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1. Bean SM, Chhieng DC: Anal-rectal cytology: a review. Diagn Cytopathol; 2010 Jul;38(7):538-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal-rectal cytology: a review.
  • The incidence of invasive anal squamous cell carcinoma, a human papilloma virus (HPV) related cancer, is on the rise, especially in HIV positive men who have sex with men (MSM).
  • Like cervical cancer, anal cancer is associated with precursor lesions detectable on exfoliative cytology as squamous intraepithelial lesions and on biopsy as intraepithelial neoplasia.
  • Anal-rectal cytology screening programs, similar to cervical cytology screening programs, have been developed in an effort to detect and to eradicate precursor lesions prior to progression to invasive squamous cell carcinoma.
  • Either conventional or liquid-based anal-rectal cytology specimens are acceptable, but liquid-based specimens are preferred.
  • A minimum of 2,000-3,000 nucleate squamous cells should comprise adequate specimens.
  • Sensitivity and specificity of a single anal-rectal cytology specimen is comparable with that of a single cervical cytology test, but cytological interpretations do not always correlate with lesion severity.
  • Patients with atypical squamous cells of undetermined significance (ASC-US) or worse should be referred for anoscopy.
  • [MeSH-major] Anal Canal / pathology. Rectum / pathology
  • [MeSH-minor] Anus Neoplasms / diagnosis. Anus Neoplasms / epidemiology. Anus Neoplasms / pathology. Early Detection of Cancer. Humans. Papillomaviridae / physiology. Specimen Handling

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19941374.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 78
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2. Sarwar Gilani G, Nimal Ratnayake WM, Peace RW, Mueller R: Effects of supplemental cystine or methionine on growth and lifespan of stroke-prone spontaneously hypertensive rats. Br J Nutr; 2006 Mar;95(3):443-7
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  • The data would suggest that a control diet based on cystine-supplemented casein (as recommended for normal healthy rats by the American Institute of Nutrition), may not meet the sulphur amino acid requirements for SHRSP rats, and that the methionine-supplemented casein would be an appropriate control diet for this animal model.

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  • (PMID = 16512928.001).
  • [ISSN] 0007-1145
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Caseins; 0 / Dietary Proteins; 0 / Soybean Proteins; 48TCX9A1VT / Cystine; AE28F7PNPL / Methionine
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3. Simões FC, Marques RG, Diestel CF, Caetano CE, Dinis AP, Horst NL, Nogueira Neto JF, Portela MC: Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant. Acta Cir Bras; 2007 Mar-Apr;22 Suppl 1:46-51
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  • Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993).

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  • (PMID = 17505655.001).
  • [ISSN] 0102-8650
  • [Journal-full-title] Acta cirurgica brasileira
  • [ISO-abbreviation] Acta Cir Bras
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Lipids; 0 / Lipoproteins; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
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4. Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, Su D, Sano M, Lytwyn A, Chapman W, Mahony J: Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology. Cancer Epidemiol Biomarkers Prev; 2009 Jul;18(7):1986-92
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  • [Title] Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology.
  • BACKGROUND: HIV-positive men with a history of anal-receptive intercourse are at risk for anal cancer.
  • We determined whether human papilloma virus (HPV) biomarkers were correlated with anal pathology in these men.
  • The number of HPV genotypes per anal swab was higher for anal intraepithelial neoplasia (AIN) 2/3 than for normal or AIN 1 histology [median, 5 types (interquartile range) (IQR), 3-7 versus 3.5 (IQR), 2-6; P = 0.0005].
  • HPV 16 viral load was also associated with AIN 2/3 histology.
  • CONCLUSIONS: The presence of high-grade anal pathology (AIN 2/3) in HIV-positive men was associated with multiple HPV genotypes, HPV genotypes 16 and 31, and HPV 16 viral load.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Neoplasms / epidemiology. Carcinoma in Situ / epidemiology. Genes, p16. HIV Seropositivity / virology. Oncogene Proteins, Viral / genetics. Repressor Proteins / genetics

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  • (PMID = 19567510.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / E6 protein, Human papillomavirus type 16; 0 / Oncogene Proteins, Viral; 0 / Repressor Proteins
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5. Anderson JS, Hoy J, Hillman R, Barnden M, Eu B, McKenzie A, Gittleson C: A randomized, placebo-controlled, dose-escalation study to determine the safety, tolerability, and immunogenicity of an HPV-16 therapeutic vaccine in HIV-positive participants with oncogenic HPV infection of the anus. J Acquir Immune Defic Syndr; 2009 Nov 1;52(3):371-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A randomized, placebo-controlled, dose-escalation study to determine the safety, tolerability, and immunogenicity of an HPV-16 therapeutic vaccine in HIV-positive participants with oncogenic HPV infection of the anus.
  • OBJECTIVE: Study aimed to assess safety, tolerability, and immunogenicity of novel therapeutic HPV-16 E6E7 ISCOMATRIX vaccine for treatment of human papilloma virus (HPV)-related anal intraepithelial neoplasia in HIV-infected men who have sex with men with moderate immunosuppression.
  • RESULTS: Thirty-five men who have sex with men enrolled; median age 47 years; current CD4 count 627 cells per milliliter; nadir CD4 count 154 cells per milliliter; 94% current antiretrovirals; 100% high-risk HPV types; 69% abnormal anal cytology; and 34% anal intraepithelial neoplasia 1-3 on high-resolution anoscopy.
  • [MeSH-major] Anus Neoplasms / therapy. HIV Infections / complications. Human papillomavirus 16. Papillomavirus Infections / therapy. Papillomavirus Vaccines / therapeutic use

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  • (PMID = 19661810.001).
  • [ISSN] 1944-7884
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antibodies, Viral; 0 / Drug Combinations; 0 / ISCOMATRIX; 0 / Papillomavirus Vaccines; 0 / Phospholipids; 0 / Saponins; 97C5T2UQ7J / Cholesterol
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6. Gasztonyi B, Pár G, Pár A, Hunyady B: [Safety of pegylated interferon in patients with hepatitis C virus induced cirrhosis]. Orv Hetil; 2005 Nov 27;146(48):2431-4
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  • OBJECTIVES: The authors described their experience with the therapy with pegylated interferon and its safety in patients with hepatitis C virus (HCV) induced liver cirrhosis treated at First Department of Medicine, Medical School, University of Pécs and at Tawam Hospital, Al Ain, United Arab Emirates.

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  • (PMID = 16408382.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2a; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 76543-88-9 / interferon alfa-2a; 99210-65-8 / interferon alfa-2b
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7. Hirayama K, Uetsuka K, Kuwabara Y, Tamura M, Itoh K: Vitamin K deficiency of germfree mice caused by feeding standard purified diet sterilized by gamma-irradiation. Exp Anim; 2007 Jul;56(4):273-8
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  • Germfree mice died when they were fed a purified diet of AIN-76 formula sterilized by gamma-irradiation.
  • Germfree mice were fed purified diets of AIN-76 or AIN-93M formula, which were pelleted and sterilized by gamma-irradiation at a dose of 50 kGy.
  • One half of the mice fed the AIN-76 diet died within two weeks and the surviving animals were also in poor health, while 91% of mice fed the AIN-93M diet survived.
  • Histologically, degeneration with inflammatory cell infiltration was observed as well as hemorrhage and fibrosis in the heart muscles of mice fed the AIN-76 diet.
  • Prothrombin time (PT) and activated partial thromboplastin time (APTT) were extremely prolonged when mice were fed the AIN-76 diet.
  • The animals totally recovered when they were intragastrically administered 1 microg/day of vitamin K(3) from the third day of feeding of the AIN-76 diet, except for PT and APTT which were still slightly longer than in mice fed the AIN-93M diet.
  • The concentration of vitamin K(3) supplied in the AIN-76 diet decreased to an undetectable level after gamma-irradiation, while the AIN-93M diet contained 240 microg/kg of vitamin K(1).
  • These results indicate that the deaths of the germfree mice fed the gamma-irradiated AIN-76 diet were caused by vitamin K deficiency.

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  • (PMID = 17660681.001).
  • [ISSN] 1341-1357
  • [Journal-full-title] Experimental animals
  • [ISO-abbreviation] Exp. Anim.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 723JX6CXY5 / Vitamin K 3; 84-80-0 / Vitamin K 1
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8. Cranston RD, Hirschowitz SL, Cortina G, Moe AA: A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men. Int J STD AIDS; 2008 Feb;19(2):118-20
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  • [Title] A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men.
  • HIV-positive men who have sex with men (MSM) are at high risk of developing human papillomavirus-associated anal squamous cell cancer.
  • Similar to the management of cervical dysplasia, clinicians are treating high-grade anal dysplasia to prevent progression to cancer.
  • Infrared coagulation (IRC) is an outpatient treatment for high-grade anal dysplasia.
  • This retrospective clinical study reports on 68 HIV-positive MSM with 78 biopsy proven high-grade anal lesions.
  • Of the 74 evaluable lesions; 39 had anal intraepithelial neoplasia (AIN) 1, 20 had AIN 2, seven had AIN 3, and eight had normal epithelium.
  • The IRC showed 64% efficacy per treated lesion and shows promise as a treatment modality for high-grade anal dysplasia in this population.
  • [MeSH-major] Anus Diseases / pathology. Anus Diseases / radiotherapy. Anus Neoplasms / prevention & control. HIV Infections / complications. HIV Seropositivity / complications. Homosexuality, Male. Infrared Rays / therapeutic use


9. Lin CY, Tsai ZY, Cheng IC, Lin SH: Effects of fermented soy milk on the liver lipids under oxidative stress. World J Gastroenterol; 2005 Dec 14;11(46):7355-8
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  • METHODS: Forty-five healthy male Sprague-Dawley rats were randomly assigned to five groups according to five different diets: control (AIN-76), AIN-76+high-dose fermented soy milk powder, AIN-76+low-dose fermented soy milk powder, AIN-76+high-dose milk yogurt powder and AIN-76+low-dose milk yogurt powder.

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  • (PMID = 16437642.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Powders; 0 / Thiobarbituric Acid Reactive Substances; CL2T97X0V0 / Carbon Tetrachloride; EC 3.1.3.1 / Alkaline Phosphatase
  • [Other-IDs] NLM/ PMC4725133
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10. Grafe MW, Kim PD, Rosenwasser MP, Strauch RJ: Wrist denervation and the anterior interosseous nerve: anatomic considerations. J Hand Surg Am; 2005 Nov;30(6):1221-5
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  • PURPOSE: Wrist denervation via resection of the distal anterior interosseous nerve (AIN) and the posterior interosseous nerve (PIN) is an effective treatment for chronic wrist pain.
  • When performing this procedure through a dorsal approach we have been impressed by anatomic variations of the AIN.
  • The purpose of this study was to elucidate the anatomy of the AIN and PIN as encountered through a dorsal distal forearm incision.
  • A dorsal approach to the distal forearm was made to identify the anatomy of the PIN and AIN.
  • The location and diameter of all AIN branches were noted by using an operating stereoscopic microscope at x 25 magnification and a precision caliper.
  • RESULTS: The anatomy of the AIN was variable.
  • The average AIN diameter proximal to the PQ was 1.5 mm.
  • The average number of AIN motor branches was 4.2.
  • CONCLUSIONS: Resection of the AIN at a point 4 cm proximal to the proximal point of the ulnar head would denervate completely the PQ in our cadaver population.
  • Division of the AIN 2 cm proximal to the ulnar head would spare most of the PQ motor branches.

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  • (PMID = 16344179.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Watanabe M, Ayugase J: Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice. J Food Sci; 2010 Nov-Dec;75(9):H294-9
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  • Mice (C57BL/KsJ-lepr(db)/lepr(db), db/db) were fed a diet containing 0%, 5%, or 10% BS based on AIN-93G for 21 d.
  • Plasma parameters, such as total cholesterol, arteriosclerotic index, thiobarbituric acid reactive substances (TBARS), and the HbA1c concentration of whole blood in the diabetic BS-fed groups were lower than those in the diabetic control (AIN-93G) group.

