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1. Stearns D, Chaudhry A, Abel TW, Burger PC, Dang CV, Eberhart CG: c-myc overexpression causes anaplasia in medulloblastoma. Cancer Res; 2006 Jan 15;66(2):673-81
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  • [Title] c-myc overexpression causes anaplasia in medulloblastoma.
  • Both anaplasia and increased c-myc gene expression have been shown to be negative prognostic indicators for survival in medulloblastoma patients. myc gene amplification has been identified in many large cell/anaplastic medulloblastoma, but no causative link between c-myc and anaplastic changes has been established.
  • Most remarkably, the histopathology of the Myc tumors was severely anaplastic, with large areas of necrosis/apoptosis, increased nuclear size, and macronucleoli.
  • Thus, c-myc seems to play a causal role in inducing anaplasia in medulloblastoma.
  • Because anaplastic changes are often observed in recurrent medulloblastoma, we propose that c-myc dysregulation is involved in the progression of these malignant embryonal neoplasms.
  • [MeSH-minor] Anaplasia. Animals. Apoptosis. Cell Proliferation. Humans. Mice. Necrosis. Transplantation, Heterologous. Tumor Cells, Cultured

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  • (PMID = 16423996.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS 43279; United States / NCI NIH HHS / CA / T32 CA 009574
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MYC protein, human; 0 / Proto-Oncogene Proteins c-myc
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2. Qualman S, Lynch J, Bridge J, Parham D, Teot L, Meyer W, Pappo A: Prevalence and clinical impact of anaplasia in childhood rhabdomyosarcoma : a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. Cancer; 2008 Dec 1;113(11):3242-7
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  • [Title] Prevalence and clinical impact of anaplasia in childhood rhabdomyosarcoma : a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.
  • A recent review of cases from the Soft Tissue Sarcoma Committee of the Children's Oncology Group (COG) suggests that anaplasia might be more common than previously reported and may impact clinical outcome.
  • METHODS: The prevalence of anaplasia (focal or diffuse) was prospectively assessed in 546 eligible cases who were registered in an Intergroup Rhabdomyosarcoma Study Group (IRSG) or COG therapeutic trial from 1995 through 1998.
  • The incidence of anaplasia in tumor samples and its impact in predicting clinical outcome was assessed.
  • RESULTS: Overall, 71 (13%) of all samples analyzed had anaplasia.
  • Anaplasia was more common in patients with tumors in favorable sites and was less commonly observed in younger patients and in those with stage II, III, or clinical group III disease.
  • Regardless of its distribution (focal or diffuse), on univariate analysis the presence of anaplasia negatively influenced the failure-free survival rate (63% vs 77% at 5 years) and overall survival (68% vs 82% at 5 years) rates in patients with embryonal rhabdomyosarcoma.
  • Anaplasia did not affect outcome in patients with alveolar tumors.
  • CONCLUSIONS: The incidence of anaplasia in patients with rhabdomyosarcoma is higher than previously described and may be of prognostic significance in children with intermediate-risk embryonal rhabdomyosarcoma.

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  • [Copyright] (c) 2008 American Cancer Society
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  • [ErratumIn] Cancer. 2009 Jun 15;115(12):2806
  • (PMID = 18985676.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA098543-06; United States / NCI NIH HHS / CA / U10 CA098413-06; United States / NCI NIH HHS / CA / U10 CA098413; None / None / / U10 CA024507-25; United States / NCI NIH HHS / CA / U10 CA024507-26; United States / NCI NIH HHS / CA / U10 CA098543; None / None / / U10 CA098413-06; None / None / / U10 CA024507-26; United States / NCI NIH HHS / CA / U10 CA024507-25; None / None / / U10 CA098543-06; United States / NCI NIH HHS / CA / U10 CA024507
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS107192; NLM/ PMC2727712
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3. Rodriguez FJ, Eberhart C, O'Neill BP, Slezak J, Burger PC, Goldthwaite P, Wu W, Giannini C: Histopathologic grading of adult medulloblastomas. Cancer; 2007 Jun 15;109(12):2557-65
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  • BACKGROUND: Histopathologic evaluation of the degree and extent of anaplasia is a useful prognostic parameter in pediatric medulloblastomas.
  • METHODS: The study included 74 adult patients with histologically confirmed medulloblastomas and retrospectively reassessed 67 cases with available slides for the presence of nodularity, collagen deposition (desmoplasia without nodules), and degree and extent of anaplasia.
  • Anaplasia was absent (34%), mild (34%), moderate (27%), or severe (5%).
  • Severe anaplasia was diffuse in 2 cases and focal in 1, although in the latter cases severe anaplasia was diffusely present at the time of disease recurrence.
  • Severe anaplasia at first resection was found to be an independent predictor of decreased recurrence-free survival (P = .005) and overall survival (P = .015).
  • CONCLUSIONS: The incidence of severe anaplasia in adult medulloblastomas is lower than in the pediatric population.
  • Male sex and the presence of severe anaplasia at the time of first resection are predictors of decreased recurrence-free and overall survival.
  • However, the significance of severe anaplasia should be regarded with caution based on the small number of tumors with this feature in the current study.

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  • [Copyright] Copyright 2007 American Cancer Society.
  • (PMID = 17487854.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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4. Work TM, Aeby GS, Coles SL: Distribution and morphology of growth anomalies in Acropora from the Indo-Pacific. Dis Aquat Organ; 2008 Jan 24;78(3):255-64
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  • There was no evidence of anaplasia or mitotic figures (common but not necessarily required morphologic indicators of neoplasia).
  • The evidence of GAs being true neoplasias (tumors) is mixed, so a cautionary approach is urged in use of morphologic terminology.

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  • (PMID = 18380225.001).
  • [ISSN] 0177-5103
  • [Journal-full-title] Diseases of aquatic organisms
  • [ISO-abbreviation] Dis. Aquat. Org.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
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5. Tsuruga Y, Kiyono T, Matsushita M, Takahashi T, Kasai H, Todo S: Establishment of Immortalized Human Hepatocytes by Introduction of HPV16 E6/E7 and hTERT as Cell Sources for Liver Cell-Based Therapy. Cell Transplant; 2008 Sep;17(9):1083-1094
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  • Intrasplenic transplantation of dedifferentiated HHE6E7T-1 cells over 200 PDs significantly improved the survival of acetaminophen-induced acute liver failure SCID mice.
  • In conclusion, we successfully established immortalized human hepatocytes that retain the characteristics of differentiated hepatocytes.

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  • (PMID = 28863749.001).
  • [ISSN] 1555-3892
  • [Journal-full-title] Cell transplantation
  • [ISO-abbreviation] Cell Transplant
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Acetaminophen-induced acute liver failure / Chromosomal instability / Dedifferentiation / Hepatocyte transplantation / Tumorigenicity
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6. Smith C, Santi M, Rajan B, Rushing EJ, Choi MR, Rood BR, Cornelison R, MacDonald TJ, Vukmanovic S: A novel role of HLA class I in the pathology of medulloblastoma. J Transl Med; 2009;7:59
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  • Medulloblastomas expressing high levels of HLA class I displayed significantly higher levels of anaplasia and c-myc expression, markers of poor prognosis.
  • CONCLUSION: MHC class I expression in medulloblastoma is associated with anaplasia and c-myc expression, markers of poor prognosis.
  • [MeSH-minor] Anaplasia / pathology. Antigens, CD45 / metabolism. Cell Line, Tumor. Enzyme Activation. Extracellular Signal-Regulated MAP Kinases / metabolism. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Prognosis. Proto-Oncogene Proteins c-myc / metabolism

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  • (PMID = 19594892.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA111835; United States / NCI NIH HHS / CA / R01 CA111835
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Histocompatibility Antigens Class I; 0 / Proto-Oncogene Proteins c-myc; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.1.3.48 / Antigens, CD45
  • [Other-IDs] NLM/ PMC2714836
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7. Delorme S, Weber MA: Applications of MRS in the evaluation of focal malignant brain lesions. Cancer Imaging; 2006;6:95-9
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  • Generally, an increased concentration of choline is found in all primary and secondary brain tumors, and the degree of increase correlates with the degree of anaplasia.
  • Further indicators of anaplasia are the presence of lactate, indicating hypoxia, and of fatty acids, indicating necrosis.
  • Today, proton spectroscopy is clearly indicated for differentiating radiation-induced damage from recurrences of irradiated brain tumors.

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  • (PMID = 16829470.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1693767
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8. Grabois MF, Mendonça GA: [Prognosis for patients with unilateral Wilms' tumor in Rio de Janeiro, Brazil, 1990-2000]. Rev Saude Publica; 2005 Oct;39(5):731-7
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  • [Title] [Prognosis for patients with unilateral Wilms' tumor in Rio de Janeiro, Brazil, 1990-2000].
  • [Transliterated title] Prognóstico de pacientes com tumor de Wilms unilateral no Rio de Janeiro, 1990-2000.
  • The survival probabilities for disease in stages I, II, III and IV stages were: 100%, 94.2%, 83.2% and 31.3%, respectively.
  • The survival rate was 89.4% for patients with favorable histology, 66.7% for focal anaplasia and 40% for diffuse anaplasia.
  • All patients with stage IV disease and diffuse anaplasia died (n=4).
  • All patients with stage I disease, regardless of histology, remained alive at the end of the follow-up period.

