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1. He M, Aisner S, Benevenia J, Patterson F, Harrison LE, Hameed M: Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma. Pathol Res Pract; 2009;205(6):386-94
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  • [Title] Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma.
  • The atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive subtype of liposarcoma unless dedifferentiation occurs.
  • The aim of this study is to study the role of p16INK4a gene promoter methylation and p16 expression in tumor progression (dedifferentiation) and recurrence of ALT/WDLPS.
  • Four cases of dedifferentiated liposarcomas (DDLPS) and three cases of recurrent well-differentiated liposarcomas (WDLPS) were collected, and methylation status of p16INK4a gene promoter was analyzed using methylation-specific PCR (MSP) on DNA extracted from paraffin blocks. p16 expression was examined by immunohistochemistry on the same blocks.
  • Methylation of p16INK4a gene promoter was seen in the dedifferentiated (DD) components only, in two out of four (2/4, 50%) DDLPS.
  • [MeSH-major] Cell Dedifferentiation / genetics. Epigenesis, Genetic. Genes, p16. Liposarcoma / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 19186005.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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2. Raney B, Anderson J, Arndt C, Crist W, Maurer H, Qualman S, Wharam M, Wiener E, Meyer W, Soft-Tissue Sarcoma Committee of The Children's Oncology Group, Arcadia, CA: Primary renal sarcomas in the Intergroup Rhabdomyosarcoma Study Group (IRSG) experience, 1972-2005: A report from the Children's Oncology Group. Pediatr Blood Cancer; 2008 Sep;51(3):339-43
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  • Anaplasia was present in six (60%) of the tumors.
  • At diagnosis, seven patients had localized disease: four underwent complete removal of tumor (Group I), two had microscopic residual (Group II), and one had gross residual tumor (Group III).
  • The six Group I and II patients survive, continuously disease-free, at 2.7-17.3 years (median, 4.7 years).
  • CONCLUSIONS: Patients with renal sarcomas often present with large tumors, many of them containing anaplastic features.
  • Removing all gross disease at diagnosis, if feasible, is a critical component of treatment to curing patients with renal sarcoma.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18523987.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA072989; United States / NCI NIH HHS / CA / U10 CA029511; None / None / / U10 CA024507-24; United States / NCI NIH HHS / CA / CA-24507; United States / NCI NIH HHS / CA / CA-72989; United States / NCI NIH HHS / CA / U10 CA024507-24; United States / NCI NIH HHS / CA / U10 CA098543; United States / NCI NIH HHS / CA / U10 CA098543-01; United States / NCI NIH HHS / CA / CA-29511; United States / NCI NIH HHS / CA / U10 CA024507
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS123699; NLM/ PMC2803057
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3. Kambe Y, Takeda Y, Yamamoto K, Kojima K, Tamada Y, Tomita N: Effect of RGDS-expressing fibroin dose on initial adhesive force of a single chondrocyte. Biomed Mater Eng; 2010;20(6):309-16
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  • Previously, we showed that chondrocytes cultured in/on silk fibroin scaffolds proliferate without dedifferentiating into fibroblast-like cells and that RGDS sequences genetically interfused in the fibroin light chain protein enhance cartilage tissue formation.

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  • (PMID = 21263177.001).
  • [ISSN] 1878-3619
  • [Journal-full-title] Bio-medical materials and engineering
  • [ISO-abbreviation] Biomed Mater Eng
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible; 0 / Oligopeptides; 9007-76-5 / Fibroins; 91037-65-9 / arginyl-glycyl-aspartyl-serine
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4. Azueta A, Gatius S, Matias-Guiu X: Endometrioid carcinoma of the endometrium: pathologic and molecular features. Semin Diagn Pathol; 2010 Nov;27(4):226-40
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  • Several subtypes have been described, including the presence of squamous differentiation, villoglandular pattern, secretory features and ciliated cells.
  • Recently recognized subtypes are the tumors that arise in the setting of hereditary nonpolyposis colon cancer syndrome, tumors with small nonvillous papillae, presence of microglandular pattern, sertoliform features, and dedifferentiated carcinomas.

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  • (PMID = 21309258.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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5. Ito Y, Miyauchi A: Prognostic factors and therapeutic strategies for differentiated carcinomas of the thyroid. Endocr J; 2009;56(2):177-92
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  • [Title] Prognostic factors and therapeutic strategies for differentiated carcinomas of the thyroid.
  • Differentiated thyroid carcinoma originates from thyroid follicular cells and is the most prominent malignancy of the endocrine organs.
  • There are two histological types of differentiated carcinoma, namely, papillary and follicular carcinoma.
  • Generally, these carcinomas show an indolent character, but when the lesion dedifferentiates and becomes undifferentiated carcinoma, it displays very rapid growth with an adverse prognosis and is regarded even as the most aggressive malignancy among human solid carcinomas.

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  • (PMID = 18703852.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 113
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6. Parameswaran R, Brooks S, Sadler GP: Molecular pathogenesis of follicular cell derived thyroid cancers. Int J Surg; 2010;8(3):186-93
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  • This results in the formation of differentiated thyroid cancers like the papillary, follicular or Hurthle cell cancers.
  • Anaplastic carcinoma may develop from papillary or follicular carcinoma by dedifferentiation.


7. Pita JM, Banito A, Cavaco BM, Leite V: Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas. Br J Cancer; 2009 Nov 17;101(10):1782-91
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  • [Title] Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas.
  • BACKGROUND: Poorly differentiated thyroid carcinomas (PDTC) represent a heterogeneous, aggressive entity, presenting features that suggest a progression from well-differentiated carcinomas.
  • Poorly differentiated thyroid carcinomas presented molecular signatures related to cell proliferation, poor prognosis, spindle assembly checkpoint and cell adhesion.
  • Compared with normal tissues, PTC had 307 out of 494 (60%) genes over-expressed, FTC had 137 out of 171 (80%) genes under-expressed, whereas PDTC had 92 out of 107 (86%) genes under-expressed, suggesting that gene downregulation is involved in tumour dedifferentiation.
  • [MeSH-minor] Adolescent. Adult. Cell Adhesion / physiology. Cell Growth Processes / physiology. Disease Progression. Female. Gene Expression Profiling. Humans. Male. Middle Aged. Protein Array Analysis. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Young Adult

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  • (PMID = 19809427.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2778548
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8. Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC: Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol; 2009;9:26
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  • [Title] Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors.
  • The majority of the precursor cells lacking Apc failed to differentiate into chondrocytes or osteoblasts.
  • Inactivation of Apc in chondrocytes was associated with dedifferentiation of these cells.
  • CONCLUSION: Our data indicate that a tight Apc-mediated control of beta-catenin levels is essential for differentiation of skeletal precursors as well as for the maintenance of a chondrocytic phenotype in a spatio-temporal regulated manner.
  • [MeSH-minor] Animals. Cell Differentiation / genetics. Chondrocytes / cytology. Chondrocytes / metabolism. Chondrogenesis / genetics. Collagen Type II / genetics. Gene Expression Regulation, Developmental. In Situ Hybridization. Mice. Mice, Knockout. Mice, Transgenic. Osteoblasts / cytology. Osteoblasts / metabolism. Osteogenesis / genetics. Phenotype. Time Factors

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  • (PMID = 19356224.001).
  • [ISSN] 1471-213X
  • [Journal-full-title] BMC developmental biology
  • [ISO-abbreviation] BMC Dev. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Col2a1 protein, mouse; 0 / Collagen Type II; 0 / beta Catenin
  • [Other-IDs] NLM/ PMC2678105
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9. Hines J: Small molecules driving myotube fission. Chem Biol; 2005 Oct;12(10):1058-60
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  • They convincingly demonstrate that cellularization remains integral to myogenic dedifferentiation, but is insufficient for reentry of the mononucleate progeny into the cell cycle.
  • [MeSH-major] Cell Cycle. Cell Differentiation. Muscle Fibers, Skeletal / cytology. Muscle Fibers, Skeletal / metabolism

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  • [CommentOn] Chem Biol. 2005 Oct;12(10):1117-26 [16242654.001]
  • (PMID = 16242647.001).
  • [ISSN] 1074-5521
  • [Journal-full-title] Chemistry & biology
  • [ISO-abbreviation] Chem. Biol.
  • [Language] eng
  • [Publication-type] Comment; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ciliary Neurotrophic Factor; 0 / Morpholines; 0 / Purines; 0 / myoseverin; Z499CLJ023 / 2-(4-morpholinoanilino)-6-cyclohexylaminopurine
  • [Number-of-references] 16
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10. Pallet N, Bouvier N, Bendjallabah A, Rabant M, Flinois JP, Hertig A, Legendre C, Beaune P, Thervet E, Anglicheau D: Cyclosporine-induced endoplasmic reticulum stress triggers tubular phenotypic changes and death. Am J Transplant; 2008 Nov;8(11):2283-96
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  • The aim of the present study was to characterize the features of tubular ER stress induced by cyclosporine and to investigate its effects on cell differentiation and viability.
  • Thus, we describe a novel mechanism that initiates dedifferentiation and tubular cell death upon cyclosporine treatment.
  • [MeSH-minor] Animals. Cell Differentiation. Cell Survival. Cinnamates / pharmacology. Cyclophilin A / metabolism. Humans. Male. Phenotype. Rats. Rats, Sprague-Dawley. Thiourea / analogs & derivatives. Thiourea / pharmacology. Transforming Growth Factor beta / metabolism

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  • (PMID = 18785955.001).
  • [ISSN] 1600-6143
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cinnamates; 0 / Immunosuppressive Agents; 0 / Transforming Growth Factor beta; 0 / salubrinal; 83HN0GTJ6D / Cyclosporine; EC 5.2.1.- / Cyclophilin A; GYV9AM2QAG / Thiourea
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11. Kawano N, Inayama Y, Nakaigawa N, Yao M, Ogawa T, Aoki I, Kitamura H, Nakatani Y, Nagashima Y: Composite distal nephron-derived renal cell carcinoma with chromophobe and collecting duct carcinomatous elements. Pathol Int; 2005 Jun;55(6):360-5
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  • Histologically, the tumor was composed of chromophobe elements with dedifferentiation, and CDC elements.


12. Chen XW, Jiang P, Gao JH, Liao YJ, Han Z: [Experimental study of human adipocyte dedifferentiation for adipose tissue engineering]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Apr;29(4):606-10
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  • [Title] [Experimental study of human adipocyte dedifferentiation for adipose tissue engineering].
  • OBJECTIVE: To investigate the dedifferentiation of mature adipocytes and the possibility of adipose tissue engineering using dedifferentiated adipocytes.
  • The cells were cultured in adipogenic, chondrogenic or osteogenic media, and Oil red-O staining, Alcian blue staining and Alizarin red staining were used for dedifferentiation identification.
  • After ceiling adherent culture, the adipocytes underwent morphological changes into fibroblast-like cells indicating their dedifferentiation.
  • The dedifferentiated adipocytes were induced for adipogenic, chondrogenic and osteogenic differentiation in specified media.
  • CONCLUSION: Mature adipocytes can dedifferentiate in vitro culture, and the dedifferentiated adipocytes are capable of differentiating into adipogenic, chondrogenic and osteogenic lineages.
  • Adipose tissue engineering can be achieved in vivo using the dedifferentiated adipocytes as the seed cells.
  • [MeSH-major] Adipocytes / cytology. Cell Dedifferentiation. Tissue Engineering / methods

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  • (PMID = 19403375.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Chou WC, Hung YS, Lu CH, Yeh KY, Sheu S, Liaw CC: De novo dedifferentiated chordoma of the sacrum: a case report and review of the literature. Chang Gung Med J; 2009 May-Jun;32(3):330-5
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  • [Title] De novo dedifferentiated chordoma of the sacrum: a case report and review of the literature.
  • Dedifferentiated chordoma is a rare primary malignant bone cancer.
  • Most cases of dedifferentiated chordoma (DC) are transformed from recurrent chordoma after surgical resection or radiation.
  • We report a case of de novo DC of the sacrum in a patient without prior surgical procedure or radiation treatment.

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  • (PMID = 19527613.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China (Republic : 1949- )
  • [Number-of-references] 20
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14. Parham DM, Qualman SJ, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, Meyer WH, Soft Tissue Sarcoma Committee of the Children's Oncology Group: Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Am J Surg Pathol; 2007 Jun;31(6):895-901
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  • The possibility of morphologic variation among these molecular subtypes has not been investigated.
  • We evaluated cytohistologic parameters such as microcyst formation, solid foci, differentiation, giant cell formation, anaplasia, nuclear grade, mitosis/karyorrhexis index, rosette formation, geographic necrosis, presence and amount of rhabdomyoblastic differentiation, and the presence of foci resembling embryonal rhabdomyosarcoma.

