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1. Daneshbod Y, Omidvari S, Daneshbod K, Negahban S, Dehghani M: Diffuse large B cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by FNA: a case report. Cytojournal; 2006;3:23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffuse large B cell lymphoma of thyroid as a masquerader of anaplastic carcinoma of thyroid, diagnosed by FNA: a case report.
  • BACKGROUND: Both thyroid lymphoma and anaplastic carcinoma of thyroid present with rapidly growing mass in eldery patients.
  • Anaplastic carcinoma has high mortality rate and combination of surgery, radiation therapy and multidrug chemotherapy are the best chance for cure.
  • Fine needle aspiration was done and reported as anaplastic carcinoma of thyroid which thyroidectomy was planned.
  • After review, with initial diagnosis of anaplastic carcinoma versus lymphoma, immunocytochemical study was performed.
  • CONCLUSION: Despite previous reports, stating easy diagnosis of high-grade thyroid lymphoma on the grounds of cytomorphological features we like to emphasize, overlapping cytologic features of the curable high grade thyroid lymphoma form noncurable anaplastic thyroid carcinoma and usefulness of immunocytochemistry to differentiate these two disease.

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  • (PMID = 17052355.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1630693
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2. Hakamada K, Miura T, Kimura A, Nara M, Toyoki Y, Narumi S, Sasak M: Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature. World J Gastroenterol; 2008 Jan 7;14(1):132-5
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  • [Title] Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature.
  • Oncogenesis of anaplastic carcinoma of the pancreas is a subject of controversy, because it shows sarcomatous nature with extremely poor prognosis.
  • We herein report an unusual case of anaplastic carcinoma occurring with a recurrent mucinous cystic neoplasm in a 38-year-old female.
  • A 10-cm retroperitoneal cystic mass was pointed out in the first pregnancy and a probable diagnosis of mucinous cystic neoplasm was made in October 2000.
  • A diagnosis of borderline-type mucinous cystic neoplasm with ovarian-like stroma was made.
  • Pathology revealed that the tumor was composed of two different components of borderline-type mucinous cystic neoplasm and anaplastic carcinoma.
  • Although the origin of anaplastic carcinoma has not been determined yet, it should be remembered that anaplastic carcinoma can occur in association with mucinous cystic neoplasm of more benign histology.
  • [MeSH-major] Carcinoma / pathology. Neoplasms, Cystic, Mucinous, and Serous / pathology. Pancreatic Neoplasms / pathology. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 18176976.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 14
  • [Other-IDs] NLM/ PMC2673378
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3. Ito Y, Arai K, Nozawa R, Yoshida H, Higashiyama T, Takamura Y, Miya A, Kobayashi K, Kuma K, Miyauchi A: S100A10 expression in thyroid neoplasms originating from the follicular epithelium: contribution to the aggressive characteristic of anaplastic carcinoma. Anticancer Res; 2007 Jul-Aug;27(4C):2679-83
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  • [Title] S100A10 expression in thyroid neoplasms originating from the follicular epithelium: contribution to the aggressive characteristic of anaplastic carcinoma.
  • BACKGROUND: S100A10, a member of the S100 family, forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation.
  • Cells stained positively in 14.6% and 20.8% of follicular carcinomas for S100A10 and annexin II, respectively, but their expression levels were always low.
  • S100A10 and annexin II were expressed in all papillary carcinomas, but 88.2% and 82.8% ofpapillary carcinomas were classified in the low group.
  • S100S10 and annexin II were also expressed in all anaplastic carcinomas, with 83.3% of these lesions were classified in the high group.
  • CONCLUSION: These findings suggest that S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma.
  • [MeSH-major] Annexin A2 / biosynthesis. Carcinoma / metabolism. Carcinoma / pathology. S100 Proteins / biosynthesis. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Epithelium / metabolism. Epithelium / pathology. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 17695432.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Annexin A2; 0 / S100 Proteins; 0 / S100 calcium binding protein A10
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4. Pan ZG, Wang B: Anaplastic carcinoma of the pancreas associated with a mucinous cystic adenocarcinoma. A case report and review of the literature. JOP; 2007;8(6):775-82
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  • [Title] Anaplastic carcinoma of the pancreas associated with a mucinous cystic adenocarcinoma. A case report and review of the literature.
  • CONTEXT: Anaplastic carcinoma of the pancreas is a rare undifferentiated variant of ductal adenocarcinoma, which commonly displays sarcomatoid spindle-cell and pleomorphic growth patterns.
  • Anaplastic carcinoma of the pancreas associated with mucinous cystic neoplasm has rarely been reported.
  • CASE REPORT: Here we report a unique case of an anaplastic carcinoma of the pancreas in association with a mucinous cystadenocarcinoma in a 70-year-old woman.
  • The anaplastic component of this tumor is predominantly composed of spindle cells and highly pleomorphic cells that mimic a spindle cell sarcoma.
  • Adjacent to the solid anaplastic tumor is a classic mucinous cystadenocarcinoma, which has strong reactivity to mucin 1, CA 19-9, epithelial membrane antigen (EMA), CK19, CK8/18, carcinoembryonic antigen and CK7.
  • The peri-cystic tissue and the septa consist of an ovarian-type stroma that is strongly positive for CD10.
  • CONCLUSION: The anaplastic carcinoma of the pancreas is of epithelial origin with various microscopic features, and the scattered osteoclast-like giant cells in the tumor are reactive cells of histiocytic origin.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17993730.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Vimentin; 68238-35-7 / Keratins
  • [Number-of-references] 15
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5. Njim L, Moussa A, Hadhri R, Gassab I, Ben Yahia N, Mahmoudi H, Zakhama A: [Angiomatoid tumor of the thyroid gland: primitive angiosarcoma or variant of anaplastic carcinoma?]. Ann Pathol; 2008 Jun;28(3):221-4
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  • [Title] [Angiomatoid tumor of the thyroid gland: primitive angiosarcoma or variant of anaplastic carcinoma?].
  • [Transliterated title] Tumeur angiomatoïde de la thyroïde: angiosarcome primitif ou variante du carcinome anaplasique?
  • The histogenesis of thyroid angiomatoid tumors has been controversial for many years: these tumors may be either a variant of anaplastic carcinoma, or an angiosarcoma.
  • We also discuss, through a review of the literature, the pathologic criteria that could be used to distinguish between angiosarcoma and anaplastic carcinoma of the thyroid.
  • [MeSH-major] Carcinoma / pathology. Hemangiosarcoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Keratins / metabolism

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  • (PMID = 18706366.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 68238-35-7 / Keratins
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6. Ito Y, Higashiyama T, Hirokawa M, Fukushima M, Inoue H, Yabuta T, Tomoda C, Uruno T, Kihara M, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Miyauchi A: Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid. Asian J Surg; 2009 Jan;32(1):47-50
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  • [Title] Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid.
  • OBJECTIVE: Anaplastic thyroid carcinoma arises from differentiated carcinoma and has a very aggressive character.
  • In this study, we investigated the prognosis of patients with anaplastic carcinoma based on UICC stage.
  • PATIENTS AND METHODS: We investigated the prognosis of 75 patients who were diagnosed as having anaplastic carcinoma at Kuma Hospital between 1983 and 2006.
  • All patients with Stage IVC died of carcinoma within 1 year regardless of whether locally complete resection was performed.

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  • (PMID = 19321402.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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7. Takeshita Y, Takamura T, Minato H, Misu H, Ando H, Yamashita T, Ikeda H, Nakanuma Y, Kaneko S: Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy. Intern Med; 2008;47(19):1709-12
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  • [Title] Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy.
  • Multiple liver metastases were incidentally detected in the lobe of the liver of an 81-year-old woman following total thyroidectomy and ablative radioactive iodine administration for the treatment of papillary thyroid carcinoma.
  • A biopsy specimen taken from the metastatic liver tumor was histologically diagnosed as anaplastic carcinoma.
  • We considered this to have been caused by anaplastic transformation from papillary thyroid carcinoma during treatment.
  • We report a rare case of multiple liver metastases from a papillary thyroid carcinoma, which we believe to be the result of anaplastic transformation during postoperative radioactive iodine-131 therapy.
  • [MeSH-major] Carcinoma, Papillary / metabolism. Carcinoma, Papillary / radiotherapy. Iodine Radioisotopes / adverse effects. Liver Neoplasms / secondary. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / radiography. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18827421.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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8. Namikawa T, Hanazaki K: Clinical analysis of primary anaplastic carcinoma of the small intestine. World J Gastroenterol; 2009 Feb 7;15(5):526-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical analysis of primary anaplastic carcinoma of the small intestine.
  • Primary anaplastic carcinoma is a rare variant of small intestinal cancer.
  • Most reports of primary anaplastic carcinoma of the small intestine are isolated case reports, therefore the clinicopathological features, therapeutic management, and surgical outcome of this tumor type remain unclear.
  • This review analyzes the available clinical characteristics of primary anaplastic carcinoma of the small intestine and investigates key differences from differentiated adenocarcinoma of the small intestine.
  • A Medline search was performed using the keywords 'small intestine' and 'anaplastic carcinoma' or 'undifferentiated carcinoma'.
  • The literature revealed a poor prognosis for patients who underwent surgical resection for anaplastic carcinoma of the small intestine, which gave a 3-year overall survival rate of 10.8% and a median survival time of 5.0 mo.
  • The literature suggests that anaplastic carcinoma is markedly more aggressive than differentiated adenocarcinoma of the small intestine.
  • Surgical resection with the aim of complete tumor removal provides the only beneficial therapeutic option for patients with anaplastic carcinoma of the small intestine, because chemotherapy and radiation therapy have no significant effect on the rate of survival.
  • However, despite complete tumor resection, most patients with anaplastic carcinoma of the small intestine are at great risk of disease recurrence.
  • This report also highlights the importance of a systematic diagnostic approach for anaplastic carcinoma of the small intestine.
  • [MeSH-major] Carcinoma / pathology. Intestinal Neoplasms / pathology

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  • (PMID = 19195053.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2653339
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9. Laco J, Ryska A, Celakovský P: [Anaplastic carcinoma of the thyroid gland with chondrosarcomatous component]. Cesk Patol; 2005 Jan;41(1):34-7
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  • [Title] [Anaplastic carcinoma of the thyroid gland with chondrosarcomatous component].
  • [Transliterated title] Anaplastický karcinom stítné zlázy s chondrosarkomatózní komponentou.
  • Fine needle aspiration cytology was performed with the conclusion of a sarcomatoid variant of anaplastic carcinoma of the thyroid gland; biopsy was recommended.
  • The diagnosis of thyroid anaplastic carcinoma with chondrosarcomatous component was established.
  • [MeSH-major] Carcinoma / pathology. Chondrosarcoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 15816122.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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10. Sawai H, Okada Y, Funahashi H, Matsuo Y, Takeyama H, Manabe T: Anaplastic carcinoma of the pancreas with squamous features: report of a case and immunohistochemical study. Med Sci Monit; 2005 Nov;11(11):CS65-8
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  • [Title] Anaplastic carcinoma of the pancreas with squamous features: report of a case and immunohistochemical study.
  • BACKGROUND: Anaplastic carcinomas of the pancreas are rare aggressive tumors with survival measurable in weeks.
  • Many terms have been applied used to describe these tumors, and anaplastic foci are identified in ductal adenocarcinomas and in ectopic pancreata, but are not the dominant pattern of growth.
  • We herein present our experience with a case of anaplastic carcinoma of the pancreas with squamous features in order that allowed us to delineate the clinicopathologic and immunohistochemical features of this rare entity.
  • Histopathologically, anaplastic tumor cells showed focal ductal and squamous features infiltrated into pancreatic parenchyma, extrapancreatic fatty tissue, and stomach.
  • Although immunoreactivity against p53 was negative, strong positive immunostaining for proliferating cell nuclear antigen and interleukin-1 receptor type I (IL-1RI) was observed in a the majority of tumor cells, while the alpha6 integrin subunit was predominantly strong expressed in the adenocarcinomatous lesion.
  • CONCLUSIONS: Our immunohistochemical studies suggested that the prognosis of the case with anaplastic carcinoma presented here would be poor, due to the strong expression of integrins and IL-1RI.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / diagnosis. Integrins / analysis. Pancreatic Neoplasms / diagnosis. Receptors, Interleukin-1 / analysis
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / diagnosis. Fatal Outcome. Humans. Immunohistochemistry. Male. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / secondary. Prognosis

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  • (PMID = 16258403.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Integrins; 0 / Receptors, Interleukin-1
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11. Zhou ZY, Sun RC, Yang GY, Yang SD, Yu MH, Liang JB: Giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity: a distinctive form of thymic carcinoma? Int J Surg Pathol; 2010 Oct;18(5):363-8
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  • [Title] Giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity: a distinctive form of thymic carcinoma?
  • Here, the authors describe a case of giant-cell anaplastic carcinoma with osteoclastic giant cells of the chest cavity-which could be a distinctive form of thymic carcinoma-which expressed CD5 and CD45.
  • The tumor was composed of large areas of necrosis and anaplastic neoplastic giant cells with high mitotic activity, and osteoclast-like cells; there was marked inflammatory cell infiltration.
  • The anaplastic neoplastic giant cells were immunoreactive for CKpan, CD5, CD45, VIM, and p53.
  • Because this tumor is very rare, extensive clinical, radiological, and morphological examinations as well as immunohistochemical studies are essential to make the diagnosis.
  • [MeSH-major] Carcinoma / pathology. Osteoclasts / pathology. Thoracic Cavity / pathology. Thoracic Neoplasms / pathology. Thymus Neoplasms / pathology

