BioMedLib Search Engine
[ goto HOMEPAGE ]
Search the biomedical literature, for the most relevant articles.
Skip to content
Advanced Search
Search History
MeSH Query
Page Format
Query is expanded
Login
Skip to content
Export Citations
Search Results
RSS
Email
Articles' Details
Start new query
Reset All
Refine your query
(more in Advanced-Search):
Search all of MEDLINE
Focus on the recent 5 years
Focus on the current year
Focus on the last 30 days
More choices ...
Focus on articles with free fulltexts
More choices ...
Do simple 'keyword' search (no query expansion)
[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click
here to
RESET
all values
Click
here to
GO BACK
without resetting any value
Advanced Search
Submit one or more of the following items, and they will be searched along with your query in the search box above.
Any submit button will submit all of the items you have changed.
+
Publication-Date
Published in the last:
30 days
60 days
90 days
6 months
12 months
this year
2 years
3 years
5 years
10 years
Or published in the following date range: From (yyyy/mm/dd - month and day are optional)
to ('to' is optional)
+
Full Text
Retrieve articles with hyperlinks to:
full text (either free or subscription)
free full text
subscription full text
no full text link
+
Sort-Order
Sort the retrieved articles by:
relevance
publication date
+
Language
And with languages:
English
French
German
Italian
Japanese
Russian
Spanish
More languages:
Afrikaans
Albanian
Amharic
Arabic
Armenian
Azerbaijani
Bengali
Bosnian
Bulgarian
Catalan
Chinese
Czech
Danish
Dutch
Esperanto
Estonian
Finnish
Georgian
Scottish Gaelic
Greek, Modern
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Kinyarwanda
Korean
Latin
Latvian
Lithuanian
Macedonian
Malayalam
Maori
Malay
Multiple languages
Norwegian
Persian
Polish
Portuguese
Pushto
Romanian
Sanskrit
Serbian
Croatian
Slovak
Slovenian
Swedish
Thai
Turkish
Ukrainian
Undetermined
Urdu
Vietnamese
Welsh
+
Publication-Type
And with publication types:
Clinical Trial
Editorial
Letter
Meta-Analysis
Practice Guideline
Randomized Controlled Trial
Review
More publication types:
Addresses
Bibliography
Biography
Case Reports
Classical Article
Clinical Conference
Clinical Trial, Phase I
Clinical Trial, Phase II
Clinical Trial, Phase III
Clinical Trial, Phase IV
Comment
Comparative Study
Congresses
Consensus Development Conference
Consensus Development Conference, NIH
Controlled Clinical Trial
Corrected and Republished Article
Dictionary
Directory
Duplicate Publication
English Abstract
Evaluation Studies
Festschrift
Government Publications
Guideline
Historical Article
Interactive Tutorial
Interview
Introductory Journal Article
In Vitro
Journal Article
Lectures
Legal Cases
Legislation
Multicenter Study
News
Newspaper Article
Overall
Patient Education Handout
Periodical Index
Portraits
Published Erratum
Retracted Publication
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Retraction of Publication
Scientific Integrity Review
Technical Report
Twin Study
Validation Studies
+
Species
And for:
Humans
Animals
+
Gender
And for:
Male
Female
+
Age
And for these age groups:
Newborn: birth to 1 month
Infant: 1 to 23 months
Preschool child: 2 to 5 years
Child: 6 to 12 years
Adolescent: 13 to 18 years
Adult: 19 to 44 years
Middle aged: 45 to 64 years
Aged: 65+ years
80 and over: 80+ years
+
Title
And for this query matching the titles:
+
Transliterated-Title
And for this query matching the title in original language:
+
Abstract
And for this query matching the abstratcs:
+
Major-Mesh
And for this query matching the MeSH-Major terms:
+
Mesh
And for this query matching any MeSH terms:
+
Journal
And for one or more of these journal abbreviated names:
OR
OR
(see
title abbreviations
)
+
Volume
And with journal volume number:
+
Issue
And with journal issue number:
+
Page
And with page number:
+
ISSN
And with ISSN:
+
Publication-Place
And with journal's country of publication:
+
Author
And for...
all these author names:
AND
AND
(see
help
)
one or more of these author names:
OR
OR
but not having any of these unwanted author names:
NOT
NOT
+
Affiliation
And with affiliation to:
+
Has-Abstract
Find MEDLINE records with the abstract status:
has abstract
does not have abstract
include both record types
include both record types but rank higher the records having abstract (the default BML behavior)
+
PMID
Show me only articles for these PMIDs (PubMed IDs):
+
Semantic-Type
And with semantic types:
A. Entity
A1. Physical Object
A1.1. Organism
A1.1.1. Archaeon
A1.1.2. Bacterium
A1.1.3. Eukaryote
A1.1.3.1. Animal
A1.1.3.1.1. Vertebrate
A1.1.3.1.1.1. Amphibian
A1.1.3.1.1.2. Bird
A1.1.3.1.1.3. Fish
A1.1.3.1.1.4. Mammal
A1.1.3.1.1.4.1. Human
A1.1.3.1.1.5. Reptile
A1.1.3.2. Fungus
A1.1.3.3. Plant
A1.1.4. Virus
A1.2. Anatomical Structure
A1.2.1. Embryonic Structure
A1.2.2. Anatomical Abnormality
A1.2.2.1. Congenital Abnormality
A1.2.2.2. Acquired Abnormality
A1.2.3. Fully Formed Anatomical Structure
A1.2.3.1. Body Part, Organ, or Organ Component
A1.2.3.2. Tissue
A1.2.3.3. Cell
A1.2.3.4. Cell Component
A1.2.3.5. Gene or Genome
A1.3. Manufactured Object
A1.3.1. Medical Device
A1.3.1.1. Drug Delivery Device
A1.3.2. Research Device
A1.3.3. Clinical Drug
A1.4. Substance
A1.4.1. Chemical
A1.4.1.1. Chemical Viewed Functionally
A1.4.1.1.1. Pharmacologic Substance
A1.4.1.1.1.1. Antibiotic
A1.4.1.1.2. Biomedical or Dental Material
A1.4.1.1.3. Biologically Active Substance
A1.4.1.1.3.1. Neuroreactive Substance or Biogenic Amine
A1.4.1.1.3.2. Hormone
A1.4.1.1.3.3. Enzyme
A1.4.1.1.3.4. Vitamin
A1.4.1.1.3.5. Immunologic Factor
A1.4.1.1.3.6. Receptor
A1.4.1.1.4. Indicator, Reagent, or Diagnostic Aid
A1.4.1.1.5. Hazardous or Poisonous Substance
A1.4.1.2. Chemical Viewed Structurally
A1.4.1.2.1. Organic Chemical
A1.4.1.2.1.5. Nucleic Acid, Nucleoside, or Nucleotide
A1.4.1.2.1.6. Organophosphorus Compound
A1.4.1.2.1.7. Amino Acid, Peptide, or Protein
A1.4.1.2.1.8. Carbohydrate
A1.4.1.2.1.9. Lipid
A1.4.1.2.1.9.1. Steroid
A1.4.1.2.1.9.2. Eicosanoid
A1.4.1.2.2. Inorganic Chemical
A1.4.1.2.3. Element, Ion, or Isotope
A1.4.2. Body Substance
A1.4.3. Food
A2. Conceptual Entity
A2.1. Idea or Concept
A2.1.1. Temporal Concept
A2.1.2. Qualitative Concept
A2.1.3. Quantitative Concept
A2.1.4. Functional Concept
A2.1.4.1. Body System
A2.1.5. Spatial Concept
A2.1.5.1. Body Space or Junction
A2.1.5.2. Body Location or Region
A2.1.5.3. Molecular Sequence
A2.1.5.3.1. Nucleotide Sequence
A2.1.5.3.2. Amino Acid Sequence
A2.1.5.3.3. Carbohydrate Sequence
A2.1.5.4. Geographic Area
A2.2. Finding
A2.2.1. Laboratory or Test Result
A2.2.2. Sign or Symptom
A2.3. Organism Attribute
A2.3.1. Clinical Attribute
A2.4. Intellectual Product
A2.4.1. Classification
A2.4.2. Regulation or Law
A2.5. Language
A2.6. Occupation or Discipline
A2.6.1. Biomedical Occupation or Discipline
A2.7. Organization
A2.7.1. Health Care Related Organization
A2.7.2. Professional Society
A2.7.3. Self-help or Relief Organization
A2.8. Group Attribute
A2.9. Group
A2.9.1. Professional or Occupational Group
A2.9.2. Population Group
A2.9.3. Family Group
A2.9.4. Age Group
A2.9.5. Patient or Disabled Group
B. Event
B1. Activity
B1.1. Behavior
B1.1.1. Social Behavior
B1.1.2. Individual Behavior
B1.2. Daily or Recreational Activity
B1.3. Occupational Activity
B1.3.1. Health Care Activity
B1.3.1.1. Laboratory Procedure
B1.3.1.2. Diagnostic Procedure
B1.3.1.3. Therapeutic or Preventive Procedure
B1.3.2. Research Activity
B1.3.2.1. Molecular Biology Research Technique
B1.3.3. Governmental or Regulatory Activity
B1.3.4. Educational Activity
B1.4. Machine Activity
B2. Phenomenon or Process
B2.1. Human-caused Phenomenon or Process
B2.1.1. Environmental Effect of Humans
B2.2. Natural Phenomenon or Process
B2.2.1. Biologic Function
B2.2.1.1. Physiologic Function
B2.2.1.1.1. Organism Function
B2.2.1.1.1.1. Mental Process
B2.2.1.1.2. Organ or Tissue Function
B2.2.1.1.3. Cell Function
B2.2.1.1.4. Molecular Function
B2.2.1.1.4.1. Genetic Function
B2.2.1.2. Pathologic Function
B2.2.1.2.1. Disease or Syndrome
B2.2.1.2.1.1. Mental or Behavioral Dysfunction
B2.2.1.2.1.2. Neoplastic Process
B2.2.1.2.2. Cell or Molecular Dysfunction
B2.2.1.2.3. Experimental Model of Disease
B2.3. Injury or Poisoning
Page Format
Any submit button will submit all of the items you have changed.
[theme]
Use this page design theme:
original
twenty ten
[shown]
Results per page:
5
10
20
50
100
200
500
[expand/collapse]
show these sections expanded by default:
Advanced search
MeSH query
Search history
Page format
Query expansion
Articles details
Export citations
Email
[text size]
use this font size for text:
25%
50%
75%
100%
125%
150%
200%
or enter your choice of font size:
[page width]
use this page width (relative to the default initial value):
25%
50%
75%
100%
125%
150%
200%
or enter your choice of page width:
[highlight color]
use this color to highlight query words in the articles:
red
green
blue
black
purple
yellow
orange
navy
olive
maroon
none
[query history]
maximum number of queries shown in the history section:
[annotate]
Annotate these parts of each article:
title
abstract
both
none
Reset all values
Find best MeSH terms for
Search History
1
anaplastic astrocytoma of brain 2005:2010[pubdate] *count=100
485 results
Searchbox
Export
PDF
RSS
Email
Delete
Email this search result to the following email address:
[X] Close
Expand the query
'
anaplastic astrocytoma of brain
' expanded to all its synonyms;
details
Email the results to the following email address:
Export the checked citations in RIS format (RIS format is used by RefWorks, Endnote, among others).
Items 1 to 100 of about 485
1.
Jenkinson MD, Smith TS, Haylock B, Husband D, Shenoy A, Vinjamuri S, Walker C, Pietronigro D, Warnke PC:
Phase II trial of intratumoral BCNU injection and radiotherapy on untreated adult malignant glioma.
J Neurooncol
; 2010 Aug;99(1):103-13
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Twelve patients were enrolled; eight glioblastoma multiforme (GBM), four
anaplastic astrocytoma
(AA).
[MeSH-major]
Antineoplastic Agents, Alkylating / therapeutic use.
Brain
Neoplasms / drug therapy.
Brain
Neoplasms / radiotherapy. Carmustine / therapeutic use. Glioma / drug therapy. Glioma / radiotherapy
[MeSH-minor]
Aged.
Brain
Mapping. Cerebrovascular Circulation / drug effects. Disease-Free Survival. Female. Fluorodeoxyglucose F18. Humans. Injections, Intramuscular / methods. Karnofsky Performance Status. Magnetic Resonance Imaging / methods. Male. Middle Aged. Thallium. Tomography Scanners, X-Ray Computed. Tomography, Emission-Computed, Single-Photon / methods. Tomography, X-Ray Computed / methods
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
Carmustine
.
Hazardous Substances Data Bank.
THALLIUM, ELEMENTAL
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Neuro Oncol. 2000 Jan;2(1):45-59
[
11302254.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1989 Dec;17(6):1351-6
[
2689399.001
]
[Cites]
J Neurooncol. 2003 May;62(3):251-8
[
12777076.001
]
[Cites]
Neurosurg Focus. 2003 Feb 15;14(2):e2
[
15727423.001
]
[Cites]
Clin Cancer Res. 2004 Nov 1;10(21):7182-91
[
15534091.001
]
[Cites]
Neuroradiology. 2003 Jun;45(6):373-6
[
12719953.001
]
[Cites]
J Neurosurg. 2005 Feb;102(2):267-75
[
15739554.001
]
[Cites]
Cancer. 1986 Apr 1;57(7):1276-80
[
3948112.001
]
[Cites]
J Clin Oncol. 1990 Jul;8(7):1277-80
[
2358840.001
]
[Cites]
Neoplasia. 2003 Jan-Feb;5(1):9-16
[
12659665.001
]
[Cites]
Nat Med. 1997 Dec;3(12):1362-8
[
9396606.001
]
[Cites]
J Cereb Blood Flow Metab. 1991 Sep;11(5):753-61
[
1874807.001
]
[Cites]
Neuro Oncol. 2003 Apr;5(2):79-88
[
12672279.001
]
[Cites]
Neoplasia. 2003 Jan-Feb;5(1):17-22
[
12659666.001
]
[Cites]
Stroke. 1977 Jan-Feb;8(1):51-7
[
13521.001
]
[Cites]
J Natl Cancer Inst. 1999 Aug 18;91(16):1382-90
[
10451443.001
]
[Cites]
Can J Neurol Sci. 1999 Feb;26(1):18-22
[
10068802.001
]
[Cites]
CNS Drugs. 2001;15(9):719-43
[
11580310.001
]
[Cites]
J Neurosurg. 2001 Sep;95(3):379-80
[
11565856.001
]
[Cites]
Neuroradiology. 2006 Oct;48(10):703-13
[
16937145.001
]
[Cites]
Ann Neurol. 2005 Jan;57(1):136-9
[
15622544.001
]
[Cites]
Neurosurgery. 1988 Mar;22(3):465-73
[
2452376.001
]
[Cites]
Neuro Oncol. 2001 Oct;3(4):241-5
[
11584893.001
]
[Cites]
Cancer Res. 1988 Aug 15;48(16):4489-92
[
3396000.001
]
[Cites]
Magn Reson Imaging. 2007 Apr;25(3):303-10
[
17371718.001
]
[Cites]
J Neurooncol. 2005 Jul;73(3):225-38
[
15980973.001
]
[Cites]
AJNR Am J Neuroradiol. 2006 Feb;27(2):402-8
[
16484419.001
]
[Cites]
J Nucl Med. 1998 May;39(5):786-90
[
9591575.001
]
[Cites]
Clin Cancer Res. 2004 Dec 1;10(23):7852-9
[
15585617.001
]
[Cites]
J Neurooncol. 2001 Aug;54(1):1-8
[
11763417.001
]
[Cites]
Lancet Oncol. 2008 Jan;9(1):29-38
[
18082451.001
]
[Cites]
Mutat Res. 1990 Nov-Dec;233(1-2):117-26
[
2233793.001
]
[Cites]
Acta Oncol. 1995;34(3):335-8
[
7779419.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1995 Apr 30;32(1):99-104
[
7721644.001
]
[Cites]
Lancet Oncol. 2008 May;9(5):453-61
[
18452856.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10 ):987-96
[
15758009.001
]
[Cites]
Lancet. 1995 Apr 22;345(8956):1008-12
[
7723496.001
]
(PMID = 20063175.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0Z5B2CJX4D / Fluorodeoxyglucose F18; AD84R52XLF / Thallium; U68WG3173Y / Carmustine
2.
Okada H, Lieberman FS, Walter KA, Lunsford LD, Kondziolka DS, Bejjani GK, Hamilton RL, Torres-Trejo A, Kalinski P, Cai Q, Mabold JL, Edington HD, Butterfield LH, Whiteside TL, Potter DM, Schold SC Jr, Pollack IF:
Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas.
J Transl Med
; 2007;5:67
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
METHODS: In University of Pittsburgh Cancer Institute (UPCI) protocol 95-033, adult participants with recurrent glioblastoma multiforme (GBM) or
anaplastic astrocytoma
(AA) received gross total resection (GTR) of the recurrent tumors, followed by two vaccinations with autologous fibroblasts retrovirally transfected with TFG-IL4-Neo-TK vector admixed with irradiated autologous glioma cells.
[MeSH-major]
Brain
Neoplasms / therapy. Cancer Vaccines / therapeutic use. Fibroblasts / metabolism. Glioblastoma / therapy. Interleukin-4 / genetics. Transfection
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Immunol. 2005 Jun 1;174(11):7194-201
[
15905564.001
]
[Cites]
Gene Ther. 2005 May;12(9):733-41
[
15772692.001
]
[Cites]
Neoplasia. 2005 Aug;7(8):717-22
[
16207473.001
]
[Cites]
Cancer Res. 2006 Jun 1;66(11):5883-91
[
16740728.001
]
[Cites]
Cancer Res. 2006 Apr 15;66(8):4478-87
[
16618775.001
]
[Cites]
N Engl J Med. 2006 Feb 16;354(7):709-18
[
16481638.001
]
[Cites]
J Transl Med. 2007;5:10
[
17295916.001
]
[Cites]
Cancer Res. 2007 Jul 1;67(13):6451-8
[
17616706.001
]
[Cites]
Hum Gene Ther. 2000 Mar 1;11(4):637-53
[
10724042.001
]
[Cites]
Cancer Gene Ther. 2000 Mar;7(3):486-94
[
10766355.001
]
[Cites]
J Immunol. 2000 Aug 15;165(4):1877-81
[
10925267.001
]
[Cites]
J Exp Med. 2000 Sep 18;192(6):823-33
[
10993913.001
]
[Cites]
Cancer Res. 2001 Feb 1;61(3):842-7
[
11221866.001
]
[Cites]
J Clin Oncol. 2001 Mar 15;19(6):1848-54
[
11251017.001
]
[Cites]
Hum Gene Ther. 2001 Mar 20;12(5):575-95
[
11268289.001
]
[Cites]
Gene Ther. 2001 Aug;8(15):1157-66
[
11509946.001
]
[Cites]
Nat Immunol. 2001 Nov;2(11):1054-60
[
11600887.001
]
[Cites]
Brain Res Brain Res Rev. 2003 May;42(2):97-122
[
12738053.001
]
[Cites]
Oncogene. 2003 May 19;22(20):3188-92
[
12789295.001
]
[Cites]
Blood. 2003 Jul 1;102(1):36-42
[
12560234.001
]
[Cites]
J Neurooncol. 2003 Aug-Sep;64(1-2):13-20
[
12952282.001
]
[Cites]
J Clin Oncol. 2003 Oct 15;21(20):3826-35
[
14551301.001
]
[Cites]
Curr Neurol Neurosci Rep. 2004 May;4(3):218-27
[
15102348.001
]
[Cites]
Cancer Res. 2004 Jul 15;64(14):4973-9
[
15256471.001
]
[Cites]
Cancer Res. 2004 Sep 1;64(17):5934-7
[
15342370.001
]
[Cites]
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3539-43
[
8097319.001
]
[Cites]
Hum Gene Ther. 1994 Jan;5(1):41-55
[
8155771.001
]
[Cites]
J Immunother Emphasis Tumor Immunol. 1995 May;17(4):238-48
[
7582260.001
]
[Cites]
Hum Gene Ther. 1996 Mar 1;7(4):479-87
[
8800742.001
]
[Cites]
Neurosurgery. 1996 Jun;38(6):1096-103; discussion 1103-4
[
8727138.001
]
[Cites]
J Invest Dermatol. 1998 May;110(5):762-6
[
9579542.001
]
[Cites]
Forum (Genova). 1998 Oct-Dec;8(4):357-64
[
9863030.001
]
[Cites]
Science. 1999 Feb 19;283(5405):1183-6
[
10024247.001
]
[Cites]
Gene Ther. 1999 Feb;6(2):219-26
[
10435106.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10):987-96
[
15758009.001
]
[Cites]
Clin Cancer Res. 2005 Aug 1;11(15):5515-25
[
16061868.001
]
(PMID = 18093335.001).
[ISSN]
1479-5876
[Journal-full-title]
Journal of translational medicine
[ISO-abbreviation]
J Transl Med
[Language]
eng
[Grant]
United States / NCATS NIH HHS / TR / UL1 TR000005
[Publication-type]
Clinical Trial, Phase I; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Cancer Vaccines; 207137-56-2 / Interleukin-4
[Other-IDs]
NLM/ PMC2254376
3.
Sarkar C, Karak AK, Nath N, Sharma MC, Mahapatra AK, Chattopadhyay P, Sinha S:
Apoptosis and proliferation: correlation with p53 in astrocytic tumours.
J Neurooncol
; 2005 Jun;73(2):93-100
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Here we have studied the extent of apoptosis in 62 primary human astrocytic tumours [25 Diffuse
Astrocytoma
(DA), 9
Anaplastic Astrocytoma
(AA) and 28 Glioblastoma multiforme (GBM)] in relation to tumour
grade
, proliferative status and p53 protein expression.
However this was not observed in p53 +ve GBM or in low
grade
DA either p53 positive or negative.
[MeSH-major]
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology.
Brain
Neoplasms / metabolism.
Brain
Neoplasms / pathology. Glioblastoma / metabolism. Glioblastoma / pathology. Tumor Suppressor Protein p53 / metabolism
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Bioessays. 2000 Nov;22(11):1007-17
[
11056477.001
]
[Cites]
Nature. 1997 Sep 18;389(6648):300-5
[
9305847.001
]
[Cites]
Cancer Cell. 2002 Jul;2(1):2-4
[
12150817.001
]
[Cites]
J Natl Cancer Inst. 1994 Sep 7;86(17):1286-96
[
8064887.001
]
[Cites]
Am J Pathol. 1995 Jan;146(1):3-15
[
7856735.001
]
[Cites]
Anticancer Res. 2001 Jul-Aug;21(4A):2531-5
[
11724318.001
]
[Cites]
Cancer Gene Ther. 2000 Feb;7(2):224-32
[
10770630.001
]
[Cites]
Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2026-30
[
8134344.001
]
[Cites]
J Exp Med. 1996 Sep 1;184(3):1155-60
[
9064332.001
]
[Cites]
Cell. 2000 Nov 22;103(5):691-4
[
11114324.001
]
[Cites]
Adv Cancer Res. 2000;77:81-137
[
10549356.001
]
[Cites]
Nature. 1993 Apr 29;362(6423):849-52
[
8479523.001
]
[Cites]
Neurosci Lett. 1995 Aug 4;195(2):81-4
[
7478273.001
]
[Cites]
Nat Med. 1996 May;2(5):574-7
[
8616718.001
]
[Cites]
Virchows Arch. 1995;427(2):175-9
[
7582248.001
]
[Cites]
Gen Diagn Pathol. 1996 May;141(5-6):339-44
[
8780933.001
]
[Cites]
Genes Chromosomes Cancer. 1994 Jun;10(2):143-9
[
7520269.001
]
[Cites]
Acta Neurochir (Wien). 1997;139(9):845-50
[
9351989.001
]
[Cites]
J Clin Oncol. 2003 Jul 1;21(13):2508-18
[
12839017.001
]
[Cites]
Lancet. 1993 May 15;341(8855):1251-4
[
8098400.001
]
[Cites]
Brain Pathol. 1998 Oct;8(4):599-613
[
9804370.001
]
[Cites]
Br J Cancer. 1997;75(9):1269-78
[
9155045.001
]
[Cites]
J Cell Biol. 1999 Jan 25;144(2):281-92
[
9922454.001
]
[Cites]
Cancer Genet Cytogenet. 2003 Jul 15;144(2):156-64
[
12850379.001
]
[Cites]
Brain Tumor Pathol. 1999;16(1):11-6
[
10532418.001
]
[Cites]
Oncol Rep. 2002 Jul-Aug;9(4):703-7
[
12066196.001
]
[Cites]
Mol Carcinog. 1997 Feb;18(2):66-77
[
9049182.001
]
[Cites]
Oncogene. 1994 Jun;9(6):1799-805
[
8183579.001
]
[Cites]
Neuro Oncol. 1999 Apr;1(2):124-37
[
11550308.001
]
[Cites]
Curr Neurol Neurosci Rep. 2002 May;2(3):246-53
[
11937003.001
]
[Cites]
Cell. 1997 Feb 7;88(3):323-31
[
9039259.001
]
[Cites]
Cancer Res. 1995 Mar 1;55(5):999-1001
[
7867012.001
]
[Cites]
Science. 1995 Mar 10;267(5203):1456-62
[
7878464.001
]
[Cites]
Mol Cell Biol. 2001 Feb;21(4):1297-310
[
11158315.001
]
[Cites]
Neuropathol Appl Neurobiol. 1995 Aug;21(4):352-61
[
7494604.001
]
[Cites]
Cell. 1994 Aug 26;78(4):703-11
[
8069917.001
]
[Cites]
Blood. 1993 Jul 1;82(1):15-21
[
8324219.001
]
[Cites]
EMBO J. 2000 Sep 15;19(18):4967-75
[
10990460.001
]
[Cites]
Brain Pathol. 1996 Jul;6(3):217-23; discussion 23-4
[
8864278.001
]
[Cites]
J Pathol. 1994 Aug;173(4):333-9
[
7965393.001
]
[Cites]
Nat Genet. 2000 Sep;26(1):37-43
[
10973245.001
]
[Cites]
Genes Dev. 1994 Dec 1;8(23):2817-30
[
7995520.001
]
[Cites]
Cancer Res. 1991 Jun 1;51(11):2979-84
[
2032235.001
]
[Cites]
Science. 1994 Sep 30;265(5181):2091-3
[
8091232.001
]
[Cites]
Acta Neuropathol. 1996;91(1):112-6
[
8773155.001
]
[Cites]
Br J Neurosurg. 2002 Aug;16(4):335-42
[
12389885.001
]
[Cites]
J Neuropathol Exp Neurol. 1998 Aug;57(8):746-57
[
9720490.001
]
[Cites]
J Neurooncol. 2002 Jan;56(1):21-8
[
11949823.001
]
[Cites]
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5006-10
[
2052583.001
]
[Cites]
Cancer Res. 1992 Mar 1;52(5):1342-6
[
1737395.001
]
[Cites]
J Neurooncol. 2000;46(3):215-29
[
10902853.001
]
[Cites]
J Neuropathol Exp Neurol. 1993 Jan;52(1):31-8
[
8381161.001
]
[Cites]
Lab Invest. 1995 Dec;73(6):837-43
[
8558845.001
]
[Cites]
Cancer Res. 1991 Dec 1;51(23 Pt 1):6304-11
[
1933891.001
]
[Cites]
Pathology. 2000 May;32(2):84-8
[
10840825.001
]
[Cites]
Genes Dev. 1995 Sep 1;9(17):2170-83
[
7657168.001
]
[Cites]
Cell Death Differ. 2000 Jun;7(6):511-20
[
10822274.001
]
[Cites]
J Neurooncol. 2003 Jun;63(2):129-45
[
12825817.001
]
[Cites]
Clin Cancer Res. 2002 May;8(5):1117-24
[
12006527.001
]
[Cites]
Mutat Res. 2002 Mar;511(1):45-62
[
11906841.001
]
[Cites]
Neoplasma. 2000;47(3):151-5
[
11043837.001
]
[Cites]
J Gastroenterol Hepatol. 2002 Sep;17(9):966-72
[
12167117.001
]
[Cites]
Gene Ther. 2001 Mar;8(6):469-76
[
11313826.001
]
[Cites]
Mol Cell Biol. 1995 Jun;15(6):3032-40
[
7539102.001
]
[Cites]
Cancer. 1997 Jul 15;80(2):242-9
[
9217037.001
]
[Cites]
J Pathol. 1999 Jan;187(1):112-26
[
10341712.001
]
[Cites]
J Neurooncol. 1999;44(3):255-66
[
10720205.001
]
[Cites]
J Neurooncol. 2002 Apr;57(2):105-14
[
12125970.001
]
[Cites]
Arch Pathol Lab Med. 2000 Jan;124(1):108-13
[
10629140.001
]
[Cites]
Oncogene. 2003 Sep 1;22(37):5774-83
[
12947385.001
]
[Cites]
Br J Cancer. 1993 Feb;67(2):205-8
[
8431353.001
]
[Cites]
J Neurooncol. 2002 Jun;58(2):157-65
[
12164688.001
]
[Cites]
Oncology. 2003;64(4):459-67
[
12759546.001
]
[Cites]
Clin Cancer Res. 2002 Jul;8(7):2024-34
[
12114400.001
]
[Cites]
Oncogene. 1997 Aug 14;15(7):871-4
[
9266974.001
]
[Cites]
Cytometry. 2000 Oct 1;41(2):83-8
[
11002262.001
]
[Cites]
Neuro Oncol. 2000 Apr;2(2):96-102
[
11303626.001
]
[Cites]
Clin Neuropathol. 1996 Nov-Dec;15(6):337-41
[
8937780.001
]
[Cites]
Int J Cancer. 1993 Dec 2;55(6):982-7
[
8253536.001
]
[Cites]
J Neuropathol Exp Neurol. 1994 Jan;53(1):11-21
[
8301315.001
]
[Cites]
Brain Pathol. 1993 Jul;3(3):229-35
[
8293182.001
]
(PMID = 15981097.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Tumor Suppressor Protein p53
Advertisement
4.
Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S:
FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells.
Cancer Res
; 2008 Nov 1;68(21):8733-42
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
We previously found that FoxM1B is overexpressed in human glioblastomas and that forced FoxM1B expression in
anaplastic astrocytoma
cells leads to the formation of highly angiogenic glioblastoma in nude mice.
