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1. Galanis I, Dragoumis D, Tsolakis M, Zarampoukas K, Zarampoukas T, Atmatzidis K: Obstructive ileus due to a giant fibroepithelial polyp of the anus. World J Gastroenterol; 2009 Aug 7;15(29):3687-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obstructive ileus due to a giant fibroepithelial polyp of the anus.
  • Fibroepithelial polyps or hypertrophied anal papillae are essentially skin tags that project up from the dentate line and the junction between the skin and the epithelial lining of the anus.
  • An extremely rare case of a giant hypertrophied anal papilla complicated by obstructive ileus is reported.
  • Fibroepithelial anal polyp, despite its size, should be included in the differential diagnosis of a smooth mass located near the anal verge, especially in a patient with a history of chronic anal irritation or infection.
  • [MeSH-major] Anus Neoplasms / complications. Ileus / etiology. Intestinal Polyps / complications. Neoplasms, Fibroepithelial / complications
  • [MeSH-minor] Aged. Anal Canal / pathology. Female. Humans

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  • (PMID = 19653351.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2721247
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2. Rifat Mannan AA, Kahvic M, Bharadwaj S, Grover VK: Gastric heterotopia of the anus: report of two rare cases and review of the literature. Indian J Pathol Microbiol; 2008 Apr-Jun;51(2):240-1
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  • [Title] Gastric heterotopia of the anus: report of two rare cases and review of the literature.
  • We report two cases of gastric heterotopia in the anus - one, in a 55-year-old man; and the other, in a 35-year-old woman.
  • Sigmoidoscopy showed presence of a single sessile anal polyp in the first patient and hemorrhoid in the other.
  • [MeSH-major] Anus Diseases / pathology. Choristoma / pathology. Gastric Mucosa

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  • (PMID = 18603693.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 9
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3. Chan NG, Penswick JL, Labelle E, Driman DK: Ectopic breast tissue presenting as an anal polyp. Can J Surg; 2007 Dec;50(6):E23-4
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  • [Title] Ectopic breast tissue presenting as an anal polyp.
  • [MeSH-major] Anus Diseases / pathology. Breast. Choristoma / pathology

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  • (PMID = 18067696.001).
  • [ISSN] 1488-2310
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2386226
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4. Maruani A, Bonneau C, Vaur JL, Maitre F: [A peculiar case of anal polyp]. Ann Pathol; 2005 Feb;25(1):69-70
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  • [Title] [A peculiar case of anal polyp].
  • [Transliterated title] Un cas particulier de polype anal.
  • [MeSH-major] Anus Neoplasms / pathology. Neoplasms, Fibroepithelial / pathology. Polyps / pathology

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  • (PMID = 15981938.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Vimentin
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5. Ewertsen C, Svendsen CB, Svendsen LB, Mogensen AM: [Inflammatory cloacogenic polyp]. Ugeskr Laeger; 2008 Aug 25;170(35):2708
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  • [Title] [Inflammatory cloacogenic polyp].
  • [Transliterated title] Inflammatorisk kloakogen polyp.
  • We present a case of inflammatory cloacogenic polyp in a 28-year-old man who had suffered from intermittent rectal bleeding for four years.
  • A colonoscopy showed anal polyps.
  • The patient had no previous medical history and had no known family history of polyps.
  • Histopathology showed changes in the colonic mucous membrane consistent with the diagnosis inflammatory cloacogenic polyp, no dysplasia.
  • [MeSH-major] Anus Neoplasms / pathology. Intestinal Polyps / pathology
  • [MeSH-minor] Adult. Colonoscopy. Diagnosis, Differential. Gastrointestinal Hemorrhage / diagnosis. Humans. Intestinal Mucosa / pathology. Male. Rectal Diseases / diagnosis

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  • (PMID = 18761864.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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6. Gholam P, Autschbach F, Hartschuh W: Schistosomiasis in an HIV-positive patient presenting as an anal fissure and giant anal polyp. Arch Dermatol; 2008 Jul;144(7):950-2
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  • [Title] Schistosomiasis in an HIV-positive patient presenting as an anal fissure and giant anal polyp.
  • [MeSH-major] Anus Diseases / diagnosis. Fissure in Ano / diagnosis. HIV Infections. Schistosomiasis / diagnosis
  • [MeSH-minor] Adult. Animals. Anthelmintics / administration & dosage. Anthelmintics / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Polyps / diagnosis. Polyps / drug therapy. Polyps / pathology. Polyps / surgery. Praziquantel / administration & dosage. Praziquantel / therapeutic use. Schistosoma mansoni / isolation & purification. Viral Load

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  • (PMID = 18645157.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthelmintics; 6490C9U457 / Praziquantel
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7. Papadopoulos IN, Danias N, Zoumpouli CK: Fibroepithelial polyp in an anal fistulous track: a sign of chronic pathology. BMJ Case Rep; 2010;2010

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  • [Title] Fibroepithelial polyp in an anal fistulous track: a sign of chronic pathology.
  • Hypertrophied anal papillae and fibroepithelial polyps are benign acquired polypoid lesions of the anal canal.
  • The development and protrusion of a fibroepithelial polyp in an anal fistulous track is described.
  • This is a rare physical sign of chronic anal pathology.

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  • [ErratumIn] BMJ Case Rep. 2010;2010:doi/10.1136/bcr.08.2009.2169corr1. Zoumpouli, Christine K [added]
  • (PMID = 22242043.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3027388
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8. Wang S, Yao J, Summers RM: Improved classifier for computer-aided polyp detection in CT colonography by nonlinear dimensionality reduction. Med Phys; 2008 Apr;35(4):1377-86
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  • [Title] Improved classifier for computer-aided polyp detection in CT colonography by nonlinear dimensionality reduction.
  • Computer-aided detection (CAD) has been shown to be feasible for polyp detection on computed tomography (CT) scans.
  • After initial detection, the dataset of colonic polyp candidates has large-scale and high dimensional characteristics.
  • We applied the proposed DMLLE method to a colonic polyp dataset of 175 269 polyp candidates with 155 features.
  • Visual inspection shows that true polyps with similar shapes are mapped to close vicinity in the low dimensional space.
  • For 6-9 mm polyps (193 true polyps contained in test set), when the number of false positives per patient is 9, SVM with DMLLE improves the average sensitivity from 70% to 83% compared with that of an SVM committee classifier which is a state-of-the-art method for colonic polyp detection (p<0.001).
  • [MeSH-major] Algorithms. Artificial Intelligence. Colonic Polyps / diagnostic imaging. Colonography, Computed Tomographic / methods. Pattern Recognition, Automated / methods. Radiographic Image Interpretation, Computer-Assisted / methods

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  • (PMID = 18491532.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CL999999
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS101228; NLM/ PMC2669284
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9. Calva-Rodríguez R, González-Palafox MA, Rivera-Domínguez ME, García-Salazar JM, Calva-Cerqueira Bc D: [Inflammatory cloacogenic polyp]. Rev Gastroenterol Mex; 2007 Oct-Dec;72(4):371-5
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  • [Title] [Inflammatory cloacogenic polyp].
  • INTRODUCTION: Cloacogenic Polyps are characterized by the presence of inflammatory lesions in the lower rectum, and the anal transition zone.
  • The polyps can prolaps; this is due to the malfunction of the internal anal sphincter; and the smooth muscle that covers the rectum.
  • 85% lesions are located above the anal border and predominantly in the anterior lateral wall.
  • The polyps vary in size from 3-4 cm in diameter, and have a sessile appearance.
  • CONCLUSIONS: This entity of colon polyps is somewhat rare, and is seen in young adults; however its presence in infancy requires that we think of this entity when we formulate our differential diagnosis.
  • [MeSH-major] Intestinal Polyps / diagnosis. Rectal Diseases / diagnosis

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  • (PMID = 18595326.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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10. Suenaga M, Oya M, Ueno M, Yamamoto J, Yamaguchi T, Mizunuma N, Hatake K, Kato Y, Muto T: Anal canal carcinoma with Pagetoid spread: report of a case. Surg Today; 2006;36(7):666-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal carcinoma with Pagetoid spread: report of a case.
  • A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal.
  • Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal.
  • Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin.
  • Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion.
  • Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma.
  • This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.
  • [MeSH-minor] Adenocarcinoma. Aged. Anal Canal / pathology. Anus Neoplasms. Humans. Male

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  • (PMID = 16794808.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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11. Duncan JE, McNally MP, Sweeney WB, Gentry AB, Barlow DS, Jensen DW, Cash BD: CT colonography predictably overestimates colonic length and distance to polyps compared with optical colonoscopy. AJR Am J Roentgenol; 2009 Nov;193(5):1291-5
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  • [Title] CT colonography predictably overestimates colonic length and distance to polyps compared with optical colonoscopy.
  • OBJECTIVE: The purpose of this study was to determine the discrepancy between CT colonography (CTC) and optical colonoscopy (OC) measurements for both anus-to-cecum length and anus-to-polyps distance and then determine whether a conversion factor could be generated to equate these CTC and OC distances.
  • The anus-to-cecum measurement recorded on a single proprietary CTC workstation was compared with the OC cecal length for each patient.
  • Likewise, anus-to-polyp distances were compared as measured by the radiologist and endoscopist.
  • RESULTS: Three hundred thirty-eight patients and 437 polyps were identified with complete data from both CTC and same-day OC.
  • The average anus-to-cecum distance measured at CTC was 189 cm (range, 75-257 cm) and at OC, 108 cm (range, 65-150 cm).
  • For polyps proximal to the splenic flexure (n = 145), the CTC anus-to-polyp measurement was on average 1.7 times that measured at OC.
  • For left-sided polyps (n = 292), the CTC measurement was, on average, within 12 cm or 1.3 times that of the OC anus-to-polyp measurement.
  • All the differences between CTC and OC measurements of cecal length and polyp distances were found to be statistically significant using a paired Student's t test of means (p < 0.001).
  • CONCLUSION: Anus-to-cecum and anus-to-polyp distances are disparate but comparable using a conversion factor of 0.57 for the CTC anus-to-cecum measurement and 0.59 for right-sided CTC anus-to-polyp or 0.78 for left-sided CTC anus-to-polyp measurements.
  • These anus-to-polyp conversion factors could potentially augment current CTC guidelines for accurate and precise polyp localization and removal at endoscopy.
  • [MeSH-major] Colonic Polyps / diagnosis. Colonography, Computed Tomographic / methods. Colonoscopy / methods
  • [MeSH-minor] Adult. Aged. Anal Canal / pathology. Anal Canal / radiography. Colon / pathology. Colon / radiography. Female. Humans. Male. Middle Aged. Radiographic Image Interpretation, Computer-Assisted. Retrospective Studies

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  • [CommentIn] AJR Am J Roentgenol. 2009 Nov;193(5):1289-90 [19843743.001]
  • (PMID = 19843744.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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12. Sundaram P, Zomorodian A, Beaulieu C, Napel S: Colon polyp detection using smoothed shape operators: preliminary results. Med Image Anal; 2008 Apr;12(2):99-119
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  • [Title] Colon polyp detection using smoothed shape operators: preliminary results.
  • Computer-aided detection (CAD) algorithms identify locations in computed tomographic (CT) images of the colon that are most likely to contain polyps.
  • We evaluate our algorithm on patient data and provide free-response receiver-operating characteristic performance analysis over all size ranges of polyps.
  • A preliminary evaluation of our method on 35 patients yielded the following results (polyp diameter range; sensitivity; false positives/case): (10mm; 100%; 17.5), (5-10 mm; 89.7%, 21.23), (<5 mm; 59.1%; 23.9) and (overall; 80.3%; 23.9).