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  • (PMID = 20667924.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Biomarkers, Tumor; EC 3.1.3.48 / Antigens, CD45; EC 3.1.3.48 / PTPRC protein, human
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12. Vella J, Cracchiolo B, Heller DS: Anaplastic carcinoma arising in an ovarian mucinous cystadenocarcinoma in a 17-year-old female. J Pediatr Adolesc Gynecol; 2006 Feb;19(1):39-43
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  • [Title] Anaplastic carcinoma arising in an ovarian mucinous cystadenocarcinoma in a 17-year-old female.
  • BACKGROUND: Anaplastic carcinoma arising within a mucinous ovarian neoplasm is rare, with only about 30 reported cases.
  • CASE: We report a case of anaplastic carcinoma arising in a mucinous cystadenocarcinoma in a 17-year-old female who presented with severe abdominal pain, an unusual symptom for an ovarian malignancy in the postmenopausal patient, but not in the adolescent.
  • CONCLUSIONS: This case illustrates that, although rare, epithelial ovarian malignancy is in the differential diagnosis of abdominal pain in an adolescent.
  • [MeSH-major] Abdominal Pain / etiology. Carcinoma / diagnosis. Cystadenocarcinoma, Mucinous / diagnosis. Neoplasms, Multiple Primary / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 16472728.001).
  • [ISSN] 1083-3188
  • [Journal-full-title] Journal of pediatric and adolescent gynecology
  • [ISO-abbreviation] J Pediatr Adolesc Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Califano L, Sanguedolce F, Staibano S, Pannone G, Tortorella S, Serpico R, Lo Muzio L, Bufo P: Large oral soft tissue metastasis from anaplastic carcinoma of the lung mimicking a primitive malignancy: case report and brief review of the literature. Minerva Stomatol; 2008 Sep;57(9):447-51
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  • [Title] Large oral soft tissue metastasis from anaplastic carcinoma of the lung mimicking a primitive malignancy: case report and brief review of the literature.
  • We describe a case of anaplastic carcinoma of the lung in a 60-year-old man, presenting a huge oral metastasis as the first sign of his primitive lung malignancy.
  • Clinically, the oral lesion mimicked a high-grade primitive carcinoma of the oral cavity.
  • We report an uncommon case of metastatic lung carcinoma to the gingiva emphasizing the differential diagnosis between primary and metastatic tumours; a short discussion on the pathways of metastatization to oral cavity soft tissues, as well as brief review of the literature are also presented.
  • [MeSH-major] Carcinoma / prevention & control. Lung Neoplasms / pathology. Mouth Neoplasms / secondary. Soft Tissue Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 18923379.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 8
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14. Nagaiah G, Fu P, Wasman JK, Cooney MM, Mooney C, Afshin D, Lavertu P, Bokar J, Savvides P, Remick SC, CTRU Research Nurses: Phase II trial of sorafenib (bay 43-9006) in patients with advanced anaplastic carcinoma of the thyroid (ATC). J Clin Oncol; 2009 May 20;27(15_suppl):6058

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  • [Title] Phase II trial of sorafenib (bay 43-9006) in patients with advanced anaplastic carcinoma of the thyroid (ATC).
  • This trial is ongoing and supported in part by NIH grant nos. CA62502.

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  • (PMID = 27961935.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Murata T, Terasaki M, Sakaguchi K, Okubo M, Fukami Y, Nishimae K, Kitayama Y, Hoshi S: A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor. Clin J Gastroenterol; 2009 Apr;2(2):109-14

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  • [Title] A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor.
  • We report a case of anaplastic carcinoma of the pancreas with production of granulocyte-colony stimulating factor (G-CSF) in a 59-year-old male.
  • Differential diagnosis included pancreatic tumors and submucosal tumor of the stomach, but definite preoperative diagnosis could not be made.
  • Histological examination showed anaplastic carcinoma of the pancreas.
  • Therefore, we diagnosed the tumor as anaplastic carcinoma of the pancreas producing G-CSF.

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  • (PMID = 26192175.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Anaplastic carcinoma / Granulocyte-colony stimulating factor / Pancreas
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16. Ito Y, Motoo Y, Yoshida H, Iovanna JL, Nakamura Y, Kuma K, Miyauchi A: High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid. Pathology; 2006 Dec;38(6):545-7
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  • [Title] High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid.
  • All 39 (20 minimally invasive and 19 widely invasive) follicular carcinomas and 20 adenomas were negative for or expressed only low levels of TP531NP1 except for one widely invasive follicular carcinoma.
  • Of 100 papillary carcinomas, only four (4%) expressed high levels of TP531NP1, and the remaining 96 (96%) were classified into the low group.
  • There were no significant relationships between TP531NP1 expression and clinicopathological features of papillary carcinoma.
  • However, 36 of the 38 (94.7%) anaplastic carcinomas expressed high levels of TP531NP1 and the incidence was significantly higher (p<0.0001) than that in other neoplasms.
  • CONCLUSIONS: These findings suggest that TP531NP1 plays a significant role in the progression of anaplastic carcinoma or contributes to anaplastic transformation from papillary or follicular carcinoma, which is in sharp contrast to findings in previous in vitro and in vivo studies.
  • [MeSH-major] Carcinoma / metabolism. Carrier Proteins / metabolism. Heat-Shock Proteins / metabolism. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenoma / metabolism. Adenoma / pathology. Carcinoma, Papillary / pathology. Carcinoma, Papillary, Follicular / metabolism. Carcinoma, Papillary, Follicular / pathology. Gene Expression Regulation, Neoplastic. Humans

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  • (PMID = 17393983.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Heat-Shock Proteins; 0 / TP53INP1 protein, human
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17. Kuroda N, Iwamura S, Fujishima N, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH: Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures. Med Mol Morphol; 2007 Sep;40(3):168-71
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  • [Title] Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures.
  • Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head.
  • The carcinoma components contained adenocarcinoma and squamous cell carcinoma.
  • Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component.
  • Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.
  • [MeSH-major] Carcinoma / pathology. Hyalin / metabolism. Pancreatic Neoplasms / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 17874050.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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18. Tamiolakis D, Venizelos I, Nikolaidou S, Lambropoulou M, Bolioti S, Papadopoulos N: Ovarian mucinous cystadenocarcinoma with mural nodule of anaplastic carcinoma and synchronous cervical squamous carcinoma. Cesk Patol; 2005 Apr;41(2):66-70
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  • [Title] Ovarian mucinous cystadenocarcinoma with mural nodule of anaplastic carcinoma and synchronous cervical squamous carcinoma.
  • One especially interesting case involving coincidental cervical carcinoma is presented.
  • The immunohistochemical examination revealed atypical cells in the nodule which were positive for cytokeratin, CEA, and vimentine, establishing its anaplastic nature.
  • A synchronous cervical invasive squamous carcinoma was documented.
  • The occurrence of ovarian mucinous cystadenocarcinoma with mural nodule of anaplastic carcinoma and cervical squamous cell carcinoma is evidently very uncommon, because we have not found a similar case in the literature.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Squamous Cell / pathology. Cystadenocarcinoma, Mucinous / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 15966336.001).
  • [ISSN] 1210-7875
  • [Journal-full-title] Československá patologie
  • [ISO-abbreviation] Cesk Patol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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19. Takano T, Ito Y, Matsuzuka F, Miya A, Kobayashi K, Yoshida H, Miyauchi A: Expression of oncofetal fibronectin mRNA in thyroid anaplastic carcinoma. Jpn J Clin Oncol; 2007 Sep;37(9):647-51
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  • [Title] Expression of oncofetal fibronectin mRNA in thyroid anaplastic carcinoma.
  • BACKGROUND: Oncofetal fibronectin (onfFN) is a fetal protein, the expression of which is observed in papillary thyroid carcinomas but not in follicular tumors or in normal thyroid.
  • Its expression in anaplastic thyroid carcinoma (ATC), however, has not been clarified, since only a few cases had been examined in previous studies.
  • RESULTS: Increased expression of onfFN mRNA was observed in all cases of ATC regardless of the type of accompanying differentiated carcinoma and five of six ATC cell lines.
  • CONCLUSION: These results confirm that expression of onfFN mRNA characterizes not only papillary thyroid carcinoma but also ATC. onfFN mRNA or protein may be a useful marker to identify anaplastic carcinoma cells and may be considered as an optimistic target in molecular-based therapy of ATC.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / chemistry. Fibronectins / analysis. Thyroid Gland / chemistry. Thyroid Neoplasms / chemistry

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  • (PMID = 17704536.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Fibronectins; 0 / RNA, Messenger; 0 / oncofetal fibronectin
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20. Hommell-Fontaine J, Borda A, Ragage F, Berger N, Decaussin-Petrucci M: Nonconventional papillary thyroid carcinomas with pleomorphic tumor giant cells: a diagnostic pitfall with anaplastic carcinoma. Virchows Arch; 2010 Jun;456(6):661-70
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  • [Title] Nonconventional papillary thyroid carcinomas with pleomorphic tumor giant cells: a diagnostic pitfall with anaplastic carcinoma.
  • The presence of pleomorphic tumor giant cells in thyroid carcinomas of follicular cell origin is always worrisome for the pathologist as they first of all refer to anaplastic carcinoma, one of the most aggressive human malignancies.
  • However, non-anaplastic pleomorphic giant cells are well described in other thyroid diseases, most often benign.
  • In this paper, we describe four cases of papillary thyroid carcinoma displaying pleomorphic tumor giant cells with features that differ from those of anaplastic carcinoma.
  • Pleomorphic giant cells were admixed with the underlying thyroid carcinoma and constituted from 5% to 25% of the tumor.
  • Compared to pleomorphic giant cells of anaplastic carcinoma, they reproduced the growth pattern of the underlying carcinoma, had a low mitotic index without necrosis or inflammation, and were reactive with thyroglobulin and thyroid-specific transcription factor-1 and strongly and diffusely positive for cytokeratin AE1/AE3.
  • These cases show that pleomorphic tumor giant cells arising in papillary thyroid carcinomas do not always represent dedifferentiation and progression to anaplastic carcinoma.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Papillary / pathology. Giant Cells / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 20414675.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / TTF1 protein, human; 68238-35-7 / Keratins
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21. Cerilli LA, Frable WJ, Spafford MF: Anaplastic carcinoma of the thyroid with chondroblastoma features mimicking papillary carcinoma: a case report. Acta Cytol; 2007 Sep-Oct;51(5):825-8
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  • [Title] Anaplastic carcinoma of the thyroid with chondroblastoma features mimicking papillary carcinoma: a case report.
  • BACKGROUND: An unusual case of anaplastic carcinoma of the thyroid arising from a metastatic focus of papillary carcinoma.
  • CASE: The tumor affected a 69-year-old woman with a history of total thyroidectomy for papillary thyroid carcinoma 4 years previously.
  • A small, embedded focus of residual follicular variant of papillary carcinoma was present.
  • CONCLUSION: This "chondroblastoma" variant of anaplastic thyroid carcinoma has not been reported to date.
  • [MeSH-major] Carcinoma / pathology. Carcinoma, Papillary / pathology. Chondroblastoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17910356.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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22. Rosati G, Ugolini G, Senatore G, Leone Ornella O, Montroni I, Zanotti S, Manaresi A, Taffurelli M: Sarcomatoid anaplastic carcinoma of the small bowel in cardiac transplant bearer. Minerva Chir; 2008 Aug;63(4):301-6
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  • [Title] Sarcomatoid anaplastic carcinoma of the small bowel in cardiac transplant bearer.
  • Sarcomatoid carcinoma is a rare form of primitive carcinoma of the small bowel; it is considered a variant of adenocarcinoma, histologically characterized by a typical biphasic pattern with epithelial- and mesenchymal-like cells.
  • Histological examination and immunohistochemical stain showed an anaplastic sarcomatoid carcinoma.
  • Early diagnosis is usually very difficult, due to the lack of any stereotyped clinical expression and the difficult to study the small bowel.
  • In most cases, an emergency surgical operation is performed without a clear preoperative diagnosis.
  • [MeSH-major] Carcinoma. Heart Transplantation. Ileal Neoplasms

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  • (PMID = 18607327.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 21
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23. Yamai H, Yoshida T, Toba H, Kira M, Takizawa H, Tangoku A: [A case of anaplastic carcinoma of thyroid administered peroral fluorinated pyrimidine for long-term survival during three years]. Gan To Kagaku Ryoho; 2009 Jun;36(6):1021-4
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  • [Title] [A case of anaplastic carcinoma of thyroid administered peroral fluorinated pyrimidine for long-term survival during three years].
  • We report a case of anaplastic carcinoma of the thyroid administered peroral fluorinated pyrimidine, providing longterm survival during three years.
  • Three years ago, a 70-year-old woman diagnosed with anaplastic carcinoma of the thyroid was admitted for chemoradiation therapy after tumor resection and tracheostomy.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Carcinoma / drug therapy. Oxonic Acid / administration & dosage. Tegafur / administration & dosage. Thyroid Neoplasms / drug therapy

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  • (PMID = 19542729.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 5VT6420TIG / Oxonic Acid; 1-UFT protocol
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24. Krapp JD, Brauer RB, Matevossian E, Gerauer KE, Thorban S, Becker K, Stangl MJ: Donor transmitted anaplastic carcinoma in a kidney-transplant recipient. Transpl Int; 2005 Sep;18(9):1109-12
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  • [Title] Donor transmitted anaplastic carcinoma in a kidney-transplant recipient.
  • We report a case in which anaplastic carcinoma tumor cells from an organ-donor were transmitted to a kidney transplantation recipient.
  • [MeSH-major] Carcinoma / etiology. Carcinoma / secondary. Kidney Neoplasms / etiology. Kidney Neoplasms / secondary. Kidney Transplantation / adverse effects. Tissue Donors

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  • (PMID = 16101732.001).
  • [ISSN] 0934-0874
  • [Journal-full-title] Transplant international : official journal of the European Society for Organ Transplantation
  • [ISO-abbreviation] Transpl. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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25. Besic N, Hocevar M, Zgajnar J, Pogacnik A, Grazio-Frkovic S, Auersperg M: Prognostic factors in anaplastic carcinoma of the thyroid-a multivariate survival analysis of 188 patients. Langenbecks Arch Surg; 2005 Jun;390(3):203-8
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  • [Title] Prognostic factors in anaplastic carcinoma of the thyroid-a multivariate survival analysis of 188 patients.
  • BACKGROUND: Multivariate studies concerning the prognosis of patients with anaplastic carcinoma of the thyroid gland are scarce.
  • The aim of our study was to determine the prognostic factors associated with survival of patients with anaplastic carcinoma in Slovenia, an iodine-deficient region.
  • METHODS: This retrospective study was carried out on a group of 188 patients (130 female, 58 male; median age 68 years) with anaplastic carcinoma of the thyroid who had been treated at a tertiary care centre from 1972 to 2003.

