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[Title] Mass-tag technology responding to intracellular signals as a novel assay system for the diagnosis of tumor.

A novel mass spectrometry-based assay system for determining protein kinase activity employing mass-tagged substrate peptide probes was used for the diagnosis of tumors.

The phosphorylation ratio for the reaction of the H-type peptide probe with the tumor tissue lysate (B16 melanoma) was more than three times higher than that of the D type peptide probe with the normal skin tissue lysate.

These results show that the novel assay system for detecting protein kinase activity using mass-tag technology can be a simple and useful means to profile protein kinase activity for cell or tissue lysate samples, and can be applied to the diagnosis of tumors.

[MeSH-major] Melanoma, Experimental / diagnosis. Peptides / chemistry. Protein Kinases / analysis. Skin Neoplasms / diagnosis. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods

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(PMID = 17046276.001).

[ISSN] 1044-0305

[Journal-full-title] Journal of the American Society for Mass Spectrometry

[ISO-abbreviation] J. Am. Soc. Mass Spectrom.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Indoles; 0 / Maleimides; 0 / Peptides; 125313-65-7 / Ro 31-7549; EC 2.7.- / Protein Kinases; EC 2.7.11.13 / Protein Kinase C

   

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RhoA controls changes in cell morphology and invasion associated with cancer phenotypes.

Cell lines derived from melanoma tumors at varying stages revealed that RhoA is selectively activated in cells of metastatic origin.

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(PMID = 19620624.001).

[ISSN] 1535-9484

[Journal-full-title] Molecular & cellular proteomics : MCP

[ISO-abbreviation] Mol. Cell Proteomics

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / P50 CA058187; United States / NCI NIH HHS / CA / F32 CA105796; United States / NCI NIH HHS / CA / R01-CA126240; United States / NIGMS NIH HHS / GM / T32 GM008759; United States / NCI NIH HHS / CA / R01-CA118972; United States / NIGMS NIH HHS / GM / T32-GM008759; United States / NCI NIH HHS / CA / R01 CA118972; United States / NCI NIH HHS / CA / P50-CA058187; United States / NCI NIH HHS / CA / F32 CA112847; United States / NCI NIH HHS / CA / F32-CA112847; United States / NIAID NIH HHS / AI / R01-AI060841; United States / NCI NIH HHS / CA / F32-CA105796; United States / NCI NIH HHS / CA / R01 CA126240; United States / NIAID NIH HHS / AI / R01 AI060841

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 7LP2MPO46S / S-Adenosylmethionine; AE28F7PNPL / Methionine; EC 3.6.5.2 / rhoA GTP-Binding Protein; EC 5.3.1.- / Aldose-Ketose Isomerases; EC 5.3.1.23 / MRDI protein, human

[Other-IDs] NLM/ PMC2758758

   

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[Title] Cell-cell electrofusion: optimization of electric field amplitude and hypotonic treatment for mouse melanoma (B16-F1) and Chinese Hamster ovary (CHO) cells.

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(PMID = 20628737.001).

[ISSN] 1432-1424

[Journal-full-title] The Journal of membrane biology

[ISO-abbreviation] J. Membr. Biol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

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[MeSH-minor] Animals. Cell Line, Tumor. Freeze Drying. Gene Expression Regulation. Hyaluronic Acid / chemistry. Melanoma, Experimental. Mice. Plasmids. Polyethyleneimine / chemistry

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(PMID = 19692196.001).

[ISSN] 1873-264X

[Journal-full-title] Journal of pharmaceutical and biomedical analysis

[ISO-abbreviation] J Pharm Biomed Anal

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 9002-98-6 / Polyethyleneimine; 9004-61-9 / Hyaluronic Acid; 9007-49-2 / DNA

   

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[Title] Radiculopathy due to malignant melanoma in the sacrum with unknown primary site.

Melanoma is an interesting tumor, showing the appearance of metastasis without any trace of its primary lesion.

To report a very rare case of malignant melanoma in the sacrum with unknown primary origin.

The pathological diagnosis was malignant melanoma.

No obvious primary malignant melanoma was detected on the skin surface, on the oral or anal mucosa, or in the fundus oculi.

However the patient died nine months after initial diagnosis.

Malignant melanoma in the sacrum with an unknown primary site, showing S1 radiculopathy is reported for the first time.

The melanoma could have been a metastatic tumor of the sacrum, although the primary site was not detected.

The incidence of primary melanoma is increasing faster than any other cancer.

Thus treatment of patients with spinal metastasis of melanoma is an important challenge for orthopedic surgeons.

[MeSH-major] Melanoma / secondary. Neoplasms, Unknown Primary / pathology. Radiculopathy / etiology. Radiculopathy / pathology. Sacrum / pathology. Spinal Neoplasms / secondary

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(PMID = 18075762.001).

