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[Title] [Anal cancer in Iceland 1987-2003. A population based study].

[Transliterated title] Carcinoma ani á Islandi 1987-2003 -- lýethgrundueth rannsókn.

OBJECTIVE: Anal cancer is a rare disease.

The aim of this study was to describe anal cancer in Iceland in 1987-2003 with respect to incidence, histologic type, treatment, recurrence rate and survival.

MATERIAL AND METHODS: This is a retrospective study in which all malignant anal tumours diagnosed in Iceland in the period 1987-2003 were reviewed with respect to patient outcome.

This is a nationwide, population-based study of malignant tumours of the anal region.

RESULTS: From 1987-2003 thirty-eight patients were diagnosed with anal cancer, 28 females and 10 males.

The average age at diagnosis was 63.4 years.

Age standardized incidence rates for anal cancer in Iceland were 0.3 (+/-0.2) of 100.000 males and 0.9 (+/-0.4) of 100.000 females.

Most patients had squamous cell carcinoma (n=30).

The remaining histologic types were malignant melanoma (n=3), adenosquamous carcinoma (n=1), adenocarcinoma (n=1), GIST (n=1) and undifferentiated carcinoma (n=2).

The duration of symptoms before diagnosis ranged from 2 weeks to 96 months (mean value 3.5 months).

Twelve patients had recurrent cancer.

The mean value of the time from diagnosis of the primary to the recurrent cancer was 15.6 months (range, 5.9-117).

Sixteen patients remain with disease and ten have died of anal cancer.

The five year survival rate for patients diagnosed in the years 1987 to 1998 is 75% but cancer-specific survival is 82%.

CONCLUSION: Age-standardized incidence for anal cancer in Iceland is similar to other regions.

Average age at diagnosis, male-female ratio and prognosis is similar to reports in other studies.

The proportion of adenocarcinoma of the anus is lower in Iceland than elsewhere.

[MeSH-major] Anus Neoplasms / epidemiology

[MeSH-minor] Adenocarcinoma / epidemiology. Aged. Carcinoma / epidemiology. Carcinoma, Adenosquamous / epidemiology. Carcinoma, Squamous Cell / epidemiology. Defecation. Female. Gastrointestinal Hemorrhage / etiology. Humans. Iceland / epidemiology. Incidence. Male. Melanoma / epidemiology. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Pain / etiology. Pruritus / epidemiology. Retrospective Studies. Survival Analysis

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(PMID = 16741319.001).

[ISSN] 0023-7213

[Journal-full-title] Læknablađiđ

[ISO-abbreviation] Laeknabladid

[Language] ice

[Publication-type] English Abstract; Journal Article

[Publication-country] Iceland

   

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[Title] High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia.

Anal intraepithelial neoplasia (AIN) is the likely precursor to anal cancer.

AIN is associated with human papillomavirus (HPV) infection, and HPV-associated genomic instability may play an important role in the progression of squamous intraepithelial neoplasia to cancer.

HPV16 DNA integration or rearrangement correlated with CNAs in host cell DNA (P = 0.007).

[MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Genome, Viral. Papillomaviridae / physiology. Virus Integration

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(PMID = 16186736.001).

[ISSN] 1525-4135

[Journal-full-title] Journal of acquired immune deficiency syndromes (1999)

[ISO-abbreviation] J. Acquir. Immune Defic. Syndr.

[Language] eng

[Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / R01CA54053; United States / NCI NIH HHS / CA / U01 CA66529; United States / NCI NIH HHS / CA / U01 CA70019

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

[Publication-country] United States

   

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BACKGROUND: This study evaluated the performance of oral brush biopsies using standard morphological analysis and haematoxylin and eosin (HE) staining for detecting oral squamous cell carcinomas and their respective precursor lesions PATIENTS AND METHODS: Brush biopsies were obtained in 169 consecutive patients who underwent routine biopsies and histological examination for clinically suspicious oral lesions.

RESULTS: Despite a sufficient number of cells, a definite cytological diagnosis could not be established in six cases.

Thus, this technique should not be used for diagnostic proof or to exclude malignant cells in a lesion suspicious for cancer.

[MeSH-major] Biopsy / methods. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology

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(PMID = 18214406.001).

[ISSN] 1433-0458

[Journal-full-title] HNO

[ISO-abbreviation] HNO

[Language] ger

[Publication-type] English Abstract; Evaluation Studies; Journal Article

[Publication-country] Germany

   

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[Title] HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis.

BACKGROUND AND AIMS: Majority of cases of anal squamous cell carcinoma are human papilloma virus (HPV)-induced and result from anal intraepithelial neoplasia (AIN).

This study was conducted to examine methods which may enable the routine diagnosis of HPV-induced changes in the anal rim and the consequences of such detection especially in view of a more sensitive diagnosis of AIN.

