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1. Ishiwata I, Ono I, Kiguchi K, Ishiwata C, Soma M, Ishikawa H: Establishment and characterization of a human thyroid carcinoma cell line (HOTHC) producing colony stimulating factor. Hum Cell; 2005 Sep;18(3):163-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishment and characterization of a human thyroid carcinoma cell line (HOTHC) producing colony stimulating factor.
  • A cell line designated HOTHC was established from an anaplastic carcinoma (giant cell type) of the thyroid gland of 80-year-old woman.
  • The HOTHC cells were transplanted into the subcutis of BALB/c nude mice and produced anaplatic carcinomas (giant cell type) resembling the original tumor.

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  • (PMID = 17022149.001).
  • [ISSN] 0914-7470
  • [Journal-full-title] Human cell
  • [ISO-abbreviation] Hum. Cell
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Colony-Stimulating Factors
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2. Roche B, Larroumets G, Dejax C, Kwiatkowsi F, Desbiez F, Thieblot P, Tauveron I: Epidemiology, clinical presentation, treatment and prognosis of a regional series of 26 anaplastic thyroid carcinomas (ATC). Comparison with the literature. Ann Endocrinol (Paris); 2010 Feb;71(1):38-45
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  • [Title] Epidemiology, clinical presentation, treatment and prognosis of a regional series of 26 anaplastic thyroid carcinomas (ATC). Comparison with the literature.
  • OBJECTIVE: The aim of this study is to retrospectively describe the epidemiological and clinical features, therapeutic modalities, prognostic factors and survival figures in a population of patients with anaplastic thyroid carcinoma (ATC) observed in Auvergne, France.
  • The male/female ratio was 1/2.7 and the average age: 72.1; 76.9% of the cases had thyroid medical history, average tumor size at diagnosis was 7.35 cm with N1 in the course of illness in 61.5% of cases, M1 in 34.6% of cases.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy

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  • [Copyright] Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 19959159.001).
  • [ISSN] 0003-4266
  • [Journal-full-title] Annales d'endocrinologie
  • [ISO-abbreviation] Ann. Endocrinol. (Paris)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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3. Daneshbod Y, Omidvari S, Daneshbod K, Negahban S, Dehghani M: Diffuse large B cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by FNA: a case report. Cytojournal; 2006;3:23
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  • [Title] Diffuse large B cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by FNA: a case report.
  • BACKGROUND: Both thyroid lymphoma and anaplastic carcinoma of thyroid present with rapidly growing mass in eldery patients.
  • Anaplastic carcinoma has high mortality rate and combination of surgery, radiation therapy and multidrug chemotherapy are the best chance for cure.
  • Fine needle aspiration was done and reported as anaplastic carcinoma of thyroid which thyroidectomy was planned.
  • After review, with initial diagnosis of anaplastic carcinoma versus lymphoma, immunocytochemical study was performed.
  • CONCLUSION: Despite previous reports, stating easy diagnosis of high-grade thyroid lymphoma on the grounds of cytomorphological features we like to emphasize, overlapping cytologic features of the curable high grade thyroid lymphoma form noncurable anaplastic thyroid carcinoma and usefulness of immunocytochemistry to differentiate these two disease.

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  • (PMID = 17052355.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1630693
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4. Madore J, Ren F, Filali-Mouhim A, Sanchez L, Köbel M, Tonin PN, Huntsman D, Provencher DM, Mes-Masson AM: Characterization of the molecular differences between ovarian endometrioid carcinoma and ovarian serous carcinoma. J Pathol; 2010 Feb;220(3):392-400
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  • [Title] Characterization of the molecular differences between ovarian endometrioid carcinoma and ovarian serous carcinoma.
  • The histopathological diagnosis of high-grade endometrioid and serous carcinoma of the ovary is poorly reproducible under the current morphology based classification system, especially for anaplastic, high-grade tumours.
  • In EOCs, WT1 protein is observed in the majority of serous carcinomas and in up to 30% of endometrioid carcinomas.
  • It is unclear whether the latter is a reflection of the actual incidence of WT1 protein expression in endometrioid carcinomas, or whether a significant number of high-grade serous carcinomas have been misclassified as endometrioid carcinoma.
  • The aim of this study was to better define the molecular characteristics of serous and endometrioid carcinomas in an attempt to address the problems with the current histopathological classification methods.
  • Gene expression profiles were analysed to identify reproducible gene expression phenotypes for endometrioid and serous carcinomas.
  • It was found that nuclear WT1 protein expression can identify misclassified high-grade endometrioid carcinomas and these tumours should be reassigned to serous histotype.
  • Although low-grade endometrioid carcinomas rarely progress to high-grade carcinomas, a combined WT1-negative, TP53-positive immunophenotype may identify an uncommon high-grade subtype of ovarian endometrioid carcinoma.
  • [MeSH-major] Carcinoma, Endometrioid / genetics. Cystadenocarcinoma, Serous / genetics. Ovarian Neoplasms / genetics

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  • [Copyright] Copyright 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • [CommentIn] J Pathol. 2010 Sep;222(1):117; author reply 118 [20572050.001]
  • (PMID = 19967725.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Databank-accession-numbers] GEO/ GSE6008
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Neoplasm Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 0 / WT1 Proteins; 0 / beta Catenin; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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5. Schultz KA, Sencer SF, Messinger Y, Neglia JP, Steiner ME: Pediatric ovarian tumors: a review of 67 cases. Pediatr Blood Cancer; 2005 Feb;44(2):167-73
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  • Thirty-seven patients had malignant tumors: 11 immature teratomas, seven malignant mixed germ cell tumors, seven juvenile granulosa cell tumors, five dysgerminomas, two endodermal sinus tumors, two serous papillary cystadenocarcinomas, one small cell carcinoma, one anaplastic sex-cord tumor, and one undifferentiated sarcoma.
  • Almost all neoplasms presented as unilateral masses and rarely were metastatic at diagnosis.
  • Ovarian tumors must be considered in the differential diagnosis of young girls with abdominal pain, mass, or other non-specific symptoms.
  • [MeSH-major] Ovarian Neoplasms / diagnosis

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  • (PMID = 15490488.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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6. Koussis H, Maruzzo M, Scola A, Ide EC, Fassina A, Marioni G, Lora O, Corti L, Karachontziti P, Jirillo A: A case of anaplastic thyroid cancer with long-term survival. Anticancer Res; 2010 Apr;30(4):1273-8
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  • [Title] A case of anaplastic thyroid cancer with long-term survival.
  • Anaplastic thyroid carcinoma (ATC) (less than 10% of all thyroid cancer) is a high-grade neoplasm, characterized by an aggressive clinical course and refractoriness to currently available local and systemic modalities of treatment.
  • It is considered the most aggressive solid tumour, there is no adequate therapy for this disease and few patients with ATC live more than 1 year following diagnosis.
  • She is still alive 58 months from diagnosis.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy


7. Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S: A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid; 2009 Oct;19(10):1077-84
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  • [Title] A novel orthotopic mouse model of human anaplastic thyroid carcinoma.
  • Most of the human thyroid carcinoma cell lines used in orthotopic or subcutaneous models are likely of melanoma and colon cancer.
  • Here, we report and characterize a novel orthotopic model of human thyroid carcinoma using a unique thyroid cancer cell line.
  • METHODS: We used the cell line 8505c, originated from a thyroid tumor histologically characterized by anaplastic carcinoma cell features.
  • CONCLUSIONS: Here we describe a novel orthotopic thyroid carcinoma model using 8505c cells.
  • [MeSH-major] Carcinoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 19772429.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA149738
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Other-IDs] NLM/ PMC2833178
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8. Peparini N, Di Matteo FM, Maturo A, Marzullo A, Campana FP: Unusual metastasis of gastrointestinal stromal tumor misdiagnosed as anaplastic thyroid carcinoma. Int J Surg; 2008 Oct;6(5):415-7
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  • [Title] Unusual metastasis of gastrointestinal stromal tumor misdiagnosed as anaplastic thyroid carcinoma.
  • [MeSH-major] Carcinoma / pathology. Diagnostic Errors. Gastrointestinal Stromal Tumors / secondary. Stomach Neoplasms / pathology. Thyroid Neoplasms / secondary. Thyroid Neoplasms / surgery
  • [MeSH-minor] Aged. Biopsy, Needle. Diagnosis, Differential. Follow-Up Studies. Gastroscopy / methods. Humans. Immunohistochemistry. Male. Rare Diseases. Risk Assessment. Thyroidectomy / methods

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  • (PMID = 18947815.001).
  • [ISSN] 1743-9159
  • [Journal-full-title] International journal of surgery (London, England)
  • [ISO-abbreviation] Int J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Mekni A, Limaiem F, Cherif K, Chelly I, Sahtout S, Bellil K, Bellil S, Kchir N, Zitouna M, Haouet S: [Value of intraoperative frozen-section analysis in thyroid surgery]. Presse Med; 2008 Jun;37(6 Pt 1):949-55
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  • AIM OF STUDY: To assess the value of intraoperative frozen-section diagnosis in thyroid surgery and determine its limitations.
  • RESULTS: In our series, frozen-section diagnosis was concordant with subsequent histopathological examination in 92% of cases, discordant in 3%, and deferred in 5%.
  • Its sensitivity for thyroid cancer was lower in follicular (42%) and papillary carcinoma (64%) than medullary (100%), anaplastic (100%), secondary (100%), mixed (100%), and insular carcinomas (86%).
  • CONCLUSION: In our series, as in the literature, most of the discordances between frozen-section and definitive diagnosis were associated with microfollicular lesions, which explain the low sensitivity of 67%.

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  • (PMID = 18329238.001).
  • [ISSN] 2213-0276
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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10. Lam KY, Lo CY, Wei WI: Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior. Endocr Pathol; 2005;16(1):83-9
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  • [Title] Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and aggressive biological behavior.
  • Warthin tumor-like variant of papillary thyroid carcinoma is uncommon and approx 80 cases have been reported in the literature.
  • In this report, a Warthin tumor-like variant of the papillary thyroid carcinoma, 5-cm in maximum dimension, underwent anaplastic changes in a 74-yr-old woman.
  • The tumor was positive for CD15 and EMA, and a high proliferative index was noted in the anaplastic area.
  • The present case is the first reported case of Warthin tumor-like variant of papillary thyroid carcinoma with anaplastic changes.
  • [MeSH-major] Adenolymphoma / pathology. Carcinoma, Papillary / secondary. Cell Transformation, Neoplastic / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16000851.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD15; 0 / Biomarkers, Tumor; 0 / Mucin-1
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11. Fukushima T, Takenoshita S: Roles of RAS and BRAF mutations in thyroid carcinogenesis. Fukushima J Med Sci; 2005 Dec;51(2):67-75
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  • Papillary carcinoma and follicular carcinoma are types of differentiated thyroid carcinomas, develop from the same thyroid follicular epithelial cells and show distinct biological behavior.
  • Although several studies have demonstrated differences in the biological characteristics of these carcinomas, little is known about the genetic backgrounds that underlie these differences.
  • Recently, aberrant activation of RAS-RAF-MEK-MAP kinase signaling pathway is frequently found in thyroid carcinoma.
  • In our series, BRAF mutation was detected exclusively in papillary carcinoma (54%), and was exclusively V599E (a single nucleotide change of A-T at nucleotide 1796).
  • NRAS mutation was observed in follicular carcinoma (50%) and in anaplastic carcinoma (28%), and was exclusively Q61R (a single nucleotide change of A-G at nucleotide 182).
  • [MeSH-minor] Adenocarcinoma, Follicular / etiology. Adenocarcinoma, Follicular / genetics. Base Sequence. Carcinoma, Papillary / etiology. Carcinoma, Papillary / genetics. DNA, Neoplasm / genetics. Humans. MAP Kinase Signaling System. Mutation

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  • (PMID = 16555627.001).
  • [ISSN] 0016-2590
  • [Journal-full-title] Fukushima journal of medical science
  • [ISO-abbreviation] Fukushima J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Number-of-references] 27
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12. Yamada H, Takano T, Ito Y, Matsuzuka F, Miya A, Kobayashi K, Yoshida H, Watanabe M, Iwatani Y, Miyauchi A: Expression of nestin mRNA is a differentiation marker in thyroid tumors. Cancer Lett; 2009 Jul 18;280(1):61-4
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  • Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors.
  • [MeSH-major] Carcinoma / metabolism. Gene Expression Regulation, Neoplastic. Intermediate Filament Proteins / biosynthesis. Nerve Tissue Proteins / biosynthesis. RNA, Messenger / metabolism. Thyroid Neoplasms / metabolism

