and fluorescence in situ hybridization confirmed the human origin of the tumor cells and development in xenografts of murine supportive stroma.
  • Four transplantable lines were developed from rapidly growing tumors (>5 generations), i.e., a small cell lung carcinoma, large cell undifferentiated carcinoma, pulmonary carcinosarcoma, and squamous cell carcinoma.
  • Analyses including spectral karyotyping, comparative genomic hybridization, and fluorescence in situ hybridization, revealed that the xenografts were genetically similar to the original tumors, showing chromosomal abnormalities consistent with karyotypic changes reported for lung cancer.
  • CONCLUSIONS: The subrenal capsule xenograft approach essentially provides a living tumor bank derived from patient material and a means for isolating and expanding specific cell populations.
  • [MeSH-major] Cell Line, Tumor. Disease Models, Animal. Lung Neoplasms / pathology. Subrenal Capsule Assay


30. Kohli PS, Soni NK: Nasal tip metastasis: an unusual site and mode of spread in anaplastic thyroid carcinoma. Indian J Otolaryngol Head Neck Surg; 2008 Sep;60(3):269-70

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  • [Title] Nasal tip metastasis: an unusual site and mode of spread in anaplastic thyroid carcinoma.
  • Anaplastic thyroid carcinoma (ATC) is the most aggressive and lethal form of thyroid malignancy which is difficult to treat.
  • At the time of diagnosis, majority of patients have distant metastases most commonly in lung, bone, and liver.
  • Implantation of malignant cells on nasal tip is also unknown.

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  • [Cites] J Am Acad Dermatol. 1990 Jan;22(1):19-26 [2298962.001]
  • [Cites] Surg Gynecol Obstet. 1971 Oct;133(4):673-7 [4938079.001]
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  • (PMID = 23120560.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450640
  • [Keywords] NOTNLM ; Implantation metastasis / Nasal metastasis / Thyroid carcinoma
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31. Pan Y, Li WX, Li JM, Zhu JQ, Liang YQ, Guo AL: [Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines]. Ai Zheng; 2009 Jul;28(7):714-7
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  • [Title] [Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines].
  • BACKGROUND AND OBJECTIVE: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays an important role in repairing irradiation-induced DNA double-strand break (DSB), and affects the radiosensitivity of tissue cells.
  • This study was to detect the expression of DNA-PKcs in different non-small cell lung cancer (NSCLC) cell lines and evaluate its correlation to radiosensitivity.
  • METHODS: The content and activity of DNA-PKcs in five NSCLC cell lines A549, H1299, L78, PGCL3 and H460 were measured by Western blot and the DNA-PK activity assay.
  • Cell survival was analyzed using clonogenic formation assay.
  • RESULTS: The radiosensitivities of five NSCLC cell lines were different.
  • The values of survival fraction at 2 Gy (SF2) were 0.74 in A549 cells, 0.25 in H1299 cells, 0.21 in H460 cells, 0.48 in PGCL3 cells, and 0.58 in L78 cells.
  • The protein levels of DNA-PKcs were 3.26+/-0.98 in A549 cells, 0.51+/-0.07 in L78 cells, 0.51+/-0.11 in H1299 cells, 0.86+/-0.23 in H460 cells, and 2.60+/-0.76 in PGCL3 cells.
  • The activity values of DNA-PKcs were 8.30+/-1.03 in A549 cells, 2.45+/-0.52 in H1299 cells, 0.11+/-0.02 in H460 cells, 4.13+/-0.87 in PGCL3 cells, and 0.42+/-0.07 in L78 cells.
  • In adenocarcinoma and large cell carcinoma cell lines, SF2 were correlated to DNA-PKcs content (P<0.05, r=0.95) and activity (P=0.03, r=0.98).
  • CONCLUSION: DNA-PKcs is an important factor to predict the radiosensitivity in adenocarcinoma and large cell lung cancer cell lines.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Cell Survival / radiation effects. DNA-Activated Protein Kinase / metabolism. Lung Neoplasms / pathology. Radiation Tolerance
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Carcinoma, Large Cell / metabolism. Carcinoma, Large Cell / pathology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Catalytic Domain. Cell Line, Tumor. Enzyme Activation / radiation effects. Humans. Particle Accelerators

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  • (PMID = 19624897.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.11.1 / DNA-Activated Protein Kinase
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32. Zou LJ, Li GQ, Gong LL, Wang Y, Jin W, Zhao JY, Ma HY, Yang PM, Shao SJ: [Expression of aurora-A kinase in human lung cancer cell lines PG, A549, and NCI-H460]. Ai Zheng; 2005 Jul;24(7):792-5
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  • [Title] [Expression of aurora-A kinase in human lung cancer cell lines PG, A549, and NCI-H460].
  • This study was to detect the expression of Aurora-A in lung cancer cell lines PG (highly-metastatic giant cell lung cancer), A549 (lung adenocarcinoma), and NCI-H460 (large cell lung cancer) and explore its correlation to DNA content, provide a theoretical basis for screening tumor marker and molecular therapeutic target of lung cancer.
  • METHODS: mRNA and protein levels of Aurora-A in PG, A549, and NCI-H460 cells were detected by reverse transcription-polymerase chain reaction(RT-PCR) and Western blot.
  • Flow cytometry was used to analyze DNA contents in cell cycles of PG, A549, and NCI-H460 cells.
  • RESULTS: mRNA level of Aurora-A was 1.14 in PG cells, 1.16 in A549 cells, and 0.84 in NCI-H460 cells, respectively; protein level of Aurora-A was 8.96 in PG cells, 21.13 in A549 cells, and 6.43 in NCI-H460 cells, respectively.
  • The proportion of cells with tetraploid DNA was 19.88% in PG cells, 14.97% in A549 cells, and 10.6% in NCI-H460 cells, respectively (P<0.01); the proportion of cells with polyploid DNA was 2.66% in PG cells, 3.59% in A549 cells, and 2.30% in NCI-H460 cells, respectively.
  • CONCLUSION: Aurora-A is overexpressed in the 3 lung cancer cell lines, but the mRNA levels are different.
  • [MeSH-major] Adenocarcinoma / metabolism. Carcinoma, Giant Cell / metabolism. Carcinoma, Large Cell / metabolism. Lung Neoplasms / metabolism. Protein-Serine-Threonine Kinases / biosynthesis
  • [MeSH-minor] Aurora Kinases. Cell Line, Tumor. DNA, Neoplasm / genetics. Humans. Polyploidy. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16004802.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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33. Zhou ZY, Sun RC, Yang GY, Yang SD, Yu MH, Liang JB: Giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity: a distinctive form of thymic carcinoma? Int J Surg Pathol; 2010 Oct;18(5):363-8
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  • [Title] Giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity: a distinctive form of thymic carcinoma?
  • Here, the authors describe a case of giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity-which could be a distinctive form of thymic carcinoma-which expressed CD5 and CD45.
  • During the operation, it was found that the mass occupied most of the chest invading the chest wall, aorta, vena cava, and lung tissue.
  • The tumor was composed of large areas of necrosis and anaplastic neoplastic giant cells with high mitotic activity, and osteoclast-like cells; there was marked inflammatory cell infiltration.
  • The anaplastic neoplastic giant cells were immunoreactive for CKpan, CD5, CD45, VIM, and p53.
  • Approximately 50% to 60% of the tumor cells showed immunoreactivity for Ki-67.
  • In situ hybridization for Epstein-Barr virus-encoded RNA was negative for tumor cells and nonneoplastic osteoclastic giant cells.
  • Because this tumor is very rare, extensive clinical, radiological, and morphological examinations as well as immunohistochemical studies are essential to make the diagnosis.
  • [MeSH-major] Carcinoma / pathology. Osteoclasts / pathology. Thoracic Cavity / pathology. Thoracic Neoplasms / pathology. Thymus Neoplasms / pathology

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  • (PMID = 20667924.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Biomarkers, Tumor; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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34. Pouniotis DS, Plebanski M, Apostolopoulos V, McDonald CF: Alveolar macrophage function is altered in patients with lung cancer. Clin Exp Immunol; 2006 Feb;143(2):363-72
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  • [Title] Alveolar macrophage function is altered in patients with lung cancer.
  • We examined patients with lung cancer in order to evaluate the immuno-stimulatory potential of AM in lung cancer.
  • Bronchoalveolar lavage fluid samples were obtained from patients with adenocarcinoma, squamous cell carcinoma, large cell undifferentiated lung carcinoma, small cell carcinoma and control subjects.
  • AM from patients with small and squamous cell carcinoma had impaired uptake in vitro of 40 nm fluorescent polystyrene beads.
  • AM from patients with small, squamous and large cell undifferentiated carcinoma showed impaired uptake of 1000 nm fluorescent polystyrene beads.
  • Secreted levels of TNF-alpha and IL-1 from AM of patients with small, squamous, and large cell undifferentiated carcinoma were decreased compared to controls.
  • Secreted AM IL-6 levels were decreased in small and large cell undifferentiated carcinoma.
  • Phenotypic analysis demonstrated that patients with small cell carcinoma were the only group that showed a decrease in MHC class II surface expression.
  • Surface expression of ICAM-1 and CD83 was decreased on AM from patients with large, squamous and small cell carcinoma compared to controls but not adenocarcinoma.
  • Mannose receptor levels were only decreased on AM from patients with squamous and small cell carcinoma but not adenocarcinoma and large cell undifferentiated carcinoma.
  • We conclude that there are type-specific alterations in uptake ability, cytokine secretion and phenotype of AM from lung cancer patients, which may result in an inability to stimulate anti-tumour immunity.
  • The observed differences between lung cancer subgroups may explain previously reported inconsistencies in descriptions of AM characteristics in lung cancer.
  • [MeSH-major] Lung Neoplasms / immunology. Macrophages / immunology. Pulmonary Alveoli / immunology
  • [MeSH-minor] Adenocarcinoma / immunology. Aged. Antigens, CD / analysis. Biomarkers / analysis. Bronchoalveolar Lavage Fluid / immunology. Carcinoma, Large Cell / immunology. Carcinoma, Small Cell / immunology. Carcinoma, Squamous Cell / immunology. Cytokines / immunology. HLA-DR Antigens / analysis. Humans. Immunoglobulins / analysis. Intercellular Adhesion Molecule-1 / analysis. Lectins, C-Type / analysis. Mannose-Binding Lectins / analysis. Membrane Glycoproteins / analysis. Microspheres. Middle Aged. Phenotype. Polystyrenes / pharmacokinetics. Receptors, Cell Surface / analysis

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  • (PMID = 16412062.001).
  • [ISSN] 0009-9104
  • [Journal-full-title] Clinical and experimental immunology
  • [ISO-abbreviation] Clin. Exp. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers; 0 / CD83 antigen; 0 / Cytokines; 0 / HLA-DR Antigens; 0 / Immunoglobulins; 0 / Lectins, C-Type; 0 / Mannose-Binding Lectins; 0 / Membrane Glycoproteins; 0 / Polystyrenes; 0 / Receptors, Cell Surface; 0 / mannose receptor; 126547-89-5 / Intercellular Adhesion Molecule-1
  • [Other-IDs] NLM/ PMC1809587
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35. Meng Q, Lux A, Holloschi A, Li J, Hughes JM, Foerg T, McCarthy JE, Heagerty AM, Kioschis P, Hafner M, Garland JM: Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. J Biol Chem; 2006 Dec 01;281(48):37069-80
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  • Endoglin is a membrane-inserted protein that is preferentially synthesized in angiogenic vascular endothelial and smooth muscle cells.
  • Although endoglin is known to affect cell responses to TGF-beta, its mode of action is largely unknown.
  • Reverse transcription-PCR showed expression of Tctex2beta in a wide range of tissues, including vascular endothelial and smooth muscle cells, placenta, and testis, as well as in several tumor cell lines.
  • High expression levels were found in human umbilical vein endothelial cells and the large cell lung cancer cell line.
  • [MeSH-minor] Amino Acid Sequence. Animals. Base Sequence. Bone Morphogenetic Protein Receptors, Type II / metabolism. COS Cells. Cercopithecus aethiops. Dyneins. Humans. Mice. Mink. Molecular Sequence Data. NIH 3T3 Cells. Phylogeny. Protein Binding. Sequence Homology, Amino Acid. t-Complex Genome Region

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  • (PMID = 16982625.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ DQ132441
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BBS/B/02436; United Kingdom / Medical Research Council / / G0900414
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Drosophila Proteins; 0 / Dynlt1b protein, mouse; 0 / Microtubule-Associated Proteins; 0 / Nuclear Proteins; 0 / Receptors, Transforming Growth Factor beta; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type II; EC 3.6.4.2 / Dyneins
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36. Vlastos F, Lacomme S, Wild P, Poulain S, Siat J, Grosdidier G, du Manoir S, Monga B, Hillas G, Varsovie R, Claudot F, Marie B, Vignaud JM, Szymanski N: Do evolving practices improve survival in operated lung cancer patients? A biobank may answer. J Thorac Oncol; 2009 Apr;4(4):505-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Do evolving practices improve survival in operated lung cancer patients? A biobank may answer.
  • INTRODUCTION: Biobanks may play a pivotal role in lung cancer patients' management, research, and health policy.
  • The Nancy "Centre of Biologic Resources" analyzed the evolving profiles of operated lung cancer patients and their management over 20 years.
  • RESULTS: After 1997, lung cancer was diagnosed at an earlier stage.
  • For Squamous Cell Lung Cancer (SQCLC), stages IA increased from 5.4 to 19.5% and for Adenocarcinoma (ADC), stage IA increased from 9.9 to 24.7%.
  • More patients with Large Cell Lung Cancer were diagnosed recently.
  • CONCLUSION: Overall and stage-adjusted survival of operated lung cancer patients has been improved in the last decade due mainly to earlier diagnosis.
  • [MeSH-major] Lung Neoplasms / mortality