[ISSN] 1432-0932

[Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

[ISO-abbreviation] Eur Spine J

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Germany

[Other-IDs] NLM/ PMC2525896

   

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Brain metastases of malignant melanomas were induced by injecting tumor cells into the carotid artery of mice.

Possible reasons why metastatic cells of malignant melanomas were not identified in FTIR images are discussed.

[MeSH-minor] Animals. Automatic Data Processing. Brain / pathology. Cell Line, Tumor. Cluster Analysis. Female. Humans. Melanoma / pathology. Mice. Mice, Nude. Neoplasm Transplantation. Optical Fibers. Spectroscopy, Fourier Transform Infrared / methods. Transplantation, Heterologous

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(PMID = 17639353.001).

[ISSN] 1618-2642

[Journal-full-title] Analytical and bioanalytical chemistry

[ISO-abbreviation] Anal Bioanal Chem

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Germany

   

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[Title] [Melanoma adrenal metastasis: report of 3 cases and literature review].

OBJECTIVE: To investigate the clinical diagnosis, treatment and prognosis of melanoma adrenal metastasis.

METHODS: A total of 48 cases of malignant melanoma from 1985 to 2007 were reviewed.

And three cases of melanoma adrenal metastasis were analyzed.

Two cases had a history of cutaneous melanoma and another one suffered previously from anal melanoma.

The other two cases underwent complete resection of melanoma metastasis.

When contralateral adrenal metastasis of melanoma was found 6 months later, left adrenalectomy laparoscopically was performed.

CONCLUSION: Melanoma metastasis to adrenal gland is rare and it generally has a poor prognosis.

Patients with adrenal metastases from melanoma, either isolated or with a limited number of additional metastases, may achieve a survival benefit from surgical resection if all visible lesions are removed.

[MeSH-major] Adrenal Gland Neoplasms / secondary. Melanoma / pathology. Skin Neoplasms / pathology

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(PMID = 20646432.001).

[ISSN] 0376-2491

[Journal-full-title] Zhonghua yi xue za zhi

[ISO-abbreviation] Zhonghua Yi Xue Za Zhi

[Language] chi

[Publication-type] Case Reports; English Abstract; Journal Article; Review

[Publication-country] China

[Number-of-references] 8

   

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[Title] Validation of a HLA-A2 tetramer flow cytometric method, IFNgamma real time RT-PCR, and IFNgamma ELISPOT for detection of immunologic response to gp100 and MelanA/MART-1 in melanoma patients.

BACKGROUND: HLA-A2 tetramer flow cytometry, IFNgamma real time RT-PCR and IFNgamma ELISPOT assays are commonly used as surrogate immunological endpoints for cancer immunotherapy.

HLA-A2 (A*0201) tetramer assay specific for gp100209(210M) and MART-126-35(27L), IFNgamma real time RT-PCR and ELISPOT methods were validated using tumor infiltrating lymphocyte cell lines (TIL) isolated from HLA-A2 melanoma patients.

A positive IFNgamma response (by RT-PCR and ELISPOT) to gp100 was demonstrated in PBMC from 3 melanoma patients.

These methods can be applied not only to cancer vaccines but to other therapeutic proteins as part of immunogenicity and safety analyses.

[MeSH-major] Antigens, Neoplasm / immunology. Enzyme-Linked Immunosorbent Assay / methods. Flow Cytometry / methods. HLA-A2 Antigen / immunology. Interferon-gamma / genetics. Melanoma / immunology. Membrane Glycoproteins / immunology. Neoplasm Proteins / immunology. Reverse Transcriptase Polymerase Chain Reaction / methods

[MeSH-minor] Calibration. Cell Line, Tumor. Humans. MART-1 Antigen. Reference Standards. Reproducibility of Results. Sensitivity and Specificity. gp100 Melanoma Antigen

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NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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[Cites] J Exp Med. 1999 Sep 6;190(5):705-15 [10477554.001]

[Cites] J Clin Oncol. 2005 Feb 1;23(4):741-50 [15613700.001]

[Cites] Methods Mol Biol. 2005;302:51-86 [15937345.001]

[Cites] Clin Diagn Lab Immunol. 2000 Mar;7(2):145-54 [10702485.001]

(PMID = 18945350.001).

[ISSN] 1479-5876

[Journal-full-title] Journal of translational medicine

[ISO-abbreviation] J Transl Med

[Language] eng

[Publication-type] Evaluation Studies; Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / HLA-A2 Antigen; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / PMEL protein, human; 0 / gp100 Melanoma Antigen; 82115-62-6 / Interferon-gamma

[Other-IDs] NLM/ PMC2605437

   

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[Title] Melanoma of the anal canal.

[MeSH-major] Anus Neoplasms / pathology. Melanoma / secondary

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[Cites] Chir Ital. 2003 Jul-Aug;55(4):575-80 [12938606.001]

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(PMID = 21120314.001).