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  • (PMID = 16254648.001).
  • [ISSN] 0034-8910
  • [Journal-full-title] Revista de saúde pública
  • [ISO-abbreviation] Rev Saude Publica
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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9. Hamilton TE, Green DM, Perlman EJ, Argani P, Grundy P, Ritchey ML, Shamberger RC: Bilateral Wilms' tumor with anaplasia: lessons from the National Wilms' Tumor Study. J Pediatr Surg; 2006 Oct;41(10):1641-4
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  • [Title] Bilateral Wilms' tumor with anaplasia: lessons from the National Wilms' Tumor Study.
  • PURPOSE: The purpose of this study was to evaluate whether initial diagnostic technique influenced the ability to identify anaplastic histology, to determine the time interval to diagnosis of anaplasia, and to delineate the incidence of discordant pathology in bilateral Wilms' tumor.
  • We hypothesized that delay in diagnosis of anaplasia could affect time to appropriate surgery and intensive multimodality therapy.
  • METHODS: One hundred eight-nine children were enrolled in the fourth National Wilms' Tumor Study with synchronous bilateral tumors, 27 of whom were eventually shown to have anaplastic histology.
  • Initial diagnostic technique, time interval to diagnosis of anaplasia, and the incidence of discordant pathology were determined.
  • RESULTS: Anaplasia was identified in 0 of 7 tumors by core needle biopsy, 3 of 9 tumors by open wedge biopsy, and in 7 of 9 cases by partial or complete nephrectomy.
  • The mean duration of first chemotherapy regimen (DD or EE) was 20, 39, and 36 weeks, respectively, before anaplasia was identified at second surgery.
  • Only 4 patients had anaplastic tumors in both kidneys.
  • CONCLUSIONS: Core needle biopsy did not identify anaplasia in 7 of 7 children.
  • Open biopsy or partial/complete nephrectomy identified anaplasia at initial diagnostic procedure in 10 of 18 children.
  • Earlier interval incisional biopsy or resection may identify anaplastic histology and limit the duration of chemotherapy targeted to favorable histology for children with bilateral Wilms' tumor and anaplasia.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anaplasia. Antineoplastic Agents / therapeutic use. Biopsy. Biopsy, Needle. Female. Humans. Kidney / pathology. Male. Middle Aged. Nephrectomy. Reoperation

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  • (PMID = 17011261.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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10. Li W, Kessler P, Williams BR: Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia. Oncogene; 2005 Jan 13;24(3):457-68
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  • [Title] Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia.
  • Anaplasia (unfavorable histology) is associated with therapy resistance and poor prognosis of Wilms tumor, but the molecular basis for this phenotype is unclear.
  • By linking genes differentially expressed between fetal kidney and Wilms tumors to kidney morphogenesis, we found that genes expressed at a higher level in Wilms tumors tend to be expressed more in uninduced metanephrogenic mesenchyme or blastema than in their differentiated structures.
  • We also identified 97 clones representing 76 Unigenes or unclustered ESTs that clearly separate anaplastic Wilms tumors from tumors with favorable histology.
  • Genes in this set provide insight into the nature of the abnormal nuclear morphology of anaplastic tumors and may facilitate identification of molecular targets to improve their responsiveness to treatment.

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  • (PMID = 15531917.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA89279
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
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11. Giordana MT, D'Agostino C, Pollo B, Silvani A, Ferracini R, Paiolo A, Ghiglione P, Chiò A: Anaplasia is rare and does not influence prognosis in adult medulloblastoma. J Neuropathol Exp Neurol; 2005 Oct;64(10):869-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplasia is rare and does not influence prognosis in adult medulloblastoma.
  • Histopathologic grading based on increasing anaplasia predicts clinical behavior of pediatric medulloblastomas.
  • The present study was aimed at grading 86 medulloblastomas of adult patients (aged 18 and older) by anaplasia and analyzing the predictive power.
  • [MeSH-minor] Adult. Aged. Anaplasia. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 16215458.001).
  • [ISSN] 0022-3069
  • [Journal-full-title] Journal of neuropathology and experimental neurology
  • [ISO-abbreviation] J. Neuropathol. Exp. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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12. Glavatskiĭ AIa, Guzhovskaia NV, Lysenko SN, Kulik AV: [Methods of statistical analysis in differential diagnostics of the degree of brain glioma anaplasia during preoperative stage]. Lik Sprava; 2005 Dec;(8):53-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Methods of statistical analysis in differential diagnostics of the degree of brain glioma anaplasia during preoperative stage].
  • The authors proposed a possible preoperative diagnostics of the degree of supratentorial brain gliom anaplasia using statistical analysis methods.
  • It relies on a complex examination of 934 patients with I-IV degree anaplasias, which had been treated in the Institute of Neurosurgery from 1990 to 2004.
  • The use of statistical analysis methods for differential diagnostics of the degree of brain gliom anaplasia may optimize a diagnostic algorithm, increase reliability of obtained data and in some cases avoid carrying out irrational operative intrusions.
  • Clinically important signs for the use of statistical analysis methods directed to preoperative diagnostics of brain gliom anaplasia have been defined

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  • (PMID = 16498785.001).
  • [ISSN] 1019-5297
  • [Journal-full-title] Likars'ka sprava
  • [ISO-abbreviation] Lik. Sprava
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
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13. Ambrosino G, Basso SMM, Varotto S, Zardi E, Picardi A, D'amico DF: Isolated Hepatocytes versus Hepatocyte Spheroids: In Vitro Culture of Rat Hepatocytes. Cell Transplant; 2005 Jul;14(6):397-401

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Unfortunately, the loss of specialized liver functions (dedifferentiation) is still a major problem.

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  • (PMID = 28876103.001).
  • [ISSN] 1555-3892
  • [Journal-full-title] Cell transplantation
  • [ISO-abbreviation] Cell Transplant
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Albumin / Benzodiazepine / Culture / Hepatocyte spheroids / Isolation / Matrix
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14. Rossi S, Rodriguez FJ, Mota RA, Dei Tos AP, Di Paola F, Bendini M, Agostini S, Longatti P, Jenkins RB, Giannini C: Primary leptomeningeal oligodendroglioma with documented progression to anaplasia and t(1;19)(q10;p10) in a child. Acta Neuropathol; 2009 Oct;118(4):575-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary leptomeningeal oligodendroglioma with documented progression to anaplasia and t(1;19)(q10;p10) in a child.
  • [MeSH-minor] Anaplasia / genetics. Anaplasia / pathology. Child, Preschool. Chromosome Deletion. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Translocation, Genetic

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  • (PMID = 19562354.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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15. Garami Z, Benkó K, Kósa C, Fülöp B, Lukács G: [The effect of mammographic screening on tumor size, axillary node status and the degree of histologic anaplasia]. Magy Seb; 2006 Oct;59(5):383-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The effect of mammographic screening on tumor size, axillary node status and the degree of histologic anaplasia].
  • Of the histopathological data of 633 patients operated with primary breast tumor at the 1st Surgical Clinic of the Debrecen Medical University between January 1st 2000 and December 31st 2004, the authors analyzed tumor diameter, axillary node status and the degree of histologic anaplasia and compared them with the data of mammographic screening.
  • A study of the degree of histologic anaplasia showed G-I tumors in 15.6%, G-IIs in 62.1% and G-IIIs in 22.3% of the "screened" patients.
  • [MeSH-minor] Adult. Aged. Anaplasia / diagnosis. Axilla. Female. Humans. Hungary / epidemiology. Lymphatic Metastasis. Middle Aged. Neoplasm Staging. Retrospective Studies

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  • (PMID = 17201347.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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16. Suzuki T, Murata S, Yamaguchi H, Shimizu Y, Shimizu M: Epithelial-myoepithelial carcinoma with myoepithelial anaplasia: report of a case with cytologic findings of a rare variant. Acta Cytol; 2010 Jul-Aug;54(4):605-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial-myoepithelial carcinoma with myoepithelial anaplasia: report of a case with cytologic findings of a rare variant.
  • Rare aggressive variants of EMC, dedifferentiated EMC and EMC with myoepithelial anaplasia have been reported.
  • CASE: An 81-year-old man presented with EMC of the parotid gland showing the classical type at the time of initial presentation and a high grade type with myoepithelial anaplasia at recurrence after 10 years.
  • CONCLUSION: The cytologic findings of the recurrent tumor were consistent with a rare variant of EMC with myoepithelial anaplasia.
  • To the best of our knowledge, this is the first report of the cytologic finding of an EMC with myoepithelial anaplasia.

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  • (PMID = 20715665.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucin-1
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17. Spreafico F, Piva L, D'Angelo P, Terenziani M, Collini P, Gandola L, Bianchi M, Tamburini A, Provenzi M, Fossati Bellani F: Are all stage III Wilms tumors the same? Data from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). J Clin Oncol; 2009 May 20;27(15_suppl):10030

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • 7 patients had intensified chemotherapy/RT for diffuse anaplasia.
  • Overall 16 tumor failure occurred (2 in anaplastic tumors): abdominal relapse 8 (combined to other extra-abdominal site 3), lung 5, tumor progression 2, metacronous tumor 1.

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  • (PMID = 27962574.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Paner GP, McKenney JK, Epstein JI, Amin MB: Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma. Am J Surg Pathol; 2008 Jul;32(7):1022-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma.
  • We report the clinicopathologic features of 5 bladder neoplasms with rhabdomyosarcomatous differentiation in adults and emphasize the differential diagnosis in the adult setting.
  • Gross hematuria was the most common initial symptom, although 2 patients had metastatic disease at presentation.
  • All 5 cases demonstrated a diffuse growth pattern (ie, non-nested), of which 4 cases had nuclear anaplasia (Wilms criteria without the atypical mitotic figure requirement); only 1 case (the sarcomatoid carcinoma) showed obvious rhabdomyoblastic differentiation (ie, strap cells).
  • The degree of morphologic overlap with small cell carcinoma of the bladder, a relatively more common round cell tumor in adults, was striking.
  • The epithelial component of the sarcomatoid carcinoma was high-grade invasive urothelial carcinoma with glandular differentiation.
  • Outcome data were available in 4 cases, and all 4 died of disease (1, 4, 8, and 8 mo).
  • In conclusion, (1) RMS of the urinary bladder in adults more commonly presents as a primitive round blue cell neoplasm that has significant morphologic and immunohistochemical overlap with small cell carcinoma of the bladder. (2) Although RMS in children generally have a botryoid embryonal histology with favorable outcome, bladder RMS in adults frequently demonstrates alveolar or unclassified histology, commonly with anaplasia, and have a uniformly aggressive clinical course.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anaplasia. Biomarkers, Tumor / analysis. Cell Nucleus / pathology. Combined Modality Therapy. Desmin / analysis. Diagnosis, Differential. Fatal Outcome. Female. Humans. Male. Middle Aged. MyoD Protein / analysis. Myogenin / analysis. Synaptophysin / analysis

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  • (PMID = 18469707.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmin; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / Myogenin; 0 / Synaptophysin
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19. Wittmann S, Zirn B, Alkassar M, Ambros P, Graf N, Gessler M: Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis. Genes Chromosomes Cancer; 2007 Feb;46(2):163-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis.
  • Evaluation of LOH with respect to clinical data revealed significant associations of LOH 11q with histology: LOH 11q was 3-4 times more frequent in mixed type and diffuse anaplastic tumors.
  • [MeSH-major] Anaplasia / genetics. Chromosome Deletion. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 16. Neoplasm Recurrence, Local / genetics. Wilms Tumor / genetics

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 17099873.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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20. Kriuchkov AN, Freĭnd GG: [Age-related characteristics of breast invasive ductal carcinoma]. Arkh Patol; 2007 Nov-Dec;69(6):15-7
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  • 377 patients aged 30 to 79 years who had breast carcinoma were examined to study the age-related features of tumor anaplasia.
  • The degree of tumor anaplasia was studied, in primary nodules, less and more than 2.5 cm in diameter in patients of different ages.
  • This may explain more a malignant course of the disease in young patients.

