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1. Sweetser S, Alexander GL, Boardman LA: A case of Cronkhite-Canada syndrome presenting with adenomatous and inflammatory colon polyps. Nat Rev Gastroenterol Hepatol; 2010 Aug;7(8):460-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of Cronkhite-Canada syndrome presenting with adenomatous and inflammatory colon polyps.
  • In the past, he had experienced markedly increased levels of triglycerides and was being treated for this condition with a lipid-lowering agent.
  • DIAGNOSIS: Cronkhite-Canada syndrome.
  • Removal of all visible polyps from the anal verge to 25 cm endoscopically by snare polypectomy or with hot biopsy forceps, followed by subtotal colectomy with end-to-side ileorectostomy.
  • [MeSH-major] Anti-Inflammatory Agents / therapeutic use. Colon / pathology. Intestinal Polyposis / drug therapy. Intestinal Polyposis / pathology. Prednisone / therapeutic use

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  • (PMID = 20628344.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Histamine H2 Antagonists; 0 / Vitamins; VB0R961HZT / Prednisone
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2. Cai W, Zalis ME, Näppi J, Harris GJ, Yoshida H: Structure-analysis method for electronic cleansing in cathartic and noncathartic CT colonography. Med Phys; 2008 Jul;35(7):3259-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Electronic cleansing (EC) is an emerging method for segmentation of fecal material in CT colonography (CTC) that is used for reducing or eliminating the requirement for cathartic bowel preparation and hence for improving patients' adherence to recommendations for colon cancer screening.
  • In EC, feces tagged by an x-ray-opaque oral contrast agent are removed from the CTC images, effectively cleansing the colon after image acquisition.
  • Evaluation of the quality of the cleansing based on polyps and folds in a colon phantom, as well as on polyps in clinical cathartic and noncathartic CTC cases with fluid and stool tagging, showed that our structure-analysis cleansing method is significantly superior to that of our previous thresholding-based EC method.
  • [MeSH-minor] Algorithms. Colonic Polyps / diagnosis. Colonic Polyps / pathology. Colonoscopy / methods. Contrast Media / pharmacology. Feces. Humans. Imaging, Three-Dimensional. Models, Statistical. Normal Distribution. Phantoms, Imaging. Tomography, X-Ray Computed / methods. X-Rays

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  • (PMID = 18697551.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA095279; United States / NCI NIH HHS / CA / R56 CA095279; United States / NCI NIH HHS / CA / CA095279
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cathartics; 0 / Contrast Media
  • [Other-IDs] NLM/ PMC2809717
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3. Liu J, Yao J, Summers RM: Scale-based scatter correction for computer-aided polyp detection in CT colonography. Med Phys; 2008 Dec;35(12):5664-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Scale-based scatter correction for computer-aided polyp detection in CT colonography.
  • CT colonography (CTC) is a feasible and minimally invasive method for the detection of colorectal polyps and cancer screening.
  • Computer-aided detection (CAD) of polyps can improve consistency and sensitivity of virtual colonoscopy interpretation and reduce interpretation burden.
  • However, high-density orally administered contrast agents have scatter effects on neighboring tissues.
  • This pseudoenhancement phenomenon presents a problem for the application of computer-aided polyp detection, especially when polyps are submerged in the contrast agents.
  • By bringing a locally adaptive structure, object scale, into the correction framework, the region of neighboring tissues affected by contrast agents is automatically specified and adaptively changed in different parts of the image.
  • There were 50 colonoscopy-confirmed polyps measuring 6-9 mm.
  • Visual evaluation indicated that the method reduced CT attenuation of pseudoenhanced polyps to the usual polyp Hounsfield unit range without affecting luminal air regions.
  • For polyps submerged in contrast agents, the sensitivity of CAD with correction is increased 24% at a rate of ten false-positive detections per scan.
  • For all polyps within 6-9 mm, the sensitivity of the authors' CAD with scatter correction is increased 8% at a rate of ten false-positive detections per scan.
  • [MeSH-major] Colon / diagnostic imaging. Colonography, Computed Tomographic / methods. Diagnosis, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Algorithms. Automation. Colonoscopy / methods. Contrast Media / pharmacology. False Positive Reactions. Humans. Pattern Recognition, Automated. Polyps. Radiographic Image Interpretation, Computer-Assisted / methods. Reproducibility of Results. Scattering, Radiation