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  • (PMID = 19268442.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
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13. Trimboli P, Ulisse S, Graziano FM, Marzullo A, Ruggieri M, Calvanese A, Piccirilli F, Cavaliere R, Fumarola A, D'Armiento M: Trend in thyroid carcinoma size, age at diagnosis, and histology in a retrospective study of 500 cases diagnosed over 20 years. Thyroid; 2006 Nov;16(11):1151-5
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  • [Title] Trend in thyroid carcinoma size, age at diagnosis, and histology in a retrospective study of 500 cases diagnosed over 20 years.
  • Recently, the Italian Network of Cancer Registries analyzed 5101 cases of thyroid carcinoma showing a reduction of mortality rate of 4%/year.
  • This prompts us to evaluate the temporal trend in tumor size, age at diagnosis, and histology in a retrospective analysis of 500 thyroid cancers diagnosed over 20 years.
  • In particular, papillary thyroid carcinoma (PTC) size decreased from 28 +/- 1.2mm to 14 +/- 0.8mm and follicular carcinoma from 40 +/- 6.3mm to 17 +/- 4.5 mm.
  • Age at diagnosis of all carcinomas increased significantly from 40 +/- 1.3 years in the first group to 48 +/- 0.9 years in the second group.
  • Analysis of the histological types revealed a significant increase of PTC rate in the second decade from 82% to 92% and a concomitant reduction of anaplastic thyroid carcinoma (ATC) from 3.7% to 1.0%.
  • In conclusion, it may be speculated that the above mentioned decreased mortality rate for thyroid carcinoma could be related to the significant reduction with time of cancer size, to the progressive increase of PTC rate and to the reduction of ATC rate.
  • [MeSH-major] Carcinoma, Papillary / mortality. Carcinoma, Papillary / pathology. Thyroid Neoplasms / mortality. Thyroid Neoplasms / pathology
  • [MeSH-minor] Age Distribution. Carcinoma / mortality. Carcinoma / pathology. Cell Differentiation. Humans. Italy / epidemiology. Mortality / trends. Registries / statistics & numerical data. Retrospective Studies. Sex Distribution

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  • (PMID = 17123342.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Ji Y, Kuang TT, Tan YS, Chen Y, Zeng HY, Jin DY: Pancreatic primary lymphoma: a case report and review of the literature. Hepatobiliary Pancreat Dis Int; 2005 Nov;4(4):622-6
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  • The patient received a Whipple's operation and intraoperative frozen sections of the mass showed an anaplastic carcinoma.
  • CONCLUSIONS: The proper diagnosis of the tumor should be made with CD20 and Bcl-6 immunohistochemical study.
  • Radical surgery is indicated for resectable carcinoma but not for a chemosensitive lymphoma.
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16286277.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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15. Gungor T, Altinkaya SO, Akbay S, Bilge U, Mollamahmutoglu L: Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review. Arch Gynecol Obstet; 2010 Mar;281(3):485-90
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  • BACKGROUND: Cystic tumors of ovary, whether benign, borderline, or malignant may be associated with mural nodule of various types, including sarcomas, sarcoma-like mural nodules (SLMN), and foci of anaplastic carcinoma.
  • Cases of serous borderline ovarian tumor with mural nodules of mixed type are very rare.
  • However, too few cases of mixed type mural nodules have been published to warrant a conclusion regarding their prognosis.

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  • (PMID = 19597831.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 39
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16. Raju G, Kameswaran M: Unusual presentations of thyroid malignancies - a case series. Indian J Otolaryngol Head Neck Surg; 2009 Sep;61(3):230-4
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  • These cases highlight certain important issues concerning the diagnosis and management.

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  • [Cites] J Otolaryngol. 1979 Oct;8(5):401-10 [501775.001]
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  • (PMID = 23120642.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3449984
  • [Keywords] NOTNLM ; Carcinoma, Adenoid cystic / Carcinoma, Anaplastic / Carcinoma, Papillary / Lingual thyroid / Paucicellular variant / Riedel’s thyroiditis / Trachea
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17. Rekhi B, Kane SV, D'Cruz A: Cytomorphology of anaplastic giant cell type of medullary thyroid carcinoma--a diagnostic dilemma in an elderly female: a case report. Diagn Cytopathol; 2008 Feb;36(2):136-8
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  • [Title] Cytomorphology of anaplastic giant cell type of medullary thyroid carcinoma--a diagnostic dilemma in an elderly female: a case report.
  • [MeSH-major] Carcinoma, Giant Cell / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Calcitonin / metabolism. Carcinoembryonic Antigen / metabolism. Cell Nucleus / pathology. Chromogranins / metabolism. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 18181195.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Chromogranins; 9007-12-9 / Calcitonin
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18. Naranjo-Gómez JM, Folqué-Gómez E, Moreno-Mata N, Moldes-Rodríguez M, Martínez-Martínez P, González-Aragoneses F, Orusco-Palomino E: [Insular carcinoma of the thyroid. An uncommon but aggressive neoplasm]. Cir Esp; 2005 Apr;77(4):236-9
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  • [Title] [Insular carcinoma of the thyroid. An uncommon but aggressive neoplasm].
  • [Transliterated title] Carcinoma insular de tiroides. Una neoplasia poco frecuente pero agresiva.
  • Insular carcinoma of the thyroid is an infrequent entity, named in 1984 by Carcangiu when he described its characteristic histology.
  • Clinically and morphologically it is considered to be in an intermediate position between well-differentiated carcinoma of the thyroid (papillary or follicular) and undifferentiated or anaplastic carcinoma of the thyroid.
  • The prognosis of this tumor is worse than that of classic carcinoma of the thyroid, and most authors advise aggressive therapy, which in some cases can achieved prolonged survival.
  • [MeSH-major] Carcinoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16420925.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 12
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19. Little JW: Thyroid disorders. Part III: neoplastic thyroid disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 Sep;102(3):275-80
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  • However, 5% to 10% of the lesions that come to medical attention are carcinomas.
  • History, clinical findings, ultrasonography, and fine-needle aspiration biopsy are the mainstays for diagnosis.
  • There are 3 main histologic types of thyroid cancer: differentiated, medullary, and anaplastic.
  • Differentiated lesions are subdivided into papillary, follicular, and Hurthle cell carcinomas.
  • An important neoplastic syndrome, multiple endocrine neoplasia type 2 (MEN2), involves medullary carcinoma of the thyroid gland.
  • The overall 10-year survival for papillary carcinoma is 80% to 90%, follicular carcinoma 65% to 75%, and medullary carcinoma 60% to 70%.
  • The prognosis for anaplastic carcinoma is very poor and 5-year survival is rare.
  • Patients with identified nodules or enlarged thyroid glands should be referred for diagnosis and treatment.
  • [MeSH-major] Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adenoma / blood. Adenoma / diagnosis. Carcinoma / blood. Carcinoma / diagnosis. Carcinoma, Medullary / blood. Carcinoma, Medullary / diagnosis. Diagnosis, Differential. Humans

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  • (PMID = 16920533.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Jakab C, Rusvai M, Gálfi P, Mándoki M, Demeter Z, Szabó Z, Kulka J: Expression of claudin-5 in hepatoid gland biopsies. Vet Dermatol; 2010 Jun;21(3):276-81
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  • These included normal hepatoid glands (n = 10), nodular hyperplasia (n = 10), adenomas (n = 12), epitheliomas (n = 15), differentiated carcinomas (n = 15) and anaplastic carcinomas (n = 15).
  • Claudin-5 expression seemed to be helpful in distinguishing poorly differentiated carcinomas, differentiated carcinomas and epitheliomas of the hepatoid glands.
  • Increased claudin-5 expression by invasive anaplastic carcinomas may facilitate invasion and metastasis through the activation of matrix metalloproteinases.
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Adenoma / veterinary. Animals. Biopsy. Carcinoma / metabolism. Carcinoma / pathology. Carcinoma / veterinary. Dogs. Endothelium / pathology. Female. Hyperplasia / veterinary. Male. Skin / pathology. Tight Junctions / metabolism. Tight Junctions / pathology

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  • (PMID = 20136787.001).
  • [ISSN] 1365-3164
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Claudins
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21. Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, Iaccarino A, Russo M, Pierantoni GM, Leone V, Sacchetti S, Troncone G, Santoro M, Fusco A: Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Cancer Res; 2008 Aug 15;68(16):6770-8
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  • Using gene expression profiling, we found that the CBX7 gene was drastically down-regulated in six thyroid carcinoma cell lines versus control cells.
  • The aims of this study were to determine whether CBX7 is related to the thyroid cancer phenotype and to try to identify new tools for the diagnosis and prognosis of thyroid cancer.
  • We thus evaluated CBX7 expression in various snap-frozen and paraffin-embedded thyroid carcinoma tissues of different degrees of malignancy by quantitative reverse transcription-PCR and immunohistochemistry, respectively.
  • Indeed, it decreased in an increasing percentage of cases going from benign adenomas to papillary (PTC), follicular, and anaplastic (ATC) thyroid carcinomas.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Carcinoma / genetics. Carcinoma, Papillary / genetics. Repressor Proteins / genetics. Repressor Proteins / metabolism. Thyroid Neoplasms / genetics

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  • (PMID = 18701502.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CBX7 protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Repressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
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22. Ito Y, Higashiyama T, Hirokawa M, Fukushima M, Inoue H, Yabuta T, Tomoda C, Uruno T, Kihara M, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Miyauchi A: Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid. Asian J Surg; 2009 Jan;32(1):47-50
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  • [Title] Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid.
  • OBJECTIVE: Anaplastic thyroid carcinoma arises from differentiated carcinoma and has a very aggressive character.
  • In this study, we investigated the prognosis of patients with anaplastic carcinoma based on UICC stage.
  • PATIENTS AND METHODS: We investigated the prognosis of 75 patients who were diagnosed as having anaplastic carcinoma at Kuma Hospital between 1983 and 2006.
  • All patients with Stage IVC died of carcinoma within 1 year regardless of whether locally complete resection was performed.

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  • (PMID = 19321402.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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23. Shikama Y, Mizukami H, Sakai T, Yagihashi N, Okamoto K, Yagihashi S: Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis. J Endocrinol Invest; 2006 Feb;29(2):168-71
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  • [Title] Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis.
  • Spindle cell metaplasia in thyroid adenoma or carcinoma is rare and its pathological features are not well characterized.
  • Distinction of this entity from medullary or anaplastic carcinoma has an important clinical implication.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Metaplasia / pathology. Middle Aged

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  • (PMID = 16610245.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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24. Yokota N, Hashimoto Y, Iida S, Kondo T, Goya N, Toma H, Tanabe K: [Two cases of prostatic carcinoma causing a disorder of gastrointestinal transit due to rectal stenosis]. Hinyokika Kiyo; 2009 Aug;55(8):517-21
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  • [Title] [Two cases of prostatic carcinoma causing a disorder of gastrointestinal transit due to rectal stenosis].
  • Biopsy specimens taken from a prostatic tumor through a transrectal route showed histological features consistent with anaplastic adenocarcinoma which was positively stained with PSA antibody.
  • The eviscerated samples showed no abnormality in the rectal mucous membrane but cancer with light PSA staining in the prostatic ducts.
  • The hormone therapy was initiated in the patient under the diagnosis of anaplastic cancer in the prostate.