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  • (PMID = 19240651.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Sato K, Waseda R, Tatsuzawa Y, Soma R, Ueda Y, Katsuda S: Papillary thyroid carcinoma with anaplastic transformation showing a rhabdoid phenotype solely in the cervical lymph node metastasis. Pathol Res Pract; 2006;202(1):55-9
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  • [Title] Papillary thyroid carcinoma with anaplastic transformation showing a rhabdoid phenotype solely in the cervical lymph node metastasis.
  • We describe a rare case of anaplastically transformed papillary thyroid carcinoma with a rhabdoid phenotype appearing solely in a metastatic focus.
  • Examination of surgically resected specimens disclosed that the thyroid tumor was a well-differentiated papillary carcinoma (2.0 cm in diameter), and the right lateral cervical mass was an anaplastic carcinoma (2.4 cm in diameter) showing a rhabdoid phenotype with scant amounts of a papillary carcinoma component in the periphery, considered to be transformed through the metastasis of the papillary thyroid carcinoma in a cervical lymph node.
  • The rhabdoid cells had eccentric nuclei with conspicuous nucleoli and spherical hyaline cytoplasmic inclusions, which are immunoreactive for vimentin and sarcomeric actin.
  • [MeSH-major] Carcinoma, Papillary / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Aged. Biomarkers, Tumor. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Lymph Nodes. Lymphatic Metastasis. Male. Rhabdoid Tumor

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  • (PMID = 16310972.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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38. Franks TJ, Galvin JR: Sarcomatoid carcinoma of the lung: histologic criteria and common lesions in the differential diagnosis. Arch Pathol Lab Med; 2010 Jan;134(1):49-54
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  • [Title] Sarcomatoid carcinoma of the lung: histologic criteria and common lesions in the differential diagnosis.
  • CONTEXT: Sarcomatoid carcinoma of the lung is a subset of poorly differentiated non-small cell lung cancers that are diagnostically challenging because they are uncommon, may reveal little of their parent cell of origin, and overlap morphologically with other anaplastic epithelioid and spindle cell tumors that can be primary in, or metastatic to, the lung and pleura.
  • OBJECTIVE: To review the current histologic classification and diagnostic criteria that identify the 5 subtypes of sarcomatoid carcinoma of the lung and to discuss the most common tumors in the differential diagnosis.
  • CONCLUSIONS: Identification of sarcomatoid carcinoma of the lung requires knowledge of specific histologic criteria that define the 5 subgroups, targeted immunohistochemical studies, and correlation with chest imaging to assess distribution of disease and to avoid misdiagnosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Sarcoma / diagnosis. Sarcoma / pathology

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  • (PMID = 20073605.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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39. Kasprzak A, Zabel M, Biczysko W: Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocrine pulmonary tumours. Pol J Pathol; 2007;58(1):23-33
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  • [Title] Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocrine pulmonary tumours.
  • Neuroendocrine tumours of lungs represent a subgroup of pulmonary tumours with typical morphofunctional traits.
  • In light microscopy, the four principal types of the tumours (typical and atypical carcinoids, small cell lung cancer, large cell neuroendocrine carcinoma) demonstrate typical arrangement of cells (organoid nesting, palisading, a trabecular pattern, and rosette-like structures), variable number of mitoses, presence or absence of necrosis.
  • In ultrastructure, neuroendocrine tumours manifest groups of cells with cytoplasmic granules (and the so called dense-core neurosecretory granules in particular).
  • Neuroendocrine cells release hormones to circulation or in a paracrine manner.
  • Until now, the most sensitive and specific marker or marker combination for early detection of neuroendocrine subtypes of lung tumours has not been identified.
  • Both in endocrine and non-endocrine tumours, neuron-specific enolase (NSE) is thought to represent mainly a prognostic index, and only quantitation of serum concentrations of the protein or of the fraction of immunopositive cells may permit to differentiate between subtypes of the tumours.
  • With increasing frequency, PGP 9.5 is regarded to provide a prognostic marker in diagnosis of non-small cell lung carcinomas rather than of typical neuroendocrine tumours.
  • [MeSH-major] Chromogranin A / metabolism. Lung Neoplasms / diagnosis. Neuroendocrine Tumors / diagnosis. Phosphopyruvate Hydratase / metabolism. Synaptophysin / metabolism. Ubiquitin Thiolesterase / metabolism

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  • (PMID = 17585539.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Synaptophysin; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 114
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40. Khan N, Oriuchi N, Higuchi T, Endo K: Review of fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in the follow-up of medullary and anaplastic thyroid carcinomas. Cancer Control; 2005 Oct;12(4):254-60
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  • [Title] Review of fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in the follow-up of medullary and anaplastic thyroid carcinomas.
  • BACKGROUND: The goal of posttreatment follow-up for medullary and anaplastic thyroid cancer (MTC and ATC) is the early diagnosis of recurrence or metastases.
  • However, the PET technique is limited by less accurate spatial assignment of small lesions, especially in the lung and liver.
  • [MeSH-major] Carcinoma / radionuclide imaging. Carcinoma, Medullary / radionuclide imaging. Fluorodeoxyglucose F18. Radiopharmaceuticals. Thyroid Neoplasms / radionuclide imaging

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  • (PMID = 16258498.001).
  • [ISSN] 1073-2748
  • [Journal-full-title] Cancer control : journal of the Moffitt Cancer Center
  • [ISO-abbreviation] Cancer Control
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 45
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41. Pavićević R, Bubanović G, Franjević A, Stancić-Rokotov D, Samarzija M: CYFRA 21-1 in non-small cell lung cancer--standardisation and application during diagnosis. Coll Antropol; 2008 Jun;32(2):485-98
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  • [Title] CYFRA 21-1 in non-small cell lung cancer--standardisation and application during diagnosis.
  • Standardisation is achieved by determining the reference range in asymptomatic population, benign and malignant lung diseases, and benign and malignant diseases of other organs.
  • The cut-off level of CYFRA 21-1 for non-small cell lung cancer (NSCLC) is 1.72 ng/mL in the Croatian population.
  • It is based on the clinically applicable sensitivity of 78% and specificity of 95% in benign lung diseases.
  • For clinicians the level of CYFRA 21-1 is an early sign of NSCLC in relation to all the benign lung diseases and all the benign diseases of other organs, of which it was confirmed that they can influence the above level, provided that NSCLC is verified using standard diagnostic methods.
  • The sensitivity of CYFRA 21-1 in NSCLC is 78%, in squamous cell lung cancer (SQC) 84.6%, in adenocarcinomas (AD) 74.3% and in large cell lung cancer (LCC) 75.3%.
  • The level of CYFRA 21-1 prompts clinicians to repeat the clinical procedure during diagnosis, and helps to detect the disease earlier and implement treatment in NSCLC.
  • [MeSH-major] Antigens, Neoplasm / blood. Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / diagnosis. Keratins / blood. Lung Neoplasms / diagnosis

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  • (PMID = 18756899.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Keratin-19; 0 / antigen CYFRA21.1; 68238-35-7 / Keratins
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42. Swann MH, Yoon J: Merkel cell carcinoma. Semin Oncol; 2007 Feb;34(1):51-6
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  • [Title] Merkel cell carcinoma.
  • Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous cancer that predominately affects elderly Caucasians with fair skin and has a propensity for local recurrence and regional lymph node metastases.
  • A variety of terms have been used to describe this tumor, including trabecular cell carcinoma, neuroendocrine or primary small cell carcinoma of the skin, and anaplastic cancer of the skin.
  • It may be difficult to accurately diagnose MCC by light microscopy alone and ancillary techniques, including electron microscopy and immunohistochemistry, may be necessary to make a definitive diagnosis.
  • Systemic chemotherapy, akin to regimens for small cell carcinoma of the lung, may be considered as an adjuvant following surgery or to treat locoregional or distant disease.
  • Successful outcomes are most often seen in patients with early diagnosis and complete excision.
  • [MeSH-major] Carcinoma, Merkel Cell. Skin Neoplasms
  • [MeSH-minor] Aged. Combined Modality Therapy. Humans. Lymphatic Metastasis. Neoplasm Recurrence, Local / diagnosis. Prognosis. Treatment Outcome

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  • (PMID = 17270666.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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43. Petrović M, Tomić I, Ilić S: [Neuroendocrine differentiation as a survival prognostic factor in advanced non-small cell lung cancer]. Vojnosanit Pregl; 2007 Aug;64(8):525-9
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  • [Title] [Neuroendocrine differentiation as a survival prognostic factor in advanced non-small cell lung cancer].
  • BACKGROUND/AIM: Neuroendrocine lung tumors are histologically heterogenous group of cancers with different clinical progression.
  • In non-small cell lung cancer (NSCLC) neuroendocrine differentiation exists in 10-30% of patients.
  • The aim of this study was to determine the frequency and influence of neuroendocrine differentiation on survival of treated patients with advanced non-small cell lung cancer (NSCLC).
  • METHODS: A clinical trial included 158 patients (74% males and 26% females), with the diagnosis of NSCLC, determined by histological verification.
  • RESULTS: A total of 53 patients (34%) had NSCLC with neuroendocrine differentiation, confirmed rather in large cell lung cancer and lung adenocarcinoma (66.7% and 40%, respectively).
  • One year follow-up survival time was longer in the patients with neuron specific enolase and chromogranin A expression lung cancer (p < 0.001).
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Chromogranin A / analysis. Lung Neoplasms / mortality. Phosphopyruvate Hydratase / analysis. Synaptophysin / analysis

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  • (PMID = 17874719.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / Synaptophysin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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44. Lin JD, Chao TC: Follicular thyroid carcinoma: From diagnosis to treatment. Endocr J; 2006 Aug;53(4):441-8
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  • [Title] Follicular thyroid carcinoma: From diagnosis to treatment.
  • Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally.
  • This implies how difficult it is to diagnosis this type of cancer at the pre-operative or intra-operative stage of treatment.
  • Fine needle aspiration cytology has been shown to be an ineffective method for diagnosing vascular or capsule invasion of follicular thyroid cancer.
  • Although radioactive iodide (131I) has been used as the standard treatment for follicular thyroid carcinoma with distant metastases, the effectiveness of 131I treatment for follicular thyroid carcinoma depends on the differentiation of cancer cells.
  • The possibility of 131I for thyroid remnant ablation replacing a secondary operation for follicular thyroid carcinoma has been debated.
  • Recent studies applied more expressions of sodium iodide symporters to attain the effect of 131I treatment and slow the proliferation of thyroid cancer cell which, in turn, slows the progression of follicular carcinoma.
  • Consensus for the surgical procedures for the specific prognostic risks for follicular thyroid carcinoma is needed.
  • Dedifferentiated, anti-angiogenic, or gene therapies for follicular thyroid cancer with distant metastases or anaplastic transformation comprise the principal directions in future research for this cancer.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / therapy. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / therapy
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Carcinoma, Papillary / therapy. Diagnostic Imaging. Humans. Iodine Radioisotopes / therapeutic use. Predictive Value of Tests. Thyroidectomy

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  • (PMID = 16807500.001).
  • [ISSN] 0918-8959
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Iodine Radioisotopes
  • [Number-of-references] 72
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45. Shindo G, Endo T, Onda M, Shimada T, Inou T, Hiruta H: [Pulmonary large cell carcinoma contiguous to bullae with massive bullous hematoma and hemoptysis; with special reference to 20 cases of Japanese reports]. Kyobu Geka; 2005 Aug;58(9):787-93
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  • [Title] [Pulmonary large cell carcinoma contiguous to bullae with massive bullous hematoma and hemoptysis; with special reference to 20 cases of Japanese reports].
  • A 50-year-old man with continuous hemosputa and large hematoma of left upper lobe contiguous to bilateral emphysematous bullous disease was admitted for surgery to stop hemorrhage and to resect left lung hematoma and multiple bullae.
  • Pathological examination, however, revealed anaplastic carcinoma inside bulla of S(1+2)c with minimal invasion into adhered parietal pleura (p 3).
  • The final pathological diagnosis was large cell carcinoma of left S(1+2)c with the staging pT3N0M0 and stage II.
  • Clinical analysis of Japanese 20 cases of lung carcinoma with initial signs of hemosputa and/or hemoptysis contiguous to emphysematous bullae elucidate following important facts.
  • Hemosputa and hemoptysis play important role for early finding and diagnosis of lung cancer contiguous to bullous disease, especially in patients of early clinical stage with or without computed tomography (CT) exams and promise to better surgical prognosis and survivals as compared with non hemosputa ones.
  • [MeSH-major] Blister / surgery. Carcinoma, Large Cell / diagnosis. Hematoma / surgery. Lung Diseases / surgery. Lung Neoplasms / diagnosis. Pneumonectomy

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  • (PMID = 16104563.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 25
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46. Cannizzo E, Sohani AR, Ferry JA, Hochberg EP, Kluk MJ, Dorn ME, Sadowski C, Bucci JJ, Ackerman AM, Longtine JA, Carulli G, Preffer FI: Carcinoma and multiple lymphomas in one patient: establishing the diagnoses and analyzing risk factors. J Hematop; 2009;2(3):163-70
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  • [Title] Carcinoma and multiple lymphomas in one patient: establishing the diagnoses and analyzing risk factors.
  • We report the case of a patient who showed the sequential occurrence of four different lymphoid neoplasms together with a squamous cell carcinoma of the lung.
  • Two years later, a PET-CT scan showed a left hilar mass in the lung; biopsy showed a squamous cell carcinoma.
  • Simultaneously, he was diagnosed with diffuse large B cell lymphoma in a neck lymph node; after chemo- and radiotherapy, he achieved a complete response.
  • A restaging PET-CT scan 2 years later revealed a retroperitoneal nodule, and biopsy again showed a low-grade follicular lymphoma, while a biopsy of a cutaneous scalp lesion showed a CD30-positive peripheral T cell lymphoma.
  • After some months, a liver biopsy and a right cervical lymph node biopsy showed a CD30-positive peripheral T cell lymphoma consistent with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma.
  • Flow cytometry and cytogenetic and molecular genetic analysis performed at diagnosis and during the patient's follow-up confirmed the presence of two clonally distinct B cell lymphomas, while the two T cell neoplasms were confirmed to be clonally related.