METHODS: The study included biopsy samples from 87 patients who had been diagnosed with the following disease patterns: 47 invasive anal carcinoma, 33 AIN of varying severity and seven condylomatous lesions.

RESULTS: In 38 of 47 cases of anal carcinoma, HPV DNA could be detected via PCR (80.9%), the majority of which were HPV 16 (33/38=86.8%).

DISCUSSION: In our series, the clinical diagnosis of the invasive anal carcinoma had a high sensitivity of 93.6%, with a specificity of 80%.

In this situation, especially with high-risk patients, our findings recommend anal HPV screening in combination with anal cytology and anoscopy.

CONCLUSION: Based on our results, we urgently recommend for any histological report on excision of anal lesions to include a statement whether histological markers of HPV infection were detected.

[MeSH-major] Alphapapillomavirus / genetics. Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. DNA, Viral / analysis

[MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retrospective Studies

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(PMID = 15864603.001).

[ISSN] 0179-1958

[Journal-full-title] International journal of colorectal disease

[ISO-abbreviation] Int J Colorectal Dis

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / DNA, Viral

   

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[Title] Radiation therapy advances for treatment of anal cancer.

Radiation therapy (RT) is established as the primary treatment of squamous cell carcinoma of the anus.

[MeSH-major] Anus Neoplasms / radiotherapy

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(PMID = 20064294.001).

[ISSN] 1540-1405

[Journal-full-title] Journal of the National Comprehensive Cancer Network : JNCCN

[ISO-abbreviation] J Natl Compr Canc Netw

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 39

   

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[MeSH-major] Antibodies, Monoclonal / chemistry. Antibodies, Monoclonal / pharmacokinetics. Carcinoma, Squamous Cell / metabolism. Chelating Agents / chemistry. Deferoxamine / analogs & derivatives. Isothiocyanates / chemistry. Positron-Emission Tomography / methods. Radioisotopes / pharmacokinetics. Zirconium / pharmacokinetics

[MeSH-minor] Animals. Cell Line, Tumor. Female. Humans. Isotope Labeling / methods. Metabolic Clearance Rate. Mice. Mice, Nude. Organ Specificity. Radioimmunodetection / methods. Radiopharmaceuticals / chemical synthesis. Radiopharmaceuticals / pharmacokinetics. Tissue Distribution

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(PMID = 19763566.001).

[ISSN] 1619-7089

[Journal-full-title] European journal of nuclear medicine and molecular imaging

[ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / 4-isothiocyanatobenzyl-desferrioxamine; 0 / Antibodies, Monoclonal; 0 / Chelating Agents; 0 / Isothiocyanates; 0 / Radioisotopes; 0 / Radiopharmaceuticals; C6V6S92N3C / Zirconium; J06Y7MXW4D / Deferoxamine

[Other-IDs] NLM/ PMC2816257

   

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[Title] Infrared coagulator ablation of high-grade anal squamous intraepithelial lesions in HIV-negative males who have sex with males.

PURPOSE: The incidence of anal squamous carcinoma in males who have sex with males is rising.

We reported that infrared coagulation of high-grade squamous intraepithelial lesions in HIV-positive males who have sex with males yielded a recurrence rate after the first ablation of 65 percent and 58 percent after a second ablation.

METHODS: We performed a retrospective review of medical records on HIV-negative males who have sex with males who had infrared coagulation ablation of anal high-grade squamous intraepithelial lesions.

Recurrent high-grade squamous intraepithelial lesions were retreated.

HIV-positive patients were twice as likely to have lesions persist and 1.7 times more likely to develop a recurrent high-grade squamous intraepithelial lesion.

No patient developed squamous-cell carcinoma, anal stenosis, or had a serious complication.

CONCLUSIONS: Infrared coagulation is a safe and effective office-based procedure for treating anal high-grade squamous intraepithelial lesions.

Although recurrence was high after the first infrared coagulation, repeated treatment led to resolution of high-grade squamous intraepithelial lesions.

[MeSH-major] Anus Neoplasms / surgery. Carcinoma, Squamous Cell / surgery. HIV Seronegativity. Homosexuality, Male. Infrared Rays / therapeutic use. Light Coagulation / methods. Precancerous Conditions / surgery

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(PMID = 17380365.001).

[ISSN] 0012-3706

[Journal-full-title] Diseases of the colon and rectum

[ISO-abbreviation] Dis. Colon Rectum

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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No evidence of a correlation was found between adduct levels in normal tissues and primary tumor biopsies.

[MeSH-minor] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / radiotherapy. Combined Modality Therapy. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / radiotherapy. Humans. Leukocyte Count. Mouth Mucosa / cytology. Predictive Value of Tests

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(PMID = 17639394.001).