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  • (PMID = 17910934.001).
  • [ISSN] 1361-8423
  • [Journal-full-title] Medical image analysis
  • [ISO-abbreviation] Med Image Anal
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / U54 GM072970; United States / NCI NIH HHS / CA / R01 CA72023
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Netherlands
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13. Summers RM: Polyp size measurement at CT colonography: what do we know and what do we need to know? Radiology; 2010 Jun;255(3):707-20
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  • [Title] Polyp size measurement at CT colonography: what do we know and what do we need to know?
  • Polyp size is a critical biomarker for clinical management.
  • Larger polyps have a greater likelihood of being or of becoming an adenocarcinoma.
  • To balance the referral rate for polypectomy against the risk of leaving potential cancers in situ, sizes of 6 and 10 mm are increasingly being discussed as critical thresholds for clinical decision making (immediate polypectomy versus polyp surveillance) and have been incorporated into the consensus CT Colonography Reporting and Data System (C-RADS).
  • Polyp size measurement at optical colonoscopy, pathologic examination, and computed tomographic (CT) colonography has been studied extensively but the reported precision, accuracy, and relative sizes have been highly variable.
  • This review summarizes current best practices for polyp size measurement, describes the role of automated size measurement software, discusses how to manage the measurement uncertainties, and identifies areas requiring further research.

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  • [Copyright] Copyright RSNA, 2010
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  • (PMID = 20501711.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] ENG
  • [Grant] United States / CLC NIH HHS / CL / Z01 CL040003
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 76
  • [Other-IDs] NLM/ PMC2875919
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14. Heyn J, Placzek M, Ozimek A, Baumgaertner AK, Siebeck M, Volkenandt M: Malignant melanoma of the anal region. Clin Exp Dermatol; 2007 Sep;32(5):603-7
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  • [Title] Malignant melanoma of the anal region.
  • Malignant melanoma (MM) of the anal region is an uncommon disease.
  • In many cases, the disease is undetected or mistaken for a benign polyp or haemorrhoids until it reaches an advanced state.
  • Owing to delayed diagnosis and early metastases, the prognosis is often poor.
  • Anorectal melanomas (AM) are most common in the rectum, followed by the anal canal and anal verge.
  • The diagnosis of an AM is usually made using a biopsy.
  • We report on a 39-year old man who presented with a 5-week history of recurrent prolapse of an anal tumour.
  • [MeSH-major] Anus Neoplasms. Melanoma
  • [MeSH-minor] Adult. Angiogenesis Inhibitors / therapeutic use. Cancer Vaccines / therapeutic use. Diagnosis, Differential. Humans. Interferon-alpha / therapeutic use. Male. Prognosis. Treatment Outcome

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  • (PMID = 17376215.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Cancer Vaccines; 0 / Interferon-alpha
  • [Number-of-references] 25
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15. Liu J, Yao J, Summers RM: Scale-based scatter correction for computer-aided polyp detection in CT colonography. Med Phys; 2008 Dec;35(12):5664-71
The Lens. Cited by Patents in .

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  • [Title] Scale-based scatter correction for computer-aided polyp detection in CT colonography.
  • CT colonography (CTC) is a feasible and minimally invasive method for the detection of colorectal polyps and cancer screening.
  • Computer-aided detection (CAD) of polyps can improve consistency and sensitivity of virtual colonoscopy interpretation and reduce interpretation burden.
  • This pseudoenhancement phenomenon presents a problem for the application of computer-aided polyp detection, especially when polyps are submerged in the contrast agents.
  • There were 50 colonoscopy-confirmed polyps measuring 6-9 mm.
  • Visual evaluation indicated that the method reduced CT attenuation of pseudoenhanced polyps to the usual polyp Hounsfield unit range without affecting luminal air regions.
  • For polyps submerged in contrast agents, the sensitivity of CAD with correction is increased 24% at a rate of ten false-positive detections per scan.
  • For all polyps within 6-9 mm, the sensitivity of the authors' CAD with scatter correction is increased 8% at a rate of ten false-positive detections per scan.
  • [MeSH-major] Colon / diagnostic imaging. Colonography, Computed Tomographic / methods. Diagnosis, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Algorithms. Automation. Colonoscopy / methods. Contrast Media / pharmacology. False Positive Reactions. Humans. Pattern Recognition, Automated. Polyps. Radiographic Image Interpretation, Computer-Assisted / methods. Reproducibility of Results. Scattering, Radiation

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  • (PMID = 19175123.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
  • [Other-IDs] NLM/ NIHMS84353; NLM/ PMC2644449
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16. Shin A, Shrubsole MJ, Rice JM, Cai Q, Doll MA, Long J, Smalley WE, Shyr Y, Sinha R, Ness RM, Hein DW, Zheng W: Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk. Cancer Epidemiol Biomarkers Prev; 2008 Feb;17(2):320-9
Pharmacogenomics Knowledge Base. meta-databases - Pharmacogenomic Annotation 981802734 for PMID:18268115 [PharmGKB] .

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  • [Title] Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.
  • Most colorectal cancers arise from adenomatous polyps or certain hyperplastic polyps.
  • Only a few studies have investigated potential genetic modifiers of the associations between meat intake and polyp risk, and results are inconsistent.
  • Using data from the Tennessee Colorectal Polyp Study, a large colonoscopy-based study, including 1,002 polyp cases (557 adenoma only, 250 hyperplastic polyp only, 195 both polyps) and 1,493 polyp-free patients, we evaluated the association of colorectal polyp risk with carcinogen exposure from meat and genetic polymorphisms in enzymes involved in heterocyclic amine (HCA) metabolism, including N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2), cytochrome P450 1A2 (CYP1A2), and aryl hydrocarbon receptor (AhR).
  • No clear association was found for any polymorphisms with polyp risk.
  • However, apparent interactions were found for intake of meat and HCAs with AhR, NAT1, and NAT2 genotypes, and the interactions were statistically significant for the group with both adenomatous and hyperplastic polyps.
  • These results provide strong evidence for a modifying effect of metabolizing genes on the association of meat intake and HCA exposure with colorectal polyp risk.

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  • (PMID = 18268115.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA950103; United States / NCI NIH HHS / CA / P50 CA095103; United States / NCI NIH HHS / CA / CA095103-010005; United States / NCI NIH HHS / CA / R01 CA097386-01; United States / NCI NIH HHS / CA / R01 CA097386; United States / NCI NIH HHS / CA / R01 CA034627; United States / NCI NIH HHS / CA / CA097386-01; United States / NCI NIH HHS / CA / R01 CA34627; United States / NCI NIH HHS / CA / R01 CA034627-15; United States / NCI NIH HHS / CA / P50 CA095103-010005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Aryl Hydrocarbon; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 2.3.1.- / Acetyltransferases
  • [Other-IDs] NLM/ NIHMS72769; NLM/ PMC2572782
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17. Albright JB, Bonatti H, Stauffer J, Dickson RC, Nguyen J, Harnois D, Jeanpierre C, Hinder R, Steers J, Chua H, Aranda-Michel J: Colorectal and anal neoplasms following liver transplantation. Colorectal Dis; 2010 Jul;12(7):657-66
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  • [Title] Colorectal and anal neoplasms following liver transplantation.
  • Data on neoplasms of the colon, rectum and anus in LT are limited.
  • METHOD: A retrospective evaluation of the incidence and clinical course of colorectal and anal malignancies and colonic polyps in a series of 467 consecutive LTs in 402 individuals between 1998 and 2001 was performed.
  • RESULTS: During a median follow up of 5.2 years, three colon adenocarcinomas, one EBV associated cecal posttransplant lymphoproliferative tumour and two HPV associated anal tumours were identified.
  • Pre-LT colonoscopy was performed in 161 patients (40%), and of 153 evaluable individuals, 53 (34.9%) had polyps.
  • Colonoscopy was performed in 186 patients (46.3%) median 14.8 (range 0.2-77.8) months post-LT and 55 (29.3%) had polyps.
  • Post-LT adenomatous polyps were detected in 47.3% of patients with pre-LT polyps vs 6.7% of patients without pre-LT polyps (P < 0.001).
  • No patient died from colorectal/anal malignancy.
  • CONCLUSION: The incidence of metachronous and new polyp formation in our study is similar to people who are not immunocompromised, but subgroups are at increased risk.
  • Viral-associated malignancies, including post-transplant lymphoproliferative disorders and anal cancer, are important entities in the LT population suggesting that complete screening of the colon, rectum and anus including pre-LT and post-LT colonoscopy should be utilized.
  • [MeSH-major] Anus Neoplasms / epidemiology. Colonic Neoplasms / epidemiology. Immunosuppression / adverse effects. Liver Transplantation

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  • (PMID = 19508543.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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18. Tony J, Saji S, Sandesh K, Sunilkumar K, Ramachandran TM, Thomas V: External resection of a giant sigmoid lipoma causing colonic intussusception and prolapse through the anal canal. Trop Gastroenterol; 2007 Jul-Sep;28(3):127-8
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  • [Title] External resection of a giant sigmoid lipoma causing colonic intussusception and prolapse through the anal canal.
  • Sigmoidoscopy revealed a large globular pedunculated polyp at 22 cm from the anal verge resulting in a sigmoidorectal intussusception.
  • Endoscopic polypectomy was not technically possible due to the large size of the polyp.
  • At the time of prolapse the polyp was tied at its pedicle with thread and resected surgically.