25. King AD, Yeung DK, Ahuja AT, Tse GM, Chan AB, Lam SS, van Hasselt AC: In vivo 1H MR spectroscopy of thyroid carcinoma. Eur J Radiol; 2005 Apr;54(1):112-7
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  • [Title] In vivo 1H MR spectroscopy of thyroid carcinoma.
  • To determine if proton magnetic resonance spectroscopy (1H MRS) of thyroid carcinoma is feasible and to determine if 1H MRS spectra of malignant tumors differ from that of normal thyroid tissue.
  • Spectra acquired from six primary tumors (three anaplastic carcinomas, two papillary carcinomas and one follicular carcinoma) and two nodes (two papillary carcinoma metastases) were analyzed in the time-domain using a non-linear least squares fitting algorithm with incorporation of prior knowledge.
  • Choline (3.2 ppm) was identified in all solid carcinomas with a mean choline/creatine of 4.3 at TE 136 ms and 5.4 at TE 272 ms.
  • Ratios for malignant tumors at TE 136 ms ranged from 1.6 in well differentiated follicular carcinoma to 9.4 in anaplastic carcinoma.
  • [MeSH-major] Carcinoma / diagnosis. Magnetic Resonance Spectroscopy / methods. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Algorithms. Choline / metabolism. Creatine / metabolism. Diagnosis, Differential. Female. Humans. Least-Squares Analysis. Male. Middle Aged

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  • (PMID = 15797300.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] MU72812GK0 / Creatine; N91BDP6H0X / Choline
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26. Chiu CG, Harrison PB, Filipenko D, Wiseman SM: Thyroid invasion by locally advanced esophageal cancer masquerading as anaplastic carcinoma. Thyroid; 2008 Jul;18(7):799-800
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  • [Title] Thyroid invasion by locally advanced esophageal cancer masquerading as anaplastic carcinoma.
  • [MeSH-major] Carcinoma / diagnosis. Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Invasiveness


27. Wang HM, Huang YW, Huang JS, Wang CH, Kok VC, Hung CM, Chen HM, Tzen CY: Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma. Ann Surg Oncol; 2007 Oct;14(10):3011-8
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  • [Title] Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma.
  • BACKGROUND: Anaplastic thyroid carcinoma (ATC), a rare and highly malignant tumor, has long been thought to arise from well-differentiated carcinoma (WDC) such as follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC).
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Papillary / genetics. Biomarkers, Tumor / genetics. Carcinoma / genetics. Cell Transformation, Neoplastic / genetics. Neoplasms, Multiple Primary / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 17638058.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Codon; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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28. Papi G, Corrado S, LiVolsi VA: Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol; 2006 Jun;125 Suppl:S95-123
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  • Primary T-SCL can be derivedfromfollicular, C-cell (parafollicular), or mesenchymal components and may be the result of reactive or neoplastic processes, including post-fine-needle aspiration spindle cell nodules, Riedel thyroiditis, solitary fibrous tumor, leiomyoma, peripheral nerve sheath tumor, hyalinizing trabecular tumor, spindle epithelial tumor with thymus-like differentiation, follicular dendritic cell tumor, medullary carcinoma, papillary carcinoma, anaplastic carcinoma, sarcoma, squamous cell carcinoma, and carcinoma showing thymus-like differentiation.

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  • (PMID = 16830961.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 354
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29. Zafon C, Obiols G, Castellví J, Tallada N, Baena JA, Simó R, Mesa J: Clinical significance of RET/PTC and p53 protein expression in sporadic papillary thyroid carcinoma. Histopathology; 2007 Jan;50(2):225-31
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  • [Title] Clinical significance of RET/PTC and p53 protein expression in sporadic papillary thyroid carcinoma.
  • AIMS: Rearranged during Transfection (RET)/papillary thyroid carcinoma (PTC) and p53 are two genes involved in the pathogenesis of PTC.
  • It has been suggested that RET/PTC expression is associated with higher rates of local extension and lymph node involvement, whereas p53 mutations are more frequent in poorly differentiated and anaplastic carcinomas.
  • RET/PTC expression was associated with extrathyroid extension of PTC, at diagnosis (P < 0.05).
  • [MeSH-major] Carcinoma / metabolism. Proto-Oncogene Proteins c-ret / genetics. Thyroid Neoplasms / metabolism. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 17222251.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / RET protein, human
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30. Malle D, Valeri RM, Pazaitou-Panajiotou K, Kiziridou A, Vainas I, Destouni C: Use of a thin-layer technique in thyroid fine needle aspiration. Acta Cytol; 2006 Jan-Feb;50(1):23-7
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  • RESULTS: Our cases included 279 adenomatoid nodules, 15 cases of Hashimoto thyroiditis, 45 follicular neoplasms, 14 Hürthle cell tumors, 58 papillary carcinomas and 1 5 anaplastic carcinomas.
  • CONCLUSION: Thin-layer cytology improves the diagnostic accuracy of thyroid FNA and offers the possibility of performing new techniques, such as immunocytochemistry, on the same sample in order to detect malignancy as well as the type and origin of thyroid gland neoplasms.
  • [MeSH-major] Adenoma / diagnosis. Adenoma, Oxyphilic / diagnosis. Carcinoma / diagnosis. Hashimoto Disease / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Humans. Immunohistochemistry. Staining and Labeling. Thyroid Nodule / diagnosis. Thyroid Nodule / pathology

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  • [CommentIn] Acta Cytol. 2006 Jan-Feb;50(1):3-4 [16514833.001]
  • (PMID = 16514836.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Sykorova V, Dvorakova S, Ryska A, Vcelak J, Vaclavikova E, Laco J, Kodetova D, Kodet R, Cibula A, Duskova J, Hlobilkova A, Astl J, Vesely D, Betka J, Hoch J, Smutny S, Cap J, Vlcek P, Novak Z, Bendlova B: BRAFV600E mutation in the pathogenesis of a large series of papillary thyroid carcinoma in Czech Republic. J Endocrinol Invest; 2010 May;33(5):318-24
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  • [Title] BRAFV600E mutation in the pathogenesis of a large series of papillary thyroid carcinoma in Czech Republic.
  • BACKGROUND: Activating point mutation of the BRAF gene, the most common genetic alteration reported in papillary thyroid carcinomas (PTC), has been associated with poor prognostic characteristics.
  • SUBJECTS AND METHODS: DNAs were extracted from 242 PTCs, 23 sporadic medullary carcinomas, one anaplastic carcinoma and 6 poorly differentiated carcinomas.
  • RESULTS: BRAFV600E mutation was detected in 81 of 242 PTCs (33.5%), in one of 6 poorly differentiated carcinomas (16.7%) and in anaplastic carcinoma.
  • The mutation correlated with a higher age at diagnosis (p=0.049) and with a greater tumor size (p=0.041).
  • [MeSH-major] Carcinoma, Papillary / genetics. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 20009493.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Codon; 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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32. Carda C, Ferrer J, Vilanova M, Peydró A, Llombart-Bosch A: Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases. Virchows Arch; 2005 Jan;446(1):46-51
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  • [Title] Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases.
  • Anaplastic carcinoma of the thyroid gland (ACT) is a highly malignant tumor that is almost invariably associated with a fatal outcome.
  • Both cases disclosed a very similar histological appearance, with a main population of small, pleomorphic, round-to-oval cells arranged in a storiform pattern, admixed with scattered pleomorphic giant cells, an image similar to that of the usual type of MFH.
  • [MeSH-major] Carcinoma / pathology. Rhabdomyosarcoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 15517365.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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33. Shahi N, Abdelhamid MF, Jindall M, Awad RW: Riedel's thyroiditis masquerading as anaplastic thyroid carcinoma: a case report. J Med Case Rep; 2010;4:15
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  • [Title] Riedel's thyroiditis masquerading as anaplastic thyroid carcinoma: a case report.
  • CONCLUSION: It is important for clinicians to be aware of this diagnosis when managing patients with thyroid disease, because Riedel's thyroiditis can mimic malignancy.

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  • (PMID = 20157436.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
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34. Collin AC, Chekaroua K, Delaporte T, Droz JP, Peix JL, Delay E: [Anaplastic thyroid carcinoma: aggressive radical resection and cervical reconstruction. A case report]. Ann Chir; 2006 Dec;131(10):631-5
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  • [Title] [Anaplastic thyroid carcinoma: aggressive radical resection and cervical reconstruction. A case report].
  • [Transliterated title] Chirurgie d'exérèse élargie et reconstruction cervicale pour cancer anaplasique de la thyroïde. A propos d'un cas.
  • STUDY AIM: Anaplastic carcinoma of the thyroid is a rare but highly malignant tumor.
  • PATIENT AND METHODS: We present the case of a patient treated in 1996 for an anaplasic thyroid carcinoma with cervical cutaneous invasion.
  • CONCLUSION: Anaplastic carcinoma is one of more aggressive neoplasm affecting humans.
  • [MeSH-major] Carcinoma / surgery. Neck Dissection / methods. Reconstructive Surgical Procedures / methods. Thyroid Neoplasms / surgery. Thyroidectomy / methods

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  • (PMID = 16824476.001).
  • [ISSN] 0003-3944
  • [Journal-full-title] Annales de chirurgie
  • [ISO-abbreviation] Ann Chir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. Anunobi CC, Banjo AA, Abdulkareem FB, Daramola AO, Akinde OR, Elesha SO: Bladder cancer in Lagos: a 15 year histopathologic review. Niger Postgrad Med J; 2010 Mar;17(1):40-4
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  • The malignant lesions of the bladder showed a male preponderance with a M:F ratio of 4.6:1.
  • Transitional cell carcinoma was the commonest histological type accounting for 61.5% with a male to female ratio of 5:1 and mean age of 59 years.
  • Squamous cell carcinoma accounted for 20.5% with a M:F ratio of 3:1 and showed a mean age of 47 years.
  • Adenocarcinoma, anaplastic carcinoma and embryonal rhabdomyosarcoma accounted for 5.1%, 5.1% and 7.8% of cases respectively.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Transitional Cell / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 20348981.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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36. Dave B, Shet T, Ramadwar M, Kane S: Cytological evaluation of head and neck tumors in children--a pattern analysis. Diagn Cytopathol; 2006 Jun;34(6):434-46
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  • Ninety-four tumors (69.6%) were aspirated for a primary diagnosis, and in 41 (30.4%) cases, fine-needle aspiration cytology was performed to document relapse, recurrence or a metastasis.
  • Among the 94 tumors aspirated for a primary diagnosis, 66 cases (70.2%) were accurately diagnosed, in 22 cases (23.4%) a broad working diagnosis was offered, and 6 cases (6.4%) were misdiagnosed.
  • The smears were broadly divided into six patterns, viz. round cell, epithelial, anaplastic, giant cell, mixed inflammatory, and spindle cell patterns.
  • A fairly good accuracy was seen in the diagnosis of metastatic undifferentiated carcinoma and anaplastic lymphoma, but the giant-cell and spindle-cell tumors continued to pose a problem in diagnosis.
  • [MeSH-major] Cytodiagnosis. Head and Neck Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Biopsy, Fine-Needle. Child. Child, Preschool. Diagnosis, Differential. Diagnostic Errors. Humans. Immunohistochemistry. Sensitivity and Specificity

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  • (PMID = 16680771.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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37. Ito Y, Suzuki T, Yoshida H, Tomoda C, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Yamamoto T, Miyauchi A: Phosphorylation and inactivation of Tob contributes to the progression of papillary carcinoma of the thyroid. Cancer Lett; 2005 Apr 8;220(2):237-42
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  • [Title] Phosphorylation and inactivation of Tob contributes to the progression of papillary carcinoma of the thyroid.
  • A high level of Tob phosphorylation was observed in 42.1% of follicular adenoma, 14.3% of follicular carcinoma.
  • In papillary carcinoma, the Tob phosphorylation level was elevated more frequently than that in follicular carcinoma, and 39.7% of specimens were classified in the high group.
  • Tob phosphorylation level in papillary carcinoma was directly linked to tumor size, lymph node metastasis, extrathyroid extension and the presence of poorly differentiated lesion.
  • In anaplastic carcinoma, surprisingly, Tob phosphorylation was not observed in any cases, but the deficiency of Tob expression was also observed in all these cases.
  • These results suggest that (1) Tob phosphorylation contributes to the progression of papillary carcinoma especially in the later phase through cancellation of its anti-proliferative function, and (2) the deficiency of Tob expression is attributable to the lack of Tob phosphorylation in anaplastic carcinoma.
  • [MeSH-major] Adenoma / genetics. Adenoma / pathology. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Intracellular Signaling Peptides and Proteins / metabolism. Intracellular Signaling Peptides and Proteins / pharmacology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology. Tumor Suppressor Proteins / metabolism. Tumor Suppressor Proteins / pharmacology

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  • (PMID = 15766599.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / TOB1 protein, human; 0 / Tumor Suppressor Proteins
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38. Testini M, Lissidini G, Gurrado A, Lastilla G, Ianora AS, Fiorella R: Acute airway failure secondary to thyroid metastasis from renal carcinoma. World J Surg Oncol; 2008;6:14
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  • [Title] Acute airway failure secondary to thyroid metastasis from renal carcinoma.
  • Acute respiratory crisis due to infiltration of the upper airways is a recognised complication of anaplastic thyroid carcinoma or thyroid lymphoma.
  • Renal cell carcinoma is a tumour that metastasizes diffusely and in an unpredictable manner.
  • A right radical nephrectomy for renal cell carcinoma was performed 8 years previously.
  • Histological examination confirmed the diagnosis of thyroid metastasis from renal cell carcinoma.
  • This appears to be the first case of emergency surgery performed for acute respiratory compromise due to thyroid metastasis from renal cell carcinoma.
  • [MeSH-major] Airway Obstruction / etiology. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Thyroid Neoplasms / complications. Thyroid Neoplasms / secondary

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  • (PMID = 18252002.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2254624
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39. Augustin G, Jelincic Z, Tentor D, Majerovic M, Matosevic P: Hepatoid adenocarcinoma of the stomach: case report and short notes on immunohistochemical markers. Acta Gastroenterol Belg; 2009 Apr-Jun;72(2):253-6
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  • Hepatoid adenocarcinoma of the stomach is a rare type of gastric carcinoma with an extremely poor prognosis.
  • Gastric biopsy revealed a poorly differentiated (anaplastic) adenocarcinoma.
  • After diagnosis of AFP-producing gastric adenocarcinoma, total gastrectomy, with splenectomy, was performed.
  • Because of the poor prognosis for this histological type of tumor, accurate diagnosis of hepatoid adenocarcinoma is important, and long-term follow-up is required.