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  • (PMID = 19175123.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ NIHMS84353; NLM/ PMC2644449
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4. Gu GL, Wang SL, Wei XM, Bai L: Diagnosis and treatment of Gardner syndrome with gastric polyposis: a case report and review of the literature. World J Gastroenterol; 2008 Apr 7;14(13):2121-3
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  • [Title] Diagnosis and treatment of Gardner syndrome with gastric polyposis: a case report and review of the literature.
  • We present a case of a 23-year-old female patient with GS who presented with gastric polyposis and was successively treated with restorative proctocolectomy in combination with ileal pouch anal anastomosis (RPC/ IPAA), ileostomy, ileostomy closure operation, snare polypectomy during 8 mo.
  • After operation, the patient took oral traditional Chinese medicine pills made of Fructus mume and Bombyx batryticatu for about 6 mo.
  • [MeSH-major] Gardner Syndrome / diagnosis. Polyps / diagnosis. Stomach Diseases / diagnosis
  • [MeSH-minor] Adult. Animals. Bombyx / metabolism. Endoscopy. Female. Humans. Medicine, Chinese Traditional. Plant Extracts / therapeutic use. Proctocolectomy, Restorative / methods. Time Factors. Treatment Outcome

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  • (PMID = 18395919.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Plant Extracts
  • [Other-IDs] NLM/ PMC2701539
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5. Linguraru MG, Zhao S, Van Uitert RL, Liu J, Fletcher JG, Manduca A, Summers RM: CAD of colon cancer on CT colonography cases without cathartic bowel preparation. Conf Proc IEEE Eng Med Biol Soc; 2008;2008:2996-9
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  • [Title] CAD of colon cancer on CT colonography cases without cathartic bowel preparation.
  • Computer-aided diagnosis (CAD) systems must show sufficient versatility to produce robust analysis on a large variety of data.
  • In the case of colonography, CAD has not been designed to cope with the presence of stool, although labeling the stool with high contrast agents replaces the use of laxatives and reduces the patient discomfort.
  • This procedure introduces additional challenges for the diagnosis, such as poorly tagged stool, stool sticking to colonic walls, and heterogeneous stool (tagged stool mixed with air or untagged stool).
  • Colonoscopy data are automatically cleansed of residual stool to enhance the polyp appearance for improved diagnosis.
  • Results show stool removal accuracy on polyps which are partially or fully covered by stool.
  • The automatic detection of colon polyps using our CAD system on cathartic-free data improves considerably with the addition of the automatic stool removal module from 74% to 86% true positive (TP) rate at 6.4 false positives (FP)/case.
  • [MeSH-major] Colon / diagnostic imaging. Colon / pathology. Colonography, Computed Tomographic / methods. Diagnosis, Computer-Assisted / methods. Pattern Recognition, Automated / methods

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  • (PMID = 19163336.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CL999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Laxatives
  • [Other-IDs] NLM/ NIHMS69939; NLM/ PMC2630581
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6. Ranger-Moore J, Frank D, Lance P, Alberts D, Yozwiak M, Bartels HG, Einspahr J, Bartels PH: Karyometry in rectal mucosa of patients with previous colorectal adenomas. Anal Quant Cytol Histol; 2005 Jun;27(3):134-42
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  • OBJECTIVE: To determine whether karyometric measurements taken in biopsies from histologically normal-appearing rectal mucosa could serve as a biomarker for the risk of recurrence of polyps.
  • MATERIALS AND METHODS: Biopsies were taken from the rectal mucosa of cases with a prior history of colonic polyps at the baseline of the study.
  • In 57 cases recurrent polyps occurred (R cases); in 72 cases no recurrent disease was found at the end of the study (NR cases).
  • All cases with a prior history of colonic polyps showed a nuclear abnormality deviating from normal.
  • CONCLUSION: Measurement of a sample of 100 nuclei from the rectal mucosa will suggest, for approximately 10% of cases, that a high risk for recurrence of adenomatous polyps exists and, for a slightly lower proportion, confirm that the nuclei deviate only slightly from those from individuals with no history of colonic polyps.