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  • (PMID = 18384003.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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19. Pirog EC, Quint KD, Yantiss RK: P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction. Am J Surg Pathol; 2010 Oct;34(10):1449-55
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  • [Title] P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction.
  • The classification of anal intraepithelial neoplasia (AIN) in mucosal biopsies is subject to considerable interobserver variability.
  • The aim of this study was to determine whether Ki-67 and p16/CDKN2A immunolabeling enhanced diagnostic accuracy in the assessment of anal mucosal biopsies from patients with suspected human papillomavirus (HPV) infection.
  • The study consisted of 75 cases that were originally interpreted to represent normal anal transitional zone (n=15), fibroepithelial polyp (n=10), condyloma accuminatum (n=10), low-grade AIN (AIN1, n=20), and high-grade AIN (n=20), including 10 cases each of AIN2 and AIN3.
  • Thus, the final study group consisted of 17 samples of normal anal transition zone, 14 fibroepithelial polyps, 6 condylomata accuminata, and 38 cases of AIN (11 AIN1, 16 AIN2, and 11 AIN3).
  • None of the anal transition zone samples or fibroepithelial polyps showed Ki-67 or p16/CDKN2A staining.
  • We conclude that Ki-67 labeling detects anal HPV-related changes with a high degree of sensitivity and specificity, whereas increased p16/CDKN2A staining is strongly associated with high-grade squamous neoplasia.
  • These results indicate that a combination of these markers may aid interpretation of anal mucosal biopsy samples.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Condylomata Acuminata / diagnosis. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ki-67 Antigen / metabolism. Papillomaviridae / isolation & purification. Papillomavirus Infections / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Biopsy. Colonic Polyps / metabolism. Colonic Polyps / pathology. Colonic Polyps / virology. DNA Probes, HPV. Female. Humans. Immunohistochemistry. Male. Middle Aged. Precancerous Conditions / diagnosis. Precancerous Conditions / metabolism. Precancerous Conditions / virology. Predictive Value of Tests. Young Adult

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  • (PMID = 20871219.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA Probes, HPV; 0 / Ki-67 Antigen
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20. Danova NA, Robles-Emanuelli JC, Bjorling DE: Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs. Vet Surg; 2006 Jun;35(4):337-40
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  • [Title] Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs.
  • OBJECTIVE: To describe an anal approach for excision of primary rectal tumors in dogs and to report outcome.
  • METHODS: Review of medical records (1990-2000) of dogs with primary rectal neoplasia excised surgically using an anal approach with rectal prolapse.
  • RESULTS: Each dog had only 1 tumor type (adenocarcinoma [8], solitary polyp [5], carcinoma [4], plasmacytoma [2], adenoma [1], leiomyoma [1], mucinous carcinoma [1], and papilloma [1]).
  • CONCLUSION: Surgical excision of tumors of the caudal rectum can be accomplished through the anus after rectal prolapse.
  • CLINICAL RELEVANCE: An anal approach facilitated by rectal prolapse should be considered as a viable option for the surgical treatment of selected cases of tumors of the caudal aspect of the rectum in dogs.
  • [MeSH-major] Anal Canal / surgery. Dog Diseases / surgery. Rectal Neoplasms / veterinary
  • [MeSH-minor] Adenocarcinoma / surgery. Adenocarcinoma / veterinary. Animals. Disease-Free Survival. Dogs. Female. Male. Polyps / surgery. Polyps / veterinary. Postoperative Complications / veterinary. Records as Topic / veterinary. Retrospective Studies. Treatment Outcome. Wisconsin / epidemiology

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  • (PMID = 16756613.001).
  • [ISSN] 0161-3499
  • [Journal-full-title] Veterinary surgery : VS
  • [ISO-abbreviation] Vet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Antillon MR, Bartalos CR, Miller ML, Diaz-Arias AA, Ibdah JA, Marshall JB: En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video). Gastrointest Endosc; 2008 Feb;67(2):332-7
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  • [Title] En bloc endoscopic submucosal dissection of a 14-cm laterally spreading adenoma of the rectum with involvement to the anal canal: expanding the frontiers of endoscopic surgery (with video).
  • At a 2.5-week endoscopic follow-up, a 3-mm focus of residual polyp was seen and removed.
  • CONCLUSIONS: This case demonstrated the feasibility of using ESD to remove large laterally spreading rectal tumors, including when there was involvement to the dentate line (and the dissection line must include squamous mucosa of the anal canal).
  • [MeSH-major] Adenoma / surgery. Anal Canal / pathology. Electrocoagulation / methods. Rectal Neoplasms / surgery. Thoracoscopy / methods

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  • (PMID = 18226698.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Gupta PJ: A study of the symptomatology of hypertrophied anal papillae and fibrous anal polyps. Bratisl Lek Listy; 2005;106(1):30-3
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  • [Title] A study of the symptomatology of hypertrophied anal papillae and fibrous anal polyps.
  • BACKGROUND: The presence of Hypertrophied anal papillae and fibrous anal polyps are often ignored in proctology practice.
  • PATIENTS AND METHODS: The study was carried out in 136 patients with chronic anal fissure having concomitant hypertrophied anal papillae or fibrous anal polyps.
  • After relieving sphincter spasm by sphincterotomy, the polyps or papillae were destroyed using the radio frequency device.
  • A comparison was made for the associated complaints like pruritus, pricking sensation, wetness, crawling sensation in the anus etc. before and after the removal of papillae or polyps by an independent observer blinded to the procedure.
  • There was significant reduction in pruritus (p=0.0003), discharge per anus (p=0.0006), crawling sensation in the anus (p=0.0004) and that of incomplete evacuation (p=0.001) At the follow up after 18 months, only 9 % of patients had recurrence of either anal fissure or symptoms like pruritus.
  • CONCLUSION: This study establishes that removal of hypertrophied anal papillae and fibrous polyps should be carried on a routine basis during surgical treatment of anal fissure.
  • [MeSH-major] Anus Diseases / diagnosis. Intestinal Polyps / diagnosis

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  • (PMID = 15869011.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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23. Negoda A, Xian M, Reusch RN: Insight into the selectivity and gating functions of Streptomyces lividans KcsA. Proc Natl Acad Sci U S A; 2007 Mar 13;104(11):4342-6
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  • It has been shown that the polypeptides copurify with two homopolymers, poly[(R)-3-hydroxybutyrate] (PHB) and inorganic polyphosphate (polyP), which have intrinsic capacities for cation selection and transport.
  • PHB/polyP complexes are highly selective for divalent cations when pH is greater than the pK(2) of polyP ( approximately 6.8), but this preference is lost when pH is < or =pK(2).
  • It is postulated that KcsA polypeptides attenuate the divalent negative charge of the polyP end unit at physiological pH by strategic positioning of two C-terminal arginines.
  • Channel gating may be triggered by changes in the balance between the K(+) polyP(-) binding energy, the membrane potential, and the gradient force.
  • The results reveal the importance of the C-terminal arginines to K(+) selectivity and argue for a supramolecular structure for KcsA in which the host polypeptides modify the cation preference of a guest PHB/polyP complex.

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  • (PMID = 17360526.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM054090; United States / NIGMS NIH HHS / GM / GM 054090
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Lipid Bilayers; 0 / Potassium Channels; 0 / prokaryotic potassium channel; 94ZLA3W45F / Arginine; I38ZP9992A / Magnesium; RWP5GA015D / Potassium
  • [Other-IDs] NLM/ PMC1838604
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24. Szyszko TA, Bush J, Gishen P, Sellu D, Desouza NM: Endoanal magnetic resonance imaging of fistula-in-ano: a comparison of STIR with gadolinium-enhanced techniques. Acta Radiol; 2005 Feb;46(1):3-8
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  • Five had no anal pathology, 1 had anal excoriation, and 1 had a polyp.

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  • (PMID = 15841733.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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25. Zakharian E, Reusch RN: Haemophilus influenzae outer membrane protein P5 is associated with inorganic polyphosphate and polyhydroxybutyrate. Biophys J; 2007 Jan 15;92(2):588-93
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  • Chemical and immunological analyses revealed the presence of inorganic polyphosphate (polyP), and the amphiphilic, solvating polyester, poly-(R)-3-hydroxybutyrate, frequently associated with polyP.
  • A sharp reduction in cation selectivity was observed after addition of Saccharomyces cerevisiae exopolyphosphatase X to the bilayer, providing functional evidence for the involvement of polyP in selectivity.
  • The results suggest that NTHi P5 associates with polyP and poly-(R)-3-hydroxybutyrate to create large, cation-selective pores in the outer membrane of H. influenzae.

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  • (PMID = 17056737.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM 05090
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Outer Membrane Proteins; 0 / Hydroxybutyrates; 0 / Inorganic Chemicals; 0 / Lipid Bilayers; 0 / Phospholipids; 0 / Polyesters; 0 / Polyphosphates; 0 / outer membrane protein P5, Haemophilus; 26063-00-3 / poly-beta-hydroxybutyrate
  • [Other-IDs] NLM/ PMC1751419
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26. Sweetser S, Alexander GL, Boardman LA: A case of Cronkhite-Canada syndrome presenting with adenomatous and inflammatory colon polyps. Nat Rev Gastroenterol Hepatol; 2010 Aug;7(8):460-4
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  • [Title] A case of Cronkhite-Canada syndrome presenting with adenomatous and inflammatory colon polyps.
  • DIAGNOSIS: Cronkhite-Canada syndrome.
  • Removal of all visible polyps from the anal verge to 25 cm endoscopically by snare polypectomy or with hot biopsy forceps, followed by subtotal colectomy with end-to-side ileorectostomy.

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  • (PMID = 20628344.001).
  • [ISSN] 1759-5053
  • [Journal-full-title] Nature reviews. Gastroenterology & hepatology
  • [ISO-abbreviation] Nat Rev Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Histamine H2 Antagonists; 0 / Vitamins; VB0R961HZT / Prednisone
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27. Gupta PJ: Radiofrequency surgery--novel techniques in the treatment of ano-rectal disease. Acta Chir Iugosl; 2006;53(2):23-9
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  • OBJECTIVE: This paper discusses author's clinical experience with radiofrequency for various ano-rectal pathologies namely hemorrhoids, anal fistula, anal polyps, sinuses and anal papillae.
  • [MeSH-minor] Anus Diseases / surgery. Humans

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  • (PMID = 17139880.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia and Montenegro
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28. Sayari S, Moussi A, Bel Haj Salah R, Gherib SB, Haouet K, Zaouche A: Primary anorectal melanoma: a case report. Tunis Med; 2010 Jun;88(6):430-2
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  • Rectal examination revealed a tender mass arising from the 5 o'clock position of the anal canal that bled on touch.
  • A provisional diagnosis of rectal polyp was made and it was removed by local excision under general anaesthesia.
  • Abdominoperineal resection has to be done only in the case of large tumors or when the anal sphincter is involved.