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  • [Copyright] © 2010 Institute of Food Technologists®
  • (PMID = 21535603.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthocyanins; 0 / Bile Acids and Salts; 0 / Blood Glucose; 0 / Flavonoids; 0 / Hemoglobin A, Glycosylated; 0 / Hypoglycemic Agents; 0 / Thiobarbituric Acid Reactive Substances; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol; EC 1.1.1.- / Hydroxymethylglutaryl CoA Reductases; EC 1.14.13.17 / Cholesterol 7-alpha-Hydroxylase; EC 1.14.13.17 / Cyp7a1 protein, mouse
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12. Al-Sarraj T, Saadi H, Volek JS, Fernandez ML: Metabolic syndrome prevalence, dietary intake, and cardiovascular risk profile among overweight and obese adults 18-50 years old from the United Arab Emirates. Metab Syndr Relat Disord; 2010 Feb;8(1):39-46
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  • METHODS: We recruited 227 overweight/obese Emirati adults living in the city of Al-Ain, Emirati of Abu Dhabi to screen for the metabolic syndrome and to assess for the most relevant criteria for the metabolic syndrome in this population.
  • [MeSH-major] Metabolic Syndrome X / diagnosis. Obesity / diagnosis

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  • (PMID = 19929603.001).
  • [ISSN] 1557-8518
  • [Journal-full-title] Metabolic syndrome and related disorders
  • [ISO-abbreviation] Metab Syndr Relat Disord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cholesterol, HDL; 0 / Cholesterol, LDL
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13. Appel GB: The treatment of acute interstitial nephritis: More data at last. Kidney Int; 2008 Apr;73(8):905-7
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  • Acute interstitial nephritis (AIN) is an uncommon form of acute renal failure that is usually medication related.
  • The study by González et al., although it has limitations, provides solid support for the early use of corticosteroids in the treatment of drug-related AIN.

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  • [CommentOn] Kidney Int. 2008 Apr;73(8):940-6 [18185501.001]
  • (PMID = 18379525.001).
  • [ISSN] 1523-1755
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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14. Byun JS, Lee SS: Effect of soybeans and sword beans on bone metabolism in a rat model of osteoporosis. Ann Nutr Metab; 2010;56(2):106-12
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  • METHODS: Seven-week-old female Sprague-Dawley rats were raised for 2 weeks on a calcium-free diet based on the American Institute of Nutrition (AIN)-93M diets.

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20110670.001).
  • [ISSN] 1421-9697
  • [Journal-full-title] Annals of nutrition & metabolism
  • [ISO-abbreviation] Ann. Nutr. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Biomarkers; 0 / Tumor Necrosis Factor-alpha; 104982-03-8 / Osteocalcin; 90032-33-0 / deoxypyridinoline
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15. Pantanowitz L, Leiman G, Dezube BJ: Editorial comment: screening for anal dysplasia--are we on the same page? AIDS Read; 2009 May;19(5):182-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Editorial comment: screening for anal dysplasia--are we on the same page?
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. HIV Infections / diagnosis. Mass Screening. Precancerous Conditions / diagnosis
  • [MeSH-minor] Anal Canal / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / prevention & control. Humans. Male. Washington / epidemiology

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  • [CommentOn] AIDS Read. 2009 May;19(5):178-86 [19554736.001]
  • (PMID = 19554737.001).
  • [ISSN] 1053-0894
  • [Journal-full-title] The AIDS reader
  • [ISO-abbreviation] AIDS Read
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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16. Bissar-Tadmouri N, Tadmouri GO: Bibliometric analyses of biomedical research outputs in Lebanon and the United Arab Emirates (1988-2007). Saudi Med J; 2009 Jan;30(1):130-9
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  • In Lebanon, most of the citations originated from the capital city of Beirut, mainly the American University of Beirut.
  • In the UAE, most of the biomedical publications originate from Al-Ain University.
  • In the UAE, the plateau phase for biomedical research output size could be due to the limitation of most of the research in the country to Al-Ain University.

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  • (PMID = 19139787.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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17. Cörekçi S, Usanmaz D, Tekeli Z, Cakmak M, Ozçelik S, Ozbay E: Surface morphology of Al0.3Ga0.7N/Al2O3-high electron mobility transistor structure. J Nanosci Nanotechnol; 2008 Feb;8(2):640-4
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  • We present surface properties of buffer films (AIN and GaN) and Al0.3Gao.zN/Al2O3-High Electron Mobility Transistor (HEMT) structures with/without AIN interlayer grown on High Temperature (HT)-AIN buffer/Al2O3 substrate and Al2O3 substrate.
  • HT-AIN buffer layer can have a significant impact on the surface morphology of Al0.3Ga0.7N/Al2O3-HEMT structures.

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  • (PMID = 18464384.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. Campbell JK, Stroud CK, Nakamura MT, Lila MA, Erdman JW Jr: Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. J Nutr; 2006 Nov;136(11):2813-9
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  • To evaluate interrelations between phytofluene, lycopene, or tomato powder consumption and androgen status, 8-wk-old male F344 rats (fed a control AIN 93G diet) were castrated or sham-operated and subsequently provided with daily oral supplementation of phytofluene or lycopene ( approximately 0.7 mg/d) or fed a 10% tomato powder supplemented diet (AIN 93G) for 4 d.

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  • (PMID = 17056806.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 112649-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FABP3 protein, rat; 0 / Fatty Acid-Binding Proteins; 0 / PPAR gamma; 0 / RNA, Messenger; 08J2K08A3Y / Dihydrotestosterone; 36-88-4 / Carotenoids; 3XMK78S47O / Testosterone; 6NUO4W7YQ6 / phytofluene; EC 1.1.- / 17-Hydroxysteroid Dehydrogenases; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / Cyp3a1 protein, rat; EC 1.14.14.1 / Cytochrome P-450 CYP2B1; EC 1.14.14.1 / Cytochrome P-450 CYP3A; SB0N2N0WV6 / lycopene
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19. Kinser S, Li M, Jia Q, Pestka JJ: Truncated deoxynivalenol-induced splenic immediate early gene response in mice consuming (n-3) polyunsaturated fatty acids. J Nutr Biochem; 2005 Feb;16(2):88-95
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  • Mice were fed AIN-93G diet containing 1% corn oil (CO) plus 6% oleic acid (control) or a diet containing 1% CO, 2% fish oil enriched in the (n-3)-PUFAs docosahexaenoic and eicosapentaenoic acid and 4% oleic acid.


20. Himmel HJ: Possible pathways of CVD processes leading to III-V semiconductors via a two-dimensional growth. Chemphyschem; 2005 Apr;6(4):706-13
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  • Because some of the systems calculated herein contain a substantial number of atoms (up to 144), it is limited to intermediates on the way to solid AIN.
  • The structures are compared with that of solid AIN in its most stable Wurzit-type structure.

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  • (PMID = 15881587.001).
  • [ISSN] 1439-4235
  • [Journal-full-title] Chemphyschem : a European journal of chemical physics and physical chemistry
  • [ISO-abbreviation] Chemphyschem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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21. Kruijt B, van der Snoek EM, Sterenborg HJ, Amelink A, Robinson DJ: A dedicated applicator for light delivery and monitoring of PDT of intra-anal intraepithelial neoplasia. Photodiagnosis Photodyn Ther; 2010 Mar;7(1):3-9
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  • [Title] A dedicated applicator for light delivery and monitoring of PDT of intra-anal intraepithelial neoplasia.
  • The objective of this study was to develop an applicator for delivery of light and monitoring of photodynamic therapy (PDT) in the anal cavity for treatment of anal intraepithelial neoplasia grade III (AIN III), which can progress to invasive anal cancer.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / drug therapy. Carcinoma in Situ / diagnosis. Carcinoma in Situ / drug therapy. Lighting / instrumentation. Photochemotherapy / instrumentation. Photosensitizing Agents / administration & dosage

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  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20230986.001).
  • [ISSN] 1873-1597
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Photosensitizing Agents
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22. Abdel Rahman AT, Hafez SF, Abdelhakam SM, Ali-Eldin ZA, Esmat IM, Elsayed MS, Aboul-Fotouh A: Antimicrobial resistant bacteria among health care workers in intensive care units at Ain Shams University Hospitals. J Egypt Soc Parasitol; 2010 Apr;40(1):71-83
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  • [Title] Antimicrobial resistant bacteria among health care workers in intensive care units at Ain Shams University Hospitals.

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  • (PMID = 20503587.001).
  • [ISSN] 1110-0583
  • [Journal-full-title] Journal of the Egyptian Society of Parasitology
  • [ISO-abbreviation] J Egypt Soc Parasitol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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23. Elalfy MS, Abdin IA, El Safy UR, Ibrahim AS, Ebeid FS, Salem DS: Cardiac events and cardiac T2* in Egyptian children and young adults with beta-thalassemia major taking deferoxamine. Hematol Oncol Stem Cell Ther; 2010;3(4):174-8
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  • DESIGN AND SETTING: Prospective, observational, 10-year follow-up of patients attending Ain Shams Thalassemia Unit, Cairo, Egypt.

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  • (PMID = 21150236.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Benzoates; 0 / Pyridones; 0 / Siderophores; 0 / Triazoles; 2BTY8KH53L / deferiprone; 9007-73-2 / Ferritins; J06Y7MXW4D / Deferoxamine; V8G4MOF2V9 / deferasirox
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24. Dey P, Sharma N, Samanta S: Fractal dimension of cervical intraepithelial lesions on cytology smear. Anal Quant Cytol Histol; 2010 Dec;32(6):320-2
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  • [Title] Fractal dimension of cervical intraepithelial lesions on cytology smear.
  • OBJECTIVE: To explore the role of fractal dimension (FD) in distinguishing normal and different grades of cervical intraepithelial lesions.
  • STUDY DESIGN: We selected 15 cases each of normal samples and low-grade intraepithelial lesions (LSIL) and 14 cases of high-grade intraepithelial lesions (HSIL).
  • The LSIL diagnosis was verified by two cytopathologists.

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  • (PMID = 21456343.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Al-Muhairi SS, Zoubeidi TA, Ellis ME, Safa WF, Joseph J: Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates. Saudi Med J; 2006 Jul;27(7):1044-8
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  • [Title] Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates.
  • METHODS: We retrospectively analyze the data collected from all inpatients over the age of 16 years with a diagnosis of pneumonia in Tawam Hospital, Al-Ain, United Arab Emirates between the years 1997 and 2002.
  • [MeSH-major] Pneumonia / diagnosis

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  • (PMID = 16830028.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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26. Caers J, Peeters P, Vanden Houte K, Sennesael J, Van der Niepen P, Verbeelen D: Acute interstitial nephritis associated with salmonellosis. Eur J Intern Med; 2006 May;17(3):217-9
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  • Acute interstitial nephritis (AIN) is a common cause of acute renal failure.
  • We report a case of AIN, confirmed by renal biopsy, that developed in a patient with typhoid fever due to a Salmonella hadar infection.
  • AIN secondary to Salmonella infection is a rare complication that has only been described twice in the literature.
  • Salmonella should be added to the list of possible causes of AIN.

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  • (PMID = 16618461.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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27. Yang K, Lamprecht SA, Shinozaki H, Fan K, Yang W, Newmark HL, Kopelovich L, Edelmann W, Jin B, Gravaghi C, Augenlicht L, Kucherlapati R, Lipkin M: Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. J Nutr; 2008 Sep;138(9):1658-63
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  • We have demonstrated that a Western-style diet (WD) with low levels of calcium and cholecalciferol and high levels of (n-6) PUFA, increased the incidence of neoplasia in mouse intestine compared with a standard AIN-76A diet; models included wild-type mice and mice with targeted mutations.
  • In the present study, adenomatous polyposis coli (Apc)(1638N/+) mice carrying a heterozygous Apc mutation were fed either an AIN-76A diet, a WD, or a WD supplemented with calcium and cholecalciferol (WD/Ca/VitD3).
  • Feeding WD to Apc(1638N/+) mice not only enhanced cyclin D1 expression in colonic epithelium compared with AIN-76A treatment as previously reported but also significantly increased the expression of the antiapoptotic protein B-cell lymphoma 2 (Bcl-2) concomitantly with a decrease in the proapoptotic Bcl2-associated X protein and the number of apoptotic epithelial cells.
  • Importantly, Apc(1638N/+) mice fed the WD/Ca/VitD3 diet did not develop colonic tumors, further indicating that dietary calcium and cholecalciferol have a key role in the chemoprevention of colorectal neoplasia in this mouse model of human colon cancer.

