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1
anal intraepithelial neoplasia i diagnosis 2005:2010[pubdate] *count=100
167 results
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Items 1 to 100 of about 167
1.
Ho KS, Cranston RD:
Anal cytology screening in HIV-positive men who have sex with men: what's new and what's now?
Curr Opin Infect Dis
; 2010 Feb;23(1):21-5
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[Title]
Anal
cytology screening in HIV-positive men who have sex with men: what's new and what's now?
PURPOSE OF REVIEW: This review will discuss current and future
anal
cytology screening programs to detect
anal
dysplasia in
HIV-positive men who have sex with men (MSM), in addition to other interventions aimed at early detection of
anal
cancer in this population.
RECENT FINDINGS: Evidence of progression from high-grade
anal
dysplasia
to
anal
cancer has been recently demonstrated and strengthens the clinical imperative to
diagnose and
treat this lesion in at-risk populations.
The use of adjunct
molecular
techniques that improve specificity of
anal
cytology screening may have the potential to rationalize current screening referral pathways and focus resources on those at highest risk of progressing to cancer.
Candidate biomarkers that are currently being investigated include protein surrogates of cell cycle deregulation (such as p16ink4a and minichromosomal maintenance proteins), DNA
damage
biomarkers (53BP1) in addition to testing for human papillomavirus genotype, gamma tubulin and beta defensin levels.
SUMMARY:
Anal
cytology, although sensitive for the detection of any
anal
dysplastic abnormality, has poor specificity to detect high-grade
anal
dysplasia
.
As new
molecular
techniques are evolving, the most important immediate clinical intervention is to educate HIV-positive MSM in order to increase awareness of both risk and clinical symptoms suggestive of progression to
anal
cancer.
[MeSH-major]
Anal
Canal
/ pathology.
Anus
Neoplasms / pathology.
Anus
Neoplasms / virology. Early Detection of Cancer / methods. HIV Infections / pathology. Homosexuality, Male
Genetic Alliance.
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(PMID = 19935419.001).
[ISSN]
1473-6527
[Journal-full-title]
Current opinion in infectious diseases
[ISO-abbreviation]
Curr. Opin. Infect. Dis.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
46
2.
González E, Gutiérrez E, Galeano C, Chevia C, de Sequera P, Bernis C, Parra EG, Delgado R, Sanz M, Ortiz M, Goicoechea M, Quereda C, Olea T, Bouarich H, Hernández Y, Segovia B, Praga M, Grupo Madrileño De Nefritis Intersticiales:
Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis.
Kidney Int
; 2008 Apr;73(8):940-6
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The role of steroid treatment in drug-induced acute interstitial nephritis (
DI
-
AIN
) is controversial.
We performed a multicenter retrospective
study
to determine the influence of steroids in 61 patients with biopsy-proven
DI
-
AIN
, 52 of whom were treated with steroids.
The final serum creatinine was significantly
lower in
treated patients while almost half of untreated patients remained on chronic
dialysis
.
After withdrawal of the presumed causative drug, we found that when steroid treatment was delayed (by an average of 34 days) renal function did
not
return to baseline levels compared to those who received steroid treatment within
the first
2 weeks after withdrawal of the offending agent.
Our
study
shows that steroids should be started promptly after
diagnosis
of DI
-
AIN
to avoid subsequent interstitial fibrosis and an incomplete recovery of renal function.
[MeSH-major]
Creatinine /
blood
. Nephritis, Interstitial / drug therapy. Steroids / administration & dosage
MedlinePlus Health Information.
consumer health - Creatinine
.
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[CommentIn]
Nefrologia. 2009;29(2):95-8
[
19396312.001
]
[CommentIn]
Kidney Int. 2008 Oct;74(7):971-2; author reply 972-3
[
18794832.001
]
[CommentIn]
Kidney Int. 2008 Nov;74(10):1360; author reply 1360-1
[
18974767.001
]
[CommentIn]
Nat Clin Pract Nephrol. 2008 Jun;4(6):298-9
[
18398413.001
]
[CommentIn]
Kidney Int. 2008 Apr;73(8):905-7
[
18379525.001
]
(PMID = 18185501.001).
[ISSN]
1523-1755
[Journal-full-title]
Kidney international
[ISO-abbreviation]
Kidney Int.
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
United States
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Steroids; AYI8EX34EU / Creatinine
3.
Velazquez EF, Cubilla AL:
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Anal Quant Cytol Histol
; 2007 Aug;29(4):185-98
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[Title]
Penile
squamous
cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
In developed countries, penile
squamous
cell carcinoma (SCC) account for < 1% of all malignancies in men.
In Paraguay, approximately 30-40 new cases are
diagnosed
per year.
It is important for surgical pathologists to know the anatomy of the penis and possible routes
of tumor
spread because negative resection margins are crucial to avoid local recurrences.
Probable precursor lesions of penile carcinoma include
squamous
hyperplasia, low and high grade
squamous
intraepithelial neoplasia
and lichen sclerosus.
Genetic Alliance.
consumer health - Carcinoma, Squamous Cell
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 17879626.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
43
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4.
Reda SM, Afifi HM, Amine MM:
Primary immunodeficiency diseases in Egyptian children: a single-center study.
J Clin Immunol
; 2009 May;29(3):343-51
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[Title]
Primary
immunodeficiency
diseases in
Egyptian children: a single-center
study
.
INTRODUCTION: Sixty-four
primary
immunodeficiency patients were registered at the Pediatric Allergy and Immunology Department, Children's Hospital,
Ain
Shams University, Cairo, Egypt.
DATA: Predominantly antibody deficiencies were the most common category (35.9%) followed by combined T- and B-cell immunodeficiencies (29.7%), other well defined immunodeficiency syndromes (18.7%), congenital defects of phagocyte
number
, function or both (12.5%),
and diseases
of immune dysregulation (3.1%).
The most frequent
disorder
was common variable immunodeficiency (18.7%).
The mean age at
diagnosis
was 29.9 months.
CONCLUSIONS:
Primary
immunodeficiency disorders are
not
rare in Egyptian children.
It is a prerequisite to establish a national registry
of primary
immunodeficiency in Egypt.
MedlinePlus Health Information.
consumer health - Yeast Infections
.
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16261953.001
]
(PMID = 19002574.001).
[ISSN]
1573-2592
[Journal-full-title]
Journal of clinical immunology
[ISO-abbreviation]
J. Clin. Immunol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
5.
Peng Y, Jiang Y, Chuang ST, Yang XJ:
Computer-aided detection of prostate cancer on tissue sections.
Appl Immunohistochem Mol Morphol
; 2009 Oct;17(5):442-50
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Two sets of color
optical
images were acquired from prostate tissue sections stained with a
double
-chromogen triple-antibody cocktail combining alpha-methylacyl-CoA racemase, p63, and high-
molecular
-weight cytokeratin.
The first
set of images consisted of 20 training images (10 malignant) used for developing the computer technique and 15 test images (7 malignant) used for testing and optimizing the technique.
The computer technique identified image segments of alpha-methylacyl-CoA racemase-labeled malignant
epithelial
cells (red), p63, and high-
molecular
-weight cytokeratin-labeled benign basal cells (brown), and secretory and stromal cells (blue) for identifying prostate cancer automatically.
The sensitivity and specificity of the computer technique were 94% (16/17) and 94% (17/18), respectively, on
the first
(training and test) set of images, and 88% (79/90) and 97% (136/140), respectively, on the second (validation) set of images.
If high-grade prostatic
intraepithelial neoplasia
, which is a precursor of cancer, and atypical cases were included, the sensitivity and specificity were 85% (97/114) and 89% (165/185), respectively.
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[Cites]
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AJR Am J Roentgenol. 2008 Apr;190(4):854-9
[
18356428.001
]
(PMID = 19417626.001).
[ISSN]
1533-4058
[Journal-full-title]
Applied immunohistochemistry & molecular morphology : AIMM
[ISO-abbreviation]
Appl. Immunohistochem. Mol. Morphol.
[Language]
ENG
[Grant]
United States / NIBIB NIH HHS / EB / R21 EB006466; United States / NCI NIH HHS / CA / R21 CA97308; United States / NCI NIH HHS / CA / R21 CA097308-01; United States / NCI NIH HHS / CA / CA097308-02; United States / NCI NIH HHS / CA / R01 CA092361; United States / NCI NIH HHS / CA / CA097308-01; United States / NIBIB NIH HHS / EB / EB006466-02; United States / NIBIB NIH HHS / EB / EB006466-01A1; United States / NIBIB NIH HHS / EB / R21 EB006466-01A1; United States / NIBIB NIH HHS / EB / R21 EB006466-02; United States / NCI NIH HHS / CA / R21 CA097308; United States / NCI NIH HHS / CA / R21 CA097308-02
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Other-IDs]
NLM/ NIHMS100571; NLM/ PMC2836393
6.
Nahas SC, Nahas CS, Silva Filho EV, Levi JE, Atui FC, Marques CF:
Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report.
Sao Paulo Med J
; 2007 Sep 6;125(5):292-4
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[Title]
Perianal squamous
cell carcinoma with high-grade
anal intraepithelial neoplasia
in an HIV-positive
patient
using highly active antiretroviral therapy:
case
report.
CONTEXT: Highly active antiretroviral therapy (HAART) has turned human immunodeficiency virus (HIV) infection into a chronic condition, and this has led to increased incidence of
anal
dysplasia
among HIV-positive patients.
Routine
anal
evaluation including the
anal
canal and perianal
area is recommended for this population, especially for patients infected by oncogenic human papillomavirus (HPV) types.
CASE
REPORT: A 54-year-old homosexual HIV-positive man presented with a six-year history of recurrent
perianal and
anal
warts.
He presented some condylomatous spreading lesions occupying part of the
anal
canal and the perianal
skin, and also a well-demarcated slightly painful
perianal
plaque of dimensions 1.0 x 1.0 cm.
Both
anal
canal
Pap smears and biopsies guided by high-resolution anoscopy revealed high-grade
squamous
intraepithelial
lesion.
Biopsies of the border of the
perianal
plaque also revealed high-grade
squamous
intraepithelial
lesion.
HPV DNA testing of the
anus
detected the presence of HPV-16 type.
The patient
underwent local full-thickness excision of the lesion.
Histological analysis on the excised tissue revealed high-grade
squamous
intraepithelial
lesion with one focus of microinvasive
squamous
cell cancer measuring 1 mm.
The patient
showed pathological evidence of recurrent
anal
and perianal
high-grade
squamous
intraepithelial
lesions at the sixth-month follow-up and required further ablation of those lesions.
However no invasive
squamous
cell carcinoma recurrence has been detected so far.
[MeSH-major]
Antiretroviral Therapy, Highly Active / adverse effects.
Anus
Neoplasms / pathology. Carcinoma,
Squamous
Cell / pathology. HIV Seropositivity / drug therapy. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections / pathology
[MeSH-minor]
Anal
Canal
/ pathology.
Anal
Canal
/ virology. DNA, Viral / analysis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local /
diagnosis
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.
COS Scholar Universe.
author profiles
.
HIV InSite.
treatment guidelines - Non-ARV Adverse Events
.
HIV InSite.
treatment guidelines - Human Herpesvirus-8
.
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.
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(PMID = 18094898.001).
[ISSN]
1516-3180
[Journal-full-title]
São Paulo medical journal = Revista paulista de medicina
[ISO-abbreviation]
Sao Paulo Med J
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Brazil
[Chemical-registry-number]
0 / DNA, Viral
7.
Hefny AF, Eid HO, Al-Bashir M, Abu-Zidan FM:
Blast injuries of large tyres: case series.
Int J Surg
; 2010;8(2):151-4
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[Title]
Blast injuries of large tyres:
case
series.
BACKGROUND: Severe blast injuries of large tyres are similar to those resulting from landmine explosions with neither thermal nor
chemical
effects.
Little has been written about
the destructive
nature of these blasts.
PATIENTS AND METHODS: All patients who had tyre blast injuries and were admitted to Al-
Ain
or Tawam Hospitals between March 2003 and September 2009 were retrospectively studied.
On arrival to the hospital, two patients were unconscious with GCS
of 3
/15.
Three patients had multiple injuries to different
body
parts (43%).
Five patients were admitted to the ICU with a median (range) ICU stay
of 2
(1-2) days.
[MeSH-major]
Blast Injuries / etiology. Motor Vehicles. Multiple Trauma /
diagnosis
. Multiple Trauma / mortality
[MeSH-minor]
Abdominal Injuries /
diagnosis
. Abdominal Injuries / mortality. Abdominal Injuries / therapy. Adult. Air Pressure. Cohort Studies. Combined Modality Therapy. Craniocerebral Trauma /
diagnosis
. Craniocerebral Trauma / mortality. Craniocerebral Trauma / therapy. Explosions. Fracture Fixation / methods. Humans. Injury Severity Score. Male. Middle Aged. Prognosis. Reconstructive Surgical Procedures / methods. Retrospective Studies. Risk Assessment. Surgical Procedures, Operative / methods. Survival Analysis. United Arab Emirates. Wound Healing / physiology
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[Copyright]
Copyright 2009 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
(PMID = 20006742.001).
[ISSN]
1743-9159
[Journal-full-title]
International journal of surgery (London, England)
[ISO-abbreviation]
Int J Surg
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
8.
Gasztonyi B, Pár G, Pár A, Hunyady B:
[Safety of pegylated interferon in patients with hepatitis C virus induced cirrhosis].
Orv Hetil
; 2005 Nov 27;146(48):2431-4
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OBJECTIVES: The authors described their experience with the therapy with pegylated interferon and its safety in patients with hepatitis C virus (HCV) induced liver cirrhosis treated at
First
Department of Medicine, Medical School, University of Pécs and at Tawam Hospital, Al
Ain
, United Arab Emirates.
Liver cirrhosis was
diagnosed
by abdominal ultrasound and/or histological examination of liver biopsy.
RESULTS: Different genotypes of HCV were detected: genotype
1 in
7 cases, genotype
2 in
1 person, genotype
3 in
3 cases.
Thirteen of 24 patients were
not
treated earlier, 6 persons were non-responders to previous interferon monotherapy, pegylated interferon was administered to 5 patients because of relapse.
Biochemical parameters showed improvement in 16 cases (16/24, 66.66%), but did
not in
5 patients.
Temporary
dose
reduction was needed in 13/24 cases (54.16%).
CONCLUSIONS: Pegylated interferon treatment is well tolerated by patients with compensated liver cirrhosis (Child-Pough
stage
A).
Frequent side-effects (half of all cases) were usually mild or moderate requiring discontinuation only
in 2
of 24 patients.
The incidence of neutropenia and thrombocytopenia emphasizes the need of frequent
blood
cell count tests and patients follow up.
[MeSH-minor]
DNA, Viral / isolation & purification. Drug Resistance, Viral. Female. Genotype. Humans. Hungary. Male. Middle Aged. Neutropenia / chemically induced. Polymerase Chain Reaction. Recombinant Proteins. Severity of Illness
Index
. Thrombocytopenia / chemically induced. Treatment Outcome. United Arab Emirates
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(PMID = 16408382.001).
[ISSN]
0030-6002
[Journal-full-title]
Orvosi hetilap
[ISO-abbreviation]
Orv Hetil
[Language]
hun
[Publication-type]
Clinical Trial; English Abstract; Journal Article; Multicenter Study
[Publication-country]
Hungary
[Chemical-registry-number]
0 / Antiviral Agents; 0 / DNA, Viral; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2a; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 76543-88-9 / interferon alfa-2a; 99210-65-8 / interferon alfa-2b
9.
Kreuter A, Jesse M, Potthoff A, Brockmeyer NH, Gambichler T, Stücker M, Bechara FG, Pfister H, Wieland U:
Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men.
J Am Acad Dermatol
; 2010 Sep;63(3):490-8
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[Title]
Expression of proliferative biomarkers in
anal intraepithelial neoplasia
of HIV-positive men.
BACKGROUND:
Anal intraepithelial neoplasia
(
AIN
), a human papillomavirus (HPV)-associated precursor lesion of
anal
carcinoma, is highly prevalent among HIV-infected individuals, especially in men having sex with men (MSM).
Early
diagnosis
and treatment
of AIN
might prevent development of
anal
cancer.
OBJECTIVES: We aimed to evaluate the expression of 8 promising proliferative biomarkers in
anal
dysplasia and
to compare the efficacy of these markers
in diagnosing
high-grade
AIN
.
METHODS: Immunohistochemical analysis of minichromosome maintenance proteins (MCM3, MCM4, MCM6, and MCM7), p21, Ki-67, p16, and proliferating cell
nuclear antigen
(PCNA) was performed in a total of 49 specimens of normal
anal
mucosa and high- and low-grade
anal
dysplasia
.
HPV typing for 36 high- and low-risk HPVs was performed, and high-risk HPV-DNA loads were determined by real-
time
polymerase chain reaction (PCR) for HPV-types 16, 18, 31, and 33.
RESULTS: A total of 392 immunohistochemical slides were analyzed in this
study
.
In the progression from normal epithelium to high-grade
dysplasia
, we found significant differences in the expression of all biomarkers.
A cutoff of 25% or 50% lesional immunopositivity for the 4 MCMs, Ki-67, and p16 resulted in 100% sensitivity and 100% specificity to
diagnose
high-grade
AIN
.
Sensitivity and specificity of PCNA and p21 for a high-grade
AIN
diagnosis
were
lower
.
HPV-DNA was detectable in 100% of high-grade
AIN and
87.5% of low-grade
AIN
lesions.
All MCMs, p16, Ki-67, and PCNA, but
not
p21 correlated with cumulative lesional high-grade HPV-DNA loads.
LIMITATIONS: The relatively small
number of
samples is a limitation, especially for adequate subgroup analyses.
CONCLUSIONS: MCMs, Ki67, and p16 are reliable immunohistochemical adjuncts for
diagnosing
high-grade
AIN
.
[MeSH-major]
Anus
Neoplasms / pathology. Biomarkers,
Tumor
/ analysis. Carcinoma in Situ / pathology. HIV Infections /
diagnosis
. Proliferating Cell
Nuclear Antigen
/ metabolism
[MeSH-minor]
Adult. Aged. Analysis of Variance. Antiretroviral Therapy, Highly Active / methods. Biopsy, Needle. DNA, Viral / analysis. HIV Seropositivity. Homosexuality, Male. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm
Staging
. Papillomavirus Infections / complications. Papillomavirus Infections /
diagnosis
. Polymerase Chain Reaction / methods. Precancerous Conditions / pathology. Reference Values. Risk Assessment. Sensitivity and Specificity. Viral Load. Young Adult
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NCI CPTC Antibody Characterization Program.
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[Copyright]
Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
(PMID = 20006407.001).
[ISSN]
1097-6787
[Journal-full-title]
Journal of the American Academy of Dermatology
[ISO-abbreviation]
J. Am. Acad. Dermatol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / DNA, Viral; 0 / Proliferating Cell Nuclear Antigen
10.
Heselmeyer-Haddad K, Sommerfeld K, White NM, Chaudhri N, Morrison LE, Palanisamy N, Wang ZY, Auer G, Steinberg W, Ried T:
Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.
Am J Pathol
; 2005 Apr;166(4):1229-38
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This provided the rationale for the development of a multicolor fluorescence in situ hybridization (FISH) probe set as a
diagnostic
tool for the direct detection of TERC gains in Pap smears.
We previously used this probe set to show that cervical
intraepithelial neoplasia
(CIN)
2 and
CIN3 lesions could be distinguished from normal samples, atypical
squamous
cell of undetermined significance (ASCUS) and CIN1, with a sensitivity and specificity exceeding 90%, independent of the cytomorphological assessment.
In the current
study
, we explored whether gain of 3q and amplification of TERC could predict progression from CIN1/CIN2 to CIN3 and invasive carcinoma.
Of note, 3q gain was found in 33% of cytologically normal Pap smears from women who were
diagnosed
with CIN3 or invasive cervical carcinoma after a short latency.
[MeSH-major]
Biomarkers,
Tumor
/ analysis. Cervical
Intraepithelial Neoplasia
/ genetics. Cervical
Intraepithelial Neoplasia
/ pathology. RNA / genetics. Telomerase / genetics. Uterine Cervical Neoplasms / genetics. Uterine Cervical Neoplasms / pathology
[MeSH-minor]
Adult.
Disease
Progression. Female. Humans. In Situ Hybridization, Fluorescence. Middle Aged. Papanicolaou Test. Retrospective Studies. Sensitivity and Specificity.
Vaginal
Smears
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.
International Agency for Research on Cancer - Screening Group.
diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas
.
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Cited by Patents in
.
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J Natl Cancer Inst. 2002 Sep 18;94(18):1406-14
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12237286.001
]
(PMID = 15793301.001).
[ISSN]
0002-9440
[Journal-full-title]
The American journal of pathology
[ISO-abbreviation]
Am. J. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / telomerase RNA; 63231-63-0 / RNA; EC 2.7.7.49 / Telomerase
[Other-IDs]
NLM/ PMC1602397
11.
Edgren G, Sparén P:
Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective population-based study.
Lancet Oncol
; 2007 Apr;8(4):311-6
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[Title]
Risk of anogenital cancer after
diagnosis
of cervical
intraepithelial neoplasia
: a prospective population-based
study
.
BACKGROUND:
The first
vaccine against human papillomavirus (HPV)-related
disease
is now available.
Associations between HPV
and vaginal
, vulvar, and
anal
cancers are well established, but the full extent in terms of age
and time
since
diagnosis
of these associations is
not
well known.
Using national registration
numbers
, we linked this cohort to nationwide population, migration, cancer, and death registers.
The incidence rate ratios (IRRs)
of vaginal
, vulvar,
anal
, and rectal cancer in women with a history of a cervical
intraepithelial
neoplasm (CIN), grade 3, compared with women with no such history were estimated by use of multivariate Poisson regression.
FINDINGS: Women with a history of grade 3 CIN had increased risks of cancer of the vagina (6.74 [95% CI 5.24-8.56]), vulva (2.22 [1.79-2.73]),
and anus
(IRR 4.68 [3.87-5.62]).
For all four anatomical sites, the IRRs varied substantially with the amount
of time
that had elapsed since the date
of first
diagnosis
of grade 3 CIN.
Analyses stratified by attained age during follow-up showed that the risk of cancer conferred by a history of
diagnosis
of grade 3 CIN was highly age dependent.
The observed increased risks were
not
explained by smoking or socioeconomic status.
INTERPRETATION
: This
study
confirms the known association between history of CIN, presumed HPV infection, and increased risk of cancers of the vagina, vulva,
and anus
by use of large and complete databases, but also shows that this risk varies both by
the time
from initial
diagnosis
of grade 3 CIN and by the age of the individual.
[MeSH-major]
Anus
Neoplasms / complications. Cervical
Intraepithelial Neoplasia
/ complications. Genital Neoplasms, Female / complications. Uterine Cervical Neoplasms / complications
[MeSH-minor]
Adolescent. Adult. Age Factors. Cohort Studies. Female. Humans. Incidence. Middle Aged. Multivariate Analysis. Prospective Studies. Registries / statistics & numerical data. Regression Analysis. Risk Factors. Sweden / epidemiology.
Time
Factors
Genetic Alliance.
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.
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.
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.
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.
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.
International Agency for Research on Cancer - Screening Group.
diagnostics - A practical manual on visual screening for cervical neoplasia
.
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[CommentIn]
Lancet Oncol. 2007 Apr;8(4):281-2
[
17395100.001
]
(PMID = 17395104.001).
[ISSN]
1470-2045
[Journal-full-title]
The Lancet. Oncology
[ISO-abbreviation]
Lancet Oncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
12.
Health Quality Ontario:
Anal dysplasia screening: an evidence-based analysis.
Ont Health Technol Assess Ser
; 2007;7(4):1-43
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[Title]
Anal
dysplasia
screening: an evidence-based analysis.
OBJECTIVE: This review considered the role of the
anal
Pap test as a screening test for
anal
dysplasia in
patients at high risk of
anal
SCC.
High-resolution anoscopy (a method to view the rectal area, using an anoscope, a lighted instrument inserted into the rectum) rather than routine anoscopy-guided biopsy, is also now considered to be
the diagnostic
standard.
CLINICAL NEED: TARGET POPULATION AND CONDITION
Anal
cancer, like cervical cancer, is a member of a broader
group of
anogenital cancers known to be associated with sexually transmitted viral HPV infection.