[ISSN] 0344-5704

[Journal-full-title] Cancer chemotherapy and pharmacology

[ISO-abbreviation] Cancer Chemother. Pharmacol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA Adducts; Q20Q21Q62J / Cisplatin

[Other-IDs] NLM/ PMC2270367

   

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This fluorescent molecular probe consists of a thiol reaction moiety bound to a coumarin fluorophore.

[MeSH-major] Carcinoma, Squamous Cell / chemistry. Fluorescent Dyes / chemistry. Sulfhydryl Compounds / analysis. Tongue Neoplasms / chemistry

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(PMID = 20473559.001).

[ISSN] 1573-4994

[Journal-full-title] Journal of fluorescence

[ISO-abbreviation] J Fluoresc

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Fluorescent Dyes; 0 / Sulfhydryl Compounds

   

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[Title] Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.

Human papilloma virus (HPV) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ASCC) but is not sufficient for tumour progression.

This carcinoma is poorly understood at the molecular level.

[MeSH-major] Anus Neoplasms / genetics. Biomarkers, Tumor / genetics. Carcinoma, Squamous Cell / genetics. Mutation. Papillomaviridae / isolation & purification. Proto-Oncogene Proteins c-akt / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. Tumor Suppressor Protein p53 / genetics

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[Copyright] (c) 2007 Wiley-Liss, Inc.

(PMID = 17721920.001).

[ISSN] 1097-0215

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2

   

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RESULTS: Between 1989 and 1998, 46 patients underwent pelvi-perineal reconstruction with RAM flaps after radical pelvic surgery for carcinoma of the cervix (n=22), anal carcinoma (n=11), rectal carcinoma (n=7), or other pelvic tumours types (n=6).

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(PMID = 16126359.001).

[ISSN] 0748-7983

[Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

[ISO-abbreviation] Eur J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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Binding of IRDye 800CW EGF to intact A431 human epidermoid carcinoma cells was quantified in a microplate assay.

This is the first study to directly correlate targeting agent signal strength in whole cell binding, In-Cell Western, and in vivo near-infrared imaging.

[MeSH-major] Carcinoma, Squamous Cell / diagnosis. Epidermal Growth Factor

[MeSH-minor] Animals. Cell Line, Tumor. Chromatography, Gel. Chromatography, High Pressure Liquid. Coloring Agents. Humans. Indicators and Reagents. Mice. Mice, Nude. Mice, SCID. Receptor, Epidermal Growth Factor. Sensitivity and Specificity. Spectrometry, Fluorescence / methods. Transplantation, Heterologous

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[Cites] Nat Rev Mol Cell Biol. 2002 Aug;3(8):600-14 [12154371.001]

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(PMID = 17188228.001).

[ISSN] 0003-2697

[Journal-full-title] Analytical biochemistry

[ISO-abbreviation] Anal. Biochem.

[Language] eng

[Grant] United States / NCI NIH HHS / CA / R01 CA106584

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Coloring Agents; 0 / Indicators and Reagents; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor

[Other-IDs] NLM/ NIHMS16673; NLM/ PMC1866276

   

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Cancer incidence rates were race specific and were adjusted for age; these were compared with national rates using logistic regression to assess predictors of NADC development.

The most frequent NADCs were skin carcinomas (basal cell and squamous cell), Hodgkin disease, and anal carcinoma.

The results showed that there were higher rates of melanoma, basal and squamous cell skin carcinomas, anal carcinoma, prostate carcinoma, and Hodgkin disease among the HIV-infected cohort compared with age-adjusted rates for the general United States population.

A low CD4 nadir or CD4 count at diagnosis (< 200 cells/mL) was not predictive of NADCs.

CONCLUSIONS: The most frequent NADCs were primary skin malignancies.

Melanoma, basal and squamous cell skin carcinomas, anal carcinoma, prostate carcinoma, and Hodgkin disease occurred at higher rates among HIV-infected individuals.

[MeSH-minor] Adult. Age Distribution. Aged. Analysis of Variance. Cohort Studies. Comorbidity. Female. HIV Infections / diagnosis. HIV Infections / epidemiology. Humans. Incidence. Male. Middle Aged. Multivariate Analysis. Probability. Prognosis. Retrospective Studies. Risk Factors. Severity of Illness Index. Sex Distribution. Survival Analysis. United States / epidemiology

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(PMID = 16104038.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

   

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[Title] Comparative shotgun proteomics using spectral count data and quasi-likelihood modeling.

Shotgun proteomics provides the most powerful analytical platform for global inventory of complex proteomes using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and allows a global analysis of protein changes.

Nevertheless, sampling of complex proteomes by current shotgun proteomics platforms is incomplete, and this contributes to variability in assessment of peptide and protein inventories by spectral counting approaches.