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  • (PMID = 18716166.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA84301; United States / NIEHS NIH HHS / ES / ES-11040; United States / NCI NIH HHS / CN / N01-CN-43302; United States / NCI NIH HHS / CN / N01-CN-43308; United States / NCI NIH HHS / CA / U54-CA100926
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Calcium, Dietary; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; 136601-57-5 / Cyclin D1; 1C6V77QF41 / Cholecalciferol
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28. Ramos MI, Siqueira EM, Isomura CC, Barbosa AM, Arruda SF: Bocaiuva (Acrocomia aculeata (Jacq.) Lodd) improved Vitamin A status in rats. J Agric Food Chem; 2007 Apr 18;55(8):3186-90
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  • After the depletion period, the vitamin A deficient rats were separated into two groups and fed an AIN-93G modified diet, which contained 14 400 microg of pure beta-carotene (beta-carotene diet) or 13 475 microg of beta-carotene from 275 g of bocaiuva pulp (bocaiuva diet) per 1 kg of the diet as a vitamin A source.

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  • (PMID = 17373815.001).
  • [ISSN] 0021-8561
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 01YAE03M7J / beta Carotene
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29. Darvishian F, Stier EA, Soslow RA, Lin O: Immunoreactivity of p16 in anal cytology specimens: histologic correlation. Cancer; 2006 Feb 25;108(1):66-71
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  • [Title] Immunoreactivity of p16 in anal cytology specimens: histologic correlation.
  • BACKGROUND: Cytology has been proposed as a potential screening tool in the evaluation of squamous anorectal disease in view of the morphologic similarities between anal and cervical squamous lesions.
  • Previous studies have demonstrated that p16 overexpression correlates with the degree of dysplasia in the uterine cervix with promising results.
  • Due to potential diagnostic pitfalls in anal cytology, p16 overexpression in these specimens was studied.
  • RESULTS: Twenty-eight of the 43 cases demonstrated the presence of squamous cells immunoreactive for p16 in cytology specimens.
  • The p16-positive cells were identified in cases of low-grade squamous intraepithelial lesion (LSIL) (n = 3 cases), high-grade squamous intraepithelial lesion (HSIL) (n = 22 cases), and invasive squamous carcinoma (n = 1 case), and in 2 cases with negative follow-up biopsies.
  • The sensitivity and specificity of p16 immunoreactivity in the detection of anal intraepithelial neoplasia or carcinoma were 72% and 71%, respectively.
  • CONCLUSIONS: The presence of p16 immunoreactivity is a good predictor of dysplasia in anal specimens.
  • [MeSH-major] Anus Neoplasms / pathology. Biomarkers, Tumor / analysis. Carcinoma in Situ / pathology. Neoplasms, Squamous Cell / pathology

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 16404747.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
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30. Capsoni F, Sarzi-Puttini P, Zanella A: Primary and secondary autoimmune neutropenia. Arthritis Res Ther; 2005;7(5):208-14
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  • In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious infections and exhibits a self-limited course.
  • Secondary AIN is more commonly seen in adults and underlying causes include collagen disorders, drugs, viruses and lymphoproliferative disorders.
  • In most patients with AIN, antibodies recognize antigens located on the IgG Fc receptor type 3b but other target antigens have been recently identified in secondary AIN.
  • Granulocyte colony-stimulating factor is a proven treatment in patients with AIN of all types and is now preferred to other possible therapies.

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  • (PMID = 16207350.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Antigens, CD; 0 / Autoantigens; 0 / FCGR3B protein, human; 0 / GPI-Linked Proteins; 0 / Immunoglobulins, Intravenous; 0 / Isoantigens; 0 / Receptors, IgG; 0 / neutrophil-specific antigen NA1, human; 143011-72-7 / Granulocyte Colony-Stimulating Factor
  • [Number-of-references] 67
  • [Other-IDs] NLM/ PMC1257445
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31. Dlugos CA: Analyses of smooth endoplasmic reticulum of cerebellar parallel fibers in aging, ethanol-fed rats. Alcohol; 2005 Jan;35(1):67-73
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  • Male Fischer 344 rats (n = 120; age = 12 months old) were randomly divided into three dietary groups (40 rats per group) and fed rat chow, the AIN-93M liquid control diet, or the AIN-93M liquid ethanol diet (without water) for 5, 10, 20, or 40 weeks (30 rats per time point).

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  • (PMID = 15922139.001).
  • [ISSN] 0741-8329
  • [Journal-full-title] Alcohol (Fayetteville, N.Y.)
  • [ISO-abbreviation] Alcohol
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / AA13104
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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32. Moselhy SS, Demerdash SH: Serum free L-carnitine in association with myoglobin as a diagnostic marker of acute myocardial infarction. Clin Biochem; 2009 Jan;42(1-2):78-82
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  • BACKGROUND: Early diagnosis of acute myocardial infarction (AMI) in patients with chest pain is necessary to initiate appropriate treatment.
  • Elevation of ST-segment in ECG is the only marker that cardiologists depend on in diagnosis.
  • DESIGN AND METHODS: In the present study serum total CK activity and CK-MB, Myo, and free L-carnitine levels were determined in 90 patients admitted to the ICU at Ain Shams University Hospital and correlated the sensitivity and specificity of each parameter.
  • For this reason, serum free L-carnitine can be used as a good predictor for AMI diagnosis from other diseases.
  • [MeSH-major] Carnitine / blood. Myocardial Infarction / blood. Myocardial Infarction / diagnosis. Myoglobin / blood


33. Davey E, d'Assuncao J, Irwig L, Macaskill P, Chan SF, Richards A, Farnsworth A: Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study. BMJ; 2007 Jul 7;335(7609):31
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  • MAIN OUTCOME MEASURES: Primary outcome was accuracy of slides for detecting squamous lesions.
  • Secondary outcomes were rate of unsatisfactory slides, distribution of squamous cytological classifications, and accuracy of detecting glandular lesions.
  • More slides were classified as abnormal by imager read cytology (7.4% v 6.0% overall and 2.8% v 2.2% for cervical intraepithelial neoplasia of grade 1 or higher).
  • Among 550 patients in whom imager read cytology was cervical intraepithelial neoplasia grade 1 or higher and conventional cytology was less severe than grade 1, 133 of 380 biopsy samples taken were high grade histology.
  • Among 294 patients in whom imager read cytology was less severe than cervical intraepithelial neoplasia grade 1 and conventional cytology was grade 1 or higher, 62 of 210 biopsy samples taken were high grade histology.
  • CONCLUSION: The ThinPrep Imager detects 1.29 more cases of histological high grade squamous disease per 1000 women screened than conventional cytology, with cervical intraepithelial neoplasia grade 1 as the threshold for referral to colposcopy.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cervical Intraepithelial Neoplasia / pathology. Uterine Cervical Neoplasms / pathology


34. Bener A, Saad AG, Micallef R, Ghuloum S, Sabri S: Sociodemographic and clinical characteristics of patients with dissociative disorders in an Arabian society. Med Princ Pract; 2006;15(5):362-7
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  • These patients were recruited from Al-Ain and Tawam Teaching Hospitals and Al-Jahili Primary Health Care Centers in Al-Ain, United Arab Emirates.

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  • (PMID = 16888394.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Switzerland
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35. Moran MG, Barkley TW Jr, Hughes CB: Screening and management of anal dysplasia and anal cancer in HIV-infected patients: a guide for practice. J Assoc Nurses AIDS Care; 2010 Sep-Oct;21(5):408-16
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  • [Title] Screening and management of anal dysplasia and anal cancer in HIV-infected patients: a guide for practice.
  • People living with HIV infection have a significantly higher rate of anal cancer as compared with that of uninfected people.
  • It is believed that high-grade anal dysplasia secondary to human papillomavirus infection is a precursor to anal cancer.
  • Considering this, screening and treatment of high-grade anal dysplasia is a possible means of preventing the development of anal cancer.
  • No national or international guidelines exist to guide practice for screening and management of anal dysplasia.
  • On the basis of a review of research and expert recommendations, a guide to practice for screening and management of anal dysplasia and anal cancer is made for clinicians.
  • [MeSH-major] Anus Neoplasms / complications. HIV Infections / complications

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  • [Copyright] (c) 2010 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20409734.001).
  • [ISSN] 1552-6917
  • [Journal-full-title] The Journal of the Association of Nurses in AIDS Care : JANAC
  • [ISO-abbreviation] J Assoc Nurses AIDS Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Bommareddy A, Zhang X, Schrader D, Kaushik RS, Zeman D, Matthees DP, Dwivedi C: Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. Nutr Cancer; 2009;61(2):276-83
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  • Apc(Min) mice were divided into five different groups, fed with control (AIN-93M meal), corn meal, flaxseed meal, corn oil, and flaxseed oil supplemented diets.

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  • (PMID = 19235044.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Fatty Acids; 0 / Fatty Acids, Omega-3; 0 / Lignans; 0RBV727H71 / alpha-Linolenic Acid; 8001-26-1 / Linseed Oil; 8001-30-7 / Corn Oil; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; MO0N1J0SEN / Azoxymethane
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37. Hong H, Kim WJ, Yoo SH, Abanto OD, Kim TJ, Kim YJ, Jung BM, Yun SS, Hwang SG: Dietary ungerminated and germinated soybean supplementation improves bone mineralization and strength in growing male rats. J Med Food; 2010 Jun;13(3):640-9
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  • Forty-nine 6-week-old male Sprague-Dawley rats were assigned to seven dietary treatment groups: AIN 93G (control); control with UGS powder at 3% (UGS-L), 15% (UGS-M), or 30% (UGS-H); and control with GS powder at 3% (GS-L), 15% (GS-M), or 30% (GS-H).

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  • (PMID = 20438320.001).
  • [ISSN] 1557-7600
  • [Journal-full-title] Journal of medicinal food
  • [ISO-abbreviation] J Med Food
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Preparations; 104982-03-8 / Osteocalcin
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38. Foad I, Sharawy I, Mostafa E, Margergis M, Hussein T: Concurrent cisplatin/radiation followed by adjuvant cisplatin/paclitaxel in treatment of patients with stage IB grade 3, IC and IIA endometrial carcinoma. J Egypt Natl Canc Inst; 2007 Jun;19(2):163-9
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  • RESULTS: Between May 2000 and March 2002, a total of 18 patients with pathologically confirmed endometrial carcinoma, presented to Radiation Oncology & Nuclear Medicine Department, Ain Shams University Hospitals, were enrolled in this study.
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Combined Modality Therapy. Feasibility Studies. Female. Follow-Up Studies. Humans. Hysterectomy. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / therapy. Neoplasm Staging. Ovariectomy. Paclitaxel / administration & dosage. Prognosis. Radiotherapy Dosage. Survival Rate. Treatment Outcome

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  • (PMID = 19034346.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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39. Bener A, Ghaffar A, Azab A, Sankaran-Kutty M, Toth F, Lovasz G: The impact of four-wheel drives on traffic disability and deaths compared to passenger cars. J Coll Physicians Surg Pak; 2006 Apr;16(4):257-60
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  • PLACE AND DURATION OF STUDY: Al-Ain and Tawam Hospital, UAE, during a period from 1st January to 31st December 2000.
  • [MeSH-major] Accidents, Traffic / mortality. Automobiles / classification. Cause of Death. Wounds and Injuries / diagnosis. Wounds and Injuries / mortality

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  • (PMID = 16624187.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Pakistan
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40. Nabhan AF: A randomized clinical trial of the effects of isosorbide mononitrate on bone formation and resorption in post-menopausal women: a pilot study. Hum Reprod; 2006 May;21(5):1320-4
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  • METHODS: A prospective randomized trial was carried out in the Department of Obstetrics & Gynecology, Ain Shams University, Egypt.

