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1
anal neoplasms 2005:2010[pubdate] *count=100
5761 results
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Items 1 to 100 of about 5761
1.
Mourton SM, Temple LK, Abu-Rustum NR, Gemignani ML, Sonoda Y, Bochner BH, Barakat RR, Chi DS:
Morbidity of rectosigmoid resection and primary anastomosis in patients undergoing primary cytoreductive surgery for advanced epithelial ovarian cancer.
Gynecol Oncol
; 2005 Dec;99(3):608-14
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OBJECTIVES: Studies from the colorectal literature have shown that factors associated with anastomotic leak after colorectal resection include long surgical time (>2 h), multiple blood transfusions, and short distance to the
anal
verge.
The aim of this study was to assess the morbidity associated with en bloc resection of ovarian carcinoma with low anterior resection and anastomosis in patients undergoing primary cytoreductive surgery for advanced
disease
.
[MeSH-major]
Colon, Sigmoid / surgery. Ovarian
Neoplasms
/ surgery. Rectum / surgery
Genetic Alliance.
consumer health - Ovarian cancer
.
Genetic Alliance.
consumer health - Ovarian epithelial cancer
.
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consumer health - Ovarian Cancer
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(PMID = 16153697.001).
[ISSN]
0090-8258
[Journal-full-title]
Gynecologic oncology
[ISO-abbreviation]
Gynecol. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
2.
Giger ML, Chan HP, Boone J:
Anniversary paper: History and status of CAD and quantitative image analysis: the role of Medical Physics and AAPM.
Med Phys
; 2008 Dec;35(12):5799-820
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The roles of physicists in medical imaging have expanded over the years, from the study of imaging systems (sources and detectors) and dose to the assessment of image quality and perception, the development of image processing techniques, and the development of image analysis methods to assist in detection
and diagnosis
.
In the mid-1980s, however, medical physicists and radiologists began major research efforts for computer-aided detection or computer-aided
diagnosis
(CAD), that is, using the computer output as an aid to radiologists-as opposed to a completely automatic computer interpretation-focusing initially on methods for the detection of lesions on chest radiographs and mammograms.
Since then, extensive investigations of computerized image analysis for detection or
diagnosis of
abnormalities in a variety of 2D and 3D medical images have been conducted.
[MeSH-major]
Diagnosis
, Computer-Assisted / methods. Radiometry / methods
[MeSH-minor]
Breast
Neoplasms
/
diagnosis
. Breast
Neoplasms
/ pathology. Diagnostic Imaging / methods. False Positive Reactions. Humans. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Mammography / methods. ROC Curve. Societies, Medical. Time Factors
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Med Phys. 2007 Mar;34(3):898-905
[
17441235.001
]
[Cites]
Comput Med Imaging Graph. 2007 Jun-Jul;31(4-5):198-211
[
17349778.001
]
[Cites]
IEEE Trans Med Imaging. 2008 Feb;27(2):215-27
[
18334443.001
]
[Cites]
AJR Am J Roentgenol. 2008 Apr;190(4):854-9
[
18356428.001
]
[Cites]
Acad Radiol. 2008 May;15(5):535-55
[
18423310.001
]
[Cites]
Med Phys. 2008 Apr;35(4):1559-70
[
18491550.001
]
[Cites]
Med Phys. 2008 May;35(5):2110-23
[
18561687.001
]
[Cites]
Acad Radiol. 2008 Nov;15(11):1446-57
[
18995195.001
]
[Cites]
J Digit Imaging. 2006 Dec;19(4):376-82
[
16763934.001
]
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Acad Radiol. 2007 Jan;14(1):28-37
[
17178363.001
]
[Cites]
Gastroenterology. 2006 Dec;131(6):1690-9
[
17087934.001
]
[Cites]
AJR Am J Roentgenol. 2007 Feb;188(2):377-84
[
17242245.001
]
[Cites]
Med Phys. 2007 Jan;34(1):25-36
[
17278486.001
]
[Cites]
Med Phys. 2007 Jan;34(1):140-50
[
17278499.001
]
[Cites]
Med Phys. 2007 Jan;34(1):275-81
[
17278513.001
]
(PMID = 19175137.001).
[ISSN]
0094-2405
[Journal-full-title]
Medical physics
[ISO-abbreviation]
Med Phys
[Language]
eng
[Grant]
United States / NIBIB NIH HHS / EB / R01 EB002138
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
[Publication-country]
United States
[Number-of-references]
399
[Other-IDs]
NLM/ PMC2673617
3.
Hashimoto K, Sasaki Y, Yokoyama S, Naitou A, Hiraki M, Matsumoto S, Matsuyama J, Morita S, Morimoto T, Fukushima Y, Nishisho I, Nomura T, Takeda M:
[Hepatectomy with microwave coagulation therapy for multiple liver metastases of rectal carcinoid--a case report].
Gan To Kagaku Ryoho
; 2009 Nov;36(12):2198-200
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While exploring for the primary site, we observed a flat
tumor
, 10 mm in diameter, in the rectum at 10 cm from the
anal
ring, and local resection of the
tumor
was performed transanally.
Hepatectomy with microwave coagulation therapy is believed to be locally effective in multiple liver metastases of rectal carcinoid
tumor
.
[MeSH-major]
Carcinoid
Tumor
/ pathology. Electrocoagulation / methods. Hepatectomy. Liver
Neoplasms
/ secondary. Liver
Neoplasms
/ therapy. Microwaves / therapeutic use. Rectal
Neoplasms
/ pathology
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(PMID = 20037369.001).
[ISSN]
0385-0684
[Journal-full-title]
Gan to kagaku ryoho. Cancer & chemotherapy
[ISO-abbreviation]
Gan To Kagaku Ryoho
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
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4.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG:
US intergroup anal carcinoma trial: tumor diameter predicts for colostomy.
J Clin Oncol
; 2009 Mar 1;27(7):1116-21
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[Title]
US intergroup
anal
carcinoma trial:
tumor
diameter predicts for colostomy.
PURPOSE: The US Gastrointestinal Intergroup Radiation Therapy Oncology Group 98-11
anal
carcinoma trial showed that cisplatin-based concurrent chemoradiotherapy resulted in a significantly higher rate of colostomy compared with mitomycin-based therapy.
Established prognostic variables for patients with
anal
carcinoma include
tumor
diameter, clinical nodal status, and sex, but pretreatment variables that would predict the likelihood of colostomy are unknown.
Univariate and multivariate analyses were carried out to correlate overall survival (OS),
disease
-free survival, and time to colostomy (TTC) with pretreatment and treatment variables.
In the multivariate analysis,
tumor
-related prognosticators for poorer OS included node-positive cancer (P < or = .0001), large (> 5 cm)
tumor
diameter (P = .01), and male sex (P = .016).
In the pretreatment variables category, only large
tumor
diameter independently predicted for TTC (P = .008).
Similarly, the cumulative 5-year colostomy rate was statistically significantly higher for large
tumor
diameter than for small
tumor
diameter (Gray's test; P = .0074).
CONCLUSION: The combined analysis of the two arms of RTOG 98-11, representing the largest prospective database, reveals that
tumor
diameter (irrespective of the nodal status) is the only independent pretreatment variable that predicts TTC and 5-year colostomy rate in patients with
anal
carcinoma.
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[Cites]
Cancer Chemother Rep. 1966 Mar;50(3):163-70
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[
18501454.001
]
[CommentIn]
J Clin Oncol. 2009 Jun 20;27(18):3064; author reply 3065
[
19414660.001
]
(PMID = 19139424.001).
[ISSN]
1527-7755
[Journal-full-title]
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
[ISO-abbreviation]
J. Clin. Oncol.
[Language]
ENG
[Grant]
United States / NCRR NIH HHS / RR / UL1 RR025741; United States / NCI NIH HHS / CA / CA21661; United States / NCI NIH HHS / CA / U10 CA37422; United States / NCI NIH HHS / CA / U10 CA037422; United States / NCI NIH HHS / CA / U10 CA021661; United States / NCI NIH HHS / CA / U10CA32115; United States / NCI NIH HHS / CA / U10 CA032115
[Publication-type]
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
[Other-IDs]
NLM/ PMC2667813
5.
Cho SD, Herzig DO, Douthit MA, Deveney KE:
Treatment strategies and outcomes for rectal villous adenoma from a single-center experience.
Arch Surg
; 2008 Sep;143(9):866-70; discussion 871-2
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DESIGN: Retrospective review of patient
and tumor
characteristics, procedure, recurrence, and complications.
Mean
tumor
size was 3.0 cm (range, 0.5-11 cm) and the mean distance of the
tumor
from the
anal
verge was 4.9 cm (range, 0-10 cm).
Tumor
size did not correlate with malignancy.
There were 4 (12.5%)
benign
recurrences, all after transanal excisions.
[MeSH-major]
Adenoma, Villous / surgery. Rectal
Neoplasms
/ surgery
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Biopsy. Endosonography. Female. Humans. Male. Middle Aged.
Neoplasm
Recurrence, Local / epidemiology.
Neoplasm
Recurrence, Local / pathology. Retrospective Studies
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(PMID = 18794424.001).
[ISSN]
1538-3644
[Journal-full-title]
Archives of surgery (Chicago, Ill. : 1960)
[ISO-abbreviation]
Arch Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
6.
Pollack J, Holm T, Cedermark B, Altman D, Holmström B, Glimelius B, Mellgren A:
Late adverse effects of short-course preoperative radiotherapy in rectal cancer.
Br J Surg
; 2006 Dec;93(12):1519-25
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RESULTS: Overall, patients who had preoperative radiotherapy experienced significantly more late complications than those who did not (69 versus 43
per
cent; P = 0.002).
This morbidity consisted mainly of cardiovascular
disease
(35 versus 19
per
cent; P = 0.032), faecal incontinence (12 of 21 versus 11 of 42 patients having anterior resection; P = 0.013) and urinary incontinence (45 versus 27
per
cent; P = 0.023).
CONCLUSION: Preoperative short-course, high-dose radiotherapy in patients with rectal cancer increases the risk of
anal
and urinary dysfunction, and may lead to increased cardiovascular morbidity, at long-term follow-up.
[MeSH-major]
Quality of Life. Radiotherapy, Adjuvant / adverse effects. Rectal
Neoplasms
/ radiotherapy
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consumer health - Rectal Cancer
.
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(PMID = 17054311.001).
[ISSN]
0007-1323
[Journal-full-title]
The British journal of surgery
[ISO-abbreviation]
Br J Surg
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
[Publication-country]
England
7.
Giorgini S, Barbisan F, Morichetti D, Mazzucchelli R, Marzioni D:
PUNLMP or not PUNLMP? This is the problem.
Anal Quant Cytol Histol
; 2009 Jun;31(3):184-5
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[Title]
PUNLMP or not PUNLMP? This is the problem.
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(PMID = 19634789.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Letter
[Publication-country]
United States
8.
Case BW:
Asbestos, smoking, and lung cancer: interaction and attribution.
Occup Environ Med
; 2006 Aug;63(8):507-8
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[MeSH-major]
Asbestos / adverse effects. Lung
Neoplasms
/ etiology. Smoking / adverse effects
Genetic Alliance.
consumer health - Lung Cancer
.
MedlinePlus Health Information.
consumer health - Asbestos
.
MedlinePlus Health Information.
consumer health - Lung Cancer
.
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consumer health - Smoking
.
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.
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[Cites]
Cancer Res. 1983 Mar;43(3):1251-5
[
6297722.001
]
[Cites]
Free Radic Biol Med. 2000 Apr 15;28(8):1295-9
[
10889460.001
]
[Cites]
Ann Occup Hyg. 2000 Dec;44(8):565-601
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Occup Environ Med. 2006 Aug;63(8):509-12
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[
16126764.001
]
[CommentOn]
Occup Environ Med. 2006 Aug;63(8):509-12
[
16849527.001
]
(PMID = 16849526.001).
[ISSN]
1470-7926
[Journal-full-title]
Occupational and environmental medicine
[ISO-abbreviation]
Occup Environ Med
[Language]
eng
[Publication-type]
Comment; Journal Article
[Publication-country]
England
[Chemical-registry-number]
1332-21-4 / Asbestos
[Other-IDs]
NLM/ PMC2078131
9.
Pronio A, Di Filippo A, Narilli P, Mancini B, Caporilli D, Piroli S, Vestri A, Montesani C:
[Anastomotic dehiscence in colorectal surgery. Analysis of 1290 patients].
Chir Ital
; 2007 Sep-Oct;59(5):599-609
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The variables considered were the following: age; sex; type
of disease
; elective or emergency surgery; type of surgery; type, design and site (intra or extra peritoneal) of the anastomosis; stapled or manual anastomosis; distance from
anal
verge of the colorectal anastomosis; intraoperative complications; protective stoma.
Significant factors were: the type of surgery (higher risk after restorative proctocolectomy or rectal resection), the site extra peritoneal of the anastomosis, the type of the anastomosis (higher risk after coloanal or ileal-pouch
anal
or colorectal), the stapled anastomosis, the intraoperative complications.
[MeSH-major]
Colon / surgery. Colorectal
Neoplasms
/ surgery. Proctocolectomy, Restorative. Rectum / surgery. Surgical Wound Dehiscence / etiology
[MeSH-minor]
Adult. Aged.
Anal
Canal / surgery. Anastomosis, Surgical. Female. Humans. Male. Middle Aged. Retrospective Studies. Risk Assessment. Treatment Outcome
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(PMID = 18019632.001).
[ISSN]
0009-4773
[Journal-full-title]
Chirurgia italiana
[ISO-abbreviation]
Chir Ital
[Language]
ita
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Italy
10.
Shrikhande SV, Saoji RR, Barreto SG, Kakade AC, Waterford SD, Ahire SB, Goliwale FM, Shukla PJ:
Outcomes of resection for rectal cancer in India: the impact of the double stapling technique.
World J Surg Oncol
; 2007;5:35
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RESULTS: A total of 77 out of 78 patients in the SST group had Astler Coller B and C
disease
while the number was 132/138 in the DST group.
The mean distance of the
tumor
from
anal
verge was 7.6 cm (2.5-15 cm) and 8.0 cm (4-15 cm) in the DST and SST groups, respectively.
The observed improvement of surgical outcomes with DST needs further studies to significantly prove these findings in a population where
the tumors
at presentation are predominantly Astler Coller Stage B and C.
[MeSH-major]
Adenocarcinoma / surgery. Rectal
Neoplasms
/ surgery. Rectum / surgery. Surgical Stapling
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.
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NCI CPTAC Assay Portal
.
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(PMID = 17374176.001).
[ISSN]
1477-7819
[Journal-full-title]
World journal of surgical oncology
[ISO-abbreviation]
World J Surg Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC1839092
[General-notes]
NLM/ Original DateCompleted: 20070726
11.
Triantafillidis JK, Nasioulas G, Kosmidis PA:
Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
Anticancer Res
; 2009 Jul;29(7):2727-37
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[Title]
Colorectal cancer and inflammatory bowel
disease
: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies.
Patients with long-standing ulcerative colitis and Crohn's
disease
have an increased risk of developing colorectal cancer and patients with small intestinal Crohn's
disease
are at increased risk of small bowel adenocarcinoma.
Colorectal cancer appearing on the ground of inflammatory bowel
disease
is the result of a process which is believed to begin from no dysplasia progressing to indefinite dysplasia, low-grade dysplasia, high-grade dysplasia and finally to invasive adenocarcinoma, although colorectal cancer can arise without proceeding through each of these steps.