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  • [Cites] Obstet Gynecol. 2002 Nov;100(5 Pt 2):1079-82 [12423812.001]
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  • (PMID = 20309424.001).
  • [ISSN] 1865-5785
  • [Journal-full-title] Journal of hematopathology
  • [ISO-abbreviation] J Hematop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2766444
  • [Keywords] NOTNLM ; Anaplastic large cell lymphoma / Cytogenetics / Diffuse large B cell lymphoma / Follicular lymphoma / Multiple malignancies / Risk factors
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47. Vassilatou E, Fisfis M, Morphopoulos G, Savva S, Voucouti E, Stefanoudaki K, Tzavara I: Papillary thyroid carcinoma producing granulocyte-macrophage colony-stimulating factor is associated with neutrophilia and eosinophilia. Hormones (Athens); 2006 Oct-Dec;5(4):303-9
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  • [Title] Papillary thyroid carcinoma producing granulocyte-macrophage colony-stimulating factor is associated with neutrophilia and eosinophilia.
  • Thyroid tumors producing colony-stimulating factors associated with neutrophilia and/or eosinophilia are very rare and almost all of them concern anaplastic thyroid cancer.
  • Only one case of papillary thyroid carcinoma associated with neutrophilia and one case of medullary thyroid carcinoma associated with eosinophilia have been reported.
  • In this report a 72-year old male patient with metastatic papillary thyroid carcinoma associated with neutrophilia and eosinophilia is described.
  • While investigating the cause of neutrophilia and eosinophilia, a blind bone marrow biopsy of the posterior iliac crest was performed, which showed infiltration by papillary thyroid carcinoma.
  • As other causes of neutrophilia and eosinophilia were excluded, we assumed that these were paraneoplastic manifestations induced by GM-csF produced by the thyroid tumor. the disease progressed rapidly, despite appropriate treatment which included thyroidectomy and postoperative radioactive (131)I administration. the patient died 11 months after diagnosis because of extensive lung metastasis.
  • Neutrophilia and eosinophilia were stable findings, while serum thyroglobulin levels remained elevated throughout the follow-up period. to our knowledge, this is the first report of a patient with metastatic papillary thyroid carcinoma in whom neutrophilia and eosinophilia associated with high circulating levels of GM-csF were detected.
  • [MeSH-major] Carcinoma, Papillary / pathology. Eosinophils / pathology. Granulocyte-Macrophage Colony-Stimulating Factor / blood. Neutrophils / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Eosinophilia / diagnosis. Eosinophilia / etiology. Eosinophilia / pathology. Humans. Male

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  • (PMID = 17178706.001).
  • [ISSN] 1109-3099
  • [Journal-full-title] Hormones (Athens, Greece)
  • [ISO-abbreviation] Hormones (Athens)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
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48. Gurbuz Y, Kose N, Aydin O, Ozturk M: An immunohistochemical profile of giant cell carcinoma of the larynx. Auris Nasus Larynx; 2007 Sep;34(3):413-6

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  • [Title] An immunohistochemical profile of giant cell carcinoma of the larynx.
  • OBJECTIVE: This report describes a case of a 62-year-old male with giant cell carcinoma of the larynx that presented as a neck mass and hoarseness.
  • Microscopical examination showed that the tumor was composed of solid masses of anaplastic small cells with hyperchromatic nuclei.
  • There were multinucleated giant cells with huge nuclei, prominent nucleoli, and clear or eosinophylic cytoplasm.
  • The diagnosis of giant cell carcinoma of the larynx was made.
  • CONCLUSION: Giant cell carcinoma of the larynx is an extremely rare tumor the origin of which is not clearly understood.
  • It is believed to be the counterpart of giant cell carcinoma of the lung in larynx.
  • In conclusion, giant cell carcinoma of the larynx is confirmed to be a specific entity of simple epithelial origin and it is the counterpart of giant cell carcinoma of the lung.
  • [MeSH-major] Carcinoma, Giant Cell / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 17376621.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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49. Wang CY, Lin KH, Yang CJ, Tsai JR, Hung JY, Wang PH, Hsu HK, Huang MS: Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma. Kaohsiung J Med Sci; 2010 Feb;26(2):68-75
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  • [Title] Toona sinensis extracts induced cell cycle arrest and apoptosis in the human lung large cell carcinoma.
  • Toona sinensis extracts have been shown to exhibit anti-cancer effects in human ovarian cancer cell lines, human promyelocytic leukemia cells and human lung adenocarcinoma.
  • However, its anti-cancer properties in human lung large cell carcinoma have not been studied.
  • Here, we used a powder obtained by freeze-drying the supernatant of centrifuged crude extract from Toona sinensis leaves (TSL-1) to treat the human lung carcinoma cell line H661.
  • Cell viability was evaluated by the 3-(4-,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide assay.
  • Flow cytometry analysis revealed that TSL-1 blocked H661 cell cycle progression.
  • Western blot analysis showed decreased expression of cell cycle proteins that promote cell cycle progression, including cyclin-dependent kinase 4 and cyclin D1, and increased the expression of proteins that inhibit cell cycle progression, including p27.
  • Furthermore, flow cytometry analysis showed that TSL-1 induced H661 cell apoptosis.
  • Western blot analysis showed that TSL-1 reduced the expression of the anti-apoptotic protein B-cell lymphoma 2, and degraded the DNA repair protein, poly(ADP-ribose) polymerase.
  • TSL-1 shows potential as a novel therapeutic agent or for use as an adjuvant for treating human lung large cell carcinoma.
  • [MeSH-major] Apoptosis / drug effects. Carcinoma, Large Cell / physiopathology. Cell Cycle / drug effects. Lung Neoplasms / physiopathology. Meliaceae / chemistry. Plant Extracts / pharmacology
  • [MeSH-minor] Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Gene Expression Regulation / drug effects. Humans

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  • (PMID = 20123594.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Plant Extracts
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50. Sasaki T, Rodig SJ, Chirieac LR, Jänne PA: The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer; 2010 Jul;46(10):1773-80
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  • [Title] The biology and treatment of EML4-ALK non-small cell lung cancer.
  • The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs).
  • EML4-ALK is most often detected in never smokers with lung cancer and has unique pathologic features.
  • This review will focus on the biology, clinical characteristics, diagnosis and treatment of EML4-ALK NSCLC.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20418096.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA136851-02; United States / NCI NIH HHS / CA / R01 CA136851; United States / NCI NIH HHS / CA / R01 CA136851-02; United States / NCI NIH HHS / CA / R01CA136851
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / EML4-ALK fusion protein, human; 0 / Enzyme Inhibitors; 0 / Oncogene Proteins, Fusion; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
  • [Other-IDs] NLM/ NIHMS195408; NLM/ PMC2888755
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51. Liao L, Zhou Q, Chen J, Zhu D, Ma L, Yan H, Zhu W, Liu H: [Construction and screening of the subtracted cDNA library of human large cell lung cancer lines with different metastatic potentials]. Zhongguo Fei Ai Za Zhi; 2007 Jun 20;10(3):163-7

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  • [Title] [Construction and screening of the subtracted cDNA library of human large cell lung cancer lines with different metastatic potentials].
  • BACKGROUND: Screening metastatic-related genes of lung cancer is helpful to understand the molecular mechanisms of lung cancer invasion and metastasis.
  • In order to screen the differential expression genes related to metastasis of lung cancer, we constructed and preliminarily screened the subtracted cDNA libraries of human large cell lung cancer cell lines with different metastatic potentials in this study.
  • METHODS: Subtracted cDNA library was constructed in the different metastastic potential cell lines NL9980 and L9981 by suppression subtractive hybridization (SSH) method.
  • RESULTS: The subtracted cDNA libraries were successfully constructed in the different metastastic potential cell lines NL9980 and L9981.
  • The forward and reverse subtracted cDNA libraries of different metastastic potential cell lines are constructed by this method.
  • The differential expression genes related to tumor metastasis might exist in the human large cell lung cancer cell lines with different metastasis potential.

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  • (PMID = 21118638.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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52. Nie Q, Zhu W, Liu L, Fu J, Li D, Li Y, Chen J, Liu H, Zhou Q: [The mechanism and influence on the biological behavior of human high-metastatic large cell lung cancer cell lines with transfection of nm23-H1 gene.]. Zhongguo Fei Ai Za Zhi; 2008 Jun 20;11(3):349-53
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  • [Title] [The mechanism and influence on the biological behavior of human high-metastatic large cell lung cancer cell lines with transfection of nm23-H1 gene.].
  • The aim of this study is to compare the biological behavior changes among three human high-metastatic large cell lung cancer cell lines which transfected and untransfected nm23-H1 gene, and to study the mechanism of nm23-H1 gene supressing the metastasis.
  • METHODS: Boyden Chamber and MTT method were used to detect the rates of invasion and proliferation among different human pulmonary carcinoma cells of transfected and untransfected nm23-H1 gene; meanwhile The three lung cancer cell lines were treated with PKC inhibitor Calphostin C, and the above measurements were also performed.
  • RESULTS: The ability of invasion and proliferation of L9981 and L9981-PLXSN human high-metastatic large cell lung cancer cells,which lack of nm23-H1gene, was higher than that of L9981-nm23-H1 human high-metastatic large cell line, which transfected with nm23-H1gene (P <0.001).
  • There was no difference beteween L9981 and L9981-PLXSN cell lines (P >0.05).
  • After treated with PKC inhibitor Calphstin C,the invasion and proliferation ability of three lung cancer cell lines were obviously go down (P <0.001), however, the invasion and proliferation ability of L9981-nm23-H1 lung cancer cell line was still lower than those of L9981 and L9981-PLXSN lung cancer cell lines (P <0.001), and there was also no significant difference between two later cell lines (P >0.05).
  • CONCLUSIONS: Our data suggest that nm23-H1 gene can significantly inhibit the cell proliferation and invasion in L9981 lung cancer line.
  • The effect of nm23-H1 might be correlated with downregulation of PKC signal transduction in human high-metastatic large cell lung cancer cell line.

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  • (PMID = 20731932.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Liang HH, Wu CH, Tam KW, Chai CY, Lin SE, Chen SC: Thyroid metastasis in a patient with hepatocellular carcinoma: case report and review of literature. World J Surg Oncol; 2007;5:144
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  • [Title] Thyroid metastasis in a patient with hepatocellular carcinoma: case report and review of literature.
  • BACKGROUND: Despite the apparent low incidence of cancer metastatic to the thyroid, autopsy and clinical series suggest it is more common than generally.
  • Although lung, renal, and breast cancer are probably the most common primary sites, a number of cancers have been reported to metastasize to the thyroid synchronously with diagnosis of primary tumor or years after apparently curative treatment.
  • CASE PRESENTATION: We report a rare case of a hepatocellular carcinoma metasatic to the thyroid.
  • The patient presented seven months after original diagnosis and treatment with hepatic lobectomy with multiple neck lesions producing a mass effect on the trachea and bilateral lymphadenopathy.
  • Fine-needle aspiration revealed highly anaplastic carcinoma, and immunohistochemistry confirmed hepatocellular carcinoma.
  • CONCLUSION: Clinicians should consider the possibility of metastatic cancer in each patient who presents with a new thyroid mass, especially those with a history of cancer, however remote.
  • In cases where cytology or histology is not diagnostic, immunohistochemistry may be definitive in making the diagnosis.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Hepatocellular / secondary. Liver Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • (PMID = 18157914.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2246133
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54. Makdissi A, Zimmerman RS: Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature. Endocr Pract; 2007 Jul-Aug;13(4):389-95
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  • [Title] Humoral hypercalcemia of malignancy in a patient with large cell carcinoma of the lung: report of case and review of literature.
  • OBJECTIVE: To report a case of hypercalcemia associated with parathyroid hormone-related protein (PTHrP) in large cell carcinoma of the lung.
  • METHODS: We present a case of PTHrP-mediated hypercalcemia in a patient with a large cell carcinoma of the lung and review the related literature.
  • Breath sounds were decreased in the left lower lung field.
  • Computed tomographic scans of the chest showed a large complex lesion in the left lower hemithorax, a small right pleural effusion, and extensive pulmonary emphysema bilaterally.
  • Open lung biopsy revealed a large cell undifferentiated carcinoma.
  • CONCLUSION: Although the finding is rare, patients with large cell carcinoma of the lung and hypercalcemia may have humoral hypercalcemia mediated by PTHrP.
  • [MeSH-major] Carcinoma, Large Cell / complications. Hypercalcemia / etiology. Lung Neoplasms / complications. Parathyroid Hormone-Related Protein / blood

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  • (PMID = 17669716.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein
  • [Number-of-references] 31
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55. Liu J, Zhong X, Zhou Q, Gao AC, Wang Y, Zhu W, Ma L, Zhang Z: [Primary experimental results of methylseleninic acid on the proliferation inhibition and apoptotic induction in human high-metastatic large cell lung cancer cell line L9981]. Zhongguo Fei Ai Za Zhi; 2006 Apr 20;9(2):103-8
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  • [Title] [Primary experimental results of methylseleninic acid on the proliferation inhibition and apoptotic induction in human high-metastatic large cell lung cancer cell line L9981].
  • BACKGROUND: It has been proved that selenium has remarkable effects in the prevention of cancer and proliferation inhibition for breast cancer and prostate cancer.
  • Up to now, little is known, however, if methylseleninic acid (MSA) has the anticancer effect on lung cancer or not.
  • The objective of this study is to detect the effect of MSA on proliferation inhibition and apoptotic induction for human high-metastatic large cell lung cancer cell line L9981, and to explore the molecular mechanisms.
  • METHODS: The changes of proliferation, clone formation, apoptotic level and cell cycles were detected in L9981 by trypan blue staining, clone formation suppression test, and flow cytometry before and after treating with different concentration of MSA.
  • RESULTS: (1)The proliferation ability of L9981 was remarkably inhibited at the concentration of 0.5μmol/L of MSA (P < 0.05), and the cells were arrested at G0/G1 phase after treating with the same concentration. (2)Apoptosis of L9981 was remarkably induced by MSA at the concentration of 2.5μmol/L (P < 0.05). (3)The clone formation ability of L9981 was significantly suppressed by MSA at the concentration of 5.0μmol/L (P < 0.05). (4)The expression levels of P53, P21, Fas, FasL and Bax were remarkably up-regulated after treatment with MSA.
  • CONCLUSIONS: (1)MSA can significantly suppress the proliferation and clone formation ability of human high-metastatic large cell lung cancer cell line L9981, and also induce apoptosis of L9981. (2)The anticancer effects of MSA might be related to regulate the expression of cell cycle-related genes and apoptotic-related genes in the human high-metastatic large cell lung cancer line L9981.

