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1. Jeong SM, Chung YG, Lee JB, Shin IY: Intracranial dissemination from spinal cord anaplastic astrocytoma. J Korean Neurosurg Soc; 2010 Jan;47(1):68-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intracranial dissemination from spinal cord anaplastic astrocytoma.
  • We report a case of intracranial dissemination developing approximately 4 months after partial removal of a spinal cord anplastic astrocytoma in a 22-year-old male.
  • Spinal magnetic resonance (MR) images disclosed multiple intramedullary lesions at the T3-11.
  • The final histologic diagnosis was anaplastic astrocytoma.
  • He underwent computed tomography-guided stereotactic biopsy and histological appearance was consistent with anaplastic astrocytoma.
  • The clinical course indicates that the tumor originated in the spinal cord and extended into the subarachnoid space, first the spinal canal and later intracranial.

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  • (PMID = 20157383.001).
  • [ISSN] 1598-7876
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2817520
  • [Keywords] NOTNLM ; Anaplastic astrocytoma / Intracranial dissemination / Spinal cord
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2. Tendulkar RD, Pai Panandiker AS, Wu S, Kun LE, Broniscer A, Sanford RA, Merchant TE: Irradiation of pediatric high-grade spinal cord tumors. Int J Radiat Oncol Biol Phys; 2010 Dec 01;78(5):1451-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Irradiation of pediatric high-grade spinal cord tumors.
  • PURPOSE: To report the outcome using radiation therapy (RT) for pediatric patients with high-grade spinal cord tumors.
  • METHODS AND MATERIALS: A retrospective chart review was conducted that included 17 children with high-grade spinal cord tumors treated with RT at St. Jude Children's Research Hospital between 1981 and 2007.
  • The tumor diagnosis was glioblastoma multiforme (n = 7), anaplastic astrocytoma (n = 8), or anaplastic oligodendroglioma (n = 2).
  • Local tumor progression at 12 months (79% vs. 30%, p = 0.02) and median survival (13.1 vs. 27.2 months, p = 0.09) were worse for patients with glioblastoma multiforme compared with anaplastic astrocytoma or oligodendroglioma.
  • CONCLUSIONS: High-grade spinal cord primary tumors in children have a poor prognosis.
  • [MeSH-major] Astrocytoma / radiotherapy. Oligodendroglioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20346593.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / P30 CA 21765
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T: Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation. Neuro Oncol; 2009 Aug;11(4):446-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation.
  • Some PXAs are accompanied by anaplastic features and are difficult to manage because of frequent recurrences that lead to early death.
  • We report a case of PXA with anaplastic features treated with stereotactic irradiation (STI) that resulted in long-term control of repeatedly recurring nodules throughout the neuraxis.
  • The tumor was resected and diagnosed as PXA with anaplastic features.
  • Two years later, the patient developed a tumor nodule in the cervical spinal cord that histologically corresponded to a small-cell glioma with high cellularity and prominent MIB-1 (mindbomb homolog 1) labeling.
  • In the following months, multiple nodular lesions appeared throughout the CNS, and STI was performed six times for eight intracranial lesions using Gamma Knife and twice using a linear accelerator, for three spinal cord lesions in total.
  • STI may be an effective therapeutic tool for controlling nodular dissemination of PXA with anaplastic features.
  • [MeSH-major] Astrocytoma / surgery. Brain Neoplasms / surgery. Radiosurgery

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  • (PMID = 19164434.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2743225
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4. Gibson CJ, Parry NM, Jakowski RM, Eshar D: Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris). Vet Pathol; 2008 Nov;45(6):934-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic astrocytoma in the spinal cord of an African pygmy hedgehog (Atelerix albiventris).
  • Grossly, the bladder was large and flaccid and the cervical and lumbar spinal cord were regionally enlarged, light grey, and friable with multifocal hemorrhages.
  • The thoracic spinal cord was grossly normal.
  • Microscopically all regions of the spinal cord had similar changes, although the cervical and lumbar sections were most severely affected.
  • These regions were completely effaced by a moderately cellular infiltration of highly pleomorphic polygonal to spindle shaped cells, mineralization, and necrosis, which were most consistent with anaplastic astrocytoma.
  • The thoracic spinal cord white matter was similarly infiltrated by the neoplastic cells, with perivascular extension into the otherwise normal grey matter.
  • A diagnosis of anaplastic astrocytoma was confirmed using immunohistochemical stains that were positive for glial fibrillary acidic protein and S100.
  • [MeSH-major] Astrocytoma / veterinary. Hedgehogs. Spinal Cord Neoplasms / veterinary