Ulcerative colitis patients with total proctocolectomy and ileal pouch
anal
-anastomosis have a rather low risk of dysplasia in the ileal pouch, although the
anal
transition zone should be monitored periodically, especially if chronic pouchitis is present with associated severe villous atrophy.
Concerning the risk factors predisposing to colorectal cancer in the setting of ulcerative colitis or Crohn's
disease
, it seems that the risk increases with longer duration and greater anatomic extent of colitis, the degree of inflammation, and the presence of primary sclerosing cholangitis and family history of colorectal cancer.
[MeSH-major]
Cell Transformation, Neoplastic. Colorectal
Neoplasms
/ epidemiology. Inflammatory Bowel Diseases / epidemiology
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(PMID = 19596953.001).
[ISSN]
1791-7530
[Journal-full-title]
Anticancer research
[ISO-abbreviation]
Anticancer Res.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Greece
[Number-of-references]
94
12.
Mistrangelo M, Cassoni P, Scozzari G, Castellano I, Gavello G, Corno F, Morino M:
Perianal granular cell tumor: report of a case and review of the literature.
Tumori
; 2009 Jul-Aug;95(4):538-41
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[Title]
Perianal granular cell
tumor
: report of a case and review of the literature.
INTRODUCTION: Granular cell
tumor
was first described by Abrikossoff in 1926.
Over the years several cases of this
neoplasm
have been reported, with a variety of localizations.
We here report a case of perianal granular cell
tumor and
discuss its histogenesis and its relevance to clinical practice.
Pathological examination revealed a granular cell
tumor
.
A literature search produced only 25 other cases of
anal
and perianal granular cell
tumors
.
CONCLUSIONS: Granular cell
tumors
are rarely observed in the perianal region.
Their existence must always be borne in mind in the differential
diagnosis of
perianal
neoplasms
.
In most cases surgical excision is curative, but potential
malignant
transformation must be considered during therapeutic procedures and follow-up.
[MeSH-major]
Anus
Neoplasms
/ pathology
[MeSH-minor]
Female. Granular Cell
Tumor
/ pathology. Granular Cell
Tumor
/ surgery. Humans. Middle Aged
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(PMID = 19856672.001).
[ISSN]
0300-8916
[Journal-full-title]
Tumori
[ISO-abbreviation]
Tumori
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
United States
[Number-of-references]
21
13.
Lopez-Beltran A:
Urothelial changes induced by therapeutic procedures for bladder cancer.
Anal Quant Cytol Histol
; 2006 Dec;28(6):339
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[Title]
Urothelial changes induced by therapeutic procedures for bladder cancer.
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[CommentOn]
Anal Quant Cytol Histol. 2005 Feb;27(1):27-34
[
15794449.001
]
(PMID = 17220148.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Comment; Letter
[Publication-country]
United States
14.
Nguyen BT, Joon DL, Khoo V, Quong G, Chao M, Wada M, Joon ML, See A, Feigen M, Rykers K, Kai C, Zupan E, Scott A:
Assessing the impact of FDG-PET in the management of anal cancer.
Radiother Oncol
; 2008 Jun;87(3):376-82
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[Title]
Assessing the impact of FDG-PET in the management of
anal
cancer.
PURPOSE: To assess the utility of FDG-PET in
anal
cancer for staging and impact on radiotherapy planning (RTP), response and detection of recurrent
disease
.
METHODS AND MATERIALS: Fifty histopathological
anal
cancer patients were reviewed between 1996 and 2006.
Impact on management,
disease
response, recurrence and metastases was evaluated.
The primary was strongly FDG avid in 98% with non-excised
tumors
compared to CT (58%).
PET upstaged 17% with unsuspected pelvic/inguinal nodal
disease
.
CONCLUSIONS:
Anal
cancer is FDG-PET avid.
PET can aid in
anal
cancer staging and identification of residual
disease
, recurrent/metastatic
disease
but warrants further prospective studies.
[MeSH-major]
Anus
Neoplasms
/ radionuclide imaging. Carcinoma, Squamous Cell / radionuclide imaging. Fluorodeoxyglucose F18. Positron-Emission Tomography. Radiopharmaceuticals
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(PMID = 18453023.001).
[ISSN]
0167-8140
[Journal-full-title]
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
[ISO-abbreviation]
Radiother Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
15.
Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I:
Regulation of SIRT1 in cellular functions: role of polyphenols.
Arch Biochem Biophys
; 2010 Sep 1;501(1):79-90
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[Title]
Regulation of SIRT1 in cellular functions: role of polyphenols.
Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance, cellular survival, cellular senescence/aging, inflammation-immune function, endothelial functions, and circadian rhythms.
Naturally occurring dietary polyphenols, such as resveratrol, curcumin, quercetin, and catechins, have antioxidant and anti-inflammatory properties via modulating different pathways, such as NF-kappaB- and mitogen activated protein kinase-dependent signaling pathways.
In addition, these polyphenols have also been shown to activate SIRT1 directly or indirectly in a variety of models.
Therefore, activation of SIRT1 by polyphenols is beneficial for regulation of calorie restriction, oxidative stress, inflammation, cellular senescence, autophagy/apoptosis, autoimmunity, metabolism, adipogenesis, circadian rhythm, skeletal muscle function, mitochondria biogenesis and endothelial dysfunction.
In this review, we describe the regulation of SIRT1 by dietary polyphenols in various cellular functions in response to environmental and pro-inflammatory stimuli.
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[Copyright]
2010 Elsevier Inc. All rights reserved.
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Biochem Biophys Res Commun. 2010 Jan 1;391(1):6-10
[
19912989.001
]
(PMID = 20450879.001).
[ISSN]
1096-0384
[Journal-full-title]
Archives of biochemistry and biophysics
[ISO-abbreviation]
Arch. Biochem. Biophys.
[Language]
ENG
[Grant]
United States / NHLBI NIH HHS / HL / R01 HL092842-02; United States / NHLBI NIH HHS / HL / R01 HL085613-02W1; United States / NHLBI NIH HHS / HL / R01 HL085613-01A2; United States / NHLBI NIH HHS / HL / R01 HL085613-03; United States / NIEHS NIH HHS / ES / P30 ES001247; United States / NHLBI NIH HHS / HL / 1R01HL097751; United States / NHLBI NIH HHS / HL / R01 HL085613-04; United States / NHLBI NIH HHS / HL / R01 HL085613; United States / NHLBI NIH HHS / HL / R01 HL092842; United States / NHLBI NIH HHS / HL / R01 HL097751-02; United States / NIEHS NIH HHS / ES / P30-ES01247; United States / NHLBI NIH HHS / HL / R01 HL092842-01A2; United States / NHLBI NIH HHS / HL / 1R01HL092842; United States / NHLBI NIH HHS / HL / 1R01HL085613; United States / NHLBI NIH HHS / HL / R01 HL097751; United States / NHLBI NIH HHS / HL / R01 HL097751-01; United States / NHLBI NIH HHS / HL / R01 HL085613-02
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Flavonoids; 0 / Phenols; 0 / Polyphenols; 0U46U6E8UK / NAD; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.5.1.- / Sirtuin 1
[Number-of-references]
230
[Other-IDs]
NLM/ NIHMS208121; NLM/ PMC2930135
16.
Peeters ST, Lebesque JV, Heemsbergen WD, van Putten WL, Slot A, Dielwart MF, Koper PC:
Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer.
Int J Radiat Oncol Biol Phys
; 2006 Mar 15;64(4):1151-61
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[Title]
Localized volume effects for late rectal and
anal
toxicity after radiotherapy for prostate cancer.
PURPOSE: To identify dosimetric parameters derived from anorectal, rectal, and
anal
wall dose distributions that correlate with different late gastrointestinal (GI) complications after three-dimensional conformal radiotherapy for prostate cancer.
The variables derived from dose-volume histogram of anorectal, rectal, and
anal
wall were as follows: % receiving > or =5-70 Gy (V5-V70), maximum dose (Dmax), and mean dose (D(mean)).
The anus
was defined as the most caudal 3 cm of the anorectum.
RESULTS:
Anal
dosimetric variables were associated with RTOG/EORTC Grade > or =2 (V5-V40, D(mean)) and incontinence (V5-V70, D(mean)).
Use of steroids was weakly related to
anal
variables.
Therefore, to evaluate the risk of late GI toxicity, not only intermediate and high doses to the anorectal wall volume should be taken into account, but also the dose to the
anal
wall.
[MeSH-major]
Anal
Canal / radiation effects. Prostatic
Neoplasms
/ radiotherapy. Radiotherapy, Conformal / adverse effects. Rectum / radiation effects
Genetic Alliance.
consumer health - Anal Cancer
.
Genetic Alliance.
consumer health - Rectal Cancer
.
Genetic Alliance.
consumer health - Prostate cancer
.
MedlinePlus Health Information.
consumer health - Prostate Cancer
.
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.
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(PMID = 16414208.001).
[ISSN]
0360-3016
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
[Publication-country]
United States
17.
Yücesoy AN, Ercan Bülbül E, Bahat R, Cafer Köşkeroğlu C:
Transvaginal low anterior resection for rectal cancer.
Tech Coloproctol
; 2008 Mar;12(1):83-5; discussion 85-6
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We have performed a low anterior resection for rectal cancer in a 69-year-old woman with mobilisation of the
tumour and
anastomosis performed transvaginally without a covering stoma.
This way we could get good exposure of the lower rectum and
anal
sphincters.
[MeSH-major]
Adenocarcinoma / surgery. Digestive System Surgical Procedures / methods. Rectal
Neoplasms
/ surgery. Vagina
Genetic Alliance.
consumer health - Rectal Cancer
.
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[Cites]
Ann Surg. 1996 Nov;224(5):603-8
[
8916875.001
]
[Cites]
Colorectal Dis. 2004 Jul;6(4):275-9
[
15206973.001
]
[Cites]
Dis Colon Rectum. 1996 May;39(5):582-3
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Cancer Control. 2003 May-Jun;10(3):212-8
[
12794619.001
]
[Cites]
Tex Med. 1973 Sep;69(9):65-9
[
4745938.001
]
(PMID = 18512019.001).
[ISSN]
1123-6337
[Journal-full-title]
Techniques in coloproctology
[ISO-abbreviation]
Tech Coloproctol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Italy
18.
Joseph DA, Miller JW, Wu X, Chen VW, Morris CR, Goodman MT, Villalon-Gomez JM, Williams MA, Cress RD:
Understanding the burden of human papillomavirus-associated anal cancers in the US.
Cancer
; 2008 Nov 15;113(10 Suppl):2892-900
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[Title]
Understanding the burden of human papillomavirus-associated
anal
cancers in the US.
BACKGROUND:
Anal
cancer is an uncommon malignancy in the US; up to 93% of
anal
cancers are associated with human papillomavirus.
The following
anal
cancer histologies were included in the analysis: squamous cell, adenocarcinoma, and small cell/neuroendocrine carcinomas.
RESULTS: From 1998 through 2003, the annual age-adjusted invasive
anal
cancer incidence rate was 1.5
per
100,000 persons.
Squamous cell carcinoma (SCC) was the most common histology overall, accounting for 18,105 of 21,395 (84.6%) cases of
anal
cancer.
Women had a higher rate of SCC (1.5
per
100,000) than men (1.0).
Incidence rates of
anal
SCC increased 2.6%
per
year on average.
API were more likely to be diagnosed with regional or distant stage
disease
than were other racial/ethnic groups (27.5% and 11.8%, respectively).
Males had lower 5-year relative survival than females for all stages
of disease
.
CONCLUSIONS: Rates of
anal
SCC varied by sex, race, and ethnicity.
Continued surveillance and additional research are needed to assess the potential impact of the HPV vaccine on the
anal
cancer burden in the US.
MedlinePlus Health Information.
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.
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.
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J Natl Cancer Inst. 2000 Sep 20;92(18):1500-10
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Cancer. 2000 Mar 15;88(6):1464-9
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Clin Infect Dis. 2002 Nov 1;35(9):1127-34
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Dan Med Bull. 2002 Aug;49(3):194-209
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12238281.001
]
(PMID = 18980293.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
ENG
[Grant]
None / None / / N01 PC035137; United States / NCCDPHP CDC HHS / DP / U50 DP424071; United States / NCI NIH HHS / PC / N01 PC035137; United States / NCCDPHP CDC HHS / DP / U50 DP424071-04
[Publication-type]
Journal Article; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Other-IDs]
NLM/ NIHMS104103; NLM/ PMC2729501
19.
Al-Niaimi F, Lyon CC:
Primary adenocarcinoma in peristomal skin: a case study.
Ostomy Wound Manage
; 2010 Jan 1;56(1):45-7
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Biopsy of newly developing lesions in the peristomal area of long-standing stomas is essential in order to avoid delayed
diagnosis and
limit complications.
The lesion was removed surgically, an ileo-
anal
J pouch was created, and the patient is currently receiving long-term follow-up and monitoring for any possible future complications.
[MeSH-major]
Adenocarcinoma / complications. Colitis, Ulcerative / surgery. Ileostomy / adverse effects. Skin
Neoplasms
/ complications
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consumer health - Skin Cancer
.
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(PMID = 20093717.001).
[ISSN]
1943-2720
[Journal-full-title]
Ostomy/wound management
[ISO-abbreviation]
Ostomy Wound Manage
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
20.
Bellutti M, Fry LC, Schmitt J, Seemann M, Klose S, Malfertheiner P, Mönkemüller K:
Detection of neuroendocrine tumors of the small bowel by double balloon enteroscopy.
Dig Dis Sci
; 2009 May;54(5):1050-8
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[Title]
Detection of neuroendocrine
tumors of
the small bowel by double balloon enteroscopy.
BACKGROUND: Neuroendocrine
tumors
(NET) account for one-third of all small bowel
neoplasms
.
The search for the primary
tumor
in NET is important, even though it is difficult to localize, as its surgical excision leads to a better prognosis, even in metastasized stages of the
disease
.
The objective of this study was to evaluate the use of double balloon enteroscopy (DBE) for the detection of the primary
tumor
in patients with NET.
METHODS: Twelve consecutive patients (eight women, four men) with suspected carcinoid syndrome, either metastatic to the liver (n=5), symptoms of a neuroendocrine
tumor
with elevated
tumor
markers (n=5), or obscure gastrointestinal bleeding (n=2) underwent DBE for the search of the primary
tumor
or the source of bleeding.
The CT scan and sonography of the abdomen as well as EGD and ileocolonoscopy were unable to detect the primary
tumor
in any patient.
A submucosal
tumor of
the ileum or the jejunum could be detected by DBE was detected in seven patients (58%) (
anal
route, n=4; oral route, n=3).
In four of these patients (33%) this
finding
could be confirmed by the surgical resection of a NET.
In two patients (17%) with a submucosal ileum protrusion suspicious for NET, laparotomy and intraoperative endoscopy did not confirm
the tumor
.
CONCLUSIONS: In this study, the diagnostic yield of DBE for primary
tumor
search in patients with metastatic or suspected NET was 33%.
Although endoscopic small bowel investigation by DBE seems to enrich the diagnostic possibilities for
the diagnosis
of small bowel-NET, at the present time DBE should only be performed in selected cases, possibly based on a positive previous work-up.
[MeSH-major]
Endoscopy, Gastrointestinal / methods. Gastrointestinal Hemorrhage / etiology. Intestinal
Neoplasms
/ pathology. Intestine, Small / pathology. Liver
Neoplasms
/ secondary.
