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1. Moussata D, Nancey S, Lapalus MG, Prost B, Chavaillon A, Bernard G, Ponchon T, Saurin JC: Frequency and severity of ileal adenomas in familial adenomatous polyposis after colectomy. Endoscopy; 2008 Feb;40(2):120-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND STUDY AIMS: The high cumulative risk of colorectal cancer in patients with familial adenomatous polyposis (FAP) justifies prophylactic colectomy with either ileorectal (IRA) or ileal-pouch-anal anastomosis (IPAA).
  • All patients were followed with a standardized procedure including chromoscopy and biopsies of visible polyps.
  • RESULTS: In the IPAA group, 18/23 patients (78 %) presented with visible polyps [histology: 16 (70 %) had adenoma with low-grade dysplasia; 1 (4 %) had adenoma with high-grade dysplasia; 1 had normal mucosa].
  • The mean interval between colectomy and the diagnosis of adenoma was 4.7 +/- 3.3 years.
  • In the IRA group, 16/21 patients (77 %) presented visible polyps in the ileal mucosa [adenoma with low-grade dysplasia in 8 patients (38 %), with high-grade dysplasia in 2 (10 %), and lymphoid nodular hyperplasia in 6].
  • The mean interval between colectomy and adenoma diagnosis was significantly shorter in the IPAA than in the IRA group (4.76 +/- 3.3 vs. 16.4 +/- 8.5 years, P< 0.0001).


2. Fiducia G, Gandolfo L, Bosco V: [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases]. Chir Ital; 2008 Mar-Apr;60(2):227-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases].
  • Local transanal excision as primary treatment of rectal and anal canal adenomas in selected patients is supported by the recent literature.
  • Sixteen patients with low rectal or anal canal neoplastic polyps underwent transanal resection.
  • [MeSH-major] Intestinal Polyps / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Digestive System Surgical Procedures / methods. Humans. Middle Aged

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  • (PMID = 18689170.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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3. Ciriza de Los Ríos C, Tomás Moro E, García Durán F, Alvarez Sánchez J, Bermejo San José F, Valer López-Fando P, Carneros Martín JA, Piqueras Alcol B, Rodríguez Agulló JL: [Inflammatory cloacogenic polyps: a rare cause of rectal bleeding]. Gastroenterol Hepatol; 2007 Oct;30(8):461-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory cloacogenic polyps: a rare cause of rectal bleeding].
  • Inflammatory cloacogenic polyps are infrequent lesions that usually arise in the anorectal zone.
  • Two cases of rectal bleeding related to cloacogenic polyps with different endoscopic appearance are reported.
  • Endoscopists should be familiar with this entity, which should be considered in the differential diagnosis with other polypoid lesions observed in colonoscopy.
  • [MeSH-major] Intestinal Polyps / diagnosis. Rectal Diseases / diagnosis
  • [MeSH-minor] Adult. Anal Canal. Colonoscopy. Diagnosis, Differential. Female. Gastrointestinal Hemorrhage / etiology. Humans

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  • (PMID = 17949613.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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4. Solaz Moreno E, Vallalta Morales M, Silla Búrdalo G, Cervera Miguel JI, Díaz Beveridge R, Rayón Martín JM: [Primary melanoma of the rectum: an infrequent neoplasia with an atypical presentation]. Clin Transl Oncol; 2005 May;7(4):171-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The main clinical presentations are local symptoms such as rectal bleeding, anal mass or pain, or a change in bowel habits.
  • The tumour is frequently mistaken for benign conditions as haemorrhoids or rectal polyps.
  • [MeSH-major] Melanoma / diagnosis. Rectal Neoplasms / diagnosis

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  • (PMID = 15960927.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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5. Smith FB, Aksenov S: Potential role of nuclear appearance in pathologic recognition and delimitation of sessile serrated polyps of the colon: a karyometric study. Anal Quant Cytol Histol; 2007 Oct;29(5):326-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Potential role of nuclear appearance in pathologic recognition and delimitation of sessile serrated polyps of the colon: a karyometric study.
  • STUDY DESIGN: Digitized images of nuclei of superficial crypt cells from SSPs, banal hyperplastic polyps (BHPs), tubular adenomas (TAs) and normal colonic mucosa (N) in surgical pathology specimens were analyzed for size, shape, area, optical density (summed and average) and 22 Markovian texture characteristics.

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  • (PMID = 17987813.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Kilic N, Ucan ON, Osman O: Colonic polyp detection in CT colonography with fuzzy rule based 3D template matching. J Med Syst; 2009 Feb;33(1):9-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Colonic polyp detection in CT colonography with fuzzy rule based 3D template matching.
  • In this paper, we introduced a computer aided detection (CAD) system to facilitate colonic polyp detection in computer tomography (CT) data using cellular neural network, genetic algorithm and three dimensional (3D) template matching with fuzzy rule based tresholding.
  • Then, the system performs a 3D template matching within four layers with three different cell of 8 x 8, 12 x 12 and 20 x 20 to detect polyps.
  • The CAD system is evaluated with 1043 CT colonography images from 16 patients containing 15 marked polyps.
  • [MeSH-major] Colonic Polyps / diagnostic imaging. Colonography, Computed Tomographic / methods. Fuzzy Logic. Neural Networks (Computer). Radiographic Image Interpretation, Computer-Assisted / methods

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  • (PMID = 19238892.001).
  • [ISSN] 0148-5598
  • [Journal-full-title] Journal of medical systems
  • [ISO-abbreviation] J Med Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. O'Brien DP 4th: Polyps in the ileal pouch. Clin Colon Rectal Surg; 2008 Nov;21(4):300-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polyps in the ileal pouch.
  • Total proctocolectomy and ileal pouch-anal anastomosis is the operation of choice for patients with familial adenomatous polyposis.
  • With this operation comes the risk of developing ileal pouch polyps.
  • Endoscopic polypectomy of medium and large polyps should be performed.
  • Sulindac is effective in the reduction and often in the elimination of numerous smaller pouch polyps.
  • Future studies are necessary to determine the role of sulindac and other chemotherapeutic agents in preventing the development of these polyps.

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  • (PMID = 20011442.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780248
  • [Keywords] NOTNLM ; Polyps / familial adenomatous polyposis / ileal pouch
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8. Ewertsen C, Svendsen CB, Svendsen LB, Mogensen AM: [Inflammatory cloacogenic polyp]. Ugeskr Laeger; 2008 Aug 25;170(35):2708
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Inflammatory cloacogenic polyp].
  • [Transliterated title] Inflammatorisk kloakogen polyp.
  • We present a case of inflammatory cloacogenic polyp in a 28-year-old man who had suffered from intermittent rectal bleeding for four years.
  • A colonoscopy showed anal polyps.
  • The patient had no previous medical history and had no known family history of polyps.
  • Histopathology showed changes in the colonic mucous membrane consistent with the diagnosis inflammatory cloacogenic polyp, no dysplasia.
  • [MeSH-major] Anus Neoplasms / pathology. Intestinal Polyps / pathology
  • [MeSH-minor] Adult. Colonoscopy. Diagnosis, Differential. Gastrointestinal Hemorrhage / diagnosis. Humans. Intestinal Mucosa / pathology. Male. Rectal Diseases / diagnosis

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  • (PMID = 18761864.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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9. Cordero Fernández C, Pizarro Moreno A, Garzón Benavides M, García-Lozano R, Belda Laguna O, Sobrino S, Bozada JM, Zulueta Dorado T: [Follow-up after surgical treatment of patients with familial adenomatous polyposis: results in a southern Spanish population]. Rev Esp Enferm Dig; 2007 Aug;99(8):440-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The study was to assess changes in the rectal mucosa and pouch in a series of patients with familial adenomatous polyposis (FAP) who underwent either subtotal colectomy and ileorectal anastomosis (IRA) or proctocolectomy and ileal pouch-anal anastomosis (IPAA), and to evaluate the suitability of the follow-up interval and postoperative treatment employed to prevent the development of cancer.
  • The number and both macroscopic and histological features of polyps before and after surgery, the treatment, and complications were all analyzed.
  • [MeSH-minor] Adolescent. Adult. Anal Canal / surgery. Anastomosis, Surgical. Digestive System Surgical Procedures / methods. Female. Follow-Up Studies. Humans. Male. Middle Aged. Spain

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  • (PMID = 18020859.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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10. Gupta PJ: A study of the symptomatology of hypertrophied anal papillae and fibrous anal polyps. Bratisl Lek Listy; 2005;106(1):30-3
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  • [Title] A study of the symptomatology of hypertrophied anal papillae and fibrous anal polyps.
  • BACKGROUND: The presence of Hypertrophied anal papillae and fibrous anal polyps are often ignored in proctology practice.
  • PATIENTS AND METHODS: The study was carried out in 136 patients with chronic anal fissure having concomitant hypertrophied anal papillae or fibrous anal polyps.
  • After relieving sphincter spasm by sphincterotomy, the polyps or papillae were destroyed using the radio frequency device.
  • A comparison was made for the associated complaints like pruritus, pricking sensation, wetness, crawling sensation in the anus etc. before and after the removal of papillae or polyps by an independent observer blinded to the procedure.
  • There was significant reduction in pruritus (p=0.0003), discharge per anus (p=0.0006), crawling sensation in the anus (p=0.0004) and that of incomplete evacuation (p=0.001) At the follow up after 18 months, only 9 % of patients had recurrence of either anal fissure or symptoms like pruritus.
  • CONCLUSION: This study establishes that removal of hypertrophied anal papillae and fibrous polyps should be carried on a routine basis during surgical treatment of anal fissure.
  • [MeSH-major] Anus Diseases / diagnosis. Intestinal Polyps / diagnosis

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  • (PMID = 15869011.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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11. Sundaram P, Zomorodian A, Beaulieu C, Napel S: Colon polyp detection using smoothed shape operators: preliminary results. Med Image Anal; 2008 Apr;12(2):99-119
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  • [Title] Colon polyp detection using smoothed shape operators: preliminary results.
  • Computer-aided detection (CAD) algorithms identify locations in computed tomographic (CT) images of the colon that are most likely to contain polyps.
  • We evaluate our algorithm on patient data and provide free-response receiver-operating characteristic performance analysis over all size ranges of polyps.
  • A preliminary evaluation of our method on 35 patients yielded the following results (polyp diameter range; sensitivity; false positives/case): (10mm; 100%; 17.5), (5-10 mm; 89.7%, 21.23), (<5 mm; 59.1%; 23.9) and (overall; 80.3%; 23.9).

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  • (PMID = 17910934.001).
  • [ISSN] 1361-8423
  • [Journal-full-title] Medical image analysis
  • [ISO-abbreviation] Med Image Anal
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / U54 GM072970; United States / NCI NIH HHS / CA / R01 CA72023
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
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12. Pufulete M, Al-Ghnaniem R, Rennie JA, Appleby P, Harris N, Gout S, Emery PW, Sanders TA: Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. Br J Cancer; 2005 Mar 14;92(5):838-42
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  • A total of 68 subjects (33 men and 35 women, 36-78 years) free from colorectal polyps or cancer were recruited in a cross-sectional study.

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  • (PMID = 15726099.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0LVT1QZ0BA / Homocysteine; 9007-49-2 / DNA; 935E97BOY8 / Folic Acid; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2); EC 2.1.1.13 / 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; EC 4.2.1.22 / Cystathionine beta-Synthase
  • [Other-IDs] NLM/ PMC2361912
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13. Kadmon M: [Preventive surgery for familial adenomatous polyposis coli]. Chirurg; 2005 Dec;76(12):1125-34
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  • However, prophylactic colectomy after the manifestation of polyps but prior to the development of colorectal cancer is essential.
  • In case of the classic FAP phenotype, restorative proctocolectomy and ileal pouch-anal anastomosis is the procedure of choice.
  • The development of reliable guidelines for attenuated FAP variants requires further evidence from clinical studies on surgical strategy and the advantages of prophylactic surgery over regular endoscopic screening with removal of polyps.

