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6. Khan S, Lloyd C, Szyszko T, Win Z, Rubello D, Al-Nahhas A: PET imaging in endocrine tumours. Minerva Endocrinol; 2008 Jun;33(2):41-52
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  • Being a marker of metabolically active lesions that show high grading and low differentiation, FDG is not ideal for this purpose since the majority of endocrine tumours are slow growing and highly differentiated.
  • It is however useful when dedifferentiation takes place and provides excellent prognostic information.

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  • (PMID = 18414356.001).
  • [ISSN] 0391-1977
  • [Journal-full-title] Minerva endocrinologica
  • [ISO-abbreviation] Minerva Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Gallium Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 71
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7. Chen GG, Vlantis AC, Chak EC, Liu HC, Tong MC, van Hasselt CA: The expression of Bcl-2 family proteins and spontaneous apoptosis in laryngeal carcinomas. Oncol Res; 2006;16(6):273-80
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  • Bak was decreased in moderately differentiated tumors compared to well-differentiated tumors.
  • In contrast to Bak, the expression of Bcl-2 was increased in moderately differentiated tumors compared to well-differentiated tumors.
  • These results indicate that the reduction in Bak may be associated with an increase in tumor grade and dedifferentiation in laryngeal carcinomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Male. Middle Aged. bcl-2 Homologous Antagonist-Killer Protein / analysis. bcl-2-Associated X Protein / analysis

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  • (PMID = 17476972.001).
  • [ISSN] 0965-0407
  • [Journal-full-title] Oncology research
  • [ISO-abbreviation] Oncol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BAK1 protein, human; 0 / BAX protein, human; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2 Homologous Antagonist-Killer Protein; 0 / bcl-2-Associated X Protein
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8. Rhiemeier V, Breitenbach U, Richter KH, Gebhardt C, Vogt I, Hartenstein B, Fürstenberger G, Mauch C, Hess J, Angel P: A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous cell carcinoma of the skin. Am J Pathol; 2006 Apr;168(4):1354-64
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  • Homeostasis of stratified epithelia, such as the epidermis of the skin, is a sophisticated process that represents a tightly controlled balance between proliferation and differentiation.
  • Taps mRNA and protein are restricted to stratified epithelia in mouse embryos and adult tissues, implicating a crucial role for this aspartic proteinase-like gene in differentiation and homeostasis of multilayered epithelia.
  • However, its expression is negatively associated with dedifferentiation and malignant progression in squamous cell carcinomas of the skin.
  • [MeSH-minor] Amino Acid Sequence. Animals. Cell Differentiation. Cell Line, Tumor. Dexamethasone / pharmacology. Epidermis / embryology. Epidermis / metabolism. Epithelium / embryology. Epithelium / metabolism. Female. Gene Expression Regulation, Developmental. Gene Expression Regulation, Neoplastic. Genes, fos. Humans. Mice. Mice, Inbred C57BL. Molecular Sequence Data. Tetradecanoylphorbol Acetate. Transcription Factor AP-1 / antagonists & inhibitors. Transcription Factor AP-1 / metabolism


9. Al-Maghraby HQ, Khalbuss WE, Rao UN, Cieply K, Dacic S, Monaco SE: Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH. Cytojournal; 2010;7:5
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  • [Title] Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH.
  • Well-differentiated liposarcoma (WDLS) can undergo dedifferentiation to a nonlipogenic sarcoma of variable histologic grade.
  • We present a case of dedifferentiated liposarcoma diagnosed by fine-needle aspiration (FNA), using cytomorphology and ancillary studies (immunocytochemistry and fluorescent in-situ hybridization).
  • In addition, the findings were morphologically compatible with the previously resected retroperitoneal dedifferentiated liposarcoma with areas of osteosarcoma.

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  • (PMID = 20436789.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2861822
  • [Keywords] NOTNLM ; Cytopathology / MDM2 / fine needle aspiration biopsy liposarcoma
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10. Jensen JN, Cameron E, Garay MV, Starkey TW, Gianani R, Jensen J: Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology; 2005 Mar;128(3):728-41
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  • To define cell differentiation changes associated with pancreatic regeneration in adult mice, we compared regeneration following caerulein-induced pancreatitis to that of normal pancreatic development.
  • METHODS: By performing comparative histology for adult and embryonic pancreatic markers in caerulein-treated and control pancreas, we addressed cellular proliferation and differentiation (amylase, DBA-agglutinin, insulin, glucagon, beta-catenin, E-cadherin, Pdx1, Nkx6.1, Notch1, Notch2, Jagged1, Jagged2, Hes1), hereby describing the kinetics of tissue restoration.
  • Expression of the Notch target gene Hes1 provides evidence that Notch signaling is reactivated in dedifferentiated pancreatic cells.
  • Although previous studies have suggested a process of acino-to-ductal transdifferentiation in pancreatic regeneration, we find no evidence to suggest that dedifferentiated cells acquire a ductal fate during this process.
  • CONCLUSIONS: Pancreatic regeneration following chemically induced pancreatitis in the mouse occurs predominantly through acinar cell dedifferentiation, whereby a genetic program resembling embryonic pancreatic precursors is reinstated.

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  • (PMID = 15765408.001).
  • [ISSN] 0016-5085
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-61248-03; United States / NIDDK NIH HHS / DK / P30 DK57516
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Membrane Proteins; 0 / Nkx6-1 protein, mouse; 0 / Receptors, Notch; 0 / Trans-Activators; 0 / pancreatic and duodenal homeobox 1 protein; 888Y08971B / Ceruletide
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11. Yaris N, Nas Y, Cobanoglu U, Yavuz MN: Thymic carcinoma in children. Pediatr Blood Cancer; 2006 Aug;47(2):224-7
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  • Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia.
  • However, she died within 15 months due to progressive disease.

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  • (PMID = 16007580.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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12. Mayordomo E, Machado I, Giner F, Kresse SH, Myklebost O, Carda C, Navarro S, Llombart-Bosch A: A tissue microarray study of osteosarcoma: histopathologic and immunohistochemical validation of xenotransplanted tumors as preclinical models. Appl Immunohistochem Mol Morphol; 2010 Oct;18(5):453-61
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  • BACKGROUND: Osteosarcomas (OS) are aggressive neoplasms with a wide range of morphologic patterns.
  • A morphologic evaluation including the different passages in mice was carried out according to the new WHO criteria.
  • The distribution of the cases according to the histopathologic pattern was: 38 osteogenic OS, 8 primary chondrogenic OS, 2 primary telangiectatic OS, 6 parosteal OS, 2 primary small cell OS, 2 primary poorly differentiated OS, 1 primary dedifferentiated OS, and 3 primary pleomorphic MFH-like OS.
  • CONCLUSIONS: An accurate morphologic evaluation using TMAs in original tumor is essential for the OS diagnosis; hence there is no IHC marker that alone distinguishes the OS subtypes.

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  • (PMID = 20436344.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Osteonectin; 104982-03-8 / Osteocalcin
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13. Liu K, Wang K, Yan H: Incomplete digestion preserves chondrocytes from dedifferentiating in long-termed culture on plastic substrate. Tissue Cell; 2009 Feb;41(1):1-11
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  • [Title] Incomplete digestion preserves chondrocytes from dedifferentiating in long-termed culture on plastic substrate.
  • [MeSH-minor] Animals. Antigens, CD29 / genetics. Cell Differentiation / drug effects. Cell Shape / drug effects. Cells, Cultured. Collagen Type II / genetics. Collagen Type II / metabolism. Epiphyses / cytology. Extracellular Matrix / ultrasonography. Focal Adhesion Protein-Tyrosine Kinases / genetics. Male. Microscopy, Electron, Transmission. Plastics. Rats. Rats, Sprague-Dawley. Transcriptional Activation / drug effects

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  • (PMID = 18674789.001).
  • [ISSN] 0040-8166
  • [Journal-full-title] Tissue & cell
  • [ISO-abbreviation] Tissue Cell
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antigens, CD29; 0 / Collagen Type II; 0 / Plastics; EC 2.7.10.2 / Focal Adhesion Protein-Tyrosine Kinases; EC 3.2.1.35 / Hyaluronoglucosaminidase; EC 3.4.24.- / Collagenases
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4. Pluchino S, Zanotti L, Brini E, Ferrari S, Martino G: Regeneration and repair in multiple sclerosis: the role of cell transplantation. Neurosci Lett; 2009 Jun 12;456(3):101-6
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  • Cells play a critical role in reparative regeneration as regenerating structures (cells or tissues) depend on the proliferation without (de)differentiation of parenchymal cells surviving to the injury, proliferation of stem (progenitor) cells resident in the injured tissue, dedifferentiation of mature cells in the remaining tissue, or by the influx of stem cells originating outside the damaged tissue.


15. Bakkelund K, Fossmark R, Nordrum I, Waldum H: Signet ring cells in gastric carcinomas are derived from neuroendocrine cells. J Histochem Cytochem; 2006 Jun;54(6):615-21
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  • In the present study we examined gastric signet ring cell carcinomas for neuroendocrine differentiation.
  • We propose that signet ring cell carcinomas develop by gradual dedifferentiation from ECL cells via signet ring cells with neuroendocrine immunoreactivity toward signet ring cells where the cytoplasm mainly consists of PAS-positive material.
  • This finding could have implications for the classification and understanding of gastric carcinogenesis.
  • [MeSH-minor] Biomarkers / metabolism. Cell Differentiation. Chromogranin A. Chromogranins / metabolism. Gastric Mucosa / metabolism. Gastric Mucosa / pathology. Histidine Decarboxylase / metabolism. Humans. Synaptophysin / metabolism

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  • (PMID = 16344325.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chromogranin A; 0 / Chromogranins; 0 / Synaptophysin; EC 4.1.1.22 / Histidine Decarboxylase
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16. Liebig B, Brabletz T, Staege MS, Wulfänger J, Riemann D, Burdach S, Ballhausen WG: Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett; 2005 Jun 1;223(1):159-67
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  • Twenty-eight (58%) of these cases showed over-expression of mesothelin in a small fraction of tumor cells displaying dedifferentiation and dissemination at the invasion front.

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  • (PMID = 15890249.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / DNA-Binding Proteins; 0 / GPI-Linked Proteins; 0 / HNF1A protein, human; 0 / Hepatocyte Nuclear Factor 1-alpha; 0 / Membrane Glycoproteins; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / mesothelin; 126548-29-6 / Hepatocyte Nuclear Factor 1
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17. Prakash J, de Borst MH, Lacombe M, Opdam F, Klok PA, van Goor H, Meijer DK, Moolenaar F, Poelstra K, Kok RJ: Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury. J Am Soc Nephrol; 2008 Nov;19(11):2086-97
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  • The Rho kinase pathway plays an important role in dedifferentiation of epithelial cells and infiltration of inflammatory cells.
  • Treatment with Y27632-lysozyme substantially inhibited ischemia/reperfusion-induced tubular damage, indicated by reduced staining of the dedifferentiation markers kidney injury molecule 1 and vimentin, and increased E-cadherin relative to controls.