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  • [RetractionIn] Hum Reprod. 2006 Oct;21(10):2466 [16997941.001]
  • (PMID = 16410328.001).
  • [ISSN] 0268-1161
  • [Journal-full-title] Human reproduction (Oxford, England)
  • [ISO-abbreviation] Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Retracted Publication
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Collagen Type I; 0 / Nitric Oxide Donors; 0 / Peptides; 0 / collagen type I trimeric cross-linked peptide; 16051-77-7 / isosorbide-5-mononitrate; EC 3.1.3.1 / Alkaline Phosphatase; IA7306519N / Isosorbide Dinitrate
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41. Duffy PH, Lewis SM, Mayhugh MA, Trotter RW, Hass BS, Latendresse JR, Thorn BT, Tobin G, Feuers RJ: Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes. Nutr Res; 2008 Jan;28(1):36-42
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  • [Title] Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes.
  • The primary purpose of this study was to evaluate the effects of age and long-term dietary reduction on neoplastic diseases in rats fed the AIN-93M purified diet.
  • Male Sprague-Dawley rats assigned to 2 groups, ad libitum (AL) and dietary restricted (DR), were fed the AIN-93M (casein protein) diet free choice and reduced in amount by 31%, respectively.

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  • (PMID = 19083386.001).
  • [ISSN] 1879-0739
  • [Journal-full-title] Nutrition research (New York, N.Y.)
  • [ISO-abbreviation] Nutr Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caseins; 0 / Dietary Proteins
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42. de Góis NM, Costa RR, Kesselring F, de Freitas VG, Ribalta JC, Kobata MP, Taha NS: Grade 3 vulvar and anal intraepithelial neoplasia in a HIV seropositive child--therapeutic result: case report. Clin Exp Obstet Gynecol; 2005;32(2):138-40
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  • [Title] Grade 3 vulvar and anal intraepithelial neoplasia in a HIV seropositive child--therapeutic result: case report.
  • A case report of a HIV seropositive 8-year-old child with vulvar and anal border neoplasia, both grade 3, and the adopted therapeutic management are presented.
  • On physical examination a pigmented and elevated lesion was observed in the whole vulvar region extending to the anal region and intergluteal sulcus.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma / therapy. HIV Infections / diagnosis. HIV Infections / drug therapy. Vulvar Neoplasms / therapy


43. Cho YY, Kwon EY, Kim HJ, Park YB, Lee KT, Park T, Choi MS: Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E(-/-) mice. Food Chem Toxicol; 2009 Jul;47(7):1550-5
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  • The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks.

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  • (PMID = 19361550.001).
  • [ISSN] 1873-6351
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Trans Fatty Acids; 8001-26-1 / Linseed Oil; EC 1.1.1.- / Hydroxymethylglutaryl CoA Reductases; EC 2.3.1.26 / Sterol O-Acyltransferase
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44. Fan RX, Lü SW, DU YP, Hou MJ, Zhu HL: [Anti-atherosclerotic effect of betaine in apolipoprotein E-deficient mice]. Zhonghua Yu Fang Yi Xue Za Zhi; 2008 Oct;42(10):742-7
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  • The control group and model group were fed AIN-93G diet.
  • Three betaine groups were fed AIN-93G diet supplemented with 1, 2, 4 g betaine/100 g diet, respectively.

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  • (PMID = 19178837.001).
  • [ISSN] 0253-9624
  • [Journal-full-title] Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
  • [ISO-abbreviation] Zhonghua Yu Fang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Chemokine CCL2; 0 / Tumor Necrosis Factor-alpha; 3SCV180C9W / Betaine
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45. Moscicki AB, Schiffman M, Kjaer S, Villa LL: Chapter 5: Updating the natural history of HPV and anogenital cancer. Vaccine; 2006 Aug 31;24 Suppl 3:S3/42-51
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  • The importance of the transformation zone in cervical cancer has been extended to other HPV-induced cancers such as anal or tonsillar cancers.
  • Natural history studies show that HPV with normal cervical cytology and cervical intraepithelial neoplasia (CIN) grade 1 behave similarly, with the majority of both showing regression.
  • [MeSH-major] Anus Neoplasms / virology. Genital Neoplasms, Female / virology. Genital Neoplasms, Male / virology. Neoplasms / virology. Papillomavirus Infections / complications

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  • (PMID = 16950017.001).
  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R37 CA051323
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 45
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46. Eckert L: Screening for anal dysplasia in women with cervical, vaginal, or vulvar dysplasia: yes, no, maybe? Obstet Gynecol; 2010 Sep;116(3):566-7
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  • [Title] Screening for anal dysplasia in women with cervical, vaginal, or vulvar dysplasia: yes, no, maybe?
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Genital Neoplasms, Female / complications

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  • [CommentOn] Obstet Gynecol. 2010 Sep;116(3):578-82 [20733438.001]
  • (PMID = 20733435.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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47. Cerqueira FM, Kowaltowski AJ: Commonly adopted caloric restriction protocols often involve malnutrition. Ageing Res Rev; 2010 Oct;9(4):424-30
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  • We provide evidence that the most commonly adopted caloric restriction protocol, a 40% restriction of the AIN-93 diet without vitamin or mineral supplementation, leads to malnutrition in both mice and rats.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20493280.001).
  • [ISSN] 1872-9649
  • [Journal-full-title] Ageing research reviews
  • [ISO-abbreviation] Ageing Res. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Micronutrients
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48. El-Sayed HM, El-Lamie IK, Ibrahim AM, El-Lamie KI: Vaginal reconstruction with sigmoid colon in vaginal agenesis. Int Urogynecol J Pelvic Floor Dysfunct; 2007 Sep;18(9):1043-7
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  • From June 2000 to June 2005, 26 patients with congenital vaginal agenesis were evaluated and treated with sigmoid colon reconstruction at Ain Shams University Maternity Hospital as a primary procedure in 17 patients and a secondary procedure in 9 patients after previous failed Abbe-McIndoe vaginoplasty elsewhere.

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  • (PMID = 17203327.001).
  • [Journal-full-title] International urogynecology journal and pelvic floor dysfunction
  • [ISO-abbreviation] Int Urogynecol J Pelvic Floor Dysfunct
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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49. Bouzidi A, Souahi F, Hanini S: Sorption behavior of cesium on Ain Oussera soil under different physicochemical conditions. J Hazard Mater; 2010 Dec 15;184(1-3):640-6
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  • [Title] Sorption behavior of cesium on Ain Oussera soil under different physicochemical conditions.
  • In the present study, the sorption behavior of cesium was investigated in Ain Oussera soil around the Es-Salam reactor facility.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20869168.001).
  • [ISSN] 1873-3336
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Soil Pollutants; 1KSV9V4Y4I / Cesium
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50. Palefsky J: Human papillomavirus and anal neoplasia. Curr HIV/AIDS Rep; 2008 May;5(2):78-85
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  • [Title] Human papillomavirus and anal neoplasia.
  • Anal cancer is a rare disease in the general population, but the incidence of anal cancer is higher in certain at-risk groups, such as men who have sex with men (MSM), and immunosuppressed individuals, including those with HIV infection.
  • Among HIV-positive MSM, the incidence of anal cancer may be as high as 10 times greater than current rates of cervical cancer in the general population of women.
  • Anal cancer is associated with human papillomavirus (HPV) infection and may be preceded by high-grade anal intraepithelial neoplasia (HGAIN).
  • HGAIN and anal HPV infection are both highly prevalent in groups at risk for anal cancer.
  • Current issues include determining the effect of antiretroviral therapy on the natural history of HGAIN and the incidence of anal cancer, optimizing diagnostic and therapeutic approaches to HGAIN, and determining the potential for prophylactic HPV vaccines to prevent anal HPV infection and anal cancer in at-risk groups.
  • [MeSH-major] Anus Neoplasms. Carcinoma in Situ. Papillomavirus Infections
  • [MeSH-minor] Anus Diseases / epidemiology. Anus Diseases / virology. Female. HIV Infections / complications. Homosexuality, Male. Humans. Male. Papillomaviridae / isolation & purification

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  • (PMID = 18510893.001).
  • [ISSN] 1548-3568
  • [Journal-full-title] Current HIV/AIDS reports
  • [ISO-abbreviation] Curr HIV/AIDS Rep
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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51. Clow KA, Treberg JR, Brosnan ME, Brosnan JT: Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis. J Nutr; 2008 Sep;138(9):1641-6
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  • In study 2, dams and, following weaning, pups were fed an AIN-93G (betaine-free) or an AIN-93G betaine-supplemented diet (0.3%) to determine the source of the transient increase in betaine levels previously observed.

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  • (PMID = 18716163.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 3SCV180C9W / Betaine
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52. Reeves PG, Leary PD, Gregoire BR, Finley JW, Lindlauf JE, Johnson LK: Selenium bioavailability from buckwheat bran in rats fed a modified AIN-93G torula yeast-based diet. J Nutr; 2005 Nov;135(11):2627-33
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  • [Title] Selenium bioavailability from buckwheat bran in rats fed a modified AIN-93G torula yeast-based diet.
  • The responses produced from buckwheat bran Se were compared with a standard response curve generated by feeding graded amounts of Se as sodium selenite (Na(2)SeO(3); Na selenite) or selenomethionine (SeMet) in a newly reformulated AIN-93G-Torula yeast diet with a more balanced nutrient composition than older diets of this nature.

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  • (PMID = 16251622.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Proteins; 964MRK2PEL / Selenomethionine; EC 1.11.1.9 / Glutathione Peroxidase; H6241UJ22B / Selenium; HIW548RQ3W / Sodium Selenite
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53. Mahto M, Nathan M, O'Mahony C: More than a decade on: review of the use of imiquimod in lower anogenital intraepithelial neoplasia. Int J STD AIDS; 2010 Jan;21(1):8-16
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  • [Title] More than a decade on: review of the use of imiquimod in lower anogenital intraepithelial neoplasia.
  • To assess the effectiveness of 5% imiquimod cream (IQ) in the treatment of vulvar, penile and anal intraepithelial neoplasias (VIN, PIN and AIN), we searched Medline, Embase, PubMed and Cochrane Library databases.
  • Use of IQ in PIN and AIN were only supported by cohort studies (two each for PIN and AIN) and case reports (15 for PIN and 3 for AIN).
  • On pooled analysis of RCTs, uncontrolled and cohort studies, the mean complete response (CR) rate for VIN, PIN and AIN were 51%, 70% and 48%, respectively.
  • The mean partial response (PR) rate for VIN, PIN and AIN were 25%, 30% and 34% respectively.
  • The recurrence (RR) rate for VIN, PIN and AIN were 16%, 0% and 36%, respectively.
  • The follow-up period for VIN, PIN and AIN ranged from 2 to 32 months, 10 to 12 months and 11 to 39 months, respectively.
  • Although the results for PIN look the best, the strongest evidence regarding efficacy of IQ in anogenital intraepithelial neoplasia is for VIN supported by RCTs.
  • Evidence for use of IQ in AIN was essentially limited to HIV-positive men who have sex with men.
  • [MeSH-major] Adjuvants, Immunologic / therapeutic use. Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. Penile Neoplasms / drug therapy. Vulvar Neoplasms / drug therapy

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  • (PMID = 20029061.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
  • [Number-of-references] 69
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54. Mrudula T, Suryanarayana P, Srinivas PN, Reddy GB: Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem Biophys Res Commun; 2007 Sep 21;361(2):528-32
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  • After induction, one group of diabetic rats were fed only the AIN-93 diet and the rest of the groups were fed with AIN-93 diet containing 0.002% or 0.01% curcumin or 0.5% turmeric for a period of 8 weeks.
  • The control rats received sham injection and fed on the AIN-93 diet.