Malignant
Carcinoid Syndrome / pathology. Neuroendocrine
Tumors
/ pathology
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.
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.
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15838182.001
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Eur J Endocrinol. 2004 Jul;151(1):15-27
[
15248818.001
]
(PMID = 18770038.001).
[ISSN]
1573-2568
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Radiopharmaceuticals; RWM8CCW8GP / Octreotide
21.
Barr E, Sings HL:
Prophylactic HPV vaccines: new interventions for cancer control.
Vaccine
; 2008 Nov 18;26(49):6244-57
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Human Papillomavirus (HPV) infection causes cervical cancer, a significant portion of
anal
, vulvar, vaginal, and oropharyngeal cancers, genital warts, and recurrent respiratory papillomatosis (RRP).
Together these four types cause 30-50% of all cervical intraepithelial
neoplasia
such as those detected by Papinicalou screening.
[MeSH-major]
Genital
Neoplasms
, Female / prevention & control. Papillomavirus Vaccines / therapeutic use
[MeSH-minor]
Adolescent. Adult. Animals. Condylomata Acuminata / immunology. Condylomata Acuminata / prevention & control. Cost of Illness. Female. Humans. Immunization Programs. Male.
Neoplasms
, Squamous Cell / immunology.
Neoplasms
, Squamous Cell / pathology.
Neoplasms
, Squamous Cell / prevention & control. Papillomavirus Infections / economics. Papillomavirus Infections / transmission. Rectal
Neoplasms
/ immunology. Rectal
Neoplasms
/ prevention & control. Uterine Cervical
Neoplasms
/ immunology. Uterine Cervical
Neoplasms
/ pathology. Uterine Cervical
Neoplasms
/ prevention & control. Vaginal
Neoplasms
/ immunology. Vaginal
Neoplasms
/ pathology. Vaginal
Neoplasms
/ prevention & control. Vulvar
Neoplasms
/ immunology. Vulvar
Neoplasms
/ pathology. Vulvar
Neoplasms
/ prevention & control. Young Adult
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(PMID = 18694795.001).
[ISSN]
0264-410X
[Journal-full-title]
Vaccine
[ISO-abbreviation]
Vaccine
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Papillomavirus Vaccines
[Number-of-references]
116
22.
Kreuter A, Wieland U, Gambichler T, Altmeyer P, Pfister H, Tenner-Racz K, Racz P, Potthoff A, Brockmeyer NH, German Network of Competence HIV/AIDS:
p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load.
Br J Dermatol
; 2007 Sep;157(3):523-30
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[Title]
p16ink4a expression decreases during imiquimod treatment of
anal
intraepithelial
neoplasia
in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load.
In this context, a drastically increased relative risk for
anal
intraepithelial
neoplasia
(AIN) exists in HIV-infected men having sex with men (MSM).
[MeSH-major]
Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use.
Anus
Neoplasms
/ drug therapy. Carcinoma in Situ / drug therapy. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Precancerous Conditions / drug therapy
[MeSH-minor]
AIDS-Related Opportunistic Infections / complications. Administration, Cutaneous. Adult. Biomarkers,
Tumor
/ metabolism. DNA, Viral / analysis. Homosexuality, Male. Humans. Ki-67 Antigen / metabolism. Male. Papillomaviridae / genetics. Papillomavirus Infections / complications. Papillomavirus Infections / metabolism. Pilot Projects. Viral Load
MedlinePlus Health Information.
consumer health - Anal Cancer
.
MedlinePlus Health Information.
consumer health - Cancer Chemotherapy
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
Hazardous Substances Data Bank.
Imiquimod
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 17573882.001).
[ISSN]
0007-0963
[Journal-full-title]
The British journal of dermatology
[ISO-abbreviation]
Br. J. Dermatol.
[Language]
eng
[Databank-accession-numbers]
ClinicalTrials.gov/ NCT00365729
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / Ki-67 Antigen; 99011-02-6 / imiquimod
23.
Orsenigo E, Di Palo S, Vignali A, Staudacher C:
Laparoscopic intersphincteric resection for low rectal cancer.
Surg Oncol
; 2007 Dec;16 Suppl 1:S117-20
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Nevertheless, all progress in the development of oncologic therapy (i.e., radiation and chemotherapy), radical surgical removal of the
tumour
is the only chance for permanent cure of rectal cancer.
Information concerning the depth
of tumour
penetration through the rectal wall, lymph node involvement, and presence of distant metastatic
disease
is of crucial importance when planning a curative rectal cancer resection.
Laparoscope-assisted
anal
sphincter-preserving operation preceded by transanal procedure.
Colorectal
Disease
2003;5:451-3; Rullier E, Sa Cunha A, Couderc P, Rullier A, Gontier R, Saric J.
Laparoscopic ultralow anterior resection combined with
per
anum intersphincteric rectal dissection for lower rectal cancer.
Hopefully, randomized controlled trials, which utilize these alternative procedures, will in future determine the results of laparoscopic ISR in terms of sphincter function, faecal continence,
disease
free and overall survival.
[MeSH-major]
Anal
Canal / surgery. Digestive System Surgical Procedures / methods. Laparoscopy. Rectal
Neoplasms
/ surgery
Genetic Alliance.
consumer health - Rectal Cancer
.
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(PMID = 18023571.001).
[ISSN]
0960-7404
[Journal-full-title]
Surgical oncology
[ISO-abbreviation]
Surg Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
24.
Sahni VA, Silverman SG:
Biopsy of renal masses: when and why.
Cancer Imaging
; 2009;9:44-55
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Although once reserved for
the diagnosis
of unresectable renal cell carcinoma, metastases, lymphoma, and infection, today percutaneous image-guided biopsy has an expanded role.
There is increasing awareness that a substantial proportion of small, solid renal masses are
benign
neoplasms
.
Based largely on advances in cytological techniques, percutaneous biopsy can be now be used to diagnose
benign
neoplasms
and thus prevent them from being treated unnecessarily.
[MeSH-major]
Biopsy, Needle / methods. Kidney
Neoplasms
/ pathology
[MeSH-minor]
Diagnosis
, Computer-Assisted / methods.
Diagnosis
, Differential. Humans. Kidney Diseases / pathology. Patient Selection. Sensitivity and Specificity
MedlinePlus Health Information.
consumer health - Kidney Cancer
.
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author profiles
.
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(PMID = 19602467.001).
[ISSN]
1470-7330
[Journal-full-title]
Cancer imaging : the official publication of the International Cancer Imaging Society
[ISO-abbreviation]
Cancer Imaging
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Number-of-references]
112
[Other-IDs]
NLM/ PMC2739685
25.
Simeonov R, Simeonova G:
Computerized cytomorphometric analysis of nuclear area, nuclear perimeter and mean nuclear diameter in spontaneous canine mammary gland tumours.
Vet Res Commun
; 2007 Jul;31(5):553-8
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A minimum of 100 nuclei
per
lesion were examined.
The statistical analysis revealed statistically significant differences between
benign and malignant
neoplasms
.
The results indicated that computer-assisted nuclear morphometry could be used as an additional method for differentiation
of benign
from
malignant
canine mammary gland tumours in cytological specimens.
[MeSH-major]
Cell Nucleus. Cytological Techniques / veterinary. Dog Diseases / pathology. Histological Techniques / veterinary. Mammary
Neoplasms
, Animal / pathology
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[ISSN]
0165-7380
[Journal-full-title]
Veterinary research communications
[ISO-abbreviation]
Vet. Res. Commun.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
26.
Fernández-Fernández FJ, Buño-Ramilo B, Alvarez-Fernández JC, Brage-Gómez MS, Nogueira C:
[Paraneoplastic hypercalcemia associated with a rectal epidermoid tumor in a patient with a long-standing anal fistula].
Gastroenterol Hepatol
; 2010 Aug-Sep;33(7):551-3
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[Title]
[Paraneoplastic hypercalcemia associated with a rectal epidermoid
tumor
in a patient with a long-standing
anal
fistula].
[Transliterated title]
Hipercalcemia paraneoplásica asociada a una tumoración epidermoide rectal en una paciente con fístula
anal
de
larga duración.
[MeSH-major]
Carcinoma, Squamous Cell / complications. Hypercalcemia / etiology. Paraneoplastic Syndromes / etiology. Rectal Fistula / complications. Rectal
Neoplasms
/ complications
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(PMID = 20381202.001).
[ISSN]
0210-5705
[Journal-full-title]
Gastroenterología y hepatología
[ISO-abbreviation]
Gastroenterol Hepatol
[Language]
spa
[Publication-type]
Case Reports; Letter
[Publication-country]
Spain
27.
Clifford GM, Polesel J, Rickenbach M, Dal Maso L, Keiser O, Kofler A, Rapiti E, Levi F, Jundt G, Fisch T, Bordoni A, De Weck D, Franceschi S, Swiss HIV Cohort:
Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy.
J Natl Cancer Inst
; 2005 Mar 16;97(6):425-32
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Statistically significantly elevated SIRs were also observed for
anal
cancer (SIR = 33.4, 95% CI = 10.5 to 78.6); Hodgkin lymphoma (SIR = 17.3, 95% CI = 10.2 to 27.4); cancers of the cervix (SIR = 8.0, 95% CI = 2.9 to 17.4); liver (SIR = 7.0, 95% CI = 2.2 to 16.5); lip, mouth, and pharynx (SIR = 4.1, 95% CI = 2.1 to 7.4); trachea, lung, and bronchus (SIR = 3.2, 95% CI = 1.7 to 5.4); and skin, nonmelanomatous (SIR = 3.2, 95% CI = 2.2 to 4.5).
[MeSH-major]
Antiretroviral Therapy, Highly Active. CD4-Positive T-Lymphocytes. HIV Infections / complications. HIV Infections / drug therapy.
Neoplasms
/ epidemiology.
Neoplasms
/ etiology. Smoking / adverse effects
[MeSH-minor]
Adult. Aged. Cohort Studies. Confounding Factors (Epidemiology). Female. Humans. Incidence. Lymphocyte Count. Lymphoma, AIDS-Related / epidemiology. Lymphoma, Non-Hodgkin / epidemiology. Lymphoma, Non-Hodgkin / virology. Male. Medical Record Linkage. Middle Aged. Odds Ratio. Papillomaviridae. Prospective Studies. Registries. Research Design. Risk Assessment. Risk Factors. Sarcoma, Kaposi / epidemiology. Sarcoma, Kaposi / virology. Switzerland / epidemiology. Uterine Cervical
Neoplasms
/ epidemiology. Uterine Cervical
Neoplasms
/ virology
Genetic Alliance.
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MedlinePlus Health Information.
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.
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.
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consumer health - Smoking
.
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[CommentIn]
J Natl Cancer Inst. 2005 Mar 16;97(6):407-9
[
15769998.001
]
(PMID = 15770006.001).
[ISSN]
1460-2105
[Journal-full-title]
Journal of the National Cancer Institute
[ISO-abbreviation]
J. Natl. Cancer Inst.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
28.
Liu BS, Xu L, Yan J, Liu C, Zheng YC:
[Experience of ultralow anterior excision for rectal cancer: 508 cases analysis].
Zhonghua Wai Ke Za Zhi
; 2008 Nov 15;46(22):1712-5
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METHODS: From October 1996 to October 2006, 508 cases with rectal carcinoma at or below the peritoneal reflection with potential to preserve the
anal
function were divided into two groups.
Of the patients, 365 cases underwent ultralow anterior excision and instrumental anastomosis, and 143 cases underwent manual colon-
anal
anastomosis (Parks operation).
In the Parks operation group, the anastomosis was carried out manually at
the anus
and in abdominal cavity.
[MeSH-major]
Anastomosis, Surgical / methods. Rectal
Neoplasms
/ surgery
[MeSH-minor]
Anal
Canal / surgery. Follow-Up Studies. Humans. Treatment Outcome
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(PMID = 19094730.001).
[ISSN]
0529-5815
[Journal-full-title]
Zhonghua wai ke za zhi [Chinese journal of surgery]
[ISO-abbreviation]
Zhonghua Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
29.
Roldán GB, Chan AK, Buckner M, Magliocco AM, Doll CM:
The prognostic value of hemoglobin in patients with anal cancer treated with chemoradiotherapy.
Dis Colon Rectum
; 2010 Aug;53(8):1127-34
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[Title]
The prognostic value of hemoglobin in patients with
anal
cancer treated with chemoradiotherapy.
PURPOSE: This study aimed to evaluate the impact of hemoglobin level on clinical outcome (local response, progression-free survival, and overall survival) in patients with carcinoma of the
anal
canal treated with definitive chemoradiotherapy.
METHODS: This is a retrospective study of patients with
anal
cancer treated between 1992 and 2005 with definitive chemoradiotherapy at Tom Baker Cancer Centre.
The median age was 56 years, the male-to-female ratio was 1:2, and the median
tumor
size was 3.5 cm.
CONCLUSIONS: Hemoglobin status was correlated with progression-free and overall survival, and distant relapse, but not clinical response, in patients with carcinoma of the
anal
canal treated with chemoradiotherapy.
[MeSH-major]
Antineoplastic Agents / therapeutic use.
Anus
Neoplasms
/ blood. Hemoglobins / metabolism
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Biomarkers,
Tumor
/ blood. Female. Follow-Up Studies. Humans. Male. Middle Aged.
Neoplasm
Staging. Prognosis. Radiotherapy, Adjuvant. Retrospective Studies
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(PMID = 20628275.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Hemoglobins
30.
Riethmuller D:
[Ano-genital papillomavirus infections in women].
Rev Prat
; 2006 Nov 15;56(17):1893-900
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[Title]
[
Ano
-genital papillomavirus infections in women].
[Transliterated title]
Lésions
ano
-génitales a papillomavirus chez la femme.
Ano
-genital papillomavirus infections in women are caused by high-risk human papillomaviruses (HPV) involved in cervical carcinogenesis (but also, to a lesser extent, in vaginal, vulvar and
anal
carcinogenesis) or by low-risk HPV responsible for condylomata acuminata, which may be peri-
anal
, perineal, vulvar or vaginal (less often cervical).
[MeSH-major]
Papillomavirus Infections / transmission. Uterine Cervical Dysplasia / virology. Uterine Cervical
Neoplasms
/ virology
MedlinePlus Health Information.
consumer health - Cervical Cancer
.
International Agency for Research on Cancer - Screening Group.
diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers
.
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(PMID = 17243387.001).
[ISSN]
0035-2640
[Journal-full-title]
La Revue du praticien
[ISO-abbreviation]
Rev Prat
[Language]
fre
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
France
[Chemical-registry-number]
0 / Papillomavirus Vaccines
[Number-of-references]
17
31.
Zhou BJ, Song WQ, Yan QH, Cai JH, Wang FA, Liu J, Zhang GJ, Duan GQ, Zhang ZX:
Ultrasonically activated scalpel versus monopolar electrocautery shovel in laparoscopic total mesorectal excision for rectal cancer.
World J Gastroenterol
; 2008 Jul 7;14(25):4065-9
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AIM: To investigate the feasibility and safety of monopolar electrocautery shovel (ES) in laparoscopic total mesorectal excision (TME) with
anal
sphincter preservation for rectal cancer in order to reduce the cost of the laparoscopic operation, and to compare ES with the ultrasonically activated scalpel (US).
METHODS: Forty patients with rectal cancer, who underwent laparoscopic TME with
anal
sphincter preservation from June 2005 to June 2007, were randomly divided into ultrasonic scalpel group and monopolar ES group, prospectively.