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  • (PMID = 18650485.001).
  • [ISSN] 1533-3450
  • [Journal-full-title] Journal of the American Society of Nephrology : JASN
  • [ISO-abbreviation] J. Am. Soc. Nephrol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Amides; 0 / Ccl2 protein, rat; 0 / Cell Adhesion Molecules; 0 / Chemokine CCL2; 0 / Collagen Type I; 0 / Drug Carriers; 0 / Havcr1protein, rat; 0 / Protein Kinase Inhibitors; 0 / Pyridines; 0 / Tissue Inhibitor of Metalloproteinase-1; 0 / Transforming Growth Factor beta1; 0 / collagen type I, alpha 1 chain; 0 / smooth muscle actin, rat; 138381-45-0 / Y 27632; EC 2.7.11.1 / rho-Associated Kinases; EC 3.2.1.17 / Muramidase
  • [Other-IDs] NLM/ PMC2573003
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18. Bulycheva IV, Makhson AN, Kuz'min IV, Pavlenko TV: [Dedifferentiated chondrosarcoma: problems of diagnosis and treatment]. Arkh Patol; 2009 Jan-Feb;71(1):46-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dedifferentiated chondrosarcoma: problems of diagnosis and treatment].
  • The dedifferentiated form of the tumor was confirmed in 10 (13%) cases.
  • Ultrastructural data on the components of dedifferentiated chondrosarcoma are first presented in the Russian literature.
  • Radical surgery remains to be the method of choice in treating patients with dedifferentiated chondrosarcoma; however, the capabilities of multidrug therapy and irradiation should not be ignored in this form of the tumor.

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  • (PMID = 19514360.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Lectures
  • [Publication-country] Russia (Federation)
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19. Germain S, Collette F: Dissociation of perceptual and motor inhibitory processes in young and elderly participants using the Simon task. J Int Neuropsychol Soc; 2008 Nov;14(6):1014-21
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  • These results can be interpreted by considering that a dedifferentiation process is responsible for the inhibitory deficits presented by older participants.

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  • (PMID = 18954481.001).
  • [ISSN] 1469-7661
  • [Journal-full-title] Journal of the International Neuropsychological Society : JINS
  • [ISO-abbreviation] J Int Neuropsychol Soc
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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20. Shannon BA, Murch A, Cohen RJ: Primary renal synovial sarcoma confirmed by cytogenetic analysis: a lesion distinct from sarcomatoid renal cell carcinoma. Arch Pathol Lab Med; 2005 Feb;129(2):238-40
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  • [Title] Primary renal synovial sarcoma confirmed by cytogenetic analysis: a lesion distinct from sarcomatoid renal cell carcinoma.
  • When this occurs, origin of this unusual tumor type has been the subject of debate in the literature, with a suggestion that previously reported cases may be more correctly described as renal cell carcinoma with sarcomatoid dedifferentiation.


21. Huo W, Zhang K, Nie Z, Li Q, Jin F: Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury. Transplant Rev (Orlando); 2010 Jul;24(3):143-6
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  • Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated proximal renal tubular epithelial cells in damaged regions.
  • Many studies have illustrated the different functions of KIM-1 in various renal diseases including protective functions in acute kidney injury and damaging functions in chronic kidney disease.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20447817.001).
  • [ISSN] 1557-9816
  • [Journal-full-title] Transplantation reviews (Orlando, Fla.)
  • [ISO-abbreviation] Transplant Rev (Orlando)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / HAVCR1 protein, human; 0 / Membrane Glycoproteins; 0 / Receptors, Virus
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22. Rinas AC, Ward WG, Kilpatrick SE: Potential sampling error in fine needle aspiration biopsy of dedifferentiated chondrosarcoma: a report of 4 cases. Acta Cytol; 2005 Sep-Oct;49(5):554-9
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  • [Title] Potential sampling error in fine needle aspiration biopsy of dedifferentiated chondrosarcoma: a report of 4 cases.
  • BACKGROUND: Dedifferentiated chondrosarcoma is a rare, poorly understood and often fatal sarcoma that usually manifests as a high grade, non-cartilage-producing sarcoma juxtaposed against a low grade chondrosarcoma.
  • CASES: We retrospectively reviewed 4 cytology samples (3 primary, 1 metastatic) from 3 patients with dedifferentiated chondrosarcoma, initially analyzed by FNAB, emphasizing the potential for sampling error.
  • One 27-year-old man with multiple osteochondromatosis developed a dedifferentiated chondrosarcoma of the left pelvis.
  • In none of the FNAB or CNB specimens were both low and high grade components of dedifferentiated chondrosarcoma recognized.
  • CONCLUSION: Due to sampling error, the diagnosis of dedifferentiated chondrosarcoma may be difficult to establish by cytologic examination alone.
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle / standards. Cartilage / pathology. Disease Progression. Fatal Outcome. Female. Femur / pathology. Femur / radiography. Humans. Male. Middle Aged. Neoplasm Metastasis. Osteosarcoma / pathology. Pelvis / pathology. Pelvis / radiography. Retrospective Studies. Selection Bias

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  • (PMID = 16334036.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Matsumoto T, Kano K, Kondo D, Fukuda N, Iribe Y, Tanaka N, Matsubara Y, Sakuma T, Satomi A, Otaki M, Ryu J, Mugishima H: Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential. J Cell Physiol; 2008 Apr;215(1):210-22
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  • [Title] Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential.
  • When mature adipocytes are subjected to an in vitro dedifferentiation strategy referred to as ceiling culture, these mature adipocytes can revert to a more primitive phenotype and gain cell proliferative ability.
  • We refer to these cells as dedifferentiated fat (DFAT) cells.
  • In the present study, we examined the multilineage differentiation potential of DFAT cells.
  • In vitro differentiation analysis revealed that DFAT cells could differentiate into adipocytes, chondrocytes, and osteoblasts under appropriate culture conditions.
  • In addition, clonally expanded porcine DFAT cells showed the ability to differentiate into multiple mesenchymal cell lineages.
  • [MeSH-major] Adipocytes / cytology. Cell Dedifferentiation. Cell Lineage

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18064604.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Surface
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24. Nicolas MM, Tamboli P, Gomez JA, Czerniak BA: Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases. Hum Pathol; 2010 May;41(5):663-71
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  • [Title] Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
  • In this article, we supplement the few published articles by describing the clinical and pathologic features of pleomorphic and dedifferentiated leiomyosarcoma from 41 patients (27 women and 14 men) with an age range of 25 to 75 years (mean, 56.5 years), representing the largest cohort reported to date.
  • Based on staining for muscle markers in the pleomorphic component, twenty-three cases were designated as pleomorphic leiomyosarcoma, and 7 cases were designated as dedifferentiated leiomyosarcoma (negative for all muscle markers used).
  • Eleven cases, in which tissue was not available for immunhistochemical stains, the question of pleomorphic versus dedifferentiated leiomyosarcoma could not be answered.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20004935.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Calmodulin-Binding Proteins; 0 / Desmin; 0 / Vimentin
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25. Lluis F, Pedone E, Pepe S, Cosma MP: Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion. Cell Stem Cell; 2008 Nov 06;3(5):493-507
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  • Reprogramming of nuclei allows the dedifferentiation of differentiated cells.
  • Reprogrammed clones express ESC-specific genes, lose somatic differentiation markers, become demethylated on Oct4 and Nanog CpG islands, and can differentiate into cardiomyocytes in vitro and generate teratomas in vivo.

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  • [CommentIn] Cell Stem Cell. 2008 Nov 6;3(5):465-6 [18983957.001]
  • (PMID = 18983965.001).
  • [ISSN] 1875-9777
  • [Journal-full-title] Cell stem cell
  • [ISO-abbreviation] Cell Stem Cell
  • [Language] eng
  • [Grant] Italy / Telethon / / TGM03P10; Italy / Telethon / / TGM06S01
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 6-bromoindirubin-3'-oxime; 0 / Homeodomain Proteins; 0 / Indoles; 0 / Nanog Homeobox Protein; 0 / Nanog protein, mouse; 0 / Octamer Transcription Factor-3; 0 / Oximes; 0 / Wnt Proteins; 0 / Wnt3 Protein; 0 / Wnt3A Protein; 0 / Wnt3a protein, mouse; 0 / beta Catenin; EC 2.7.11.26 / Glycogen Synthase Kinase 3
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26. Delmaire C, Krainik A, Tézenas du Montcel S, Gerardin E, Meunier S, Mangin JF, Sangla S, Garnero L, Vidailhet M, Lehéricy S: Disorganized somatotopy in the putamen of patients with focal hand dystonia. Neurology; 2005 Apr 26;64(8):1391-6
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  • Disease severity correlated with underactivation and decreased distance between right hand and lip representations.
  • In the right putamen, ipsilateral to the affected hand, the somatotopic organization was not altered but disease severity also correlated with reduced distances between limbs.
  • CONCLUSION: In dystonia there may be a dedifferentiation of the normally segregated cortico-subcortical sensorimotor maps in the putamen, which may contribute to the loss of functional selectivity of muscle activity observed in these dystonic subjects.

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  • (PMID = 15851729.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. van Timmeren MM, Bakker SJ, Vaidya VS, Bailly V, Schuurs TA, Damman J, Stegeman CA, Bonventre JV, van Goor H: Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol; 2006 Aug;291(2):F456-64
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  • Kim-1 expression was limited to areas with inflammation (MØ), fibrosis (alpha-smooth muscle actin), and tubular damage (osteopontin), and only occasionally with tubular dedifferentiation (vimentin).

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  • (PMID = 16467126.001).
  • [ISSN] 1931-857X
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK072381; United States / NIDDK NIH HHS / DK / DK-39773; United States / NIDDK NIH HHS / DK / DK-72381
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / Havcr1protein, rat; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Vimentin
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28. Liu Y, Ye F, Li Q, Tamiya S, Darling DS, Kaplan HJ, Dean DC: Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology. Invest Ophthalmol Vis Sci; 2009 Nov;50(11):5080-8
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  • The purpose of this study was to investigate the potential role for Zeb1 in EMT leading to the dedifferentiation of retinal pigment epithelial (RPE) cells.
  • METHODS: Real-time PCR was used to examine mRNA expression during RPE dedifferentiation in primary cultures of RPE cells from Zeb1(+/-) mice and after knockdown of Zeb1 by lentivirus shRNA.
  • RESULTS: Zeb1 is overexpressed during RPE dedifferentiation.
  • Heterozygous mutation or shRNA knockdown to prevent this overexpression eliminates the onset of proliferation, loss of epithelial morphology, and pigment, which characterizes RPE dedifferentiation.
  • The authors link Zeb1 expression to cell-cell contact and demonstrate that forcing dedifferentiated RPE cells to adopt cell-cell only contacts via sphere formation reverses the overexpression of Zeb1 and reprograms RPE cells back to a pigmented phenotype.
  • CONCLUSIONS: Overexpression of the EMT transcription factor Zeb1 has an important role in RPE dedifferentiation via its regulation of Mitf.
  • Expression of Zeb1 and, in turn, RPE dedifferentiation, is linked to cell-cell contact, and these contacts can be used to diminish Zeb1 expression and reprogram dedifferentiated RPE cells.