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  • (PMID = 15599758.001).
  • [ISSN] 1435-2443
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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26. Carda C, Ferrer J, Vilanova M, Peydró A, Llombart-Bosch A: Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases. Virchows Arch; 2005 Jan;446(1):46-51
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  • [Title] Anaplastic carcinoma of the thyroid with rhabdomyosarcomatous differentiation: a report of two cases.
  • Anaplastic carcinoma of the thyroid gland (ACT) is a highly malignant tumor that is almost invariably associated with a fatal outcome.
  • Both cases disclosed a very similar histological appearance, with a main population of small, pleomorphic, round-to-oval cells arranged in a storiform pattern, admixed with scattered pleomorphic giant cells, an image similar to that of the usual type of MFH.
  • [MeSH-major] Carcinoma / pathology. Rhabdomyosarcoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 15517365.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / Myoglobin
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27. Provenza C, Young RH, Prat J: Anaplastic carcinoma in mucinous ovarian tumors: a clinicopathologic study of 34 cases emphasizing the crucial impact of stage on prognosis, their histologic spectrum, and overlap with sarcomalike mural nodules. Am J Surg Pathol; 2008 Mar;32(3):383-9
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  • [Title] Anaplastic carcinoma in mucinous ovarian tumors: a clinicopathologic study of 34 cases emphasizing the crucial impact of stage on prognosis, their histologic spectrum, and overlap with sarcomalike mural nodules.
  • The histopathologic features and prognosis of foci/nodules of anaplastic carcinoma are not well known.
  • Slides from 34 consultation cases of mucinous ovarian tumors with foci/nodules of anaplastic carcinoma were reviewed and classified on the basis of their morphologic features.
  • The foci/nodules of anaplastic carcinoma were classified histologically into 3 groups: (a) rhabdoid (n=12) having a diffuse arrangement of cells with large, bright, eosinophilic cytoplasms, eccentric nuclei, and one or more prominent nucleoli;.
  • The presence of foci/nodules of anaplastic carcinoma in unruptured stage I mucinous tumors of the ovary does not necessarily carry an adverse prognosis.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 18300813.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Camargos EF, Pandolfi MB, Toledo MA, Quintas JL, Moreira S Jr, de Azevedo AE, Tavares AC: A 95-year-old woman with leucocytosis and eosinophilia: anaplastic carcinoma in an ectopic thyroid. BMJ Case Rep; 2010;2010:2823
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  • [Title] A 95-year-old woman with leucocytosis and eosinophilia: anaplastic carcinoma in an ectopic thyroid.
  • Within 11 days of diagnosis, the patient died of respiratory failure.
  • This case represents a very rare situation in which a leukemoid reaction and peripheral hypereosinophilia were observed as a manifestation of an anaplastic thyroid carcinoma in an ectopic mass.
  • [MeSH-major] Choristoma / pathology. Eosinophilia / diagnosis. Leukocytosis / diagnosis. Mediastinal Neoplasms / pathology. Thyroid Gland

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  • (PMID = 22767520.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028571
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29. Tamura G, Miyoshi H, Ogata SY, Sasou S, Kudoh S, Kikuchi J, Yanagawa N, Motoyama T: Parathyroid carcinoma with anaplastic feature: association of a p53 gene mutation with anaplastic transformation. Pathol Int; 2009 Feb;59(2):107-10
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  • [Title] Parathyroid carcinoma with anaplastic feature: association of a p53 gene mutation with anaplastic transformation.
  • Parathyroid carcinoma is a rare neoplasm that accounts for only 1-3% of cases of primary hyperparathyroidism.
  • Parathyroid carcinoma is a well-differentiated tumor that is sometimes difficult to differentiate histopathologically from its benign counterpart, parathyroid adenoma.
  • The present report describes parathyroid carcinoma with anaplastic transformation of differentiated parathyroid carcinoma in a patient with primary hyperparathyroidism.
  • Nuclear accumulation of p53 protein was found in anaplastic carcinoma cells but not in differentiated carcinoma cells.
  • Polymerase chain reaction-single-strand conformation polymorphism followed by direct sequencing showed that anaplastic carcinoma cells carried a missense mutation at codon 248 (CGG to CAG) of the p53 gene, while the remaining differentiated carcinoma cells had the wild-type p53 gene.
  • These findings suggest that the p53 gene mutation is associated with anaplastic transformation of parathyroid carcinoma.
  • [MeSH-major] Carcinoma / pathology. Cell Transformation, Neoplastic / pathology. Genes, p53. Mutation, Missense. Parathyroid Neoplasms / pathology
  • [MeSH-minor] Aged. Cell Nucleus / metabolism. DNA Mutational Analysis. Humans. Hyperparathyroidism / diagnosis. Hyperparathyroidism / etiology. Male. Parathyroidectomy. Polymorphism, Single-Stranded Conformational. Reverse Transcriptase Polymerase Chain Reaction. Treatment Outcome. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19154265.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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30. Lai ML, Faa G, Serra S, Senes G, Daniele GM, Boi F, Mariotti S, Beauchemin M, Asa SL: Rhabdoid tumor of the thyroid gland: a variant of anaplastic carcinoma. Arch Pathol Lab Med; 2005 Mar;129(3):e55-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rhabdoid tumor of the thyroid gland: a variant of anaplastic carcinoma.
  • Scattered follicles with nuclear features of papillary thyroid carcinoma were detected; these cells were immunoreactive for thyroglobulin and TTF-1.
  • The hypothesis that rhabdoid tumor is a variant of anaplastic thyroid carcinoma is supported by the identification of a RET/PTC gene rearrangement, a feature of carcinomas of follicular cell derivation.
  • [MeSH-major] Carcinoma / diagnosis. Rhabdoid Tumor / diagnosis. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 15737050.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Fujiwara K, Shirabe K, Wakiyama S, Oya M, Eguchi T, Akaboshi K, Saitou T: [A case of spindle cell type anaplastic carcinoma of the body of the pancreas]. Nihon Shokakibyo Gakkai Zasshi; 2007 Dec;104(12):1766-71
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  • [Title] [A case of spindle cell type anaplastic carcinoma of the body of the pancreas].
  • We report a resected case of small spindle cell carcinoma of the pancreas, In a Japanese 71-year-old woman with upper abdominal pain, a computed tomography (CT) showed a solid tumor 10 mm in diameter in the body of the pancreas.
  • Although the outcome of spindle cell carcinoma of the pancreas has been reported to be very poor, there may be hope of cure in the patients with small spindle cell carcinoma.
  • [MeSH-major] Carcinoma / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 18057855.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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32. Oktay MH, Smolkin MB, Williams M, Cajigas A: Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma: report of a case of a challenging cytologic diagnosis. Acta Cytol; 2006 Mar-Apr;50(2):201-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic anaplastic carcinoma of the thyroid mimicking squamous cell carcinoma: report of a case of a challenging cytologic diagnosis.
  • BACKGROUND: The probability of anaplastic transformation in a differentiated thyroid carcinoma (DTC) is <2%.
  • Admixture of DTC and undifferentiated carcinoma can occasionally be found in thyroidectomy specimens, or the undifferentiated tumor may develop in metastatic foci months or years after removal of the primary tumor.
  • CASE: Anaplastic transformation of a metastatic DTC was diagnosed at autopsy in a 71-year-old female.
  • At the time of her total thyroidectomy for follicular carcinoma, she already had several lung nodules, which diminished in size upon 131I treatment.
  • Fine needle aspiration biopsy of the paraspinal mass resulted in a diagnosis of metastatic squamous cell carcinoma.
  • Histologic evaluation of the lung nodules and pleura-based mass revealed areas of follicular carcinoma intermixed with a various patterns of undifferentiated carcinoma.
  • The paraspinal and kidney mass consisted entirely of anaplastic tumor, including areas of squamoid differentiation.
  • CONCLUSION: In patients with a history of DTC who develop a rapidly growing mass elsewhere, a possibility of metastatic DTC with anaplastic transformation must be considered.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Kidney Neoplasms / secondary. Lung Neoplasms / secondary. Spinal Neoplasms / secondary. Thyroid Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biopsy, Fine-Needle / methods. Diagnosis, Differential. Disease Progression. Fatal Outcome. Female. Humans. Sensitivity and Specificity


33. Nagy J, Iványi B, Sonkodi I: [Merkel cell carcinoma]. Fogorv Sz; 2006 Aug;99(4):135-9
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  • [Title] [Merkel cell carcinoma].
  • [Transliterated title] Merkel-sejtes carcinoma.
  • Merkel cell carcinoma (Mcc) is a very rare, malignant, neuroendocrine tumour.
  • It was an anaplastic carcinoma with neuroendocrine features, raising the possibility of a late haematogenous metastasis, a second field tumour, or a second primary tumour.
  • [MeSH-major] Carcinoma, Merkel Cell. Facial Neoplasms. Skin Neoplasms. Tonsillar Neoplasms
  • [MeSH-minor] Aged. Aged, 80 and over. Cryosurgery. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Lip

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  • (PMID = 17016920.001).
  • [ISSN] 0015-5314
  • [Journal-full-title] Fogorvosi szemle
  • [ISO-abbreviation] Fogorv Sz
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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34. Kakudo K, Bai Y, Li Y, Wakasa T, Mori I: [Thyroid carcinoma--differentiated, poorly differentiated and anaplastic carcinoma]. Nihon Rinsho; 2007 Nov;65(11):1979-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thyroid carcinoma--differentiated, poorly differentiated and anaplastic carcinoma].
  • The poorly differentiated carcinoma was first added as a new member in the lists of classification of thyroid carcinomas in the WHO 2004 edition.
  • This modification creates a significant change in the incidence and prognosis of this carcinoma.
  • This carcinoma, defined by the new WHO classification, is about 1-5% of all thyroid malignancy and has more aggressive outcome than the previous definition.
  • [MeSH-major] Carcinoma / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18018558.001).
  • [ISSN] 0047-1852
  • [Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine
  • [ISO-abbreviation] Nippon Rinsho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 12
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35. Datta C, Bhattacharyya S, Ghosh A, Ghosh S: Dedifferentiated papillary carcinoma of thyroid in an adolescent girl--a case report. Indian J Pathol Microbiol; 2005 Oct;48(4):496-7
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  • [Title] Dedifferentiated papillary carcinoma of thyroid in an adolescent girl--a case report.
  • Dedifferentiated papillary carcinoma of thyroid shows combined histopathological features of classical papillary carcinoma and anaplastic carcinoma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 16366108.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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36. Ciuni R, Musmeci N, Di Giunta M, Basile F, Ciuni S: [Treatment of microcarcinoma and papillary carcinoma of the thyroid]. Ann Ital Chir; 2010 Mar-Apr;81(2):115-9
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  • [Title] [Treatment of microcarcinoma and papillary carcinoma of the thyroid].
  • [Transliterated title] Trattamento del microcarcinoma e del carcinoma papillifero della tiroide.
  • AIM OF THE STUDY: Of our is to demonstrate that total thyroidectomy with lymphadenectomy of the six level is effective in papillary thyroid carcinomas than for microcarcinoma, according to recent acquisitions on the biological behavior of some microcarcinoma.
  • RESULTS: Of all the interventions of total thyroidectomy, 75% performed for benign disease and 25% for malignant disease (PTMC 356 cases, 291 PTC cases, 56 cases of follicular carcinoma, 5 cases of medullary carcinoma, anaplastic carcinoma, 2 cases).
  • 40% of PTMC underwent TT and subsequent follow up, because the diagnosis was placed postoperatively and in 60% diagnosis was placed during surgery with indication for TT and lymphadenectomy of the sixth level and subsequent follow-up showed no evidence of residual disease or relapse.
  • This applies to papillary carcinomas than for microcarcinoma whose surgical treatment (total thyroidectomy, lobectomy, subtotal thyroidectomy or near-total) is still debated.
  • [MeSH-major] Carcinoma, Papillary / surgery. Lymph Node Excision. Thyroid Neoplasms / surgery. Thyroidectomy

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  • (PMID = 20726389.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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37. Besic N, Hocevar M, Zgajnar J: Lower incidence of anaplastic carcinoma after higher iodination of salt in Slovenia. Thyroid; 2010 Jun;20(6):623-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lower incidence of anaplastic carcinoma after higher iodination of salt in Slovenia.
  • BACKGROUND: Anaplastic thyroid carcinoma (ATC) may arise de novo or from a preexistent differentiated carcinoma.
  • It is well known that higher iodine intake in the diet causes higher frequency of papillary thyroid carcinoma, but decreases the frequency of follicular thyroid carcinoma.
  • [MeSH-major] Carcinoma / epidemiology. Potassium Iodide / administration & dosage. Thyroid Neoplasms / epidemiology

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  • [CommentIn] Thyroid. 2010 Jun;20(6):581-2 [20553193.001]
  • (PMID = 20470204.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Sodium Chloride, Dietary; 1C4QK22F9J / Potassium Iodide
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38. Wang HM, Huang YW, Huang JS, Wang CH, Kok VC, Hung CM, Chen HM, Tzen CY: Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma. Ann Surg Oncol; 2007 Oct;14(10):3011-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma.
  • BACKGROUND: Anaplastic thyroid carcinoma (ATC), a rare and highly malignant tumor, has long been thought to arise from well-differentiated carcinoma (WDC) such as follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC).
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Papillary / genetics. Biomarkers, Tumor / genetics. Carcinoma / genetics. Cell Transformation, Neoplastic / genetics. Neoplasms, Multiple Primary / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 17638058.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Codon; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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39. Wong M, See JY, Sufyan W, Diddapur RK: Splenic infarction. A rare presentation of anaplastic pancreatic carcinoma and a review of the literature. JOP; 2008;9(4):493-8
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  • [Title] Splenic infarction. A rare presentation of anaplastic pancreatic carcinoma and a review of the literature.
  • CONTEXT: Anaplastic carcinoma of the pancreas is a rare variant of ductal adenocarcinoma.
  • CASE REPORT: We report a case of advanced anaplastic carcinoma in a 41-year-old man who presented with splenic infarction.
  • He had a prolonged survival of 16 months from diagnosis.
  • CONCLUSION: Splenic infarction is a most unusual acute presentation of pancreatic carcinoma, which may require emergency tumor resection and splenectomy.
  • [MeSH-major] Abdomen, Acute / etiology. Carcinoma / complications. Carcinoma / pathology. Pancreatic Neoplasms / complications. Pancreatic Neoplasms / pathology. Splenic Infarction / etiology