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  • (PMID = 16323029.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 70
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14. You YN, Chua HK, Nelson H, Hassan I, Barnes SA, Harrington J: Segmental vs. extended colectomy: measurable differences in morbidity, function, and quality of life. Dis Colon Rectum; 2008 Jul;51(7):1036-43
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  • RESULTS: The most common indication for extended resections was multiple polyps, and for segmental resections, single malignancy.
  • [MeSH-minor] Adult. Aged. Anal Canal / surgery. Anastomosis, Surgical / methods. Colon, Sigmoid / surgery. Female. Follow-Up Studies. Humans. Ileum / surgery. Male. Middle Aged. Minnesota / epidemiology. Morbidity / trends. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 18470560.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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15. Bouasker I, Khalfallah M, El Ouaer MA, Smaali I, Hani MA, Dziri C: Giant inflammatory fibrous polyp of the anal verge. Tunis Med; 2010 Jun;88(6):449-50
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  • [Title] Giant inflammatory fibrous polyp of the anal verge.
  • [MeSH-major] Anus Neoplasms / pathology. Polyps / pathology

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  • (PMID = 20517861.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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16. Rifat Mannan AA, Kahvic M, Bharadwaj S, Grover VK: Gastric heterotopia of the anus: report of two rare cases and review of the literature. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):240-1
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  • [Title] Gastric heterotopia of the anus: report of two rare cases and review of the literature.
  • We report two cases of gastric heterotopia in the anus - one, in a 55-year-old man; and the other, in a 35-year-old woman.
  • Sigmoidoscopy showed presence of a single sessile anal polyp in the first patient and hemorrhoid in the other.
  • [MeSH-major] Anus Diseases / pathology. Choristoma / pathology. Gastric Mucosa

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  • (PMID = 18603693.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 9
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17. Wi JY, Kim SH, Lee JY, Kim SG, Han JK, Choi BI: Electronic cleansing for CT colonography: does it help CAD software performance in a high-risk population for colorectal cancer? Eur Radiol; 2010 Aug;20(8):1905-16
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  • Per-polyp sensitivity was calculated.
  • RESULTS: Eighty-six polyps were detected in 29 patients.
  • Per-polyp sensitivities of CAD with EC (93.8% and 100%) were higher than those without EC (84.4% and 87.5%) for polyps >or=6 mm and >or=10 mm, respectively.
  • CONCLUSION: Electronic cleansing has the potential to improve per-polyp sensitivity of CTC CAD, although the significantly larger number of FPs with EC remains to be improved.


18. Wang S, Yao J, Summers RM: Improved classifier for computer-aided polyp detection in CT colonography by nonlinear dimensionality reduction. Med Phys; 2008 Apr;35(4):1377-86
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  • [Title] Improved classifier for computer-aided polyp detection in CT colonography by nonlinear dimensionality reduction.
  • Computer-aided detection (CAD) has been shown to be feasible for polyp detection on computed tomography (CT) scans.
  • After initial detection, the dataset of colonic polyp candidates has large-scale and high dimensional characteristics.
  • We applied the proposed DMLLE method to a colonic polyp dataset of 175 269 polyp candidates with 155 features.
  • Visual inspection shows that true polyps with similar shapes are mapped to close vicinity in the low dimensional space.
  • For 6-9 mm polyps (193 true polyps contained in test set), when the number of false positives per patient is 9, SVM with DMLLE improves the average sensitivity from 70% to 83% compared with that of an SVM committee classifier which is a state-of-the-art method for colonic polyp detection (p<0.001).
  • [MeSH-major] Algorithms. Artificial Intelligence. Colonic Polyps / diagnostic imaging. Colonography, Computed Tomographic / methods. Pattern Recognition, Automated / methods. Radiographic Image Interpretation, Computer-Assisted / methods

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  • (PMID = 18491532.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CL999999
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS101228; NLM/ PMC2669284
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19. Galanis I, Dragoumis D, Tsolakis M, Zarampoukas K, Zarampoukas T, Atmatzidis K: Obstructive ileus due to a giant fibroepithelial polyp of the anus. World J Gastroenterol; 2009 Aug 7;15(29):3687-90
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  • [Title] Obstructive ileus due to a giant fibroepithelial polyp of the anus.
  • Fibroepithelial polyps or hypertrophied anal papillae are essentially skin tags that project up from the dentate line and the junction between the skin and the epithelial lining of the anus.
  • An extremely rare case of a giant hypertrophied anal papilla complicated by obstructive ileus is reported.
  • Fibroepithelial anal polyp, despite its size, should be included in the differential diagnosis of a smooth mass located near the anal verge, especially in a patient with a history of chronic anal irritation or infection.
  • [MeSH-major] Anus Neoplasms / complications. Ileus / etiology. Intestinal Polyps / complications. Neoplasms, Fibroepithelial / complications
  • [MeSH-minor] Aged. Anal Canal / pathology. Female. Humans

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  • (PMID = 19653351.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2721247
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20. Lorenz C, Nimmesgern T, Back M, Langwieler TE: Transanal single port microsurgery (TSPM) as a modified technique of transanal endoscopic microsurgery (TEM). Surg Innov; 2010 Jun;17(2):160-3
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  • The transanal placement of the SILS port was easy to perform; a prior dilatation of the anal sphincter was not necessary.
  • There were no perioperative or postoperative complications as verified by postoperative observation, rectoscopy, and anal ultrasound.
  • By using this new multichannel device TEM surgery was changed in a modified way while preserving the anal sphincter.
  • [MeSH-major] Anal Canal / surgery. Intestinal Polyps / surgery. Minimally Invasive Surgical Procedures / instrumentation. Proctoscopy / methods. Rectal Neoplasms / surgery

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  • (PMID = 20504794.001).
  • [ISSN] 1553-3514
  • [Journal-full-title] Surgical innovation
  • [ISO-abbreviation] Surg Innov
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Calva-Rodríguez R, González-Palafox MA, Rivera-Domínguez ME, García-Salazar JM, Calva-Cerqueira Bc D: [Inflammatory cloacogenic polyp]. Rev Gastroenterol Mex; 2007 Oct-Dec;72(4):371-5
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  • [Title] [Inflammatory cloacogenic polyp].
  • INTRODUCTION: Cloacogenic Polyps are characterized by the presence of inflammatory lesions in the lower rectum, and the anal transition zone.
  • The polyps can prolaps; this is due to the malfunction of the internal anal sphincter; and the smooth muscle that covers the rectum.
  • 85% lesions are located above the anal border and predominantly in the anterior lateral wall.
  • The polyps vary in size from 3-4 cm in diameter, and have a sessile appearance.
  • CONCLUSIONS: This entity of colon polyps is somewhat rare, and is seen in young adults; however its presence in infancy requires that we think of this entity when we formulate our differential diagnosis.
  • [MeSH-major] Intestinal Polyps / diagnosis. Rectal Diseases / diagnosis

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  • (PMID = 18595326.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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22. Tonus C, Neupert G, Glaser HJ, Stienecker K: [Double balloon enteroscopy. First surgical experience]. Chirurg; 2008 May;79(5):474-80
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  • The approach was oral in 75 cases and anal in 31.
  • RESULTS: Complete small intestine inspection could be performed completely orally in seven of 106 examinations; and in most cases a combined oral/anal approach was required.
  • These included 11 patients with angiodysplasias (14.7%) successfully treated with argon plasma coagulation (APC) and seven patients with small intestinal polyps (9.3%) that could be removed endoscopically.
  • [MeSH-major] Endoscopes, Gastrointestinal. Gastrointestinal Diseases / diagnosis. Gastrointestinal Hemorrhage / etiology. Gastrointestinal Neoplasms / diagnosis. Intestinal Obstruction / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Equipment Design. Female. Humans. Male. Middle Aged. Recurrence. Retrospective Studies

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  • (PMID = 18209985.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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23. Caruso M, Moore J, Goodall GJ, Thomas M, Phillis S, Tyskin A, Cheetham G, Lerda N, Takahashi H, Ruszkiewicz A: Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis. Virchows Arch; 2009 Mar;454(3):291-302
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  • Gene expression analysis demonstrated molecular differences between polyp types.
  • Further studies using quantitative real-time polymerase chain reaction on cathepsin E (CTSE) demonstrated a significantly (p < 0.05) higher expression in sessile serrated adenomas as compared to hyperplastic polyp and tubular adenomas.
  • Trefoil Factor 1 showed the same trend of expression for sessile serrated adenomas as compared to hyperplastic polyps and was significantly higher in both polyps compared to tubular adenomas.
  • Immunohistochemistry for both proteins demonstrated strong cytoplasmic staining of abnormal crypts in all sessile serrated adenomas, while staining in tubular adenomas and hyperplastic polyps was absent or weak and focal.
  • BRAF and KRAS mutation analysis were employed to further validate polyp discrimination.
  • This study demonstrates the over-expression in CTSE, in particular, and TFF1 in sessile serrated adenomas compared to both hyperplastic polyps and tubular adenomas.
  • [MeSH-minor] Aged. Female. Gene Expression. Humans. Immunohistochemistry. Intestinal Polyps / genetics. Intestinal Polyps / metabolism. Intestinal Polyps / pathology. Male. Mutation. Oligonucleotide Array Sequence Analysis. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. Proto-Oncogene Proteins p21(ras). Reverse Transcriptase Polymerase Chain Reaction. Trefoil Factor-1. Up-Regulation. ras Proteins / genetics

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  • (PMID = 19172291.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; 0 / TFF1 protein, human; 0 / Trefoil Factor-1; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.4.23.34 / Cathepsin E; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); EC 3.6.5.2 / ras Proteins
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24. Belshaw NJ, Elliott GO, Foxall RJ, Dainty JR, Pal N, Coupe A, Garg D, Bradburn DM, Mathers JC, Johnson IT: Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. Br J Cancer; 2008 Jul 8;99(1):136-42
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  • Quantitative methylation-specific PCR profiling applied to biopsies was used to quantify low levels of CGI methylation of 18 genes in the morphologically normal colonic mucosa of neoplasia-free subjects, adenomatous polyp patients, cancer patients and their tumours.
  • Multinomial logistic regression models based on the CGI methylation profiles from normal mucosa correctly identified 78.9% of cancer patients and 87.9% of non-cancer (neoplasia-free+polyp) patients (P=4.93 x 10(-7)) using APC, HPP1, p16, SFRP4, WIF1 and ESR1 methylation as the most informative variables.
  • Similarly, CGI methylation of SFRP4, SFRP5 and WIF1 correctly identified 61.5% of polyp patients and 78.9% of neoplasia-free subjects (P=0.0167).

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  • (PMID = 18542073.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2453007
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25. Chatelain D, Mokrani N, Fléjou JF: [Anal and anal margin tumors]. Ann Pathol; 2007 Dec;27(6):459-75
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  • [Title] [Anal and anal margin tumors].
  • [Transliterated title] Pathologie tumorale anale et péri-anale.
  • Tumors of the anal canal and anal margin are rare.
  • Benign tumors mainly consist of condylomas, cloacogenic polyps and fibro-epithelial polyps.
  • [MeSH-major] Anus Neoplasms / pathology

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  • (PMID = 18554556.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 110
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26. Leal RF, Ayrizono Mde L, Milanski M, Fagundes JJ, Moraes JC, Meirelles LR, Velloso LA, Coy CS: Detection of epithelial apoptosis in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. J Transl Med; 2010;8:11
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  • BACKGROUND: Ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice for patients with refractory ulcerative colitis (UC) and for familial adenomatous polyposis (FAP) with many rectal polyps.

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  • (PMID = 20113505.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / APAF1 protein, human; 0 / Apoptosis Regulatory Proteins; 0 / Apoptotic Protease-Activating Factor 1; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspase 9
  • [Other-IDs] NLM/ PMC2843649
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27. Ranger-Moore J, Frank D, Lance P, Alberts D, Yozwiak M, Bartels HG, Einspahr J, Bartels PH: Karyometry in rectal mucosa of patients with previous colorectal adenomas. Anal Quant Cytol Histol; 2005 Jun;27(3):134-42
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  • OBJECTIVE: To determine whether karyometric measurements taken in biopsies from histologically normal-appearing rectal mucosa could serve as a biomarker for the risk of recurrence of polyps.
  • MATERIALS AND METHODS: Biopsies were taken from the rectal mucosa of cases with a prior history of colonic polyps at the baseline of the study.
  • In 57 cases recurrent polyps occurred (R cases); in 72 cases no recurrent disease was found at the end of the study (NR cases).
  • All cases with a prior history of colonic polyps showed a nuclear abnormality deviating from normal.
  • CONCLUSION: Measurement of a sample of 100 nuclei from the rectal mucosa will suggest, for approximately 10% of cases, that a high risk for recurrence of adenomatous polyps exists and, for a slightly lower proportion, confirm that the nuclei deviate only slightly from those from individuals with no history of colonic polyps.