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  • (PMID = 17662242.001).
  • [ISSN] 0006-291X
  • [Journal-full-title] Biochemical and biophysical research communications
  • [ISO-abbreviation] Biochem. Biophys. Res. Commun.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A; 5W494URQ81 / Streptozocin; IT942ZTH98 / Curcumin
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55. Ezzat WF, Shehata M, Kamal I, Riad MA: Adjustable laterofixation of the vocal fold in bilateral vocal fold paralysis. Laryngoscope; 2010 Apr;120(4):731-3
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  • METHODS: Twenty-one patients with recent bilateral VFP were treated by the modified laterofixation technique in Ain-Shams University hospitals between May 2007 and February 2009.

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  • (PMID = 20205242.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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56. Palefsky J: Biology of HPV in HIV infection. Adv Dent Res; 2006 Apr 01;19(1):99-105
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  • The risks for HPV-associated high-grade intra-epithelial neoplasia (IN) and cancer are also increased.
  • The prevalence of oral, anal, and cervical HPV infection in HIV-positive individuals compared with HIV-negative individuals increases with progressively lower CD4+ levels, as does incident high-grade IN.
  • This suggests a link between CNA and increased HPV-induced chromosomal instability mediated through de-repressed E6 and E7 expression consequent to loss of functional E2 protein.
  • There are few data to suggest a direct role for HIV in the pathogenesis of HPV-associated neoplasia, but HIV-associated attenuation of HPV-specific immune responses may allow for persistence of high-grade IN and sufficient time for accumulation of genetic changes that are important in progression to cancer.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / virology. HIV Infections / virology. Papillomaviridae / physiology. Papillomavirus Infections / complications. Uterine Cervical Neoplasms / virology
  • [MeSH-minor] AIDS-Related Opportunistic Infections / virology. Aneuploidy. Antiretroviral Therapy, Highly Active / adverse effects. Anus Neoplasms / complications. Anus Neoplasms / genetics. Anus Neoplasms / virology. CD4 Lymphocyte Count. Chromosomes, Human, Pair 3 / virology. Female. Humans. Male. Virus Integration

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  • (PMID = 16672559.001).
  • [ISSN] 1544-0737
  • [Journal-full-title] Advances in dental research
  • [ISO-abbreviation] Adv. Dent. Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / CA54053; United States / NIDCR NIH HHS / DE / DE07946; United States / NCI NIH HHS / CA / U01 CA66529; United States / NCI NIH HHS / CA / UO1 CA70019
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 78
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57. Strander B, Ryd W, Wallin KL, Wärleby B, Zheng B, Milsom I, Gharizadeh B, Pourmand N, Andersson-Ellström A: Does HPV-status 6-12 months after treatment of high grade dysplasia in the uterine cervix predict long term recurrence? Eur J Cancer; 2007 Aug;43(12):1849-55
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  • [Title] Does HPV-status 6-12 months after treatment of high grade dysplasia in the uterine cervix predict long term recurrence?
  • BACKGROUND: Women once treated for high grade cervical dysplasia have a high long term risk for developing new dysplasia or cancer.
  • OBJECTIVES: To investigate if human papilloma virus (HPV)-negativity after treatment of cervical dysplasia reduces the need for frequent long term follow up.
  • METHODS: Women with cervical intraepithelial neoplasi (CIN)2-3, treated for dysplasia and with recurrence of CIN2+ more than 2 years after treatment were compared with controls without recurrence, matched for age and date of treatment.
  • CONCLUSION: HPV-status 6-12 months after treatment of high grade dysplasia is of limited value for the design of long term follow up.

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  • (PMID = 17614272.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] ENG
  • [Grant] United States / NHGRI NIH HHS / HG / HG000205-190004; United States / NHGRI NIH HHS / HG / P01 HG000205; United States / NHGRI NIH HHS / HG / P01 HG000205-190004
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS151296; NLM/ PMC2933034
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58. Owens SR, Greenson JK: Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. Am J Surg Pathol; 2007 Feb;31(2):285-90
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  • [Title] Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas.
  • Anal canal carcinomas account for between 1% and 2% of all gastrointestinal carcinomas in the United States.
  • By far, the most common carcinoma in this site is squamous cell carcinoma, but the differential diagnosis typically includes poorly differentiated adenocarcinoma and well-differentiated neuroendocrine carcinoma or carcinoid tumor.
  • However, accurate diagnosis is imperative, because the treatment differs between squamous carcinoma (chemoradiation) and the other types of carcinoma (surgical therapy).
  • The p63 protein has been previously shown to be involved in epithelial proliferation and differentiation, and is known to be related to squamous carcinomas in many sites.
  • Therefore, we undertook to ascertain its usefulness in the diagnosis of squamous carcinomas in the anal canal.
  • We retrieved 24 anal squamous carcinomas, 68 colorectal adenocarcinomas (including a tissue microarray), and 32 colorectal neuroendocrine carcinomas from the archives at the University of Michigan, and immunostained them for the p63 antigen.
  • As a result, this immunohistochemical stain had a specificity of 98% and a positive predictive value of 92% for squamous cell carcinoma once invasive carcinoma had been established.
  • It also stained the dysplastic epithelial cells in adjacent areas of anal intraepithelial neoplasia.
  • We report that the p63 immunostain is a highly specific and useful tool in the diagnosis of carcinomas of the anal canal.
  • [MeSH-major] Anal Canal / metabolism. Anus Neoplasms / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. DNA-Binding Proteins / metabolism. Immunoenzyme Techniques / methods. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / metabolism. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Diagnosis, Differential. Humans. Predictive Value of Tests. Tissue Array Analysis. Transcription Factors

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  • (PMID = 17255774.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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59. Wang X, Zheng B, Zhang RR, Li S, Chen X, Mulvihill JJ, Lu X, Pang H, Liu H: Automated analysis of fluorescent in situ hybridization (FISH) labeled genetic biomarkers in assisting cervical cancer diagnosis. Technol Cancer Res Treat; 2010 Jun;9(3):231-42
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  • [Title] Automated analysis of fluorescent in situ hybridization (FISH) labeled genetic biomarkers in assisting cervical cancer diagnosis.
  • Among the available diagnostic methods to analyze the aneusomy of chromosomes 3 and X, fluorescence in situ hybridization (FISH) technology has demonstrated significant advantages in assisting clinicians to more accurately detect and diagnose cervical carcinoma at an early stage, in particular for the women at a high risk for progression of low-grade and high-grade squamous intra-epithelium lesions (LSIL and HSIL).
  • [MeSH-major] Biomarkers, Tumor / analysis. In Situ Hybridization, Fluorescence / methods. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / genetics
  • [MeSH-minor] Automation. Cervical Intraepithelial Neoplasia / diagnosis. Cervical Intraepithelial Neoplasia / genetics. Female. Humans. Vaginal Smears

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  • (PMID = 20441233.001).
  • [ISSN] 1533-0338
  • [Journal-full-title] Technology in cancer research & treatment
  • [ISO-abbreviation] Technol. Cancer Res. Treat.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA136700; United States / NCI NIH HHS / CA / R01 CA136700-01; United States / NCI NIH HHS / CA / CA136700
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS220245; NLM/ PMC2916642
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60. Bu SY, Lucas EA, Franklin M, Marlow D, Brackett DJ, Boldrin EA, Devareddy L, Arjmandi BH, Smith BJ: Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats. Osteoporos Int; 2007 Jul;18(7):931-42
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  • The ORX groups were assigned to control (AIN-93M) diet, 25% DP diet, or PTH (80 microg/kg) for 90 days.

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  • (PMID = 17554580.001).
  • [ISSN] 0937-941X
  • [Journal-full-title] Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
  • [ISO-abbreviation] Osteoporos Int
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Parathyroid Hormone
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61. Health Quality Ontario: Anal dysplasia screening: an evidence-based analysis. Ont Health Technol Assess Ser; 2007;7(4):1-43
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  • [Title] Anal dysplasia screening: an evidence-based analysis.
  • OBJECTIVE: This review considered the role of the anal Pap test as a screening test for anal dysplasia in patients at high risk of anal SCC.
  • CLINICAL NEED: TARGET POPULATION AND CONDITION Anal cancer, like cervical cancer, is a member of a broader group of anogenital cancers known to be associated with sexually transmitted viral HPV infection.
  • Sexual practices involving receptive anal intercourse lead to significantly elevated risk for anal dysplasia and cancer, particularly in those with immune dysfunctions.
  • Anal cancer is rare.
  • Certain segments of the population, however, such as HIV-positive men and women, other chronic immune-suppressed patients (e.g., after a transplant), injection drug users, and women with genital dysplasia /cancer, have a high susceptibility to anal cancer.
  • Those with the highest identified risk for anal cancer are HIV-positive homosexual and bisexual men, at a rate of 70 per 100,000 men.
  • The risk for anal cancer is reported to be increasing dramatically in HIV-positive males and females, particularly since the introduction of highly active antiretroviral therapy in the mid-1990s.
  • HEALTH TECHNOLOGY DESCRIPTION: Anal Pap test screening involves the blind insertion of a swab into the anal canal and fixing cells either on a slide or in fluid for cytological examination.
  • Anal cytology classified by the standardized Bethesda System is the same classification used for cervical cytology.
  • It has 4 categories: normal, atypical squamous cells of uncertain significance, or squamous intraepithelial lesions which are further classified into low- or high-grade lesions.
  • Unlike cervical cancer, there are no universally accepted guidelines or standards of care for anal dysplasia.
  • The New York State Department of Health AIDS Institute has recently recommended (March 2007) annual anal pap testing in high-risk groups.
  • That is, there is no reimbursement for anal Pap testing in men or women, and HPV screening tests for cervical or anal cancer are also not reimbursed.
  • FINDINGS: No direct evidence was found for the existence of controlled studies evaluating the effectiveness of anal Pap test screening programs for impact on anal cancer morbidity or mortality.
  • In addition, no studies were found on the use of HPV DNA testing in the screening or diagnostic setting for anal dysplasia.
  • The reported prevalence of HPV infection in high-risk groups, particularly HIV-positive males, however, was sufficiently high to preclude any utility of HPV testing as an adjunct to anal Pap testing.
  • Nine reports involving studies in the United States, United Kingdom, and Canada were identified that evaluated the performance characteristics of anal Pap test screening for anal dysplasia.
  • Estimates of anal Pap test sensitivity and specificity were highly variable, and depended on the varying prevalence of cytology abnormality and differential thresholds for abnormality for both cytology and histopathology.
  • CONCLUSIONS: No direct evidence exists to support the effectiveness of an anal Pap test screening program to reduce anal cancer mortality or morbidity.
  • Sexually transmitted HPV viral infection is currently the acknowledged common causative agent for both anal and cervical cancer.
  • Anal cancer rates in high-risk populations are approaching those of cervical cancer before the implementation of Pap testing.
  • The anal Pap test, although it has been mainly evaluated only in HIV-positive males, has similar operating characteristics of sensitivity and specificity as the cervical Pap test.
  • In general, the treatment options for precancer dysplasia in the cervix and the anus are similar, but treatment involving a definitive surgical resection in the anus is more limited because of the higher risk of complications.
  • A range of ablative therapies has been applied for anal dysplasia, but evidence on treatment effectiveness, tolerability and durability, particularly in the HIV-positive patient, is limited.

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  • (PMID = 23074504.001).
  • [ISSN] 1915-7398
  • [Journal-full-title] Ontario health technology assessment series
  • [ISO-abbreviation] Ont Health Technol Assess Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3377578
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62. Beli E, Li M, Cuff C, Pestka JJ: Docosahexaenoic acid-enriched fish oil consumption modulates immunoglobulin responses to and clearance of enteric reovirus infection in mice. J Nutr; 2008 Apr;138(4):813-9
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  • Mice were fed either AIN-93G control diet, containing 10 g/kg corn oil and 60 g/kg high oleic acid safflower oil, or AIN-93G, containing 10 g/kg corn oil and 60 g/kg DHA-enriched fish oil, for 4 wk and then orally gavaged with reovirus strain Type 1 Lang, (T1/L).