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  • (PMID = 18984799.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Hébert-Blouin MN, Bishop AT, Shin AY, Wetmore C, Spinner RJ: Tardy spinal cord tumor following avulsive brachial plexus injury: coincidental or causal? World Neurosurg; 2010 Aug-Sep;74(2-3):368-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tardy spinal cord tumor following avulsive brachial plexus injury: coincidental or causal?
  • RESULTS: Magnetic resonance imaging and computed tomography myelogram revealed spinal cord herniation at the same level of the previous nerve root avulsions.
  • Surgical open biopsy demonstrated a spinal cord anaplastic astrocytoma.
  • The probable coincidental versus possible causal interrelationship of these two processes (BPI and spinal cord tumor) is discussed, but no conclusions can be reached.
  • [MeSH-major] Astrocytoma / etiology. Brachial Plexus / injuries. Spinal Cord Neoplasms / etiology

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] World Neurosurg. 2010 Aug-Sep;74(2-3):275-6 [21492559.001]
  • (PMID = 21492572.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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6. Seo HS, Kim JH, Lee DH, Lee YH, Suh SI, Kim SY, Na DG: Nonenhancing intramedullary astrocytomas and other MR imaging features: a retrospective study and systematic review. AJNR Am J Neuroradiol; 2010 Mar;31(3):498-503
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: In the retrospective study, 6 astrocytomas (32%), including 2 anaplastic astrocytomas, did not enhance at all.
  • In the literature review, the frequency of nonenhancing intramedullary astrocytomas was 14 of 76 (18%), including 2 anaplastic astrocytomas.
  • Therefore, astrocytoma must remain in the differential diagnosis of nonenhancing intramedullary lesions, particularly if the lesion demonstrates a prominent mass effect or cord expansion.
  • [MeSH-major] Astrocytoma / pathology. Magnetic Resonance Imaging / methods. Spinal Cord Neoplasms / pathology

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  • (PMID = 19875469.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
  • [Number-of-references] 21
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7. Simal-Julián JA, Sanchis-Martín R, Prat-Acín R, Miranda-Lloret P, Conde-Sardón R, Cárdenas-Ruiz-Valdepeñas E, Beltrán-Giner A: [Spinal pleomorphic xantoastrocytoma. Case report]. Neurocirugia (Astur); 2010 Oct;21(5):390-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Spinal pleomorphic xantoastrocytoma. Case report].
  • [Transliterated title] Xantoastrocitoma pleomórfico espinal. Caso clínico.
  • INTRODUCTION: we report the clinical, radiological and pathological features of a spinal pleomorphic xanthoastrocytoma, an unusual neoplastic entity in a really rare location, establish an appropriated management of these lesions and review the short available english literature.
  • The differential imagine diagnosis was established between intramedullary astrocytoma and ependimoma.
  • DISCUSSION AND CONCLUSION: comparing to published cases about intracranial pleomorphic xanthoastrocytomas, spinal pleomorphic xanthoastrocytomas (SPXA) present different epidemiological characteristics.
  • The hypothesis about a more aggressive behaviour of PXA in spinal cord may be corroborated after literature review.
  • Adyuvant radiotherapy should only be considered when there is postoperative residual tumour and/or anaplastic features.
  • [MeSH-major] Astrocytoma. Spinal Cord Neoplasms

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  • (PMID = 21042690.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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8. Morgan RJ, Synold T, Mamelak A, Lim D, Al-Kadhimi Z, Twardowski P, Leong L, Chow W, Margolin K, Shibata S, Somlo G, Yen Y, Frankel P, Doroshow JH: Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors. Cancer Chemother Pharmacol; 2010 Oct;66(5):927-33
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  • [Title] Plasma and cerebrospinal fluid pharmacokinetics of topotecan in a phase I trial of topotecan, tamoxifen, and carboplatin, in the treatment of recurrent or refractory brain or spinal cord tumors.
  • The tumors included glioblastoma (6), anaplastic astrocytoma (2), metastatic non-small cell (3), small cell lung (2), and one each with medulloblastoma, ependymoma, and metastatic breast or colon carcinoma.