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  • (PMID = 19637784.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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40. Takeshita H, Kawakami S, Okubo Y, Yamamoto S, Yonese J, Fukui I, Kono A, Kurata M, Inoshita N, Ishikawa Y: [A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining]. Hinyokika Kiyo; 2006 May;52(5):375-8
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  • [Title] [A case of inflammatory myofibroblastic tumor of the urinary bladder finally diagnosed by anaplastic lymphoma kinase (ALK) immunostaining].
  • Since both types of cells were positive for cytokeratin immunostaining, sarcomatoid carcinoma was highly suspected.
  • Since the tumor cells showed spindle cell proliferation alone without epithelial growth and positive staining for anaplastic lymphoma kinase, we corrected the final diagnosis as an inflammatory myofibroblastic tumor of the urinary bladder.
  • [MeSH-minor] Cystoscopy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Pelvic Exenteration. Receptor Protein-Tyrosine Kinases

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  • (PMID = 16758729.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
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41. Raĭkhlin NT, Smirnova EA, Pavlovskaia AI, Rotin DL, Gurevich LE, Savelov NA: [Askenazi (Hurtle) cell tumors of the thyroid]. Arkh Patol; 2005 Nov-Dec;67(6):13-6
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  • Oncocytic follicular carcinomas can be hardly distinguished from oncocytic adenomas.
  • They can be well or poorly differentiated or anaplastic.
  • Oncocytic papillary carcinoma and oncocytic medullary carcinoma are rare.
  • Of key importance in differential diagnosis is electron microscopy (EM) and immunohistochemistry with antimitochondrial antibodies.
  • [MeSH-minor] Aged. Carcinoma, Medullary / diagnosis. Carcinoma, Medullary / metabolism. Carcinoma, Medullary / pathology. Carcinoma, Papillary, Follicular / diagnosis. Carcinoma, Papillary, Follicular / metabolism. Carcinoma, Papillary, Follicular / pathology. Cell Differentiation. Female. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16405013.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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42. Ersoz S, Sert H, Yandi M, Erem C, Mungan S, Ersoz HO, Cobanoglu U, Hacihasanoglu A: The significance of Galectin-3 expression in the immunocytochemical evaluation of thyroid fine needle aspiration cytology. Pathol Oncol Res; 2008 Dec;14(4):457-60
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  • The aim of this study is to evaluate the significance of immunohistochemical expression of Galectin-3 in the differential diagnosis of benign and malignant thyroid nodules.
  • Three cases of five follicular carcinomas had positive staining for Galectin-3, while two had not.
  • Five cases of six papillary carcinomas had positive staining for Galectin-3, while one case (the case with a papillary microcarcinoma) had not.
  • The single cases with medullary and anaplastic carcinomas were negative for Galectin-3.
  • Galectin-3 could be used as a supplementary marker for cytological diagnosis.
  • [MeSH-major] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Papillary / diagnosis. Biomarkers, Tumor / analysis. Galectin 3 / biosynthesis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Sensitivity and Specificity

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  • (PMID = 18415710.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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43. Kuroda N, Iwamura S, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH: Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures. Med Mol Morphol; 2007 Sep;40(3):168-71
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  • [Title] Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures.
  • Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head.
  • The carcinoma components contained adenocarcinoma and squamous cell carcinoma.
  • Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component.
  • Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.
  • [MeSH-major] Carcinoma / pathology. Hyalin / metabolism. Pancreatic Neoplasms / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 17874050.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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44. Buła G, Waler J, Niemiec A, Koziołek H, Bichalski W, Gawrychowski J: Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy. Endokrynol Pol; 2010 Sep-Oct;61(5):427-9
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  • [Title] Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy.
  • RESULTS: Among 7 patients with thyroid metastases from renal clear cell carcinoma, as diagnosed postoperatively, cytology of the thyroid material obtained through FNA revealed follicular tumour in 3 (43%) patients, tumour cells in 2 (28.5%) and atypical cells in the other 2 (28.5%).
  • Intraoperative histopathology confirmed the presence of metastasis from renal clear cell carcinoma (1) and indicated thyroid medullary cancer (1), follicular tumour (4), or trabecular adenoma with necrosis (1).
  • Intraoperative histopathology suggested thyroid anaplastic cancer.
  • CONCLUSIONS: Follicular tumour diagnosed by fine needle aspiration biopsy in patients after treatment for other cancers, especially renal clear cell carcinoma, should alert the surgeon to the possibility that it could be a metastasis of this cancer to the thyroid gland.
  • [MeSH-minor] Adenoma / pathology. Aged. Aged, 80 and over. Biopsy, Fine-Needle. Carcinoma, Neuroendocrine. Female. Humans. Kidney Neoplasms / pathology. Lung Neoplasms / pathology. Male. Middle Aged. Monitoring, Intraoperative / methods

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  • (PMID = 21049452.001).
  • [ISSN] 0423-104X
  • [Journal-full-title] Endokrynologia Polska
  • [ISO-abbreviation] Endokrynol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] Thyroid cancer, medullary
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45. Kim SK, Kim DL, Han HS, Kim WS, Kim SJ, Moon WJ, Oh SY, Hwang TS: Pyrosequencing analysis for detection of a BRAFV600E mutation in an FNAB specimen of thyroid nodules. Diagn Mol Pathol; 2008 Jun;17(2):118-25
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  • However, 10% to 30% of cases with indeterminate cytology in FNAB need other diagnostic tools to refine diagnosis.
  • In detail, 63 (84.0%) of 75 papillary thyroid carcinoma (PTC) samples showed positive BRAF mutation, whereas 3 follicular thyroid carcinomas, 1 anaplastic carcinoma, 1 medullary thyroid carcinoma, and 1 metastatic lung carcinoma did not show BRAF mutation.
  • Out of 27 thyroid nodules classified as 'indeterminate' on cytologic examination preoperatively, 21 (77.8%) cases turned out to be malignant: 18 PTCs (including 2 follicular variant types) and 3 follicular thyroid carcinomas.


46. Nix PA, Nicolaides A, Coatesworth AP: Thyroid cancer review 3: management of medullary and undifferentiated thyroid cancer. Int J Clin Pract; 2006 Jan;60(1):80-4
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  • Over 90% of thyroid cancer is of the differentiated type associated with a very good 10-year disease-free survival rate.
  • In contrast, the rare forms of thyroid cancer which comprise medullary thyroid cancer arising from parafollicluar C cells, Hurthle cell carcinoma, anaplastic carcinoma, thyroid lymphoma and squamous cell carcinoma are typically associated with a poorer survival rate.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Humans. Lymphoma / diagnosis. Neoplasm Staging / methods


47. Rivera M, Ricarte-Filho J, Tuttle RM, Ganly I, Shaha A, Knauf J, Fagin J, Ghossein R: Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension. Thyroid; 2010 Oct;20(10):1085-93
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  • [Title] Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.
  • BACKGROUND: The impact of varying degrees of extrathyroid extension (ETE), especially microscopic ETE (METE), on survival in thyroid carcinomas (TC) has not been well established.
  • Twelve papillary thyroid carcinomas (PTCs) without ETE and NMP were also analyzed.
  • There was a much higher frequency of poorly differentiated and anaplastic carcinomas (12/29, 41%) in patients with gross ETE than in those with METE (3/52, 6%) (p < 0.01).
  • Except for an anaplastic case, no recurrences were detected in 45 patients with METE, including 23 PTC patients followed up for a median of 10 years without radioactive iodine therapy.
  • Fifty-six cases with ETE were genotyped as follows: BRAFV600E, 39 (70%); BRAFV600E-AKT1, 1 (1.8%); NRAS, 1 (1.8%); KRAS, 1 (1.8%); RET/PTC, 3 (5%); wild type, 11 (19.6%).
  • [MeSH-minor] Carcinoma / genetics. Carcinoma, Papillary / pathology. Esophagus / pathology. Humans. Necrosis. Proto-Oncogene Proteins B-raf. Trachea / pathology. Treatment Outcome

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  • (PMID = 20860430.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA050706
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Other-IDs] NLM/ PMC4984786
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48. Jeffrey SC, Nguyen MT, Andreyka JB, Meyer DL, Doronina SO, Senter PD: Dipeptide-based highly potent doxorubicin antibody conjugates. Bioorg Med Chem Lett; 2006 Jan 15;16(2):358-62
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  • Each molecule was conjugated to the mAbs c1F6 (anti-CD70) and cAC10 (anti-CD30) to give potent drug conjugates against renal cell carcinoma and anaplastic large cell lymphoma cell lines, respectively.
  • [MeSH-major] Carcinoma, Renal Cell / drug therapy. Dipeptides / chemistry. Doxorubicin / chemistry. Immunotoxins / chemistry. Immunotoxins / pharmacology. Lymphoma, Large B-Cell, Diffuse / drug therapy

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  • (PMID = 16275070.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Dipeptides; 0 / Immunotoxins; 80168379AG / Doxorubicin
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49. Siironen P, Hagström J, Mäenpää HO, Louhimo J, Heikkilä A, Heiskanen I, Arola J, Haglund C: Anaplastic and poorly differentiated thyroid carcinoma: therapeutic strategies and treatment outcome of 52 consecutive patients. Oncology; 2010;79(5-6):400-8
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  • [Title] Anaplastic and poorly differentiated thyroid carcinoma: therapeutic strategies and treatment outcome of 52 consecutive patients.
  • Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies; poorly differentiated thyroid carcinoma (PDTC) is a new diagnosis for rare aggressive thyroid tumours.
  • Although ATC and PDTC are both aggressive thyroid carcinomas, multimodal therapy for both can provide a chance of prolonged survival in patients with locoregional disease.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Doxorubicin / therapeutic use. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Paclitaxel / therapeutic use. Prognosis. Retrospective Studies. Thyroid Carcinoma, Anaplastic. Thyroid Neoplasms / pathology. Thyroid Neoplasms / therapy. Treatment Outcome

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  • [Copyright] Copyright © 2011 S. Karger AG, Basel.
  • (PMID = 21455012.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel
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50. Ghossein R: Update to the College of American Pathologists reporting on thyroid carcinomas. Head Neck Pathol; 2009 Mar;3(1):86-93
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  • [Title] Update to the College of American Pathologists reporting on thyroid carcinomas.
  • BACKGROUND: The reporting of thyroid carcinomas follows the recommendations of the College of American Pathologists (CAP) protocols and includes papillary carcinoma, follicular carcinoma, anaplastic carcinoma and medullary carcinoma.
  • Despite past and recent efforts, there are a number of controversial issues in the classification and diagnosis of thyroid carcinomas (TC) that, potentially impact on therapy and prognosis of patients with TC.
  • Among the more contentious issues in the pathology of thyroid carcinoma include the defining criteria for tumor invasiveness.
  • It is beyond the scope of this paper to detail the entire CAP protocol for thyroid carcinomas; rather, this paper addresses some of the more problematic issues confronting pathologists in their assessment and reporting of thyroid carcinomas.
  • CONCLUSION: The new CAP protocol for reporting of thyroid carcinomas is a step toward improving the clinical value of the histopathologic reporting of TC.