White blood cells (WBC) were measured before and after operation, operative time, blood loss, pelvic volume of drainage, time of
anal
exhaust, visual analogue scales (VAS) and surgery-related complications were recorded.
No significant differences were observed in terms of preoperative and postoperative d 1 and d 3 WBC counts (P=0.493, P=0.375, P=0.559), operation time (P=0.235), blood loss (P=0.296),
anal
exhaust time (P=0.431), pelvic drainage volume and VAS in postoperative d 1 (P=0.431, P=0.426) and d 3 (P=0.844, P=0.617) between ES group and US group.
CONCLUSION: ES is a safe and feasible tool as same as US used in laparoscopic TME with
anal
sphincter preservation for rectal cancer on the basis of the skillful laparoscopic technique and the complete understanding of laparoscopic pelvic anatomy.
[MeSH-major]
Digestive System Surgical Procedures / instrumentation. Electrocoagulation / instrumentation. Laparoscopy. Rectal
Neoplasms
/ surgery. Ultrasonography, Interventional / instrumentation
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[Cites]
Surg Today. 2005;35(7):598-602
[
15976960.001
]
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Surg Endosc. 2006 Aug;20(8):1329-31
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Surg Endosc. 2005 Jul;19(7):892-6
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15920688.001
]
(PMID = 18609692.001).
[ISSN]
1007-9327
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
[Publication-country]
China
[Other-IDs]
NLM/ PMC2725347
32.
Matter M, Paroz A, Calmes JM, Suter M, Brunisholz Y, Vuilleumier H, Tempia-Caliera AA, Givel JC:
[Visceral surgery].
Rev Med Suisse
; 2006 Jan 11;2(48):97-100, 103-6
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They involve more specifically endocrine surgery, obesity, ovarian cancer, rectocele and cystic pancreatic
neoplasia
.
New techniques also emerge, such as electrical gastric stimulation for obesity or Stapled Trans
Anal
Rectal Resection (STARR) for anterior rectocele.
Accurate
diagnosis
criteria allow better management of cystic pancreatic
neoplasia
, especially to choose the best treatment of this condition.
[MeSH-minor]
Bariatric Surgery. Endocrine Glands / surgery. Female. Humans. Ovarian
Neoplasms
/ surgery. Pancreatic
Neoplasms
/ surgery. Rectocele / surgery
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(PMID = 16463793.001).
[ISSN]
1660-9379
[Journal-full-title]
Revue médicale suisse
[ISO-abbreviation]
Rev Med Suisse
[Language]
fre
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Switzerland
[Number-of-references]
66
33.
Sato Y, Araki Y, Ogata Y, Shirouzu K:
Physiological study of anal sphincteric resection in an experimental porcine model.
Kurume Med J
; 2008;55(1-2):7-11
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[Title]
Physiological study of
anal
sphincteric resection in an experimental porcine model.
This study was conducted to compare and evaluate the extent of
anal
sphincteric resection and the degree of
anal
dysfunction in sphincter saving operations for lower rectal cancer using experimental porcine models.
The
anal
maximum resting pressure (AMRP) decreased from 45.1 cmH(2)O in the control group to 14.8, 14.3 and 11.1 cmH(2)O one month after surgery, and to 15.2, 8.8 and 5.2 cmH(2)O three months after surgery, in the ISR, ESR-25% and ESR-50% groups, respectively.
The
anal
maximum squeezing pressure (AMSP) decreased from 81.7 cmH(2)O in the control group to 42.1, 40.1 and 41.1 cmH(2)O one month after surgery in the ISR, ESR-25% and ESR-50% groups, respectively.
Three months after surgery, the potential ratio of EMG was increased almost to the preoperative level both in the ISR and ESR-25% groups, but the ratio of the potential difference in the ESR-50% group with redness, sore and soiling around
anus
was 0.19 and significantly lower compared with other groups.
The results of this study indicate that porcine models with additional resection of less than one quarter of the external
anal
sphincter have little
anal
dysfunction.
[MeSH-major]
Anal
Canal / physiology.
Anal
Canal / surgery
[MeSH-minor]
Animals. Defecation. Digestive System Surgical Procedures. Electromyography. Humans. Models, Animal. Rectal
Neoplasms
/ physiopathology. Rectal
Neoplasms
/ surgery. Swine. Swine, Miniature
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(PMID = 18981679.001).
[ISSN]
1881-2090
[Journal-full-title]
The Kurume medical journal
[ISO-abbreviation]
Kurume Med J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
34.
Lin GL, Qiu HZ, Xiao Y, Wu B, Meng WC:
[Transanal endoscopic microsurgery for rectal intraepithelial neoplasia and early rectal carcinoma].
Zhonghua Wei Chang Wai Ke Za Zhi
; 2008 Jan;11(1):39-43
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[Title]
[Transanal endoscopic microsurgery for rectal intraepithelial
neoplasia and
early rectal carcinoma].
OBJECTIVE: To investigate the clinical value of transanal endoscopic microsurgery (TEM) for rectal intraepithelial
neoplasia
(IN) and early rectal carcinoma.
METHODS: Fifteen patients with rectal
tumor
were selected to undergo local excision by TEM.
The pre-operative
diagnosis
by biopsy and endoanal ultrasonography (EUS): rectal low-grade IN in 8 cases, high-grade IN in 4 and early rectal carcinoma in 3.
The average distance
of tumors
from the
anal
verge was 7.2(4-15) cm.
The average
tumor
size was 1.8(1-4) cm.
RESULTS: All the 15 rectal
tumors
were achieved complete excision (submucosal excision in 5, full-thickness excision in 10), and all the resection margins were clear.
The post-operative pathological
diagnosis
: rectal low-grade IN in 5 cases, high-grade IN in 6, early submucous invasive carcinoma (pT(1)) in 2, advanced carcinoma (pT(2)) in 2.
The diagnostic accuracy of EUS in assessing invasive depth of rectal
tumor
was 86.7% (13/15).
CONCLUSION: TEM is an ideal minimally invasive procedure for the treatment of rectal IN and early rectal carcinoma, with excellent exposure and accurate excision, providing a high-quality
tumor
specimen for pathological staging.
[MeSH-major]
Anal
Canal / surgery. Microsurgery. Rectal
Neoplasms
/ surgery. Rectum / surgery
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(PMID = 18197492.001).
[ISSN]
1671-0274
[Journal-full-title]
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
[ISO-abbreviation]
Zhonghua Wei Chang Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Evaluation Studies; Journal Article
[Publication-country]
China
35.
Petersen S, Jongen J, Petersen C, Sailer M:
Radiation-induced sequelae affecting the continence organ: incidence, pathogenesis, and treatment.
Dis Colon Rectum
; 2007 Sep;50(9):1466-74
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The mechanism that causes incontinence are changes in
anal
resting tone, squeeze pressure, and rectal volume or rectal compliance.
[MeSH-major]
Catheterization / methods. Colorectal
Neoplasms
/ radiotherapy. Fecal Incontinence. Hyperbaric Oxygenation / methods. Laser Therapy / methods. Radiation Injuries / complications
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(PMID = 17661143.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
60
36.
Watson AJ, Smith BB, Whitehead MR, Sykes PH, Frizelle FA:
Malignant progression of anal intra-epithelial neoplasia.
ANZ J Surg
; 2006 Aug;76(8):715-7
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[Title]
Malignant
progression of
anal
intra-epithelial
neoplasia
.
BACKGROUND:
Anal
intra-epithelial
neoplasia
(AIN) is believed to be a precursor to squamous cell carcinoma of the
anus
.
The risk of developing
anal
cancer in patients with AIN, although known to occur, has been thought to be relatively low.
[MeSH-major]
Anus
Neoplasms
/ epidemiology.
Anus
Neoplasms
/ pathology. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / epidemiology
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged.
Neoplasm
Invasiveness. Retrospective Studies. Risk Factors. Treatment Outcome
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(PMID = 16916390.001).
[ISSN]
1445-1433
[Journal-full-title]
ANZ journal of surgery
[ISO-abbreviation]
ANZ J Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Australia
37.
Sugita A, Kimura H, Arai K, Koganei K, Shimada H, Kitoh F, Fukushima T:
[Surgical treatment for ulcerative colitis--recent advances].
Nihon Rinsho
; 2005 May;63(5):859-66
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Standard surgical procedure is ileal pouch
anal
anastomosis with rectal mucosal stripping and stapled ileal pouch
anal
anastomosis.
[MeSH-minor]
Colonic
Neoplasms
/ etiology. Humans. Prednisolone / adverse effects. Pyoderma Gangrenosum / etiology. Pyoderma Gangrenosum / therapy. Quality of Life
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PREDNISOLONE
.
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(PMID = 15881182.001).
[ISSN]
0047-1852
[Journal-full-title]
Nihon rinsho. Japanese journal of clinical medicine
[ISO-abbreviation]
Nippon Rinsho
[Language]
jpn
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Japan
[Chemical-registry-number]
9PHQ9Y1OLM / Prednisolone
[Number-of-references]
23
38.
Biancone L, Orlando A, Kohn A, Colombo E, Sostegni R, Angelucci E, Rizzello F, Castiglione F, Benazzato L, Papi C, Meucci G, Riegler G, Petruzziello C, Mocciaro F, Geremia A, Calabrese E, Cottone M, Pallone F:
Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study.
Gut
; 2006 Feb;55(2):228-33
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[Title]
Infliximab and newly diagnosed
neoplasia
in Crohn's
disease
: a multicentre matched pair study.
BACKGROUND AND AIMS: The widespread use of anti-
tumour
necrosis factor alpha antibody (Infliximab) in Crohn's
disease
(CD) raises concerns about a possible cancer risk in the long term.
In a matched pair study, we assessed whether Infliximab is associated with an increased risk
of neoplasia
.
Cases and controls were matched for sex, age (+/-5 years), site of CD, age at
diagnosis
(+/-5 years), immunosuppressant use, and follow up.
New diagnoses
of neoplasia
from April 1999 to October 2004 were recorded.
RESULTS: Among the 404 CD-IFX,
neoplasia
was diagnosed in nine patients (2.22%) while among the 404 CD-C, seven patients developed
neoplasia
(1.73%) (odds ratio 1.33 (95% confidence interval 0.46-3.84); p=0.40).
In the CD-IFX group, there was one cholangiocarcinoma, three breast cancers, one skin cancer, one leukaemia, one laryngeal cancer, and two
anal
carcinomas.
Age at
diagnosis of neoplasia
did not differ between groups (CD-IFX v CD-C: median 50 (range 40-70 years) v 45 (27-72); p=0.50).
CONCLUSION: In our multicentre matched pair study, the frequency of a new
diagnosis of neoplasia
in CD patients treated with Infliximab was comparable with CD patients who had never received Infliximab.
[MeSH-major]
Antibodies, Monoclonal / adverse effects. Crohn
Disease
/ drug therapy. Gastrointestinal Agents / adverse effects.
Neoplasms
/ chemically induced
[MeSH-minor]
Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Epidemiologic Methods. Female. Humans. Infliximab. Male. Middle Aged. Smoking / adverse effects.
Tumor
Necrosis Factor-alpha / antagonists & inhibitors
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.
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[Cites]
N Engl J Med. 2004 Feb 26;350(9):934-6
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14985492.001
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]
(PMID = 16120759.001).
[ISSN]
0017-5749
[Journal-full-title]
Gut
[ISO-abbreviation]
Gut
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Gastrointestinal Agents; 0 / Tumor Necrosis Factor-alpha; B72HH48FLU / Infliximab
[Other-IDs]
NLM/ PMC1856527
39.
Hida J, Yoshifuji T, Okuno K, Matsuzaki T, Uchida T, Ishimaru E, Tokoro T, Yasutomi M, Shiozaki H:
Long-term functional outcome of colonic J-pouch reconstruction after low anterior resection for rectal cancer.
Surg Today
; 2006;36(5):441-9
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RESULTS: Among the patients with an ultralow anastomosis (<or=4 cm from the
anal
verge), those in the J-group had fewer bowel movements during the day and at night, and less urgency, soiling, protective pad use, incontinence, and dissatisfaction with bowel function than those in the S-group.
CONCLUSION: J-pouch reconstruction after low anterior resection creates a better stool reservoir than straight anastomosis, especially when the anastomosis is less than 4 cm from the
anal
verge, resulting in a better quality of life 3 years after rectal cancer resection.
[MeSH-major]
Colonic Pouches. Rectal
Neoplasms
/ surgery
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[ISSN]
0941-1291
[Journal-full-title]
Surgery today
[ISO-abbreviation]
Surg. Today
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Japan
40.
Spizzirri A, Coccetta M, Cirocchi R, La Mura F, Napolitano V, Bravetti M, Giuliani D, De Sol A, Pressi E, Trastulli S, Di Patrizi MS, Avenia N, Sciannameo F:
Synchronous colorectal neoplasias: our experience about laparoscopic-TEM combined treatment.
World J Surg Oncol
; 2010;8:105
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[Title]
Synchronous colorectal
neoplasias
: our experience about laparoscopic-TEM combined treatment.
Synchronous colorectal
neoplasias
are defined as 2 or more primary
tumors
identified in the same patient and at the same time.
The aim of this work is to describe our experience of minimally invasive approach in patients with synchronous colorectal
neoplasias
.Since January 2001 till December 2009, 557 patients underwent colectomy for colorectal cancer at the Department of General and Emergency Surgery of the University of Perugia; 128 were right colon cancers, 195 were left colon cancers while 234 patients were affected by rectal cancers.
We performed 224 laparoscopic colectomies (112 right, 67 left colectomies and 45 anterior resections of rectum), 91 Transanal Endoscopic Microsurgical Excisions (TEM) and 53 Trans
Anal
Excisions (TAE).
In the same observation period 6 patients, 4 males and 2 females, were diagnosed with synchronous colorectal
neoplasias
.
[MeSH-major]
Adenoma / surgery.
Anal
Canal / surgery.
Anus
Neoplasms
/ surgery. Colorectal
Neoplasms
/ surgery.
Neoplasms
, Multiple Primary / surgery
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[ISSN]
1477-7819
[Journal-full-title]
World journal of surgical oncology
[ISO-abbreviation]
World J Surg Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC3224925
41.
Damin DC, Tolfo GC, Rosito MA, Spiro BL, Kliemann LM:
Sentinel lymph node in patients with rectal cancer invading the anal canal.
Tech Coloproctol
; 2010 Jun;14(2):133-9
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[Title]
Sentinel lymph node in patients with rectal cancer invading the
anal
canal.
BACKGROUND: To assess the feasibility of the sentinel lymph node procedure in patients with rectal cancer extending to the
anal
canal.
METHODS: Between January 2005 and April 2008, 15 patients with adenocarcinoma of the rectum with direct invasion of the
anal
canal and no clinical evidence of inguinal involvement were prospectively enrolled in the study.
CONCLUSIONS: The standardized procedure was highly effective in sampling inguinal sentinel nodes in very low rectal cancers, allowing the detection of subclinical metastatic
disease
.
Although this technique can be potentially useful for a subgroup of patients with isolated inguinal metastases, it cannot be routinely recommended for patients with rectal
tumors
invading the
anal
canal at this moment.
[MeSH-major]
Adenocarcinoma / secondary.
Anal
Canal. Inguinal Canal. Rectal
Neoplasms
/ pathology. Sentinel Lymph Node Biopsy
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged.
Neoplasm
Invasiveness.