Sexual practices involving receptive
anal
intercourse lead to significantly elevated risk for
anal
dysplasia and
cancer, particularly in those with immune dysfunctions.
Anal
cancer is rare.
It is the least common of the
lower
gastrointestinal cancers, representing about 4% of them, in contrast to colorectal cancers, which remain the third most commonly
diagnosed
malignancy.
Certain segments of the population, however, such as HIV-positive men and women, other chronic immune-suppressed patients (e.g., after a transplant), injection drug users, and women with genital
dysplasia
/cancer, have a high susceptibility to
anal
cancer.
Those with the highest identified risk for
anal
cancer are HIV-positive homosexual and bisexual men, at a rate of 70 per 100,000 men.
The risk for
anal
cancer is reported to be increasing dramatically in HIV-positive males and females, particularly since the introduction of highly active antiretroviral therapy in the mid-1990s.
The introduction of effective viral therapy has been said to have transformed the AIDS epidemic in developed countries into a chronic
disease
state of long-term immunosuppression.
About 28% of the newly
diagnosed
HIV infections are in women, a doubling since 1999.
It has also been estimated that
1 of
3 people living with HIV do no know it.
HEALTH TECHNOLOGY DESCRIPTION:
Anal
Pap test screening involves the blind insertion of a swab into the
anal
canal and
fixing cells either on a slide or in fluid for cytological examination.
Anal
cytology classified by the standardized Bethesda System is the same
classification
used for cervical cytology.
It has 4 categories: normal, atypical
squamous
cells of uncertain significance, or
squamous
intraepithelial
lesions which are further classified into low- or high-grade lesions.
Several HPV deoxyribonucleic
acid
detection technologies such as the Hybrid 11 Capture and the polymerase chain reaction are available to detect and differentiate HPV viral strains.
Unlike cervical cancer, there are no universally accepted guidelines or standards of care for
anal
dysplasia
.
The New York State Department of Health AIDS
Institute
has recently recommended (March 2007) annual
anal
pap testing in high-risk groups.
That is, there is no reimbursement for
anal
Pap testing in men or women, and HPV screening tests for cervical or
anal
cancer are also
not
reimbursed.
Assessments of current practices were obtained through consultations with various agencies and individuals including the Ministry of Health and Long-Term Care AIDS Bureau; Public Health Infectious
Diseases
Branch, Ministry of Health and Long-Term Care; Cancer Care Ontario; HIV/AIDS researchers; pathology experts; and HIV/AIDS clinical program directors.
FINDINGS: No direct evidence was found for the existence of controlled studies evaluating the effectiveness of
anal
Pap test screening programs for impact on
anal
cancer morbidity or mortality.
In addition, no studies were found on the use of HPV DNA testing in the screening or
diagnostic
setting for
anal
dysplasia
.
The reported prevalence of HPV infection in high-risk groups, particularly HIV-positive males, however, was sufficiently high to preclude any utility of HPV testing as an adjunct to
anal
Pap testing.
Nine reports involving studies in the United States, United Kingdom, and Canada were identified that evaluated the performance characteristics of
anal
Pap test screening for
anal
dysplasia
.
All studies involved experienced pathologists, so the results generally represent best-
case
scenarios.
Estimates of
anal
Pap test sensitivity and specificity were highly variable, and depended on the varying prevalence of cytology abnormality
and differential
thresholds for abnormality for both cytology and histopathology.
In the largest
study of
HIV-positive males, sensitivity varied from 46% (95% confidence
interval
[CI], 36%-56%) to 69% (95% CI, 60%-78%).
In the only
study of
HIV-negative males, sensitivity ranged from 26% (95% CI, 5%-47%) to 47% (95% CI, 26%-68%).
In comparison, cervical Pap testing has also been evaluated mainly in settings where there is a high prevalence of the
disease
, and estimates of sensitivitykij and specificity were also low and highly variable.
CONCLUSIONS: No direct evidence exists to support the effectiveness of an
anal
Pap test screening program to reduce
anal
cancer mortality or morbidity.
Sexually transmitted HPV viral infection is currently the acknowledged common causative agent for both
anal
and cervical cancer.
Anal
cancer rates in high-risk populations are approaching those of cervical cancer before the implementation of Pap testing.
The
anal
Pap test, although it has been mainly evaluated only in HIV-positive males, has similar operating characteristics of sensitivity and specificity as the cervical Pap test.
In general, the treatment options for precancer
dysplasia in
the cervix and the
anus
are similar, but treatment involving a definitive surgical resection in the
anus
is more limited because of the higher risk of complications.
A range of ablative therapies has been applied for
anal
dysplasia
, but evidence on treatment effectiveness, tolerability and durability, particularly in the HIV-positive
patient
, is limited.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[ISSN]
1915-7398
[Journal-full-title]
Ontario health technology assessment series
[ISO-abbreviation]
Ont Health Technol Assess Ser
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Canada
[Other-IDs]
NLM/ PMC3377578
13.
Adley BP, Yang XJ:
Application of alpha-methylacyl coenzyme A racemase immunohistochemistry in the diagnosis of prostate cancer: a review.
Anal Quant Cytol Histol
; 2006 Feb;28(1):1-13
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[Title]
Application of alpha-methylacyl coenzyme A racemase immunohistochemistry in the
diagnosis
of prostate cancer: a review.
Since its discovery, AMACR has gained wide acceptance for use in the
diagnosis
of prostatic adenocarcinoma in conjunction with morphology and immunohistochemical staining for basal cell markers.
This review focuses on AMACR expression in prostate cancer and its morphologic variants, high grade prostatic
intraepithelial neoplasia
, adenosis and benign conditions of the prostate.
We also focus on the utility and technical aspects of the now-popular "triple stain" immunohistochemical antibody cocktail, consisting of antibodies to high-
molecular
-weight keratin, p63 and AMACR.
Finally, we emphasize
diagnostic
pitfalls in the application of AMACR to small, atypical foci of glands seen on prostate needle core biopsy and project future
diagnostic
as well as clinical applications for the protein.
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(PMID = 16566275.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Evaluation Studies; Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
[Number-of-references]
63
14.
Kreuter A, Wieland U:
Human papillomavirus-associated diseases in HIV-infected men who have sex with men.
Curr Opin Infect Dis
; 2009 Apr;22(2):109-14
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[Title]
Human papillomavirus-associated
diseases in
HIV-infected men who have sex with men.
This review summarizes recent data on papillomavirus-induced
anal intraepithelial neoplasia
and
anal
cancer in these patients.
Moreover, data are provided on penile and oral HPV-associated
diseases
, for which only limited information is available in the literature.
RECENT FINDINGS: The incidence of
anal intraepithelial neoplasia
rises in HIV-positive men who have sex with men despite the introduction of highly active antiretroviral therapy.
Increasing evidence indicates that high-grade lesions can progress to
anal
cancer over
time
.
Anal
cytology has been recommended as
the primary
screening tool for
anal
dysplasia in
the at-risk population.
Anal
cancer has become one of the most common non-AIDS-defining tumors in HIV-infected individuals.
In the era of highly active antiretroviral therapy, the outcome of combined chemoradiotherapy in HIV-positive individuals with
anal
cancer is similar to that in HIV-negative persons.
Penile and oral HPV-associated
diseases
seem to be more frequent in HIV-positive men than reported for HIV-negative heterosexual men.
SUMMARY:
Diagnostic and
therapeutic guidelines should be implemented for at-risk populations for
anal
dysplasia
/
anal
cancer, such as HIV-positive men who have sex with men.
More
study
is required to get better insights into the natural history of penile and oral HPV-associated benign and malignant lesions.
[MeSH-major]
Anus
Neoplasms / epidemiology.
Anus
Neoplasms / virology. HIV Infections / complications. Papillomaviridae / isolation & purification. Papillomavirus Infections / complications. Papillomavirus Infections / epidemiology
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(PMID = 19276878.001).
[ISSN]
1473-6527
[Journal-full-title]
Current opinion in infectious diseases
[ISO-abbreviation]
Curr. Opin. Infect. Dis.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
40
15.
Truesdale MD, Goldstone SE:
The fear factor: drivers and barriers to follow-up screening for human papillomavirus-related anal cancer in men who have sex with men.
Int J STD AIDS
; 2010 Jul;21(7):482-8
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[Title]
The fear factor: drivers and barriers to follow-up screening for human papillomavirus-related
anal
cancer in men who have sex with men.
Human papillomavirus (HPV)-related
anal
cancer incidence is rising in men who have sex with men (MSM).
Retrospective chart review identified MSM with
anal
dysplasia
.
From June 2007 to March 2008, subjects completed a questionnaire in-person at
the time
of screening or via telephone (LTF).
Questionnaires were completed after
anal
dysplasia
diagnosis
.
RF were more likely to describe their HPV
diagnosis
as 'upsetting' (P = 0.003).
MSM with high-grade
intraepithelial
lesions (HSIL) were more likely to be RF versus those with low-grade
intraepithelial
lesions (P = 0.001.
Positive predictors for screening compliance include an upsetting experience during the HPV
diagnosis
, physical symptoms driving the initial visit and HSIL.
[MeSH-major]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / psychology. Early Detection of Cancer / psychology. Homosexuality, Male. Papillomavirus Infections /
diagnosis
.
Patient
Compliance / statistics & numerical data
Genetic Alliance.
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clinical trials - ClinicalTrials.gov
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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(PMID = 20852198.001).
[ISSN]
1758-1052
[Journal-full-title]
International journal of STD & AIDS
[ISO-abbreviation]
Int J STD AIDS
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
16.
M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA:
Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine.
Biochem Biophys Res Commun
; 2007 Feb 16;353(3):829-34
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[Title]
Detection of pre-neoplastic and neoplastic prostate
disease
by MALDI profiling of urine.
Existing prostate cancer screening paradigms have relatively poor specificity for cancer relative to other prostate
diseases
, commonly benign prostatic hyperplasia (BPH).
A method for
discrimination of
BPH, HGPIN, and PCa urine proteome was developed through testing 407
patient
samples using matrix assisted laser desorption-mass spectrometry
time of
flight (MALDI-TOF).
The high throughput, low-cost assay method developed is amenable for large
patient numbers
required for supporting biomarker identification.
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[
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[
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Urol Oncol. 2004 Jul-Aug;22(4):322-8
[
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[
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[
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]
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[
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]
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Anal Chem. 2000 Feb 15;72(4):757-63
[
10701260.001
]
(PMID = 17194448.001).
[ISSN]
0006-291X
[Journal-full-title]
Biochemical and biophysical research communications
[ISO-abbreviation]
Biochem. Biophys. Res. Commun.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R21 CA098348; United States / NCI NIH HHS / CA / CA098348-02; United States / NCI NIH HHS / CA / P30 CA068485; United States / NIGMS NIH HHS / GM / K12 GM068543-04; United States / NIGMS NIH HHS / GM / K12 GM068543; United States / NCI NIH HHS / CA / CA68485; United States / NIGMS NIH HHS / GM / GM068543-04; United States / NCI NIH HHS / CA / CA98348; United States / NIGMS NIH HHS / GM / 5K12GM068543; United States / NCI NIH HHS / CA / R21 CA098348-02
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Peptides
[Other-IDs]
NLM/ NIHMS16682; NLM/ PMC2562600
17.
Chiao EY, Giordano TP, Palefsky JM, Tyring S, El Serag H:
Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review.
Clin Infect Dis
; 2006 Jul 15;43(2):223-33
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[Title]
Screening HIV-infected individuals for
anal
cancer precursor lesions: a systematic review.
Individuals with human immunodeficiency virus (HIV) infection are at increased risk for human papillomavirus-related
squamous
cell cancer of the
anus
.
Screening HIV-infected patients for
squamous
cell cancer of the
anus and
human papillomavirus-related
anal
dysplasia may
prevent excess morbidity and mortality.
We have conducted a systematic review of the indirect evidence in the literature regarding the utility of
anal
Papanicolau (Pap) smear screening of HIV-infected individuals in the highly active antiretroviral therapy era.
Although there are no published studies evaluating the efficacy of
anal
Pap smear screening for preventing
squamous
cell cancer of the
anus
or
anal intraepithelial neoplasia
, we reviewed data regarding the burden
of disease
,
anal
Pap smear sensitivity and specificity, the prevalence of
anal
dysplasia
,
and 1
cost effectiveness
study
.
The available evidence demonstrates that HIV-infected individuals have an increased risk for
squamous
cell cancer of the
anus and
anal intraepithelial neoplasia
.
This review identifies important areas for further
study
before routine
anal
Pap smear screening can be recommended.
[MeSH-major]
Anus
Neoplasms /
diagnosis
. Carcinoma,
Squamous
Cell /
diagnosis
. HIV Infections / complications. Papanicolaou Test. Papillomavirus Infections /
diagnosis
. Precancerous Conditions /
diagnosis
.
Vaginal
Smears
[MeSH-minor]
Antiretroviral Therapy, Highly Active. Carcinoma in Situ /
diagnosis
. Carcinoma in Situ / etiology. Female. Humans. Male. Mass Screening. Papillomaviridae
Genetic Alliance.
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(PMID = 16779751.001).
[ISSN]
1537-6591
[Journal-full-title]
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
[ISO-abbreviation]
Clin. Infect. Dis.
[Language]
eng
[Grant]
United States / NIMH NIH HHS / MH / K23MH67505
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Review
[Publication-country]
United States
[Number-of-references]
100
18.
Papachristou F, Printza N, Farmaki E, Leontsini M, Kavaki D, Kollios K:
Antibiotics-induced acute interstitial nephritis in 6 children.
Urol Int
; 2006;76(4):348-52
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INTRODUCTION: Antibiotics-induced acute interstitial nephritis (
AIN
) is a rare
disorder in
children, and the
diagnosis
is often delayed.
PATIENTS AND METHODS: We reviewed the medical records of 6 children, age range from 10 months to 14 years, with biopsy-confirmed antibiotics-induced
AIN
.
RESULTS: Symptoms
of AIN
started 2-4 weeks after antimicrobial therapy with beta-lactam antibiotics in 5 children and with gentamicin
in 1
child.
The glomerular filtration rate was dramatically reduced
in 2
cases and mildly reduced in 4 patients.
Two of our patients had supportive treatment, 2 received corticosteroid therapy,
and 2
children remained under peritoneal
dialysis
for 12 and 22 days, respectively.
Five patients had a full recovery of their renal function,
and 1
child, 2 years later, still presented impairment of the renal function.
CONCLUSION:
AIN
should be considered
in case
of acute renal failure in children, mostly when other common causes have been excluded, and there is a history of drug exposure.
[MeSH-minor]
Acute
Disease
. Adolescent. Child. Female. Humans. Infant. Male
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[Copyright]
2006 S. Karger AG, Basel.
(PMID = 16679839.001).
[ISSN]
0042-1138
[Journal-full-title]
Urologia internationalis
[ISO-abbreviation]
Urol. Int.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Anti-Bacterial Agents
19.
Palefsky JM:
HPV infection in men.
Dis Markers
; 2007;23(4):261-72
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While much is known about the natural history of cervical human papillomavirus (HPV) infection and its consequences, including cervical
intraepithelial neoplasia
and cervical cancer, relatively little is known about the natural history of anogenital HPV infection
and diseases
in men.
Anal
HPV infection
and disease
also remain poorly understood.
Although HPV is transmitted sexually and infects the genitals of both sexes, the cervix remains biologically more vulnerable to malignant transformation than does the penis or
anus in
men.
However, it is also important due to the burden
of disease
in men, who may develop both penile and
anal
cancer, particularly among HIV-positive men who have sex with men.
Improved sampling techniques of the male genitalia and cohort studies in progress should provide important information on the natural history of anogenital HPV infection
and disease
in men, including risk factors for HPV acquisition and transmission.
[MeSH-major]
Genital
Diseases
, Male / etiology. Papillomavirus Infections / etiology
[MeSH-minor]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / etiology.
Anus
Neoplasms / virology. Carcinoma in Situ / etiology. Carcinoma in Situ / virology. Condylomata Acuminata / etiology. Condylomata Acuminata / virology. Female. Humans. Male. Papillomaviridae / genetics. Papillomaviridae / isolation & purification. Papillomaviridae / pathogenicity. Penile Neoplasms /
diagnosis
. Penile Neoplasms / etiology. Penile Neoplasms / virology. Sexual Partners
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(PMID = 17627061.001).
[ISSN]
0278-0240
[Journal-full-title]
Disease markers
[ISO-abbreviation]
Dis. Markers
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Netherlands
[Number-of-references]
78
[Other-IDs]
NLM/ PMC3851123
20.
Scholefield JH, Castle MT, Watson NF:
Malignant transformation of high-grade anal intraepithelial neoplasia.
Br J Surg
; 2005 Sep;92(9):1133-6
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[Title]
Malignant transformation of high-grade
anal intraepithelial neoplasia
.
BACKGROUND: The natural history of
anal intraepithelial neoplasia
(
AIN
) is uncertain.
METHODS: All patients were
diagnosed
with high-grade
AIN
(
AIN
III) between 1994 and 2003.
Diagnosis
was by full-thickness biopsy and histopathological examination.
Excision of localized high-grade
AIN
was carried out in 28 patients with minimal morbidity.
Six patients were systemically immunosuppressed at
diagnosis
, all of whom had multifocal
perianal
lesions.
Three immunosuppressed patients developed invasive
anal
squamous
carcinoma during follow-up.
By contrast, no invasive carcinomas were identified among immunocompetent patients with either localized or multifocal
perianal disease
.
CONCLUSION:
AIN
III appears to have a relatively low potential for malignant transformation in the immunocompetent
patient
.
However, immunosuppressed patients are more likely to have extensive
AIN
III and a greater risk of malignant change.
[MeSH-major]
Anus
Neoplasms / pathology. Carcinoma in Situ / pathology. Cell Transformation, Neoplastic / pathology
[MeSH-minor]
Adult. Carcinoma,
Squamous
Cell / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local. Prospective Studies
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[Copyright]
Copyright 2005 British Journal of Surgery Society Ltd.
(PMID = 16044425.001).
[ISSN]
0007-1323
[Journal-full-title]
The British journal of surgery
[ISO-abbreviation]
Br J Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
21.
Sella R, Flomenblit L, Goldstein I, Kaplinsky C:
Detection of anti-neutrophil antibodies in autoimmune neutropenia of infancy: a multicenter study.
Isr Med Assoc J
; 2010 Feb;12(2):91-6
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[Title]
Detection of anti-neutrophil antibodies in autoimmune neutropenia of infancy: a multicenter
study
.
Primary AIN
is characterized by neutrophil count < 500 ml and a benign self-limiting course.
Detecting specific antibodies against the polymorphic human neutrophil
antigen
usually confirms the
diagnosis
.
METHODS: We evaluated 120 children with a clinical suspicion
of AIN
, whose sera were analyzed by flow cytometry for the presence of autoantibodies using the indirect granulocyte immunofluorescence test.
RESULTS: Our method showed specificity of 85%, sensitivity of 62.5%, and a positive predictive
value of
91.8%, values quite similar to those obtained by more traditional methods.
[MeSH-major]
Antibodies, Antineutrophil Cytoplasmic /
blood
. Autoimmune
Diseases
/ immunology. Neutropenia / immunology
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(PMID = 20550032.001).
[ISSN]
1565-1088
[Journal-full-title]
The Israel Medical Association journal : IMAJ
[ISO-abbreviation]
Isr. Med. Assoc. J.
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
Israel
[Chemical-registry-number]
0 / Antibodies, Antineutrophil Cytoplasmic
22.
Dedes KJ, Beneder C, Samartzis N, Muller MD, Fink D, Fehr MK:
Outcome of treated anogenital intraepithelial neoplasia among human immunodeficiency virus-infected women.
J Reprod Med
; 2008 Dec;53(12):947-51
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[Title]
Outcome of treated anogenital
intraepithelial neoplasia
among human immunodeficiency virus-infected women.
OBJECTIVE: To determine characteristics and clinical course of high-grade anogenital
intraepithelial neoplasia
(
AIN
) in human immunodeficiency virus (HIV)-infected women.
STUDY
DESIGN: HIV-positive women with biopsy-proven high-grade (II and III) vulvar (VIN),
vaginal
(VAIN) or
perianal
intraepithelial neoplasia
(PAIN) were identified in the electronic databases
of 2
colposcopy clinics.
Of the patients, 77.4% had VIN, 12.9% VAIN and 9.7% PAIN at
first
diagnosis
.
Age at
diagnosis
of IN was 36.2 years (SD +/- 5.2; range, 23.5-47.0).
Ninety percent of patients received antiretroviral therapy at
first
diagnosis
of IN; 65% (13 of 20) of patients with a follow-up of > 2 years required a second treatment,
and 2
developed invasive vulvar cancer (10%).
CONCLUSION:
AIN
among HIV-positive women shows a high relapse rate despite treatment modality used and a substantial invasive potential.
[MeSH-major]
Anus
Neoplasms / therapy. Carcinoma in Situ / therapy. HIV Infections / complications.
Vaginal
Neoplasms / therapy. Vulvar Neoplasms / therapy
[MeSH-minor]
Adult. Cohort Studies.
Disease
-Free Survival. Female. Humans. Middle Aged. Retrospective Studies. Young Adult
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(PMID = 19160654.001).
[ISSN]
0024-7758
[Journal-full-title]
The Journal of reproductive medicine
[ISO-abbreviation]
J Reprod Med
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
23.
Eid HO, Hefny AF, Joshi S, Abu-Zidan FM:
Non-traumatic perforation of the small bowel.
Afr Health Sci
; 2008 Mar;8(1):36-9
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Diseases
that cause small bowel perforation vary in different areas of the world.
OBJECTIVE: To highlight difficulties in the
diagnosis
and management of non-traumatic perforation of small bowel.
MATERIAL AND METHODS: The medical records of four patients who have presented with non-traumatic perforation of the small bowel and were treated at Al-
Ain
Hospital during the last 5 years were studied retrospectively.
Erect chest X-ray has shown free air under diaphragm
in 3
patients.
Leukocytosis was present in only one
patient
.
HIV was confirmed in one
patient
.
Patients were
diagnosed
to have typhoid, HIV, hook worms and tuberculosis.
Only the HIV
patient
died while the others were discharged home in a good condition.
CONCLUSION: Clinical findings of small bowel perforation are usually non specific and
diagnosis
is usually reached after surgery.
[MeSH-major]
Cytomegalovirus Infections / complications. Hookworm Infections / complications. Ileal
Diseases
/ etiology. Intestinal Perforation / etiology. Typhoid Fever / complications
[MeSH-minor]
Adult. Aged. Anti-Bacterial Agents / administration & dosage. Anti-Bacterial Agents / therapeutic use. Antinematodal Agents / administration & dosage. Antinematodal Agents / therapeutic use. Crohn
Disease
/ complications. Crohn
Disease
/
diagnosis
.
Diagnosis
,
Differential
. Fatal Outcome. Humans. Laparotomy. Male. Mebendazole / administration & dosage. Mebendazole / therapeutic use. Middle Aged. Retrospective Studies.
Time
Factors. Treatment Outcome. Tuberculosis / complications. Tuberculosis /
diagnosis
. Tuberculosis, Gastrointestinal / complications. Tuberculosis, Gastrointestinal /
diagnosis
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.
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[Cites]
Am Surg. 2000 Feb;66(2):219-22
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10695758.001
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9112919.001
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(PMID = 19357730.001).
[ISSN]
1729-0503
[Journal-full-title]
African health sciences
[ISO-abbreviation]
Afr Health Sci
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Uganda
[Chemical-registry-number]
0 / Anti-Bacterial Agents; 0 / Antinematodal Agents; 81G6I5V05I / Mebendazole
[Other-IDs]
NLM/ PMC2408541
24.
Al-Hammadi S, Al-Maskari F, Bernsen R:
Prevalence of food allergy among children in Al-Ain city, United Arab Emirates.
Int Arch Allergy Immunol
; 2010;151(4):336-42
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[Title]
Prevalence of food allergy among children in Al-
Ain
city, United Arab Emirates.
However, the prevalence of FA in the United Arab Emirates (UAE) has
not
yet been determined.
This cross-sectional
study
was carried out to assess the prevalence of FA among school children aged 6-9 years in Al-
Ain
city, UAE.
METHODS: We used multistage random sampling in order to get a sample of 397 school children whose parents completed a self-administered questionnaire designed to assess the presence or absence of physician
diagnosis
of FA and other allergic
diseases
.
RESULTS:
The study
showed that the prevalence of physician-
diagnosed
FA in children was 8% (95% CI 5.4-10.8%).