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  • (PMID = 16121634.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA-41108; United States / NCI NIH HHS / CA / CA-53877-09
  • [Publication-type] Clinical Trial; Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cholagogues and Choleretics; 724L30Y2QR / Ursodeoxycholic Acid
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28. Karuppiah SV, Dhaliwal A, Loudon MA: Retrieval of large colonic polyps: simple use of proctoscope. J Laparoendosc Adv Surg Tech A; 2007 Dec;17(6):799-801
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  • [Title] Retrieval of large colonic polyps: simple use of proctoscope.
  • Retrieval of polyps during colonoscopic procedures can be technically difficult and time consuming.
  • This is particularly the case when attempting to retrieve large polyps intact through the anal canal of an anxious patient with a hypertonic sphincter.
  • In this paper, we describe a simple technique that permits the complete removal of a large polyp intact by using a readily available theater instrument.
  • [MeSH-major] Colonic Polyps / surgery. Proctoscopes

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  • (PMID = 18158813.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Shin A, Shrubsole MJ, Rice JM, Cai Q, Doll MA, Long J, Smalley WE, Shyr Y, Sinha R, Ness RM, Hein DW, Zheng W: Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk. Cancer Epidemiol Biomarkers Prev; 2008 Feb;17(2):320-9
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  • [Title] Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.
  • Most colorectal cancers arise from adenomatous polyps or certain hyperplastic polyps.
  • Only a few studies have investigated potential genetic modifiers of the associations between meat intake and polyp risk, and results are inconsistent.
  • Using data from the Tennessee Colorectal Polyp Study, a large colonoscopy-based study, including 1,002 polyp cases (557 adenoma only, 250 hyperplastic polyp only, 195 both polyps) and 1,493 polyp-free patients, we evaluated the association of colorectal polyp risk with carcinogen exposure from meat and genetic polymorphisms in enzymes involved in heterocyclic amine (HCA) metabolism, including N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2), cytochrome P450 1A2 (CYP1A2), and aryl hydrocarbon receptor (AhR).
  • No clear association was found for any polymorphisms with polyp risk.
  • However, apparent interactions were found for intake of meat and HCAs with AhR, NAT1, and NAT2 genotypes, and the interactions were statistically significant for the group with both adenomatous and hyperplastic polyps.
  • These results provide strong evidence for a modifying effect of metabolizing genes on the association of meat intake and HCA exposure with colorectal polyp risk.

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  • (PMID = 18268115.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA950103; United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / CA095103-010005; United States / NCI NIH HHS / CA / R01 CA097386-01; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / R01 CA034627; United States / NCI NIH HHS / CA / CA097386-01; United States / NCI NIH HHS / CA / R01 CA34627; United States / NCI NIH HHS / CA / R01 CA034627-15; United States / NCI NIH HHS / CA / P50 CA095103-010005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Aryl Hydrocarbon; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 2.3.1.- / Acetyltransferases
  • [Other-IDs] NLM/ NIHMS72769; NLM/ PMC2572782
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30. El-Khayat HA, El-Hodhod MA, Abd El-Basset FZ, Tomoum HY, El-Safory HA, Hamdy AM: Rectal bleeding in Egyptian children. Ann Trop Paediatr; 2006 Dec;26(4):337-44
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  • Others included colorectal polyps (21.1%), chronic colitis (16%) including inflammatory bowel diseases (5.2%), allergic colitis (2.6%), solitary rectal ulcer syndrome (1.5%) and non-specific colitis (6.7%).
  • Intussusception and Meckel's diverticulae were the cause in 7.3% and 2.6%, respectively, while other aetiologies included vascular (6.2%), systemic (3.6%), local anal (3.1%) and upper gastro-intestinal causes (1.5%).
  • CONCLUSION: In Egyptian children, infectious enterocolitis followed by colorectal polyps and chronic colitis are major causes of BPR.
  • [MeSH-minor] Acute Disease. Adolescent. Age Factors. Bacterial Infections / complications. Bacterial Infections / diagnosis. Child. Child, Preschool. Chronic Disease. Colitis / complications. Colitis / diagnosis. Diagnostic Techniques, Digestive System. Diarrhea / complications. Enterocolitis / complications. Enterocolitis / diagnosis. Female. Humans. Infant. Intestinal Diseases, Parasitic / complications. Intestinal Diseases, Parasitic / diagnosis. Intestinal Polyps / complications. Intestinal Polyps / diagnosis. Male. Prospective Studies. Rectum

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  • (PMID = 17132299.001).
  • [ISSN] 0272-4936
  • [Journal-full-title] Annals of tropical paediatrics
  • [ISO-abbreviation] Ann Trop Paediatr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Yeruham I, Perl S, Lahav D: Anal adenomatous polyps in a crossbred beef cow. Vet Rec; 2005 Aug 13;157(7):204
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  • [Title] Anal adenomatous polyps in a crossbred beef cow.
  • [MeSH-major] Adenomatous Polyps / veterinary. Anus Neoplasms / veterinary. Cattle Diseases / pathology

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  • (PMID = 16100372.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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32. Fridley BL, Serie D, Jenkins G, White K, Bamlet W, Potter JD, Goode EL: Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies. Genet Epidemiol; 2010 Jul;34(5):418-26
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  • We illustrate the use of this method through a genome-wide linkage study of colorectal cancer, and a genome-wide association study of colorectal polyps.

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
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  • (PMID = 20583285.001).
  • [ISSN] 1098-2272
  • [Journal-full-title] Genetic epidemiology
  • [ISO-abbreviation] Genet. Epidemiol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA104667-05; United States / NCI NIH HHS / CA / CA074794-12; United States / NCI NIH HHS / CA / R21 CA140879; United States / NCI NIH HHS / CA / U01 CA074799; United States / NCI NIH HHS / CA / RFA CA-95-011; United States / NCI NIH HHS / CA / CA074799-09S2; United States / NCI NIH HHS / CA / U01 CA074800-09; United States / NCI NIH HHS / CA / U24 CA074783; United States / NCI NIH HHS / CA / CA074794-09; United States / NCI NIH HHS / CA / CA074783-11; United States / NCI NIH HHS / CA / R01 CA104667; United States / NCI NIH HHS / CA / CA074800-11S1; United States / NCI NIH HHS / CA / U24 CA074794; United States / NCI NIH HHS / CA / CA078296-05S4; United States / NCI NIH HHS / CA / U24 CA074806; United States / NCI NIH HHS / CA / U01 CA074794-09; United States / NCI NIH HHS / CA / U24 CA097735; United States / NCI NIH HHS / CA / U01 CA074794; United States / NCI NIH HHS / CA / U01 CA074783-09S2; United States / NCI NIH HHS / CA / CA074800-09; United States / NCI NIH HHS / CA / U24 CA074806-11; United States / NCI NIH HHS / CA / U01 CA097735-05S1; United States / NCI NIH HHS / CA / U24 CA074783-11; United States / NCI NIH HHS / CA / U01 CA074799-09S2; United States / NCI NIH HHS / CA / RFA-CA-08-502; United States / NCI NIH HHS / CA / U01 CA097735; United States / NCI NIH HHS / CA / CA104667-05; United States / NCI NIH HHS / CA / U24 CA074800-11S1; United States / NCI NIH HHS / CA / U01 CA074783; United States / NCI NIH HHS / CA / U24 CA074799-11; United States / NCI NIH HHS / CA / U01 CA078296-05S4; United States / NCI NIH HHS / CA / U24 CA074799; United States / NCI NIH HHS / CA / CA097735-05S1; United States / NCI NIH HHS / CA / U01 CA074806; United States / NCI NIH HHS / CA / U24 CA074800; United States / NCI NIH HHS / CA / CA074799-11; United States / NCI NIH HHS / CA / U01 CA078296; United States / NCI NIH HHS / CA / U01 CA074800; United States / NCI NIH HHS / CA / U24 CA074794-12; United States / NCI NIH HHS / CA / U24 CA097735-07; United States / NCI NIH HHS / CA / CA074806-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS219897; NLM/ PMC2910528
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33. Geisler DP, Condon ET, Remzi FH: Single incision laparoscopic total proctocolectomy with ileopouch anal anastomosis. Colorectal Dis; 2010 Sep;12(9):941-3
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  • [Title] Single incision laparoscopic total proctocolectomy with ileopouch anal anastomosis.
  • A colonoscopy had demonstrated nearly 1000 polyps in the colon with several 1-cm polyps in the rectum.
  • The pouch anal anastomosis was performed intracorporeally and a diverting loop ileostomy created through the SIL port site.

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  • (PMID = 19895601.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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34. Moore JS, Cataldo PA, Osler T, Hyman NH: Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses. Dis Colon Rectum; 2008 Jul;51(7):1026-30; discussion 1030-1
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  • [MeSH-major] Adenoma / surgery. Carcinoid Tumor / surgery. Carcinoma in Situ / surgery. Colonic Polyps / surgery. Colonoscopy / methods. Microsurgery / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Aged. Anal Canal. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local. Retrospective Studies. Treatment Outcome


35. Gupta PJ: Radiofrequency surgery--novel techniques in the treatment of ano-rectal disease. Acta Chir Iugosl; 2006;53(2):23-9
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  • OBJECTIVE: This paper discusses author's clinical experience with radiofrequency for various ano-rectal pathologies namely hemorrhoids, anal fistula, anal polyps, sinuses and anal papillae.
  • [MeSH-minor] Anus Diseases / surgery. Humans

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  • (PMID = 17139880.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia and Montenegro
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36. Strijbos SA, Hueting WE, Schipper ME, Oostvogel HJ, van Vroonhoven TJ, Gooszen HG, van Laarhoven CJ: The ileo neo rectal anastomosis (INRA) in patients with familial adenomatous polyposis: clinical results at two years. Colorectal Dis; 2005 Jul;7(4):354-9
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  • The aims of the present study were to evaluate the function of the neorectum, to assess the morbidity and complications of the operation and to determine the incidence of neorectal polyps.
  • The anal sphincter complex was assessed by manometry and ultrasound examination.
  • Endoscopic examination showed normal mucosa and no evidence of polyp formation in all patients.
  • At a minimum follow up period of two years, no growth of polyps in the neorectum occurred.


37. Hadar T, Shvero J, Yaniv E, Shvili I, Leabu M, Koren R: Human topoisomerase II-alpha is highly expressed in sinonasal-inverted papilloma, but not in inflammatory polyp. J Cell Mol Med; 2008 Sep-Oct;12(5A):1551-8
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  • [Title] Human topoisomerase II-alpha is highly expressed in sinonasal-inverted papilloma, but not in inflammatory polyp.
  • Our goal was to investigate by immunochemistry the expression level of topoII-in inverted papilloma, inflammatory nasal polyp and normal sinonasal epithelium and to compare it with expression level of Ki67.
  • In inflammatory nasal polyp group, topoII-alpha index was 2.4 +/- 2.1, and the difference in the topoII-alpha index between inverted papilloma and inflammatory polyp group was also statistically significant.
  • In the inflammatory nasal polyp group Ki67 index was 5.9 +/- 3.4.
  • The difference in th Ki67 index between inverted papilloma and inflammatory nasal polyp groups was statistically significant.
  • These results suggest that the inverte papilloma contains a significantly higher cell population with proliferative activity by comparison with normal sinonasal and inflammatory polyp epithelia, showing a significant correlation between topoII-alpha and Ki67 expression, and indicating that topoII-alpha could be a independent prognostic factor for a putative malignant transformation.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Epithelium / enzymology. Female. Humans. Inflammation / enzymology. Inflammation / pathology. Ki-67 Antigen / metabolism. Male. Middle Aged. Nasal Polyps / enzymology. Nasal Polyps / pathology

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  • (PMID = 18544048.001).
  • [ISSN] 1582-1838
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
  • [Other-IDs] NLM/ PMC3918071
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38. Näppi J, Yoshida H: Virtual tagging for laxative-free CT colonography: pilot evaluation. Med Phys; 2009 May;36(5):1830-8
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  • The effect of virtual tagging was evaluated by comparing the detection accuracy of a fully automated polyp detection scheme without and with the method.
  • [MeSH-major] Artifacts. Artificial Intelligence. Colonic Polyps / diagnostic imaging. Colonography, Computed Tomographic / methods. Pattern Recognition, Automated / methods. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods

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  • (PMID = 19544802.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA095279; United States / NCI NIH HHS / CA / R56 CA095279; United States / NCI NIH HHS / CA / CA095279
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Laxatives
  • [Other-IDs] NLM/ PMC2736708
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39. Wang S, Li L, Cohen H, Mankes S, Chen JJ, Liang Z: An EM approach to MAP solution of segmenting tissue mixture percentages with application to CT-based virtual colonoscopy. Med Phys; 2008 Dec;35(12):5787-98
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  • [MeSH-minor] Algorithms. Colonic Polyps / diagnosis. Colonic Polyps / pathology. Contrast Media / pharmacology. Early Detection of Cancer. Equipment Design. Humans. Intestines / pathology. Models, Statistical. Models, Theoretical

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  • (PMID = 19175136.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R33 CA120917-02; United States / NCI NIH HHS / CA / R01 CA082402-06; United States / NCI NIH HHS / CA / R01 CA082402; United States / NCI NIH HHS / CA / R01 CA082402-05; United States / NCI NIH HHS / CA / R01 CA082402-04A2; United States / NCI NIH HHS / CA / R21 CA120917; United States / NCI NIH HHS / CA / R01 CA082402-07; United States / NCI NIH HHS / CA / CA120917; United States / NCI NIH HHS / CA / R21 CA120917-01A1; United States / NCI NIH HHS / CA / CA082402; United States / NCI NIH HHS / CA / R33 CA120917
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ NIHMS74380; NLM/ PMC2633412
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40. Whittle DO, Lee MG, Hanchard B: Juvenile polyposis syndrome. West Indian Med J; 2010 Jun;59(3):306-8
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  • Juvenile polyposis syndrome (JPS) is rare and is present when there are multiple juvenile polyps in the gastrointestinal tract, usually the colon.
  • We report the case of a 21-year old male with a two-year history of intermittent rectal bleeding and anal protrusion.
  • Colonoscopy revealed multiple pedunculated cherry red polyps mainly in the left colon.
  • Histology confirmed juvenile polyps.
  • It is important to distinguish between patients with JPS and patients with an isolated harmatomatous juvenile polyp.

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  • (PMID = 21291112.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Jamaica
  • [Chemical-registry-number] Juvenile polyposis syndrome
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41. Maser EA, Present DH: Pouch-ouch. Curr Opin Gastroenterol; 2008 Jan;24(1):70-4
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  • PURPOSE OF REVIEW: For patients who require colectomy, the ileal pouch anal anastomosis operation has alleviated the need for permanent ileostomy and has improved associated self-esteem issues.
  • This review highlights the most recent research in the pathophysiology, risk factors, diagnosis and management of pouchitis, and pouch surveillance for neoplasia in patients who had ulcerative colitis.
  • Cancer in the residual rectal mucosa, in the ileal mucosa, and in pouch polyps occurs frequently enough to warrant surveillance.
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Humans. Monitoring, Physiologic. Postoperative Complications / diagnosis. Postoperative Complications / physiopathology. Postoperative Complications / therapy. Precancerous Conditions / pathology. Risk Factors

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  • (PMID = 18043236.001).
  • [ISSN] 1531-7056
  • [Journal-full-title] Current opinion in gastroenterology
  • [ISO-abbreviation] Curr. Opin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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42. Qiu HZ, Lin GL, Zhou JL, Xiao Y, Wu B: [Transanal endoscopic microsurgery for the treatment of localized rectal neoplasms]. Zhonghua Wai Ke Za Zhi; 2009 Jul 1;47(13):981-3
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  • The average distance of lesions from the anal verge was (7.6 +/- 2.8) cm (range, 5-20 cm).
  • The postoperative pathological examination identified 28 cases of rectal adenoma, 25 rectal adenocarcinoma or carcinomatous changes of adenoma (14 cases with phase Tis tumor, 5 cases T1 and 6 cases T2), 7 rectal carcinoid and 15 cases of inflammatory polyps or others.
  • Postoperative complications occurred in 4 cases (5.3%), included 2 cases of anal hemorrhage, 1 case of pulmonary infection and 1 urinary infection.
  • [MeSH-minor] Adult. Aged. Anal Canal / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures. Retrospective Studies. Treatment Outcome

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  • (PMID = 19957806.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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43. May A, Nachbar L, Ell C: Double-balloon enteroscopy (push-and-pull enteroscopy) of the small bowel: feasibility and diagnostic and therapeutic yield in patients with suspected small bowel disease. Gastrointest Endosc; 2005 Jul;62(1):62-70
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  • On average, 240 +/- 100 cm of the small bowel was visualized by using the oral route and 140 +/- 90 cm was visualized by using the anal route.
  • The main diagnosis was angiodysplasia (40/109; 37%); erosions and ulcerations of various etiologies were found in 27% (29/109).
  • Polyps and tumors were identified, including malignancy, in 25% (27/109).
  • Visualization and tissue sampling are possible in the entire small bowel by using the oral and anal approaches, and treatment is possible in the same way as in standard endoscopy, avoiding open surgery.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Equipment Design. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies

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  • [CommentIn] Gastrointest Endosc. 2005 Jul;62(1):71-5 [15990822.001]
  • (PMID = 15990821.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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44. Pérez-Cuadrado E, Más P, Hallal H, Shanabo J, Muñoz E, Ortega I, López Martín A, Torrella E, López Higueras A, Martín A, Carballo F: Double-balloon enteroscopy: a descriptive study of 50 explorations. Rev Esp Enferm Dig; 2006 Feb;98(2):73-81
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  • RESULTS: We carried out enteroscopy studies in 44 patients by the oral route and, in 6 additional patients, by both the oral and anal routes.
  • We reached the ileon with the oral route in all cases but one (jejunal stenosis), and in 4 cases out of 7 with the anal route, with an average duration of 73 minutes.
  • We treated 19 patients with angiodysplasia (1 to 20 synchronous lesions) with argon, and 4 patients with polyps using polipectomy (sporadic polyps or Peutz-Jeghers syndrome).
  • CONCLUSIONS: Double-balloon enteroscopy is a useful and effective technique in the diagnosis and treatment of small intestine diseases, thus complementing capsule endoscopy.
  • [MeSH-major] Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestine, Small / pathology

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  • [CommentIn] Rev Esp Enferm Dig. 2006 Feb;98(2):65-8, 69-72 [16566638.001]
  • (PMID = 16566639.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Capsules
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45. Filingeri V, Gravante G, Cassisa D: Clinical applications of radiofrequency in proctology: a review. Eur Rev Med Pharmacol Sci; 2006 Mar-Apr;10(2):79-85
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  • The authors describe the use of radiofrequencies in proctology by making a literature review for every major proctologic disease (hemorrhoids, anal fistulas, anal fissure, sinus pilonidalis, hypertrophied anal papillae).
  • In the treatment of anal fissures, radiofrequency subcutaneous lateral internal sphincterotomy has been described.
  • For anal fistulas, both radiofrequency fistulotomy and fistulectomy.
  • Finally, radiofrequency sinotomy for sinus pilonidalis and coagulation for hypertrophied anal papillae are present in literature.
  • [MeSH-minor] Fissure in Ano / surgery. Hemorrhoids / surgery. Humans. Polyps / surgery. Rectal Fistula / surgery

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  • (PMID = 16705953.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 72
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46. Linguraru MG, Zhao S, Van Uitert RL, Liu J, Fletcher JG, Manduca A, Summers RM: CAD of colon cancer on CT colonography cases without cathartic bowel preparation. Conf Proc IEEE Eng Med Biol Soc; 2008;2008:2996-9
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  • Computer-aided diagnosis (CAD) systems must show sufficient versatility to produce robust analysis on a large variety of data.
  • This procedure introduces additional challenges for the diagnosis, such as poorly tagged stool, stool sticking to colonic walls, and heterogeneous stool (tagged stool mixed with air or untagged stool).
  • Colonoscopy data are automatically cleansed of residual stool to enhance the polyp appearance for improved diagnosis.
  • Results show stool removal accuracy on polyps which are partially or fully covered by stool.
  • The automatic detection of colon polyps using our CAD system on cathartic-free data improves considerably with the addition of the automatic stool removal module from 74% to 86% true positive (TP) rate at 6.4 false positives (FP)/case.
  • [MeSH-major] Colon / diagnostic imaging. Colon / pathology. Colonography, Computed Tomographic / methods. Diagnosis, Computer-Assisted / methods. Pattern Recognition, Automated / methods

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  • (PMID = 19163336.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CL999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Laxatives
  • [Other-IDs] NLM/ NIHMS69939; NLM/ PMC2630581
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47. Zhu H, Liang Z, Pickhardt PJ, Barish MA, You J, Fan Y, Lu H, Posniak EJ, Richards RJ, Cohen HL: Increasing computer-aided detection specificity by projection features for CT colonography. Med Phys; 2010 Apr;37(4):1468-81
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  • This study aims to develop projection-based features which characterize true and false positives to increase the specificity while maintaining high sensitivity in detecting colonic polyps.
  • METHODS: In this study, two-dimensional projection images are obtained from each initial polyp candidate or volume of interest, and features are extracted from both the gray and color projection images to differentiate FPs from true positives.
  • These projection features were tested to exclude different types of FPs, such as haustral folds, rectal tubes, and residue stool using a database of 325 patient studies (from two different institutions), which includes 556 scans at supine and/or prone positions with 347 polyps and masses sized from 5 to 60 mm.
  • The experimental evaluation was conducted for large polyps (> or = 10 mm) and medium-sized polyps (5-9 mm) separately.
  • RESULTS: For large polyps, the additional usage of the projection features reduces the FP rate from 5.31 to 1.92 per scan at the comparable by-polyp sensitivity level of 93.1%.
  • For medium-sized polyps, the FP rate is reduced from 8.89 to 5.23 at the sensitivity level of 80.6%.
  • The percentages of FP reduction are 63.9% and 41.2% for the large and medium-sized polyps, respectively, without sacrificing detection sensitivity.
  • CAD of colonic polyps is supposed to help radiologists to improve their performance in interpreting computed tomographic colonography images.
  • [MeSH-major] Colonic Polyps / diagnostic imaging. Colonography, Computed Tomographic / methods. Diagnosis, Computer-Assisted / methods

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  • (PMID = 20443468.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA082402; United States / NCI NIH HHS / CA / R21 CA120917; United States / NCI NIH HHS / CA / CA120917; United States / NCI NIH HHS / CA / CA082402; United States / NCI NIH HHS / CA / R33 CA120917
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2848845
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48. Takayama O, Yamamoto H, Damdinsuren B, Sugita Y, Ngan CY, Xu X, Tsujino T, Takemasa I, Ikeda M, Sekimoto M, Matsuura N, Monden M: Expression of PPARdelta in multistage carcinogenesis of the colorectum: implications of malignant cancer morphology. Br J Cancer; 2006 Oct 9;95(7):889-95
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  • Immunohistochemical analysis indicated that PPARdelta expression increased from normal mucosa to adenomatous polyps to CRC.

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  • (PMID = 16969348.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / PPAR delta; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2360534
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49. Papadopoulos IN, Danias N, Zoumpouli CK: Fibroepithelial polyp in an anal fistulous track: a sign of chronic pathology. BMJ Case Rep; 2010;2010
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  • [Title] Fibroepithelial polyp in an anal fistulous track: a sign of chronic pathology.
  • Hypertrophied anal papillae and fibroepithelial polyps are benign acquired polypoid lesions of the anal canal.
  • The development and protrusion of a fibroepithelial polyp in an anal fistulous track is described.
  • This is a rare physical sign of chronic anal pathology.