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  • (PMID = 20517856.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Tunisia
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29. May A, Schoen M, Nachbar L, Stolte M, Ell C: Ileo-ileal invagination--a cause of recurrent mid-gastrointestinal bleeding: diagnostic and endoscopic therapy by means of push-and-pull enteroscopy. Dig Liver Dis; 2008 Jun;40(6):477-80
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  • Capsule endoscopy suspected an angiodysplasia in the terminal ileum in one patient, in the other two patients a polyp in the region of the ileum as the potential bleeding source was diagnosed.
  • In all three patients, a polyp with an ulcerated tip was found with the anal push-and-pull enteroscopy.

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  • (PMID = 17901004.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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30. Saito K, Ohtomo R, Kuga-Uetake Y, Aono T, Saito M: Direct labeling of polyphosphate at the ultrastructural level in Saccharomyces cerevisiae by using the affinity of the polyphosphate binding domain of Escherichia coli exopolyphosphatase. Appl Environ Microbiol; 2005 Oct;71(10):5692-701
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  • Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate and has many biological functions in prokaryotic and eukaryotic organisms.
  • To investigate polyP localization, we developed a novel technique using the affinity of the recombinant polyphosphate binding domain (PPBD) of Escherichia coli exopolyphosphatase to polyP.
  • Equilibrium binding assay of PPBD revealed its high affinity for long-chain polyP and its weak affinity for short-chain polyP and nucleic acids.
  • To directly demonstrate polyP localization in Saccharomyces cerevisiae on resin sections prepared by rapid freezing and freeze-substitution, specimens were labeled with PPBD containing an epitope tag and then the epitope tag was detected by an indirect immunocytochemical method.
  • When the S. cerevisiae was cultured in yeast extract-peptone-dextrose medium (10 mM phosphate) for 10 h, polyP was distributed in a dispersed fashion in vacuoles in successfully cryofixed cells.
  • A few polyP signals of the labeling were sometimes observed in cytosol around vacuoles with electron microscopy.
  • Under our experimental conditions, polyP granules were not observed.
  • The method directly demonstrated the localization of polyP at the electron microscopic level for the first time and enabled the visualization of polyP localization with much higher specificity and resolution than with other conventional methods.

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  • (PMID = 16204477.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Affinity Labels; 0 / Epitopes; 0 / Polyphosphates; EC 3.6.- / Acid Anhydride Hydrolases; EC 3.6.1.11 / exopolyphosphatase
  • [Other-IDs] NLM/ PMC1266008
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31. Fenech DS, Takahashi T, Liu M, Spencer L, Swallow CJ, Cohen Z, Macrae HM, McLeod RS: Function and quality of life after transanal excision of rectal polyps and cancers. Dis Colon Rectum; 2007 May;50(5):598-603
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  • [Title] Function and quality of life after transanal excision of rectal polyps and cancers.
  • PURPOSE: The purpose of this study was to determine the functional outcomes and health-related quality of life of patients after transanal excision of rectal cancers or polyps and to assess the relationship between functional outcomes and health-related quality of life.
  • Of these, 29 had villous adenomas, 2 had carcinoids, and 1 had a hyperplastic polyp.
  • [MeSH-major] Colonic Polyps / surgery. Fecal Incontinence / physiopathology. Quality of Life. Recovery of Function. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Biopsy. Female. Humans. Male. Middle Aged. Statistics, Nonparametric. Surveys and Questionnaires. Treatment Outcome

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  • (PMID = 17309002.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Summers RM: Improving the accuracy of CTC interpretation: computer-aided detection. Gastrointest Endosc Clin N Am; 2010 Apr;20(2):245-57
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  • Computer-aided polyp detection aims to improve the accuracy of the colonography interpretation.
  • Computer-aided polyp detection has developed rapidly in the past decade in the laboratory setting and has sensitivities comparable with those of experts.
  • Computer-aided polyp detection tends to help inexperienced readers more than experienced ones and may also lead to small reductions in specificity.
  • In its currently proposed use as an adjunct to standard image interpretation, computer-aided polyp detection serves as a spellchecker rather than an efficiency enhancer.
  • [MeSH-major] Colonic Polyps / radiography. Colonography, Computed Tomographic / standards. Diagnosis, Computer-Assisted / methods

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20451814.001).
  • [ISSN] 1558-1950
  • [Journal-full-title] Gastrointestinal endoscopy clinics of North America
  • [ISO-abbreviation] Gastrointest. Endosc. Clin. N. Am.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CL040003-06
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] United States
  • [Number-of-references] 80
  • [Other-IDs] NLM/ NIHMS192941; NLM/ PMC2868270
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33. Wałega P, Scheyer M, Kenig J, Herman RM, Arnold S, Nowak M, Cegielny T: Two-center experience in the treatment of hemorrhoidal disease using Doppler-guided hemorrhoidal artery ligation: functional results after 1-year follow-up. Surg Endosc; 2008 Nov;22(11):2379-83
MedlinePlus Health Information. consumer health - Hemorrhoids.

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  • Fifty-nine patients after anorectal folds, fissure or anal canal polyp excision required analgesics for 1-2 days.

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  • (PMID = 18622559.001).
  • [ISSN] 1432-2218
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34. Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T: Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol; 2006 Oct;26(19):7211-23
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Concomitantly, epithelial cell proliferation in the polyps was significantly attenuated, suggesting that Sphk1 regulates adenoma progression.
  • Although the S1P receptors (S1P1R, S1P2R, and S1P3R) are expressed, polyp incidence or size was unaltered in Apc Min/+ S1p2r(-/-), Apc Min/+ S1p3r(-/-), and Apc Min/+ S1p1r(+/-) bigenic mice.
  • Concomitantly, epithelial cell proliferation and the expression of the G1/S cell cycle regulator CDK4 and c-myc were diminished in the polyps of Apc Min/+ Sphk1(-/-) mice.

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  • (PMID = 16980623.001).
  • [ISSN] 0270-7306
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA77528; United States / NHLBI NIH HHS / HL / HL70694; United States / NCI NIH HHS / CA / P01 CA077839; United States / NHLBI NIH HHS / HL / P01 HL070694; United States / NHLBI NIH HHS / HL / R37 HL067330; United States / NHLBI NIH HHS / HL / R01 HL067330; United States / NCI NIH HHS / CA / R01 CA077528; United States / NCI NIH HHS / CA / CA77839; United States / NHLBI NIH HHS / HL / HL67330
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Lysophospholipids; 0 / RNA, Messenger; 0 / Receptors, Lysosphingolipid; 26993-30-6 / sphingosine 1-phosphate; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / sphingosine kinase; NGZ37HRE42 / Sphingosine
  • [Other-IDs] NLM/ PMC1592880
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35. Varela C, Mauriaca C, Paradela A, Albar JP, Jerez CA, Chávez FP: New structural and functional defects in polyphosphate deficient bacteria: a cellular and proteomic study. BMC Microbiol; 2010;10:7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Inorganic polyphosphate (polyP), a polymer of tens or hundreds of phosphate residues linked by ATP-like bonds, is found in all organisms and performs a wide variety of functions.
  • PolyP is synthesized in bacterial cells by the actions of polyphosphate kinases (PPK1 and PPK2) and degraded by exopolyphosphatase (PPX).
  • Bacterial cells with polyP deficiencies due to knocking out the ppk1 gene are affected in many structural and important cellular functions such as motility, quorum sensing, biofilm formation and virulence among others.
  • By using this approach we found new structural and functional defects in the polyP-accumulating bacteria Pseudomonas sp.
  • B4, which are most likely due to differences in the polyP-removal strategy.
  • Finally, we used comparative proteomics in order to elucidate the cellular adjustments that occurred during polyP deficiency in this bacterium and found some clues that helped to understand the structural and functional defects observed.
  • CONCLUSIONS: The results obtained suggest that during polyP deficiency energy metabolism and particularly nucleoside triphosphate (NTP) formation were affected and that bacterial cells overcame this problem by increasing the flux of energy-generating metabolic pathways such as tricarboxilic acid (TCA) cycle, beta-oxidation and oxidative phosphorylation and by reducing energy-consuming ones such as active transporters and amino acid biosynthesis.
  • Furthermore, our results suggest that a general stress response also took place in the cell during polyP deficiency.

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  • (PMID = 20067623.001).
  • [ISSN] 1471-2180
  • [Journal-full-title] BMC microbiology
  • [ISO-abbreviation] BMC Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Lipopolysaccharides; 0 / Polyphosphates; 0 / Proteome; EC 2.7.4.- / Phosphotransferases (Phosphate Group Acceptor); EC 2.7.4.1 / polyphosphate kinase; EC 3.6.- / Acid Anhydride Hydrolases; EC 3.6.1.11 / exopolyphosphatase
  • [Other-IDs] NLM/ PMC2817675
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36. Belshaw NJ, Elliott GO, Foxall RJ, Dainty JR, Pal N, Coupe A, Garg D, Bradburn DM, Mathers JC, Johnson IT: Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. Br J Cancer; 2008 Jul 8;99(1):136-42
The Lens. Cited by Patents in .

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  • Quantitative methylation-specific PCR profiling applied to biopsies was used to quantify low levels of CGI methylation of 18 genes in the morphologically normal colonic mucosa of neoplasia-free subjects, adenomatous polyp patients, cancer patients and their tumours.
  • Multinomial logistic regression models based on the CGI methylation profiles from normal mucosa correctly identified 78.9% of cancer patients and 87.9% of non-cancer (neoplasia-free+polyp) patients (P=4.93 x 10(-7)) using APC, HPP1, p16, SFRP4, WIF1 and ESR1 methylation as the most informative variables.
  • Similarly, CGI methylation of SFRP4, SFRP5 and WIF1 correctly identified 61.5% of polyp patients and 78.9% of neoplasia-free subjects (P=0.0167).