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  • (PMID = 18290373.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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21. Matsko DE, Vogel G, Ulitin AIu, Oliushin VE, Moes G, Pergamenshchikov AA, Burnin KS, Safarov BI, Markova NV: [Invasive giant pituitary adenomas]. Arkh Patol; 2007 Mar-Apr;69(2):46-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Invasive growth of adenomas was related to neither the structure of the tumor, the degree of anaplasia, or the nature of a generated hormone.

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  • (PMID = 17642195.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CAM 5.2 antigen; 68238-35-7 / Keratins
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22. Taran K, Kobos J, Sporny S: Number of mitotic figures in microscopic picture of nephroblastoma histologic types--estimation of the value of the oldest known prognostic factor. Pol J Pathol; 2008;59(1):43-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There are two main widely accepted prognostic factors in nephroblastoma group of tumors--histological type of tumor and clinical stage of disease.
  • However nuclear anaplasia, one of the elements of Wilms' tumor microscopic picture was found as a new prognostic marker in this group of tumors.
  • Estimation of nuclear anaplasia is an obligatory procedure in currently used therapeutic protocols.
  • In our work we compared another element of nephroblastoma microscopic picture--number of mitoses as the oldest known indicator of activity of tumor cells with prognostic markers estimated in routine histologic examination according SIOP Protocols (histological risk, nephroblastoma type and the presence of diffuse anaplasia) and with CD44 expression--widely known marker of discussed prognostic value.

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  • (PMID = 18655370.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
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23. Meng RD, Qin L, Shelton CC, Li Y, Maki RG, Brill ER, Singer S, Schwartz GK: Association of Notch signaling pathway expression in liposarcomas with outcome, and targeting with gamma-secretase inhibitors. J Clin Oncol; 2009 May 20;27(15_suppl):10526

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: RNA was isolated from 18 normal fat and 140 LPS tissue samples from five LPS subtypes: well-differentiated (33%), de-differentiated DD (25%), myxoid (12%), round cell (6%), and pleomorphic (13%), and were hybridized to Affymetrix U133A arrays.

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  • (PMID = 27963915.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Ferrari S, Smeland S, Bielack S, Comandone A, Dileo P, Picci P, Sundby Hall K, Eriksson M, Honegger H, Reichardt P: A European treatment protocol for bone sarcoma in patients older than 40 years. J Clin Oncol; 2009 May 20;27(15_suppl):10516

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Patients with HG Osteosarcoma (OS), HG sarcoma NOS (S), Fibrosarcoma, MFH, Leiomyosarcoma, Dedifferentiated Chondrosarcoma (DCh) were included.
  • Osteosarcoma and high-grade sarcoma NOS benefit from chemotherapy more than patients with dedifferentiated chondrosarcoma.

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  • (PMID = 27963653.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Giangaspero F, Wellek S, Masuoka J, Gessi M, Kleihues P, Ohgaki H: Stratification of medulloblastoma on the basis of histopathological grading. Acta Neuropathol; 2006 Jul;112(1):5-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Relapse free survival for medulloblastomas with severe anaplasia [5-year rate: S(60)=49.5%], was significantly shorter than for tumours with moderate or mild anaplasia S(60)=65.4%; P=0.001).
  • These findings indicate that degree of anaplasia is the most significant histologic feature predictive of the survival of medulloblastoma patients.
  • [MeSH-minor] Adolescent. Anaplasia / pathology. Apoptosis / physiology. Biomarkers, Tumor / genetics. Child. Child, Preschool. Clinical Trials as Topic. Female. Humans. Male. Mutation. Necrosis / pathology. Polymerase Chain Reaction. Polymorphism, Single-Stranded Conformational. Survival Rate. beta Catenin / genetics

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  • (PMID = 16685513.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / beta Catenin
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26. Korshunov A, Benner A, Remke M, Lichter P, von Deimling A, Pfister S: Accumulation of genomic aberrations during clinical progression of medulloblastoma. Acta Neuropathol; 2008 Oct;116(4):383-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of 16 tumors showing early recurrence (<4 years after first diagnosis), only one showed increased histological anaplasia in the secondary lesion (6%), and two acquired genomic lesions indicative for a more malignant phenotype (13%).
  • In contrast to this, of 12 tumors with a time to recurrence of 4 years or more, nine tumors (75%) showed a more malignant phenotype either reflected by increased anaplasia alone or by both increased anaplasia and acquirement of genomic aberrations known to be associated with inferior patient outcome.
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Child. Child, Preschool. Cytogenetic Analysis. Disease Progression. Female. Humans. Male. Neoplasm Recurrence, Local / genetics. Prognosis

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  • (PMID = 18704466.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MYC protein, human; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins; 0 / Proto-Oncogene Proteins c-myc
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27. Perk J, Iavarone A, Benezra R: Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer; 2005 08;5(8):603-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this review is to analyze the potential role of the inhibitor of DNA binding (Id) proteins in cancer and examine whether deregulated Id activity is tumorigenic and contributes to hallmarks of malignancy, such as loss of differentiation (anaplasia), unrestricted proliferation and neoangiogenesis.
  • [MeSH-minor] Anaplasia / physiopathology. Cell Proliferation. Humans. Inhibitor of Differentiation Protein 1. Models, Animal. Neovascularization, Pathologic / physiopathology

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  • [ErratumIn] Nat Rev Cancer. 2005 Sep;5(9):750
  • (PMID = 16034366.001).
  • [ISSN] 1474-175X
  • [Journal-full-title] Nature reviews. Cancer
  • [ISO-abbreviation] Nat. Rev. Cancer
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ID1 protein, human; 0 / Inhibitor of Differentiation Protein 1; 0 / Repressor Proteins; 0 / Transcription Factors
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28. Adam C, Polivka M, Carpentier A, George B, Gray F: Papillary glioneuronal tumor: not always a benign tumor? Clin Neuropathol; 2007 May-Jun;26(3):119-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report two additional cases: a clinically, radiologically and histopathologically typical tumor in a 38-year-old man and an atypical tumor with histopathological features of anaplasia in a 74-year-old woman.
  • The latter tumor showed the classical pseudopapillary pattern with ganglioid cells and some astrocytes between the papillae, but also had changes suggestive of anaplasia including necrosis, capillary endothelial proliferation, mitoses, dedifferentiation with loss of GFAP expression of the cuboidal cells and increased Ki-67 labeling of over 10%.
  • Our cases indicate that PGNT type of ganglioglioma can have a spectrum of anaplastic changes of higher grade.

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  • (PMID = 19157003.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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29. Wu HT, Allie N, Myer L, Govender D: Anaplastic nephroblastomas express transketolase-like enzyme 1. J Clin Pathol; 2009 May;62(5):460-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic nephroblastomas express transketolase-like enzyme 1.
  • Nephroblastoma is the commonest paediatric renal malignancy and has a good prognosis except for those with anaplasia.
  • To the best of the authors' knowledge, the expression of TKTL1 in nephroblastomas has not been studied before and the aim of this study was to compare the immunoexpression of TKTL1 in anaplastic and non-anaplastic nephroblastomas.
  • RESULTS: Six of the 15 anaplastic nephroblastomas showed staining in 80-100% of the tumour (p = 0.36).
  • None of the 13 non-anaplastic nephroblastomas showed TKTL1 staining in >80% of the tumour.
  • CONCLUSION: TKTL1 expression is associated with the presence of anaplasia and may be a mechanism via which anaplastic tumour cells thrive under different conditions.
  • Glycolytic inhibitors may play a role in anaplastic nephroblastomas.

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  • (PMID = 19139037.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; EC 2.2.1.1 / TKTL1 protein, human; EC 2.2.1.1 / Transketolase
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30. Wack AN, Miller CL, Wood CE, Garner MM, Haefele HJ: Melanocytic neoplasms in a black rhinoceros (Diceros bicornis) and an Indian rhinoceros (Rhinoceros unicornis). J Zoo Wildl Med; 2010 Mar;41(1):95-103
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  • Aspirate cytology results were suggestive of a melanocytic neoplasm, and histologic examination of the excised mass confirmed a well-differentiated neoplasm with much pigment production, minimal anaplasia, and no mitotic figures.
  • Histologic examination of a biopsy from this lesion revealed a melanocytic neoplasm with moderate cellular anaplasia, frequent mitoses, and scant pigment production.

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  • (PMID = 20722260.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Tantbirojn P, Sanpavat A, Bunyaratavej K, Desudchit T, Shuangshoti S: Desmoplastic infantile ganglioglioma with high proliferation index: report of a case. J Med Assoc Thai; 2005 Dec;88(12):1962-5
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  • However a few examples of DIG with histologic anaplasia have recently been reported, and one demonstrated an unusual aggressive behavior.