[ISSN] 1980-5322

[Journal-full-title] Clinics (São Paulo, Brazil)

[ISO-abbreviation] Clinics (Sao Paulo)

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] Brazil

[Other-IDs] NLM/ PMC2972593

   

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[Title] Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.

To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human metastatic melanoma lines via lentivirus-based shRNAs approximately to the levels detected in normal melanocytes.

C-MYC depletion also resulted in reduction in the amounts of deoxyribonucleoside triphosphates (dNTPs) and inhibition of proliferation. shRNA-mediated suppression of TS, IMPDH2 or PRPS2 resulted in the decrease of dNTP pools and retardation of the cell cycle progression of melanoma cells in a manner similar to that of C-MYC-depletion in those cells.

Reciprocally, concurrent overexpression of cDNAs for TS, IMPDH2 and PRPS2 delayed proliferative arrest caused by inhibition of C-MYC in melanoma cells.

Moreover, all three proteins express at higher levels in cells from several metastatic melanoma lines compared to normal melanocytes.

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[CommentIn] Cell Cycle. 2008 Aug;7(15):2275-6 [18682683.001]

(PMID = 18677108.001).

[ISSN] 1551-4005

[Journal-full-title] Cell cycle (Georgetown, Tex.)

[ISO-abbreviation] Cell Cycle

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA083081; United States / NCI NIH HHS / CA / P30 CA046592; United States / NCI NIH HHS / CA / 5 P30 CA46592; United States / NCI NIH HHS / CA / R01 CA076581; United States / NCI NIH HHS / CA / R01-CA120244-A1; United States / NCI NIH HHS / CA / R01 CA120244

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Nucleotides; 0 / Proto-Oncogene Proteins c-myc; 0 / RNA, Small Interfering; EC 1.1.1.205 / IMP Dehydrogenase; EC 1.1.1.205 / IMPDH2 protein, human; EC 2.1.1.45 / Thymidylate Synthase; EC 2.7.6.1 / Ribose-Phosphate Pyrophosphokinase

[Other-IDs] NLM/ NIHMS486377; NLM/ PMC3744895

   

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[Title] Effect of granulocyte/macrophage colony-stimulating factor on vaccination with an allogeneic whole-cell melanoma vaccine.

We sought to assess the effect of the addition of granulocyte/macrophage colony-stimulating factor (GM-CSF) to vaccination with a melanoma vaccine.

EXPERIMENTAL DESIGN: Ninety-seven patients with resected melanoma (stage II-IV) were enrolled, stratified by stage, and randomized to receive a cellular melanoma vaccine with or without GM-CSF.

The primary endpoint was delayed-type hypersensitivity (DTH) response to melanoma cells.

These immune changes were accompanied by an increase in early melanoma deaths and a trend toward worse survival with GM-CSF.

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(PMID = 19903777.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / P01 CA012582; United States / NCI NIH HHS / CA / R01 CA076489-05; United States / NCI NIH HHS / CA / CA12582; United States / NCI NIH HHS / CA / CA87071; United States / NCI NIH HHS / CA / CA076489-05; United States / NCI NIH HHS / CA / P01 CA012582-35; United States / NCI NIH HHS / CA / K08 CA087071; United States / NCI NIH HHS / CA / CA76489; United States / NCI NIH HHS / CA / R01 CA076489

[Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Cancer Vaccines; 0 / Immunoglobulin G; 0 / Immunoglobulin M; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor

[Other-IDs] NLM/ NIHMS219270; NLM/ PMC2920049

   

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[Title] Late recurrence of malignant melanoma in the duodenum.

Melanoma is a malignancy originating from melanocytes.

The primary melanoma usually occurs on the skin, retina, anal canal or occasionally at other organs such as the esophagus, penis or vagina.

Although melanoma represents about one-third of all metastatic lesions in the gastrointestinal tract, metastasis of melanoma to the GI tract, detected radiologically or endoscopically, is relatively rare.

In most cases of malignant melanoma, recurrence and death occur within 10 years after treatment of the primary lesion.

We herein report a case showing a recurrence 17 years after extirpation of primary malignant melanoma in the foot.

A 65-year-old man, with a history of extirpation of a malignant melanoma in the sole of his foot 17 years before, presented with anorexia and severe anemia, and multiple duodenal tumors were pointed out with upper gastrointestinal endoscopy.

Histologic examination of the endoscopic biopsy specimen revealed proliferation of large polygonal cells with distinct nucleoli, and malignant melanoma was diagnosed immunohistochemically.

[MeSH-major] Duodenal Neoplasms / pathology. Melanoma / pathology. Neoplasm Recurrence, Local / pathology

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(PMID = 19102354.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / CC chemokine receptor 9; 0 / Receptors, CCR

   

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[Title] Cytotoxic activity of Apomine is due to a novel membrane-mediated cytolytic mechanism independent of apoptosis in the A375 human melanoma cell line.

Apomine, a novel bisphosphonate ester, has demonstrated anticancer activity in a variety of cancer cell lines; however, its mechanism of cytotoxicity is not well understood.