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  • [ErratumIn] BMJ Case Rep. 2010;2010:doi/10.1136/bcr.08.2009.2169corr1. Zoumpouli, Christine K [added]
  • (PMID = 22242043.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027388
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50. Mönkemüller K, Weigt J, Treiber G, Kolfenbach S, Kahl S, Röcken C, Ebert M, Fry LC, Malfertheiner P: Diagnostic and therapeutic impact of double-balloon enteroscopy. Endoscopy; 2006 Jan;38(1):67-72
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  • RESULTS: Seventy DBE procedures were carried out in 53 patients (34 men, 19 women; mean age 60 years, range 24 - 80) by the oral route in 46 cases and the anal route in 24.
  • The indications for the examination were gastrointestinal bleeding (n = 29), suspected Crohn's disease (n = 6), abdominal pain (n = 4), polyp removal or evaluation in polyposis syndromes (n = 6), chronic diarrhea (n = 4), and surveillance or tumor search (n = 4).
  • A new diagnosis was obtained in 26 of the 53 patients (49 %).
  • The findings in the 70 procedures were angiodysplasia (n = 13), ulcerations or erosions (n = 5), jejunitis or ileitis (n = 5), tumors (n = 5), stenosis (n = 4), polyps (n = 5), lymphangiectasias (n = 4), Crohn's disease (n = 4), and normal (n = 17).
  • CONCLUSION: In almost two-thirds of the patients examined, DBE was clinically useful for obtaining a new diagnosis and starting new treatments, changing existing treatments, carrying out surgical intervention, or providing therapeutic endoscopy.
  • DBE is a useful and safe method of obtaining tissue for diagnosis, providing hemostasis, and carrying out polypectomy.
  • [MeSH-major] Crohn Disease / diagnosis. Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / diagnosis. Intestinal Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiodysplasia / diagnosis. Colonic Polyps / diagnosis. Female. Hemostasis, Surgical. Humans. Male. Middle Aged

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  • [CommentIn] Gastroenterology. 2006 Sep;131(3):969-71 [16952572.001]
  • (PMID = 16429357.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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51. Xi Z, Hui Q, Zhong L: Q-switched alexandrite laser treatment of oral labial lentigines in Chinese subjects with Peutz-Jeghers syndrome. Dermatol Surg; 2009 Jul;35(7):1084-8
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  • BACKGROUND: Peutz-Jeghers syndrome (PJS) is characterized by gastrointestinal hamartomatous polyps and visible mucocutaneous lentigines distributed in the oral and anal mucosa, hands, face, and nails.
  • Although there are many reports regarding successful treatment of intestinal polyps of PJS, there is little information regarding treatment of lentigines.

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  • (PMID = 19438690.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Gholam P, Autschbach F, Hartschuh W: Schistosomiasis in an HIV-positive patient presenting as an anal fissure and giant anal polyp. Arch Dermatol; 2008 Jul;144(7):950-2
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  • [Title] Schistosomiasis in an HIV-positive patient presenting as an anal fissure and giant anal polyp.
  • [MeSH-major] Anus Diseases / diagnosis. Fissure in Ano / diagnosis. HIV Infections. Schistosomiasis / diagnosis
  • [MeSH-minor] Adult. Animals. Anthelmintics / administration & dosage. Anthelmintics / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Polyps / diagnosis. Polyps / drug therapy. Polyps / pathology. Polyps / surgery. Praziquantel / administration & dosage. Praziquantel / therapeutic use. Schistosoma mansoni / isolation & purification. Viral Load


53. Bermano G, Pagmantidis V, Holloway N, Kadri S, Mowat NA, Shiel RS, Arthur JR, Mathers JC, Daly AK, Broom J, Hesketh JE: Evidence that a polymorphism within the 3'UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer. Genes Nutr; 2007 Nov;2(2):225-32
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  • In addition, a disease association study was carried out in cohorts of patients with either adenomatous polyps, colorectal adenocarcinomas and in healthy controls.
  • A higher proportion of individuals with CC genotype at the GPx4 T/C 718 SNP was present in the cancer group, but not in the polyp group, compared with the control group (P < 0.05).

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  • [Other-IDs] NLM/ PMC2474949
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54. Heslin MJ, Hawkins A, Boedefeld W, Arnoletti JP, Frolov A, Soong R, Urist MM, Bland KI: Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer. Ann Surg; 2005 Jun;241(6):941-6; discussion 946-7
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  • The mean size of the polyps and cancers were 3.0 +/- 0.4 and 5.0 +/- 0.1 cm, respectively.
  • Down-regulation of 15-LOX-1 is an early event in the adenoma to carcinoma sequence, and reversal with celecoxib may represent one mechanism for chemoprevention of polyps or treatment of carcinomas.

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  • (PMID = 15912043.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors; 0 / Eicosanoids; 0 / Linoleic Acids; 0 / Pyrazoles; 0 / Sulfonamides; 5204-88-6 / 13-hydroxy-9,11-octadecadienoic acid; EC 1.13.11.33 / Arachidonate 15-Lipoxygenase; JCX84Q7J1L / Celecoxib
  • [Other-IDs] NLM/ PMC1357173
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55. Schaus BJ, Fazio VW, Remzi FH, Bennett AE, Lashner BA, Shen B: Clinical features of ileal pouch polyps in patients with underlying ulcerative colitis. Dis Colon Rectum; 2007 Jun;50(6):832-8
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  • [Title] Clinical features of ileal pouch polyps in patients with underlying ulcerative colitis.
  • Clinical features, malignant potential, and management of pouch polyps have not been characterized.
  • METHODS: We identified 23 ulcerative colitis patients with large polyps (size> or =1 cm) of the ileal pouch from our 2,512-case ulcerative colitis pouch database.
  • RESULTS: Of the 23 patients, 95.7 percent (22 patients) had pouch endoscopy indicated for the evaluation of symptoms when polyps were detected, and 60.9 percent of patients had the polyps in the pouch, 26.1 percent in the anal transitional zone, and 21.7 percent in the afferent limb.
  • The mean size of pouch polyps was 1.9 cm +/- 1 cm.
  • On histology, 21 patients (91.3 percent) had inflammatory-type polyps, and 2 (8.7 percent) had dysplastic or malignant polyps.
  • CONCLUSIONS: The majority of patients with large ileal pouch polyps were symptomatic.
  • These polyps were typically detected on the background of pouchitis, cuffitis, or Crohn's disease.
  • Although the majority of polyps were inflammatory type, polyps in two patients were dysplastic or malignant.
  • [MeSH-major] Colitis, Ulcerative / surgery. Colonic Pouches. Ileal Neoplasms / pathology. Intestinal Polyps / pathology. Proctocolectomy, Restorative

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  • (PMID = 17309000.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R03 DK 067275
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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56. Jeon J, Meza R, Moolgavkar SH, Luebeck EG: Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach. Math Biosci; 2008 May;213(1):56-70
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  • We apply these expressions to simulate the natural history of colorectal cancer and to evaluate the effect of a screen for adenomatous polyps and concomitant intervention on cancer risk.

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  • (PMID = 18374369.001).
  • [ISSN] 0025-5564
  • [Journal-full-title] Mathematical biosciences
  • [ISO-abbreviation] Math Biosci
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA107028-04; United States / NCI NIH HHS / CA / R01 CA047658; United States / NCI NIH HHS / CA / R01 CA107028; United States / NCI NIH HHS / CA / R01 CA107028-04
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  • [Other-IDs] NLM/ NIHMS50592; NLM/ PMC2442130
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57. Sierra R, Bajka M, Székely G: Tumor growth models to generate pathologies for surgical training simulators. Med Image Anal; 2006 Jun;10(3):305-16
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  • Emphasis was placed on the modeling of growth processes leading to the generation of macroscopically realistic findings of the most common pathologies in hysteroscopy, namely polyps and myomas found in the uterine cavity.

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  • (PMID = 16520084.001).
  • [ISSN] 1361-8415
  • [Journal-full-title] Medical image analysis
  • [ISO-abbreviation] Med Image Anal
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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58. Näppi J, Yoshida H: Adaptive correction of the pseudo-enhancement of CT attenuation for fecal-tagging CT colonography. Med Image Anal; 2008 Aug;12(4):413-26
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  • The effect of ADC on ftCTC was assessed visually and quantitatively by comparison of the accuracy of computer-aided detection (CAD) without and with the use of the ADC method in two different types of clinical ftCTC databases: 20 laxative ftCTC cases with 24 polyps, and 23 reduced-preparation ftCTC cases with 28 polyps.
  • With ADC, the free-response receiver operating characteristic curves indicating CAD performance in polyp detection yielded normalized partial area-under-curve values of 0.91 and 0.80 for the two databases, respectively, with statistically significant improvement over conventional thresholding-based approaches (p<0.05).

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  • (PMID = 18313349.001).
  • [ISSN] 1361-8423
  • [Journal-full-title] Medical image analysis
  • [ISO-abbreviation] Med Image Anal
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA095279-06; United States / NCI NIH HHS / CA / R01 CA095279-06; United States / NCI NIH HHS / CA / R01 CA095279-05; United States / NCI NIH HHS / CA / CA095279-04; United States / NCI NIH HHS / CA / R56 CA095279; United States / NCI NIH HHS / CA / CA095279-05; United States / NCI NIH HHS / CA / R01 CA095279-04; United States / NCI NIH HHS / CA / R01 CA131718; United States / NCI NIH HHS / CA / CA095279; United States / NCI NIH HHS / CA / R01 CA095279
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS62173; NLM/ PMC2762861
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59. Nikpour S, Ali Asgari A: Colonoscopic evaluation of minimal rectal bleeding in average-risk patients for colorectal cancer. World J Gastroenterol; 2008 Nov 14;14(42):6536-40
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  • Neoplastic polyps, colorectal carcinoma, and IBD were defined as significant lesions.
  • Hemorrhoids (54.2%), anal fissures (14.2%) and ulcerative colitis (14.2%) were the most common lesions and colonoscopy was normal in 8.0%.
  • Significant lesions were found in 121 (30.1%) patients, including 26 patients (6.5%) with adenocarcinoma and 30 (7.5%) with adenomatous polyps.
  • Almost all patients with significant lesions had at least one lesion in the distal colon; an adenocarcinoma and an adenomatous polyp in the proximal colon were found in 2 patients with hemorrhoids.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Hemorrhage / etiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Colitis, Ulcerative / complications. Colitis, Ulcerative / diagnosis. Female. Fissure in Ano / complications. Fissure in Ano / diagnosis. Hemorrhoids / complications. Hemorrhoids / diagnosis. Humans. Male. Middle Aged. Patient Selection. Predictive Value of Tests. Prevalence. Prospective Studies. Rectum. Risk Assessment. Sigmoidoscopy. Young Adult


60. Barreto-Zuñiga R, Tellez-Avila FI, Chavez-Tapia NC, Ramirez-Luna MA, Sanchez-Cortes E, Valdovinos-Andraca F, Zepeda-Gomez S: Diagnostic yield, therapeutic impact, and complications of double-balloon enteroscopy in patients with small-bowel pathology. Surg Endosc; 2008 May;22(5):1223-6
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  • The mean duration of the procedure was 63 (range 20-194) mins and 80 (range 20-150) minutes for the oral and anal routes, respectively.
  • The mean depth of small-bowel insertion was 250 and 200 cm for the oral and anal routes, respectively.
  • Impact in diagnosis and/or treatment was obtained in 50 patients (73.5%).
  • The commonest findings in the 68 patients were angiodysplasia (n = 11), polyps (n = 8), nodular lymphoid hyperplasia (n = 5) and normal (n = 20).
  • CONCLUSION: DBE is a useful tool for the diagnosis and treatment of patients with small-bowel pathology in whom traditional methods have not been effective.
  • In almost two-thirds of patients DBE was clinically useful for diagnosis and treatment.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestinal Diseases / surgery. Intestine, Small / pathology. Intestine, Small / surgery

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  • (PMID = 17943366.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
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61. Aranganathan S, Panneer Selvam J, Nalini N: Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis. Invest New Drugs; 2009 Jun;27(3):203-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] 1,2-Dimethylhydrazine. Animals. Catalase / metabolism. Colonic Polyps / pathology. Dose-Response Relationship, Drug. Drug Screening Assays, Antitumor. Glutathione / metabolism. Glutathione Peroxidase / metabolism. Glutathione Reductase / metabolism. Glutathione Transferase / metabolism. Lipid Peroxidation / drug effects. Male. Microvilli / drug effects. Microvilli / pathology. Rats. Rats, Wistar. Superoxide Dismutase / metabolism. Survival Analysis. Thiobarbituric Acid Reactive Substances / metabolism