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  • (PMID = 18648141.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 11
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40. Sato K, Waseda R, Tatsuzawa Y, Soma R, Ueda Y, Katsuda S: Papillary thyroid carcinoma with anaplastic transformation showing a rhabdoid phenotype solely in the cervical lymph node metastasis. Pathol Res Pract; 2006;202(1):55-9
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  • [Title] Papillary thyroid carcinoma with anaplastic transformation showing a rhabdoid phenotype solely in the cervical lymph node metastasis.
  • We describe a rare case of anaplastically transformed papillary thyroid carcinoma with a rhabdoid phenotype appearing solely in a metastatic focus.
  • Examination of surgically resected specimens disclosed that the thyroid tumor was a well-differentiated papillary carcinoma (2.0 cm in diameter), and the right lateral cervical mass was an anaplastic carcinoma (2.4 cm in diameter) showing a rhabdoid phenotype with scant amounts of a papillary carcinoma component in the periphery, considered to be transformed through the metastasis of the papillary thyroid carcinoma in a cervical lymph node.
  • [MeSH-major] Carcinoma, Papillary / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery

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  • (PMID = 16310972.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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41. Lee JW, Yoon DY, Choi CS, Chang SK, Yun EJ, Seo YL, Rho YS, Cho SJ, Kim KH: Anaplastic thyroid carcinoma: computed tomographic differentiation from other thyroid masses. Acta Radiol; 2008 Apr;49(3):321-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic thyroid carcinoma: computed tomographic differentiation from other thyroid masses.
  • BACKGROUND: Anaplastic thyroid carcinoma is rare but is one of the most aggressive malignancies.
  • Therefore, accurate diagnosis is important in order to provide appropriate therapy.
  • PURPOSE: To establish useful computed tomographic (CT) criteria for differentiating anaplastic carcinoma from other thyroid masses.
  • MATERIAL AND METHODS: The CT scans of nine patients with anaplastic carcinomas were retrospectively reviewed and compared with those of 32 patients with papillary carcinomas (n = 12) or benign lesions (n = 20) exceeding a maximum diameter of 2.0 cm.
  • RESULTS: Anaplastic carcinomas appeared as large (average 4.6 cm), solid (100%), and ill-defined (88.9%) masses accompanied by necrosis (100%), nodular calcification (44.4%), direct invasion into the adjacent organs (55.6%), and cervical lymph node involvement (77.8%).
  • Tumor necrosis was the most valuable parameter in differentiating anaplastic carcinomas from other thyroid masses.
  • Patient age (>70 years) and low attenuation value on postcontrast scan (attenuation value <100 HU, or M/m attenuation ratio <1.3) are also helpful predictors for anaplastic carcinoma.
  • CONCLUSION: If a patient is older than 70 years of age and has a large necrotic thyroid mass of low attenuation, anaplastic carcinoma should be included in the differential diagnosis.
  • [MeSH-major] Carcinoma / diagnosis. Thyroid Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Anaplasia / pathology. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Humans. Image Processing, Computer-Assisted / methods. Iohexol. Male. Middle Aged. Radiographic Image Enhancement / methods. Rare Diseases. Reproducibility of Results. Retrospective Studies. Thyroid Gland / radiography

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  • (PMID = 18365821.001).
  • [ISSN] 1600-0455
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol
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42. Chim CS, Ho J, Ooi GC, Choy C, Liang R: Primary anaplastic large cell lymphoma of the pancreas. Leuk Lymphoma; 2005 Mar;46(3):457-9
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  • [Title] Primary anaplastic large cell lymphoma of the pancreas.
  • We presented a patient with primary ALCL of the pancreas masquerading as a carcinoma of the head of pancreas.
  • She was scheduled for a Whipple's operation and the intra-operative frozen section showed anaplastic carcinoma.
  • The proper diagnosis was only derived later with CD30 immunohistochemical study.
  • This carries important implications on the management, as radical surgery is indicated in resectable carcinoma but not for a chemosensitive lymphoma.
  • [MeSH-major] Lymphoma, Large-Cell, Anaplastic / pathology. Pancreatic Neoplasms / pathology


43. Takano T, Ito Y, Hirokawa M, Yoshida H, Miyauchi A: BRAF V600E mutation in anaplastic thyroid carcinomas and their accompanying differentiated carcinomas. Br J Cancer; 2007 May 21;96(10):1549-53
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  • [Title] BRAF V600E mutation in anaplastic thyroid carcinomas and their accompanying differentiated carcinomas.
  • Frequency of a BRAF V600E mutation in anaplastic thyroid carcinoma, which is thought to be derived mainly from papillary carcinoma by multi-step carcinogenesis, is much lower than that in papillary carcinomas.
  • To clarify this phenomenon, we analysed BRAF V600E mutation in 20 cases of anaplastic carcinoma and 13 accompanying differentiated carcinomas.
  • Among twenty cases of anaplastic carcinomas, nine and four accompanied papillary and follicular carcinomas, respectively.
  • BRAF V600E mutation was found in three of nine (33.3%), none of four and one of seven (14.3%) anaplastic carcinomas with papillary carcinoma, follicular carcinoma and without differentiated components, respectively.
  • All three papillary carcinomas accompanied by anaplastic carcinoma with a BRAF V600E mutation were also shown to have a BRAF V600E mutation.
  • In summary, BRAF V600E mutation was occasionally observed in anaplastic carcinomas with papillary carcinoma, and the low frequency of BRAF V600E mutation in anaplastic carcinoma was thought to be due to the low frequency of anaplastic carcinomas with papillary carcinoma.
  • These findings raise a question about the classical model of anaplastic transformation and suggest some roles of thyroid cancer stem cells in the generation of anaplastic carcinoma.
  • [MeSH-major] Carcinoma / genetics. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 17453004.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 3KX376GY7L / Glutamic Acid; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; HG18B9YRS7 / Valine
  • [Other-IDs] NLM/ PMC2359941
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44. Sanada Y, Yoshida K, Itoh M, Okita R, Okada M: Invasive ductal carcinoma of the pancreas showing exophytic growth. Hepatobiliary Pancreat Dis Int; 2009 Feb;8(1):97-102
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  • [Title] Invasive ductal carcinoma of the pancreas showing exophytic growth.
  • BACKGROUND: Invasive pancreatic carcinoma generally appears as poorly defined mass reflecting the infiltrative growth.
  • We aimed to identify the histological and immunohistochemical features in a rare case of pancreatic carcinoma showing exophytic growth.
  • An incorrect preoperative diagnosis was made of solid pseudopapillary tumor of the pancreas.
  • RESULTS: The head of the pancreas contained a well-circumscribed encapsulated mass of 5.0 cm in diameter, comprising 50% adenocarcinoma, with mucinous carcinoma in the center and anaplastic carcinoma at the periphery.
  • The anaplastic carcinoma comprised pleomorphic cells (PCs) and pleomorphic giant cells (PGCs).
  • Immunohistochemistry revealed that the anaplastic carcinoma cells including PGCs were positive for the tumor antigen Mucin 1 and CEA but negative for vimentin.
  • CONCLUSION: Our observations suggest anaplastic carcinoma components in the present tumor have a ductal origin and that the exophytic tumor growth is associated with the phagocytotic activity of PGCs.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 19208524.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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45. Rapkiewicz A, Roses D, Goldenberg A, Levine P, Bannan M, Simsir A: Encapsulated anaplastic thyroid carcinoma transformed from follicular carcinoma: a case report. Acta Cytol; 2009 May-Jun;53(3):332-6
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  • [Title] Encapsulated anaplastic thyroid carcinoma transformed from follicular carcinoma: a case report.
  • BACKGROUND: Anaplastic thyroid carcinoma (ATC) is rare but is one of the most aggressive and lethal human malignancies.
  • Cytologically, ATC has a variable morphologic appearance, including squamoid, giant, spindled and pleomorphic cells.
  • The coexistence of ATC and differentiated or poorly differentiated thyroid carcinoma has been described and usually is diagnosed when the disease is locally advanced.
  • CASE: We describe a case of surgically resectable, encapsulated, well-circumscribed ATC occurring in association with a better differentiated follicular carcinoma diagnosed by fine needle aspiration in a patient exposed to external ionizing radiation.
  • CONCLUSION: Encapsulated variants of anaplastic carcinoma can be seen in association with lower grade thyroid carcinoma such as follicular carcinoma.
  • Accurate diagnosis is dependent on adequate sampling.
  • [MeSH-major] Adenocarcinoma, Follicular / pathology. Carcinoma / secondary. Cell Transformation, Neoplastic. Chernobyl Nuclear Accident. Neoplasms, Radiation-Induced / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 19534279.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Moscetti L, Padalino D, Capomolla E, Nelli F, Pollera CF: A partial response in anaplastic carcinoma of the thyroid with liposomal doxorubicin. J Exp Clin Cancer Res; 2005 Mar;24(1):151-4
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  • [Title] A partial response in anaplastic carcinoma of the thyroid with liposomal doxorubicin.
  • Anaplastic thyroid carcinoma is a rare disease with a poor prognosis.
  • Herein we report the first case of an anaplastic thyroid carcinoma treated with the use of liposomal doxorubicin.

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  • (PMID = 15943045.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Liposomes; 80168379AG / Doxorubicin
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47. Ito Y, Higashiyama T, Hirokawa M, Fukushima M, Inoue H, Yabuta T, Tomoda C, Uruno T, Kihara M, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Miyauchi A: Prognosis of patients with papillary carcinoma showing anaplastic transformation in regional lymph nodes that were curatively resected. Endocr J; 2008 Dec;55(6):985-9
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  • [Title] Prognosis of patients with papillary carcinoma showing anaplastic transformation in regional lymph nodes that were curatively resected.
  • Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis.
  • Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes.
  • We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected.
  • Two of these patients showed anaplastic transformation at the initial surgery and the remaining 3 showed anaplastic transformation after repeated recurrence to the lymph nodes.
  • After resection of anaplastic lesions of the nodes, 2 patients underwent radiation therapy, whereas the remaining 3 did not receive any adjuvant therapy.
  • One patient died of carcinoma 63 months after surgery.
  • It is therefore suggested that long-term survival can be expected for patients with differentiated carcinoma showing anaplastic transformation in the lymph node if the lesions can be curatively resected.
  • [MeSH-major] Carcinoma / secondary. Carcinoma, Papillary / diagnosis. Lymph Nodes / surgery. Thyroid Neoplasms / diagnosis

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  • (PMID = 18612180.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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48. Okamoto M, Kitajima S, Negishi R, Maehata T, Kouro T, Yamauchi S, Takahashi H, Katakura Y, Watanabe Y, Abiko R, Nakaya S, Inaba H, Takano T, Suzuki M, Itoh F: [Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)]. Nihon Shokakibyo Gakkai Zasshi; 2008 Nov;105(11):1656-65
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  • [Title] [Two cases of anaplastic carcinoma of the pancreas in terms of the diversity of carcinoma cells (epithelial-mesenchymal transition; EMT)].
  • A huge tumor mass was observed in the tale of the pancreas, which we diagnosed as pancreatic carcinoma.
  • Pathological findings confirmed that it was anaplastic pancreas carcinoma (giant cell type).
  • Autopsy findings confirmed that it was anaplastic pancreas carcinoma (pleomorphic type).
  • Both cases showed positive for epithelial marker and mesenchymal markers and decrease in stainability by E-cadherin staining, a result which suggested diversity of tumor cells in anaplastic pancreas carcinomas.
  • [MeSH-major] Carcinoma / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18987452.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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49. Khashab MA, Emerson RE, DeWitt JM: Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of anaplastic pancreatic carcinoma: a single-center experience. Pancreas; 2010 Jan;39(1):88-91
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of anaplastic pancreatic carcinoma: a single-center experience.
  • OBJECTIVES: Anaplastic carcinoma of the pancreas (ACP) is an aggressive variant of ductal adenocarcinoma.
  • The aim of this study was to describe a single-center experience with the use of endoscopic ultrasound (EUS) with or without fine-needle aspiration (FNA) for the diagnosis of ACP.
  • METHODS: The cytology and surgical pathology databases were searched for a diagnosis of ACP between 1992 and 2008.
  • The diagnosis of ACP was confirmed after surgical resection in 2 of these 5, including one in whom cytology demonstrated only adenocarcinoma.
  • CONCLUSIONS: Anaplastic carcinoma of the pancreas has variable endosonographic features.
  • Endoscopic ultrasound-FNA may assist in the cytological diagnosis of these tumors.
  • [MeSH-major] Carcinoma / pathology. Pancreas / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy, Fine-Needle / methods. Carcinoma, Pancreatic Ductal / pathology. Diagnosis, Differential. Endosonography. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Survival Analysis

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  • (PMID = 20050229.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Kruk-Zagajewska A, Milecki P, Wierzbicka M: [Advances in the diagnosis of unknown primary carcinoma of the neck]. Otolaryngol Pol; 2005;59(1):77-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Advances in the diagnosis of unknown primary carcinoma of the neck].
  • The diagnosis of carcinoma of unknown primary is set, when histologically the neck metastases are confirmed but the primary focus is not possible to be found or occurs during the follow-up.
  • The squamous cell carcinoma or anaplastic carcinoma recognized in the neck nodes suggest, that the primary focus is localised in the head and neck region.
  • The knowledge of carcinoma cells spreading paths between particular neck regions is crucial for effective diagnostics of tumor localization in upper aerodigestive tract.
  • [MeSH-major] Carcinoma / diagnosis. Head and Neck Neoplasms / diagnosis. Neoplasms, Unknown Primary / diagnosis

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  • (PMID = 15915923.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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51. Abelardo E, Jaramillo M, Sheffield E, Tierney P: Anaplastic thyroid carcinoma implantation after fine needle aspiration cytology. J Laryngol Otol; 2007 Mar;121(3):268-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic thyroid carcinoma implantation after fine needle aspiration cytology.
  • Histopathological studies confirmed anaplastic carcinoma of the thyroid and cutaneous needle track seeding of the primary tumour.
  • The patient succumbed to extensive disease 10 weeks after initial diagnosis.
  • To our knowledge, this is a rare report of implantation of anaplastic thyroid carcinoma along the track of fine needle aspiration.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Carcinoma / pathology. Head and Neck Neoplasms / secondary. Neoplasm Seeding. Skin Neoplasms / secondary. Thyroid Neoplasms / pathology