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  • (PMID = 16519002.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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32. Khoury JD: Nephroblastic neoplasms. Clin Lab Med; 2005 Jun;25(2):341-61, vi-vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Generally, nephroblastoma is composed of variable proportions of blastema, epithelium, and stroma, each of which may exhibit a wide spectrum of morphologic variations.
  • Distinguishing nephroblastoma with favorable histology from tumors that exhibit anaplasia is an integral component of histologic assessment because of its prognostic and therapeutic implications.
  • Nephrogenic rests and a special variant of nephroblastoma, cystic partially differentiated nephroblastoma, also are discussed.
  • [MeSH-minor] Genes, Wilms Tumor. Genetic Predisposition to Disease. Humans. Neoplasm Staging. Prognosis

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  • (PMID = 15848740.001).
  • [ISSN] 0272-2712
  • [Journal-full-title] Clinics in laboratory medicine
  • [ISO-abbreviation] Clin. Lab. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-023099
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Number-of-references] 129
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33. Kim JH, Cho BK, Kim IO, Park SH: Clear-cell ependymoma of the cerebellum: a case report. Ultrastruct Pathol; 2007 May-Jun;31(3):241-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In addition, the histological features of anaplasia, characterized by increased mitosis and focal pseudopalisading necrosis, were also observed.
  • Ultrastructurally, the intermediate junctions and rudimentary cilia confirmed the ependymal differentiation.

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  • (PMID = 17614003.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 9005-79-2 / Glycogen
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34. Gessi M, Marani C, Geddes J, Arcella A, Cenacchi G, Giangaspero F: Ependymoma with neuropil-like islands: a case report with diagnostic and histogenetic implications. Acta Neuropathol; 2005 Feb;109(2):231-4
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  • We describe a case of ependymoma with neuronal differentiation in form of neuropil-like islands.
  • Brain computed tomography showed a large, partially cystic, parieto-occipital lesion.
  • Despite radiotherapy, the tumor recurred, showing frank features of anaplasia, but lacking the neuropil-like islands.
  • The histological features of the tumor are discussed in the light of the concept that neuronal differentiation can occur occasionally in gliomas of different lineage without affecting the expected biological behavior.

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  • (PMID = 15549332.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Glial Fibrillary Acidic Protein; 0 / MAP2 protein, human; 0 / MIB-1 antibody; 0 / Microtubule-Associated Proteins; 0 / Mucin-1; 0 / Neurofilament Proteins; 0 / Synaptophysin
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35. Horn LC, Kowalzik J, Bilek K, Richter CE, Einenkel J: Prognostic value of trophoblastic proliferation in complete hydatidiform moles in predicting persistent disease. Pathol Res Pract; 2006;202(3):151-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic value of trophoblastic proliferation in complete hydatidiform moles in predicting persistent disease.
  • The correlation between trophoblastic proliferation and development of persistent disease was evaluated.
  • The need for chemotherapy and occurrence of metastatic disease was correlated with the histologic grade using a three-level score.
  • Twelve out of 151 cases were re-evaluated as hydropic abortion, partial moles, or were insufficient for morphologic examination, representing a diagnostic agreement of 92%.
  • A total of 63.4% of the CHM presented with low trophoblastic proliferation with focal areas of slight hyperplasia (grade 1), and 23.7% with moderate proliferation with slight anaplasia and medium-sized sheets of free trophoblast in between the villies (grade 2).
  • In all, 12.9% of the cases showed marked hyperplasia with marked anaplasia and involvement of nearly all villies, as well as a large amount of intervillous trophoblastic sheets (grade 3).
  • Grade 3, on histology, showed a positive correlation with the necessity of chemotherapy (p=0.04), but not with the occurrence of metastatic disease.
  • Histomorphology might predict the risk of persistent disease, indicating the necessity for closer a follow-up, but further studies are required.
  • [MeSH-minor] Adolescent. Adult. Cell Proliferation. Chorionic Gonadotropin / metabolism. Diagnosis, Differential. Disease Progression. Female. Humans. Middle Aged. Neoplasm Metastasis / pathology. Pregnancy. Prognosis

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  • (PMID = 16436315.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin
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36. Wang P, Liu LM, Meng ZQ, Chen Z, Lin JH, Zhou ZH, Chen H, Wang K, Ping B, Wang LF, Wang BH, Huang YF: [Evaluation of the results of fine-needle aspiration liver biopsies and the complications in 2528 cases]. Zhonghua Gan Zang Bing Za Zhi; 2007 Oct;15(10):758-62
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  • In 36 cases (1.42%), suspicious malignancy or anaplasia was suggested.
  • 163 of the 431 negative cases were verified to be malignant in the follow-ups, of which 136 cases were PLC; 28 of the 36 suspicious malignancy or anaplasia were proven to be malignant (all were PLC).

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  • (PMID = 17963603.001).
  • [ISSN] 1007-3418
  • [Journal-full-title] Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
  • [ISO-abbreviation] Zhonghua Gan Zang Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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37. Moradi A, Semnani V, Djam H, Tajodini A, Zali AR, Ghaemi K, Nikzad N, Madani-Civi M: Pathodiagnostic parameters for meningioma grading. J Clin Neurosci; 2008 Dec;15(12):1370-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All slides stained with hematoxylin and eosin were reviewed by two independent pathologists and all the diagnoses reconfirmed; histological anaplasia was classified according to the grading of the WHO Working Group 2000 as benign (Grade I), atypical with incipient signs of anaplasia (Grade II), or overtly anaplastic (Grade III).

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  • (PMID = 18819804.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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38. Kriuchkov AN: [Extent of destructive changes in tumor parenchyma of breast cancer patients of various age]. Vopr Onkol; 2007;53(5):531-4
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  • There was a significant relationship between extent of destructive changes and malignant anaplasia.

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  • (PMID = 18154115.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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39. Park EK, Lee YH, Kim DS, Choi JU, Kim TS, Shim KW: 17-year-old girl with headache and complex partial seizure. Brain Pathol; 2010 Nov;20(6):1111-4
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  • There have been 14 such cases reported in the literature.We report the first case of a supratentorial extraaxial cortical anaplastic ependymoma with minimal cortical attachment in a 17-years-old girl, presented with headache and complex partial seizure.
  • Histological features of anaplasia including numerous mitoses, necrosis and high Ki-67 lead to postoperative adjuvant radiation therapy although gross total resection was achieved.

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  • (PMID = 20925697.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen
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40. O'Neill JP, Power D, Condron C, Bouchier-Hayes D, Walsh M: Anaplastic thyroid cancer, tumorigenesis and therapy. Ir J Med Sci; 2010 Mar;179(1):9-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic thyroid cancer, tumorigenesis and therapy.
  • BACKGROUND: Anaplastic thyroid cancer (ATC) is a fatal endocrine malignancy.
  • Recent insights into thyroid tumorigenesis, post-malignant dedifferentiation and mode of metastatic activity offer new therapeutic strategies.
  • CONCLUSIONS: Significant progress, in the last 5 years, has been made outlining thyroid tumorigenesis and the progression to anaplasia.
  • Continued identification and development of drug therapies is required to counter specific molecular targets responsible for the post-malignant dedifferentiation process and ultimately the fatal neoplastic phenotype.
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Cadherins. Cyclins. Disease Progression. Humans. Radiotherapy. Receptor, Epidermal Growth Factor. Vascular Endothelial Growth Factor A. beta Catenin

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  • (PMID = 19662494.001).
  • [ISSN] 1863-4362
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cadherins; 0 / Cyclins; 0 / Vascular Endothelial Growth Factor A; 0 / beta Catenin; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  • [Number-of-references] 54
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41. Nicol K, Savell V, Moore J, Teot L, Spunt SL, Qualman S, Children's Oncology Group, Soft Tissue Sarcoma Committee: Distinguishing undifferentiated embryonal sarcoma of the liver from biliary tract rhabdomyosarcoma: a Children's Oncology Group study. Pediatr Dev Pathol; 2007 Mar-Apr;10(2):89-97
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  • Histologically, hyaline globules and diffuse anaplasia were consistently present.
  • The cases of RMS had a male:female ratio of 1.8:1 with a median age of 3.4 years and routinely lacked diffuse anaplasia and hyaline globules.
  • [MeSH-minor] Child. Child, Preschool. Diagnosis, Differential. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. MyoD Protein / metabolism. Myogenin / metabolism. Neoplasm Proteins / metabolism. Retrospective Studies. Survival Analysis. Time Factors. Treatment Outcome


42. Watanabe R, Takahashi A, Suzuki M, Toki F, Kanazawa T, Hirato J, Morikawa A, Kuwano H: Adolescent wilms tumor with intraspinal and bone metastases: a case report and the review of literature. J Pediatr Hematol Oncol; 2009 Jan;31(1):45-8
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  • The histology of both tumors was nephroblastoma with no anaplasia and favorable histology, and they were diagnosed as stage IV.
  • The patient has remained in disease-free remission for 45 months after the surgical resection.
  • Intensive multimodality therapy including DD-4A regimen of National Wilms' Tumor Study can result in long-term disease-free remission.

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  • (PMID = 19125087.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Perry A, Miller CR, Gujrati M, Scheithauer BW, Zambrano SC, Jost SC, Raghavan R, Qian J, Cochran EJ, Huse JT, Holland EC, Burger PC, Rosenblum MK: Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. Brain Pathol; 2009 Jan;19(1):81-90
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  • The PNET-like component consisted of sharply demarcated hypercellular nodules with evidence of neuronal differentiation.
  • Anaplasia, as seen in medulloblastomas, was noted in 70%.
  • (iii) often shows histologic anaplasia and N-myc (or c-myc) amplification;.

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  • (PMID = 18452568.001).
  • [ISSN] 1750-3639
  • [Journal-full-title] Brain pathology (Zurich, Switzerland)
  • [ISO-abbreviation] Brain Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0 / Proto-Oncogene Proteins; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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44. O'Neill JP, O'Neill B, Condron C, Walsh M, Bouchier-Hayes D: Anaplastic (undifferentiated) thyroid cancer: improved insight and therapeutic strategy into a highly aggressive disease. J Laryngol Otol; 2005 Aug;119(8):585-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anaplastic (undifferentiated) thyroid cancer: improved insight and therapeutic strategy into a highly aggressive disease.
  • BACKGROUND: This review article discusses the clinical and diagnostic implications of anaplastic thyroid cancer, recognizing the aggressive nature of the disease and extensive disease progression upon diagnosis.
  • We question the pathological evolution of anaplasia as a 'de novo' disease or a post malignant transformation or dedifferentiation and the therapeutic implications of p53 mutation.
  • METHOD: An electronic search on Medline and Pubmed was performed under 'anaplastic thyroid carcinoma', 'anaplastic thyroid carcinogenesis', 'anaplastic thyroid carcinoma treatment reviews'.