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  • (PMID = 21144291.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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56. Ma L, Zhou Q, Zhu W, Zhu D, Yang X, Wang Y, Chen X, Zhang M, Gao L, Zhap Y: [Effects of nm23-H1 point mutation on activity of GSK-3β in human high-metastatic large cell lung cancer cell line L9981]. Zhongguo Fei Ai Za Zhi; 2006 Feb 20;9(1):30-4
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  • [Title] [Effects of nm23-H1 point mutation on activity of GSK-3β in human high-metastatic large cell lung cancer cell line L9981].
  • BACKGROUND: The results of our previous studies have proven that nm23-H1 gene can suppress metastasis of lung cancer, which may be associated with suppression of the Wnt signal pathway through up-regulating the activity of glycogen synthase kinase 3β (GSK-3β), the key kinase of the Wnt signal pathway.
  • The aim of this study is to investigate the effect of point mutation of nm23-H1 gene on GSK-3β activity in cytoplasm and nucleus in human high-metastatic large cell lung cancer cell line L9981.
  • METHODS: Using immunoprecipitation and a radioactive isotope scintillation counter, the activity of GSK-3β was detected in cytoplasm and nucleus of human low-metastatic large cell lung cancer cell line NL9980, human high-metastatic large cell lung cancer cell line L9981, L9981-pEGFP (transfected with vector), L9981-nm23-H1-pEGFP (transfected with wild type nm23-H1), L9981-nm23-H1 S44A -pEGFP mutant (transfected with serine 44 to alanineon of nm23-H1 gene), L9981-nm23-H1 P96S -pEGFP mutant (transfected with proline 96 to serine of nm23-H1 gene), L9981-nm23-H1 H118F -pEGFP mutant (transfected with histidine 118 to phenylalanine of nm23-H1 gene) and L9981-nm23-H1 S120G -pEGFP mutant (transfected with serine 120 to glycine of nm23-H1 gene).
  • RESULTS: The GSK-3β activity in cytoplasm and nucleus was remarkably decreased in the transgene lung cancer cell lines transfected with mutant nm23-H1 cDNA (L9981-nm23-H1 S44A -pEGFP, L9981-nm23-H1 P96S -pEGFP, L9981-nm23-H1 H118F -pEGFP and L9981-nm23-H1 S120G -pEGFP).
  • Significant differences of GSK-3β activity in cytoplasm and nucleus were observed (P < 0.05) when L9981-nm23-H1-pEGFP cell line was compared with L9981-nm23-H1 S44A -pEGFP, L9981-nm23-H1 P96S -pEGFP, L9981-nm23-H1 H118F -pEGFP and L9981-nm23-H1 S120G -pEGFP lung cancer cell lines.
  • There was a highly significant difference in GSK-3β activity in the cytoplasm between L9981-nm23-H1-pEGFP cell line and L9981-nm23-H1 P96S -pEGFP lung cancer cell line (P < 0.01 ).
  • A highly significant difference in GSK-3β activity in the nucleus was observed (P < 0.01) when L9981-nm23-H1-pEGFP lung cancer cell line was compared with L9981-nm23-H1 S44A -pEGFP, L9981-nm23-H1 P96S -pEGFP and L9981-nm23-H1 H118F -pEGFP lung cancer cell lines. CONCLUSIONS:.
  • (1) Point mutation of nm23-H1 gene can significantly influence the regulating effects on the GSK-3β activity in the cytoplasm and nucleus in the human high-metastatic large cell lung cancer cell line L9981. (2) The effects of nm23-H1 gene on metastatic phenotype may be related to the upregulation of GSK-3β activity in human high-metastatic large cell lung cancer cell line L9981.

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  • (PMID = 21144278.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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57. Lv H, Yan H, Wang M, Li Y, Wan H, Liu H, Wu H, Zhou Q: [Methylation profile difference in human high-metastatic large cell lung cancer cell line L9981 and low-metastatic large cell lung cancer line NL9980]. Zhongguo Fei Ai Za Zhi; 2010 Aug;13(8):763-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Methylation profile difference in human high-metastatic large cell lung cancer cell line L9981 and low-metastatic large cell lung cancer line NL9980].
  • BACKGROUND AND OBJECTIVE: Invasion and metastasis is one of malignant phenotype of lung cancer and the important cause of the death of lung cancer patients.
  • The aim of this study is to explore the methylation profile difference in different metastatic potential cell lines.
  • METHODS: To compare the DNA methylation profile of two large cell lung cancer cell lines with different metastatic potential by MeIP chip hybridization, hypermethylated and hypomethylated genes of L9981 cell lines were analyzed online in NIH-DAVID, KEGG and MILANO webside.
  • RESULTS: Compared with NL9980 cell line, 735 genes are hypermethylated in L9981, including 656 known genes and 79 unknown genes; 809 gene are hypermethylated in L9981, including 698 known genes and 111 unknown genes; the different genes are involved in cell process, signal transduction, cell communication, cell adhesion, cell motility, and angiogenesis.
  • CONCLUSION: Hypermethylation of suppressor genes and negative regulator of signal transduction and hopomethylation of oncogene and cell adhesion molecules (CAMs) in L9981 may promote metastasis of tumor cells.
  • [MeSH-major] Carcinoma, Large Cell / metabolism. DNA Methylation. Lung Neoplasms / metabolism
  • [MeSH-minor] Cell Line, Tumor. Humans. Neoplasm Metastasis

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  • (PMID = 20704814.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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58. Zhang Z, Fan Y, Zhou Q, Wang Y, Ma L, Chen X, Zhu W, Yang X, Zhao Y: [Effects of polysaccharid on expression of angiogenic-related genes in human high-metastatic large cell lung cancer cell line L9981]. Zhongguo Fei Ai Za Zhi; 2006 Apr 20;9(2):137-42
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  • [Title] [Effects of polysaccharid on expression of angiogenic-related genes in human high-metastatic large cell lung cancer cell line L9981].
  • BACKGROUND: Lung cancer is one of the most malignant cancers which is hazarding the people's health and life in the world.
  • The aim of this study is to observe the effects of polysaccharid (PS-T) on expression of angiogenic-related gene mRNA in human high-metastatic large cell lung cancer cell line L9981, and to explore its possible molecular mechanism.
  • CONCLUSIONS: (1)PT-S could inhibit the growth of human high-metastatic large cell lung cancer cell line L9981 in vitro, the effect is dose-dependent. (2)PS-T can down- or up-regulate the mRNA transcript expression of some angiogenic-related gene mRNA. (3)PS-T has remarkably coordinating effects with cisplatin in the L9981 lung cancer cell line.

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  • (PMID = 21144298.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Gao L, Zhu W, Li L, Hou M, Ma L, Zhao Y, Zhou Q: [Comparative proteomics study on human high-metastatic large cell lung cancer cell lines before and after transfecting with nm23-H1 gene]. Zhongguo Fei Ai Za Zhi; 2010 Oct;13(10):928-32
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  • [Title] [Comparative proteomics study on human high-metastatic large cell lung cancer cell lines before and after transfecting with nm23-H1 gene].
  • The aim of this study is to better understand the mechanism of lung cancer metastasis and to find new biomarkers for early diagnosis and new target for therapy by conducting comparative proteomics between the human high-metastatic large cell lung cancer cell lines (L9981) and L9981-nm23-H1 (constructed with transfecting nm23-H1 gene into the L9981 cell line).
  • METHODS: The total proteins of L9981 and L9981-nm23-H1 were separated by immobilized pH gradient (IPG)-based 2-dimensional electrophoresis (2-DE); the significantly differently expressed proteins were examined by mass spectrometry and analyzed by bioinformatics.
  • RESULTS: It was observed that nm23-H1 gene transfection caused remarkable changes of the proteome of L9981 compared with L9981-nm23-H1 cells: 5 proteins were deleted, 9 proteins appeared, 16 proteins downregulated, and 12 proteins up-regulated.
  • These proteins are involved in cell framework, signal transduction, metabolism, proliferation and metastasis.
  • These changes of the proteome could serve as a basis for reversing the invasive and metastatic phenotype in lung cancer and elucidating the mechanisms of the metastasis of lung cancer.
  • [MeSH-major] Carcinoma, Large Cell / metabolism. Carcinoma, Large Cell / pathology. Lung Neoplasms / metabolism. Lung Neoplasms / pathology. NM23 Nucleoside Diphosphate Kinases / genetics. Proteomics / methods. Transfection
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Line, Tumor. Early Detection of Cancer. Humans. Neoplasm Metastasis

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  • (PMID = 20959063.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / NM23 Nucleoside Diphosphate Kinases; EC 2.7.4.6 / NME1 protein, human
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60. Liu C, Chen J, Wu Z, Li Y, Zhu Y, Ren Y, Zhou Q: [Selenium compounds induce ROS in human high-metastatic large cell lung cancer cell line L9981.]. Zhongguo Fei Ai Za Zhi; 2008 Jun 20;11(3):354-8

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  • [Title] [Selenium compounds induce ROS in human high-metastatic large cell lung cancer cell line L9981.].
  • BACKGROUND: It has been proved that methylseleninic acid (MSA) is a kind of artificially developed selenium compound, which appeared to be the best candidate for cancer prevention and therapy.
  • METHODS: We confirmed that MSA and selenite have the anticancer effect in the human high-metastatic large cell lung cancer cell line L9981 by growth inhibition detection, we detect the ROS induced by MSA and selenite in L9981 by fluorescence microscopy, and use flow cytometry to quantitate the ROS induced by NAC together with selenium compounds.
  • CONCLUSIONS: (1)MSA and selenite had anti-L9981 effect. (2)Oxidative stress reaction may participate in the induction of apoptosis by MSA and selenite in lung cancer cell line L9981.

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  • (PMID = 20731933.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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61. Li Y, Zhou Q, Sun Z, Sun Z, Wang Y, Qin Y, Zhu W, Chen X: [Experimental study on molecular mechanism of nm23-H1 gene transfection reversing the malignant phenotype of human high-metastatic large cell lung cancer cell line]. Zhongguo Fei Ai Za Zhi; 2006;9(4):307-11
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  • [Title] [Experimental study on molecular mechanism of nm23-H1 gene transfection reversing the malignant phenotype of human high-metastatic large cell lung cancer cell line].
  • Our previous study has found that transfection of wild type nm23-H1 gene can significantly downregulate the ERK1/2 activity of human high-metastatic large cell lung cancer cell line L9981.
  • The aim of this study is to investigate the influence of nm23-H1 and exogenous ERK1/2 pathway inhibitor U0126 on the extracellular signal-regulated kinase (ERK1/2) of human high-metastatic large cell lung cancer cell line L9981 and its malignant biological behaviors.
  • METHODS: The expressive levels of total-ERK1/2, dually phosphorylated ERK1/2 and ERK1/2 relative activity of the human high-metastatic large cell lung cancer cell lines, L9981 (parent cell line with nm23-H1 gene hetero-deletion), L9981-nm23-H1 (transfected with nm23-H1 gene ) and L9981-PLXSN (transfected with vector) were detected by Western blot and immunoprecipitation technique after treating with U0126 (40μmol/L for 20 minutes).
  • The in vitro proliferative and invasive abilities among the above three lung cancer cell lines were determined by MTT and improved Boyden chamber methods.
  • RESULTS: The phosphorylated ERK1/2 expression level and relative activity in L9981-nm23-H1 lung cancer cell line were remarkably lower than those in L9981 and L9981-PLXSN lung cancer cell lines after being treated with U0126 (P < 0.01), but there was no significant difference between L9981 and L9981-PLXSN lung cancer cell lines.
  • No significant difference of total ERK1/2 expression level was observed among the three lung cancer cell lines (P > 0.05) after being treated with U0126.
  • The in vitro proliferation and invasion of L9981-nm-23H1 lung cancer cell line were remarkably lower than those of L9981 and L9981-PLXSN lung cancer cell lines (P < 0.01 ), but no significant difference was found between L9981 and L9981-PLXSN lung cancer cell lines (P > 0.05 ); U0126 could significantly down-regulate the in vitro proliferation and invasion of L9981 lung cancer cell line (P < 0.01).
  • CONCLUSIONS: Blocking the activity of ERK1/2 in L9981 lung cancer cell line and transfecting the nm23-H1 gene into the L9981 lung cancer cell line may produce similar cell biological behavior changes, namely the significant reduction of in vitro proliferation and invasion of L9981 lung cancer cell line.
  • These results indicate that the molecular mechanism which nm23-H1 gene reverses invasion and proliferation of the human high-metastatic large cell lung cancer cell line may be related to its effects of down-regulating the activity of the key kinase ERK1/2 of Ras-to-MAPK signal transduction pathway.