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Neurosurg. 2000 Feb;92(2):326-33
[
10659021.001
]
[Cites]
Genes Dev. 2008 Feb 15;22(4):449-62
[
18258752.001
]
[Cites]
Cancer Res. 2000 Oct 15;60(20):5879-86
[
11059786.001
]
[Cites]
Cancer Res. 2001 May 15;61(10):4143-54
[
11358838.001
]
[Cites]
Genes Dev. 2001 Jun 1;15(11):1311-33
[
11390353.001
]
[Cites]
Cancer Res. 2001 Sep 15;61(18):6885-91
[
11559565.001
]
[Cites]
J Neuropathol Exp Neurol. 2002 Mar;61(3):215-25; discussion 226-9
[
11895036.001
]
[Cites]
Oncogene. 2002 Mar 27;21(13):2058-65
[
11960378.001
]
[Cites]
Am J Pathol. 2002 Jul;161(1):125-34
[
12107097.001
]
[Cites]
Oncogene. 2002 Dec 5;21(55):8404-13
[
12466961.001
]
[Cites]
Am J Pathol. 2003 Sep;163(3):1033-43
[
12937144.001
]
[Cites]
Semin Cancer Biol. 2004 Apr;14(2):123-30
[
15018896.001
]
[Cites]
Genes Dev. 2004 Apr 1;18(7):830-50
[
15082532.001
]
[Cites]
BMC Cancer. 2003 Sep 17;3:23
[
13678425.001
]
[Cites]
Lab Invest. 2004 Aug;84(8):941-51
[
15184909.001
]
[Cites]
Cytokine Growth Factor Rev. 2004 Oct;15(5):297-324
[
15450248.001
]
[Cites]
Nature. 1992 Oct 29;359(6398):843-5
[
1279431.001
]
[Cites]
Brain Pathol. 1993 Jul;3(3):255-68
[
8293185.001
]
[Cites]
J Neuropathol Exp Neurol. 1994 Jan;53(1):11-21
[
8301315.001
]
[Cites]
J Biol Chem. 1995 Jun 2;270(22):13333-40
[
7768934.001
]
[Cites]
Circ Res. 1995 Sep;77(3):638-43
[
7641334.001
]
[Cites]
Mol Cell Biol. 1995 Oct;15(10):5363-8
[
7565686.001
]
[Cites]
Nat Med. 1995 Jan;1(1):27-31
[
7584949.001
]
[Cites]
Pediatr Neurosurg. 1996;24(1):41-9
[
8817614.001
]
[Cites]
J Biol Chem. 1996 Nov 8;271(45):28220-8
[
8910439.001
]
[Cites]
Mol Cell Biol. 1997 Mar;17(3):1626-41
[
9032290.001
]
[Cites]
Nucleic Acids Res. 1997 May 1;25(9):1715-9
[
9108152.001
]
[Cites]
J Biol Chem. 1997 Aug 8;272(32):19827-36
[
9242644.001
]
[Cites]
Cancer Res. 1997 Sep 1;57(17):3860-4
[
9288800.001
]
[Cites]
Mol Biol Cell. 1998 Feb;9(2):469-81
[
9450968.001
]
[Cites]
Mod Pathol. 1998 Feb;11(2):155-68
[
9504686.001
]
[Cites]
Int J Cancer. 1999 Mar 31;81(1):118-24
[
10077162.001
]
[Cites]
Science. 1999 Apr 30;284(5415):808-12
[
10221914.001
]
[Cites]
Curr Opin Oncol. 1999 May;11(3):162-7
[
10328589.001
]
[Cites]
Nat Cell Biol. 2005 Feb;7(2):126-36
[
15654331.001
]
[Cites]
Cancer Res. 2005 Mar 15;65(6):2065-9
[
15781613.001
]
[Cites]
Int J Cancer. 2005 Jun 10;115(2):202-13
[
15688401.001
]
[Cites]
Neuro Oncol. 2005 Apr;7(2):134-53
[
15831232.001
]
[Cites]
Cancer Res. 2005 May 15;65(10):4051-8
[
15899794.001
]
[Cites]
J Biol Chem. 2005 Jun 10;280(23):22278-86
[
15817462.001
]
[Cites]
Cancer Res. 2005 Jun 15;65(12):5181-9
[
15958562.001
]
[Cites]
Cancer Res. 2006 Feb 1;66(3):1712-20
[
16452231.001
]
[Cites]
Cancer Res. 2006 Feb 15;66(4):2153-61
[
16489016.001
]
[Cites]
Cancer Res. 2006 Apr 1;66(7):3593-602
[
16585184.001
]
[Cites]
J Neuropathol Exp Neurol. 2006 Jun;65(6):529-39
[
16783163.001
]
[Cites]
Gastroenterology. 2007 Apr;132(4):1420-31
[
17408638.001
]
[Cites]
Cancer Res. 2007 Sep 1;67(17):8293-300
[
17804744.001
]
[Cites]
Oncogene. 2007 Sep 13;26(42):6212-9
[
17404569.001
]
[Cites]
Clin Cancer Res. 2000 Jun;6(6):2562-72
[
10873113.001
]
(PMID = 18974115.001).
[ISSN]
1538-7445
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA-16672; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / R01 CA116528-03; United States / NCI NIH HHS / CA / CA116528-03; United States / NCI NIH HHS / CA / R01-CA-116528; United States / NCI NIH HHS / CA / R01 CA116528; United States / NCI NIH HHS / CA / R01 CA116528-02; United States / NCI NIH HHS / CA / CA116528-02
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA Primers; 0 / FOXM1 protein, human; 0 / Forkhead Transcription Factors; 0 / Vascular Endothelial Growth Factor A
[Other-IDs]
NLM/ NIHMS67455; NLM/ PMC2597644
5.
Baehring J, Hui P, Piepmeier J, Bannykh SI:
Anaplastic oligoastrocytoma in Turcot syndrome.
J Neurooncol
; 2009 Nov;95(2):293-298
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Anaplastic
oligoastrocytoma in Turcot syndrome.
Turcot syndrome (TS), a rare variant of hereditary non-polyposis colorectal cancer (HNPCC), is characterized by familial clustering of cancer of the large bowel, extracolonic body sites and
brain
.
We report a 72 year old woman with
anaplastic
oligoastrocytoma in the setting of TS.
Careful analysis of tumor DNA is required to exclude the chance occurrence of a
brain
tumor in HNPCC kindreds and increase our understanding of the pathogenesis of the disease.
[MeSH-major]
Astrocytoma
/ complications. Colorectal Neoplasms, Hereditary Nonpolyposis / complications
Genetic Alliance.
consumer health - Anaplastic Oligoastrocytoma
.
Genetic Alliance.
consumer health - Oligoastrocytoma
.
Genetic Alliance.
consumer health - Turcot syndrome
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Science. 1997 Feb 14;275(5302):967-9
[
9020077.001
]
[Cites]
J Mol Diagn. 2000 Feb;2(1):20-8
[
11272898.001
]
[Cites]
Genes Chromosomes Cancer. 1999 Jun;25(2):75-81
[
10337989.001
]
[Cites]
Gastroenterology. 1993 May;104(5):1535-49
[
8482467.001
]
[Cites]
Genomics. 1994 Dec;24(3):516-26
[
7713503.001
]
[Cites]
Nat Genet. 1996 Nov;14(3):255-7
[
8896552.001
]
[Cites]
Nature. 1996 Aug 8;382(6591):499-500
[
8700220.001
]
[Cites]
J Natl Cancer Inst. 2004 Feb 18;96(4):261-8
[
14970275.001
]
[Cites]
Nature. 1994 Sep 1;371(6492):75-80
[
8072530.001
]
[Cites]
Cell. 1993 Dec 3;75(5):1027-38
[
8252616.001
]
[Cites]
Int J Cancer. 1996 Feb 8;65(4):422-5
[
8621220.001
]
[Cites]
Nature. 1993 Jun 10;363(6429):558-61
[
8505985.001
]
[Cites]
N Engl J Med. 1996 Mar 14;334(11):736-7
[
8594446.001
]
[Cites]
N Engl J Med. 1995 Mar 30;332(13):839-47
[
7661930.001
]
[Cites]
Jpn J Clin Oncol. 2002 Jun;32(6):215-8
[
12110639.001
]
[Cites]
Dis Colon Rectum. 1959 Sep-Oct;2:465-8
[
13839882.001
]
[Cites]
Hum Mol Genet. 2000 Jan 22;9(2):283-7
[
10607839.001
]
[Cites]
Science. 1995 Jun 2;268(5215):1336-8
[
7761852.001
]
[Cites]
Nervenarzt. 2002 Feb;73(2):177-82
[
11975096.001
]
[Cites]
J Neurosurg. 1999 May;90(5):946-50
[
10223463.001
]
[Cites]
Int J Cancer. 1995 Dec 20;64(6):430-3
[
8550246.001
]
[Cites]
Nat Genet. 1999 Oct;23(2):142-4
[
10508506.001
]
[Cites]
J Med Genet. 1995 Nov;32(11):909-12
[
8592341.001
]
[Cites]
Nature. 1994 Mar 17;368(6468):258-61
[
8145827.001
]
[Cites]
Oncogene. 1997 Dec 4;15(23):2877-81
[
9419979.001
]
(PMID = 19495563.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.1.- / PMS2 protein, human; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / Mismatch Repair Endonuclease PMS2; EC 3.6.1.3 / MutL Protein Homolog 1; EC 3.6.1.3 / MutS Homolog 2 Protein; EC 6.5.1.- / DNA Repair Enzymes
6.
Zhang K, Li C, Liu Y, Li L, Ma X, Meng X, Feng D:
Evaluation of invasiveness of astrocytoma using 1H-magnetic resonance spectroscopy: correlation with expression of matrix metalloproteinase-2.
Neuroradiology
; 2007 Nov;49(11):913-9
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Evaluation of invasiveness
of astrocytoma
using 1H-magnetic resonance spectroscopy: correlation with expression of matrix metalloproteinase-2.
INTRODUCTION: Even low-
grade
astrocytomas infiltrate the entire
brain
, a feature that precludes their successful therapy.
So to assess the invasive potential
of astrocytoma
is very important.
The aim of this study was determine whether there is a significant correlation between the results of (1)H-magnetic resonance spectroscopy ((1)H-MRS) and tumor invasive potential
of astrocytoma
, which is reflected by expression of matrix metalloproteinase-2 (MMP-2).
According to the World Health Organization classification criteria for central nervous system tumors, there were 16 low-
grade
astrocytomas (2 pilocytic astrocytomas, 14
grade
II astrocytomas) and 25 high-
grade
astrocytomas (5
anaplastic
astrocytomas, 20 glioblastomas).The choline/N-acetylaspartate (Cho/NAA) and choline/creatine (Cho/Cr) ratios were calculated.
Of the 41 astrocytomas, 19 (8 low-
grade
and 11 high-
grade
) were analyzed immunohistochemically.
RESULTS: The Cho/NAA and Cho/Cr ratios of high-
grade
astrocytoma
were both significantly greater than those of low-
grade
astrocytoma
(t = -6.222, P = 0.000; t = -6.533, P = 0.000, respectively).
MMP-2 COD values of high-
grade
astrocytomas were also significantly greater than those of low-
grade
astrocytomas (t = -5.892, P = 0.000).
[MeSH-major]
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology.
Brain
Neoplasms / metabolism.
Brain
Neoplasms / pathology. Magnetic Resonance Spectroscopy. Matrix Metalloproteinase 2 / metabolism
MedlinePlus Health Information.
consumer health - Brain Tumors
.
Hazardous Substances Data Bank.
(L)-ASPARTIC ACID
.
Hazardous Substances Data Bank.
CREATINE
.
Hazardous Substances Data Bank.
CHOLINE CHLORIDE
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14
[
11994741.001
]
[Cites]
Int J Dev Neurosci. 1999 Aug-Oct;17(5-6):495-502
[
10571411.001
]
[Cites]
Neuroradiology. 2006 May;48(5):312-8
[
16552583.001
]
[Cites]
Radiology. 2006 Mar;238(3):958-69
[
16424238.001
]
[Cites]
Pharmacol Res. 2002 Aug;46(2):155-63
[
12220955.001
]
[Cites]
J Neurooncol. 2000 Dec;50(3):215-26
[
11263501.001
]
[Cites]
NMR Biomed. 2004 Feb;17(1):10-20
[
15011246.001
]
[Cites]
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8904-9
[
12861074.001
]
[Cites]
AJNR Am J Neuroradiol. 1999 Jan;20(1):117-23
[
9974066.001
]
[Cites]
Br J Cancer. 2000 Jan;82(1):52-5
[
10638966.001
]
[Cites]
J Neurooncol. 2003 Jul;63(3):233-45
[
12892229.001
]
[Cites]
Stereotact Funct Neurosurg. 2004;82(2-3):90-7
[
15305081.001
]
[Cites]
Am J Pathol. 1998 Aug;153(2):429-37
[
9708803.001
]
[Cites]
Neuroradiology. 2002 May;44(5):371-81
[
12012120.001
]
[Cites]
AJNR Am J Neuroradiol. 2001 Apr;22(4):604-12
[
11290466.001
]
[Cites]
Nat Rev Neurosci. 2001 Jul;2(7):502-11
[
11433375.001
]
[Cites]
AJNR Am J Neuroradiol. 2000 Apr;21(4):659-65
[
10782774.001
]
[Cites]
AJNR Am J Neuroradiol. 2002 Nov-Dec;23 (10 ):1775-8
[
12427638.001
]
(PMID = 17763847.001).
[ISSN]
0028-3940
[Journal-full-title]
Neuroradiology
[ISO-abbreviation]
Neuroradiology
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; EC 3.4.24.24 / Matrix Metalloproteinase 2; MU72812GK0 / Creatine; N91BDP6H0X / Choline
7.
McNatt SA, Gonzalez-Gomez I, Nelson MD, McComb JG:
Synchronous multicentric pleomorphic xanthoastrocytoma: case report.
Neurosurgery
; 2005 Jul;57(1):E191; discussion E191
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
OBJECTIVE AND IMPORTANCE: Pleomorphic xanthoastrocytoma (PXA) is a rare, low-
grade
astrocytoma of
adolescence.
Results of the histological examination were consistent with a
diagnosis
of PXA.
The patient was treated with whole-
brain
radiation of 3600 cGy, with additional intensity-modulated boosts to the enhancing lesions of 1440 cGy.
CONCLUSION: Synchronous multicentric PXA presents unique challenges in that gross total resection would impose significant surgical morbidity; histological homogeneity among the lesions cannot be confirmed; and the well-described potential for
anaplastic
transformation may be increased with multiple lesions.
The optimal treatment for patients with this rare and challenging
diagnosis
awaits further study.
[MeSH-major]
Astrocytoma
.
Brain
Neoplasms. Neoplasms, Multiple Primary
Genetic Alliance.
consumer health - Pleomorphic xanthoastrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 15987556.001).
[ISSN]
1524-4040
[Journal-full-title]
Neurosurgery
[ISO-abbreviation]
Neurosurgery
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
8.
Iun'pén V, Oliushin VE, Ulitin AIu, Maslova LN, Petrov AA:
[Long-term results of treatment in patients with oligodendrogliomas and oligoastrocytomas of the cerebral hemispheres].
Zh Vopr Neirokhir Im N N Burdenko
; 2008 Apr-Jun;(2):6-10; discussion 10-1
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
RESULTS: After complex therapy, the mean survival was 80.6 months in patients with oligodendrogliomas, 63.3 months in those with
anaplastic
oligoastrocytomas, and 42 months in those with
anaplastic
oligodendrogliomas.
[MeSH-major]
Astrocytoma
/ therapy.
Brain
Neoplasms / therapy. Oligodendroglioma / therapy
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18720725.001).
[ISSN]
0042-8817
[Journal-full-title]
Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
[ISO-abbreviation]
Zh Vopr Neirokhir Im N N Burdenko
[Language]
rus
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Russia (Federation)
9.
Phuphanich S, Carson KA, Grossman SA, Lesser G, Olson J, Mikkelsen T, Desideri S, Fisher JD, New Approaches to Brain Tumor Therapy (NABTT) CNS Consortium:
Phase I safety study of escalating doses of atrasentan in adults with recurrent malignant glioma.
Neuro Oncol
; 2008 Aug;10(4):617-23
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Twenty-two patients had glioblastoma multiforme (GBM), 2 had
anaplastic astrocytoma
, and 1 had an
anaplastic
oliogodendroglioma; 24 patients had received one prior chemo therapy regimen before being enrolled in the study.
The most common atrasentan-related toxicities were
grade
1 or 2 rhinitis, fatigue, and edema.
One patient developed
grade
3 hypoxia and peripheral edema at a dose of 90 mg/day.
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Neuro Oncol. 2006 Jan;8(1):27-37
[
16443945.001
]
[Cites]
J Clin Oncol. 1999 Aug;17(8):2572-8
[
10561324.001
]
[Cites]
Br J Clin Pharmacol. 2000 Jun;49(6):562-73
[
10848720.001
]
[Cites]
Br J Cancer. 2000 Sep;83(5):588-93
[
10944597.001
]
[Cites]
Br J Clin Pharmacol. 2002 Apr;53(4):355-62
[
11966665.001
]
[Cites]
J Biol Chem. 2002 Aug 2;277(31):27850-5
[
12023962.001
]
[Cites]
Nat Rev Drug Discov. 2002 Dec;1(12):986-1001
[
12461520.001
]
[Cites]
Nat Rev Cancer. 2003 Feb;3(2):110-6
[
12563310.001
]
[Cites]
J Clin Oncol. 2003 Feb 15;21(4):679-89
[
12586806.001
]
[Cites]
Cancer Res. 2003 Mar 1;63(5):906-11
[
12615701.001
]
[Cites]
Clin Cancer Res. 2003 Aug 1;9(8):2965-72
[
12912943.001
]
[Cites]
Clin Cancer Res. 2004 Jul 1;10(13):4406-11
[
15240529.001
]
[Cites]
Cancer Chemother Rep. 1974 Nov-Dec;58(6):787-92
[
4447922.001
]
[Cites]
N Engl J Med. 1980 Dec 4;303(23):1323-9
[
7001230.001
]
[Cites]
Peptides. 1993 Mar-Apr;14(2):385-99
[
8483816.001
]
[Cites]
J Neurochem. 1994 Dec;63(6):2240-7
[
7964744.001
]
[Cites]
J Cardiovasc Pharmacol. 1995;26 Suppl 3:S408-11
[
8587429.001
]
[Cites]
J Pharmacol Exp Ther. 1996 Feb;276(2):473-81
[
8632312.001
]
[Cites]
Biochim Biophys Acta. 1996 May 28;1311(3):155-63
[
8664342.001
]
[Cites]
J Neuropathol Exp Neurol. 1997 Apr;56(4):435-9
[
9100674.001
]
[Cites]
N Engl J Med. 1998 Mar 19;338(12):784-90
[
9504938.001
]
[Cites]
Ann Neurol. 1998 Oct;44(4):691-5
[
9778271.001
]
[Cites]
Circulation. 1998 Nov 24;98(21):2262-8
[
9826312.001
]
[Cites]
Neuro Oncol. 2005 Jan;7(1):32-40
[
15701280.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10):987-96
[
15758009.001
]
(PMID = 18477765.001).
[ISSN]
1522-8517
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / U01 CA062406; United States / NCI NIH HHS / CA / U01 CA062475; United States / NCI NIH HHS / CA / U01-CA62406; United States / NCI NIH HHS / CA / UO1 CA-62475
[Publication-type]
Case Reports; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Pyrrolidines; V6D7VK2215 / atrasentan
[Other-IDs]
NLM/ PMC2666236
10.
Hartmann C, Hentschel B, Wick W, Capper D, Felsberg J, Simon M, Westphal M, Schackert G, Meyermann R, Pietsch T, Reifenberger G, Weller M, Loeffler M, von Deimling A:
Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas.
Acta Neuropathol
; 2010 Dec;120(6):707-18
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Patients with IDH1 wild type
anaplastic
astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas.
WHO grading of human
brain
tumors extends beyond a strictly histological grading system by providing a basis predictive for the clinical behavior of the respective neoplasm.
For example, patients with glioblastoma WHO
grade
IV usually show a less favorable clinical course and receive more aggressive first-line treatment than patients with
anaplastic astrocytoma
WHO
grade III
.
Here we provide evidence that the IDH1 status is more prognostic for overall survival than standard histological criteria that differentiate high-
grade
astrocytomas.
We sequenced the isocitrate dehydrogenase 1 gene (IDH1) at codon 132 in 382 patients with
anaplastic astrocytoma
and glioblastoma from the NOA-04 trial and from a prospective translational cohort study of the German Glioma Network.
Patients with
anaplastic
astrocytomas carried IDH1 mutations in 60%, and patients with glioblastomas in 7.2%.
IDH1 was the most prominent single prognostic factor (RR 2.7; 95% CI 1.6-4.5) followed by age,
diagnosis
and MGMT.
The sequence from more favorable to poorer outcome was (1)
anaplastic astrocytoma
with IDH1 mutation, (2) glioblastoma with IDH1 mutation, (3)
anaplastic astrocytoma
without IDH1 mutation and (4) glioblastoma without IDH1 mutation (p < 0.0001).
In this combined set
of anaplastic
astrocytomas and glioblastomas both, IDH1 mutation and IDH1 expression status were of greater prognostic relevance than histological
diagnosis
according to the current WHO classification system.
We propose to complement the current WHO classification and grading of high-
grade
astrocytic gliomas by the IDH1 mutation status and to use this combined histological and molecular classification in future clinical trials.
[MeSH-major]
Brain
Neoplasms / genetics. Glioblastoma / genetics. Glioma / classification. Glioma / genetics. Isocitrate Dehydrogenase / genetics. Mutation / genetics
[MeSH-minor]
Adolescent. Adult. Age Factors. Aged. Aged, 80 and over.
Astrocytoma
/
diagnosis
.
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Cohort Studies. Female. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Young Adult
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
Faculty of 1000.
commentaries/discussion - See the articles recommended by F1000Prime's Faculty of more than 8,000 leading experts in Biology and Medicine.
(subscription/membership/fee required).
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 21088844.001).
[ISSN]
1432-0533
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42. / IDH1 protein, human
11.
Freitas MR, de Muzio SD, Pessoa RC, Stávale JN, Borges LR, Malheiros SM:
[Diffuse bone marrow metastasis in cerebellar high-grade astrocytoma. A case report].
Rev Neurol
; 2009 Mar 1-15;48(5):242-4
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
[Diffuse bone marrow metastasis in cerebellar high-
grade
astrocytoma
. A case report].
[Transliterated title]
Metastasis difusa
de
la medula osea en un
astrocitoma
cerebeloso
de
alto grado. Un caso clinico.
INTRODUCTION: Cerebellar high-
grade
astrocytoma
is uncommon.
CASE REPORT: A 46 year-old man with cerebellar
anaplastic astrocytoma
who developed pancytopenia due to extensive bone marrow metastases.
CONCLUSION: Extraneural metastases
of brain
gliomas are rare and the spread to the bone marrow confers an extremely poor prognosis for these patients.
[MeSH-major]
Astrocytoma
/ pathology. Bone Marrow Neoplasms / secondary. Cerebellar Neoplasms / pathology
Genetic Alliance.
consumer health - Diffuse Astrocytoma
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19263392.001).
[ISSN]
1576-6578
[Journal-full-title]
Revista de neurologia
[ISO-abbreviation]
Rev Neurol
[Language]
spa
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Spain
12.
Oshiro S, Tsugu H, Komatsu F, Abe H, Onishi H, Ohmura T, Iwaasa M, Sakamoto S, Fukushima T:
Quantitative assessment of gliomas by proton magnetic resonance spectroscopy.
Anticancer Res
; 2007 Nov-Dec;27(6A):3757-63
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
PATIENTS AND METHODS: Eight patients with histologically verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM,
grade
4), 5 cases with
anaplastic
oligodendroglioma (AO,
grade
3; high-
grade
glioma), and 1 case with fibrillary
astrocytoma
(FA,
grade
2; low-
grade
glioma) were evaluated using the 1H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively.
RESULTS: High-
grade
gliomas tended to demonstrate signal hyperintensity by DWI and higher relative cerebral blood volume (rCBV) by PWI.
The presence of lactate and lipid was predominately detected in patients with high-
grade
glioma.
[MeSH-major]
Brain
Neoplasms /
diagnosis
. Glioma /
diagnosis
. Magnetic Resonance Spectroscopy
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17970039.001).
[ISSN]
0250-7005
[Journal-full-title]
Anticancer research
[ISO-abbreviation]
Anticancer Res.
[Language]
eng
[Publication-type]
Comparative Study; Evaluation Studies; Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
0 / Protons
13.
Hariharan S, Donahue JE, Garre C, Origone P, Grewal RP:
Clinicopathologic and genetic analysis of siblings with NF1 and adult-onset gliomas.
J Neurol Sci
; 2006 Aug 15;247(1):105-8
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
BACKGROUND: Neurofibromatosis Type 1 (NF1) is a common autosomal dominant neurogenetic
disorder
characterized by neoplasms involving the nervous system which typically present in children.
A biopsy was performed and pathological examination revealed an
anaplastic
pleomorphic xanthoastrocytoma (PXA).
Although she did not meet the accepted clinical criteria for NF1, given that she has a sibling with NF1 and a malignancy observed in this
disorder
, we hypothesize that she also has NF1.
Our genetic analysis indicated a shared haplotype in these siblings who developed
brain
tumors but not in an unaffected sister suggesting that both carry the NF1 disease-producing allele.
CONCLUSION: NF1 should be a diagnostic consideration when siblings develop intracranial
brain
tumors even when they develop in adults.
[MeSH-major]
Astrocytoma
/ genetics.
Brain
Neoplasms / genetics. Neurofibromatosis 1 / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16725158.001).
[ISSN]
0022-510X
[Journal-full-title]
Journal of the neurological sciences
[ISO-abbreviation]
J. Neurol. Sci.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
14.
Glanz C, Rebetz J, Stewénius Y, Persson A, Englund E, Mandahl N, Mertens F, Salford LG, Widegren B, Fan X, Gisselsson D:
Genetic intratumour heterogeneity in high-grade brain tumours is associated with telomere-dependent mitotic instability.
Neuropathol Appl Neurobiol
; 2007 Aug;33(4):440-54
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Genetic intratumour heterogeneity in high-
grade
brain
tumours is associated with telomere-dependent mitotic instability.
Glioblastoma multiforme (GBM) and other high-
grade
brain
tumours are typically characterized by complex chromosome abnormalities and extensive intratumour cytogenetic heterogeneity.
In this study, we analysed the pattern of chromosome segregation at mitosis in 20
brain
tumours.
Anaphase bridging was also found in two medulloblastomas (7-15%), one
anaplastic astrocytoma
(17%) and one oligodendroglioma (6%).
In contrast, cell division abnormalities were not found in low-
grade
brain
tumours with less complex karyotypes, including two pilocytic astrocytomas and two ependymomas.
Telomere-dependent abnormal segregation of chromosomes at mitosis is thus a common phenomenon in high-
grade
brain
tumours and may be one important factor behind cytogenetic intratumour diversity in GBM.
[MeSH-major]
Brain
Neoplasms / genetics.
Brain
Neoplasms / pathology. Spindle Apparatus / pathology. Telomere / pathology
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17617873.001).
[ISSN]
0305-1846
[Journal-full-title]
Neuropathology and applied neurobiology
[ISO-abbreviation]
Neuropathol. Appl. Neurobiol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
EC 2.7.7.49 / Telomerase
15.
Voelzke WR, Petty WJ, Lesser GJ:
Targeting the epidermal growth factor receptor in high-grade astrocytomas.
Curr Treat Options Oncol
; 2008 Feb;9(1):23-31
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Targeting the epidermal growth factor receptor in high-
grade
astrocytomas.
OPINION STATEMENT: High-
grade
astrocytomas, including glioblastoma multiforme (GBM) and
anaplastic astrocytoma
(AA), are the most common and aggressive primary malignant
brain
tumors in adults.
[MeSH-major]
Astrocytoma
/ drug therapy.
Brain
Neoplasms / drug therapy. Protein Kinase Inhibitors / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Cancer Lett. 2003 Dec 8;202(1):43-51
[
14643025.001
]
[Cites]
Clin Cancer Res. 2006 Sep 1;12(17):5064-73
[
16951222.001
]
[Cites]
Neurology. 2005 Apr 26;64(8):1444-5
[
15851741.001
]
[Cites]
Neurosurgery. 2002 Oct;51(4):1005-13; discussion 1013-4
[
12234411.001
]
[Cites]
Oncogene. 2000 Dec 27;19(56):6550-65
[
11426640.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):873-82
[
17544000.001
]
[Cites]
Cancer Res. 2003 Oct 15;63(20):6962-70
[
14583498.001
]
[Cites]
J Cell Biochem. 2007 Nov 1;102(4):869-77
[
17868090.001
]
[Cites]
N Engl J Med. 2005 Nov 10;353(19):2012-24
[
16282176.001
]
[Cites]
J Clin Oncol. 2005 Dec 1;23(34):8757-64
[
16314636.001
]
[Cites]
Int J Cancer. 2002 Oct 20;101(6):567-75
[
12237899.001
]
[Cites]
J Clin Oncol. 2004 Jan 1;22(1):133-42
[
14638850.001
]
[Cites]
Neuro Oncol. 2006 Jan;8(1):67-78
[
16443950.001
]
[Cites]
Clin Cancer Res. 1996 Dec;2(12):1931-5
[
9816151.001
]
[Cites]
Clin Cancer Res. 2002 Nov;8(11):3496-502
[
12429640.001
]
[Cites]
Science. 2004 Jun 4;304(5676):1497-500
[
15118125.001
]
[Cites]
N Engl J Med. 2004 May 20;350(21):2129-39
[
15118073.001
]
[Cites]
Cancer Biol Ther. 2006 Apr;5(4):375-9
[
16575203.001
]
[Cites]
BMC Cancer. 2006 May 18;6:133
[
16709245.001
]
[Cites]
Clin Cancer Res. 2003 Sep 15;9(11):4247-54
[
14519652.001
]
[Cites]
J Clin Invest. 2007 Feb;117(2):346-52
[
17256054.001
]
[Cites]
Mol Cancer Ther. 2007 Mar;6(3):1167-74
[
17363510.001
]
[Cites]
Neurosurgery. 2005;56(1):155-62; discussion 162
[
15617598.001
]
[Cites]
Cancer Res. 1997 Nov 1;57(21):4838-48
[
9354447.001
]
[Cites]
Clin Cancer Res. 2001 Aug;7(8):2387-95
[
11489817.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10 ):997-1003
[
15758010.001
]
[Cites]
Cancer Res. 2000 Mar 1;60(5):1383-7
[
10728703.001
]
[Cites]
Cancer Res. 2003 Dec 15;63(24):8930-8
[
14695210.001
]
[Cites]
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4071-6
[
17360479.001
]
[Cites]
Cancer Res. 2007 Sep 1;67(17 ):7960-5
[
17804702.001
]
[Cites]
Crit Rev Oncol Hematol. 2006 Dec;60(3):181-93
[
16875833.001
]
[Cites]
Clin Cancer Res. 2005 Nov 1;11(21):7841-50
[
16278407.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10 ):987-96
[
15758009.001
]
[Cites]
CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
[
17237035.001
]
(PMID = 18247132.001).