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  • (PMID = 17040599.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Friedman MV: [Poorly-differentiated thyroid carcinoma: morphological verification and differential diagnosis]. Vopr Onkol; 2006;52(1):47-53
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  • [Title] [Poorly-differentiated thyroid carcinoma: morphological verification and differential diagnosis].
  • Poorly-differentiated thyroid carcinoma is a stage in the development of anaplastic carcinoma from well-differentiated neoplastic transformation of follicular epithelium.
  • [MeSH-major] Carcinoma / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Transformation, Neoplastic / pathology. Child. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Mitotic Index. Neoplasm Invasiveness. Retrospective Studies

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  • (PMID = 16715703.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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53. Hillesheim PB, Farghaly H: Anaplastic spindle cell carcinoma, arising in a background of an ovarian mucinous cystic tumor: a case report with clinical follow up, review of the literature. Int J Clin Exp Pathol; 2010;3(8):808-11
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  • [Title] Anaplastic spindle cell carcinoma, arising in a background of an ovarian mucinous cystic tumor: a case report with clinical follow up, review of the literature.
  • Anaplastic carcinoma (AC) of spindle cell type is an exceedingly rare ovarian malignant neoplasm.
  • To date, there have been less than ten cases of anaplastic spindle cell carcinoma reported in the medical literature.
  • Furthermore, our case is the first time this tumor has been described in a 40-year-old female with malignant spindle cells merging with conventional high grade adeno-carcinoma.
  • The differential diagnosis of spindle cell proliferation in the ovary will be discussed and their distinction using a panel of immunohistochemical stains.
  • [MeSH-major] Carcinoma / pathology. Cystadenocarcinoma, Mucinous / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinosarcoma / diagnosis. Diagnosis, Differential. Endometriosis / diagnosis. Female. Humans. Sarcoma / diagnosis. Treatment Outcome

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  • [Cites] Am J Surg Pathol. 2002 Feb;26(2):139-52 [11812936.001]
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  • (PMID = 21151395.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2993232
  • [Keywords] NOTNLM ; Ovary / anaplastic carcinoma / case report / mucinous neoplasm / spindle cell
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54. Ayhan A, Otegen U, Guven S, Kucukali T: Radical reoperation for invasive cervical cancer found in simple hysterectomy. J Surg Oncol; 2006 Jul 1;94(1):28-34
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  • RESULTS: The mean age at the time of diagnosis was 49.85 (range 38-72).
  • The histopathological diagnoses were SCC, adenocarcinoma, adenosquamous carcinoma, endometroid carcinoma, and anaplastic carcinoma in 70.4%, 11.4%, 7.4%, 7.4%, and 3.7% of patients, respectively.
  • The overall survival rate was 88.89%; it was significantly lower in the presence of the following factors: anaplastic carcinoma, vaginal apex metastasis, and pelvic lymph node metastasis.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Disease-Free Survival. Endometrial Neoplasms / pathology. Endometrial Neoplasms / surgery. Female. Humans. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local / etiology. Neoplasm Staging. Reoperation. Retrospective Studies


55. Wiseman SM, Griffith OL, Deen S, Rajput A, Masoudi H, Gilks B, Goldstein L, Gown A, Jones SJ: Identification of molecular markers altered during transformation of differentiated into anaplastic thyroid carcinoma. Arch Surg; 2007 Aug;142(8):717-27; discussion 727-9
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  • [Title] Identification of molecular markers altered during transformation of differentiated into anaplastic thyroid carcinoma.
  • HYPOTHESIS: A change in tumor expression profile will be observed during the transformation of differentiated into anaplastic thyroid carcinoma.
  • PATIENTS: Sequential archival cases of anaplastic thyroid cancer with an adjacent associated differentiated thyroid cancer focus, and with available paraffin blocks, that had been diagnosed and treated in British Columbia during a 20-year period (12 cases; January 1, 1984, through December 31, 2004) were identified through the provincial tumor registry for tissue microarray construction.
  • MAIN OUTCOME MEASURE: Significant associations between marker staining and tumor pathologic diagnosis (differentiated vs anaplastic) were determined with contingency table and marginal homogeneity tests.
  • RESULTS: Overall, there were 3 up-regulated and 5 down-regulated markers when comparing the anaplastic carcinoma with associated differentiated thyroid cancers.
  • Contingency table statistics identified 5 markers (thyroglobulin, Bcl-2, MIB-1, E-cadherin, and p53) to be significantly differentially expressed by the anaplastic and differentiated tumor foci.
  • Clustering and classification analysis based on these same 8 markers readily separated differentiated and anaplastic thyroid tumors with a high degree of accuracy.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma / pathology. Cell Transformation, Neoplastic / metabolism. Thyroid Neoplasms / pathology

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  • (PMID = 17709725.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 9010-34-8 / Thyroglobulin; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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56. Nakajima A, Takahashi H, Inamori M, Abe Y, Kobayashi N, Kubota K, Yamanaka S: Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report. J Med Case Rep; 2008;2:391

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report.
  • INTRODUCTION: The granulocyte-colony stimulating factor-producing tumor was first reported in 1977, however, anaplastic pleomorphic type carcinoma of the pancreas producing granulocyte-colony stimulating factor is still rare.
  • Based on liver biopsy findings, the tumor was classified as an anaplastic pleomorphic-type carcinoma.
  • Immunohistochemical staining showed that pancreatic carcinoma cells were positive for granulocyte-colony stimulating factor.
  • CONCLUSION: This is a rare case report of anaplastic pleomorphic-type carcinoma of the pancreas producing granulocyte-colony stimulating factor and confirmed by immunohistochemistry.

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  • [Cites] J Clin Gastroenterol. 1998 Dec;27(4):357-60 [9855271.001]
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  • (PMID = 19091098.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2615780
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57. ul Haq RN, Khan BA, Chaudhry IA: Prevalence of malignancy in goitre--a review of 718 thyroidectomies. J Ayub Med Coll Abbottabad; 2009 Oct-Dec;21(4):134-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Prevalence of papillary and follicular carcinoma was 33.33% each.
  • Anaplastic carcinoma was found in 23.81% of patients followed by Hurthle cell carcinoma in 9.53% of patients.
  • Prevalence of follicular carcinoma and anaplastic carcinoma is relatively higher in our country due to high incidence of iodine deficiency goitre.
  • [MeSH-minor] Adolescent. Adult. Carcinoma, Papillary / epidemiology. Carcinoma, Papillary / pathology. Child. Female. Humans. Male. Middle Aged. Pakistan / epidemiology. Prevalence. Prospective Studies. Thyroidectomy. Young Adult

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  • (PMID = 21067046.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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58. Kim YW, Do IG, Park YK: Expression of the GLUT1 glucose transporter, p63 and p53 in thyroid carcinomas. Pathol Res Pract; 2006;202(11):759-65
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  • [Title] Expression of the GLUT1 glucose transporter, p63 and p53 in thyroid carcinomas.
  • Only few studies have evaluated the usefulness of the GLUT1 and p63 status of thyroid carcinomas in revealing tumorigenesis.
  • We studied GLUT1, p53, and p63 immunoexpression in a total of 86 cases of various thyroid carcinoma types to determine the biological significance of GLUT1 and p63 expression in thyroid carcinomas.
  • GLUT1 was detected in six cases of anaplastic carcinoma and in one case of poorly differentiated carcinoma with membranous staining. p63 was detected in five cases of anaplastic carcinoma, in one case of poorly differentiated carcinoma, and in five cases of papillary carcinoma with nuclear positivity. p53 was detected in six cases of anaplastic carcinoma, in one case of poorly differentiated carcinoma, and in one case of follicular carcinoma with nuclear positivity.
  • Five of seven cases of anaplastic carcinoma expressed all three of these markers.
  • The results suggest that GLUT1, p63, and p53 are not expressed in well-differentiated thyroid carcinomas, and that they are usually expressed late in the course of thyroid tumor progression.
  • These data strongly suggest that in anaplastic carcinomas, impairment of p53-mediated repression results in increased GLUT1 and p63 expression, and that this probably reflects the differential regulation of hypoxia-responsive pathways and basal/stem cell regulatory pathways.
  • [MeSH-major] Biomarkers, Tumor / analysis. Glucose Transporter Type 1 / biosynthesis. Membrane Proteins / biosynthesis. Thyroid Neoplasms / metabolism. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 17029809.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Glucose Transporter Type 1; 0 / Membrane Proteins; 0 / SLC2A1 protein, human; 0 / Tumor Suppressor Protein p53
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59. Abrosimov AIu, Dvinskikh NIu, Rotin DL: [Rare thyroid tumors: spindle-cell epithelial tumor and thyroid carcinoma with thymus-like differentiation]. Arkh Patol; 2007 Nov-Dec;69(6):34-7
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  • [Title] [Rare thyroid tumors: spindle-cell epithelial tumor and thyroid carcinoma with thymus-like differentiation].
  • The paper describes 2 cases of spindle-cell epithelial thyroid tumors (SETTLE) and carcinoma showing thymus-like differentiation (CASTLE).
  • They are rare types of thyroid tumors and must be distinguished from medullary carcinoma, anaplastic carcinoma, synovial sarcoma and malignant teratoma.
  • [MeSH-major] Carcinoma / pathology. Thymus Gland / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 18290379.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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60. Aron M, Kapila K, Verma K: Utility of galectin 3 expression in thyroid aspirates as a diagnostic marker in differentiating benign from malignant thyroid neoplasms. Indian J Pathol Microbiol; 2006 Jul;49(3):376-80
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  • The cytology diagnosis of these cases was: papillary carcinoma (25), follicular neoplasm (16), adenomatous goiter (20), hyperplastic nodule (5), medullary carcinoma (5) and anaplastic carcinoma (1).
  • Galectin-3 positivity was seen in 80% of papillary carcinomas, 37.5% offollicular neoplasms and in 60% of benign nodules.
  • The single case of anaplastic carcinoma was positive but all the cases of medullary carcinoma were negativefor galectin-3.
  • Three of thefollicular neoplasms that were diagnosed on histology as carcinoma were positive on cytology and one case offollicular adenoma was also positive.
  • Our study shows that galectin-3 is strongly expressed in smears of papillary carcinoma.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Biomarkers, Tumor / metabolism. Carcinoma / metabolism. Carcinoma / pathology. Galectin 3 / metabolism. Thyroid Gland / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Academies and Institutes. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Hyperplasia / metabolism. Immunohistochemistry. India. Male. Middle Aged. Prospective Studies

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  • (PMID = 17001889.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Galectin 3
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61. Nix PA, Nicolaides A, Coatesworth AP: Thyroid cancer review 3: management of medullary and undifferentiated thyroid cancer. Int J Clin Pract; 2006 Jan;60(1):80-4
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  • Over 90% of thyroid cancer is of the differentiated type associated with a very good 10-year disease-free survival rate.
  • In contrast, the rare forms of thyroid cancer which comprise medullary thyroid cancer arising from parafollicluar C cells, Hurthle cell carcinoma, anaplastic carcinoma, thyroid lymphoma and squamous cell carcinoma are typically associated with a poorer survival rate.
  • [MeSH-major] Carcinoma / therapy. Thyroid Neoplasms / therapy
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Humans. Lymphoma / diagnosis. Neoplasm Staging / methods

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  • (PMID = 16409432.001).
  • [ISSN] 1368-5031
  • [Journal-full-title] International journal of clinical practice
  • [ISO-abbreviation] Int. J. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 37
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62. Landriscina M, Fabiano A, Altamura S, Bagalà C, Piscazzi A, Cassano A, Spadafora C, Giorgino F, Barone C, Cignarelli M: Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma. J Clin Endocrinol Metab; 2005 Oct;90(10):5663-71
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  • [Title] Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma.
  • OBJECTIVES: Aggressive biological behavior and loss of specific thyroid cell functions, such as thyroglobulin, thyroid peroxidase, TSH receptor, Na/I symporter expression, and iodine uptake are features of anaplastic thyroid cancer.
  • RESULTS: Our findings showed that nevirapine and efavirenz reversibly inhibit cell proliferation without triggering cell death in the undifferentiated thyroid carcinoma ARO and FRO cells, which exhibited high levels of endogenous RT activity.
  • CONCLUSIONS: These findings support the need for clinical trials to clarify whether RT inhibitors may restore the sensitivity to radiometabolic therapy in anaplastic thyroid tumors.
  • [MeSH-major] Carcinoma / metabolism. Carcinoma / physiopathology. Cell Proliferation / drug effects. Iodine / metabolism. Reverse Transcriptase Inhibitors / pharmacology. Signal Transduction / drug effects. Thyroid Neoplasms / metabolism. Thyroid Neoplasms / physiopathology. Thyrotropin / physiology

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  • (PMID = 16030158.001).
  • [ISSN] 0021-972X
  • [Journal-full-title] The Journal of clinical endocrinology and metabolism
  • [ISO-abbreviation] J. Clin. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Thyrotropin; 0 / Reverse Transcriptase Inhibitors; 9002-71-5 / Thyrotropin; 9679TC07X4 / Iodine; EC 2.7.7.49 / RNA-Directed DNA Polymerase
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63. Baloch ZW, LiVolsi VA: Unusual tumors of the thyroid gland. Endocrinol Metab Clin North Am; 2008 Jun;37(2):297-310, vii
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  • These include follicular adenoma and carcinoma (Hürthle and non-Hürthle), and papillary carcinoma and its variants.
  • Other primary epithelial tumors include medullary carcinoma, mixed medullary and follicular carcinomas, insular and poorly differentiated carcinoma, anaplastic carcinoma, and the least common squamous carcinoma and related tumors.
  • In this article, the authors review the unusual tumors of the thyroid, their morphologic features, and clinical and prognostic implications.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma / pathology. Rare Diseases / diagnosis. Rare Diseases / pathology. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / pathology. Disease Progression. Humans. Neoplasm Staging. Prognosis. Thyroid Gland / pathology