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  • (PMID = 20107803.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA033572; United States / NCI NIH HHS / CA / P30 CA033572-26; United States / NCI NIH HHS / CA / CA 33572
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 094ZI81Y45 / Tamoxifen; 7M7YKX2N15 / Topotecan; BG3F62OND5 / Carboplatin
  • [Other-IDs] NLM/ NIHMS335377; NLM/ PMC3265324
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9. McGirt MJ, Goldstein IM, Chaichana KL, Tobias ME, Kothbauer KF, Jallo GI: Extent of surgical resection of malignant astrocytomas of the spinal cord: outcome analysis of 35 patients. Neurosurgery; 2008 Jul;63(1):55-60; discussion 60-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extent of surgical resection of malignant astrocytomas of the spinal cord: outcome analysis of 35 patients.
  • OBJECTIVE: The optimal management of malignant intramedullary spinal cord astrocytomas remains controversial.
  • We report the outcomes of the surgical management of 35 malignant spinal cord astrocytomas and assess the association of extent of resection with survival after aggressive resection of these tumors.
  • METHODS: An institutional intramedullary spinal cord tumor database (1990-2002) was reviewed to identify all patients treated for malignant astrocytomas of the spinal cord (anaplastic astrocytoma [AA] or glioblastoma multiforme [GBM]).
  • CONCLUSION: Neurological function can be preserved with aggressive resection of malignant intramedullary spinal astrocytomas; however, motor decline may be observed in many cases.
  • Biopsy alone may not provide the best outcomes for patients with malignant spinal cord tumors.
  • [MeSH-major] Astrocytoma / surgery. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery

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  • (PMID = 18728568.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Khongkhatithum C, Visudtibhan A, Chiemchanya S, Visudhiphan P, Sanvivad P, Larbcharoensub N, Phudhicharoenrat S: Multicentric anaplastic astrocytoma in a child. J Clin Neurosci; 2007 Feb;14(2):176-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multicentric anaplastic astrocytoma in a child.
  • We report a rare case of anaplastic astrocytoma with multicentric central nervous system lesions in a 10-year-old girl presenting with a 1-month history of progressive headache and paraparesis.
  • Cranial and spinal magnetic resonance imaging revealed multiple tumour foci within the suprasellar region, cerebellar hemisphere, cervical and thoracic cords.
  • The histological diagnosis was anaplastic astrocytoma based on the WHO classification.
  • [MeSH-major] Astrocytoma / pathology. Brain Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Spinal Cord Neoplasms / pathology

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  • (PMID = 17161293.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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11. Passone E, Pizzolitto S, D'Agostini S, Skrap M, Gardiman MP, Nocerino A, Scarzello G, Perilongo G: Non-anaplastic pleomorphic xanthoastrocytoma with neuroradiological evidences of leptomeningeal dissemination. Childs Nerv Syst; 2006 Jun;22(6):614-8
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  • [Title] Non-anaplastic pleomorphic xanthoastrocytoma with neuroradiological evidences of leptomeningeal dissemination.
  • CASE REPORT: A case of a non-anaplastic pleomorphic xanthoastrocytoma (PXA) presenting with leptomeningeal dissemination (LMD) affecting a 9-year-old girl is presented.
  • CONCLUSION: To our knowledge, this is the first case of a non-anaplastic PXA presenting with disseminated disease.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Meningeal Neoplasms / complications. Neoplasm Recurrence, Local / etiology
  • [MeSH-minor] Child. Disease Progression. Female. Glial Fibrillary Acidic Protein / metabolism. Humans. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging / methods. Spinal Cord / pathology

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  • (PMID = 16369851.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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12. Hyder DJ, Sung L, Pollack IF, Gilles FH, Yates AJ, Davis RL, Boyett JM, Finlay JL: Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience. J Neurooncol; 2007 May;83(1):1-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic mixed gliomas and anaplastic oligodendroglioma in children: results from the CCG 945 experience.
  • PURPOSE: To review interpathologist diagnosis variability and survival of children treated for either anaplastic mixed glioma (AMG) or anaplastic oligodendroglioma (AO) with surgery, irradiation and chemotherapy.
  • However, central review established that only nine of 26 children had AMG: either mixed oligoastrocytoma (MOA) or anaplastic mixed oligoastrocytoma (AOA) and only one had AO.
  • [MeSH-minor] Adolescent. Astrocytoma / diagnosis. Astrocytoma / therapy. Brain Neoplasms / diagnosis. Brain Neoplasms / therapy. Child. Child, Preschool. Cohort Studies. Drug Therapy. Female. Humans. Infant. Male. Neurosurgical Procedures. Radiotherapy. Spinal Cord Neoplasms / diagnosis. Spinal Cord Neoplasms / therapy. Survival Analysis