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  • (PMID = 21176443.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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62. Gao LW, Zhu W, Feng ZH, An N: [Comparative proteomic analysis of human large cell lung cancer cell line with high and low metastasis potentials]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2008 Sep;39(5):706-10
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  • [Title] [Comparative proteomic analysis of human large cell lung cancer cell line with high and low metastasis potentials].
  • OBJECTIVE: A comparative proteomic analysis on two human large cell lung cancer strains with high metastasis potential (L9981) and low metastasis potential (NL9980) were conducted.
  • METHODS: The total proteins of the two cell lines were separated by immobilized pH gradient (IPG )-based two-dimensional gel electrophoresis.
  • The differential expression proteins of the two cell lines were analyzed using image analysis software.
  • MS and biological informatics study found that the expressions of heat shock 70 kD protein 9B precursor, MTHSP75 and glutathione synthetas incerased in L9981 cells.
  • However, a variant of P47 protein, immunoglobulin heavy chain variable region, enolasel, heat shock protein and eukaryotic translation initiation fact 3 were down-regulated in L9981 cells.
  • Pyruvate kinase (PK) was only expressed in L9981 cells while WD-40 repeat protein was only expressed in NL9980 cells.
  • CONCLUSIONS: The metastatic lung cancer cell lines display different protein profiles compared to the non metastatic lung cancer cell lines.
  • The identified proteins are likely to be associated with tumor metastasis, 4hich could serve as a basis for searching potential prognosis markers of lung cancer and elucidating the mechanisms of the metastasis of lung cancer.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Lung Neoplasms / pathology. Neoplasm Metastasis / pathology. Proteomics / methods
  • [MeSH-minor] Humans. Tumor Cells, Cultured

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  • (PMID = 19024295.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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63. Li Y, Zhou Q, Sun Z, Sun Z, Wang Y, Qin Y, Zhu W, Chen X: [Effects of targeting inhibition of ERK1/2 signal transduction pathway on malignant biological behaviors of human high-metastatic large cell lung cancer cell line L9981]. Zhongguo Fei Ai Za Zhi; 2005 Dec 20;8(6):504-9
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  • [Title] [Effects of targeting inhibition of ERK1/2 signal transduction pathway on malignant biological behaviors of human high-metastatic large cell lung cancer cell line L9981].
  • BACKGROUND: It has been known that oncogenesis and development of lung can- cer is a complex process regulated many genes and involved in multistages.
  • The aim of this study is to investigate the influence of exogenous MEK1/2 pathway inhibitor U0126 on the expression and activity of extracellular signal-regulated kinase (ERK1/2) of human high-metastatic large cell lung cancer cell line L9981 and its malignant biological behaviors.
  • METHODS: The expressive levels of total-ERK1/2, dually phosphorylated ERK1/2 and ERK1/2 relative activity of the human high-metastatic large cell lung cancer cell line L9981 (parent cell line with nm23-H1 gene hetero-deletion ) were detected by Western blot and immuno-precipitation technique after treating with different doses of U0126.
  • The in vitro proliferative and invasive abilities of the lung cancer cell line were determined by MTT and modified Boyden chamber methods.
  • CONCLUSIONS: The inhibition of Ras-to-MAPK pathway by Ras-to-MAPK specific inhibitor U0126 targeting the Ras-to-MAPK pathway of the human high-metastatic large cell lung cancer cell line L9981 is dose-dependent and time-dependent.
  • Suppressing or blocking of Ras-to-MAPK signal transduction pathway can reverse the invasive and metastatic phenotype of the human high-metastatic large cell lung cancer cell line L9981.
  • These results suggest that the key kinase MEK1/2 of the ERK1/2 pathway may be a potent therapeutic target for human lung cancer.


64. Sugaya M, Takenoyama M, Shigematsu Y, Baba T, Fukuyama T, Nagata Y, Mizukami M, So T, Ichiki Y, Yasuda M, So T, Hanagiri T, Sugio K, Yasumoto K: Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung. Int J Cancer; 2007 Mar 1;120(5):1055-62
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  • [Title] Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung.
  • The aim of the present study was to elucidate the tumor-specific cellular immunological responses occurring in a patient with large cell carcinoma of the lung who had no evidence of recurrence following surgical resections of both a primary lung lesion and a metastatic adrenal lesion.
  • The F2b possessed T cell receptor (TCR) using the Valpha5 and Vbeta7 gene segment.
  • The existence of precursor CTL (pCTL) against autologous tumor cells (A904L) was analyzed using CTL clone-specific PCR.
  • The F2b recognized 3 out of 7 HLA-A24 positive allogeneic tumor cell lines and in 1 out of 7 HLA-A24 negative allogeneic tumor cell lines when transfected with HLA-A24.
  • This peptide is therefore considered to be potentially useful for performing specific immunotherapy in a significant proportion of lung cancer patients bearing HLA-A24.
  • [MeSH-major] Antigens, Neoplasm / isolation & purification. Carcinoma, Large Cell / immunology. HLA-A Antigens / analysis. Lung Neoplasms / immunology. Microfilament Proteins / genetics. Oligopeptides / isolation & purification. T-Lymphocytes, Cytotoxic / immunology
  • [MeSH-minor] Alternative Splicing. Amino Acid Sequence. Cytotoxicity, Immunologic / genetics. DNA, Complementary / genetics. Gene Expression. HLA-A24 Antigen. Humans. Molecular Sequence Data. Neoplasm Recurrence, Local / diagnosis. Peptides / genetics. Peptides / immunology. Peptides / isolation & purification. Receptors, Antigen, T-Cell / genetics. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 17131342.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA, Complementary; 0 / HLA-A Antigens; 0 / HLA-A*24:02 antigen; 0 / HLA-A24 Antigen; 0 / Microfilament Proteins; 0 / NYGFQIHTK; 0 / Oligopeptides; 0 / Peptides; 0 / Receptors, Antigen, T-Cell; 0 / TRIOBP protein, human
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65. Hu B, Chen J, Liu H, Wu H, Wu Z, Wang Y, Bai Y, Li Y, Zhou Q: [Genome-wide detection of loss of heterozygosity and copy number variation in a human lung large cell carcinoma cell line by affymetrix single-nucleotide polymorphism array 500K.]. Zhongguo Fei Ai Za Zhi; 2008 Jun 20;11(3):327-32

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  • [Title] [Genome-wide detection of loss of heterozygosity and copy number variation in a human lung large cell carcinoma cell line by affymetrix single-nucleotide polymorphism array 500K.].
  • BACKGROUND: Loss of heterozygosity (LOH) and Copy number copy number variation (CNV) of DNA sequences is a common feature of cancer genomes, which is thought to be linked to tumorigenesis and progression.
  • High-density singlenucleotide polymorphism (SNP) genotyping array are able to provided a genotype and copy number information with genome-wide coverage, which is suitable for the analysis of complex genetic alterations present in cancer.
  • Thus a human lung large cell carcinoma cell line NL9980 was assayed for the global profile of LOH and CNV.
  • METHODS: Genomic DNA from the cell line was screened for LOH and CNV using Affymetrix GeneChip(R) Human Mapping array 500K Set.
  • The hybridization intensity data of 500 000 SNP loci was analyzed using Affymetrix proprietary software for genotyping and copy number of each locus, and a genome-wide map of LOH and CNV of the cell line was constructed.
  • And it is possible to achieve high performance outcomes using Affymetrix SNP array 500K to interrogate LOH and CNV in lung cancer genome.
  • This advance of highresolution with allelic information should substantially improve the ability to further understanding of the genetic basis of lung cancers.

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  • (PMID = 20731928.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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66. Mocini D, Longo R, Colivicchi F, Morabito A, Gasparini G, Santini M: A complete atrioventricular block secondary to myocardial metastases of lung cancer. A case report. Ital Heart J; 2005 Nov;6(11):931-2
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  • [Title] A complete atrioventricular block secondary to myocardial metastases of lung cancer. A case report.
  • The clinical diagnosis is very difficult because there are no early symptoms and most often, the presence of metastases in other sites, such as lung and lymph nodes, may determine a misunderstanding of the clinical picture.
  • We report the case of a young male (44 years old) with a complete atrioventricular block due to metastatic myocardial involvement from a primary occult lung cancer.
  • Autopsy revealed an anaplastic carcinoma of the right lung hilus.
  • [MeSH-major] Carcinoma / secondary. Heart Block / etiology. Heart Neoplasms / secondary. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Echocardiography. Fatal Outcome. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 16320932.001).
  • [ISSN] 1129-471X
  • [Journal-full-title] Italian heart journal : official journal of the Italian Federation of Cardiology
  • [ISO-abbreviation] Ital Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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67. Hasegawa S, Suda T, Negi K, Hattori Y: Lung large cell carcinoma producing granulocyte-colony-stimulating factor. Ann Thorac Surg; 2007 Jan;83(1):308-10
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  • [Title] Lung large cell carcinoma producing granulocyte-colony-stimulating factor.
  • In recent years, tumors producing granulocyte-colony-stimulating factor have been reported in an increasing number of patients, the majority of which have lung cancer.
  • We experience a case of lung carcinoma producing granulocyte-colony-stimulating factor treated by resection and chemotherapy.
  • He remains well 2 years and 10 months after surgery, with no recurrence of the carcinoma.
  • [MeSH-major] Carcinoma, Large Cell / metabolism. Granulocyte Colony-Stimulating Factor / biosynthesis. Lung Neoplasms / metabolism

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  • (PMID = 17184692.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
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68. Pardo J, Martinez-Peñuela AM, Sola JJ, Panizo A, Gúrpide A, Martinez-Peñuela JM, Lozano MD: Large cell carcinoma of the lung: an endangered species? Appl Immunohistochem Mol Morphol; 2009 Oct;17(5):383-92
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  • [Title] Large cell carcinoma of the lung: an endangered species?
  • This study aims to evaluate large cell carcinomas (LCC) of the lung with a panel of immunohistochemical markers in an attempt to identify tumors belonging to other categories.
  • The tumors were 82 (81.3%) classic LCC, 7 (6.9%) neuroendocrine LCC, 6 (5.9%) lymphoepithelioma-like LCC, 3 (2.9%) basaloid LCC, 2 (2%) clear cell LCC, and 1 (1%) LCC with rhabdoid phenotype.
  • Characteristic classic LCC immunophenotype was loss of staining with CK5/6, CK14 positive in most squamous cell carcinoma (SCC), lack of MOC 31 positive in most adenocarcinomas, and positive immunoreactivity to EGFR, PDGFR-alpha and c-kit.
  • 16 (19.5%) of 82 classic LCC correspond to undifferentiated adenosquamous carcinomas, since they displayed conflicting immunostaining for markers of both SCC and adenocarcinomas.
  • The use of 7 immunohistochemical markers, consisting of TTF-1, CK7, CK19, p63, 34betaE12, thrombomodulin, and CD44v6, markedly reduces dramatically to less than 10%, the number of classic LCC by readily identifying cases of poorly differentiated SCCs, adenosquamous carcinoma and adenocarcinomas.

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  • (PMID = 19444077.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal
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69. Buła G, Waler J, Niemiec A, Koziołek H, Bichalski W, Gawrychowski J: Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy. Endokrynol Pol; 2010 Sep-Oct;61(5):427-9
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  • [Title] Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy.
  • They are most often caused by tumours of the kidneys, lungs, mammary glands, ovary, and colon or by melanomas.
  • RESULTS: Among 7 patients with thyroid metastases from renal clear cell carcinoma, as diagnosed postoperatively, cytology of the thyroid material obtained through FNA revealed follicular tumour in 3 (43%) patients, tumour cells in 2 (28.5%) and atypical cells in the other 2 (28.5%).
  • Intraoperative histopathology confirmed the presence of metastasis from renal clear cell carcinoma (1) and indicated thyroid medullary cancer (1), follicular tumour (4), or trabecular adenoma with necrosis (1).
  • Among two patients with thyroid metastases from breast cancer, cytology confirmed a metastasis from breast cancer in one (the woman was disqualified for surgical treatment) and indicated follicular tumour in one.
  • Intraoperative histopathology suggested thyroid anaplastic cancer.
  • Examination of biopsy specimen revealed epithelial cells accompanied by cell atypia in one patient with thyroid metastasis from lung cancer.
  • CONCLUSIONS: Follicular tumour diagnosed by fine needle aspiration biopsy in patients after treatment for other cancers, especially renal clear cell carcinoma, should alert the surgeon to the possibility that it could be a metastasis of this cancer to the thyroid gland.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Adenocarcinoma, Clear Cell / secondary. Adenocarcinoma, Follicular / pathology. Adenocarcinoma, Follicular / secondary. Thyroid Neoplasms / pathology. Thyroid Neoplasms / secondary
  • [MeSH-minor] Adenoma / pathology. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Neuroendocrine. Female. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Middle Aged. Monitoring, Intraoperative / methods

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  • (PMID = 21049452.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Thyroid cancer, medullary
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70. Wang T, Xu J, Zhong NS: [Relationship between the acquired multi-drug resistance of human large cell lung cancer cell line NCI-H460 by cisplatin selection and p53 mutation]. Zhonghua Jie He He Hu Xi Za Zhi; 2005 Feb;28(2):102-7
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  • [Title] [Relationship between the acquired multi-drug resistance of human large cell lung cancer cell line NCI-H460 by cisplatin selection and p53 mutation].
  • OBJECTIVE: To explore the role of p53 mutation in the development of acquired multi-drug resistance during lung cancer chemotherapy.
  • METHODS: A resistance large cell lung carcinoma cell line (H460/DDP) was established by high dose (50 micromol/L) cisplatin intermittent selection from its parental cell NCI-H460 that had wild type p53 (wtp53).
  • Several multi-drug resistant proteins (MRP) including lung relative protein (LRP), P-gp, MRP, glutathione transferase-pi, topoisomerase II and P53 were checked by immunocytochemistry.
  • The H460/DDP cells were transected with plasmid pShuttle-CMV-wtp53 cDNA and measurement of drug sensitivity was performed after transfection.
  • RESULTS: The resistance index to cisplatin and carboplatin in H460/DDP cell line was 10.21 and 9.98 respectively, and the cell line also exhibited cross-resistance to 5-fluorouracil, etoposide, methotrexate, adriamycin, epirubicin, bleomycin and novantrone, except for taxol.
  • H460/DDP cells transfected with plasmid pShuttle-CMV-wtp53 cDNA reversed partly (53.2%) the resistance to cisplatin/carboplatin, compared to the H460/DDP cells transfected with blank vector.
  • CONCLUSIONS: p53 mutation induced by cisplatin/carboplatin might play an important role in the development of acquired multi-drug resistance of lung cancer chemotherapy. wtp53 substitute therapy during chemotherapy may be an effective method to overcome the acquired drug resistance.
  • [MeSH-major] Carcinoma, Large Cell / pathology. Drug Resistance, Neoplasm / genetics. Lung Neoplasms / pathology. Multidrug Resistance-Associated Proteins / biosynthesis. Mutation. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Cell Line, Tumor. Cisplatin. Drug Resistance, Multiple / genetics. Humans. P-Glycoprotein / biosynthesis. Transfection

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  • (PMID = 15854392.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Multidrug Resistance-Associated Proteins; 0 / P-Glycoprotein; 0 / Tumor Suppressor Protein p53; Q20Q21Q62J / Cisplatin
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71. Ye S, Feng Z, Zhu W, Cai C, Li L, Sun L, Wan H, Ma L, Zhou Q: [Construction of the suppression subtractive cDNA libraries of human large cell lung cancer line L9981 before and after transfection with nm23-H1 gene.]. Zhongguo Fei Ai Za Zhi; 2008 Aug 20;11(4):482-8
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  • [Title] [Construction of the suppression subtractive cDNA libraries of human large cell lung cancer line L9981 before and after transfection with nm23-H1 gene.].
  • BACKGROUND: It has been proven that nm23-H1 gene is an important metastaticsuppressed gene of lung cancer.
  • In order to screen the differential expression genes related to nm23-H1 , we constructed the suppression subtractive cDNA libraries of human large cell lung cancer line L9981 transfected and untransfected with nm23-H1 gene by suppression subtractive hybridization (SSH) in this study, which lay a solid foundation for further screening and cloning metastatic-related genes of nm23-H1.
  • METHODS: The forward and reverse suppression subtractive cDNA libraries were constructed in the human large cell lung cancer line L9981 before and after transfection with nm23-H1 gene (L9981 and L9981-nm23-H1) by SSH method.
  • RESULTS: The suppression subtractive cDNA libraries were successfully constructed in the human large cell lung cancer line L9981 transfected and untransfected with nm23-H1 gene (L9981-nm23-H1 and L9981).
  • The forward and reverse suppression subtractive cDNA libraries of human large cell lung cancer line L9981 transfected and untransfected with nm23-H1 gene (L9981-nm23-H1 and L9981) are successfully constructed by SSH and T/A cloning technology.
  • The expression of nm23-H1 gene in the human large cell lung cancer cell lines may affect the differential expression of some metastatic-related genes.