Neoplasm
Staging. Predictive Value of Tests. Prospective Studies
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[ISSN]
1128-045X
[Journal-full-title]
Techniques in coloproctology
[ISO-abbreviation]
Tech Coloproctol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Italy
42.
Shia J:
An update on tumors of the anal canal.
Arch Pathol Lab Med
; 2010 Nov;134(11):1601-11
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[Title]
An update on
tumors of
the
anal
canal.
CONTEXT: The
anal
canal possesses complex anatomy and histology and gives rise to a variety
of tumor
types.
Challenging issues remain with regard to both the pathologic
diagnosis and
the clinical management of these
tumors
.
OBJECTIVES: To provide an updated overview of the histogenesis, clinical and pathologic characteristics, diagnostic terminology, and relevant clinical management of the various types of
anal
canal
tumors
.
DATA SOURCES: Recent literature on clinical and pathologic characteristics of
anal
canal
tumors
.
CONCLUSIONS: Although most
anal
canal
tumors
are of squamous lineage, a complex variety of other
tumors
also occurs.
Recognition of such diverse
tumor
entities will allow accurate pathologic
diagnosis and
most optimal clinical management.
[MeSH-major]
Adenocarcinoma / pathology.
Anal
Canal / pathology.
Anus
Neoplasms
/ pathology. Carcinoma, Squamous Cell / pathology. Melanoma / pathology
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(PMID = 21043813.001).
[ISSN]
1543-2165
[Journal-full-title]
Archives of pathology & laboratory medicine
[ISO-abbreviation]
Arch. Pathol. Lab. Med.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
43.
Jin HY, Ye H, Wu KL, Zhu Y, Zhang JH, Liu P, Zhang TE, Ding YJ:
[Indications for colonoscopy examination and its disease distribution: a report of 5690 cases].
Zhonghua Wei Chang Wai Ke Za Zhi
; 2006 May;9(3):214-6
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[Title]
[Indications for colonoscopy examination and its
disease
distribution: a report of 5690 cases].
The reasons for colonoscopy included hemafecia (26.9%), atypical abdominal pain (25.8%), diarrhea or increased frequency of stool (11.1%),
anal
tenesmus or discomfort (7.6%), constipation (7.0%),mucous or bloody purulent stool (3.0%), intra-rectal mass or abdominal mass on physical examination (0.9%), re- examination after colonoscopic polypectomy (10.9%), re-examination after operation for colorectal cancer(1.5%), simple health examination (2.2%).
Colonoscope reached the cecum in 97.7% of the cases,and at least one
disease
was found in 2283 cases (40.1%).
Among them,colorectal cancer accounted for 10.3%, colorectal polyps 19.6%, ulcerative colitis 4.3%, and Crohn's
disease
0.5% respectively.
[MeSH-major]
Colonic Diseases /
diagnosis
. Colonoscopy. Colorectal
Neoplasms
/
diagnosis
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Child. Early
Diagnosis
. Female. Humans. Ileocecal Valve. Male. Middle Aged. Young Adult
MedlinePlus Health Information.
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.
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.
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.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 16721680.001).
[ISSN]
1671-0274
[Journal-full-title]
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
[ISO-abbreviation]
Zhonghua Wei Chang Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
44.
Huyghe E, Nohra J, Khedi M, Soulié M, Rischmann P, Bachaud JM, Plante P:
[Severe (RTOG grades 3 or 4) long-term complications of adjuvant radiotherapy after total prostatectomy].
Prog Urol
; 2006 Sep;16(4):457-60
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[Transliterated title]
Complications sévères (grades 3 ou 4 RTOG) a long-terme
de
la radiothérapie adjuvante après prostatectomie totale.
Three patients developed gastrointestinal complications (2 cases of radiation proctitis and 1
anal
stricture).
[MeSH-major]
Postoperative Complications / etiology. Prostatectomy. Prostatic
Neoplasms
/ radiotherapy. Prostatic
Neoplasms
/ surgery. Radiotherapy, Conformal / adverse effects
[MeSH-minor]
Aged. Aged, 80 and over.
Anus
Diseases / etiology. Constriction, Pathologic / etiology. Cystitis / etiology. Humans. Male. Middle Aged. Proctitis / etiology. Radiotherapy / adverse effects. Radiotherapy, Adjuvant / adverse effects. Severity of Illness Index. Time Factors. Urethral Stricture / etiology
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(PMID = 17069039.001).
[ISSN]
1166-7087
[Journal-full-title]
Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
[ISO-abbreviation]
Prog. Urol.
[Language]
fre
[Publication-type]
English Abstract; Journal Article
[Publication-country]
France
45.
Chen LW, Yu BM, Zhang M, Fu J, Fei CS, Shen Y:
[Diagnostic significance and management principles of colorectal intraepithelial neoplasia].
Zhonghua Wai Ke Za Zhi
; 2009 Jul 1;47(13):992-4
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[Title]
[Diagnostic significance and management principles of colorectal intraepithelial
neoplasia
].
OBJECTIVE: To discuss the significance of pathological
diagnosis of
colorectal intraepithelial
neoplasia and
its treatment principles.
METHODS: One hundred and fifty-eight cases with colorectal
tumors
were treated between January 2004 and June 2008, among them 73 cases
of tumors
were diagnosed as low grade intraepithelial
neoplasia and
89
tumors
as high grade intraepithelial
neoplasia
on biopsy.
RESULTS: With postoperative pathological examination, 109 cases (67.3%) were identified as infiltrative adenocarcinoma, among them 80 cases (89.9%) had been diagnosed as high grade intraepithelial
neoplasia and
the other 29 cases (39.7%) had been diagnosed as low grade intraepithelial
neoplasia
before the operation.
CONCLUSIONS: We should pay more attention to
tumors
with a
diagnosis of
intraepithelial
neoplasia
due to its high potential of malignancy.
When the lesion was highly suspected to be
malignant
, and the resection of the
tumor
would save the
anal
sphincter,
the tumor
should be treated with segmental resection.
If
the tumor
could be confirmed as a infiltrating one then a curative resection is the first choice.
[MeSH-major]
Carcinoma in Situ /
diagnosis
. Carcinoma in Situ / surgery. Colorectal
Neoplasms
/ surgery
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(PMID = 19957809.001).
[ISSN]
0529-5815
[Journal-full-title]
Zhonghua wai ke za zhi [Chinese journal of surgery]
[ISO-abbreviation]
Zhonghua Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
46.
Li X, Chen H, Dai J, Gao Y, Ge Z:
Predictive role of capsule endoscopy on the insertion route of double-balloon enteroscopy.
Endoscopy
; 2009 Sep;41(9):762-6
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Based on our previous retrospective evaluation, a cut-off value of 0.6 was adopted, and the oral or
anal
approach was selected when the index was < or = 0.6 or > 0.6, respectively.
[MeSH-major]
Capsule Endoscopy. Endoscopy, Gastrointestinal / methods. Intestinal Diseases /
diagnosis
[MeSH-minor]
Adolescent. Adult. Aged. Humans. Intestinal
Neoplasms
/
diagnosis
. Middle Aged. Young Adult
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[Copyright]
Copyright Georg Thieme Verlag KG Stuttgart. New York.
[CommentIn]
Endoscopy. 2011 Jan;43(1):38-41
[
21108176.001
]
(PMID = 19662592.001).
[ISSN]
1438-8812
[Journal-full-title]
Endoscopy
[ISO-abbreviation]
Endoscopy
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
47.
Pepek JM, Willett CG, Wu QJ, Yoo S, Clough RW, Czito BG:
Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis.
Int J Radiat Oncol Biol Phys
; 2010 Dec 1;78(5):1413-9
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[Title]
Intensity-modulated radiation therapy for
anal
malignancies: a preliminary toxicity
and disease
outcomes analysis.
PURPOSE: Intensity-modulated radiation therapy (IMRT) has the potential to reduce toxicities associated with chemoradiotherapy in the treatment of
anal
cancer.
This study reports the results of using IMRT in the treatment of
anal
cancer.
METHODS AND MATERIALS: Records of patients with
anal
malignancies treated with IMRT at Duke University were reviewed.
RESULTS: Forty-seven patients with
anal
malignancy (89% canal, 11% perianal skin) were treated with IMRT between August 2006 and September 2008.
CONCLUSIONS: IMRT-based chemoradiotherapy for
anal
cancer results in significant reductions in normal tissue dose and acute toxicities versus historic controls treated without IMRT, leading to reduced rates of toxicity-related treatment interruption.
Early
disease
-related outcomes seem encouraging.
IMRT is emerging as a standard therapy for
anal
cancer.
[MeSH-major]
Anus
Neoplasms
/ radiotherapy. Radiotherapy, Intensity-Modulated / adverse effects
[MeSH-minor]
Adenocarcinoma / radiotherapy. Adolescent. Adult. Aged. Aged, 80 and over. Anemia / etiology. Carcinoma, Squamous Cell / radiotherapy. Diarrhea / etiology. Female. Humans. Leukopenia / etiology. Male. Melanoma / radiotherapy. Middle Aged. Neuroendocrine
Tumors
/ radiotherapy. Radiotherapy Dosage. Rhabdomyosarcoma / radiotherapy. Sarcoma / radiotherapy. Thrombocytopenia / etiology. Treatment Outcome. Young Adult
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[Copyright]
Copyright © 2010 Elsevier Inc. All rights reserved.
(PMID = 20231064.001).
[ISSN]
1879-355X
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
48.
Abbas A, Yang G, Fakih M:
Management of anal cancer in 2010. Part 2: current treatment standards and future directions.
Oncology (Williston Park)
; 2010 Apr 30;24(5):417-24
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[Title]
Management of
anal
cancer in 2010. Part 2: current treatment standards and future directions.
The treatment of
anal
squamous cell cancer with definitive chemoradiation is the gold-standard therapy for localized
anal
cancer, primarily because of its sphincter-saving and colostomy-sparing potential.
In the concluding part of this review, we consider the data on chemoradiation with 5-FU/mitomycin vs radiation alone, chemoradiation with 5-FU/mitomycin vs chemoradiation with 5-FU alone, neoadjuvant chemotherapy with cisplatin/5-FU followed by cisplatin/5-FU plus radiation vs mitomycin/5-FU plus radiation, the addition of induction or maintenance chemotherapy to chemoradiation, the effect of overall treatment time on
tumor
control, whether chemotherapy can be eliminated for early-stage
anal
cancer, and the impact of human immunodeficiency virus infection on treatment.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Anus
Neoplasms
/ drug therapy.
Anus
Neoplasms
/ radiotherapy. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy
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.
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consumer health - Anal Cancer
.
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CIS-DIAMINEDICHLOROPLATINUM
.
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MITOMYCIN C
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
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[CommentIn]
Oncology (Williston Park). 2010 Apr 30;24(5):427-30
[
20480742.001
]
[CommentIn]
Oncology (Williston Park). 2010 Apr 30;24(5):424-7
[
20480741.001
]
(PMID = 20480740.001).
[ISSN]
0890-9091
[Journal-full-title]
Oncology (Williston Park, N.Y.)
[ISO-abbreviation]
Oncology (Williston Park, N.Y.)
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
[Number-of-references]
52
49.
Verma R, Zacharaki EI, Ou Y, Cai H, Chawla S, Lee SK, Melhem ER, Wolf R, Davatzikos C:
Multiparametric tissue characterization of brain neoplasms and their recurrence using pattern classification of MR images.
Acad Radiol
; 2008 Aug;15(8):966-77
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[Title]
Multiparametric tissue characterization of brain
neoplasms
and their recurrence using pattern classification of MR images.
RATIONALE AND OBJECTIVES: Treatment of brain
neoplasms
can greatly benefit from better delineation of bulk
neoplasm
boundary and the extent and degree of more subtle neoplastic infiltration.
The purpose of this study is to quantify the multiparametric imaging profile of
neoplasms
by integrating structural MRI and DTI via statistical image analysis methods to potentially capture complex and subtle tissue characteristics that are not obvious from any individual image or parameter.
This is incorporated into a nonlinear pattern classification technique to create a multiparametric probabilistic tissue characterization, which is applied to data from 14 patients with newly diagnosed primary high-grade
neoplasms
who have not received any therapy before imaging.
RESULTS: Preliminary results demonstrate that this multiparametric tissue characterization helps to better differentiate among
neoplasm
, edema, and healthy tissue, and to identify tissue that is likely to progress to
neoplasm
in the future.
CONCLUSION: This approach has potential applications in treatment, aiding computer-assisted surgery by determining the spatial distributions of healthy and neoplastic tissue, as well as in identifying tissue that is relatively more prone to
tumor
recurrence.
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[Cites]
Magn Reson Imaging. 2006 Nov;24(9):1131-42
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(PMID = 18620117.001).
[ISSN]
1076-6332
[Journal-full-title]
Academic radiology
[ISO-abbreviation]
Acad Radiol
[Language]
ENG
[Grant]
United States / NINDS NIH HHS / NS / NS042645-04; United States / NINDS NIH HHS / NS / R01 NS042645-06A2; United States / NINDS NIH HHS / NS / R01 NS042645-04; United States / NINDS NIH HHS / NS / NS042645-06A2; United States / NINDS NIH HHS / NS / R01 NS042645-05; United States / NINDS NIH HHS / NS / R01 NS042645; United States / NINDS NIH HHS / NS / NS042645-05
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
AU0V1LM3JT / Gadolinium
[Other-IDs]
NLM/ NIHMS60430; NLM/ PMC2596598
50.
Mariolis-Sapsakos T, Malamitsi J, Yakoumakis E, Orfanos F:
Is sentinel node mapping useful in anorectal melanoma?
Hell J Nucl Med
; 2008 Jan-Apr;11(1):39-42
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Anorectal melanoma (AM) is a rare
disease and
few guidelines have been established regarding its therapeutic management.
Under rigid proctoscopy the
anal
scar received four submucosal injections of technetium-99m-sulfur nanocolloid of 29.6 MBq each.
[MeSH-major]
Lymph Nodes / pathology. Lymph Nodes / radionuclide imaging. Melanoma / radionuclide imaging. Melanoma / secondary. Rectal
Neoplasms
/ pathology. Rectal
Neoplasms
/ radionuclide imaging. Sentinel Lymph Node Biopsy / methods. Technetium Tc 99m Aggregated Albumin
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(PMID = 18392226.001).
[ISSN]
1790-5427
[Journal-full-title]
Hellenic journal of nuclear medicine
[ISO-abbreviation]
Hell J Nucl Med
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Greece
[Chemical-registry-number]
0 / Radiopharmaceuticals; 0 / Technetium Tc 99m Aggregated Albumin; 0 / technetium Tc 99m nanocolloid
51.
Kovar JL, Volcheck W, Sevick-Muraca E, Simpson MA, Olive DM:
Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models.
Anal Biochem
; 2009 Jan 15;384(2):254-62
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Malignant
neoplasms
exhibit an elevated rate of glycolysis over normal cells.
This characteristic can be exploited for optical imaging
of tumors
in mice.
In all cases,
tumors
were clearly imaged with good signal-to-noise characteristics.
These data indicate that IRDye 800CW 2-DG is a broadly applicable optical imaging agent for in vivo imaging of
neoplasms
in mice.