[ISSN]
1534-6277
[Journal-full-title]
Current treatment options in oncology
[ISO-abbreviation]
Curr Treat Options Oncol
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Protein Kinase Inhibitors; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
[Number-of-references]
54
16.
Yue WY, Chen ZP:
Does vasculogenic mimicry exist in astrocytoma?
J Histochem Cytochem
; 2005 Aug;53(8):997-1002
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Does vasculogenic mimicry exist in
astrocytoma
?
It is unknown whether a similar VM phenomenon exists in
astrocytoma
.
The present study was to examine 45 astrocytomas (including World Health Organization
grade
II 15 cases,
grade III
15 cases, and
grade
IV 15 cases) by CD34 endothelial marker periodic acid-Schiff (PAS) dual staining to see if VM existing in these tumors.
PAS-positive pattern of VM was found in two
grade
IV astrocytomas.
Furthermore, in
astrocytoma
, especially glioblastoma, focus
of anaplastic
tumor cells appeared with CD34 expression, whereas some tumor cells lost glial fibrillary acid protein expression.
It is assumed that genetically deregulated tumor cells in
astrocytoma
could lose the astrocyte-specific protein and express inappropriate markers not expected in cells of astrocyte lineage.
The present results suggest that VM phenomenon exists in some malignant
astrocytoma
.
[MeSH-major]
Astrocytoma
/ blood supply.
Brain
Neoplasms / blood supply
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 15923371.001).
[ISSN]
0022-1554
[Journal-full-title]
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
[ISO-abbreviation]
J. Histochem. Cytochem.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, CD34; 0 / Biomarkers; 0 / Coloring Agents; 0 / Schiff Bases; 10450-60-9 / Periodic Acid
17.
Marie Y, Carpentier AF, Omuro AM, Sanson M, Thillet J, Hoang-Xuan K, Delattre JY:
EGFR tyrosine kinase domain mutations in human gliomas.
Neurology
; 2005 Apr 26;64(8):1444-5
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
In this study, the authors tested the presence of such mutations in 95 gliomas including glioblastomas,
anaplastic
oligodendrogliomas, and low-
grade
gliomas.
[MeSH-major]
Brain
Neoplasms / enzymology.
Brain
Neoplasms / genetics. Glioma / enzymology. Glioma / genetics. Mutation / genetics. Receptor, Epidermal Growth Factor / genetics
[MeSH-minor]
Astrocytoma
/ drug therapy.
Astrocytoma
/ enzymology.
Astrocytoma
/ genetics. Carcinoma / drug therapy. Carcinoma / enzymology. Carcinoma / genetics. DNA Mutational Analysis. Drug Resistance, Neoplasm / genetics. Genetic Testing. Glioblastoma / drug therapy. Glioblastoma / enzymology. Glioblastoma / genetics. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / enzymology. Lung Neoplasms / genetics. Oligodendroglioma / drug therapy. Oligodendroglioma / enzymology. Oligodendroglioma / genetics. Protein Kinase Inhibitors / pharmacology. Protein Kinase Inhibitors / therapeutic use. Protein Structure, Tertiary / genetics. Quinazolines / pharmacology. Quinazolines / therapeutic use
MedlinePlus Health Information.
consumer health - Brain Tumors
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
SciCrunch.
OMIM: Data: Gene Annotation
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 15851741.001).
[ISSN]
1526-632X
[Journal-full-title]
Neurology
[ISO-abbreviation]
Neurology
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Protein Kinase Inhibitors; 0 / Quinazolines; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
18.
Radulović D:
[Natural history of supratentorial low-grade astrocytoma: case report].
Srp Arh Celok Lek
; 2006 Nov-Dec;134(11-12):537-40
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
[Natural history of supratentorial low-
grade
astrocytoma
: case report].
Low-
grade
astrocytomas comprise a group of primary
brain
neoplasms with relatively low
anaplastic
potential, although through time they tend to behave more aggressively.
This report presents a natural history of a patient with low
grade
astrocytoma
.
Initial computerized tomography and magnetic resonance
of brain
revealed oval, 4 cm in diameter, lesion in the left parietal region that was considered as low-
grade
glioma.
The described patient with low-
grade
astrocytoma
lived without any oncological treatment eight years and four months from the time when
diagnosis
was made until intracranial herniation.
The natural history of disease in presented patient indicated that rational therapeutic strategy, for low-
grade
astrocytoma
with epilepsy only, would be deferral of surgery until the time of manifestation of neurological or radiological deterioration.
[MeSH-major]
Astrocytoma
.
Brain
Neoplasms. Parietal Lobe
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17304770.001).
[ISSN]
0370-8179
[Journal-full-title]
Srpski arhiv za celokupno lekarstvo
[ISO-abbreviation]
Srp Arh Celok Lek
[Language]
srp
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Serbia and Montenegro
19.
Niizuma K, Fujimura M, Kumabe T, Tominaga T:
Malignant transformation of high-grade astrocytoma associated with neurocysticercosis in a patient with Turcot syndrome.
J Clin Neurosci
; 2007 Jan;14(1):53-5
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Malignant transformation of high-
grade
astrocytoma
associated with neurocysticercosis in a patient with Turcot syndrome.
A 45-year-old woman with
anaplastic astrocytoma
was clinically diagnosed with Turcot syndrome, and subsequently developed simultaneous neurocysticercosis and malignant transformation to glioblastoma.
Histological examination of surgical specimens revealed neurocysticercosis between the normal
brain
tissue and glioblastoma.
[MeSH-major]
Astrocytoma
/ pathology.
Brain
Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Glioblastoma / pathology. Neurocysticercosis / pathology
Genetic Alliance.
consumer health - Turcot syndrome
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17138070.001).
[ISSN]
0967-5868
[Journal-full-title]
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
[ISO-abbreviation]
J Clin Neurosci
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Scotland
20.
Narayana A, Yamada J, Berry S, Shah P, Hunt M, Gutin PH, Leibel SA:
Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results.
Int J Radiat Oncol Biol Phys
; 2006 Mar 1;64(3):892-7
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Intensity-modulated radiotherapy in high-
grade
gliomas: clinical and dosimetric results.
METHODS AND MATERIALS: Fifty-eight consecutive high-
grade
gliomas were treated between January 2001 and December 2003 with dynamic multileaf collimator IMRT, planned with the inverse approach.
Glioblastoma accounted for 70% of the cases, and
anaplastic
oligodendroglioma histology (pure or mixed) was seen in 15% of the cases.
The median progression-free survival time for
anaplastic astrocytoma
and glioblastoma histology was 5.6 and 2.5 months, respectively.
The overall survival time for
anaplastic
glioma and glioblastoma was 36 and 9 months, respectively.
No
Grade
IV/V late neurologic toxicities were noted.
Intensity-modulated radiotherapy delivered with a limited number of beams did not result in an increased dose to the normal
brain
.
CONCLUSIONS: It is unlikely that IMRT will improve local control in high-
grade
gliomas without further dose escalation compared with conventional radiotherapy.
[MeSH-major]
Brain
Neoplasms / radiotherapy. Glioma / radiotherapy. Radiotherapy, Intensity-Modulated
[MeSH-minor]
Adult. Aged. Aged, 80 and over.
Brain
/ radiation effects. Disease Progression. Female. Glioblastoma / radiotherapy. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Oligodendroglioma / radiotherapy. Radiotherapy Dosage. Retrospective Studies
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16458777.001).
[ISSN]
0360-3016
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
United States
21.
Horbinski C, Wang G, Wiley CA:
YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas.
Int J Clin Exp Pathol
; 2010 Jan 01;3(3):226-37
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
YKL-40 is a secreted chitinase-like molecule whose expression is associated with glioma
grade
.
A rank-order list of YKL-40 expression was determined immunohistochemically in 79 untreated high-
grade
adult glio-mas, including 28
anaplastic
oligodendrogliomas (AOs) and 51 GBMs.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Neuro Oncol. 1999 Jan;1(1):44-51
[
11550301.001
]
[Cites]
Oncogene. 2009 Dec 17;28(50):4456-68
[
19767768.001
]
[Cites]
N Engl J Med. 2002 Feb 7;346(6):420-7
[
11832530.001
]
[Cites]
Biochem J. 2002 Jul 1;365(Pt 1):119-26
[
12071845.001
]
[Cites]
Cancer. 2002 Jul 15;95(2):267-74
[
12124825.001
]
[Cites]
Cancer Res. 2002 Aug 1;62(15):4364-8
[
12154041.001
]
[Cites]
Int J Cancer. 2002 Oct 10;101(5):454-60
[
12216074.001
]
[Cites]
J Neurosurg. 2002 Dec;97(6):1397-401
[
12507139.001
]
[Cites]
Clin Cancer Res. 2003 Oct 1;9(12):4423-34
[
14555515.001
]
[Cites]
Biochem J. 2004 Jun 15;380(Pt 3):651-9
[
15015934.001
]
[Cites]
Cancer Res. 1997 Jan 15;57(2):304-9
[
9000573.001
]
[Cites]
Cancer Res. 2005 Mar 1;65(5):1678-86
[
15753362.001
]
[Cites]
Cancer Sci. 2005 Mar;96(3):183-90
[
15771622.001
]
[Cites]
Clin Cancer Res. 2005 Mar 15;11(6):2258-64
[
15788675.001
]
[Cites]
Clin Cancer Res. 2005 May 1;11(9):3326-34
[
15867231.001
]
[Cites]
J Neuropathol Exp Neurol. 2005 Jun;64(6):479-89
[
15977639.001
]
[Cites]
Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8644-52
[
16361549.001
]
[Cites]
Neurosurg Focus. 2005 Nov;19(5):E2
[
16398466.001
]
[Cites]
Cancer. 2006 Mar 1;106(5):1130-9
[
16456816.001
]
[Cites]
Clin Cancer Res. 2006 Jul 1;12(13):3935-41
[
16818690.001
]
[Cites]
J Biol Chem. 2006 Oct 6;281(40):29583-96
[
16882657.001
]
[Cites]
J Neuropathol Exp Neurol. 2006 Dec;65(12):1149-56
[
17146289.001
]
[Cites]
Gynecol Oncol. 2007 Feb;104(2):435-42
[
17023034.001
]
[Cites]
World J Surg Oncol. 2007;5:17
[
17286869.001
]
[Cites]
Clin Cancer Res. 2007 Mar 1;13(5):1429-37
[
17332285.001
]
[Cites]
J Clin Oncol. 2007 Jun 1;25(16):2288-94
[
17538175.001
]
[Cites]
Clin Cancer Res. 2007 Jun 1;13(11):3244-9
[
17545529.001
]
[Cites]
Int J Cancer. 2008 Feb 15;122(4):857-63
[
17957792.001
]
[Cites]
Urol Oncol. 2008 Jan-Feb;26(1):47-52
[
18190830.001
]
[Cites]
Eur J Haematol. 2008 Apr;80(4):310-7
[
18182077.001
]
[Cites]
Int J Cancer. 2008 May 15;122(10):2187-98
[
18092325.001
]
[Cites]
Am J Pathol. 2008 Jul;173(1):130-43
[
18556781.001
]
[Cites]
Adv Ther. 2008 Aug;25(8):801-9
[
18670741.001
]
[Cites]
FEBS Lett. 2008 Sep 22;582(21-22):3193-200
[
18708058.001
]
[Cites]
Oncogene. 2008 Nov 6;27(52):6679-89
[
18724390.001
]
[Cites]
Ann Oncol. 2009 Jan;20(1):71-7
[
18723551.001
]
[Cites]
J Clin Oncol. 2009 Feb 1;27(4):572-8
[
19075264.001
]
[Cites]
BMC Cancer. 2009;9:8
[
19134206.001
]
[Cites]
Brain Pathol. 2009 Jul;19(3):439-48
[
18652591.001
]
[Cites]
Biochem Biophys Res Commun. 2009 Oct 23;388(3):511-6
[
19666003.001
]
[Cites]
Hum Pathol. 2009 Dec;40(12):1790-7
[
19765801.001
]
[Cites]
Clin Cancer Res. 2002 Jan;8(1):196-201
[
11801559.001
]
(PMID = 20224722.001).
[ISSN]
1936-2625
[Journal-full-title]
International journal of clinical and experimental pathology
[ISO-abbreviation]
Int J Clin Exp Pathol
[Language]
ENG
[Grant]
United States / NIMH NIH HHS / MH / K24 MH001717; United States / PHS HHS / / K24 M401717
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Adipokines; 0 / CHI3L1 protein, human; 0 / Glycoproteins; 0 / Lectins; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
[Other-IDs]
NLM/ PMC2836500
[Keywords]
NOTNLM ; 10q / 1p19q / EGFR / YKL-40 / glioblastoma / oligodendroglioma
22.
Korshunov A, Meyer J, Capper D, Christians A, Remke M, Witt H, Pfister S, von Deimling A, Hartmann C:
Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.
Acta Neuropathol
; 2009 Sep;118(3):401-5
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic
astrocytoma
from diffuse
astrocytoma
.
Separation of pilocytic
astrocytoma
from diffuse astrocytomas frequently poses problems mostly related to small sample size.
Precise classification and grading are essential due to different therapeutic strategies prompted by diagnoses of pilocytic
astrocytoma
WHO
grade
I, diffuse astrocytomas WHO
grade
II or
anaplastic astrocytoma
WHO
grade III
.
We examined a series of 120 astrocytomas including 70 pilocytic astrocytomas WHO
grade
I and 50 diffuse astrocytomas WHO
grade
II for both, BRAF-KIAA1549 fusion with a newly developed FISH assay and mutations in IDH1 and IDH2 by direct sequencing.
Astrocytomas WHO
grade
II exhibited IDH1 mutations in 38 cases (76%) but neither IDH2 mutations nor BRAF fusions.
Thus, combined molecular analysis of BRAF and IDH1 is a sensitive and highly specific approach to separate pilocytic
astrocytoma
from diffuse
astrocytoma
.
[MeSH-major]
Astrocytoma
/
diagnosis
.
Brain
Neoplasms /
diagnosis
. Isocitrate Dehydrogenase / genetics. Proto-Oncogene Proteins B-raf / genetics
[MeSH-minor]
Adolescent. Adult. Aged. Biomarkers, Tumor. Child. Child, Preschool.
Diagnosis
, Differential. Female. Humans. In Situ Hybridization, Fluorescence. Male. Middle Aged. Mutation. Tissue Array Analysis
Genetic Alliance.
consumer health - Diffuse Astrocytoma
.
Genetic Alliance.
consumer health - Pilocytic astrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19543740.001).
[ISSN]
1432-0533
[Journal-full-title]
Acta neuropathologica
[ISO-abbreviation]
Acta Neuropathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Biomarkers, Tumor; EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42 / isocitrate dehydrogenase (NADP+); EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
23.
Korones DN, Smith A, Foreman N, Bouffet E:
Temozolomide and oral VP-16 for children and young adults with recurrent or treatment-induced malignant gliomas.
Pediatr Blood Cancer
; 2006 Jul;47(1):37-41
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Diagnoses included recurrent
brain
stem glioma (2), recurrent
anaplastic astrocytoma
(2), and glioblastoma (7) (3 treatment-induced, 2 malignant transformations of lower
grade
tumors, 1 recurrence, and 1 second tumor arising 10 months after
diagnosis
of medulloblastoma).
There was one
grade
4 neutropenia, but no other
grade
3 or 4 toxicities.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
ETOPOSIDE
.
Hazardous Substances Data Bank.
DACARBAZINE
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Copyright]
Copyright 2006 Wiley-Liss, Inc.
(PMID = 16047359.001).
[ISSN]
1545-5009
[Journal-full-title]
Pediatric blood & cancer
[ISO-abbreviation]
Pediatr Blood Cancer
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
24.
Adamek D, Dec M, Sobol G, Urbanowicz B, Jaworski M:
Giant cell ependymoma: a case report.
Clin Neurol Neurosurg
; 2008 Feb;110(2):176-81
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Histological, immunohistochemical and electron microscopic findings were consistent with high-
grade
ependymoma.
As a result the
diagnosis
of GCE was established.
This type of neoplasm necessitates, at least in theory, differentiation with
anaplastic
oligodendroglioma, clear cell ependymoma, pleomorphic xanthoastrocytoma, giant cell glioblastoma, and subependymal giant cell
astrocytoma
.
[MeSH-major]
Brain
Neoplasms / pathology. Ependymoma / pathology. Lateral Ventricles
Genetic Alliance.
consumer health - Ependymoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18006220.001).
[ISSN]
0303-8467
[Journal-full-title]
Clinical neurology and neurosurgery
[ISO-abbreviation]
Clin Neurol Neurosurg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Netherlands
25.
Wacker A, Will BE, Schöning M, Neunhoeffer F:
[Intracerebral bleeding as the first symptom of a congenital anaplastic astrocytoma].
Z Geburtshilfe Neonatol
; 2008 Oct;212(5):194-6
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
[Intracerebral bleeding as the first symptom of a congenital
anaplastic astrocytoma
].
BACKGROUND:
Anaplastic
astrocytomas in neonates are extremely rare.
An ultrasound scan of the
brain
showed an intracerebral bleeding.
No tumour was found, but an
anaplastic astrocytoma
(WHO
Grade III
) was diagnosed histologically.
Serial ultrasound investigations of the
brain
showed a normal midline and a redevelopment of the left-sided ventricle.
CONCLUSION: Congenital
anaplastic
astrocytomas have a variable outcome, with different survival rates as compared to adults.
[MeSH-major]
Astrocytoma
/ congenital.
Brain
Neoplasms / congenital. Cerebral Hemorrhage / congenital
[MeSH-minor]
Diagnosis
, Differential. Echoencephalography. Fatal Outcome. Female. Humans. Infant, Newborn. Magnetic Resonance Imaging. Occipital Lobe / pathology. Temporal Lobe / pathology. Tomography, X-Ray Computed. Trephining
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18956278.001).
[ISSN]
0948-2393
[Journal-full-title]
Zeitschrift für Geburtshilfe und Neonatologie
[ISO-abbreviation]
Z Geburtshilfe Neonatol
[Language]
ger
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Germany
26.
Quon H, Abdulkarim B:
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas.
Cochrane Database Syst Rev
; 2008;(2):CD007104
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Adjuvant treatment
of anaplastic
oligodendrogliomas and oligoastrocytomas.
Outcomes analyzed include overall survival (OS), progression-free survival (PFS), and treatment toxicity greater than or equal to
grade
3.
Based on the differences in patient selection with respect to the definition of AO (2 versus 3 high risk
anaplastic
features) and sequence of treatment (RT and chemotherapy), the results from the two RCTs were not able to be considered for meta-analysis.
[MeSH-major]
Astrocytoma
/ drug therapy.
Brain
Neoplasms / drug therapy. Oligodendroglioma / drug therapy
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[UpdateIn]
Cochrane Database Syst Rev. 2014;5:CD007104
[
24833028.001
]
(PMID = 18425979.001).
[ISSN]
1469-493X
[Journal-full-title]
The Cochrane database of systematic reviews
[ISO-abbreviation]
Cochrane Database Syst Rev
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Number-of-references]
11
27.
Limentani SA, Asher A, Heafner M, Kim JW, Fraser R:
A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme.
J Neurooncol
; 2005 May;72(3):241-4
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary
anaplastic astrocytoma
or glioblastoma multiforme.
The purpose of this study was to evaluate combination chemotherapy with Gliadel wafer and carboplatin in patients with high-
grade
, malignant glioma.
Fourteen (88%) patients had glioblastoma multiforme and 2 (12%) had
anaplastic astrocytoma
.
No
grade
3 or 4 toxicities were noted in this study.
[MeSH-major]
Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ drug therapy.
Astrocytoma
/ radiotherapy.
Brain
Neoplasms / drug therapy.
Brain
Neoplasms / radiotherapy. Carboplatin / therapeutic use. Decanoic Acids / therapeutic use. Glioblastoma / drug therapy. Glioblastoma / radiotherapy. Polyesters / therapeutic use
Genetic Alliance.
consumer health - Glioblastoma
.
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Cancer Chemotherapy
.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
Carmustine
.
Hazardous Substances Data Bank.
CARBOPLATIN
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Curr Opin Neurol. 2000 Dec;13(6):619-25
[
11148660.001
]
[Cites]
J Clin Oncol. 2001 Jan 15;19(2):509-18
[
11208845.001
]
[Cites]
Neurosurgery. 1997 Jul;41(1):44-8; discussion 48-9
[
9218294.001
]
[Cites]
Ann Neurol. 1998 Oct;44(4):691-5
[
9778271.001
]
[Cites]
Neurosurgery. 1992 Feb;30(2):223-7
[
1312230.001
]
[Cites]
Neuro Oncol. 2003 Apr;5(2):79-88
[
12672279.001
]
[Cites]
Cancer Res. 1998 Feb 15;58(4):672-84
[
9485020.001
]
[Cites]
J Neurosurg. 1992 May;76(5):772-81
[
1564540.001
]
[Cites]
Neuro Oncol. 2001 Oct;3(4):246-50
[
11584894.001
]
[Cites]
Cancer. 1993 Apr 15;71(8):2585-97
[
8453582.001
]
[Cites]
Cancer Chemother Pharmacol. 1997;39(4):376-9
[
9025780.001
]
[Cites]
J Control Release. 1999 Aug 27;61(1-2):21-41
[
10469900.001
]
[Cites]
Lancet. 1995 Apr 22;345(8956):1008-12
[
7723496.001
]
(PMID = 15937647.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Decanoic Acids; 0 / Drug Implants; 0 / Polyesters; 90409-78-2 / decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer; BG3F62OND5 / Carboplatin; U68WG3173Y / Carmustine
28.
Hunter SB, Varma V, Shehata B, Nolen JD, Cohen C, Olson JJ, Ou CY:
Apolipoprotein D expression in primary brain tumors: analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue.
J Histochem Cytochem
; 2005 Aug;53(8):963-9
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Apolipoprotein D expression in primary
brain
tumors: analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue.
ApoD expression was investigated by real-time quantitative RT-PCR using RNA extracted from 68 formalin-fixed, paraffin-embedded
brain
specimens.
Sixteen poorly infiltrating WHO
grade
I glial neoplasms (i.e., pilocytic astrocytomas and gangliogliomas) showed an average 20-fold higher apoD expression level compared with the 20 diffusely infiltrating glial neoplasms (i.e., glioblastoma,
anaplastic astrocytoma
, oligodendrogliomas; p=0.00004).
Analyzed as individual tumor groups, poorly infiltrating
grade
I pilocytic astrocytomas and gangliogliomas differed significantly from each tumor type within the diffusely infiltrating higher-
grade
category (p<0.05 for each comparison) but not from each other (p>0.05).
Ependymomas, non-infiltrating
grade
II neoplasms, expressed levels of apoD similar to or lower than levels expressed by the diffusely infiltrating gliomas.
In addition, apoD expression was 5-fold higher in the slowly proliferating
grade
I glial neoplasms compared with non-proliferating normal
brain
tissue (p=0.01), suggesting that apoD expression is not simply an inverse measure of proliferation.
ApoD expression measured by quantitative RT-PCR may be useful in the differential
diagnosis
of primary
brain
tumors, particularly pilocytic astrocytomas and gangliogliomas.
[MeSH-major]
Apolipoproteins / biosynthesis.
Brain
Neoplasms / metabolism. Glioma / metabolism
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
FORMALDEHYDE
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16055749.001).
[ISSN]
0022-1554
[Journal-full-title]
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
[ISO-abbreviation]
J. Histochem. Cytochem.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Apolipoproteins; 0 / Apolipoproteins D; 0 / Fixatives; 0 / Ki-67 Antigen; 1HG84L3525 / Formaldehyde; 8002-74-2 / Paraffin
29.
Takei H, Powell SZ:
Rosenthal fiber-rich glioblastoma: a case report.
Clin Neuropathol
; 2009 May-Jun;28(3):168-72
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Although the presence of abundant RFs within
brain
tumors is most closely associated with a low-
grade
astrocytoma
, particularly pilocytic
astrocytoma
(PA), a few RFs are recognized to occur, although rarely, in glioblastoma (GBM).
Histologic sections showed diffusely infiltrating
astrocytoma
with prominent RFs diffusely distributed throughout the tumor, brisk mitotic activity, vascular proliferation, and small areas of necrosis, as seen in a GBM.
DISCUSSION: This is a case of RF-rich GBM (primary or
de
novo type).
The differential
diagnosis
includes PA and
anaplastic
PA.
For the histological
diagnosis
, infiltrating
astrocytoma
with abundant RFs should be carefully examined in light of clinical information (e.g., patient age, evolution of the symptoms) and neuroimaging studies.
[MeSH-major]
Astrocytes / pathology.
Brain
Neoplasms / pathology. Glioblastoma / pathology
Genetic Alliance.
consumer health - Glioblastoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19537132.001).
[ISSN]
0722-5091
[Journal-full-title]
Clinical neuropathology
[ISO-abbreviation]
Clin. Neuropathol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Germany
30.
Quaranta M, Divella R, Daniele A, Di Tardo S, Venneri MT, Lolli I, Troccoli G:
Epidermal growth factor receptor serum levels and prognostic value in malignant gliomas.
Tumori
; 2007 May-Jun;93(3):275-80
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
The aim of this study was to estimate the EGFR serum concentration for potential use as a biological marker
of brain
cancer to predict prognosis and follow-up after treatment.
METHODS AND STUDY DESIGN: Serum samples obtained from 50 healthy individuals and 65
brain
cancer patients (35 glioblastoma multiforme and 30
anaplastic
astrocytomas) were collected before and after treatment and assayed for EGFR extracellular domain serum concentrations by a sandwich ELISA.
RESULTS: EGFR was elevated in 47 of 65
brain
cancer patients, with mean serum values of 84 +/- 18 ng/ml, compared with that of healthy controls (43.6 +/- 11 ng/ml, P = 0.001).
There was a significant difference in the mean serum levels of EGFR between glioblastoma multiforme patients (96.2 +/- 12 ng/ml) and
anaplastic astrocytoma
patients (71.6 +/- 18 ng/ml, P = 0.04).
Sixty
brain
cancer patients underwent surgery; EGFR serum levels did not show significant differences from those observed before surgery.
For all patients, median overall survival was 13 months (
anaplastic astrocytoma
, 18 months; glioblastoma multiforme, 12.5 months).
In 47 patients with high EGFR serum levels, overall survival was reduced (P = 0.01), with a median survival time corresponding to 11.5 months (
anaplastic astrocytoma
, 14.5 months; glioblastoma multiforme, 10.5 months).
[MeSH-major]
Biomarkers, Tumor / blood.
Brain
Neoplasms / blood. Glioma / blood. Neoplasm Proteins / blood. Receptor, Epidermal Growth Factor / blood
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ blood.
Astrocytoma
/ drug therapy.
Astrocytoma
/ mortality.
Astrocytoma
/ radiotherapy.
Astrocytoma
/ surgery. Chemotherapy, Adjuvant. Combined Modality Therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Disease-Free Survival. Enzyme-Linked Immunosorbent Assay. Female. Follow-Up Studies. Glioblastoma / blood. Glioblastoma / drug therapy. Glioblastoma / mortality. Glioblastoma / radiotherapy. Glioblastoma / surgery. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Protein Structure, Tertiary. Radiotherapy, Adjuvant. Signal Transduction. Survival Analysis. Treatment Outcome
MedlinePlus Health Information.
consumer health - Brain Tumors
.
Hazardous Substances Data Bank.
DACARBAZINE
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17679463.001).
[ISSN]
0300-8916
[Journal-full-title]
Tumori
[ISO-abbreviation]
Tumori
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 7GR28W0FJI / Dacarbazine; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; YF1K15M17Y / temozolomide
31.
Gulati S, Ytterhus B, Granli US, Gulati M, Lydersen S, Torp SH:
Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas.
Diagn Pathol
; 2010;5:18
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Overexpression of c-erbB2 is a negative prognostic factor in
anaplastic
astrocytomas.
The aim of this study was to investigate EGFR gene amplification and expression of c-erbB1-4 receptor proteins in human
anaplastic
astrocytomas.
The synchronous overexpression of c-erbB1-4 proteins in
anaplastic
astrocytomas supports their role in the pathogenesis of these tumors.