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  • (PMID = 18356340.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 58833
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids; 0 / Fatty Acids, Omega-3; 0 / Fish Oils; 0 / Immunoglobulins; 0 / Phospholipids; 25167-62-8 / Docosahexaenoic Acids; AAN7QOV9EA / Eicosapentaenoic Acid
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63. Palmerini E, Fan K, Yang K, Risio M, Edelmann W, Lipkin M, Biasco G: Piroxicam increases colon tumorigenesis and promotes apoptosis in Mlh1 +/- /Apc1638(N/+) mice. Anticancer Res; 2007 Nov-Dec;27(6B):3807-12
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  • MATERIALS AND METHODS: Mice were fed AIN-76A diet alone or premixed with piroxicam (60 ppm) for 9 weeks.
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Animals. Anti-Inflammatory Agents, Non-Steroidal / pharmacology. Apoptosis / drug effects. Apoptosis / genetics. Disease Models, Animal. Epithelial Cells / drug effects. Epithelial Cells / pathology. Genes, APC. Genetic Predisposition to Disease. Intestine, Small / drug effects. Intestine, Small / pathology. Mice. Mice, Mutant Strains. Nuclear Proteins / genetics. Random Allocation

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  • (PMID = 18225536.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-85164
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Mlh1 protein, mouse; 0 / Nuclear Proteins; 13T4O6VMAM / Piroxicam
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64. Baak JP, Kruse AJ, Robboy SJ, Janssen EA, van Diermen B, Skaland I: Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers. J Clin Pathol; 2006 Oct;59(10):1017-28
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  • [Title] Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.
  • The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance between factors that promote or reduce CIN development.
  • Such geography-specific epithelial evaluations of quantitative biomarkers emphasise the dynamic nature of a particular CIN lesion, thereby changing the art of static morphology grading into dynamic interpretation of the diseased tissue, with a strong prognostic effect.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cervical Intraepithelial Neoplasia / pathology. Uterine Cervical Neoplasms / pathology


65. Chen R, Pan S, Duan X, Nelson BH, Sahota RA, de Rham S, Kozarek RA, McIntosh M, Brentnall TA: Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia. Mol Cancer; 2010 Jun 15;9:149
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  • [Title] Elevated level of anterior gradient-2 in pancreatic juice from patients with pre-malignant pancreatic neoplasia.
  • BACKGROUND: Pancreatic intraepithelial neoplasias (PanINs) are precursors of malignant pancreatic cancer, an ideal stage for early cancer detection.

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  • (PMID = 20550709.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01DK081368; United States / NCI NIH HHS / CA / CA116296-02; United States / NCI NIH HHS / CA / K07 CA116296-02; United States / NCI NIH HHS / CA / K07 CA116296; United States / NCI NIH HHS / CA / R01CA107209; United States / NCI NIH HHS / CA / K07CA116296; United States / NCI NIH HHS / CA / K25CA137222
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proteins; EC 5.3.4.1 / AGR2 protein, human
  • [Other-IDs] NLM/ PMC2893103
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66. Sella R, Flomenblit L, Goldstein I, Kaplinsky C: Detection of anti-neutrophil antibodies in autoimmune neutropenia of infancy: a multicenter study. Isr Med Assoc J; 2010 Feb;12(2):91-6
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  • Primary AIN is characterized by neutrophil count < 500 ml and a benign self-limiting course.
  • Detecting specific antibodies against the polymorphic human neutrophil antigen usually confirms the diagnosis.
  • METHODS: We evaluated 120 children with a clinical suspicion of AIN, whose sera were analyzed by flow cytometry for the presence of autoantibodies using the indirect granulocyte immunofluorescence test.

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  • (PMID = 20550032.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Israel
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic
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67. Murakami Y, Suzuki J, Samejima K, Oka T: Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland. Amino Acids; 2010 Feb;38(2):591-601
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  • Ornithine decarboxylase (ODC), antizyme (AZ), and antizyme inhibitor (AIn) play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions.
  • The level of spermidine and expression of genes encoding spermidine synthase and AIn increased in a closely parallel manner with that of casein gene expression during pregnancy and lactation.
  • Immunohistochemical analysis showed the translocation of ODC and AIn between the nucleus and cytoplasm and the continuous presence of AZ in the nucleus during gland development.
  • Reduction of AIn by RNA interference inhibited expression of beta-casein gene stimulated by lactogenic hormones in HC11 cells.
  • These results suggested that AIn plays an important role in the mammary gland development by changing its expression, subcellular localization, and functional interplay with AZ.

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  • (PMID = 19997757.001).
  • [ISSN] 1438-2199
  • [Journal-full-title] Amino acids
  • [ISO-abbreviation] Amino Acids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Caseins; 0 / Ornithine Decarboxylase Inhibitors; 0 / Polyamines; 0 / Proteins; 0 / ornithine decarboxylase antizyme; 0 / ornithine decarboxylase antizyme inhibitor; EC 4.1.1.17 / Ornithine Decarboxylase
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68. Rudge JS, Holash J, Hylton D, Russell M, Jiang S, Leidich R, Papadopoulos N, Pyles EA, Torri A, Wiegand SJ, Thurston G, Stahl N, Yancopoulos GD: VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci U S A; 2007 Nov 20;104(47):18363-70
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  • [MeSH-minor] Aging / physiology. Animals. Antibodies / immunology. Biomarkers. Cell Line, Tumor. Cervical Intraepithelial Neoplasia / metabolism. Cervical Intraepithelial Neoplasia / pathology. Humans. Male. Mice. Mice, SCID. Protein Binding. Xenograft Model Antitumor Assays

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  • (PMID = 18000042.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies; 0 / Biomarkers; 0 / Vascular Endothelial Growth Factors
  • [Other-IDs] NLM/ PMC2141784
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69. Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA: The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. Int J STD AIDS; 2007 Feb;18(2):77-80
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  • [Title] The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
  • Due to the increasing incidence of anal cancer in HIV-positive men who have sex with men, and the potential to detect and treat high-grade anal dysplasia--the putative anal cancer precursor--we have introduced an anal cytology screening service.
  • Patients with abnormal anal cytology have follow-up high-resolution anoscopy (HRA) with biopsy of lesions clinically suspicious for high-grade dysplasia.
  • One hundred and sixty-four (67%) men had abnormal anal cytology, and 93 of them had follow-up HRA and anal biopsy.
  • The positive predictive value for any anal cytological abnormality to predict any degree of anal dysplasia was 95.7+/-2.1%, and for any anal cytological abnormality to predict high-grade anal dysplasia was 55.9+/-5.1%.
  • Abnormal anal cytology was highly predicative of anal dysplasia on biopsy.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma, Squamous Cell. HIV Infections / complications. Homosexuality, Male
  • [MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / epidemiology. Adult. Aged. Biopsy. Cytological Techniques. Humans. Male. Middle Aged. Predictive Value of Tests. Prevalence

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  • (PMID = 17331275.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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70. Pan S, Chen R, Reimel BA, Crispin DA, Mirzaei H, Cooke K, Coleman JF, Lane Z, Bronner MP, Goodlett DR, McIntosh MW, Traverso W, Aebersold R, Brentnall TA: Quantitative proteomics investigation of pancreatic intraepithelial neoplasia. Electrophoresis; 2009 Apr;30(7):1132-44
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  • [Title] Quantitative proteomics investigation of pancreatic intraepithelial neoplasia.
  • Pancreatic intraepithelial neoplasia (PanIN) 3 is believed to be the immediate precursor lesion of pancreatic adenocarcinoma, and would be an ideal stage to diagnose patients, when intervention and cure are possible and patients are curable.
  • All three of these proteins were overexpressed in the stroma or ductal epithelial cells of advanced PanIN lesions as well as in pancreatic cancer tissue.
  • The dysregulated proteins identified in this study may assist in the selection of candidates for future development of biomarkers for detecting early and curable pancreatic neoplasia.

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  • (PMID = 19373808.001).
  • [ISSN] 1522-2683
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / N01HV28179; United States / NCI NIH HHS / CA / 1R01CA107209; United States / NHLBI NIH HHS / HV / N0I-HV-28179; United States / NCI NIH HHS / CA / CA107209-03; United States / NCI NIH HHS / CA / R01 CA107209; United States / NCI NIH HHS / CA / R01 CA107209-03; United States / NCI NIH HHS / CA / K07 CA116296; United States / NCI NIH HHS / CA / K07CA116296
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Proteome
  • [Other-IDs] NLM/ NIHMS147339; NLM/ PMC2775073
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71. Graziottin A, Serafini A: HPV infection in women: psychosexual impact of genital warts and intraepithelial lesions. J Sex Med; 2009 Mar;6(3):633-45
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  • [Title] HPV infection in women: psychosexual impact of genital warts and intraepithelial lesions.
  • HPV is a wide family of DNA viruses, which may cause benign skin and mucosal tumors (genital, anal, or oral warts), intraepithelial neoplasias, and/or malignant cancers in different organs.
  • (ii) HPV-related genital, oral, and anal precancerous lesions on women's sexual function.
  • Search terms were HPV, GWs, intraepithelial neoplasia, cervical cancer, anal cancer, oral cancer, epidemiology, HPV risk factors, sexual dysfunctions, desire disorders, arousal disorders, dyspareunia, vulvar vestibulitis, vulvodynia, orgasmic difficulties, sexual repertoire, couple sexual problems, depression, anxiety, pap smear, screening program, therapy, and vaccines.
  • MAIN OUTCOME MEASURES: Sexual consequences of HPV infection in women, specifically GWs and intraepithelial HPV-related neoplasia.
  • However, to date, there is no conclusive evidence of a specific correlation between HPV infection and a specific female sexual disorder.
  • CONCLUSION: The evidence of psychosexual consequences of HPV-related GWs and intraepithelial lesions is limited.
  • Specific research on the sexual impact of GWs and intraepithelial HPV-related lesion in women is urgently needed.
  • [MeSH-major] Condylomata Acuminata / psychology. Epithelium / pathology. Epithelium / virology. Papillomaviridae / isolation & purification. Papillomavirus Infections / diagnosis. Papillomavirus Infections / epidemiology. Sexual Dysfunctions, Psychological / diagnosis. Sexual Dysfunctions, Psychological / epidemiology
  • [MeSH-minor] Anxiety Disorders / epidemiology. Anxiety Disorders / psychology. Depressive Disorder / epidemiology. Depressive Disorder / psychology. Dyspareunia / epidemiology. Female. Humans. Risk Factors

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  • (PMID = 19170869.001).
  • [ISSN] 1743-6109
  • [Journal-full-title] The journal of sexual medicine
  • [ISO-abbreviation] J Sex Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 74
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72. Bang HJ, Arakawa C, Takada M, Sato M, Imaizumi K: A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels. Biosci Biotechnol Biochem; 2008 Dec;72(12):3128-33
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  • C57BL/6J mice were fed an AIN-93G-based diet containing 0.2 g/kg of oxycholesterol or oxyphytosterol for 4 weeks.