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  • (PMID = 19515996.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY017869; United States / NEI NIH HHS / EY / EY015636; United States / NEI NIH HHS / EY / R24 EY015636; United States / NCRR NIH HHS / RR / P20 RR018733; United States / NEI NIH HHS / EY / EY017869-01A1; United States / NEI NIH HHS / EY / R21 EY017869; United States / NEI NIH HHS / EY / R21 EY017869-02; United States / NEI NIH HHS / EY / R21 EY017869-01A1; United States / NEI NIH HHS / EY / EY017869-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn1a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Homeodomain Proteins; 0 / Kruppel-Like Transcription Factors; 0 / Melanins; 0 / Microphthalmia-Associated Transcription Factor; 0 / Mitf protein, mouse; 0 / RNA, Messenger; 0 / ZEB1 protein, mouse
  • [Other-IDs] NLM/ NIHMS293893; NLM/ PMC3648851
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29. Heyse TJ, Malcherczyk D, Moll R, Timmesfeld N, Wapelhorst J, Fuchs-Winkelmann S, Paletta JR, Schofer MD: CD44: survival and metastasis in chondrosarcoma. Osteoarthritis Cartilage; 2010 Jun;18(6):849-56
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  • RESULTS: Among the 30 patients (median age 50 years) there were 22 conventional chondrosarcomas, two dedifferentiated chondrosarcomas, two extraskeletal chondrosarcomas, and one periostal, mesenchymal, clear cell and myxoid chondrosarcoma each.

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  • [Copyright] Copyright 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20171296.001).
  • [ISSN] 1522-9653
  • [Journal-full-title] Osteoarthritis and cartilage
  • [ISO-abbreviation] Osteoarthr. Cartil.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Protein Isoforms
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30. Fougère-Deschatrette C, Imaizumi-Scherrer T, Strick-Marchand H, Morosan S, Charneau P, Kremsdorf D, Faust DM, Weiss MC: Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo. Stem Cells; 2006 Sep;24(9):2098-109
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  • [Title] Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo.
  • In fetal liver, bipotential hepatoblasts differentiate into hepatocytes and bile duct cells (cholangiocytes).
  • In damaged liver of adult murine animals, when hepatocyte proliferation is compromised, bipotential oval cells emerge, probably from bile ducts, proliferate, and differentiate to regenerate the liver.
  • Although hepatocytes dedifferentiated with loss of apical polarity and other hepatocyte markers, they rapidly activated expression of bile duct/oval cell markers.
  • Furthermore, they can participate in liver regeneration in albumin-urokinase-type plasminogen activator/severe combined immune-deficient mice, where they differentiate in clusters of hepatocytes and occasionally bile ducts.
  • [MeSH-major] Cell Differentiation. Hepatocytes / cytology. Liver / cytology

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  • (PMID = 16946000.001).
  • [ISSN] 1066-5099
  • [Journal-full-title] Stem cells (Dayton, Ohio)
  • [ISO-abbreviation] Stem Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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31. Coco DP, Hirsch MS, Hornick JL: Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol; 2009 Dec;33(12):1795-801
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  • Smoothelin is a smooth muscle-specific cytoskeletal protein exclusively found in differentiated smooth muscle cells.
  • The purpose of this study was to determine whether immunostaining for smoothelin could help distinguish smooth muscle neoplasms from their morphologic mimics, particularly KIT-negative gastrointestinal stromal tumors (GISTs), desmin-positive GISTs, and desmoid fibromatosis.
  • A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas (LMS), 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.
  • None of the GISTs, desmoid tumors, inflammatory myofibroblastic tumors, schwannomas, dedifferentiated liposarcomas, or malignant peripheral nerve sheath tumors showed cytoplasmic reactivity for smoothelin.
  • These findings suggest that the extent and pattern of smoothelin expression may help differentiate between benign and malignant mesenchymal tumors of the GI tract, and may be useful in distinguishing leiomyomas from KIT-negative and/or desmin-positive GISTs.
  • [MeSH-minor] Cell Differentiation. Cell Nucleus / chemistry. Cytoplasm / chemistry. Desmin / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Staging. Predictive Value of Tests. Proto-Oncogene Proteins c-kit / analysis. Sensitivity and Specificity

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  • (PMID = 19950405.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Desmin; 0 / Muscle Proteins; 0 / SMTN protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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32. Kipling D, Jones DL, Smith SK, Giles PJ, Jennert-Burston K, Ibrahim B, Sheerin AN, Evans AJ, Rhys-Willams W, Faragher RG: A transcriptomic analysis of the EK1.Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence. Exp Eye Res; 2009 Feb;88(2):277-85
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  • Data mining shows (i) that EK1.Br retain the characteristic transcriptional fingerprint of keratocytes in vitro (ii) that this phenotype can be distinguished from those of other 'fibroblasts' by groups of highly differentially expressed genes and (iii) that senescence induces a distinct dedifferentiation phenomenon in EK1.Br.

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  • (PMID = 19087878.001).
  • [ISSN] 1096-0007
  • [Journal-full-title] Experimental eye research
  • [ISO-abbreviation] Exp. Eye Res.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / EGH16151
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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33. Kojiro M: Histopathology of liver cancers. Best Pract Res Clin Gastroenterol; 2005 Feb;19(1):39-62
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  • The most valuable information is that in the majority of cases HCC arises as a very well differentiated cancer and proliferates with a stepwise process of dedifferentiation.
  • However, as many HCCs are still detected at an advanced stage, it is also important to understand not only the classical pathologic features of HCC but also unusual features such as scirrhous change, sarcomatous change, fibrolamellar variant, and intra-bile duct or intra-atrial tumor growth.
  • [MeSH-minor] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cell Differentiation. Cholangiocarcinoma / pathology. Humans. Liver / pathology. Precancerous Conditions / blood supply. Precancerous Conditions / pathology

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  • (PMID = 15757804.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 90
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34. Lopez-Garcia MA, Palacios J: Pathologic and molecular features of uterine carcinosarcomas. Semin Diagn Pathol; 2010 Nov;27(4):274-86
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  • Although the diagnosis of UCS is not difficult in most cases, the differential diagnosis may include entities such as undifferentiated or dedifferentiated carcinoma, endometrioid adenocarcinoma with spindle cell elements, sarcomatous overgrowth in a low-grade müllerian adenosarcoma, and pure malignant mesenchymal tumors.

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  • (PMID = 21309261.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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35. Xin M, Small EM, Sutherland LB, Qi X, McAnally J, Plato CF, Richardson JA, Bassel-Duby R, Olson EN: MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev; 2009 Sep 15;23(18):2166-78
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  • Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells (SMCs), culminating in vessel occlusion.
  • Mice lacking both miR-143 and miR-145 are viable and do not display overt abnormalities in smooth muscle differentiation, although they show a significant reduction in blood pressure due to reduced vascular tone.
  • Thus, miR-143 and miR-145 act as integral components of the regulatory network whereby SRF controls cytoskeletal remodeling and phenotypic switching of SMCs during vascular disease.

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  • (PMID = 19720868.001).
  • [ISSN] 1549-5477
  • [Journal-full-title] Genes & development
  • [ISO-abbreviation] Genes Dev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / MIRN145 microRNA, mouse; 0 / MKL1 protein, mouse; 0 / MicroRNAs; 0 / Mirn143 microRNA, mouse; 0 / Nuclear Proteins; 0 / Trans-Activators; 0 / myocardin
  • [Other-IDs] NLM/ PMC2751981
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36. Suzuki Y, Squires DC, Riddiford LM: Larval leg integrity is maintained by Distal-less and is required for proper timing of metamorphosis in the flour beetle, Tribolium castaneum. Dev Biol; 2009 Feb 1;326(1):60-7
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  • Apparently, the partial dedifferentiation of the appendages in these larvae acts to maintain high JH and, hence, prevents metamorphosis.

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  • (PMID = 19022238.001).
  • [ISSN] 1095-564X
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM060122-32; United States / NIGMS NIH HHS / GM / R01 GM060122; United States / NIGMS NIH HHS / GM / 2R01 GM60122; United States / NIGMS NIH HHS / GM / R01 GM060122-31; United States / NIGMS NIH HHS / GM / GM060122-31; United States / NIGMS NIH HHS / GM / R01 GM060122-32
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / RNA, Double-Stranded; 0 / Transcription Factors; 0 / distal-less protein, insect; 8B830OJ2UX / Methoprene
  • [Other-IDs] NLM/ NIHMS93807; NLM/ PMC2762819
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37. Letavernier E, Bruneval P, Mandet C, Duong Van Huyen JP, Péraldi MN, Helal I, Noël LH, Legendre C: High sirolimus levels may induce focal segmental glomerulosclerosis de novo. Clin J Am Soc Nephrol; 2007 Mar;2(2):326-33
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  • [Title] High sirolimus levels may induce focal segmental glomerulosclerosis de novo.
  • However, nephrotic syndrome and FSGS were observed recently in three patients who received sirolimus de novo, without medical history of primary FSGS or CAN.
  • Markers of podocyte differentiation were studied in kidney biopsies of the three patients who received sirolimus de novo and of five patients who switched to sirolimus.
  • Immunohistochemistry showed that some podocytes in FSGS lesions had absent or diminished expression of the podocyte-specific epitopes synaptopodin and p57, reflecting dedifferentiation, and had acquired expression of cytokeratin and PAX2, reflecting a immature fetal phenotype.

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  • [CommentIn] Clin J Am Soc Nephrol. 2007 Mar;2(2):198-9 [17699406.001]
  • (PMID = 17699432.001).
  • [ISSN] 1555-905X
  • [Journal-full-title] Clinical journal of the American Society of Nephrology : CJASN
  • [ISO-abbreviation] Clin J Am Soc Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; W36ZG6FT64 / Sirolimus
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38. Chen NX, Moe SM: Uremic vascular calcification. J Investig Med; 2006 Nov;54(7):380-4
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  • We identified increased expression of bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen) and the bone-specific transcription factor core-binding factor alpha(1) (Cbfalpha(1)) in histologic sections of inferior epigastric arteries obtained from patients with stage V chronic kidney disease or calcific uremic arteriolopathy.
  • This implies that the uremic mileau may lead to dedifferentiation of vascular smooth muscle cells, with subsequent mineralization.
  • Further understanding of the pathophysiology of uremic vascular calcification is needed to design effective therapeutic strategies to intervene with this devastating condition in patients with stage V chronic kidney disease.

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  • (PMID = 17169259.001).
  • [ISSN] 1081-5589
  • [Journal-full-title] Journal of investigative medicine : the official publication of the American Federation for Clinical Research
  • [ISO-abbreviation] J. Investig. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / AHSG protein, human; 0 / Blood Proteins; 0 / Core Binding Factor Alpha 1 Subunit; 0 / RUNX2 protein, human; 0 / alpha-2-HS-Glycoprotein
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39. Zheng JP, Ju D, Jiang H, Shen J, Yang M, Li L: Resveratrol induces p53 and suppresses myocardin-mediated vascular smooth muscle cell differentiation. Toxicol Lett; 2010 Nov 30;199(2):115-22
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  • [Title] Resveratrol induces p53 and suppresses myocardin-mediated vascular smooth muscle cell differentiation.
  • However, little is known about how RSVL affects vascular smooth muscle cells (VSMCs) differentiation.
  • Thus, one might expect that RSVL will promote VSMC differentiation.
  • In an effort to identify the molecular mechanisms whereby RSVL represses VSMC differentiation, we found that RSVL inhibits the transcription of Myocardin (myocd) and Srf, the key VSMC transcriptional regulators.
  • However, knockingdown and overexpressing p53 did not affect RSVL-induced VSMCs phenotypic modulation: this suggests that RSVL may induce VSMC dedifferentiation via p53-independent mechanisms.
  • This study provides the first evidence showing that RSVL induces VSMC dedifferentiation by regulating Myocardin and SRF-mediated VSMC gene transcription.