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  • (PMID = 18542073.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] ENG
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2453007
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37. Zorcolo L, Fantola G, Cabras F, Marongiu L, D'Alia G, Casula G: Preoperative staging of patients with rectal tumors suitable for transanal endoscopic microsurgery (TEM): comparison of endorectal ultrasound and histopathologic findings. Surg Endosc; 2009 Jun;23(6):1384-9
MedlinePlus Health Information. consumer health - Colonoscopy.

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  • TEM was considered the treatment of choice for uT0-1/N0 lesions located between 2 and 12 cm from the anal verge.
  • Mean distance of the tumor from the anal verge was 6.6 cm (range 2-12 cm).
  • Of 54 carcinomas, 5 were pT0 because TEM was performed to remove resection margins of a malign polyp already snared.
  • CONCLUSIONS: ERUS is useful to confirm the diagnosis of adenoma and predict depth of mural invasion in early rectal cancer.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Reproducibility of Results. Retrospective Studies

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  • (PMID = 19263149.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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38. von Roon AC, Tekkis PP, Clark SK, Heriot AG, Lovegrove RE, Truvolo S, Nicholls RJ, Phillips RK: The impact of technical factors on outcome of restorative proctocolectomy for familial adenomatous polyposis. Dis Colon Rectum; 2007 Jul;50(7):952-61
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  • Primary outcomes were major complications, pouch function, and neoplastic transformation in the anal transitional zone.
  • The incidence of polyps at the anal transitional zone was lower with handsewn than with stapled anastomosis (19 vs. 38 percent; P=0.047).
  • Handsewn ileoanal anastomosis with mucosectomy seems to reduce the incidence of subsequent neoplasia in the anal transitional zone but does not eliminate the risk of cancer.


39. Karuppiah SV, Dhaliwal A, Loudon MA: Retrieval of large colonic polyps: simple use of proctoscope. J Laparoendosc Adv Surg Tech A; 2007 Dec;17(6):799-801
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • [Title] Retrieval of large colonic polyps: simple use of proctoscope.
  • Retrieval of polyps during colonoscopic procedures can be technically difficult and time consuming.
  • This is particularly the case when attempting to retrieve large polyps intact through the anal canal of an anxious patient with a hypertonic sphincter.
  • In this paper, we describe a simple technique that permits the complete removal of a large polyp intact by using a readily available theater instrument.
  • [MeSH-major] Colonic Polyps / surgery. Proctoscopes

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  • (PMID = 18158813.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Linguraru MG, Zhao S, Van Uitert RL, Liu J, Fletcher JG, Manduca A, Summers RM: CAD of colon cancer on CT colonography cases without cathartic bowel preparation. Conf Proc IEEE Eng Med Biol Soc; 2008;2008:2996-9
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  • Computer-aided diagnosis (CAD) systems must show sufficient versatility to produce robust analysis on a large variety of data.
  • This procedure introduces additional challenges for the diagnosis, such as poorly tagged stool, stool sticking to colonic walls, and heterogeneous stool (tagged stool mixed with air or untagged stool).
  • Colonoscopy data are automatically cleansed of residual stool to enhance the polyp appearance for improved diagnosis.
  • Results show stool removal accuracy on polyps which are partially or fully covered by stool.
  • The automatic detection of colon polyps using our CAD system on cathartic-free data improves considerably with the addition of the automatic stool removal module from 74% to 86% true positive (TP) rate at 6.4 false positives (FP)/case.
  • [MeSH-major] Colon / diagnostic imaging. Colon / pathology. Colonography, Computed Tomographic / methods. Diagnosis, Computer-Assisted / methods. Pattern Recognition, Automated / methods

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  • (PMID = 19163336.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CL999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Laxatives
  • [Other-IDs] NLM/ NIHMS69939; NLM/ PMC2630581
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41. Smith D, Ballal M, Hodder R, Selvachandran SN, Cade D: The adenoma carcinoma sequence: an indoctrinated model for tumorigenesis, but is it always a clinical reality? Colorectal Dis; 2006 May;8(4):296-301
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • Neoplastic lesions were either biopsied or removed after noting distance from the anal margin.
  • RESULTS: Of 4089 patients, polyps were identified in 8.0% and cancer in 4.2%.
  • Polyp behaviour along with malignant propensity may actually be site dependent, with rectal polyps harbouring a more aggressive phenotype.
  • [MeSH-major] Adenoma / pathology. Carcinoma / pathology. Colonic Neoplasms / pathology. Colonic Polyps / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16630233.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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42. Røkke O, Iversen KB, Ovrebø K, Maartmann-Moe H, Skarstein A, Halvorsen JF: Local resection of rectal tumors by transanal endoscopic microsurgery: experience with the first 70 cases. Dig Surg; 2005;22(3):182-9; discussion 189-90
MedlinePlus Health Information. consumer health - Carcinoid Tumors.

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  • BACKGROUND: Transanal endoscopic microsurgery (TEM) can access the whole rectum up to 20 cm from the anal verge.
  • RESULTS: TEM was performed in 37 men and 33 women, median age 70.5 (19-90) years, for anticipated adenoma (n = 64), adenocarcinoma (n = 3), rectal ulcer (n = 1), and re-resection after snare resection of rectal polyp with adenocarcinoma (n = 1) and carcinoid tumor (n = 1).
  • The distance from the anal verge to the lower tumor border was 5.5 (2.5-14) cm.

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16137996.001).
  • [ISSN] 0253-4886
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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43. Näppi J, Yoshida H: Adaptive correction of the pseudo-enhancement of CT attenuation for fecal-tagging CT colonography. Med Image Anal; 2008 Aug;12(4):413-26
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  • The effect of ADC on ftCTC was assessed visually and quantitatively by comparison of the accuracy of computer-aided detection (CAD) without and with the use of the ADC method in two different types of clinical ftCTC databases: 20 laxative ftCTC cases with 24 polyps, and 23 reduced-preparation ftCTC cases with 28 polyps.
  • With ADC, the free-response receiver operating characteristic curves indicating CAD performance in polyp detection yielded normalized partial area-under-curve values of 0.91 and 0.80 for the two databases, respectively, with statistically significant improvement over conventional thresholding-based approaches (p<0.05).

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  • (PMID = 18313349.001).
  • [ISSN] 1361-8423
  • [Journal-full-title] Medical image analysis
  • [ISO-abbreviation] Med Image Anal
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA095279-06; United States / NCI NIH HHS / CA / R01 CA095279-06; United States / NCI NIH HHS / CA / R01 CA095279-05; United States / NCI NIH HHS / CA / CA095279-04; United States / NCI NIH HHS / CA / R56 CA095279; United States / NCI NIH HHS / CA / CA095279-05; United States / NCI NIH HHS / CA / R01 CA095279-04; United States / NCI NIH HHS / CA / R01 CA131718; United States / NCI NIH HHS / CA / CA095279; United States / NCI NIH HHS / CA / R01 CA095279
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ NIHMS62173; NLM/ PMC2762861
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44. Floyd ND, Saclarides TJ: Transanal endoscopic microsurgical resection of pT1 rectal tumors. Dis Colon Rectum; 2006 Feb;49(2):164-8
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  • Patient age, gender, tumor distance from the anal verge, lesion size, operative time, blood loss, complications, recurrence, and survival rates were prospectively recorded.
  • Average tumor distance from the anal verge was 7 (range, 0-13) cm; average size was 2.4 (range, 1-10) cm.
  • Sixteen patients had pT1 lesions removed piecemeal during colonoscopy; there was no residual tumor after transanal endoscopic microsurgical resection of the polyp site.

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  • (PMID = 16362801.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Zhu H, Liang Z, Pickhardt PJ, Barish MA, You J, Fan Y, Lu H, Posniak EJ, Richards RJ, Cohen HL: Increasing computer-aided detection specificity by projection features for CT colonography. Med Phys; 2010 Apr;37(4):1468-81
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  • This study aims to develop projection-based features which characterize true and false positives to increase the specificity while maintaining high sensitivity in detecting colonic polyps.
  • METHODS: In this study, two-dimensional projection images are obtained from each initial polyp candidate or volume of interest, and features are extracted from both the gray and color projection images to differentiate FPs from true positives.
  • These projection features were tested to exclude different types of FPs, such as haustral folds, rectal tubes, and residue stool using a database of 325 patient studies (from two different institutions), which includes 556 scans at supine and/or prone positions with 347 polyps and masses sized from 5 to 60 mm.
  • The experimental evaluation was conducted for large polyps (> or = 10 mm) and medium-sized polyps (5-9 mm) separately.
  • RESULTS: For large polyps, the additional usage of the projection features reduces the FP rate from 5.31 to 1.92 per scan at the comparable by-polyp sensitivity level of 93.1%.
  • For medium-sized polyps, the FP rate is reduced from 8.89 to 5.23 at the sensitivity level of 80.6%.
  • The percentages of FP reduction are 63.9% and 41.2% for the large and medium-sized polyps, respectively, without sacrificing detection sensitivity.
  • CAD of colonic polyps is supposed to help radiologists to improve their performance in interpreting computed tomographic colonography images.
  • [MeSH-major] Colonic Polyps / diagnostic imaging. Colonography, Computed Tomographic / methods. Diagnosis, Computer-Assisted / methods

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  • (PMID = 20443468.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA082402; United States / NCI NIH HHS / CA / R21 CA120917; United States / NCI NIH HHS / CA / CA120917; United States / NCI NIH HHS / CA / CA082402; United States / NCI NIH HHS / CA / R33 CA120917
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2848845
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46. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM: Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol; 2006 Aug;4(8):1035-8
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  • BACKGROUND & AIMS: Familialadenomatous polyposis (FAP) is an autosomal-dominant disorder characterized by the development of hundreds of colorectal adenomas and eventual colorectal cancer.
  • METHODS: Five FAP patients with prior colectomy (4 with retained rectum and 1 with an ileal anal pouch) received curcumin 480 mg and quercetin 20 mg orally 3 times a day.
  • The number and size of polyps were assessed at baseline and after therapy.
  • The Wilcoxon signed-rank test was used to determine differences in the number and size of polyps.
  • RESULTS: All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin.
  • The mean percent decrease in the number and size of polyps from baseline was 60.4% (P < .05) and 50.9% (P < .05), respectively.