[MeSH-major]
Astrocytoma
/ chemistry. Biomarkers, Tumor / analysis. Receptor, ErbB-2 / analysis. Supratentorial Neoplasms / chemistry
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Mol Pharmacol. 2008 Feb;73(2):338-48
[
17975007.001
]
[Cites]
J Neurooncol. 2007 Dec;85(3):281-7
[
17571214.001
]
[Cites]
J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):215-23
[
18454306.001
]
[Cites]
J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):259-68
[
18454307.001
]
[Cites]
Curr Treat Options Oncol. 2008 Feb;9(1):23-31
[
18247132.001
]
[Cites]
Exp Cell Res. 2008 Oct 1;314(16):2907-18
[
18687326.001
]
[Cites]
Minim Invasive Neurosurg. 2009 Feb;52(1):17-24
[
19247900.001
]
[Cites]
Appl Immunohistochem Mol Morphol. 2009 May;17(3):220-6
[
19391220.001
]
[Cites]
J Natl Cancer Inst. 2009 May 20;101(10):736-50
[
19436038.001
]
[Cites]
Brain Pathol. 2009 Oct;19(4):713-23
[
19744042.001
]
[Cites]
Cancer. 2002 Mar 1;94(5):1593-611
[
11920518.001
]
[Cites]
Acta Neurochir (Wien). 2000;142(2):113-37; discussion 137-8
[
10795886.001
]
[Cites]
Cell. 2000 Oct 13;103(2):211-25
[
11057895.001
]
[Cites]
Endocr Relat Cancer. 2001 Jun;8(2):83-96
[
11397666.001
]
[Cites]
J Natl Cancer Inst. 2001 Aug 15;93(16):1246-56
[
11504770.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):410-8
[
11567815.001
]
[Cites]
Cell. 2002 Sep 20;110(6):669-72
[
12297041.001
]
[Cites]
Front Biosci. 2003 Jan 1;8:e1-13
[
12456322.001
]
[Cites]
Brain Pathol. 2003 Jan;13(1):52-61
[
12580545.001
]
[Cites]
Am J Clin Oncol. 2003 Aug;26(4):332-5
[
12902879.001
]
[Cites]
Cancer Res. 2003 Oct 15;63(20):6962-70
[
14583498.001
]
[Cites]
Semin Oncol. 2003 Dec;30(6 Suppl 19):10-4
[
14765378.001
]
[Cites]
Diagn Mol Pathol. 2004 Mar;13(1):1-8
[
15163002.001
]
[Cites]
Acta Neuropathol. 2004 Aug;108(2):135-42
[
15148612.001
]
[Cites]
J Neuropathol Exp Neurol. 2004 Jul;63(7):700-7
[
15290895.001
]
[Cites]
Nature. 1985 Jan 10-18;313(5998):144-7
[
2981413.001
]
[Cites]
Proc Natl Acad Sci U S A. 1987 Oct;84(19):6899-903
[
3477813.001
]
[Cites]
Virchows Arch A Pathol Anat Histopathol. 1989;414(2):147-55
[
2563600.001
]
[Cites]
Science. 1989 May 12;244(4905):707-12
[
2470152.001
]
[Cites]
J Biol Chem. 1991 Jan 25;266(3):1716-20
[
1671042.001
]
[Cites]
Cancer Res. 1991 Apr 15;51(8):2164-72
[
2009534.001
]
[Cites]
Cancer Immunol Immunother. 1991;33(1):61-4
[
2021959.001
]
[Cites]
J Neuropathol Exp Neurol. 1992 Jan;51(1):84-90
[
1311022.001
]
[Cites]
J Neurosurg. 1992 Aug;77(2):295-301
[
1320666.001
]
[Cites]
Acta Neurochir (Wien). 1992;117(3-4):182-6
[
1414519.001
]
[Cites]
Eur J Cancer. 1993;29A(11):1604-6
[
8105841.001
]
[Cites]
Int J Cancer. 1994 Jan 2;56(1):72-7
[
8262681.001
]
[Cites]
Hum Pathol. 1994 Aug;25(8):772-80
[
7914508.001
]
[Cites]
J Neurooncol. 1994;22(3):201-7
[
7760096.001
]
[Cites]
Clin Neuropathol. 1995 May-Jun;14(3):169-74
[
7671460.001
]
[Cites]
Neurosurgery. 1995 Aug;37(2):179-93; discussion 193-4
[
7477768.001
]
[Cites]
Br J Cancer. 1996 Mar;73(5):620-3
[
8605096.001
]
[Cites]
Am J Pathol. 1996 Apr;148(4):1047-53
[
8644846.001
]
[Cites]
EMBO J. 1997 Apr 1;16(7):1647-55
[
9130710.001
]
[Cites]
Cancer Res. 1997 Aug 1;57(15):3272-80
[
9242460.001
]
[Cites]
J Neurooncol. 1997 Dec;35(3):335-46
[
9440030.001
]
[Cites]
Clin Cancer Res. 1998 Jan;4(1):215-22
[
9516974.001
]
[Cites]
J Pathol. 1998 Jul;185(3):236-45
[
9771476.001
]
[Cites]
Brain Pathol. 1998 Oct;8(4):655-67
[
9804374.001
]
[Cites]
Neuropathol Appl Neurobiol. 1998 Oct;24(5):381-8
[
9821169.001
]
[Cites]
J Neuropathol Exp Neurol. 1998 Dec;57(12):1138-45
[
9862636.001
]
[Cites]
Cancer Invest. 2004;22(4):537-44
[
15565811.001
]
[Cites]
JAMA. 2005 Feb 2;293(5):557-64
[
15687310.001
]
[Cites]
J Exp Clin Cancer Res. 2005 Mar;24(1):89-92
[
15943037.001
]
[Cites]
Endocr Relat Cancer. 2005 Jul;12 Suppl 1:S17-27
[
16113093.001
]
[Cites]
Appl Immunohistochem Mol Morphol. 2006 Mar;14(1):91-6
[
16540738.001
]
[Cites]
Cancer Treat Rev. 2006 Apr;32(2):74-89
[
16488082.001
]
[Cites]
Neuropathol Appl Neurobiol. 2006 Aug;32(4):441-50
[
16866989.001
]
[Cites]
Appl Immunohistochem Mol Morphol. 2007 Mar;15(1):56-8
[
17536308.001
]
[Cites]
Crit Rev Oncol Hematol. 2007 Jul;63(1):72-80
[
17478095.001
]
[Cites]
J Exp Clin Cancer Res. 2007 Sep;26(3):353-9
[
17987795.001
]
[Cites]
Mol Pharmacol. 2008 Feb;73(2):271-3
[
17981994.001
]
(PMID = 20331873.001).
[ISSN]
1746-1596
[Journal-full-title]
Diagnostic pathology
[ISO-abbreviation]
Diagn Pathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / ERBB4 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.10.1 / Receptor, ErbB-4
[Other-IDs]
NLM/ PMC2859381
[General-notes]
NLM/ Original DateCompleted: 20100609
32.
Stupp R, Reni M, Gatta G, Mazza E, Vecht C:
Anaplastic astrocytoma in adults.
Crit Rev Oncol Hematol
; 2007 Jul;63(1):72-80
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Anaplastic astrocytoma
in adults.
Anaplastic astrocytoma
is an uncommon disease in the adult population.
Based on randomized data available, chemotherapy has consistently failed to improve the outcome of patients with
anaplastic astrocytoma
, while a meta-analysis showed a small, but significant improvement in survival favouring the use of chemotherapy.
In recurrent disease, chemotherapy with temozolomide has been proven to be active and well-tolerated in phase II trials, but no comparative phase
III
trials of other cytotoxic drugs have been conducted.
[MeSH-major]
Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ drug therapy.
Brain
Neoplasms / drug therapy. Dacarbazine / analogs & derivatives
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
The Weizmann Institute of Science GeneCards and MalaCards databases.
gene/protein/disease-specific - MalaCards for anaplastic astrocytoma
.
Hazardous Substances Data Bank.
DACARBAZINE
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17478095.001).
[ISSN]
1040-8428
[Journal-full-title]
Critical reviews in oncology/hematology
[ISO-abbreviation]
Crit. Rev. Oncol. Hematol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Review
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
[Number-of-references]
69
33.
Stege EM, Kros JM, de Bruin HG, Enting RH, van Heuvel I, Looijenga LH, van der Rijt CD, Smitt PA, van den Bent MJ:
Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine.
Cancer
; 2005 Feb 15;103(4):802-9
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Successful treatment of low-
grade
oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine.
BACKGROUND:
Anaplastic
oligodendroglioma (OD) tumors, especially those with the combined loss of the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q), are sensitive to chemotherapy.
Only limited data are available on the role of chemotherapy in low-
grade
OD.
The authors retrospectively studied the outcome of the procarbazine, lomustine, and vincristine (PCV) chemotherapy regimen in a group of 16 patients with newly diagnosed OD and 5 patients with recurrent low-
grade
OD.
A Phase
III
trial should be initiated to compare radiotherapy with chemotherapy.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Astrocytoma
/ drug therapy.
Brain
Neoplasms / drug therapy. Oligodendroglioma / drug therapy
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
LOMUSTINE
.
Hazardous Substances Data Bank.
VINCRISTINE
.
Hazardous Substances Data Bank.
PROCARBAZINE
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Copyright]
Copyright (c) 2005 American Cancer Society.
(PMID = 15637687.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Tumor Suppressor Protein p53; 35S93Y190K / Procarbazine; 5J49Q6B70F / Vincristine; 7BRF0Z81KG / Lomustine
34.
Finlay JL, Dhall G, Boyett JM, Dunkel IJ, Gardner SL, Goldman S, Yates AJ, Rosenblum MK, Stanley P, Zimmerman RA, Wallace D, Pollack IF, Packer RJ, Children's Cancer Group:
Myeloablative chemotherapy with autologous bone marrow rescue in children and adolescents with recurrent malignant astrocytoma: outcome compared with conventional chemotherapy: a report from the Children's Oncology Group.
Pediatr Blood Cancer
; 2008 Dec;51(6):806-11
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Myeloablative chemotherapy with autologous bone marrow rescue in children and adolescents with recurrent malignant
astrocytoma
: outcome compared with conventional chemotherapy: a report from the Children's Oncology Group.
METHODS: Twenty-seven children and adolescents with malignant astrocytomas [17 glioblastoma multiforme and 10
anaplastic astrocytoma
(AA)] following initial tumor progression, received myeloablative chemotherapy followed by autologous marrow rescue with one of three thiotepa and etoposide-based chemotherapy regimens, administered alone (n = 11) or combined with carmustine (n = 5) or carboplatin (n = 11).
The two cohorts were compared for age, histology, prior therapies, extent of surgical resection at progression, and time from initial
diagnosis
to progression.
Of 56 children with recurrent malignant
astrocytoma
who received conventional chemotherapy following initial progression, no patient survives.
MedlinePlus Health Information.
consumer health - Bone Marrow Transplantation
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
Carmustine
.
Hazardous Substances Data Bank.
ETOPOSIDE
.
Hazardous Substances Data Bank.
CARBOPLATIN
.
Hazardous Substances Data Bank.
THIO-TEPA
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Anticancer Res. 1999 Jul-Aug;19(4C):3569-74
[
10629654.001
]
[Cites]
J Neurooncol. 2006 Mar;77(1):89-94
[
16292488.001
]
[Cites]
Clin Cancer Res. 2001 Jan;7(1):32-7
[
11205914.001
]
[Cites]
Acta Neurochir (Wien). 2002 Dec;144(12):1265-70; discussion 1270
[
12478337.001
]
[Cites]
Cancer Chemother Rep. 1966 Mar;50(3):163-70
[
5910392.001
]
[Cites]
J Neurosurg. 1981 Apr;54(4):455-60
[
6259300.001
]
[Cites]
J Clin Oncol. 1984 May;2(5):432-7
[
6726296.001
]
[Cites]
J Clin Oncol. 1986 May;4(5):639-45
[
3009725.001
]
[Cites]
J Clin Oncol. 1987 May;5(5):783-9
[
3553437.001
]
[Cites]
J Clin Oncol. 1987 Aug;5(8):1221-31
[
3040919.001
]
[Cites]
Br J Cancer. 1988 Dec;58(6):779-82
[
2852028.001
]
[Cites]
J Neurooncol. 1989 May;7(1):5-11
[
2754456.001
]
[Cites]
J Neurooncol. 1989 Jul;7(2):165-77
[
2550594.001
]
[Cites]
J Clin Oncol. 1989 Nov;7(11):1748-56
[
2681557.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1990 Feb;18(2):321-4
[
2154418.001
]
[Cites]
Cancer. 1990 Dec 15;66(12):2465-9
[
2249186.001
]
[Cites]
J Neurooncol. 1990 Dec;9(3):239-48
[
1964962.001
]
[Cites]
J Neurooncol. 1991 Apr;10(2):139-44
[
1654401.001
]
[Cites]
Med Pediatr Oncol. 1993;21(1):49-53
[
8381203.001
]
[Cites]
Cancer. 1993 Jul 1;72(1):271-5
[
8508417.001
]
[Cites]
J Clin Oncol. 1995 Jan;13(1):112-23
[
7799011.001
]
[Cites]
J Neurooncol. 1994;19(1):69-74
[
7815106.001
]
[Cites]
Bone Marrow Transplant. 1996 Mar;17(3):389-94
[
8704692.001
]
[Cites]
J Clin Oncol. 1996 Sep;14(9):2495-503
[
8823328.001
]
[Cites]
Cancer. 1998 Aug 15;83(4):813-6
[
9708950.001
]
[Cites]
J Neurooncol. 1999 May;43(1):43-7
[
10448870.001
]
[Cites]
Bone Marrow Transplant. 2000 Jul;26(2):153-60
[
10918425.001
]
(PMID = 18802947.001).
[ISSN]
1545-5017
[Journal-full-title]
Pediatric blood & cancer
[ISO-abbreviation]
Pediatr Blood Cancer
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / U10 CA013539; United States / NCI NIH HHS / CA / U10 CA098543-06; United States / NCI NIH HHS / CA / CA013539-30; United States / NCI NIH HHS / CA / U10 CA013539-30; United States / NCI NIH HHS / CA / P30 CA021765; United States / NCI NIH HHS / CA / U10 CA098543; United States / NCI NIH HHS / CA / CA021765-259003; United States / NCI NIH HHS / CA / P30 CA021765-259003; None / None / / U10 CA098543-06; United States / NCI NIH HHS / CA / CA 21765
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Myeloablative Agonists; 6PLQ3CP4P3 / Etoposide; 905Z5W3GKH / Thiotepa; BG3F62OND5 / Carboplatin; U68WG3173Y / Carmustine
[Other-IDs]
NLM/ NIHMS65899; NLM/ PMC2844080
[Investigator]
Bleyer A; Khayat A; Sather H; Krailo M; Buckley J; Stram D; Sposto R; Hutchinson R; Matthay K; Gaynon P; Geyer JR; Shurin S; Reaman G; Ortega J; Ruymann F; Weiner M; Blatt J; Lukens J; Wolff L; Neglia J; Lange B; Steinherz P; Breitfeld P; O'Brien R; Cohen H; Fryer C; Wells R; Finklestein J; Feig S; Tannous R; Odom L; Gilchrist G; Barnard D; Wiley J; Ettinger L; Hetherington M; Coccia P; Norris D; Nachman J; Raney B; Baker D; Sanders J; Rausen A; Cairo M
35.
Buckner JC, O'Fallon JR, Dinapoli RP, Schomberg PJ, Farr G, Schaefer P, Giannini C, Scheithauer BW, Ballman KV:
Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade.
J Neurooncol
; 2007 Sep;84(3):279-86
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Prognosis in patients with
anaplastic
oligoastrocytoma is associated with histologic
grade
.
BACKGROUND:
Anaplastic
oligoastrocytomas (AOA) are relatively uncommon high-
grade
gliomas.
METHODS: Between 1980 and 1999, Mayo Clinic and the NCCTG conducted 10 trials of radiation therapy and chemotherapy in adults with newly-diagnosed high-
grade
gliomas.
We grouped patients by cell type and
grade
, compared survival distributions by the log-rank statistic, and performed multiple variable analyses.
RESULTS: Of 1368 patients, 68 (5%) had AOA, including 21
Grade
3 (OA3) and 47
grade
4 (OA4), 153 (11%) had
anaplastic astrocytoma
(AA), and 1147 (84%) had glioblastoma multiforme (GBM).
CONCLUSIONS: Patients with
anaplastic
oligoastrocytoma have distinct outcomes based upon
grade
(OA3 vs. OA4) and in comparison with pure
astrocytoma
(AA or GBM).
Future trials which include more than one histologic entity need to report results by cell type and
grade
and account for the varying prognoses in interpreting treatment outcomes.
[MeSH-major]
Astrocytoma
/ mortality.
Astrocytoma
/ pathology.
Brain
Neoplasms / mortality.
Brain
Neoplasms / pathology
Genetic Alliance.
consumer health - Anaplastic Oligoastrocytoma
.
Genetic Alliance.
consumer health - Oligoastrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Clin Oncol. 2000 Feb;18(3):636-45
[
10653879.001
]
[Cites]
N Engl J Med. 1980 Dec 4;303(23):1323-9
[
7001230.001
]
[Cites]
Stat Med. 1992 Dec;11(16):2093-109
[
1293671.001
]
[Cites]
J Natl Cancer Inst. 1993 May 5;85(9):704-10
[
8478956.001
]
[Cites]
Cancer Treat Rep. 1983 Feb;67(2):121-32
[
6337710.001
]
[Cites]
J Neuropathol Exp Neurol. 1997 Oct;56(10):1098-104
[
9329453.001
]
[Cites]
Am J Pathol. 1994 Nov;145(5):1175-90
[
7977648.001
]
[Cites]
Neurosurgery. 1993 Mar;32(3):365-70; discussion 371
[
8455760.001
]
[Cites]
J Neuropathol Exp Neurol. 2001 Mar;60(3):248-62
[
11245209.001
]
[Cites]
Biometrics. 1992 Jun;48(2):411-25
[
1637970.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1997 Jul 15;38(5):911-4
[
9276354.001
]
[Cites]
Int J Cancer. 1995 Jun 22;64(3):207-10
[
7622310.001
]
[Cites]
Neurosurgery. 1994 Apr;34(4):577-82; discussion 582
[
8008153.001
]
[Cites]
J Neurosurg. 1978 Sep;49(3):333-43
[
355604.001
]
[Cites]
J Neurosurg. 1992 May;76(5):741-5
[
1564535.001
]
[Cites]
J Clin Oncol. 2006 Dec 1;24(34):5419-26
[
17135643.001
]
[Cites]
Int J Cancer. 1994 Apr 15;57(2):172-5
[
8157354.001
]
[Cites]
Cancer Chemother Rep. 1966 Mar;50(3):163-70
[
5910392.001
]
(PMID = 17431544.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
36.
Wick W, Weller M:
[Anaplastic glioma. Neuropathology, molecular diagnostics and current study concepts].
Nervenarzt
; 2010 Aug;81(8):928-30, 932-5
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
[
Anaplastic
glioma. Neuropathology, molecular diagnostics and current study concepts].
According to the current WHO classification
anaplastic
gliomas comprise pure astrocytomas and oligodendrogliomas and mixed tumors.
This review summarizes findings, discusses problems and defines new questions from the phase
III
trials on
anaplastic
gliomas.
Therefore, marker profiles should be included into the next WHO
brain
tumor classification.
The current standard of care for first-line treatment in
anaplastic
gliomas is radiotherapy or chemotherapy.
Inclusion in this trial is already based on the WHO
grade
and the 1p/19q status and not on the histopathological subtype.
Furthermore,
anaplastic
gliomas are an important group
of brain
tumors for developing future molecular targeted therapies and should therefore be in the main focus of academic and industrial drug development, which aims at improved efficacy and avoiding long-term side-effects.
[MeSH-major]
Astrocytoma
/ pathology.
Brain
Neoplasms / pathology. Oligodendroglioma / pathology
[MeSH-minor]
Antineoplastic Agents, Alkylating / therapeutic use.
Brain
/ pathology. Chromosome Deletion. Clinical Trials as Topic. Clinical Trials, Phase
III
as Topic. Combined Modality Therapy. Cranial Irradiation. DNA Modification Methylases / genetics. DNA Mutational Analysis. DNA Repair Enzymes / genetics. Disease-Free Survival. Humans. Isocitrate Dehydrogenase / genetics. Promoter Regions, Genetic / genetics. Survival Rate. Tumor Suppressor Proteins / genetics
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Lancet Oncol. 2009 May;10 (5):459-66
[
19269895.001
]
[Cites]
J Neurol. 2009 May;256(5):734-41
[
19240962.001
]
[Cites]
Science. 2009 Apr 10;324(5924):261-5
[
19359588.001
]
[Cites]
Cancer Res. 2009 May 15;69(10 ):4502-9
[
19366800.001
]
[Cites]
Eur J Cancer. 2008 Jun;44(9):1210-6
[
18248979.001
]
[Cites]
J Neurooncol. 2009 May;92(3):401-15
[
19357966.001
]
[Cites]
J Clin Oncol. 2010 Apr 20;28(12 ):2051-7
[
20308655.001
]
[Cites]
Nat Rev Neurol. 2010 Jan;6(1):39-51
[
19997073.001
]
[Cites]
Science. 2008 Sep 26;321(5897):1807-12
[
18772396.001
]
[Cites]
N Engl J Med. 2000 Nov 9;343(19):1350-4
[
11070098.001
]
[Cites]
Lancet Oncol. 2006 May;7(5):392-401
[
16648043.001
]
[Cites]
J Clin Oncol. 1990 Jul;8(7):1277-80
[
2358840.001
]
[Cites]
J Clin Oncol. 2003 Sep 1;21(17):3276-84
[
12947063.001
]
[Cites]
Neuro Oncol. 2008 Dec;10 (6):1019-24
[
18676355.001
]
[Cites]
J Clin Oncol. 2009 Dec 10;27(35):5881-6
[
19901104.001
]
[Cites]
J Clin Oncol. 2010 Apr 10;28(11):1963-72
[
20231676.001
]
[Cites]
J Natl Cancer Inst. 1998 Oct 7;90(19):1473-9
[
9776413.001
]
[Cites]
J Neuropathol Exp Neurol. 2006 Oct;65(10):988-94
[
17021403.001
]
[Cites]
Acta Neuropathol. 2007 Aug;114(2):97-109
[
17618441.001
]
[Cites]
Neuro Oncol. 2009 Dec;11(6):737-46
[
19224764.001
]
[Cites]
Cancer Res. 2006 Oct 15;66(20):9852-61
[
17047046.001
]
[Cites]
J Clin Oncol. 2009 Oct 1;27(28):4733-40
[
19720927.001
]
[Cites]
Cancer Cell. 2010 May 18;17(5):510-22
[
20399149.001
]
[Cites]
Clin Cancer Res. 2008 Nov 1;14 (21):7068-73
[
18981004.001
]
[Cites]
J Clin Oncol. 2007 Aug 1;25(22):3357-61
[
17664483.001
]
[Cites]
J Clin Oncol. 2006 Jun 20;24(18):2707-14
[
16782910.001
]
[Cites]
Brain Pathol. 2002 Apr;12(2):257-9
[
11958379.001
]
[Cites]
N Engl J Med. 2009 Feb 19;360(8):765-73
[
19228619.001
]
[Cites]
J Clin Oncol. 2009 Dec 10;27(35):5874-80
[
19901110.001
]
[Cites]
Acta Neuropathol. 2009 Oct;118(4):469-74
[
19554337.001
]
[Cites]
J Clin Oncol. 2006 Mar 10;24(8):1281-8
[
16525183.001
]
[Cites]
J Clin Oncol. 2006 Jun 20;24(18):2715-22
[
16782911.001
]
[Cites]
J Neurosurg. 2008 Feb;108(2):330-5
[
18240930.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10 ):997-1003
[
15758010.001
]
[Cites]
Clin Cancer Res. 2007 Dec 1;13(23):6933-7
[
18056167.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10 ):987-96
[
15758009.001
]
[Cites]
Neurology. 2006 Jan 24;66(2):239-42
[
16434662.001
]
(PMID = 20635074.001).
[ISSN]
1433-0407
[Journal-full-title]
Der Nervenarzt
[ISO-abbreviation]
Nervenarzt
[Language]
ger
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 0 / Tumor Suppressor Proteins; EC 1.1.1.41 / Isocitrate Dehydrogenase; EC 1.1.1.42. / IDH1 protein, human; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 6.5.1.- / DNA Repair Enzymes
37.
Parbel S, Vlaho S, Gebhardt B, Porto L, Hattingen E, Klingebiel T, Böhles H, Kieslich M:
[Diagnostic difficulties in encephalitis and glioma].
Klin Padiatr
; 2007 Jul-Aug;219(4):222-4
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
The differential
diagnosis
between cerebral glioma and infective lesions can be very difficult to distinguish by MRI only.
Brain
biopsy revealed
anaplastic astrocytoma
(WHO
III
).
CONCLUSION: This case report shows that cerebral glioma can mimick infective
brain
disease and that MR-spectroscopy is an important non-invasive tool in this differential
diagnosis
.
[MeSH-major]
Astrocytoma
/
diagnosis
.
Brain
Stem Neoplasms /
diagnosis
. Cerebellar Neoplasms /
diagnosis
. Encephalitis /
diagnosis
. Magnetic Resonance Spectroscopy. Pons
[MeSH-minor]
Aspartic Acid / analogs & derivatives. Aspartic Acid / analysis. Child. Choline / analysis. Creatine / analysis.
Diagnosis
, Differential. Humans. Magnetic Resonance Imaging. Male
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Encephalitis
.
Hazardous Substances Data Bank.
(L)-ASPARTIC ACID
.
Hazardous Substances Data Bank.
CREATINE
.
Hazardous Substances Data Bank.
CHOLINE CHLORIDE
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16865652.001).
[ISSN]
0300-8630
[Journal-full-title]
Klinische Pädiatrie
[ISO-abbreviation]
Klin Padiatr
[Language]
ger
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
30KYC7MIAI / Aspartic Acid; 997-55-7 / N-acetylaspartate; MU72812GK0 / Creatine; N91BDP6H0X / Choline
38.
Watanabe T, Katayama Y, Ogino A, Ohta T, Yoshino A, Fukushima T:
Preliminary individualized chemotherapy for malignant astrocytomas based on O6-methylguanine-deoxyribonucleic acid methyltransferase methylation analysis.
Neurol Med Chir (Tokyo)
; 2006 Aug;46(8):387-93; discussion 393-4
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
This study was a preliminary trial of individualized chemotherapy based on MGMT methylation status in a total of 20 patients with newly diagnosed malignant astrocytomas (9
anaplastic
astrocytomas and 11 glioblastomas multiforme).
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Astrocytoma
/ drug therapy.
Astrocytoma
/ genetics.
Brain
Neoplasms / drug therapy.
Brain
Neoplasms / genetics. DNA Methylation. O(6)-Methylguanine-DNA Methyltransferase / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16936459.001).
[ISSN]
0470-8105
[Journal-full-title]
Neurologia medico-chirurgica
[ISO-abbreviation]
Neurol. Med. Chir. (Tokyo)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Alkylating Agents; 0 / Nitrosourea Compounds; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
39.
Callovini GM:
Is it appropriate to redefine the indication for stereotactic brain biopsy in the MRI Era? Correlation with final histological diagnosis in supratentorial gliomas.
Minim Invasive Neurosurg
; 2008 Apr;51(2):109-13
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Is it appropriate to redefine the indication for stereotactic
brain
biopsy in the MRI Era? Correlation with final histological
diagnosis
in supratentorial gliomas.
BACKGROUND: The aim of this study was to evaluate the advisability of modifying the indications for stereotactic
brain
biopsy (SBB) in high- and low-
grade
supratentorial glial tumors in correlation with the diagnostic accuracy of magnetic resonance imaging (MRI).
On the basis of the MRI findings the patients were divided into two groups: high-
grade
(n=107) and low-
grade
(n=67) gliomas.
Only one preoperative
diagnosis
was allowed.
RESULTS: A final histological
diagnosis
was achieved in 95% of the 174 cases.
In the group of high-
grade
gliomas (HGG) there was diagnostic coincidence in 87% of cases, reaching 100% in lesions of the corpus callosum.
In 11 cases (10%) the histological analysis changed the presumptive
diagnosis
and the consequent management.
In the group of low-
grade
gliomas (LGG) there was diagnostic coincidence in 63% (42 cases), whereas there was discordance in 30%: 10 cases were upgraded to
anaplastic astrocytoma
, and in 10 cases no tumors were observed at all.
CONCLUSIONS: In the future, the histological
diagnosis
of glial tumors will include molecular genetic definition, thus making it crucial for management using the new therapeutic options.
Today, the indications for biopsy in lesions mimicking high-
grade
gliomas are mainly linked to the site of the tumor, coexisting differential diagnoses or more than one treatment option.
On the contrary, in lesions where MRI findings indicate low-
grade
gliomas, grading is crucial also in order to avoid treatment inappropriate in non-neoplastic lesions.
[MeSH-major]
Astrocytoma
/ pathology.
Brain
/ pathology. Glioma / pathology. Magnetic Resonance Imaging / standards. Neoplasm Recurrence, Local / pathology. Stereotaxic Techniques / standards. Supratentorial Neoplasms / pathology
[MeSH-minor]
Adolescent. Adult. Aged. Child. Corpus Callosum / pathology. Corpus Callosum / radiography.
Diagnosis
, Differential. Diagnostic Errors / prevention & control. Female. Humans. Male. Middle Aged. Necrosis. Observer Variation. Predictive Value of Tests. Radiation Injuries / pathology. Radiation Injuries / radiography. Retrospective Studies. Tomography, X-Ray Computed
MedlinePlus Health Information.
consumer health - MRI Scans
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18401825.001).
[ISSN]
0946-7211
[Journal-full-title]
Minimally invasive neurosurgery : MIN
[ISO-abbreviation]
Minim Invasive Neurosurg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
40.
Rao SA, Santosh V, Somasundaram K:
Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma.
Mod Pathol
; 2010 Oct;23(10):1404-17
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Genome-wide expression profiling identifies deregulated miRNAs in malignant
astrocytoma
.
Malignant
astrocytoma
includes
anaplastic astrocytoma
(
grade III
) and glioblastoma (
grade
IV).
Among them, glioblastoma is the most common primary
brain
tumor with dismal responses to all therapeutic modalities.
We performed a large-scale, genome-wide microRNA (miRNA) (n=756) expression profiling of 26 glioblastoma, 13
anaplastic astrocytoma
and 7 normal
brain
samples with an aim to find deregulated miRNA in malignant
astrocytoma
.
We identified several differentially regulated miRNAs between these groups, which could differentiate glioma grades and normal
brain
as recognized by PCA.
More importantly, we identified a most discriminatory 23-miRNA expression signature, by using PAM, which precisely distinguished glioblastoma from
anaplastic astrocytoma
with an accuracy of 95%.
Thus we have identified the miRNA expression signature for malignant
astrocytoma
, in particular glioblastoma, and showed the miRNA involvement and their importance in
astrocytoma
development.
[MeSH-major]
Astrocytoma
/ genetics. Biomarkers, Tumor / genetics.
Brain
Neoplasms / genetics. MicroRNAs / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 20711171.001).
[ISSN]
1530-0285
[Journal-full-title]
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
[ISO-abbreviation]
Mod. Pathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / MicroRNAs
41.
Takaya S, Hashikawa K, Turkheimer FE, Mottram N, Deprez M, Ishizu K, Kawashima H, Akiyama H, Fukuyama H, Banati RB, Roncaroli F:
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
J Neurooncol
; 2007 Oct;85(1):95-103
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
The lack of expression of the peripheral benzodiazepine receptor characterises microglial response in
anaplastic
astrocytomas.
We examined two
anaplastic
astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood
brain
barrier to minimise the presence of blood borne macrophages within tumour tissue.
The expression profile of four
anaplastic
astrocytomas was also exploited and results were compared to the profile of eleven samples of normal temporal lobe and nine cases of PD.
[MeSH-major]
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology.
Brain
Neoplasms / metabolism.
Brain
Neoplasms / pathology. Microglia / metabolism. Microglia / pathology. Receptors, GABA-A / biosynthesis
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
ORBi (University of Liege).