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  • (PMID = 20596997.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
  • [Other-IDs] NLM/ PMC2807537
  • [Keywords] NOTNLM ; CAP / Capsular / Carcinoma / Extension / Extrathyroid / Invasion / Margins / Minimally invasive / Mitosis / Necrosis / Papillary microcarcinomas / Reporting / Thyroid / Vascular / Widely invasive
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51. Nogales FF, Buriticá C, Regauer S, González T: Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors. Am J Surg Pathol; 2005 Sep;29(9):1247-51
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  • The tumor in the second case consisted of an AFP-positive glandular YST, with a glandulopapillary pattern closely resembling fetal lung type adenocarcinoma, coexisting with an AFP-negative, cytokeratin 20-positive, atypical MC; transitional areas between the two components were also seen.
  • AFP levels became negative during the course of disease paralleling the disappearance of the YST component and the overgrowth of an increasingly anaplastic MC.
  • The patient died 1 year after diagnosis.
  • It is important to differentiate the yolk sac and carcinoid components due to their different responses to chemotherapy and to evaluate the possibility of mucinous carcinoid developing into a highly aggressive carcinoma.

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  • (PMID = 16096416.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / alpha-Fetoproteins
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52. Baloch ZW, LiVolsi VA: Unusual tumors of the thyroid gland. Endocrinol Metab Clin North Am; 2008 Jun;37(2):297-310, vii
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  • These include follicular adenoma and carcinoma (Hürthle and non-Hürthle), and papillary carcinoma and its variants.
  • Other primary epithelial tumors include medullary carcinoma, mixed medullary and follicular carcinomas, insular and poorly differentiated carcinoma, anaplastic carcinoma, and the least common squamous carcinoma and related tumors.
  • In this article, the authors review the unusual tumors of the thyroid, their morphologic features, and clinical and prognostic implications.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / pathology. Rare Diseases / diagnosis. Rare Diseases / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Disease Progression. Humans. Neoplasm Staging. Prognosis. Thyroid Gland / pathology

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  • (PMID = 18502328.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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53. Chakrabarti S, Konar A, Biswas S, Das S: Sarcoma-like mural nodules in ovarian mucinous cystadenomas--a report of two cases. Indian J Med Sci; 2005 Nov;59(11):499-502
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  • The sarcoma-like nodules are associated with a favourable outcome and must be distinguished from other malignant nodules composed of sarcoma or anaplastic carcinoma that may also occur in the wall of mucinous ovarian tumours.

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  • (PMID = 16340150.001).
  • [ISSN] 0019-5359
  • [Journal-full-title] Indian journal of medical sciences
  • [ISO-abbreviation] Indian J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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54. Simeonov R, Simeonova G: Computerized cytomorphometric analysis of nuclear area, nuclear perimeter and mean nuclear diameter in spontaneous canine mammary gland tumours. Vet Res Commun; 2007 Jul;31(5):553-8
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  • Fifty-two spontaneous canine mammary gland tumours (fibroadenomas (n=8), tubulopapillary carcinomas (n=9), solid carcinomas (n=6), anaplastic carcinomas (n=7), fibrosarcomas (n=9), liposarcomas (n=9) and osteosarcomas (n=4) were analysed by computer-assisted nuclear morphometry in Hemacolor-stained cytological specimens.

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  • [Cites] J Comp Pathol. 1997 Aug;117(2):99-105 [9352434.001]
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  • (PMID = 17221362.001).
  • [ISSN] 0165-7380
  • [Journal-full-title] Veterinary research communications
  • [ISO-abbreviation] Vet. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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55. Pavelić K, Dedivitis RA, Kapitanović S, Cacev T, Guirado CR, Danić D, Radosević S, Brkić K, Pegan B, Krizanac S, Kusić Z, Spaventi S, Bura M: Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions. Mutat Res; 2006 Jul 25;599(1-2):45-57
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  • We found higher incidence of p53 mutation and aberrant processing of FHIT mRNA in malignant tumors (papillary, follicular, medullary and anaplastic carcinomas) and in those tumors with distant metastasis.
  • The growth of p53(-)/FHIT(-) follicular carcinoma of human origin was much faster in nude mice than p53(+)/FHIT(+) follicular carcinoma, and mice had shorter survival rate.

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  • (PMID = 16698048.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
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56. Morton RP, Ahmad Z: Thyroid cancer invasion of neck structures: epidemiology, evaluation, staging and management. Curr Opin Otolaryngol Head Neck Surg; 2007 Apr;15(2):89-94
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  • The phenomenon is most common in papillary carcinoma of the thyroid and that is the focus for this review.
  • Less common, but more aggressive tumours (medullary and anaplastic carcinoma) are not considered here.

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  • (PMID = 17413408.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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57. Paksoy M, Aydin S, Ayduran E, Eken M, Sanli A, Taşdemir O: [Clinical signs and management strategies in thyroid masses]. Kulak Burun Bogaz Ihtis Derg; 2008 Sep-Oct;18(5):294-9
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  • Patients with carcinoma associated with neck lymph node metastasis also underwent lateral, anterolateral, modified radical, or radical neck dissections.
  • RESULTS: Postoperative histopathologic diagnoses were benign colloid nodule (n=70), papillary carcinoma (n=16), medullary carcinoma (n=2), anaplastic carcinoma (n=2), and Basedow-Graves disease (n=2).
  • [MeSH-major] Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / surgery

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  • (PMID = 19155675.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Turkey
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58. Koh CS, Ku JL, Park SY, Kim KH, Choi JS, Kim IJ, Park JH, Oh SK, Chung JK, Lee JH, Kim WH, Kim CW, Cho BY, Park JG: Establishment and characterization of cell lines from three human thyroid carcinomas: responses to all-trans-retinoic acid and mutations in the BRAF gene. Mol Cell Endocrinol; 2007 Jan 29;264(1-2):118-27
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  • [Title] Establishment and characterization of cell lines from three human thyroid carcinomas: responses to all-trans-retinoic acid and mutations in the BRAF gene.
  • We report the characteristics of three cell lines (designated, SNU-80, SNU-373 and SNU-790), which were established from two papillary carcinomas and one anaplastic carcinoma obtained from three Korean thyroid carcinoma patients.
  • We believe that these well-characterized thyroid carcinoma cell lines may be useful tools for investigations on the biological characteristics of thyroid carcinoma, particularly for investigations related to gene alterations, especially of the BRAF gene.
  • These cell lines may also be useful for redifferentiation therapy studies on thyroid carcinoma using all-trans-retinoic acid.


59. Muto H, Yamagata K, Inoue M, Nakazawa K, Hashimoto Y, Matsunaga T, Hirayama K, Hattori K, Akaza H, Koyama A: Acute multifocal bacterial nephritis complicated with acute renal failure and thrombocytopenia. Intern Med; 2005 Oct;44(10):1084-7
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  • Due to rapid enlargement of the kidney, we first suspected that she had diffuse renal invasion of anaplastic carcinoma or lymphoma of the kidney.
  • We finally made a diagnosis of acute multifocal bacterial nephritis.

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  • (PMID = 16293922.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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60. Zeng Q, Chen GG, Vlantis AC, van Hasselt CA: Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor-ERK pathway. Cell Prolif; 2007 Dec;40(6):921-35
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  • [Title] Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor-ERK pathway.
  • MATERIALS AND METHODS: Cell proliferation and its related molecules were examined in thyroid papillary carcinoma cells (KAT5), follicular thyroid carcinoma cells (FRO) and anaplastic carcinoma cells (ARO).

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  • (PMID = 18021179.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole; 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Estrogens; 0 / Nitriles; 0 / Phenols; 0 / Propionates; 0 / Pyrazoles; 0 / RNA, Small Interfering; 0 / bcl-2-Associated X Protein; 0 / diarylpropionitrile; 4TI98Z838E / Estradiol; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3
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61. Sidibé el H: [Thyroid diseases in sub-Saharan Africa]. Sante; 2007 Jan-Mar;17(1):33-9
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  • The paucity of laboratories specializing in endocrinology and of nuclear medicine facilities, the delay in diagnosis that results in compressive or recurrent goiters, and endemic goiters are all typical in Africa.
  • Single-nodule tumors were assessed in 89 patients in Khartoum: they were found to be simple goiters in 72% of cases, follicular adenoma in 13.5%, cancer in 13.5% (with 6 of the 12 cases follicular, 5 papillary, and 1 anaplastic).
  • Thyroid cancer at Ibadan was found to be papillary carcinoma in 45.3% of cases; follicular forms were seen in 44.5% and this series includes 5% of medullary cancers (7 cases), with a mean age of 34 years.
  • Thyroid cancers in Algeria are associated with low socioeconomic status and characterized by a high prevalence of cancers discovered at an advanced stage and of anaplastic carcinomas.

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  • (PMID = 17897900.001).
  • [ISSN] 1157-5999
  • [Journal-full-title] Santé (Montrouge, France)
  • [ISO-abbreviation] Sante
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antithyroid Agents; 8KQ660G60G / Carbimazole
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62. Bukhari MH, Niazi S, Hanif G, Qureshi SS, Munir M, Hasan M, Naeem S: An updated audit of fine needle aspiration cytology procedure of solitary thyroid nodule. Diagn Cytopathol; 2008 Feb;36(2):104-12
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  • Only 9 cases (11.84%) were clearly committed as malignant lesions, comprising of papillary carcinoma, anaplastic carcinoma and suggestive of follicular carcinoma.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Clinical Audit. Thyroid Nodule / diagnosis. Thyroid Nodule / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Cross-Sectional Studies. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Pakistan. Prospective Studies. Sensitivity and Specificity. Thyroid Diseases / diagnosis. Thyroid Diseases / pathology. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181183.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Balachandran I, Walker JW Jr, Broman J: Fine needle aspiration cytology of ALK1(-), CD30+ anaplastic large cell lymphoma post renal transplantation: a case report and literature review. Diagn Cytopathol; 2010 Mar;38(3):213-6
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  • [Title] Fine needle aspiration cytology of ALK1(-), CD30+ anaplastic large cell lymphoma post renal transplantation: a case report and literature review.
  • Epstein-Barr virus (EBV) related non-Hodgkin's lymphomas of B-cell type is more common than those of T-cell origin.
  • CD30 positive Anaplastic Large Cell Lymphoma (ALCL) is a Non-Hodgkin's lymphoma (B or T cell type) that accounts for a small percentage of PTLD's.
  • ALCL of T-cell type are a spectrum of disease ranging from primary cutaneous to systemic nodal ALCL.
  • The systemic nodal ALCL is further subdivided into anaplastic lymphoma kinase-1 (ALK-1) positive or negative.
  • [MeSH-major] Antigens, CD30 / analysis. Kidney Transplantation / adverse effects. Lymphoma, Large-Cell, Anaplastic / pathology. Mediastinal Neoplasms / pathology. Protein-Tyrosine Kinases / analysis
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Carcinoma / diagnosis. Cyclophosphamide / therapeutic use. Diagnosis, Differential. Doxorubicin / therapeutic use. Humans. Immunocompromised Host. Immunohistochemistry. Male. Melanoma / diagnosis. Postoperative Complications. Prednisone / therapeutic use. Receptor Protein-Tyrosine Kinases. Remission Induction. Seminoma / diagnosis. Seminoma / secondary. Testicular Neoplasms / diagnosis. Vincristine / therapeutic use

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  • (PMID = 19774614.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Biomarkers, Tumor; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase; VB0R961HZT / Prednisone; CHOP protocol
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64. Okamoto M, Kitajima S, Negishi R, Maehata T, Kouro T, Yamauchi S, Takahashi H, Katakura Y, Watanabe Y, Abiko R, Nakaya S, Inaba H, Takano T, Suzuki M, Itoh F: [Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)]. Nihon Shokakibyo Gakkai Zasshi; 2008 Nov;105(11):1656-65
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  • [Title] [Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)].
  • A huge tumor mass was observed in the tale of the pancreas, which we diagnosed as pancreatic carcinoma.
  • Pathological findings confirmed that it was anaplastic pancreas carcinoma (giant cell type).
  • Autopsy findings confirmed that it was anaplastic pancreas carcinoma (pleomorphic type).
  • Both cases showed positive for epithelial marker and mesenchymal markers and decrease in stainability by E-cadherin staining, a result which suggested diversity of tumor cells in anaplastic pancreas carcinomas.
  • [MeSH-major] Carcinoma / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18987452.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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65. Nucera C, Mazzon E, Caillou B, Violi MA, Moleti M, Priolo C, Sturniolo G, Puzzolo D, Cavallari V, Trimarchi F, Vermiglio F: Human galectin-3 immunoexpression in thyroid follicular adenomas with cell atypia. J Endocrinol Invest; 2005 Feb;28(2):106-12
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  • Increasing hgal-3 immunoexpression has been reported in several human tumors, including thyroid carcinomas, but not in benign thyroid lesions.
  • Hgal-3 immunoperoxidase reaction was carried out on 133 thyroid tissue samples obtained from 113 patients; 20 of these were normal (NT), 85 were benign thyroid lesions [20 colloid nodules (CN), 21 nodular hyperplasias (NH), 7 focal lymphocytic thyroiditis (FLT), 15 Hashimoto's thyroiditis (HT), 22 follicular adenomas (FA)], 25 differentiated carcinomas [15 papillary carcinomas (PC), 6 follicular carcinomas (FC) and 4 Hürthle cell carcinomas (HC)] and 3 anaplastic carcinomas (AC).
  • Hgal-3 cytoplasmic-perinuclear immunolocalization was observed in the majority of thyroid carcinomas and in more than half of the FA, theoretically suggesting an involvement of this protein in thyroid tumorigenesis throughout an antiapoptotic activity.