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  • (PMID = 17527077.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 98543; United States / NCI NIH HHS / CA / CA24507; United States / NCI NIH HHS / CA / CA72989; United States / NCI NIH HHS / CA / CA81659; United States / NCI NIH HHS / CA / CA89461; United States / NCI NIH HHS / CA / CA98413; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FOXO1 protein, human; 0 / Forkhead Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / PAX3 protein, human; 0 / PAX7 Transcription Factor; 0 / PAX7 protein, human; 0 / Paired Box Transcription Factors
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15. Hasegawa A, Hisatomi O, Yamamoto S, Ono E, Tokunaga F: Stathmin expression during newt retina regeneration. Exp Eye Res; 2007 Oct;85(4):518-27
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  • Moreover, stathmin may function in the dedifferentiating process of retinal pigment epithelium cells.

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  • (PMID = 17707372.001).
  • [ISSN] 0014-4835
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Eye Proteins; 0 / RNA, Messenger; 0 / Stathmin
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16. Villar-Suárez V, Colaço B, Calles-Venal I, Bravo IG, Fernández-Alvarez JG, Fernández-Caso M, Villar-Lacilla JM: Effects of extracellular matrix on the morphology and behaviour of rabbit auricular chondrocytes in culture. J Biomed Biotechnol; 2005;2005(4):364-73
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  • Isolated chondrocytes dedifferentiate to a fibroblast-like shape on plastic substrata and proliferate extensively, but rarely form nodules.
  • In an attempt to reproduce this stable chondrogenic state, we added a cartilage protein extract, a sugar extract, and hyaluronan to the medium of previously dedifferentiated chondrocytes.
  • Protein extract has positive effects on the differentiation of previously proliferated chondrocytes and permits nodule formation and the extensive production of type-II collagen.

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  • [ISSN] 1110-7243
  • [Journal-full-title] Journal of biomedicine & biotechnology
  • [ISO-abbreviation] J. Biomed. Biotechnol.
  • [Language] eng
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17. Bui Nguyen Binh M, Collin F, Coindre JM: [Soft tissue sarcomas: update on molecular data]. Cancer Radiother; 2006 Feb-Mar;10(1-2):15-21
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  • Detection of MDM2 and CDK4 genes amplifications (FISH or quantitative PCR) may be sometimes useful in well differentiated and dedifferentiated liposarcomas diagnosis.

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  • (PMID = 16442827.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 35
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18. Brandl A, Angele P, Roll C, Prantl L, Kujat R, Kinner B: Influence of the growth factors PDGF-BB, TGF-beta1 and bFGF on the replicative aging of human articular chondrocytes during in vitro expansion. J Orthop Res; 2010 Mar;28(3):354-60
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  • Decreasing replicative potential and dedifferentiation of articular chondrocytes during expansion in cell culture are essential limitations for tissue engineering and cell therapy approaches.

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  • (PMID = 19798738.001).
  • [ISSN] 1554-527X
  • [Journal-full-title] Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • [ISO-abbreviation] J. Orthop. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1; 0 / platelet-derived growth factor BB; 103107-01-3 / Fibroblast Growth Factor 2; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases; EC 2.7.7.49 / Telomerase
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19. Cheng J, Türkel N, Hemati N, Fuller MT, Hunt AJ, Yamashita YM: Centrosome misorientation reduces stem cell division during ageing. Nature; 2008 Dec 4;456(7222):599-604
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  • Asymmetric division of adult stem cells generates one self-renewing stem cell and one differentiating cell, thereby maintaining tissue homeostasis.
  • We also show that some of the misoriented GSCs probably originate from dedifferentiation of spermatogonia.

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  • (PMID = 18923395.001).
  • [ISSN] 1476-4687
  • [Journal-full-title] Nature
  • [ISO-abbreviation] Nature
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P01 DK053074-060004; United States / NIDDK NIH HHS / DK / P01 DK053074; United States / NIDDK NIH HHS / DK / P01 DK53074; United States / NIGMS NIH HHS / GM / R01 GM072006-05; United States / NIGMS NIH HHS / GM / R01 GM086481; United States / NIDDK NIH HHS / DK / DK053074-060004; United States / NIGMS NIH HHS / GM / R01 GM080501; United States / NIGMS NIH HHS / GM / R01 GM072006; United States / NIGMS NIH HHS / GM / GM080501-02; United States / NIGMS NIH HHS / GM / R01 GM086481-01; United States / NIGMS NIH HHS / GM / R01GM072006; United States / NIGMS NIH HHS / GM / R01 GM080501-01; United States / NIGMS NIH HHS / GM / R01 GM080501-02; United States / NIGMS NIH HHS / GM / GM080501-01; United States / NIGMS NIH HHS / GM / GM072006-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS107078; NLM/ PMC2712891
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20. Cedervall J, Jamil S, Prasmickaite L, Cheng Y, Eskandarpour M, Hansson J, Maelandsmo GM, Ringborg U, Gulyas M, Zhen HS, Kanter L, Ahrlund-Richter L: Species-specific in vivo engraftment of the human BL melanoma cell line results in an invasive dedifferentiated phenotype not present in xenografts. Cancer Res; 2009 May 1;69(9):3746-54
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  • [Title] Species-specific in vivo engraftment of the human BL melanoma cell line results in an invasive dedifferentiated phenotype not present in xenografts.
  • This BL population had a desmoplastic spindle-like appearance, with markers indicative of dedifferentiation and migration.
  • In conclusion, these data provide exciting options for using the hEST model in molecular in vivo studies on differentiation, invasiveness, and malignancy of human melanoma, while analyzing species-specific reactions in vivo.
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Cell Line, Tumor. Embryonal Carcinoma Stem Cells / pathology. Embryonic Stem Cells / pathology. Humans. Immunohistochemistry. Male. Mice. Mice, SCID. Phenotype. S100 Proteins / biosynthesis. Species Specificity. Teratoma / metabolism. Teratoma / pathology


21. Svajdler M, Bohus P, Rychlý B, Sulla I, Moram M: [Post-radiation dedifferentiation of meningioma into chondroblastic osteosarcoma]. Cesk Patol; 2009 Jan;45(1):20-3
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  • [Title] [Post-radiation dedifferentiation of meningioma into chondroblastic osteosarcoma].
  • We report a case of post-radiation dedifferentiation of meningothelial meningioma into chondroblastic osteosarcoma.
  • To our knowledge, this case represents only the second reported case of post-radiation dedifferentiation of meningioma into osteosarcoma.


22. Buitrago W, Roop DR: Oct-4: the almighty POUripotent regulator? J Invest Dermatol; 2007 Feb;127(2):260-2
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  • Grinnell et al. demonstrate for the first time that Oct-4 by itself has the ability to reprogram committed somatic cells, inducing their dedifferentiation by reverting them to a more developmentally potent state.
  • [MeSH-major] Cell Differentiation / physiology. Octamer Transcription Factor-3 / physiology. Pluripotent Stem Cells / physiology

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  • [CommentOn] J Invest Dermatol. 2007 Feb;127(2):372-80 [16932739.001]
  • (PMID = 17228302.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Comment; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Octamer Transcription Factor-3
  • [Number-of-references] 16
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23. Russell MJ, Flynt FL, Harroff AL, Fadare O: Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and beta-Human Chorionic Gonadotropin Production. Sarcoma; 2008;2008:658090
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  • [Title] Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and beta-Human Chorionic Gonadotropin Production.
  • Dedifferentiated liposarcomas may display a variety of "heterologous" lines of differentiation, including osseous, vascular, skeletal, and/or smooth muscular.
  • This report describes the first example of a dedifferentiated liposarcoma that combined both of the aforementioned features: extensive heterologous (leiomyosarcomatous) differentiation and beta-hCG production (maximum serum levels 1046 mIU/ml, reference <5 mIU/ml).
  • In addition to characteristic morphologic features, lipogenic and smooth muscle differentiation were confirmed with immunohistochemical stains for MDM2 and smooth muscle actin, respectively.

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  • (PMID = 18382626.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2276869
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24. Walter MA, Wild D, Rasch H, Müller-Brand J, Müller B, Bilz S: Coregistered iodine-131 single photon emission computed tomography/computed tomography reveals dedifferentiation in a metastatic follicular thyroid carcinoma. Thyroid; 2006 Oct;16(10):1063-4
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  • [Title] Coregistered iodine-131 single photon emission computed tomography/computed tomography reveals dedifferentiation in a metastatic follicular thyroid carcinoma.

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  • (PMID = 17042695.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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25. Brovkina AF, Tadzhieva ZA, Sherstnev VV: [Clinical and epidemiological study of lacrimal neoplasms]. Vestn Oftalmol; 2009 May-Jun;125(3):3-8
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  • With the higher grade of anaplasia, the likelihood of a recurrence of a tumor and the rate of its growth increased (r = +0.83).

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  • (PMID = 19566038.001).
  • [ISSN] 0042-465X
  • [Journal-full-title] Vestnik oftalmologii
  • [ISO-abbreviation] Vestn Oftalmol
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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26. Lobakova ES, Smirnov IA: [Experimental lichenology]. Zh Obshch Biol; 2008 Sep-Oct;69(5):364-78
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  • Cultural methods involve development of dedifferentiated cell aggregates of lichen thallus ("lichen tissue cultures") on the solid and liquid media.

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  • (PMID = 18956574.001).
  • [ISSN] 0044-4596
  • [Journal-full-title] Zhurnal obshcheĭ biologii
  • [ISO-abbreviation] Zh. Obshch. Biol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biological Products; 0 / Culture Media
  • [Number-of-references] 51
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27. van der Windt AE, Jahr H, Farrell E, Verhaar JA, Weinans H, van Osch GJ: Calcineurin inhibitors promote chondrogenic marker expression of dedifferentiated human adult chondrocytes via stimulation of endogenous TGFbeta1 production. Tissue Eng Part A; 2010 Jan;16(1):1-10
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  • [Title] Calcineurin inhibitors promote chondrogenic marker expression of dedifferentiated human adult chondrocytes via stimulation of endogenous TGFbeta1 production.
  • During expansion, loss of chondrogenic phenotype takes place (dedifferentiation).
  • Cn activity in human articular chondrocytes was significantly increased during dedifferentiation and decreased during redifferentiation in vitro.
  • [MeSH-major] Antigens, Differentiation / biosynthesis. Calcineurin Inhibitors. Cartilage, Articular / metabolism. Cell Dedifferentiation / drug effects. Chondrocytes / metabolism. Gene Expression Regulation / drug effects. Immunosuppressive Agents / pharmacology. Tacrolimus / pharmacology. Transforming Growth Factor beta1 / biosynthesis

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  • (PMID = 19604038.001).
  • [ISSN] 1937-335X
  • [Journal-full-title] Tissue engineering. Part A
  • [ISO-abbreviation] Tissue Eng Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Differentiation; 0 / Calcineurin Inhibitors; 0 / Immunosuppressive Agents; 0 / Transforming Growth Factor beta1; EC 3.1.3.16 / Calcineurin; WM0HAQ4WNM / Tacrolimus
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28. Inoue K, Higaki Y, Yoshida H: Giant retroperitoneal liposarcoma. Int J Urol; 2005 Feb;12(2):220-2
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  • We report a case with an extremely large dedifferentiated liposarcoma that weighed 18 kg.

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  • (PMID = 15733122.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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29. Fernández-Ruiz M, Rodríguez-Gil Y, Guerra-Vales JM, Manrique-Municio A, Moreno-González E, Colina-Ruizdelgado F: Primary retroperitoneal liposarcoma: clinical and histological analysis of ten cases. Gastroenterol Hepatol; 2010 May;33(5):370-6
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  • Histological analysis revealed the following subtypes: well-differentiated (6 cases), dedifferentiated (two cases), pleomorphic, and myxoid/round cell (one case each).
  • [MeSH-minor] Abdominal Neoplasms / mortality. Abdominal Neoplasms / secondary. Aged. Aged, 80 and over. Breast Neoplasms. Disease-Free Survival. Female. Humans. Incidental Findings. Kaplan-Meier Estimate. Liposarcoma, Myxoid / diagnosis. Liposarcoma, Myxoid / pathology. Liposarcoma, Myxoid / surgery. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasms, Multiple Primary. Retrospective Studies. Spain / epidemiology

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  • (PMID = 20206410.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Spain
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30. Chia SH, Homicz MR, Schumacher BL, Thonar EJ, Masuda K, Sah RL, Watson D: Characterization of human nasal septal chondrocytes cultured in alginate. J Am Coll Surg; 2005 May;200(5):691-704
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  • BACKGROUND: After serial passages in monolayer, chondrocytes dedifferentiate into a fibroblast-like phenotype.
  • Our objective was to determine if culture in alginate affects the phenotype of dedifferentiated human nasal septal chondrocytes.
  • [MeSH-minor] Analysis of Variance. Cell Differentiation. Cells, Cultured. Collagen / metabolism. DNA / metabolism. Glycosaminoglycans / metabolism. Humans. Immunoenzyme Techniques. Time Factors

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  • (PMID = 15848359.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG04736; United States / NIA NIH HHS / AG / AG07996; United States / NIAMS NIH HHS / AR / AR39239; United States / NIAMS NIH HHS / AR / AR44058; United States / NIAMS NIH HHS / AR / AR46555; United States / NIAMS NIH HHS / AR / AR48152
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alginates; 0 / Glycosaminoglycans; 9007-34-5 / Collagen; 9007-49-2 / DNA
  • [Keywords] NASA ; NASA Discipline Cell Biotechnology / Non-NASA Center
  • [Investigator] Sah RL
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31. Hayashi K, Nakamura S, Nishida W, Sobue K: Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription. Mol Cell Biol; 2006 Dec;26(24):9456-70
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  • During the onset and progression of atherosclerosis, the vascular smooth muscle cell (VSMC) phenotype changes from differentiated to dedifferentiated, and in some cases, this change is accompanied by osteogenic transition, resulting in vascular calcification.
  • One characteristic of dedifferentiated VSMCs is the down-regulation of smooth muscle cell (SMC) marker gene expression.
  • In this study, we found that the BMP2-, BMP4-, and BMP6-induced expression of Msx transcription factors (Msx1 and Msx2) preceded the down-regulation of SMC marker expression in cultured differentiated VSMCs.

