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1. Hard GC, Howard PC, Kovatch RM, Bucci TJ: Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor. Toxicol Pathol; 2001 May-Jun;29(3):379-86
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  • Inclusion of FB1 at 50 and 80 ppm in the diet induced liver tumors in female mice, and at 50 and 150 ppm induced renal tumors in male rats (22).
  • The renal tubule tumors induced by FB1 were typified by a rare, highly malignant, anaplastic variant capable of growth by infiltration.
  • Anaplastic variants represented 50% of the mid-dose carcinomas and 80% of the high-dose carcinomas.
  • One of the anaplastic carcinomas in a mid-dose male was a true sarcomatoid phenotype not previously recorded in the rodent.
  • [MeSH-major] Adenoma / chemically induced. Carboxylic Acids / toxicity. Carcinogens, Environmental / toxicity. Carcinoma / chemically induced. Fumonisins. Kidney Neoplasms / chemically induced. Kidney Tubules, Proximal / pathology. Mycotoxins / toxicity
  • [MeSH-minor] Animals. Carcinogenicity Tests. Diet. Dose-Response Relationship, Drug. Female. Hyperplasia / chemically induced. Hyperplasia / pathology. Male. Precancerous Conditions / chemically induced. Precancerous Conditions / pathology. Rats. Rats, Inbred F344

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  • (PMID = 11442024.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carboxylic Acids; 0 / Carcinogens, Environmental; 0 / Fumonisins; 0 / Mycotoxins; 3ZZM97XZ32 / fumonisin B1
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2. Wakshlag JJ, McNeill CJ, Antonyak MA, Boehm JE, Fuji R, Balkman CE, Zgola M, Cerione RA, Page RL: Expression and activity of transglutaminase II in spontaneous tumours of dogs and cats. J Comp Pathol; 2006 Feb-Apr;134(2-3):202-10
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  • Bladder, liver and adrenal gland exhibited prominent expression of TGase II while other tissues, including mammary gland, displayed limited expression and activity.
  • The pattern of expression was not related to the classification of mammary carcinoma (solid, tubulopapillary, complex or anaplastic), except that two anaplastic canine mammary carcinomas showed prominent TGase II expression.
  • Two canine mammary carcinoma cell lines showed prominent TGase expression, and when the TGase activity was inhibited, the cells became more sensitive to doxorubicin-induced cell death.
  • The pro-survival effect of TGase II in canine mammary carcinoma cell lines was similar to that previously reported in humans patients.
  • [MeSH-major] Carcinoma / veterinary. GTP-Binding Proteins / metabolism. Mammary Glands, Animal / enzymology. Mammary Neoplasms, Animal / enzymology. Transglutaminases / metabolism
  • [MeSH-minor] Animals. Antineoplastic Agents / pharmacology. Blotting, Western / veterinary. Cats. Cell Line, Tumor. Cell Survival / drug effects. Dogs. Doxorubicin / pharmacology. Drug Screening Assays, Antitumor / veterinary. Female. Fluorescent Antibody Technique, Indirect / veterinary. Hyperplasia / enzymology. Hyperplasia / pathology. Hyperplasia / veterinary. Retrospective Studies

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  • (PMID = 16615935.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM61762
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; EC 2.3.2.- / transglutaminase 2; EC 2.3.2.13 / Transglutaminases; EC 3.6.1.- / GTP-Binding Proteins
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3. Haberkorn U, Altmann A, Jiang S, Morr I, Mahmut M, Eisenhut M: Iodide uptake in human anaplastic thyroid carcinoma cells after transfer of the human thyroid peroxidase gene. Eur J Nucl Med; 2001 May;28(5):633-8
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  • [Title] Iodide uptake in human anaplastic thyroid carcinoma cells after transfer of the human thyroid peroxidase gene.
  • Poorly differentiated and anaplastic thyroid tumours which lack thyroid-specific gene expression fail to accumulate iodide and, therefore, do not respond to iodine-131 therapy.
  • The human anaplastic thyroid carcinoma cell lines C643 and SW1736, the rat Morris hepatoma cell line MH3924A and the rat papillary thyroid carcinoma cell line L2 were used as in vitro model systems.
  • Genetically modified cell lines expressed up to 1,800 times more hTPO as compared to wild type tumour cells.
  • Future studies will have to concentrate on the possible expression of enzymatically active proteins or the transfer of multiple genes involved in iodide trapping.
  • [MeSH-major] Carcinoma / metabolism. Iodide Peroxidase / genetics. Iodine / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Animals. Drug Resistance / genetics. Genetic Vectors. Humans. Iodine Radioisotopes / therapeutic use. Liver Neoplasms, Experimental / metabolism. Neomycin / pharmacology. Rats. Retroviridae. Thyroglobulin / metabolism. Transfection. Tumor Cells, Cultured / drug effects. Tumor Cells, Cultured / metabolism