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[ISSN]
1096-0309
[Journal-full-title]
Analytical biochemistry
[ISO-abbreviation]
Anal. Biochem.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA106584-02; United States / NCI NIH HHS / CA / CA106584-04; United States / NCI NIH HHS / CA / R01 CA106584-03; United States / NCI NIH HHS / CA / CA106584-03; United States / NCI NIH HHS / CA / CA106584-01A1; United States / NCI NIH HHS / CA / R01 CA106584-01A1; United States / NCI NIH HHS / CA / R01 CA106584-02; United States / NCI NIH HHS / CA / R01 CA106584-04; United States / NCI NIH HHS / CA / R01 CA106584
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Fluorescent Dyes; 0 / IRDye 800CW 2-DG; 0 / IRDye800; 0 / Indoles; 9G2MP84A8W / Deoxyglucose
[Other-IDs]
NLM/ NIHMS109324; NLM/ PMC2720560
52.
Tonus C, Neupert G, Glaser HJ, Stienecker K:
[Double balloon enteroscopy. First surgical experience].
Chirurg
; 2008 May;79(5):474-80
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The approach was oral in 75 cases and
anal
in 31.
RESULTS: Complete small intestine inspection could be performed completely orally in seven of 106 examinations; and in most cases a combined oral/
anal
approach was required.
Further findings included diverticulum (6.7%), changes related to Crohn's
disease
(4.0%), small intestinal
tumors
(4.0%), extraluminar disorders (2.6%), stenoses (1.3%), and others (8.0%).
[MeSH-major]
Endoscopes, Gastrointestinal. Gastrointestinal Diseases /
diagnosis
. Gastrointestinal Hemorrhage / etiology. Gastrointestinal
Neoplasms
/
diagnosis
. Intestinal Obstruction / etiology
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over.
Diagnosis
, Differential. Equipment Design. Female. Humans. Male. Middle Aged. Recurrence. Retrospective Studies
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[Cites]
Am J Gastroenterol. 2007 Mar;102(3):527-35
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(PMID = 18209985.001).
[ISSN]
0009-4722
[Journal-full-title]
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
[ISO-abbreviation]
Chirurg
[Language]
ger
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Germany
53.
Funahashi K:
[Current status of sentinel lymph node-based nodal ultrastaging in colorectal cancer].
Nihon Geka Gakkai Zasshi
; 2009 Mar;110(2):73-7
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In a review of the literature, tracer, technique,
tumor
-related factors (location and size
of tumor
, T stage, status of lymph node metastasis), neoadjuvant chemoradiation therapy, and body mass index were important factors in the accurate
diagnosis of
SLNs in colorectal cancer.
However, further prospective multicenter trials are warranted to evaluate the ultimate clinical relevance of SLN
diagnosis
in colorectal cancer including
anal
cancer.
[MeSH-major]
Colorectal
Neoplasms
/ pathology.
Neoplasm
Staging / methods. Sentinel Lymph Node Biopsy
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(PMID = 19348197.001).
[ISSN]
0301-4894
[Journal-full-title]
Nihon Geka Gakkai zasshi
[ISO-abbreviation]
Nihon Geka Gakkai Zasshi
[Language]
jpn
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Japan
[Number-of-references]
26
54.
Khan GN, Siddiqui M, Ben-Josef E, Zalupski MM:
An unusual case of small cell carcinoma of the anal canal.
Am J Clin Oncol
; 2009 Oct;32(5):543-4
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[Title]
An unusual case of small cell carcinoma of the
anal
canal.
[MeSH-major]
Anal
Canal / pathology.
Anus
Neoplasms
/
diagnosis
. Carcinoma, Small Cell /
diagnosis
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(PMID = 23061097.001).
[ISSN]
1537-453X
[Journal-full-title]
American journal of clinical oncology
[ISO-abbreviation]
Am. J. Clin. Oncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
55.
Morton LM, Curtis RE, Linet MS, Bluhm EC, Tucker MA, Caporaso N, Ries LA, Fraumeni JF Jr:
Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype.
J Clin Oncol
; 2010 Nov 20;28(33):4935-44
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Patients with HIV/AIDS-related lymphoma (n = 932) were predominantly diagnosed with DLBCL and had significantly and substantially elevated risks for second
anal
cancer (SIR = 120.50) and Kaposi's sarcoma (SIR = 138.90).
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[Cites]
Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):925-33
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(PMID = 20940199.001).
[ISSN]
1527-7755
[Journal-full-title]
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
[ISO-abbreviation]
J. Clin. Oncol.
[Language]
ENG
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Other-IDs]
NLM/ PMC3020697
56.
Fesneau M, Champeaux-Orange E, Hennequin C:
[Anal cancer].
Cancer Radiother
; 2010 Nov;14 Suppl 1:S120-6
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[Title]
[
Anal
cancer].
[Transliterated title]
Cancer du canal
anal
.
Anal
canal epidermoid carcinomas represent 1.2% of digestive cancers and 6%
of ano
-rectal cancers.
For localized diseases, the treatment is based on radiotherapy with or without chemotherapy (5-FU and cisplatin or mitomycin), according to
tumour and
nodal extension.
The recommended treatment dose is 45 Gy in the
anal
canal, the mesorectum, pararectal lymph nodes, and inguinal lymph nodes.
An additional dose of 15 to 20 Gy is delivered in the initial
tumour
for good responders.
The objective of this work is to summarize the epidemiological and radio-anatomic and prognostic characteristics of this
tumour
.
[MeSH-major]
Anus
Neoplasms
/ radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Radiotherapy Dosage
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[Copyright]
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
(PMID = 21129654.001).
[ISSN]
1769-6658
[Journal-full-title]
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
[ISO-abbreviation]
Cancer Radiother
[Language]
fre
[Publication-type]
English Abstract; Journal Article
[Publication-country]
France
57.
Ramírez-Marrero FA, Smit E, De La Torre-Feliciano T, Pérez-Irizarry J, Miranda S, Cruz M, Figueroa-Vallés NR, Crespo CJ, Nazario CM:
Risk of cancer among Hispanics with AIDS compared with the general population in Puerto Rico: 1987-2003.
P R Health Sci J
; 2010 Sep;29(3):256-64
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RESULTS: A total of 612 cancers were identified after 3 months of AIDS
diagnosis
: 409 (66.7%) AIDS related and 203 (33.1%) non-AIDS related.
Non-AIDS related cancers with higher risk during the HAART availability were: oropharyngeal,
anal
, liver, larynx, eye and orbit, Hodgkin lymphoma, and vaginal.
[MeSH-major]
Acquired Immunodeficiency Syndrome / complications. Hispanic Americans.
Neoplasms
/ epidemiology.
Neoplasms
/ etiology
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.
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consumer health - Hispanic American Health
.
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.
HIV InSite.
treatment guidelines - Human Herpesvirus-8
.
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(PMID = 20799513.001).
[ISSN]
0738-0658
[Journal-full-title]
Puerto Rico health sciences journal
[ISO-abbreviation]
P R Health Sci J
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA096257; United States / NCI NIH HHS / CA / P20 CA096256
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
Puerto Rico
58.
Mell LK, Schomas DA, Salama JK, Devisetty K, Aydogan B, Miller RC, Jani AB, Kindler HL, Mundt AJ, Roeske JC, Chmura SJ:
Association between bone marrow dosimetric parameters and acute hematologic toxicity in anal cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy.
Int J Radiat Oncol Biol Phys
; 2008 Apr 1;70(5):1431-7
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[Title]
Association between bone marrow dosimetric parameters and acute hematologic toxicity in
anal
cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy.
PURPOSE: To test the hypothesis that the volume of pelvic bone marrow (PBM) receiving 10 and 20 Gy or more (PBM-V(10) and PBM-V(20)) is associated with acute hematologic toxicity (HT) in
anal
cancer patients treated with concurrent chemoradiotherapy.
METHODS AND MATERIALS: We analyzed 48 consecutive
anal
cancer patients treated with concurrent chemotherapy and intensity-modulated radiation therapy.
The median radiation dose to gross
tumor and
regional lymph nodes was 50.4 and 45 Gy, respectively.
RESULTS: Twenty patients (42%) had Stage T3-4
disease
; 15 patients (31%) were node positive.
CONCLUSION: This analysis supports the hypothesis that increased low-dose radiation to PBM is associated with acute HT during chemoradiotherapy for
anal
cancer.
Techniques to limit bone marrow irradiation may reduce HT in
anal
cancer patients.
[MeSH-major]
Anus
Neoplasms
/ drug therapy.
Anus
Neoplasms
/ radiotherapy. Bone Marrow / radiation effects
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.
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.
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.
Hazardous Substances Data Bank.
MITOMYCIN C
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
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(PMID = 17996390.001).
[ISSN]
0360-3016
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Journal Article; Validation Studies
[Publication-country]
United States
[Chemical-registry-number]
50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
59.
Gaja F, Trecca A:
[Evaluation of the efficacy of a new graduated anal dilator in the treatment of acute anal fissures].
Chir Ital
; 2007 Jul-Aug;59(4):545-50
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[Title]
[Evaluation of the efficacy of a new graduated
anal
dilator in the treatment of acute
anal
fissures].
[Transliterated title]
Nuovo dilatatore
anale
graduato
per
la terapia della ragade
anale
: studio clinico.
Dilatation of the
anal
sphincter with
anal
dilators for the treatment of acute
anal
fissure is efficacious, economic and safe but not always correctly executed with a negative repercussions on the technical results.
Our study was aimed at comparing the efficacy of new graduated dilator with a progressively graduated diameter, using a standard treatment schedule, or a free schedule in comparison with the use of multiple classic dilators currently available for the resolution of
anal
fissures.
A series of 60 patients, 35 female and 25 male, with a clinical
diagnosis of
acute
anal
fissure in the absence of a hypotonic
anal
sphincter, abscess or perianal fistula, hemorrhoidal thrombosis, chronic inflammatory bowel diseases or lower gastrointestinal
neoplasms
were preliminarily evaluated with the solid sphere test and randomly divided into three groups: the first was treated with the new graduated dilator with a standard treatment schedule (20 patients); the second was treated with multiple
anal
dilators (20, 23, 27 mm) (20 patients) using a standard treatment schedule, and the third group (20 patients) was treated with the new graduated dilator according to a free treatment schedule.
After four weeks of treatment, 91% of all patients showed resolution of the
anal
fissure.
The use of the graduated
anal
dilator according to a free treatment schedule seems to induce lasting resolution of acute
anal
fissures with similar results to those achieved using traditional multiple dilators, while proving better tolerated by the patients.
[MeSH-major]
Dilatation / instrumentation. Fissure in
Ano
/ therapy
[MeSH-minor]
Acute
Disease
. Adult. Female. Humans. Male. Manometry. Middle Aged. Rome. Surveys and Questionnaires. Treatment Outcome
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(PMID = 17966778.001).
[ISSN]
0009-4773
[Journal-full-title]
Chirurgia italiana
[ISO-abbreviation]
Chir Ital
[Language]
ita
[Publication-type]
English Abstract; Journal Article; Multicenter Study; Randomized Controlled Trial
[Publication-country]
Italy
60.
Menkarios C, Azria D, Laliberté B, Moscardo CL, Gourgou S, Lemanski C, Dubois JB, Aillères N, Fenoglietto P:
Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans.
Radiat Oncol
; 2007;2:41
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[Title]
Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced
anal
canal carcinoma: a comparison of conventional and IMRT plans.
BACKGROUND: To compare the dosimetric advantage of three different intensity-modulated radiation therapy (IMRT) plans to a three dimensional (3D) conventional radiation treatment for
anal
cancer with regards to organs-at-risk (OAR) avoidance, including iliac bone marrow.
METHODS: Five patients with T1-3 N0-1
anal
cancer and five with T4 and/or N2-3
tumors
were selected.
Clinical
tumor
volume (CTV) included
tumor
,
anal
canal and inguinal, peri-rectal, and internal/external iliac nodes (plus pre-sacral nodes for T4/N2-3
tumors
).
CONCLUSION: IMRT is superior to 3D conformal radiation treatment for
anal
carcinoma with respect to OAR sparing, including bone marrow sparing.
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Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):354-61
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(PMID = 18005443.001).
[ISSN]
1748-717X
[Journal-full-title]
Radiation oncology (London, England)
[ISO-abbreviation]
Radiat Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2204019
61.
Lanteri R, Aliotta I, Racalbuto A, Licata A:
Anal GIST in older old patient: a case report.
G Chir
; 2005 Apr;26(4):135-7
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[Title]
Anal
GIST in older old patient: a case report.
It is generally difficult to determine if they are to be considered as a
benign
or
malignant
neoplastic
disease
.
We present the case of a patient with recurrence of
anal
GIST who was examined 8 years after the first treatment.
During rectal exploration we found a mass spreading inside the lumen 3 cm from the
anal
verge.
Colonoscopy showed that
the tumour
, which was 7 x 5 cm in size, was inside the wall with normal mucosa.
The patient was discharged 5 days after surgery and is alive; she only showed a small local recurrence
of disease
30 months after treatment.
Histological examination confirmed that
the tumour
was a GIST This case provides the basis for a discussion about characteristics and the evolution of this group of pathologies.
[MeSH-major]
Anus
Neoplasms
/ surgery. Gastrointestinal Stromal
Tumors
/ surgery.
Neoplasm
Recurrence, Local
[MeSH-minor]
Aged. Aged, 80 and over. Female. Humans.
Neoplasm
Staging. Treatment Outcome
Genetic Alliance.
consumer health - Gastrointestinal Stromal Tumors
.
MedlinePlus Health Information.
consumer health - Anal Cancer
.
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(PMID = 16035248.001).
[ISSN]
0391-9005
[Journal-full-title]
Il Giornale di chirurgia
[ISO-abbreviation]
G Chir
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Italy
62.
Van der Kwast TH, Zlotta AR, Fleshner N, Jewett M, Lopez-Beltran A, Montironi R:
Thirty-five years of noninvasive bladder carcinoma: a plea for the use of papillary intraurothelial neoplasia as new terminology.
Anal Quant Cytol Histol
; 2008 Dec;30(6):309-15
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[Title]
Thirty-five years of noninvasive bladder carcinoma: a plea for the use of papillary intraurothelial
neoplasia
as new terminology.
Since the introduction of the World Health Organization (WHO) 1973 terminology for bladder cancer, noninvasive epithelial bladder
tumors
have consistently been labeled bladder carcinomas.
In the WHO 2004 classification the removal of the "carcinoma" label from a small subset of noninvasive bladder carcinomas with indolent behavior created the entity of papillary urothelial
neoplasms
of low
malignant
potential, but the remaining noninvasive carcinomas of the urothelial tract retained this label.
In line with the tendency during the last few decades to label flat precancerous lesions of various organs intraepithelial
neoplasms
, we may now also refer to dysplasia and carcinoma in situ of the urinary tract as low and high grade intraurothelial
neoplasia
, respectively.
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.
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(PMID = 19160695.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
63.
Nonose R, Priolli DG, Cardinalli IA, Máximo FR, Galvão PS, Martinez CA:
Epithelioid hemangioma of the colon: a case report.
Sao Paulo Med J
; 2008 Sep;126(5):294-6
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CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon
benign
vascular
neoplasm
that is usually located on the face or neck.
Neoplasia of
the colon was clinically suspected and she underwent colonoscopy.
This demonstrated the presence of a vegetating sessile lesion of approximately 5 cm in diameter, at a distance of 36 cm from the
anal
margin.
A biopsy collected during the examination suggested a
diagnosis of neoplasia of
vascular origin.
After surgical resection, histopathological examination of the resected specimen confirmed
the diagnosis
of epithelioid hemangioma of the colon, which was backed up by the immunohistochemical panel (factor VIII, Ki-67, CD-34).