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  • (PMID = 20735954.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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72. Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R: Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol; 2008 Feb;21(2):192-200
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  • The goal of this study is to evaluate the expressions of these markers in thyroid tumors of the full spectrum of differentiation, with special emphasis on anaplastic carcinomas.
  • A total of 94 cases of thyroid neoplasms were studied: 17 papillary carcinomas, 18 follicular adenomas, 16 follicular carcinomas, 7 poorly differentiated carcinomas, 28 anaplastic carcinomas, and 8 medullary carcinomas.
  • The antibodies to Pax8 and TTF-2 were also applied on 147 lung carcinomas as well as a variety of normal tissues and malignant tumors.
  • Pax8 was expressed in 79% of anaplastic carcinomas to a variable extent, whereas TTF-1 and TTF-2 were seen only in 18 and 7% of anaplastic carcinomas, respectively.
  • TTF-2 was negative in all other neoplastic and non-neoplastic tissues including those of the lung.
  • Pax8 was expressed in renal tubules, fallopian tubes, ovarian inclusion cysts, and lymphoid follicles as well as renal carcinoma, nephroblastoma, seminoma, and ovarian carcinoma, but not in normal tissue and carcinomas of the lung.
  • Pax8 is a useful marker for the diagnosis of anaplastic carcinomas, particularly when the differential diagnosis includes pulmonary carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma / metabolism. Adenosine Triphosphatases / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Papillary / metabolism. DNA-Binding Proteins / metabolism. Paired Box Transcription Factors / metabolism. Thyroid Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Calcitonin / metabolism. Carcinoma / diagnosis. Carcinoma / metabolism. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / metabolism. Female. Fluorescent Antibody Technique, Indirect. Humans. Hyperplasia. Immunoenzyme Techniques. Male. Middle Aged. Thyroid Gland / metabolism. Thyroid Gland / pathology. Tissue Array Analysis

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  • (PMID = 18084247.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / PAX8 protein, human; 0 / Paired Box Transcription Factors; 0 / Transcription Factors; 9007-12-9 / Calcitonin; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / TTF2 protein, human
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73. Che GW, Zhou QH, Zhu W, Wang YP, Qin Y, Liu LX, Chen XH, Sun YL, Sun ZF: [Molecular mechanism of reversing metastatic phenotype in human high-metastatic large cell lung cancer cell line L9981 by nm23-H1]. Ai Zheng; 2005 Mar;24(3):278-84
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  • [Title] [Molecular mechanism of reversing metastatic phenotype in human high-metastatic large cell lung cancer cell line L9981 by nm23-H1].
  • But the molecular mechanism of nm23-H1 in inhibiting or reversing metastasis of lung cancer is unclear.
  • This study was to explore the molecular mechanism of nm23-H1 in reversing metastasis phenotype of lung cancer.
  • METHODS: nm23-H1 gene and pLXSN were separately transfected into human lung cancer cell line L9981.
  • Proliferation of L9981, L9981-pLXSN, and L9981-nm23-H1 cells was detected by MTT assay, cell invasive ability was detected by modified Boyden chamber.
  • Tumorigenesis and experimental lung metastasis were determined in vivo. mRNA and protein levels of beta-catenin, E-Cadherin, CD44S, CD44V6, matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase-1 (TIMP-1), and vascular endothelial growth factor (VEGF) were detected by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot.
  • RESULTS: (1)Cell proliferation, clone formation, and invasive ability were significantly lower in L9981-nm23-H1 cells than in L9981 cells [(19.5+/-2.9)% vs. 100%, 10.3+/-0.7 vs. 21.7+/-1.3, 31.0+/-3.0 vs. 151.0+/-6.3, P<0.01]. (2) The inhibitory rate of tumorigenesis of nude mice was significantly higher in L8891-nm23-H1 group than in L9981 group (85.6% vs. 0%, P<0.001)u the lung metastatic rate was significantly lower in L9981-nm23-H1 group than in L9981 group (0% vs. 100%, P<0.001). (3)nm23-H1 up-regulated mRNA and protein levels of beta-catenin, E-Cadherin, and TIMP-1, and down-regulated levels of MMP-2, CD44V6, and VEGF (P<0.01). (4) nm23-H1 up-regulated mRNA level of CD44s, protein level of CD44s didn't change (P>0.05).
  • CONCLUSION: nm23-H1 gene can reverse malignant and metastatic phenotype of L9981 cells through regulating the expressions of lung cancer metastasis-related genes.
  • [MeSH-major] Carcinoma, Large Cell / secondary. Lung Neoplasms / pathology. Neoplasm Metastasis. Nucleoside-Diphosphate Kinase / biosynthesis
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Proliferation. Gene Expression Regulation, Neoplastic. Humans. Male. Mice. Mice, Inbred BALB C. Mice, Nude. NM23 Nucleoside Diphosphate Kinases. Neoplasm Invasiveness. Neoplasm Transplantation. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Transfection

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  • (PMID = 15757527.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / NM23 Nucleoside Diphosphate Kinases; 0 / RNA, Messenger; EC 2.7.4.6 / NME1 protein, human; EC 2.7.4.6 / Nme1 protein, mouse; EC 2.7.4.6 / Nucleoside-Diphosphate Kinase
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74. Hanagiri T, Oka S, Takenaka S, Baba T, Yasuda M, Ono K, So T, Uramoto H, Takenoyama M, Yasumoto K: Results of surgical resection for patients with large cell carcinoma of the lung. Int J Surg; 2010;8(5):391-4
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  • [Title] Results of surgical resection for patients with large cell carcinoma of the lung.
  • PURPOSE: The clinical features of large cell carcinoma (LCC) of the lung have remained unclear due to the low incidence of the disease.
  • SUBJECTS: This study clinicopathologically evaluated 975 patients who had undergone a resection for non-small cell carcinoma between 1994 and 2007.
  • RESULTS: The LCC patients included 49 males and 8 females and included 9 patients with large cell neuroendocrine carcinoma.
  • The mean smoking pack-year index was 49.9 in the patients with LCC, 27.1 in 625 patients with adenocarcinoma, and 52.5 in 266 patients with squamous cell carcinoma, and this was significantly higher in the patients with LCC than in those with adenocarcinoma.
  • The mean tumor diameter was 38 mm for LCC, 28 mm for adenocarcinoma, and 39 mm for squamous cell carcinoma.
  • The post-operative 5-year survival rate was 60.5% for LCC, 64.3% for large cell neuroendocrine carcinoma, 67.0% for adenocarcinoma, and 50.1% for squamous cell carcinoma.
  • CONCLUSION: The tumor diameter was significantly larger for LCC than for adenocarcinoma at the time of diagnosis.
  • The surgical results were similar between LCC and other non-small cell lung carcinomas.
  • [MeSH-major] Carcinoma, Large Cell / surgery. Lung Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Bronchoscopy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Japan / epidemiology. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate / trends. Tomography, X-Ray Computed. Treatment Outcome

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  • [Copyright] Copyright 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20547250.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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75. Lesniak A, Hodge WG: Large cell carcinoma of the lung and squamous cell carcinoma of the oropharynx presenting as uveitis. Ann Ophthalmol (Skokie); 2009;41(1):52-4
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  • [Title] Large cell carcinoma of the lung and squamous cell carcinoma of the oropharynx presenting as uveitis.
  • Ocular manifestations of systemic malignancy may precede the diagnosis of cancer; some intraocular lymphomas can present initially as chronic uveitis.
  • The two cases described were found to have underlying carcinomas of the lung and oropharynx.
  • [MeSH-major] Carcinoma, Large Cell / diagnosis. Carcinoma, Squamous Cell / diagnosis. Lung Neoplasms / diagnosis. Oropharyngeal Neoplasms / diagnosis. Uveitis / diagnosis

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  • (PMID = 19413230.001).
  • [ISSN] 1530-4086
  • [Journal-full-title] Annals of ophthalmology (Skokie, Ill.)
  • [ISO-abbreviation] Ann Ophthalmol (Skokie)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Zhu W, Deng Y, Zhou Q, Chen X, Wang Y, Liu L, Che G: [Analysis of two-dimension gel electrophoresis of human large cell lung cancer cell lines with different metastasis potentials]. Zhongguo Fei Ai Za Zhi; 2005 Feb 20;8(1):1-7

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  • [Title] [Analysis of two-dimension gel electrophoresis of human large cell lung cancer cell lines with different metastasis potentials].
  • BACKGROUND: Metastasis is not only the malignant characteristics of lung can- cer, but also the chief cause of failure to cure and high mortality of lung cancer.
  • To better explore and understand the mechanism of lung cancer metastasis and to search for potential markers for early diagnosing and reversing lung cancer metastasis, differential proteomic analysis is conducted in two human large cell lung cancer cell lines with high metastasis potentials (L9981) and low metastasis potentials (NL9980) by two-dimension gel electrophoresis (2-DE).
  • METHODS: The total proteins of the two cell lines were separated by immobilized pH gradient (IPG)-based 2-DE.
  • The differentially expressed proteins of the two cell lines were analyzed using image analysis software.
  • RESULTS: A high resolution and reproducible 2-DE image was successfully obtained.
  • The average total number of protein spots was 902±169 in L9981 cells and 941±173 in NL9980 cells in three repeated experiments.
  • Image analysis of siliver-stained 2-DE image revealed that 4 protein spots had significant differential expressions in L9981 and NL9980 (student's t-test, P < 0.05).
  • CONCLUSIONS: The results in this study suggest that an obviously differential proteomic expression exists between the human high- and low-metastatic large cell lung cancer cell lines.
  • It will be helpful to further understand the molecular mechanisms of lung cancer invasion and metastasis, and provide new experimental evidence for searching metastatic-related molecule of lung cancer.

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  • (PMID = 21187015.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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77. Gan MF, Lu HS, Zhang JW, Yu XR: [Interdigitating dendritic cell sarcoma/tumor: a study of 3 cases]. Zhonghua Bing Li Xue Za Zhi; 2008 Oct;37(10):676-9

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  • [Title] [Interdigitating dendritic cell sarcoma/tumor: a study of 3 cases].
  • OBJECTIVE: To study the pathologic features, diagnosis and differential diagnosis of interdigitating dendritic cell sarcoma (IDCS).
  • The site of occurrence included lung, spleen (with lymph node metastasis) and lymph node.
  • Histologically, the tumor cells were arranged in nests, fascicles and whorls, with intimate admixture of many lymphocytes and plasma cells.
  • They were oval to spindle in shape and contained pale eosinophilic cytoplasm, oval and sometimes grooved nuclei, small distinct nucleoli and ill-defined cell borders.
  • Immunohistochemical study showed that the tumor cells expressed S-100 protein.
  • CONCLUSIONS: IDCS is a rare type of histiocytic and dendritic cell malignancy with distinctive morphologic findings.
  • It needs to be distinguished from follicular dendritic cell sarcoma, inflammatory pseudotumor, Langerhans' cell histiocytosis, malignant melanoma, undifferentiated carcinoma and anaplastic large cell lymphoma.
  • Immunohistochemical staining for S-100 protein is helpful in confirming the diagnosis.
  • [MeSH-major] Dendritic Cell Sarcoma, Follicular / pathology. Dendritic Cell Sarcoma, Interdigitating / pathology. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. S100 Proteins / immunology
  • [MeSH-minor] Adolescent. Carcinoma / pathology. Dendritic Cells / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 19094486.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S100 Proteins
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78. den Bakker MA, Willemsen S, Grünberg K, Noorduijn LA, van Oosterhout MF, van Suylen RJ, Timens W, Vrugt B, Wiersma-van Tilburg A, Thunnissen FB: Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability. Histopathology; 2010 Feb;56(3):356-63
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  • [Title] Small cell carcinoma of the lung and large cell neuroendocrine carcinoma interobserver variability.
  • AIMS: To test the hypothesis that the published morphological criteria permit reliable segregation of small cell carcinoma of the lung (SCLC) and large cell neuroendocrine carcinoma (LCNEC) cases by determining the interobserver variation.
  • METHODS AND RESULTS: One hundred and seventy cases of SCLC, LCNEC and cases diagnosed as neuroendocrine lung carcinoma before LCNEC had been established as a diagnostic category were retrieved from the archives of the assessor's institutes.
  • Unanimity of diagnosis was achieved for only 20 cases; a majority diagnosis was reached for 115 cases.
  • In 35 cases no consensus diagnosis could be reached.
  • [MeSH-major] Carcinoma, Large Cell / epidemiology. Carcinoma, Neuroendocrine / epidemiology. Lung Neoplasms / epidemiology. Small Cell Lung Carcinoma / epidemiology