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  • (PMID = 15887854.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Galectin 3
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66. Sato K, Waseda R, Tatsuzawa Y, Soma R, Ueda Y, Katsuda S: Papillary thyroid carcinoma with anaplastic transformation showing a rhabdoid phenotype solely in the cervical lymph node metastasis. Pathol Res Pract; 2006;202(1):55-9
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  • [Title] Papillary thyroid carcinoma with anaplastic transformation showing a rhabdoid phenotype solely in the cervical lymph node metastasis.
  • We describe a rare case of anaplastically transformed papillary thyroid carcinoma with a rhabdoid phenotype appearing solely in a metastatic focus.
  • Examination of surgically resected specimens disclosed that the thyroid tumor was a well-differentiated papillary carcinoma (2.0 cm in diameter), and the right lateral cervical mass was an anaplastic carcinoma (2.4 cm in diameter) showing a rhabdoid phenotype with scant amounts of a papillary carcinoma component in the periphery, considered to be transformed through the metastasis of the papillary thyroid carcinoma in a cervical lymph node.
  • [MeSH-major] Carcinoma, Papillary / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery

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  • (PMID = 16310972.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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67. Grundy RG, Wilne SH, Robinson KJ, Ironside JW, Cox T, Chong WK, Michalski A, Campbell RH, Bailey CC, Thorp N, Pizer B, Punt J, Walker DA, Ellison DW, Machin D, Children's Cancer and Leukaemia Group (formerly UKCCSG) Brain Tumour Committee: Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer; 2010 Jan;46(1):120-33
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  • METHODS: Ninety-seven children were enrolled between March 1993 and July 2003 and, following diagnostic review, comprised: medulloblastoma (n=31), astrocytoma (26), choroid plexus carcinoma [CPC] (15), CNS PNET (11), atypical teratoid/rhabdoid tumours [AT/RT] (6) and ineligible (6).
  • FINDINGS: Over all diagnostic groups the cumulative progression rate was 80.9% at 5 years while the corresponding need-for-radiotherapy rate for progression was 54.6%, but both rates varied by tumour type.
  • Patients with medulloblastoma presented as a high-risk group, 83.9% having residual disease and/or metastases at diagnosis.
  • All children with large cell or anaplastic variants of medulloblastoma died within 2 years of diagnosis.
  • INTERPRETATION: The outcome for very young children with brain tumours is dictated by degree of surgical resection and histological tumour type and underlying biology as an indicator of treatment sensitivity.
  • Desmoplastic/nodular sub-type of medulloblastoma has a better prognosis than classic histology, despite traditional adverse clinical features of metastatic disease and incomplete surgical resection.

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  • (PMID = 19818598.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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68. Pinchot SN, Sippel RS, Chen H: Multi-targeted approach in the treatment of thyroid cancer. Ther Clin Risk Manag; 2008 Oct;4(5):935-47
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  • While accounting for only 1% of solid organ malignancies (9% in women), thyroid carcinoma is the most common malignancy of the endocrine system.
  • Although most patients have a favorable prognosis, over 1,500 people will die from thyroid carcinoma each year.
  • The spectrum of disease types range from papillary thyroid cancer, which is a well-differentiated indolent tumor, to anaplastic carcinoma, a poorly differentiated fulminant cancer.
  • With advances in diagnostic methods, surgical techniques, and clinical care of patients with thyroid carcinoma, the current management of thyroid cancer demands a multidisciplinary approach.
  • The majority of patients with well-differentiated thyroid carcinoma of follicular cell origin are cured with adequate surgical management; however, some thyroid malignancies such as medullary thyroid carcinoma (MTC) or poorly differentiated thyroid carcinomas frequently metastasize, precluding patients from a curative resection.
  • Here, we explore the current management of thyroid carcinoma, including surgical management of the primary tumor, lymph node disease, and locoregional recurrence.

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  • (PMID = 19209276.001).
  • [ISSN] 1176-6336
  • [Journal-full-title] Therapeutics and clinical risk management
  • [ISO-abbreviation] Ther Clin Risk Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2621417
  • [Keywords] NOTNLM ; RET tyrosine kinase (RTK) / epidermal growth factor receptor (EGFR) / glycogen synthase kinase-3β (GSK-3β) / thyroid carcinoma / vascular endothelial growth factor receptor (VEGFR)
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69. Sevinç AI, Canda AE, Unek T, Canda S, Kocdor MA, Saydam S, Harmancioglu O: Papillary thyroid carcinoma mimicking anaplastic thyroid carcinoma following fine-needle aspiration biopsy. Thyroid; 2010 Jan;20(1):115-7
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  • [Title] Papillary thyroid carcinoma mimicking anaplastic thyroid carcinoma following fine-needle aspiration biopsy.
  • BACKGROUND: Cutaneous metastases from well-differentiated thyroid carcinomas are rare and usually identified in patients with widely disseminated disease.
  • A second FNAB with ultrasound guidance yielded cytology diagnostic of papillary thyroid carcinoma.
  • Papillary thyroid carcinoma was confirmed by surgical dissection of the mass, and a linear array of tumor was noted in skin and muscle was performed again, and the cytological diagnosis revealed papillary carcinoma.
  • After surgical resection, the histopathological diagnosis determined the nodules to be papillary carcinoma.
  • CONCLUSION: Although FNAB is a useful tool for the diagnosis of thyroid nodules, it is important to consider the risk of tumor cell dissemination.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Carcinoma / pathology. Carcinoma, Papillary / pathology. Head and Neck Neoplasms / secondary. Neoplasm Seeding. Skin Neoplasms / secondary. Thyroid Nodule / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Female. Humans. Skin Ulcer / etiology

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  • (PMID = 20017616.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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70. Han SS, Jang JY, Kim SW, Kim WH, Lee KU, Park YH: Analysis of long-term survivors after surgical resection for pancreatic cancer. Pancreas; 2006 Apr;32(3):271-5
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  • Histological reevaluation in the long-term survivors revealed 4 cases of variant adenocarcinoma (anaplastic carcinoma, mucinous noncystic adenocarcinoma [n = 2], and undifferentiated carcinoma).
  • [MeSH-minor] Carcinoma, Pancreatic Ductal / mortality. Carcinoma, Pancreatic Ductal / pathology. Carcinoma, Pancreatic Ductal / surgery. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate. Survivors

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  • (PMID = 16628082.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Jiang JY, Tseng FY: Prognostic factors of anaplastic thyroid carcinoma. J Endocrinol Invest; 2006 Jan;29(1):11-7
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  • [Title] Prognostic factors of anaplastic thyroid carcinoma.
  • BACKGROUND AND PURPOSE: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies.
  • [MeSH-major] Carcinoma / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Goiter / complications. Humans. Leukocytosis / complications. Leukocytosis / diagnosis. Male. Middle Aged. Prognosis. Regression Analysis. Retrospective Studies. Serum Albumin / analysis. Survival Rate. Thyroxine / blood

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  • (PMID = 16553028.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Serum Albumin; Q51BO43MG4 / Thyroxine
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72. Hillesheim PB, Farghaly H: Anaplastic spindle cell carcinoma, arising in a background of an ovarian mucinous cystic tumor: a case report with clinical follow up, review of the literature. Int J Clin Exp Pathol; 2010;3(8):808-11
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  • [Title] Anaplastic spindle cell carcinoma, arising in a background of an ovarian mucinous cystic tumor: a case report with clinical follow up, review of the literature.
  • Anaplastic carcinoma (AC) of spindle cell type is an exceedingly rare ovarian malignant neoplasm.
  • To date, there have been less than ten cases of anaplastic spindle cell carcinoma reported in the medical literature.
  • Furthermore, our case is the first time this tumor has been described in a 40-year-old female with malignant spindle cells merging with conventional high grade adeno-carcinoma.
  • The differential diagnosis of spindle cell proliferation in the ovary will be discussed and their distinction using a panel of immunohistochemical stains.
  • [MeSH-major] Carcinoma / pathology. Cystadenocarcinoma, Mucinous / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinosarcoma / diagnosis. Diagnosis, Differential. Endometriosis / diagnosis. Female. Humans. Sarcoma / diagnosis. Treatment Outcome

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  • (PMID = 21151395.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2993232
  • [Keywords] NOTNLM ; Ovary / anaplastic carcinoma / case report / mucinous neoplasm / spindle cell
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73. Wakatsuki T, Irisawa A, Imamura H, Terashima M, Shibukawa G, Takagi T, Takahashi Y, Sato A, Sato M, Ikeda T, Suzuki R, Hikichi T, Obara K, Ohira H: Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing. Int J Clin Oncol; 2010 Jun;15(3):310-3
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  • [Title] Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing.
  • Histopathologic results revealed anaplastic carcinoma of the pancreas.
  • [MeSH-major] Carcinoma / drug therapy. Drug Screening Assays, Antitumor. Paclitaxel / therapeutic use. Pancreatic Neoplasms / drug therapy. Tubulin Modulators / therapeutic use

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  • (PMID = 20195681.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Tubulin Modulators; 8L70Q75FXE / Adenosine Triphosphate; P88XT4IS4D / Paclitaxel
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74. Kelten C, Kabukcu S, Sen N, Teke Z, Yaren A, Erdem E, Duzcan E: Secondary involvement of the breast in T-cell non-Hodgkin lymphoma, an unusual example mimicking inflammatory breast carcinoma. Arch Gynecol Obstet; 2009 Jul;280(1):149-52
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  • [Title] Secondary involvement of the breast in T-cell non-Hodgkin lymphoma, an unusual example mimicking inflammatory breast carcinoma.
  • The histologic and immunohistochemical features were diagnosed as an ALK (-) anaplastic large cell lymphoma.
  • Thirty months after the diagnosis, the patient is still alive with disease.
  • Because of the presence of systemic symptoms such as skin involvement and generalized lymphadenopathies (mediastinal, axillary or cervical), T cell lymphoma cases with breast involvement could mimic the clinical presentation of inflammatory breast carcinoma.
  • Pathologic examination is needed for the correct diagnosis.
  • [MeSH-major] Breast Neoplasms / secondary. Lymphoma, Large-Cell, Anaplastic / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Lymph Nodes / pathology. Mammography. Neoplasm Staging. Tomography, X-Ray Computed


75. Hunt JL: Unusual thyroid tumors: a review of pathologic and molecular diagnosis. Expert Rev Mol Diagn; 2005 Sep;5(5):725-34
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  • [Title] Unusual thyroid tumors: a review of pathologic and molecular diagnosis.
  • The most common thyroid neoplasms are either follicular derived (papillary, follicular and Hürthle cell lesions) or C-cell derived (medullary carcinoma).
  • The diagnosis of these tumors can usually be made at the histologic level, with immunohistochemical stains necessary in some circumstances.
  • These less common thyroid tumors include tall cell and cribriform-morular variants of papillary carcinoma, hyalinizing trabecular tumor, mucoepidermoid and sclerosing mucoepidermoid carcinoma with eosinophilia, poorly differentiated (insular) carcinoma, and undifferentiated (anaplastic) carcinoma.
  • [MeSH-major] Molecular Diagnostic Techniques. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Cell Differentiation. Humans

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  • (PMID = 16149875.001).
  • [ISSN] 1744-8352
  • [Journal-full-title] Expert review of molecular diagnostics
  • [ISO-abbreviation] Expert Rev. Mol. Diagn.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 116
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76. Nara S: A case of anaplastic carcinoma of the pancreas with portal vein tumor thrombus. Jpn J Clin Oncol; 2010 Jan;40(1):96-7
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  • [Title] A case of anaplastic carcinoma of the pancreas with portal vein tumor thrombus.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Portal Vein / radiography. Thrombosis / radiography

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  • (PMID = 20044390.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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77. Du ZX, Wang HQ, Zhang HY, Gao DX: Involvement of glyceraldehyde-3-phosphate dehydrogenase in tumor necrosis factor-related apoptosis-inducing ligand-mediated death of thyroid cancer cells. Endocrinology; 2007 Sep;148(9):4352-61
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  • TNF-related apoptosis-inducing ligand (TRAIL) is cytotoxic to most thyroid cancer cell lines, including those originating from anaplastic carcinomas, implying TRAIL as a promising therapeutic agent against thyroid cancers.