Previous work has demonstrated that Apomine induces cell death by activation of caspase-3 in several cancer cell types.

However, we have demonstrated that Apomine induces cell death in the A375 human melanoma cell line through a novel membrane-mediated mechanism that is independent of caspase-3 activation.

Interestingly, Apomine-mediated cell death in the A375 and UACC 3093 human melanoma cell lines is also independent of N-Ras farnesylation, which was a previously described mechanism of action for Apomine in other cancer cell types.

[MeSH-major] Antineoplastic Agents / toxicity. Apoptosis / drug effects. Cell Membrane / drug effects. Diphosphonates / toxicity. Melanoma / drug therapy

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(PMID = 17024575.001).

[ISSN] 0167-6997

[Journal-full-title] Investigational new drugs

[ISO-abbreviation] Invest New Drugs

[Language] eng

[Grant] United States / NCI NIH HHS / CA / CA23074; United States / NCI NIH HHS / CA / CA27502

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA, Neoplasm; 0 / Diphosphonates; 0 / apomine; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspases; EC 3.6.5.2 / ras Proteins; VC2W18DGKR / Thymidine

   

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[Title] Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth.

BACKGROUND: Melanoma is the most deadly form of skin cancer without effective treatment.

In this study we have assessed the therapeutic potential of MTA in melanoma treatment.

METHODS: To investigate the therapeutic potential of MTA we performed in vitro proliferation and viability assays using six different mouse and human melanoma cell lines wild type for RAS and BRAF or harboring different mutations in RAS pathway.

We also have tested its therapeutic capabilities in vivo in a xenograft mouse melanoma model and using variety of molecular techniques and tissue culture we investigated its anti-proliferative and pro-apoptotic properties.

RESULTS: In vitro experiments showed that MTA treatment inhibited melanoma cell proliferation and viability in a dose dependent manner, where BRAF mutant melanoma cell lines appear to be more sensitive.

CONCLUSIONS: MTA inhibits melanoma cell proliferation and in vivo tumor growth particularly in BRAF mutant melanoma cells.

These data reveal a naturally occurring drug potentially useful for melanoma treatment.

[MeSH-major] Adenosine / pharmacology. Antineoplastic Agents / pharmacology. Cell Proliferation / drug effects. Melanoma / drug therapy. Skin Neoplasms / drug therapy. Thionucleosides / pharmacology

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(PMID = 20529342.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Ribosomal Protein S6; 0 / Thionucleosides; 136601-57-5 / Cyclin D1; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Braf protein, mouse; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; K72T3FS567 / Adenosine

[Other-IDs] NLM/ PMC2891639

   

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BACKGROUND: As a result of advances in skin imaging technology and the development of suitable image processing techniques, during the last decade, there has been a significant increase of interest in the computer-aided diagnosis of melanoma.

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[Cites] Skin Res Technol. 2005 Feb;11(1):17-26 [15691255.001]

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[Cites] Melanoma Res. 2006 Apr;16(2):183-90 [16567974.001]

(PMID = 19159382.001).

[ISSN] 1600-0846

[Journal-full-title] Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

[ISO-abbreviation] Skin Res Technol

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R44 CA060294-02A2; United States / NCI NIH HHS / CA / R44 CA101639; United States / NCI NIH HHS / CA / 2R44 CA-101639-02A2

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] England

[Other-IDs] NLM/ NIHMS317765; NLM/ PMC3160669

   

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In vertebrates, it regulates the development of several cell types including melanocytes and has also been shown to play an important role in melanoma.

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[Cites] Methods Mol Biol. 2000;132:365-86 [10547847.001]

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(PMID = 19635938.001).

[ISSN] 1943-2631

[Journal-full-title] Genetics

[ISO-abbreviation] Genetics

[Language] ENG

[Grant] United States / Intramural NIH HHS / /

[Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Microphthalmia-Associated Transcription Factor; 452VLY9402 / Serine

[Other-IDs] NLM/ PMC2766318

   

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The analysis of tyrosinase activity is important for detecting melanoma cells and Parkinson disease.

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(PMID = 15762558.001).

[ISSN] 0003-2700

[Journal-full-title] Analytical chemistry

[ISO-abbreviation] Anal. Chem.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 46627O600J / Levodopa; 7440-57-5 / Gold; EC 1.14.18.1 / Monophenol Monooxygenase; VTD58H1Z2X / Dopamine; X4W3ENH1CV / Norepinephrine; YKH834O4BH / Epinephrine

   

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[Title] Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines.

In vitro cytotoxicity experiments verified that the Co(2+)-substituted human Arg I displays an approximately 12- to 15-fold lower IC(50) value for the killing of human hepatocellular carcinoma and melanoma cell lines and thus constitutes a promising new candidate for the treatment of l-Arg auxotrophic tumors.