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  • (PMID = 16757216.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 53801; United States / NCI NIH HHS / CA / K07 CA092445; United States / NCI NIH HHS / CA / P50 CA 62924-10
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antioxidants; 9IKM0I5T1E / Quercetin; IT942ZTH98 / Curcumin
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47. Zhang S, Gao F, Chen LS, Tang ZJ, Liang JL, Wu Q: [Clinical analysis of anorectal malignant melanoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2005 Jul;8(4):309-11
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  • The onset of symptom was hematochezia, then anus prolapses.
  • 94.7% of patients had AMM within 5 cm from anus margin; the average tumor size was (3.3+/- 2.1) cm.
  • The polyp and ulcer were most common types.
  • Mile's operation was performed in most of patients (63%), while anal resection was performed in 30% of the patients.
  • [MeSH-major] Anus Neoplasms / pathology. Melanoma / pathology. Rectal Neoplasms / pathology

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  • (PMID = 16167248.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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48. Lindner SN, Knebel S, Wesseling H, Schoberth SM, Wendisch VF: Exopolyphosphatases PPX1 and PPX2 from Corynebacterium glutamicum. Appl Environ Microbiol; 2009 May;75(10):3161-70
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  • Corynebacterium glutamicum accumulates up to 300 mM of inorganic polyphosphate (PolyP) in the cytosol or in granules.
  • In comparison to that in the wild type, more intracellular PolyP accumulated in the Deltappx1 and Deltappx2 deletion mutations but less when either ppx1 or ppx2 was overexpressed.
  • Growth experiments, exopolyphosphatase activities, and intracellular PolyP concentrations revealed PPX2 as being a major exopolyphosphatase from C. glutamicum.

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  • (PMID = 19304823.001).
  • [ISSN] 1098-5336
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Enzyme Activators; 0 / Polyphosphates; 42Z2K6ZL8P / Manganese; EC 3.6.- / Acid Anhydride Hydrolases; EC 3.6.1.11 / exopolyphosphatase; I38ZP9992A / Magnesium; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ PMC2681651
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49. Wegdam JA, Hofker HS, Dijkstra G, Stolk MF, Jacobs MA, Suurmeijer AJ: [Occult gastrointestinal bleeding due to a Dieulafoy lesion in the terminal ileum]. Ned Tijdschr Geneeskd; 2006 Aug 12;150(32):1776-9
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  • After multiple oesophagogastroduodenoscopies and colonoscopies, videocapsule endoscopy finally demonstrated a polyp-like lesion in the terminal ileum.
  • The lesion had not been detected despite two attempts (oral and anal) at double-balloon enteroscopy and even a peroperative enteroscopy.
  • [MeSH-major] Endoscopes, Gastrointestinal. Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / diagnosis. Ileum / pathology
  • [MeSH-minor] Anemia, Iron-Deficiency / etiology. Diagnosis, Differential. Humans. Male. Middle Aged. Video Recording

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  • (PMID = 16948240.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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50. Näppi J, Yoshida H: Virtual tagging for laxative-free CT colonography: pilot evaluation. Med Phys; 2009 May;36(5):1830-8
MedlinePlus Health Information. consumer health - Colonic Polyps.

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  • The effect of virtual tagging was evaluated by comparing the detection accuracy of a fully automated polyp detection scheme without and with the method.
  • [MeSH-major] Artifacts. Artificial Intelligence. Colonic Polyps / diagnostic imaging. Colonography, Computed Tomographic / methods. Pattern Recognition, Automated / methods. Radiographic Image Enhancement / methods. Radiographic Image Interpretation, Computer-Assisted / methods

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  • (PMID = 19544802.001).
  • [ISSN] 0094-2405
  • [Journal-full-title] Medical physics
  • [ISO-abbreviation] Med Phys
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA095279; United States / NCI NIH HHS / CA / R56 CA095279; United States / NCI NIH HHS / CA / CA095279
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Laxatives
  • [Other-IDs] NLM/ PMC2736708
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51. Hsu CH, Long Q, Alberts DS: Estimation of colorectal adenoma recurrence with dependent censoring. BMC Med Res Methodol; 2009 Sep 29;9:66
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  • BACKGROUND: Due to early colonoscopy for some participants, interval-censored observations can be introduced into the data of a colorectal polyp prevention trial.
  • The method described here is explored by simulation and illustrated with an example from a colorectal polyp prevention trial.
  • RESULTS: We first show that midpoint imputation under an assumption of independent censoring will produce an unbiased estimate of recurrence rate at the end of the trial, which is often the main interest of a colorectal polyp prevention trial, and then show in simulations that the weighted Kaplan-Meier method using the information from auxiliary variables based on the midpoint imputed data can improve efficiency in a situation with independent censoring and reduce bias in a situation with dependent censoring compared to the conventional methods, while estimating the recurrence rate at the end of the trial.

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  • (PMID = 19788750.001).
  • [ISSN] 1471-2288
  • [Journal-full-title] BMC medical research methodology
  • [ISO-abbreviation] BMC Med Res Methodol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA130089; United States / NCI NIH HHS / CA / P01 CA41108; United States / NCI NIH HHS / CA / P30 CA23074; United States / NCI NIH HHS / CA / R03 CA130089-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2760573
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52. Rao VS, Ahmad N, Al-Mukhtar A, Stojkovic S, Moore PJ, Ahmad SM: Comparison of rigid vs flexible sigmoidoscopy in detection of significant anorectal lesions. Colorectal Dis; 2005 Jan;7(1):61-4
MedlinePlus Health Information. consumer health - Rectal Disorders.

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  • Of the 115 (75.6%) declared normal by RS, 39 (33.9%) had significant lesions including 7 polyps and 4 malignant lesions within 20 cm of the anal verge during FS.
  • Of the 31 patients (20.4%) in whom RS was not helpful due to faecal loading, 15 (48.4%) had significant lesions including 4 malignancies and 1 polyp --all within 20 cm of the anal verge during FS.
  • Only 2 polyps and 1 malignant lesion were picked up by both flexible and rigid sigmoidoscopy.

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  • (PMID = 15606587.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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53. Barreda B F, Combe G J, Valdez P LA, Sánchez L J: [Clinical aspects in polyps of the colon]. Rev Gastroenterol Peru; 2007 Apr-Jun;27(2):131-47
MedlinePlus Health Information. consumer health - Colonic Polyps.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical aspects in polyps of the colon].
  • INTRODUCTION: The colonics polyps according to their number, size, location, age of presentation and mainly, according to their histology, have the potentiality of malignant degeneration, which makes of a continuous study and pursuit susceptible.
  • OBJECTIVES: To evaluate the relation between the histologic type of the colon polyps, its location, the degree of dysplasia, the size, its possible commitment by carcinoma, the age, sex and the handling that has occurred them, in a series of 684 patients of the National Institute of Enfermedades Neoplásicas (INEN) between the 1 of January from 1974 to the 31 of March of the 2004.
  • MATERIAL AND METHODS: The revision of clinical histories of 840 patients with the diagnosis of colon polyp was made who attended the service of Gastroenterology of the INEN between the 1 of January from 1974 to the 31 of March of 2004 and a card predesigned for each clinical history filled.
  • 1162 resecteds polyps evaluated themselves in this period.
  • 156 patients by diagnosis related to cancer and familiar adenomatouspoliposis did not include themselves.
  • The final sample was of 684 patients, in whom it was 1057 polyps.
  • Other endoscopic findings were: internal hemorrhoids (172), colonic diverticulosis (50), anal fissure (4), and nonspecific ulcerative colitis (2).
  • RESULTS: 1057 polyps extirpated, by means of the endoscopy polipectomy were 1016, with colectomy were 32 and with transanal resection without colectomy they 9.
  • Within the histology of the 1057 polyps, 331 was briefed (31.3%) that were hyperplasic, 448 (42.4%) adenomas, 278 (26.3%) others and 35 (8.2%) adenocarcinomas on adenomas.
  • Adenocarcinoma (carcinomas on adenomas), was present mainly in polyps villous type, with dysplasia severe and greater to 10 mm.
  • Nevertheless, in smaller polyps of 5mm with dysplasia severe, was a polyp invaded by cancer, that represents the 0,8% of millimetric polyps.
  • The made handling was mainly endoscopic, with 96% of the resected polyps this way, also slogan transanal resection and segmental colonic resection.
  • The colectomy was necessary in 3% of all the made interventions, dysplasia severe or carcinoma was made in adenomatous polyps with, and in greater percentage in greater polyps of 20 mm (53%).
  • On the other hand, in polyps with level of invasion Haggitt 3 and 4, the colectomy was the election treatment.
  • CONCLUSIONS: The Evaluation of colonic polyps in INEN is predominantly by endoscopy.
  • The polyps are more frequent over the 50 years and have preferred location in the left colon.
  • All polyps, from the millimetric ones, including the hyperplasic, must be considered marks of neoplasia and extirpated in its totality.
  • [MeSH-major] Colonic Polyps / pathology. Colonic Polyps / surgery

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  • (PMID = 17712391.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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54. Werner TP, Amrhein N, Freimoser FM: Inorganic polyphosphate occurs in the cell wall of Chlamydomonas reinhardtii and accumulates during cytokinesis. BMC Plant Biol; 2007;7:51

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  • PolyP has also been found in fungal cell walls and bacterial envelopes, but has so far not been measured directly or stained specifically in the cell wall of any plant or alga.

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  • [Chemical-registry-number] 0 / Polyphosphates; EC 3.6.- / Acid Anhydride Hydrolases; EC 3.6.1.11 / exopolyphosphatase
  • [Other-IDs] NLM/ PMC2096623
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55. Tobin KM, McGrath JW, Mullan A, Quinn JP, O'Connor KE: Polyphosphate accumulation by Pseudomonas putida CA-3 and other medium-chain-length polyhydroxyalkanoate-accumulating bacteria under aerobic growth conditions. Appl Environ Microbiol; 2007 Feb;73(4):1383-7
The Lens. Cited by Patents in .

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  • Pseudomonas putida CA-3 accumulates polyphosphate (polyP) and medium-chain-length polyhydroxyalkanoate (mclPHA) concurrently under nitrogen limitation.
  • Five other mclPHA-accumulating Pseudomonas strains are capable of simultaneous polyP and mclPHA biosynthesis.
  • It appears that polyP is not the rate-limiting step for mclPHA accumulation in these Pseudomonas strains.