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  • (PMID = 17540725.001).
  • [ISSN] 0013-7227
  • [Journal-full-title] Endocrinology
  • [ISO-abbreviation] Endocrinology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 0 / TNF-Related Apoptosis-Inducing Ligand; EC 1.2.1.9 / Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); EC 3.4.22.- / Caspase 3
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78. Das DK: Serous effusions in malignant lymphomas: a review. Diagn Cytopathol; 2006 May;34(5):335-47
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  • Cytologic features of specific lymphoma subtypes such as lymphoblastic lymphoma, follicular center cell lymphoma, including Burkitt-type lymphoma, marginal zone lymphoma, MALT lymphoma, and anaplastic large-cell lymphoma, etc., have been described in the literature.
  • ICC not only distinguishes lymphomas from reactive lymphocytoses and SRCTs, it significantly modifies the morphologic diagnosis to achieve a better classification of lymphomas.
  • Cytomorphologically, PEL is usually a large-cell lymphoma, which appears to bridge features of large-cell immunoblastic and anaplastic large-cell lymphoma (ALCL).
  • Most of these cases comprise a unique subgroup of B-cell lymphoma, with features of both high-grade anaplastic and B-immunoblastic lymphoma, but T-cell and/or natural killer cell immunophenotypes are described.
  • In such situations, cytology along with ancillary studies not only gives a quick diagnosis of lymphoma, but also offers prognostically significant information such as classification of lymphomas, its grade and immunophenotype, and presence/absence of viral DNAs and tumor lysis syndrome.
  • [MeSH-minor] Ascitic Fluid / pathology. Carcinoma, Small Cell / pathology. Diagnosis, Differential. Female. Hodgkin Disease / pathology. Humans. Immunophenotyping. Lymphocytosis / pathology. Male. Pericardial Effusion / etiology. Pericardial Effusion / pathology. Reed-Sternberg Cells / pathology

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  • (PMID = 16604559.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 136
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79. Sasaki T, Rodig SJ, Chirieac LR, Jänne PA: The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer; 2010 Jul;46(10):1773-80
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  • The fusion between echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) has recently been identified in a subset of non-small cell lung cancers (NSCLCs).
  • This review will focus on the biology, clinical characteristics, diagnosis and treatment of EML4-ALK NSCLC.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20418096.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA136851-02; United States / NCI NIH HHS / CA / R01 CA136851; United States / NCI NIH HHS / CA / R01 CA136851-02; United States / NCI NIH HHS / CA / R01CA136851
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / EML4-ALK fusion protein, human; 0 / Enzyme Inhibitors; 0 / Oncogene Proteins, Fusion; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
  • [Other-IDs] NLM/ NIHMS195408; NLM/ PMC2888755
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80. Buergy D, Weber T, Maurer GD, Mudduluru G, Medved F, Leupold JH, Brauckhoff M, Post S, Dralle H, Allgayer H: Urokinase receptor, MMP-1 and MMP-9 are markers to differentiate prognosis, adenoma and carcinoma in thyroid malignancies. Int J Cancer; 2009 Aug 15;125(4):894-901
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  • [Title] Urokinase receptor, MMP-1 and MMP-9 are markers to differentiate prognosis, adenoma and carcinoma in thyroid malignancies.
  • The identification of high-risk patients with thyroid cancer and the preoperative differentiation between follicular adenoma and carcinoma remain clinically challenging.
  • Our study was conducted to analyze whether the quantification of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator receptor (u-PAR) and transcription factor binding to the u-PAR promoter improve prognostic predictability and differential diagnosis of thyroid tumors.
  • Tumor/normal tissue was collected from 69 prospectively followed patients with thyroid carcinomas (papillary, medullary, follicular and anaplastic, PTC, MTC, FTC and ATC) or follicular adenomas.
  • Carcinomas except MTC expressed significantly more u-PAR/MMPs than adenomas/normal tissues, this being associated with advanced pT- or M-stages.
  • MMP-1 and MMP-9 were significantly higher in follicular carcinomas than in adenomas.
  • In carcinomas, high u-PAR-gene expression correlated significantly with high MMP-9, the latter being associated with MMP-7 in normal tissues.
  • Poor survival in differentiated tumors was associated in trend (p = 0.07); poor survival of all patients (p = 0.043) and especially of patients with carcinomas of follicular origin (including ATC), but not medullary carcinomas, were significantly associated with high u-PAR-protein (p = 0.015).
  • Quantification of u-PAR is of prognostic relevance in thyroid carcinomas of non-c-cell origin, and u-PAR in part may be regulated nontranscriptionally in thyroid cancers.
  • This is the first study to suggest MMP-1/-9 as significant differentiation markers between follicular adenoma and follicular carcinoma.
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adult. Aged. Blotting, Western. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Electrophoretic Mobility Shift Assay. Female. Humans. Immunoenzyme Techniques. Luciferases. Male. Matrix Metalloproteinase 7 / metabolism. Middle Aged. Prognosis. Promoter Regions, Genetic / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Transfection

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  • (PMID = 19480010.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / RNA, Messenger; 0 / Receptors, Urokinase Plasminogen Activator; EC 1.13.12.- / Luciferases; EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.7 / Matrix Metalloproteinase 1
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81. Ulisse S, Baldini E, Toller M, Marchioni E, Giacomelli L, De Antoni E, Ferretti E, Marzullo A, Graziano FM, Trimboli P, Biordi L, Curcio F, Gulino A, Ambesi-Impiombato FS, D'Armiento M: Differential expression of the components of the plasminogen activating system in human thyroid tumour derived cell lines and papillary carcinomas. Eur J Cancer; 2006 Oct;42(15):2631-8
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  • [Title] Differential expression of the components of the plasminogen activating system in human thyroid tumour derived cell lines and papillary carcinomas.
  • We characterised the expression of the plasminogen activators (uPA and tPA), the uPA receptor (uPAR) and the PAs inhibitors (PAI-1 and PAI-2) in human thyroid cell lines derived from normal thyroid, follicular adenoma, follicular, papillary and anaplastic carcinomas.
  • Quantitative RT-PCR analysis showed that uPA, uPAR and PAI-1 mRNAs increased in all carcinoma cells.
  • Similar results were found in 13 papillary thyroid carcinoma (PTC) tissues which were mirrored in Western blot experiments.
  • In conclusion, thyroid carcinoma cell lines and PTC overexpress uPA, uPAR and PAI-1 and the correlation of uPA and its cognate receptor with tumour size and metastasis may suggest their potential prognostic relevance in thyroid cancer.
  • [MeSH-major] Carcinoma, Papillary / metabolism. Neoplasm Proteins / metabolism. Plasminogen Activators / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Blotting, Western. Cell Line, Tumor. Humans. Neoplasm Metastasis. Prognosis. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Urokinase-Type Plasminogen Activator / metabolism

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  • (PMID = 16928445.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 3.4.21.- / Plasminogen Activators; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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82. Nikiforov YE: Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment? J Clin Endocrinol Metab; 2005 Feb;90(2):1243-5
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  • [Title] Editorial: anaplastic carcinoma of the thyroid--will aurora B light a path for treatment?
  • [MeSH-major] Carcinoma / genetics. Protein-Serine-Threonine Kinases / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 15699543.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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83. Fujita T, Ogasawara Y, Naito M, Doihara H, Shimizu N: Anaplastic thyroid carcinoma associated with granulocyte colony-stimulating factor: report of a case. Surg Today; 2006;36(1):63-7
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  • [Title] Anaplastic thyroid carcinoma associated with granulocyte colony-stimulating factor: report of a case.
  • She had undergone a resection of thyroid carcinoma 13 years earlier, followed by two subsequent operations for recurrent thyroid disease.
  • Surgery was thus performed to control persistent bleeding from the axillary ulcer, and a histopathological examination resulted in a diagnosis of poorly differentiated thyroid carcinoma.
  • [MeSH-major] Carcinoma, Papillary / complications. Granulocyte Colony-Stimulating Factor. Leukocytosis / etiology. Thyroid Neoplasms / complications

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  • (PMID = 16378196.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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84. Hacıhanefioğlu A, Tarkun P, Gonullu E, Vardar O: Lymphomas of Waldeyer's ring: Clinical features, management and prognosis of eleven adult patients. Turk J Haematol; 2008 Jun 5;25(2):75-8
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  • Lymphoma is the second most common neoplasm of the head and neck after squamous carcinoma.
  • Complete remission was achieved in 6 patients and partial remission in 3 patients; 1 patient did not achieve remission and 1 patient with anaplastic large cell lymphoma died.
  • The progression of patients with lymphoma is closely associated with the diagnosis, stage and histologic grade of the disease.

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  • (PMID = 27264443.001).
  • [ISSN] 1300-7777
  • [Journal-full-title] Turkish journal of haematology : official journal of Turkish Society of Haematology
  • [ISO-abbreviation] Turk J Haematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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85. Reddi HV, Madde P, Reichert-Eberhardt AJ, Galanis EC, Copland JA, McIver B, Grebe SK, Eberhardt NL: ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude mice. Cancer Gene Ther; 2008 Nov;15(11):750-7
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  • [Title] ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude mice.
  • Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer variant, accounting for 1-2% of all cases, but 33% of deaths, and exhibiting an average life expectancy of 5 months.
  • In the present study, we report that ONYX-411 is able to induce cell death in eight human anaplastic carcinoma cell lines in vitro.

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  • (PMID = 18583996.001).
  • [ISSN] 1476-5500
  • [Journal-full-title] Cancer gene therapy
  • [ISO-abbreviation] Cancer Gene Ther.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA080117; United States / NCI NIH HHS / CA / CA80117
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS321376; NLM/ PMC3180921
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86. Moscetti L, Padalino D, Capomolla E, Nelli F, Pollera CF: A partial response in anaplastic carcinoma of the thyroid with liposomal doxorubicin. J Exp Clin Cancer Res; 2005 Mar;24(1):151-4
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  • [Title] A partial response in anaplastic carcinoma of the thyroid with liposomal doxorubicin.
  • Anaplastic thyroid carcinoma is a rare disease with a poor prognosis.
  • Herein we report the first case of an anaplastic thyroid carcinoma treated with the use of liposomal doxorubicin.

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  • (PMID = 15943045.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Liposomes; 80168379AG / Doxorubicin
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87. Sands NB, Karls S, Rivera J, Tamilia M, Hier MP, Black MJ, Gologan O, Payne RJ: Preoperative serum thyroglobulin as an adjunct to fine-needle aspiration in predicting well-differentiated thyroid cancer. J Otolaryngol Head Neck Surg; 2010 Dec;39(6):669-73
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  • Patients with nonindeterminate FNAB or final pathology containing medullary carcinoma, anaplastic carcinoma, or lymphoma were excluded.

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  • (PMID = 21144363.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9010-34-8 / Thyroglobulin
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88. Kościuch J, Zielonka TM, Ziółkowski B, Domagała-Kulawik J, Bogacka-Zatorska E, Chazan R: [Breast carcinoma and anaplastic gastric carcinoma with pleural metastases in patient after mastectomy 30 years ago]. Pneumonol Alergol Pol; 2006;74(1):129-31
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  • [Title] [Breast carcinoma and anaplastic gastric carcinoma with pleural metastases in patient after mastectomy 30 years ago].
  • We describe a case of two simultaneous malignancies--anaplastic gastric carcinoma with pleural metastases and left breast carcinoma.
  • Her parents died from malignancies--mother from gastric cancer and father from pulmonary carcinoma.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma / pathology. Carcinoma / secondary. Neoplasms, Multiple Primary / pathology. Pleural Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 17175993.001).
  • [ISSN] 0867-7077
  • [Journal-full-title] Pneumonologia i alergologia polska
  • [ISO-abbreviation] Pneumonol Alergol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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89. Adamidou A, Kotsaftis P, Vlachou M, Haritanti A, Xanthakis I, Zantidis A, Ntaios G: Solitary large hepatic metastasis in an elderly patient with anaplastic thyroid carcinoma: a case report. Cases J; 2009;2(1):41
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  • [Title] Solitary large hepatic metastasis in an elderly patient with anaplastic thyroid carcinoma: a case report.
  • BACKGROUND: We present the case of a patient who presented with anaplastic thyroid carcinoma with a solitary large liver metastasis.
  • Hepatic metastases are extremely rare in anaplastic thyroid carcinoma.
  • The findings of fine-needle aspiration biopsy of the thyroid were consistent with anaplastic carcinoma.
  • Liver biopsy showed infiltrations by poorly differentiated anaplastic cells, few of which were slightly positive for thyroglobulin.
  • These findings were suggestive of a hepatic metastasis originating from anaplastic thyroid carcinoma.
  • CONCLUSION: Solitary, large hepatic metastasis may constitute a rare complication in anaplastic thyroid carcinoma.