FA was independently related to a family history of FA, to a small sibship size and to a personal history of other atopic
diseases
.
CONCLUSIONS: The prevalence of FA in Al-
Ain
city was 8%.
A history of FA
in first
-degree family members and a small sibship size were associated with a higher risk of FA in children.
FA was related to a personal history of other atopic
diseases
.
[MeSH-minor]
Child. Cross-Sectional Studies. Female. Fish
Products
/ adverse effects. Humans. Male. Prevalence. Risk Factors. Surveys and Questionnaires. United Arab Emirates
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[Copyright]
2009 S. Karger AG, Basel.
(PMID = 19851075.001).
[ISSN]
1423-0097
[Journal-full-title]
International archives of allergy and immunology
[ISO-abbreviation]
Int. Arch. Allergy Immunol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Allergens
25.
Tadic M, Grgurevic I, Scukanec-Spoljar M, Bozic B, Marusic S, Horvatic I, Galesic K:
Acute interstitial nephritis due to mesalazine.
Nephrology (Carlton)
; 2005 Apr;10(2):103-5
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A
case of
mesalazine-induced acute interstitial nephritis (
AIN
) in a 41-year-old
patient
with ulcerative colitis (UC) is reported here.
Clinical symptoms such as fever and arthralgia, and laboratory findings such as eosinophilia and renal failure suggested
AIN
, which was confirmed by biopsy.
With withdrawal of mesalazine and intravenous methylprednisolone
the patient
's renal function was recovered.
Delayed
diagnosis
may lead to permanent renal function impairment.
[MeSH-minor]
Acute
Disease
. Adult. Humans. Male
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(PMID = 15877665.001).
[ISSN]
1320-5358
[Journal-full-title]
Nephrology (Carlton, Vic.)
[ISO-abbreviation]
Nephrology (Carlton)
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 4Q81I59GXC / Mesalamine
26.
Walts AE, Lechago J, Bose S:
P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia.
Am J Surg Pathol
; 2006 Jul;30(7):795-801
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[Title]
P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated
anal intraepithelial neoplasia
.
P16 is a
tumor
suppressor gene
product
, shown to be overexpressed in most cervical carcinomas and dysplasias associated with high-risk human papilloma virus (HPV) infection.
HPV is also associated with
anal
squamous
dysplasias and carcinomas.
Significant interobserver and intraobserver variation exists in the
interpretation of
biopsies for
anal intraepithelial neoplasia
(
AIN
).
This
study
was undertaken to assess the potential role of p16 and Ki67 immunohistochemical expression in refining the
diagnosis
and grading
of AIN
.One-hundred and four
anal
biopsies from 74 patients were retrieved from the surgical pathology files of the department.
After discrepancies were resolved and concurrence was achieved by at least
2 of
3 reviewing pathologists,
the diagnoses
were as follows: 37 negative, 12 condylomas without overt
dysplasia
, 14
AIN
I, 25
AIN
II, and 16
AIN
III. p16 and Ki67 expression was evaluated by ABC immunoperoxidase staining whereas the presence of the high-risk subtypes of HPV virus was determined by in situ hybridization on a subset of the biopsies.
Results were reviewed by 2 pathologists and positive and negative staining was correlated with H&E
diagnoses
.
Nuclear and
/or
nuclear and
cytoplasmic staining was considered as positive for p16 when present in >10%
of squamous
cells.
A band-like pattern of p16 immunoreactivity was seen in 21.4%
AIN
I, 80%
AIN
II, and 87.5%
AIN
III cases.
None of the condylomas and only
1 of
the negative cases showed a band of p16 positive staining.
Spotty p16 immunoreactivity was observed in 8.1% negative, 8.3% condyloma, 14.3%
AIN
I, 12.0%
AIN
II, and 12.5%
AIN
III cases.
More than 50% of nuclei stained positive for Ki67 in 28.6%
AIN
I, 48.0%
AIN
II, and 75.0%
AIN
III cases but in none of the negative or condyloma cases.
On the basis of these results, a band-like pattern of p16 staining and Ki67 positivity in >50% of the
squamous
cell nuclei were strongly associated with high-grade
AIN
.
Most
AIN
I lesions stained similar to the nondysplastic cases.
A small subset of biopsies studied did
not
conform to the pattern described above: 4 of 14 (28.6%)
AIN
I lesions showed a band-like pattern of p16 staining and/or >50% Ki67 positive nuclei.
4 of 25 (16.0%)
AIN
II lesions comprising 9.8% of the 41 high-grade AINs (
AIN
II and III) showed spotty p16 positivity and <50% Ki67 positive nuclei.
We conclude that when used together and evaluated in conjunction with H&E stained sections, p16 and Ki67 immunoexpression is a useful adjunct in the
diagnosis
and grading
of AIN
.
[MeSH-major]
Anus
Neoplasms / pathology. Carcinoma in Situ / pathology. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ki-67
Antigen
/ metabolism. Papillomavirus Infections / pathology. Precancerous Conditions / pathology
[MeSH-minor]
Adult. Aged. Biomarkers,
Tumor
/ metabolism. Biopsy. Cell
Nucleus
/ metabolism. Cell
Nucleus
/ pathology. DNA, Viral / analysis. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization. Male. Middle Aged. Papillomaviridae / genetics. Papillomaviridae / isolation & purification
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(PMID = 16819320.001).
[ISSN]
0147-5185
[Journal-full-title]
The American journal of surgical pathology
[ISO-abbreviation]
Am. J. Surg. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / Ki-67 Antigen
27.
Bean SM, Meara RS, Vollmer RT, Conner MG, Crowe DR, Novak L, Eltoum IA, Robboy SJ, Chhieng DC:
p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.
J Low Genit Tract Dis
; 2009 Jul;13(3):145-53
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[Title]
p16 Improves interobserver agreement in
diagnosis
of
anal intraepithelial neoplasia
.
OBJECTIVES: Evaluation of
anal intraepithelial neoplasia
(
AIN
) is subjective.
Previous studies have shown p16 and Ki-67 expressions to correlate with
AIN
grade.
The objectives were (1) to determine the extent of interobserver agreement in evaluating
AIN
on routine hematoxylin and eosin (H&E) sections and (2) to test whether p16 and/or Ki-67 staining improve interobserver
diagnostic
agreement.
MATERIALS AND METHODS: Seventy-seven
anal
specimens were retrieved.
Blind to the original
diagnoses
, 4 pathologists assessed H&E alone, p16 alone, Ki-67 alone, and all 3 simultaneously.
Diagnoses
were normal/reactive,
AIN
I/HPV,
AIN
II,
and AIN
III.
Fair agreement was observed using H&E
diagnosis
alone (kappa = 0.38, S = 0.56).
The p16
diagnostic
evaluation demonstrated the highest agreement (kappa = 0.57, S = 0.73).
When the pathologists'
diagnoses
for all
diagnostic
evaluations were compared with consensus
diagnoses
, the lowest average magnitude of disagreement was seen with Ki-67 alone, followed by p16 alone, H&E/p16/Ki-67 combined, and H&E alone.
CONCLUSIONS: Interobserver agreement for
diagnosis
of AIN
was fair when based solely on H&E preparation. p16 alone improved interobserver agreement and demonstrated superior agreement when compared with H&E, Ki-67, and H&E/p16/Ki-67 combined.
[MeSH-major]
Anus
Neoplasms /
diagnosis
. Carcinoma in Situ /
diagnosis
. DNA, Neoplasm / analysis. Gene Expression Regulation, Neoplastic. Genes, p16 / physiology
[MeSH-minor]
Adult. Aged. Aged, 80 and over.
Antigens
, Neoplasm / analysis. Biopsy. Clinical Competence.
Diagnosis
,
Differential
. Female. Humans. Male. Middle Aged. Observer Variation. Retrospective Studies
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(PMID = 19550211.001).
[ISSN]
1526-0976
[Journal-full-title]
Journal of lower genital tract disease
[ISO-abbreviation]
J Low Genit Tract Dis
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Neoplasm; 0 / DNA, Neoplasm
28.
Kreepala C, Changsirikulchai S, Chalermsanyakorn P:
Pulmonary hemorrhage with acute renal injury in a patient with IgA nephropathy.
J Med Assoc Thai
; 2009 Jun;92 Suppl 3:S80-4
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[Title]
Pulmonary hemorrhage with acute renal injury in a
patient
with IgA nephropathy.
IgA nephropathy (IgAN) is a form of glomerular
diseases
which is usually aggravated by infection in respiratory or gastrointestinal systems.
Acute interstitial nephritis (
AIN
) has been previously described as an unusual cause of acute renal injury in IgAN.
We reported a
patient
who presented with fever hemoptysis from diffuse pulmonary hemorrhage, and acute renal injury.
Renal biopsy revealed IgAN concomitant with
AIN
which was the cause of renal
dysfunction
.
Renal biopsy is a mandatory investigation to make the correct
diagnosis
.
[MeSH-major]
Glomerulonephritis, IGA /
diagnosis
. Hemoptysis / drug therapy. Lung
Diseases
/
diagnosis
. Nephritis, Interstitial /
diagnosis
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(PMID = 19702073.001).
[ISSN]
0125-2208
[Journal-full-title]
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
[ISO-abbreviation]
J Med Assoc Thai
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Thailand
[Chemical-registry-number]
0 / Anti-Bacterial Agents; 75J73V1629 / Ceftriaxone; N12000U13O / Doxycycline
29.
Walts AE, Lechago J, Hu B, Shwayder M, Sandweiss L, Bose S:
P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN).
Clin Med Pathol
; 2008;1:7-13
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[Title]
P16 and Ki67 Immunostains Decrease
Intra
- and Interobserver Variability in the
Diagnosis
and Grading of
Anal Intraepithelial Neoplasia
(
AIN
).
BACKGROUND: Significant variation is reported in the
diagnosis
of HPV-associated
AIN
.
We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade
AIN
.
This
study
was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce
inter
- and intraobserver variability in
diagnosis
and grading
of AIN
.
DESIGN: H&E stained slides of 60
anal
biopsies were reviewed by three pathologists and consensus
diagnoses
were achieved: 25 negative, 12 low (condyloma and/or
AIN
I) and 23 high (9
AIN
II and 14
AIN
III) grade lesions.
The H&E stained slides were
diagnosed
independently by three additional ("participant") pathologists.
RESULTS: Addition of p16 and Ki67 immunostains reduced
intra
- and interobserver variability, improved concurrence with consensus
diagnoses and
reduced two-step differences in
diagnosis
.
Negative and high grade
AIN diagnoses
showed the most improvement in concurrence levels.
CONCLUSION: Addition of p16 and Ki67 immunostains is helpful in the
diagnosis
and grading
of AIN
.
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[Cites]
Semin Oncol. 2000 Aug;27(4):471-9
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]
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J Acquir Immune Defic Syndr. 2001 Dec 15;28(5):422-8
[
11744829.001
]
(PMID = 21876646.001).
[ISSN]
1178-1181
[Journal-full-title]
Clinical medicine. Pathology
[ISO-abbreviation]
Clin Med Pathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
New Zealand
[Other-IDs]
NLM/ PMC3159996
[Keywords]
NOTNLM ; Ki67 / P16 / anal intraepithelial neoplasia (AIN) / condyloma / human papilloma virus (HPV) / interobserver variability / intraobserver variability
30.
Ochi K, Horiuchi Y, Tazaki K, Nishi K, Kawashima H, Yabe H:
Spontaneous anterior interosseous nerve palsy with Churg-Strauss syndrome.
Mod Rheumatol
; 2010 Oct;20(5):514-7
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A 74-year-old woman
diagnosed
with Churg-Strauss syndrome (CSS) complained of difficulty in flexing her
left
thumb
and index
finger.
Electromyography demonstrated isolated anterior interosseous nerve (
AIN
) palsy, with no other peripheral neuropathy.
We
diagnosed
this
case
as spontaneous
AIN
palsy complicated with CSS,
the first case of
this kind.
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PREDNISONE
.
Hazardous Substances Data Bank.
METHYLPREDNISOLONE
.
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(PMID = 20458608.001).
[ISSN]
1439-7609
[Journal-full-title]
Modern rheumatology
[ISO-abbreviation]
Mod Rheumatol
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Glucocorticoids; VB0R961HZT / Prednisone; X4W7ZR7023 / Methylprednisolone
31.
Pantanowitz L, Leiman G, Dezube BJ:
Editorial comment: screening for anal dysplasia--are we on the same page?
AIDS Read
; 2009 May;19(5):182-3
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[Title]
Editorial comment: screening for
anal
dysplasia
--are we on the same page?
[MeSH-major]
Anus
Neoplasms /
diagnosis
. Carcinoma in Situ /
diagnosis
. HIV Infections /
diagnosis
. Mass Screening. Precancerous Conditions /
diagnosis
[MeSH-minor]
Anal
Canal
/ pathology. Carcinoma,
Squamous
Cell /
diagnosis
. Carcinoma,
Squamous
Cell / pathology. Carcinoma,
Squamous
Cell / prevention & control. Humans. Male. Washington / epidemiology
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[CommentOn]
AIDS Read. 2009 May;19(5):178-86
[
19554736.001
]
(PMID = 19554737.001).
[ISSN]
1053-0894
[Journal-full-title]
The AIDS reader
[ISO-abbreviation]
AIDS Read
[Language]
eng
[Publication-type]
Comment; Editorial
[Publication-country]
United States
32.
Sassone J, Schaefer W, Schwartz T, Valenti WM:
Trends in HIV care, Part 1: new antiretrovirals, anal dysplasia, and reimbursement for diagnostic testing--a roundtable discussion.
AIDS Read
; 2008 Dec;18(12):615-21
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[Title]
Trends in HIV care, Part 1: new antiretrovirals,
anal
dysplasia
, and reimbursement for
diagnostic
testing--a roundtable discussion.
[MeSH-major]
AIDS-Related Opportunistic Infections. Anti-Retroviral Agents / therapeutic use.
Anus Diseases
.
Diagnostic
Techniques and Procedures / economics. HIV Infections /
diagnosis
. Insurance, Health, Reimbursement. Papillomavirus Infections
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.
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(PMID = 19123280.001).
[ISSN]
1053-0894
[Journal-full-title]
The AIDS reader
[ISO-abbreviation]
AIDS Read
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Anti-Retroviral Agents
33.
Walts AE, Bose S:
BD ProEx C immunostaining in extramammary Paget's disease and perineal melanoma.
Mod Pathol
; 2009 Feb;22(2):246-51
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[Title]
BD ProEx C immunostaining in extramammary Paget's
disease and
perineal melanoma.
The differential
diagnosis
of perineal biopsies can include
squamous
intraepithelial
lesions, extramammary Paget's
disease
, and melanoma.
Immunostaining for ProEx C has been validated in cervical cytology and positive staining has also been shown to be strongly associated with human papilloma virus (HPV)-induced cervical and
anal intraepithelial neoplasia
in biopsies.
We observed positive staining for ProEx C in Paget cells in all of 26 cases of Paget's
disease
irrespective of tissue site (extramammary, mammary) and in melanoma cells in all of 12 cases
of primary
perineal melanoma with immunostaining in >50% of malignant cells in 73% of Paget
disease
cases and 43% of perineal melanoma cases.
Positive staining was heterogeneous and exclusively
nuclear in
all cases.
[MeSH-major]
Antigens
, Neoplasm / analysis.
Anus
Neoplasms / enzymology. Cell Cycle Proteins / analysis. DNA Topoisomerases, Type II / analysis. DNA-Binding Proteins / analysis. Melanoma / enzymology.
Nuclear
Proteins / analysis. Paget
Disease
, Extramammary / enzymology. Perineum / pathology. Reagent Kits,
Diagnostic
.
Vaginal
Neoplasms / enzymology. Vulvar Neoplasms / enzymology
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Alphapapillomavirus / genetics. Alphapapillomavirus / isolation & purification. Biopsy. DNA, Viral / isolation & purification.
Diagnosis
,
Differential
. Female. Humans. Immunoassay. In Situ Hybridization. Male. Middle Aged. Minichromosome Maintenance Complex Component 2. Mucous Membrane / enzymology. Mucous Membrane / pathology. Mucous Membrane / virology. Predictive
Value of
Tests
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(PMID = 18931649.001).
[ISSN]
1530-0285
[Journal-full-title]
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
[ISO-abbreviation]
Mod. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens, Neoplasm; 0 / Cell Cycle Proteins; 0 / DNA, Viral; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Reagent Kits, Diagnostic; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
34.
Kreuter A, Brockmeyer NH, Wieland U:
[Anal intraepithelial neoplasia and anal carcinoma: an increasing problem in HIV patients].
Hautarzt
; 2010 Jan;61(1):21-6
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[Title]
[
Anal intraepithelial neoplasia
and
anal
carcinoma: an increasing problem in HIV patients].
[Transliterated title]
Anale intraepitheliale Neoplasie
und Analkarzinom : Ein zunehmendes Problem bei Menschen mit HIV-Infektion.
Anal
dysplasia
is common in HIV patients, especially in HIV-positive men having sex with men (MSM).
High-grade
anal
dysplasia
can progress to invasive
anal
cancer.
As in cervical carcinoma, there is a cause and effect relationship between
anal
cancer and human papillomavirus (HPV) infection, especially with high-risk types such as HPV16.
Several experts have recommended screening programs for
anal
cancer, including
anal
cytology along the lines of the Pap smear in women.
Such screenings should only be performed if pathological findings result in further
diagnostic
steps and, if necessary, appropriate treatment.
Clinical inspection, lesion biopsy, and treatment of
anal
dysplasia
are performed under high-resolution anoscopy.
Anal
cancer is divided into cancer of the
anal
margin and
cancer of the
anal
canal
.
This
classification
is important because of the difference in treatment regimens.
Early cancer of the
anal
margin
is excised akin to
squamous
cell cancer of the exposed skin, whereas cancer of the
anal
canal
is treated by radiochemotherapy.
Physicians working in the field of HIV/AIDS should regularly screen their patients for the presence of
anal
dysplasia and
anal
cancer.
Basic
diagnostic
workup includes clinical inspection of the
perianal
area, digital rectal examination, and
anal
cytology.
[MeSH-major]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / prevention & control. Carcinoma in Situ / virology. HIV Infections / complications. Precancerous Conditions /
diagnosis
. Precancerous Conditions / prevention & control
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[Cites]
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Cancer. 2004 Jul 15;101(2):270-80
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ANZ J Surg. 2006 Aug;76(8):715-7
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Cancer. 2004 Jul 15;101(2):281-8
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]
[Cites]
Curr Opin Oncol. 2009 Sep;21(5):433-8
[
19587592.001
]
(PMID = 19967333.001).
[ISSN]
1432-1173
[Journal-full-title]
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
[ISO-abbreviation]
Hautarzt
[Language]
ger
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Germany
35.
Hullmann M, Reichert TE, Dahse R, von Eggeling F, Pistner H, Kosmehl H, Driemel O:
[Oral cytology: historical development, current status, and perspectives].
Mund Kiefer Gesichtschir
; 2007 Jan;11(1):1-9
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By brushing it is possible to reach deeper layers of the oral mucosa where
squamous
intraepithelial neoplasia
(SIN) begins.
The biological potential of the oral
epithelial
cells obtained can be evaluated by the following additional methods: computer-assisted image analysis (OralCDx), DNA cytometry, immunohistochemistry, monolayer cytology,
and molecular
biological analysis.
Nevertheless, there are reports that oral
epithelial
carcinomas were
not
identified.
No comparative
study
exists allowing conclusions to be drawn about
the value
of the single methods.
Oral brush biopsy as a non invasive
diagnostic
method can be useful for the early detection of oral mucosal lesions.
Positive findings or progression of the lesion despite negative findings are indications to refer
the patient
to a specialized clinic where a surgical biopsy should be performed, followed by histopathological analysis.
Histopathology remains the gold standard for the definitive
diagnosis
of oral malignant lesions.
[MeSH-major]
Carcinoma in Situ / pathology. Carcinoma,
Squamous
Cell / pathology. Cytological Techniques / methods. Mouth Neoplasms / pathology
[MeSH-minor]
Biomarkers,
Tumor
/ analysis. Biopsy / methods. Cell Adhesion Molecules / analysis. DNA, Neoplasm / analysis. Humans. Image Processing, Computer-Assisted. Immunohistochemistry. Mouth Mucosa / pathology. Sensitivity and Specificity
MedlinePlus Health Information.
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.
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Mund Kiefer Gesichtschir. 2004 Jul;8(4):229-36
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(PMID = 17177045.001).
[ISSN]
1432-9417
[Journal-full-title]
Mund-, Kiefer- und Gesichtschirurgie : MKG
[ISO-abbreviation]
Mund Kiefer Gesichtschir
[Language]
ger
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Germany
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / DNA, Neoplasm; 0 / kalinin
[Number-of-references]
107
36.
Al-Muhairi SS, Zoubeidi TA, Ellis ME, Safa WF, Joseph J:
Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates.
Saudi Med J
; 2006 Jul;27(7):1044-8
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[Title]
Risk factors predicting outcome in patients with pneumonia in Al-
Ain
, United Arab Emirates.
OBJECTIVE: To determine the predictive
value of
commonly used clinical and laboratory factors for mortality in patients with pneumonia in the Arab world.
METHODS: We retrospectively analyze the data collected from all inpatients over the age of 16 years with a
diagnosis
of pneumonia in Tawam Hospital, Al-
Ain
, United Arab Emirates between the years 1997 and 2002.
The most common comorbid risk factors were diabetes mellitus in 23.7% and chronic obstructive pulmonary
disease in
19.5%.
Simple logistic regression analysis showed increasing age, presence of comorbidity, low systolic
blood
pressure, confused mental status, low serum albumin, high serum creatinine, raised
blood
urea nitrogen and raised partial pressure of carbon dioxide at
the time
of admission were associated with higher mortality.
On the Stepwise-multilogistic regression analysis, the most significant factors influencing mortality were: older age, altered mental status, low systolic
blood
pressure, low serum albumin and raised serum creatinine.
Older age, altered mental status, low systolic
blood
pressure, low serum albumin concentration and raised serum creatinine at admission were predictive of poor outcome in this cohort of patients.
[MeSH-major]
Pneumonia /
diagnosis
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Diabetes Mellitus, Type 2 / complications. Female. Humans. Male. Middle Aged. Prognosis. Pulmonary
Disease
, Chronic Obstructive / complications. ROC Curve. Retrospective Studies. Risk Factors. United Arab Emirates / epidemiology
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(PMID = 16830028.001).
[ISSN]
0379-5284
[Journal-full-title]
Saudi medical journal
[ISO-abbreviation]
Saudi Med J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Saudi Arabia
37.
El-Debeiky MS, Safan HA, Shafei IA, Kader HA, Hay SA:
Long-term functional evaluation of fecal continence after laparoscopic-assisted pull-through for high anorectal malformations.
J Laparoendosc Adv Surg Tech A
; 2009 Apr;19 Suppl 1:S51-4
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BACKGROUND: The use of laparoscopy while performing an abdominal dissection for the mobilization of rectovesical fistula should have an impact on anorectal function, as compared to the original
posterior
sagittal anorectoplasty, where muscle complex was
not
cut and the rectum was pulled in a way similar to the old techniques for the abdominoperineal pull-through.
MATERIALS AND METHODS: A prospective
case study
included 15 patients treated with a laparoscopic-assisted pull-through for high anorectal malformation.
After the approval of the Ethical Committee for Medical Research in the Department of Surgery at
Ain
Sams University (Cairo, Egypt) and obtaining an informed consent from the parents, they were subjected to a full clinical history and a checklist about motions and soiling to be filled in over 1 month, a barium enema to check for any dilatation, anorectal manometry to evaluate resting pressure, maximum squeezing pressure, and sphincter relaxation, and MRI (magnetic resonance imaging) to evaluate the central situation of the rectum within the sphincter and the degree of development of the sphincter.
RESULTS: Six of 9 patients are clean without any attacks of fecal soiling or incontinence, and they evacuate spontaneously but need the application of a rectal suppository for evacuation from
time
to
time
.
Manometry showed a high resting pressure that decreased on straining in the 7 clean patients and low
in 2
.
The resting pressure did
not
increase on squeezing and all showed weak rectoanal inhibitory reflex (RAIR).
One
patient
developed dysurea and constipation 1 year after surgery, as
diagnosed
by VCUG (voiding cystourethrogram) to have a diverticulum at the site of excised fistula causing rectal and urethral obstruction treated by a transabdominal excision with a good functional result.