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  • (PMID = 16102210.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 85
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45. Nataf F, Tucker ML, Varlet P, Koziak M, Beuvon F, Daumas-Duport C, Roux FX: [Oligodendrogliomas: historical background of classifications]. Neurochirurgie; 2005 Sep;51(3-4 Pt 2):219-27
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  • Then Kernohan introduced, in 1938, the concept of anaplasia.

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  • (PMID = 16292165.001).
  • [ISSN] 0028-3770
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] France
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46. Yaris N, Nas Y, Cobanoglu U, Yavuz MN: Thymic carcinoma in children. Pediatr Blood Cancer; 2006 Aug;47(2):224-7
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  • Carcinomas are malignant tumors of the thymus characterized by obvious cytological anaplasia.
  • However, she died within 15 months due to progressive disease.

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  • (PMID = 16007580.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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47. Teruya-Feldstein J, Gopalan A, Moskowitz CH: CD5 negative, Cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) presenting as ruptured spleen. Appl Immunohistochem Mol Morphol; 2009 May;17(3):255-8
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  • Tumor cells showed marked pleomorphism, anaplasia, and increased mitotic figures with positive Cyclin D1, BCL6, MUM1, P53, and a high MIB1 proliferative fraction.
  • This case raises the differential diagnoses of pleomorphic mantle cell lymphoma and other aggressive lymphomas with pleomorphic, anaplastic, and Reed-Sternberg-like cells.

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  • (PMID = 18838919.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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48. Faussillon M, Murakami I, Bichat M, Telvi L, Jeanpierre C, Nezelof C, Jaubert F, Gogusev J: Molecular cytogenetic anomalies and phenotype alterations in a newly established cell line from Wilms tumor with diffuse anaplasia. Cancer Genet Cytogenet; 2008 Jul;184(1):22-30
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  • [Title] Molecular cytogenetic anomalies and phenotype alterations in a newly established cell line from Wilms tumor with diffuse anaplasia.
  • The novel continuous cell line WT-Pe.1 was established in vitro from Wilms tumor with histological features of diffuse anaplasia.
  • The cultures grew as poorly differentiated epithelial-like cells with pleomorphic polygonal shapes and formation of typical monolayers.

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  • Cellosaurus - a cell line knowledge resource. culture/stock collections - WT-Pe.1 (CVCL_M844) .
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  • (PMID = 18558285.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Duggal N, Taylor R, Zou GY, Hammond RR: Dysembryoplastic neuroepithelial tumours: clinical, proliferative and apoptotic features. J Clin Pathol; 2008 Jan;61(1):127-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Fourteen consecutive surgical specimens meeting the histological criteria for DNT were retrospectively reviewed for evidence of aggressive histological features, including anaplasia, mitotic activity, and Ki67 labelling.

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  • (PMID = 17513508.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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50. Seethala RR, Barnes EL, Hunt JL: Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol; 2007 Jan;31(1):44-57
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, new morphologies in EMCa such as ancient change (8.2%), "Verocay"-like change (3.3%), and sebaceous differentiation (13.1%) were noted.
  • Specific histologic variants were dedifferentiated EMCa (3.3%), oncocytic EMCa (8.2%), EMCa ex pleomorphic adenoma (1.6%), double-clear EMCa (3.3%), and EMCa with myoepithelial anaplasia (3.3%).
  • p53 was highly expressed only in 1 dedifferentiated EMCa.
  • The recurrence rate was 36.3% (median disease-free survival 11.34 y), but death was rare with 5-year and 10-year disease-specific survivals of 93.5% and 81.8%, respectively.
  • The most important univariate predictors of recurrence were margin status (log rank P=0.006), angiolymphatic invasion (P=0.002), tumor necrosis (P=0.004), and myoepithelial anaplasia (P=0.038).
  • Thus, EMCa is generally a low-grade tumor with a broader morphologic spectrum than previously thought, with several key features predictive of recurrence.


51. Margareto J, Leis O, Larrarte E, Idoate MA, Carrasco A, Lafuente JV: Gene expression profiling of human gliomas reveals differences between GBM and LGA related to energy metabolism and notch signaling pathways. J Mol Neurosci; 2007;32(1):53-63
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  • Human gliomas are classified according to the extent of anaplasia or 'de-differentiation' appearance.
  • Present work reports interesting results that might be useful to differentiate between tumor grades.

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  • (PMID = 17873288.001).
  • [ISSN] 0895-8696
  • [Journal-full-title] Journal of molecular neuroscience : MN
  • [ISO-abbreviation] J. Mol. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Notch
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52. Bignold LP: Variation, "evolution", immortality and genetic instabilities in tumour cells. Cancer Lett; 2007 Aug 18;253(2):155-69

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • "degrees of de-differentiation") between cases of the same tumour type and between different foci within individual tumours.
  • Nevertheless, apart from Hansemann's ideas of "anaplasia" and "de-differentiation" (proposed in the 1890s), and supposed "evolutionary themes" in cancer cell biology, little has been published concerning how histopathologic variation and immortality in tumour cells might arise.

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  • (PMID = 17250959.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 117
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53. Aloudah NM, Raddaoui E, Aldhahri S, Al-Abbadi MA: Low-grade papillary cystadenocarcinoma of the parotid gland: presentation of a case with cytological, histopathological, and immunohistochemical features and pertinent literature review. Diagn Cytopathol; 2009 Feb;37(2):128-31
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  • The nuclei are eccentric, bland appearing, round, and at the most part uniform in size without anaplasia or mitotic activity.

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  • (PMID = 19021236.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-7
  • [Number-of-references] 20
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54. Shen CS, Tsuda T, Fushiki S, Mizutani H, Yamanishi K: The expression of p63 during epidermal remodeling in psoriasis. J Dermatol; 2005 Apr;32(4):236-42
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  • The p63 transcription factor, a homologue of the p53 tumor suppressor, has been implicated in the maintenance of epidermal stem cells and the stratification of the epidermis. p63 is up-regulated in squamous cell carcinomas with anaplasia, suggesting that it is also associated with epidermal hyperplasia.

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  • (PMID = 15863843.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins
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55. Kido M, Ueno M, Onodera M, Matsumoto K, Imai T, Haba R, Tamiya T, Huang CL, Sakamoto H: Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin. Pathol Int; 2009 Apr;59(4):255-60
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  • [Title] Medulloblastoma with myogenic differentiation showing double immunopositivity for synaptophysin and myoglobin.
  • Reported herein is a case of medulloblastoma with myogenic differentiation in a 3-year-old girl who died 1 year after appearance of clinical signs.
  • Magnetic resonance imaging indicated a mass lesion in the cerebellar vermis.
  • The diagnosis was medulloblastoma with myogenic differentiation, also known as medullomyoblastoma.
  • The tumor cells had large nuclei, frequent mitoses, apoptoses, nuclear molding, and cell wrapping, indicating moderate anaplasia.
  • In addition, some tumor cells had double immunopositivity for synaptophysin or neurofilament and myoglobin, suggesting that the neuroectodermal cells may undergo differentiation into rhabdomyoblasts.
  • [MeSH-minor] Cell Differentiation. Child, Preschool. Combined Modality Therapy. Fatal Outcome. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Muscle Cells / pathology

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  • [ErratumIn] Pathol Int. 2010 Jul;60(7):542
  • (PMID = 19351370.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Myoglobin; 0 / Synaptophysin
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56. Zheng JM, Tao X, Xu AM, Chen XF, Wu MC, Zhang SH: Primary and recurrent embryonal sarcoma of the liver: clinicopathological and immunohistochemical analysis. Histopathology; 2007 Aug;51(2):195-203
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  • Recurrent tumours showed greater cellularity, anaplasia and pluripotential differentiation compared with the primary tumour.
  • Immunohistochemistry showed evidence of widely divergent differentiation into mesenchymal and epithelial phenotypes.
  • CONCLUSIONS: Embryonal sarcoma of the liver may undergo pluripotential differentiation and diagnosis should be based mainly on morphological features.
  • [MeSH-minor] Actins / metabolism. Adolescent. Adult. Biomarkers, Tumor / metabolism. Cell Differentiation. Child. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Proteins / metabolism. alpha 1-Antitrypsin / metabolism. alpha-Fetoproteins

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  • (PMID = 17573940.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / Actins; 0 / Biomarkers, Tumor; 0 / Proteins; 0 / alpha 1-Antitrypsin; 0 / alpha-Fetoproteins
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57. Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanabe T, Saito N, Tsuzuki K, Okado H, Miwa A, Nakazato Y, Ozawa S: Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. J Neurosci; 2007 Jul 25;27(30):7987-8001
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  • The activation of the glutamate-AMPA receptor-Akt pathway may contribute to the high degree of anaplasia and invasive growth of human glioblastoma.

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  • (PMID = 17652589.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, AMPA; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; SY7Q814VUP / Calcium
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58. Fan GG, Deng QL, Wu ZH, Guo QY: Usefulness of diffusion/perfusion-weighted MRI in patients with non-enhancing supratentorial brain gliomas: a valuable tool to predict tumour grading? Br J Radiol; 2006 Aug;79(944):652-8

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  • 14 low-grade gliomas (WHO Grade I and II) and 8 anaplastic gliomas were verified histologically.
  • The results showed that lower ADC values were present in the solid portions of anaplastic gliomas, but not in low grade (p < 0.01).
  • However, there was no significant difference between anaplastic gliomas and low-grade gliomas.
  • Meanwhile, higher rCBV ratios were present in both solid portions and peritumoural regions of anaplastic gliomas, but not in low grade gliomas (p < 0.01).
  • In conclusion, non-enhancing brain gliomas with lower ADC values in the solid portions and higher rCBV ratios in both solid portions and peritumoural regions of tumours are significantly correlated with anaplasia.