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  • (PMID = 11383870.001).
  • [ISSN] 0340-6997
  • [Journal-full-title] European journal of nuclear medicine
  • [ISO-abbreviation] Eur J Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 1404-04-2 / Neomycin; 9010-34-8 / Thyroglobulin; 9679TC07X4 / Iodine; EC 1.11.1.8 / Iodide Peroxidase
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4. Wang CH, Shen YC, Hsieh JJ, Yeh KY, Chang JW: Clodronate alleviates cachexia and prolongs survival in nude mice xenografted with an anaplastic thyroid carcinoma cell line. J Endocrinol; 2006 Aug;190(2):415-23
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  • [Title] Clodronate alleviates cachexia and prolongs survival in nude mice xenografted with an anaplastic thyroid carcinoma cell line.
  • Cancer cachexia is one of the most common manifestations of advanced malignant disease and is frequently associated with decreased survival.
  • Previously, we reported the establishment of a new anaplastic thyroid carcinoma cell line, Thena, and its mouse xenograft, Thena-Nu, which induced cachexia in athymic nude mice.
  • Liver necrosis, observed in tumor-bearing mice, was also improved following clodronate treatment.
  • [MeSH-major] Cachexia / drug therapy. Carcinoma / drug therapy. Clodronic Acid / therapeutic use. Diphosphonates / therapeutic use. Thyroid Neoplasms / drug therapy
  • [MeSH-minor] Animals. Apoptosis. Cell Line, Tumor. Cell Proliferation / drug effects. Enzyme-Linked Immunosorbent Assay / methods. Granulocyte Colony-Stimulating Factor / analysis. Interleukin-6 / analysis. Leukemia Inhibitory Factor. Liver / pathology. Mice. Mice, Inbred BALB C. Mice, Nude. Necrosis. Neoplasm Transplantation. Transplantation, Heterologous. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 16899574.001).
  • [ISSN] 0022-0795
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Interleukin-6; 0 / Leukemia Inhibitory Factor; 0 / Lif protein, mouse; 0 / Tumor Necrosis Factor-alpha; 0813BZ6866 / Clodronic Acid; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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5. Kissel M, Peschke P, Subr V, Ulbrich K, Strunz AM, K├╝hnlein R, Debus J, Friedrich E: Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA. Eur J Nucl Med Mol Imaging; 2002 Aug;29(8):1055-62
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  • [Title] Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA.
  • Synthetic macromolecules such as copolymers of N-(2-hydroxypropyl)methacrylamide (pHPMA) are potential carriers for the delivery of drugs owing to their ability to passively accumulate in solid tumours [enhanced permeation and retention (EPR) effect].
  • While biotin-pHPMA could be detected intracytoplasmically in liver and spleen, a predominantly interstitial localisation was observed within the anaplastic prostate carcinoma (Dunning R3327-AT1).
  • [MeSH-major] Biotin / pharmacokinetics. Drug Carriers / pharmacokinetics. Esters / pharmacokinetics. Iodine Radioisotopes / pharmacokinetics. Methacrylates / pharmacokinetics. Prostatic Neoplasms / metabolism
  • [MeSH-minor] Acrylamides / pharmacokinetics. Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / radionuclide imaging. Animals. Macromolecular Substances. Male. Neoplasm Transplantation. Radiopharmaceuticals / pharmacokinetics. Rats. Reference Values. Solubility. Thigh / pathology. Thigh / radionuclide imaging. Tissue Distribution. Tumor Cells, Cultured. Whole-Body Counting