Free full Text at ORBi
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
BMC Bioinformatics. 2006 Dec 01;7:526
[
17140431.001
]
[Cites]
Glia. 2002 Nov;40(2):206-17
[
12379908.001
]
[Cites]
J Neuropathol Exp Neurol. 2002 Mar;61(3):215-25; discussion 226-9
[
11895036.001
]
[Cites]
Dev Neurosci. 2004 Jan-Feb;26(1):30-7
[
15509896.001
]
[Cites]
Ann Neurol. 1988 Dec;24(6):708-12
[
2849920.001
]
[Cites]
Acta Neuropathol. 1996 Sep;92(3):288-93
[
8870831.001
]
[Cites]
J Neurochem. 2000 Apr;74(4):1694-704
[
10737628.001
]
[Cites]
Neurobiol Dis. 2003 Dec;14 (3):417-24
[
14678758.001
]
[Cites]
J Neurooncol. 1998 May;38(1):19-26
[
9540054.001
]
[Cites]
Lab Invest. 1994 Jan;70(1):23-8
[
8302015.001
]
[Cites]
Neuropathol Appl Neurobiol. 1998 Aug;24(4):293-301
[
9775395.001
]
[Cites]
Trends Pharmacol Sci. 2006 Aug;27(8):402-9
[
16822554.001
]
[Cites]
Acta Neurochir (Wien). 1992;119(1-4):146-52
[
1336303.001
]
[Cites]
Brain. 2004 Jun;127(Pt 6):1379-92
[
15069023.001
]
[Cites]
Cancer Res. 1988 Oct 15;48(20):5837-41
[
3262414.001
]
[Cites]
J Histochem Cytochem. 2004 Jan;52(1):19-28
[
14688214.001
]
[Cites]
Mol Med. 2006 Jul-Aug;12(7-8):161-70
[
17088948.001
]
[Cites]
Acta Neuropathol. 2004 Jul;108(1):43-8
[
15088099.001
]
[Cites]
J Neurosci Res. 2005 Aug 1;81(3):447-55
[
15959903.001
]
[Cites]
J Nucl Med. 2007 Jan;48(1):158-67
[
17204713.001
]
[Cites]
Science. 2005 May 27;308(5726):1314-8
[
15831717.001
]
[Cites]
Neurogenetics. 2004 Jun;5(2):95-108
[
15042428.001
]
[Cites]
J Neurosci Res. 2005 Aug 1;81(3):327-41
[
15948185.001
]
[Cites]
J Neurosci Res. 2006 May 15;83(7):1293-8
[
16547968.001
]
[Cites]
Brain Res. 1990 Jun 4;518(1-2):199-208
[
2167748.001
]
[Cites]
Ann Neurol. 1989 Dec;26(6):752-8
[
2557794.001
]
[Cites]
Cancer Lett. 2000 Aug 11;156(2):125-32
[
10880761.001
]
[Cites]
J Nucl Med. 1991 Aug;32(8):1608-10
[
1651383.001
]
[Cites]
J Neurooncol. 2007 Jan;81(1):1-7
[
16868661.001
]
[Cites]
Trends Neurosci. 2006 Feb;29(2):68-74
[
16406093.001
]
[Cites]
Pharmacol Ther. 2006 Jun;110(3):503-24
[
16337685.001
]
[Cites]
Cancer Res. 2001 Jun 1;61(11):4375-81
[
11389063.001
]
[Cites]
J Neurochem. 2002 Nov;83(3):546-55
[
12390516.001
]
[Cites]
Eur J Pharmacol. 1992 Sep 1;228(2-3):131-9
[
1332878.001
]
[Cites]
J Recept Signal Transduct Res. 2003;23(2-3):225-38
[
14626449.001
]
[Cites]
J Neuroinflammation. 2005 Oct 31;2:24
[
16259628.001
]
[Cites]
J Neurocytol. 1997 Feb;26(2):77-82
[
9181482.001
]
[Cites]
Trends Neurosci. 1996 Aug;19(8):312-8
[
8843599.001
]
[Cites]
Pharmacol Rev. 1999 Dec;51(4):629-50
[
10581326.001
]
[Cites]
Cytometry. 1996 May 1;24(1):39-48
[
8723901.001
]
[Cites]
Cancer Res. 1995 Jun 15;55(12):2691-5
[
7780986.001
]
[Cites]
Neuro Oncol. 2006 Jul;8(3):261-79
[
16775224.001
]
[Cites]
IEEE Trans Med Imaging. 2003 Mar;22(3):289-301
[
12760547.001
]
[Cites]
Life Sci. 2004 Jan 30;74(11):1387-95
[
14706569.001
]
[Cites]
Ann Neurol. 1989 Oct;26(4):564-8
[
2554790.001
]
[Cites]
Glia. 2005 Sep;51(4):279-85
[
15818597.001
]
[Cites]
J Cereb Blood Flow Metab. 1996 Sep;16(5):834-40
[
8784228.001
]
[Cites]
Brain. 2000 Nov;123 ( Pt 11):2321-37
[
11050032.001
]
[Cites]
Cancer. 1990 Jan 1;65(1):93-7
[
2152852.001
]
(PMID = 17520179.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Grant]
United Kingdom / Medical Research Council / / MC/ U120085814
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Isoquinolines; 0 / RNA, Messenger; 0 / Radiopharmaceuticals; 0 / Receptors, GABA-A; YNF83VN1RL / PK 11195
42.
Weller M, Berger H, Hartmann C, Schramm J, Westphal M, Simon M, Goldbrunner R, Krex D, Steinbach JP, Ostertag CB, Loeffler M, Pietsch T, von Deimling A, German Glioma Network:
Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?
Clin Cancer Res
; 2007 Dec 1;13(23):6933-7
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
PURPOSE: The combined loss of genetic material on chromosomes 1p and 19q is strongly associated with favorable outcome in patients with WHO
grade
3
anaplastic
oligodendroglial tumors.
The prognostic value of 1p/19q loss in WHO
grade
2 oligodendroglial tumors is less well defined.
EXPERIMENTAL DESIGN: Seventy-six patients with oligodendroglioma (n = 33), oligoastrocytoma (n = 30),
anaplastic
oligodendroglioma (n = 6), or
anaplastic
oligoastrocytoma (n = 7) were identified who had not received radiotherapy or chemotherapy after their first operation until the end of follow-up or until the first progression and had tissue for 1p/19q status available.
[MeSH-major]
Brain
Neoplasms / genetics. Chromosome Deletion. Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 19. Oligodendroglioma / genetics
[MeSH-minor]
Adolescent. Adult. Aged.
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Biomarkers, Tumor / genetics. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18056167.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
43.
Ashamalla H, Zaki B, Mokhtar B, Lewis L, Lavaf A, Nasr H, Colella F, Dosik D, Krishnamurthy M, Saad N, Guriguis A:
Fractionated stereotactic radiotherapy boost and weekly paclitaxel in malignant gliomas clinical and pharmacokinetics results.
Technol Cancer Res Treat
; 2007 Jun;6(3):169-76
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Twenty-three Glioblastoma Multiforme and two
Anaplastic Astrocytoma
were studied.
The median survival for RPA prognostic classes
III
, IV, V, and VI were 20, 14, 12, and 11 months.
No
grade
4 CTCAE (version 3.0) toxicities were observed.
ii) the regimen resulted in improvement of survival of RPA classes IV, V, VI; and
iii
) the use of FSRT boost may be studied with other chemotherapeutic agents to see if superior results can be attained.
[MeSH-major]
Antineoplastic Agents, Phytogenic / pharmacokinetics.
Brain
Neoplasms / therapy. Glioma / therapy. Paclitaxel / pharmacokinetics. Radiosurgery / methods
MedlinePlus Health Information.
consumer health - Brain Tumors
.
Hazardous Substances Data Bank.
TAXOL
.
Hazardous Substances Data Bank.
PHENYTOIN
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17535024.001).
[ISSN]
1533-0346
[Journal-full-title]
Technology in cancer research & treatment
[ISO-abbreviation]
Technol. Cancer Res. Treat.
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Anticonvulsants; 0 / Antineoplastic Agents, Phytogenic; 6158TKW0C5 / Phenytoin; P88XT4IS4D / Paclitaxel
44.
Chan DT, Poon WS, Chan YL, Ng HK:
Temozolomide in the treatment of recurrent malignant glioma in Chinese patients.
Hong Kong Med J
; 2005 Dec;11(6):452-6
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Histology reviewed by a neuropathologist was required to show
anaplastic
glioma (
anaplastic astrocytoma
,
anaplastic
oligodendroglioma, or mixed
anaplastic
oligoastrocytoma) or glioblastoma multiforme.
Genetic Alliance.
consumer health - Glioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
Hazardous Substances Data Bank.
DACARBAZINE
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16340021.001).
[ISSN]
1024-2708
[Journal-full-title]
Hong Kong medical journal = Xianggang yi xue za zhi
[ISO-abbreviation]
Hong Kong Med J
[Language]
ENG
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
China
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
45.
Chamberlain MC, Johnston S:
Bevacizumab for recurrent alkylator-refractory anaplastic oligodendroglioma.
Cancer
; 2009 Apr 15;115(8):1734-43
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Bevacizumab for recurrent alkylator-refractory
anaplastic
oligodendroglioma.
BACKGROUND: A retrospective evaluation of single agent bevacizumab was carried out in adults with recurrent alkylator-refractory 1p19q codeleted
anaplastic
oligodendrogliomas (AO) with an objective of determining progression-free survival (PFS).
Bevacizumab-related toxicity included fatigue (14 patients; 4
grade
3), leukopenia (9; 1
grade
3), anemia (5; 0
grade
3), hypertension (5; 1
grade
3), deep vein thrombosis (4; 1
grade
3), and wound dehiscence (2; 1
grade
3).
[MeSH-major]
Angiogenesis Inhibitors / therapeutic use. Antibodies, Monoclonal / therapeutic use.
Brain
Neoplasms / drug therapy. Oligodendroglioma / drug therapy
[MeSH-minor]
Adult. Antibodies, Monoclonal, Humanized. Antineoplastic Agents, Alkylating / therapeutic use.
Astrocytoma
/ drug therapy. Bevacizumab. Chromosomes, Human, Pair 1. Disease-Free Survival. Drug Resistance, Neoplasm. Female. Humans. Male. Middle Aged. Retrospective Studies. Survival Analysis
Genetic Alliance.
consumer health - Anaplastic Oligodendroglioma
.
Genetic Alliance.
consumer health - Oligodendroglioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19197992.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents, Alkylating; 2S9ZZM9Q9V / Bevacizumab
46.
Gutin PH, Iwamoto FM, Beal K, Mohile NA, Karimi S, Hou BL, Lymberis S, Yamada Y, Chang J, Abrey LE:
Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas.
Int J Radiat Oncol Biol Phys
; 2009 Sep 1;75(1):156-63
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Bevacizumab, a monoclonal antibody against VEGF, has shown promise in recurrent gliomas, but the safety and efficacy of concurrent bevacizumab with
brain
irradiation has not been extensively studied.
METHODS AND MATERIALS: After prior treatment with standard radiation therapy patients with recurrent glioblastoma (GBM) and
anaplastic
gliomas (AG) received bevacizumab (10 mg/kg intravenous) every 2 weeks of 28-day cycles until tumor progression.
Three patients discontinued treatment because of
Grade
3 central nervous system intratumoral hemorrhage, wound dehiscence, and bowel perforation.
[MeSH-major]
Angiogenesis Inhibitors / therapeutic use. Antibodies, Monoclonal / therapeutic use.
Astrocytoma
.
Brain
Neoplasms. Neoplasm Recurrence, Local. Radiosurgery
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Am J Clin Oncol. 2004 Dec;27(6):646-8
[
15577450.001
]
[Cites]
BMC Cancer. 2005;5:55
[
15924621.001
]
[Cites]
J Clin Oncol. 2005 Nov 1;23(31):8136-9
[
16258121.001
]
[Cites]
Neurosignals. 2005;14(5):207-21
[
16301836.001
]
[Cites]
Lung Cancer. 2006 Jan;51(1):97-103
[
16213059.001
]
[Cites]
J Clin Oncol. 2006 Feb 10;24(5):769-77
[
16391297.001
]
[Cites]
Nat Rev Cancer. 2006 Aug;6(8):626-35
[
16837971.001
]
[Cites]
Cancer Res. 2006 Aug 15;66(16):7843-8
[
16912155.001
]
[Cites]
Acta Oncol. 2006;45(7):848-55
[
16982549.001
]
[Cites]
N Engl J Med. 2006 Dec 14;355(24):2542-50
[
17167137.001
]
[Cites]
J Clin Oncol. 1999 Aug;17(8):2572-8
[
10561324.001
]
[Cites]
Cancer Treat Rev. 2000 Dec;26(6):397-409
[
11139371.001
]
[Cites]
Cancer Res. 2001 Jan 1;61(1):39-44
[
11196192.001
]
[Cites]
J Magn Reson Imaging. 2002 Mar;15(3):233-40
[
11891967.001
]
[Cites]
Nat Rev Cancer. 2002 Nov;2(11):826-35
[
12415253.001
]
[Cites]
Clin Cancer Res. 2003 Apr;9(4):1399-405
[
12684411.001
]
[Cites]
Science. 2003 May 16;300(5622):1155-9
[
12750523.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1017-21
[
15001240.001
]
[Cites]
Cancer Cell. 2004 May;5(5):429-41
[
15144951.001
]
[Cites]
N Engl J Med. 2004 Jun 3;350(23):2335-42
[
15175435.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1979 Oct;5(10):1725-31
[
231022.001
]
[Cites]
Neurology. 1980 Sep;30(9):907-11
[
6252514.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1980 Sep;6(9):1215-28
[
7007303.001
]
[Cites]
Science. 1983 Feb 25;219(4587):983-5
[
6823562.001
]
[Cites]
Cancer Res. 1986 Feb;46(2):723-7
[
3940638.001
]
[Cites]
Cancer Cell. 2007 Jan;11(1):69-82
[
17222791.001
]
[Cites]
Cancer Cell. 2007 Jan;11(1):83-95
[
17222792.001
]
[Cites]
Clin Cancer Res. 2007 Feb 15;13(4):1253-9
[
17317837.001
]
[Cites]
Radiother Oncol. 2007 Feb;82(2):185-90
[
17257702.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2007 Jun 1;68(2):472-8
[
17498568.001
]
[Cites]
Cancer Res. 2007 Jun 1;67(11):5076-82
[
17545583.001
]
[Cites]
Trends Mol Med. 2007 Jun;13(6):223-30
[
17462954.001
]
[Cites]
Nat Rev Neurosci. 2007 Aug;8(8):610-22
[
17643088.001
]
[Cites]
J Clin Oncol. 2007 Oct 20;25(30):4722-9
[
17947719.001
]
[Cites]
J Clin Oncol. 2008 Jan 10;26(2):271-8
[
18182667.001
]
[Cites]
Cancer Cell. 2008 Mar;13(3):193-205
[
18328424.001
]
[Cites]
N Engl J Med. 2008 May 8;358(19):2039-49
[
18463380.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):484-90
[
18234445.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):324-5
[
18474308.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2008 Aug 1;71(5):1372-80
[
18355978.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2007 Mar 1;67(3):870-8
[
17293237.001
]
[Cites]
J Clin Oncol. 1990 Jul;8(7):1277-80
[
2358840.001
]
[Cites]
Magn Reson Med. 1992 Mar;24(1):174-6
[
1556924.001
]
[Cites]
Nature. 1992 Oct 29;359(6398):845-8
[
1279432.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1997 Jan 15;37(2):375-83
[
9069310.001
]
[Cites]
Cancer Res. 1999 Jul 15;59(14):3374-8
[
10416597.001
]
(PMID = 19167838.001).
[ISSN]
1879-355X
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Databank-accession-numbers]
ClinicalTrials.gov/ NCT00595322
[Grant]
United States / NCI NIH HHS / CA / P30 CA008748
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab
[Other-IDs]
NLM/ NIHMS460357; NLM/ PMC3659401
47.
Silvani A, Gaviani P, Fiumani A, Scaioli V, Lamperti E, Eoli M, Botturi A, Salmaggi A:
Systemic sagopilone (ZK-EPO) treatment of patients with recurrent malignant gliomas.
J Neurooncol
; 2009 Oct;95(1):61-64
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
PFS-6 was achieved in five patients (33%), three with glioblastoma multiforme and two with
anaplastic astrocytoma
.
[MeSH-major]
Antineoplastic Agents / therapeutic use. Benzothiazoles / therapeutic use.
Brain
Neoplasms / drug therapy. Epothilones / therapeutic use. Glioma / drug therapy
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Cancer Chemotherapy
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Neuro Oncol. 2009 Apr;11(2):158-66
[
18780814.001
]
[Cites]
Neurology. 2006 Feb 28;66(4):587-9
[
16505319.001
]
[Cites]
Cancer J. 2008 Sep-Oct;14 (5):279-85
[
18836331.001
]
[Cites]
J Clin Oncol. 1990 Jul;8(7):1277-80
[
2358840.001
]
[Cites]
J Clin Oncol. 1999 Jul;17(7):2069-80
[
10561260.001
]
[Cites]
Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7942-8
[
17006870.001
]
[Cites]
Expert Opin Investig Drugs. 2008 Nov;17(11):1735-48
[
18922109.001
]
[Cites]
Oncologist. 2006 Feb;11(2):165-80
[
16476837.001
]
[Cites]
Clin Neurol Neurosurg. 1997 May;99(2):117-23
[
9213056.001
]
[Cites]
Cancer Res. 2008 Jul 1;68(13):5301-8
[
18593931.001
]
[Cites]
J Neurooncol. 2003 Nov;65(2):99-106
[
14686728.001
]
[Cites]
Drugs. 2008;68(2):139-46
[
18197722.001
]
[Cites]
Anticancer Drugs. 2008 Jul;19(6):613-20
[
18525321.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10 ):987-96
[
15758009.001
]
(PMID = 19381446.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Benzothiazoles; 0 / Epothilones; 0 / sagopilone
48.
Perry J, Chambers A, Spithoff K, Laperriere N:
Gliadel wafers in the treatment of malignant glioma: a systematic review.
Curr Oncol
; 2007 Oct;14(5):189-94
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
QUESTION: What is the safety and efficacy of interstitial chemotherapy with carmustine-loaded polymers (Gliadel wafers: MGI Pharma, Bloomington, MN, U.S.A.) in the treatment of newly diagnosed or recurrent malignant glioma (that is, glioblastoma multiforme,
anaplastic astrocytoma
,
anaplastic
oligoastrocytoma, and
anaplastic
oligodendroglioma)?
PERSPECTIVES: Malignant glioma is the most common type of primary
brain
tumour in adults.
The most frequently reported adverse events were convulsions, confusion,
brain
edema, infection, hemiparesis, aphasia, and visual field defects.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Neurosurgery. 1999 Jul;45(1):17-22; discussion 22-3
[
10414561.001
]
[Cites]
Surg Neurol. 2000 May;53(5):458-64
[
10874145.001
]
[Cites]
Neuro Oncol. 2003 Apr;5(2):79-88
[
12672279.001
]
[Cites]
J Clin Oncol. 2003 May 1;21(9):1845-9
[
12721262.001
]
[Cites]
Neurosurgery. 1997 Jul;41(1):44-8; discussion 48-9
[
9218294.001
]
[Cites]
J Neurosurg. 1991 Mar;74(3):441-6
[
1993909.001
]
[Cites]
Lancet. 1995 Apr 22;345(8956):1008-12
[
7723496.001
]
[Cites]
J Clin Oncol. 1995 Feb;13(2):502-12
[
7844612.001
]
[Cites]
Acta Neurochir (Wien). 2006 Mar;148(3):269-75; discussion 275
[
16482400.001
]
(PMID = 17938702.001).
[ISSN]
1198-0052
[Journal-full-title]
Current oncology (Toronto, Ont.)
[ISO-abbreviation]
Curr Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Canada
[Other-IDs]
NLM/ PMC2002480
[Keywords]
NOTNLM ; Gliadel / carmustine / glioblastoma / interstitial chemotherapy / malignant glioma / systematic review
49.
Weber MA, Vogt-Schaden M, Bossert O, Giesel FL, Kauczor HU, Essig M:
[MR perfusion and spectroscopic imaging in WHO grade II astrocytomas].
Radiologe
; 2007 Sep;47(9):812-8
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
[MR perfusion and spectroscopic imaging in WHO
grade
II astrocytomas].
BACKGROUND: This study evaluates whether MR perfusion imaging and spectroscopic imaging (MRSI) can depict
anaplastic
areas in WHO
grade
II astrocytomas, whether these areas are co-localized, and whether the prognosis can be better predicted.
MATERIAL AND METHODS: Fifteen patients (nine female, six male, aged 42+/-14 years) with WHO
grade
II astrocytomas but without preceding radio- or chemotherapy were examined every 3 months with MR perfusion imaging and MRSI (mean follow-up 18 months).
CONCLUSIONS: MR perfusion imaging can depict
anaplastic
areas in WHO
grade
II astrocytomas earlier than conventional MRI and thus enables a better prediction of prognosis.
[MeSH-major]
Astrocytoma
/
diagnosis
.
Brain
Neoplasms /
diagnosis
. Magnetic Resonance Imaging. Magnetic Resonance Spectroscopy
[MeSH-minor]
Adult.
Brain
/ pathology. Data Interpretation, Statistical. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Time Factors. World Health Organization
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - MRI Scans
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
AJNR Am J Neuroradiol. 2001 Aug;22(7):1316-24
[
11498420.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2003 Nov 15;57(4):996-1003
[
14575830.001
]
[Cites]
Eur Radiol. 2004 Apr;14(4):679-85
[
14610685.001
]
[Cites]
Australas Radiol. 2001 Nov;45(4):472-82
[
11903181.001
]
[Cites]
AJNR Am J Neuroradiol. 2004 Feb;25(2):214-21
[
14970020.001
]
[Cites]
CA Cancer J Clin. 1999 Jan-Feb;49(1):8-31, 1
[
10200775.001
]
[Cites]
Radiology. 2002 Apr;223(1):11-29
[
11930044.001
]
[Cites]
AJR Am J Roentgenol. 1998 Dec;171(6):1479-86
[
9843274.001
]
[Cites]
Magn Reson Med. 1996 Nov;36(5):715-25
[
8916022.001
]
[Cites]
J Neurosurg. 1993 Oct;79(4):533-6
[
8410222.001
]
[Cites]
Neuroradiology. 2005 Nov;47(11):826-34
[
16142479.001
]
[Cites]
Radiology. 2006 Feb;238(2):658-67
[
16396838.001
]
[Cites]
Neurosci Lett. 2003 May 22;342(3):163-6
[
12757890.001
]
[Cites]
Radiologe. 2000 Oct;40(10):849-57
[
11103407.001
]
[Cites]
Magn Reson Med. 1996 Nov;36(5):726-36
[
8916023.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):478-82
[
11567824.001
]
[Cites]
Invest Radiol. 2004 May;39(5):277-87
[
15087722.001
]
[Cites]
Surg Neurol. 1998 Apr;49(4):436-40
[
9537664.001
]
[Cites]
Radiology. 1994 Apr;191(1):41-51
[
8134596.001
]
[Cites]
Rofo. 1999 Jul;171(1):38-43
[
10464503.001
]
[Cites]
Radiology. 2003 Aug;228(2):523-32
[
12819338.001
]
[Cites]
AJNR Am J Neuroradiol. 2003 Nov-Dec;24(10):1989-98
[
14625221.001
]
[Cites]
Lancet Neurol. 2005 Nov;4(11):760-70
[
16239183.001
]
[Cites]
Nat Med. 1996 Mar;2(3):323-5
[
8612232.001
]
[Cites]
Radiologe. 2002 Nov;42(11):909-15
[
12458444.001
]
[Cites]
Radiologe. 2005 Jul;45(7):618-32
[
15098092.001
]
(PMID = 16924439.001).
[ISSN]
0033-832X
[Journal-full-title]
Der Radiologe
[ISO-abbreviation]
Radiologe
[Language]
ger
[Publication-type]
Comparative Study; English Abstract; Evaluation Studies; Journal Article
[Publication-country]
Germany
50.
Walid MS, Troup EC:
Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease.
J Neurooncol
; 2008 Aug;89(1):59-62
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Cerebellar
anaplastic astrocytoma
in a teenager with Ollier Disease.
INTRODUCTION: Ollier Disease is a sporadic skeletal
disorder
with a predisposition to oncogenesis.
We are presenting a young patient with Ollier Disease and high-
grade
astrocytoma
.
Brain
MRI with contrast showed a 41 x 55 mm mass in the posterior fossa with spotty enhancement, which pathology proved to be
anaplastic astrocytoma
.
[MeSH-major]
Astrocytoma
/ etiology.
Astrocytoma
/ pathology. Cerebellar Neoplasms / etiology. Cerebellar Neoplasms / pathology. Cerebellum / pathology. Enchondromatosis / complications
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
Genetic Alliance.
consumer health - Ollier disease
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Am J Pathol. 2005 Sep;167(3):859-67
[
16127163.001
]
[Cites]
J Laryngol Otol. 2001 Oct;115(10 ):845-7
[
11668006.001
]
[Cites]
Orphanet J Rare Dis. 2006 Sep 22;1:37
[
16995932.001
]
[Cites]
Saudi Med J. 2004 Sep;25(9):1261-3
[
15448780.001
]
[Cites]
AJR Am J Roentgenol. 2001 Feb;176(2):289-96
[
11159059.001
]
[Cites]
Cancer Genet Cytogenet. 2003 May;143(1):1-31
[
12742153.001
]
[Cites]
Childs Nerv Syst. 1999 May;15(5):222-5
[
10392492.001
]
[Cites]
Am J Med Genet A. 2004 Oct 1;130A(2):123-7
[
15372512.001
]
[Cites]
Brain Res. 2000 Jun 23;868(2):230-40
[
10854575.001
]
[Cites]
J Bone Joint Surg Am. 1987 Feb;69(2):269-74
[
3805090.001
]
[Cites]
Clin Neurol Neurosurg. 1999 Jun;101(2):106-10
[
10467905.001
]
(PMID = 18414790.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / PTH1R protein, human; 0 / Receptor, Parathyroid Hormone, Type 1; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.1.3.67 / PTEN protein, human
51.
Larysz D, Blamek S, Larysz P, Pietras K, Mandera M:
Posterior fossa brain tissue injury: developmental, neuropsychological, and neurological consequences of brain tumors in children.
Acta Neurochir Suppl
; 2010;106:271-4
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Posterior fossa
brain
tissue injury: developmental, neuropsychological, and neurological consequences
of brain
tumors in children.
Histopathological diagnoses of tumors were as follows: 4 medulloblastomas, 8 pilocytic astrocytomas, 6 fibrillary astrocytomas, 1
anaplastic astrocytoma
, 2 oligodendrogliomas, 4
anaplastic
ependymomas, 1 choroid plexus papilloma, and 5 arachnoid cysts.
[MeSH-major]
Brain
.
Brain
Injuries / etiology. Cognition Disorders / etiology. Infratentorial Neoplasms. Nervous System Diseases / etiology
MedlinePlus Health Information.
consumer health - Neurologic Diseases
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19812963.001).
[ISSN]
0065-1419
[Journal-full-title]
Acta neurochirurgica. Supplement
[ISO-abbreviation]
Acta Neurochir. Suppl.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Austria
52.
Momota H, Narita Y, Matsushita Y, Miyakita Y, Shibui S:
p53 abnormality and tumor invasion in patients with malignant astrocytoma.
Brain Tumor Pathol
; 2010 Oct;27(2):95-101
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
p53 abnormality and tumor invasion in patients with malignant
astrocytoma
.
To elucidate the relationship between p53 abnormality and invasiveness of the tumors, we studied mutation and protein expression of p53 in 48 consecutive patients with malignant
astrocytoma
(14
anaplastic
astrocytomas and 34 glioblastoma multiformes).
[MeSH-major]
Astrocytoma
/ genetics.
Astrocytoma
/ pathology.
Brain
Neoplasms / genetics.
Brain
Neoplasms / pathology. Genes, p53 / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 21046311.001).
[ISSN]
1861-387X
[Journal-full-title]
Brain tumor pathology
[ISO-abbreviation]
Brain Tumor Pathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / DNA, Neoplasm; 0 / Glial Fibrillary Acidic Protein; 0 / Tumor Suppressor Protein p53; 0 / Vascular Endothelial Growth Factor A
53.
Vidiri A, Carapella CM, Pace A, Mirri A, Fabi A, Carosi M, Giannarelli D, Pompili A, Jandolo B, Occhipinti E, Di Giovanni S, Crecco M:
Early post-operative MRI: correlation with progression-free survival and overall survival time in malignant gliomas.
J Exp Clin Cancer Res
; 2006 Jun;25(2):177-82
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Forty-seven patients with Glioblastoma (42) and
Anaplastic Astrocytoma
(5) were studied with MR 24 hrs after surgery.
[MeSH-major]
Brain
Neoplasms / mortality. Glioma / mortality. Magnetic Resonance Imaging
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - MRI Scans
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16918127.001).
[ISSN]
0392-9078
[Journal-full-title]
Journal of experimental & clinical cancer research : CR
[ISO-abbreviation]
J. Exp. Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Italy
54.
Robe PA, Martin DH, Nguyen-Khac MT, Artesi M, Deprez M, Albert A, Vanbelle S, Califice S, Bredel M, Bours V:
Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of sulfasalazine for the treatment of progressing malignant gliomas in adults.
BMC Cancer
; 2009;9:372
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
As it presents an excellent safety profile, we initiated a phase 1/2 clinical study of this anti-inflammatory drug for the treatment of recurrent WHO
grade
3 and 4 astrocytic gliomas in adults.
METHODS: 10 patients with advanced recurrent
anaplastic astrocytoma
(n = 2) or glioblastoma (n = 8) aged 32-62 years were recruited prior to the planned interim analysis of the study.
Side effects were common, as all patients developed
grade
1-3 adverse events (mean: 7.2/patient), four patients developed
grade
4 toxicity.
Hazardous Substances Data Bank.
SULFASALAZINE
.
ORBi (University of Liege).