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  • (PMID = 17030628.001).
  • [ISSN] 0270-7306
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Morphogenetic Proteins; 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / Homeodomain Proteins; 0 / MSX1 Transcription Factor; 0 / MSX2 protein; 0 / Msx1 protein, rat; 0 / Nuclear Proteins; 0 / Serum Response Factor; 0 / Trans-Activators; 0 / myocardin
  • [Other-IDs] NLM/ PMC1698541
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32. Lugli A, Zlobec I, Minoo P, Baker K, Tornillo L, Terracciano L, Jass JR: Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer-a tissue microarray-based approach. Hum Pathol; 2006 Aug;37(8):1022-31
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  • Tumor budding is defined as dedifferentiated cancer cells at the invasive margin of colorectal cancer (CRC) and correlates with a worse prognosis.

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  • (PMID = 16867865.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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33. Paternot S, Arsenijevic T, Coulonval K, Bockstaele L, Dumont JE, Roger PP: Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin D1 or cyclin D3: differential involvement in the distinct mitogenic modes of thyroid epithelial cells. Cell Cycle; 2006 Jan;5(1):61-70
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  • The differentiation-associated mitogenic stimulation by TSH and cAMP specifically requires the assembly and activation of cyclin D3-cyclin-dependent kinase (CDK)4 associated to p27(kip1), while the dedifferentiating proliferation induced by growth factors is associated with induction of cyclin D1.
  • Therefore, different D-type cyclins could differently impact some pRb functions, which should be considered not only in the understanding of the relationships between cell cycle and differentiation expression in the distinct mitogenic modes of thyroid cells, but also in various development or differentiation models associated with dramatic switches in the expression of individual D-type cyclins.

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  • (PMID = 16294008.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCND3 protein, human; 0 / Cyclin D3; 0 / Cyclins; 0 / Retinoblastoma Protein; 136601-57-5 / Cyclin D1; EC 2.7.11.22 / Cyclin-Dependent Kinase 4
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34. D'Angelo E, Spagnoli LG, Prat J: Comparative clinicopathologic and immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization classification system. Hum Pathol; 2009 Nov;40(11):1571-85
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  • A tissue microarray was prepared and immunostaining performed for 10 selected oncoproteins involved in cell proliferation (Ki-67, P53, p16, and phosphatase and tensin homolog [PTEN]), cell differentiation (CD10, h-caldesmon, estrogen receptor, and progesterone receptor), and apoptosis (bcl-2 and Twist).
  • A subset of undifferentiated endometrial sarcomas composed of cells with uniform nuclei may be a separate entity from those with nuclear anaplasia and may be related to low-grade endometrial stromal sarcomas.


35. Sinescu I, Hârza M, Serbănescu B, Gîngu C, Stefan B, Dudu C: Renal transplant in a child with bilateral Wilms' tumor national premiere. J Med Life; 2008 Jan-Mar;1(1):30-3
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  • 30.04-19.11.2001--polychemotherapy according to the NWTS-5 stages 2-4 focal anaplasia and radiotherapy of the right kidney bed (29.06.2001).


36. Kim YJ, Ketter R, Henn W, Zang KD, Steudel WI, Feiden W: Histopathologic indicators of recurrence in meningiomas: correlation with clinical and genetic parameters. Virchows Arch; 2006 Nov;449(5):529-38
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  • Independent predictors of recurrence included (1) anaplasia;.

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  • (PMID = 17016718.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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37. Fan GG, Deng QL, Wu ZH, Guo QY: Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: a valuable tool to predict tumour grading? Br J Radiol; 2006 Aug;79(944):652-8
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  • 14 low-grade gliomas (WHO Grade I and II) and 8 anaplastic gliomas were verified histologically.
  • The results showed that lower ADC values were present in the solid portions of anaplastic gliomas, but not in low grade (p < 0.01).
  • However, there was no significant difference between anaplastic gliomas and low-grade gliomas.
  • Meanwhile, higher rCBV ratios were present in both solid portions and peritumoural regions of anaplastic gliomas, but not in low grade gliomas (p < 0.01).
  • In conclusion, non-enhancing brain gliomas with lower ADC values in the solid portions and higher rCBV ratios in both solid portions and peritumoural regions of tumours are significantly correlated with anaplasia.

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  • (PMID = 16641420.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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38. Vajtai I, Kappeler A, Lukes A, Arnold M, Lüthy AR, Leibundgut K: Papillary glioneuronal tumor. Pathol Res Pract; 2006;202(2):107-12
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  • The descriptive term papillary glioneuronal tumor (PGNT) has been repeatedly applied to a morphologic subset of low-grade mixed glial-neuronal neoplasia of juvenile and young adult patients.
  • Focally, the latter imprinted a pseudopapillary aspect on this otherwise solid lesion.
  • Signs of anaplasia, in particular mitotic figures, endothelial proliferation, or necrosis were consistently lacking.

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  • (PMID = 16413693.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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39. Evans HL: Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol; 2007 Jan;31(1):1-14
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  • The cases were divided into 4 groups based on the findings in the initial excision specimen: conventional atypical lipomatous tumor (n=15), cellular atypical lipomatous tumor (n=21), dedifferentiated liposarcoma (n=24), and atypical lipomatous tumor with a pleomorphic liposarcoma-like component (n=1).
  • The term "cellular atypical lipomatous tumor" was applied to atypical lipomatous tumors having areas of increased cellularity that when non-lipogenic lacked the 5 mitotic figures per 10 high-power fields (maximal rate) required for a dedifferentiated component and when lipogenic fell short of being truly pleomorphic liposarcoma-like.
  • Among the 49 patients with neoplasms of central body sites (mostly retroperitoneum), those with dedifferentiated liposarcoma had significantly shorter survival (median 77 mo) than those with cellular (median 142 mo) or conventional (median 209 mo) atypical lipomatous tumor, whereas there was no statistically significant difference between the latter 2 categories.
  • Patients with atypical lipomatous tumor (either cellular or conventional) in central body sites had significantly shorter survival if the tumor transformed into dedifferentiated liposarcoma in recurrence, and, conversely, those with central body site dedifferentiated liposarcoma had significantly longer survival if it recurred as atypical lipomatous tumor.
  • Metastasis (7 cases) occurred only when the initial specimen or a recurrence demonstrated dedifferentiated liposarcoma.

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  • (PMID = 17197914.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Jahan I, Fujimoto J, Alam SM, Sato E, Sakaguchi H, Tamaya T: Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers. Oncol Rep; 2007 Feb;17(2):345-50
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  • PAR-2 histoscores and mRNA levels both significantly increased in uterine endometrial cancers with clinical stages (I<II<III, p<0.001), dedifferentiation (G1<G2<G3, p<0.001) and myometrial invasion (A<B, p<0.001; B<C, p<0.05) in comparison to normal endometria.
  • PAR-2 was upregulated during uterine endometrial cancer progression with dedifferentiation and myometrial invasion.
  • [MeSH-minor] Adult. Aged. Antigens, CD31 / biosynthesis. Disease Progression. Endometrium / metabolism. Endometrium / pathology. Female. Humans. Immunohistochemistry. Middle Aged. RNA, Messenger / metabolism

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  • (PMID = 17203172.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / RNA, Messenger; 0 / Receptor, PAR-2
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41. Zaglia T, Dedja A, Candiotto C, Cozzi E, Schiaffino S, Ausoni S: Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes. J Mol Cell Cardiol; 2009 May;46(5):653-62
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  • [Title] Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes.
  • Interstitial cells of the adult rat heart were characterized with respect to i) expression of cardiac markers of commitment and differentiation, ii) myogenic potential in vitro and iii) ability to modulate cardiomyocyte differentiation state.
  • However, cardiac fibroblasts, but not skin fibroblasts, stimulate dedifferentiation of adult cardiomyocytes and their re-entry into the cell cycle in vitro, as demonstrated by the high number of cardiomyocytes expressing Ki67, phosphorylated histone H3 (H3P) and incorporating 5-bromodeoxiuridine (BrdU) in the co-cultures.
  • In conclusion, cardiac fibroblasts have peculiar expression of myogenic transcription factors, a property that may have an impact for reprogramming these cells to the myogenic differentiation.
  • In addition, they are able to modulate the behavior of adult cardiomyocytes, a property that may be used to promote dedifferentiation and proliferation of cardiac cells in the damaged myocardium.
  • [MeSH-major] Cell Cycle. Cell Dedifferentiation. GATA4 Transcription Factor / metabolism. Myocytes, Cardiac / cytology. Myocytes, Cardiac / metabolism
  • [MeSH-minor] Animals. Animals, Newborn. Cell Differentiation. Cells, Cultured. Fibroblasts / cytology. Fibroblasts / metabolism. Myocardium / cytology. Myocardium / metabolism. Pericytes / cytology. Pericytes / metabolism. Rats. Rats, Sprague-Dawley

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  • (PMID = 19162035.001).
  • [ISSN] 1095-8584
  • [Journal-full-title] Journal of molecular and cellular cardiology
  • [ISO-abbreviation] J. Mol. Cell. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GATA4 Transcription Factor; 0 / Gata4 protein, rat
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42. Kumar AJ, Leeds NE, Kumar VA, Fuller GN, Lang FF, Milas Z, Weinberg JS, Ater JL, Sawaya R: Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. J Comput Assist Tomogr; 2010 Jul;34(4):601-11
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  • Despite the aggressive imaging appearance of PA, there is no histopathologic evidence of anaplasia.

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  • (PMID = 20657231.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Vandewalle C, Comijn J, De Craene B, Vermassen P, Bruyneel E, Andersen H, Tulchinsky E, Van Roy F, Berx G: SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res; 2005;33(20):6566-78
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  • Here, we show that expression of SIP1 in human epithelial cells results in a clear morphological change from an epithelial to a mesenchymal phenotype.
  • Induction of this epithelial dedifferentiation was accompanied by repression of several cell junctional proteins, with concomitant repression of their mRNA levels.
  • These data indicate that, during epithelial dedifferentiation, SIP1 represses in a coordinated manner the transcription of genes coding for junctional proteins contributing to the dedifferentiated state; this repression occurs by a general mechanism mediated by Smad Interacting Protein 1 (SIP1)-binding sites.

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  • (PMID = 16314317.001).
  • [ISSN] 1362-4962
  • [Journal-full-title] Nucleic acids research
  • [ISO-abbreviation] Nucleic Acids Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins; 0 / Chromatin; 0 / Connexins; 0 / Homeodomain Proteins; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Repressor Proteins
  • [Other-IDs] NLM/ PMC1298926
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44. Patel RM, Folpe AL: Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours. Pathology; 2009;41(6):527-32
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  • Restriction of hTERT expression to high grade lesions, and its absence in low grade sarcomas (including the well-differentiated component of dedifferentiated liposarcoma), suggests that telomerase activation is a late event in sarcoma progression.