Thus, shotgun proteomics data pose challenges in comparing proteomes from different biological states.

We developed an analysis strategy using quasi-likelihood Generalized Linear Modeling (GLM), included in a graphical interface software package (QuasiTel) that reads standard output from protein assemblies created by IDPicker, an HTML-based user interface to query shotgun proteomic data sets.

This approach was compared to four other statistical analysis strategies: Student t test, Wilcoxon rank test, Fisher's Exact test, and Poisson-based GLM.

We analyzed the performance of these tests to identify differences in protein levels based on spectral counts in a shotgun data set in which equimolar amounts of 48 human proteins were spiked at different levels into whole yeast lysates.

Both GLM approaches and the Fisher Exact test performed adequately, each with their unique limitations.

We subsequently compared the proteomes of normal tonsil epithelium and HNSCC using this approach and identified 86 proteins with differential spectral counts between normal tonsil epithelium and HNSCC.

We selected 18 proteins from this comparison for verification of protein levels between the individual normal and tumor tissues using liquid chromatography-multiple reaction monitoring mass spectrometry (LC-MRM-MS).

This analysis confirmed the magnitude and direction of the protein expression differences in all 6 proteins for which reliable data could be obtained.

Our analysis demonstrates that shotgun proteomic data sets from different tissue phenotypes are sufficiently rich in quantitative information and that statistically significant differences in proteins spectral counts reflect the underlying biology of the samples.

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[ErratumIn] J Proteome Res. 2010 Nov 5;9(11):6090

(PMID = 20586475.001).

[ISSN] 1535-3907

[Journal-full-title] Journal of proteome research

[ISO-abbreviation] J. Proteome Res.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / U24 CA126479; United States / NCI NIH HHS / CA / 1U24CA126479

[Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Proteins

[Other-IDs] NLM/ PMC2920032

   

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[Title] Epidermal growth factor receptor expression in anal canal carcinoma.

Most anal canal carcinomas (ACCs) are squamous cell carcinomas (SCCs).

Therefore, we obtained archived pathology samples from ACC biopsies and examined the frequency and level of expression of EGFR and other cell surface and cell cycle markers.

[MeSH-major] Anal Canal / pathology. Anus Neoplasms / metabolism. Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / metabolism. Receptor, Epidermal Growth Factor / biosynthesis

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(PMID = 15923158.001).

[ISSN] 0002-9173

[Journal-full-title] American journal of clinical pathology

[ISO-abbreviation] Am. J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2

   

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[MeSH-major] Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Receptor, PAR-2 / metabolism. Uterine Cervical Neoplasms / genetics. Uterine Cervical Neoplasms / pathology

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(PMID = 18937843.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / RNA, Messenger; 0 / Receptor, PAR-2

[Other-IDs] NLM/ PMC2587477

   

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[Title] Effective treatment of anal cancer in the elderly with low-dose chemoradiotherapy.

Chemoradiotherapy (CRT) is accepted as the standard initial treatment for squamous cell anal cancer.

This paper reports the results of a modified regimen for this group of patients.

In all, 16 patients with biopsy-proven squamous cell carcinoma of the anal canal or margin and performance status or co-morbidity precluding the use of full-dose CRT were included in this protocol.

Patients received a dose of 30 Gy to the gross tumour volume plus 3 cm margin in all directions.

Only one patient experienced any grade 3 toxicity (skin).

This is a well-tolerated regimen for elderly/poor performance patients with anal cancer, which can achieve high rates of local control and survival.

[MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Anus Neoplasms / drug therapy. Anus Neoplasms / radiotherapy. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Fluorouracil / therapeutic use. Frail Elderly

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(PMID = 15798772.001).

[ISSN] 0007-0920

[Journal-full-title] British journal of cancer

[ISO-abbreviation] Br. J. Cancer

[Language] eng

[Publication-type] Clinical Trial; Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil

[Other-IDs] NLM/ PMC2361984

   

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[Title] The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.

Due to the increasing incidence of anal cancer in HIV-positive men who have sex with men, and the potential to detect and treat high-grade anal dysplasia--the putative anal cancer precursor--we have introduced an anal cytology screening service.

Patients with abnormal anal cytology have follow-up high-resolution anoscopy (HRA) with biopsy of lesions clinically suspicious for high-grade dysplasia.

One hundred and sixty-four (67%) men had abnormal anal cytology, and 93 of them had follow-up HRA and anal biopsy.

The positive predictive value for any anal cytological abnormality to predict any degree of anal dysplasia was 95.7+/-2.1%, and for any anal cytological abnormality to predict high-grade anal dysplasia was 55.9+/-5.1%.

Abnormal anal cytology was highly predicative of anal dysplasia on biopsy.

[MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma, Squamous Cell. HIV Infections / complications. Homosexuality, Male

[MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / epidemiology. Adult. Aged. Biopsy. Cytological Techniques. Humans. Male. Middle Aged. Predictive Value of Tests. Prevalence

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(PMID = 17331275.001).

[ISSN] 0956-4624

[Journal-full-title] International journal of STD & AIDS

[ISO-abbreviation] Int J STD AIDS

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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Cluster analysis was applied to find any relationship between spectral shape and lesion type or cell layer.

No clustering with regard to lesion type or cell layer was observed.

Raman spectra allowed for reliable classification into cell layers, but differences between lesion types were not significant in this study.

[MeSH-minor] Carcinoma, Squamous Cell / pathology. Cluster Analysis. Connective Tissue / pathology. Epithelium / pathology. Freeze Drying. Humans. Keratins / metabolism. Mouth Neoplasms / pathology

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[ISSN] 0268-8921

[Journal-full-title] Lasers in medical science

[ISO-abbreviation] Lasers Med Sci

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 68238-35-7 / Keratins

   

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[Title] Raman spectroscopy in head and neck cancer.

In recent years there has been much interest in the use of optical diagnostics in cancer detection.

Early diagnosis of cancer affords early intervention and greatest chance of cure.

Raman has been used successfully in key health areas such as cardiovascular diseases, and dental care but there is a paucity of literature on Raman spectroscopy in Head and Neck cancer.

Following the introduction of health care targets for cancer, and with an ever-aging population the need for rapid cancer detection has never been greater.

Raman spectroscopy could confer great patient benefit with early, rapid and accurate diagnosis.

It could reduce the need for whole pathological specimen examination, in theatre it could help to determine margin status, and finally peripheral blood diagnosis may be an achievable target.

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(PMID = 20923567.001).

[ISSN] 1758-3284

[Journal-full-title] Head & neck oncology

[ISO-abbreviation] Head Neck Oncol

[Language] ENG

[Grant] United Kingdom / Cancer Research UK / /

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] England

[Other-IDs] NLM/ PMC2958871

   

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[Title] Effects of ROCK inhibitor, Y-27632, on adhesion and mobility in esophageal squamous cell cancer cells.

However, little is known the effect of ROCK on cell adhesion and mobility in esophageal squamous cell cancer (ESCC), one of the most diagnosed cancers in China.

All these findings indicate that ROCK signaling pathway plays an important role in cell adhesion and mobility, suggesting that it may be used as a potential target for therapy of ESCC.

[MeSH-major] Amides / pharmacology. Carcinoma, Squamous Cell / pathology. Cell Movement / drug effects. Esophageal Neoplasms / pathology. Protein Kinase Inhibitors / pharmacology. Pyridines / pharmacology. rho-Associated Kinases / antagonists & inhibitors

[MeSH-minor] Cell Adhesion / drug effects. Cell Line, Tumor. Humans

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(PMID = 19649725.001).

[ISSN] 1573-4978

[Journal-full-title] Molecular biology reports

[ISO-abbreviation] Mol. Biol. Rep.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Amides; 0 / Protein Kinase Inhibitors; 0 / Pyridines; 138381-45-0 / Y 27632; EC 2.7.11.1 / rho-Associated Kinases

   

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[MeSH-major] Biomarkers, Tumor / analysis. Biopsy / methods. Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology. Tenascin / analysis

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(PMID = 17111122.001).

[ISSN] 1432-6981

[Journal-full-title] Clinical oral investigations

[ISO-abbreviation] Clin Oral Investig

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Tenascin

   

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[Title] Apoptotic count as a guide for histological grading of carcinoma esophagus: a light microscopic study.

AIMS: The study aims to find out if a correlation between apoptotic count and histological grading exists in squamous cell carcinoma of the esophagus, and also to review the literature on such a relationship in the context of some other tumors.

SETTINGS AND DESIGN: Cases of squamous cell carcinoma of the esophagus who presented at a tertiary care center over a period of one year were reviewed.

MATERIALS AND METHODS: The endoscopic biopsy specimens of 56 patients of squamous cell carcinoma of esophagus were fixed in 10% buffered formalin, processed for routine paraffin sections, sections taken, stained by hematoxylin and eosin and examined under light microscope, using 40× objective and 10× eyepiece.

CONCLUSIONS: Grading of squamous cell carcinoma of esophagus, solely on the basis of apoptotic count can be used in the first place or to corroborate conventional histological grading done on the basis of morphology.

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(PMID = 21938242.001).