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[ErratumIn] ACS Chem Biol. 2010 Aug 20;5(8):797

(PMID = 20050660.001).

[ISSN] 1554-8937

[Journal-full-title] ACS chemical biology

[ISO-abbreviation] ACS Chem. Biol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA 139059; United States / NCI NIH HHS / CA / R01 CA139059; United States / NCI NIH HHS / CA / CA139059-01; United States / NIBIB NIH HHS / EB / P30 EB009998; United States / NCI NIH HHS / CA / R01 CA139059-01

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 3G0H8C9362 / Cobalt; 42Z2K6ZL8P / Manganese; EC 3.5.3.1 / Arginase

[Other-IDs] NLM/ NIHMS170379; NLM/ PMC2842482

   

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Cutaneous malignant melanoma is considered one of the most deadly human cancers, based on both its penchant for metastatic spread and its typical resistance to currently available therapy.

NRAS and BRAF mutations are rarely found in the same melanoma, suggesting that they may possess important overlapping oncogenic activities.

More surprisingly, we discovered that constitutive RalGEF activation had a major impact on several malignant phenotypes, particularly anchorage-independent growth, indicating that this often overlooked pathway should be more carefully evaluated as a possible therapeutic target.

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[ErratumIn] Oncogene. 2011 Apr 14;30(15):1850

(PMID = 20118982.001).

[ISSN] 1476-5594

[Journal-full-title] Oncogene

[ISO-abbreviation] Oncogene

[Language] ENG

[Grant] United States / Intramural NIH HHS / / ZIA BC008756-22; United States / Intramural NIH HHS / / ZIA BC008756-23; United States / Intramural NIH HHS / / Z99 CA999999; United Kingdom / Wellcome Trust / / 078327; United States / NCI NIH HHS / CA / N01CO12400; United States / NCI NIH HHS / CO / N01-CO-12400

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / ral Guanine Nucleotide Exchange Factor; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Braf protein, mouse; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 2.7.11.1 / Proto-Oncogene Proteins c-raf; EC 3.1.3.67 / PTEN Phosphohydrolase

[Other-IDs] NLM/ NIHMS357536; NLM/ PMC3287039

   

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[Title] Melanoma of the anus disguised as hemorrhoids: surgical management illustrated by a case report.

[MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / surgery. Hemorrhoids / diagnosis. Melanoma / diagnosis. Melanoma / surgery

[MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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(PMID = 17415639.001).

[ISSN] 0163-2116

[Journal-full-title] Digestive diseases and sciences

[ISO-abbreviation] Dig. Dis. Sci.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC1914244

   

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[Title] Galectin-3 expression correlates with apoptosis of tumor-associated lymphocytes in human melanoma biopsies.

The immune system recognizes diverse melanoma antigens.

Here, we have investigated 33 biopsies (eight primary and 25 metastases) from 24 melanoma patients (15-72 years old) and describe the correlation between the expression of galectin-3 or galectin-1 and the level of apoptosis of tumor-associated lymphocytes using immunohistochemistry and an in situ nick translation assay.

Considering the complex process of cancer immunoediting, various interacting factors must be considered.

[MeSH-major] Biomarkers / analysis. Biopsy. Galectin 1 / metabolism. Galectin 3 / metabolism. Lymphocytes, Tumor-Infiltrating / metabolism. Melanoma / metabolism

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(PMID = 16651632.001).

[ISSN] 0002-9440

[Journal-full-title] The American journal of pathology

[ISO-abbreviation] Am. J. Pathol.

[Language] eng

[Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers; 0 / Galectin 1; 0 / Galectin 3; 0 / LGALS1 protein, human

[Other-IDs] NLM/ PMC1606586

   

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To this end, we implement a memetic algorithm for the problem and demonstrate the effectiveness of the arithmetic-harmonic cut on a number of datasets including a cancer type dataset and a corona virus dataset.

[MeSH-minor] Algorithms. Cell Line, Tumor. Cluster Analysis. Colonic Neoplasms / metabolism. Gene Expression Profiling. Humans. Leukemia / metabolism. Melanoma / metabolism. Models, Statistical. Models, Theoretical

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[Cites] Nat Genet. 2000 Mar;24(3):227-35 [10700174.001]

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[Cites] BMC Bioinformatics. 2003 Sep 20;4:43 [14499005.001]

(PMID = 21151943.001).

[ISSN] 1932-6203

[Journal-full-title] PloS one

[ISO-abbreviation] PLoS ONE

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Other-IDs] NLM/ PMC2997101

   

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METHODS: We have evaluated five real-time ARMS assays: BRAF 1799T>A, [this includes V600E and V600K] and NRAS 182A>G [Q61R] and 181C>A [Q61K] in melanoma, EGFR 2573T>G [L858R], 2235-2249del15 [E746-A750del] in non-small-cell lung cancer, and compared the results to DNA sequencing of the mutation 'hot-spots' in these genes in formalin-fixed paraffin-embedded tumour (FF-PET) DNA.