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  • (PMID = 12173020.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Acrylamides; 0 / Drug Carriers; 0 / Esters; 0 / Iodine Radioisotopes; 0 / Macromolecular Substances; 0 / Methacrylates; 0 / Radiopharmaceuticals; 0 / methacryloylglycylglycine-4-nitrophenyl ester; 21442-01-3 / N-(2-hydroxypropyl)methacrylamide; 6SO6U10H04 / Biotin
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6. Zhou JM, Zhu XF, Liu ZC, Fu LW, Yang XP, Liang YJ, Pan QC: [Antitumor and anti-angiogenic effects of manumycin on human hepatocellular carcinoma HepG2 xenografts in nude mice]. Ai Zheng; 2005 Aug;24(8):935-9
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  • [Title] [Antitumor and anti-angiogenic effects of manumycin on human hepatocellular carcinoma HepG2 xenografts in nude mice].
  • BACKGROUND & OBJECTIVE: Farnesyl-transferase inhibitor manumycin has in vitro and in vivo antitumor effects on pancreatic cancer, colon cancer, and anaplastic thyroid carcinoma.
  • Our previous experiments showed that manumycin could inhibit proliferation pathway and survival pathway in human hepatocellular carcinoma HepG2 cells in vitro.
  • CONCLUSIONS: Manumycin could inhibit the growth of human hepatocellular carcinoma HepG2 xenografts in nude mice.
  • [MeSH-major] Angiogenesis Inhibitors / pharmacology. Antineoplastic Agents / pharmacology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Polyenes / pharmacology. Polyunsaturated Alkamides / pharmacology
  • [MeSH-minor] Animals. Cell Line, Tumor. Dose-Response Relationship, Drug. Female. Fibroblast Growth Factor 2 / metabolism. Humans. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Microcirculation / drug effects. Neoplasm Transplantation. Neovascularization, Pathologic. RNA, Messenger / biosynthesis. RNA, Messenger / genetics. Random Allocation. Vascular Endothelial Growth Factor A / biosynthesis. Vascular Endothelial Growth Factor A / genetics

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  • (PMID = 16086869.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Polyenes; 0 / Polyunsaturated Alkamides; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2; 52665-74-4 / manumycin
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7. Nahari D, Satchi-Fainaro R, Chen M, Mitchell I, Task LB, Liu Z, Kihneman J, Carroll AB, Terada LS, Nwariaku FE: Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer. Mol Cancer Ther; 2007 Apr;6(4):1329-37
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  • [Title] Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer.
  • Anaplastic thyroid carcinoma is an aggressive form of cancer with no treatment.
  • Our goals were to determine the effect of TNP-470 on anaplastic thyroid cancer using an orthotopic murine model, to identify the molecular pathways of TNP-470 actions on endothelial cells, and to determine the non-endothelial tumor effects of TNP-470.
  • We injected human anaplastic thyroid carcinoma cells (DRO'90) into the thyroid glands of nude mice.
  • TNP-470 prolonged survival and reduced liver metastases.
  • TNP-470 had direct cytotoxic effects on anaplastic thyroid carcinoma cells in vitro and in vivo.