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  • (PMID = 18502328.001).
  • [ISSN] 0889-8529
  • [Journal-full-title] Endocrinology and metabolism clinics of North America
  • [ISO-abbreviation] Endocrinol. Metab. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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64. Sykorova V, Dvorakova S, Ryska A, Vcelak J, Vaclavikova E, Laco J, Kodetova D, Kodet R, Cibula A, Duskova J, Hlobilkova A, Astl J, Vesely D, Betka J, Hoch J, Smutny S, Cap J, Vlcek P, Novak Z, Bendlova B: BRAFV600E mutation in the pathogenesis of a large series of papillary thyroid carcinoma in Czech Republic. J Endocrinol Invest; 2010 May;33(5):318-24
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  • [Title] BRAFV600E mutation in the pathogenesis of a large series of papillary thyroid carcinoma in Czech Republic.
  • BACKGROUND: Activating point mutation of the BRAF gene, the most common genetic alteration reported in papillary thyroid carcinomas (PTC), has been associated with poor prognostic characteristics.
  • SUBJECTS AND METHODS: DNAs were extracted from 242 PTCs, 23 sporadic medullary carcinomas, one anaplastic carcinoma and 6 poorly differentiated carcinomas.
  • RESULTS: BRAFV600E mutation was detected in 81 of 242 PTCs (33.5%), in one of 6 poorly differentiated carcinomas (16.7%) and in anaplastic carcinoma.
  • The mutation correlated with a higher age at diagnosis (p=0.049) and with a greater tumor size (p=0.041).
  • [MeSH-major] Carcinoma, Papillary / genetics. Proto-Oncogene Proteins B-raf / genetics. Thyroid Neoplasms / genetics

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  • (PMID = 20009493.001).
  • [ISSN] 1720-8386
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Codon; 0 / DNA, Neoplasm; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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65. Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, Matsuzuka F, Kakudo K, Kuma K, Miyauchi A: Expression of S100A2 and S100A6 in thyroid carcinomas. Histopathology; 2005 May;46(5):569-75
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  • [Title] Expression of S100A2 and S100A6 in thyroid carcinomas.
  • AIMS: S100 calcium-binding proteins are known to play multiple roles in carcinoma development.
  • Although 89.5% of papillary carcinoma were positive for S100A2, the expression was heterogeneous except in two cases.
  • In anaplastic carcinoma, 78.5% of cases expressed S100A2 diffusely, while the remaining cases were negative.
  • In normal follicles, S100A6 expression was always low, while 8.3% of follicular adenomas and 39.5% of follicular carcinomas showed increased expression.
  • In papillary carcinomas, S100A6 expression was increased in 75% of cases, but in anaplastic carcinomas it was decreased, with only 14.3% showing high expression.
  • CONCLUSIONS: The expression patterns of S100A2 and S100A6 in thyroid neoplasms are unique compared with those of other carcinomas, suggesting that: (i) S100A2 and S100A6 contribute to certain events in papillary carcinoma progression, and (ii) S100A2 expression is one of the biological characteristics of anaplastic carcinoma.
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Humans. Immunohistochemistry

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  • (PMID = 15842639.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Chemotactic Factors; 0 / S100 Proteins; 0 / S100A2 protein, human; 105504-00-5 / S100A6 protein, human
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66. Hirokawa M, Haba R, Kushida Y, Bando K, Kuma S, Kihara M, Miyauchi A: Benign nodular goiter with spindle cell component. Pathol Int; 2010 Aug;60(8):586-90
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  • We thought that the spindle cells are derived from follicular cell and non-neoplastic, and it is important to recognize this lesion to distinguish from aggressive and lethal components seen in papillary carcinoma or anaplastic carcinoma.
  • [MeSH-major] Carcinoma, Papillary / pathology. Goiter, Nodular / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 20618737.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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67. Olthof M, Persoon AC, Plukker JT, van der Wal JE, Links TP: Anaplastic thyroid carcinoma with rhabdomyoblastic differentiation: a case report with a good clinical outcome. Endocr Pathol; 2008;19(1):62-5
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  • [Title] Anaplastic thyroid carcinoma with rhabdomyoblastic differentiation: a case report with a good clinical outcome.
  • Anaplastic thyroid carcinoma is a rare and highly malignant disease.
  • Usually, this type of tumor is irresectable, and almost all patients die within 1 year after diagnosis.
  • We present a case of anaplastic thyroid carcinoma with rhabdomyoblastic differentiation and good therapeutic outcome.
  • Biopsy of the mass showed microscopically and immunohistochemically a follicular (Hürthle cell) carcinoma of the thyroid, dedifferentiated to an anaplastic carcinoma with divergent differentiation along rhabdomyoblastic cell lines.
  • Other cases of rhabdomyoblastic and rhabdoid anaplastic thyroid carcinomas have been described.
  • Both types of carcinoma are associated with an aggressive clinical course.
  • The good clinical outcome of our patient suggests that surgical resection, radiotherapy, and I-131 ablation therapy with curative intent seems to be an adequate treatment option in patients with anaplastic thyroid carcinoma with rhabdoid and rhabdomyoblastic differentiation.
  • [MeSH-major] Carcinoma / pathology. Rhabdomyosarcoma / pathology. Thyroid Neoplasms / pathology. Thyroidectomy

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  • (PMID = 18330722.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 9010-34-8 / Thyroglobulin
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68. Taccaliti A, Boscaro M: Genetic mutations in thyroid carcinoma. Minerva Endocrinol; 2009 Mar;34(1):11-28
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  • [Title] Genetic mutations in thyroid carcinoma.
  • Thyroid carcinoma is the most common endocrine neoplasm and the seventh most frequent human malignancy.
  • Differentiated tumors include those arising from thyrocytes, i.e. papillary and follicular carcinoma, while medullary carcinoma originates from parafollicular or C cells.
  • Anaplastic carcinoma comprises undifferentiated tumors.
  • The factors inducing thyroid carcinoma development are not fully understood despite some well-established associations, such as the one between ionizing radiation and papillary carcinoma and that between iodine deficiency and follicular carcinoma.
  • Genetic investigations of differentiated thyroid tumors have documented mutation of genes involved in the regulation of MAP kinase pathway activation in papillary carcinoma, and of genes involved in the regulation of the PI3 kinase pathway in follicular carcinoma.
  • Analysis of their clinical course and of positivity for mutations has demonstrated that prognosis is greatly affected by the type of mutated gene.
  • Genetic investigations therefore have the potential to direct diagnosis, but especially to tailor therapy and follow-up to the individual patient and even the individual gene.
  • Anaplastic carcinoma, a highly aggressive, undifferentiated form, can arise as such or else be the de-differentiated progression of a papillary or a follicular carcinoma.
  • Medullary carcinoma is a malignant neoplasm with an intermediate clinical course between differentiated and undifferentiated forms.
  • Identification of the gene responsible for medullary carcinoma has radically changed the diagnostic approach to the familial forms, enabling early neonatal diagnosis of mutation carriers and of the disease, and early surgical approach by prophylactic thyroidectomy.
  • Genetic studies have significantly affected the endocrinologist's diagnostic approach, as in the case of medullary carcinoma; over the next few years they are expected to provide further information to tackle papillary and follicular thyroid carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Carcinoma, Papillary / genetics. DNA, Neoplasm / genetics. Mutation. Oncogenes. Thyroid Neoplasms / genetics

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  • (PMID = 19209125.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Oncogene Proteins, Fusion
  • [Number-of-references] 180
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69. Muto H, Yamagata K, Inoue M, Nakazawa K, Hashimoto Y, Matsunaga T, Hirayama K, Hattori K, Akaza H, Koyama A: Acute multifocal bacterial nephritis complicated with acute renal failure and thrombocytopenia. Intern Med; 2005 Oct;44(10):1084-7

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  • Due to rapid enlargement of the kidney, we first suspected that she had diffuse renal invasion of anaplastic carcinoma or lymphoma of the kidney.
  • We finally made a diagnosis of acute multifocal bacterial nephritis.

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  • (PMID = 16293922.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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70. Santeusanio G, Schiaroli S, Ortenzi A, Mulè A, Perrone G, Fadda G: Solitary fibrous tumour of thyroid: report of two cases with immunohistochemical features and literature review. Head Neck Pathol; 2008 Sep;2(3):231-5
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  • The differential diagnosis of thyroid SFT includes different types of spindle cell proliferation, benign and malignant mesenchymal tumours, medullary thyroid carcinoma, fasciitis-like papillary carcinoma, and undifferentiated (anaplastic) carcinoma.
  • However, the morphologic and immunohistochemical findings of SFT are so characteristic that this diagnosis seldom represent a difficulty.
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Carcinoma / diagnosis. Carcinoma, Medullary / diagnosis. Carcinoma, Papillary / diagnosis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Mesenchymoma / diagnosis. Middle Aged

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  • (PMID = 20614321.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807559
  • [Keywords] NOTNLM ; Immunohistochemistry / Review / Solitary fibrous tumour / Thyroid
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71. Saqi A, Livolsi V, Mandel SJ, Baloch Z: Cervical chordoma masquerading as a thyroid neoplasm: a case report. Diagn Cytopathol; 2005 May;32(5):296-8
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  • We report a case of a paraspinal mass juxtaposed adjacent to the thyroid with intranuclear inclusions of papillary carcinoma, abundant eosinophilic cytoplasm of an oncocytic lesion, and pleomorphism of anaplastic carcinoma that expressed thyroglobulin and emulated a malignant thyroid neoplasm.
  • This case highlights the significance of including chordoma in the differential diagnosis of a thyroid neoplasm and interpreting thyroglobulin reactivity warily, because its inadvertent tracking during fine-needle aspirates (FNAs) can produce false positive staining of nonthyroidal cells.
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Intranuclear Inclusion Bodies / pathology. Neck. Neoplasm Invasiveness / pathology. Thyroglobulin / metabolism. Thyroidectomy. Treatment Outcome

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15830368.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9010-34-8 / Thyroglobulin
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72. Sugimoto S, Doihara H, Ogasawara Y, Aoe M, Sano S, Shimizu N: Intraatrial extension of thyroid cancer: a case report. Acta Med Okayama; 2006 Apr;60(2):135-40
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  • A 61-year-old man, who was diagnosed with superior vena cava syndrome by papillary thyroid carcinoma, was referred to our hospital.
  • A histological diagnosis of anaplastic carcinoma arising from transformation of papillary carcinoma was made.
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Cardiopulmonary Bypass. Heart Atria / pathology. Humans. Male. Middle Aged. Syndrome. Tracheal Neoplasms / secondary. Tracheal Neoplasms / surgery. Vascular Neoplasms / secondary. Vascular Neoplasms / surgery. Vena Cava, Superior / pathology

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  • (PMID = 16680191.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 9
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73. King AD, Yeung DK, Ahuja AT, Tse GM, Chan AB, Lam SS, van Hasselt AC: In vivo 1H MR spectroscopy of thyroid carcinoma. Eur J Radiol; 2005 Apr;54(1):112-7
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  • [Title] In vivo 1H MR spectroscopy of thyroid carcinoma.
  • To determine if proton magnetic resonance spectroscopy (1H MRS) of thyroid carcinoma is feasible and to determine if 1H MRS spectra of malignant tumors differ from that of normal thyroid tissue.
  • Spectra acquired from six primary tumors (three anaplastic carcinomas, two papillary carcinomas and one follicular carcinoma) and two nodes (two papillary carcinoma metastases) were analyzed in the time-domain using a non-linear least squares fitting algorithm with incorporation of prior knowledge.
  • Choline (3.2 ppm) was identified in all solid carcinomas with a mean choline/creatine of 4.3 at TE 136 ms and 5.4 at TE 272 ms.
  • Ratios for malignant tumors at TE 136 ms ranged from 1.6 in well differentiated follicular carcinoma to 9.4 in anaplastic carcinoma.
  • [MeSH-major] Carcinoma / diagnosis. Magnetic Resonance Spectroscopy / methods. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Algorithms. Choline / metabolism. Creatine / metabolism. Diagnosis, Differential. Female. Humans. Least-Squares Analysis. Male. Middle Aged

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  • (PMID = 15797300.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] MU72812GK0 / Creatine; N91BDP6H0X / Choline
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74. Green LD, Mack L, Pasieka JL: Anaplastic thyroid cancer and primary thyroid lymphoma: a review of these rare thyroid malignancies. J Surg Oncol; 2006 Dec 15;94(8):725-36
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  • [Title] Anaplastic thyroid cancer and primary thyroid lymphoma: a review of these rare thyroid malignancies.
  • BACKGROUND: To review the current literature on the treatment of anaplastic thyroid cancer (ATC) and thyroid lymphoma (TL).
  • RESULTS: Both anaplastic carcinoma (ATC) and TL represent rare forms of thyroid cancer.
  • DISCUSSION: Although both ATC and TL are rare, it is important for surgeons to be aware of the need for multimodality therapy when treating these patients and to understand the limited role surgery plays in diagnosis and treatment.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma. Lymphoma. Thyroid Neoplasms. Thyroidectomy


75. Jandousová E, Gladis P, Stetka P, Krpenský A, Korsa M: [Urgent thyroidectomy for a mechanical syndrome caused by a toxic nodular goiter--a case report]. Rozhl Chir; 2010 Aug;89(8):498-500

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  • Acutely onset mechanical syndrome during hospitalization of the patient in another department for a different diagnosis (vertebrogenic algic syndrome of Th-L spine) warranted acute intubation and mechanical ventilation.
  • All published cases of acute compression syndrome with respiratory insufficiency involve anaplastic carcinoma transformation, fast growing lymphoma, injuries with an intraglandular haemorrhage or infected cysts.