Free full Text at ORBi
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Neurooncol. 2005 Sep;74(2):105-11
[
16193380.001
]
[Cites]
J Neurosci. 2005 Aug 3;25(31):7101-10
[
16079392.001
]
[Cites]
Physiol Rev. 2006 Jan;86(1):279-367
[
16371600.001
]
[Cites]
J Clin Oncol. 2006 Jan 10;24(2):274-87
[
16365179.001
]
[Cites]
BMC Cancer. 2006;6:29
[
16448552.001
]
[Cites]
Intern Med. 2006;45(15):927-9
[
16946577.001
]
[Cites]
Biochem Pharmacol. 2006 Oct 30;72(9):1054-68
[
16973133.001
]
[Cites]
Int J Oncol. 2007 Jan;30(1):283-90
[
17143539.001
]
[Cites]
Brain Tumor Pathol. 2005;22(2):79-87
[
18095109.001
]
[Cites]
Headache. 2008 Feb;48(2):296-8
[
18070060.001
]
[Cites]
Mol Cancer Res. 2008 Jan;6(1):21-30
[
18184972.001
]
[Cites]
J Cell Physiol. 2008 Jun;215(3):593-602
[
18181196.001
]
[Cites]
J Mol Diagn. 2008 Jul;10(4):332-7
[
18556773.001
]
[Cites]
Clin Neuropharmacol. 2008 Nov-Dec;31(6):368-71
[
19050416.001
]
[Cites]
Biochem Pharmacol. 2000 Oct 15;60(8):1085-9
[
11007945.001
]
[Cites]
Neurol Med Chir (Tokyo). 2001 Apr;41(4):187-95
[
11381677.001
]
[Cites]
J Neurosurg. 2002 May;96(5):909-17
[
12005399.001
]
[Cites]
Lab Invest. 2004 Aug;84(8):941-51
[
15184909.001
]
[Cites]
Clin Cancer Res. 2004 Aug 15;10(16):5595-603
[
15328202.001
]
[Cites]
J Clin Oncol. 1990 Jul;8(7):1277-80
[
2358840.001
]
[Cites]
J Neuroimmunol. 1991 Nov;34(2-3):109-20
[
1680877.001
]
[Cites]
Neurosci Res. 1992 Feb;13(1):1-17
[
1314349.001
]
[Cites]
Am J Gastroenterol. 1993 Oct;88(10):1759-63
[
8105680.001
]
[Cites]
Drugs. 1995 Jul;50(1):137-56
[
7588084.001
]
[Cites]
J Clin Invest. 1998 Jan 15;101(2):295-300
[
9435300.001
]
[Cites]
J Clin Invest. 1998 Mar 1;101(5):1163-74
[
9486988.001
]
[Cites]
Biochem Biophys Res Commun. 1998 Jun 9;247(1):79-83
[
9636658.001
]
[Cites]
J Immunol. 1998 Sep 15;161(6):2873-80
[
9743348.001
]
[Cites]
Brain Res. 1998 Aug 17;802(1-2):232-40
[
9748597.001
]
[Cites]
Oncogene. 1999 Apr 1;18(13):2261-71
[
10327072.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10):987-96
[
15758009.001
]
[Cites]
N Engl J Med. 2005 Mar 10;352(10):997-1003
[
15758010.001
]
[Cites]
Neuro Oncol. 2005 Oct;7(4):425-34
[
16212807.001
]
(PMID = 19840379.001).
[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Databank-accession-numbers]
ISRCTN/ ISRCTN45828668
[Publication-type]
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
3XC8GUZ6CB / Sulfasalazine
[Other-IDs]
NLM/ PMC2771045
55.
See SJ, Ty A, Wong MC:
Salvage chemotherapy in progressive high-grade astrocytoma.
Ann Acad Med Singapore
; 2007 May;36(5):343-6
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Salvage chemotherapy in progressive high-
grade
astrocytoma
.
INTRODUCTION: Despite aggressive multidisciplinary interventions, patients with high-
grade
astrocytomas experience tumour progression or recurrence.
MATERIALS AND METHODS: A retrospective review of relevant clinical and radiographic information of patients who received at least one cycle of salvage chemotherapy for progressive high-
grade
astrocytoma
at the National Cancer Center, Singapore, from March 2004 to September 2006, was conducted.
Patients underwent regular assessment with clinical examination and magnetic resonance
brain
imaging to gauge response to salvage chemotherapy.
RESULTS: Twenty-four patients (13 glioblastomas, 11
anaplastic
astrocytomas) had received chemotherapy as salvage treatment following progression of their high-
grade
astrocytoma
.
For patients with
anaplastic astrocytoma
, the 12-month survival rate was 73%.
CONCLUSION: Durable disease control and prolonged survival were seen in a significant portion of selected patients with progressive high-
grade
astrocytoma
who received salvage chemotherapy.
[MeSH-major]
Astrocytoma
/ drug therapy. Glioblastoma / drug therapy. Salvage Therapy / methods
[MeSH-minor]
Adult.
Brain
Neoplasms / drug therapy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Female. Humans. Male. Middle Aged. Retrospective Studies. Singapore. Survival Analysis
Hazardous Substances Data Bank.
DACARBAZINE
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17549281.001).
[ISSN]
0304-4602
[Journal-full-title]
Annals of the Academy of Medicine, Singapore
[ISO-abbreviation]
Ann. Acad. Med. Singap.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Singapore
[Chemical-registry-number]
7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
56.
Kumar R, Kamdar D, Madden L, Hills C, Crooks D, O'Brien D, Greenman J:
Th1/Th2 cytokine imbalance in meningioma, anaplastic astrocytoma and glioblastoma multiforme patients.
Oncol Rep
; 2006 Jun;15(6):1513-6
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Th1/Th2 cytokine imbalance in meningioma,
anaplastic astrocytoma
and glioblastoma multiforme patients.
Serum samples from 61 newly diagnosed patients with
brain
tumours and 50 age- and sex-matched non-tumour controls were analysed by ELISA for circulating levels of interleukin-12 (IL-12p70 and p40) and interleukin-10 (IL-10); pivotal Th1 and Th2 cytokines, respectively.
Patients were divided into various groups depending on their histological
diagnosis
: meningioma (n=11),
anaplastic astrocytoma
(n=4) and glioblastoma multiforme (GBM; n=46).
Significant reduction in serum IL-12 was seen in all groups as compared with the controls: meningioma, p=0.03;
anaplastic astrocytoma
, p<0.001; and GBM, p<0.001.
Conversely, serum IL-10 was significantly increased in
anaplastic astrocytoma
, p=0.02, and GBM, p=0.03.
This study shows that patients with advanced primary intracranial malignancies have decreased circulating IL-12 and increased circulating IL-10, demonstrating that
brain
tumours have a major systemic effect on the immune system.
[MeSH-major]
Astrocytoma
/ immunology.
Brain
Neoplasms / immunology. Glioblastoma / immunology. Interleukin-10 / blood. Interleukin-12 / blood. Meningioma / immunology. Th1 Cells / immunology. Th2 Cells / immunology
Genetic Alliance.
consumer health - Glioblastoma
.
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
Genetic Alliance.
consumer health - Meningioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16685388.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
130068-27-8 / Interleukin-10; 187348-17-0 / Interleukin-12
57.
Owen CM, Linskey ME:
Frame-based stereotaxy in a frameless era: current capabilities, relative role, and the positive- and negative predictive values of blood through the needle.
J Neurooncol
; 2009 May;93(1):139-49
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Diagnostic accuracy was calculated comparing biopsy
diagnosis
with final pathology in 11 patients who underwent subsequent surgical resection.
Of 18 lesions involving the corpus callosum, 13 (72.2%) were GBM 2 were
anaplastic astrocytoma
, and 1 each were found to be
anaplastic
oligodendroglioma, primary central nervous system lymphoma (PCNSL) and tumescent MS.
Of 25 multifocal lesions, malignant primary
brain
tumor was diagnosed in 17 (68%) (11 GBM, 3 PCNSL, 2
anaplastic
ologodendroglioma, and 1
anaplastic astrocytoma
).
CONCLUSIONS: Stereotactic biopsy is an effective, safe and important technique for histologic
diagnosis
of brain
lesions, particularly for multifocal and corpus callosum lesions.
[MeSH-major]
Biopsy, Needle / methods.
Brain
Diseases /
diagnosis
.
Brain
Diseases / surgery. Neuronavigation
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool.
Diagnosis
, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Young Adult
MedlinePlus Health Information.
consumer health - Brain Diseases
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Comput Aided Surg. 1998;3(2):51-6
[
9784952.001
]
[Cites]
Minim Invasive Neurosurg. 2002 Mar;45(1):11-5
[
11932818.001
]
[Cites]
Neurosurgery. 2001 Oct;49(4):830-5; discussion 835-7
[
11564243.001
]
[Cites]
Br J Neurosurg. 2006 Aug;20(4):222-6
[
16954072.001
]
[Cites]
Neurosurgery. 1996 Jan;38(1):170-6; discussion 176-8
[
8747966.001
]
[Cites]
Neurosurgery. 2006 Jul;59(1 Suppl 1):ONS146-56; discussion ONS146-56
[
16888546.001
]
[Cites]
Acta Neurochir Suppl (Wien). 1985;35:70-4
[
3911747.001
]
[Cites]
Ann Surg Oncol. 1994 Sep;1(5):368-72
[
7850537.001
]
[Cites]
AJNR Am J Neuroradiol. 1991 Nov-Dec;12 (6):1165-75
[
1763744.001
]
[Cites]
J Neurosurg. 2006 Feb;104(2):233-7
[
16509497.001
]
[Cites]
J Neurosurg. 1998 Jul;89(1):31-5
[
9647169.001
]
[Cites]
J Neurooncol. 2005 Jun;73(2):173-9
[
15981109.001
]
[Cites]
Appl Neurophysiol. 1982;45(4-5):426-30
[
7036878.001
]
[Cites]
Surg Neurol. 1984 Sep;22(3):222-30
[
6379944.001
]
[Cites]
Surg Neurol. 1980 Oct;14(4):275-83
[
7001660.001
]
[Cites]
J Neurosurg. 2005 May;102(5):897-901
[
15926716.001
]
[Cites]
Neurosurg Rev. 1994;17 (1):59-66
[
8078610.001
]
[Cites]
J Neurooncol. 2006 Jan;76(1):65-70
[
16132501.001
]
[Cites]
J Clin Neurosci. 2004 Apr;11(3):263-7
[
14975414.001
]
[Cites]
Neurosurgery. 1987 Jun;20(6):930-7
[
3302751.001
]
[Cites]
Neurosurgery. 1996 Nov;39(5):907-12; discussion 912-4
[
8905744.001
]
[Cites]
Neuro Oncol. 2001 Jul;3(3):193-200
[
11465400.001
]
[Cites]
Br J Neurosurg. 2002 Apr;16(2):110-8
[
12046728.001
]
[Cites]
J Neurosurg. 1994 Aug;81(2):165-8
[
8027795.001
]
[Cites]
Neurol Res. 2005 Jun;27(4):358-62
[
15949232.001
]
[Cites]
J Neurosurg. 2002 Aug;97(2):370-87
[
12186466.001
]
[Cites]
Neurosurgery. 1994 Oct;35(4):682-94; discussion 694-5
[
7808612.001
]
[Cites]
J Neurosurg. 2001 Apr;94(4):545-51
[
11302651.001
]
[Cites]
J Neurosurg. 1999 Jan;90(1):160-8
[
10413173.001
]
[Cites]
Neurosurgery. 1983 Mar;12 (3):277-85
[
6341870.001
]
[Cites]
Surg Neurol. 2001 Dec;56(6):366-71; discussion 371-2
[
11755966.001
]
[Cites]
Acta Neurochir (Wien). 1981;57(3-4):213-34
[
6269368.001
]
(PMID = 19430891.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
United States
[Number-of-references]
33
58.
Ooba H, Abe T, Kamida T, Anan M, Momii Y, Tokuuye K, Fujiki M:
Malignant fibrous histiocytosis after high-dose proton radiation therapy for anaplastic astrocytoma.
J Clin Neurosci
; 2009 Dec;16(12):1641-3
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Malignant fibrous histiocytosis after high-dose proton radiation therapy for
anaplastic astrocytoma
.
This report presents a 70-year-old male who presented with a rare malignant fibrous histiocytosis after high-dose proton radiation therapy for
anaplastic astrocytoma
.
[MeSH-minor]
Aged.
Astrocytoma
/ radiotherapy.
Brain
Neoplasms / radiotherapy. Humans. Magnetic Resonance Imaging / methods. Male
Genetic Alliance.
consumer health - Histiocytosis
.
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19766005.001).
[ISSN]
1532-2653
[Journal-full-title]
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
[ISO-abbreviation]
J Clin Neurosci
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Scotland
59.
Ichimura K, Vogazianou AP, Liu L, Pearson DM, Bäcklund LM, Plant K, Baird K, Langford CF, Gregory SG, Collins VP:
1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomas.
Oncogene
; 2008 Mar 27;27(14):2097-108
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Total 1p deletions were rare (2%), however partial deletions involving 1p36 were frequently identified in
anaplastic
astrocytomas (22%) and glioblastomas (34%).
Our results indicate that 1p deletions are common
anaplastic
astrocytomas and glioblastomas but are distinct from the 1p abnormalities in oligodendrogliomas.
[MeSH-major]
Astrocytoma
/ genetics.
Brain
Neoplasms / genetics. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Glioblastoma / genetics
Genetics Home Reference.
consumer health - chromosome 1
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Neuropathol Exp Neurol. 1999 Nov;58(11):1170-83
[
10560660.001
]
[Cites]
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9821-6
[
8790415.001
]
[Cites]
Cancer Res. 2000 Jan 15;60(2):417-24
[
10667596.001
]
[Cites]
Hum Mol Genet. 2000 May 22;9(9):1433-42
[
10814707.001
]
[Cites]
J Neurosurg. 2000 Jun;92(6):983-90
[
10839259.001
]
[Cites]
J Neuropathol Exp Neurol. 2000 Jun;59(6):544-58
[
10850867.001
]
[Cites]
J Clin Oncol. 2001 Jan 15;19(2):509-18
[
11208845.001
]
[Cites]
Am J Pathol. 2001 Apr;158(4):1253-62
[
11290543.001
]
[Cites]
Cell Growth Differ. 2001 Apr;12(4):201-10
[
11331249.001
]
[Cites]
Int J Oncol. 2001 Sep;19(3):609-12
[
11494043.001
]
[Cites]
J Neuropathol Exp Neurol. 2001 Sep;60(9):863-71
[
11556543.001
]
[Cites]
Clin Cancer Res. 2002 Jan;8(1):196-201
[
11801559.001
]
[Cites]
J Neuropathol Exp Neurol. 2002 Apr;61(4):321-8
[
11939587.001
]
[Cites]
Am J Pathol. 2002 Jul;161(1):313-9
[
12107116.001
]
[Cites]
Cancer Genet Cytogenet. 2002 Jun;135(2):147-59
[
12127399.001
]
[Cites]
Acta Neuropathol. 2002 Oct;104(4):357-62
[
12200621.001
]
[Cites]
Nat Med. 1997 Jun;3(6):682-5
[
9176498.001
]
[Cites]
Genes Chromosomes Cancer. 1998 May;22(1):9-15
[
9591629.001
]
[Cites]
Oncogene. 1999 Jul 15;18(28):4144-52
[
10435596.001
]
[Cites]
J Neurooncol. 2004 Nov;70(2):137-60
[
15674475.001
]
[Cites]
Clin Cancer Res. 2005 Feb 1;11(3):1119-28
[
15709179.001
]
[Cites]
Annu Rev Immunol. 2005;23:23-68
[
15771565.001
]
[Cites]
Cancer Res. 2005 Apr 1;65(7):2653-61
[
15805262.001
]
[Cites]
Adv Cancer Res. 2005;94:29-86
[
16095999.001
]
[Cites]
Ann Neurol. 2005 Sep;58(3):483-7
[
16130103.001
]
[Cites]
J Mol Med (Berl). 2005 Nov;83(11):917-26
[
16133418.001
]
[Cites]
Oncogene. 2006 Feb 23;25(8):1261-71
[
16205629.001
]
[Cites]
Nature. 2006 May 18;441(7091):315-21
[
16710414.001
]
[Cites]
J Clin Oncol. 2006 Jun 20;24(18):2707-14
[
16782910.001
]
[Cites]
J Clin Oncol. 2006 Jun 20;24(18):2715-22
[
16782911.001
]
[Cites]
J Neuropathol Exp Neurol. 2006 Sep;65(9):846-54
[
16957578.001
]
[Cites]
J Neuropathol Exp Neurol. 2006 Oct;65(10):988-94
[
17021403.001
]
[Cites]
Cancer Res. 2006 Oct 15;66(20):9852-61
[
17047046.001
]
[Cites]
Cell. 2007 Feb 9;128(3):459-75
[
17289567.001
]
[Cites]
J Neuropathol Exp Neurol. 2007 Jun;66(6):545-51
[
17549014.001
]
[Cites]
Genes Chromosomes Cancer. 2002 Oct;35(2):170-5
[
12203781.001
]
[Cites]
J Urol. 2003 Mar;169(3):1138-42
[
12576869.001
]
[Cites]
J Neuropathol Exp Neurol. 2003 Feb;62(2):111-26
[
12578221.001
]
[Cites]
Genes Chromosomes Cancer. 2003 Apr;36(4):361-74
[
12619160.001
]
[Cites]
Cancer. 2003 May 1;97(9):2254-61
[
12712480.001
]
[Cites]
Brain Pathol. 2003 Oct;13(4):507-18
[
14655756.001
]
[Cites]
Mod Pathol. 2004 Jun;17(6):617-22
[
15133472.001
]
[Cites]
Brain Pathol. 2004 Apr;14(2):121-30
[
15193024.001
]
[Cites]
Br J Cancer. 2004 Sep 13;91(6):1105-11
[
15475940.001
]
[Cites]
Cancer Res. 1988 Jan 15;48(2):405-11
[
3335011.001
]
[Cites]
J Clin Oncol. 2000 Feb;18(3):636-45
[
10653879.001
]
(PMID = 17934521.001).
[ISSN]
1476-5594
[Journal-full-title]
Oncogene
[ISO-abbreviation]
Oncogene
[Language]
eng
[Grant]
United Kingdom / Cancer Research UK / / A6618; United Kingdom / Cancer Research UK / / ; United Kingdom / Wellcome Trust / /
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC2650419; NLM/ UKMS4022
60.
Peria FM, Neder L, Marie SK, Rosemberg S, Oba-Shinjo SM, Colli BO, Gabbai AA, Malheiros SM, Zago MA, Panepucci RA, Moreira-Filho CA, Okamoto OK, Carlotti CG Jr:
Pleiotrophin expression in astrocytic and oligodendroglial tumors and it's correlation with histological diagnosis, microvascular density, cellular proliferation and overall survival.
J Neurooncol
; 2007 Sep;84(3):255-61
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Pleiotrophin expression in astrocytic and oligodendroglial tumors and it's correlation with histological
diagnosis
, microvascular density, cellular proliferation and overall survival.
There is evidence that PTN has also a relevant role in primary
brain
neoplasms and its inactivation could be important to treatment response.
Astrocytic and oligodendroglial tumors are the most frequent primary
brain
neoplasms.
Astrocytic tumors are classified as pilocytic
astrocytoma
(PA), diffuse
astrocytoma
(DA),
anaplastic astrocytoma
(AA) and glioblastoma (GBM).
Oligodendroglial tumors are classified as oligodendroglioma (O) and
anaplastic
oligodendroglioma (AO).
The aim of the present study was to compare PTN expression, in astrocytomas and oligodendrogliomas and its association with the histological
diagnosis
, microvascular density, proliferate potential and clinical outcome.
The histological
diagnosis
in accordance with WHO classification was: 13PA, 18DA, 8AA, 15GBM, 16O and 8AO.
Proliferate index and microvascular density were evaluated only in high
grade
tumors (AA, GBM and AO) divided in three groups according to PTN expression (low, intermediate and high).
Overall survival (OS) analysis (months) showed similar results in high
grade
gliomas with different levels of PTN expression.
CONCLUSIONS: Our results suggest that PTN expression is associated with histopathological
grade
of astrocytomas.
[MeSH-major]
Astrocytoma
/ pathology. Biomarkers, Tumor / analysis.
Brain
Neoplasms / pathology. Carrier Proteins / biosynthesis. Cytokines / biosynthesis. Oligodendroglioma / pathology
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Neuropathol Exp Neurol. 2002 Mar;61(3):215-25; discussion 226-9
[
11895036.001
]
[Cites]
FASEB J. 2004 Aug;18(11):1237-9
[
15180956.001
]
[Cites]
Biochem Biophys Res Commun. 2006 May 5;343(2):653-8
[
16554021.001
]
[Cites]
Growth Factors. 1994;10(2):89-98
[
7520717.001
]
[Cites]
J Biol Chem. 2002 Apr 19;277(16):14153-8
[
11809760.001
]
[Cites]
J Neurochem. 2006 Sep;98(5):1497-506
[
16923162.001
]
[Cites]
J Neuropathol Exp Neurol. 2003 Dec;62(12):1265-75
[
14692702.001
]
[Cites]
J Neurochem. 2002 Nov;83(4):747-53
[
12421346.001
]
[Cites]
Oncogene. 2003 Oct 2;22(43):6661-8
[
14555979.001
]
[Cites]
J Cutan Pathol. 2005 Feb;32(2):125-30
[
15606670.001
]
[Cites]
Cancer Lett. 2004 Feb 20;204(2):127-43
[
15013213.001
]
[Cites]
Gene Ther. 2005 Feb;12(4):339-46
[
15496960.001
]
[Cites]
J Biol Chem. 2006 Apr 21;281(16):10663-8
[
16507572.001
]
[Cites]
Arch Biochem Biophys. 2002 Jan 15;397(2):162-71
[
11795867.001
]
[Cites]
Cancer Res. 2003 Sep 15;63(18):5821-8
[
14522905.001
]
[Cites]
Curr Opin Oncol. 2004 Nov;16(6):607-13
[
15627025.001
]
[Cites]
J Biol Chem. 1990 Oct 5;265(28):16721-4
[
2170351.001
]
[Cites]
Cancer Res. 2006 Feb 15;66(4):2271-8
[
16489031.001
]
[Cites]
J Biol Chem. 2005 Jul 22;280(29):26953-64
[
15908427.001
]
[Cites]
Neurol Med Chir (Tokyo). 2004 Dec;44(12):637-43; discussion 644-5
[
15684595.001
]
[Cites]
Gynecol Oncol. 2003 Mar;88(3):289-97
[
12648577.001
]
[Cites]
Brain Res Dev Brain Res. 2004 Sep 17;152(2):189-97
[
15351507.001
]
[Cites]
J Biol Chem. 2002 Sep 27;277(39):35862-8
[
12107166.001
]
[Cites]
J Natl Cancer Inst. 1998 Oct 7;90(19):1468-73
[
9776412.001
]
[Cites]
J Biol Chem. 2005 Mar 11;280(10):9180-91
[
15632143.001
]
[Cites]
Br J Cancer. 2002 Mar 18;86(6):858-63
[
11953815.001
]
(PMID = 17443289.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Cytokines; 134034-50-7 / pleiotrophin
61.
Tsutsumi S, Abe Y, Yasumoto Y, Ito M:
Anaplastic pleomorphic xanthoastrocytoma with a component of anaplastic astrocytoma presenting as skull base tumor followed by downward extracranial extension. Case report.
Neurol Med Chir (Tokyo)
; 2010;50(12):1108-12
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Anaplastic
pleomorphic xanthoastrocytoma with a component
of anaplastic astrocytoma
presenting as skull base tumor followed by downward extracranial extension. Case report.
Histological examination revealed cellular pleomorphism with mitotic activity, focal necrosis, but lacking endothelial proliferation, consistent with
anaplastic
pleomorphic xanthoastrocytoma (PXA) with component
of anaplastic astrocytoma
.
PXA with
anaplastic
appearance may have a component
of anaplastic astrocytoma
with more aggressive behavior.
[MeSH-major]
Astrocytoma
/ pathology.
Brain
Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Skull Base Neoplasms / pathology
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
Genetic Alliance.
consumer health - Pleomorphic xanthoastrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 21206189.001).
[ISSN]
1349-8029
[Journal-full-title]
Neurologia medico-chirurgica
[ISO-abbreviation]
Neurol. Med. Chir. (Tokyo)
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
62.
Mennel HD, Lell B:
Ganglioside (GD2) expression and intermediary filaments in astrocytic tumors.
Clin Neuropathol
; 2005 Jan-Feb;24(1):13-8
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Intracranial supratentorial astrocytic gliomas of the adult represent a tumor group, that may be divided into three grades of malignancy, the most
anaplastic
member being the glioblastoma.
[MeSH-major]
Astrocytoma
/ metabolism.
Brain
Neoplasms / metabolism. Gangliosides / metabolism. Intermediate Filaments / metabolism
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 15696779.001).
[ISSN]
0722-5091
[Journal-full-title]
Clinical neuropathology
[ISO-abbreviation]
Clin. Neuropathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Gangliosides; 0 / Glial Fibrillary Acidic Protein; 0 / Vimentin; 65988-71-8 / ganglioside, GD2
63.
Kobayashi T, Masumoto J, Tada T, Nomiyama T, Hongo K, Nakayama J:
Prognostic significance of the immunohistochemical staining of cleaved caspase-3, an activated form of caspase-3, in gliomas.
Clin Cancer Res
; 2007 Jul 1;13(13):3868-74
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
The Kaplan-Meier method with the log-rank test revealed that patients with CC3 IRS-positive tumors had significantly greater survival than those with CC3 IRS-negative tumors among three grades, 2, 3, and 4 (P = 0.0061), and within
grade
3
of anaplastic astrocytoma
(P = 0.0458).
After adjustment for known clinical prognostic factors, such as age, WHO
grade
, and performance status, the hazard ratio for CC3 IRS-positive was 0.39 with 95% confidence interval between 0.19 and 0.85 (P = 0.0187).
[MeSH-major]
Brain
Neoplasms /
diagnosis
.
Brain
Neoplasms / metabolism. Caspase 3 / metabolism. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Glioma /
diagnosis
. Glioma / metabolism
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17606719.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
EC 3.4.22.- / Caspase 3
64.
Barnholtz-Sloan JS, Williams VL, Maldonado JL, Shahani D, Stockwell HG, Chamberlain M, Sloan AE:
Patterns of care and outcomes among elderly individuals with primary malignant astrocytoma.
J Neurosurg
; 2008 Apr;108(4):642-8
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Patterns of care and outcomes among elderly individuals with primary malignant
astrocytoma
.
OBJECT: This study was undertaken to evaluate the association between age at
diagnosis
, patterns of care, and outcome among elderly individuals with
anaplastic astrocytoma
(AA) and glioblastoma multiforme (GBM).
To facilitate gathering of prediagnosis comorbidity and postdiagnosis treatment information, only those individuals were included who had the same Medicare coverage for 6 months before and 12 months after
diagnosis
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[CommentIn]
J Neurosurg. 2012 Feb;116(2):355-6; discussion 356
[
21942728.001
]
[CommentIn]
J Neurosurg. 2008 Apr;108(4):639-40
[
18377239.001
]
(PMID = 18377240.001).
[ISSN]
0022-3085
[Journal-full-title]
Journal of neurosurgery
[ISO-abbreviation]
J. Neurosurg.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / K08 CA101954; United States / NCI NIH HHS / CA / K07-CA91849; United States / NCI NIH HHS / CA / K08-CA101954
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
65.
Volavsek M, Lamovec J, Popović M:
Extraneural metastases of anaplastic oligodendroglial tumors.
Pathol Res Pract
; 2009;205(7):502-7
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Extraneural metastases
of anaplastic
oligodendroglial tumors.
According to the literature, they tend to appear in glioblastoma patients, but are exceptionally rare in
anaplastic
oligodendroglioma.
We report on an
anaplastic
oligodendroglioma and an
anaplastic
oligoastrocytoma that metastasized to cervical lymph nodes and bones.
In the second case, metastases to the sacrum and femur developed after surgery for a recurrent
anaplastic
oligoastrocytoma.
Our two cases reconfirm a rare but definite ability not only of glioblastoma but also
of anaplastic
oligodendroglioma, namely to metastasize to extraneural sites.
It is important to bear this in mind, particularly in cases when the history of primary
brain
tumor is unavailable.
In such instances, the correct
diagnosis
of the metastatic lesion may be extremely difficult if not impossible.
[MeSH-major]
Astrocytoma
/ secondary.
Brain
Neoplasms / pathology. Femoral Neoplasms / secondary. Neoplasm Recurrence, Local. Oligodendroglia / pathology. Oligodendroglioma / secondary. Sacrum / pathology. Spinal Neoplasms / secondary
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19410385.001).
[ISSN]
1618-0631
[Journal-full-title]
Pathology, research and practice
[ISO-abbreviation]
Pathol. Res. Pract.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Germany
66.
Mizoguchi M, Betensky RA, Batchelor TT, Bernay DC, Louis DN, Nutt CL:
Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival.
J Neuropathol Exp Neurol
; 2006 Dec;65(12):1181-8
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor
grade
, and survival.
In this study, we investigated the activation status of these 3 signaling molecules as well as wild-type (EGFRwt) and mutant (EGFRvIII) EGFR in 82 malignant astrocytic gliomas (55 glioblastomas and 27
anaplastic
astrocytomas) using immunohistochemistry.
The distribution of these 3 activated molecules varied significantly with tumor
grade
; although activation of STAT3 was essentially identical between
anaplastic
astrocytomas and glioblastomas, an increase in the activation of MAPK and AKT appeared to correlate with the progression
of anaplastic astrocytoma
to glioblastoma.
[MeSH-major]
Astrocytoma
/ enzymology.
Brain
Neoplasms / enzymology. Glioblastoma / enzymology. Mitogen-Activated Protein Kinases / metabolism. Proto-Oncogene Proteins c-akt / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. STAT3 Transcription Factor / metabolism
[MeSH-minor]
Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism.
Diagnosis
, Differential. Disease Progression. Enzyme Activation / genetics. Genetic Predisposition to Disease / genetics. Humans. Immunohistochemistry. Mutation / genetics. Predictive Value of Tests. Prognosis. Signal Transduction / physiology. Survival Rate / trends. Transcriptional Activation / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17146292.001).
[ISSN]
0022-3069
[Journal-full-title]
Journal of neuropathology and experimental neurology
[ISO-abbreviation]
J. Neuropathol. Exp. Neurol.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA 57683; United States / NCI NIH HHS / CA / CA 95616
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
67.
Kim B, Chung CK, Myung JK, Park SH:
Pleomorphic xanthoastrocytoma associated with long-standing Taylor-type IIB-focal cortical dysplasia in an adult.
Pathol Res Pract
; 2009;205(2):113-7
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Brain
tumor in combination with cortical dysplasia is one of the causes of epilepsy, but coexistence of these two entities is a rare event.
Nine years ago (at the age of 45), a
brain
CT revealed a mass (1cm) in the uncal area, but the patient did not give consent to an operation.
The tumor was diagnosed as PXA with
anaplastic
feature (mitotic count: 5/10HPF), and the
brain
around the tumor showed dysmorphic neurons and balloon cells.
Therefore, the tumor was assumed to be associated with the
brain
, with Taylor-type-IIB focal cortical dysplasia.
[MeSH-major]
Astrocytoma
/ complications.
Astrocytoma
/ pathology.
Brain
Neoplasms / complications.
Brain
Neoplasms / pathology. Epilepsy, Temporal Lobe / complications. Malformations of Cortical Development / complications
Genetic Alliance.
consumer health - Pleomorphic xanthoastrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18657915.001).