Despite the rarity
of neoplasia
of vascular origin, this possibility should be considered in the differential
diagnosis
for colorectal
tumors
.
[MeSH-major]
Angiolymphoid Hyperplasia with Eosinophilia / pathology. Colon / pathology. Hemangioma / pathology. Sigmoid
Neoplasms
/ pathology
[MeSH-minor]
Abdominal Pain. Adult. Colonoscopy.
Diagnosis
, Differential. Female. Humans
Genetic Alliance.
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.
MedlinePlus Health Information.
consumer health - Birthmarks
.
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(PMID = 19099166.001).
[ISSN]
1806-9460
[Journal-full-title]
São Paulo medical journal = Revista paulista de medicina
[ISO-abbreviation]
Sao Paulo Med J
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Brazil
64.
Ohtsuki Y, Watanabe R, Kimura M, Okamoto T, Murakami S, Mizukami Y, Takeji M, Okada Y, Hayashi Y, Lee GH, Furihata M:
Immunohistochemical and electron microscopic studies of a case of duodenal gangliocytic paraganglioma.
Med Mol Morphol
; 2009 Dec;42(4):245-9
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Gangliocytic paraganglioma (GPG) is a rare
tumor
, occurring almost exclusively in the duodenum.
In the present case, a submucosal
tumor
2.5 x 2 x 1.5 cm in size was located on the
anal
side of the papilla of Vater, with clear margins and without capsule on cut-surface examination.
Tumor
cells included three types of cells: ganglion-like cells (GCs), endocrine cells (ECs), and Schwann cells (SCs).
The histogenesis of GPG most likely involves proliferation and differentiation of pluripotent stem cells in the duodenal crypts in the duodenum as a true
tumor
, although it is also possible that the retroperitoneal components of both GCs and SCs proliferate, together with ECs, from ventral primordial tissue of the pancreas in the duodenum.
[MeSH-major]
Duodenal
Neoplasms
. Paraganglioma
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.
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[ISSN]
1860-1499
[Journal-full-title]
Medical molecular morphology
[ISO-abbreviation]
Med Mol Morphol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
65.
Lim JF, Tjandra JJ, Hiscock R, Chao MW, Gibbs P:
Preoperative chemoradiation for rectal cancer causes prolonged pudendal nerve terminal motor latency.
Dis Colon Rectum
; 2006 Jan;49(1):12-9
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Patients who had rectal cancer with a distal margin within 6 cm of the
anal
verge had
the anus
included in the field of radiotherapy (Group A, n = 26).
Patients who had rectal cancer with a distal margin 6 to 12 cm from the
anal
verge had shielding of the
anus
during radiotherapy (Group B, n = 40).
The maximum resting
anal
pressures were unchanged after chemoradiation.
The maximum squeeze
anal
pressures were reduced (mean = 166.5-157.5 mmHg) after chemoradiation.
These 18 patients similarly had a worsened median Wexner continence score (range, 0-3) and maximum squeeze
anal
pressures (mean = 165.5-144 mmHg).
The results obtained were independent
of tumor
response to chemoradiation.
[MeSH-major]
Adenocarcinoma / therapy. Fluorouracil / therapeutic use. Leucovorin / therapeutic use. Motor Neurons. Peripheral Nervous System Diseases / etiology. Rectal
Neoplasms
/ therapy. Rectum / innervation
Genetic Alliance.
consumer health - Rectal Cancer
.
MedlinePlus Health Information.
consumer health - Peripheral Nerve Disorders
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
Hazardous Substances Data Bank.
LEUCOVORIN
.
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(PMID = 16292664.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antimetabolites, Antineoplastic; 12001-76-2 / Vitamin B Complex; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
66.
Atallah S, Albert M, Larach S:
Transanal minimally invasive surgery: a giant leap forward.
Surg Endosc
; 2010 Sep;24(9):2200-5
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We report the clinical application of this technique and present preliminary data that show TAMIS to be an effective tool for resection of both
malignant and benign
lesions of the rectum.
Patients with biopsy-proven
malignant
lesions were required to undergo endorectal ultrasound preoperatively to determine
tumor
stage.
To perform TAMIS, a single-incision laparoscopic surgery port (SILS Port, Covidien) is introduced into the
anal
canal by applying steady manual pressure.
The average distance from the
anal
verge was 9.3 cm and the mean
tumor
diameter confirmed by pathology measured 2.93 cm.
[MeSH-major]
Laparoscopy / methods. Rectal
Neoplasms
/ surgery
[MeSH-minor]
Adult. Aged. Aged, 80 and over.
Anal
Canal. Biopsy. Endosonography. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures.
Neoplasm
Staging. Treatment Outcome
ClinicalTrials.gov.
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.
The Lens.
Cited by Patents in
.
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(PMID = 20174935.001).
[ISSN]
1432-2218
[Journal-full-title]
Surgical endoscopy
[ISO-abbreviation]
Surg Endosc
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
67.
Solaz Moreno E, Vallalta Morales M, Silla Búrdalo G, Cervera Miguel JI, Díaz Beveridge R, Rayón Martín JM:
[Primary melanoma of the rectum: an infrequent neoplasia with an atypical presentation].
Clin Transl Oncol
; 2005 May;7(4):171-3
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[Title]
[Primary melanoma of the rectum: an infrequent
neoplasia
with an atypical presentation].
[Transliterated title]
Melanoma primario
de
recto: una
neoplasia
infrecuente con una forma
de
presentación atípica.
The main clinical presentations are local symptoms such as rectal bleeding,
anal
mass or pain, or a change in bowel habits.
The tumour
is frequently mistaken for
benign
conditions as haemorrhoids or rectal polyps.
Despite this,
the disease
has a very poor prognosis and 10% of patients survive 5 years.
[MeSH-major]
Melanoma /
diagnosis
. Rectal
Neoplasms
/
diagnosis
MedlinePlus Health Information.
consumer health - Melanoma
.
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[Cites]
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Cancer. 1981 Apr 1;47(7):1891-900
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(PMID = 15960927.001).
[ISSN]
1699-048X
[Journal-full-title]
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
[ISO-abbreviation]
Clin Transl Oncol
[Language]
spa
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Italy
68.
Rivoire M, Malerba M, Gandini A:
[Rectal cancer margin].
Bull Cancer
; 2008 Dec;95(12):1177-81
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During previous years surgeons and pathologists have focused mainly on distal longitudinal margin as the main parameter for
anal
conservation.
[MeSH-major]
Rectal
Neoplasms
/ pathology. Rectal
Neoplasms
/ surgery
[MeSH-minor]
Humans. Laparoscopy. Neoadjuvant Therapy.
Neoplasm
Recurrence, Local.
Neoplasm
, Residual. Prognosis. Rectum / pathology. Rectum / surgery
Genetic Alliance.
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.
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(PMID = 19091651.001).
[ISSN]
1769-6917
[Journal-full-title]
Bulletin du cancer
[ISO-abbreviation]
Bull Cancer
[Language]
fre
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
France
[Number-of-references]
48
69.
Assenat E, Thézenas S, Samalin E, Bibeau F, Portales F, Azria D, Quenet F, Rouanet P, Saint Aubert B, Senesse P:
The value of endoscopic rectal ultrasound in predicting the lateral clearance and outcome in patients with lower-third rectal adenocarcinoma.
Endoscopy
; 2007 Apr;39(4):309-13
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BACKGROUND AND STUDY AIMS: The aim of this study was to assess whether preoperative endorectal ultrasound (ERUS) is able to predict histological infiltration of the external
anal
sphincter or the levator ani muscle in patients with a lower-third rectal
neoplasm and
so the possibility of treatment by sphincter-saving surgery.
PATIENTS AND METHODS: Between May 1996 and May 2003, 66 patients with a lower-third rectal
neoplasm
that was staged as uT2 or greater were entered into a prospective evaluation of ERUS.
An abdominoperineal resection was performed mainly when the lower extent of the
tumor
was within 3.5 cm from the
anal
verge (P = 0.011), but no correlation was observed between the lateral clearance determined by ERUS 1 and the histological clearance (P = 0.091).
With regard to the performance of ERUS 2 for predicting histological infiltration of the external
anal
sphincter or the levator ani muscle, the sensitivity was 100%, the negative predictive value was 100%, the specificity was 87%, and the positive predictive value was 53%.
In a multivariate analysis, the histological clearance
and tumor
T stage were statistically correlated with
disease
-free survival (P = 0.035 and P = 0.05, respectively).
[MeSH-major]
Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Endosonography. Rectal
Neoplasms
/ surgery. Rectal
Neoplasms
/ ultrasonography
[MeSH-minor]
Anal
Canal / pathology. Humans. Multivariate Analysis. Neoadjuvant Therapy.
Neoplasm
Invasiveness.
Neoplasm
Staging. Prospective Studies. Sensitivity and Specificity. Treatment Outcome
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(PMID = 17354183.001).
[ISSN]
1438-8812
[Journal-full-title]
Endoscopy
[ISO-abbreviation]
Endoscopy
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
70.
Shiozawa M, Nishimura K, Nonaka T, Yoshii T, Nakayama N, Motohashi O, Takagi S, Nakayama Y, Akaike M:
[Three cases of radiotherapy combined with S-1 and mitomycin C for anal canal squamous cell carcinomas].
Gan To Kagaku Ryoho
; 2010 Dec;37(13):2941-3
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[Title]
[Three cases of radiotherapy combined with S-1 and mitomycin C for
anal
canal squamous cell carcinomas].
We report three cases of
anal
canal squamous cell carcinoma treated with radiotherapy combined with S-1 and mitomycin C(MMC).
These results suggested that this treatment schedule was safe and effective for
anal
canal carcinomas.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Anus
Neoplasms
/ therapy. Carcinoma, Squamous Cell / therapy
[MeSH-minor]
Administration, Oral. Aged.
Anal
Canal. Antibiotics, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / administration & dosage. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Humans. Injections, Intravenous. Middle Aged. Mitomycin / administration & dosage. Radiotherapy Dosage
MedlinePlus Health Information.
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.
Hazardous Substances Data Bank.
MITOMYCIN C
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
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(PMID = 21160276.001).
[ISSN]
0385-0684
[Journal-full-title]
Gan to kagaku ryoho. Cancer & chemotherapy
[ISO-abbreviation]
Gan To Kagaku Ryoho
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Antibiotics, Antineoplastic; 0 / Antimetabolites, Antineoplastic; 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
71.
Mongardini M, Iachetta RP, Cola A, Maturo A, Giofrè M, Custureri F:
[Low rectovaginal fistula treated with platelet-rich plasma (PRP)].
G Chir
; 2009 Nov-Dec;30(11-12):507-9
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The suggested treatments include trans-
anal
access or combined trans-
anal
and vaginal access.
We present the case of a woman with complicated iatrogenic fistula treated by a combined trans-
anal
and vaginal access, interposition of buccal mucosa and opposition of PRP (platelet rich plasma).
[MeSH-minor]
Aged. Brachytherapy / adverse effects. Carcinoma, Endometrioid / radiotherapy. Carcinoma, Endometrioid / surgery. Combined Modality Therapy. Endometrial
Neoplasms
/ radiotherapy. Endometrial
Neoplasms
/ surgery. Female. Gels. Humans. Hysterectomy. Iatrogenic
Disease
. Mouth Mucosa / transplantation. Suture Techniques. Transplantation, Heterotopic. Wound Healing / drug effects
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(PMID = 20109382.001).
[ISSN]
0391-9005
[Journal-full-title]
Il Giornale di chirurgia
[ISO-abbreviation]
G Chir
[Language]
ita
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Italy
[Chemical-registry-number]
0 / Gels
72.
Seo Y, Kinsella MT, Reynolds HL, Chipman G, Remick SC, Kinsella TJ:
Outcomes of chemoradiotherapy with 5-Fluorouracil and mitomycin C for anal cancer in immunocompetent versus immunodeficient patients.
Int J Radiat Oncol Biol Phys
; 2009 Sep 1;75(1):143-9
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[Title]
Outcomes of chemoradiotherapy with 5-Fluorouracil and mitomycin C for
anal
cancer in immunocompetent versus immunodeficient patients.
PURPOSE: Information is limited as to how we should treat invasive
anal
squamous cell carcinoma (SCC) in patients with chronic immunosuppression, since the majority of clinical studies to date have excluded such patients.
The objective of this study is to compare treatment outcomes in immunocompetent (IC) versus immunodeficient (ID) patients with invasive
anal
SCC treated similarly with combined modality therapy.
There were no significant differences in
tumor
size, T stage, N stage, chemotherapy doses, or radiation doses between the two groups.
RESULTS: With a median follow-up of 3.1 years, no differences were found in overall survival,
disease
-specific survival, and colostomy-free survival.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Anus
Neoplasms
/ drug therapy.
Anus
Neoplasms
/ radiotherapy. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Radiotherapy, Conformal
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(PMID = 19203845.001).
[ISSN]
1879-355X
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Comparative Study; Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
73.
Chaturvedi AK, Madeleine MM, Biggar RJ, Engels EA:
Risk of human papillomavirus-associated cancers among persons with AIDS.
J Natl Cancer Inst
; 2009 Aug 19;101(16):1120-30
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BACKGROUND: Although risk of human papillomavirus (HPV)-associated cancers of the
anus
, cervix, oropharynx, penis, vagina, and vulva is increased among persons with AIDS, the etiologic role of immunosuppression is unclear and incidence trends for these cancers over time, particularly after the introduction of highly active antiretroviral therapy in 1996, are not well described.
RESULTS: Among persons with AIDS, we observed statistically significantly elevated risk of all HPV-associated in situ (SIRs ranged from 8.9, 95% CI = 8.0 to 9.9, for cervical cancer to 68.6, 95% CI = 59.7 to 78.4, for
anal
cancer among men) and invasive (SIRs ranged from 1.6, 95% CI = 1.2 to 2.1, for oropharyngeal cancer to 34.6, 95% CI = 30.8 to 38.8, for
anal
cancer among men) cancers.
During 1996-2004, low CD4 T-cell count was associated with statistically significantly increased risk of invasive
anal
cancer among men (relative risk [RR]
per
decline of 100 CD4 T cells
per
cubic millimeter = 1.34, 95% CI = 1.08 to 1.66, P = .006) and non-statistically significantly increased risk of in situ vagina or vulva cancer (RR = 1.52, 95% CI = 0.99 to 2.35, P = .055) and of invasive cervical cancer (RR = 1.32, 95% CI = 0.96 to 1.80, P = .077).
Among men, incidence (
per
100 000 person-years) of in situ and invasive
anal
cancer was statistically significantly higher during 1996-2004 than during 1990-1995 (61% increase for in situ cancers, 18.3 cases vs 29.5 cases, respectively; RR = 1.71, 95% CI = 1.24 to 2.35, P < .001; and 104% increase for invasive cancers, 20.7 cases vs 42.3 cases, respectively; RR = 2.03, 95% CI = 1.54 to 2.68, P < .001).
The increasing incidence for
anal
cancer during 1996-2004 indicates that prolonged survival may be associated with increased risk of certain HPV-associated cancers.
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[CommentIn]
J Natl Cancer Inst. 2009 Aug 19;101(16):1103-5
[
19648509.001
]
(PMID = 19648510.001).
[ISSN]
1460-2105
[Journal-full-title]
Journal of the National Cancer Institute
[ISO-abbreviation]
J. Natl. Cancer Inst.
[Language]
ENG
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2728745
74.