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  • (PMID = 19900100.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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45. Kim HS, Lee J, Yi SY, Jun HJ, Choi YL, Ahn GH, Seo SW, Lim DH, Ahn YC, Park JO, Kim SJ: Liposarcoma: exploration of clinical prognostic factors for risk based stratification of therapy. BMC Cancer; 2009;9:205
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  • RESULTS: Fifty patients (53.2%) presented with well differentiated, 22 (23.4%) myxoid, 15 (16.0%) dedifferentiated, 5 (5.3%) round cell, and 2 (2.1%) pleomorphic histology.
  • Low grade liposarcoma (well differentiated and myxoid) had a significantly prolonged OS and disease free survival (DFS) with adjuvant radiotherapy when compared with those without adjuvant radiotherapy (5-year OS, 100% vs 66.3%, P = 0.03; 1-year DFS, 92.9% vs 50.0%, respectively, P = 0.04).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Medical Oncology / methods. Middle Aged. Prognosis. Radiotherapy, Adjuvant / methods. Risk. Risk Factors. Treatment Outcome

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46. Ahmed N, Gan L, Nagy A, Zheng J, Wang C, Kandel RA: Cartilage tissue formation using redifferentiated passaged chondrocytes in vitro. Tissue Eng Part A; 2009 Mar;15(3):665-73
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  • Articular cartilage has limited ability for repair when damaged by trauma or degenerative disease, such as osteoarthritis, which can result in pain and compromised quality of life.
  • Previously, we have shown that coculture of in vitro-expanded dedifferentiated chondrocytes (P2) with small numbers of primary chondrocytes (P0) induces redifferentiation in passaged (P2) cells.
  • In this study we show that this redifferentiation is not a transient change.
  • This coculture system approach can be used to increase the number of differentiated chondrocytes that can be obtained by classical monolayer cell expansion and represents a novel way to acquire sufficient cell numbers for cartilage tissue engineering.
  • [MeSH-major] Cartilage / growth & development. Cell Differentiation. Chondrocytes / cytology
  • [MeSH-minor] Animals. Cattle. Cell Count. Cell Dedifferentiation. Cells, Cultured. Coculture Techniques. Flow Cytometry. Gene Expression Regulation. Phenotype

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  • (PMID = 18783319.001).
  • [ISSN] 1937-3341
  • [Journal-full-title] Tissue engineering. Part A
  • [ISO-abbreviation] Tissue Eng Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Sena G, Birnbaum KD: Built to rebuild: in search of organizing principles in plant regeneration. Curr Opin Genet Dev; 2010 Aug;20(4):460-5
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  • In parallel to new findings in metazoan systems, recent work in plants shows that regeneration programs commonly thought to rely on dedifferentiated cells do not need to reprogram to a ground state.

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  • (PMID = 20537526.001).
  • [ISSN] 1879-0380
  • [Journal-full-title] Current opinion in genetics & development
  • [ISO-abbreviation] Curr. Opin. Genet. Dev.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM078279-04; United States / NIGMS NIH HHS / GM / R01 GM078279; United States / NIGMS NIH HHS / GM / R01 GM078279-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS226558; NLM/ PMC2931316
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48. Bramer JA, Abudu AA, Grimer RJ, Carter SR, Tillman RM: Do pathological fractures influence survival and local recurrence rate in bony sarcomas? Eur J Cancer; 2007 Sep;43(13):1944-51
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  • In multivariate analysis, fracture remained a significant predictor of survival for osteosarcoma, but not for chondrosarcoma, where dedifferentiated subtype appeared to be decisive.

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  • (PMID = 17698347.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Kuang S, Kuroda K, Le Grand F, Rudnicki MA: Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell; 2007 Jun 1;129(5):999-1010
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  • However, whether satellite cells are stem cells, committed progenitors, or dedifferentiated myoblasts has remained unclear.
  • Prospective isolation and transplantation into muscle revealed that whereas Pax7(+)/Myf5(+) cells exhibited precocious differentiation, Pax7(+)/Myf5(-) cells extensively contributed to the satellite cell reservoir throughout the injected muscle.

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  • (PMID = 17540178.001).
  • [ISSN] 0092-8674
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR044031-11; United States / NIAMS NIH HHS / AR / R01 AR044031; United States / NIAMS NIH HHS / AR / R01 AR044031-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Luminescent Proteins; 0 / Myf5 protein, mouse; 0 / Myogenic Regulatory Factor 5; 0 / PAX7 Transcription Factor; 0 / Pax7 protein, mouse; 0 / Receptors, Notch
  • [Other-IDs] NLM/ NIHMS125932; NLM/ PMC2718740
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50. Nakamura S, Hayashi K, Iwasaki K, Fujioka T, Egusa H, Yatani H, Sobue K: Nuclear import mechanism for myocardin family members and their correlation with vascular smooth muscle cell phenotype. J Biol Chem; 2010 Nov 26;285(48):37314-23
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  • Myocardin (Mycd), which is essential for the differentiation of the smooth muscle cell lineage, is constitutively located in the nucleus, although its family members, myocardin-related transcription factors A and B (MRTF-A/B), mostly reside in the cytoplasm and translocate to the nucleus in response to Rho signaling.
  • In dedifferentiated VSMCs, the levels of importins α1 and β1 were reduced concomitant with down-regulation of Mycd, serum response factor, and smooth muscle cell markers.
  • By contrast, in differentiated VSMCs, their expressions were up-regulated.

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  • (PMID = 20847050.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Karyopherins; 0 / MKL1 protein, mouse; 0 / Nuclear Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 0 / myocardin; 0 / myocardin-related transcription factor B, mouse
  • [Other-IDs] NLM/ PMC2988337
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51. Deng X, Liu H, Huang J, Cheng L, Keller ET, Parsons SJ, Hu CD: Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression. Cancer Res; 2008 Dec 1;68(23):9663-70
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  • [Title] Ionizing radiation induces prostate cancer neuroendocrine differentiation through interplay of CREB and ATF2: implications for disease progression.
  • Here we show that fractionated ionizing radiation (IR) induces differentiation of LNCaP prostate cancer cells into neuroendocrine (NE)-like cells, which are known to be implicated in prostate cancer progression, androgen-independent growth, and poor prognosis.
  • Further analyses revealed that two cyclic AMP-responsive element binding transcription factors, cyclic AMP-response element binding protein (CREB) and activating transcription factor 2 (ATF2), function as a transcriptional activator and a repressor, respectively, of NE-like differentiation and that IR induces NE-like differentiation by increasing the nuclear content of phospho-CREB and cytoplasmic accumulation of ATF2.
  • Consistent with this notion, stable expression of a nonphosphorylatable CREB or a constitutively nuclear-localized ATF2 in LNCaP cells inhibits IR-induced NE-like differentiation.
  • IR-induced NE-like morphologies are reversible, and three IR-resistant clones isolated from dedifferentiated cells have acquired the ability to proliferate and lost the NE-like cell properties.
  • In addition, these three IR-resistant clones exhibit differential responses to IR- and androgen depletion-induced NE-like differentiation.
  • These results suggest that radiation therapy-induced NE-like differentiation may represent a novel pathway by which prostate cancer cells survive the treatment and contribute to tumor recurrence.

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  • (PMID = 19047143.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA023168-26S1; United States / NCI NIH HHS / CA / CA023168-28S1; United States / NCI NIH HHS / CA / P30 CA023168-28; United States / NCI NIH HHS / CA / P30 CA023168-26; United States / NCI NIH HHS / CA / CA023168-27S1; United States / NCI NIH HHS / CA / CA023168-27; United States / NCI NIH HHS / CA / P30 CA023168-28S1; United States / NCI NIH HHS / CA / P30 CA023168-27S1; United States / NCI NIH HHS / CA / P30 CA023168-27; United States / NCI NIH HHS / CA / P30 CA023168-25; United States / NCI NIH HHS / CA / P30 CA023168-24; United States / NCI NIH HHS / CA / CCSG CA23168; United States / NCI NIH HHS / CA / P30 CA023168
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATF2 protein, human; 0 / Activating Transcription Factor 2; 0 / CREB1 protein, human; 0 / Cyclic AMP Response Element-Binding Protein
  • [Other-IDs] NLM/ NIHMS289051; NLM/ PMC3100895
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52. Varkonyi J, Karádi I, Szocs K, Sugár I, Sápi Z, Marschalko M, Pállinger E, Darvas Z, Falus A: Loss of histidine decarboxylase as a marker of malignant transformation and dedifferentiation of B-cells infiltrating the skin. A case report of a therapy-resistant multiple myeloma complicated by skin infiltration. Acta Oncol; 2008;47(3):458-61
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  • [Title] Loss of histidine decarboxylase as a marker of malignant transformation and dedifferentiation of B-cells infiltrating the skin. A case report of a therapy-resistant multiple myeloma complicated by skin infiltration.
  • [MeSH-minor] Aged. Bone Marrow / pathology. Cell Dedifferentiation. Cell Transformation, Neoplastic. Fatal Outcome. Female. Histamine / metabolism. Humans. Plasma Cells / enzymology. Plasma Cells / pathology. Syndecan-1 / analysis

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  • (PMID = 17851872.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / SDC1 protein, human; 0 / Syndecan-1; 820484N8I3 / Histamine; EC 4.1.1.22 / Histidine Decarboxylase
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53. Hegner B, Lange M, Kusch A, Essin K, Sezer O, Schulze-Lohoff E, Luft FC, Gollasch M, Dragun D: mTOR regulates vascular smooth muscle cell differentiation from human bone marrow-derived mesenchymal progenitors. Arterioscler Thromb Vasc Biol; 2009 Feb;29(2):232-8
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  • [Title] mTOR regulates vascular smooth muscle cell differentiation from human bone marrow-derived mesenchymal progenitors.
  • We hypothesized that phosphoinositol-Akt-mammalian target of rapamycin-p70S6 kinase (PI3K/Akt/mTOR/p70S6K) pathway activation regulates VSMC differentiation from MSCs.
  • Phosphorylation of Akt and p70S6K featured downregulation of VSMC markers in dedifferentiated MSCs. mTOR inhibition with rapamycin at below pharmacological concentrations blocked p70S6K phosphorylation and induced a differentiated contractile phenotype with smooth muscle (sm)-calponin, sm-alpha-actin, and SM protein 22-alpha (SM22alpha) expression.
  • The PI3K inhibitor Ly294002 abolished Akt and p70S6K phosphorylation and reversed the dedifferentiated phenotype via induction of sm-calponin, sm-alpha-actin, SM22alpha, and myosin light chain kinase.
  • CONCLUSIONS: We describe novel pleiotropic effects of rapamycin at very low concentrations that stabilized differentiated contractile VSMCs from MSCs in addition to exerting antiproliferative and enhanced homing effects.
  • [MeSH-major] Bone Marrow Cells / metabolism. Cell Differentiation. Mesenchymal Stromal Cells / metabolism. Muscle, Smooth, Vascular / metabolism. Myocytes, Smooth Muscle / metabolism. Protein Kinases / metabolism. Signal Transduction

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  • (PMID = 19074484.001).
  • [ISSN] 1524-4636
  • [Journal-full-title] Arteriosclerosis, thrombosis, and vascular biology
  • [ISO-abbreviation] Arterioscler. Thromb. Vasc. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CXCL12 protein, human; 0 / Calcium Channels, L-Type; 0 / Chemokine CXCL12; 0 / Chromones; 0 / Morpholines; 0 / Muscle Proteins; 0 / Protein Kinase Inhibitors; 154447-36-6 / 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; EC 2.7.- / Protein Kinases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa; W36ZG6FT64 / Sirolimus
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54. Muragaki Y, Chernov M, Tajika Y, Kubo O, Iseki H, Hori T, Takakura K: Coincidence of central neurocytoma and multiple glioblastomas: a rare case report. J Neurooncol; 2009 Jul;93(3):431-5
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  • It can be speculated that both malignant neoplasms were, in fact, dedifferentiated central neurocytoma, which developed from distant tumor deposits.
  • This case seems to be in agreement with the hypothesis that central neurocytoma arises from the progenitor cells with potential for both neuronal and glial differentiation.

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  • (PMID = 19183852.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0S726V972K / Nimustine; 5J49Q6B70F / Vincristine
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55. Yearley JH, King N, Liu X, Curran EH, O'Neil SP: Biphasic malignant testicular sex cord-stromal tumor in a cotton-top tamarin (Saguinus oedipus) with review of the literature. Vet Pathol; 2008 Nov;45(6):922-7
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  • Histologic examination of the abdominal tumor showed multifocal formation of Call-Exner bodies in an otherwise highly dedifferentiated population.

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  • (PMID = 18984797.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / K01RR24120; United States / NCRR NIH HHS / RR / T32 RR007000; United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / T32 RR007000-32; United States / NCRR NIH HHS / RR / RR007000-32; United States / NCRR NIH HHS / RR / K01 RR024120
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 37
  • [Other-IDs] NLM/ NIHMS93232; NLM/ PMC2660595
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56. Maàmouri N, Cheikh I, Ouerghi H, Oukaà A, Belkahla N, Mnif E, Hechiche M, Driss M, Ben Ammar A: [Giant retroperitoneal liposarcoma. One case report]. Rev Med Interne; 2005 Feb;26(2):145-8
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  • Histological examination of the mass of the left renal lodge revealed mixed type liposarcoma (dedifferentiated and myxoid).
  • Histological examination of the retroduodenal mass and of the nodule of the coecum revealed well-differentiated liposarcoma.