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  • [Copyright] Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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  • (PMID = 20797428.001).
  • [ISSN] 1879-3169
  • [Journal-full-title] Toxicology letters
  • [ISO-abbreviation] Toxicol. Lett.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL087014-04; United States / NHLBI NIH HHS / HL / R01 HL087014; United States / NHLBI NIH HHS / HL / HL087014; United States / NHLBI NIH HHS / HL / R01 HL087014-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / Serum Response Factor; 0 / Stilbenes; 0 / Trans-Activators; 0 / Tumor Suppressor Protein p53; 0 / myocardin; Q369O8926L / resveratrol
  • [Other-IDs] NLM/ NIHMS231778; NLM/ PMC3155942
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40. Bi D, Nishimura J, Niiro N, Hirano K, Kanaide H: Contractile properties of the cultured vascular smooth muscle cells: the crucial role played by RhoA in the regulation of contractility. Circ Res; 2005 Apr 29;96(8):890-7
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  • Vascular smooth muscle cells (VSMCs) have a remarkable degree of plasticity and in response to vascular injury, they can change to a dedifferentiated state that can be typically seen in cell cultures.

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  • (PMID = 15774857.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amides; 0 / Myosin Light Chains; 0 / Pyridines; 138381-45-0 / Y 27632; 37589-80-3 / Guanosine 5'-O-(3-Thiotriphosphate); EC 2.7.11.13 / Protein Kinase C; EC 3.6.5.2 / rhoA GTP-Binding Protein; SY7Q814VUP / Calcium
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41. Ondrej V, Navrátilová B, Protivánková I, Piterková J, Sedlárová M, Luhová L, Lebeda A: Recondensation level of repetitive sequences in the plant protoplast nucleus is limited by oxidative stress. J Exp Bot; 2010 May;61(9):2395-401
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  • Protoplast cultures are remarkable examples of plant cell dedifferentiation.
  • The state of dedifferentiation is evidenced by changes in cell morphology, genome organization, as well as by the capability of protoplasts to differentiate into multiple types of cells (depending on the type of the stimulus applied).
  • The first change in the genome structure is connected with large-scale chromatin decondensation, affecting chromocentres involving various types of these repetitive sequences.
  • This paper describes not only the de- and recondensation of satellite DNA type I and 5S rDNA repetitive sequences, but it also compares the recondensation level of chromatin with the levels of oxidative stress which were decreased by using an antioxidant, as well as the capabilities of the antioxidative systems within protoplasts, during the first 72 h of their culture.

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  • (PMID = 20363868.001).
  • [ISSN] 1460-2431
  • [Journal-full-title] Journal of experimental botany
  • [ISO-abbreviation] J. Exp. Bot.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Proteins; EC 1.11.1.- / Peroxidases; EC 1.11.1.11 / Ascorbate Peroxidases; EC 1.11.1.6 / Catalase
  • [Other-IDs] NLM/ PMC2877892
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42. Petersson F, Michal M, Franco M, Hes O: Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation - report of a unique case. Int J Clin Exp Pathol; 2010;3(5):534-40
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  • [Title] Chromophobe renal cell carcinoma with liposarcomatous dedifferentiation - report of a unique case.
  • Of the published cases with sarcomatous transformation of CRCC, none have shown liposarcomatous differentiation.
  • Out of a cohort of 250 cases of CRCC, 19 (7.6%) showed sarcomatous differentiation.
  • The patient died from widespread metastatic disease 12 months after nephrectomy.

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  • (PMID = 20606735.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2897100
  • [Keywords] NOTNLM ; Chromophobe renal cell carcinoma / liposarcoma / sarcomatoid / sarcomatous transformation
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43. Reiff T, Tsarovina K, Majdazari A, Schmidt M, del Pino I, Rohrer H: Neuroblastoma phox2b variants stimulate proliferation and dedifferentiation of immature sympathetic neurons. J Neurosci; 2010 Jan 20;30(3):905-15
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  • [Title] Neuroblastoma phox2b variants stimulate proliferation and dedifferentiation of immature sympathetic neurons.
  • Together, these results suggest that PHOX2B mutations predispose to neuroblastoma by increasing proliferation and promoting dedifferentiation of cells in the sympathoadrenergic lineage.
  • [MeSH-major] Cell Differentiation / physiology. Cell Proliferation. Ganglia, Sympathetic / cytology. Homeodomain Proteins / physiology. Mutation / physiology. Transcription Factors / physiology
  • [MeSH-minor] Animals. Basic Helix-Loop-Helix Transcription Factors / genetics. Basic Helix-Loop-Helix Transcription Factors / metabolism. Brain-Derived Neurotrophic Factor / pharmacology. Bromodeoxyuridine / metabolism. Cell Count / methods. Cell Line, Tumor. Cells, Cultured. Chick Embryo. Embryo, Mammalian. Gene Expression Regulation, Developmental / drug effects. Gene Expression Regulation, Developmental / genetics. Gene Expression Regulation, Neoplastic / genetics. Green Fluorescent Proteins / genetics. Histones / metabolism. Immunoprecipitation. Inhibitor of Differentiation Protein 2 / genetics. Inhibitor of Differentiation Protein 2 / metabolism. Mice. Mice, Inbred C57BL. Neuroblastoma. Neurons. RNA, Small Interfering / pharmacology. Tyrosine 3-Monooxygenase / metabolism

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  • (PMID = 20089899.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Brain-Derived Neurotrophic Factor; 0 / Hand2 protein, mouse; 0 / Histones; 0 / Homeodomain Proteins; 0 / Idb2 protein, mouse; 0 / Inhibitor of Differentiation Protein 2; 0 / NBPhox protein; 0 / RNA, Small Interfering; 0 / Transcription Factors; 147336-22-9 / Green Fluorescent Proteins; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; G34N38R2N1 / Bromodeoxyuridine
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44. Weaver J, Downs-Kelly E, Goldblum JR, Turner S, Kulkarni S, Tubbs RR, Rubin BP, Skacel M: Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol; 2008 Aug;21(8):943-9
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  • Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas, respectively.
  • Dual color fluorescence in situ hybridization employing a laboratory-developed BAC label probe cocktail specific for MDM2 (12q15) and a probe for the centromeric region of chromosome 12 (Abbott Molecular, DesPlaines, IL) was performed on formalin-fixed and paraffin-embedded tissue including whole sections from atypical lipomatous tumors (n=13), dedifferentiated liposarcomas (n=14), benign lipomatous tumors (n=30), and pleomorphic sarcoma, not otherwise specified (n=10), and a tissue microarray containing a variety of high-grade sarcomas (n=63).
  • Of the well-differentiated and dedifferentiated liposarcomas, 100% showed amplification of MDM2.
  • The specificity decreases in high-grade sarcomas, as MDM2 amplification was observed in a small portion of pleomorphic sarcomas and high-grade sarcomas other than dedifferentiated liposarcomas.
  • Importantly, none of the benign lipomatous lesions were MDM2 amplified and even cells in areas of well-differentiated liposarcomas with minimal cytologic atypia were amplified, making the probe a valuable tool in the diagnosis of even limited biopsy samples of well-differentiated lipomatous neoplasms.

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  • (PMID = 18500263.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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45. Italiano A, Maire G, Sirvent N, Nuin PA, Keslair F, Foa C, Louis C, Aurias A, Pedeutour F: Variability of origin for the neocentromeric sequences in analphoid supernumerary marker chromosomes of well-differentiated liposarcomas. Cancer Lett; 2009 Jan 18;273(2):323-30
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  • [Title] Variability of origin for the neocentromeric sequences in analphoid supernumerary marker chromosomes of well-differentiated liposarcomas.
  • Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas are cytogenetically characterized by the presence of supernumerary ring or giant chromosomes containing amplified material from the 12q14-15 region.


46. Ambrosini G, Cheema HS, Seelman S, Teed A, Sambol EB, Singer S, Schwartz GK: Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells. Mol Cancer Ther; 2008 Apr;7(4):890-6
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  • MPNST (MPNST and ST8814) and dedifferentiated liposarcoma (LS141 and DDLS) human tumor cell lines were characterized for Ras activation and B-Raf expression.

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  • (PMID = 18413802.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA047179-16; United States / NCI NIH HHS / CA / T32 CA009501-18; United States / NCI NIH HHS / CA / T32 CA009501; United States / NCI NIH HHS / CA / T32 CA009501-17; United States / NCI NIH HHS / CA / P01 CA047179-17; United States / NCI NIH HHS / CA / CA09501; United States / NCI NIH HHS / CA / P01 CA047179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzenesulfonates; 0 / Phenylurea Compounds; 0 / Pyridines; 0 / Retinoblastoma Protein; 136601-57-5 / Cyclin D1; 25X51I8RD4 / Niacinamide; 9ZOQ3TZI87 / sorafenib; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.1 / Proto-Oncogene Proteins c-raf; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS349129; NLM/ PMC3267321
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47. Xu AM, Gong SJ, Song WH, Li XW, Pan CH, Zhu JJ, Wu MC: Primary mixed germ cell tumor of the liver with sarcomatous components. World J Gastroenterol; 2010 Feb 7;16(5):652-6
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  • The predominant components of immature teratoma consisted of several types of tissue that represented different germinal layers (endoderm, mesoderm and ectoderm) and showed varying degrees of differentiation with significant sarcomatous components.
  • The immature teratoma components showed positivity for varying differentiation markers.
  • This suggested that sarcomatous components may be associated with dedifferentiation or malignant transformation of certain mesenchymal components within teratoma.

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  • (PMID = 20128038.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
  • [Other-IDs] NLM/ PMC2816282
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48. Legraverend M, Grierson DS: The purines: potent and versatile small molecule inhibitors and modulators of key biological targets. Bioorg Med Chem; 2006 Jun 15;14(12):3987-4006
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  • Purine-based compounds have found new applications as inducers of interferon and lineage-committed cell dedifferentiation, agonists and antagonists of adenosine receptors, ligands of corticotropin-releasing hormone receptors, and as inhibitors of HSP90, Src kinase, p38alpha MAP kinase, sulfotransferases, phosphodiesterases, and Cdks.
  • [MeSH-minor] Cell Differentiation / drug effects. Humans. Ligands. Molecular Structure. Structure-Activity Relationship

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  • (PMID = 16503144.001).
  • [ISSN] 0968-0896
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Enzyme Inhibitors; 0 / Ligands; 0 / Purines
  • [Number-of-references] 169
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49. Decraene C, Benchaouir R, Dillies MA, Israeli D, Bortoli S, Rochon C, Rameau P, Pitaval A, Tronik-Le Roux D, Danos O, Gidrol X, Garcia L, Piétu G: Global transcriptional characterization of SP and MP cells from the myogenic C2C12 cell line: effect of FGF6. Physiol Genomics; 2005 Oct 17;23(2):132-49
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  • Expression profiles of SPs show that these cells are less differentiated than MPs and display some similarities to stem cells.
  • Moreover, principal component analysis made it possible to distinguish specific contributions of either FGF6 or differentiation effects on gene expression profiles.
  • We propose that FGF6 conditioning could provide a way to expand the pool of immature cells by myoblast dedifferentiation.
  • [MeSH-minor] Animals. Benzimidazoles. Cell Differentiation. Cell Separation. Cells, Cultured. DNA / metabolism. DNA Probes. Down-Regulation / genetics. Flow Cytometry. Gene Expression Profiling. Mice. Microarray Analysis. Principal Component Analysis. Reproducibility of Results. Reverse Transcriptase Polymerase Chain Reaction. Staining and Labeling. Up-Regulation / genetics

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  • (PMID = 16033864.001).
  • [ISSN] 1531-2267
  • [Journal-full-title] Physiological genomics
  • [ISO-abbreviation] Physiol. Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzimidazoles; 0 / DNA Probes; 0 / Fgf6 protein, mouse; 0 / Fibroblast Growth Factor 6; 0 / Proto-Oncogene Proteins; 23491-52-3 / HOE 33342; 9007-49-2 / DNA
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50. Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H, Bouwens L: Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Cell Death Differ; 2006 Nov;13(11):1892-9
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  • This study demonstrates that in vitro growth factor stimulation can induce recapitulation of an embryonic endocrine differentiation pathway in adult dedifferentiated exocrine cells.