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  • (PMID = 19060413.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cholesterol, Dietary; 0 / Hydroxycholesterols; 0 / Phytosterols; 0 / Triglycerides; 47IMW63S3F / 24-hydroxycholesterol; 97C5T2UQ7J / Cholesterol
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73. Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Stücker M, Altmeyer P, Swoboda J, Pfister H, Wieland U, German Competence Network HIV/AIDS: Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men. J Invest Dermatol; 2008 Aug;128(8):2078-83
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  • [Title] Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men.
  • Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated precursor lesion of anal carcinoma, is highly prevalent in HIV-infected men having sex with men (MSM).
  • This prospective follow-up study evaluated the long-term results of imiquimod treatment of AIN in 19 HIV-infected MSM.
  • Standardized follow-up examinations included high-resolution anoscopy, anal cytology/histology, HPV typing, and DNA load determination for HPV types 16, 18, 31, and 33.
  • A total of 74% (14/19) of the patients remained free of AIN at the previously treated site.
  • Five patients (26%) had recurrent high-grade AIN after a mean time of 24.6 months.
  • During follow-up, 58% of all patients (11/19) developed new anal cytological abnormalities in previously normal, untreated anal regions.
  • 55% of these new AIN lesions were high-grade lesions and most of them were located intra-anally and associated with high-risk HPV types not detectable before therapy.
  • These results demonstrate that imiquimod leads to a high rate of long-term clearance of AIN in HIV-positive men together with a prolonged decrease of high-risk HPV-DNA load.
  • However, new AIN lesions associated with previously undetected HPV types frequently occur in untreated areas.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. DNA, Viral / drug effects. HIV Infections / complications. Papillomaviridae / genetics

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  • (PMID = 18273049.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / DNA, Viral; 99011-02-6 / imiquimod
  • [Investigator] Adam A; Schewe K; Weitner L; Aratesh K; Arendt G; Bartz C; Behrens G; Beichert M; Bieniek B; Cordes C; Bochow M; Brockmeyer N; Buchholz B; Bogner JR; Buhk T; Clad A; Dannecker M; Dupke S; von Einsiedel R; Esser S; Faetkenheuer G; Fischer K; Freiwald M; Friebe-Hoffmann U; Fenske S; Funk M; Ganschow R; Gingelmaier A; Glaunsinger T; Goebel FD; Gölz J; Grosch-Wörner I; Haberl A; Hamouda O; Harrer T; Hartmann M; Hartl H; Hölscher M; Hower M; Husstedt IW; Jansen K; Jäger H; Jessen H; Jessen A; Karwat M; Klausen G; Kirchhoff F; Knechten H; Köppe S; Kreuter A; Kuhlmann B; Langer P; Lauenroth-Mai; Lehmacher W; Lehmann M; Levin C; Lübke M; Maschke M; Marcus U; Mauss S; Meyerhans A; Meyer-Olson D; ter Meulen V; Michalik C; Moll A; Mosthaf FA; Mutz A; Neuen-Jacob E; Niehues T; Oette M; Paulus U; Plettenberg A; Potthoff A; Racz P; Racz K; Rasokat H; Rausch M; Reichelt D; Reitter A; Rieke A; Rockstroh J; Salzberger B; Schafberger A; Schauer J; Schlote F; Schmidt B; Schranz D; Scholten S; Schuler C; Schwab M; Schmidt W; Schmidt R; Schwarze S; Siffert W; Skaletz-Rorowski A; Sonnenberg-Schwan U; Sopper S; Spengler U; Staszewski S; Steffan E; Stellbrink HJ; Stoll M; Goecke T; Taubert S; Telschik A; Ulmer A; Ullrich R; Uberla K; Usadel S; Vogel M; Wagner R; Walter H; Warnatz K; Wasem J; Wiesel W; Von Weizsäcker K; Wieland U; Wintergerst U; Wolf E; Wolf H; Wünsche T; Wyen Ch; Zeitz M; Zylka-Menhorn V
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74. Mirghani HM, Khair H: Comparison between visual and computerized cardiotocography in low risk pregnancy. Saudi Med J; 2005 Aug;26(8):1228-30
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  • The study was carried out at Al-Ain Medical District, United Arab Emirates, between August 2004 and December 2004.
  • [MeSH-minor] Adult. Diagnosis, Computer-Assisted. Female. Humans. Infant, Newborn. Predictive Value of Tests. Pregnancy. Pregnancy Outcome


75. Nahas SC, Nahas CS, Silva Filho EV, Levi JE, Atui FC, Marques CF: Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report. Sao Paulo Med J; 2007 Sep 6;125(5):292-4
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  • [Title] Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report.
  • CONTEXT: Highly active antiretroviral therapy (HAART) has turned human immunodeficiency virus (HIV) infection into a chronic condition, and this has led to increased incidence of anal dysplasia among HIV-positive patients.
  • Routine anal evaluation including the anal canal and perianal area is recommended for this population, especially for patients infected by oncogenic human papillomavirus (HPV) types.
  • CASE REPORT: A 54-year-old homosexual HIV-positive man presented with a six-year history of recurrent perianal and anal warts.
  • He presented some condylomatous spreading lesions occupying part of the anal canal and the perianal skin, and also a well-demarcated slightly painful perianal plaque of dimensions 1.0 x 1.0 cm.
  • Both anal canal Pap smears and biopsies guided by high-resolution anoscopy revealed high-grade squamous intraepithelial lesion.
  • Biopsies of the border of the perianal plaque also revealed high-grade squamous intraepithelial lesion.
  • HPV DNA testing of the anus detected the presence of HPV-16 type.
  • Histological analysis on the excised tissue revealed high-grade squamous intraepithelial lesion with one focus of microinvasive squamous cell cancer measuring 1 mm.
  • The patient showed pathological evidence of recurrent anal and perianal high-grade squamous intraepithelial lesions at the sixth-month follow-up and required further ablation of those lesions.
  • However no invasive squamous cell carcinoma recurrence has been detected so far.
  • [MeSH-major] Antiretroviral Therapy, Highly Active / adverse effects. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. HIV Seropositivity / drug therapy. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections / pathology
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / virology. DNA, Viral / analysis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis


76. Yu J, Ohuchida K, Nakata K, Mizumoto K, Cui L, Fujita H, Yamaguchi H, Egami T, Kitada H, Tanaka M: LIM only 4 is overexpressed in late stage pancreas cancer. Mol Cancer; 2008;7:93
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  • METHODS: We measured LMO4 mRNA levels in cultured cells, pancreatic bulk tissues and microdissected target cells (normal ductal cells; pancreatic intraepithelial neoplasia-1B [PanIN-1B] cells; PanIN-2 cells; invasive ductal carcinoma [IDC] cells; intraductal papillary-mucinous adenoma [IPMA] cells; IPM borderline [IPMB] cells; and invasive and non-invasive IPM carcinoma [IPMC]) by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR).
  • RESULTS: 9 of 14 pancreatic cancer cell lines expressed higher levels of LMO4 mRNA than did the human pancreatic ductal epithelial cell line (HPDE).

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  • (PMID = 19099607.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Homeodomain Proteins; 0 / LIM Domain Proteins; 0 / LMO4 protein, human; 0 / RNA, Messenger; 0 / Transcription Factors; EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ PMC2628350
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77. Sun GS, Tou JC, Liittschwager K, Herrera AM, Hill EL, Girten B, Reiss-Bubenheim D, Vasques M: Evaluation of the nutrient-upgraded rodent food bar for rodent spaceflight experiments. Nutrition; 2010 Nov-Dec;26(11-12):1163-9
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  • Young (age 13-14 wk) male Sprague-Dawley rats (n=16/group) were individually caged and fed a diet treatment consisting of 1) NuRFB, 2) RFB, or 3) modified AIN-93G containing 4% instead of the 7% fat for 45- or 90-d.
  • Subsequent animal feeding studies showed that NuRFB was comparable to RFB and modified AIN-93G for supporting rat growth and body weight maintenance.

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 20116210.001).
  • [ISSN] 1873-1244
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 059QF0KO0R / Water
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78. Korraa E, Madkour A, Wagieh K, Nafae A: Bronchoscopic foreign body extraction in a pulmonary medicine department: a retrospective review of egyptian experience. J Bronchology Interv Pulmonol; 2010 Jan;17(1):39-44
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  • This study aimed to retrospectively review the results of 2 years of experience with 120 patients who presented or were referred to the Pulmonary Medicine Department, Ain Shams University Hospital in Cairo, Egypt, with clinical suspicion of FB aspiration during the period between December 2006 and December 2008.

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  • (PMID = 23168658.001).
  • [ISSN] 1944-6586
  • [Journal-full-title] Journal of bronchology & interventional pulmonology
  • [ISO-abbreviation] J Bronchology Interv Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Singhal R, Shankar K, Badger TM, Ronis MJ: Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17{beta}-estradiol treatment. J Endocrinol; 2009 Jul;202(1):141-52
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  • Female Sprague-Dawley rats were fed AIN-93G diets containing casein (CAS) or SPI starting at postnatal day (PND) 30.

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  • (PMID = 19372191.001).
  • [ISSN] 1479-6805
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isoflavones; 0 / Soybean Proteins; 4TI98Z838E / Estradiol
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80. Ryad AY, Mostafa E, Salem DA, Al-Adwy ER, Margerges M: Assessment of Survival and Clinical Benefit in Malignant Pleural Mesothelioma (MPM) Patients Treated with Gemcitabine and Carboplatin. J Egypt Natl Canc Inst; 2007 Mar;19(1):61-70
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  • PATIENTS AND METHODS: This prospective phase II study was performed on 42 eligible patients with histologically or cytologically proven MPM presenting to Ain Shams University hospitals and Sohag Cancer Center between January 2002 and April 2006.

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  • (PMID = 18839036.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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81. Singhal R, Badger TM, Ronis MJ: Reduction in 7,12-dimethylbenz[a]anthracene-induced hepatic cytochrome-P450 1A1 expression following soy consumption in female rats is mediated by degradation of the aryl hydrocarbon receptor. J Nutr; 2007 Jan;137(1):19-24
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  • Female Sprague-Dawley rats were fed AIN-93G diets with (+) or without (-) SPI-bound phytochemicals or casein (CAS) protein and gavaged orally with 7,12-dimethylbenz[a]anthracene (DMBA) or sesame oil.

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  • (PMID = 17182795.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Receptors, Aryl Hydrocarbon; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; 63231-63-0 / RNA; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
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82. Sato M, Shibata K, Nomura R, Kawamoto D, Nagamine R, Imaizumi K: Linoleic acid-rich fats reduce atherosclerosis development beyond its oxidative and inflammatory stress-increasing effect in apolipoprotein E-deficient mice in comparison with saturated fatty acid-rich fats. Br J Nutr; 2005 Dec;94(6):896-901
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  • Male and female apo E-deficient mice (8 weeks old; seven to eight per group) were fed an AIN-76-based diet containing SF fat (50 g palm oil and 50 g lard/kg) or HL fat (100 g high-linoleic safflower-seed oil/kg) for 9 weeks.

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  • (PMID = 16351765.001).
  • [ISSN] 0007-1145
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Biomarkers; 0 / Ccl2 protein, mouse; 0 / Chemokine CCL2; 0 / Dietary Fats; 0 / Fatty Acids; 0 / RNA, Messenger; 0 / Thiobarbituric Acid Reactive Substances; 0 / Vasoconstrictor Agents; 27415-26-5 / 8-epi-prostaglandin F2alpha; 97C5T2UQ7J / Cholesterol; 9KJL21T0QJ / Linoleic Acid; B7IN85G1HY / Dinoprost
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83. Newsom-Davis T, Bower M: HIV-associated anal cancer. F1000 Med Rep; 2010;2:85
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  • [Title] HIV-associated anal cancer.
  • HIV-associated anal carcinoma, a non-AIDS-defining cancer, is a human papillomavirus-associated malignancy with a spectrum of preinvasive changes.
  • The standardized incidence ratio for anal cancer in patients with HIV/AIDS is 20-50.
  • Algorithms for anal cancer screening include anal cytology followed by high-resolution anoscopy for those with abnormal findings.
  • Outpatient topical treatments for anal intraepithelial neoplasia include infrared coagulation therapy, trichloroacetic acid, and imiquimod.
  • The development of cost-effective national screening programs for HIV-associated anal cancer remains a challenge.

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  • (PMID = 21283597.001).
  • [ISSN] 1757-5931
  • [Journal-full-title] F1000 medicine reports
  • [ISO-abbreviation] F1000 Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3026623
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84. Rossini M, Cheunsuchon B, Donnert E, Ma LJ, Thomas JW, Neilson EG, Fogo AB: Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease. Kidney Int; 2005 Dec;68(6):2621-8
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  • We examined the expression of FGF-1 and FGF receptor (FGFR-1) to determine if renal diseases with varying etiologies of inflammation, including lupus nephritis (LN), acute interstitial nephritis (AIN) and acute rejection superimposed on chronic allograft nephropathy (CAN), showed varying patterns of expression.
  • We also examined the expression of fibroblast-specific protein-1 (FSP-1), which has been linked to epithelial-mesenchymal transition (EMT) and fibrosis, to determine whether it was linked to potential profibrotic and inflammatory FGF-1 mechanisms.
  • METHODS: Proliferative LN (PLN) (N= 12), nonproliferative lupus nephritis (NPLN) (N= 5), AIN (N= 6), CAN (N= 4), and normal kidneys (N= 3) were studied.
  • RESULTS: In normal kidneys, FGF-1 was expressed in mesangial cells (0.67 +/- 0.58), glomerular endothelial (0.67 +/- 0.58), visceral, and parietal epithelial cells (1.67 +/- 0.58).
  • Expression of FGF-1 was increased over normal in glomerular parenchymal cells only in CAN in podocytes (2.30 +/- 0.58 vs. 3.00 +/- 0.00) (P < 0.05) and parietal epithelial cells (1.67 +/- 0.58 vs. 2.25 +/- 0.50) (P < 0.05).