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  • (PMID = 17252186.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Netherlands
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13. Tobias ME, McGirt MJ, Chaichana KL, Goldstein IM, Kothbauer KF, Epstein F, Jallo GI: Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst; 2008 Feb;24(2):219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of long intramedullary spinal cord tumors.
  • OBJECT: Spinal cord tumors represent approximately 10-20% of primary central nervous system tumors.
  • MATERIALS AND METHODS: We retrospectively reviewed all patients undergoing surgical resection of longitudinally extensive intramedullary spinal cord tumors involving the majority of the spinal cord between 1990 and 2002.
  • Pathology revealed astrocytoma in six cases (two pilocytic, four grade II), gangliogliomas in four cases, oligodendroglioma in two cases (one anaplastic), and lipoma in one case.
  • One (8%) patient died from progression of anaplastic oligodendroglioma, and two (15%) underwent reoperation for recurrent tumor (ganglioglioma, grade II astrocytoma).
  • Five (38%) patients required fusion for progressive spinal deformity.
  • CONCLUSION: Gross total resection of holocord and longitudinally extensive intramedullary spinal cord tumors can be achieved with preservation of long-term neurological function in many cases.
  • Serial imaging is recommended to guide subsequent resection for tumor recurrence and stabilization of progressive spinal deformity.
  • [MeSH-major] Spinal Cord Neoplasms / surgery

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  • (PMID = 17639420.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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14. Oake C, Borg MF, Hanieh A, Byard RW: Childhood glioblastoma multiforme of the spinal cord. Australas Radiol; 2006 Aug;50(4):360-3
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  • [Title] Childhood glioblastoma multiforme of the spinal cord.
  • Astrocytoma accounts for more than 50% of all central nervous system tumours diagnosed, with particular prevalence in the 15- to 34-year-old age bracket, rarely arising in younger children.
  • The patient proceeded to biopsy and partial excision of the tumour through laminectomy, histology confirming an anaplastic astrocytoma (glioblastoma multiforme), St Anne Mayo grade 4.
  • This report highlights the efficacy of combined surgery and radiation therapy in the management of spinal cord glioblastoma multiforme in preventing tumour recurrence, with acceptable morbidity.
  • [MeSH-major] Glioblastoma / radiotherapy. Glioblastoma / surgery. Spinal Cord Neoplasms / radiotherapy. Spinal Cord Neoplasms / surgery

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  • (PMID = 16884424.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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15. Marrufo M, Politsky J, Mehta S, Morgan JC, Sethi KD: Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma. Mov Disord; 2007 Sep 15;22(12):1801-3
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  • [Title] Paroxysmal Kinesigenic Segmental Myoclonus due to a spinal cord glioma.
  • He was subsequently diagnosed with a cervical cord anaplastic astrocytoma on MRI.
  • We could not identify previous reports of paroxysmal myoclonus secondary to a spinal cord neoplasm.
  • [MeSH-major] Glioma / complications. Myoclonus / etiology. Spinal Cord Neoplasms / complications

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  • [Copyright] (c) 2007 Movement Disorder Society.
  • (PMID = 17595044.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Klase D, Gottschalk S, Reusche E, Hagel C, Goebel E, Tronnier V, Giese A: Lumbosacral glioblastoma and leptomeningeal gliomatosis complicating the course of a cervicothoracic astrocytoma WHO grade II. Childs Nerv Syst; 2007 Aug;23(8):907-12
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  • [Title] Lumbosacral glioblastoma and leptomeningeal gliomatosis complicating the course of a cervicothoracic astrocytoma WHO grade II.
  • CASE REPORT: The reported female patient underwent sub-total resection of an intra-medullary cervicothoracic astrocytoma classified as WHO grade II in 1984 at the age of 18 months and received local irradiation.
  • Sixteen years later, a small recurrent cervicothoracic tumour was found and spinal seeding to the equine nerve roots and the left cerebellar cortex was apparent on MRI.
  • DISCUSSION AND CONCLUSION: Anaplastic progression and dissemination of spinal astrocytomas even two decades after initial diagnosis and treatment are rare.
  • [MeSH-major] Astrocytoma / complications. Glioblastoma / complications. Meningeal Neoplasms / complications. Spinal Cord Neoplasms / complications