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  • (PMID = 15710262.001).
  • [ISSN] 0248-8663
  • [Journal-full-title] La Revue de medecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] FRE
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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57. Adelöw C, Segura T, Hubbell JA, Frey P: The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype. Biomaterials; 2008 Jan;29(3):314-26
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  • The formation of scar tissue due to dedifferentiation of smooth muscle cells (SMCs) is one of the major issues faced when engineering bladder tissue.
  • Here we explore if human mesenchymal stem cells (MCSs), cultured in enzymatically degradable poly(ethylene glycol) (PEG) hydrogel scaffolds can be differentiated into SMC-like cells.
  • This study addresses the importance of the cellular microenvironment on cell fate, and proposes synthetic instructive biomaterials as a means to direct cell differentiation and circumvent scar tissue formation during bladder reconstruction.

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  • (PMID = 17953986.001).
  • [ISSN] 0142-9612
  • [Journal-full-title] Biomaterials
  • [ISO-abbreviation] Biomaterials
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hydrogels; 0 / Integrin alpha Chains; 0 / Integrin beta Chains; 0 / Peptides; 30IQX730WE / Polyethylene Glycols; EC 3.4.24.- / Metalloendopeptidases
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58. Saltman B, Singh B, Hedvat CV, Wreesmann VB, Ghossein R: Patterns of expression of cell cycle/apoptosis genes along the spectrum of thyroid carcinoma progression. Surgery; 2006 Dec;140(6):899-905; discussion 905-6
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  • BACKGROUND: Genetic screening studies suggest that genetic changes underlie progression from well differentiated to anaplastic thyroid cancers.
  • METHODS: Tissue microarrarys (TMAs) were constructed from well-differentiated papillary thyroid carcinoma (WDPTC; n = 41), poorly differentiated thyroid carcinoma (PDTC; n = 43), and anaplastic thyroid carcinoma (ATC; n = 22).
  • CONCLUSIONS: These data confirm the presence of increasing genetic complexity with progressive dedifferentiation in thyroid cancer, with aberrant tumor suppressor activity and increased proliferative activity being most prevalent in ATC.
  • [MeSH-minor] Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Cyclin D1 / genetics. Cyclin D1 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / genetics. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Disease Progression. Humans. Ki-67 Antigen / genetics. Ki-67 Antigen / metabolism. Microarray Analysis. Predictive Value of Tests. Prognosis. Proliferating Cell Nuclear Antigen / genetics. Proliferating Cell Nuclear Antigen / metabolism. Proto-Oncogene Proteins c-bcl-2 / genetics. Proto-Oncogene Proteins c-bcl-2 / metabolism. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 17188136.001).
  • [ISSN] 0039-6060
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / p27 antigen; 136601-57-5 / Cyclin D1; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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59. Akatsu T, Ueda M, Shimazu M, Wakabayashi G, Aiura K, Tanabe M, Kawachi S, Kameyama K, Kitajima M: Primary undifferentiated spindle-cell carcinoma of the gallbladder presenting as a liver tumor. J Gastroenterol; 2005 Oct;40(10):993-8
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  • There is very little information available regarding the characteristics and treatment of this disease.
  • Small foci of well-differentiated adenocarcinoma cells were identified in the gallbladder mucosa.
  • However, she died of recurrent liver disease 6 months after the surgery.
  • In conclusion, we surmised that the sarcomatous spindle cells originated from a carcinomatous component in the gallbladder mucosa through dedifferentiation.

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  • (PMID = 16261437.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 29
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60. Tabori U, Wong V, Ma J, Shago M, Alon N, Rutka J, Bouffet E, Bartels U, Malkin D, Hawkins C: Telomere maintenance and dysfunction predict recurrence in paediatric ependymoma. Br J Cancer; 2008 Oct 7;99(7):1129-35
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  • In all 133 tumours, hTERT expression correlated with proliferative markers, including MIB-1 index (P<0.0001) and mitotic index (P=0.005), as well as overall tumour grade (P=0.001), but not with other markers of anaplasia.

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  • (PMID = 18797459.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2567068
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61. Tominaga K, Nakanishi Y, Nimura S, Yoshimura K, Sakai Y, Shimoda T: Predictive histopathologic factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma. Dis Colon Rectum; 2005 Jan;48(1):92-100
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  • The clinicopathologic factors investigated included gender, age, tumor location, macroscopic type, tumor size, histologic type and grade, intramucosal growth pattern, lymphatic invasion, venous invasion, degree of focal dedifferentiation at the submucosal invasive front, status of the remaining muscularis mucosa, and the depth and width of submucosal invasion.
  • Univariate analysis showed that lymphatic invasion, focal dedifferentiation at the submucosal invasive front, status of the remaining muscularis mucosa, and depth of submucosal invasion all had a significant influence on lymph node metastasis.
  • Multivariate analysis showed lymphatic invasion (P = 0.014) and high-grade focal dedifferentiation at the submucosal invasive front (P = 0.049) to be independent factors predicting lymph node metastasis.
  • CONCLUSIONS: Lymphatic invasion and high-grade focal dedifferentiation at the submucosal invasive front are important predictors of lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma.

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  • (PMID = 15690664.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Hyun O J, Yoo IeR, Jung CK, Hoon Kim S, Chung SK: F-18 FDG PET/CT findings of dedifferentiated acinic cell carcinoma. Clin Nucl Med; 2010 Jun;35(6):473-4
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  • [Title] F-18 FDG PET/CT findings of dedifferentiated acinic cell carcinoma.
  • [MeSH-major] Cell Dedifferentiation. Fluorodeoxyglucose F18. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20479609.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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63. Young KH, Xie Q, Zhou G, Eickhoff JC, Sanger WG, Aoun P, Chan WC: Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event. Am J Clin Pathol; 2008 Jan;129(1):157-66
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  • The transformation is accompanied by alteration in morphologic features and clinical behaviors.
  • Both lymphomas had identical bcl-2 and immunoglobulin heavy-chain gene breakpoints as assessed by polymerase chain reaction amplification and direct sequencing, indicating that the 2 tumors originated from a common precursor B-cell clone or the PBC-LBL arose from clonal evolution of its preceding FL and "dedifferentiated" into a lymphoblastic stage.
  • [MeSH-minor] Chromosome Breakage. Clone Cells. DNA, Neoplasm / analysis. Disease Progression. Fatal Outcome. Female. Genes, bcl-2. Humans. Immunoglobulin Heavy Chains / genetics. In Situ Hybridization, Fluorescence. Middle Aged. Sequence Analysis, DNA. Translocation, Genetic

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  • (PMID = 18089500.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA36727; United States / NCI NIH HHS / CA / CA84967
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Immunoglobulin Heavy Chains
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64. Bick RJ, Poindexter BJ, Davis RA, Schiess MC: Determination of the site of action of calcitonin gene-related peptide in the alteration of intracellular calcium levels in adult and neonatal rodent myocytes. Peptides; 2005 Nov;26(11):2231-8
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  • Employing real-time fluorescence measurements in cultured, dedifferentiated adult cardiomyocytes, which are known to express a fetal phenotype and exhibit neonatal-like calcium transients, our acquisitions demonstrated a major reduction in intracellular calcium levels.

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  • (PMID = 15979760.001).
  • [ISSN] 0196-9781
  • [Journal-full-title] Peptides
  • [ISO-abbreviation] Peptides
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium Channels, L-Type; 0 / Vasodilator Agents; 83652-28-2 / Calcitonin Gene-Related Peptide; SY7Q814VUP / Calcium
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65. Driesen RB, Verheyen FK, Schaart G, de Mazière A, Viebahn C, Prinzen FW, Lenders MH, Debie W, Totzeck A, Borgers M, Ramaekers FC: Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation. Cardiovasc Pathol; 2009 Jan-Feb;18(1):19-27
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  • [Title] Cardiotin localization in mitochondria of cardiomyocytes in vivo and in vitro and its down-regulation during dedifferentiation.
  • In the present study, we provide evidence for the specific localization of cardiotin in cardiac mitochondria and for its down-regulation during adaptive remodeling (dedifferentiation) of cardiomyocytes.
  • CONCLUSIONS: Our results demonstrate the specific localization of cardiotin in adult cardiomyocyte mitochondria and propose its use as an early marker for cardiomyocyte adaptive remodeling and dedifferentiation.
  • [MeSH-major] Actinin / metabolism. Aortic Valve Insufficiency / metabolism. Cell Dedifferentiation. Down-Regulation. Mitochondria / metabolism. Myocytes, Cardiac / metabolism
  • [MeSH-minor] Animals. Cells, Cultured. Disease Models, Animal. Female. Fluorescent Antibody Technique, Indirect. Heart / embryology. Heart Ventricles / chemistry. Heart Ventricles / metabolism. Heart Ventricles / pathology. Immunohistochemistry. Male. Microscopy, Immunoelectron. Organ Specificity. Papillary Muscles / metabolism. Papillary Muscles / pathology. Papillary Muscles / ultrastructure. Rabbits. Rats. Swine

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  • (PMID = 18402829.001).
  • [ISSN] 1879-1336
  • [Journal-full-title] Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
  • [ISO-abbreviation] Cardiovasc. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / cardiotin; 11003-00-2 / Actinin
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66. Soslow RA: Mixed Müllerian Tumors of the Female Genital Tract. Surg Pathol Clin; 2009 Dec;2(4):707-30
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  • MMMT should be distinguished from endometrioid adenocarcinoma with spindle cell elements, "dedifferentiated" endometrioid carcinoma, and combined adenocarcinoma and neuroendocrine carcinoma.

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  • [Copyright] Copyright © 2009 Elsevier Inc. All rights reserved.
  • (PMID = 26838776.001).
  • [ISSN] 1875-9181
  • [Journal-full-title] Surgical pathology clinics
  • [ISO-abbreviation] Surg Pathol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Adenofibroma / Atypical polypoid adenomyoma / Carcinosarcoma / Female genital tract / Low-grade müllerian/mesodermal adenosarcoma / Malignant mixed mesodermal / Malignant mixed müllerian tumor / Polypoid endometriosis
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67. Macica CM, Liang G, Lankford KL, Broadus AE: Induction of parathyroid hormone-related peptide following peripheral nerve injury: role as a modulator of Schwann cell phenotype. Glia; 2006 Apr 15;53(6):637-48
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  • We also find that PTHrP causes a dramatic increase in the number of Schwann cells that align with and bundle regrowing axons in explants, characteristic of immature, dedifferentiated Schwann cells.
  • We propose that PTHrP acts by promoting the dedifferentiation of Schwann cells, a critical requirement for successful nerve regeneration and an effect consistent with known PTHrP functions in other cellular differentiation programs.
  • [MeSH-minor] Animals. Animals, Newborn. Cell Differentiation / drug effects. Cell Differentiation / physiology. Cell Proliferation / drug effects. Cells, Cultured. Cyclic AMP Response Element-Binding Protein / metabolism. Disease Models, Animal. Ganglia, Spinal / cytology. Ganglia, Spinal / injuries. Ganglia, Spinal / metabolism. Growth Cones / metabolism. Ligation. Mice. Neurons, Afferent / cytology. Neurons, Afferent / metabolism. Peripheral Nerve Injuries. RNA, Messenger / metabolism. Rats. Rats, Sprague-Dawley. Receptor, Parathyroid Hormone, Type 1 / genetics. Sciatic Nerve / cytology. Sciatic Nerve / injuries. Sciatic Nerve / metabolism. Up-Regulation / drug effects. Up-Regulation / physiology

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  • (PMID = 16470617.001).
  • [ISSN] 0894-1491
  • [Journal-full-title] Glia
  • [ISO-abbreviation] Glia
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR 46032; United States / NIDDK NIH HHS / DK / DK 45735; United States / NIDDK NIH HHS / DK / DK062515-23
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP Response Element-Binding Protein; 0 / Parathyroid Hormone-Related Protein; 0 / RNA, Messenger; 0 / Receptor, Parathyroid Hormone, Type 1
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68. Gligorijević J, Djordjević B, Petrović A, Radirević A, Stojanović S: Expression of CD34 in cirrhotic liver--reliance to dedifferentiation. Vojnosanit Pregl; 2010 Jun;67(6):459-62
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  • [Title] Expression of CD34 in cirrhotic liver--reliance to dedifferentiation.
  • The investigation of angiogenic profile of regenerative, dysplastic and nodules of hepatocellular carcinoma aimed at assessing whether vascular profile is in reliance to the process of dedifferentiation of hepatocytes during the course of cirrhosis.
  • RESULTS: The number of capillary unites showed significant differences among nodular types, with the largest number of capillaries in hepatocellular carcinoma as well as strong reliance to dedifferentiation.