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  • (PMID = 16514419.001).
  • [ISSN] 1350-9047
  • [Journal-full-title] Cell death and differentiation
  • [ISO-abbreviation] Cell Death Differ.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK021344
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Growth Substances; 0 / Hepatocyte Nuclear Factor 6; 0 / Nerve Tissue Proteins; 0 / Neurog3 protein, rat; 0 / RNA, Messenger; 0 / STAT3 Transcription Factor; 25X51I8RD4 / Niacinamide; EC 2.7.10.2 / Janus Kinase 2; EC 3.1.1.3 / Lipase
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51. Chinnaiyan P, Wang M, Rojiani AM, Tofilon PJ, Chakravarti A, Ang KK, Zhang HZ, Hammond E, Curran W Jr, Mehta MP: The prognostic value of nestin expression in newly diagnosed glioblastoma: report from the Radiation Therapy Oncology Group. Radiat Oncol; 2008;3:32
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  • Based on the heterogeneous expression of nestin in GBM and its potential to serve as a marker for a dedifferentiated, and perhaps more aggressive phenotype, the Radiation Therapy Oncology Group (RTOG) sought to determine the prognostic value of nestin expression in newly diagnosed GBM patients treated on prior prospective RTOG clinical trials.
  • [MeSH-minor] Antineoplastic Agents, Alkylating / therapeutic use. Cell Lineage. Combined Modality Therapy / methods. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Disease-Free Survival. Humans. Nestin. Neurons / metabolism. Phenotype. Prognosis. Research Design. Treatment Outcome

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  • (PMID = 18817556.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
  • [Other-IDs] NLM/ PMC2563009
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52. Padron Velazquez JL: Stem cell fusion as an ultimate line of defense against xenobiotics. Med Hypotheses; 2006;67(2):383-7
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  • By fusing with somatic de-differentiated cells, stem cells might consent epigenetic reprogramming and/or genetic recovery of genes which otherwise could drive altered cells to malignancy.
  • If the many sophisticated mechanisms of metabolism, cell repair, programmed cell death and tissue regeneration should fail, stem cells might represent a final attempt to recover dedifferentiated cells to avoid inflowing in cancer.
  • [MeSH-minor] Animals. Apoptosis. Cell Differentiation. Cell Fusion. Humans. Mutation. Regeneration

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  • (PMID = 16527429.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Xenobiotics
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53. Hommell-Fontaine J, Borda A, Ragage F, Berger N, Decaussin-Petrucci M: Nonconventional papillary thyroid carcinomas with pleomorphic tumor giant cells: a diagnostic pitfall with anaplastic carcinoma. Virchows Arch; 2010 Jun;456(6):661-70
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  • [Title] Nonconventional papillary thyroid carcinomas with pleomorphic tumor giant cells: a diagnostic pitfall with anaplastic carcinoma.
  • The presence of pleomorphic tumor giant cells in thyroid carcinomas of follicular cell origin is always worrisome for the pathologist as they first of all refer to anaplastic carcinoma, one of the most aggressive human malignancies.
  • However, non-anaplastic pleomorphic giant cells are well described in other thyroid diseases, most often benign.
  • In this paper, we describe four cases of papillary thyroid carcinoma displaying pleomorphic tumor giant cells with features that differ from those of anaplastic carcinoma.
  • Compared to pleomorphic giant cells of anaplastic carcinoma, they reproduced the growth pattern of the underlying carcinoma, had a low mitotic index without necrosis or inflammation, and were reactive with thyroglobulin and thyroid-specific transcription factor-1 and strongly and diffusely positive for cytokeratin AE1/AE3.
  • These cases show that pleomorphic tumor giant cells arising in papillary thyroid carcinomas do not always represent dedifferentiation and progression to anaplastic carcinoma.

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  • (PMID = 20414675.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / TTF1 protein, human; 68238-35-7 / Keratins
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54. Imataki O, Ohnishi H, Yamaoka G, Arai T, Kitanaka A, Kubota Y, Kushida Y, Ishida T, Tanaka T: Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse. Int J Clin Oncol; 2010 Feb;15(1):112-5
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  • Residual disease was proved by biopsy and pathologically shown to have an immature phenotype of CD5+, CD10-, CD20-, CD79a- and myeloperoxidase negativity.
  • This case suggests that leukemic subclones tend to carry out dedifferentiation, occasionally in extramedullary sites, which serve as a hotbed for the selection of resistant clones.

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  • (PMID = 20066454.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
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55. Chung YS, Kim HJ, Kim TM, Hong SH, Kwon KR, An S, Park JH, Lee S, Oh IH: Undifferentiated hematopoietic cells are characterized by a genome-wide undermethylation dip around the transcription start site and a hierarchical epigenetic plasticity. Blood; 2009 Dec 3;114(24):4968-78
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  • Undifferentiated hematopoietic cells also exhibited dynamic chromatin associated with active transcription and a higher turnover of histone acetylation than terminally differentiated cells.
  • In contrast, similar treatments on more mature cells caused partial phenotypic dedifferentiation and apoptosis at levels correlated with their hematopoietic differentiation.
  • [MeSH-major] Cell Differentiation / genetics. DNA Methylation / genetics. Hematopoietic Stem Cells / cytology


56. Stouffer GA, Pathak A, Rojas M: Unilateral renal artery stenosis causes a chronic vascular inflammatory response in ApoE-/- mice. Trans Am Clin Climatol Assoc; 2010;121:252-64; 264-6
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  • Partial constriction of the right renal artery resulted in a mild, sustained increase in systolic blood pressure over the 90 days of the study, whereas there was no change in blood pressure in mice that underwent sham-surgery.
  • Non-muscle myosin-A, a marker of smooth muscle cell dedifferentiation, was observed in atheroma within the abdominal aorta and carotid arteries in mice that underwent unilateral RAL.
  • CONCLUSIONS: Chronic unilateral partial RAL results in the formation of atheroma in the aorta and carotid arteries of ApoE-/- mice that is characterized by chronic inflammation and dedifferentiation of smooth muscle cells.
  • [MeSH-minor] Animals. Aorta, Abdominal / metabolism. Aorta, Abdominal / pathology. Carotid Arteries / metabolism. Carotid Arteries / pathology. Chemokine CCL2 / metabolism. Disease Models, Animal. Hypertension, Renovascular / etiology. Hypertension, Renovascular / physiopathology. Inflammation / etiology. Inflammation / metabolism. Inflammation / pathology. Ligation. Mice. Mice, Inbred C57BL. Mice, Knockout. Muscle, Smooth, Vascular / pathology. Myosin Heavy Chains / metabolism. Plaque, Atherosclerotic / etiology. Plaque, Atherosclerotic / metabolism. Plaque, Atherosclerotic / pathology

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  • (PMID = 20697566.001).
  • [ISSN] 0065-7778
  • [Journal-full-title] Transactions of the American Clinical and Climatological Association
  • [ISO-abbreviation] Trans. Am. Clin. Climatol. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Ccl2 protein, mouse; 0 / Chemokine CCL2; EC 3.6.4.1 / Myosin Heavy Chains
  • [Other-IDs] NLM/ PMC2917126
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57. Stintzing S, Ocker M, Hartner A, Amann K, Barbera L, Neureiter D: Differentiation patterning of vascular smooth muscle cells (VSMC) in atherosclerosis. Virchows Arch; 2009 Aug;455(2):171-85
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  • [Title] Differentiation patterning of vascular smooth muscle cells (VSMC) in atherosclerosis.
  • To investigate the involvement of transdifferentiation and dedifferentiation phenomena inside atherosclerotic plaques, we analyzed the differentiation status of vascular smooth muscle cells (VSMC) in vitro and in vivo.
  • Forty normal autoptic and 20 atherosclerotic carotid endarterectomy specimens as well as 20 specimens of infrarenal and suprarenal aortae were analyzed for the expression of cytokeratins 7 and 18 and beta-catenin as markers (epithelial transdifferentiation) as well as CD31 and CD34 (embryonic dedifferentiation) by conventional and double fluorescence immunohistochemistry and reverse transcription polymerase chain reaction.
  • The expression of those differentiation markers by stimulated HA-VSMC showed a time and cytokine dependency in vitro.
  • Our findings show that (1) VSMC of progressive atheromas have the ability of differentiation, (2) that transdifferentiation and dedifferentiation phenomena are topographically diverse localized in the subregions of advanced atherosclerotic lesions, and (3) are influenced by inflammatory cytokines like IL-1beta, IL-6, and TNF-alpha.
  • [MeSH-major] Carotid Arteries / pathology. Carotid Artery Diseases / pathology. Cell Differentiation. Muscle, Smooth, Vascular / pathology

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  • (PMID = 19557430.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Interleukin-1beta; 0 / Interleukin-6; 0 / Keratin-18; 0 / Keratin-7; 0 / Tumor Necrosis Factor-alpha; 0 / beta Catenin
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58. Huls M, Russel FG, Masereeuw R: Insights into the role of bone marrow-derived stem cells in renal repair. Kidney Blood Press Res; 2008;31(2):104-10
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  • Tubular cells can restore renal function by proliferation and dedifferentiation into a mesenchymal cell type, but also stem cells residing in bone marrow may contribute.
  • [MeSH-major] Acute Kidney Injury / therapy. Cell Differentiation / physiology. Mesenchymal Stem Cell Transplantation. Mesenchymal Stromal Cells / physiology
  • [MeSH-minor] Animals. Bone Marrow Transplantation / physiology. Disease Models, Animal. Mice. Regeneration / physiology. Reperfusion Injury

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18354259.001).
  • [ISSN] 1423-0143
  • [Journal-full-title] Kidney & blood pressure research
  • [ISO-abbreviation] Kidney Blood Press. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 30
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59. Huang Y, Salu K, Wang L, Liu X, Li S, Lorenz G, Wnendt S, Verbeken E, Bosmans J, Van de Werf F, De Scheerder I: Use of a tacrolimus-eluting stent to inhibit neointimal hyperplasia in a porcine coronary model. J Invasive Cardiol; 2005 Mar;17(3):142-8
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  • Stent-induced arterial injury and peri-strut inflammation are involved in the process of neointimal formation by activating cytokines and growth factors which induce smooth muscle cell dedifferentiation, migration, and proliferation.
  • [MeSH-major] Coronary Restenosis / prevention & control. Disease Models, Animal. Immunosuppressive Agents / administration & dosage. Stents. Tacrolimus / administration & dosage. Tunica Intima / drug effects

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  • (PMID = 15867441.001).
  • [ISSN] 1042-3931
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coated Materials, Biocompatible; 0 / Immunosuppressive Agents; P88XT4IS4D / Paclitaxel; WM0HAQ4WNM / Tacrolimus
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60. Lewis GP, Chapin EA, Luna G, Linberg KA, Fisher SK: The fate of Müller's glia following experimental retinal detachment: nuclear migration, cell division, and subretinal glial scar formation. Mol Vis; 2010 Jul 15;16:1361-72
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  • In addition, a subpopulation of anti-BrdU-labeled cells, presumably once Müller cells, appears to stop expressing well accepted Müller cell marker proteins, suggesting a potential dedifferentiation of some of these cells over time.