[ISSN]
0344-0338
[Journal-full-title]
Pathology, research and practice
[ISO-abbreviation]
Pathol. Res. Pract.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
68.
Stettner MR, Wang W, Nabors LB, Bharara S, Flynn DC, Grammer JR, Gillespie GY, Gladson CL:
Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells.
Cancer Res
; 2005 Jul 1;65(13):5535-43
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
As we have found that Lyn, but not Fyn, activity promotes migration of glioblastoma cells in response to the cooperative signal generated by platelet-derived growth factor receptor beta and integrin alpha(v)beta3, we compared the activity and expression of Lyn and Fyn in glioblastoma (
grade
IV) tumor biopsy samples with that in
anaplastic astrocytoma
(
grade III
) tumors, nonneoplastic
brain
, and normal autopsy
brain
samples.
The levels of phosphorylation of the autophosphorylation site were consistent with significantly higher Lyn activity in glioblastoma tumor tissue than nonneoplastic
brain
.
Although the normalized levels of Lyn protein and the relative levels of Lyn message were significantly higher in glioblastoma samples than nonneoplastic
brain
, the normalized levels of Lyn protein did not correlate with Lyn activity in the glioblastoma samples.
There was no significant difference in the normalized levels of c-Src and Fyn protein and message in the glioblastoma and nonneoplastic
brain
.
[MeSH-major]
Brain
Neoplasms / enzymology. Glioblastoma / enzymology. src-Family Kinases / metabolism
[MeSH-minor]
Astrocytoma
/ enzymology.
Astrocytoma
/ genetics.
Astrocytoma
/ pathology. Biopsy.
Brain
/ enzymology. Endothelial Cells / enzymology. Humans. Immunohistochemistry. Phosphotransferases / genetics. Phosphotransferases / metabolism. Protein-Tyrosine Kinases. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-fyn. RNA, Messenger / genetics. RNA, Messenger / metabolism
Genetic Alliance.
consumer health - Glioblastoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 15994925.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA97110; United States / NCI NIH HHS / CA / P50 CA97247
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Proto-Oncogene Proteins; 0 / RNA, Messenger; EC 2.7.- / Phosphotransferases; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.2 / CSK tyrosine-protein kinase; EC 2.7.10.2 / FYN protein, human; EC 2.7.10.2 / Proto-Oncogene Proteins c-fyn; EC 2.7.10.2 / lyn protein-tyrosine kinase; EC 2.7.10.2 / src-Family Kinases
69.
Sanders RP, Kocak M, Burger PC, Merchant TE, Gajjar A, Broniscer A:
High-grade astrocytoma in very young children.
Pediatr Blood Cancer
; 2007 Dec;49(7):888-93
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
High-
grade
astrocytoma
in very young children.
BACKGROUND: High-
grade
astrocytomas are rare in young children, but have been reported to have a better prognosis than similar tumors in older patients.
PROCEDURE: We retrospectively reviewed the clinical characteristics, survival, and long-term sequelae for patients younger than 3 years old with high-
grade
astrocytoma
, treated at a single institution between 1984 and 2005.
Histology included
anaplastic astrocytoma
(n = 9), glioblastoma multiforme (n = 5), and malignant glioma (n = 2).
Age at
diagnosis
was a significant predictor of the hazard of death in a Cox model (HR 2.871, 95%CI 1.015-8.123).
All evaluable survivors (n = 9) had some neurocognitive impairment, with estimated overall cognitive ability ranging from significantly delayed to average; all survivors attending school (n = 5) performed below
grade
level on achievement testing.
CONCLUSIONS: Young children with high-
grade
astrocytoma
have better long-term overall survival than older patients, but recurrence is common, and most children require irradiation.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Astrocytoma
/ therapy.
Brain
Neoplasms / therapy
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Copyright]
2007 Wiley-Liss, Inc
[CommentIn]
Pediatr Blood Cancer. 2007 Dec;49(7):879-80
[
17941062.001
]
(PMID = 17554787.001).
[ISSN]
1545-5009
[Journal-full-title]
Pediatric blood & cancer
[ISO-abbreviation]
Pediatr Blood Cancer
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA 21765
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
70.
Parlato C, Barbarisi M, Moraci M, Moraci A:
Surgery, radiotherapy and temozolomide in treating high-grade gliomas.
Front Biosci
; 2006;11:1280-3
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Surgery, radiotherapy and temozolomide in treating high-
grade
gliomas.
Temozolomide (TMZ) a recent, oral, second generation alkylating agent is a chemotherapeutic with demonstrated efficacy for the treatment of high-
grade
gliomas.
Twelve patients with newly diagnosed glioblastoma (GBM), and
anaplastic astrocytoma
(AA) were studied.
Surgery allows to establish a histopathological
diagnosis
, to improve signs and symptoms which are attributable to intracranial hypertension or tumour topography, and to reduce the number of target cells for adjunctive therapies.
Temozolomide appears to be an ideal, first-line, single-agent, with a safe profile and demonstrated HQL benefits in patients with high-
grade
gliomas.
[MeSH-major]
Antineoplastic Agents, Alkylating / administration & dosage.
Brain
Neoplasms / therapy. Combined Modality Therapy / methods. Dacarbazine / analogs & derivatives. Glioma / therapy
[MeSH-minor]
Adult.
Astrocytoma
/ therapy. Clinical Trials as Topic. Disease Progression. Disease-Free Survival. Female. Glioblastoma / therapy. Humans. Male. Middle Aged. Quality of Life. Radiotherapy. Time Factors. Treatment Outcome
MedlinePlus Health Information.
consumer health - Brain Tumors
.
Hazardous Substances Data Bank.
DACARBAZINE
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16368514.001).
[ISSN]
1093-9946
[Journal-full-title]
Frontiers in bioscience : a journal and virtual library
[ISO-abbreviation]
Front. Biosci.
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
71.
MacDonald TJ, Pollack IF, Okada H, Bhattacharya S, Lyons-Weiler J:
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis.
Methods Mol Biol
; 2007;377:203-22
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Progression-associated genes in
astrocytoma
identified by novel microarray gene expression data reanalysis.
Astrocytoma
is graded as pilocytic (WHO
grade
I), diffuse (WHO
grade
II),
anaplastic
(WHO
grade III
), and glioblastoma multiforme (WHO
grade
IV).
The progression from low- to high-
grade
astrocytoma
is associated with distinct molecular changes that vary with patient age, yet the prognosis of high-
grade
tumors in children and adults is equally dismal.
Whether specific gene expression changes are consistently associated with all high-
grade
astrocytomas, independent of patient age, is not known.
We identified nine genes consistently dysregulated in high-
grade
tumors, using four novel tests for identifying differentially expressed genes.
Four genes encoding ribosomal proteins (RPS2, RPS8, RPS18, RPL37A) were upregulated, and five genes (APOD, SORL1, SPOCK2, PRSS11, ID3) were downregulated in high-
grade
by all tests.
Expression results were validated using a third
astrocytoma
dataset.
This suggests that dysregulation of APOD may be critical for malignant
astrocytoma
formation, and thus a possible novel universal target for therapeutic intervention.
Further investigation is needed to evaluate the role of APOD, as well as the other genes identified, in malignant
astrocytoma
development.
[MeSH-major]
Astrocytoma
/ genetics. Biomarkers, Tumor / genetics.
Brain
Neoplasms / genetics. Gene Expression. Oligonucleotide Array Sequence Analysis / methods
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17634619.001).
[ISSN]
1064-3745
[Journal-full-title]
Methods in molecular biology (Clifton, N.J.)
[ISO-abbreviation]
Methods Mol. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Number-of-references]
49
72.
Chamberlain MC, Chowdhary SA, Glantz MJ:
Anaplastic astrocytomas: biology and treatment.
Expert Rev Neurother
; 2008 Apr;8(4):575-86
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Anaplastic
astrocytomas: biology and treatment.
Anaplastic
astrocytomas (AA), WHO
grade III
gliomas, comprise 10-15% of all glial neoplasms.
The most important predictor of response to therapy and survival in AA tumors is the presence or absence of the 1p19q co-deletion, a translocation that defines a subset of oligodendroglial tumors, and
anaplastic
oligodendrogliomas in particular.
[MeSH-major]
Astrocytoma
/
diagnosis
.
Astrocytoma
/ therapy.
Brain
Neoplasms /
diagnosis
.
Brain
Neoplasms / therapy. Clinical Trials as Topic
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Clinical Trials
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18416660.001).
[ISSN]
1744-8360
[Journal-full-title]
Expert review of neurotherapeutics
[ISO-abbreviation]
Expert Rev Neurother
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
73.
Hoffman S, Propp JM, McCarthy BJ:
Temporal trends in incidence of primary brain tumors in the United States, 1985-1999.
Neuro Oncol
; 2006 Jan;8(1):27-37
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Temporal trends in incidence of primary
brain
tumors in the United States, 1985-1999.
A number of reports have indicated an increasing incidence of primary
brain
tumors over the past few decades.
The purpose of this study was to describe incidence rate trends in a population-based series of newly diagnosed primary nonmalignant and malignant
brain
and other CNS tumors, contributing five additional years to previously published incidence trends.
Data for the years 1985 through 1999 from six collaborating state cancer registries of the Central
Brain
Tumor Registry of the United States were used to determine incidence trends in the broad age groups 0-19, 20-64, and >or=65 years, overall and for selected histologies.
When
brain
lymphomas were excluded, this increase remained statistically significant.
A sharp change in incidence
of brain
lymphomas from increasing to decreasing over time was identified.
Specific histologies that were increasing included
anaplastic
astrocytomas in individuals aged >or=65 years, microscopically confirmed gliomas in both adult age groups, and microscopically confirmed glioma, not otherwise specified (NOS), in children.
Decreases were noted for
astrocytoma
, NOS, nonmicroscopically confirmed gliomas, and pituitary tumors.
Improvements in
diagnosis
and classification are likely reflected in the decreasing trends in unspecified glioma subgroups and the accompanying increasing trends in more specific glioma subgroups.
[MeSH-major]
Brain
Neoplasms / epidemiology
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
COS Scholar Universe.
author profiles
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Neuroepidemiology. 2004 May-Jun;23(3):101-9
[
15084778.001
]
[Cites]
Neuro Oncol. 2006 Jan;8(1):1-11
[
16443943.001
]
[Cites]
N Engl J Med. 1985 Oct 3;313(14):859-64
[
3897866.001
]
[Cites]
AJR Am J Roentgenol. 1986 Sep;147(3):453-5
[
3488645.001
]
[Cites]
J Natl Cancer Inst. 1990 Oct 17;82(20):1621-4
[
2213902.001
]
[Cites]
Am J Ind Med. 1991;19(4):421-31
[
2035544.001
]
[Cites]
CMAJ. 1991 Dec 15;145(12):1583-91
[
1742695.001
]
[Cites]
J Natl Cancer Inst. 1991 Nov 20;83(22):1679-81
[
1749021.001
]
[Cites]
Cancer. 1992 Mar 1;69(5):1300-6
[
1739929.001
]
[Cites]
J Natl Cancer Inst. 1992 Mar 18;84(6):442-5
[
1538422.001
]
[Cites]
Neurosurgery. 1992 Jul;31(1):78-82
[
1641113.001
]
[Cites]
Brain Pathol. 1993 Jul;3(3):255-68
[
8293185.001
]
[Cites]
Br J Cancer. 1994 Nov;70(5):973-9
[
7947107.001
]
[Cites]
Cancer. 1995 Jan 1;75(1 Suppl):330-7
[
8001004.001
]
[Cites]
Ann Neurol. 1995 Jan;37(1):67-73
[
7818260.001
]
[Cites]
Eur J Cancer. 1994;30A(10):1498-511
[
7833109.001
]
[Cites]
IARC Sci Publ. 1994;(128):1-302
[
7698823.001
]
[Cites]
Cancer. 1995 Nov 1;76(9):1634-42
[
8635069.001
]
[Cites]
Cancer. 1996 Aug 1;78(3):532-41
[
8697401.001
]
[Cites]
Paediatr Perinat Epidemiol. 1996 Jul;10(3):319-38
[
8822774.001
]
[Cites]
Int J Epidemiol. 1995 Dec;24(6):1078-85
[
8824847.001
]
[Cites]
Stat Med. 2000 Feb 15;19(3):335-51
[
10649300.001
]
[Cites]
Cancer. 2000 May 15;88(10):2342-9
[
10820357.001
]
[Cites]
N Engl J Med. 2001 Jan 11;344(2):79-86
[
11150357.001
]
[Cites]
J Neuropathol Exp Neurol. 2001 Mar;60(3):248-62
[
11245209.001
]
[Cites]
Neuro Oncol. 2001 Jul;3(3):141-51
[
11465394.001
]
[Cites]
Neuro Oncol. 1999 Jan;1(1):14-25
[
11554386.001
]
[Cites]
Brain Pathol. 2002 Apr;12(2):257-9
[
11958379.001
]
[Cites]
Neurology. 2002 Apr 23;58(8):1304-6
[
11971109.001
]
[Cites]
Cancer. 2002 Jul 1;95(1):193-202
[
12115333.001
]
[Cites]
J Neurooncol. 2002 Oct;60(1):61-9
[
12416547.001
]
[Cites]
J Neuropathol Exp Neurol. 2003 Feb;62(2):111-26
[
12578221.001
]
[Cites]
Neuroepidemiology. 2003 Mar-Apr;22(2):124-9
[
12629278.001
]
[Cites]
Int J Cancer. 2004 Jan 20;108(3):450-5
[
14648713.001
]
[Cites]
Neuroepidemiology. 2004 Jan-Apr;23(1-2):85-93
[
14739573.001
]
[Cites]
Am J Epidemiol. 2004 Feb 1;159(3):277-83
[
14742288.001
]
[Cites]
Cancer. 1997 Apr 1;79(7):1381-93
[
9083161.001
]
[Cites]
J Natl Cancer Inst. 1998 Sep 2;90(17):1269-77
[
9731733.001
]
[Cites]
J Natl Cancer Inst. 1999 Apr 7;91(7):648-9
[
10203289.001
]
[Cites]
AIDS. 1999 Jan 14;13(1):103-8
[
10207551.001
]
[Cites]
Cancer. 1999 May 1;85(9):2077-90
[
10223251.001
]
[Cites]
J Natl Cancer Inst. 1999 Jun 2;91(11):973-4
[
10359552.001
]
[Cites]
J Natl Cancer Inst. 1999 Aug 18;91(16):1382-90
[
10451443.001
]
[Cites]
Neurology. 1999 Sep 22;53(5):1141-3
[
10496285.001
]
[Cites]
Cancer. 2004 Nov 15;101(10):2293-9
[
15476282.001
]
[Cites]
Epidemiology. 2004 Nov;15(6):653-9
[
15475713.001
]
(PMID = 16443945.001).
[ISSN]
1522-8517
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Other-IDs]
NLM/ PMC1871920
74.
Watanabe T, Katayama Y, Komine C, Yoshino A, Ogino A, Ohta T, Fukushima T:
O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course.
Int J Cancer
; 2005 Feb 10;113(4):581-7
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
We analyzed the MGMT promoter methylation and TP53 mutations in 45 malignant astrocytomas (16
anaplastic
astrocytomas and 29 glioblastomas multiforme) treated prospectively with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-2(2-chloroethyl)-3-nitrosourea, interferon-beta and radiation therapy, and evaluated their clinical usefulness.
[MeSH-major]
Astrocytoma
/ genetics.
Brain
Neoplasms / genetics. DNA Methylation. Mutation / genetics. O(6)-Methylguanine-DNA Methyltransferase / genetics. Tumor Suppressor Protein p53 / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 15455376.001).
[ISSN]
0020-7136
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Tumor Suppressor Protein p53; 0S726V972K / Nimustine; 77238-31-4 / Interferon-beta; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase
75.
Tuominen H, Lohi J, Maiche A, Törmänen J, Baumann P:
Mediastinal metastasis of glioblastoma multiforme evolving from anaplastic astrocytoma.
J Neurooncol
; 2005 Nov;75(2):225-6
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Mediastinal metastasis of glioblastoma multiforme evolving from
anaplastic astrocytoma
.
[MeSH-major]
Astrocytoma
/ pathology.
Brain
Neoplasms / pathology. Glioblastoma / pathology. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / secondary
Genetic Alliance.
consumer health - Glioblastoma
.
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Cancer. 1985 Oct 1;56(7 Suppl):1778-82
[
4027909.001
]
[Cites]
Arch Anat Cytol Pathol. 1995;43(5-6):342-9
[
8729851.001
]
[Cites]
J Neurosurg. 1971 May;34(5):697-701
[
4326303.001
]
[Cites]
Digestion. 2000;61(3):219-22
[
10773729.001
]
[Cites]
Lancet Oncol. 2002 Aug;3(8):498-507
[
12147436.001
]
[Cites]
Cancer. 1980 Jan 1;45(1):112-25
[
6985826.001
]
[Cites]
J Am Acad Dermatol. 2002 Feb;46(2):297-300
[
11807444.001
]
[Cites]
J Neurosurg. 1969 Jul;31(1):50-8
[
4307543.001
]
[Cites]
J Neurooncol. 2001 Jun;53(2):107-14
[
11716064.001
]
[Cites]
J Neurosurg. 2000 Nov;93(5):887-90
[
11059674.001
]
(PMID = 16132499.001).
[ISSN]
0167-594X
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
United States
[Chemical-registry-number]
0 / Glial Fibrillary Acidic Protein
76.
da Fonseca CO, Linden R, Futuro D, Gattass CR, Quirico-Santos T:
Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol.
Arch Immunol Ther Exp (Warsz)
; 2008 Jul-Aug;56(4):267-76
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Intranasal delivery allows drugs that do not cross the blood-
brain
barrier to enter the central nervous system.
The cohort consisted of 37 patients, including 29 with glioblastoma multiforme (GBM), 5 with
grade III
astrocytoma
(AA), and 3 with
anaplastic
oligodendroglioma (AO).
[MeSH-major]
Antineoplastic Agents / therapeutic use.
Brain
Neoplasms / drug therapy. Glioma / drug therapy. Mitogen-Activated Protein Kinase Kinases / metabolism. Monoterpenes / therapeutic use. ras Proteins / metabolism
[MeSH-minor]
Administration, Intranasal. Adult. Aged. Apoptosis / drug effects.
Astrocytoma
/ drug therapy.
Astrocytoma
/ metabolism. Disease-Free Survival. Female. Glioblastoma / drug therapy. Glioblastoma / metabolism. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / metabolism. Oligodendroglioma / drug therapy. Oligodendroglioma / metabolism. Signal Transduction / drug effects
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Cancer Chemotherapy
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Cancer Res Clin Oncol. 2001 Feb;127(2):91-5
[
11216919.001
]
[Cites]
Cancer Res. 2001 Jun 1;61(11):4425-31
[
11389071.001
]
[Cites]
J Neurosurg. 2002 Mar;96(3):559-64
[
11892633.001
]
[Cites]
Int J Mol Med. 2002 Dec;10(6):785-8
[
12430008.001
]
[Cites]
Mol Carcinog. 2003 Jan;36(1):6-14
[
12503074.001
]
[Cites]
Brain Pathol. 2003 Jan;13(1):52-61
[
12580545.001
]
[Cites]
J Lipid Res. 2003 Jun;44(6):1209-15
[
12671036.001
]
[Cites]
Anticancer Drugs. 2004 Jun;15(5):513-23
[
15166627.001
]
[Cites]
Exp Biol Med (Maywood). 2004 Jul;229(7):567-85
[
15229351.001
]
[Cites]
Cancer Chemother Pharmacol. 2004 Oct;54(4):368-76
[
15205914.001
]
[Cites]
Mol Carcinog. 2004 Sep;41(1):39-53
[
15352124.001
]
[Cites]
Anticancer Res. 1998 Mar-Apr;18(2A):823-8
[
9615726.001
]
[Cites]
Cancer Res. 2005 Mar 1;65(5):1678-86
[
15753362.001
]
[Cites]
Oncol Rep. 2005 May;13(5):943-7
[
15809762.001
]
[Cites]
Surg Neurol. 2006;65 Suppl 1:S1:2-1:8; discussion S1:8-1:9
[
16427438.001
]
[Cites]
Clin Cancer Res. 2006 Jul 1;12(13):3882-9
[
16818682.001
]
[Cites]
Surg Neurol. 2006 Dec;66(6):611-5
[
17145324.001
]
[Cites]
Cancer Res. 2007 Mar 1;67(5):2098-106
[
17332339.001
]
[Cites]
Brain Pathol. 2007 Jul;17(3):319-24
[
17598825.001
]
[Cites]
Nat Rev Drug Discov. 2007 Jul;6(7):541-55
[
17585331.001
]
[Cites]
Acta Neuropathol. 2007 Aug;114(2):121-33
[
17588166.001
]
[Cites]
Cancer Invest. 2007 Sep;25(6):484-94
[
17882662.001
]
[Cites]
Cell Mol Life Sci. 2007 Oct;64(19-20):2575-89
[
17628742.001
]
[Cites]
Neurocirugia (Astur). 2007 Oct;18(5):373-82
[
18008011.001
]
[Cites]
Eur J Neurosci. 2007 Dec;26(11):3261-6
[
18005061.001
]
[Cites]
Cancer Invest. 2008 Apr-May;26(3):269-77
[
18317968.001
]
[Cites]
Cancer Chemother Pharmacol. 2008 Jun;62(1):149-57
[
17885756.001
]
[Cites]
Biochem Pharmacol. 2004 Nov 1;68(9):1739-47
[
15450939.001
]
[Cites]
Oncogene. 1997 Dec 4;15(23):2755-65
[
9419966.001
]
(PMID = 18726148.001).
[ISSN]
0004-069X
[Journal-full-title]
Archivum immunologiae et therapiae experimentalis
[ISO-abbreviation]
Arch. Immunol. Ther. Exp. (Warsz.)
[Language]
eng
[Publication-type]
Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Monoterpenes; 319R5C7293 / perilla alcohol; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 3.6.5.2 / ras Proteins
[Other-IDs]
NLM/ PMC2778682
77.
Dutta D, Vanere P, Gupta T, Munshi A, Jalali R:
Factors influencing activities of daily living using FIM-FAM scoring system before starting adjuvant treatment in patients with brain tumors: results from a prospective study.
J Neurooncol
; 2009 Aug;94(1):103-10
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Factors influencing activities of daily living using FIM-FAM scoring system before starting adjuvant treatment in patients with
brain
tumors: results from a prospective study.
BACKGROUND: Patients with
brain
tumors have varied degree of functional and psychological impairments because of factors relating to the tumor or to the treatment they receive.
MATERIAL AND METHOD: From August 2007 to April 2008, 150 consecutive adult (>18 years) primary
brain
tumor patients (median age 40 years; male 88, female 62) registered in a general out-patient neuro-oncology clinic were accrued and detailed data were recorded.
Seventy percent had malignant tumor (66% high-
grade
and 34% low-
grade
; 70% intra-axial).
Glioblastoma (GBM) (23.3%),
anaplastic astrocytoma
(AA) (18.7%), and diffuse fibrillary
astrocytoma
(18.7%) were the commonest histologic subtypes.
Univariate analysis showed total FIM-FAM scores not significantly different with age (< or =35 years vs. >35 years; P = 0.994), sex (male versus female; P = 0.133), and
grade
of the tumor (high-
grade
versus low-
grade
; P = 0.142) but were significantly higher in patients with a Karnofsky performance score (KPS) of > or =70 as compared with <70 (P = 0.001), neurological performance scale (NPS) of 0 or 1 vs. 2 or 3; P = 0.001), disease type (benign versus malignant; P = 0.001), and site of disease (cerebral versus cerebellar; P = 0.024).
[MeSH-major]
Activities of Daily Living / psychology.
Brain
Neoplasms / psychology. Disability Evaluation. Stress, Psychological / psychology
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Stress
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Clin Oncol (R Coll Radiol). 2000;12(1):36-41
[
10749018.001
]
[Cites]
J Neurooncol. 2008 Mar;87(1):111-4
[
18004503.001
]
[Cites]
Disabil Rehabil. 2004 Feb 18;26(4):235-45
[
15164957.001
]
[Cites]
Spinal Cord. 1997 Jan;35(1):22-5
[
9025215.001
]
[Cites]
Arch Phys Med Rehabil. 1993 Jun;74(6):566-73
[
8503745.001
]
[Cites]
J Neurol Neurosurg Psychiatry. 1999 Apr;66(4):480-4
[
10201420.001
]
[Cites]
J Neurooncol. 1997 Sep;34(2):187-92
[
9210067.001
]
[Cites]
J Neurooncol. 2008 Dec;90(3):321-8
[
18704269.001
]
[Cites]
Paraplegia. 1993 Jul;31(7):457-61
[
8371936.001
]
[Cites]
Am J Phys Med Rehabil. 1993 Apr;72(2):84-9
[
8476548.001
]
[Cites]
Disabil Rehabil. 1995 Jan;17(1):10-4
[
7858276.001
]
[Cites]
Scand J Caring Sci. 1990;4(3):99-106
[
2120762.001
]
[Cites]
Arch Phys Med Rehabil. 2001 Nov;82(11):1540-6
[
11689973.001
]
[Cites]
J Clin Oncol. 2000 Feb;18(3):646-50
[
10653880.001
]
[Cites]
J Clin Oncol. 1984 Mar;2(3):187-93
[
6699671.001
]
[Cites]
J Neurol. 2008 Jun;255(6):820-7
[
18500499.001
]
(PMID = 19255726.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
78.
Franceschi E, Cavallo G, Lonardi S, Magrini E, Tosoni A, Grosso D, Scopece L, Blatt V, Urbini B, Pession A, Tallini G, Crinò L, Brandes AA:
Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).
Br J Cancer
; 2007 Apr 10;96(7):1047-51
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Gefitinib in patients with progressive high-
grade
gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).
To investigate the role of gefitinib in patients with high-
grade
gliomas (HGGs), a phase II trial (1839IL/0116) was conducted in patients with disease recurrence following surgery plus radiotherapy and first-line chemotherapy.
Sixteen patients had glioblastoma, three patients had
anaplastic
oligodendrogliomas and nine patients had
anaplastic astrocytoma
.
No
grade
3-4 gefitinib-related toxicity was found.
[MeSH-major]
Antineoplastic Agents / therapeutic use.
Brain
Neoplasms / drug therapy. Glioma / drug therapy. Neoplasm Recurrence, Local / drug therapy. Quinazolines / therapeutic use
[MeSH-minor]
Adult. Aged.
Astrocytoma
/ drug therapy.
Astrocytoma
/ secondary. Disease-Free Survival. Female. Humans. Male. Maximum Tolerated Dose. Middle Aged. Neoplasm Staging. Oligodendroglioma / drug therapy. Oligodendroglioma / secondary. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Survival Rate. Treatment Outcome
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Cancer Chemotherapy
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Clin Oncol. 2004 Jan 1;22(1):133-42
[
14638850.001
]
[Cites]
N Engl J Med. 2004 May 20;350(21):2129-39
[
15118073.001
]
[Cites]
Science. 2004 Jun 4;304(5676):1497-500
[
15118125.001
]
[Cites]
J Natl Cancer Inst. 2004 Aug 4;96(15):1133-41
[
15292385.001
]
[Cites]
Science. 2004 Aug 20;305(5687):1163-7
[
15284455.001
]
[Cites]
Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11
[
15329413.001
]
[Cites]
Neurology. 2004 Sep 14;63(5):904-6
[
15365146.001
]
[Cites]
N Engl J Med. 2004 Sep 16;351(12):1260-1; author reply 1260-1
[
15376352.001
]
[Cites]
J Clin Oncol. 1990 Jul;8(7):1277-80
[
2358840.001
]
[Cites]
N Engl J Med. 2004 Dec 30;351(27):2883
[
15625347.001
]
[Cites]
Neurology. 2005 Apr 26;64(8):1444-5
[
15851741.001
]
[Cites]
J Natl Cancer Inst. 2005 May 4;97(9):643-55
[
15870435.001
]
[Cites]
J Natl Cancer Inst. 2005 Jun 15;97(12):880-7
[
15956649.001
]
[Cites]
N Engl J Med. 2005 Nov 10;353(19):2012-24
[
16282176.001
]
[Cites]
Clin Cancer Res. 2002 Nov;8(11):3496-502
[
12429640.001
]
[Cites]
Ann Oncol. 2003 Jun;14(6):922-30
[
12796031.001
]
[Cites]
J Clin Oncol. 2003 Jun 15;21(12):2237-46
[
12748244.001
]
[Cites]
Lancet Neurol. 2003 Jul;2(7):404-9
[
12849118.001
]
[Cites]
J Clin Oncol. 2003 Jul 15;21(14):2787-99
[
12860957.001
]
[Cites]
J Clin Oncol. 2003 Oct 15;21(20):3798-807
[
12953099.001
]
[Cites]
JAMA. 2003 Oct 22;290(16):2149-58
[
14570950.001
]
(PMID = 17353924.001).
[ISSN]
0007-0920
[Journal-full-title]
British journal of cancer
[ISO-abbreviation]
Br. J. Cancer
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Journal Article; Multicenter Study
[Publication-country]
England
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Quinazolines; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
[Other-IDs]
NLM/ PMC2360116
79.
Grossman SA, Alavi JB, Supko JG, Carson KA, Priet R, Dorr FA, Grundy JS, Holmlund JT:
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas.
Neuro Oncol
; 2005 Jan;7(1):32-40
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-alpha delivered as a 21-day continuous intravenous infusion in patients with recurrent high-
grade
astrocytomas.
In this phase 2 study, aprinocarsen was administered to patients with recurrent high-
grade
gliomas by continuous intravenous infusion (2.0 mg/kg/day for 21 days per month).
Their median age was 46 years (range, 28-68 years), median Karnofsky performance status was 80 (range, 60-100), median tumor volume was 58 cm3 (range, 16-254 cm3), and histology included glioblastoma multiforme (n = 16),
anaplastic
oligodendroglioma (n = 4), and
anaplastic astrocytoma
(n = 1).