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  • (PMID = 20459535.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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79. Ohashi K, Kiura K, Takigawa N, Mizushima T, Ino H, Tabata M, Ueoka H, Tanimoto M: Successful treatment of a patient with gastric and duodenal metastases from large cell carcinoma of the lung with carboplatin and gemcitabine. Anticancer Res; 2006 Nov-Dec;26(6C):4695-6
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  • [Title] Successful treatment of a patient with gastric and duodenal metastases from large cell carcinoma of the lung with carboplatin and gemcitabine.
  • A 62-year-old man with large cell carcinoma of the lung underwent a right upper lobectomy and four months later demonstrated a relapse in the stomach and duodenum.
  • Although the prognosis for patients with gastrointestinal metastases from lung cancer tends to be extremely poor, treatment with chemotherapy and a metastasectomy have resulted in this patient, achieving a long survival.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Large Cell / drug therapy. Duodenal Neoplasms / drug therapy. Lung Neoplasms / pathology. Stomach Neoplasms / drug therapy

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  • (PMID = 17214328.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
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80. Monica V, Ceppi P, Righi L, Tavaglione V, Volante M, Pelosi G, Scagliotti GV, Papotti M: Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung. Mod Pathol; 2009 May;22(5):709-17
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  • [Title] Desmocollin-3: a new marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung.
  • Lung cancer classification in small-cell and non-small-cell types was recently challenged by data on the differential efficacy of new cytotoxic agents in specific histotypes.
  • An accurate histotype definition has therefore gained interest in both preoperative and surgical materials, but is a hard task especially in undifferentiated large-cell tumors lacking morphological signs of squamous or glandular differentiation.
  • On the basis of gene expression profiling data, reporting a remarkable differential expression of desmocollin-3 (a protein localized in desmosomal junctions of stratified epithelial) between adeno- and squamous cancers, we immunostained 62 cases of resected undifferentiated large-cell lung carcinomas for desmocollin-3 (and for TTF-1, p63 and mucin stain), to test its ability to identify a (residual) squamous phenotype, if present.
  • Desmocollin-3 was expressed in almost half of the undifferentiated large-cell cancers and was mutually exclusive with TTF-1 (positive in 39%; the remaining 18 % of cases was double negative).
  • Special large-cell carcinoma variants expressed desmocollin-3 in 6 of 6 basaloid, 7 of 12 clear-cell types, again mutually exclusive with TTF-1 expression.
  • In 31 cytological samples diagnosed as 'non-small-cell lung carcinoma', desmocollin-3 was again mutually exclusive with TTF-1 and stained all squamous carcinomas, 1 of 19 adenocarcinoma only, and 50% of large-cell carcinoma (all histologically confirmed).
  • This combined morphophenotypic approach may represent a valid adjunct (for both surgical and cytological samples) in the selection of patients with lung cancer to medical treatments tailored according to different efficacy in different lung carcinomas of the squamous, adeno- and large-cell types.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Large Cell / pathology. Carcinoma, Squamous Cell / pathology. Desmocollins / biosynthesis. Lung Neoplasms / pathology

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  • (PMID = 19287461.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / DSC3 protein, human; 0 / Desmocollins; 0 / TTF1 protein, human
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81. Sugimoto S, Doihara H, Ogasawara Y, Aoe M, Sano S, Shimizu N: Intraatrial extension of thyroid cancer: a case report. Acta Med Okayama; 2006 Apr;60(2):135-40
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  • [Title] Intraatrial extension of thyroid cancer: a case report.
  • A 61-year-old man, who was diagnosed with superior vena cava syndrome by papillary thyroid carcinoma, was referred to our hospital.
  • Extended resection of thyroid cancer was performed with cardiopulmonary bypass.
  • A histological diagnosis of anaplastic carcinoma arising from transformation of papillary carcinoma was made.
  • After the operation, bilateral ureteral occlusion by peritoneal dissemination and multiple lung metastases were detected.
  • Intraatrial extension of thyroid cancer is rare, and only 12 cases have been reported in the literature.
  • We present a case of thyroid cancer with intraatrial extension.
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Cardiopulmonary Bypass. Heart Atria / pathology. Humans. Male. Middle Aged. Syndrome. Tracheal Neoplasms / secondary. Tracheal Neoplasms / surgery. Vascular Neoplasms / secondary. Vascular Neoplasms / surgery. Vena Cava, Superior / pathology

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  • (PMID = 16680191.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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82. Hornick JL, Dal Cin P, Fletcher CD: Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Am J Surg Pathol; 2009 Apr;33(4):542-50
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  • We evaluated 350 tumors: 136 ES, including 64 conventional ("distal") ES, 64 proximal-type ES, and 8 with hybrid features of conventional and proximal-type ES; 54 metastatic carcinomas (22 from lung, 6 breast, 6 stomach, 5 colorectum, 5 kidney, 5 prostate, 5 pancreas); 12 metastatic testicular embryonal carcinomas; 20 metastatic melanomas; 20 epithelioid mesotheliomas; 20 epithelioid angiosarcomas; 10 epithelioid hemangioendotheliomas; 24 epithelioid malignant peripheral nerve sheath tumors (MPNST); 22 myoepithelial carcinomas of soft tissue; 7 anaplastic large cell lymphomas; 5 histiocytic sarcomas; and 10 control MRT of infancy (4 brain, 3 liver, 2 soft tissue, 1 kidney).
  • Immunostaining for INI1 can be used to confirm the diagnosis of ES in the appropriate context.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Carcinoma, Embryonal / metabolism. Carcinoma, Embryonal / secondary. Female. Humans. Immunohistochemistry / methods. Infant. Male

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  • (PMID = 19033866.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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83. Nakazato Y, Imai K, Abe T, Tamura N, Shimazu K: Unpleasant sweet taste: a symptom of SIADH caused by lung cancer. J Neurol Neurosurg Psychiatry; 2006 Mar;77(3):405-6
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  • [Title] Unpleasant sweet taste: a symptom of SIADH caused by lung cancer.
  • A 56 year old woman with large cell lung carcinoma complained of an unpleasant sweet taste (dysgeusia).
  • [MeSH-major] Carcinoma, Large Cell / diagnosis. Dysgeusia / etiology. Hyponatremia / complications. Inappropriate ADH Syndrome / etiology. Lung Neoplasms / diagnosis. Taste
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Reference Values. Sodium / blood

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  • (PMID = 16484655.001).
  • [ISSN] 0022-3050
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 9NEZ333N27 / Sodium
  • [Other-IDs] NLM/ PMC2077685
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84. Uchida N, Fukino S, Kodama W, Tamai N, Hiroe T, Fukata T: Large-cell carcinoma of the lung with a remarkable preoperative elevation of serum carcinoembryonic antigen level. Gen Thorac Cardiovasc Surg; 2007 May;55(5):217-21
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  • [Title] Large-cell carcinoma of the lung with a remarkable preoperative elevation of serum carcinoembryonic antigen level.
  • Carcinoembryonic antigen, a serum tumor marker, is useful for diagnosing cancer and for following the response to therapy in cancer cases.
  • Chest computed tomography revealed a tumor in the posterior segment of the right lung and a swollen right interlobar lymph node.
  • Right lung pneumonectomy and node dissection were performed.
  • A histological diagnosis determined that the tumor was a large-cell carcinoma at clinical stage IIA.
  • Immunohistochemical analysis detected the production of carcinoembryonic antigen by the tumor cells.
  • This is a rare case of lung cancer with no evidence of recurrence and metastasis for 8 years despite markedly elevated preoperative carcinoembryonic antigen levels.
  • [MeSH-major] Carcinoembryonic Antigen / blood. Carcinoma, Large Cell / immunology. Lung Neoplasms / immunology

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  • (PMID = 17554998.001).
  • [ISSN] 1863-6705
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen
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85. Machida Y, Lijima M, Nakamura K, Ota S, Hattori N, Mizuno Y: [A 60-year-old man with intention tremor as an initial symptom followed by cerebellar ataxia, peripheral neuropathy and dementia]. No To Shinkei; 2005 Aug;57(8):710-9
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  • On neurologic examination, he showed Gottron sign and fine crackle in both lungs.
  • An anaplastic carcinoma was found in his jejunum.
  • Other diagnosis entertained included MERRF, GSS, Ramsay Hunt syndrome, subacute combined degeneration, spinocerebellar degeneration.
  • Post-mortem examination revealed poorly differentiated carcinoma in the small intestine.
  • Neuronal cell loss was observed in the Purkinje cell and granular cell layer in the cerebellum.
  • The neuropathologist concluded that neuropathological diagnosis was a spinocerebellar ataxia with neuropathological similarities to Friedreich ataxia.
  • [MeSH-major] Dementia / complications. Dementia / diagnosis. Paraneoplastic Syndromes / complications. Paraneoplastic Syndromes / diagnosis. Spinocerebellar Ataxias / complications. Spinocerebellar Ataxias / diagnosis. Tremor / etiology
  • [MeSH-minor] Aged. Biomarkers / analysis. Brain / pathology. Carcinoma / complications. Carcinoma / diagnosis. Diagnosis, Differential. Fatal Outcome. Humans. Intestinal Neoplasms / complications. Intestinal Neoplasms / diagnosis. Intestine, Small. Lung Diseases, Interstitial / complications. Lung Diseases, Interstitial / diagnosis. Magnetic Resonance Imaging. Male. Muscle, Skeletal / pathology. Receptors, Interleukin-2 / analysis. Tomography, X-Ray Computed

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  • (PMID = 16146216.001).
  • [ISSN] 0006-8969
  • [Journal-full-title] Nō to shinkei = Brain and nerve
  • [ISO-abbreviation] No To Shinkei
  • [Language] jpn
  • [Publication-type] Case Reports; Clinical Conference; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptors, Interleukin-2
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86. Oshita H, Itai J, Omori K, Okamoto N, Awaya Y: [Pulmonary embolism in a patient with large cell lung carcinoma during chemotherapy-case report]. Gan To Kagaku Ryoho; 2009 Jan;36(1):105-7
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  • [Title] [Pulmonary embolism in a patient with large cell lung carcinoma during chemotherapy-case report].
  • The patient, a 64-year-old woman, was diagnosed as having large cell carcinoma(stageIV)eighteen months ago.
  • Thrombosis is a frequent complication in cancer patients and represents an important cause of morbidity and mortality.
  • Great care should be taken for complications of thrombosis in cancer treatment.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Carcinoma, Large Cell / complications. Carcinoma, Large Cell / drug therapy. Lung Neoplasms / complications. Lung Neoplasms / drug therapy. Pulmonary Embolism / complications

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  • (PMID = 19151573.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Antineoplastic Agents
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87. Tambo Y, Kasahara K, Fujimura M, Tamori S, Araya T, Sone T, Nakao S: [A case of advanced large cell lung carcinoma for whom fourth-line chemotherapy of cisplatin and gemcitabine proved effective for the first time]. Gan To Kagaku Ryoho; 2007 Feb;34(2):217-9
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  • [Title] [A case of advanced large cell lung carcinoma for whom fourth-line chemotherapy of cisplatin and gemcitabine proved effective for the first time].
  • Chest X-ray revealed a lung mass shadow in the lower left lung field.
  • We diagnosed it as an advanced large cell carcinoma after conducting transbronchial lung biopsy and neck lymphnode biopsy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Large Cell / drug therapy. Lung Neoplasms / drug therapy. Lymph Nodes / pathology

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  • (PMID = 17301530.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Taxoids; 0W860991D6 / Deoxycytidine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 5V9KLZ54CY / Vinblastine; 5VT6420TIG / Oxonic Acid; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
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88. Liao HT, Chien CH, Chen CH, Wang HP, Huang DF: Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma. Clin Rheumatol; 2007 Jun;26(6):1008-10
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  • [Title] Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma.
  • Autoimmune inner ear disease (AIED) is a very rare disorder with distinct clinical features and can occur in patients with malignancy or autoimmune diseases.
  • During the period of treatment, three episodes of AIED occurred, and eventually, lung cancer developed.
  • From the time relationship and clinical manifestations of neuropathy and livedo reticularis, the first episode of hearing loss was more likely to be related to vasculitis itself, while the third episode may well have been associated with the development of lung cancer given the dramatic improvement in the clinical condition following treatment of the tumor by excision and cancer chemotherapy.
  • [MeSH-major] Autoimmune Diseases / complications. Carcinoma, Large Cell / complications. Carcinoma, Non-Small-Cell Lung / complications. Labyrinth Diseases / immunology. Lung Neoplasms / complications. Polyarteritis Nodosa / complications


89. Ausín P, Gómez-Caro A, Rojo RP, Moradiellos FJ, Díaz-Hellín V, de Nicolás JL: [Spontaneous hemothorax caused by lung cancer]. Arch Bronconeumol; 2005 Jul;41(7):400-1
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  • [Title] [Spontaneous hemothorax caused by lung cancer].
  • [Transliterated title] Hemotórax espontáneo por carcinoma broncogénico.
  • We describe the case of a 26-year-old man with spontaneous hemothorax secondary to large-cell carcinoma of the lung, with liver and bone metastases.
  • [MeSH-major] Carcinoma, Bronchogenic / complications. Hemothorax / etiology. Lung Neoplasms / complications

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  • (PMID = 16029735.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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90. Su CC, Yang JS, Lu CC, Chiang JH, Wu CL, Lin JJ, Lai KC, Hsia TC, Lu HF, Fan MJ, Chung JG: Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. Phytother Res; 2010 Feb;24(2):189-92
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  • [Title] Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model.
  • Curcumin can decrease viable cells through the induction of apoptosis in human lung cancer NCI-H460 cells in vitro.
  • However, there are no reports that curcumin can inhibit cancer cells in vivo.
  • In this study, NCI-H460 lung tumour cells were implanted directly into nude mice and divided randomly into four groups to be treated with vehicle, curcumin (30 mg/kg of body weight), curcumin (45 mg/kg of body weight) and doxorubicin (8 mg/kg of body weight).
  • ), with treatment starting 4 weeks after inoculation with the NCI-H460 cells.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / pharmacology. Carcinoma, Large Cell / drug therapy. Curcumin / pharmacology
  • [MeSH-minor] Animals. Cell Line, Tumor. Doxorubicin / pharmacology. Female. Humans. Mice. Mice, Inbred BALB C. Mice, Nude. Xenograft Model Antitumor Assays