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  • (PMID = 20664798.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / R01 EY000888; United States / NEI NIH HHS / EY / R01EY000888
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vimentin; G34N38R2N1 / Bromodeoxyuridine
  • [Other-IDs] NLM/ PMC2905639
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61. Martínez-Jiménez CP, Gómez-Lechón MJ, Castell JV, Jover R: Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells. J Biol Chem; 2006 Oct 6;281(40):29840-9
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  • [Title] Underexpressed coactivators PGC1alpha and SRC1 impair hepatocyte nuclear factor 4 alpha function and promote dedifferentiation in human hepatoma cells.
  • Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate.
  • The down-regulation of key HNF4alpha coactivators could be a determinant factor for the dedifferentiation of human hepatomas.
  • [MeSH-minor] Adult. Aged. Cell Differentiation / physiology. Cell Line, Tumor. Female. Homeostasis / physiology. Humans. Liver / metabolism. Male. Middle Aged. Nuclear Receptor Coactivator 1


62. Song T, Shen J, Liang BL, Mai WW, Li Y, Guo HC: Retroperitoneal liposarcoma: MR characteristics and pathological correlative analysis. Abdom Imaging; 2007 Sep-Oct;32(5):668-74
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  • Well-differentiated liposarcoma (n = 5) presented in high signal intensity on T1W images, intermediate signal intensity on T2W images, drop-out signal intensity on fat-suppressed MR images; The enhanced tenuous septa and solid tissues were seen on post-contrast image.
  • Dedifferentiated liposarcoma (n = 3) exhibited small amounts of fatty components with a clear demarcation between fat and nonadipose solid tissue on MR images.
  • One case of dedifferentiated liposarcoma invaded the kidney.

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  • (PMID = 17387533.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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63. Okuda I, Ubara Y, Okuda C, Fujii T, Suwabe T, Kokubo T, Nakajima Y, Hashimoto M: A large calcified retroperitoneal mass in a patient with chronic renal failure: liposarcoma with ossification. Clin Exp Nephrol; 2010 Apr;14(2):185-9
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  • The calcified mass was surgically resected and histopathologically diagnosed as myxoid-type liposarcoma composed of dedifferentiated, myxoid, and well-differentiated components with areas of osseous metaplasia.

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  • (PMID = 19882203.001).
  • [ISSN] 1437-7799
  • [Journal-full-title] Clinical and experimental nephrology
  • [ISO-abbreviation] Clin. Exp. Nephrol.
  • [Language] eng
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  • [Publication-country] Japan
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64. Chen X, Li Z, Hu X, Kusuoka Y: Morphology, morphogenesis and gene sequence of a freshwater ciliate, Pseudourostyla cristata (Ciliophora, Urostyloidea) from the ancient Lake Biwa, Japan. Eur J Protistol; 2010 Jan;46(1):43-60
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  • (1) the oral primordium for the proter originates de novo on the dorsal wall of the buccal cavity, and the dedifferentiated undulating membranes and some parental proximal membranelles join in the primordial development; the old adoral zone will be partly replaced by new structures;.
  • (3) the fronto-midventral transverse cirral (FVT) anlagen develop separately in both dividers by dedifferentiation of most of the midventral cirri;.

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  • [Copyright] Copyright (c) 2008 Elsevier GmbH. All rights reserved.
  • (PMID = 19775875.001).
  • [ISSN] 1618-0429
  • [Journal-full-title] European journal of protistology
  • [ISO-abbreviation] Eur. J. Protistol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ FJ598608
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / RNA, Ribosomal
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65. Saeki H, Tamada Y, Watanabe D, Akita Y, Matsumoto Y, Imai C, Kadono T, Maekawa T, Hattori N, Watanabe A, Torii H, Tamaki K: Analysis of gene mutations in four cases of dermatofibrosarcoma protuberans. Clin Exp Dermatol; 2006 May;31(3):441-4
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  • In one case, the tumour was composed of two areas that differed in cytological atypia, cellularity and mitotic activity, indicating the dedifferentiation of the tumour.
  • These results suggest that the dedifferentiation of tumour cells has nothing to do with the specific breakpoints of the COL1A1 gene, but depends on other unknown factors.

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  • (PMID = 16681596.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Oncogene Proteins, Fusion; 0 / collagen type I, alpha 1 chain
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66. van Staveren WC, Solís DW, Delys L, Duprez L, Andry G, Franc B, Thomas G, Libert F, Dumont JE, Detours V, Maenhaut C: Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype. Cancer Res; 2007 Sep 1;67(17):8113-20
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  • [Title] Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
  • To investigate whether thyroid tumor-derived cell lines are representative in vitro models, characteristics of eight of those cell lines were investigated with microarrays, differentiation markers, and karyotyping.
  • Our results indicate that these cell lines derived from differentiated and undifferentiated tumor types have evolved in vitro into similar phenotypes with gene expression profiles the closest to in vivo undifferentiated tumors.
  • Accordingly, the absence of expression of most thyrocyte-specific genes, the nonresponsiveness to thyrotropin, as well as their large number of chromosomal abnormalities, suggest that these cell lines have acquired characteristics of fully dedifferentiated cells.
  • They represent the outcome of an adaptation and evolution in vitro, which questions the reliability of these cell lines as models for differentiated tumors.
  • However, they may represent useful models for undifferentiated cancers, and by their comparison with differentiated cells, can help to define the genes involved in the differentiation/dedifferentiation process.
  • [MeSH-major] Adenoma / pathology. Carcinoma, Papillary / pathology. Cell Differentiation. Cell Line, Tumor. Thyroid Neoplasms / pathology


67. Barciszewski J, Massino F, Clark BF: Kinetin--a multiactive molecule. Int J Biol Macromol; 2007 Feb 20;40(3):182-92
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  • Kinetin which was isolated 50 years ago for the first time as a plant hormone, as well as other cytokinins isopentenyladenine, zeatin and benzylaminopurine induce callus (clusters of dedifferentiated plant cells) to redifferentiate into adventitious buds.
  • Because of some similarities in the biological phenotypes of cancer and callus cells, cytokinins and especially kinetin, affect the differentiation of human cells through a common signal transduction system.
  • [MeSH-major] Cell Differentiation. Kinetin / metabolism. Plant Growth Regulators / metabolism. Signal Transduction. Tobacco / metabolism

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  • (PMID = 16899291.001).
  • [ISSN] 0141-8130
  • [Journal-full-title] International journal of biological macromolecules
  • [ISO-abbreviation] Int. J. Biol. Macromol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Plant Growth Regulators; 7I6OOJ9GR6 / Zeatin; P39Y9652YJ / Kinetin
  • [Number-of-references] 118
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68. Kriuchkov AN, Freĭnd GG: [Age-related characteristics of breast invasive ductal carcinoma]. Arkh Patol; 2007 Nov-Dec;69(6):15-7
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  • 377 patients aged 30 to 79 years who had breast carcinoma were examined to study the age-related features of tumor anaplasia.
  • The degree of tumor anaplasia was studied, in primary nodules, less and more than 2.5 cm in diameter in patients of different ages.
  • This may explain more a malignant course of the disease in young patients.


69. Munirah S, Samsudin OC, Aminuddin BS, Ruszymah BH: Expansion of human articular chondrocytes and formation of tissue-engineered cartilage: a step towards exploring a potential use of matrix-induced cell therapy. Tissue Cell; 2010 Oct;42(5):282-92
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  • It has been well-documented that cell expansion is however accompanied by cellular dedifferentiation.
  • In order to promote cell growth and circumvent cellular dedifferentiation, we evaluated the effects of Transforming Growth Factor Beta-2 (TGF-β2), Insulin-like Growth Factor-I (IGF-I) and basic Fibroblast Growth Factor (bFGF) combination on articular chondrocytes culture and 'chondrocytes-fibrin' construct formation.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20810142.001).
  • [ISSN] 1532-3072
  • [Journal-full-title] Tissue & cell
  • [ISO-abbreviation] Tissue Cell
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Aggrecans; 0 / Collagen Type II; 0 / Culture Media; 0 / RNA, Messenger; 0 / SOX9 Transcription Factor; 0 / SOX9 protein, human; 0 / Transforming Growth Factor beta2; 103107-01-3 / Fibroblast Growth Factor 2; 67763-96-6 / Insulin-Like Growth Factor I; 9001-31-4 / Fibrin
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70. Boutet A, Esteban MA, Maxwell PH, Nieto MA: Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell Cycle; 2007 Mar 15;6(6):638-42
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  • Here we show that in dedifferentiated areas of human renal carcinomas, Snail undergoes a process of reactivation.

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  • (PMID = 17374993.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transcription Factors; 0 / snail family transcription factors
  • [Number-of-references] 42
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71. Halloran PF: T cell-mediated rejection of kidney transplants: a personal viewpoint. Am J Transplant; 2010 May;10(5):1126-34
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  • Local inflammation triggers dedifferentiation of the adjacent epithelium (e.g. loss of transporters and expression of embryonic genes) rather than cell death, via mechanisms that do not require known T-cell cytotoxic mechanisms or direct contact of T cells with the epithelium.
  • Local epithelial changes trigger a response of the entire nephron and a second wave of dedifferentiation.
  • The dedifferentiated epithelium is unable to exclude T cells, which enter to produce tubulitis lesions.
  • Thus TCMR is a cognate recognition-based process that creates local inflammation and epithelial dedifferentiation, stereotyped nephron responses, and tubulitis, and if untreated causes irreversible nephron loss.