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  • (PMID = 16641420.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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59. Mineo JF, Bordron A, Quintin-Roué I, Maurage CA, Buhé V, Loisel S, Dubois F, Blond S, Berthou C: Increasing of HER2 membranar density in human glioblastoma U251MG cell line established in a new nude mice model. J Neurooncol; 2006 Feb;76(3):249-55
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  • HER2 is not expressed in adult glial cells, but its expression increases with the degree of astrocytomas anaplasia.
  • [MeSH-major] Brain Neoplasms / metabolism. Disease Models, Animal. Glioblastoma / metabolism. Receptor, ErbB-3 / metabolism

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  • [ErratumIn] J Neurooncol. 2007 Sep;84(3):331. Isabelle, Quintin-Roué [corrected to Quintin-Roué, Isabelle]; Virginie, Buhé [corrected to Buhé, Virginie]; Séverine, Loisel [corrected to Loisel, Séverine]
  • (PMID = 16200345.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, ErbB-3
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60. Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massagué J: Tumor self-seeding by circulating cancer cells. Cell; 2009 Dec 24;139(7):1315-26
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  • Tumor self-seeding could explain the relationships between anaplasia, tumor size, vascularity and prognosis, and local recurrence seeded by disseminated cells following ostensibly complete tumor excision.

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
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  • (PMID = 20064377.001).
  • [ISSN] 1097-4172
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] ENG
  • [Databank-accession-numbers] GEO/ GSE18833
  • [Grant] United States / NCI NIH HHS / CA / P30 CA008748; United States / NCI NIH HHS / CA / CA94060; United States / Howard Hughes Medical Institute / / ; United States / NCI NIH HHS / CA / P01 CA094060; United States / NCI NIH HHS / CA / CA094060-06A10002; United States / NCI NIH HHS / CA / P01 CA094060-06A10002
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ NIHMS160208; NLM/ PMC2810531
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61. Wang Y, Xiong J, Chu SG, Liu Y, Cheng HX, Wang YF, Zhao Y, Mao Y: Rosette-forming glioneuronal tumor: report of an unusual case with intraventricular dissemination. Acta Neuropathol; 2009 Dec;118(6):813-9

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  • No histological anaplasia was present.

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  • (PMID = 19585134.001).
  • [ISSN] 1432-0533
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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62. Guo SP, Zhang F, Li QL, Li Q, Wang WL, Li FF: Papillary glioneuronal tumor--contribution to a new tumor entity and literature review. Clin Neuropathol; 2008 Mar-Apr;27(2):72-7
MedlinePlus Health Information. consumer health - Brain Tumors.

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  • We present a new case of this rare entity, representing the 3rd case of this lesion in Chinese patients and review the findings in 34 patients from different case reports found in the international literature.
  • This report describes a histologically similar-appearing lesion arising in the left frontoparietal lobe of a 23-year-old man.
  • Signs of anaplasia, in particular mitotic figures, endothelial proliferation or necrosis were consistently lacking.

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  • (PMID = 18402385.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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63. Ota S, Ushijima K, Nishio S, Fujiyoshi N, Takemoto S, Terada A, Kamura T: Polypoid endocervical adenomyoma: a case report with clinicopathologic analyses. J Obstet Gynaecol Res; 2007 Jun;33(3):363-7
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  • No distinct nuclear anaplasia, architectural abnormality or any evidence of destructive stromal invasion was observed.
  • In the present case, the tumor was a well-circumscribed polypoid lesion, with no cytologic or architectural abnormality; however, focal immunoreactivity was shown for HIK-1083, which thus suggested it to be PEA.

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  • (PMID = 17578368.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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64. Caracciolo V, D'Agostino L, Dráberová E, Sládková V, Crozier-Fitzgerald C, Agamanolis DP, de Chadarévian JP, Legido A, Giordano A, Dráber P, Katsetos CD: Differential expression and cellular distribution of gamma-tubulin and betaIII-tubulin in medulloblastomas and human medulloblastoma cell lines. J Cell Physiol; 2010 May;223(2):519-29
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  • Overexpression of gamma-tubulin was widespread in poorly differentiated, proliferating tumor cells but was significantly diminished in quiescent differentiating tumor cells undergoing neuritogenesis, highlighted by betaIII-tubulin immunolabeling.
  • Our data indicate that overexpression of gamma-tubulin may be linked to phenotypic dedifferentiation (anaplasia) and tumor progression in medulloblastomas and may potentially serve as a promising tumor marker.
  • [MeSH-minor] Cell Cycle / physiology. Cell Dedifferentiation / physiology. Cell Line, Tumor. Centrosome / metabolism. Child. Child, Preschool. Cytoplasm / metabolism. Disease Progression. Female. Gene Expression Regulation, Neoplastic / physiology. Humans. Immunohistochemistry. Infant. Male. Protein Isoforms / genetics. Protein Isoforms / metabolism. Retrospective Studies. Spindle Apparatus / metabolism

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  • (PMID = 20162618.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protein Isoforms; 0 / TUBB3 protein, human; 0 / Tubulin
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65. Arab MR, Salari S, Karimi M, Mofidpour H: Lectin histochemical study of cell surface glycoconjugate in gastric carcinoma using helix pomatia agglutinin. Acta Med Iran; 2010 Jul-Aug;48(4):209-13
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  • Altered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells.
  • [MeSH-minor] Cell Differentiation. Cell Membrane / metabolism. Humans. Paraffin Embedding

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  • (PMID = 21279930.001).
  • [ISSN] 1735-9694
  • [Journal-full-title] Acta medica Iranica
  • [ISO-abbreviation] Acta Med Iran
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Iran
  • [Chemical-registry-number] 0 / Glycoconjugates; 0 / Helix lectin; 0 / Lectins
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66. Sarin H, Manucha V, Verma K: Extramedullary plasmacytoma, a report of five cases diagnosed by FNAC. Cytopathology; 2009 Oct;20(5):328-31

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  • Presence of anaplasia, increased plasmablasts, numerous naked nuclei and unusual location of the tumour were some of the challenges faced during the cytological evaluation.

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  • (PMID = 19416311.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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67. Parham DM, Qualman SJ, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, Meyer WH, Soft Tissue Sarcoma Committee of the Children's Oncology Group: Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Am J Surg Pathol; 2007 Jun;31(6):895-901
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The possibility of morphologic variation among these molecular subtypes has not been investigated.
  • We evaluated cytohistologic parameters such as microcyst formation, solid foci, differentiation, giant cell formation, anaplasia, nuclear grade, mitosis/karyorrhexis index, rosette formation, geographic necrosis, presence and amount of rhabdomyoblastic differentiation, and the presence of foci resembling embryonal rhabdomyosarcoma.

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  • (PMID = 17527077.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 98543; United States / NCI NIH HHS / CA / CA24507; United States / NCI NIH HHS / CA / CA72989; United States / NCI NIH HHS / CA / CA81659; United States / NCI NIH HHS / CA / CA89461; United States / NCI NIH HHS / CA / CA98413; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FOXO1 protein, human; 0 / Forkhead Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / PAX3 protein, human; 0 / PAX7 Transcription Factor; 0 / PAX7 protein, human; 0 / Paired Box Transcription Factors
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68. Morikawa T, Nagata M, Tomita K, Kitamura T, Goto A, Chong JM, Fukayama M: Phyllodes tumor of the prostate with exuberant glandular hyperplasia. Pathol Int; 2006 Mar;56(3):158-61
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  • The following features of the resected tumor were helpful for concluding that these acini were benign: lack of cytological anaplasia in spite of structural atypia, presence of scattered basal cells confirmed by immunohistochemistry (high-molecular-weight cytokeratin), and histological transition from these acini to apparently benign slit-like glands.

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  • (PMID = 16497250.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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69. Preusser M, Wolfsberger S, Czech T, Slavc I, Budka H, Hainfellner JA: Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome. Am J Clin Pathol; 2005 Oct;124(4):543-9
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  • Survivin expression has been described as prognostic factor in various tumor types and has been shown to correlate with cytologic anaplasia in ependymoma.

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  • (PMID = 16146813.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Cysteine Proteinase Inhibitors; 0 / DNA-Binding Proteins; 0 / Inhibitor of Apoptosis Proteins; 0 / Ki-67 Antigen; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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70. Parsa CF, Givrad S: Juvenile pilocytic astrocytomas do not undergo spontaneous malignant transformation: grounds for designation as hamartomas. Br J Ophthalmol; 2008 Jan;92(1):40-6
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  • METHODS: A literature search was performed, cross-referencing juvenile pilocytic astrocytoma, pilocytic astrocytoma, astrocytoma grade I, optic glioma, glioma, low-grade gliomas, polar spongioblastoma, gliocytoma embryonale, and malignant transformation, anaplasia or anaplastic change.
  • Six other cases were located within the irradiated field but represented anaplasias developing independently of the primary tumour.
  • CONCLUSION: Juvenile pilocytic astrocytomas WHO grade I do not undergo spontaneous anaplastic transformation.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Disease Progression. Humans. Middle Aged. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 17962395.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 90
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71. V'lckova-Laskoska MT, Laskoski DS: Keratoacanthoma centrifugum marginatum: a rare atypical variant of keratoacanthoma. Clin Exp Dermatol; 2008 May;33(3):259-61
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  • Clinically, KA is an exoendophytic lesion of 10-25 mm with a horn-filled crater that resolves spontaneously within 6 months.
  • Histologically, KCM is similar to KA, with a central keratin-filled crater, overhanging lips of epithelium, a sharp outline between the tumour nests and stroma, and lack of anaplasia and stroma desmoplasia.