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  • (PMID = 16121634.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-41108; United States / NCI NIH HHS / CA / CA-53877-09
  • [Publication-type] Clinical Trial; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cholagogues and Choleretics; 724L30Y2QR / Ursodeoxycholic Acid
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7. Gholam P, Autschbach F, Hartschuh W: Schistosomiasis in an HIV-positive patient presenting as an anal fissure and giant anal polyp. Arch Dermatol; 2008 Jul;144(7):950-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Schistosomiasis in an HIV-positive patient presenting as an anal fissure and giant anal polyp.
  • [MeSH-major] Anus Diseases / diagnosis. Fissure in Ano / diagnosis. HIV Infections. Schistosomiasis / diagnosis
  • [MeSH-minor] Adult. Animals. Anthelmintics / administration & dosage. Anthelmintics / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Polyps / diagnosis. Polyps / drug therapy. Polyps / pathology. Polyps / surgery. Praziquantel / administration & dosage. Praziquantel / therapeutic use. Schistosoma mansoni / isolation & purification. Viral Load


8. Shen R, Tao L, Xu Y, Chang S, Van Brocklyn J, Gao JX: Reversibility of aberrant global DNA and estrogen receptor-alpha gene methylation distinguishes colorectal precancer from cancer. Int J Clin Exp Pathol; 2009;2(1):21-33
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  • However, the significance of epigenetic changes for diagnosis and/or prognosis of colorectal cancer have not been established, although it has been extensively investigated.
  • Recently we have identified a new type of cancer cell called precancerous stem cells (pCSCs) and proposed that cancer may arise from a lengthy development process of tumor initiating cells (TICs) --> pCSCs --> cancer stem cells (CSCs) --> cancer, which is in parallel to histological changes of hyperplasia (TICs) --> precancer (pCSCs) --> carcinoma (CSCs/cancer cells), accompanied by clonal evolutionary epigenetic and genetic alterations.
  • Herein we show that global DNA hypomethylation and ER-alpha gene hypermethylation are progressively enhanced from hyperplastic polyps (HPs) --> adenomatous polyps (APs) --> adenomatous carcinoma (AdCa).
  • The aberrant methylation can be completely reversed in APs, but not in AdCa by a nonsteroidal anti-inflammatory drug (NSAID) celecoxib, which is a selective inhibitor of cyclooxygenase-2 (Cox-2), suggesting that the epigenetic alterations between colorectal precancer (AP) and cancer (AdCa) are fundamentally different in response to anti-cancer therapy.

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  • (PMID = 18830381.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; DNA methylation / Precancer / cancer progression / colorectal cancer / epigenetic / estrogen receptor-α / nonsteroidal anti-inflammatory drugs / tumor initiation
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9. Kuhne HP, Göller T, Schneider I, Bozkurt T, Becker HP: [Unclear per anum bleeding during pregnancy]. Chirurg; 2005 Aug;76(8):765-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rectoscopy showed the cause to be a polyp the size of a fingertip 9 cm from the anus.
  • About 1 year later, the same patient experienced sharp pains and anal bleeding during defecation.
  • [MeSH-major] Intestinal Polyps / diagnosis. Melena / etiology. Neuroendocrine Tumors / diagnosis. Pregnancy Complications / etiology. Pregnancy Complications, Neoplastic / diagnosis. Puerperal Disorders / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Disease Progression. Female. Humans. Infant, Newborn. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Staging. Pregnancy. Rectum / pathology. Rectum / surgery






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