CONCLUSION: The state of continence with the laparoscopic technique in high anorectal malformations in this
study
showed acceptable results but needs bigger series with longer follow-up for a proper evaluation of this technique.
[MeSH-major]
Anal
Canal
/ abnormalities. Laparoscopy. Rectum / abnormalities
Genetic Alliance.
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(PMID = 19281419.001).
[ISSN]
1092-6429
[Journal-full-title]
Journal of laparoendoscopic & advanced surgical techniques. Part A
[ISO-abbreviation]
J Laparoendosc Adv Surg Tech A
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
38.
Parés D, Mullerat J, Pera M:
[Anal intraepithelial neoplasia].
Med Clin (Barc)
; 2006 Nov 18;127(19):749-55
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[Title]
[
Anal intraepithelial neoplasia
].
[Transliterated title]
Neoplasia
intraepitelial
anal
.
Human papillomavirus (HPV) is responsible for
anal
condylomata,
anal intraepithelial neoplasia
(
AIN
) and
anal
squamous
cell carcinoma.
AIN
is a premalignant condition that can progress to invasive carcinoma through different grades of severity of the
disease
called
AIN
I,
AIN
II
and AIN
III.
This paper looks at the current definition,
diagnostic
methods and management
of AIN
.
The incidence
of AIN
has increased significantly in the last decades.
The groups at risk are mainly patients with infection with human immunodeficiency virus, immunossuppressed patients and patients affected by HPV related
diseases
(e.g., cervical cancer or
anal
condyloma).
Accurate
diagnosis
of AIN
lesions consists of accurate grading
and disease
extension.
Low grade
AIN
(
AIN
I) or in extensive lesions, follow-up is advised to determine the possible evolution to
anal
squamous
cell carcinoma.
In cases of more severe and localized lesions (
AIN
II
and AIN
III), surgical resection should be considered if the predictive postoperative morbidity is low.
Screening programs for
AIN
are
not
currently in place and there might be much effort to
study the
management of HPV in these patients.
[MeSH-major]
Anus
Neoplasms / pathology. Carcinoma in Situ / pathology
[MeSH-minor]
Anal
Canal
/ pathology.
Anal
Canal
/ surgery. Humans
MedlinePlus Health Information.
consumer health - Anal Cancer
.
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(PMID = 17198654.001).
[ISSN]
0025-7753
[Journal-full-title]
Medicina clínica
[ISO-abbreviation]
Med Clin (Barc)
[Language]
spa
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Spain
[Number-of-references]
58
39.
Mirghani HM, Khair H:
Comparison between visual and computerized cardiotocography in low risk pregnancy.
Saudi Med J
; 2005 Aug;26(8):1228-30
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The study
was carried out at Al-
Ain
Medical District, United Arab Emirates, between August 2004 and December 2004.
The difference in cesarean section rate was
not
statistically significant.
Observers'
interpretation and
cCTG did
not
correlate well with Apgar score at 5 minutes and admission to special care baby unit.
[MeSH-minor]
Adult.
Diagnosis
, Computer-Assisted. Female. Humans. Infant, Newborn. Predictive
Value of
Tests. Pregnancy. Pregnancy Outcome
Genetic Alliance.
consumer health - Pregnancy
.
MedlinePlus Health Information.
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.
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.
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(PMID = 16127519.001).
[ISSN]
0379-5284
[Journal-full-title]
Saudi medical journal
[ISO-abbreviation]
Saudi Med J
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Saudi Arabia
40.
Chin-Hong PV, Berry JM, Cheng SC, Catania JA, Da Costa M, Darragh TM, Fishman F, Jay N, Pollack LM, Palefsky JM:
Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men.
Ann Intern Med
; 2008 Sep 2;149(5):300-6
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[Title]
Comparison
of patient
- and clinician-collected
anal
cytology samples to screen for human papillomavirus-associated
anal intraepithelial neoplasia
in men who have sex with men.
BACKGROUND: Human papillomavirus (HPV)-associated
anal
cancer is increasing in prevalence and is more common among men who have sex with men and HIV-positive individuals than cervical cancer is among women in the United States.
Cytology screening can detect the
anal
cancer precursor,
anal intraepithelial neoplasia
(
AIN
).
Little is known about self-collected samples for
AIN
screening, and few community-based
AIN
estimates exist.
OBJECTIVE: To compare the sensitivity of self-collected versus clinician-collected
anal
cytology specimens to detect biopsy-confirmed
AIN and
the prevalence estimate
of AIN
in a community sample.
DESIGN: Cross-sectional
study
.
Participants were mailed
anal
cytology self-collection kits with instructions.
Clinicians repeated
anal
cytology and performed high-resolution anoscopy with biopsies as
the diagnostic
reference standard.
MEASUREMENTS: Prevalence of
anal
HPV
and AIN
.
Sensitivity and specificity of self-collected and clinician-collected
anal
cytology specimens to
diagnose AIN
were calculated.
RESULTS: Biopsy-proven
AIN
was
diagnosed in
57% of HIV-positive and 35% of HIV-negative participants (P = 0.
04
), and 80% provided adequate self-collected specimens for
interpretation
.
The sensitivity of cytology to detect
AIN in
HIV-positive men was 75% (95% CI, 51% to 93%) when self-collected and 90% (CI, 68% to 99%) when clinician-collected; respective values in HIV-negative men were 48% (CI, 26% to 70%) and 62% (CI, 38% to 82%).
The specificity of cytology to detect
AIN in
HIV-positive men was 50% (CI, 22% to 78%) when self-collected
and 64
% (CI, 36% to 86%) when clinician-collected; respective values in HIV-negative men were 86% (CI, 71% to 94%) and 85% (CI, 72% to 93%).
LIMITATIONS:
The study
sample was from a narrowly defined geographical area.
CONCLUSION: In a community-based sample, a high proportion of HIV-positive and HIV-negative men who have sex with men have
AIN
.
The sensitivity of cytology to detect
AIN
is higher for clinician-collected versus self-collected specimens and for HIV-positive versus HIV-negative men.
The specificity of cytology to detect
AIN
is higher in HIV-negative versus HIV-positive men.
However, the probability
of AIN
in a
patient
with a negative cytology result
may not
be low enough (23% for HIV-negative men and 45% for HIV-positive men with a
patient
-collected specimen) for clinicians to be comfortable recommending no anoscopy for those with a negative cytology result if done as a one-
time
test.
Given limited resources and the limited
number of
clinicians trained in anoscopy, cytology screening may be the best current approach to identifying
disease in
the at-risk population.
[MeSH-major]
Anus
Neoplasms / pathology. Carcinoma in Situ / pathology. Cytological Techniques / methods. Homosexuality. Papillomavirus Infections / pathology. Specimen Handling / methods
[MeSH-minor]
Adult. Aged.
Anal
Canal
/ pathology. Biopsy. Endoscopy, Gastrointestinal. HIV Seronegativity. HIV Seropositivity / epidemiology. HIV Seropositivity / pathology. HIV Seropositivity / virology. Humans. Male. Middle Aged. Prevalence. San Francisco / epidemiology. Sensitivity and Specificity
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[CommentIn]
Ann Intern Med. 2009 Feb 17;150(4):283-4; author reply 284-5
[
19221387.001
]
[SummaryForPatientsIn]
Ann Intern Med. 2008 Sep 2;149(5):I38
[
18765696.001
]
(PMID = 18765699.001).
[ISSN]
1539-3704
[Journal-full-title]
Annals of internal medicine
[ISO-abbreviation]
Ann. Intern. Med.
[Language]
eng
[Grant]
United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NIAID NIH HHS / AI / K23 AI054157; United States / NIAID NIH HHS / AI / R01 CA/AI 88739; United States / NCI NIH HHS / CA / R01 CA54053; United States / NIMH NIH HHS / MH / R01 MH54320
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
41.
Moscicki AB, Schiffman M, Kjaer S, Villa LL:
Chapter 5: Updating the natural history of HPV and anogenital cancer.
Vaccine
; 2006 Aug 31;24 Suppl 3:S3/42-51
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The major steps in cervical carcinogenesis include infection of the metaplastic epithelium of the cervical transformation
zone
with one or more of the 12-18 carcinogenic types of human papillomavirus (HPV) infection, viral persistence, clonal progression of the persistently-infected epithelium to cervical precancer, and invasion.
The importance of the transformation
zone in
cervical cancer has been extended to other HPV-induced cancers such as
anal
or tonsillar cancers.
Natural history studies show that HPV with normal cervical cytology and cervical
intraepithelial neoplasia
(CIN) grade 1 behave similarly, with the majority of both showing regression.
Whether equivalent lesions
diagnosed
later differ in their natural history remains unknown.
[MeSH-major]
Anus
Neoplasms / virology. Genital Neoplasms, Female / virology. Genital Neoplasms, Male / virology. Neoplasms / virology. Papillomavirus Infections / complications
[MeSH-minor]
Age Factors. Female. Humans. Male. Papillomaviridae /
classification
. Papillomaviridae / isolation & purification.
Time
Factors. United States
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(PMID = 16950017.001).
[ISSN]
0264-410X
[Journal-full-title]
Vaccine
[ISO-abbreviation]
Vaccine
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / R37 CA051323
[Publication-type]
Journal Article; Review
[Publication-country]
Netherlands
[Number-of-references]
45
42.
Wiley DJ, Huh J, Rao JY, Chang C, Goetz M, Poulter M, Masongsong E, Chang CI, Bernard HU:
Methylation of human papillomavirus genomes in cells of anal epithelia of HIV-infected men.
J Acquir Immune Defic Syndr
; 2005 Jun 1;39(2):143-51
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[Title]
Methylation of human papillomavirus genomes in cells of
anal
epithelia of HIV-infected men.
Intra
-
anal
malignancies disproportionately affect individuals who engage in
anal
intercourse because of infection with human papillomaviruses (HPVs), with an increased risk attributed to infection with HIV because of a declining immunity against HPvs. Long-term persistence of HPVs suggests yet other mechanisms that determine the clinical outcome, however.
Because methylation of HPV DNA represses oncogene expression in cervical samples, we investigated whether this mechanism also occurs in HIV-positive men and studied the methylation of CpG dinucleotides overlapping with the HPV-16 enhancer and promoter in 16
anal
samples.
In low-grade
anal intraepithelial neoplasia
(
AIN
), methylation was high in CpGs overlapping the viral enhancer but rare in promoter positions, whereas methylation was high in promoter regions in high-grade
AIN
, especially in samples with a high load of viral genomes.
We also detected
de
novo methylation at methylated (me) CpA, meCpT, and meCpC dinucleotides.
Our
study
expands the observation and mapping of HPV DNA methylation to
anal
infections and the HIV-positive
patient
population.
DNA methylation, taken together with virus load, may be useful to
diagnose the
emergence of a population
of tumor
cells.
[MeSH-minor]
Anal
Canal
/ virology. Base Sequence. Biopsy. DNA Primers. DNA, Viral / genetics. DNA, Viral / isolation & purification. Dinucleoside Phosphates / analysis. Enhancer Elements, Genetic. Homosexuality, Male. Humans. Male. Polymerase Chain Reaction. Virus Latency. Virus Replication
Genetic Alliance.
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.
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.
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(PMID = 15905729.001).
[ISSN]
1525-4135
[Journal-full-title]
Journal of acquired immune deficiency syndromes (1999)
[ISO-abbreviation]
J. Acquir. Immune Defic. Syndr.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA-91964; United States / NCI NIH HHS / CA / R01 CA-91964
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA Primers; 0 / DNA, Viral; 0 / Dinucleoside Phosphates; 2382-65-2 / cytidylyl-3'-5'-guanosine
43.
Hefny AF, Ahmed I, Branicki FJ, Ramadan K, Czechowski J, Abu-Zidan FM:
Management of mesenteric vascular occlusion.
Singapore Med J
; 2008 Apr;49(4):316-9
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INTRODUCTION: The aim of this
study
was to evaluate our recent clinical management of mesenteric vascular occlusion (MVO) at Al-
Ain
Hospital, United Arab Emirates.
METHODS: A retrospective
study
was performed including all patients who were
diagnosed
to have MVO from December 2001 to May 2005.
The records were studied with regard to clinical features, risk factors,
diagnosis
, treatment, and outcome.
The main risk factor for MAO was ischaemic heart
disease
with atrial fibrillation in four patients (80 percent).
No predisposing factors were identified in three patients with MVT (
primary
MVT 43 percent).
Contrast-enhanced computed tomography was performed in all patients and was
diagnostic in
12 (86 percent) patients.
One
patient
died on the ninth postoperative day (overall mortality rate 7 percent).
CONCLUSION: Early
diagnosis
and prompt initiation of anticoagulation therapy, with operative intervention when indicated, are essential for a favourable outcome.
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(PMID = 18418524.001).
[ISSN]
0037-5675
[Journal-full-title]
Singapore medical journal
[ISO-abbreviation]
Singapore Med J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Singapore
[Chemical-registry-number]
0 / Anticoagulants
44.
Bakr IM, Ismail NA:
Domestic violence among women attending out-patient clinics in Ain Shams University Hospitals, Cairo, Egypt.
J Egypt Public Health Assoc
; 2005;80(5-6):629-50
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[Title]
Domestic violence among women attending out-
patient
clinics
in Ain
Shams University Hospitals, Cairo, Egypt.
A descriptive cross sectional
study
was conducted to determine the prevalence of domestic violence among ever married females presenting to out
patient
clinics
in Ain
Shams university hospitals and to identify factors affecting it.
Out of a total
number of
509 women, 89.8% had experienced one or more episodes of violent behavior by their husbands of which 56%, 88.4% and 47.9% suffered physical, control and threat violence.
The most common form of violence among
the study group
was husband's shouting followed by being kept short of money.
This proposes the importance of effective screening,
diagnosis
and management of domestic violence victims.
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(PMID = 17187746.001).
[ISSN]
0013-2446
[Journal-full-title]
The Journal of the Egyptian Public Health Association
[ISO-abbreviation]
J Egypt Public Health Assoc
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Egypt
45.
Al-Maskari F, El-Sadig M:
Prevalence of risk factors for diabetic foot complications.
BMC Fam Pract
; 2007;8:59
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The aim of this
study
was to determine the prevalence and risk factors for foot complications among diabetic patients in Al-
Ain
district, United Arab Emirates (UAE).
METHODS:
The study
was part of a general cross-sectional survey carried out to assess the prevalence of DM complications in Al-
Ain
district, UAE.
All completed an interviewer-administered questionnaire and underwent medical assessment including foot examination and assessment of presence of peripheral neuropathy (PN) and peripheral vascular
disease
(PVD).
RESULTS: Forty nine percent of the
study
populations were
diagnosed
to have DM without presenting with symptoms of diabetes and 35% had hypertension.
There were no cases of amputation and only one
case
had previous history
of lower
extremity ulceration.
Significant risk factors for PN and PVD were: male gender, poor
level of
education, UAE nationality, increased duration of diabetes, type 2 DM, presence of hypertension and microalbuminuria (MA).
CONCLUSION: Despite the low prevalence of foot ulceration and amputation among
the study
population, nevertheless, a substantial proportion had potential risk factors for foot complications.
[MeSH-minor]
Adult. Aged. Albuminuria / complications. Albuminuria / epidemiology. Cross-Sectional Studies. Educational Status. Female. Humans. Hypertension / complications. Hypertension / epidemiology. Male. Middle Aged. Peripheral Nervous System
Diseases
/ complications. Peripheral Nervous System
Diseases
/ epidemiology. Peripheral Vascular
Diseases
/ complications. Peripheral Vascular
Diseases
/ epidemiology. Prevalence. Process Assessment (Health Care) / methods. Risk Assessment. Risk Factors. Sex Factors. Surveys and Questionnaires. United Arab Emirates / epidemiology
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(PMID = 17927826.001).
[ISSN]
1471-2296
[Journal-full-title]
BMC family practice
[ISO-abbreviation]
BMC Fam Pract
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC2174471
46.
Afifi AM, Mady GE, Ahmad AA, el-Shar-Kawy ME, Aly AR, Khalil HH:
Pattern of renal diseases among elderly Egyptians patients with acute or chronic renal diseases in Ain Shams University and Nasser Institute Hospitals, Cairo, Egypt.
J Egypt Soc Parasitol
; 2005 Dec;35(3):911-24
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[Title]
Pattern of renal
diseases
among elderly Egyptians patients with acute or chronic renal
diseases in Ain
Shams University and Nasser
Institute
Hospitals, Cairo, Egypt.
This
study
among elderly renal Egyptian patients (n=220) with only 20 of them were subjected to renal biopsy.
Other cardiovascular risk factors and smoking are reported by previous workers to be HS related to renal
diseases
.
Age was significantly related to GFR, BUN and Cr. but sex difference was
not
significantly related to renal
diseases
.
Multiple myeloma, lupus nephritis, vasculitis and hepatitis B were all recorded in few
numbers of
elderly Egyptians.
HCV was more common and more likely to cause renal
diseases
.
Abdomino-pelvic ultrasound was confirmatory to clinical renal
diseases
diagnosis
.
Ultrasound results among the biopsy
group
were confirmatory to clinical
diagnosis
.
[MeSH-major]
Kidney
Diseases
/
diagnosis
. Kidney
Diseases
/ pathology
[MeSH-minor]
Acute
Disease
. Aged. Chronic
Disease
.
Diagnosis
,
Differential
. Egypt / epidemiology. Female. Humans. Kidney Function Tests. Male
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(PMID = 16333899.001).
[ISSN]
1110-0583
[Journal-full-title]
Journal of the Egyptian Society of Parasitology
[ISO-abbreviation]
J Egypt Soc Parasitol
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Egypt
47.
Goldstone SE, Moshier E:
Detection of oncogenic human papillomavirus impacts anal screening guidelines in men who have sex with men.
Dis Colon Rectum
; 2010 Aug;53(8):1135-42
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[Title]
Detection of oncogenic human papillomavirus impacts
anal
screening guidelines in men who have sex with men.
PURPOSE: It has been shown that testing for oncogenic human papillomavirus (HPV+) improves the sensitivity of cytologic
diagnosis
of atypical cells of undetermined significance in the cervix
and anus
, reducing
the number
of patients requiring colposcopy or high-resolution anoscopy.
We endeavored to determine whether HPV testing could predict future high-grade
dysplasia
(high-grade
squamous
intraepithelial
lesions) and modify screening internals.
METHODS: This investigation was conducted via a retrospective chart review of subjects with atypical cells of undetermined significance
anal
cytology, high-resolution anoscopy, and HPV testing.
Of 224 subjects monitored for >2 years, the hazard ratio for developing high-grade
dysplasia
was 77% less for men who have sex with men who never had oncogenic HPV (HPV-) vs those who stayed HPV+ (P < .013).
The hazard ratio for high-grade
dysplasia in
those who were HPV- vs those who became HPV- was
not
different.
Risk of high-grade
dysplasia
was 28% within 6 months of becoming HPV+.
The 3
-year high-grade
dysplasia
risk was 15% and 54% for HPV- vs HPV+ subjects (P = .0006).
Frequency of high-grade
dysplasia in
subjects who remained HPV- with predominantly atypical cells of undetermined significance cytology for 1, 2, or 3 years was 2%, 0% and 0% and was 17%, 0%, and 0% in HIV+ subjects.
Kaplan-Meier analysis for HIV- subjects with HPV- predominantly atypical cells of undetermined significance cytology for 1 year showed <5% incidence of high-grade
dysplasia
at 4 years.
CONCLUSIONS: Change in HPV status can predict the risk of high-grade
dysplasia
.
Subjects with predominantly HPV- atypical cells of undetermined significance cytology for 2 years have a decreased risk of high-grade
dysplasia
.
HPV testing when screening for
anal
dysplasia
could alter screening parameters.
[MeSH-major]
Anus
Neoplasms /
diagnosis
. Homosexuality, Male. Mass Screening / standards. Papillomaviridae / isolation & purification. Papillomavirus Infections /
diagnosis
. Practice Guidelines as Topic.
Tumor
Virus Infections /
diagnosis
[MeSH-minor]
Adult.
Anal
Canal
/ pathology.
Anal
Canal
/ virology. Colonoscopy. Follow-Up Studies. HIV Seropositivity. Humans. Incidence. Male. Precancerous Conditions. Predictive
Value of
Tests. Retrospective Studies. United States / epidemiology
MedlinePlus Health Information.
consumer health - Anal Cancer
.
HIV InSite.
treatment guidelines - Human Herpesvirus-8
.
International Agency for Research on Cancer - Screening Group.
diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers
.
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(PMID = 20628276.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
48.
Klaudel-Dreszler M, Pietrucha B, Skopczynska H, Pac M, Kurenko-Deptuch M, Heropolitanska-Pliszka E, Wolska-Kusnierz B, Maslanka K, Bernatowska E:
[Chronic neutropenia - experience from the Department of Immunology, Children's Memorial Health Institute].
Med Wieku Rozwoj
; 2007 Apr-Jun;11(2 Pt 1):145-52
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[Title]
[Chronic neutropenia - experience from the Department of Immunology, Children's Memorial Health
Institute
].
The
diagnosis
was based on: bone marrow smears, ANC, immunologic investigation.
RESULTS: we established the
diagnosis
of: Kostmann
disease
(KD), cyclic neutropenia (CyN), hyperIgM syndrome (HIGM), Shwachman-Diamond syndrome (SDS), severe chronic neutropenia (SCN) and chronic benign neutropenia (CBN) in: 4, 2, 2, 1, 21 and 20 children respectively.
Due to positive results of tests: MAIGA, GIFT or GAT autoimmune neutropenia of infancy (
AIN
) was confirmed in 7 children.
In 3
infants neutropenia was connected with HCMV- infection and Gancyclovir therapy.
A boy, with the same
diagnosis
, underwent bone marrow transplantation from related
donor
but died from invasive pulmonary aspergillosis.
During observation period all children suffered from
upper
respiratory tract infections, 19 had chronic gingivitis.
Severe infections- bacterial pneumonia, sepsis, severe varicella and measles were observed in 30, 5,
2 and 1 patient
respectively.
2.
AIN
proved to be a mild condition, although ANC decreased below 500.
In this
entity
rHuG-CSF is recommended during severe infections and before surgery.
3. Antibiotic prophylaxis is recommended for children with: KD, CyN, GSD1b, CN
in 1st
year of life, HIGM; in other cases it is considered individually.
[MeSH-major]
Autoantibodies / immunology. Autoimmune
Diseases
/
diagnosis
. Autoimmune
Diseases
/ therapy. Neutropenia /
diagnosis
. Neutropenia / therapy. Neutrophils / immunology
[MeSH-minor]
Adolescent. Anti-Bacterial Agents / therapeutic use. Bone Marrow Transplantation. Child. Child, Preschool. Chronic
Disease
. Female. Granulocyte Colony-Stimulating Factor / therapeutic use. Hospitals. Humans. Infant. Infection /
diagnosis
. Infection / immunology. Infection / therapy. Leukemia /
diagnosis
. Leukemia / immunology. Leukemia / therapy. Leukocyte Count. Male. Poland. Recombinant Proteins. Retrospective Studies. Treatment Failure. Treatment Outcome
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(PMID = 17625284.001).
[Journal-full-title]
Medycyna wieku rozwojowego
[ISO-abbreviation]
Med Wieku Rozwoj
[Language]
pol
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Poland
[Chemical-registry-number]
0 / Anti-Bacterial Agents; 0 / Autoantibodies; 0 / Recombinant Proteins; 143011-72-7 / Granulocyte Colony-Stimulating Factor
49.
Al-Daraji WI, Al-Mahmoud RM, Ilyas M:
Gastric changes following colchicine therapy in patients with FMF.
Dig Dis Sci
; 2008 Aug;53(8):2079-82
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The salient features of this
disease
include brief recurrent episodes of peritonitis, pleuritis, and arthritis, which are usually associated with fever.
Colchicine is highly effective in the treatment of FMF and in preventing the development of recurrent attacks and amyloidosis, and it is essential to make the correct
diagnosis
and institute
daily therapy with colchicine (0.5-0.6 mg bid).
In this
study
, effects of colchicines on the gastrointestinal tract were evaluated in patients with FMF treated with colchicine.
METHODS: Biopsies were reviewed from 43 patients attending
Ain
Shams University Hospital (Egypt) who were
diagnosed
with FMF and treated with colchicine.