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  • [Copyright] (c) 2010 John Wiley & Sons, Ltd.
  • (PMID = 20077433.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 80168379AG / Doxorubicin; IT942ZTH98 / Curcumin
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91. Al-Brahim N, Ross C, Carter B, Chorneyko K: The value of postmortem examination in cases of metastasis of unknown origin-20-year retrospective data from a tertiary care center. Ann Diagn Pathol; 2005 Apr;9(2):77-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To evaluate the value of autopsy in determining the primary site of MUO, this study reviewed the Hamilton experience-over the last 20 years-with patients autopsied with clinical diagnosis of MUO.
  • Fifty-three cases of MUO were identified (MUO was defined as a patient with pathological and/or radiological diagnosis of a metastatic tumor for which the primary site of malignancy was unknown).
  • Pathological diagnoses at autopsy were adenocarcinoma (n = 37), small cell carcinoma (n = 6), anaplastic carcinoma (n = 3), and undifferentiated carcinoma (n = 3).
  • Primary tumors were identified in 27 patients (51%), most commonly in the lung (n = 8), large bowel (n = 6), and pancreas (n = 4).
  • Histochemical and immunohistochemical stains were helpful in reaching the diagnosis of a primary tumor in 4 of 27 cases.
  • (1) in this series, autopsy was helpful in establishing the diagnosis of a primary tumor in 51% of the cases, reaffirming the value of postmortem examination in these instances;.
  • (3) the lung and the large bowel were the most frequent sites for primary tumors; and (4) careful gross and histological examinations remain the most important tools in identifying the primary site.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Histocytochemistry / methods. Hospitals, University. Humans. Immunohistochemistry / methods. Intestinal Neoplasms / pathology. Intestine, Large. Lung Neoplasms / pathology. Male. Middle Aged. Pancreatic Neoplasms / pathology. Retrospective Studies. Staining and Labeling. Survival Analysis

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  • (PMID = 15806513.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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92. Tundis R, Deguin B, Loizzo MR, Bonesi M, Statti GA, Tillequin F, Menichini F: Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. Bioorg Med Chem Lett; 2005 Nov 1;15(21):4757-60

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  • The antiproliferative activity of several flavonoids isolated from Linaria reflexa Desf. (Scrophulariaceae) was evaluated in vitro by the SRB assay against the large cell lung carcinoma cell line COR-L23, hepatocellular carcinoma cell line HepG-2, renal adenocarcinoma cell line ACHN, amelanotic melanoma cell line C32, colorectal adenocarcinoma cell line Caco-2, and normal human fetal lung MRC5.
  • Pectolinarin exhibited strong cytotoxic activity on COR-L23, Caco-2, and C32 cell lines with an IC50 of 5.03, 6.18, and 7.17 microM.
  • [MeSH-minor] Acetylation. Cell Line, Tumor. Cell Proliferation / drug effects. Chromones / chemistry. Chromones / pharmacology. Drug Screening Assays, Antitumor. Humans. Hydrolysis. Inhibitory Concentration 50. Structure-Activity Relationship

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  • (PMID = 16125932.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Chromones; 0 / Flavones; 28978-02-1 / pectolinarin
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93. Nogales FF, Buriticá C, Regauer S, González T: Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors. Am J Surg Pathol; 2005 Sep;29(9):1247-51
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  • The tumor in the second case consisted of an AFP-positive glandular YST, with a glandulopapillary pattern closely resembling fetal lung type adenocarcinoma, coexisting with an AFP-negative, cytokeratin 20-positive, atypical MC; transitional areas between the two components were also seen.
  • AFP levels became negative during the course of disease paralleling the disappearance of the YST component and the overgrowth of an increasingly anaplastic MC.
  • The patient died 1 year after diagnosis.
  • It is important to differentiate the yolk sac and carcinoid components due to their different responses to chemotherapy and to evaluate the possibility of mucinous carcinoid developing into a highly aggressive carcinoma.

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  • (PMID = 16096416.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / alpha-Fetoproteins
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94. Baloch ZW, LiVolsi VA: Unusual tumors of the thyroid gland. Endocrinol Metab Clin North Am; 2008 Jun;37(2):297-310, vii
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  • Most primary epithelial tumors of thyroid are derived from follicular cells.
  • These include follicular adenoma and carcinoma (Hürthle and non-Hürthle), and papillary carcinoma and its variants.
  • Other primary epithelial tumors include medullary carcinoma, mixed medullary and follicular carcinomas, insular and poorly differentiated carcinoma, anaplastic carcinoma, and the least common squamous carcinoma and related tumors.
  • The secondary tumors represent metastatic tumors to the thyroid usually originating in lung, kidney, and breast.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / pathology. Rare Diseases / diagnosis. Rare Diseases / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Disease Progression. Humans. Neoplasm Staging. Prognosis. Thyroid Gland / pathology

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  • (PMID = 18502328.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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95. Shor S, Helfand SC, Gorman E, Löhr CV: Diagnostic exercise: epithelioid hemangiosarcoma mimicking metastatic prostatic neoplasia in a dog. Vet Pathol; 2009 May;46(3):548-52
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  • Cytologic evaluation of fine needle aspirates from the prostate, testis, and kidney comprised large, clustered or individualized, anaplastic cells that lacked convincing tissue differentiation.
  • Necropsy examination revealed an irregularly enlarged prostate with dark tan to red zones and multiple, discrete, beige to dark red nodules that ranged from 0.5 to 6 cm in diameter in the lung, liver, left kidney, right testis, colon wall, stomach wall, and brain.
  • On histologic examination, discrete nests of anaplastic carcinoma-like tumor cells were found in sections of all affected organs.
  • Results of immunohistochemical examination revealed widespread expression of von Willebrand factor and the absence of cytokeratin in neoplastic cells.
  • The diagnosis was metastatic epithelioid hemangiosarcoma, primary site unknown.

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  • (PMID = 19176508.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Kim SK, Kim DL, Han HS, Kim WS, Kim SJ, Moon WJ, Oh SY, Hwang TS: Pyrosequencing analysis for detection of a BRAFV600E mutation in an FNAB specimen of thyroid nodules. Diagn Mol Pathol; 2008 Jun;17(2):118-25
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  • However, 10% to 30% of cases with indeterminate cytology in FNAB need other diagnostic tools to refine diagnosis.
  • METHODS: A total of 103 surgically confirmed patients' FNA slides were recruited and DNA was extracted after atypical cells were scraped from the slides.
  • In detail, 63 (84.0%) of 75 papillary thyroid carcinoma (PTC) samples showed positive BRAF mutation, whereas 3 follicular thyroid carcinomas, 1 anaplastic carcinoma, 1 medullary thyroid carcinoma, and 1 metastatic lung carcinoma did not show BRAF mutation.
  • [MeSH-minor] Biopsy, Fine-Needle. Cell Line, Tumor. DNA, Neoplasm / analysis. Humans. Polymerase Chain Reaction. Predictive Value of Tests


97. Nauck MA, Reinecke M, Perren A, Frystyk J, Berishvili G, Zwimpfer C, Figge AM, Flyvbjerg A, Lankisch PG, Blum WF, Klöppel G, Schmiegel W, Zapf J: Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung. J Clin Endocrinol Metab; 2007 May;92(5):1600-5
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  • [Title] Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung.
  • CONTEXT: Nonpancreatic tumors may cause recurrent hypoglycemia known as nonislet cell tumor hypoglycemia.
  • Multiple small lung nodules were detected by computed tomography scan.
  • An undifferentiated large-cell carcinoma was diagnosed from an axillary lymph node metastasis.
  • After chemotherapy with carboplatinum/etoposide, the lung nodules largely regressed, and serum IGF-I and the IGF-I content of the two binding protein complexes became normal.
  • [MeSH-major] Carcinoma, Large Cell / metabolism. Hypoglycemia / etiology. Insulin-Like Growth Factor I / biosynthesis. Lung Neoplasms / metabolism. Paraneoplastic Endocrine Syndromes / metabolism

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  • [CommentIn] J Clin Endocrinol Metab. 2007 May;92(5):1616 [17483375.001]
  • (PMID = 17299065.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Blood Glucose; 0 / Insulin; 0 / Insulin-Like Growth Factor Binding Proteins; 12629-01-5 / Human Growth Hormone; 63231-63-0 / RNA; 67763-96-6 / Insulin-Like Growth Factor I; 67763-97-7 / Insulin-Like Growth Factor II; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
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98. Cai CJ, Ye SJ, Zhu W, Sun LY, Wan HS, Feng ZH, Ma L, Li L: [Study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2010 Nov;41(6):941-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene].
  • OBJECTIVE: To study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene.
  • After microarray hybridization, clones sequencing, sequence homology search, the information of differently expressed genes in human large cell lung cancer cell line of L9981 and L9981-nm23-H1 were obtained and then further confirmed by real-time quantitative PCR.
  • RESULTS: Gene expression profiling chips of differently expressed genes in human large cell lung cancer cell line L9981 and L9981-nm23-H1 were successfully constructed.
  • After real-time quantitative PCR evaluation, we found that the mRNA of 8 genes including PSMA7, SBDS, ODC1, YARS, CSDA, PTP4A1, SHPRH and TOMM7 was up-regulated in the cell line of L9981 after transfected with NM23-H1 gene, whereas the mRNA of PKM2 and GMNN was down-regulated.
  • CONCLUSION: NM23-H1 gene may be the upstream regulator of metastasis-associated genes, which can regulate the downstream genes to achieve a series of lung cancer metastatic potential.
  • [MeSH-major] Lung Neoplasms / genetics. NM23 Nucleoside Diphosphate Kinases / genetics. Transcriptome
  • [MeSH-minor] Cell Line, Tumor. Gene Expression Regulation, Neoplastic. Humans. Neoplasm Invasiveness. Neoplasm Metastasis


99. Gilbert JA, Frederick LM, Pobst LJ, Ames MM: Hydrogen peroxide degradation and selective carbidopa-induced cytotoxicity against human tumor lines. Biochem Pharmacol; 2005 Apr 15;69(8):1159-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The carcinoid tumor, an uncommon neuroendocrine neoplasm, is associated with serotonin overproduction as is more common small cell lung carcinoma (SCLC).
  • alpha-Methyl-dopahydrazine (carbidopa), an inhibitor of the serotonin synthetic enzyme aromatic-L-amino acid decarboxylase, proved lethal to NCI-H727 lung carcinoid cells as well as NCI-H146 and NCI-H209 SCLC cells, but not to five other human tumor cell lines of differing origins [Gilbert JA, Frederick LM, Ames MM.
  • The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin.
  • Cancer Res. 2000;6:4365-72].
  • Alkaline elution studies revealed carbidopa-dependent single-strand DNA breaks in sensitive carcinoid cells comparable to those induced by similar concentrations of H2O2.
  • Neither compound induced significant DNA damage in carbidopa-resistant NCI-H460 large cell lung carcinoma cells.
  • Furthermore, when carbidopa was incubated with a variety of tumor cell types, not only were decreased media H2O2 concentrations detected in the presence of cells, but cell lines least sensitive to carbidopa degraded exogenous H2O2 more rapidly than did sensitive cells.
  • Implicated in these studies, pyruvate degraded H2O2 in RPMI in a dose- and time-dependent manner and reversed carbidopa-induced cytotoxicity to carcinoid cells.
  • Extracellular pyruvate levels produced per h by resistant large cell lung carcinoma cells averaged four-fold that of sensitive carcinoid cells plated at equal density (24 h time course).
  • Finally, carbidopa exposure (100 microM, 24 h) depleted extracellular pyruvate from sensitive carcinoid cells, but reduced pyruvate levels from resistant NCI-H460 cells less than 17%.
  • [MeSH-major] Aromatic Amino Acid Decarboxylase Inhibitors. Carbidopa / toxicity. Carcinoid Tumor / drug therapy. Carcinoma, Small Cell / drug therapy. Hydrogen Peroxide / metabolism. Lung Neoplasms / drug therapy
  • [MeSH-minor] Cell Survival / drug effects. Culture Media / chemistry. Culture Media / metabolism. Dose-Response Relationship, Drug. Humans. Kinetics. Oxidation-Reduction. Pyruvic Acid / metabolism. Pyruvic Acid / pharmacology. Tumor Cells, Cultured

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  • (PMID = 15794936.001).
  • [ISSN] 0006-2952
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aromatic Amino Acid Decarboxylase Inhibitors; 0 / Culture Media; 8558G7RUTR / Pyruvic Acid; BBX060AN9V / Hydrogen Peroxide; MNX7R8C5VO / Carbidopa
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100. Kong M, Fan J, Dong A, Cheng H, Xu R: Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai); 2010 Nov;42(11):827-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft.
  • Human lung adenocarcinoma A549 cells, human lung squamous cell carcinoma SK-MES-1 cells, and human lung large cell carcinoma H460 cells were cultured and then treated with PPI.
  • Cell proliferation and apoptosis were measured by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay, flow cytometry, western blot analysis, and DNA ladder.
  • Our results showed that PPI significantly inhibited the proliferation of three non-small cell lung cancer (NSCLC) cell lines, with the inhibitory concentrations (IC50) of 1.24, 2.40, and 2.33 μg/ml for A549, H460, and SK-MES-1 cells, respectively.
  • After being treated with 2.5 µg/ml of PPI for 24 h, the apoptotic rate of A549 cells was 39.68%, which was remarkably higher than that of the control.
  • PPI exhibits antitumor ability in NSCLC cells in vitro and in vivo, which might be related to the apoptosis induced by PPI.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Cell Proliferation / drug effects. Diosgenin / analogs & derivatives. Lung Neoplasms / drug therapy. Plant Extracts / pharmacology. Xenograft Model Antitumor Assays
  • [MeSH-minor] Animals. Apoptosis / drug effects. Blotting, Western. Caspase 3 / metabolism. Cell Line, Tumor. Dose-Response Relationship, Drug. Down-Regulation / drug effects. Humans. Inhibitory Concentration 50. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Molecular Structure. Proto-Oncogene Proteins c-bcl-2 / metabolism. Rhizome / chemistry. Time Factors. Tumor Burden / drug effects

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  • (PMID = 20978038.001).
  • [ISSN] 1745-7270
  • [Journal-full-title] Acta biochimica et biophysica Sinica
  • [ISO-abbreviation] Acta Biochim. Biophys. Sin. (Shanghai)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Plant Extracts; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / polyphyllin I; EC 3.4.22.- / Caspase 3; K49P2K8WLX / Diosgenin
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