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  • (PMID = 20629423.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34
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69. Bojovic B, Crowe DL: Chronologic aging decreases tumor angiogenesis and metastasis in a mouse model of head and neck cancer. Int J Oncol; 2010 Mar;36(3):715-23
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  • Physiologic cell proliferation, differentiation, and aging can result in cell death.
  • However, under the influence of exogenous or endogenous factors cells can undergo pathologic dedifferentiation, immortalization, and neoplastic clone formation.

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  • (PMID = 20126992.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE14283
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
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70. Madia F, Gattazzo C, Fabrizio P, Longo VD: A simple model system for age-dependent DNA damage and cancer. Mech Ageing Dev; 2007 Jan;128(1):45-9
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  • By combining chronological life span with simple assays for the detection of DNA mutations and dedifferentiation we have developed a powerful system to identify genes that regulate genomic instability and understand the fundamental mechanisms that may be responsible for age-dependent DNA mutations and cancer in mammals.

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  • [ISSN] 0047-6374
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  • [ISO-abbreviation] Mech. Ageing Dev.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / K01 AG001028; United States / NIA NIH HHS / AG / AG20642; United States / NIA NIH HHS / AG / R01 AG025135; United States / NIA NIH HHS / AG / R01 AG020642; United States / NIA NIH HHS / AG / AG01028
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71. Liu R, Li X, Tulpule A, Zhou Y, Scehnet JS, Zhang S, Lee JS, Chaudhary PM, Jung J, Gill PS: KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood; 2010 Jan 28;115(4):887-95
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  • In addition, KSHV induced the expression of endothelial precursor cell marker (CD133) and mural cell markers (calponin, desmin, and smooth muscle alpha actin), suggesting dedifferentiation and trans-differentiation.

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  • (PMID = 19965636.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 079218-07; United States / NCI NIH HHS / CA / R01 CA085177; United States / NCI NIH HHS / CA / CA082057-13; United States / NCI NIH HHS / CA / R01 CA082057; United States / NCI NIH HHS / CA / R01 CA079218; United States / NCI NIH HHS / CA / R01 CA115284; United States / NCI NIH HHS / CA / CA082057; United States / NCI NIH HHS / CA / CA115284; United States / NCI NIH HHS / CA / R01CA085177; United States / NCI NIH HHS / CA / R01 CA031363; United States / NCI NIH HHS / CA / R01 CA082057-13
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / DLL4 protein, human; 0 / Intercellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / NOTCH1 protein, human; 0 / NOTCH2 protein, human; 0 / NOTCH3 protein, human; 0 / NOTCH4 protein, human; 0 / Proto-Oncogene Proteins; 0 / RNA, Small Interfering; 0 / Receptor, Notch1; 0 / Receptor, Notch2; 0 / Receptors, Notch; 134324-36-0 / Serrate proteins
  • [Other-IDs] NLM/ PMC2815507
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72. Arakawa E, Hasegawa K: Benidipine, a calcium channel blocker, regulates proliferation and phenotype of vascular smooth muscle cells. J Pharmacol Sci; 2006 Feb;100(2):149-56
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  • These data suggest that benidipine may arrest the growth of VSMCs, thereby preventing cell dedifferentiation.

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  • (PMID = 16474204.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Calcium Channel Blockers; 0 / Dihydropyridines; 4G9T91JS7E / benidipine; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa
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73. Weksler BB, Subileau EA, Perrière N, Charneau P, Holloway K, Leveque M, Tricoire-Leignel H, Nicotra A, Bourdoulous S, Turowski P, Male DK, Roux F, Greenwood J, Romero IA, Couraud PO: Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J; 2005 Nov;19(13):1872-4
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  • This cell line, termed hCMEC/D3, showed a stable normal karyotype, maintained contact-inhibited monolayers in tissue culture, exhibited robust proliferation in response to endothelial growth factors, and formed capillary tubes in matrix but no colonies in soft agar. hCMEC/D3 cells expressed telomerase and grew indefinitely without phenotypic dedifferentiation.
  • Thus, hCMEC/D3 represents the first stable, fully characterized, well-differentiated human brain endothelial cell line and should serve as a widely usable research tool.

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  • (PMID = 16141364.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Grant] United Kingdom / Multiple Sclerosis Society / / 630; United Kingdom / Multiple Sclerosis Society / / 675; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD31; 0 / Antigens, Polyomavirus Transforming; 0 / Cadherins; 0 / Cytokines; 0 / Drug Combinations; 0 / Laminin; 0 / Proteoglycans; 0 / cadherin 5; 0 / von Willebrand Factor; 119978-18-6 / matrigel; 63231-63-0 / RNA; 9002-18-0 / Agar; 9007-34-5 / Collagen; EC 2.7.7.49 / Telomerase
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74. Kalayarasan R, Ananthakrishnan N, Kate V, Basu D: Estrogen and progesterone receptors in esophageal carcinoma. Dis Esophagus; 2008;21(4):298-303
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  • The receptor status was correlated with tumor type, tumor differentiation and tumor stage.
  • For SCC it was seen that ERbeta positivity in tumor cells increases with dedifferentiation and increasing tumor stage.
  • ERbeta is over-expressed in poorly differentiated SCC and AC compared to NEM.
  • Thus ERbeta may be a marker for poor biological behavior, that is dedifferentiation or higher stage of disease.

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  • (PMID = 18477250.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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75. Famulski KS, Einecke G, Sis B, Mengel M, Hidalgo LG, Kaplan B, Halloran PF: Defining the canonical form of T-cell-mediated rejection in human kidney transplants. Am J Transplant; 2010 Apr;10(4):810-20
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  • Despite marked changes in transcriptome indicating tissue injury and dedifferentiation, all kidneys with molecularly defined TCMR, even with v lesions or late rejection, demonstrated excellent recovery of function at 6 months with no graft loss (mean follow-up 2.5 years).

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  • (PMID = 20132168.001).
  • [ISSN] 1600-6143
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, Thadhani R, Bonventre JV: Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol; 2005 Apr;16(4):1126-34
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  • Human kidney injury molecule-1 (hKIM-1) is a type 1 transmembrane protein that is not detectable in normal kidney tissue but is expressed at high levels in human and rodent kidneys with dedifferentiated proximal tubule epithelial cells after ischemic or toxic injury.

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  • (PMID = 15744000.001).
  • [ISSN] 1046-6673
  • [Journal-full-title] Journal of the American Society of Nephrology : JASN
  • [ISO-abbreviation] J. Am. Soc. Nephrol.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK38452; United States / NIDDK NIH HHS / DK / DK46267; United States / NIDDK NIH HHS / DK / 5F32DK10036; United States / NIDDK NIH HHS / DK / 5KO8DK64075; United States / NIDDK NIH HHS / DK / R37 DK039773; United States / NIDDK NIH HHS / DK / DK39773; United States / NIDDK NIH HHS / DK / K08 DK064075; United States / NIDDK NIH HHS / DK / F32 DK010036; United States / NIDDK NIH HHS / DK / R01 DK046267; United States / NIDDK NIH HHS / DK / P01 DK038452; United States / NIDDK NIH HHS / DK / R01 DK039773
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HAVCR1 protein, human; 0 / Membrane Glycoproteins; 0 / Receptors, Virus
  • [Other-IDs] NLM/ NIHMS4429; NLM/ PMC1307501
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77. Vial C, Zúñiga LM, Cabello-Verrugio C, Cañón P, Fadic R, Brandan E: Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation. J Cell Physiol; 2008 May;215(2):410-21
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  • [Title] Skeletal muscle cells express the profibrotic cytokine connective tissue growth factor (CTGF/CCN2), which induces their dedifferentiation.
  • CTGF had an important inhibitory effect on muscle differentiation evaluated by the decrease in the nuclear translocation of the early muscle regulatory factor myogenin and myosin.
  • Remarkable, CTGF treatment of myoblasts induced their dedifferentiation, characterized by down regulating MyoD and desmin, two markers of committed myoblasts, together with a strong reorganization of cytoskeletal filaments.
  • These results provide novel evidence for the underlying mechanisms and participation of skeletal muscle cells in the synthesis and role of CTGF inducing fibrosis, inhibiting myogenesis and dedifferentiating myoblasts.
  • [MeSH-major] Cell Dedifferentiation. Immediate-Early Proteins / metabolism. Intercellular Signaling Peptides and Proteins / metabolism. Muscle, Skeletal / cytology. Muscle, Skeletal / metabolism
  • [MeSH-minor] Animals. Biological Transport / drug effects. Cell Differentiation / drug effects. Cell Line. Cell Nucleus / metabolism. Connective Tissue Growth Factor. Cytoskeleton / drug effects. Desmin / metabolism. Down-Regulation. Extracellular Matrix Proteins / biosynthesis. Lysophospholipids / pharmacology. Mice. Muscle Fibers, Skeletal / drug effects. Muscle Fibers, Skeletal / metabolism. MyoD Protein / metabolism. Myoblasts / cytology. Myoblasts / drug effects. Myoblasts / metabolism. Myogenin / metabolism. Myosins / metabolism. Recombinant Proteins / pharmacology. Transforming Growth Factor beta / pharmacology

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18064627.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ctgf protein, mouse; 0 / Desmin; 0 / Extracellular Matrix Proteins; 0 / Immediate-Early Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Lysophospholipids; 0 / MyoD Protein; 0 / Myogenin; 0 / Recombinant Proteins; 0 / Transforming Growth Factor beta; 139568-91-5 / Connective Tissue Growth Factor; 22002-87-5 / lysophosphatidic acid; EC 3.6.4.1 / Myosins
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78. Damri M, Granot G, Ben-Meir H, Avivi Y, Plaschkes I, Chalifa-Caspi V, Wolfson M, Fraifeld V, Grafi G: Senescing cells share common features with dedifferentiating cells. Rejuvenation Res; 2009 Dec;12(6):435-43
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  • [Title] Senescing cells share common features with dedifferentiating cells.
  • Dedifferentiation signifies the capacity of somatic cells to acquire stem cell-like properties.
  • Dedifferentiation also characterizes the transition of differentiated leaf cells into protoplasts (plant cells devoid of cell walls), a transition accompanied by widespread chromatin decondensation.
  • Transcriptome profiling of dedifferentiating protoplast cells revealed striking similarities with senescing cells; both display a large increase in the expression of genes of specific transcription factor (TF) families, including ANAC, WRKY, bZIP, and C2H2.
  • Further analysis showed that leaves induced to senesce by exposure to dark display characteristic features of dedifferentiating cells, including chromatin decondensation, disruption of the nucleolus, and condensation of rRNA genes.
  • Considering that premature senescence can be induced by various stress conditions both in plant and animal cells, our results suggest that the response of plant and also animal cells to certain stresses converges on cellular dedifferentiation whereby cells first acquire stem cell-like state prior to acquisition of a new cell fate (e.g., reentry into the cell cycle or death).
  • [MeSH-major] Arabidopsis / cytology. Cell Aging / physiology. Cell Dedifferentiation / physiology

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  • (PMID = 20041737.001).
  • [ISSN] 1557-8577
  • [Journal-full-title] Rejuvenation research
  • [ISO-abbreviation] Rejuvenation Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Ribosomal; 0 / Transcription Factors; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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79. Sellaro TL, Ravindra AK, Stolz DB, Badylak SF: Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds. Tissue Eng; 2007 Sep;13(9):2301-10
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  • SECs represent a highly specialized endothelial cell (EC) population, and traditional methods of SEC isolation from the liver initiate a process of SEC dedifferentiation.
  • The effect of the ECM substrate upon SEC dedifferentiation was evaluated using scanning electron microscopy (SEM) and confocal microscopy.
  • When SECs alone were cultured on uncoated glass slides, collagen I, UBM-ECM, or SIS-ECM, SECs showed signs of dedifferentiation after 1 day.
  • In contrast, SECs alone cultured on L-ECM maintained their differentiated phenotype for at least 3 days, indicated by the presence of many fenestrations on SEC surface, expression of anti-rat hepatic sinusoidal endothelial cells mouse IgG MoAb (SE-1), and lack of expression of CD31.
  • At all time points, SECs cocultured with hepatocytes on L-ECM maintained the greatest degree of differentiation.
  • The present study demonstrated that the acellular ECM scaffold derived from the liver maintained SEC differentiation in culture longer than any of the tested substrate materials.