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  • (PMID = 18076683.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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72. Jayawardena S, Sooriabalan D, Indulkar S, Kim HH, Matin A, Maini A: Regression of grade III astrocytoma during the treatment of CML with imatinib mesylate. Am J Ther; 2006 Sep-Oct;13(5):458-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The cells that demonstrate the greatest degree of anaplasia are used to determine the histologic grade of the tumor.
  • The mean age of survival are approximately 10 years from the time of diagnosis for pilocystic astrocytomas (World Health Organization grade I), more than 5 years for patients with low-grade diffuse astrocytomas (WHO grade II), 2 to 5 years for those with anaplastic astrocytomas (WHO grade III), and less than 1 year for patients with glioblastoma (WHO grade IV).

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  • (PMID = 16988542.001).
  • [ISSN] 1075-2765
  • [Journal-full-title] American journal of therapeutics
  • [ISO-abbreviation] Am J Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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73. Matsuzaki K, Uno M, Kageji T, Hirose T, Nagahiro S: Anaplastic ganglioglioma of the cerebellopontine angle. Case report. Neurol Med Chir (Tokyo); 2005 Nov;45(11):591-5
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  • [Title] Anaplastic ganglioglioma of the cerebellopontine angle. Case report.
  • A 64-year-old woman presented with a rare anaplastic ganglioglioma in the right cerebellopontine angle manifesting as dizziness persisting for 2 weeks.
  • Preoperative magnetic resonance (MR) imaging revealed a partially enhanced cystic lesion of the right cerebellopontine angle.
  • Histological examination showed neoplastic ganglional and glial cells with anaplastic features such as mitosis, pleomorphism, and endothelial proliferation.
  • The diagnosis was anaplastic ganglioglioma (World Health Organization grade IV).
  • Histological features of anaplasia and a high MIB-1 labeling index may be predictive of a poor clinical outcome.

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  • (PMID = 16308520.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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74. Robles SG, Gatignol P, Lehéricy S, Duffau H: Long-term brain plasticity allowing a multistage surgical approach to World Health Organization Grade II gliomas in eloquent areas. J Neurosurg; 2008 Oct;109(4):615-24
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  • Based on their experience with these cases, the authors suggest that in cases of incomplete glioma removal, a second operation before anaplasia should be considered, made possible by brain reorganization after the first operation.

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  • (PMID = 18826347.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Zhu XG, Zhao L, Willingham MC, Cheng SY: Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinoma. Oncogene; 2010 Apr 1;29(13):1909-19
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  • As these mice aged, they spontaneously developed follicular thyroid carcinoma with pathological progression from hyperplasia to capsular invasion, vascular invasion, anaplasia and metastasis to the lung, similar to human thyroid cancer.
  • [MeSH-minor] Animals. Cell Proliferation / drug effects. Disease Models, Animal. Humans. Mice. Mutation. Signal Transduction / genetics


76. Dadras SS, Skrzypek A, Nguyen L, Shin JW, Schulz MM, Arbiser J, Mihm MC, Detmar M: Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J Invest Dermatol; 2008 Dec;128(12):2798-806
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  • Surprisingly, we found that expression of Prox1 was sufficient to induce a more aggressive behavior of tumors growing in syngenic mice, leading to enhanced local invasion into the muscular layer and to cellular anaplasia in vivo, and increased migration rate in vitro.
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Movement. Disease Models, Animal. Humans. Membrane Glycoproteins / metabolism. Mice. Neoplasm Invasiveness. Oligonucleotide Array Sequence Analysis. Vascular Endothelial Growth Factor Receptor-3 / metabolism

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  • (PMID = 18580962.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA69184; United States / NCI NIH HHS / CA / CA86410; United States / NCI NIH HHS / CA / CA92644
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gp38 protein, mouse; 0 / Homeodomain Proteins; 0 / Membrane Glycoproteins; 0 / Tumor Suppressor Proteins; 0 / prospero-related homeobox 1 protein; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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77. Tirabosco R, De Maglio G, Skrap M, Falconieri G, Pizzolitto S: Expression of the Polycomb-Group protein BMI1 and correlation with p16 in astrocytomas an immunohistochemical study on 80 cases. Pathol Res Pract; 2008;204(9):625-31
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  • BMI1, the prototype PcG gene, is critically involved in cell cycle control and differentiation, and despite the regulatory role demonstrated in central nervous system (CNS) development, its implication in brain tumorigenesis is scarcely known.
  • However, when the 22 BMI1 + /p16+ tumors were examined cytologically, a substantial proportion contained a significant gemistocytic component, which is thought to be an adverse prognostic factor or to display a high degree of anaplasia, suggesting a common molecular mechanism of BMI1/p16 pathway disruption, which may have prognostic implications.

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  • (PMID = 18450386.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / BMI1 protein, human; 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
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78. Eberhart CG, Chaudhry A, Daniel RW, Khaki L, Shah KV, Gravitt PE: Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus. BMC Cancer; 2005 Feb 17;5:19
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  • [Title] Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus.
  • BACKGROUND: p53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes.
  • RESULTS: p53 expression was detected in 18% of non-anaplastic medulloblastomas, 45% of anaplastic medulloblastomas, 67% of ATRT, and 88% of sPNET.
  • The increased p53 immunoreactivity in anaplastic medulloblastoma, ATRT, and sPNET was statistically significant.
  • CONCLUSION: Immunoreactivity for p53 protein is more common in anaplastic medulloblastomas, ATRT and sPNET than in non-anaplastic tumors, and is associated with worse clinical outcomes.

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  • (PMID = 15717928.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS043279; United States / NINDS NIH HHS / NS / K08NS43279
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
  • [Other-IDs] NLM/ PMC554768
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79. Srikantha U, Balasubramaniam A, Santosh V, Somanna S, Bhagavatula ID, Ashwathnarayana CB: Recurrence in medulloblastoma - influence of clinical, histological and immunohistochemical factors. Br J Neurosurg; 2010 Jun;24(3):280-8
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  • CONCLUSION: We propose a clinical-histological-immunohistochemical' model for medulloblastoma where extent of resection, administration of chemotherapy, presence of gross anaplasia and c-erb B2 overexpression status are the most important predictors of recurrence rates.

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  • (PMID = 20465457.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, ErbB-2
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80. Ramdial PK, Hadley GP, Sing Y: Spinal cord compression in children with Wilms' tumour. Pediatr Surg Int; 2010 Apr;26(4):349-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Imaging showed epidural masses with paraspinal disease, cord displacement and compression.
  • Histology revealed triphasic WT with one case showing anaplasia.
  • CONCLUSION: Although rare, WT-associated spinal disease may cause permanent neurological deficit, adding considerably to the burden of disease.

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  • (PMID = 20148252.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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81. Basta-Jovanovic G, Gvozdenovic E, Dimitrijevic I, Brasanac D, Jovanovic M, Kalezic N, Baralic I, Radojevic-Skodric S, Arsic D: Immunohistochemical analysis of gamma catenin in Wilms' tumors. Fetal Pediatr Pathol; 2008;27(2):63-70
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  • Expression of gamma-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative.

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  • (PMID = 18568994.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Desmoplakins; 0 / JUP protein, human
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82. Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C, Reinheckel T: Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene; 2008 Jul 10;27(30):4191-9
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  • Using Ctsb-deficient mice we investigated tumour cell differentiation, proliferation and apoptosis in the Tg(MMTV-PyMT) mouse mammary cancer model.
  • Thus, our results indicate an in vivo role for Ctsb in promoting cellular anaplasia in mammary cancers and proliferation in lung metastases.
  • [MeSH-minor] Animals. Cell Death / genetics. Disease Progression. Female. Lung Neoplasms / genetics. Lung Neoplasms / secondary. Mice. Mice, Knockout. Neoplasm Transplantation. Time Factors. Tumor Cells, Cultured

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  • (PMID = 18345026.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.4.22.1 / Cathepsin B
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83. Siddiqui MT, Mahon BM, Cochran E, Gattuso P: Cytologic features of meningiomas on crush preparations: a review. Diagn Cytopathol; 2008 Apr;36(4):202-6

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  • The presence of nuclear anaplasia, macronucleoli, mitotic activity, and sheet-like growth may suggest an atypical meningioma.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18335550.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Moricz Ad, Melo M, Castro AM, Campos T, Silva RA, Pacheco AM Jr: Prevalence of Helicobacter spp in chronic cholecystitis and correlation with changes on the histological pattern of the gallbladder. Acta Cir Bras; 2010 Jun;25(3):218-24
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  • In pathological examination of the gallbladder, were evaluated the presence of metaplasia, dysplasia, lymphoid follicles, anaplasia and tumors that might be related to the presence of Helicobacter plus the presence of the bacilli Giemsa(+) by optical microscopy.

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  • (PMID = 20498933.001).
  • [ISSN] 1678-2674
  • [Journal-full-title] Acta cirurgica brasileira
  • [ISO-abbreviation] Acta Cir Bras
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / DNA, Bacterial
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85. Taguchi S, Shono T, Mori D, Horie H: Extrarenal Wilms tumor in children with unfavorable histology: a case report. J Pediatr Surg; 2010 Sep;45(9):e19-22
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  • Pathologic diagnosis of the tumor was extrarenal Wilms tumor with diffuse anaplasia.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20850611.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Ko EY, Ritchey ML: Current management of Wilms' tumor in children. J Pediatr Urol; 2009 Feb;5(1):56-65
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  • However, outcomes for patients with rhabdoid tumors and diffuse anaplasia remain poor.


87. Djuricić S, Djokić D, Vujić D, Basta-Jovanović G, Todorović V, Radojević-Skodrić S, Zdravković S, Vujanić GM: [Immunohistochemical expression of p53 oncoprotein in Wilms tumour in relation to histological components, histological types and preoperative chemotherapy]. Srp Arh Celok Lek; 2008 Dec;136 Suppl 4:298-306
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  • It was significantly correlated to WT histological prognostic types (p = 0.039).The exensivity of p53 immunoexpression was higher in anaplastic components but a difference between WT type of diffuse anaplasia and all other types was nonsignificant (p = 0.10).
  • The anaplastic component had noticeable but statistically not significantly higher p53 immunoexpression than non-anaplastic.

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  • (PMID = 20804099.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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88. Melnick M, Mocarski ES, Abichaker G, Huang J, Jaskoll T: Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. BMC Dev Biol; 2006 Sep 07;6:42
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  • CONCLUSION: mCMV infection of embryonic mouse explants results in dysplasia, metaplasia, and, possibly, anaplasia.