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  • (PMID = 21121144.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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76. Kim HS, Kim GY, Lim SJ, Kim YW: Raf-1 kinase inhibitory protein expression in thyroid carcinomas. Endocr Pathol; 2010 Dec;21(4):253-7
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  • [Title] Raf-1 kinase inhibitory protein expression in thyroid carcinomas.
  • RKIP is reduced in a variety of human carcinomas, but RKIP expression in thyroid carcinomas has not been analyzed at the protein level.
  • In this study, we examined the immunohistochemical expression of RKIP in various subtypes of thyroid carcinoma.
  • Immunostaining for RKIP was performed on 104 cases of primary thyroid carcinoma (40 papillary, 29 follicular, 11 medullary, 11 poorly differentiated, and 13 anaplastic carcinomas) and 26 cases of nodal metastatic tumor (17 papillary, 4 medullary, and 5 anaplastic carcinomas).
  • Normal thyroid tissue and all cases of follicular, papillary, and medullary carcinomas showed uniform, strong cytoplasmic immunoreactivity for RKIP.
  • With the exception of one case, poorly differentiated carcinomas also revealed strong RKIP expression.
  • In contrast, RKIP expression was completely absent in all anaplastic carcinomas.
  • The transition zone from the differentiated carcinoma component (strong RKIP expression) to the anaplastic carcinoma component (no RKIP expression) demonstrated a completely opposite pattern of RKIP immunoreactivity.
  • This reduction of RKIP expression in anaplastic carcinoma was statistically significant (P < 0.0001).
  • Additionally, RKIP expression of nodal metastatic tumors corresponded with that of primary tumors: metastatic papillary and medullary carcinomas showed uniform, strong cytoplasmic RKIP immunoreactivity, in contrast, in metastatic anaplastic carcinomas, RKIP expression was completely absent.
  • RKIP expression is significantly reduced in anaplastic thyroid carcinoma as compared to other subtypes of thyroid carcinoma.
  • Further studies are necessary to elucidate the precise mechanism of RKIP action in anaplastic thyroid carcinoma.
  • [MeSH-minor] Adenocarcinoma, Follicular / metabolism. Adenocarcinoma, Follicular / pathology. Adolescent. Adult. Aged. Carcinoma / metabolism. Carcinoma / pathology. Carcinoma, Medullary / metabolism. Carcinoma, Medullary / pathology. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Child. Female. Humans. Immunohistochemistry. Male. Middle Aged. Young Adult

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  • (PMID = 20734161.001).
  • [ISSN] 1559-0097
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / PEBP1 protein, human; 0 / Phosphatidylethanolamine Binding Protein
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77. Menon MP, Khan A: Micro-RNAs in thyroid neoplasms: molecular, diagnostic and therapeutic implications. J Clin Pathol; 2009 Nov;62(11):978-85
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  • Thyroid carcinomas encompass a wide spectrum ranging from well-differentiated thyroid carcinomas to poorly differentiated and anaplastic carcinoma.
  • Currently, a considerable degree of interobserver variability exists in the morphological diagnosis of certain types of thyroid carcinomas especially the follicular pattern neoplasm.
  • The prediction of progression of these differentiated carcinoma to more aggressive forms like poorly differentiated and anaplastic types is of considerable interest to physicians and pathologists for determining prognosis and making therapeutic decisions.
  • Several investigators have proposed a more cohesive approach to thyroid cancer diagnosis incorporating molecular and proteomics based tools in addition to the conventional morphological diagnosis.
  • In this context, miRNAs serve as an important diagnostic tool, and several studies have demonstrated their utility as class identifiers especially in the context of follicular thyroid carcinoma, papillary thyroid carcinoma and anaplastic thyroid carcinoma.
  • [MeSH-minor] Adenocarcinoma, Follicular / diagnosis. Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / genetics. Adenoma / diagnosis. Adenoma / genetics. Carcinoma / diagnosis. Carcinoma / genetics. Cell Differentiation / genetics. Diagnosis, Differential. Disease Progression. Gene Expression Regulation, Neoplastic / genetics. Humans. Prognosis

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  • (PMID = 19625289.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Neoplasm
  • [Number-of-references] 93
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78. Ricciardelli L, Rapicano G, Pinto A, Napolitano G, Feleppa C, Martino G, Martino A: [Small bowel intussusception caused by metastasis from anaplastic thyroid carcinoma: case report and literature review]. Ann Ital Chir; 2006 Jan-Feb;77(1):63-7
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  • [Title] [Small bowel intussusception caused by metastasis from anaplastic thyroid carcinoma: case report and literature review].
  • [Transliterated title] Invaginazione ileo-ileale da metastasi di carcinoma anaplastico tiroideo. Caso clinico e revisione della letteratura.
  • The Authors report a case of anaplastic thyroid carcinoma with lung metastasis, brain metastasis and an isolated metastasis to the small bowel leading intestinal obstruction due to small bowel intussusception.
  • The Authors review the international literature about frequency, etiopathogenesis, clinical and diagnostic features and therapy of small bowel metastasis by extra-abdominal malignancies, especially by primary anaplastic thyroid carcinoma.
  • Small bowel metastasis from extra-abdominal malignancies are very unusual, especially from anaplastic thyroid carcinoma, and the etiopathogenesis is still unknown.
  • Clinical findings are typical for abdominal urgency, especially by small bowel obstruction from anaplastic thyroid carcinoma.
  • Computed Tomography has an important role in detecting the type of intestinal obstruction despite it is often unable to diagnose an isolated metastasis.
  • [MeSH-major] Carcinoma / complications. Carcinoma / diagnosis. Ileal Neoplasms / complications. Ileal Neoplasms / diagnosis. Intussusception / etiology. Thyroid Neoplasms / pathology

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  • (PMID = 16910363.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 37
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79. Westhoff CC, Karakas E, Dietz C, Barth PJ: Intrathyroidal hematopoiesis: a rare histological finding in an otherwise healthy patient and review of the literature. Langenbecks Arch Surg; 2008 Sep;393(5):745-9

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  • It also represents an important differential diagnosis of anaplastic carcinoma of the thyroid, particularly in intra-operative frozen sections and fine-needle aspiration biopsy.

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  • (PMID = 18299884.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 15
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80. Tabrizi AD, Kalloger SE, Köbel M, Cipollone J, Roskelley CD, Mehl E, Gilks CB: Primary ovarian mucinous carcinoma of intestinal type: significance of pattern of invasion and immunohistochemical expression profile in a series of 31 cases. Int J Gynecol Pathol; 2010 Mar;29(2):99-107
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  • [Title] Primary ovarian mucinous carcinoma of intestinal type: significance of pattern of invasion and immunohistochemical expression profile in a series of 31 cases.
  • Primary ovarian mucinous carcinomas of the intestinal type are uncommon and earlier reports have included cases diagnosed according to older, less stringent, criteria (which would now be considered borderline tumors) and variable numbers of cases of metastatic adenocarcinoma.
  • This study was conducted to identify all cases of primary mucinous carcinoma of the ovary in a population-based registry, diagnosed according to WHO 2003 criteria, and to characterize their histologic features, immunohistochemical expression profile, and outcome.
  • Thirty-one cases of primary ovarian mucinous carcinoma were included in this study.
  • Twenty-six of 31 (83.9%) tumors had expansile stromal invasion, 4 of 31 (12.9%) showed destructive invasion, and 1 of 31 (3.2%) had anaplastic carcinoma in a mural nodule.
  • At follow-up, 6 of 26 patients (23.1%) with tumors showing expansile invasion experienced a recurrence, compared with 1 of 4 patients (25%) with destructive invasion and the single patient (100%) with anaplastic carcinoma.
  • Our findings support current diagnostic criteria for primary ovarian mucinous carcinoma, that is, the presence of expansile invasion, in the absence of destructive invasion, warrants a diagnosis of carcinoma.
  • A large majority of mucinous carcinomas show only an expansile pattern of invasion and are confined to the pelvis at diagnosis.

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  • (PMID = 20173494.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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81. Schmid KW: [Problem areas of tumour classifications--thyroid carcinomas]. Verh Dtsch Ges Pathol; 2007;91:57-65
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  • [Title] [Problem areas of tumour classifications--thyroid carcinomas].
  • Thyroid carcinoma has been traditionally subdivided into the four major groups papillary, follicular, medullary, and anaplastic carcinoma.
  • The WHO classification of thyroid tumours, published in 2004, has added to these four tumour groups the entity of poorly differentiated carcinoma as well as a broad variety of rare thyroid malignancies.
  • Another important change concerns the histological hallmarks of papillary carcinoma, the diagnosis of which is now exclusively dependent on characteristic nuclear features.
  • The aim of the present paper is to highlight diagnostic problems particularly caused by the alteration introduced onto the WHO classification, This includes a proposal of a more systematic thyroid carcinoma classification based on the histogenetic differentiation (follicular cell differentiation.
  • C cell differentiation, rare carcinomas) and tumour grading of carcinomas with follicular cell differentiation (differentiated, poorly differentiated and anaplastic carcinomas) as well as commentaries on the diagnosis of papillary carcinoma, poorly differentiated carcinoma, and rare types of thyroid carcinoma (squamous cell carcinoma, mucoepidermoid carcinoma, sclerosing mucoepidermoid carcinoma with eosinophilia, mucinous carcinoma, SETTLE, and CASTLE).
  • [MeSH-major] Carcinoma / classification. Thyroid Neoplasms / classification
  • [MeSH-minor] Carcinoma, Papillary / classification. Carcinoma, Papillary / pathology. Humans. World Health Organization

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  • (PMID = 18314596.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 37
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82. Hunt JL: Unusual thyroid tumors: a review of pathologic and molecular diagnosis. Expert Rev Mol Diagn; 2005 Sep;5(5):725-34
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  • [Title] Unusual thyroid tumors: a review of pathologic and molecular diagnosis.
  • The most common thyroid neoplasms are either follicular derived (papillary, follicular and Hürthle cell lesions) or C-cell derived (medullary carcinoma).
  • The diagnosis of these tumors can usually be made at the histologic level, with immunohistochemical stains necessary in some circumstances.
  • These less common thyroid tumors include tall cell and cribriform-morular variants of papillary carcinoma, hyalinizing trabecular tumor, mucoepidermoid and sclerosing mucoepidermoid carcinoma with eosinophilia, poorly differentiated (insular) carcinoma, and undifferentiated (anaplastic) carcinoma.
  • [MeSH-major] Molecular Diagnostic Techniques. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Cell Differentiation. Humans

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  • (PMID = 16149875.001).
  • [ISSN] 1744-8352
  • [Journal-full-title] Expert review of molecular diagnostics
  • [ISO-abbreviation] Expert Rev. Mol. Diagn.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 116
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83. Shikama Y, Mizukami H, Sakai T, Yagihashi N, Okamoto K, Yagihashi S: Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis. J Endocrinol Invest; 2006 Feb;29(2):168-71
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  • [Title] Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis.
  • Spindle cell metaplasia in thyroid adenoma or carcinoma is rare and its pathological features are not well characterized.
  • Distinction of this entity from medullary or anaplastic carcinoma has an important clinical implication.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Metaplasia / pathology. Middle Aged

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  • (PMID = 16610245.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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84. De Padua M, Kaul S, Sarin R, Kaul S, Das PK: Primary lymphoma of the breast: a clinicopathological study. Indian J Pathol Microbiol; 2007 Oct;50(4):722-5
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  • All were diffuse large B cell type.
  • Application of immunohistochemistry greatly aids in differentiating lymphoma from anaplastic carcinoma, with which it can easily be confused.
  • Preoperative diagnosis on a trucut biopsy is an ideal diagnostic method since diagnosis on fine needle aspiration cytology or frozen section may not be possible.
  • Accurate diagnosis is essential, so that appropriate treatment may be applied.
  • [MeSH-major] Breast Neoplasms / pathology. Hodgkin Disease / complications. Lymphoma / diagnosis. Lymphoma / pathology
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols. Carcinoma / diagnosis. Carcinoma / pathology. Cyclophosphamide. Diagnosis, Differential. Doxorubicin. Female. Humans. Middle Aged. Prednisolone. Vincristine

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  • (PMID = 18306536.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; VAP-cyclo protocol
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85. Shindo G, Endo T, Onda M, Shimada T, Inou T, Hiruta H: [Pulmonary large cell carcinoma contiguous to bullae with massive bullous hematoma and hemoptysis; with special reference to 20 cases of Japanese reports]. Kyobu Geka; 2005 Aug;58(9):787-93
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  • [Title] [Pulmonary large cell carcinoma contiguous to bullae with massive bullous hematoma and hemoptysis; with special reference to 20 cases of Japanese reports].
  • Pathological examination, however, revealed anaplastic carcinoma inside bulla of S(1+2)c with minimal invasion into adhered parietal pleura (p 3).
  • The final pathological diagnosis was large cell carcinoma of left S(1+2)c with the staging pT3N0M0 and stage II.
  • Clinical analysis of Japanese 20 cases of lung carcinoma with initial signs of hemosputa and/or hemoptysis contiguous to emphysematous bullae elucidate following important facts.
  • Hemosputa and hemoptysis play important role for early finding and diagnosis of lung cancer contiguous to bullous disease, especially in patients of early clinical stage with or without computed tomography (CT) exams and promise to better surgical prognosis and survivals as compared with non hemosputa ones.
  • [MeSH-major] Blister / surgery. Carcinoma, Large Cell / diagnosis. Hematoma / surgery. Lung Diseases / surgery. Lung Neoplasms / diagnosis. Pneumonectomy

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  • (PMID = 16104563.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 25
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86. Braunschweig T, Kaserer K, Chung JY, Bilke S, Krizman D, Knezevic V, Hewitt SM: Proteomic expression profiling of thyroid neoplasms. Proteomics Clin Appl; 2007 Mar;1(3):264-71
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  • Differentiating benign neoplasms such as follicular adenomas from malignant entities such as follicular carcinomas and papillary carcinoma can be challenging.
  • To define the proteomic profile of different thyroid tumors, we screened an antibody array of 330 features against five thyroid neoplasms: follicular adenoma, follicular carcinoma, papillary carcinoma, anaplastic carcinoma, and medullary carcinoma as well as normal thyroid epithelium.
  • Analysis revealed c-erbB-2, Annexin IV, and Stat5a have potential clinical utility to differentiate follicular adenoma, follicular carcinoma, and papillary carcinoma from each other.
  • By using an antibody array as a discovery platform and a tissue microarray as a first step in validation on a large number of specimens, we have identified new markers that have potential utility in the diagnosis of thyroid neoplasms.