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  • (PMID = 17561801.001).
  • [ISSN] 1076-3279
  • [Journal-full-title] Tissue engineering
  • [ISO-abbreviation] Tissue Eng.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials
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80. Nakamura Y, Yumiba T, Yamasaki Y, Momiyama T, Ito A, Akamaru Y, Kasugai T: Dedifferentiated liposarcoma in the retroperitoneum in an atomic bomb survivor: report of a case. Case Rep Gastroenterol; 2008;2(3):338-45
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  • [Title] Dedifferentiated liposarcoma in the retroperitoneum in an atomic bomb survivor: report of a case.
  • The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differentiated liposarcoma.
  • By the presence of the liposarcoma, tumor 1 and 2 were thought to be the dedifferentiated areas of liposarcomas.

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  • (PMID = 21490866.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3075194
  • [Keywords] NOTNLM ; Atomic bomb survivor / Dedifferentiated liposarcoma / Malignant fibrous histiocytoma
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81. Durcova-Hills G, Tang F, Doody G, Tooze R, Surani MA: Reprogramming primordial germ cells into pluripotent stem cells. PLoS One; 2008;3(10):e3531
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  • However, PGCs can be induced to dedifferentiate back to a pluripotent state as embryonic germ (EG) cells when exposed to exogenous signaling molecules, FGF-2, LIF and SCF.
  • METHODOLOGY AND PRINCIPAL FINDINGS: Here we show that Trichostatin A (TSA), an inhibitor of histone deacetylases, is a highly potent agent that can replace FGF-2 to induce dedifferentiation of PGCs into EG cells.
  • A key early event during dedifferentiation of PGCs in response to FGF-2 or TSA is the down-regulation of Blimp1, which reverses and apparently relieves the cell fate restriction imposed by it.
  • CONCLUSIONS/SIGNIFICANCE: We propose that dedifferentiation of PGCs into EG cells may provide significant mechanistic insights on early events associated with reprogramming of committed cells to a pluripotent state.
  • [MeSH-major] Cell Dedifferentiation / physiology. Germ Cells / physiology. Pluripotent Stem Cells / physiology

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  • (PMID = 18953407.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G108/500; United Kingdom / Biotechnology and Biological Sciences Research Council / / ; United Kingdom / Medical Research Council / / ; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leukemia Inhibitory Factor; 0 / Lif protein, mouse; 0 / Prdm1 protein, mouse; 0 / STAT3 Transcription Factor; 0 / Stat3 protein, mouse; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2567847
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82. Al-Attar A, Gossage L, Fareed KR, Shehata M, Mohammed M, Zaitoun AM, Soomro I, Lobo DN, Abbotts R, Chan S, Madhusudan S: Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers. Br J Cancer; 2010 Feb 16;102(4):704-9
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  • In gastro-oesophageal cancers previously exposed to neoadjuvant chemotherapy, 34.8% (16 out of 46) of tumours were positive in the nucleus and this correlated with shorter overall survival (P=0.005), whereas cytoplasmic localisation correlated with tumour dedifferentiation (P=0.034).
  • Absence of cytoplasmic staining was associated with perineural invasion (P=0.007), vascular invasion (P=0.05), and poorly differentiated tumours (P=0.068).


83. Ricarte-Filho JC, Fuziwara CS, Yamashita AS, Rezende E, da-Silva MJ, Kimura ET: Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid Cancer. Transl Oncol; 2009 Dec;2(4):236-41
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  • [Title] Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid Cancer.
  • Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy and RET/PTC rearrangements represent key genetic events frequently associated to this cancer, enhancing proliferation and dedifferentiation by activation of the RET/PTC-RAS-BRAF-mitogen-activated protein kinase (MAPK) pathway.
  • In addition, let-7 enhanced transcriptional expression of molecular markers of thyroid differentiation such as TITF1 and TG.
  • Moreover, let-7f effects on thyroid growth and differentiation might attenuate neoplastic process of RET/PTC papillary thyroid oncogenesis through impairment of MAPK signaling pathway activation.
  • This is the first functional demonstration of an association of let-7 with thyroid cancer cell growth and differentiation.


84. Bussolati B, Camussi G: Stem cells in acute kidney injury. Contrib Nephrol; 2007;156:250-8
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  • The administered SCs may, however, modify the microenvironment by inducing dedifferentiation and proliferation of tubular cells surviving to injury or by allowing expansion of resident SCs.
  • Therefore, therapeutic strategies to exploit the regenerative potential of SCs may be based on the administration of ex vivo expanded SCs or on stimulation of expansion and differentiation of local progenitor/SC populations.
  • [MeSH-minor] Animals. Bone Marrow Cells / cytology. Bone Marrow Cells / physiology. Cell Differentiation / physiology. Cell Movement / physiology. Disease Models, Animal. Humans. Kidney / cytology. Kidney / pathology. Kidney / physiology. Rats. Regeneration / physiology

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  • (PMID = 17464134.001).
  • [ISSN] 0302-5144
  • [Journal-full-title] Contributions to nephrology
  • [ISO-abbreviation] Contrib Nephrol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 37
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85. Takano Y, Yamauchi K, Hiramatsu N, Kasai A, Hayakawa K, Yokouchi M, Yao J, Kitamura M: Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin. Am J Physiol Renal Physiol; 2007 May;292(5):F1573-82
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  • VRAD maintained expression of nephrin for extended periods, which was associated with the differentiated phenotype of podocytes.
  • Using the VRAD-primed podocytes, we revealed that expression of nephrin mRNA as well as nephrin promoter activity was suppressed by a putative dedifferentiation factor of podocytes, hepatocyte growth factor.
  • [MeSH-minor] Animals. Biomarkers / metabolism. Calcitriol / pharmacology. Cell Differentiation. Cell Line. Culture Media / pharmacology. Dexamethasone / pharmacology. Drug Combinations. Gene Expression / drug effects. Glucocorticoids / pharmacology. Humans. Mice. Promoter Regions, Genetic / drug effects. RNA, Messenger / metabolism. Recombinant Proteins / pharmacology. Time Factors. Tretinoin / pharmacology

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  • (PMID = 17244893.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Culture Media; 0 / Drug Combinations; 0 / Glucocorticoids; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Recombinant Proteins; 0 / nephrin; 5688UTC01R / Tretinoin; 67256-21-7 / Hepatocyte Growth Factor; 7S5I7G3JQL / Dexamethasone; FXC9231JVH / Calcitriol
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86. Weinberg N, Ouziel-Yahalom L, Knoller S, Efrat S, Dor Y: Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells. Diabetes; 2007 May;56(5):1299-304
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  • [Title] Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells.
  • Recent studies have raised the possibility that human beta-cells can undergo dedifferentiation and give rise to highly proliferative mesenchymal cells, which retain the potential to redifferentiate into beta-cells.
  • To directly test whether cultured beta-cells dedifferentiate, we applied genetic lineage tracing in mice.
  • Differentiated beta-cells were heritably labeled using the Cre-lox system, and their fate in culture was followed.
  • We provide evidence that mouse beta-cells can undergo dedifferentiation in vitro into an insulin-, pdx1-, and glut2-negative state.
  • However, dedifferentiated beta-cells only rarely proliferate under standard culture conditions and are eventually eliminated from cultures.
  • [MeSH-major] Cell Differentiation / physiology. Cell Division / physiology. Insulin-Secreting Cells / cytology

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  • (PMID = 17303800.001).
  • [ISSN] 1939-327X
  • [Journal-full-title] Diabetes
  • [ISO-abbreviation] Diabetes
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Insulin; 147336-22-9 / Green Fluorescent Proteins
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87. D'Alise AM, Amabile G, Iovino M, Di Giorgio FP, Bartiromo M, Sessa F, Villa F, Musacchio A, Cortese R: Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther; 2008 May;7(5):1140-9
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  • The demonstration that the small synthetic molecule reversine [2-(4-morpholinoanilino)-N6-cyclohexyladenine] promotes the dedifferentiation of committed cells into multipotent progenitor-type cells has raised hopes on the exploitation of this small chemical tool for the generation of stem cells.
  • [MeSH-minor] Aurora Kinase B. Aurora Kinases. Binding Sites / drug effects. Cell Differentiation. Cell Line, Tumor. Cell Proliferation. Dose-Response Relationship, Drug. HeLa Cells. Histones / metabolism. Humans. Models, Molecular. Phosphorylation. Polyploidy

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  • (PMID = 18483302.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Histones; 0 / Morpholines; 0 / Protein Kinase Inhibitors; 0 / Purines; EC 2.7.11.1 / AURKB protein, human; EC 2.7.11.1 / Aurora Kinase B; EC 2.7.11.1 / Aurora Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; Z499CLJ023 / 2-(4-morpholinoanilino)-6-cyclohexylaminopurine
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88. Alsaad KO, Serra S, Perren A, Hsieh E, Chetty R: CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix. Int J Surg Pathol; 2007 Jul;15(3):252-7
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  • Conversely, the loss of expression of CD99 has been suggested to play a role in the tumorigenesis and dedifferentiation and is associated with poor outcome in some malignancies.

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  • (PMID = 17652531.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Keratin-19
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89. Schmal H, Mehlhorn AT, Fehrenbach M, Müller CA, Finkenzeller G, Südkamp NP: Regulative mechanisms of chondrocyte adhesion. Tissue Eng; 2006 Apr;12(4):741-50
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  • Therefore, our objective was to study the influence of differentiation status on cellular attachment.
  • Following dedifferentiation after the second passage, adhesion to collagen types I (-84%) and II (-46%) decreased, whereas adhesion to fibrinogen (+59%) and fibronectin (+43%) increased.
  • Matrix design in cartilage engineering must meet the biological demands of amplified cells, because adhesion of chondrocytes depends on their differentiation status and is regulated by bFGF.
  • [MeSH-minor] Animals. Cattle. Cell Adhesion. Cell Culture Techniques. Cell Differentiation. Cells, Cultured. Collagen Type I / pharmacology. Collagen Type I / physiology. Collagen Type I / ultrastructure. Collagen Type II / pharmacology. Collagen Type II / physiology. Collagen Type II / ultrastructure. Dose-Response Relationship, Drug. Extracellular Matrix / physiology. Extracellular Matrix / ultrastructure. Fibrinogen / pharmacology. Fibrinogen / physiology. Fibroblast Growth Factor 2 / pharmacology. Fibronectins / physiology. Focal Adhesions / physiology. Focal Adhesions / ultrastructure. Patella / cytology

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  • (PMID = 16674288.001).
  • [ISSN] 1076-3279
  • [Journal-full-title] Tissue engineering
  • [ISO-abbreviation] Tissue Eng.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type II; 0 / Fibronectins; 103107-01-3 / Fibroblast Growth Factor 2; 9001-32-5 / Fibrinogen
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90. Nasr M, Ayyad SB, El-Lamie IK, Mikhail MY: Expression of matrix metalloproteinase-2 in preinvasive and invasive carcinoma of the uterine cervix. Eur J Gynaecol Oncol; 2005;26(2):199-202
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  • PURPOSE: To study the immunohistochemical expression of matrix metalloproteinase-2 (MMP-2) in preinvasive and invasive carcinoma of the uterine cervix so as to demonstrate whether the expression of MMP-2 is an early or late event in the process of dedifferentiation and cancer progression.
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic / metabolism. Disease Progression. Female. Humans. Middle Aged

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  • (PMID = 15857029.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] EC 3.4.24.24 / Matrix Metalloproteinase 2
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91. Driesen RB, Verheyen FK, Debie W, Blaauw E, Babiker FA, Cornelussen RN, Ausma J, Lenders MH, Borgers M, Chaponnier C, Ramaekers FC: Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies. J Cell Mol Med; 2009 May;13(5):896-908
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  • [Title] Re-expression of alpha skeletal actin as a marker for dedifferentiation in cardiac pathologies.
  • Differentiation of foetal cardiomyocytes is accompanied by sequential actin isoform expression, i.e. down-regulation of the 'embryonic' alpha smooth muscle actin, followed by an up-regulation of alpha skeletal actin (alphaSKA) and a final predominant expression of alpha cardiac actin (alphaCA).
  • Our objective was to detect whether re-expression of alphaSKA occurred during cardiomyocyte dedifferentiation, a phenomenon that has been observed in different pathologies characterized by myocardial dysfunction.
  • Furthermore, actin isoform expression was investigated in left ventricle samples of rabbit hearts suffering from pressure- and volume-overload and in adult rabbit ventricular cardiomyocytes during dedifferentiation in vitro.
  • Dedifferentiating cardiomyocytes in vitro revealed a degradation of the contractile apparatus and local re-expression of alphaSKA.
  • The expression of alphaSKA in adult dedifferentiating cardiomyocytes, in combination with PAS-positive glycogen and decreased cardiotin expression, offers an additional tool in the evaluation of myocardial dysfunction and indicates major changes in the contractile properties of these cells.
  • [MeSH-major] Actins / metabolism. Cell Dedifferentiation / physiology. Myocytes, Cardiac / metabolism. Myocytes, Cardiac / pathology
  • [MeSH-minor] Actinin / metabolism. Animals. Aortic Valve Insufficiency / metabolism. Aortic Valve Insufficiency / pathology. Atrial Fibrillation / metabolism. Atrial Fibrillation / pathology. Biomarkers / metabolism. Cells, Cultured. Coronary Artery Disease / metabolism. Coronary Artery Disease / pathology. Down-Regulation / physiology. Female. Glycogen / metabolism. Goats. Humans. Myocardial Stunning / metabolism. Myocardial Stunning / pathology. Protein Isoforms / metabolism. Rabbits. Up-Regulation / physiology

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  • (PMID = 19538254.001).
  • [ISSN] 1582-4934
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers; 0 / Protein Isoforms; 0 / cardiotin; 11003-00-2 / Actinin; 9005-79-2 / Glycogen
  • [Other-IDs] NLM/ PMC3823406
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92. Löfstedt T, Fredlund E, Noguera R, Navarro S, Holmquist-Mengelbier L, Beckman S, Påhlman S, Axelson H: HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells. Exp Cell Res; 2009 Jul 1;315(11):1924-36
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  • Tumor hypoxia and HIF expression have also been associated with a dedifferentiated phenotype and increased aggressiveness.