This included biopsies from stomach
body
(38), stomach antrum (50), and colon (24).
In addition, gastric biopsies were reviewed from 17 control patients who did
not
have FMF and were
not
on colchicine.
RESULTS: Three patients known to have FMF and on colchicine therapy showed typical histological features of colchicine (metaphase mitoses,
epithelial
pseudoproliferation, mucin depletion, and frequent apoptosis).
These features were seen only in gastric antral biopsies
and not
in colonic biopsies.
None of the control
group
showed the characteristic morphological features of colchicine toxicity.
CONCLUSION: This is
the first
report of histological changes seen in the stomach following colchicine therapy.
In contrast with previous reports, we did
not
find any definitive change in the large intestine.
If these finding are seen histologically, they merit correlation with the clinical
impression and
should
not
be interpreted as toxicity in isolation.
Hazardous Substances Data Bank.
COLCHICINE
.
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[RetractionIn]
Dig Dis Sci. 2009 Dec;54(12):2772
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11908568.001
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9726336.001
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17592559.001
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Nephrol Dial Transplant. 2002 Jul;17 (7):1212-7
[
12105243.001
]
(PMID = 18080195.001).
[ISSN]
0163-2116
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Journal Article; Retracted Publication
[Publication-country]
United States
[Chemical-registry-number]
SML2Y3J35T / Colchicine
50.
Herat A, Whitfeld M, Hillman R:
Anal intraepithelial neoplasia and anal cancer in dermatological practice.
Australas J Dermatol
; 2007 Aug;48(3):143-53; quiz 154-5
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[Title]
Anal intraepithelial neoplasia
and
anal
cancer in dermatological practice.
Anal intraepithelial neoplasia
is considered to be a precursor lesion of invasive
anal
cancer.
Human papillomaviruses are considered to be an important aetiological agent in both
anal intraepithelial neoplasia
and
anal
cancer.
Dermatologists are likely to encounter these conditions among
the differential diagnoses
to be considered in high-risk patients presenting with
perianal and
anal
lesions.
Anal
cancer rates are also increasing among the HIV-infected and HIV-non-infected population.
The successful treatment of
anal intraepithelial neoplasia
may reduce the risk of subsequent development of
anal
cancer.
However, current therapies for
anal intraepithelial neoplasia
may be associated with treatment-related morbidity and are
not
well validated.
It is currently
not
proven that they reduce the likelihood of the development of
anal
cancer.
Nevertheless, screening for
anal intraepithelial neoplasia
is being advocated for high-risk groups and may become standard dermatological care for these patients.
In view of recent developments in the understanding of this condition, this article reviews the current understanding of
anal intraepithelial neoplasia
and its treatment from a dermatological perspective.
[MeSH-major]
Anus
Neoplasms. Carcinoma in Situ. Carcinoma,
Squamous
Cell. Papillomavirus Infections
[MeSH-minor]
Diagnosis
,
Differential
. HIV Infections / complications. Humans. Papillomaviridae / pathogenicity
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(PMID = 17680964.001).
[ISSN]
0004-8380
[Journal-full-title]
The Australasian journal of dermatology
[ISO-abbreviation]
Australas. J. Dermatol.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Australia
[Number-of-references]
115
51.
Abbas A, Yang G, Fakih M:
Management of anal cancer in 2010. Part 1: Overview, screening, and diagnosis.
Oncology (Williston Park)
; 2010 Apr 15;24(4):364-9
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[Title]
Management of
anal
cancer in 2010. Part 1: Overview, screening, and
diagnosis
.
Although
anal
cancer is a rare
disease
, its incidence is increasing in men and women worldwide.
Anal
cancer is generally preceded by high-grade
anal intraepithelial neoplasia
(HGAIN), which is most prevalent in human immunodeficiency virus (HIV)-positive men who have sex with men.
Meta-analysis suggests that 80% of
anal
cancers could be avoided by vaccination against HPV 16/18.
Nearly half of all patients with
anal
cancer present with rectal bleeding.
Pain or sensation of a rectal mass is experienced in 30% of patients, whereas 20% have no
tumor
-specific symptoms.
According to the Surveillance Epidemiology and End Results (SEER) database, 50% of patients with
anal
cancer have
disease
localized to
the anus
, 29% have regional lymph node involvement or direct spread beyond
the primary
, and 12% have metastatic
disease
, while 9% have an unknown
stage
.
Clinical
staging of
anal
carcinoma requires a digital rectal exam and a computed tomography scan of the chest, abdomen, and pelvis.
The 5-year relative survival rates are 80.1% for localized
anal
cancer, 60.7% for regional
disease
, and 29.4% for metastatic
disease
.
Part
2 of
this two-part review will address the treatment of
anal
cancer, highlighting studies of chemoradiation.
[MeSH-major]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / prevention & control. Mass Screening
Genetic Alliance.
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(PMID = 20464850.001).
[ISSN]
0890-9091
[Journal-full-title]
Oncology (Williston Park, N.Y.)
[ISO-abbreviation]
Oncology (Williston Park, N.Y.)
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
94
52.
Mirasoli M, Guardigli M, Simoni P, Venturoli S, Ambretti S, Musiani M, Roda A:
Multiplex chemiluminescence microscope imaging of P16(INK4A) and HPV DNA as biomarker of cervical neoplasia.
Anal Bioanal Chem
; 2009 Jun;394(4):981-7
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[Title]
Multiplex chemiluminescence microscope imaging of P16(INK4A) and HPV DNA as biomarker of cervical
neoplasia
.
Classification of
cervical
intraepithelial neoplasia
(CIN) lesions in low-grade (CIN1) or high-grade (CIN2-3) ones is crucial for optimal
patient
management, but current histological
diagnosis
on bioptic samples is often hampered by
inter
-observer variability.
To allow objective
classification
, we have exploited the peculiar characteristics of chemiluminescence detection, such as high sensitivity and easy quantification of the luminescence signal, to perform sequentially in the same tissue section both an immunohistochemical quantitative detection of p16(INK4A) (a protein marker of high-grade CIN lesions) and an in situ hybridization for human papillomavirus (generally accepted as a necessary but insufficient cause of cervical carcinoma).
The multiplexed method allowed detection of two complementary biomarkers and provided
discrimination
between different lesions (non-neoplastic, low-grade and high-grade CIN).
This assay might thus represent an accurate and objective
diagnostic
test providing important information for counseling, selection of therapy and follow up after surgical treatment.
[MeSH-major]
Biomarkers,
Tumor
/ analysis. Cervical
Intraepithelial Neoplasia
/
diagnosis
. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA, Viral / analysis. Luminescent Measurements / methods. Papillomaviridae / genetics. Papillomaviridae / isolation & purification
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(PMID = 19263042.001).
[ISSN]
1618-2650
[Journal-full-title]
Analytical and bioanalytical chemistry
[ISO-abbreviation]
Anal Bioanal Chem
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral
53.
Jawas A, Abu-Zidan FM:
Management algorithm for complete blunt renal artery occlusion in multiple trauma patients: case series.
Int J Surg
; 2008 Aug;6(4):317-22
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[Title]
Management algorithm for complete blunt renal artery occlusion in multiple trauma patients:
case
series.
OBJECTIVE: To
study the
management of complete renal artery occlusion in multiple trauma patients so as to develop a management algorithm.
DESIGN: Retrospective
study
.
PATIENTS AND METHODS: All blunt trauma patients who had complete renal artery occlusion and were treated at Tawam and Al-
Ain
Hospitals during 2005-2007 were studied.
Three had the injury on the right side while two on
the left
side.
The kidney was
left in
situ in one
patient
who underwent
damage
control laparotomy.
An attempted renal artery repair was aborted due to haemo-dynamic instability in another
patient
.
One
patient
developed hypertension and had
interval
nephrectomy.
[MeSH-major]
Abdominal Injuries / complications. Algorithms. Arterial Occlusive
Diseases
/ surgery. Renal Artery / injuries. Wounds, Nonpenetrating / complications
[MeSH-minor]
Adolescent. Adult. Angiography / methods. Child. Cohort Studies. Female. Follow-Up Studies. Humans. Injury Severity Score. Male. Multiple Trauma /
diagnosis
. Multiple Trauma / mortality. Multiple Trauma / therapy. Registries. Retrospective Studies. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome. United Arab Emirates. Vascular Surgical Procedures / methods
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(PMID = 18590988.001).
[ISSN]
1743-9159
[Journal-full-title]
International journal of surgery (London, England)
[ISO-abbreviation]
Int J Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
54.
Devaraj B, Cosman BC:
Expectant management of anal squamous dysplasia in patients with HIV.
Dis Colon Rectum
; 2006 Jan;49(1):36-40
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[Title]
Expectant management of
anal
squamous dysplasia
in patients with HIV.
PURPOSE:
Anal
squamous dysplasia
is commonly found in patients with HIV infection.
This
study
reviews a series of patients with HIV and an abnormal
anal
examination who had
squamous dysplasia
and who have been followed with physical examination alone and with repeat biopsies as necessary for new or suspicious lesions.
METHODS: We reviewed the charts of 40 HIV-positive men who had
squamous dysplasia
of the
anal
canal and
anal
margin
, focusing on history, physical findings, histologic
diagnosis
, and the occurrence of invasive
squamous
-cell carcinoma.
RESULTS: Forty HIV-positive men (mean age, 39 years) were followed for
anal
squamous dysplasia
.
Biopsies revealed
dysplasia
, which was usually multifocal.
The grade
of dysplasia
varied, but 28 of 40 patients had at least one area of severe
dysplasia
.
CONCLUSIONS: Extensive excision for
dysplasia in
the context of HIV confers high morbidity and questionable benefit, and other treatments are of uncertain
value
.
In a
group of
patients followed expectantly, most did
not
develop invasive cancer, and in those who did, early cancers could be identified and cured.
Physical examination surveillance for invasive carcinoma may be acceptable for following patients with HIV and biopsy-proven
squamous dysplasia
.
[MeSH-major]
Anus
Neoplasms / surgery. Carcinoma,
Squamous
Cell / surgery. Colectomy / methods. Decision Making. HIV / immunology. HIV Antibodies / immunology. HIV Infections / complications
[MeSH-minor]
Adult. Biopsy.
Disease
Progression. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies.
Time
Factors
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HIV InSite.
treatment guidelines - Human Herpesvirus-8
.
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[CommentIn]
Dis Colon Rectum. 2006 Oct;49(10):1648-9; author reply 1649-50
[
16972138.001
]
(PMID = 16283561.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Case Reports; Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / HIV Antibodies
55.
Praga M, González E:
Acute interstitial nephritis.
Kidney Int
; 2010 Jun;77(11):956-61
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Acute interstitial nephritis (
AIN
) represents a frequent cause of acute kidney injury, accounting for 15-27% of renal biopsies performed because of this condition.
By and large, drug-induced
AIN
is currently the commonest etiology
of AIN
, with antimicrobials and nonsteroidal anti-inflammatory drugs being the most frequent offending agents.
Pathogenesis is based on an immunologic reaction against endogenous nephritogenic
antigens
or exogenous
antigens
processed by tubular cells, with cell-mediated immunity having a major pathogenic role.
A significant proportion
of AIN
has nowadays an oligosymptomatic presentation, although the presence of specific extrarenal symptoms such as fever, skin rash, arthralgias, and peripheral eosinophilia has an important role to orientate clinical
diagnosis
.
Identification and removal of the offending drug are the mainstay of the treatment, but recent studies strongly suggest that early steroid administration (within 7 days after
diagnosis
) improves the recovery of renal function, decreasing the risk of chronic renal impairment.
[MeSH-minor]
Acute
Disease
. Animals.
Disease
Progression. Humans. Predictive
Value of
Tests. Recovery of Function. Risk Factors. Steroids / therapeutic use.
Time
Factors. Treatment Outcome
The Weizmann Institute of Science GeneCards and MalaCards databases.
gene/protein/disease-specific - MalaCards for interstitial nephritis
.
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[CommentIn]
Kidney Int. 2011 Jan;79(1):137-8; author reply 138
[
21157464.001
]
(PMID = 20336051.001).
[ISSN]
1523-1755
[Journal-full-title]
Kidney international
[ISO-abbreviation]
Kidney Int.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Steroids
[Number-of-references]
34
56.
Herat A, Shirato K, Damian DL, Finlayson R, Whitfeld M:
Invasive squamous cell carcinoma arising in refractory perianal Bowen's disease in a HIV-positive individual.
Australas J Dermatol
; 2006 May;47(2):120-3
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[Title]
Invasive
squamous
cell carcinoma arising in refractory
perianal
Bowen's
disease in
a HIV-positive individual.
A 54-year-old HIV-positive homosexual man presented with erythematous and pigmented plaques on background erythema in the
perianal
region, histologically consistent with Bowen's
disease
.
Perianal
Bowen's
disease
represents high-grade
anal intraepithelial neoplasia
, which is considered a precursor lesion of invasive
anal
squamous
cell carcinoma.
This
patient
's
anal intraepithelial neoplasia
was unresponsive to multiple treatment modalities including cryotherapy, serial curettage and cautery, topical 5-fluorouracil and 5-aminolaevulinic
acid
photodynamic therapy.
He progressed to develop a poorly differentiated
squamous
cell carcinoma of the
anus
three and a half years after the Bowen's
disease
was
diagnosed
.
The squamous
cell carcinoma was treated with combined chemoradiation.
A recurrence of high-grade
anal intraepithelial neoplasia
was noted 6 months after completion of chemoradiation.
[MeSH-major]
Bowen's
Disease
/
diagnosis
. Carcinoma,
Squamous
Cell /
diagnosis
. HIV Infections. Neoplasm Recurrence, Local /
diagnosis
. Skin Neoplasms /
diagnosis
[MeSH-minor]
Anal
Canal
. Combined Modality Therapy.
Diagnosis
,
Differential
. Homosexuality, Male. Humans. Male. Middle Aged. Neoplasm Invasiveness
Genetic Alliance.
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.
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(PMID = 16637809.001).
[ISSN]
0004-8380
[Journal-full-title]
The Australasian journal of dermatology
[ISO-abbreviation]
Australas. J. Dermatol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
57.
Wahl RU, Blazek C, Megahed M:
[HPV type 16-associated anal intraepithelial neoplasia (AIN)].
Hautarzt
; 2009 May;60(5):371-2
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[Title]
[HPV type 16-associated
anal intraepithelial neoplasia
(
AIN
)].
[Transliterated title]
HPV-Typ-16-assoziierte
anale intraepitheliale Neoplasie
(
AIN
).
A 25-year-old woman had suffered from a
perianal
ulcer for approximately 1 year.
Employing virologic and histologic techniques, we confirmed the
diagnosis
of an
intraepithelial neoplasia
.
Anal intraepithelial neoplasia
(
AIN
) is induced by carcinogenic human papillomaviruses.
Because of its frequency,
AIN
is a crucial
differential
diagnosis
for lesions of the anogenital area region failing to respond to standard therapies.
[MeSH-major]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / surgery. Carcinoma in Situ /
diagnosis
. Carcinoma in Situ / surgery. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections /
diagnosis
. Papillomavirus Infections / surgery. Skin Neoplasms /
diagnosis
. Skin Neoplasms / surgery
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.
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.
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[Cites]
Gynecol Oncol. 2008 Sep;110(3 Suppl 1):S18-25
[
18653221.001
]
[Cites]
Cancer. 2008 Oct 1;113(7 Suppl):1980-93
[
18798536.001
]
[Cites]
Cases J. 2008 Aug 20;1(1):114
[
18715505.001
]
[Cites]
Vaccine. 2008 Nov 18;26(49):6244-57
[
18694795.001
]
[Cites]
N Z Med J. 2007 Nov 30;120(1266):U2829
[
18264198.001
]
[Cites]
AIDS. 2009 Jan 2;23(1):59-70
[
19050387.001
]
[Cites]
J Sex Med. 2009 Mar;6(3):633-45
[
19170869.001
]
[Cites]
Int J STD AIDS. 2008 Jul;19(7):445-9
[
18574114.001
]
(PMID = 19430747.001).
[ISSN]
1432-1173
[Journal-full-title]
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
[ISO-abbreviation]
Hautarzt
[Language]
ger
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Germany
58.
Chung AP, Rosenfeld DB:
Intraoperative high-resolution anoscopy: a minimally invasive approach in the treatment of patients with Bowen's disease and results in a private practice setting.
Am Surg
; 2007 Dec;73(12):1279-83
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[Title]
Intraoperative high-resolution anoscopy: a minimally invasive approach in the treatment of patients with Bowen's
disease and
results in a private practice setting.
Anal intraepithelial neoplasia
III (
AIN
III) is a risk factor for
anal
cancer with poor curative results and high morbidity.
High-resolution anoscopy (HRA) is a minimally invasive means of identifying and treating
AIN
III early.
We retrospectively reviewed HRA in the treatment
of AIN
III in a community setting.
From January 2002 through November 2005, 76 patients with
AIN
III
diagnosed
by
anal
Pap smear, colposcopy, or biopsy underwent HRA for
diagnosis
and treatment.
Twenty-one patients with
AIN
III on initial HRA underwent follow-up HRA for reassessment and treatment at 6 months.
Recurrence/persistence
of disease
was recorded and compared with
patient
characteristics.
Twelve of 21 (57%) had intraanal recurrence/persistence; nine of 21 (43%) had no
AIN
III.
Three (75%) HIV-negative patients had no recurrence/persistence; one of four (25%) had recurrence; and 11 of 17 (65%) HIV-positive patients had persistence
of disease
.
HRA is an alternative tool to treat
AIN
III and can be performed in a community setting yielding results comparable to the university setting.
As the prevalence
of AIN
III increases, it will be more important for community surgeons to treat
AIN
III with HRA.
[MeSH-major]
Bowen's
Disease
/ pathology. Bowen's
Disease
/ surgery. Endoscopy, Gastrointestinal / methods. Skin Neoplasms / pathology. Skin Neoplasms / surgery
[MeSH-minor]
Adult. Aged.
Anal
Canal
. Community Health Services. Follow-Up Studies. Humans. Male. Middle Aged. Private Practice. Retrospective Studies. Treatment Outcome
Genetic Alliance.
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consumer health - Skin Cancer
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(PMID = 18186390.001).
[ISSN]
0003-1348
[Journal-full-title]
The American surgeon
[ISO-abbreviation]
Am Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
59.
Nahas CS, Lin O, Weiser MR, Temple LK, Wong WD, Stier EA:
Prevalence of perianal intraepithelial neoplasia in HIV-infected patients referred for high-resolution anoscopy.
Dis Colon Rectum
; 2006 Oct;49(10):1581-6
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[Title]
Prevalence
of perianal
intraepithelial neoplasia
in HIV-infected patients referred for high-resolution anoscopy.
PURPOSE: This
study
was designed to describe
perianal disease
in a cohort of HIV-infected patients referred for high-resolution anoscopy.
All patients underwent
anal
canal and perianal
high-resolution anoscopy in the office with biopsy of suspicious areas.
Patients with high-grade
intraepithelial
perianal
lesions underwent multiple biopsies under general anesthesia in the operating room to rule out malignancy.
RESULTS: Of the 52 patients, 19 (37 percent) had
perianal
abnormalities noted on high-resolution anoscopy and underwent punch biopsy.
Office
perianal
biopsies
diagnosed
two patients with invasive
squamous
-cell carcinoma and nine with high-grade
squamous
intraepithelial
lesion.
Seven of the nine patients with
perianal
high-grade
squamous
intraepithelial
lesion on office biopsy were submitted to multiple biopsies under general anesthesia.
One of these seven had an occult
perianal squamous
-cell carcinoma.
CONCLUSIONS:
Perianal disease
was common in this
group of
HIV-infected patients; 11 patients (21 percent of total) were
diagnosed
with
squamous
-cell carcinoma or high-grade
squamous
intraepithelial
lesion.
Because only 19 patients had clinically suspicious
perianal
lesions biopsied, this may be an underestimate.
Our data suggest that
anal
canal
neoplasia
often is accompanied by
perianal disease
and illustrates the need for biopsy of any suspicious
perianal
lesions.
[MeSH-major]
Anus
Neoplasms / etiology. Carcinoma in Situ / etiology. Carcinoma,
Squamous
Cell / epidemiology. HIV Infections / complications. Proctoscopy / methods
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(PMID = 16977374.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
60.
Esteve JB, Launay-Vacher V, Brocheriou I, Grimaldi A, Izzedine H:
COX-2 inhibitors and acute interstitial nephritis: case report and review of the literature.
Clin Nephrol
; 2005 May;63(5):385-9
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[Title]
COX-2 inhibitors and acute interstitial nephritis:
case
report and review of the literature.
We report a
case of
biopsy-proven acute interstitial nephritis (
AIN
) in a 50-year-old diabetic woman, who had been treated with celecoxib for 4 weeks before presentation.
A kidney biopsy specimen showed
AIN
with intense tubuli and eosinophilic infiltrate in the interstitium.
A review of the literature yielded eight cases of COX-2 inhibitor-associated
AIN
with a biopsy-proven
diagnosis
.
Among the reported cases,
AIN
was
diagnosed
after an average of 8.3 months of therapy (SD 12 months, range 3 days - 3 years) with 25 mg rofecoxib or 200 mg celecoxib daily.
Renal failure was common at
the time
of
diagnosis
.
Mean serum creatinine levels were 0.86 +/- 0.11 mg/dl, 5.66 +/- 3.50 mg/dl
and 1
.15 +/- 0.24 before treatment, at
time of
diagnosis
and 1
- 2 months after COX-2 inhibitor withdrawal, respectively.
After cessation of COX-2 inhibitor treatment, patients recovered completely with a normalized serum creatinine
level
after one to two months.
[MeSH-minor]
Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Kidney Function Tests. Middle Aged. Prednisolone / therapeutic use. Risk Assessment. Severity of Illness
Index
. Treatment Outcome
Hazardous Substances Data Bank.
PREDNISOLONE
.
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(PMID = 15909599.001).
[ISSN]
0301-0430
[Journal-full-title]
Clinical nephrology
[ISO-abbreviation]
Clin. Nephrol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Review
[Publication-country]
Germany
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase Inhibitors; 9PHQ9Y1OLM / Prednisolone
[Number-of-references]
25
61.
Silva MA, Ataide Tda R, Oliveira SL, Sant'ana AE, Cabral Júnior CR, Balwani Mdo C, de Oliveira FG, Santos MC:
[Hepatoprotective effect of diheptanoin and tritreptanoin chronic consumption against steatosis in rats].
Arq Bras Endocrinol Metabol
; 2008 Oct;52(7):1145-55
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[Transliterated title]
Efeito hepatoprotetor do consumo crônico
de
dieptanoína e trieptanoína contra a esteatose em ratos.
OBJECTIVE: To evaluate the effect of chronic consumption
of di
- and triheptanoin on hepatic steatosis (HS) in rats.
METHODOLOGY: Wistar rats were submitted to a diet
AIN
-93 with 0, 30 or 50% of its oil substituted with an oil rich
in di
- and triheptanoin, groups TAGC(7)0, TAGC(7)30 and TAGC(7)50 respectively, for nine months.
The control
group
received Labina(R).
The experimental oil reduced RLW and showed a tendency in the reduction
of body
weight, ALW, percentage of hepatic lipids and the severity of HS.
CONCLUSIONS: It is suggested that
di
- and triheptanoin have a hepatoprotector effect against HS, in rats, in a
dose
-dependent manner.
[MeSH-major]
Cholesterol /
blood
. Diglycerides / administration & dosage. Fatty Liver / prevention & control. Triglycerides / administration & dosage
[MeSH-minor]
Analysis of Variance. Animals.
Blood
Glucose / analysis. Kidney / pathology. Lipids /
blood
. Male. Rats. Rats, Wistar. Regression Analysis
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CHOLESTEROL
.
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[CommentIn]
Arq Bras Endocrinol Metabol. 2010 Aug;54(6):584-7
[
20857067.001
]
(PMID = 19082303.001).
[ISSN]
1677-9487
[Journal-full-title]
Arquivos brasileiros de endocrinologia e metabologia
[ISO-abbreviation]
Arq Bras Endocrinol Metabol
[Language]
por
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Brazil
[Chemical-registry-number]
0 / Blood Glucose; 0 / Diglycerides; 0 / Lipids; 0 / Triglycerides; 2P6O7CFW5K / triheptanoin; 97C5T2UQ7J / Cholesterol
62.