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  • (PMID = 17440736.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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17. Yanni DS, Ulkatan S, Deletis V, Barrenechea IJ, Sen C, Perin NI: Utility of neurophysiological monitoring using dorsal column mapping in intramedullary spinal cord surgery. J Neurosurg Spine; 2010 Jun;12(6):623-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Utility of neurophysiological monitoring using dorsal column mapping in intramedullary spinal cord surgery.
  • OBJECT: Intramedullary spinal cord tumors can displace the surrounding neural tissue, causing enlargement and distortion of the normal cord anatomy.
  • Standard anatomical landmarks may be misleading in patients with intramedullary spinal cord tumors due to cord rotation, edema, neovascularization, or local scar formation.
  • METHODS: A group of 10 patients with cervical and thoracic intramedullary spinal cord lesions underwent dorsal column mapping in which a strip electrode was used to define the midline.
  • After the laminectomy and durotomy, a custom-designed multielectrode grid was placed on the exposed dorsal surface of the spinal cord.
  • This strip electrode maps the amplitude gradient of conducted spinal somatosensory evoked potentials elicited by bilateral tibial nerve stimulation.
  • There were 4 ependymomas, 1 subependymoma, 1 gangliocytoma, 1 anaplastic astrocytoma, 1 cavernous malformation, and 2 symptomatic syringes requiring shunting.
  • CONCLUSIONS: Dorsal column mapping is a useful technique for guiding the surgeon in locating the midline for myelotomy in intramedullary spinal cord surgery.
  • [MeSH-major] Evoked Potentials, Somatosensory / physiology. Monitoring, Intraoperative. Spinal Cord / physiopathology. Spinal Cord Neoplasms / surgery

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  • (PMID = 20515347.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Okazaki T, Kageji T, Matsuzaki K, Horiguchi H, Hirose T, Watanabe H, Ohnishi T, Nagahiro S: Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature. J Neurooncol; 2009 Sep;94(3):431-7
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  • [Title] Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature.
  • We report a 5 year-old boy with primary anaplastic pleomorphic xanthoastrocytoma (PXA) with whole neuroaxis dissemination at diagnosis who experienced the sudden onset of generalized convulsion.
  • Head- and spinal magnetic resonance imaging (MRI) showed widespread gadolinium (Gd)-enhanced lesions extending to the bilateral frontal- and medial temporal lobes and the spinal cord.
  • Under a histopathologic diagnosis of anaplastic PXA he underwent adjuvant chemotherapy consisting of 12 cycles of carboplatin and vincristine.
  • We report a very rare pediatric case of primary anaplastic PXA with dissemination involving the entire neuroaxis at the time of diagnosis.
  • [MeSH-major] Astrocytoma / diagnosis. Brain Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Neoplasms, Complex and Mixed / diagnosis
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Head / pathology. Head / radiography. Humans. Male. Spinal Cord / pathology. Spinal Cord / radiography. Tomography, X-Ray Computed / methods


19. Shrivastava RK, Epstein FJ, Perin NI, Post KD, Jallo GI: Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis. J Neurosurg Spine; 2005 Mar;2(3):249-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis.
  • OBJECT: Intramedullary spinal cord tumors (IMSCTs) in the older-age adult population pose complex management issues regarding the extent of resection and functional outcome, especially in terms of quality of life.
  • There were two deaths due tumor progression (both malignant tumors) and one recurrence (anaplastic astrocytoma).
  • [MeSH-major] Ependymoma / surgery. Spinal Cord Neoplasms / surgery
  • [MeSH-minor] Aged. Astrocytoma / surgery. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Quality of Life. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 15796348.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Katoh N, Shirato H, Aoyama H, Onimaru R, Suzuki K, Hida K, Miyasaka K, Iwasaki Y: Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor. J Neurooncol; 2006 May;78(1):63-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumor.
  • PURPOSE: To retrospectively analyze the outcome of post-operative radiotherapy for spinal cord glioma with the emphasis on the hypofractionated radiotherapy boost for dose escalation as a treatment option for high-grade spinal cord astrocytic tumors.
  • MATERIALS AND METHODS: Forty-one patients with spinal cord glioma received post-operative radiotherapy between 1979 and 2003.
  • Among 11 patients with high-grade astrocytic tumors, 5 with anaplastic astrocytoma and 1 with glioblastoma received hypofractionated radiotherapy boost for dose escalation.
  • [MeSH-major] Dose Fractionation. Glioma / radiotherapy. Spinal Cord Neoplasms / radiotherapy