[ISSN] 0974-2727

[Journal-full-title] Journal of laboratory physicians

[ISO-abbreviation] J Lab Physicians

[Language] eng

[Publication-type] Journal Article

[Publication-country] India

[Other-IDs] NLM/ PMC3167958

[Keywords] NOTNLM ; Apoptotic count / histological grading / squamous cell carcinoma esophagus

   

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[Title] Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.

BACKGROUND: Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM).

There is a paucity of data published on the progression of high-grade AIN to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma.

OBJECTIVES: To search for anal carcinoma and AIN in a large series of HIV-positive MSM, to assess treatment response of anal carcinoma, and to analyse lesional HPV spectrum of anal cancers.

METHODS: Detection of anal carcinoma and AIN was performed using cytology, high-resolution anoscopy, and histology in case of abnormal findings.

Additionally, HPV analyses for 36 high- and low-risk α-HPV types were performed in patients with anal carcinoma.

Of these, 116 (26·0%) patients had normal findings, 163 (36·5%) had low-grade AIN, 156 (35·0%) had high-grade AIN, and 11 (2·5%) had anal carcinoma as evidenced by the highest grade of cytology/histology.

Five patients with anal cancer, who had refused treatment of their precancerous lesions, had progressed from high-grade AIN to invasive cancer within a median time of 8·6 months.

All anal cancers carried high-risk α-HPV types.

All five squamous cell carcinomas (SCCs) of the anal canal were HPV16 positive.

In contrast, only one of the four anal margin SCCs were HPV16 positive (HPV31, HPV33 and HPV33 + HPV68 were found in the other three anal margin SCCs).

In contrast to the cancer biopsies, a broad spectrum of surface high- and low-risk HPV types was found in anal swabs of the patients.

Surgical excision resulted in long-term disease control of all anal margin carcinomas, whereas combined chemoradiotherapy in carcinomas of the anal canal was associated with high recurrence rates, high toxicity, and high mortality.

CONCLUSIONS: Anal carcinoma and AIN are frequent in HIV-positive men, even in patients participating in anal cancer prevention programmes.

High-grade dysplasia in these patients can progress to invasive cancer within a short period of time.

Anal margin carcinoma and anal canal carcinoma differ substantially in their lesional HPV spectrum, prognosis and treatment response.

[MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. HIV Seropositivity / complications. Papillomaviridae / isolation & purification

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[Copyright] © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.

(PMID = 20184584.001).

[ISSN] 1365-2133

[Journal-full-title] The British journal of dermatology

[ISO-abbreviation] Br. J. Dermatol.

[Language] eng

[Databank-accession-numbers] ClinicalTrials.gov/ NCT00365729

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antineoplastic Agents

   

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In this regard, two novel sensitive and selective strategies are proposed here to quantify cisplatin-DNA adducts generated in Drosophila melanogaster larvae and in head and neck squamous cell carcinoma cultures.

Two different strategies, based on isotope dilution analysis (IDA), have been attempted and evaluated for quantification: species-unspecific (the postcolumn addition of a 194Pt-enriched solution) and the species-specific (by means of a synthesized isotopically enriched cisplatin (194Pt) adduct).

Species-specific spiking before enzymatic digestion provided accurate and precise analytical results to clearly differentiate between Drosophila samples and carcinoma cell cultures exposed to different cisplatin concentrations.

[MeSH-minor] Animals. Base Sequence. Cell Line, Tumor. Drosophila melanogaster / metabolism. Humans. Indicator Dilution Techniques. Isotopes. Mass Spectrometry. Oligodeoxyribonucleotides / genetics. Oligodeoxyribonucleotides / metabolism

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(PMID = 19886652.001).

[ISSN] 1520-6882

[Journal-full-title] Analytical chemistry

[ISO-abbreviation] Anal. Chem.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / DNA Adducts; 0 / Isotopes; 0 / Oligodeoxyribonucleotides; Q20Q21Q62J / Cisplatin

   

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[Title] [Treatment of patients with squamous cell carcinoma of the anal canal in the last 20 years in a gastroenterology hospital].

[Transliterated title] El tratamiento de los pacientes con carcinoma epidermoide del canal anal en los últimos 20 años en nuestro hospital.

Anal cancers compromise only 1.5% of all digestive tumors.

OBJECTIVE: To collect and analyze clinical data from the medical records of all consecutive patients with squamous cell carcinoma of the anal canal (SCCAC) treated by the Oncology Section in 20 years.

[MeSH-major] Anus Neoplasms / therapy. Carcinoma, Squamous Cell / therapy

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(PMID = 16127985.001).

[ISSN] 0300-9033

[Journal-full-title] Acta gastroenterologica Latinoamericana

[ISO-abbreviation] Acta Gastroenterol. Latinoam.

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Argentina

   

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[Title] Novel diagnostic methods for early-stage squamous cell carcinoma of the anal canal successfully resected by endoscopic submucosal dissection.