Zawislak AA, Price JH, Dobbs SP, McClelland HR, McCluggage WG:
the management of vulval intraepithelial neoplasia in Northern Ireland.
Int J Gynecol Cancer
; 2006 Mar-Apr;16(2):780-5
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[Title]
the management of vulval
intraepithelial neoplasia
in Northern Ireland.
In this
study
, we present the findings of a regional retrospective audit of all cases of vulval
intraepithelial neoplasia
(VIN)
diagnosed in
Northern Ireland (NI) over an 11-year period (1989-1999).
During the period of the
study
, there were 97 cases of VIN.
The most common histopathologic
diagnosis
was VIN III (73%).
In 52% of the cases, there was multifocal VIN, and in 43%, there was involvement of other sites such as the cervix, vagina, or
anal
region.
During
the study
period, 18 of 90 patients (20%) for whom follow-up was available developed invasive vulval
squamous
carcinoma.
Most of the vulval cancers were superficially invasive, but three patients died of vulval cancer during
the study
period.
This
study
illustrates that in NI, VIN is treated at many institutions by a multitude of clinicians.
VIN should be managed by clinicians with expertise in this field and who are treating significant
numbers of
patients according to evidence-based protocols.
[MeSH-major]
Carcinoma in Situ / therapy. Carcinoma,
Squamous
Cell / therapy. Neoplasm Recurrence, Local / pathology. Vulvar Neoplasms / therapy
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Combined Modality Therapy.
Disease
-Free Survival. Female. Follow-Up Studies. Humans. Medical Audit. Middle Aged. Neoplasm
Staging
. Northern Ireland / epidemiology. Retrospective Studies. Survival Rate. Treatment Outcome
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(PMID = 16681760.001).
[ISSN]
1048-891X
[Journal-full-title]
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
[ISO-abbreviation]
Int. J. Gynecol. Cancer
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
63.
Shepherd NA:
Anal intraepithelial neoplasia and other neoplastic precursor lesions of the anal canal and perianal region.
Gastroenterol Clin North Am
; 2007 Dec;36(4):969-87, ix
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[Title]
Anal intraepithelial neoplasia
and other neoplastic precursor lesions of the
anal
canal and perianal
region.
Anal
cancer is rare and this helps to explain why
anal
pre-neoplastic conditions are poorly understood, especially with regard to their natural history and management.
Anal intraepithelial neoplasia
is closely linked to human papillomavirus infection and is particularly common in homosexuals and in immunosuppressed patients, especially those with HIV/AIDS.
The high regression rates of low-grade
anal intraepithelial neoplasia
may simply reflect inconsistent pathologic reporting.
Higher grades of
anal intraepithelial neoplasia
may remain static for long periods
of time
in immunocompetent patients, but those with HIV/AIDS show early and rapid malignant transformation.
In general, most
anal
pre-neoplastic conditions are best
diagnosed
by biopsy and treated by surgical excision, although local recurrence is a problem.
In
anal
Paget's
disease
, it is important to ascertain, at
the time
of
diagnosis
, whether it is due to a
primary in
-situ apocrine-type of
neoplasia
of the
anus
or if
the disease
is secondary to an invasive
primary
carcinoma of the rectum.
[MeSH-minor]
Anal
Canal
.
Diagnosis
,
Differential
. Humans
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(PMID = 17996800.001).
[ISSN]
0889-8553
[Journal-full-title]
Gastroenterology clinics of North America
[ISO-abbreviation]
Gastroenterol. Clin. North Am.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
119
64.
Geevasinga N, Coleman PL, Webster AC, Roger SD:
Proton pump inhibitors and acute interstitial nephritis.
Clin Gastroenterol Hepatol
; 2006 May;4(5):597-604
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Although well-tolerated, there have been
case
reports and a recent
case
series implicating these drugs in acute interstitial nephritis (
AIN
) and progression to acute renal failure (ARF).
The aim of this
study
was to investigate how widespread this complication is in Australia, to identify which PPIs are implicated, and to establish whether PPI-induced
AIN
is a class effect.
METHODS: We undertook a retrospective
case
review of potential cases at 2 teaching hospitals and a review of registry data from the Therapeutic Goods Administration of Australia (TGA).
Parameters sought included the drug implicated, concurrent medications, symptoms, signs, serum creatinine,
and time
of onset after prescription.
RESULTS: We identified 18 cases of biopsy-proven PPI-induced
AIN
causing ARF in the retrospective
case
review, which is the largest hospital-based
case
series to date.
CONCLUSION: With the ever more widespread use of this class of medications, PPI-induced
AIN
is likely to become more frequent.
Failure to recognize this
entity
might have catastrophic long-term consequences including chronic kidney
disease
.
Increased awareness might facilitate more rapid
diagnosis
and management of this potentially reversible condition.
[MeSH-minor]
2-Pyridinylmethylsulfinylbenzimidazoles. Adult. Age Distribution. Aged. Aged, 80 and over. Australia. Benzimidazoles / adverse effects. Benzimidazoles / therapeutic use. Dyspepsia /
diagnosis
. Dyspepsia / drug therapy. Education, Medical, Continuing. Female. Gastroesophageal Reflux /
diagnosis
. Gastroesophageal Reflux / drug therapy. Hospitals, Teaching. Humans. Male. Middle Aged. Omeprazole / adverse effects. Omeprazole / analogs & derivatives. Omeprazole / therapeutic use. Prevalence. Prognosis. Registries. Retrospective Studies. Risk Assessment. Severity of Illness
Index
. Sex Distribution. Sulfoxides / adverse effects. Sulfoxides / therapeutic use
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PANTOPRAZOLE
.
Hazardous Substances Data Bank.
OMEPRAZOLE
.
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[CommentIn]
Clin Gastroenterol Hepatol. 2006 Oct;4(10):1296-7; author reply 1297
[
17045214.001
]
(PMID = 16630752.001).
[ISSN]
1542-3565
[Journal-full-title]
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
[ISO-abbreviation]
Clin. Gastroenterol. Hepatol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / 2-Pyridinylmethylsulfinylbenzimidazoles; 0 / Benzimidazoles; 0 / Enzyme Inhibitors; 0 / Proton Pump Inhibitors; 0 / Sulfoxides; D8TST4O562 / pantoprazole; KG60484QX9 / Omeprazole
65.
Bean SM, Chhieng DC, Roberson J, Raper JL, Broker TR, Hoesley CJ, Eltoum IA, Jin G:
Anal-rectal cytology: correlation with human papillomavirus status and biopsy diagnoses in a population of HIV-positive patients.
J Low Genit Tract Dis
; 2010 Apr;14(2):90-6
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[Title]
Anal
-rectal cytology: correlation with human papillomavirus status and biopsy
diagnoses in
a population of HIV-positive patients.
OBJECTIVES: We describe the cytological distribution
of disease
, correlate cytological
diagnoses
with human papillomavirus (HPV) DNA status and surgical biopsy
diagnoses
, determine if CD4 counts correlate with lesion severity, and compare
anal
-rectal data of HIV-infected patients (primarily men) with cervical data.
MATERIALS AND METHODS: A retrospective search of the computerized database identified 118 HIV-positive patients who had
anal
-rectal cytology.
Cytology results were compared with available follow-up data including repeat
anal
-rectal cytology tests, surgical biopsy, CD4 counts, and HPV DNA polymerase chain reaction-based genotyping.
RESULTS: Cytological
diagnoses
included 3% unsatisfactory for
diagnosis
, 41% negative for
intraepithelial
lesion or malignancy (NILM), 23% atypical
squamous
cells of undermined significance (ASC-US), 31% low-grade
squamous
intraepithelial
lesion (LSIL),
and 2
% high-grade
squamous
intraepithelial
lesion (HSIL) (ASC-US/
squamous
intraepithelial
lesion, 0.7:1).
Two
anal intraepithelial neoplasia
(
AIN
) II, 10
AIN
III,
and 1
invasive
squamous
cell carcinoma were histologically detected (11%).
The majority
of AIN
II was preceded by LSIL, 54%; ASC-US, 15%; and HSIL, 8%.
Sensitivity, specificity, negative predictive
value
, and positive predictive
value
were 92%, 8%, 33%, and 67%, respectively.
Of those HPV tested concurrent with
the first
cytology specimen, 48% NILM, 78% ASC-US, and 100% LSIL were HPV positive.
Mean CD4 counts (per microliter) were
lower in
patients with HSIL (243 [SD, 65]) compared with LSIL (400 [SD, 261]) and NILM (428 [SD, 232]).
CONCLUSIONS:
Anal
-rectal cytology is a useful screening test.
A high percentage
of AIN
II lesions were detected in this at-risk population, and the majority was detected following cytological abnormality.
[MeSH-major]
Anal
Canal
/ pathology. HIV Infections / complications. Papillomaviridae / isolation & purification. Papillomavirus Infections / epidemiology. Rectal Neoplasms / epidemiology. Rectum / pathology
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(PMID = 20354415.001).
[ISSN]
1526-0976
[Journal-full-title]
Journal of lower genital tract disease
[ISO-abbreviation]
J Low Genit Tract Dis
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / CA83679
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
66.
Berry JM, Palefsky JM, Jay N, Cheng SC, Darragh TM, Chin-Hong PV:
Performance characteristics of anal cytology and human papillomavirus testing in patients with high-resolution anoscopy-guided biopsy of high-grade anal intraepithelial neoplasia.
Dis Colon Rectum
; 2009 Feb;52(2):239-47
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[Title]
Performance characteristics of
anal
cytology and human papillomavirus testing in patients with high-resolution anoscopy-guided biopsy of high-grade
anal intraepithelial neoplasia
.
PURPOSE: High-resolution anoscopy is colposcopy of the
anus
after applying 3 percent acetic
acid
.
High-resolution anoscopy with biopsy was used as the standard for detecting high-grade
anal neoplasia
and was compared to detection of high-grade
anal neoplasia
by
anal
cytology, human papillomavirus testing, or the combination.
METHODS: A total of 125 men who have sex with men (MSM) were enrolled from a
group of
MSM identified by random digit dialing: HIV-negative = 85, HIV-positive = 35, and unknown status = 5.
A specimen was taken for
anal
cytology and human papillomavirus testing, followed by high-resolution anoscopy with biopsy of any lesions.
RESULTS: Ninety-one percent of HIV-positive and 57 percent of HIV-negative MSM had
anal
human papillomavirus infection.
In HIV-positive men the sensitivity of abnormal cytology to detect high-grade
anal neoplasia
was 87 percent, and in HIV-negative MSM it was 55 percent.
Among HIV-negative men, 9 of 20 cases of high-grade
anal neoplasia
would have been missed because cytology was negative, but the addition of human papillomavirus positivity increased sensitivity for the combination to 90 percent.
CONCLUSIONS: Sensitivity and specificity of
anal
cytology and human papillomavirus testing are different in HIV-positive and HIV-negative MSM for detecting high-grade
anal neoplasia
when patients have high-resolution anoscopy-guided biopsy of lesions.
High-resolution anoscopy is an effective tool for
diagnosing
high-grade
anal neoplasia
.
[MeSH-major]
Anal
Canal
/ pathology.
Anus
Neoplasms /
diagnosis
. Carcinoma in Situ /
diagnosis
. Endoscopy, Gastrointestinal. Papillomaviridae / isolation & purification. Papillomavirus Infections /
diagnosis
[MeSH-minor]
Adult. Aged.
Anus Diseases
/
diagnosis
.
Anus Diseases
/ virology. Biopsy. Cytodiagnosis. HIV Seronegativity. HIV Seropositivity / complications. Homosexuality. Humans. Male. Middle Aged. Polymerase Chain Reaction. Precancerous Conditions /
diagnosis
. Predictive
Value of
Tests. Sensitivity and Specificity
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(PMID = 19279418.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Grant]
United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NIAID NIH HHS / AI / K23 AI054157; United States / NIAID NIH HHS / AI / R01 CA/AI 88739; United States / NCI NIH HHS / CA / R01 CA54053; United States / NCRR NIH HHS / RR / UL1 RR024131-01
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
67.
Giraldo P, Jacyntho C, Costa C, Iglesias M, Gondim C, Carvalho F, Giraldo H, Gonçalves AK:
Prevalence of anal squamous intra-epithelial lesion in women presenting genital squamous intra-epithelial lesion.
Eur J Obstet Gynecol Reprod Biol
; 2009 Jan;142(1):73-5
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[Title]
Prevalence of
anal
squamous intra
-
epithelial
lesion in women presenting genital
squamous intra
-
epithelial
lesion.
OBJECTIVE: To determine the frequency of
anal
squamous intra
-
epithelial
lesions (ASIL) in women with genital
squamous intra
-
epithelial
lesions (GSIL).
STUDY
DESIGN: In a cross sectional
study
, 184 patients with histopathological
diagnosis
of GSIL and 76 controls without GSIL, were submitted to anuscopy in order to determine the presence of ASIL.
All the women were HIV-negative with
anal
aceto-white lesions were biopsed for histological
diagnosis
.
RESULTS: The frequency of ASIL was 17.4% in the GSIL
group
(3.2% high grade ASIL) and only 2.6% in the control
group
(0% high grade ASIL) (p<0.001).
All the high grade ASIL
diagnoses
were found in women with cervical SIL.
[MeSH-major]
Anus Diseases
/ epidemiology
[MeSH-minor]
Adult. Cervical
Intraepithelial Neoplasia
/ epidemiology. Cross-Sectional Studies. Female. Humans. Muscular
Diseases
/ epidemiology
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(PMID = 19019529.001).
[ISSN]
1872-7654
[Journal-full-title]
European journal of obstetrics, gynecology, and reproductive biology
[ISO-abbreviation]
Eur. J. Obstet. Gynecol. Reprod. Biol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Ireland
68.
Punnose J, Agarwal MM, Bin-Uthman S:
Type 2 diabetes mellitus among children and adolescents in Al-Ain: a case series.
East Mediterr Health J
; 2005 Jul;11(4):788-97
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[Title]
Type 2 diabetes mellitus among children and adolescents in Al-
Ain
: a
case
series.
To characterize the features of type 2 diabetes mellitus among children and adolescents in Al-
Ain
, the records of every child with diabetes attending a teaching hospital in the city from January 1990 to December 2001 were retrospectively examined.
Of 96 young people newly
diagnosed
with diabetes mellitus, 11 were identified as type 2.
This
case
series adds to the evidence that type 2 diabetes mellitus is emerging among children in our region.
[MeSH-major]
Diabetes Mellitus, Type 2 /
diagnosis
. Diabetes Mellitus, Type 2 / epidemiology
[MeSH-minor]
Adolescent. Age of Onset.
Blood
Glucose / metabolism. C-Peptide /
blood
. Child. Epidemiologic Studies. Fasting. Female. Hospitals, Teaching. Hospitals, Urban. Humans. Insulin /
blood
. Insulin Resistance. Islets of Langerhans / immunology. Male. Obesity / complications. Obesity / epidemiology. Pedigree. Puberty. Retrospective Studies. Risk Factors. Sex Distribution. United Arab Emirates / epidemiology
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(PMID = 16700395.001).
[ISSN]
1020-3397
[Journal-full-title]
Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ
[ISO-abbreviation]
East. Mediterr. Health J.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Egypt
[Chemical-registry-number]
0 / Blood Glucose; 0 / C-Peptide; 0 / Insulin
69.
Darvishian F, Stier EA, Soslow RA, Lin O:
Immunoreactivity of p16 in anal cytology specimens: histologic correlation.
Cancer
; 2006 Feb 25;108(1):66-71
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[Title]
Immunoreactivity of p16 in
anal
cytology specimens: histologic correlation.
BACKGROUND: Cytology has been proposed as a potential screening tool in the evaluation
of squamous
anorectal
disease in
view of the morphologic similarities between
anal
and cervical
squamous
lesions.
Previous studies have demonstrated that p16 overexpression correlates with the degree
of dysplasia
in the uterine cervix with promising results.
Due to potential
diagnostic
pitfalls in
anal
cytology, p16 overexpression in these specimens was studied.
One slide of each
case
was destained.
RESULTS: Twenty-eight of the 43 cases demonstrated the presence
of squamous
cells immunoreactive for p16 in cytology specimens.
The p16-positive cells were identified in cases of low-grade
squamous
intraepithelial
lesion (LSIL) (n = 3 cases), high-grade
squamous
intraepithelial
lesion (HSIL) (n = 22 cases), and invasive
squamous
carcinoma (n =
1 case
), and in 2 cases with negative follow-up biopsies.
The sensitivity and specificity of p16 immunoreactivity in the detection of
anal intraepithelial neoplasia
or carcinoma were 72% and 71%, respectively.
CONCLUSIONS: The presence of p16 immunoreactivity is a good predictor
of dysplasia
in
anal
specimens.
However, the sensitivity and specificity of this marker are
not
high.
[MeSH-major]
Anus
Neoplasms / pathology. Biomarkers,
Tumor
/ analysis. Carcinoma in Situ / pathology. Neoplasms,
Squamous
Cell / pathology
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[Copyright]
(c) 2006 American Cancer Society.
(PMID = 16404747.001).
[ISSN]
0008-543X
[Journal-full-title]
Cancer
[ISO-abbreviation]
Cancer
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
70.
Alkaabi JM, Mushtaq A, Al-Maskari FN, Moussa NA, Gariballa S:
Hypokalemic periodic paralysis: a case series, review of the literature and update of management.
Eur J Emerg Med
; 2010 Feb;17(1):45-7
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[Title]
Hypokalemic periodic paralysis: a
case
series, review of the literature and update of management.
The objective of this
study
was to present a
case
series of patients with hypokalemic periodic paralysis.
We described all patients with
diagnosis
of hypokalemic periodic paralysis admitted to the Al
Ain
Hospital (UAE) during the year 2006.
Seventeen patients, all males and mostly Asians, were presented to the Al
Ain
Hospital over a 12-month period.
In conclusion, clinicians should have a high
index of
suspicion, especially among Asians presenting with flaccid paralysis and hypokalemia.
[MeSH-major]
Hypokalemic Periodic Paralysis /
diagnosis
[MeSH-minor]
Adult. Emigrants and Immigrants. Fluid Therapy. Humans. Hypokalemia /
diagnosis
. Hypokalemia / therapy. Male. Middle Aged. Potassium /
blood
. Potassium / therapeutic use. Seasons. Thyrotoxicosis / complications. United Arab Emirates. Young Adult
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(PMID = 20201128.001).
[ISSN]
1473-5695
[Journal-full-title]
European journal of emergency medicine : official journal of the European Society for Emergency Medicine
[ISO-abbreviation]
Eur J Emerg Med
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
RWP5GA015D / Potassium
[Number-of-references]
10
71.
Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA:
The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
Int J STD AIDS
; 2007 Feb;18(2):77-80
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[Title]
The prevalence, and predictive
value
, of abnormal
anal
cytology to
diagnose
anal
dysplasia in
a population of HIV-positive men who have sex with men.
Due to the increasing incidence of
anal
cancer in HIV-positive men who have sex with men, and the potential to detect and treat high-grade
anal
dysplasia
--the putative
anal
cancer precursor--we have introduced an
anal
cytology screening service.
Patients with abnormal
anal
cytology have follow-up high-resolution anoscopy (HRA) with biopsy of lesions clinically suspicious for high-grade
dysplasia
.
In total, 244 men were screened and 235 (96%) of the samples were adequate for cytological
interpretation
using the Bethesda 2001 system.
One hundred and sixty-four (67%) men had abnormal
anal
cytology, and 93 of them had follow-up HRA and
anal
biopsy.
The positive predictive
value
for any
anal
cytological abnormality to predict any degree of
anal
dysplasia
was 95.7+/-2.1%, and for any
anal
cytological abnormality to predict high-grade
anal
dysplasia
was 55.9+/-5.1%.
Abnormal
anal
cytology was highly predicative of
anal
dysplasia
on biopsy.
[MeSH-major]
Anal
Canal
/ pathology.
Anus
Neoplasms. Carcinoma,
Squamous
Cell. HIV Infections / complications. Homosexuality, Male
[MeSH-minor]
AIDS-Related Opportunistic Infections /
diagnosis
. AIDS-Related Opportunistic Infections / epidemiology. Adult. Aged. Biopsy. Cytological Techniques. Humans. Male. Middle Aged. Predictive
Value of
Tests. Prevalence
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(PMID = 17331275.001).
[ISSN]
0956-4624
[Journal-full-title]
International journal of STD & AIDS
[ISO-abbreviation]
Int J STD AIDS
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
72.
Printza N, Koukourgianni F, Saleh T, Goga C, Papachristou F:
Drug-induced interstitial nephritis in a child with idiopathic nephrotic syndrome.
Saudi J Kidney Dis Transpl
; 2009 Nov;20(6):1072-5
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Both the clinical picture of the
patient
as well as laboratory, imaging and histopathological findings may help in the
diagnosis
.
We present a
case of
drug-induced acute interstitial nephritis (
AIN
), complicated with ARF, in a 2(1/2) -year-old girl with active INS.
The child was referred to the Hippokration General Hospital, Thessaloniki, Greece hospital with steroid-resistant NS; renal biopsy was performed, which did
not
show any remarkable findings and cyclosporine was administered in addition to steroid therapy.
The first
day after biopsy, the child developed gross hematuria and abdominal pain and an antibiotic was added to her treatment.
Ultrasound
study
revealed enlarged kidneys with increased echogenity and loss of corticomedullary differentiation.
A second renal biopsy was performed, which confirmed the
diagnosis
of acute interstitial nephritis.
The child did
not
require
dialysis
therapy.
Our
case
re-emphasizes the need for investigation of factors precipitating ARF in children with idiopathic NS.
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(PMID = 19861874.001).
[ISSN]
1319-2442
[Journal-full-title]
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
[ISO-abbreviation]
Saudi J Kidney Dis Transpl
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Saudi Arabia
[Chemical-registry-number]
0 / Anti-Bacterial Agents; 0 / Immunosuppressive Agents; 0 / Steroids; 83HN0GTJ6D / Cyclosporine
73.
Saad AA, Awed NM, Abdel-Hafeez ZM, Kamal GM, Elsallaly HM, Alloub AI:
Prognostic value of immunohistochemical classification of diffuse large B-cell lymphoma into germinal center B-cell and non-germinal center B-cell subtypes.
Saudi Med J
; 2010 Feb;31(2):135-41
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[Title]
Prognostic
value of
immunohistochemical
classification of
diffuse large B-cell lymphoma into germinal center B-cell and non-germinal center B-cell subtypes.
OBJECTIVE: To
study the
expression of germinal center B-cell (GCB)/activated B-cell like-related proteins to get optimal stratification of diffuse large B-cell lymphoma (DLBCL) patients, and correlate this with the established clinical and laboratory parameters.
METHODS: This
study
was conducted retrospectively on 30 archival paraffin tissue blocks of DLBCL.
All patients were
diagnosed
between April 2004 and January 2007 at
Ain
Shams University Hospital and National Cancer
Institute
, Cairo, Egypt.
Each
case
included in this
study
was investigated by immunohistochemical reaction for multiple myeloma-1/interferon regulatory factor-4, B-cell/lymphoma 6, and cluster of differentiation10 monoclonal antibodies.
RESULTS: Patients were classified as GCB
group
(17 patients) and non-GCB
group
(13 patients).
We found a statistically significant association between non-GCB phenotype and performance status (PS) more than 1, high lactate dehydrogenase (LDH)
level
, advanced international prognostic
index
(IPI), and poor
patient
outcome.
Non-GCB phenotype, high LDH
level
, and PS more than 1 were all associated with increased mortality risk.
The median survival
time
was 46.9 months
in group
A compared to 19.6 months
in group
B (hazard ratio[HR]=3.30; 95% confidence
interval
[CI]=0.52-21.10).
CONCLUSION: The subclassification of DLBCL into GCB and non-GCB groups using immunohistochemistry may be useful for identifying those patients whose prognosis is so poor that more aggressive therapy can be given at
the time
of
diagnosis
.
[MeSH-major]
Lymphoma, Large B-Cell, Diffuse /
classification
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(PMID = 20174727.001).
[ISSN]
0379-5284
[Journal-full-title]
Saudi medical journal
[ISO-abbreviation]
Saudi Med J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Saudi Arabia
74.
Nadal SR, Calore EE, Nadal LR, Horta SH, Manzione CR:
[Anal cytology for screening of pre-neoplasic lesions].
Rev Assoc Med Bras (1992)
; 2007 Mar-Apr;53(2):147-51
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[Title]
[
Anal
cytology for screening of pre-neoplasic lesions].