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  • (PMID = 20346061.001).
  • [ISSN] 1600-6143
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 58
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72. Hirai T, Tokumo K, Tsuchiya D, Nishio H: Expression of mRNA for 5-HT2 receptors and proteins related to inactivation of 5-HT in mouse osteoblasts. J Pharmacol Sci; 2009 Feb;109(2):319-23
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  • The mRNA for the 5-HT(2A) receptor was detectable in anaplastic osteoblasts as well as in differentiated and matured osteoblasts.
  • The mRNA for the 5-HT(2B) receptor and 5-HT transporter was undetectable in anaplastic osteoblasts and became detectable in differentiated and matured osteoblasts.
  • It was suggested that 5-HT might regulate the proliferation of anaplastic osteoblasts through the 5-HT(2A) receptor without control by 5-HT-inactivating mechanisms.
  • The differentiation and maturation of osteoblasts might be regulated by the activation of the 5-HT(2B) receptor under the control of 5-HT inactivation.
  • [MeSH-minor] Anaplasia / genetics. Animals. Cell Differentiation / genetics. Cells, Cultured. Mice. RNA, Messenger / metabolism. Receptor, Serotonin, 5-HT2A / metabolism. Serotonin / genetics. Serotonin / metabolism

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  • (PMID = 19212095.001).
  • [ISSN] 1347-8613
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptor, Serotonin, 5-HT2A; 0 / Receptors, Serotonin, 5-HT2; 333DO1RDJY / Serotonin
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73. D'Agati VD: The spectrum of focal segmental glomerulosclerosis: new insights. Curr Opin Nephrol Hypertens; 2008 May;17(3):271-81
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  • PURPOSE OF REVIEW: Focal segmental glomerulosclerosis (FSGS) is a disease with diverse histologic patterns and etiologic associations.
  • In the collapsing variant, podocyte dysregulation leads to podocyte dedifferentiation and glomerular epithelial cell proliferation.
  • [MeSH-major] Cell Dedifferentiation. Cell Proliferation. Glomerulosclerosis, Focal Segmental / etiology. Podocytes / pathology

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  • (PMID = 18408478.001).
  • [ISSN] 1062-4821
  • [Journal-full-title] Current opinion in nephrology and hypertension
  • [ISO-abbreviation] Curr. Opin. Nephrol. Hypertens.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 103
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74. Decker L, Desmarquet-Trin-Dinh C, Taillebourg E, Ghislain J, Vallat JM, Charnay P: Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression. J Neurosci; 2006 Sep 20;26(38):9771-9
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  • Onset of myelination in Schwann cells is governed by several transcription factors, including Krox20/Egr2, and mutations affecting Krox20 result in various human hereditary peripheral neuropathies, including congenital hypomyelinating neuropathy (CHN) and Charcot-Marie-Tooth disease (CMT).
  • In the latter case, specific inactivation of Krox20 in adult Schwann cells results in severe demyelination, involving rapid Schwann cell dedifferentiation and increased proliferation, followed by an attempt to remyelinate and a block at the promyelinating stage.


75. Cabibi D, Cipolla C, Maria Florena A, Fricano S, Barresi E, Vieni S, Rodolico V, Napoli L: Solid variant of mammary "adenoid cystic carcinoma with basaloid features" merging with "small cell carcinoma". Pathol Res Pract; 2005;201(10):705-11
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  • Furthermore, positivity for CD10 was found both in sbACC and in SCC, supporting the hypothesis that the two components share the same histogenetic myoepithelial origin and represent an example of dedifferentiation along neuroendocrine phenotype lines occurring in a multipotential neoplastic stem line, already committed towards a myoepithelial phenotype.

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  • (PMID = 16325513.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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76. Uenotsuchi T, Imafuku S, Moroi Y, Urabe K, Furue M: Large subcutaneous liposarcoma arising from the chest wall. Eur J Dermatol; 2005 Jan-Feb;15(1):43-5
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  • We eventually diagnosed the tumor as a well-differentiated liposarcoma, adipocytic type (lipoma-like type).
  • Patients with cutaneous and subcutaneous liposarcoma have a good prognosis, but there are reports of local recurrence after a long period, as well as high-grade change and dedifferentiation.

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  • (PMID = 15701593.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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77. Mohan J, Bruce ME, Mabbott NA: Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin. Immunology; 2005 Feb;114(2):225-34
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  • [Title] Follicular dendritic cell dedifferentiation reduces scrapie susceptibility following inoculation via the skin.
  • Temporary dedifferentiation of follicular dendritic cells (FDCs) by treatment with an inhibitor of the lymphotoxin-beta receptor signalling pathway (LTbetaR-Ig) 3 days before or 14 days after inoculation via the skin, blocked the early accumulation of PrP(Sc) and TSE infectivity within the draining lymph node.
  • Furthermore, in the temporary absence of FDCs before inoculation, disease susceptibility was reduced and survival time significantly extended.
  • Treatment with LTbetaR-Ig 14 days after TSE inoculation also significantly extended the disease incubation period.
  • However, treatment 42 days after inoculation did not affect disease susceptibility or survival time, suggesting that the infection may have already have spread to the nervous system.
  • [MeSH-minor] Animals. Disease Susceptibility. Immunoblotting / methods. Immunoglobulin Fc Fragments / administration & dosage. Immunoglobulin G / administration & dosage. Injections. Lymph Nodes / chemistry. Lymphotoxin beta Receptor. Mice. Mice, Inbred BALB C. PrPSc Proteins / analysis. Receptors, Tumor Necrosis Factor / administration & dosage. Spleen / chemistry

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  • (PMID = 15667567.001).
  • [ISSN] 0019-2805
  • [Journal-full-title] Immunology
  • [ISO-abbreviation] Immunology
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BBS/E/I/00000989
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulin Fc Fragments; 0 / Immunoglobulin G; 0 / Ltbr protein, mouse; 0 / Lymphotoxin beta Receptor; 0 / PrPSc Proteins; 0 / Receptors, Tumor Necrosis Factor
  • [Other-IDs] NLM/ PMC1782078
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78. Gosset M, Berenbaum F, Thirion S, Jacques C: Primary culture and phenotyping of murine chondrocytes. Nat Protoc; 2008;3(8):1253-60
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  • The culture of chondrocytes is one of the most powerful tools for exploring the intracellular and molecular features of chondrocyte differentiation and activation.
  • However, chondrocytes tend to dedifferentiate into fibroblasts when they are subcultured, which is a major problem.
  • This protocol, involving primary cultures to limit dedifferentiation, describes two different methods for culturing chondrocytes of different anatomical origins (articular and costal chondrocytes, both of which represent hyaline cartilage) from mice.
  • [MeSH-minor] Animals. Cartilage / cytology. Cell Differentiation. Culture Media. Mice

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  • (PMID = 18714293.001).
  • [ISSN] 1750-2799
  • [Journal-full-title] Nature protocols
  • [ISO-abbreviation] Nat Protoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Culture Media
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79. Korzhevskiĭ DE, Lentsman MV, Giliarov AV, Kostkin VB, Otellin VA: [Morphological manifestations of astrocyte local functional activation produced by a short-term total brain ischemia]. Zh Evol Biokhim Fiziol; 2007 Sep-Oct;43(5):423-6
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  • The obtained data allow suggesting that the postischemic activation of astrocytes is accompanied by their acquistition of properties characteristic of immature cells of the nervous tissue; however, the absence of morphological signs of dedifferentiation does not permit these cells to be considered responsible for reparational neurogenesis in hippocampus.
  • [MeSH-minor] Animals. Cell Size. Disease Models, Animal. Immunohistochemistry. Male. Nestin. Rats. Rats, Sprague-Dawley

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  • (PMID = 18038640.001).
  • [ISSN] 0044-4529
  • [Journal-full-title] Zhurnal evoliutsionnoĭ biokhimii i fiziologii
  • [ISO-abbreviation] Zh. Evol. Biokhim. Fiziol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Intermediate Filament Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, rat; 0 / Nestin
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80. Zwickl H, Niculescu-Morzsa E, Nehrer S: Investigation of Collagen Transplants Seeded with Human Autologous Chondrocytes at the Time of Transplantation. Cartilage; 2010 Jul;1(3):194-9
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  • However, chondrocytes showed collagen I mRNA expression partially far exceeding that of collagen II, indicating a rather dedifferentiated cellular status.

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  • (PMID = 26069551.001).
  • [ISSN] 1947-6035
  • [Journal-full-title] Cartilage
  • [ISO-abbreviation] Cartilage
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4297067
  • [Keywords] NOTNLM ; articular cartilage / biomaterials / chondrocytes / repair / tissue engineering
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81. Sade S, Al Habeeb A, Ghazarian D: Spindle cell melanocytic lesions--part I: an approach to compound naevoidal pattern lesions with spindle cell morphology and Spitzoid pattern lesions. J Clin Pathol; 2010 Apr;63(4):296-321
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  • The presence of spindle cells may mask the melanocytic nature of a lesion, and is often disconcerting, either because of its infrequent appearance in a particular lesion or its interpretation as a dedifferentiated phenotype.
  • Spindle cell melanocytic lesions follow the full spectrum of potential biological outcomes, and difficulty may be experienced judging the nature of a lesion because of a lack of consistently reliable features to predict biological behaviour.
  • Over time, recognition of numerous histomorphological features that may portend a more aggressive lesion have been identified.
  • [MeSH-minor] Aged. Algorithms. Cell Differentiation. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Infant, Newborn. Male. Melanocytes / pathology. Melanoma / pathology. Middle Aged. Nevus, Pigmented / congenital. Nevus, Pigmented / pathology. Nevus, Spindle Cell / pathology

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  • (PMID = 20354202.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 122
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82. Eisner BH, McAleer SJ, Gargollo PC, Perez-Atayde A, Diamond DA, Elder JS: Pediatric penile tumors of mesenchymal origin. Urology; 2006 Dec;68(6):1327-30
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  • Immunohistochemical staining showed strong and diffuse CD34 cytoplasmic positivity in the giant cell fibroblastoma and dermatofibrosarcoma protuberans components; the dedifferentiated fibrosarcoma tumor cells were negative for this antibody.

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  • (PMID = 17169655.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Morikawa S, Mabuchi Y, Niibe K, Suzuki S, Nagoshi N, Sunabori T, Shimmura S, Nagai Y, Nakagawa T, Okano H, Matsuzaki Y: Development of mesenchymal stem cells partially originate from the neural crest. Biochem Biophys Res Commun; 2009 Feb 20;379(4):1114-9
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  • Previous studies reported that MSCs can differentiate to both mesodermal and neural lineages by a phenomenon referred to as ''dedifferentiation'' or ''transdifferentiation''.
  • EGFP-positive MSCs formed spheres that expressed neural crest stem cell genes and differentiated into neurons, glial cells, and myofibroblasts.
  • [MeSH-minor] Animals. Antigens, CD45 / analysis. Ataxin-1. Ataxins. Blood Group Antigens / analysis. Cell Differentiation. Clone Cells. Green Fluorescent Proteins / genetics. Mice. Mice, Transgenic. Nerve Tissue Proteins / analysis. Nuclear Proteins / analysis. Receptor, Platelet-Derived Growth Factor alpha / analysis

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  • (PMID = 19161980.001).
  • [ISSN] 1090-2104
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ataxin-1; 0 / Ataxins; 0 / Atxn1 protein, mouse; 0 / Blood Group Antigens; 0 / Nerve Tissue Proteins; 0 / Nuclear Proteins; 0 / TER-119 antigen, mouse; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 3.1.3.48 / Antigens, CD45
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84. Kogure T, Ueno Y, Sekiguchi S, Ishida K, Igarashi T, Wakui Y, Iwasaki T, Shimosegawa T: Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma. World J Gastroenterol; 2009 Mar 14;15(10):1267-72
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  • [Title] Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma.
  • However, radiological findings altered, which caused us to suspect that a well-differentiated hepatocellular carcinoma (HCC) containing fat was becoming dedifferentiated.
  • This case was an extremely rare LCA, which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.