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  • (PMID = 18648748.001).
  • [ISSN] 1573-0646
  • [Journal-full-title] Investigational new drugs
  • [ISO-abbreviation] Invest New Drugs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Thiobarbituric Acid Reactive Substances; E750O06Y6O / Hesperidin; EC 1.11.1.6 / Catalase; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase; EC 1.8.1.7 / Glutathione Reductase; EC 2.5.1.18 / Glutathione Transferase; GAN16C9B8O / Glutathione; IX068S9745 / 1,2-Dimethylhydrazine; Q9Q3D557F1 / hesperetin
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62. Danova NA, Robles-Emanuelli JC, Bjorling DE: Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs. Vet Surg; 2006 Jun;35(4):337-40
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  • [Title] Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs.
  • OBJECTIVE: To describe an anal approach for excision of primary rectal tumors in dogs and to report outcome.
  • METHODS: Review of medical records (1990-2000) of dogs with primary rectal neoplasia excised surgically using an anal approach with rectal prolapse.
  • RESULTS: Each dog had only 1 tumor type (adenocarcinoma [8], solitary polyp [5], carcinoma [4], plasmacytoma [2], adenoma [1], leiomyoma [1], mucinous carcinoma [1], and papilloma [1]).
  • CONCLUSION: Surgical excision of tumors of the caudal rectum can be accomplished through the anus after rectal prolapse.
  • CLINICAL RELEVANCE: An anal approach facilitated by rectal prolapse should be considered as a viable option for the surgical treatment of selected cases of tumors of the caudal aspect of the rectum in dogs.
  • [MeSH-major] Anal Canal / surgery. Dog Diseases / surgery. Rectal Neoplasms / veterinary
  • [MeSH-minor] Adenocarcinoma / surgery. Adenocarcinoma / veterinary. Animals. Disease-Free Survival. Dogs. Female. Male. Polyps / surgery. Polyps / veterinary. Postoperative Complications / veterinary. Records as Topic / veterinary. Retrospective Studies. Treatment Outcome. Wisconsin / epidemiology

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  • (PMID = 16756613.001).
  • [ISSN] 0161-3499
  • [Journal-full-title] Veterinary surgery : VS
  • [ISO-abbreviation] Vet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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63. Juhn E, Khachemoune A: Gardner syndrome: skin manifestations, differential diagnosis and management. Am J Clin Dermatol; 2010;11(2):117-22
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  • [Title] Gardner syndrome: skin manifestations, differential diagnosis and management.
  • Gardner syndrome is a variant of familial adenomatous polyposis (FAP) and results in the manifestation of numerous external and internal symptoms including gastrointestinal polyps, osteomas, tumors, and epidermoid cysts.
  • Fortunately, Gardner syndrome has characteristic polyps in the colon, osteomas, and also exhibits abnormalities in the retinal epithelium that discern it from others.
  • Surgery is the most effective method of management for Gardner syndrome; restorative proctocolectomy with ileal pouch anal anastomosis with mucosectomy is the top choice for colonic malignancies, and skin manifestations can be treated through a variety of excisions and therapy depending on location, size, and number of malignancies.
  • [MeSH-minor] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis. Colorectal Neoplasms, Hereditary Nonpolyposis / pathology. Colorectal Neoplasms, Hereditary Nonpolyposis / therapy. Diagnosis, Differential. Genetic Counseling / methods. Humans. Mutation

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  • (PMID = 20141232.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Number-of-references] 29
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64. Chalastras T, Athanassiadou P, Patsouris E, Eleftheriadou A, Kandiloros D, Papaxoinis K, Nicolopoulou-Stamati P: Differential rates of proliferation and apoptosis in nasal polyps correspond to alterations in DNA spatial distribution and nuclear polarization as observed by confocal microscopy. Eur Arch Otorhinolaryngol; 2010 Jul;267(7):1075-80
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  • [Title] Differential rates of proliferation and apoptosis in nasal polyps correspond to alterations in DNA spatial distribution and nuclear polarization as observed by confocal microscopy.
  • Imprint smears obtained from surgically removed nasal polyps of 20 patients were studied.
  • The polyps were classified according to their histological characteristics as: hyperplasia (simple and pronounced) and squamous metaplasia.
  • Positive immunoreaction for p53, Ki-67 and Bcl-2 was observed in 50, 65, and 50% of polyp's smears, respectively.
  • For each diagnosis, the rates were simple hyperplasia 60, 80 and 30%, pronounced hyperplasia 80, 100 and 40%, metaplasia 0, 0 and 100%, respectively.
  • [MeSH-major] Apoptosis / physiology. Carcinoma, Squamous Cell / pathology. DNA, Neoplasm / analysis. Ki-67 Antigen / analysis. Nasal Polyps / pathology. Precancerous Conditions / pathology. Proto-Oncogene Proteins c-bcl-2 / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 20039176.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 36015-30-2 / Propidium
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65. Ohmiya N, Taguchi A, Shirai K, Mabuchi N, Arakawa D, Kanazawa H, Ozeki M, Yamada M, Nakamura M, Itoh A, Hirooka Y, Niwa Y, Nagasaka T, Ito M, Ohashi S, Okamura S, Goto H: Endoscopic resection of Peutz-Jeghers polyps throughout the small intestine at double-balloon enteroscopy without laparotomy. Gastrointest Endosc; 2005 Jan;61(1):140-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of Peutz-Jeghers polyps throughout the small intestine at double-balloon enteroscopy without laparotomy.
  • This study evaluated the usefulness of this method for the resection of small-intestinal Peutz-Jeghers polyps.
  • METHODS: Two patients with Peutz-Jeghers syndrome underwent nonsurgical double-balloon enteroscopic resection of polyps throughout the small intestine.
  • OBSERVATIONS: Multiple polyps in the jejunum were successfully resected via the oral route, as were the polyps in the ileum via the anal route.
  • All 18 polyps (10-60 mm in size) were resected without subsequent bleeding or perforation.
  • Histopathologically, 3 large polyps (>30 mm diameter) were hamartomas with adenomatous components.
  • CONCLUSIONS: Double-balloon enteroscopy was safe and useful for the diagnosis and the treatment of Peutz-Jeghers polyps throughout the small intestine.
  • [MeSH-major] Catheterization. Endoscopy, Gastrointestinal / methods. Intestinal Polyps / etiology. Intestinal Polyps / therapy. Intestine, Small. Peutz-Jeghers Syndrome / complications

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  • (PMID = 15672077.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Ye H, Montgomery E, Epstein JI: Incidental anorectal pathologic findings in prostatic needle core biopsies: a 13-year experience from a genitourinary pathology consult service. Hum Pathol; 2010 Dec;41(12):1674-81
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  • (1) Neoplasia and polyps (n = 10).
  • Other neoplastic findings included 1 with low-grade B-cell lymphoma, 3 with hyperplastic polyps, 3 with tubular adenomas, and 1 with anal mucosa with high-grade dysplasia that was found to be a contaminant from another case. (2) Inflammatory changes (n = 20).
  • [MeSH-major] Anus Diseases / diagnosis. Incidental Findings. Prostatic Diseases / diagnosis
  • [MeSH-minor] Adenoma / pathology. Adenoma / surgery. Aged. Biopsy, Needle. Colonic Polyps / pathology. Humans. Intestinal Mucosa / pathology. Male. Middle Aged. Referral and Consultation

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20869745.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Albright JB, Bonatti H, Stauffer J, Dickson RC, Nguyen J, Harnois D, Jeanpierre C, Hinder R, Steers J, Chua H, Aranda-Michel J: Colorectal and anal neoplasms following liver transplantation. Colorectal Dis; 2010 Jul;12(7):657-66
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  • [Title] Colorectal and anal neoplasms following liver transplantation.
  • Data on neoplasms of the colon, rectum and anus in LT are limited.
  • METHOD: A retrospective evaluation of the incidence and clinical course of colorectal and anal malignancies and colonic polyps in a series of 467 consecutive LTs in 402 individuals between 1998 and 2001 was performed.
  • RESULTS: During a median follow up of 5.2 years, three colon adenocarcinomas, one EBV associated cecal posttransplant lymphoproliferative tumour and two HPV associated anal tumours were identified.
  • Pre-LT colonoscopy was performed in 161 patients (40%), and of 153 evaluable individuals, 53 (34.9%) had polyps.
  • Colonoscopy was performed in 186 patients (46.3%) median 14.8 (range 0.2-77.8) months post-LT and 55 (29.3%) had polyps.
  • Post-LT adenomatous polyps were detected in 47.3% of patients with pre-LT polyps vs 6.7% of patients without pre-LT polyps (P < 0.001).
  • No patient died from colorectal/anal malignancy.
  • CONCLUSION: The incidence of metachronous and new polyp formation in our study is similar to people who are not immunocompromised, but subgroups are at increased risk.
  • Viral-associated malignancies, including post-transplant lymphoproliferative disorders and anal cancer, are important entities in the LT population suggesting that complete screening of the colon, rectum and anus including pre-LT and post-LT colonoscopy should be utilized.
  • [MeSH-major] Anus Neoplasms / epidemiology. Colonic Neoplasms / epidemiology. Immunosuppression / adverse effects. Liver Transplantation

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  • (PMID = 19508543.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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68. Barreda B F, Combe G J, Valdez P LA, Sánchez L J: [Clinical aspects in polyps of the colon]. Rev Gastroenterol Peru; 2007 Apr-Jun;27(2):131-47
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  • [Title] [Clinical aspects in polyps of the colon].
  • INTRODUCTION: The colonics polyps according to their number, size, location, age of presentation and mainly, according to their histology, have the potentiality of malignant degeneration, which makes of a continuous study and pursuit susceptible.
  • OBJECTIVES: To evaluate the relation between the histologic type of the colon polyps, its location, the degree of dysplasia, the size, its possible commitment by carcinoma, the age, sex and the handling that has occurred them, in a series of 684 patients of the National Institute of Enfermedades Neoplásicas (INEN) between the 1 of January from 1974 to the 31 of March of the 2004.
  • MATERIAL AND METHODS: The revision of clinical histories of 840 patients with the diagnosis of colon polyp was made who attended the service of Gastroenterology of the INEN between the 1 of January from 1974 to the 31 of March of 2004 and a card predesigned for each clinical history filled.
  • 1162 resecteds polyps evaluated themselves in this period.
  • 156 patients by diagnosis related to cancer and familiar adenomatouspoliposis did not include themselves.
  • The final sample was of 684 patients, in whom it was 1057 polyps.
  • Other endoscopic findings were: internal hemorrhoids (172), colonic diverticulosis (50), anal fissure (4), and nonspecific ulcerative colitis (2).
  • RESULTS: 1057 polyps extirpated, by means of the endoscopy polipectomy were 1016, with colectomy were 32 and with transanal resection without colectomy they 9.
  • Within the histology of the 1057 polyps, 331 was briefed (31.3%) that were hyperplasic, 448 (42.4%) adenomas, 278 (26.3%) others and 35 (8.2%) adenocarcinomas on adenomas.
  • Adenocarcinoma (carcinomas on adenomas), was present mainly in polyps villous type, with dysplasia severe and greater to 10 mm.
  • Nevertheless, in smaller polyps of 5mm with dysplasia severe, was a polyp invaded by cancer, that represents the 0,8% of millimetric polyps.
  • The made handling was mainly endoscopic, with 96% of the resected polyps this way, also slogan transanal resection and segmental colonic resection.
  • The colectomy was necessary in 3% of all the made interventions, dysplasia severe or carcinoma was made in adenomatous polyps with, and in greater percentage in greater polyps of 20 mm (53%).
  • On the other hand, in polyps with level of invasion Haggitt 3 and 4, the colectomy was the election treatment.
  • CONCLUSIONS: The Evaluation of colonic polyps in INEN is predominantly by endoscopy.
  • The polyps are more frequent over the 50 years and have preferred location in the left colon.
  • All polyps, from the millimetric ones, including the hyperplasic, must be considered marks of neoplasia and extirpated in its totality.
  • [MeSH-major] Colonic Polyps / pathology. Colonic Polyps / surgery

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  • (PMID = 17712391.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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69. Gupta PJ: Feasibility of day care surgery in proctology. J Gastrointestin Liver Dis; 2006 Dec;15(4):359-62
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  • The procedures included hemorrhoidectomy, anal fistulotomy, sphincterotomy, and removal of rectal polyps, pilonidal sinotomy and anal stricturotomy.
  • However, an appropriate diagnosis of the disease, proper selection of the patients with respect to their suitability for surgery and a round-the-clock availability of patient communication with the nursing staff are a must for the successful outcome of the procedure.
  • [MeSH-major] Ambulatory Surgical Procedures. Anus Diseases / surgery. Digestive System Surgical Procedures. Rectal Diseases / surgery

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  • (PMID = 17205148.001).
  • [ISSN] 1842-1121
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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70. Chan NG, Penswick JL, Labelle E, Driman DK: Ectopic breast tissue presenting as an anal polyp. Can J Surg; 2007 Dec;50(6):E23-4
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  • [Title] Ectopic breast tissue presenting as an anal polyp.
  • [MeSH-major] Anus Diseases / pathology. Breast. Choristoma / pathology

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  • [Cites] BMJ. 1994 Sep 24;309(6957):797-800 [7950574.001]
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  • (PMID = 18067696.001).
  • [ISSN] 1488-2310
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2386226
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71. Pusiol T, Zorzi MG, Piscioli I: Coexistence of bladder prostatic-type polyp and urothelial papilloma. Anal Quant Cytol Histol; 2010 Oct;32(5):299-300
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  • [Title] Coexistence of bladder prostatic-type polyp and urothelial papilloma.