[Transliterated title]
Citologia
anal
para rastreamento
de
lesões pré-neoplásicas.
BACKGROUND: High grade
intra
-
epithelial neoplasias
(HAIN) are probable precursors of
anal
carcinoma, with association to high-risk types of Human Papillomavirus (HPV).
This progression could be related to severity of the
dysplasia and
, albeit
not
yet confirmed, treatment of these lesions would prevent the evolution to cancer.
The aim of this
study
was to evaluate if
anal
cytology, with a cytobrush, could be useful to screen clinic and pre-clinic lesions provoked by HPV.
METHODS: Brushes were used to obtain smears from the
anal
canal of
102 HIV-positive patients with proctologic complaints.
HPV infection was denied by 33 patients, 14 had treated
anal
warts in the past, 28 had condylomas in the
anal
verge, seven had internal clinical lesions and 20 had both internal and external condylomas.
T CD4+ lymphocyte counts were also evaluated to check if the immunologic status caused more advanced
dysplasia
.
Low grade
AIN
(LAIN) occurred in 30 and HAIN in 13 patients.
One
patient
with HAIN, without a history of HPV infection in the past, presented an
anal
canal
ulcer which at biopsy was
diagnosed
as invasive
squamous
-cell carcinoma.
This fact demonstrated that isolated systemic immunity did
not
seem to interfere in the genesis of these lesions, suggesting that aspects of local immunity should be studied.
CONCLUSION: Results suggest that cytology could be used to
diagnose
anal
cancer precursors.
[MeSH-major]
Anus
Neoplasms / pathology. Carcinoma in Situ / pathology. HIV Infections / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / pathology. Precancerous Conditions / pathology
[MeSH-minor]
Adult. Female. Humans. Male. Mass Screening. Neoplasm
Staging
. Prospective Studies. Sensitivity and Specificity. Warts / pathology. Warts / virology
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(PMID = 17568919.001).
[ISSN]
0104-4230
[Journal-full-title]
Revista da Associação Médica Brasileira (1992)
[ISO-abbreviation]
Rev Assoc Med Bras (1992)
[Language]
por
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Brazil
75.
Walts AE, Thomas P, Bose S:
Anal cytology: is there a role for reflex HPV DNA testing?
Diagn Cytopathol
; 2005 Sep;33(3):152-6
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[Title]
Anal
cytology: is there a role for reflex HPV DNA testing?
There is an increased incidence of
anal
squamous
carcinoma and its precursor lesions (
anal intraepithelial neoplasia
[
AIN
]) among persons who engage in
anal
-receptive sex.
Analogous to cervical cancer screening,
anal
Papanicplaou (Pap) smears currently are used to screen these high-risk populations.
Human papilloma virus (HPV) has been implicated in
anal
carcinoma pathogenesis and this
study
was performed to assess the potential role of HPV DNA testing as an adjunct to
anal
cytology.
We correlated cytological
diagnoses and
HPV DNA (Digene Hybrid Capture [HC II] assay) in
anal
specimens collected in SurePath liquid medium from 118 patients; 54.8% of cases
diagnosed
as atypical
squamous
cells of undetermined significance (ASC-US) and 87.8%
diagnosed
as low-grade
squamous
intraepithelial
lesion (LSIL) or above tested positive for high- risk HPV DNA (B+).
Although a cytological
diagnosis
of ASC-US or above was a reliable indicator for
AIN
, cytology frequently did
not
accurately predict the grade of SIL in subsequent biopsy.
Our findings suggest that reflex HPV DNA testing would be helpful in triaging patients
diagnosed
with ASC-US.
However, patients
diagnosed
with LSIL or above should go directly to ansocopic biopsy.
[MeSH-major]
Anal
Canal
/ virology.
Anus
Neoplasms /
diagnosis
. Carcinoma in Situ /
diagnosis
. Carcinoma,
Squamous
Cell /
diagnosis
. Papillomavirus Infections /
diagnosis
.
Tumor
Virus Infections /
diagnosis
[MeSH-minor]
Adult. Biomarkers,
Tumor
/ analysis. DNA, Viral / analysis. Humans. Male. Mass Screening / methods. Middle Aged. Papillomaviridae / isolation & purification
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[Copyright]
Copyright (c) 2005 Wiley-Liss, Inc.
(PMID = 16078257.001).
[ISSN]
8755-1039
[Journal-full-title]
Diagnostic cytopathology
[ISO-abbreviation]
Diagn. Cytopathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / DNA, Viral
76.
El-Ashaal YI, Al-Olama AK, Abu-Zidan FM:
Trans-anal rectal injuries.
Singapore Med J
; 2008 Jan;49(1):54-6
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[Title]
Trans-
anal
rectal injuries.
INTRODUCTION: The
diagnosis
of trans-
anal
rectal injuries is usually delayed because of the
patient
's denial.
We aimed to
study the
causes, clinical presentation, management and clinical outcome of transanal rectal injuries.
METHODS: The records of 12 patients (nine males) with a median age of 36.5 (range 20-
64
) years, had trans-
anal
rectal injury and were treated between 1993 and 2006 at Al-
Ain
Hospital, were reviewed.
RESULTS: Injury was caused by a fall on a sharp object in five patients, by a rectal foreign
body in
two patients, by a compressed air hose in two patients, by sexual assault in two patients, and by rectal cleansing enema in one
patient
.
Seven patients presented two hours after the injury, four patients within 8-24 hours, and one sexually-assaulted
patient
presented after seven days.
The complication rate was significantly higher in the colostomy patients compared with
primary
repair (5/6 compared with 0/6, p-
value
is less than 0.02, Fisher's exact test).
CONCLUSION:
Diagnosis
of trans-
anal
rectal injuries is usually delayed because of late presentation.
Colostomy is
not
always mandatory.
[MeSH-major]
Anal
Canal
/ injuries. Rectum / injuries. Wounds, Nonpenetrating /
diagnosis
. Wounds, Penetrating /
diagnosis
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(PMID = 18204770.001).
[ISSN]
0037-5675
[Journal-full-title]
Singapore medical journal
[ISO-abbreviation]
Singapore Med J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Singapore
77.
Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O'Leary JJ:
p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.
J Clin Pathol
; 2005 May;58(5):525-34
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[Title]
p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive
neoplasia
and cervical cancer.
AIM: To analyse and compare expression patterns of three potential biomarkers-p16(INK4A), CDC6, and MCM5-and evaluate their use as predictive biomarkers
in squamous
and glandular cervical preinvasive
neoplasia
.
METHODS: Immunocytochemical analysis of p16(INK4A), MCM5, and CDC6 expression was performed on 20 normal, 38 cervical
intraepithelial neoplasia
1 (CIN1), 33 CIN2, 46 CIN3, 10
squamous
cell carcinoma, 19 cervical glandular
intraepithelial neoplasia
(cGIN), and 10 adenocarcinoma samples.
Staining
intensity
was assessed using a 0-3 scoring system. p16(INK4A), MCM5, and CDC6 expression was also examined in ThinPrep slides exhibiting mild, moderate, and severe
dyskaryosis
.
RESULTS: All three markers showed a linear correlation between expression and grade
of dysplasia
. p16(INK4A) and MCM5 protein expression was upregulated in all grades
of squamous
and glandular
dysplasia
.
CDC6 protein was preferentially expressed in high grade lesions and in invasive
squamous
cell carcinoma.
CONCLUSION: p16(INK4A) expression was closely associated with high risk HPV infection-all grades
of squamous
and glandular cervical lesions were immunohistochemically positive.
MCM5 staining
intensity
was independent of high risk HPV infection, highlighting its potential as a biomarker in both HPV dependent and independent cervical
dysplasia
.
CDC6 may be a biomarker of high grade and invasive lesions of the cervix, with limited use in low grade
dysplasia
. p16(INK4A) was the most reliable marker of cervical
dysplasia
.
Combinations of dysplastic biomarkers may be useful in difficult
diagnostic
cases.
[MeSH-major]
Biomarkers,
Tumor
/ analysis. Cell Cycle Proteins / analysis. Cervical
Intraepithelial Neoplasia
/ chemistry. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA-Binding Proteins / analysis.
Nuclear
Proteins / analysis. Schizosaccharomyces pombe Proteins / analysis. Uterine Cervical Neoplasms / chemistry
[MeSH-minor]
Adenocarcinoma / chemistry. Adenocarcinoma / complications. Adenocarcinoma / immunology. Antibodies, Monoclonal / immunology. Blotting, Western / methods. Carcinoma,
Squamous
Cell / chemistry. Carcinoma,
Squamous
Cell / complications. Carcinoma,
Squamous
Cell / immunology. Female. Humans. Immunohistochemistry / methods. Neoplasm Proteins / analysis. Neoplasm Proteins / immunology. Papillomaviridae / isolation & purification. Papillomavirus Infections / complications. Papillomavirus Infections /
diagnosis
. Risk Factors
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.
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Cited by Patents in
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Eur J Biochem. 2002 Feb;269(3):1040-6
[
11846807.001
]
(PMID = 15858126.001).
[ISSN]
0021-9746
[Journal-full-title]
Journal of clinical pathology
[ISO-abbreviation]
J. Clin. Pathol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; 0 / CDC6 protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Schizosaccharomyces pombe Proteins; 0 / mcm5 protein, S pombe
[Other-IDs]
NLM/ PMC1770660
78.
Settin A, Abu-Saif IS, El-Baz R, Dowaidar M, Kasim RA, Shabana S:
Diagnosis of Sex Chromosome Disorders and Prenatal Diagnosis of Down Syndrome using Interphase Fluorescent In-Situ Hyperidization Technique.
Int J Health Sci (Qassim)
; 2007 Jul;1(2):203-9
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[Title]
Diagnosis
of Sex Chromosome Disorders and Prenatal
Diagnosis
of Down Syndrome using Interphase Fluorescent In-Situ Hyperidization Technique.
OBJECTIVES: Evaluation of guidelines used for prenatal
diagnosis
of Down syndrome (DS) as well as sex chromosomal disorders including interphase Fluorescent In Situ Hyperidization (FISH) technique.
METHODS: Enrolled cases were among those presenting to Genetics and Neonatology Units, Mansoura
and Ain
-Shams University hospitals,(Egypt) during 2002 to 2004.
Groups 2 comprised suspected cases with sex chromosomal disorders including neonates with ambiguous genitalia (
64
cases) and adults with
primary
amenorrhea (69 cases) or infertility (38 cases).
They were subjected to a
diagnostic
workup including RESULTS: Among the pregnant women
group
, seven were found to be at a high risk of having DS fetuses including 3 cases with a history of affected off-springs, 2 cases with age above 35 years,
and 2
cases with high triple test.
Only one
case
had positive trisomy 21 on interphase FISH confirmed by karyogram on cultured amniotic cells.
Regarding the other
group
, 5 cases out of the 9 females were proved to be feminized males, one proved mosaic turner, one proved mixed gonadal dysgenesis
and 2
normal females.
On the other hand one out of three males were proved to be verilized female while the other one was a male with incomplete testicular feminization and the last one was a male with infertility
diagnosed
as Klinefelter syndrome at the age of 26 years.
It adds to
the diagnostic
utility of routine cytogenetics and its use on interphase nuclei overcomes the difficulty of conventional cytogenetics.
It could be used in the prenatal
diagnosis
of DS in addition to ultrasonography, and triple test.
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[Cites]
Chromosome Res. 2004;12(1):15-23
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]
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(PMID = 21475429.001).
[ISSN]
1658-3639
[Journal-full-title]
International journal of health sciences
[ISO-abbreviation]
Int J Health Sci (Qassim)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Saudi Arabia
[Other-IDs]
NLM/ PMC3068641
79.
Wang X, Zheng B, Zhang RR, Li S, Chen X, Mulvihill JJ, Lu X, Pang H, Liu H:
Automated analysis of fluorescent in situ hybridization (FISH) labeled genetic biomarkers in assisting cervical cancer diagnosis.
Technol Cancer Res Treat
; 2010 Jun;9(3):231-42
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[Title]
Automated analysis of fluorescent in situ hybridization (FISH) labeled genetic biomarkers in assisting cervical cancer
diagnosis
.
The numerical and/or structural
deviation of
some chromosomes (i.e., monosomy and _polysomy of chromosomes
3 and
X) are routinely used as positive genetic biomarkers to
diagnose
cervical cancer and predict
the disease
progression.
Among the available
diagnostic
methods to analyze the aneusomy of chromosomes
3 and
X, fluorescence in situ hybridization (FISH) technology has demonstrated significant advantages in assisting clinicians to more accurately detect
and diagnose
cervical carcinoma at an early
stage
, in particular for the women at a high risk for progression of low-grade and high-grade
squamous intra
-epithelium lesions (LSIL and HSIL).
In order to increase
the diagnostic
accuracy, consistency, and efficiency from that of manual FISH analysis, this
study
aims to develop and test an automated FISH analysis method that includes a two-
stage
scheme.
In the
first stage
, an interactive multiple-threshold algorithm is utilized to segment potential interphase nuclei candidates distributed in different
intensity
levels and a rule-based classifier is implemented to identify analyzable interphase cells.
In the second
stage
, FISH labeled biomarker spots of chromosomes
3 and
X are segmented by a top-hat transform.
Finally, the ratio of abnormal interphase cells with numerical changes of chromosomes
3 and
X is calculated to detect positive cases.
The experimental results of four test cases showed high agreement of FISH analysis results between the automated scheme and the cytogeneticist's analysis including 92.7% to 98.7% agreement in cell segmentation and 4.4% to 11.0% difference in cell
classification
.
This preliminary
study
demonstrates the feasibility of potentially applying the automatic FISH analysis method to expedite the screening and detecting cervical cancer at an early
stage
.
[MeSH-major]
Biomarkers,
Tumor
/ analysis. In Situ Hybridization, Fluorescence / methods. Uterine Cervical Neoplasms /
diagnosis
. Uterine Cervical Neoplasms / genetics
[MeSH-minor]
Automation. Cervical
Intraepithelial Neoplasia
/
diagnosis
. Cervical
Intraepithelial Neoplasia
/ genetics. Female. Humans.
Vaginal
Smears
Genetic Alliance.
consumer health - Cervical cancer
.
MedlinePlus Health Information.
consumer health - Cervical Cancer
.
COS Scholar Universe.
author profiles
.
International Agency for Research on Cancer - Screening Group.
diagnostics - A practical manual on visual screening for cervical neoplasia
.
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[ISSN]
1533-0338
[Journal-full-title]
Technology in cancer research & treatment
[ISO-abbreviation]
Technol. Cancer Res. Treat.
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / R01 CA136700; United States / NCI NIH HHS / CA / R01 CA136700-01; United States / NCI NIH HHS / CA / CA136700
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Other-IDs]
NLM/ NIHMS220245; NLM/ PMC2916642
80.
Chang VT, Cartwright PS, Bean SM, Palmer GM, Bentley RC, Ramanujam N:
Quantitative physiology of the precancerous cervix in vivo through optical spectroscopy.
Neoplasia
; 2009 Apr;11(4):325-32
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[Title]
Quantitative physiology of the precancerous cervix in vivo through
optical
spectroscopy.
The ability to quantify physiological and morphological changes in the cervix is
not
only useful in the
diagnosis
of cervical precancers but also important in aiding the design of cost-effective detection systems for use in developing countries that lack well-established screening
and diagnostic
programs.
We assessed the capability of a diffuse reflectance spectroscopy technique to identify contrasts
in optical
biomarkers that vary with different grades of cervical
intraepithelial neoplasia
(CIN) from normal cervical tissues.
The technology consists of an
optical
probe and an instrument (with broadband light source, dispersive
element
, and detector), and a Monte Carlo algorithm to extract
optical
biomarker contributions including total hemoglobin (Hb) concentration, Hb saturation, and reduced scattering coefficient from the measured spectra.
Among 38 patients and 89 sites examined, 46
squamous
normal sites, 18 CIN 1, and 15 CIN 2(+) sites were included in the analysis.
Hemoglobin saturation was
not
significantly altered in CIN 2(+) compared with normal and CIN 1.
MedlinePlus Health Information.
consumer health - Cervical Cancer
.
COS Scholar Universe.
author profiles
.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
International Agency for Research on Cancer - Screening Group.
diagnostics - A practical manual on visual screening for cervical neoplasia
.
The Lens.
Cited by Patents in
.
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(PMID = 19308287.001).
[ISSN]
1476-5586
[Journal-full-title]
Neoplasia (New York, N.Y.)
[ISO-abbreviation]
Neoplasia
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R21 CA108490; United States / NCI NIH HHS / CA / R21-CA108490-01
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Hemoglobins
[Other-IDs]
NLM/ PMC2657880
81.
Saadi H, Carruthers SG, Nagelkerke N, Al-Maskari F, Afandi B, Reed R, Lukic M, Nicholls MG, Kazam E, Algawi K, Al-Kaabi J, Leduc C, Sabri S, El-Sadig M, Elkhumaidi S, Agarwal M, Benedict S:
Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates.
Diabetes Res Clin Pract
; 2007 Dec;78(3):369-77
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[Title]
Prevalence of diabetes mellitus and its complications in a population-based sample in Al
Ain
, United Arab Emirates.
AIMS: To determine the prevalence of diabetes mellitus (DM) and its complications in the adult population of the United Arab Emirates (UAE) and assess the degree of metabolic control in subjects with
diagnosed
DM.
METHODS: A random sample of houses of Emirati citizens living in Al
Ain
, UAE was surveyed.
Fasting
blood
glucose was determined by glucose meter and an oral glucose tolerance test (OGTT) was conducted if
blood
sugar was <7 mmol/l.
Pre-diabetes status was based on fasting venous
blood
glucose concentration of 5.6-6.9 mmol/l or 2h post-OGTT venous
blood
glucose
level of
7.8-11.0 mmol/l.
RESULTS: There were 2455 adults (>18) living in the 452 surveyed houses of which 10.2% reported having the
diagnosis
of DM.
A total of 373 men and non-pregnant women underwent testing, and after adjustment for factors affecting participation probability the prevalence
of diagnosed
DM, undiagnosed DM and pre-diabetes was 10.5, 6.6 and 20.2%, respectively.
Age-standardized rates for DM (
diagnosed and
undiagnosed) and pre-diabetes among 30-
64
years old were 29.0 and 24.2%, respectively.
Logistic regression analysis showed that only age
and body
mass
index
(BMI) were significantly independently related to undiagnosed DM.
In patients with
diagnosed
DM, the prevalence rates for retinopathy, neuropathy, nephropathy, peripheral vascular
disease and
coronary heart
disease
were 54.2, 34.7, 40.8, 11.
1 and
10.5%, respectively.
The proportion of subjects with
diagnosed
DM who achieved internationally recognized targets for HbA1c (<7%), LDL-C (<2.6 mmol/l)
and blood
pressure (<130/80 mmHg) was 33.3, 30.8 and 42.1%, respectively.
CONCLUSION: This
study
confirms the previously reported high prevalence of DM in the UAE.
Diabetic complications were highly prevalent among subjects with
diagnosed and
undiagnosed DM.
Metabolic control was suboptimal in most subjects with
diagnosed
DM.
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(PMID = 17532085.001).
[ISSN]
1872-8227
[Journal-full-title]
Diabetes research and clinical practice
[ISO-abbreviation]
Diabetes Res. Clin. Pract.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Ireland
82.
Türkoglu-Raach G, Gröne HJ, Sitter T, Fischereder M:
[Another "suspect": homeopathic agent associated with acute interstitial nephritis].
Dtsch Med Wochenschr
; 2010 Jun;135(24):1224-7
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DIAGNOSIS
, TREATMENT AND COURSE: The chronic renal failure caused by an interstitial nephritis was treated with corticosteroids and hemodialysis treatment was started.
The trigger for
AIN
could
not
be found, there was no infectious or systemically
disease
nor a nephrotoxic
medication
identified.
For nearly six months
the patient
had taken a homeopathic agent which is a dilution of penicillium chrysogenum.
In case
of a determined allergy to penicillin, an extract of the fungus producing penicillin could possibly cause an interstitial nephritis.
The patient
was
dialysis
-independent with a GFR about 8 - 10 ml/
min
at
the time
of discharge.
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[Copyright]
Georg Thieme Verlag KG Stuttgart New York.
(PMID = 20533155.001).
[ISSN]
1439-4413
[Journal-full-title]
Deutsche medizinische Wochenschrift (1946)
[ISO-abbreviation]
Dtsch. Med. Wochenschr.
[Language]
ger
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Penicillins; 0 / Plant Extracts
83.
Voss JS, Kipp BR, Campion MB, Sokolova IA, Henry MR, Halling KC, Clayton AC:
Assessment of fluorescence in situ hybridization and hybrid capture 2 analyses of cervical cytology specimens diagnosed as low grade squamous intraepithelial lesion for the detection of high grade cervical intraepithelial neoplasia.
Anal Quant Cytol Histol
; 2010 Jun;32(3):121-30
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[Title]
Assessment of fluorescence in situ hybridization and hybrid capture 2 analyses of cervical cytology specimens
diagnosed
as low grade
squamous
intraepithelial
lesion for the detection of high grade cervical
intraepithelial neoplasia
.
OBJECTIVE: To assess Hybrid Capture 2 (HC2) and fluorescence in situ hybridization (FISH) for the detection of cervical
intraepithelial neoplasia
2 or worse (CIN 2+) in patients with a cytologic
diagnosis
of low grade
squamous
intraepithelial
lesion (LSIL).
STUDY
DESIGN: Residual samples from 115 LSIL-
diagnosed
cervical cytology specimens were evaluated by high-risk human papillomavirus (HR-HPV) HC2 testing and FISH using biotin-labeled probes to HR-HPV and chromosomal probes to 3q26 (TERC) and 8q24 (CMYC).
A cervical biopsy
diagnosis
of CIN 2+ was considered as evidence of high grade
disease
.
The sensitivities of HC2 and FISH for CIN 2+ were
not
significantly different (100% vs. 90%, p = 0.25), while the specificity of HC2 was significantly
lower
than that of FISH (28% vs. 48%, p=0.003).
FISH
diagnosed
fewer specimens as positive as compared to HC2 (62% vs. 79%).
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.
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(PMID = 20701064.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Neoplasm; 0 / DNA, Viral
84.
Vucic S, Yiannikas C:
Anterior interosseous nerve conduction study: normative data.
Muscle Nerve
; 2007 Jan;35(1):119-21
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[Title]
Anterior interosseous nerve conduction
study
: normative data.
Neurophysiological techniques assessing anterior interosseous nerve (
AIN
) function and employing surface electrode recordings from the flexor pollicis longus (FPL), have been limited by technical difficulties.
The aim of this
study
was to describe a surface electrode recording technique of investigating
the AIN
by recording compound muscle action potentials (CMAPs) from FPL.
[MeSH-minor]
Action Potentials / physiology. Adult. Aged. Electrodes / standards. Electromyography / instrumentation. Electromyography / methods. Female. Humans. Male. Median Neuropathy / complications. Median Neuropathy /
diagnosis
. Middle Aged. Paresis /
diagnosis
. Paresis / etiology. Predictive
Value of
Tests. Reference Values. Retrospective Studies
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(PMID = 16967471.001).
[ISSN]
0148-639X
[Journal-full-title]
Muscle & nerve
[ISO-abbreviation]
Muscle Nerve
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
85.
Voigt W, Kegel T, Weiss M, Mueller T, Simon H, Schmoll HJ:
Potential activity of paclitaxel, vinorelbine and gemcitabine in anaplastic thyroid carcinoma.
J Cancer Res Clin Oncol
; 2005 Sep;131(9):585-90
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Anaplastic thyroid carcinoma (ATC) has a rapidly fatal course in the mostly elderly patients with a median survival after
diagnosis
of 4-12 months.
Recently, based on preclinical data
Ain
et al. conducted a clinical phase II
study
with paclitaxel 96 h infusion in ATC achieving a promising response rate of 53%.
To further improve therapeutic options in ATC, we evaluated the activity of topotecan, oxaliplatin, vinorelbine, gemcitabine and paclitaxel in comparision to cisplatin and doxorubicin (
1 and
96 h drug exposure) alone or in combination in the ATC cell lines SW1736 and 8505C.
The activity of doxorubicin and cisplatin was moderate with RAA ranging from 1.4 to 2.
2 and
0.2 to 0.3, respectively.
Combined drug exposure of gemcitabine/paclitaxel and gemcitabine/vinorelbine was synergistic with a Loewe
index
> 0.