[MeSH-major] Anus Neoplasms / diagnosis. Carcinoma, Squamous Cell / diagnosis. Colonoscopy / methods. Dissection / methods. Intestinal Mucosa / surgery

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(PMID = 19866431.001).

[ISSN] 1438-8812

[Journal-full-title] Endoscopy

[ISO-abbreviation] Endoscopy

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Germany

   

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Related average imbalance patterns were found for clinically distinct entities, e.g. hepatocellular carcinomas (ca.) and ductal breast ca., as well as for histologically related entities (squamous cell ca. of different sites).

[MeSH-major] Carcinoma / genetics. Chromosome Aberrations. Chromosome Mapping

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(PMID = 18088415.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't

[Publication-country] England

[Other-IDs] NLM/ PMC2225423

   

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This article gives an overview on different current strategies of assay-based response evaluation in head and neck squamous cell carcinomas (HNSCC) and critically summarizes their role and needs for future clinical evaluation.

Moreover, the outcome is difficult to predict due to heterogeneity of a tumor's response, impaired late functional outcome, and increased late toxicity if simultaneously applied to radiation.

Unfortunately, predictive information on response characteristics of a given tumor before starting the therapy is not available in daily routine, although heterogeneity in response of a given tumor entity to treatments has been known for decades.

[MeSH-major] Carcinoma, Squamous Cell / therapy. Combined Modality Therapy / methods. Decision Making. Head and Neck Neoplasms / therapy

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(PMID = 20052589.001).

[ISSN] 1434-4726

[Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

[ISO-abbreviation] Eur Arch Otorhinolaryngol

[Language] eng

[Publication-type] Evaluation Studies; Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Antineoplastic Agents

   

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[Title] Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD.

BACKGROUND: The integrin alphavbeta3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches.

Moreover, using the A431 human squamous cell carcinoma model we demonstrate that this approach is sensitive enough to visualize alphavbeta3 expression resulting exclusively from the tumor vasculature.

[MeSH-minor] Animals. Blotting, Western. Carcinoma, Squamous Cell / radionuclide imaging. Humans. Immunohistochemistry. Melanoma / radionuclide imaging. Mice. Neoplasms / blood supply. Neoplasms / pathology. Neovascularization, Pathologic. Positron-Emission Tomography. Sensitivity and Specificity. Skin Neoplasms / radionuclide imaging. Transplantation, Heterologous

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(PMID = 15783258.001).

[ISSN] 1549-1676

[Journal-full-title] PLoS medicine

[ISO-abbreviation] PLoS Med.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Integrin alphaVbeta3; 0 / Peptides, Cyclic; 0 / fluorogalacto-RGD; X2RN3Q8DNE / Galactose

[Other-IDs] NLM/ PMC1069665

   

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[Title] The effect of intensity-modulated radiotherapy and high dose rate brachytherapy on acute and late radiotherapy-related adverse events following chemoradiotherapy of anal cancer.

BACKGROUND AND PURPOSE: To investigate acute and late radiotherapy-related adverse events following intensity-modulated radiotherapy (IMRT) and high dose rate (HDR) brachytherapy of anal cancer.

MATERIALS AND METHODS: Fifty-nine consecutive patients treated by chemoradiotherapy for anal squamous cell cancer were evaluated for acute and late radiotherapy-related adverse events.

RESULTS: A significant reduction in skin and mucosal eruptions in the female genital area (P=0.04) and in radiotherapy-associated > grade 2 diarrhoea (P=0.004) was observed in patients treated by IMRT.

A correlation between the equivalent dose in 2Gy fractions (EQD2) at the wall of anal canal opposite to the tumour and radiation proctitis was observed.

CONCLUSIONS: IMRT significantly reduces acute radiotherapy-associated adverse events in patients treated by chemoradiotherapy for anal cancer.

[MeSH-major] Anus Neoplasms / radiotherapy. Brachytherapy / adverse effects. Carcinoma, Squamous Cell / radiotherapy. Radiotherapy, Intensity-Modulated / adverse effects

[MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / drug therapy. Carcinoma, Basal Cell / radiotherapy. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Radiation Injuries. Radiotherapy Dosage

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(PMID = 18501454.001).

[ISSN] 0167-8140

[Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

[ISO-abbreviation] Radiother Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Ireland

   

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[Title] Staging anal cancer: prospective comparison of transanal endoscopic ultrasound and magnetic resonance imaging.

PURPOSE: The staging of anal cancer is extremely important for therapy and prognosis.

METHODS: Forty-five anal cancer patients underwent endoscopic ultrasound and magnetic resonance imaging.

Cancer patients were correctly identified with 100% sensitivity (45/45) by endoscopic ultrasound and with 88.9% (40/45) sensitivity by magnetic resonance imaging.