[MeSH-minor] Carcinoma, Non-Small-Cell Lung / genetics. Clinical Trials, Phase II as Topic. Clinical Trials, Phase III as Topic. Humans. Lung Neoplasms / genetics. Melanoma / genetics. Skin Neoplasms / genetics

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[Cites] Nucleic Acids Res. 1989 Apr 11;17(7):2503-16 [2785681.001]

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(PMID = 20925915.001).

[ISSN] 1756-9966

[Journal-full-title] Journal of experimental & clinical cancer research : CR

[ISO-abbreviation] J. Exp. Clin. Cancer Res.

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / DNA, Neoplasm

[Other-IDs] NLM/ PMC2988723

   

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Samples of isolated DNA and exosome fractions from human ovarian (2008) and melanoma (T289) cancer cell lines were used.

[MeSH-minor] Cell Line, Tumor. Female. Humans. Mass Spectrometry. Melanoma / metabolism. Ovarian Neoplasms / metabolism. Sensitivity and Specificity. Subcellular Fractions

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(PMID = 17286953.001).

[ISSN] 0003-2697

[Journal-full-title] Analytical biochemistry

[ISO-abbreviation] Anal. Biochem.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DNA Adducts; 0 / DNA, Neoplasm; 0 / Organoplatinum Compounds; 49DFR088MY / Platinum; Q20Q21Q62J / Cisplatin

   

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Although melanoma is one of the most aggressive tumours, early detection and a high rate of diagnostic accuracy, followed by timely excision, can allow complete recovery in melanoma patients.

This result is important for screening, as it can inform the decision to excise precociously malignant lesions or to avoid unnecessary removal of benign ones.

[MeSH-major] Fractals. Image Processing, Computer-Assisted / methods. Melanoma / diagnosis. Skin Diseases / diagnosis

[MeSH-minor] Diagnosis, Differential. Humans. Nevus, Pigmented / diagnosis. Nevus, Pigmented / pathology

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[Cites] Mech Ageing Dev. 2001 Sep 15;122(13):1461-75 [11470133.001]

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(PMID = 16255424.001).

[ISSN] 0140-0118

[Journal-full-title] Medical & biological engineering & computing

[ISO-abbreviation] Med Biol Eng Comput

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Wide local excision could be considered as the initial treatment of primary anorectal malignant melanoma.

BACKGROUND: Anorectal malignant melanoma was a rare disease with extremely poor prognosis.

The aim of this study was to explore the clinical characteristic, diagnosis and treatment strategies of anorectal malignant melanoma.

METHODS: The data of 57 patients with anorectal malignant melanoma was collected and retrospectively analyzed.

RESULTS: Rectal bleeding and anal mass were found to be common symptoms of anorectal malignant melanoma.

The preoperative diagnosis rate of anorectal malignant melanoma was 48.6%.

CONCLUSIONS: This study identified no survival advantage to abdominoperineal resection in treatment of anorectal malignant melanoma, and we propose that wide local excision could be considered as the initial treatment of choice.

[MeSH-major] Anus Neoplasms / surgery. Melanoma / surgery

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(PMID = 20367986.001).

[ISSN] 0366-6999

[Journal-full-title] Chinese medical journal

[ISO-abbreviation] Chin. Med. J.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

   

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[Title] Osteopontin expression in normal skin and non-melanoma skin tumors.

Osteopontin (OPN) is an adhesive, matricellular glycoprotein, whose expression is elevated in many types of cancer and has been shown to facilitate tumorigenesis in vivo.

To understand the role of OPN in human skin cancer, this study is designed to determine whether OPN is expressed in premalignant [solar/actinic keratosis (AK)] and in malignant skin lesions such as squamous cell carcinomas (SCC) and basal cell carcinomas (BCC), as well as in normal skin exposed or not exposed to sunlight.

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(PMID = 17938278.001).

[ISSN] 0022-1554

[Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

[ISO-abbreviation] J. Histochem. Cytochem.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA090920; United States / NCI NIH HHS / CA / R01 CA90920

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 106441-73-0 / Osteopontin

[Other-IDs] NLM/ PMC2323122

   

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Other approaches include a polyhemoglobin-fibrinogen that acts as an oxygen carrier with platelet-like activity, and a polyhemoglobin-tyrosinase to retard the growth of a fatal skin cancer, melanoma.

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(PMID = 18565337.001).

[ISSN] 0006-3002

[Journal-full-title] Biochimica et biophysica acta

[ISO-abbreviation] Biochim. Biophys. Acta

[Language] ENG

[Grant] None / None / / 13745; Canada / Canadian Institutes of Health Research / / 13745

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Blood Substitutes; 0 / Cross-Linking Reagents; 0 / Hemoglobins; 0 / Oxyhemoglobins; 0 / polyhemoglobin; 9001-32-5 / Fibrinogen; 9034-51-9 / Hemoglobin A; EC 1.11.1.6 / Catalase; EC 1.15.1.1 / Superoxide Dismutase

[Other-IDs] NLM/ CAMS2513; NLM/ PMC3514548

   

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[Title] Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.