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  • (PMID = 17158616.001).
  • [ISSN] 0099-2240
  • [Journal-full-title] Applied and environmental microbiology
  • [ISO-abbreviation] Appl. Environ. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polyphosphates; EC 2.3.- / Acyltransferases; EC 2.3.1.- / poly(3-hydroxyalkanoic acid) synthase
  • [Other-IDs] NLM/ PMC1828677
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56. Stumpf JD, Foster PL: Polyphosphate kinase regulates error-prone replication by DNA polymerase IV in Escherichia coli. Mol Microbiol; 2005 Aug;57(3):751-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The ppk gene encodes polyphosphate kinase (Ppk), an enzyme that catalyses the polymerization of inorganic phosphate into long chains of polyphosphate (polyP).
  • Adaptive mutation is inhibited both by the absence of Ppk, which results in low amounts of polyP, and by overproduction of Ppk, which results in high amounts of polyP, suggesting that an optimal level of polyP is necessary.
  • Taken together, these results suggest a novel mechanism involving polyP that directly or indirectly regulates DNA polymerase activity or fidelity.

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  • (PMID = 16045619.001).
  • [ISSN] 0950-382X
  • [Journal-full-title] Molecular microbiology
  • [ISO-abbreviation] Mol. Microbiol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM065175; United States / NIGMS NIH HHS / GM / GM651575; United States / PHS HHS / / T32 G07757
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DinB protein, E coli; 0 / Escherichia coli Proteins; EC 2.7.4.- / Phosphotransferases (Phosphate Group Acceptor); EC 2.7.4.1 / polyphosphate kinase
  • [Other-IDs] NLM/ NIHMS5039; NLM/ PMC1314974
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57. Nocek B, Kochinyan S, Proudfoot M, Brown G, Evdokimova E, Osipiuk J, Edwards AM, Savchenko A, Joachimiak A, Yakunin AF: Polyphosphate-dependent synthesis of ATP and ADP by the family-2 polyphosphate kinases in bacteria. Proc Natl Acad Sci U S A; 2008 Nov 18;105(46):17730-5
Hazardous Substances Data Bank. (L)-ALANINE .

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  • Inorganic polyphosphate (polyP) is a linear polymer of tens or hundreds of phosphate residues linked by high-energy bonds.
  • This ubiquitous and abundant biopolymer plays numerous and vital roles in metabolism and regulation in prokaryotes and eukaryotes, but the underlying molecular mechanisms for most activities of polyP remain unknown.
  • In prokaryotes, the synthesis and utilization of polyP are catalyzed by 2 families of polyP kinases, PPK1 and PPK2, and polyphosphatases.
  • Proteins with a single PPK2 domain catalyze polyP-dependent phosphorylation of ADP to ATP, whereas proteins containing 2 fused PPK2 domains phosphorylate AMP to ADP.
  • Thus, the PPK2s represent a molecular mechanism, which potentially allow bacteria to use polyP as an intracellular energy reserve for the generation of ATP and survival.

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  • (PMID = 19001261.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Databank-accession-numbers] PDB/ 3CZP/ 3CZQ
  • [Grant] United States / NIGMS NIH HHS / GM / GM074942-04S2; United States / NIGMS NIH HHS / GM / U54 GM074942; United States / NIGMS NIH HHS / GM / GM074942; United States / NIGMS NIH HHS / GM / U54 GM074942-04S2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polyphosphates; 61D2G4IYVH / Adenosine Diphosphate; 8L70Q75FXE / Adenosine Triphosphate; EC 2.7.4.- / Phosphotransferases (Phosphate Group Acceptor); EC 2.7.4.1 / polyphosphate kinase; OF5P57N2ZX / Alanine
  • [Other-IDs] NLM/ PMC2584756
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58. Zakharash MP, Poĭda OI: [Application of preparations relief ultra and relief advance in practice of coloproctological department]. Klin Khir; 2005 Oct;(10):9-12
Hazardous Substances Data Bank. ZINC SULFATE .

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  • Efficacy of application of preparations Relief Ultra and Relief Advance as pathogenetically directed medicines was established, basing on analysis of the examination and treatment results in 133 patients with anal region diseases (acute and chronic hemorrhoids, nonspeciphic ulcerative colitis, the Crohn's disease, acute paraproctitis, rectal polyp).
  • Application of preparation Relief Ultra endorectally in conjunction with preparation Relief Advance endorectally and locally on the wound surface is indicated after performance of elective and urgent operative interventions for rectal and anal zone diseases.

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  • (PMID = 16509076.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] UKR
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Fish Oils; 0 / Suppositories; 3X7931PO74 / hydrocortisone acetate; 7733-02-0 / Zinc Sulfate; WI4X0X7BPJ / Hydrocortisone
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59. Whittle DO, Lee MG, Hanchard B: Juvenile polyposis syndrome. West Indian Med J; 2010 Jun;59(3):306-8
Genetic Alliance. consumer health - Juvenile polyposis syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Juvenile polyposis syndrome (JPS) is rare and is present when there are multiple juvenile polyps in the gastrointestinal tract, usually the colon.
  • We report the case of a 21-year old male with a two-year history of intermittent rectal bleeding and anal protrusion.
  • Colonoscopy revealed multiple pedunculated cherry red polyps mainly in the left colon.
  • Histology confirmed juvenile polyps.
  • It is important to distinguish between patients with JPS and patients with an isolated harmatomatous juvenile polyp.

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  • (PMID = 21291112.001).
  • [ISSN] 0043-3144
  • [Journal-full-title] The West Indian medical journal
  • [ISO-abbreviation] West Indian Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Jamaica
  • [Chemical-registry-number] Juvenile polyposis syndrome
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60. Park KJ, Choi HJ, Kim SH, Han SY, Hong SH, Cho JH, Kim HH: Sigmoidorectal intussusception of adenoma of sigmoid colon treated by laparoscopic anterior resection after sponge-on-the-stick-assisted manual reduction. World J Gastroenterol; 2006 Jan 7;12(1):146-9
MedlinePlus Health Information. consumer health - Rectal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present herein a case report of sigmoidorectal intussusception as an unusual case of sigmoid adenomatous polyp.
  • He initially visited his general practitioner and was diagnosed as having an intraluminal mass of 15 cm from the anal verge.
  • Gastrograffin enema showed that the invaginated bowel segment was 3 cm from the anal verge.

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  • (PMID = 16440436.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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61. Hyodo H, Tomita Y, Hirai K, Hirakawa H, Ueno S, Ishiguro H: Turner syndrome with ulcerative colitis. Clin Pediatr Endocrinol; 2009 Oct;18(4):101-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Flexible sigmoidoscopy showed that the mucosa was erythematous and friable upon touch and that the wall had frank hemorrhage and inflammatory polyp formation from the anal verge through the splenic flexure.

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  • (PMID = 23926368.001).
  • [ISSN] 0918-5739
  • [Journal-full-title] Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
  • [ISO-abbreviation] Clin Pediatr Endocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC3687612
  • [Keywords] NOTNLM ; 46,X,i(Xq) / Turner syndrome / ulcerative colitis
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62. Kuhne HP, Göller T, Schneider I, Bozkurt T, Becker HP: [Unclear per anum bleeding during pregnancy]. Chirurg; 2005 Aug;76(8):765-8
MedlinePlus Health Information. consumer health - Tumors and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rectoscopy showed the cause to be a polyp the size of a fingertip 9 cm from the anus.
  • About 1 year later, the same patient experienced sharp pains and anal bleeding during defecation.
  • [MeSH-major] Intestinal Polyps / diagnosis. Melena / etiology. Neuroendocrine Tumors / diagnosis. Pregnancy Complications / etiology. Pregnancy Complications, Neoplastic / diagnosis. Puerperal Disorders / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Disease Progression. Female. Humans. Infant, Newborn. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Staging. Pregnancy. Rectum / pathology. Rectum / surgery

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  • (PMID = 15971036.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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63. Nikpour S, Ali Asgari A: Colonoscopic evaluation of minimal rectal bleeding in average-risk patients for colorectal cancer. World J Gastroenterol; 2008 Nov 14;14(42):6536-40
MedlinePlus Health Information. consumer health - Colorectal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neoplastic polyps, colorectal carcinoma, and IBD were defined as significant lesions.
  • Hemorrhoids (54.2%), anal fissures (14.2%) and ulcerative colitis (14.2%) were the most common lesions and colonoscopy was normal in 8.0%.
  • Significant lesions were found in 121 (30.1%) patients, including 26 patients (6.5%) with adenocarcinoma and 30 (7.5%) with adenomatous polyps.
  • Almost all patients with significant lesions had at least one lesion in the distal colon; an adenocarcinoma and an adenomatous polyp in the proximal colon were found in 2 patients with hemorrhoids.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenomatous Polyps / diagnosis. Colonic Polyps / diagnosis. Colonoscopy. Colorectal Neoplasms / diagnosis. Hemorrhage / etiology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Colitis, Ulcerative / complications. Colitis, Ulcerative / diagnosis. Female. Fissure in Ano / complications. Fissure in Ano / diagnosis. Hemorrhoids / complications. Hemorrhoids / diagnosis. Humans. Male. Middle Aged. Patient Selection. Predictive Value of Tests. Prevalence. Prospective Studies. Rectum. Risk Assessment. Sigmoidoscopy. Young Adult


64. Plum N, May AD, Manner H, Ell C: [Peutz-Jeghers syndrome: endoscopic detection and treatment of small bowel polyps by double-balloon enteroscopy]. Z Gastroenterol; 2007 Oct;45(10):1049-55
Genetic Alliance. consumer health - Peutz Jeghers syndrome.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Peutz-Jeghers syndrome: endoscopic detection and treatment of small bowel polyps by double-balloon enteroscopy].
  • INTRODUCTION: Peutz-Jeghers syndrome (PJS) is characterised by a combination of hamartomatous gastrointestinal polyps and mucocutaneous melanin pigmentation.
  • The polyps occur mainly in the small bowel and can lead to intestinal obstruction, intussusception and bleeding.
  • Until only a few years ago, primary surgical resection and intraoperative endoscopy and polypectomy were the only available means of treating polyps in the mid-small bowel in these patients.
  • The size, number and location of the diagnosed and endoscopically resected small-bowel polyps were documented as were all complications associated with the examination or treatment.
  • RESULTS: A total of 47 DBE-procedures were performed (oral approach 39, anal approach 8).
  • The examinations revealed a total of 178 polyps.
  • 47 polyps were removed by endoscopic polypectomy on the grounds of their size and/or gross appearance.
  • The largest small-bowel polyp resected was 50 mm (min.
  • CONCLUSION: DBE is a safe and reliable procedure for the diagnosis of small-bowel polyps in patients with PJS.
  • In addition to macroscopic assessment and biopsy of suspicious areas, it permits the exact localisation as well as preoperative marking of polyps that are primary candidates for surgery.
  • DBE revolutionises the therapeutic options for polyps in the region of the mid-small bowel and limits the indications for primary surgical management.
  • [MeSH-major] Endoscopy, Gastrointestinal / methods. Intestinal Polyps / pathology. Intestinal Polyps / surgery. Intestine, Small / pathology. Intestine, Small / surgery