The observed toxicities were mild, reversible, and uncommon (
grade
3 thrombocytopenia [n = 3] and
grade
4 AST [n = 1]), and no coagulopathy or CNS bleeding resulted from this therapy.
This is the first study to use an antisense oligonucleotide or a specific PKC-alpha inhibitor in patients with high-
grade
gliomas.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Mol Pharmacol. 1996 Aug;50(2):236-42
[
8700129.001
]
[Cites]
Glia. 1999 Feb 1;25(3):240-6
[
9932870.001
]
[Cites]
J Biopharm Stat. 1997 Mar;7(1):171-8
[
9056596.001
]
[Cites]
J Clin Oncol. 1997 Sep;15(9):3121-8
[
9294475.001
]
[Cites]
J Biol Chem. 1998 Mar 13;273(11):6001-4
[
9497312.001
]
[Cites]
J Clin Oncol. 1999 Nov;17(11):3586-95
[
10550158.001
]
[Cites]
Clin Cancer Res. 1999 Nov;5(11):3357-63
[
10589745.001
]
[Cites]
Prog Neurobiol. 2001 Feb;63(3):321-36
[
11115728.001
]
[Cites]
Curr Oncol Rep. 2000 Sep;2(5):445-53
[
11122877.001
]
[Cites]
Neurosci Lett. 2001 Jan 19;297(3):163-6
[
11137753.001
]
[Cites]
Brain Res Mol Brain Res. 2001 Nov 1;95(1-2):110-6
[
11687282.001
]
[Cites]
Curr Oncol Rep. 2002 Jan;4(1):37-46
[
11734112.001
]
[Cites]
Expert Opin Investig Drugs. 2001 Dec;10(12):2117-40
[
11772309.001
]
[Cites]
J Neurol Neurosurg Psychiatry. 2002 Feb;72(2):262-5
[
11796780.001
]
[Cites]
Clin Cancer Res. 2002 Apr;8(4):1042-8
[
11948111.001
]
[Cites]
Neurosci Lett. 2002 May 17;324(2):105-8
[
11988338.001
]
[Cites]
Am J Physiol Renal Physiol. 2002 Aug;283(2):F309-18
[
12110515.001
]
[Cites]
Clin Cancer Res. 2002 Jul;8(7):2188-92
[
12114419.001
]
[Cites]
J Anat. 2002 Jun;200(6):617-27
[
12162729.001
]
[Cites]
J Anat. 2002 Jun;200(6):639-46
[
12162731.001
]
[Cites]
Neuro Oncol. 2003 Apr;5(2):96-103
[
12672281.001
]
[Cites]
Lancet Neurol. 2003 Jul;2(7):404-9
[
12849118.001
]
[Cites]
Clin Cancer Res. 2003 Aug 1;9(8):2940-9
[
12912940.001
]
[Cites]
J Pharm Sci. 1985 Feb;74(2):229-31
[
3989700.001
]
[Cites]
Chem Pharm Bull (Tokyo). 1985 Apr;33(4):1620-32
[
4042238.001
]
[Cites]
Biochem Biophys Res Commun. 1987 Oct 29;148(2):718-25
[
3689368.001
]
[Cites]
Nature. 1988 Aug 25;334(6184):661-5
[
3045562.001
]
[Cites]
Control Clin Trials. 1989 Mar;10(1):1-10
[
2702835.001
]
[Cites]
Cancer Res. 1989 Jun 15;49(12):3215-7
[
2720675.001
]
[Cites]
Biochem Biophys Res Commun. 1989 Sep 29;163(3):1377-83
[
2783141.001
]
[Cites]
Cancer Res. 1990 Feb 1;50(3):677-85
[
2297708.001
]
[Cites]
Br J Cancer. 1992 Jul;66(1):10-9
[
1637658.001
]
[Cites]
Pharmacol Ther. 1993 Sep;59(3):257-80
[
8309991.001
]
[Cites]
J Biol Chem. 1994 Jun 10;269(23):16416-24
[
7911467.001
]
[Cites]
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11762-6
[
7972137.001
]
[Cites]
Cancer Chemother Pharmacol. 1998;42(2):118-26
[
9654111.001
]
[Cites]
Anal Biochem. 1996 Mar 1;235(1):36-43
[
8850544.001
]
(PMID = 15701280.001).
[ISSN]
1522-8517
[Journal-full-title]
Neuro-oncology
[ISO-abbreviation]
Neuro-oncology
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / U01 CA062475; United States / NCI NIH HHS / CA / U01-CA-26406; United States / NCI NIH HHS / CA / UO1CA-62475
[Publication-type]
Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / Oligonucleotides, Antisense; 0 / Phosphorothioate Oligonucleotides; EC 2.7.11.13 / PRKCA protein, human; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / Protein Kinase C-alpha; FMT95051CQ / aprinocarsen
[Other-IDs]
NLM/ PMC1871621
80.
Reddy PS, Umesh S, Thota B, Tandon A, Pandey P, Hegde AS, Balasubramaniam A, Chandramouli BA, Santosh V, Rao MR, Kondaiah P, Somasundaram K:
PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value.
Cancer Biol Ther
; 2008 May;7(5):663-8
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
PBEF1/NAmPRTase/Visfatin: a potential malignant
astrocytoma
/glioblastoma serum marker with prognostic value.
Malignant astrocytomas comprise
anaplastic astrocytoma
(AA;
grade III
) and Glioblastoma (GBM;
grade
IV).
Further validation using real time RT-qPCR on an independent set of tumor samples (n=91) and normal
brain
samples (n=9), GBM specific higher expression of PBEF1 was confirmed.
We carried out ELISA analysis on serum samples
of astrocytoma
patients to determine whether this protein levels would correlate with the presence of tumor and tumor
grade
.
Statistical analysis of these data indicates that in patients with
astrocytoma
, serum PBEF1 levels correlate with tumor
grade
and is highest in GBM.
Thus, we have identified PBEF1 as a potential malignant
astrocytoma
serum marker and prognostic indicator among GBMs.
[MeSH-major]
Astrocytoma
/ metabolism. Biomarkers, Tumor.
Brain
/ metabolism.
Brain
Neoplasms / metabolism. Cytokines / physiology. Gene Expression Regulation, Neoplastic. Glioblastoma / metabolism. Nicotinamide Phosphoribosyltransferase / metabolism
Genetic Alliance.
consumer health - Glioblastoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18728403.001).
[ISSN]
1555-8576
[Journal-full-title]
Cancer biology & therapy
[ISO-abbreviation]
Cancer Biol. Ther.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cytokines; 0 / Tumor Suppressor Protein p53; EC 2.4.2.12 / Nicotinamide Phosphoribosyltransferase; EC 2.4.2.12 / nicotinamide phosphoribosyltransferase, human
81.
Chaichana KL, Parker SL, Olivi A, Quiñones-Hinojosa A:
Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article.
J Neurosurg
; 2009 Aug;111(2):282-92
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Long-term seizure outcomes in adult patients undergoing primary resection of malignant
brain
astrocytomas. Clinical article.
METHODS: Cases involving adult patients who underwent primary resection of a hemispheric
anaplastic astrocytoma
(AA) or glioblastoma multiforme (GBM) at the Johns Hopkins Medical Institutions between 1996 and 2006 were retrospectively reviewed.
Among those patients with a history of seizures, outcome 12 months after surgery was Engel Class I (seizure free) in 77%, Class II (rare seizures) in 12%, Class
III
(meaningful improvement) in 6%, and Class IV (no improvement) in 5%.
[MeSH-major]
Astrocytoma
/ surgery.
Brain
Neoplasms / surgery. Seizures / etiology
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Seizures
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19344222.001).
[ISSN]
0022-3085
[Journal-full-title]
Journal of neurosurgery
[ISO-abbreviation]
J. Neurosurg.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
82.
Sega S, Horvat A, Popovic M:
Anaplastic oligodendroglioma and gliomatosis type 2 in interferon-beta treated multiple sclerosis patients. Report of two cases.
Clin Neurol Neurosurg
; 2006 Mar;108(3):259-65
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Anaplastic
oligodendroglioma and gliomatosis type 2 in interferon-beta treated multiple sclerosis patients. Report of two cases.
The concurrence of multiple sclerosis (MS) and
brain
tumors has been reported, but it is not known whether MS patients are at greater risk of harbouring the latter.
The most common cerebral neoplasms reported in MS patients were oligodendroglioma,
astrocytoma
, glioblastoma and gliomatosis.
MS can also present as a mass lesion that mimics a
brain
tumor.
To establish the correct
diagnosis
radiological follow-up and/or histological confirmation is needed.
Two cases of coincidental MS and
brain
tumors are reviewed.
One is a 26-year-old woman with relapsing-remitting MS and an
anaplastic
oligodendroglioma, the other a 49-year-old woman patient with relapsing-remitting MS and gliomatosis type 2.
The concurrence of MS and
brain
tumors could be purely coincidental, or the result of neoplastic transformation of reactive glial cells in the areas of demyelination.
The combination of a
brain
tumor and MS, and interferon-beta treatment could also be pure coincidence or an unknown side effect of treatment.
[MeSH-major]
Brain
Neoplasms / complications. Glioblastoma / complications. Multiple Sclerosis, Relapsing-Remitting / complications. Oligodendroglioma / complications
Genetic Alliance.
consumer health - Anaplastic Oligodendroglioma
.
Genetic Alliance.
consumer health - Multiple Sclerosis
.
Genetic Alliance.
consumer health - Oligodendroglioma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
Hazardous Substances Data Bank.
Interferon Beta-1b
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16378678.001).
[ISSN]
0303-8467
[Journal-full-title]
Clinical neurology and neurosurgery
[ISO-abbreviation]
Clin Neurol Neurosurg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Adjuvants, Immunologic; 145155-23-3 / Interferon beta-1b; 77238-31-4 / Interferon-beta
83.
Khan MK, Hunter GK, Vogelbaum M, Suh JH, Chao ST:
Evidence-based adjuvant therapy for gliomas: current concepts and newer developments.
Indian J Cancer
; 2009 Apr-Jun;46(2):96-107
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
Of the 18,820 new cases of primary central nervous system (CNS) tumors diagnosed annually in the United States, gliomas account for over 60% with 30-40% of them being glioblastoma multiforme (GBM), 10% being
anaplastic astrocytoma
(AA), and 10% being low
grade
gliomas (LGGs).
This is in contrast to one study from West Bengal, India, in which only 7.9% of the
brain
tumors were GBMs, while 46.8% were astrocytomas.
Common to these approaches is the use of adjuvant radiation therapy, even as surgery alone, with or without chemotherapy, may be the mainstay for some lower
grade
and low-risk gliomas.
Specifically, the database is searched using the following keywords, with various combinations: glioma, low-
grade
,
anaplastic
,
astrocytoma
, oligodendroglioma, oligoastrocytoma, glioblastoma multiforme, chemotherapy, radiation, new concepts, phase
III
, MGMT, CDX-110 (Celldex), temozolomide, 1p/19q deletion, and bevacizumab.
[MeSH-minor]
Antineoplastic Agents / therapeutic use.
Astrocytoma
/ drug therapy.
Astrocytoma
/ radiotherapy.
Astrocytoma
/ therapy. Glioblastoma / drug therapy. Glioblastoma / radiotherapy. Glioblastoma / therapy. Humans
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 19346643.001).
[ISSN]
0019-509X
[Journal-full-title]
Indian journal of cancer
[ISO-abbreviation]
Indian J Cancer
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
India
[Chemical-registry-number]
0 / Antineoplastic Agents
[Number-of-references]
64
84.
Okazaki T, Kageji T, Matsuzaki K, Horiguchi H, Hirose T, Watanabe H, Ohnishi T, Nagahiro S:
Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature.
J Neurooncol
; 2009 Sep;94(3):431-7
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Primary
anaplastic
pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at
diagnosis
--a pediatric case report and review of the literature.
We report a 5 year-old boy with primary
anaplastic
pleomorphic xanthoastrocytoma (PXA) with whole neuroaxis dissemination at
diagnosis
who experienced the sudden onset of generalized convulsion.
Under a histopathologic
diagnosis
of anaplastic
PXA he underwent adjuvant chemotherapy consisting of 12 cycles of carboplatin and vincristine.
We report a very rare pediatric case of primary
anaplastic
PXA with dissemination involving the entire neuroaxis at the time of
diagnosis
.
[MeSH-major]
Astrocytoma
/
diagnosis
.
Brain
Neoplasms /
diagnosis
. Magnetic Resonance Imaging / methods. Neoplasms, Complex and Mixed /
diagnosis
[MeSH-minor]
Child, Preschool.
Diagnosis
, Differential. Head / diagnostic imaging. Head / pathology. Humans. Male. Spinal Cord / diagnostic imaging. Spinal Cord / pathology. Tomography, X-Ray Computed / methods
Genetic Alliance.
consumer health - Pleomorphic xanthoastrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
MedlinePlus Health Information.
consumer health - MRI Scans
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
J Neurosurg. 1997 May;86(5):747-54
[
9126887.001
]
[Cites]
Childs Nerv Syst. 2006 Nov;22(11):1479-82
[
17047968.001
]
[Cites]
Klin Padiatr. 2004 Nov-Dec;216(6):331-42
[
15565548.001
]
[Cites]
Cancer. 1999 May 1;85(9):2033-45
[
10223246.001
]
[Cites]
Pediatr Neurosurg. 2004 Jul-Aug;40(4):171-81
[
15608490.001
]
[Cites]
Pathol Int. 1999 Sep;49(9):811-5
[
10504553.001
]
[Cites]
J Neurol Sci. 2007 Jan 31;252(2):144-53
[
17189643.001
]
[Cites]
Childs Nerv Syst. 2006 Jun;22(6):614-8
[
16369851.001
]
[Cites]
Neuroradiology. 2004 Oct;46(10):825-9
[
15289955.001
]
[Cites]
Br J Neurosurg. 2006 Dec;20(6):433-4
[
17439101.001
]
[Cites]
Neuro Oncol. 2000 Oct;2(4):213-20
[
11265230.001
]
[Cites]
J Clin Neurosci. 2008 Apr;15(4):476-8
[
18255294.001
]
[Cites]
J Neurooncol. 2006 Sep;79(2):151-2
[
16850109.001
]
[Cites]
Childs Nerv Syst. 2006 Jun;22(6):609-13
[
16570197.001
]
[Cites]
J Clin Oncol. 2002 Oct 15;20(20):4209-16
[
12377964.001
]
[Cites]
Childs Nerv Syst. 2004 Feb;20(2):119-22
[
14669022.001
]
[Cites]
Acta Neurochir (Wien). 2006 Jan;148(1):67-71; discussion 71
[
15912255.001
]
[Cites]
J Neurosurg. 2005 Feb;102(2):376-81
[
15739569.001
]
[Cites]
Cancer. 1979 Nov;44(5):1839-52
[
498051.001
]
[Cites]
Histopathology. 1998 Apr;32(4):375-8
[
9602336.001
]
[Cites]
Pediatr Blood Cancer. 2007 Nov;49(6):808-11
[
17588234.001
]
[Cites]
Clin Neuropathol. 2008 Jul-Aug;27(4):234-40
[
18666439.001
]
[Cites]
J Neurooncol. 1997 May;32(3):235-41
[
9049885.001
]
[Cites]
J Clin Oncol. 2003 Dec 15;21(24):4572-8
[
14673044.001
]
[Cites]
Arq Neuropsiquiatr. 2003 Mar;61(1):104-6
[
12715030.001
]
[Cites]
Neurosurgery. 2005 Jul;57(1):E191; discussion E191
[
15987556.001
]
[Cites]
J Neurooncol. 2008 Dec;90(3):321-8
[
18704269.001
]
[Cites]
Histopathology. 2008 Jan;52(2):183-93
[
18184267.001
]
[Cites]
Neuro Oncol. 2007 Apr;9(2):161-8
[
17347491.001
]
[Cites]
Surg Neurol. 2007 Jul;68(1):89-94; discussion 94-5
[
17537486.001
]
[Cites]
Clin Neurol Neurosurg. 1997 Feb;99(1):40-5
[
9107467.001
]
[Cites]
Brain Tumor Pathol. 2006 Apr;23(1):55-63
[
18095120.001
]
[Cites]
J Neurol Sci. 2006 Aug 15;247(1):105-8
[
16725158.001
]
[Cites]
J Neurooncol. 2005 Dec;75(3):301-7
[
16195800.001
]
[Cites]
Childs Nerv Syst. 1999 Oct;15(10):506-13
[
10550582.001
]
[Cites]
J Neurosurg Spine. 2006 Jul;5(1):72-5
[
16850961.001
]
[Cites]
J Clin Oncol. 2002 Jul 1;20(13):2951-8
[
12089224.001
]
[Cites]
Clin Neuropathol. 2007 Jul-Aug;26(4):169-75
[
17702498.001
]
(PMID = 19326050.001).
[ISSN]
1573-7373
[Journal-full-title]
Journal of neuro-oncology
[ISO-abbreviation]
J. Neurooncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
United States
[Number-of-references]
41
85.
Jeannin S, Lebrun C, Van Den Bos F, Olschwang S, Bourg V, Frenay M:
[Turcot's syndrome confirmed by molecular biological tests].
Rev Neurol (Paris)
; 2006 Jun;162(6-7):741-6
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Transliterated title]
Syndrome
de
Turcot confirmé par biologie moléculaire.
INTRODUCTION: Turcot's syndrome is characterized clinically by the concurrence of a primary
brain
tumor and a familial adenomatous polyposis or a hereditary nonpolyposis colorectal cancer.
OBSERVATION: We report a case of a 45-year-old woman who underwent in 1995 neuro-oncological treatment for an
anaplastic astrocytoma
(
grade III
according to the World Health Organization classification).
Eight years after the
diagnosis
, the patient developed a gliomatosis cerebri and died.
CONCLUSION: Relevant personal and familial history can provide the clue to the
diagnosis
of Turcot's syndrome.
Molecular
diagnosis
may contribute to appropriate care of affected patients.
[MeSH-major]
Adenomatous Polyps / complications. Adenomatous Polyps / genetics.
Brain
Neoplasms / complications. Carrier Proteins / genetics. Colorectal Neoplasms / complications. Colorectal Neoplasms / genetics. DNA Mutational Analysis / methods. Glioma / complications. MutS Homolog 2 Protein / genetics. Nuclear Proteins / genetics
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Colorectal Cancer
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 16840983.001).
[ISSN]
0035-3787
[Journal-full-title]
Revue neurologique
[ISO-abbreviation]
Rev. Neurol. (Paris)
[Language]
fre
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
France
[Chemical-registry-number]
0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
86.
Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW, Anant S, Jenkins S, Eberhart CG, Sarkaria JN, Gutmann DH:
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.
J Neuropathol Exp Neurol
; 2008 Dec;67(12):1194-204
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Gene expression profiling of NF-1-associated and sporadic pilocytic
astrocytoma
identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes.
Pilocytic astrocytomas (PAs) are World Health Organization
Grade
I gliomas; they most often affect children and young adults and occur in patients with neurofibromatosis type 1 (NF1).
Furthermore, in an additional independent set of tumors, weak to absent ALDH1L1 expression was found in 13 (72%) of 18 clinically aggressive PAs, in 8 (89%) of 9 PAs with pilomyxoid features, in 7 (70%) of 10 PAs with
anaplastic
transformation, and in 16 (76%) of 21 diffusely infiltrating astrocytomas of various grades.
Genetic Alliance.
consumer health - Pilocytic astrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
COS Scholar Universe.
author profiles
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Biochem Biophys Res Commun. 2002 Sep 13;297(1):148-53
[
12220523.001
]
[Cites]
Neurology. 2006 Jan 10;66(1):127-30
[
16401863.001
]
[Cites]
J Neurosurg. 2003 Jun;98(6):1170-4
[
12816259.001
]
[Cites]
Arch Ophthalmol. 2001 Apr;119(4):516-29
[
11296017.001
]
[Cites]
J Neuropathol Exp Neurol. 2001 Sep;60(9):917-20
[
11556548.001
]
[Cites]
Clin Cancer Res. 2001 Dec;7(12):4073-9
[
11751504.001
]
[Cites]
Cancer Res. 2002 Apr 1;62(7):2085-91
[
11929829.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):996-1001
[
11958894.001
]
[Cites]
Cell Growth Differ. 2002 May;13(5):227-36
[
12065246.001
]
[Cites]
J Neuropathol Exp Neurol. 2006 Nov;65(11):1049-58
[
17086101.001
]
[Cites]
J Comp Neurol. 2007 Jan 10;500(2):368-83
[
17111379.001
]
[Cites]
Cancer Res. 2007 Feb 1;67(3):890-900
[
17283119.001
]
[Cites]
Neuropediatrics. 2007 Apr;38(2):61-3
[
17712732.001
]
[Cites]
J Neurooncol. 2008 Jan;86(2):183-90
[
17690840.001
]
[Cites]
J Neurosci. 2008 Jan 2;28(1):264-78
[
18171944.001
]
[Cites]
J Neuropathol Exp Neurol. 2008 Mar;67(3):240-9
[
18344915.001
]
[Cites]
J Clin Invest. 2008 May;118(5):1739-49
[
18398503.001
]
[Cites]
Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1235-44
[
18325984.001
]
[Cites]
Oncogene. 2008 Aug 7;27(34):4745-51
[
18408760.001
]
[Cites]
Carcinogenesis. 2008 Jul;29(7):1394-9
[
18550570.001
]
[Cites]
J Neuropathol Exp Neurol. 2008 Sep;67(9):878-87
[
18716556.001
]
[Cites]
Eur Arch Otorhinolaryngol. 2009 Jan;266(1):89-96
[
18427826.001
]
[Cites]
Liver Int. 2009 Feb;29(2):187-95
[
18694400.001
]
[Cites]
J Clin Oncol. 2003 Aug 1;21(15):2968-73
[
12885817.001
]
[Cites]
Ann N Y Acad Sci. 2003 Dec;1010:504-9
[
15033780.001
]
[Cites]
Melanoma Res. 2004 Feb;14(1):29-37
[
15091191.001
]
[Cites]
Brain Pathol. 2004 Jul;14(3):297-303
[
15446585.001
]
[Cites]
J Biol Chem. 1989 Jan 5;264(1):328-33
[
2909524.001
]
[Cites]
Cancer Res. 1991 May 1;51(9):2291-5
[
1707749.001
]
[Cites]
Cancer. 1993 Aug 15;72(4):1335-42
[
8339223.001
]
[Cites]
Hum Pathol. 1995 Sep;26(9):979-86
[
7672798.001
]
[Cites]
JAMA. 1997 Jul 2;278(1):51-7
[
9207339.001
]
[Cites]
J Neurooncol. 1998 Mar;37(1):9-16
[
9525833.001
]
[Cites]
Hum Pathol. 1998 Dec;29(12):1511-6
[
9865840.001
]
[Cites]
J Neuropathol Exp Neurol. 1999 Jan;58(1):46-53
[
10068313.001
]
[Cites]
J Neuropathol Exp Neurol. 1999 Oct;58(10):1061-8
[
10515229.001
]
[Cites]
Oncogene. 2004 Nov 18;23(54):8796-804
[
15467732.001
]
[Cites]
Cancer Res. 2005 Jan 1;65(1):76-84
[
15665281.001
]
[Cites]
Cancer Res. 2005 Jan 1;65(1):236-45
[
15665300.001
]
[Cites]
J Neuropathol Exp Neurol. 2005 Jun;64(6):479-89
[
15977639.001
]
[Cites]
Biochem J. 2005 Nov 1;391(Pt 3):503-11
[
16014005.001
]
[Cites]
Neurology. 2005 Oct 25;65(8):1335-6
[
16247081.001
]
[Cites]
J Biol Chem. 2002 Sep 27;277(39):36216-22
[
12147692.001
]
(PMID = 19018242.001).
[ISSN]
0022-3069
[Journal-full-title]
Journal of neuropathology and experimental neurology
[ISO-abbreviation]
J. Neuropathol. Exp. Neurol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P50 CA108961; United States / NINDS NIH HHS / NS / T32 NS007494; United States / NINDS NIH HHS / NS / NS007494-05; United States / NINDS NIH HHS / NS / T32 NS07494-04; United States / NINDS NIH HHS / NS / T32 NS007494-05
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Isoenzymes; 0 / Nerve Tissue Proteins; EC 1.2.1.- / aldehyde dehydrogenase 1; EC 1.2.1.3 / Aldehyde Dehydrogenase; EC 1.2.1.36 / Retinal Dehydrogenase; EC 1.5.1.6 / ALDH1L1 protein, human
[Other-IDs]
NLM/ NIHMS87254; NLM/ PMC2730602
87.
Mikuni N, Hashimoto N:
A minimally invasive transsulcal approach to the paracentral inner lesion.
Minim Invasive Neurosurg
; 2006 Oct;49(5):291-5
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
METHODS: Four patients with paracentral inner lesions including
anaplastic astrocytoma
, cortical dysplasia, and cavernous angioma were operated on.
[MeSH-major]
Astrocytoma
/ surgery.
Brain
Diseases / surgery.
Brain
Neoplasms / surgery. Hemangioma, Cavernous / surgery. Intralaminar Thalamic Nuclei / surgery. Minimally Invasive Surgical Procedures / methods. Neurosurgical Procedures / methods
[MeSH-minor]
Adult.
Brain
Mapping. Consciousness / physiology. Evoked Potentials, Motor / physiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged
MedlinePlus Health Information.
consumer health - Brain Diseases
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 17163343.001).
[ISSN]
0946-7211
[Journal-full-title]
Minimally invasive neurosurgery : MIN
[ISO-abbreviation]
Minim Invasive Neurosurg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Germany
88.
Arai Y, Tsuchida T, Tanioka F, Sugimura H, Watanabe C, Hongo T, Tsutsui Y:
Congenital anaplastic astrocytoma differentiated into pilocytic astrocytoma: an autopsy case.
Neuropathology
; 2008 Aug;28(4):433-9
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Congenital
anaplastic astrocytoma
differentiated into pilocytic
astrocytoma
: an autopsy case.
We report an autopsy case of congenital
astrocytoma
and its histopathological changes during 5 years of the patient's development from birth to death.
The right orbital tumor, which was enucleated at 2 months of age, was a highly cellular tumor with moderate pleomorphism resembling
anaplastic astrocytoma
.
On the other hand, at autopsy, a
brain
tumor was found in the right diencephalic region with features of pilocytic
astrocytoma
, accompanied by leptomeningeal dissemination.
A biopsy specimen, which was obtained from the chiasmatic part of the tumor at 4 months of age, showed an intermediate appearance between the orbital tumor and the
brain
tumor obtained at autopsy.
We believe that this congenital
anaplastic astrocytoma
differentiated into a pilocytic
astrocytoma
during the 5 years of the patient's development.
The transformation of the congenital
astrocytoma
from
anaplastic
to pilocytic forms can be attributed to the nature of the tumor, namely postmitotic neoplastic cells are characterized by their ability to undergo self-differentiation, along with the organotropism of the developing
brain
.
[MeSH-major]
Astrocytoma
/ congenital.
Astrocytoma
/ pathology.
Brain
Neoplasms / congenital.
Brain
Neoplasms / pathology
Genetic Alliance.
consumer health - Anaplastic Astrocytoma
.
Genetic Alliance.
consumer health - Pilocytic astrocytoma
.
MedlinePlus Health Information.
consumer health - Brain Tumors
.
MedlinePlus Health Information.
consumer health - Childhood Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 18282169.001).
[ISSN]
0919-6544
[Journal-full-title]
Neuropathology : official journal of the Japanese Society of Neuropathology
[ISO-abbreviation]
Neuropathology
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
89.
Elsir T, Eriksson A, Orrego A, Lindström MS, Nistér M:
Expression of PROX1 Is a common feature of high-grade malignant astrocytic gliomas.
J Neuropathol Exp Neurol
; 2010 Feb;69(2):129-38
[Fulltext service]
Get downloadable
fulltext PDFs
of
articles closely matching to this article
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Expression of PROX1 Is a common feature of high-
grade
malignant astrocytic gliomas.
An average of 79% of cells in World Health Organization
Grade
IV (glioblastoma, n = 15) and 57% of cells in World Health Organization
Grade III
(
anaplastic astrocytoma
, n = 13) were strongly PROX1 positive; low-
grade
diffuse astrocytomas (
Grade
II, n = 13) had 21% of cells that were strongly positive;
Grade
I tumors (n = 15) had 1.5%; and non-neoplastic
brain
tissue (n = 15) had 3.7% of cells that were PROX1 positive.
We conclude that PROX1 may constitute a useful tool for the
diagnosis
and grading ofastrocytic gliomas and for distinguishing
Grade III
and
Grade
IV tumors from
Grade
I and
Grade
II tumors.
[MeSH-major]
Astrocytoma
/ metabolism.
Astrocytoma
/ pathology.
Brain
Neoplasms / metabolism.
Brain
Neoplasms / pathology. Homeodomain Proteins / metabolism. Tumor Suppressor Proteins / metabolism
[MeSH-minor]
Antigens, Nuclear / metabolism. Biomarkers / metabolism.
Brain
Diseases / metabolism. Cell Proliferation. Humans. Immunohistochemistry. Microtubule-Associated Proteins / metabolism. Microvessels / metabolism. Mitosis. Nerve Tissue Proteins / metabolism. Tubulin / metabolism
MedlinePlus Health Information.
consumer health - Brain Tumors
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
(PMID = 20084020.001).
[ISSN]
1554-6578
[Journal-full-title]
Journal of neuropathology and experimental neurology
[ISO-abbreviation]
J. Neuropathol. Exp. Neurol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Nuclear; 0 / Biomarkers; 0 / Homeodomain Proteins; 0 / MAP2 protein, human; 0 / Microtubule-Associated Proteins; 0 / Nerve Tissue Proteins; 0 / Tubulin; 0 / Tumor Suppressor Proteins; 0 / neuronal nuclear antigen NeuN, human; 0 / prospero-related homeobox 1 protein
90.
Sathornsumetee S, Cao Y, Marcello JE, Herndon JE 2nd, McLendon RE, Desjardins A, Friedman HS, Dewhirst MW, Vredenburgh JJ, Rich JN:
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan.
J Clin Oncol
; 2008 Jan 10;26(2):271-8
[Fulltext service]
Download
fulltext PDF
of
this article and others
, as many as you want.
[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant
astrocytoma
patients treated with bevacizumab and irinotecan.
Tumor specimens collected at the time of
diagnosis
were available for further pathologic studies in 45 patients (75%).
RESULTS: Of 45 patients, 27 patients had glioblastoma multiforme, and 18 patients had
anaplastic astrocytoma
.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Astrocytoma
/ drug therapy.
Brain
Neoplasms / drug therapy
MedlinePlus Health Information.
consumer health - Brain Tumors
.
COS Scholar Universe.
author profiles
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
The Lens.
Cited by Patents in
.
[Email]
Email this result item
Email the results to the following email address:
[X] Close
[Cites]
Clin Cancer Res. 2005 May 15;11(10):3714-21
[
15897568.001
]
[Cites]
N Engl J Med. 2005 Nov 10;353(19):2012-24
[
16282176.001
]
[Cites]
J Clin Oncol. 2006 Jan 10;24(2):217-27
[
16365183.001
]