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  • (PMID = 16314938.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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21. Ewelt C, Stummer W, Klink B, Felsberg J, Steiger HJ, Sabel M: Cordectomy as final treatment option for diffuse intramedullary malignant glioma using 5-ALA fluorescence-guided resection. Clin Neurol Neurosurg; 2010 May;112(4):357-61
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  • BACKGROUND: We present a case of an anaplastic astrocytoma (WHO-grade III, AA III) in a 27-year-old woman treated by spinal cordectomy.
  • PATIENTS COURSE: The spinal cord was amputated caudally to the root entry zones of the T10 sensory roots.
  • CONCLUSION: Our observation suggests 5-ALA fluorescence-guided resections to be useful in the context of malignant spinal cord gliomas.
  • Furthermore, our particular case indicates that palliative spinal cordectomy with a wide margin and intraoperative resection using fluorescence guidance may be a final option for patients with recurrent spinal malignant glioma presenting with complete deficit below the lesion.
  • [MeSH-major] Aminolevulinic Acid. Astrocytoma / surgery. Cordotomy / methods. Neurosurgical Procedures / methods. Spinal Cord Neoplasms / surgery. Surgery, Computer-Assisted / methods

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20061079.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 88755TAZ87 / Aminolevulinic Acid
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22. Debono B, Derrey S, Rabehenoina C, Proust F, Freger P, Laquerrière A: Primary diffuse multinodular leptomeningeal gliomatosis: case report and review of the literature. Surg Neurol; 2006 Mar;65(3):273-82; discussion 282

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  • Magnetic resonance imaging revealed a multinodular enhancement of spinal nerve roots.
  • Histological examination revealed an anaplastic astrocytoma.
  • RESULTS: Complete neuraxis postmortem examination revealed no intraparenchymatous glioma and was conclusive for the diagnosis of primary leptomeningeal gliomatosis (astrocytic, World Health Organization grade III), with a multinodular pattern in the spinal cord, the brainstem, and the brain base with diffuse extension into the cerebellar subarachnoid spaces.
  • [MeSH-major] Astrocytoma / surgery. Meningeal Neoplasms / surgery. Neoplasms, Neuroepithelial / surgery. Peripheral Nervous System Neoplasms / surgery. Spinal Nerve Roots / surgery

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  • (PMID = 16488248.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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23. Salmaggi A, Fariselli L, Milanesi I, Lamperti E, Silvani A, Bizzi A, Maccagnano E, Trevisan E, Laguzzi E, Rudà R, Boiardi A, Soffietti R, Associazione Italiana di Neuro-oncologia: Natural history and management of brainstem gliomas in adults. A retrospective Italian study. J Neurol; 2008 Feb;255(2):171-7
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  • In 21 of the patients histology was obtained and in 20 it was informative (2 pilocytic astrocytoma, 9 low-grade astrocytoma, 8 anaplastic astrocytoma and 1 glioblastoma).
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Brain / pathology. Disease Progression. Female. Fluorodeoxyglucose F18. Humans. Image Processing, Computer-Assisted. Italy. Magnetic Resonance Imaging. Male. Middle Aged. Positron-Emission Tomography. Prognosis. Radiopharmaceuticals. Retrospective Studies. Spinal Cord / pathology. Survival Analysis. Treatment Outcome

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  • (PMID = 18293027.001).
  • [ISSN] 0340-5354
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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24. Guzman G, Oh S, Shukla D, Engelhard HH, Valyi-Nagy T: Expression of entry receptor nectin-1 of herpes simplex virus 1 and/or herpes simplex virus 2 in normal and neoplastic human nervous system tissues. Acta Virol; 2006;50(1):59-66
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  • To better understand the nectin-1 expression in normal and neoplastic human NS, immunohistochemistry was used to detect the nectin-1 expression in sections of normal human brain, spinal cord and trigeminal and dorsal root ganglia (n=10) and in sections of primary NS neoplasms (n=22).
  • Oligodendroglioma, ependymoma, pilocytic astrocytoma, pleomorphic xanthoastrocytoma, diffuse astrocytoma, anaplastic astrocytoma, glioblastoma multiforme and meningothelial meningioma showed weak focal nectin-1-positivity.