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  • (PMID = 17431111.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL061897; United States / NHLBI NIH HHS / HL / R01 HL067256; United States / NIGMS NIH HHS / GM / R01 GM067674-01A1; United States / NHLBI NIH HHS / HL / R01-HL61897; United States / NHLBI NIH HHS / HL / R01-HL67256; United States / NIGMS NIH HHS / GM / R01 GM067674
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Cyclohexanes; 0 / Sesquiterpenes; 0 / Vascular Endothelial Growth Factor A; 129298-91-5 / O-(chloroacetylcarbamoyl)fumagillol; EC 3.6.5.2 / rac GTP-Binding Proteins
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8. Tsujie M, Nakamori S, Nakazuru S, Hayashi N, Okami J, Nagano H, Dono K, Umeshita K, Sakon M, Monden M: [A case of liver metastasis of pancreatic duct carcinoma successfully treated with gemcitabine]. Gan To Kagaku Ryoho; 2003 Feb;30(2):297-301
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  • [Title] [A case of liver metastasis of pancreatic duct carcinoma successfully treated with gemcitabine].
  • We report a patient in whom systemic chemotherapy using gemcitabine was effective against liver metastases of pancreatic cancer.
  • A 72-year-old woman underwent pancreatoduodenectomy with lymphadenectomy and partial resection of the portal vein following a diagnosis of pancreatic cancer, and her postoperative course was uneventful.
  • The diagnosis was stage III anaplastic ductal carcinoma (t2n1P0H0M0).
  • One year and 3 months after the operation, however, her serum level of carbohydrate antigen 19-9 (CA19-9) was found to be elevated, and CT examination revealed a mass in the liver that was diagnosed as liver that was metastases.
  • The serum CA19-9 level was down from 882 U/ml to normal after 5 courses of chemotherapy and CT examination revealed that liver metastases had completely vanished.
  • The prognosis of liver metastases of pancreatic cancer is quite unfavorable.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Pancreatic Ductal / drug therapy. Carcinoma, Pancreatic Ductal / secondary. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Combined Modality Therapy. Drug Administration Schedule. Female. Humans. Quality of Life

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  • (PMID = 12610883.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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9. Baker JL, Aleman M, Madigan J: Intermittent hypoglycemia in a horse with anaplastic carcinoma of the kidney. J Am Vet Med Assoc; 2001 Jan 15;218(2):235-7
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  • [Title] Intermittent hypoglycemia in a horse with anaplastic carcinoma of the kidney.
  • Neoplasia should be considered in the differential diagnosis for adult horses with hypoglycemia.
  • [MeSH-major] Carcinoma / veterinary. Horse Diseases / etiology. Hypoglycemia / veterinary. Kidney Neoplasms / veterinary
  • [MeSH-minor] Abscess / drug therapy. Abscess / veterinary. Animals. Anti-Bacterial Agents / therapeutic use. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Biopsy / veterinary. Blood Glucose / analysis. Clonixin / analogs & derivatives. Clonixin / therapeutic use. Fatal Outcome. Gentamicins / therapeutic use. Horses. Insulin / blood. Liver / ultrasonography. Male

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  • (PMID = 11195830.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Blood Glucose; 0 / Gentamicins; 0 / Insulin; 356IB1O400 / flunixin; V7DXN0M42R / Clonixin
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10. Lin SF, Price DL, Chen CH, Brader P, Li S, Gonzalez L, Zhang Q, Yu YA, Chen N, Szalay AA, Fong Y, Wong RJ: Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo. J Clin Endocrinol Metab; 2008 Nov;93(11):4403-7
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  • [Title] Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo.
  • CONTEXT: Anaplastic thyroid carcinoma (ATC) is a fatal disease with a median survival of only 6 months.
  • We assessed the utility of GLV-1h68 in treating anaplastic thyroid cancer in vivo.
  • At d 10, tumor viral recovery was increased more than 50-fold as compared with the injected dose, and minimal virus was recovered from the lung, liver, brain, heart, spleen, and kidneys.
  • [MeSH-major] Cancer Vaccines / therapeutic use. Carcinoma / immunology. Thyroid Neoplasms / immunology. Vaccinia virus / immunology. Viral Vaccines / therapeutic use
  • [MeSH-minor] Animals. Cell Division / drug effects. Cell Line, Tumor. Genetic Markers. Humans. Mice. Mice, Nude. Neoplasm Transplantation. Transplantation, Heterologous. Viral Plaque Assay

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  • (PMID = 18697871.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA009685
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cancer Vaccines; 0 / Genetic Markers; 0 / Viral Vaccines
  • [Other-IDs] NLM/ PMC3728375
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