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  • (PMID = 17924301.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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65. Rousková B, Kuklová P, Skába R, Frantlová M: [Rates and histological characteristics of rectal polyps in childhood]. Rozhl Chir; 2006 Oct;85(10):501-3
MedlinePlus Health Information. consumer health - Rectal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Rates and histological characteristics of rectal polyps in childhood].
  • AIM OF STUDY: To determine a single centre incidence, rate of early and late complications and sequelae and histological characteristics of solitary rectosigmoideal polyps in children.
  • METHODS: Retrospective analysis of hospital charts and histological characteristics of patients operated for rectosigmoideal polyps between January 1995 and December 2005.
  • The presenting symptom was bleeding in 14 pts, anal prolaps once and combination of both symptoms 5 times.
  • The polyps were localized 3-15 cm from anocutaneous border, on the posterior intestinal wall.
  • Histological examination showed a juvenile polyp in 15 (75%) patients, atypical juvenile polyp and inflammatory polyp in 2 patients each and lymphoid polyp in one case.
  • CONCLUSION: Polyps in children are rare, surgical removal of polyps is a relatively easy operation with minimum complications.
  • [MeSH-major] Intestinal Polyps. Rectal Diseases

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  • (PMID = 17233176.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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66. Hakeem A, Badrinath K: "Scoping-around" a sigmoidorectal intussusception: a pitfall of flexible sigmoidoscopy. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An urgent flexible sigmoidoscopy (FS) showed an abnormal lesion within the anal canal and biopsy showed tubulovillous adenoma with low-grade dysplasia.
  • The intussusception was irreducible with rigid sigmoidocopy and therefore the patient underwent sigmoid resection and Hartmann's procedure, which showed a distal sigmoid polyp as a lead point for the intussusception.
  • Retrospectively looking into the case, the intussusception was present during FS, but was scoped-around and therefore lesion was considered to be in the anal canal.

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  • (PMID = 21686998.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029465
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67. Bataille D, Donner C, Cassart M, Pardou A, Nagy N, Van Hoorde E, Lingier P: Perineal lipoma in a newborn boy--a case report. Eur J Pediatr Surg; 2007 Apr;17(2):136-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report the case of a newborn presenting with a pediculated mass arising from the anal margin.
  • Sacrococcygeal teratoma, an enterogenous cyst, a polyp, a prolapse or other perineal tumors were all proposed as possible entities.
  • At birth, no other anatomic anomaly than this homogenous 2 cm para-anal lesion was seen.
  • [MeSH-major] Lipoma / congenital. Lipoma / diagnosis

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  • (PMID = 17503310.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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68. Fratesi L, Alhusayen R, Walker J: Case report of primary rectal melanoma and review of the etiology of melanoma. J Cutan Med Surg; 2008 May-Jun;12(3):117-20
MedlinePlus Health Information. consumer health - Melanoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is defined as melanoma arising in the rectal mucosa, more than 4 cm from the anal verge.
  • A polyp was removed from the low-lying rectum during colonoscopy.
  • [MeSH-major] Melanoma / diagnosis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Colonoscopy. Diagnosis, Differential. Female. Humans. Immunohistochemistry

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  • (PMID = 18544294.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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69. Strijbos SA, Hueting WE, Schipper ME, Oostvogel HJ, van Vroonhoven TJ, Gooszen HG, van Laarhoven CJ: The ileo neo rectal anastomosis (INRA) in patients with familial adenomatous polyposis: clinical results at two years. Colorectal Dis; 2005 Jul;7(4):354-9
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aims of the present study were to evaluate the function of the neorectum, to assess the morbidity and complications of the operation and to determine the incidence of neorectal polyps.
  • The anal sphincter complex was assessed by manometry and ultrasound examination.
  • Endoscopic examination showed normal mucosa and no evidence of polyp formation in all patients.
  • At a minimum follow up period of two years, no growth of polyps in the neorectum occurred.

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  • (PMID = 15932558.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Jagannathan V, Kaur P, Datta S: Polyphosphate kinase from M. tuberculosis: an interconnect between the genetic and biochemical role. PLoS One; 2010;5(12):e14336
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The enzyme Polyphosphate Kinase (PPK) catalyses the reversible transfer of the terminal γ-Pi of ATP to form a long chain Polyphosphate (PolyP).

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 21179463.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 15XUH0X66N / Tolonium Chloride; 61D2G4IYVH / Adenosine Diphosphate; 8L70Q75FXE / Adenosine Triphosphate; EC 2.7.4.- / Phosphotransferases (Phosphate Group Acceptor); EC 2.7.4.1 / polyphosphate kinase
  • [Other-IDs] NLM/ PMC3002279
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71. Mönkemüller K, Fry LC, Neumann H, Rickes S, Malfertheiner P: [Diagnostic and therapeutic utility of double balloon endoscopy: experience with 225 procedures]. Acta Gastroenterol Latinoam; 2007 Dec;37(4):216-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: 225 DBE in 178 patients, (95 males, 83 females; mean age 59 years-old, range 12-93); oral route (n=160), anal (n=65).
  • Indications (one or more per patient): GI bleeding (n=83), suspected Crohn's disease or evaluation of small bowel involvement or complications (n=35), diarrhea or malabsorption or suspected celiac disease (n=11), polyp removal in Peutz-Jeghers' syndrome or familial polyposis (n=23), tumor surveillance or search of primary tumor (n=14), abdominal pain (n=6) and miscellaneous (n=6).
  • The mean depth of insertion via the oral route was 240 cm (range 20 cm to 650 cm) and via the anal route it was 65 cm (range 10 cm a 150 cm).
  • A new diagnosis was reached in 108/178 patients (60%).
  • Findings included: angiodysplasia, ulcerations, stenosis, polyps, portal jejunopathy, ischemic jejunitis and normal.
  • CONCLUSIONS: DBE was clinically useful for reaching a new diagnosis and to start new therapies, change existing therapies, and perform an operative intervention or to provide therapeutic endoscopy in two-thirds of the investigated patients.
  • DBE is a useful and safe method to obtain tissue for diagnosis, to provide hemostasis and to perform polypectomy.
  • [MeSH-major] Catheterization / methods. Endoscopy, Gastrointestinal / methods. Intestinal Diseases / diagnosis

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  • [CommentIn] Acta Gastroenterol Latinoam. 2007 Dec;37(4):204, 271 [18254254.001]
  • (PMID = 18254259.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Argentina
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72. Mönkemüller K, Weigt J, Treiber G, Kolfenbach S, Kahl S, Röcken C, Ebert M, Fry LC, Malfertheiner P: Diagnostic and therapeutic impact of double-balloon enteroscopy. Endoscopy; 2006 Jan;38(1):67-72
MedlinePlus Health Information. consumer health - Gastrointestinal Bleeding.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Seventy DBE procedures were carried out in 53 patients (34 men, 19 women; mean age 60 years, range 24 - 80) by the oral route in 46 cases and the anal route in 24.
  • The indications for the examination were gastrointestinal bleeding (n = 29), suspected Crohn's disease (n = 6), abdominal pain (n = 4), polyp removal or evaluation in polyposis syndromes (n = 6), chronic diarrhea (n = 4), and surveillance or tumor search (n = 4).
  • A new diagnosis was obtained in 26 of the 53 patients (49 %).
  • The findings in the 70 procedures were angiodysplasia (n = 13), ulcerations or erosions (n = 5), jejunitis or ileitis (n = 5), tumors (n = 5), stenosis (n = 4), polyps (n = 5), lymphangiectasias (n = 4), Crohn's disease (n = 4), and normal (n = 17).
  • CONCLUSION: In almost two-thirds of the patients examined, DBE was clinically useful for obtaining a new diagnosis and starting new treatments, changing existing treatments, carrying out surgical intervention, or providing therapeutic endoscopy.
  • DBE is a useful and safe method of obtaining tissue for diagnosis, providing hemostasis, and carrying out polypectomy.
  • [MeSH-major] Crohn Disease / diagnosis. Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / diagnosis. Intestinal Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Angiodysplasia / diagnosis. Colonic Polyps / diagnosis. Female. Hemostasis, Surgical. Humans. Male. Middle Aged

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  • [CommentIn] Gastroenterology. 2006 Sep;131(3):969-71 [16952572.001]
  • (PMID = 16429357.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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73. Bouasker I, Khalfallah M, El Ouaer MA, Smaali I, Hani MA, Dziri C: Giant inflammatory fibrous polyp of the anal verge. Tunis Med; 2010 Jun;88(6):449-50
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant inflammatory fibrous polyp of the anal verge.
  • [MeSH-major] Anus Neoplasms / pathology. Polyps / pathology

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  • (PMID = 20517861.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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74. Leung KK, Yusuf TE: External polypectomy of a large anal canal polyp. Gastrointest Endosc; 2007 Sep;66(3):603; discussion 604
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] External polypectomy of a large anal canal polyp.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anus Neoplasms / surgery. Intestinal Polyps / surgery. Rectal Neoplasms / surgery

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  • (PMID = 17681501.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Pusiol T, Zorzi MG, Piscioli I: Coexistence of bladder prostatic-type polyp and urothelial papilloma. Anal Quant Cytol Histol; 2010 Oct;32(5):299-300
MedlinePlus Health Information. consumer health - Bladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of bladder prostatic-type polyp and urothelial papilloma.

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  • (PMID = 22043507.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Letter
  • [Publication-country] United States
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76. Thomas C, Mourra N: [Giant fibroepithelial polyp of the anus]. Gastroenterol Clin Biol; 2009 Oct-Nov;33(10-11):1024-6
MedlinePlus Health Information. consumer health - Anal Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant fibroepithelial polyp of the anus].
  • [Transliterated title] Polype fibroépithélial géant de l'anus: à propos d'un cas.
  • [MeSH-major] Anus Diseases / pathology. Intestinal Mucosa / pathology. Intestinal Polyps / pathology

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  • (PMID = 19773139.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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