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  • (PMID = 22043507.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Letter
  • [Publication-country] United States
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72. Mittal R, Perakath B, Chase S, Jesudason MR, Nayak S: Transanal excision of anorectal lesions--a single centre experience. Trop Gastroenterol; 2010 Jan-Mar;31(1):65-8
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  • Tubulovillous adenomas and hyperplastic polyps were the commonest benign lesions.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Anal Canal / surgery. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Palliative Care. Postoperative Complications. Treatment Outcome

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  • (PMID = 20860237.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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73. Odofin O, Alexander R, Bowers H, Chave H, Branagan G: Do patients require outpatient follow-up after rapid referral double contrast barium enema? Colorectal Dis; 2009 Sep;11(7):729-32
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  • Hospital databases were cross-referenced to identify any patients presenting with a new diagnosis of colorectal malignancy between DCBE and April 2007.
  • Diagnoses: cancer 48 (9.2%), polyps 13 (2.5%), colitis 3 (0.6%), no significant pathology 457 (87.7%).
  • Reasons for multiple attendances were management of haemorrhoids/anal fissure or investigations of unrelated symptoms.

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  • (PMID = 18624822.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Barium Compounds
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74. Möschler O, May AD, Müller MK, Ell C, DBE-Studiengruppe Deutschland: [Complications in double-balloon-enteroscopy: results of the German DBE register]. Z Gastroenterol; 2008 Mar;46(3):266-70
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  • They reported 3894 DBE examinations (2685 using the oral route, 1209 using the anal route) with 1086 interventions.
  • [MeSH-major] Catheterization / statistics & numerical data. Endoscopy, Gastrointestinal / statistics & numerical data. Gastrointestinal Hemorrhage / epidemiology. Intestinal Perforation / epidemiology. Intestinal Polyps / epidemiology. Pancreatitis / epidemiology. Registries / statistics & numerical data


75. Felt-Bersma RJ, Cazemier M: Endosonography in anorectal disease: an overview. Scand J Gastroenterol Suppl; 2006;(243):165-74
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  • It was first used to evaluate rectal tumours and later also to investigate benign disorders of the anal sphincters and pelvic floor.
  • AE has been used for almost every possible disorder in the anal region and has increased our insight into anal pathology.
  • Studies comparing AE with endoanal magnetic resonance imaging (MRI) have shown that both methods are equally good for demonstrating defects in the external anal sphincter; the internal anal sphincter is better visualized with AE.
  • In low tubulovillous adenomas or malignant polyps considered removable locally, confirming the local resectability (T0 or T1) is mandatory.
  • 4. Anal carcinoma for staging.
  • In conclusion, AE images the internal and external anal sphincter with high accuracy.
  • It is easy to perform and is of particular value in the diagnosis of anal incontinence and perianal fistulae.
  • It is excellent in staging anal carcinoma and can also be used in staging rectal carcinoma, especially very low large malignant polyps.
  • [MeSH-major] Anus Diseases / ultrasonography. Endosonography. Rectal Diseases / ultrasonography

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  • (PMID = 16782637.001).
  • [ISSN] 0085-5928
  • [Journal-full-title] Scandinavian journal of gastroenterology. Supplement
  • [ISO-abbreviation] Scand. J. Gastroenterol. Suppl.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Number-of-references] 119
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76. Melis M, Gruel R, Darwin P, Drachenberg C, Shibata D: Full thickness transanal re-excision following endoscopic removal of malignant rectal polyps. Int J Colorectal Dis; 2009 May;24(5):531-6
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  • [Title] Full thickness transanal re-excision following endoscopic removal of malignant rectal polyps.
  • PURPOSE: Segmental resection is recommended for malignant polyps of the colon that are removed endoscopically with questionable margins.
  • We report our long-term results in patients treated by transanal re-excision (TAR) following endoscopic removal of malignant rectal polyps (MRP).
  • [MeSH-major] Anal Canal / surgery. Endoscopy. Rectal Neoplasms / surgery

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  • (PMID = 19159936.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
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77. Kita H, Yamamoto H, Yano T, Miyata T, Iwamoto M, Sunada K, Arashiro M, Hayashi Y, Ido K, Sugano K: Double balloon endoscopy in two hundred fifty cases for the diagnosis and treatment of small intestinal disorders. Inflammopharmacology; 2007 Apr;15(2):74-7
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  • [Title] Double balloon endoscopy in two hundred fifty cases for the diagnosis and treatment of small intestinal disorders.
  • Total enteroscopy was successfully achieved by the combination of both oral and anal approaches in 55 out of 71 cases in whom total enteroscopy was intended.
  • Of 250 patients, ulcerative and/or erosive lesions were found in 49 cases and tumors/polyps were found in 49 cases.
  • Double balloon enteroscopy is both feasible and useful technique for the diagnosis as well as treatment of small intestinal disorders.
  • [MeSH-major] Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestine, Small / pathology

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  • (PMID = 17450446.001).
  • [ISSN] 0925-4692
  • [Journal-full-title] Inflammopharmacology
  • [ISO-abbreviation] Inflammopharmacology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Switzerland
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78. Thomson M, Venkatesh K, Elmalik K, van der Veer W, Jaacobs M: Double balloon enteroscopy in children: diagnosis, treatment, and safety. World J Gastroenterol; 2010 Jan 7;16(1):56-62
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  • [Title] Double balloon enteroscopy in children: diagnosis, treatment, and safety.
  • METHODS: Fourteen patients (10 males) with a median age of 12.9 years (range 8.1-16.7) underwent DBE; 5 for Peutz-Jeghers syndrome (PJ syndrome), 2 for chronic abdominal pain, 4 for obscure gastrointestinal (GI) bleeding, 2 with angiomatous malformations (1 blue rubber bleb nevus syndrome) having persistent GI bleeding, and 1 with Cowden's syndrome with multiple polyps and previous intussusception.
  • Seven patients had both antegrade (trans-oral) and retrograde (trans-anal and via ileostomy) examinations.
  • Polyps were detected and successfully removed in all 5 patients with PJ syndrome, in a patient with tubulo-villous adenoma of the duodenum, in a patient with significant anemia and occult bleeding, and in a patient with Cowden's syndrome.
  • A diagnosis was made in a patient with multiple angiomata not amenable to endotherapy, and in 1 with a discrete angioma which was treated with argon plasma coagulation.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis. Intestinal Diseases / therapy. Intestine, Small / pathology

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  • (PMID = 20039449.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2799917
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79. Tulchinsky H, Keidar A, Strul H, Goldman G, Klausner JM, Rabau M: Extracolonic manifestations of familial adenomatous polyposis after proctocolectomy. Arch Surg; 2005 Feb;140(2):159-63; discussion 164
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  • INTERVENTIONS: Ileal pouch-anal anastomosis (n = 41), Kock pouch (n = 1), end ileostomy (n = 6).
  • CONCLUSIONS: Long-term morbidity and mortality were strongly related to the development of mesenteric tumors and ampullary-duodenal polyps.

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  • (PMID = 15723997.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pyrazoles; 0 / Sulfonamides; 094ZI81Y45 / Tamoxifen; JCX84Q7J1L / Celecoxib
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80. Wilson S, Wakelam MJ, Hobbs RF, Ryan AV, Dunn JA, Redman VD, Patrick F, Colbourne L, Martin A, Ismail T: Evaluation of the accuracy of serum MMP-9 as a test for colorectal cancer in a primary care population. BMC Cancer; 2006 Oct 31;6:258
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  • Respondents who describe any colorectal symptoms (except only abdominal bloating and/or anal symptoms) and are prepared to provide a blood sample for MMP9 estimation and undergo a colonoscopy (current gold standard investigation) will be recruited at GP based clinics by a research nurse.
  • The accuracy of MMP-9 will be assessed by comparing the MMP-9 level with the colonoscopy findings, and the combination of factors (e.g. symptoms and MMP-9 level) that best predict a diagnosis of malignancy (invasive disease or polyps) will be determined.
  • [MeSH-major] Colorectal Neoplasms / blood. Colorectal Neoplasms / diagnosis. Matrix Metalloproteinase 9 / blood

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  • (PMID = 17076885.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / A5103
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.35 / Matrix Metalloproteinase 9
  • [Other-IDs] NLM/ PMC1654179
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81. Gu GL, Wang SL, Wei XM, Bai L: Diagnosis and treatment of Gardner syndrome with gastric polyposis: a case report and review of the literature. World J Gastroenterol; 2008 Apr 7;14(13):2121-3
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  • [Title] Diagnosis and treatment of Gardner syndrome with gastric polyposis: a case report and review of the literature.
  • We present a case of a 23-year-old female patient with GS who presented with gastric polyposis and was successively treated with restorative proctocolectomy in combination with ileal pouch anal anastomosis (RPC/ IPAA), ileostomy, ileostomy closure operation, snare polypectomy during 8 mo.
  • [MeSH-major] Gardner Syndrome / diagnosis. Polyps / diagnosis. Stomach Diseases / diagnosis

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  • (PMID = 18395919.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Plant Extracts
  • [Other-IDs] NLM/ PMC2701539
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82. Cai W, Zalis ME, Näppi J, Harris GJ, Yoshida H: Structure-analysis method for electronic cleansing in cathartic and noncathartic CT colonography. Med Phys; 2008 Jul;35(7):3259-77
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  • Evaluation of the quality of the cleansing based on polyps and folds in a colon phantom, as well as on polyps in clinical cathartic and noncathartic CTC cases with fluid and stool tagging, showed that our structure-analysis cleansing method is significantly superior to that of our previous thresholding-based EC method.
  • [MeSH-minor] Algorithms. Colonic Polyps / diagnosis. Colonic Polyps / pathology. Colonoscopy / methods. Contrast Media / pharmacology. Feces. Humans. Imaging, Three-Dimensional. Models, Statistical. Normal Distribution. Phantoms, Imaging. Tomography, X-Ray Computed / methods. X-Rays

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  • (PMID = 18697551.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA095279; United States / NCI NIH HHS / CA / R56 CA095279; United States / NCI NIH HHS / CA / CA095279
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cathartics; 0 / Contrast Media
  • [Other-IDs] NLM/ PMC2809717
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83. Pranesh N, Haboubi NY, O'Dwyer ST: Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch. Ann R Coll Surg Engl; 2005 Jul;87(4):W1-4
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  • [Title] Pigmented mesenteric lymphadenopathy in familial adenomatous polyposis - an unusual cause of intraoperative abandonment of ileo-anal pouch.
  • Familial adenomatous polyposis (FAP) is an autosomal dominant condition with near complete penetrance, characterised by the presence of numerous adenomatous polyps of the colon and rectum.
  • We report a unique case of FAP with melanosis pigment in lymph nodes in the small bowel mesentery that initially prevented a restorative proctocolectomy but that resolved following a colectomy, subsequently facilitating formation of an ileo-anal pouch.


84. Martino P, Martino D, Palazzo S, Altomare DF, Garofalo L, Battaglia M, Selvaggi FP: Incidental discovery of ano-rectal disease during transrectal ultrasound performed for prostatic disease. Arch Ital Urol Androl; 2005 Mar;77(1):37-9
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  • In 132 cases (27%) it was shown to be a false positive, mainly due to imperfect cleansing of the anal canal; in 284 cases (58%) benign disease was demonstrated (hemorrhoids in 192 patients, abscesses in 21, perianal fistulas in 18, inflamed lymph nodes in 27, polyps in 16).
  • It can be concluded that transrectal US does not permit a certain diagnosis of the nature of rectal disease, but does raise a diagnostic suspicion that can orient the surgeon to schedule more invasive diagnostic investigations.