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  • (PMID = 16959038.001).
  • [ISSN] 1471-213X
  • [Journal-full-title] BMC developmental biology
  • [ISO-abbreviation] BMC Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / DE014535-04; United States / PHS HHS / / R01 A130363; United States / NIDCR NIH HHS / DE / R01 DE014535-04; United States / NEI NIH HHS / EY / P30 EY003040; United States / NEI NIH HHS / EY / EY03040; United States / NIDCR NIH HHS / DE / R01 DE014535
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1601957
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89. Park S, Suh YL, Nam DH, Kim ST: Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types. Clin Neuropathol; 2009 Mar-Apr;28(2):73-82
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  • Pathologic features included the amount of rod cells and cytologic anaplasia such as multinucleated tumor giant cells, endothelial cell proliferation, or mitosis.
  • Histologically, 33 cases of GC were classified into two histologic grades (low and high grade) by cytologic anaplasia.
  • Immunohistochemical results demonstrated that the infiltrating tumor cells were undifferentiated cells with astrocytic or oligodendroglial differentiation.
  • [MeSH-minor] Adult. Anaplasia. Astrocytes / pathology. Astrocytes / physiology. Cell Proliferation. Endothelial Cells / pathology. Female. Giant Cells / pathology. Glial Fibrillary Acidic Protein / metabolism. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging. Male. Middle Aged. Oligodendroglia / pathology. Oligodendroglia / physiology. Survival Analysis. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19353837.001).
  • [ISSN] 0722-5091
  • [Journal-full-title] Clinical neuropathology
  • [ISO-abbreviation] Clin. Neuropathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
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90. Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S: A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid; 2009 Oct;19(10):1077-84
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  • [Title] A novel orthotopic mouse model of human anaplastic thyroid carcinoma.
  • METHODS: We used the cell line 8505c, originated from a thyroid tumor histologically characterized by anaplastic carcinoma cell features.
  • RESULTS: Orthotopic implantation with the 8505c cells produced thyroid tumors after 5 weeks, showing large neck masses, with histopathologic features of a high-grade neoplasm (anaplasia, necrosis, high mitotic and proliferative indexes, p53 positivity, extrathyroidal invasion, lymph node and distant metastases) and immunoprofile of follicular thyroid cell origin with positivity for thyroid transcription factor-1 and PAX8, and for cytokeratins.
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Proliferation. Disease Models, Animal. Genes, p53 / genetics. Humans. Immunohistochemistry. Mice. Neoplasm Transplantation. Proto-Oncogene Proteins B-raf / genetics. Thyroid Gland / cytology. Thyroid Gland / pathology. Transfection

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  • (PMID = 19772429.001).
  • [ISSN] 1557-9077
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA149738
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Other-IDs] NLM/ PMC2833178
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91. Stockhammer F, Plotkin M, Amthauer H, van Landeghem FK, Woiciechowsky C: Correlation of F-18-fluoro-ethyl-tyrosin uptake with vascular and cell density in non-contrast-enhancing gliomas. J Neurooncol; 2008 Jun;88(2):205-10
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  • OBJECTIVE: Even without contrast enhancement on MRI scans gliomas can show histological features of anaplasia.
  • These tumors are heterogeneous regarding anaplastic and non-anaplastic areas.
  • RESULTS: 12 of the 22 non-contrast enhancing gliomas corresponded to anaplastic astrocytomas WHO grade III.

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  • (PMID = 18317691.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 42HK56048U / Tyrosine
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92. Fathi AR, Novoa E, El-Koussy M, Kappeler A, Mariani L, Vajtai I: Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up. Pathol Res Pract; 2008;204(5):345-51
Hazardous Substances Data Bank. DACARBAZINE .

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  • Twelve years into clinical history, the patient has stable minimal residual disease at the age of 65.
  • A review of pathology samples from both surgeries showed well-differentiated astroblastoma according to current standards, with an MIB-1 labeling index of 1% and 4%, respectively.
  • Neither of the specimens involved cellular anaplasia, overt mitotic activity, microvascular proliferation, or palisading necrosis.
  • Involving a low-grade parent neoplasm, it also further substantiates the incipient perception that the rhabdoid phenotype neither is a peculiar but nonspecific convergence point of anaplastic evolution, nor are such lesions indiscriminately bound for a relentless course.
  • [MeSH-minor] Antibodies, Antinuclear. Antibodies, Monoclonal. Antineoplastic Agents, Alkylating / therapeutic use. Cell Differentiation. Cerebral Angiography. Chemotherapy, Adjuvant. Craniotomy. Dacarbazine / analogs & derivatives. Dacarbazine / therapeutic use. Glial Fibrillary Acidic Protein / analysis. Humans. Ki-67 Antigen / analysis. Magnetic Resonance Imaging. Male. Middle Aged. Radiotherapy, Adjuvant. Reoperation. Time Factors. Treatment Outcome. Vimentin / analysis

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  • (PMID = 18280055.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents, Alkylating; 0 / Glial Fibrillary Acidic Protein; 0 / Ki-67 Antigen; 0 / MIB-1 antibody; 0 / Vimentin; 7GR28W0FJI / Dacarbazine; 85622-93-1 / temozolomide
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93. Kim YJ, Ketter R, Henn W, Zang KD, Steudel WI, Feiden W: Histopathologic indicators of recurrence in meningiomas: correlation with clinical and genetic parameters. Virchows Arch; 2006 Nov;449(5):529-38

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  • Independent predictors of recurrence included (1) anaplasia;.

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  • (PMID = 17016718.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
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94. Vajtai I, Kappeler A, Lukes A, Arnold M, Lüthy AR, Leibundgut K: Papillary glioneuronal tumor. Pathol Res Pract; 2006;202(2):107-12
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  • The descriptive term papillary glioneuronal tumor (PGNT) has been repeatedly applied to a morphologic subset of low-grade mixed glial-neuronal neoplasia of juvenile and young adult patients.
  • Focally, the latter imprinted a pseudopapillary aspect on this otherwise solid lesion.
  • Signs of anaplasia, in particular mitotic figures, endothelial proliferation, or necrosis were consistently lacking.

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  • (PMID = 16413693.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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95. Li W, Kessler P, Yeger H, Alami J, Reeve AE, Heathcott R, Skeen J, Williams BR: A gene expression signature for relapse of primary wilms tumors. Cancer Res; 2005 Apr 1;65(7):2592-601
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  • Anaplastic histology and metastasis are each associated with higher relapse and mortality rates in Wilms tumor patients.
  • However, not all anaplastic tumors relapse and some nonanaplastic tumors relapse unexpectedly.
  • This analysis revealed that expression of a set of four genes predicts future relapse of primary Wilms tumors with high accuracy, independent of anaplasia.

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  • (PMID = 15805255.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01-CA89279
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Protein-beta
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96. Seethala RR: An update on grading of salivary gland carcinomas. Head Neck Pathol; 2009 Mar;3(1):69-77
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  • Mucoepidermoid carcinomas are graded in a three tier fashion based on a constellation of features including cystic component, border, mitoses, anaplasia, and perineural invasion among others.

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  • (PMID = 20596994.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
  • [Other-IDs] NLM/ PMC2807532
  • [Keywords] NOTNLM ; Adenoid cystic carcinoma / Carcinoma ex pleomorphic adenoma / Grading / High grade transformation / Mucoepidermoid carcinoma / Salivary carcinoma
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97. Collins BT, Janney CG, Ong M, Cortese C: Fine needle aspiration biopsy of monophasic spindle synovial sarcoma of lung with fluorescence in situ hybridization identification of t(x;18) translocation: a case report. Acta Cytol; 2009 Jan-Feb;53(1):105-8
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  • There was no anaplasia or specific mesenchymal differentiation.

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  • (PMID = 19248564.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Vimentin
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98. Parnell PG, Crossland JP, Beattie RM, Dewey MJ: Frequent Harderian gland adenocarcinomas in inbred white-footed mice (Peromyscus leucopus). Comp Med; 2005 Aug;55(4):382-6
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

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  • The periocular tumors appeared to be highly malignant, with elevated mitotic indices, marked anaplasia, and metastases to regional lymph nodes and lungs.

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  • (PMID = 16158914.001).
  • [ISSN] 1532-0820
  • [Journal-full-title] Comparative medicine
  • [ISO-abbreviation] Comp. Med.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / RR14279
  • [Publication-type] Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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99. Pinnix ZK, Miller LD, Wang W, D'Agostino R Jr, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, Torti SV, Torti FM: Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med; 2010 Aug 4;2(43):43ra56
Hazardous Substances Data Bank. IRON, ELEMENTAL .

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  • Ferroportin protein is also present in normal human mammary tissue and markedly decreased in breast cancer tissue, with the highest degree of anaplasia associated with lowest ferroportin expression.
  • Gene expression profiles in breast cancers from >800 women reveal that decreased ferroportin gene expression is associated with a significant reduction in metastasis-free and disease-specific survival that is independent of other breast cancer risk factors.

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  • (PMID = 20686179.001).
  • [ISSN] 1946-6242
  • [Journal-full-title] Science translational medicine
  • [ISO-abbreviation] Sci Transl Med
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK071892; United States / NIDDK NIH HHS / DK / R37 DK042412; United States / NIDDK NIH HHS / DK / R37DK42412
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimicrobial Cationic Peptides; 0 / Cation Transport Proteins; 0 / HAMP protein, human; 0 / Hamp1 protein, mouse; 0 / Hepcidins; 0 / metal transporting protein 1; E1UOL152H7 / Iron
  • [Other-IDs] NLM/ NIHMS476480; NLM/ PMC3734848
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100. Kim DY, Joo JK, Park YK, Ryu SY, Kim YJ, Kim SK: Prognostic factors in gastric carcinoma with peritoneal dissemination. Acta Chir Belg; 2006 Nov-Dec;106(6):665-8
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  • RESULTS: Based on the grade of anaplasia, 76 (21.8%) were differentiated and 272 (78.2%) were undifferentiated.

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  • (PMID = 17290691.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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