However, these results did
not
reach statistical significance with p > 0.05.
At clinically relevant drug concentrations paclitaxel, gemcitabine and vinorelbine but
not
oxaliplatin exerted a sustained growth inhibition after cessation of drug exposure for the complete assay
time of
15 days.
In conclusion, paclitaxel, gemcitabine and vinorelbine but
not
topotecan or oxaliplatin appeared to be active in anaplastic thyroid carcinoma based on RAA or growth delay at clinically relevant drug concentrations.
[MeSH-minor]
Cell Line,
Tumor
. Cisplatin / pharmacology. Doxorubicin / pharmacology. Drug Screening Assays, Antitumor. Drug Synergism. Humans. Organoplatinum Compounds / pharmacology. Topotecan / pharmacology
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.
Hazardous Substances Data Bank.
Topotecan
.
Hazardous Substances Data Bank.
CIS-DIAMINEDICHLOROPLATINUM
.
Hazardous Substances Data Bank.
DOXORUBICIN
.
Hazardous Substances Data Bank.
TAXOL
.
Hazardous Substances Data Bank.
VINORELBINE
.
Hazardous Substances Data Bank.
VINBLASTINE
.
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[Cites]
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2359136.001
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[
2145907.001
]
(PMID = 16021466.001).
[ISSN]
0171-5216
[Journal-full-title]
Journal of cancer research and clinical oncology
[ISO-abbreviation]
J. Cancer Res. Clin. Oncol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 5V9KLZ54CY / Vinblastine; 7M7YKX2N15 / Topotecan; 80168379AG / Doxorubicin; B76N6SBZ8R / gemcitabine; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; Q6C979R91Y / vinorelbine
86.
Dey P, Sharma N, Samanta S:
Fractal dimension of cervical intraepithelial lesions on cytology smear.
Anal Quant Cytol Histol
; 2010 Dec;32(6):320-2
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[Title]
Fractal dimension of cervical
intraepithelial
lesions on cytology smear.
OBJECTIVE: To explore the role of fractal dimension (FD) in distinguishing normal and different grades of cervical
intraepithelial
lesions.
STUDY
DESIGN: We selected 15 cases each of normal samples and low-grade
intraepithelial
lesions (LSIL) and 14 cases of high-grade
intraepithelial
lesions (HSIL).
The LSIL
diagnosis
was verified by two cytopathologists.
In each
case
at least 10 abnormal cells were selected in LSIL and HSIL cases and 10 normal cells in normal smears.
The FD was measured
in nucleus
of each cell by box counting FD method with the help of appropriate software.
RESULTS: The mean FD of the normal, LSIL, and HSIL
nucleus
was 1.2425 +/- 0.09188, 1.3504 +/- 0.6766,
and 1
.4379 +/- 0.08830, respectively.
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(PMID = 21456343.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
87.
Mansour HE, Metwaly KM, Hassan IA, Elshamy HA, Elbeblawy MM:
Antibodies to mutated citrullinated vimentin in rheumatoid arthritis: diagnostic value, association with radiological damage and axial skeleton affection.
Clin Med Insights Arthritis Musculoskelet Disord
; 2010 May 24;3:33-42
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[Title]
Antibodies to mutated citrullinated vimentin in rheumatoid arthritis:
diagnostic value
, association with radiological
damage and
axial skeleton affection.
BACKGROUND: Early definitive
diagnosis
and effective treatment are mandatory in rheumatoid arthritis (RA) as it can halt
the disease
progression and subsequent joints destruction.
OBJECTIVE: To investigate
the diagnostic
and prognostic
value of
anti-mutated citrullinated vimentin (anti-MCV) and its correlation with
disease
activity, peripheral and axial skeleton affection in RA patients.
PATIENTS AND METHODS: A total of 123 patients with different rheumatic
diseases
were enrolled in a prospective-two year
study
at
Ain
Shams University hospital:
64
patients with RA and 59 patients with other rheumatic
diseases
as controls.
RA patients were fulfilling the traditional and the new ACR/EULAR
diagnostic
criteria for RA.
At baseline, all RA patients were subjected to: Clinical assessment
of disease
activity by taking full histories, general and local examination, measurement of 28 joint count of tender and swollen joints with calculation
of disease
activity score (DAS-28) for each
patient
.
Complete
blood
count, erythrocytes sedimentation rate, C-reactive protein and rheumatoid factor titers were performed.
Anti-MCV IgG immunoglobulins' assay was performed at
the study
endpoint by ELISA.
RESULTS: Anti-MCV antibodies were found to be of high sensitivity (79.6%) and specificity (96.6%)
in diagnosing
RA.
The area under the curve was 0.893 at 95% confidence
interval
(CI), confers an odds ratio of 23.5.
Anti-MCV positive RA patients had significantly higher DAS-28 and SEN-scores than anti-MCV negative patients; who were found to have more benign
disease
with
lower
incidence of erosions (P < 0.05).
MRI scans revealed that; 17/22 (77%) had cervical joints involvement while, 8 (36%) had lumbo-sacral joint lesions (P < 0.05), both were correlated significantly with aggressive peripheral joint
disease
.
CONCLUSION: Anti-MCV antibodies are promising
diagnostic and
prognostic marker in RA, with high sensitivity and specificity.
They may identify a subset of RA patients with aggressive early erosive
disease
.
The axial skeleton-especially the cervical spine-could be affected in RA and this was correlated with aggressive peripheral joints'
disease
.
MRI scanning is a sensitive method for detecting axial skeleton involvement in RA, in attempt for better
disease
control and outcomes.
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(PMID = 21124694.001).
[ISSN]
1179-5441
[Journal-full-title]
Clinical medicine insights. Arthritis and musculoskeletal disorders
[ISO-abbreviation]
Clin Med Insights Arthritis Musculoskelet Disord
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2989636
[Keywords]
NOTNLM ; RA / anti-MCV / anti-mutated citrullinated vimentin / rheumatoid arthritis
88.
Lane SW, Hassell P, Kennedy GA, Fung YL, Williams BA:
Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia.
Int J Lab Hematol
; 2009 Oct;31(5):567-71
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It may be used to differentiate childhood autoimmune neutropenia (
AIN
) from other causes of childhood neutropenia, even when circulating neutrophil counts are low.
We sought to characterize
the diagnostic
utility of the BMIFT in childhood
AIN
.
Patients were classified as
AIN
or nonautoimmune causes.
There were 45 patients
diagnosed
with
AIN
, 28 with nonimmune neutropenia and three failed tests.
The median age of children with
AIN
was 1.2 years (range 0.3-15.3), compared with 3.6 years (range 0.1-15.7) in the nonautoimmune
group
.
The median neutrophil count
in AIN
was 0.3 x 10(9)/l (0.9 x 10(9)/
l in
nonautoimmune).
BMIFT was positive in 24 of 45 patients with
AIN and
0 of 28 with nonautoimmune neutropenia (sensitivity 53%, specificity 100%, positive predictive
value
(PPV) 100%, negative predictive
value
57%).
Ten patients had other autoimmune diatheses at
diagnosis
.
The BMIFT is a simple, highly specific test with excellent PPV and thus is a clinically useful test to confirm
AIN in
children.
[MeSH-major]
Autoantibodies / immunology. Bone Marrow / immunology. Fluorescent Antibody Technique. Neutropenia /
diagnosis
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(PMID = 18637806.001).
[ISSN]
1751-553X
[Journal-full-title]
International journal of laboratory hematology
[ISO-abbreviation]
Int J Lab Hematol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Autoantibodies
89.
Owens SR, Greenson JK:
Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas.
Am J Surg Pathol
; 2007 Feb;31(2):285-90
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[Title]
Immunohistochemical staining for p63 is useful in the
diagnosis
of
anal
squamous
cell carcinomas.
Anal
canal
carcinomas account for between 1%
and 2
% of all gastrointestinal carcinomas in the United States.
By far, the most common carcinoma in this site is
squamous
cell carcinoma, but
the differential
diagnosis
typically includes poorly differentiated adenocarcinoma and well-differentiated neuroendocrine carcinoma or carcinoid
tumor
.
Because
the first diagnostic
specimen received in the pathology laboratory is usually a small, sometimes suboptimal biopsy, the distinction of these types of carcinoma can be difficult.
However, accurate
diagnosis
is imperative, because the treatment differs between
squamous
carcinoma (chemoradiation) and the other types of carcinoma (surgical therapy).
The p63 protein has been previously shown to be involved
in epithelial
proliferation and differentiation, and is known to be related to
squamous
carcinomas in many sites.
Therefore, we undertook to ascertain its usefulness in the
diagnosis
of squamous
carcinomas in the
anal
canal
.
We retrieved 24
anal
squamous
carcinomas, 68 colorectal adenocarcinomas (including a tissue microarray), and 32 colorectal neuroendocrine carcinomas from the archives at the University of Michigan, and immunostained them for the p63
antigen
.
As a result, this immunohistochemical stain had a specificity of 98% and a positive predictive
value of
92% for
squamous
cell carcinoma once invasive carcinoma had been established.
It also stained the dysplastic
epithelial
cells in adjacent areas of
anal intraepithelial neoplasia
.
We report that the p63 immunostain is a highly specific and useful tool in the
diagnosis
of carcinomas of the
anal
canal
.
[MeSH-major]
Anal
Canal
/ metabolism.
Anus
Neoplasms / metabolism. Biomarkers,
Tumor
/ metabolism. Carcinoma,
Squamous
Cell / metabolism. DNA-Binding Proteins / metabolism. Immunoenzyme Techniques / methods. Trans-Activators / metabolism.
Tumor
Suppressor Proteins / metabolism
[MeSH-minor]
Carcinoid
Tumor
/
diagnosis
. Carcinoid
Tumor
/ metabolism. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma, Neuroendocrine /
diagnosis
. Carcinoma, Neuroendocrine / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology.
Diagnosis
,
Differential
. Humans. Predictive
Value of
Tests. Tissue Array Analysis. Transcription Factors
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(PMID = 17255774.001).
[ISSN]
0147-5185
[Journal-full-title]
The American journal of surgical pathology
[ISO-abbreviation]
Am. J. Surg. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
90.
Sarzo G, Del Mistro A, Finco C, Frayle-Salamanca H, Marino F, Franzetti M, Ferrara R, Mistrangelo M, Savastano S, Vecchiato M, Merigliano S:
Extensive anal condylomatosis: prognosis in relation to viral and host factors.
Colorectal Dis
; 2010 Jul;12(7 Online):e128-34
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[Title]
Extensive
anal
condylomatosis: prognosis in relation to viral and host factors.
OBJECTIVE: To evaluate the clinical course of extensive
anal
condylomatosis in relation to treatment modalities,
patient
comorbidity and immune function, and associated papillomavirus (HPV) sequences.
Histology, immunohistochemistry
and molecular
analyses for HPV search and typing were performed on formalin-fixed paraffin-embedded samples.
RESULTS: Sixteen patients [14 males, median age 41.8 years (range 19-66)] affected by extensive
anal
condylomatosis [10 Buschke-Lowenstein Tumors (BLT) and 6 condylomatosis] treated in three different Italian institutions were included.
There was associated preoperative
anal intraepithelial neoplasia
grade 3 (AIN3) in one and invasive carcinoma in three patients.
Viral variant L83V was present
in 3
/4 HPV 16 positive recurrent cases.
Typing of HPV sequences in the management of patients affected by extensive
anal
condylomatosis may be useful.
[MeSH-minor]
Adult. Aged.
Diagnosis
,
Differential
. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Young Adult
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[ErratumIn]
Colorectal Dis. 2010 Oct;12(10):1072. Mistro, A [corrected to Del Mistro, A]
(PMID = 19508521.001).
[ISSN]
1463-1318
[Journal-full-title]
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
[ISO-abbreviation]
Colorectal Dis
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / DNA, Viral
91.
Simpson IJ, Marshall MR, Pilmore H, Manley P, Williams L, Thein H, Voss D:
Proton pump inhibitors and acute interstitial nephritis: report and analysis of 15 cases.
Nephrology (Carlton)
; 2006 Oct;11(5):381-5
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The aim of the present
study
was to report and analyse the clinical features of 15 patients with acute interstitial nephritis (
AIN
) and acute renal failure from PPI that were referred to renal services in Auckland over a period
of 3
years.
The
diagnosis
of AIN
was made by renal biopsy in 12 cases.
In all patients,
the time
-course of drug exposure and improvement of renal function on withdrawal suggested PPI were causal.
RESULTS: The median
patient
age was 78 years.
The mean baseline serum creatinine
level
was 83 micromol/L, peak
level
392 micromol/L, and recovery
level
139 micromol/L.
The erythrocyte sedimentation rate (ESR) and C-reactive protein were elevated at
the time
of
diagnosis
in the 11 and 12 patients, respectively, where this information was collected (ESR mean 85 mm/h, and C-reactive protein mean 81 mg/L).
AIN
occurred at 8 per 100 000
patient
years (95% confidence
level 2
.6-18.7 per 100 000
patient
years).
CONCLUSION: PPI are now the most commonly identified cause
of AIN
in the Auckland area.
Early
diagnosis
may be facilitated by clinician awareness of the insidious onset of renal failure, and an elevated erythrocyte sedimentation rate and C-reactive protein.
[MeSH-minor]
2-Pyridinylmethylsulfinylbenzimidazoles / adverse effects. Aged. Aged, 80 and over. Anti-Ulcer Agents / adverse effects. Biopsy.
Blood
Sedimentation. C-Reactive Protein / metabolism. Female. Humans. Male. Middle Aged. Risk Factors
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[CommentIn]
Nephrology (Carlton). 2006 Oct;11(5):379-80
[
17014548.001
]
(PMID = 17014549.001).
[ISSN]
1320-5358
[Journal-full-title]
Nephrology (Carlton, Vic.)
[ISO-abbreviation]
Nephrology (Carlton)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Australia
[Chemical-registry-number]
0 / 2-Pyridinylmethylsulfinylbenzimidazoles; 0 / Anti-Ulcer Agents; 0 / Enzyme Inhibitors; 0 / Proton Pump Inhibitors; 9007-41-4 / C-Reactive Protein; D8TST4O562 / pantoprazole; KG60484QX9 / Omeprazole
92.
Kamel H, Abdelazim I, Habib SM, El Shourbagy MAA, Ahmed NS:
Immunoexpression of matrix metalloproteinase-2 (MMP-2) in malignant ovarian epithelial tumours.
J Obstet Gynaecol Can
; 2010 Jun;32(6):580-586
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[Title]
Immunoexpression of matrix metalloproteinase-2 (MMP-2) in malignant ovarian
epithelial
tumours.
OBJECTIVES: This
study
was designed to evaluate the expression of matrix metalloproteinase-2 (MMP-2) in malignant ovarian
epithelial
tumours and to detect the relation between the degree of MMP-2 expression and the histological grade and surgical
stage of
the studied cases.
METHODS: This
study
was conducted
in Ain
Shams University Maternity Hospital in Cairo, Egypt, between March 2004 and December 2005.
Thirty patients with malignant ovarian
epithelial
tumours
diagnosed
after histopathological examination of the specimens were included in this
study
.
The staining
intensity of
MMP-2 was correlated with the clinical and pathological parameters of the studied cases, including
patient
's age, surgical
stage
, histological grade, omental metastasis, and lymph node metastasis.
The results were compared with the clinical and pathological parameters, including
patient
's age, tumour
stage
, and histological grade.
The MMP-2 expression was found to be significantly correlated with the histological grade (r = 0.52, P < 0.05) and with the surgical
stage
(r = 0.72, P < 0.001) of the studied tumours, but
not
with the age of the patients.
In this
study
, there was a direct correlation between the degree of expression of MMP-
2 and
histologically undifferentiated or advanced
stages of
ovarian
epithelial
tumours.
[MeSH-major]
Matrix Metalloproteinase 2 / metabolism. Neoplasms, Glandular
and Epithelial
/ enzymology. Ovarian Neoplasms / enzymology
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consumer health - Ovarian Cancer
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(PMID = 20569539.001).
[ISSN]
1701-2163
[Journal-full-title]
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
[ISO-abbreviation]
J Obstet Gynaecol Can
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
EC 3.4.24.24 / Matrix Metalloproteinase 2
93.
Greene MD:
Diagnosis and management of HPV-related anal dysplasia.
Nurse Pract
; 2009 May;34(5):45-51
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[Title]
Diagnosis
and management of HPV-related
anal
dysplasia
.
[MeSH-major]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / therapy. Nurse Practitioners / organization & administration. Papillomavirus Infections /
diagnosis
. Papillomavirus Infections / therapy.
Primary
Health Care / methods
[MeSH-minor]
AIDS-Related Opportunistic Infections / complications. Algorithms. Biopsy. Cytodiagnosis. Decision Trees. Humans. Mass Screening. Neoplasm
Staging
. Nursing Assessment.
Patient
Education as Topic.
Primary
Prevention. Proctoscopy. Risk Factors. United States / epidemiology
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(PMID = 19390399.001).
[ISSN]
1538-8662
[Journal-full-title]
The Nurse practitioner
[ISO-abbreviation]
Nurse Pract
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
65
94.
Samaratunga H, Gardiner RA, Yaxley J, Brown I:
Atypical prostatic glandular proliferations on needle biopsy: Diagnostic implications, use of immunohistochemistry, and clinical significance.
Anal Quant Cytol Histol
; 2006 Apr;28(2):104-10
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[Title]
Atypical prostatic glandular proliferations on needle biopsy:
Diagnostic
implications, use of immunohistochemistry, and clinical significance.
In recent times, PSA screening and a substantial increase in prostate needle biopsies have
not
only resulted in detection of minute foci of cancer but have also very likely resulted in increased detection of atypical glandular proliferations.
Not
uncommonly, there are only a limited
number of
atypical glands in these biopsies, and these require careful evaluation to enable an accurate
diagnosis
.
We describe
diagnostic
implications, use of immunohistochemistry, and clinical significance of these lesions.
Foci of atypical glands, also labeled atypical small acinar proliferation of uncertain significance, have features suspicious for but
not diagnostic
of cancer.
Atypical foci include a broad
group of
lesions of differing clinical significance.
Definite
diagnosis
requires accurate histopathologic assessment and judicious use of immunohistochemistry.
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(PMID = 16637513.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
35
95.
Hefny AF, Eid HO, Al-Hussona M, Idris KM, Abu-Zidan FM:
Necrotizing fasciitis: a challenging diagnosis.
Eur J Emerg Med
; 2007 Feb;14(1):50-2
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[Title]
Necrotizing fasciitis: a challenging
diagnosis
.
The objective of the
study
was to evaluate our recent experience in
diagnosis
and management of necrotizing fasciitis.
Records of patients who were
diagnosed
as having necrotizing fasciitis at Al-
Ain
Hospital in the period between March 2003 and August 2005 were studied retrospectively with regard to clinical features, risk factors,
diagnosis
, causative organisms, treatment, and outcome.
The main risk factor was diabetes mellitus in seven patients (
64
%).
The provisional clinical
diagnosis
was incorrect in seven patients (
64
%).
Pure beta-hemolytic streptococcus
group
A or B was the causative organism in five patients (46%).
High clinical suspicion is essential for the
diagnosis
of necrotizing fasciitis.
Accurate early
diagnosis
, aggressive resuscitation, using proper antibiotics, and extensive surgical debridement are essential for a favorable outcome.
[MeSH-major]
Fasciitis, Necrotizing /
diagnosis
. Streptococcal Infections / complications
[MeSH-minor]
Adolescent. Adult. Aged. Anti-Bacterial Agents / therapeutic use. Child. Debridement. Diabetes Complications /
diagnosis
. Diabetes Complications / therapy.
Diagnostic
Errors. Female. Humans. Length of Stay. Male. Middle Aged. Retrospective Studies. Risk Factors. Social Class. Streptococcus / isolation & purification
Genetic Alliance.
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(PMID = 17198329.001).
[ISSN]
0969-9546
[Journal-full-title]
European journal of emergency medicine : official journal of the European Society for Emergency Medicine
[ISO-abbreviation]
Eur J Emerg Med
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Anti-Bacterial Agents
96.
Mathews WC, Cachay ER, Caperna J, Sitapati A, Cosman B, Abramson I:
Estimating the accuracy of anal cytology in the presence of an imperfect reference standard.
PLoS One
; 2010 Aug 19;5(8):e12284
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[Title]
Estimating the accuracy of
anal
cytology in the presence of an imperfect reference standard.
BACKGROUND:
The study
aim is to estimate sensitivity and specificity of
anal
cytology for histologic HSIL in analyses adjusted for the imperfect biopsy reference standard.
METHODS AND PRINCIPAL FINDINGS: Retrospective cohort
study of
an
anal
dysplasia
screening program for HIV infected adults.
The study
cohort included 261 patients with 3 available measures:.
The prevalence of biopsy HSIL varied according to the concurrent HRA cytology result:
64
.5% for HSIL or ASC-H, 12.6% for LSIL, 10.9% for ASCUS, and 6.3% for no abnormality.
CONCLUSIONS: Analysis of a single dataset yields widely different estimates of
anal
cytology operating characteristics that depend on difficult to verify assumptions regarding the accuracy of the imperfect reference standard.
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[Cites]
Br J Cancer. 2002 Jul 1;87(1):61-4
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12085257.001
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[ISSN]
1932-6203
[Journal-full-title]
PloS one
[ISO-abbreviation]
PLoS ONE
[Language]
ENG
[Grant]
United States / NIAID NIH HHS / AI / P30 AI036214; United States / NIAID NIH HHS / AI / R24 AI067039; United States / NIAID NIH HHS / AI / AI 36214; United States / NIAID NIH HHS / AI / AI067039
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2924391
97.
Ogino Y, Osada K, Nakamura S, Ohta Y, Kanda T, Sugano M:
Absorption of dietary cholesterol oxidation products and their downstream metabolic effects are reduced by dietary apple polyphenols.
Lipids
; 2007 Mar;42(2):151-61
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[Title]
Absorption
of dietary
cholesterol oxidation
products and
their downstream metabolic effects are reduced by
dietary
apple polyphenols.
Exogenous and endogenous cholesterol oxidation
products
(COPs) perturb various metabolic processes, and thereby they may induce various homeostasis-related disorders.
Here, we observed that procyanidin-rich
dietary
apple polyphenol (APP) from unripe apples alleviates the perturbation of lipid metabolism by decreasing the exogenous COP levels in rats.
Dietary
COPs may be the greatest source of COPs found in the human
body
.
Rats (4 weeks of age) were fed
AIN
-purified diets containing 0.3% COPs supplemented with 0.5 or 2.5% APP for 3 weeks.
Dietary
APP alleviated the growth inhibition action of the exogenous COPs.
However, serum total cholesterol, high-
density
lipoprotein cholesterol, and triglyceride levels increased following the intake
of dietary
APP.
Further,
dietary
APP inhibited the increase in lipid peroxide levels in the liver and serum by COPs.
The activity of hepatic Delta6 desaturase was lowered by
dietary
APP in a
dose
-dependent manner, although exogenous COPs generally increased the activity of this enzyme.
In keeping with this observation, Delta6
desaturation indices
in the phospholipids and cholesteryl esters of the liver and serum lipids were
lower in
the APP-fed groups than those in the control
group
.
Dietary
APP also promoted the excretion of exogenous COPs, cholesterol, and acidic steroids in feces.
[MeSH-major]
Cholesterol,
Dietary
/ pharmacokinetics. Flavonoids / pharmacology. Malus / chemistry. Phenols / pharmacology
[MeSH-minor]
Animals.
Body
Weight / drug effects. Chromatography, Gas. Enzyme Activation / drug effects. Erythrocytes / metabolism. Feces / chemistry. Intestinal Absorption / drug effects. Lipid Metabolism / drug effects. Lipid Peroxides / metabolism. Lipids /
blood
. Mass Spectrometry.
Molecular Structure
. Oxidation-Reduction / drug effects. Polyphenols. Prostaglandins / metabolism. Rats. Rats, Sprague-Dawley. Steroids / metabolism. Superoxide Dismutase / metabolism
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[ISSN]
0024-4201
[Journal-full-title]
Lipids
[ISO-abbreviation]
Lipids
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Cholesterol, Dietary; 0 / Flavonoids; 0 / Lipid Peroxides; 0 / Lipids; 0 / Phenols; 0 / Polyphenols; 0 / Prostaglandins; 0 / Steroids; EC 1.15.1.1 / Superoxide Dismutase
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