[MeSH-major] Anus Neoplasms / diagnostic imaging. Anus Neoplasms / pathology. Endosonography. Magnetic Resonance Imaging. Neoplasm Staging / methods

[MeSH-minor] Adenocarcinoma / diagnostic imaging. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Biopsy, Needle. Carcinoma, Squamous Cell / diagnostic imaging. Carcinoma, Squamous Cell / pathology. Cohort Studies. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness / diagnostic imaging. Neoplasm Invasiveness / pathology. Prospective Studies. Sensitivity and Specificity

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(PMID = 19365694.001).

[ISSN] 1873-4626

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

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[Title] Episomal and integrated human papillomavirus type 16 loads and anal intraepithelial neoplasia in HIV-seropositive men.

OBJECTIVES: To assess levels of episomal and integrated human papillomavirus type 16 (HPV-16) loads in HIV-seropositive men who have sex with men (MSM) in anal infection and to study the association between episomal and integrated HPV-16 loads and anal intraepithelial neoplasia (AIN).

Overall, 135 (54.7%) men provided 665 HPV-16-positive anal samples.

RESULTS: The HPV-16 DNA forms in anal samples were characterized as episomal only in 627 samples (94.3%), mixed in 22 samples (3.3%) and integrated only in nine samples (1.4%).

HPV-16 episomal load [odds ratio (OR) = 1.5, 95% confidence interval (CI) 1.1-2.1], number of HPV types (OR = 1.4, 95% CI 1.1-1.8) and current smoking (OR = 4.8, 95% CI 1.3-18.6) were associated with high-grade AIN (AIN-2,3) after adjusting for age and CD4 cell counts.

[MeSH-major] Anus Neoplasms / immunology. Carcinoma, Squamous Cell / immunology. HIV Seropositivity / immunology. Human papillomavirus 16 / immunology. Papillomavirus Infections / immunology. Plasmids / immunology

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(PMID = 20706109.001).

[ISSN] 1473-5571

[Journal-full-title] AIDS (London, England)

[ISO-abbreviation] AIDS

[Language] eng

[Grant] Canada / Canadian Institutes of Health Research / /

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / DNA, Viral

[Investigator] Allaire G; Baril JG; Boissonnault M; Charest L; Charron MA; Coté S; Coté P; Coutlée F; de Pokomandy A; Dion H; Dufresne S; Falutz J; Fortin C; Franco EL; Ghattas G; Gilmore N; Gorska I; Hadjeres R; Junod P; Klein M; Lalonde R; Laplante F; Leblanc R; Legault D; Lessard B; Longpré D; McLeod J; Maziade JP; Murphy D; Nguyen VK; O'Brien R; Phaneuf D; Rouleau D; Routy JP; Szabo J; Tessier D; Thomas R; Toma E; Tremblay C; Trépanier JM; Trottier B; Tsoukas C; Turner H; Vezina S

   

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[Title] Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins.

We investigated mechanisms of acquired resistance to the EGFR TKI gefitinib by generating gefitinib-resistant (GR) A431 squamous cancer cells.

Inhibition of IGFIR signaling disrupted the association of IRS-1 with PI3K and restored the ability of gefitinib to downregulate PI3K/Akt signaling and to inhibit GR cell growth.

Addition of recombinant IGFBP-3 restored the ability of gefitinib to downregulate PI3K/Akt signaling and to inhibit cell growth.

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(PMID = 18568074.001).

[ISSN] 0021-9738

[Journal-full-title] The Journal of clinical investigation

[ISO-abbreviation] J. Clin. Invest.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA080195; United States / NCI NIH HHS / CA / P50 CA98131; United States / NCI NIH HHS / CA / P30 CA68485; United States / NCI NIH HHS / CA / R01 CA80195; United States / NCI NIH HHS / CA / P50 CA098131; United States / NCI NIH HHS / CA / K08 CA120060; United States / NCI NIH HHS / CA / P30 CA068485; United States / NCI NIH HHS / CA / R00 CA125892; United States / NCI NIH HHS / CA / K08 CA120060-01; United States / NCI NIH HHS / CA / P50 CA127003

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / IRS1 protein, human; 0 / Insulin Receptor Substrate Proteins; 0 / Insulin-Like Growth Factor Binding Protein 3; 0 / Insulin-Like Growth Factor Binding Protein 4; 0 / Insulin-Like Growth Factor Binding Proteins; 0 / Irs1 protein, mouse; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; 67763-96-6 / Insulin-Like Growth Factor I; 67763-97-7 / Insulin-Like Growth Factor II; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-3; EC 2.7.10.1 / Receptor, IGF Type 1; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; S65743JHBS / gefitinib

[Other-IDs] NLM/ PMC2430495