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  • (PMID = 19254710.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / MXI1 protein, human; 0 / RNA, Small Interfering; 0 / Tumor Suppressor Proteins
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93. Zhang C, Fu X, Chen P, Bao X, Li F, Sun X, Lei Y, Cai S, Sun T, Sheng Z: Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells. J Cell Mol Med; 2010 May;14(5):1135-45
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  • [Title] Dedifferentiation derived cells exhibit phenotypic and functional characteristics of epidermal stem cells.
  • Differentiated epidermal cells can dedifferentiate into stem cells or stem cell-like cells in vivo.
  • In this study, we report the isolation and characterization of dedifferentiation-derived cells.
  • Then we isolated these cells on the basis of rapid adhesion to type IV collagen and found that there were 4.56% adhering cells (dedifferentiation-derived cells) in the grafting group within 10 min.
  • The in vitro phenotypic assays showed that the expressions of CK19, beta1-integrin, Oct4 and Nanog in dedifferentiation-derived cells were remarkably higher than those in the control group (differentiated epidermal cells) (P < 0.01).
  • In addition, the results of the functional investigation of dedifferentiation-derived cells demonstrated:.
  • (2) more cells were in S phase and G2/M phase of the cell cycle (proliferation index values were 21.02% in control group, 45.08% in group of dedifferentiation);.
  • (3) the total days of culture (28 days versus 130 days), the passage number of cells (3 passages versus 20 passages) and assumptive total cell output (1 x 10(5) cells versus 1 x 10(12) cells) were all significantly increased and (4) dedifferentiation-derived cells, as well as epidermal stem cells, were capable of regenerating a skin equivalent, but differentiated epidermal cells could not.
  • These results suggested that the characteristics of dedifferentiation-derived cells cultured in vitro were similar to epidermal stem cells.
  • [MeSH-major] Cell Dedifferentiation. Epidermis / cytology. Stem Cells / cytology. Stem Cells / metabolism

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  • (PMID = 19426155.001).
  • [ISSN] 1582-4934
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Biomarkers; 0 / Homeodomain Proteins; 0 / Keratin-19; 0 / NANOG protein, human; 0 / Octamer Transcription Factor-3; 0 / POU5F1 protein, human
  • [Other-IDs] NLM/ PMC3822750
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94. Liu Y, Jiang X, Yu MK, Dong J, Zhang X, Tsang LL, Chung YW, Li T, Chan HC: Switching from bone marrow-derived neurons to epithelial cells through dedifferentiation and translineage redifferentiation. Cell Biol Int; 2010 Nov;34(11):1075-83
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  • [Title] Switching from bone marrow-derived neurons to epithelial cells through dedifferentiation and translineage redifferentiation.
  • We investigated whether BM-MSCs that had terminally differentiated into the neural or epithelial lineage could be induced to transdifferentiate into the other phenotype in vitro.
  • Our results reveal that neuronal phenotypic cells derived from adult rat bone marrow cells can be switched to epithelial phenotypic cells, or vice versa, by culture manipulation allowing the differentiated cells to go through, first, dedifferentiation and then redifferentiation to another phenotype.
  • Direct transdifferentiation from differentiated neuronal or epithelial phenotype to the other differentiated phenotype cannot be observed even when appropriate culture conditions are provided.
  • Thus, dedifferentiation appears to be a prerequisite for changing fate and differentiating into a different lineage from a differentiated cell population.
  • [MeSH-major] Bone Marrow Cells / cytology. Cell Dedifferentiation. Cell Differentiation. Cell Lineage. Epithelial Cells / cytology. Neurons / cytology

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  • (PMID = 20939829.001).
  • [ISSN] 1095-8355
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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95. Lee JH, Yu SM, Yoon EK, Lee WK, Jung JC, Kim SJ: 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes. J Korean Med Sci; 2007 Oct;22(5):891-7
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  • [Title] 15-deoxy-Delta 12,14-ProstaglandinJ2 regulates dedifferentiation through peroxisome proliferator-activated receptor-gamma-dependent pathway but not COX-2 expression in articular chondrocytes.
  • Peroxisome proliferator-activated receptors-gamma (PPAR-gamma) is critical for phenotype determination at early differentiation stages of mesenchymal cells, whereas its physiological role is unclear.
  • Therefore, we investigated the role of 15-deoxy-Delta(12,14)-prostaglandinJ2 (15d-PGJ2), the natural receptor ligand for PPAR-gamma, on dedifferentiation and inflammatory responses, such as COX-2 expression and PGE2 production, in articular chondrocytes.
  • Our data indicate that the 15d-PGJ2 caused a loss of differentiated chondrocyte phenotype as demonstrated by inhibition of type II collagen and proteoglycan synthesis.
  • The 15d-PGJ2-induced dedifferentiation effect seems to be dependent on PPAR-gamma activation, as the PPRE luciferase activity increased and PPAR-gamma antagonist, BADGE, abolished type II collagen expression.
  • Collectively, our findings suggest that PPAR-gamma-dependent and -independent mechanisms of 15d-PGJ2-induced dedifferentiation and inflammatory responses in articular chondrocytes, respectively.
  • [MeSH-minor] Animals. Cell Differentiation. Dinoprostone / metabolism. Dose-Response Relationship, Drug. Genes, Reporter. Immunoblotting. Rabbits. Time Factors. Transfection

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  • (PMID = 17982241.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / 15-deoxy-delta(12,14)-prostaglandin J2; 0 / PPAR gamma; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone; RXY07S6CZ2 / Prostaglandin D2
  • [Other-IDs] NLM/ PMC2693859
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96. Périgny M, Dion N, Couture C, Lagacé R: [Low grade fibromyxoid sarcoma: a clinico-pathologic analysis of 7 cases]. Ann Pathol; 2006 Dec;26(6):419-25
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  • [Transliterated title] Sarcome fibromyxoïde de bas grade: une étude clinico-pathologique de 7 cas.
  • We describe the clinicopathologic features of 7 new cases of LGFMS including one case of dedifferentiation in a recurrence.
  • MATERIALS AND METHODS: 7 cases obtained from the surgical files of the CHUQ, L'Hôtel-Dieu de Québec or from the consultation files were studied.
  • One of them demonstrated an area of dedifferentiation into a high grade pleomorphic sarcoma, malignant fibrous histiocytoma (MFH) type.

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  • (PMID = 17255901.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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97. Derouiche A, El Attat R, Hentati H, Blah M, Slama A, Chebil M: Emphysematous pyelitis: epidemiological, therapeutic and evolutive features. Tunis Med; 2009 Mar;87(3):180-3
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  • Nephrectomy was done in one patient presenting a thinned -- dedifferentiated -- renal parenchyma.

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  • (PMID = 19537009.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Tunisia
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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98. Kim HJ, Archer E, Escobedo N, Tapscott SJ, Unguez GA: Inhibition of mammalian muscle differentiation by regeneration blastema extract of Sternopygus macrurus. Dev Dyn; 2008 Oct;237(10):2830-43
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  • [Title] Inhibition of mammalian muscle differentiation by regeneration blastema extract of Sternopygus macrurus.
  • Tissue regeneration through stem cell activation and/or cell dedifferentiation is widely distributed across the animal kingdom.
  • By comparison, regeneration in mammals is poor and this may reflect a limited dedifferentiation potential of mature cells.
  • Because mammalian myotubes can dedifferentiate in the presence of newt blastema extract, the present study tested the dedifferentiation induction capability of the blastema from the teleost Sternopygus macrurus (SmBE).
  • Furthermore, SmBE enhanced myoblast proliferation and reversibly inhibited their differentiation.
  • These data suggest the presence of protein factors in SmBE that regulate mammalian muscle physiology and differentiation, but do not support the conservation of a dedifferentiation induction capability by the blastema of S. macrurus.
  • [MeSH-major] Blastomeres. Cell Differentiation. Gymnotiformes. Muscles / cytology

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  • [Copyright] Copyright (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18816861.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R25 GM061222; United States / NCI NIH HHS / CA / U56 CA096286; United States / NIGMS NIH HHS / GM / GM007667-30S1; United States / NIGMS NIH HHS / GM / T34 GM007667; United States / NIGMS NIH HHS / GM / S06 GM008136-310053; United States / NCRR NIH HHS / RR / P20 RR016480-059004; United States / NIGMS NIH HHS / GM / R25GM061222; United States / NCI NIH HHS / CA / U54 CA132383; United States / NCI NIH HHS / CA / U56 CA096286-05; United States / NIGMS NIH HHS / GM / S06 GM008136; United States / NCI NIH HHS / CA / U56 CA096286-010003; United States / NIGMS NIH HHS / GM / S06-GM008136; United States / NCI NIH HHS / CA / U56-CA96286; United States / NCRR NIH HHS / RR / RR16480; United States / NCRR NIH HHS / RR / P20 RR016480
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Extracts
  • [Other-IDs] NLM/ NIHMS96635; NLM/ PMC2651396
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99. Maki N, Tsonis PA, Agata K: Changes in global histone modifications during dedifferentiation in newt lens regeneration. Mol Vis; 2010 Sep 16;16:1893-7
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  • [Title] Changes in global histone modifications during dedifferentiation in newt lens regeneration.
  • After lens removal PECs in dorsal iris dedifferentiate and revert to stem cell-like cells, and transdifferentiate into lens cells.
  • The intensity of stained signal in nucleus of PECs was measured and changes in histone modification during dedifferentiation were evaluated.
  • RESULTS: During dedifferentiation of PECs histone modifications related to gene activation were differentially regulated.
  • Although tri-methylated histone H3 lysine 4 (TriMeH3K4) and acetylated histone H4 (AcH4) were increased, acetylated histone H3 lysine 9 (AcH3K9) was decreased during dedifferentiation.
  • Among all gene repression-related modifications analyzed only tri-methylated histone H3 lysine 27 (TriMeH3K27) showed a significant change.
  • CONCLUSIONS: Histone modifications are dynamically changed during dedifferentiation of PECs.
  • A coordination of gene activation-related modifications, increasing of TriMeH3K4 and AcH4 and decreasing of AcH3K9, as well as regulation of TriMeH3K27, could be a hallmark of chromatin regulation during newt dedifferentiation.

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  • (PMID = 21031136.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY010540; United States / NEI NIH HHS / EY / EY10540
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histones
  • [Other-IDs] NLM/ PMC2956703
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100. Dufour C, Cadusseau J, Varlet P, Surena AL, de Faria GP, Dias-Morais A, Auger N, Léonard N, Daudigeos E, Dantas-Barbosa C, Grill J, Lazar V, Dessen P, Vassal G, Prevot V, Sharif A, Chneiweiss H, Junier MP: Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation. Stem Cells; 2009 Oct;27(10):2373-82
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  • To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes.
  • When astrocytes dedifferentiated with TGF-alpha were submitted to oncogenic stress using gamma irradiation, they acquired cancerous properties: they were immortalized, showed cytogenomic abnormalities, and formed high-grade glioma-like tumors after brain grafting.
  • [MeSH-minor] Animals. Cell Dedifferentiation / drug effects. Cell Dedifferentiation / physiology. Cell Dedifferentiation / radiation effects. Cells, Cultured. Culture Media, Serum-Free / pharmacology. Gamma Rays / adverse effects. Mice. Mice, Inbred C57BL. Mice, Nude. Stem Cell Transplantation. Stress, Physiological / physiology. Stress, Physiological / radiation effects

  • MedlinePlus Health Information. consumer health - Brain Tumors.
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  • (PMID = 19544474.001).
  • [ISSN] 1549-4918
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media, Serum-Free; 0 / Transforming Growth Factor alpha
  • [Other-IDs] NLM/ HALMS439883; NLM/ PMC3245240
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