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  • [Cites] Ann Surg Oncol. 2006 Apr;13(4):453-64 [16474910.001]
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  • (PMID = 19138396.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2632615
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90. Besic N, Hocevar M, Zgajnar J: Lower incidence of anaplastic carcinoma after higher iodination of salt in Slovenia. Thyroid; 2010 Jun;20(6):623-6
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  • [Title] Lower incidence of anaplastic carcinoma after higher iodination of salt in Slovenia.
  • BACKGROUND: Anaplastic thyroid carcinoma (ATC) may arise de novo or from a preexistent differentiated carcinoma.
  • It is well known that higher iodine intake in the diet causes higher frequency of papillary thyroid carcinoma, but decreases the frequency of follicular thyroid carcinoma.
  • [MeSH-major] Carcinoma / epidemiology. Potassium Iodide / administration & dosage. Thyroid Neoplasms / epidemiology

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  • [CommentIn] Thyroid. 2010 Jun;20(6):581-2 [20553193.001]
  • (PMID = 20470204.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sodium Chloride, Dietary; 1C4QK22F9J / Potassium Iodide
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91. Daneshbod Y, Oryan A, Khojasteh HN, Rasekhi A, Ahmadi N, Mohammadianpanah M: Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature. J Pediatr Hematol Oncol; 2010 Mar;32(2):e75-8
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  • [Title] Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature.
  • OBSERVATION: In this report, a rare case of anaplastic lymphoma kinase (ALK)-positive anaplastic large T-cell lymphoma in the breast of a 16-year-old female without breast implant is described.
  • Clinically, inflammatory breast carcinoma was highly suspected.
  • The immunohistochemical profile showed positivity for CD30 and ALK and confirmed the diagnosis of ALK-positive anaplastic large T-cell lymphoma of the breast.
  • CONCLUSION: Anaplastic large T-cell lymphoma of the breast is rare, and can clinically mimic inflammatory breast carcinoma in adolescence.
  • [MeSH-major] Breast Neoplasms / pathology. Lymphoma, Large-Cell, Anaplastic / pathology. Protein-Tyrosine Kinases / analysis


92. Tamura G, Miyoshi H, Ogata SY, Sasou S, Kudoh S, Kikuchi J, Yanagawa N, Motoyama T: Parathyroid carcinoma with anaplastic feature: association of a p53 gene mutation with anaplastic transformation. Pathol Int; 2009 Feb;59(2):107-10
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  • [Title] Parathyroid carcinoma with anaplastic feature: association of a p53 gene mutation with anaplastic transformation.
  • Parathyroid carcinoma is a rare neoplasm that accounts for only 1-3% of cases of primary hyperparathyroidism.
  • Parathyroid carcinoma is a well-differentiated tumor that is sometimes difficult to differentiate histopathologically from its benign counterpart, parathyroid adenoma.
  • The present report describes parathyroid carcinoma with anaplastic transformation of differentiated parathyroid carcinoma in a patient with primary hyperparathyroidism.
  • Nuclear accumulation of p53 protein was found in anaplastic carcinoma cells but not in differentiated carcinoma cells.
  • Polymerase chain reaction-single-strand conformation polymorphism followed by direct sequencing showed that anaplastic carcinoma cells carried a missense mutation at codon 248 (CGG to CAG) of the p53 gene, while the remaining differentiated carcinoma cells had the wild-type p53 gene.
  • These findings suggest that the p53 gene mutation is associated with anaplastic transformation of parathyroid carcinoma.
  • [MeSH-major] Carcinoma / pathology. Cell Transformation, Neoplastic / pathology. Genes, p53. Mutation, Missense. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Nucleus / metabolism. DNA Mutational Analysis. Humans. Hyperparathyroidism / diagnosis. Hyperparathyroidism / etiology. Male. Parathyroidectomy. Polymorphism, Single-Stranded Conformational. Reverse Transcriptase Polymerase Chain Reaction. Treatment Outcome. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19154265.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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93. Miccoli P, Minuto MN, Berti P, Materazzi G: Update on the diagnosis and treatment of differentiated thyroid cancer. Q J Nucl Med Mol Imaging; 2009 Oct;53(5):465-72
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  • [Title] Update on the diagnosis and treatment of differentiated thyroid cancer.
  • Thus, together with small follicular lesions, "low risk" papillary carcinoma will result the main indication for MIVAT, being this small cancer usually harboured in normal glands of young females.
  • On the other hand, in case of locally invasive carcinomas and/or lymph node metastasis the procedure must be immediately converted to the conventional technique.
  • MIVAT also is not indicated for the treatment of medullary and anaplastic carcinomas.
  • Recent prospective randomized studies clearly demonstrate that MIVAT allows achieving same clearance at the thyroid bed level and same outcome as conventional technique, when dealing with "low risk" papillary carcinoma.
  • [MeSH-major] Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / therapy

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  • (PMID = 19910899.001).
  • [ISSN] 1824-4785
  • [Journal-full-title] The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology
  • [ISO-abbreviation] Q J Nucl Med Mol Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 26
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94. Lacoste-Collin L, d'Aure D, Aziza J, Quintyn ML, Uro-Coste E, Courtade-Saïdi M: Cerebrospinal fluid cytologic findings of a pleomorphic xanthoastrocytoma: a case report. Acta Cytol; 2010 Sep-Oct;54(5 Suppl):871-4
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  • Computed tomography of the central nervous system revealed a supracallous periventricular tumor mass suggestive of either a lymphoma or a metastatic carcinoma.
  • A primitive glial proliferation was found, and paraffin-embedded tumor tissue obtained by biopsy confirmed the diagnosis of anaplastic PXA.
  • CONCLUSION: Observation of PXA in CSF might cause some differential diagnosis problems, especially with a metastatic epithelial malignancy.
  • We present a case of anaplastic PXA with an unusual periventricular location and its cytologic features in CSF.

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  • (PMID = 21053559.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Krapp JD, Brauer RB, Matevossian E, Gerauer KE, Thorban S, Becker K, Stangl MJ: Donor transmitted anaplastic carcinoma in a kidney-transplant recipient. Transpl Int; 2005 Sep;18(9):1109-12
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  • [Title] Donor transmitted anaplastic carcinoma in a kidney-transplant recipient.
  • We report a case in which anaplastic carcinoma tumor cells from an organ-donor were transmitted to a kidney transplantation recipient.
  • [MeSH-major] Carcinoma / etiology. Carcinoma / secondary. Kidney Neoplasms / etiology. Kidney Neoplasms / secondary. Kidney Transplantation / adverse effects. Tissue Donors

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  • (PMID = 16101732.001).
  • [ISSN] 0934-0874
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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96. Iyengar P, Reid-Nicholson M, Moreira AL: Pregnancy-associated anaplastic large-cell lymphoma of the breast: a rare mimic of ductal carcinoma. Diagn Cytopathol; 2006 Apr;34(4):298-302
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pregnancy-associated anaplastic large-cell lymphoma of the breast: a rare mimic of ductal carcinoma.
  • Anaplastic large-cell lymphoma (ALCL) is a rare T-cell lymphoma typically seen in children and young adults.
  • We would like to highlight the cytologic and histologic features of ALCL, as this case was initially misdiagnosed as a ductal carcinoma.
  • Differential diagnosis with other tumors is also discussed.
  • [MeSH-major] Breast / pathology. Carcinoma, Ductal, Breast / pathology. Lymphoma, Large-Cell, Anaplastic / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Pregnancy


97. Khashab MA, Emerson RE, DeWitt JM: Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of anaplastic pancreatic carcinoma: a single-center experience. Pancreas; 2010 Jan;39(1):88-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of anaplastic pancreatic carcinoma: a single-center experience.
  • OBJECTIVES: Anaplastic carcinoma of the pancreas (ACP) is an aggressive variant of ductal adenocarcinoma.
  • The aim of this study was to describe a single-center experience with the use of endoscopic ultrasound (EUS) with or without fine-needle aspiration (FNA) for the diagnosis of ACP.
  • METHODS: The cytology and surgical pathology databases were searched for a diagnosis of ACP between 1992 and 2008.
  • The diagnosis of ACP was confirmed after surgical resection in 2 of these 5, including one in whom cytology demonstrated only adenocarcinoma.
  • CONCLUSIONS: Anaplastic carcinoma of the pancreas has variable endosonographic features.
  • Endoscopic ultrasound-FNA may assist in the cytological diagnosis of these tumors.
  • [MeSH-major] Carcinoma / pathology. Pancreas / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle / methods. Carcinoma, Pancreatic Ductal / pathology. Diagnosis, Differential. Endosonography. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Survival Analysis

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  • (PMID = 20050229.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Dresen RC, Beets GH, Vliegen RF, Creytens DH, Beets-Tan RG: Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features. Br J Radiol; 2008 Oct;81(970):e249-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features.
  • Rectal linitis plastica (RLP) is a circumferentially infiltrating intramural anaplastic carcinoma that results in a rigid constricted rectum with thickened walls.
  • A long delay between the onset of symptoms and the diagnosis often occurs because RLP can mimic a lot of diseases and endoscopy and biopsies are often negative, owing to the fact that the mucosa is frequently unaffected in RLP.
  • We present the first report of the MR features of secondary rectal linitis plastica from a bladder carcinoma.
  • It is important to establish the diagnosis of RLP early because of its bad prognosis.
  • The value of MRI in supporting the diagnosis of RLP should not be underestimated.
  • As endoscopy plus biopsy can often be negative, we suggest that, if pelvic MRI shows a concentric double layered thickening of the rectal wall over a long segment, then the diagnosis of RLP should be considered.
  • This should prompt further investigations either to confirm or rule out the diagnosis of RLP by performing endoscopy with deep rectal wall biopsies.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / secondary. Linitis Plastica / secondary. Rectal Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18796553.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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99. De Simone P, Gelin M, El Nakadi I: Amelanotic malignant melanoma of the esophagus. Report of a case. Minerva Chir; 2006 Feb;61(1):45-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report on a patient affected with a primary amelanotic melanoma of the esophagus synchronous to a squamous cell carcinoma of the epiglottis and treated by subtotal esophagectomy.
  • An upper gastrointestinal endoscopy revealed a 3 cm, non pigmented, polypoid mass of the middle esophagus and biopsy was consistent with undifferentiated carcinoma.
  • Fiberoptic bronchoscopy revealed a 0.5 cm, polypoid lesion of the right aspect of the epiglottis consistent with a squamous cell carcinoma.
  • The esophageal neoplasm was treated by subtotal esophagectomy while the squamous cell carcinoma of the epiglottis was referred to radiotherapy 1 month after surgery.
  • Microscopy showed diffuse proliferation of anaplastic cells with multiple mitotic figures, marked nuclei and multilobulated nucleoli.
  • Review of patient's medical history and exploration of skin and mucous membranes failed to reveal malignant lesions and definitive diagnosis was primary amelanotic malignant melanoma of the esophagus.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Epiglottis. Esophageal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Melanoma / pathology. Neoplasms, Multiple Primary / pathology

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  • MedlinePlus Health Information. consumer health - Melanoma.
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  • (PMID = 16568022.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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100. Liu AH, Juan LY, Yang AH, Chen HS, Lin HD: Anaplastic thyroid cancer with uncommon long-term survival. J Chin Med Assoc; 2006 Oct;69(10):489-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic thyroid cancer with uncommon long-term survival.
  • The exception is anaplastic thyroid cancer.
  • Here, we present a patient with anaplastic thyroid cancer who survived for more than 10 years after diagnosis.
  • A 68-year-old man was incidentally found to have anaplastic thyroid cancer during operation for follicular neoplasm.
  • [MeSH-major] Carcinoma / mortality. Thyroid Neoplasms / mortality






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