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  • (PMID = 19291830.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA095817
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2658857
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85. Déglise S, Martin D, Probst H, Saucy F, Hayoz D, Waeber G, Nicod P, Ris HB, Corpataux JM, Haefliger JA: Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia. J Vasc Surg; 2005 Jun;41(6):1043-52
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  • The mechanisms involved in intimal hyperplasia are proliferation, dedifferentiation, and migration of medial smooth muscle cells towards the subintimal space.
  • We postulated that gap junctions, which coordinate physiologic processes such as cell growth and differentiation, might participate in the development of intimal hyperplasia.
  • In this model, the morphologic and functional integrity of the vessel wall is maintained and significant intimal hyperplasia development occurs after 14 days in culture.
  • We have postulated that gap junctions, which coordinate physiologic processes such as cell growth and differentiation, may participate in the development of intimal hyperplasia.
  • [MeSH-minor] Blotting, Western. Cell Differentiation. Cells, Cultured. Endothelial Cells / metabolism. Fatty Acids, Monounsaturated / pharmacology. Female. Humans. Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology. Hyperplasia. Indoles / pharmacology. Male. Middle Aged. Organ Culture Techniques. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 15944608.001).
  • [ISSN] 0741-5214
  • [Journal-full-title] Journal of vascular surgery
  • [ISO-abbreviation] J. Vasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Connexin 43; 0 / Fatty Acids, Monounsaturated; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / Indoles; 4L066368AS / fluvastatin
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91. Heebøll S, Borre M, Ottosen PD, Andersen CL, Mansilla F, Dyrskjøt L, Orntoft TF, Tørring N: SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation. Histol Histopathol; 2008 09;23(9):1069-76
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  • [Title] SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation.
  • In contrast, 20% of the specimens from patients with non-metastatic and non-recurrent disease showed moderate to marked staining.
  • In 31% of the patients with recurrent disease and in 31% of the patients with metastatic disease we found moderate to strong SMARCC1 immunostaining.
  • In a logistic regression analysis, patients with a marked SMARCC1 immunostaining had a significantly elevated odds ratio (OR) of 16 for recurrent cancer and an OR of 4.5 for metastatic disease.
  • Conclusions. Our present results demonstrate an increased expression of SMARCC1 protein in prostate cancer and reveal a positive correlation with tumour dedifferentiation, progression, metastasis and time to recurrence.
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. COS Cells. Cell Dedifferentiation. Cell Nucleus / metabolism. Cell Nucleus / pathology. Cercopithecus aethiops. Fluorescent Antibody Technique, Direct. Humans. Immunoenzyme Techniques. Lymph Nodes / metabolism. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local. Odds Ratio. Prostate / metabolism. Prostate / pathology. Prostatic Hyperplasia / metabolism. Prostatic Hyperplasia / pathology. Tissue Array Analysis. Up-Regulation

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  • (PMID = 18581278.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / SMARCC1 protein, human; 0 / Transcription Factors
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92. Jaskoll T, Abichaker G, Htet K, Bringas P Jr, Morita S, Sedghizadeh PP, Melnick M: Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs; 2010;192(4):221-39
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  • The aim of the present study was to examine the effects of CMV infection on progressive tooth differentiation and amelogenesis.
  • This viral-induced pathology is coincident with stage-dependent changes in Amelx, Enam and Dspp gene expression, distribution of amelogenin, enamelin and DSP proteins, cell proliferation localization and dedifferentiation of secretory ameloblasts.
  • [MeSH-minor] Ameloblasts / cytology. Amelogenesis Imperfecta / embryology. Amelogenesis Imperfecta / virology. Animals. Cell Dedifferentiation. Cell Differentiation. Cell Proliferation. Dental Enamel Hypoplasia / embryology. Dental Enamel Hypoplasia / virology. Dental Enamel Proteins / biosynthesis. Dental Enamel Proteins / genetics. Extracellular Matrix Proteins / biosynthesis. Extracellular Matrix Proteins / genetics. Gene Expression. Gene Expression Profiling. Mice. Odontoblasts / cytology. Phosphoproteins / biosynthesis. Phosphoproteins / genetics. Sialoglycoproteins / biosynthesis. Sialoglycoproteins / genetics. Tissue Culture Techniques

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20484882.001).
  • [ISSN] 1422-6421
  • [Journal-full-title] Cells, tissues, organs
  • [ISO-abbreviation] Cells Tissues Organs (Print)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Amelogenin; 0 / Amelx protein, mouse; 0 / Dental Enamel Proteins; 0 / Extracellular Matrix Proteins; 0 / Phosphoproteins; 0 / Sialoglycoproteins; 0 / dentin sialophosphoprotein; 0 / tuftelin
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93. Misra V, Singh P, Singh PA, Ahmad S: Cytodiagnosis of dedifferentiated liposarcoma clinically masquerading as a renal tumour. Cytopathology; 2009 Jun;20(3):195-8
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  • [Title] Cytodiagnosis of dedifferentiated liposarcoma clinically masquerading as a renal tumour.

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  • (PMID = 18627405.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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94. Serpell JW, Chen RY: Review of large deep lipomatous tumours. ANZ J Surg; 2007 Jul;77(7):524-9
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  • There are controversies regarding the histopathological diagnosis, nomenclature, diagnostic method, surgical management, roles of radiotherapy and the risk of metastasis, local recurrence and dedifferentiation.
  • RESULTS: Eleven deep lipomas, six deep atypical lipomas, four well-differentiated (lipoma-like) liposarcomas, three well-differentiated liposarcomas and four liposarcomas were studied.
  • Dedifferentiation occurred in one deep atypical lipoma, which transformed into a liposarcoma.
  • Key aspects in achieving a complete, but marginal resection of the deep atypical lipoma and the well-differentiated lipoma-like liposarcoma is accurate preoperative diagnosis with core biopsy and accurate imaging to assess deep unsuspected extensions of the tumour.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Differentiation. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Retrospective Studies. Tomography, X-Ray Computed

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  • [CommentIn] ANZ J Surg. 2007 Dec;77(12):1129 [17973678.001]
  • (PMID = 17610686.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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95. Prasad CK, Muraleedharan CV, Krishnan LK: Bio-mimetic composite matrix that promotes endothelial cell growth for modification of biomaterial surface. J Biomed Mater Res A; 2007 Mar 1;80(3):644-54
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  • In this study, assessment of the same matrix to prevent EC from dedifferentiation during in vitro culture and to promote endothelialization of biomaterials used for fabrication of cardiovascular implants is carried out.
  • Up/down regulation of m-RNA expression for a prothrombotic molecule-plasminogen activator inhibitor (PAI), and two antithrombotic molecules- nitric oxide synthetase (eNOS) and tissue plasminogen activator (t-PA) are chosen as the indicators of cell dedifferentiation during cell culture and passaging.

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  • (PMID = 17051537.001).
  • [ISSN] 1549-3296
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Plasminogen Activator Inhibitor 1; EC 1.14.13.39 / Nitric Oxide Synthase Type III; EC 3.4.21.68 / Tissue Plasminogen Activator
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96. Jiang Q, Huang R, Cai S, Wang CL: Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability. J Biomed Sci; 2010 Feb 03;17:6
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  • CONCLUSIONS: These results suggest that both the expression level and the level of MAPK- and/or PAK-mediated phosphorylation of CaD play key roles in regulating the cell motility by modulating the actin cytoskeleton stability in dedifferentiated vascular SMCs such as A7r5.

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  • (PMID = 20128924.001).
  • [ISSN] 1423-0127
  • [Journal-full-title] Journal of biomedical science
  • [ISO-abbreviation] J. Biomed. Sci.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL092252; United States / NHLBI NIH HHS / HL / R01 HL92252
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Calmodulin-Binding Proteins; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins
  • [Other-IDs] NLM/ PMC2846900
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97. Schumann D, Kujat R, Nerlich M, Angele P: Mechanobiological conditioning of stem cells for cartilage tissue engineering. Biomed Mater Eng; 2006;16(4 Suppl):S37-52
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  • Articular cartilage possesses little capacity for endogenous repair after having been damaged by disease or trauma.
  • Numerous publications show the beneficial influence of mechanobiological conditioning (e.g. mechanical compression, hydrostatic pressure, osmotic, shear, ultrasound) on the chondrogenic differentiation of dedifferentiated chondrocytes.
  • Similar results, with an increase in chondrogenic differentiation of mesenchymal progenitor cells could be detected, when the cells were loaded in three-dimensional matrices and subjected to cyclic, compressive load or low-intensity pulsed ultrasound.

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  • (PMID = 16823112.001).
  • [ISSN] 0959-2989
  • [Journal-full-title] Bio-medical materials and engineering
  • [ISO-abbreviation] Biomed Mater Eng
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 172
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98. Lee YA, Kang SS, Baek SH, Jung JC, Jin EJ, Tak EN, Sonn JK: Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase. Mol Cells; 2007 Aug 31;24(1):9-15
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  • [Title] Redifferentiation of dedifferentiated chondrocytes on chitosan membranes and involvement of PKCalpha and P38 MAP kinase.
  • To investigate the effects of chitosan on the redifferentiation of dedifferentiated chondrocytes, we used chondrocytes obtained from a micromass culture system.
  • Micromass cultures of chick wing bud mesenchymal cells yielded differentiated chondrocytes, but these dedifferentiated during serial monolayer subculture.
  • When the dedifferentiated chondrocytes were cultured on chitosan membranes they regained the phenotype of differentiated chondrocytes.
  • Expression of protein kinase C (PKC) increased during chondrogenesis, decreased during dedifferentiation, and increased again during redifferentiation.
  • These findings establish a culture system for producing chondrocytes, point to a new role of chitosan in the redifferentiation of dedifferentiated chondrocytes, and show that PKC and p38 MAP kinase activities are required for chondrocyte redifferentiation in this model system.
  • [MeSH-major] Cell Differentiation / physiology. Chondrocytes / physiology. Protein Kinase C-alpha / physiology. p38 Mitogen-Activated Protein Kinases / physiology

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  • (PMID = 17846494.001).
  • [ISSN] 1016-8478
  • [Journal-full-title] Molecules and cells
  • [ISO-abbreviation] Mol. Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 9012-76-4 / Chitosan; EC 2.7.11.13 / Protein Kinase C-alpha; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; NI40JAQ945 / Tetradecanoylphorbol Acetate
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99. Park K, Min BH, Han DK, Hasty K: Quantitative analysis of temporal and spatial variations of chondrocyte behavior in engineered cartilage during long-term culture. Ann Biomed Eng; 2007 Mar;35(3):419-28
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  • The gene expression ratio of collagen type II to I appeared to be more altered in the periphery, possibly suggesting cell dedifferentiation, especially at later time points (>2 weeks).
  • This study showed that chondrocyte behavior could be highly variable in the extent of their proliferation, differentiation and dedifferentiation, depending on their physical location within 3D engineered cartilage construct.

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  • (PMID = 17151924.001).
  • [ISSN] 0090-6964
  • [Journal-full-title] Annals of biomedical engineering
  • [ISO-abbreviation] Ann Biomed Eng
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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100. Costa Martínez E, Rodríguez Hernández JC, Machado M, Mano JF, Gómez Ribelles JL, Monleón Pradas M, Salmerón Sánchez M: Human chondrocyte morphology, its dedifferentiation, and fibronectin conformation on different PLLA microtopographies. Tissue Eng Part A; 2008 Oct;14(10):1751-62
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  • [Title] Human chondrocyte morphology, its dedifferentiation, and fibronectin conformation on different PLLA microtopographies.
  • [MeSH-minor] Actins / metabolism. Cell Differentiation. Humans. Microfilament Proteins / metabolism. Microscopy, Atomic Force. Microscopy, Electron, Scanning. Protein Conformation. Tissue Engineering / methods

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  • (PMID = 18823278.001).
  • [ISSN] 1937-3341
  • [Journal-full-title] Tissue engineering. Part A
  • [ISO-abbreviation] Tissue Eng Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Biocompatible Materials; 0 / Fibronectins; 0 / Microfilament Proteins; 0 / Polymers; 0 / tensins; 33X04XA5AT / Lactic Acid
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