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  • (PMID = 16599187.001).
  • [ISSN] 0001-723X
  • [Journal-full-title] Acta virologica
  • [ISO-abbreviation] Acta Virol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / nectins
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25. Perez-Saldana MT, Vilar C, Geffner-Sclarsky D, Belenguer-Benavides A, Del Villar-Igea A, Gil-Fortuno M, Bahamonde D: [Meningoencephalomyelitis as the initial symptom of a brain tumour mimicking encephalitis due to herpes simplex virus: a case report]. Rev Neurol; 2007 Mar 16-31;44(6):348-52
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  • [Transliterated title] Meningoencefalomielitis como manifestacion inicial de un tumor cerebral que imita una encefalitis por virus del herpes simple: descripcion de un caso.
  • We report a case of meningoencephalomyelitis that initially presented as encephalitis due to herpes simplex virus (HSV) and which was finally seen to be an anaplastic oligoastrocytoma.
  • The polymerase chain reaction for the cerebrospinal fluid was positive for HSV and magnetic resonance imaging revealed diffuse compromise of right temporal lobe, the spinal cord and the cervical meninges.
  • [MeSH-major] Astrocytoma. Brain Neoplasms. Encephalitis, Herpes Simplex / etiology. Meninges / pathology. Meningitis / etiology

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  • (PMID = 17385171.001).
  • [ISSN] 0210-0010
  • [Journal-full-title] Revista de neurologia
  • [ISO-abbreviation] Rev Neurol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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26. Kim B, Chung CK, Myung JK, Park SH: Pleomorphic xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult. Pathol Res Pract; 2009;205(2):113-7
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  • The tumor was diagnosed as PXA with anaplastic feature (mitotic count: 5/10HPF), and the brain around the tumor showed dysmorphic neurons and balloon cells.
  • The patient's condition deteriorated, with tumor recurrence and widespread leptomeningeal seeding to the whole spinal cord.
  • [MeSH-major] Astrocytoma / complications. Astrocytoma / pathology. Brain Neoplasms / complications. Brain Neoplasms / pathology. Epilepsy, Temporal Lobe / complications. Malformations of Cortical Development / complications

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  • (PMID = 18657915.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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27. Narayana A, Yamada J, Berry S, Shah P, Hunt M, Gutin PH, Leibel SA: Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results. Int J Radiat Oncol Biol Phys; 2006 Mar 1;64(3):892-7
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  • Glioblastoma accounted for 70% of the cases, and anaplastic oligodendroglioma histology (pure or mixed) was seen in 15% of the cases.
  • The median progression-free survival time for anaplastic astrocytoma and glioblastoma histology was 5.6 and 2.5 months, respectively.
  • The overall survival time for anaplastic glioma and glioblastoma was 36 and 9 months, respectively.
  • However, IMRT resulted in a decreased maximum dose to the spinal cord, optic nerves, and eye by 16%, 7%, and 15%, respectively, owing to its improved dose conformality.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
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  • (PMID = 16458777.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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28. Benesch M, Wagner S, Berthold F, Wolff JE: Primary dissemination of high-grade gliomas in children: experiences from four studies of the Pediatric Oncology and Hematology Society of the German Language Group (GPOH). J Neurooncol; 2005 Apr;72(2):179-83
Hazardous Substances Data Bank. VINCRISTINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: A total of 10 patients (3.1%) (anaplastic astrocytoma: n=3, glioblastoma multiforme: n=6, diffuse intrinsic pontine glioma: n=1) had primary tumor dissemination.
  • The most frequent primary tumor sites were the cortex (n=4), followed by the ventricles (n=2), cerebellum (n=1), spinal cord (n=1), and pons (n=1).

  • Hazardous Substances Data Bank. ETOPOSIDE .
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  • (PMID = 15925999.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; H64JRU6GJ0 / trofosfamide
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29. Hanse MC, Franssen JH, Sleeboom HP, Hoffmann CF, Taal W: Two exceptional phenomena in an anaplastic oligo-astrocytoma. J Neurooncol; 2006 Jun;78(2):197
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two exceptional phenomena in an anaplastic oligo-astrocytoma.
  • [MeSH-major] Astrocytoma / secondary. Brain Neoplasms / pathology. Neoplasm Recurrence, Local / complications. Sagittal Sinus Thrombosis / etiology. Spinal Cord Neoplasms / secondary

  • Genetic Alliance. consumer health - Anaplastic Astrocytoma.
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  • (PMID = 16575535.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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