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  • (PMID = 15906788.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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85. Ramirez JM, Aguilella V, Gracia JA, Ortego J, Escudero P, Valencia J, Esco R, Martinez M: Local full-thickness excision as first line treatment for sessile rectal adenomas: long-term results. Ann Surg; 2009 Feb;249(2):225-8
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  • There are many techniques for local removal of rectal polyps.
  • No statistical differences were found when comparing the histologic findings by tumor size, distance to the anal verge, or location.In 10 (5.8%) cases, the dissection was considered uncompleted because of a normal mucosa margin smaller than 1 mm.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Female. Humans. Male. Microsurgery. Middle Aged. Proctoscopy. Risk Factors. Young Adult

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  • (PMID = 19212174.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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86. Carlo P, Paolo RF, Carmelo B, Salvatore I, Giuseppe A, Giacomo B, Antonio R: Colonoscopic evaluation of hematochezia in low and average risk patients for colorectal cancer: a prospective study. World J Gastroenterol; 2006 Dec 7;12(45):7304-8
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  • Findings were the presence of polyps in the distal colon (n = 2) and IBD in the proximal colon (n = 29) in the group of the younger patients, and polyps (n = 15), IBD (n = 13), and carcinoma (n = 6, 4 of the lesions were located proximal to the splenic flexure) in the elderly.
  • Regarding the patients older than 45 yr, the exploration of the distal colon would have led to our overlooking a carcinoma, two neoplastic polyps and one IBD located in the proximal colon.
  • CONCLUSION: Young patients with scant hematochezia but without risk factors for neoplasia do not need a total colonoscopy, whereas is mandatory performing a total colonoscopy in older patients even in the presence of anal pathology.
  • [MeSH-major] Colonoscopy / methods. Colorectal Neoplasms / epidemiology. Gastrointestinal Hemorrhage / diagnosis


87. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM: Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2006 Aug;4(8):1035-8
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  • BACKGROUND & AIMS: Familialadenomatous polyposis (FAP) is an autosomal-dominant disorder characterized by the development of hundreds of colorectal adenomas and eventual colorectal cancer.
  • METHODS: Five FAP patients with prior colectomy (4 with retained rectum and 1 with an ileal anal pouch) received curcumin 480 mg and quercetin 20 mg orally 3 times a day.
  • The number and size of polyps were assessed at baseline and after therapy.
  • The Wilcoxon signed-rank test was used to determine differences in the number and size of polyps.
  • RESULTS: All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin.
  • The mean percent decrease in the number and size of polyps from baseline was 60.4% (P < .05) and 50.9% (P < .05), respectively.


88. Winter L, Bruhn H, Langrehr J, Neuhaus P, Felix R, Hänninen LE: Magnetic resonance imaging in suspected rectal cancer: determining tumor localization, stage, and sphincter-saving resectability at 3-Tesla-sustained high resolution. Acta Radiol; 2007 May;48(4):379-87
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  • Transverse T2-weighted fast spin-echo images compared superiorly to all other sequences for the diagnosis of mesorectal infiltration and lymph node involvement.
  • [MeSH-major] Anal Canal / surgery. Image Processing, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenomatous Polyps / diagnosis. Adenomatous Polyps / pathology. Adenomatous Polyps / surgery. Aged. Contrast Media. Cytomegalovirus Infections / diagnosis. Fascia / pathology. Humans. Image Enhancement / methods. Lymphatic Metastasis / diagnosis. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Preoperative Care. Proctitis / diagnosis. Proctitis / virology. Prospective Studies. Rectum / pathology. Sensitivity and Specificity

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  • (PMID = 17453515.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media
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89. Ramakrishnan K, Scheid DC: Selecting patients for flexible sigmoidoscopy. Determinants of incomplete depth of insertion. Cancer; 2005 Mar 15;103(6):1179-85
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  • Incomplete depth of insertion (IDI) during FS may result in missed polyps and carcinomas.
  • A questionnaire was administered to the patient by the investigator prior to FS to collect data, including age, gender, weight, comorbid illnesses, history of prior abdominal and pelvic surgeries, family history of colon carcinoma or polyps, and prior FS or colonoscopies.
  • The depth of insertion of the flexible sigmoidoscope from the anal verge, which was defined as the reading on the outside of the instrument at its maximal insertion, was measured in centimeters.
  • [MeSH-major] Colorectal Neoplasms / diagnosis. Sigmoidoscopes. Sigmoidoscopy / methods

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  • (PMID = 15674852.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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90. Mönkemüller K, Fry LC, Neumann H, Rickes S, Malfertheiner P: [Diagnostic and therapeutic utility of double balloon endoscopy: experience with 225 procedures]. Acta Gastroenterol Latinoam; 2007 Dec;37(4):216-23
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  • RESULTS: 225 DBE in 178 patients, (95 males, 83 females; mean age 59 years-old, range 12-93); oral route (n=160), anal (n=65).
  • Indications (one or more per patient): GI bleeding (n=83), suspected Crohn's disease or evaluation of small bowel involvement or complications (n=35), diarrhea or malabsorption or suspected celiac disease (n=11), polyp removal in Peutz-Jeghers' syndrome or familial polyposis (n=23), tumor surveillance or search of primary tumor (n=14), abdominal pain (n=6) and miscellaneous (n=6).
  • The mean depth of insertion via the oral route was 240 cm (range 20 cm to 650 cm) and via the anal route it was 65 cm (range 10 cm a 150 cm).
  • A new diagnosis was reached in 108/178 patients (60%).
  • Findings included: angiodysplasia, ulcerations, stenosis, polyps, portal jejunopathy, ischemic jejunitis and normal.
  • CONCLUSIONS: DBE was clinically useful for reaching a new diagnosis and to start new therapies, change existing therapies, and perform an operative intervention or to provide therapeutic endoscopy in two-thirds of the investigated patients.
  • DBE is a useful and safe method to obtain tissue for diagnosis, to provide hemostasis and to perform polypectomy.
  • [MeSH-major] Catheterization / methods. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis

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  • [CommentIn] Acta Gastroenterol Latinoam. 2007 Dec;37(4):204, 271 [18254254.001]
  • (PMID = 18254259.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Argentina
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91. Yao J, Li J, Summers RM: EMPLOYING TOPOGRAPHICAL HEIGHT MAP IN COLONIC POLYP MEASUREMENT AND FALSE POSITIVE REDUCTION. Pattern Recognit; 2009;42(6):1029-1040
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  • [Title] EMPLOYING TOPOGRAPHICAL HEIGHT MAP IN COLONIC POLYP MEASUREMENT AND FALSE POSITIVE REDUCTION.
  • Inspired by the way radiologists detect polyps via 3D virtual fly-through in CTC, we borrowed the idea from geographic information systems to employ topographical height map in colonic polyp measurement and false positive reduction.
  • We design a concentric index to characterize the concentric pattern in polyp height map based on the fact that polyps are protrusions from the colon wall and round in shape.
  • We have trained our method on 394 patients (71 polyps) and tested it on 792 patients (226 polyps).
  • We compute the polyp height and width measurements and correlate them with manual measurements.

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  • (PMID = 19578483.001).
  • [ISSN] 0031-3203
  • [Journal-full-title] Pattern recognition
  • [ISO-abbreviation] Pattern Recognit
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CL999999
  • [Publication-type] Journal Article
  • [Publication-country] England
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92. Bemelman WA: Minimally invasive surgery for early lower GI cancer. Best Pract Res Clin Gastroenterol; 2005 Dec;19(6):993-1005
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • After installation of a pneumorectum, lesions up to 25 cm from the anal verge, including circumferential lesions, can be removed with a recurrence rate of 0-5% for adenomas, 3% for low-risk T1 carcinomas, and 8% for all carcinomas.
  • [MeSH-minor] Adenomatous Polyps / surgery. Colonoscopy. Humans. Laparoscopy. Rectum / surgery

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  • (PMID = 16338654.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 57
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93. Ye X, Beddoe G, Slabaugh G: Automatic Graph Cut Segmentation of Lesions in CT Using Mean Shift Superpixels. Int J Biomed Imaging; 2010;2010:983963
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  • Visual inspection on different types of lesions (lung nodules and colonic polyps), as well as a quantitative evaluation on 101 solid and 80 GGO nodules, both demonstrate the potential of the proposed method.

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  • (PMID = 21052498.001).
  • [ISSN] 1687-4196
  • [Journal-full-title] International journal of biomedical imaging
  • [ISO-abbreviation] Int J Biomed Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2967838
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94. Leung KK, Yusuf TE: External polypectomy of a large anal canal polyp. Gastrointest Endosc; 2007 Sep;66(3):603; discussion 604
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] External polypectomy of a large anal canal polyp.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anus Neoplasms / surgery. Intestinal Polyps / surgery. Rectal Neoplasms / surgery

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  • (PMID = 17681501.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Ooi BS, Quah HM, Fu CW, Eu KW: Laparoscopic high anterior resection with natural orifice specimen extraction (NOSE) for early rectal cancer. Tech Coloproctol; 2009 Mar;13(1):61-4
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  • The patient, a 51-year-old male (BMI 18.6 kg/m(2)) with a 2.5-cm, early-stage posterior rectal cancer 12 cm from the anal verge, underwent the above-described procedure.
  • [MeSH-major] Colectomy / methods. Colon / surgery. Laparoscopy / methods. Polyps / surgery. Rectal Neoplasms / surgery. Rectum / surgery

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  • (PMID = 19288243.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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96. Orbell J, West NJ: Improving detection of colorectal cancer. Practitioner; 2010 Oct;254(1733):17-21, 2-3
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  • Adenomas are more common with age and one in four of the population aged over 50 will develop one or more polyps, with 10% of these polyps progressing to cancer over time.
  • Rectal bleeding in the absence of anal symptoms occurs in over 60% of those with cancer, and a palpable rectal mass with or without tenesmus is present in 40-80% of those with rectal cancer.
  • [MeSH-major] Colorectal Neoplasms / diagnosis


97. Casadesus D: Surgical resection of rectal adenoma: a rapid review. World J Gastroenterol; 2009 Aug 21;15(31):3851-4
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  • Transanal excision (TE), endoscopic transanal resection (ETAR) and transanal endoscopic microsurgery (TEM) can be used to remove adenomatous polyps.
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / surgery. Digestive System Surgical Procedures / adverse effects. Digestive System Surgical Procedures / methods. Endoscopy / methods. Humans. Microsurgery / methods. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Rectum / pathology. Rectum / surgery

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  • (PMID = 19701964.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 41
  • [Other-IDs] NLM/ PMC2731246
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98. Rao VS, Ahmad N, Al-Mukhtar A, Stojkovic S, Moore PJ, Ahmad SM: Comparison of rigid vs flexible sigmoidoscopy in detection of significant anorectal lesions. Colorectal Dis; 2005 Jan;7(1):61-4
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  • Of the 115 (75.6%) declared normal by RS, 39 (33.9%) had significant lesions including 7 polyps and 4 malignant lesions within 20 cm of the anal verge during FS.
  • Of the 31 patients (20.4%) in whom RS was not helpful due to faecal loading, 15 (48.4%) had significant lesions including 4 malignancies and 1 polyp --all within 20 cm of the anal verge during FS.
  • Only 2 polyps and 1 malignant lesion were picked up by both flexible and rigid sigmoidoscopy.

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  • (PMID = 15606587.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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99. Schäfer HH, Vivaldi C, Hölscher AH: [Local excision with transanal endoscopic microsurgery (TEM) after endoscopic R1/R2-polypectomy of pT1 "low-risk" carcinomas of the rectum]. Z Gastroenterol; 2006 Aug;44(8):647-50
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  • The transanal endoscopic microsurgery (TEM) is an adequate method for the local full-thickness excision of large rectum polyps and pT1 "low-risk" rectal carcinomas.
  • We studied prospectively the relevance of this surgical technique concerning complete tumour excision after R1/R2-polypectomy of malignant rectal polyps.
  • [MeSH-major] Intestinal Polyps / surgery. Microsurgery / methods. Neoplasm Recurrence, Local / prevention & control. Proctoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / surgery. Female. Humans. Male. Middle Aged. Risk Assessment / methods. Risk Factors. Treatment Outcome

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 16902894.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
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100. Suenaga M, Oya M, Ueno M, Yamamoto J, Yamaguchi T, Mizunuma N, Hatake K, Kato Y, Muto T: Anal canal carcinoma with Pagetoid spread: report of a case. Surg Today; 2006;36(7):666-9
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  • [Title] Anal canal carcinoma with Pagetoid spread: report of a case.
  • A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal.
  • Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal.
  • Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin.
  • Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion.
  • Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma.
  • This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.
  • [MeSH-minor] Adenocarcinoma. Aged. Anal Canal / pathology. Anus Neoplasms. Humans. Male

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  • (PMID = 16794808.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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