Melanoma and other cancers harbor oncogenic mutations in the protein kinase B-Raf, which leads to constitutive activation and dysregulation of MAP kinase signaling.

In order to elucidate molecular determinants responsible for B-Raf control of cancer phenotypes, we present a method for phosphoprotein profiling, using negative ionization mass spectrometry to detect phosphopeptides based on their fragment ion signature caused by release of PO(3)(-).

Ninety phosphorylation events were regulated by oncogenic B-Raf signaling, based on their responses to treating melanoma cells with MKK1/2 inhibitor.

We investigated MINERVA/FAM129B, a target belonging to a protein family with unknown category and function, and established the importance of this protein and its MAP kinase-dependent phosphorylation in controlling melanoma cell invasion into three-dimensional collagen matrix.

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[CommentIn] Mol Cell. 2009 Apr 24;34(2):139-40 [19394291.001]

(PMID = 19362540.001).

[ISSN] 1097-4164

[Journal-full-title] Molecular cell

[ISO-abbreviation] Mol. Cell

[Language] ENG

[Grant] United States / NCRR NIH HHS / RR / RR021005-01; United States / NIGMS NIH HHS / GM / GM065103-08; United States / NCI NIH HHS / CA / R01-CA126240; United States / NIGMS NIH HHS / GM / T32 GM008759; United States / NCI NIH HHS / CA / R01-CA118972; United States / NIGMS NIH HHS / GM / T32 GM065103-08; United States / NCRR NIH HHS / RR / S10 RR021005-01; United States / NCI NIH HHS / CA / R01 CA118972; United States / NCI NIH HHS / CA / R01 CA118972-02; United States / NCI NIH HHS / CA / R01 CA126240; United States / NCRR NIH HHS / RR / S10 RR021005; United States / NIGMS NIH HHS / GM / T32 GM065103

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Fam129B protein, human; 0 / Phosphoproteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf

[Other-IDs] NLM/ NIHMS111623; NLM/ PMC2735263

   

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Using this tool, individual carbon nanotubes, gold nanorods, and melanoma cells with intrinsic melanin markers were identified in unstained (e.g. sentinel lymph nodes) and conventionally-stained tissues.

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[Copyright] © 2010 International Society for Advancement of Cytometry.

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(PMID = 20949577.001).

[ISSN] 1552-4930

[Journal-full-title] Cytometry. Part A : the journal of the International Society for Analytical Cytology

[ISO-abbreviation] Cytometry A

[Language] ENG

[Grant] United States / NIBIB NIH HHS / EB / R01 EB009230-03; None / None / / R01 EB000873-01A2; United States / NCI NIH HHS / CA / R21 CA139373-01; United States / NIBIB NIH HHS / EB / R01 EB009230-01A1; United States / NIBIB NIH HHS / EB / R01 EB000873-04; None / None / / R01 EB000873-03; United States / NIBIB NIH HHS / EB / R01 EB000873-01A2; None / None / / R21 CA139373-02; United States / NIBIB NIH HHS / EB / R01 EB009230; None / None / / R01 EB009230-01A1; United States / NCI NIH HHS / CA / R01 CA131164-02; None / None / / R01 EB000873-04; United States / NIBIB NIH HHS / EB / R01 EB000873-02; United States / NIBIB NIH HHS / EB / R01 EB000873-03; None / None / / R01 CA131164-02; None / None / / R01 EB009230-03; United States / NCI NIH HHS / CA / R01 CA131164-04; None / None / / R01 EB009230-02; United States / NCI NIH HHS / CA / R01 CA131164-03; None / None / / R21 CA139373-01; United States / NCI NIH HHS / CA / R01CA131164; United States / NIBIB NIH HHS / EB / R01EB009230; None / None / / R01 CA131164-03; United States / NIBIB NIH HHS / EB / R01EB000873; United States / NIBIB NIH HHS / EB / R01 EB000873; United States / NCI NIH HHS / CA / R01 CA131164-01A2; None / None / / R01 EB000873-02; None / None / / R01 CA131164-01A2; United States / NCI NIH HHS / CA / R21 CA139373-02; United States / NIBIB NIH HHS / EB / R01 EB009230-02; United States / NCI NIH HHS / CA / R01 CA131164; None / None / / R01 CA131164-04; United States / NCI NIH HHS / CA / R21 CA139373; United States / NCI NIH HHS / CA / R21CA139373

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Melanins; 0 / Nanotubes, Carbon; 7440-57-5 / Gold

[Other-IDs] NLM/ NIHMS268710; NLM/ PMC3339495

   

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[Title] Chemosorption of radiometals of interest to nuclear medicine by synthetic melanins.