De Toma G, Cavallaro G, Bitonti A, Polistena A, Onesti MG, Scuderi N:
Surgical management of perianal giant condyloma acuminatum (Buschke-Löwenstein tumor). Report of three cases.
Eur Surg Res
; 2006;38(4):418-22
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[Title]
Surgical management of perianal giant condyloma acuminatum (Buschke-Löwenstein
tumor
). Report of three cases.
Giant condyloma acuminatum (GCA) is a slow-growing, large, cauliflower-like
tumor
located in the anogenital region.
This
tumor
has a locally destructive behavior, a high recurrence rate and occasional transformation to squamous cell carcinoma.
There is no general agreement on the choice of treatment for this
tumor
.
Loop colostomy, considered mandatory by several authors in order to minimize wound contamination risk, does not appear to be necessary (except in cases of
anal
canal involvement beyond the dentate line) if a combination of bowel cleansing, non-fiber diet and loperamide can be administered.
[MeSH-major]
Anus
Neoplasms
/ surgery. Condylomata Acuminata / surgery
[MeSH-minor]
Adult. Aged.
Anal
Canal / pathology. Female. Humans. Male. Middle Aged. Skin Transplantation
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(PMID = 16902304.001).
[ISSN]
0014-312X
[Journal-full-title]
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
[ISO-abbreviation]
Eur Surg Res
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Switzerland
75.
Bass G, O'Mahony CA, Smith R, Dennison MS, Goss JA:
Biliary epithelial metastasis of squamous carcinoma of the anus.
Ir J Med Sci
; 2010 Dec;179(4):605-6
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[Title]
Biliary epithelial metastasis of squamous carcinoma of the
anus
.
INTRODUCTION: The liver and biliary tree are common sites of initial metastasis for many primary
tumors
.
However, we recently encountered a patient who presented with biliary-tree
tumor
encasement as a first metastasis from squamous carcinoma of the
anus
.
CONCLUSIONS: As obstructive jaundice is a relatively common presenting sign in the emergency room and in general surgical clinics, we thus recommend early consideration of metastatic
disease
as a differential
diagnosis
in patients post-chemoradiotherapy for
anal
carcinoma who present with obstructive jaundice.
[MeSH-major]
Anus
Neoplasms
/ pathology. Biliary Tract
Neoplasms
/ secondary. Carcinoma, Squamous Cell / secondary
[MeSH-minor]
Bile Ducts / pathology. Common Bile Duct
Neoplasms
. Dilatation, Pathologic. Epithelium / pathology. Female. Humans. Jaundice, Obstructive / etiology. Jejunostomy. Middle Aged. Pancreatic Ducts / pathology
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Hepatogastroenterology. 2002 Jan-Feb;49(43):100-3
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(PMID = 20734157.001).
[ISSN]
1863-4362
[Journal-full-title]
Irish journal of medical science
[ISO-abbreviation]
Ir J Med Sci
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Ireland
76.
Canda AE, Terzi C, Gorken IB, Oztop I, Sokmen S, Fuzun M:
Effects of preoperative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patients.
Int J Colorectal Dis
; 2010 Feb;25(2):197-204
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[Title]
Effects of preoperative chemoradiotherapy on
anal
sphincter functions and quality of life in rectal cancer patients.
Significant reduction in
anal
canal resting pressures and squeeze pressures, Wexner score, and FIQL score were observed immediately after the completion of preoperative chemoradiotherapy.
[MeSH-major]
Anal
Canal / drug effects.
Anal
Canal / radiation effects. Antimetabolites, Antineoplastic / adverse effects. Fecal Incontinence / etiology. Fluorouracil / adverse effects. Quality of Life. Rectal
Neoplasms
/ drug therapy. Rectal
Neoplasms
/ radiotherapy
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Cochrane Database Syst Rev. 2007 Apr 18;(2):CD002102
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17443515.001
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(PMID = 19784660.001).
[ISSN]
1432-1262
[Journal-full-title]
International journal of colorectal disease
[ISO-abbreviation]
Int J Colorectal Dis
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
77.
Bean SM, Meara RS, Vollmer RT, Conner MG, Crowe DR, Novak L, Eltoum IA, Robboy SJ, Chhieng DC:
p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.
J Low Genit Tract Dis
; 2009 Jul;13(3):145-53
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[Title]
p16 Improves interobserver agreement in
diagnosis of
anal
intraepithelial
neoplasia
.
OBJECTIVES: Evaluation of
anal
intraepithelial
neoplasia
(AIN) is subjective.
MATERIALS AND METHODS: Seventy-seven
anal
specimens were retrieved.
Fair agreement was observed using H&E
diagnosis
alone (kappa = 0.38, S = 0.56).
CONCLUSIONS: Interobserver agreement for
diagnosis of
AIN was fair when based solely on H&E preparation. p16 alone improved interobserver agreement and demonstrated superior agreement when compared with H&E, Ki-67, and H&E/p16/Ki-67 combined.
[MeSH-major]
Anus
Neoplasms
/
diagnosis
. Carcinoma in Situ /
diagnosis
. DNA,
Neoplasm
/ analysis. Gene Expression Regulation, Neoplastic. Genes, p16 / physiology
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Antigens,
Neoplasm
/ analysis. Biopsy. Clinical Competence.
Diagnosis
, Differential. Female. Humans. Male. Middle Aged. Observer Variation. Retrospective Studies
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(PMID = 19550211.001).
[ISSN]
1526-0976
[Journal-full-title]
Journal of lower genital tract disease
[ISO-abbreviation]
J Low Genit Tract Dis
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Neoplasm; 0 / DNA, Neoplasm
78.
Hessol NA, Holly EA, Efird JT, Minkoff H, Schowalter K, Darragh TM, Burk RD, Strickler HD, Greenblatt RM, Palefsky JM:
Anal intraepithelial neoplasia in a multisite study of HIV-infected and high-risk HIV-uninfected women.
AIDS
; 2009 Jan 2;23(1):59-70
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[Title]
Anal
intraepithelial
neoplasia
in a multisite study of HIV-infected and high-risk HIV-uninfected women.
OBJECTIVES: To study
anal
intraepithelial
neoplasia and
its associations with
anal
and cervical human papillomavirus (HPV), cervical
neoplasia
, host immune status, and demographic and behavioral risk factors in women with and at risk for HIV infection.
METHODS: In 2001-2003 participants were interviewed, received a gynecological examination,
anal
and cervical cytology testing and, if abnormal, colposcopy-guided or anoscopy-guided biopsy of visible lesions.
Exfoliated cervical and
anal
specimens were assessed for HPV using PCR and type-specific HPV probing.
Logistic regression analyses were performed, and odds ratios (ORs) estimated risks for
anal
intraepithelial
neoplasia
.
Low-grade
anal
intraepithelial
neoplasia
was present in 12% of HIV-infected and 5% of HIV-uninfected women.
High-grade
anal
intraepithelial
neoplasia
was present in 9% of HIV-infected and 1% of HIV-uninfected women.
In adjusted analyses among HIV-infected women, the risk factors for low-grade
anal
intraepithelial
neoplasia
were younger age [OR = 0.59, 95% confidence interval (CI) = 0.36-0.97], history of receptive
anal
intercourse (OR = 3.2, 95% CI = 1.5-6.8),
anal
HPV (oncogenic types only OR = 11, 95% CI = 1.2-103; oncogenic and nononcogenic types OR = 11, 95% CI = 1.3-96), and cervical HPV (oncogenic and nononcogenic types OR = 3.5, 95% CI = 1.1-11).
In multivariable analyses among HIV-infected women, the only significant risk factor for high-grade
anal
intraepithelial
neoplasia
was
anal
HPV infection (oncogenic and nononcogenic types OR = 7.6, 95% CI = 1.5-38).
CONCLUSION: Even in the era of highly active antiviral therapy, the prevalence of
anal
intraepithelial
neoplasia
was 16% in HIV-infected women.
After controlling for potential confounders, several risk factors for low-grade
anal
intraepithelial
neoplasia
differed from risk factors for high-grade
anal
intraepithelial
neoplasia
.
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[Cites]
AIDS. 1999 May 7;13(7):839-43
[
10357384.001
]
[Cites]
J Natl Cancer Inst. 1994 Nov 16;86(22):1711-6
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(PMID = 19050387.001).
[ISSN]
1473-5571
[Journal-full-title]
AIDS (London, England)
[ISO-abbreviation]
AIDS
[Language]
ENG
[Grant]
United States / NIAID NIH HHS / AI / U01-AI-42590; United States / NIAID NIH HHS / AI / U01 AI031834; United States / NCI NIH HHS / CA / R01 CA 88739; United States / NIAID NIH HHS / AI / U01 AI035004; United States / NICHD NIH HHS / HD / U01-HD-32632; United States / NCI NIH HHS / CA / R01 CA088739; United States / NCRR NIH HHS / RR / UL1 RR024131; United States / NIAID NIH HHS / AI / U01 AI034989; United States / NIAID NIH HHS / AI / U01-AI-34994; United States / NIAID NIH HHS / AI / U01-AI-35004; United States / NCI NIH HHS / CA / CA088739-05S1; United States / NIAID NIH HHS / AI / U01-AI-31834; United States / NIAID NIH HHS / AI / U01 AI034994; United States / NIAID NIH HHS / AI / U01 AI034989-15; United States / NCI NIH HHS / CA / R01 CA088739-05S1; United States / NIAID NIH HHS / AI / U01-AI-34993; United States / NCI NIH HHS / CA / R01 CA085178; United States / NIAID NIH HHS / AI / U01 AI034993; United States / NIAID NIH HHS / AI / U01-AI-34989; United States / NICHD NIH HHS / HD / U01 HD032632; United States / NIAID NIH HHS / AI / U01 AI042590
[Publication-type]
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
[Publication-country]
England
[Other-IDs]
NLM/ NIHMS84186; NLM/ PMC2614220
79.
Ptok H, Marusch F, Kuhn R, Gastinger I, Lippert H:
Influence of hospital volume on the frequency of abdominoperineal resection and long-term oncological outcomes in low rectal cancer.
Eur J Surg Oncol
; 2007 Sep;33(7):854-61
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AIM: Studies analysing the outcome after resection of low rectal cancer that has not infiltrated the
anal
sphincter reveal poorer long-term outcomes after abdominoperineal resections (APR) in comparison with low anterior resections (LAR).
RESULTS: Univariate analysis revealed that patients undergoing APR had a higher local recurrence rate (p = 0.022) and shorter
disease
-free survival (p < 0.001) than patients undergoing LAR, while hospital volume showed merely a tendency to impact the local recurrence rate (p = 0.060).
With regard to
disease
-free survival, no dependence on hospital volume was to be found (p = 0.201).
Multivariate analysis revealed an independent impact of hospital volume on local recurrence rate, while
disease
-free survival was influenced by the type of surgical procedure performed.
The type of procedure does not affect the local recurrence rate but
the disease
free survival.
[MeSH-major]
Digestive System Surgical Procedures / statistics & numerical data. Hospitals / statistics & numerical data. Rectal
Neoplasms
/ surgery
[MeSH-minor]
Adult. Aged. Aged, 80 and over.
Anal
Canal / surgery.
Disease
-Free Survival. Female. Follow-Up Studies. Germany / epidemiology. Humans. Incidence. Male. Middle Aged.
Neoplasm
Recurrence, Local / epidemiology. Prospective Studies. Treatment Outcome
Genetic Alliance.
consumer health - Rectal Cancer
.
MedlinePlus Health Information.
consumer health - Health Facilities
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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(PMID = 17933024.001).
[ISSN]
0748-7983
[Journal-full-title]
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
[ISO-abbreviation]
Eur J Surg Oncol
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
England
80.
Wang H, Fu CG, Zheng JM, Gong HF, Tao LY, Yu ED, Zhang W, Liu LJ, Hao LQ, Meng RG:
[Impact of meticulousness of pathologists on lymph node harvest after radical resection of invasive rectal carcinoma].
Zhonghua Wei Chang Wai Ke Za Zhi
; 2009 Nov;12(6):569-72
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Excluded criteria were recurrent colorectal
tumor
, Tis
tumor
, R(1) or R(2) resection,
tumor
resection transanally or endoscopically, the cases enrolled in other prospective research, synchronous diseases affecting the surgical procedure for the rectal cancer (familial adenomatous polyposis, synchronous colorectal carcinoma) and rectal cancer receiving neoadjuvant chemoradiation.
There were no significant differences in gender (46/76 vs 86/156, P=0.436), age (58.1+/-1.3 vs 59.2+/-1.1, P=0.527), distance from
tumor
to
anal
verge (7.4+/-0.4 vs 7.1+/-0.3, P=0.761), proportion of sphincter-sparing surgery (67/76 vs 140/156, P=0.715), ratio of well and moderate differentiated
tumors
(68/76 vs 125/156, P=0.074) and overall TNM stage (P=0.167) between the two groups.
[MeSH-major]
Biopsy. Lymph Node Excision. Lymph Nodes / pathology. Rectal
Neoplasms
/ pathology
[MeSH-minor]
Female. Humans. Male. Middle Aged.
Neoplasm
Staging. Postoperative Period. Rectum / pathology. Retrospective Studies
MedlinePlus Health Information.
consumer health - Biopsy
.
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(PMID = 19921565.001).
[ISSN]
1671-0274
[Journal-full-title]
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
[ISO-abbreviation]
Zhonghua Wei Chang Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
81.
Krand O, Yalti T, Tellioglu G, Kara M, Berber I, Titiz MI:
Use of smooth muscle plasty after intersphincteric rectal resection to replace a partially resected internal anal sphincter: long-term follow-up.
Dis Colon Rectum
; 2009 Nov;52(11):1895-901
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[Title]
Use of smooth muscle plasty after intersphincteric rectal resection to replace a partially resected internal
anal
sphincter: long-term follow-up.
PURPOSE: Patients with very low rectal cancer were treated by intersphincteric rectal resection employing partial internal
anal
sphincter resection.
They then underwent smooth muscle plasty to restore internal
anal
sphincter function.
PATIENTS AND METHODS: Patients were selected if their biopsies revealed well-differentiated or moderately well-differentiated very low rectal
tumors
with distal
tumor
margins that permitted preservation of part of the internal
anal
sphincter.
RESULTS: Forty-seven patients with T2 to T3 very low rectal carcinomas underwent intersphincteric rectal resection and smooth muscle plasty that extended into the
anal
canal.
The five-year overall
and disease
-free survival rates were 85% and 82%, respectively.
Six months, one year, and two years after intersphincteric rectal resection, 80%, 87%, and 89%, respectively, had good continence (Kirwan
I and
II).
CONCLUSION: Providing neodjuvant treatment and preserving at least half of the functional internal
anal
sphincter mass produces acceptable oncological and functional outcomes in patients undergoing intersphincteric rectal resection for very low rectal cancer.
[MeSH-major]
Anal
Canal / surgery. Digestive System Surgical Procedures / methods. Muscle, Smooth / surgery. Rectal
Neoplasms
/ surgery
[MeSH-minor]
Adult. Aged. Biopsy. Female. Follow-Up Studies. Humans. Ileostomy. Male. Middle Aged. Neoadjuvant Therapy.
Neoplasm
Recurrence, Local. Surveys and Questionnaires. Treatment Outcome
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(PMID = 19966639.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
82.
McCourt M, Armitage J, Monson JR:
Rectal cancer.
Surgeon
; 2009 Jun;7(3):162-9
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Oncological cure and overall survival continue to be the