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  • [Copyright] Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
  • (PMID = 21136677.001).
  • [ISSN] 1862-8346
  • [Journal-full-title] Proteomics. Clinical applications
  • [ISO-abbreviation] Proteomics Clin Appl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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87. Bakar B, Tekkök IH: Primary undifferentiated ovarian carcinoma diagnosed by its metastasis to brain: an unusual case report. Turk Neurosurg; 2008 Oct;18(4):431-5
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  • [Title] Primary undifferentiated ovarian carcinoma diagnosed by its metastasis to brain: an unusual case report.
  • OBJECTIVES: Intracranial metastasis of ovarian tumours is rarely seen with an incidence 0.1- 5% but simultaneous diagnosis of primary undifferentiated carcinoma of the ovary and its CNS metastasis has not been published previously.
  • The histopathological diagnosis was undifferentiated ovarian carcinoma which dedifferentiated from endometrioid-type ovarian adenocarcinoma.
  • A week after gynecologic surgery, the patient underwent surgery for a left occipital tumour which proved to be anaplastic carcinoma metastasis.
  • The patient succumbed 15 months after the diagnosis.
  • CONCLUSIONS: Although metastasis from undifferentiated ovarian carcinomas to the central nervous system have been published with the CNS disease often developing long after the initial diagnosis of primary tumour; simultaneous diagnosis of primary undifferentiated carcinoma of the ovary and its CNS metastasis as described in our case may rarely occur.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / secondary. Carcinoma / diagnosis. Carcinoma / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / pathology

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  • (PMID = 19107695.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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88. Mehdi G, Ansari HA, Siddiqui SA: Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast-like giant cells--a case report. Diagn Cytopathol; 2007 Feb;35(2):111-2
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  • [Title] Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast-like giant cells--a case report.
  • Anaplastic carcinoma of the thyroid is known for its highly aggressive behaviour and rapid spread.
  • While the giant cell variant is a well recognized morphologic pattern, the presence of osteoclast-like giant cells is a rare occurrence.
  • We report a case of anaplastic carcinoma of the thyroid with focal presence of osteoclast-like giant cells occurring in an elderly male patient, diagnosed on aspiration cytology.
  • [MeSH-major] Carcinoma, Giant Cell / pathology. Giant Cells / pathology. Osteoclasts / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17230568.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Ganguly R, Mitra S, Datta AK: Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. Indian J Pathol Microbiol; 2010 Apr-Jun;53(2):337-9

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  • [Title] Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland.
  • Various combinations of thyroid carcinomas have been reported including those between different cancers of follicular cell origin and those between follicular and C-cell histogenesis.
  • Accordingly, anaplastic carcinomas have been seen to coincide with simultaneous papillary and follicular cancers.
  • We report a case of composite anaplastic and papillary cancer on one thyroid lobe with a follicular carcinoma in the other lobe in a female patient aged 64 years.
  • The patient also had a separate and independent follicular adenoma in the same lobe as the composite anaplastic and papillary carcinoma.
  • The papillary carcinoma was continuous with the anaplastic carcinoma.
  • This could result from the dedifferentiation of a pre-existing differentiated carcinoma.
  • [MeSH-major] Adenocarcinoma, Follicular / complications. Adenoma / complications. Carcinoma / complications. Carcinoma, Papillary / complications. Thyroid Gland / pathology

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  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):434-5 [21623130.001]
  • [CommentIn] Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):414-5; author reply 415 [21623114.001]
  • (PMID = 20551551.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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90. Gualco G, Ojopi EB, Chioato L, Cordeiro DL, Negretti F, Bacchi CE: Postsplenectomy sclerosing extramedullary hematopoietic tumor with unexpected good clinical evolution: morphologic, immunohistochemical, and molecular analysis of one case and review of the literature. Appl Immunohistochem Mol Morphol; 2010 May;18(3):291-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postsplenectomy sclerosing extramedullary hematopoietic tumor with unexpected good clinical evolution: morphologic, immunohistochemical, and molecular analysis of one case and review of the literature.
  • Nonchronic myeloid leukemia myeloproliferative neoplasm included a JAK2 mutation as part of the diagnosis algorithm.
  • Morphologically differential diagnoses considered in the evaluation of this entity and in our case included sarcomas mainly liposarcoma, anaplastic carcinoma, and Hodgkin lymphoma.

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  • (PMID = 20042850.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2
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91. Ji Y, Kuang TT, Tan YS, Chen Y, Zeng HY, Jin DY: Pancreatic primary lymphoma: a case report and review of the literature. Hepatobiliary Pancreat Dis Int; 2005 Nov;4(4):622-6
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  • The patient received a Whipple's operation and intraoperative frozen sections of the mass showed an anaplastic carcinoma.
  • CONCLUSIONS: The proper diagnosis of the tumor should be made with CD20 and Bcl-6 immunohistochemical study.
  • Radical surgery is indicated for resectable carcinoma but not for a chemosensitive lymphoma.
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 16286277.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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92. Liang HH, Wu CH, Tam KW, Chai CY, Lin SE, Chen SC: Thyroid metastasis in a patient with hepatocellular carcinoma: case report and review of literature. World J Surg Oncol; 2007;5:144
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  • [Title] Thyroid metastasis in a patient with hepatocellular carcinoma: case report and review of literature.
  • Although lung, renal, and breast cancer are probably the most common primary sites, a number of cancers have been reported to metastasize to the thyroid synchronously with diagnosis of primary tumor or years after apparently curative treatment.
  • CASE PRESENTATION: We report a rare case of a hepatocellular carcinoma metasatic to the thyroid.
  • The patient presented seven months after original diagnosis and treatment with hepatic lobectomy with multiple neck lesions producing a mass effect on the trachea and bilateral lymphadenopathy.
  • Fine-needle aspiration revealed highly anaplastic carcinoma, and immunohistochemistry confirmed hepatocellular carcinoma.
  • In cases where cytology or histology is not diagnostic, immunohistochemistry may be definitive in making the diagnosis.
  • [MeSH-major] Carcinoma / diagnosis. Carcinoma, Hepatocellular / secondary. Liver Neoplasms / pathology. Thyroid Neoplasms / secondary

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  • (PMID = 18157914.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2246133
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93. Ito Y, Takano T, Miyauchi A: Apolipoprotein e expression in anaplastic thyroid carcinoma. Oncology; 2006;71(5-6):388-93
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  • [Title] Apolipoprotein e expression in anaplastic thyroid carcinoma.
  • However, recently the relationship between Apo E and carcinoma progression has been investigated.
  • In this study, we investigated Apo E expression in thyroid carcinoma at both the protein and molecular levels.
  • RESULTS: In RT-PCR and in situ hybridization, the Apo E mRNA expression level was very low in papillary and follicular carcinomas as well as normal thyroid, but was dramatically elevated in anaplastic carcinoma.
  • In an immunohistochemical study, 32 of 33 anaplastic carcinomas (97.0%) showed high levels of Apo E expression, but this phenomenon was seen only in 1 of 51 papillary carcinomas (2.0%).
  • None of the follicular carcinomas or adenomas showed high levels of Apo E expression.
  • CONCLUSIONS: These findings suggest that Apo E is one of the typical biological characteristics of anaplastic thyroid carcinoma.
  • [MeSH-major] Adenoma / metabolism. Apolipoproteins E / biosynthesis. Biomarkers, Tumor / biosynthesis. Carcinoma / metabolism. Carcinoma, Papillary / metabolism. Thyroid Neoplasms / metabolism

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 17690558.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Biomarkers, Tumor; 0 / RNA, Messenger
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94. Kim TY, Kim WB, Song JY, Rhee YS, Gong G, Cho YM, Kim SY, Kim SC, Hong SJ, Shong YK: The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma. Clin Endocrinol (Oxf); 2005 Nov;63(5):588-93
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  • BACKGROUND: The BRAF(V600E) mutation, the most common genetic alteration reported in papillary thyroid carcinoma, has been associated with poor prognostic factors.
  • PATIENTS AND METHODS: DNA was extracted from paraffin-embedded thyroid tumour specimens taken from 60 patients with conventional micro-PTC, as well as from nine patients with follicular variant papillary carcinoma, six with nodular hyperplasia, four with follicular carcinoma (including one with Hürthle cell carcinoma), four with follicular adenoma (including two with Hürthle cell adenoma) and one each with medullary carcinoma, poorly differentiated carcinoma and anaplastic carcinoma.

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  • (PMID = 16268813.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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95. Pallante P, Berlingieri MT, Troncone G, Kruhoffer M, Orntoft TF, Viglietto G, Caleo A, Migliaccio I, Decaussin-Petrucci M, Santoro M, Palombini L, Fusco A: UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas. Br J Cancer; 2005 Aug 22;93(4):464-71
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  • [Title] UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.
  • The hybridisation of an Affymetrix HG_U95Av2 oligonucleotide array with RNAs extracted from six human thyroid carcinoma cell lines and a normal human thyroid primary cell culture led us to the identification of the UbcH10 gene that was upregulated by 150-fold in all of the carcinoma cell lines in comparison to the primary culture cells of human normal thyroid origin.
  • Immunohistochemical studies performed on paraffin-embedded tissue sections showed abundant UbcH10 levels in thyroid anaplastic carcinoma samples, whereas no detectable UbcH10 expression was observed in normal thyroid tissues, in adenomas and goiters.
  • Papillary and follicular carcinomas were only weakly positive.
  • The block of UbcH10 protein synthesis induced by RNA interference significantly reduced the growth rate of thyroid carcinoma cell lines.
  • Taken together, these results would indicate that UbcH10 overexpression is involved in thyroid cell proliferation, and may represent a marker of thyroid anaplastic carcinomas.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / genetics. Carcinoma / pathology. Thyroid Neoplasms / genetics. Thyroid Neoplasms / pathology. Ubiquitin-Conjugating Enzymes / analysis

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  • (PMID = 16106252.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.3.2.19 / UBE2C protein, human; EC 6.3.2.19 / Ubiquitin-Conjugating Enzymes
  • [Other-IDs] NLM/ PMC2361574
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96. Dresen RC, Beets GH, Vliegen RF, Creytens DH, Beets-Tan RG: Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features. Br J Radiol; 2008 Oct;81(970):e249-51
MedlinePlus Health Information. consumer health - Bladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linitis plastica of the rectum secondary to bladder carcinoma: a report of two cases and its MR features.
  • Rectal linitis plastica (RLP) is a circumferentially infiltrating intramural anaplastic carcinoma that results in a rigid constricted rectum with thickened walls.
  • A long delay between the onset of symptoms and the diagnosis often occurs because RLP can mimic a lot of diseases and endoscopy and biopsies are often negative, owing to the fact that the mucosa is frequently unaffected in RLP.
  • We present the first report of the MR features of secondary rectal linitis plastica from a bladder carcinoma.
  • It is important to establish the diagnosis of RLP early because of its bad prognosis.
  • The value of MRI in supporting the diagnosis of RLP should not be underestimated.
  • As endoscopy plus biopsy can often be negative, we suggest that, if pelvic MRI shows a concentric double layered thickening of the rectal wall over a long segment, then the diagnosis of RLP should be considered.
  • This should prompt further investigations either to confirm or rule out the diagnosis of RLP by performing endoscopy with deep rectal wall biopsies.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Transitional Cell / secondary. Linitis Plastica / secondary. Rectal Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • (PMID = 18796553.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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97. Mastoraki A, Papanikolaou IS, Sakorafas G, Safioleas M: Facing the challenge of managing linitis plastica--review of the literature. Hepatogastroenterology; 2009 Nov-Dec;56(96):1773-8
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Linitis Plastica (LP) denotes a diffuse, intra-murally infiltrating, anaplastic carcinoma in a hollow structure resulting in a shrunken organ with thickened walls.
  • Diagnosis of LP-type adenocarcinomas of the stomach has traditionally been achieved by brush cytology and mucosal biopsy.
  • Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) contributes to the detection of abundant, independent malignant cells indicative of an anaplastic neoplasm.

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  • (PMID = 20214236.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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98. Pruyt M, Devriendt D, Vanneste A: Malignant melanoma and adenocarcinoma of a Barrett oesophagus. Acta Chir Belg; 2006 Sep-Oct;106(5):616-8
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  • The diagnosis of a malignant melanoma can be difficult but can be made by tissue examination with a special immunoreaction with several markers to see it expresses S-100, but lacks activity for KER and EMA.
  • S-100 is relatively non-specific as a single immunodeterminant in the diagnostic separation of melanoma and anaplastic carcinoma, but very sensitive.

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  • (PMID = 17168284.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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99. Papi G, Corrado S, LiVolsi VA: Primary spindle cell lesions of the thyroid gland; an overview. Am J Clin Pathol; 2006 Jun;125 Suppl:S95-123
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary T-SCL can be derivedfromfollicular, C-cell (parafollicular), or mesenchymal components and may be the result of reactive or neoplastic processes, including post-fine-needle aspiration spindle cell nodules, Riedel thyroiditis, solitary fibrous tumor, leiomyoma, peripheral nerve sheath tumor, hyalinizing trabecular tumor, spindle epithelial tumor with thymus-like differentiation, follicular dendritic cell tumor, medullary carcinoma, papillary carcinoma, anaplastic carcinoma, sarcoma, squamous cell carcinoma, and carcinoma showing thymus-like differentiation.

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  • (PMID = 16830961.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 354
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100. Russo D, Bisca A, Celano M, Talamo F, Arturi F, Scipioni A, Presta I, Bulotta S, Ferretti E, Filetti S, Scaloni A, Damante G, Tell G: Proteomic analysis of human thyroid cell lines reveals reduced nuclear localization of Mn-SOD in poorly differentiated thyroid cancer cells. J Endocrinol Invest; 2005 Feb;28(2):137-44
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  • Nuclear extracts from the well differentiated TPC-1 (from papillary carcinoma) and the poorly differentiated ARO (from anaplastic carcinoma) cells showed an overall similar pattern of protein expression as revealed by two-dimensional gel electrophoresis analysis.
  • A similar expression pattern of nuclear Mn-SOD was detected by immunohistochemistry in human thyroid tumors, with the lowest or absent detection in anaplastic carcinomas.
  • [MeSH-major] Carcinoma / enzymology. Cell Nucleus / enzymology. Proteomics. Superoxide Dismutase / metabolism. Thyroid Neoplasms / enzymology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Follicular / enzymology. Adenocarcinoma, Follicular / pathology. Blotting, Western. Carcinoma, Papillary / enzymology. Carcinoma, Papillary / pathology. Cell Line, Tumor. Fluorescent Antibody Technique. Humans. Immunohistochemistry. In Vitro Techniques. Tissue Distribution

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  • (PMID = 15887859.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] EC 1.15.1.1 / Superoxide Dismutase
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