INTRODUCTION: Melanins are high-molecular-weight pigments that are ubiquitous in nature and can also be synthesized in the laboratory from a variety of precursors.

Melanins possess numerous interesting physicochemical characteristics, including electromagnetic radiation absorption properties and ability to chelate metals.

We have recently reported that melanin has remarkable ionizing-radiation-shielding properties, possibly because it can interact with photons via Compton scattering.

We hypothesized that, if administered internally, melanin could play a beneficial role by scavenging various radionuclides, in addition to radiation shielding.

METHODS: Three melanins were synthesized from dopamine, 3,4-dihydroxyphenylalanine (l-Dopa) and a combination of l-cysteine and l-Dopa.

For control, synthetic melanin made from tyrosine polymerization (Sigma) was used.

Melanins were characterized by elemental analysis.

The chemosorption of 111In, 225Ac and 213Bi by melanins was studied at 37 degrees C for up to 48 h.

RESULTS: The C-to-N molar ratios for dopamine, l-Dopa and tyrosine melanins were very close at 7.92, 8.39 and 8.48, respectively, while in mixed l-cysteine/l-Dopa melanin, that ratio was much lower at 3.63.

This mixed melanin also contained 22.33% sulfur, thus confirming incorporation of S-containing motifs into its structure.

Dopamine, l-Dopa and tyrosine melanins were very similar in their abilities to decrease the activity of 111In, 225Ac and 213Bi and their radioactive daughters in supernatants by >10-fold in comparison with the starting levels, while mixed l-cysteine/l-Dopa melanin was able to chemosorb only 111In.

CONCLUSIONS: We have demonstrated that synthetic melanins made of diverse precursors can chemosorb 111In, 213Bi and 225Ac, with dopamine, l-Dopa and tyrosine melanins being the most efficient towards all three of these radionuclides.

Such properties of synthetic melanins can contribute to the development of the novel melanin-based radioprotective materials.

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(PMID = 18355691.001).

[ISSN] 0969-8051

[Journal-full-title] Nuclear medicine and biology

[ISO-abbreviation] Nucl. Med. Biol.

[Language] ENG

[Grant] United States / NIAID NIH HHS / AI / AI52733; United States / NIAID NIH HHS / AI / AI060507-04; United States / NIAID NIH HHS / AI / R01 AI060507-03; United States / NIAID NIH HHS / AI / R01 AI060507-03S1; United States / NIAID NIH HHS / AI / AI60507; United States / NIAID NIH HHS / AI / R01 AI052733; United States / NIAID NIH HHS / AI / R56 AI060507; United States / Howard Hughes Medical Institute / / ; United States / NIAID NIH HHS / AI / AI060507-03S1; United States / NIAID NIH HHS / AI / R01 AI060507; United States / NIAID NIH HHS / AI / AI060507-03; United States / NIAID NIH HHS / AI / R01 AI060507-04

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Indium Radioisotopes; 0 / Melanins; 42HK56048U / Tyrosine; 46627O600J / Levodopa; K848JZ4886 / Cysteine; NIK1K0956U / Actinium; U015TT5I8H / Bismuth; VTD58H1Z2X / Dopamine

[Other-IDs] NLM/ NIHMS47415; NLM/ PMC2516407

   

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[Title] Anatomical and molecular imaging of skin cancer.

Skin cancer is the most common form of cancer types.

It is generally divided into two categories: melanoma (∼ 5%) and nonmelanoma (∼ 95%), which can be further categorized into basal cell carcinoma, squamous cell carcinoma, and some rare skin cancer types.

Biopsy is still the gold standard for skin cancer evaluation in the clinic.

Various anatomical imaging techniques have been used to evaluate different types of skin cancer lesions, including laser scanning confocal microscopy, optical coherence tomography, high-frequency ultrasound, terahertz pulsed imaging, magnetic resonance imaging, and some other recently developed techniques such as photoacoustic microscopy.

However, anatomical imaging alone may not be sufficient in guiding skin cancer diagnosis and therapy.

Over the last decade, various molecular imaging techniques (in particular single photon emission computed tomography and positron emission tomography) have been investigated for skin cancer imaging.

The pathways or molecular targets that have been studied include glucose metabolism, integrin α(v)β(3), melanocortin-1 receptor, high molecular weight melanoma-associated antigen, and several other molecular markers.

It is likely that this situation will change in the near future and molecular imaging will truly play an important role in personalized medicine of melanoma patients.

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(PMID = 21437135.001).

[ISSN] 1178-7015

[Journal-full-title] Clinical, cosmetic and investigational dermatology

[ISO-abbreviation] Clin Cosmet Investig Dermatol

[Language] eng

[Publication-type] Journal Article

[Publication-country] New Zealand

[Other-IDs] NLM/ PMC3048596

[Keywords] NOTNLM ; anatomical imaging / antibody / melanoma / molecular imaging / positron emission tomography / skin cancer