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  • (PMID = 16316338.001).
  • [ISSN] 0085-2538
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / FSP1 protein, human; 104781-85-3 / Fibroblast Growth Factor 1; EC 2.7.10.1 / FGFR1 protein, human; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 1
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85. Termini L, Boccardo E, Esteves GH, Hirata R Jr, Martins WK, Colo AE, Neves EJ, Villa LL, Reis LF: Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment. BMC Med Genomics; 2008;1:29
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  • HPV-16, -18, -31, and -45) is the main risk factor for development of cervical intraepithelial neoplasia and cervical cancer.
  • Tumor necrosis factor (TNF) is a key mediator of epithelial cell inflammatory response and exerts a potent cytostatic effect on normal or HPV16, but not on HPV18 immortalized keratinocytes.

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  • (PMID = 18588690.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2459201
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86. Saito M, Kiyose C, Higuchi T, Uchida N, Suzuki H: Effect of collagen hydrolysates from salmon and trout skins on the lipid profile in rats. J Agric Food Chem; 2009 Nov 11;57(21):10477-82
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  • To test the effect of fish collagen peptides on continuous administration, rats were fed an AIN-93G purified diet containing 0.17% fish collagen peptide.

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  • (PMID = 19831419.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fish Proteins; 0 / Lipids; 0 / Peptides; 0 / Triglycerides; 9007-34-5 / Collagen
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87. Bendjoudi Z, Taleb F, Abdelmalek F, Addou A: Healthcare waste management in Algeria and Mostaganem department. Waste Manag; 2009 Apr;29(4):1383-7
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  • A data study was made on 95 hospitals across the country, and the three health sectors of Mostaganem department (Mostaganem, Ain Tédles, and Sidi Ali) were surveyed.

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  • (PMID = 19091540.001).
  • [ISSN] 0956-053X
  • [Journal-full-title] Waste management (New York, N.Y.)
  • [ISO-abbreviation] Waste Manag
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Medical Waste Disposal
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88. Park JA, Ha SK, Kang TH, Oh MS, Cho MH, Lee SY, Park JH, Kim SY: Protective effect of apigenin on ovariectomy-induced bone loss in rats. Life Sci; 2008 Jun 20;82(25-26):1217-23
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  • Three-month-old female Sprague-Dawley rats were either sham-operated or ovariectomized and fed AIN-93G diet for 7 weeks to induce bone loss.

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  • (PMID = 18508086.001).
  • [ISSN] 0024-3205
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protective Agents; 104982-03-8 / Osteocalcin; 4TI98Z838E / Estradiol; 7V515PI7F6 / Apigenin; EC 3.1.3.1 / Alkaline Phosphatase
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89. González E, Gutiérrez E, Galeano C, Chevia C, de Sequera P, Bernis C, Parra EG, Delgado R, Sanz M, Ortiz M, Goicoechea M, Quereda C, Olea T, Bouarich H, Hernández Y, Segovia B, Praga M, Grupo Madrileño De Nefritis Intersticiales: Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int; 2008 Apr;73(8):940-6
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  • The role of steroid treatment in drug-induced acute interstitial nephritis (DI-AIN) is controversial.
  • We performed a multicenter retrospective study to determine the influence of steroids in 61 patients with biopsy-proven DI-AIN, 52 of whom were treated with steroids.
  • Our study shows that steroids should be started promptly after diagnosis of DI-AIN to avoid subsequent interstitial fibrosis and an incomplete recovery of renal function.


90. McIntosh GH, Royle PJ, Lesno S, Scherer BL: Selenised casein protects against AOM-induced colon tumors in Sprague Dawley rats. Nutr Cancer; 2006;54(2):209-15
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  • This casein was included in a semi-purified AIN rodent diet so as to provide 1 ppm Se and 25% protein and was compared with AIN diets containing no added Se (control, 0.05 ppm), 1 ppm and 4 ppm Se as selenised yeast (Sel-Plex) Their influence on colon tumor expression was examined in rats induced with azoxymethane, the diets being introduced post-induction.

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  • (PMID = 16898865.001).
  • [ISSN] 0163-5581
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Caseins; H6241UJ22B / Selenium; MO0N1J0SEN / Azoxymethane
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91. Tadros AM, Eid HO, Abu-Zidan FM: Epidemiology of foot injury in a high-income developing country. Injury; 2010 Feb;41(2):137-40
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  • PATIENTS AND METHODS: All patients admitted to Al-Ain Hospital with foot injury between March 2003 and March 2006 were identified from a prospectively collected Trauma Registry.

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  • [Copyright] Copyright 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19570532.001).
  • [ISSN] 1879-0267
  • [Journal-full-title] Injury
  • [ISO-abbreviation] Injury
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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92. Mostafa BE, El Fiky L, El Sharnoubi M: Non-intubation traumatic laryngotracheal stenosis: management policies and results. Eur Arch Otorhinolaryngol; 2006 Jul;263(7):632-6
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  • We present our experience at Ain-Shams University Hospitals on 15 patients followed-up for 7 years.

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  • (PMID = 16633824.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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93. Rizk DE, El-Zubeir MA, Al-Dhaheri AM, Al-Mansouri FR, Al-Jenaibi HS: Determinants of women's choice of their obstetrician and gynecologist provider in the UAE. Acta Obstet Gynecol Scand; 2005 Jan;84(1):48-53
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  • METHODS: Consecutive sample of 508 patients attending the obstetric and gynecologic services of AL-Ain Hospital; AL-Ain; United Arab Emirates during 4 months was recruited.


94. Kim HA, Jeong KS, Park DH, Lee JA, Jeong WI, Kim YK: Heavy water labeling method for measuring the effect of genistein on mammary gland carcinogenesis. Mol Cell Biochem; 2007 Jul;301(1-2):201-8
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  • Female Sprague-Dawley rats were fed estrogen-free AIN-93G diet starting 1 week before breeding and continuing through pregnancy and lactation.
  • Female pups were assigned to the following groups on postnatal day 16 and fed AIN-93G diet: vehicle (dimethylsulfoxide) (DMSO), genistein, and estradiol benzoate (EB).
  • Mammary epithelial cell proliferation was measured by enrichment (EM1) of dA from rats.
  • Bromodeoxyuridine (BrdU) immunostaining of mammary tissue revealed that genistein reduced proliferation of the mammary epithelial, and the number of cells stained positive for BrdU both in DMBA-treated groups and DMBA non-treated groups.
  • The exposure to genistein in the prepubertal period inhibited mammary epithelial cell proliferation.
  • [MeSH-minor] 9,10-Dimethyl-1,2-benzanthracene / toxicity. Animals. Body Water / chemistry. Carcinogens / toxicity. Diet. Epithelial Cells / cytology. Epithelial Cells / metabolism. Female. Humans. Male. Pregnancy. Rats. Rats, Sprague-Dawley

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  • (PMID = 17318409.001).
  • [ISSN] 0300-8177
  • [Journal-full-title] Molecular and cellular biochemistry
  • [ISO-abbreviation] Mol. Cell. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Carcinogens; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; DH2M523P0H / Genistein; J65BV539M3 / Deuterium Oxide
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95. Zhang J, Martins CR, Fansler ZB, Roemer KL, Kincaid EA, Gustafson KS, Heitjan DF, Clark DP: DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. Clin Cancer Res; 2005 Sep 15;11(18):6544-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma.
  • PURPOSE: Anal intraepithelial neoplasia is associated with human papillomavirus infection and may progress to invasive squamous cell carcinoma (SCC), which is increasing in immunocompromised patients.
  • We hypothesize that anal intraepithelial neoplasia is associated with abnormal DNA methylation and that detection of these events may be used to improve screening programs.
  • EXPERIMENTAL DESIGN: Seventy-six patients were identified who underwent anal cytology screening and subsequent biopsy at our institution between 1999 and 2004.
  • The specimens from these patients included 184 anal biopsies [normal, n = 57; low-grade squamous intraepithelial lesion (LSIL), n = 74; high-grade squamous intraepithelial lesion (HSIL), n = 41; and invasive SCC, n = 12] and 37 residual liquid-based anal cytology specimens (normal, n = 11; LSIL, n = 12; HSIL, n = 14).
  • CONCLUSIONS: Aberrant DNA methylation is a frequent event in anal HSIL and SCC.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. DNA Methylation

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  • (PMID = 16166431.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / CADM1 protein, human; 0 / Carrier Proteins; 0 / Cell Adhesion Molecules; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / HIC1 protein, human; 0 / Immunoglobulins; 0 / Kruppel-Like Transcription Factors; 0 / MLH1 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / RASSF1 protein, human; 0 / Receptors, Retinoic Acid; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Proteins; 0 / retinoic acid receptor beta; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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96. Lala G, Malik M, Zhao C, He J, Kwon Y, Giusti MM, Magnuson BA: Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. Nutr Cancer; 2006;54(1):84-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fischer 344 male rats were fed the AIN-93 diet (control) or AIN-93 diet supplemented with AREs for 14 wk.

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  • (PMID = 16800776.001).
  • [ISSN] 0163-5581
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthocyanins; 0 / Bile Acids and Salts; 0 / Biomarkers; 0 / Plant Extracts; 0 / RNA, Messenger; 059QF0KO0R / Water; 5Z93L87A1R / Guanine; 6957-76-2 / 8-oxo-7,8-dihydrodeoxyguanine; EC 1.14.99.1 / Cyclooxygenase 2
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97. Perazella MA, Markowitz GS: Drug-induced acute interstitial nephritis. Nat Rev Nephrol; 2010 Aug;6(8):461-70
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  • Acute interstitial nephritis (AIN) is a common cause of acute kidney injury.
  • Many etiologies of AIN have been recognized--including allergic/drug-induced, infectious, autoimmune/systemic, and idiopathic forms of disease.
  • The most common etiology of AIN is drug-induced disease, which is thought to underlie 60-70% of cases.
  • Multiple agents from many different classes of drugs can cause AIN, and the clinical presentation and laboratory findings vary according to the class of drug involved.
  • AIN is characterized by interstitial inflammation, tubulitis, edema, and in some cases, eventual interstitial fibrosis.
  • A definitive diagnosis of AIN can be established only by kidney biopsy.
  • The mainstay of therapy for drug-induced AIN is timely discontinuation of the causative agent.
  • Although the benefits of corticosteroid therapy remain unproven, they do appear to have a positive effect in some patients with drug-induced AIN, especially when treatment is initiated early in the course of the disease.
  • In general, the prognosis for drug-induced AIN is good, and at least partial recovery of kidney function is normally observed.
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans

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  • (PMID = 20517290.001).
  • [ISSN] 1759-507X
  • [Journal-full-title] Nature reviews. Nephrology
  • [ISO-abbreviation] Nat Rev Nephrol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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98. Tarazona Santabalbina FJ, Belenguer Varea A, Doménech Pascual JR, Gac Espínola H, Cuesta Peredo D, Medina Domínguez L, Salvador Pérez MI, Avellana Zaragoza JA: [Validation of MNA scale score as a nutritional risk factor in institutionalized geriatric patients with moderate and severe cognitive impairment]. Nutr Hosp; 2009 Nov-Dec;24(6):724-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Validez de la escala MNA como factor de riesgo nutricional en pacientes geriátricos institucionalizados con deterioro cognitivo moderado y severo.
  • The sensitivity, specificity, and positive predictive value of MNA scale were studied regarding the parameters on malnutrition of the American Institute of Nutrition (AIN).

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  • (PMID = 20049377.001).
  • [ISSN] 0212-1611
  • [Journal-full-title] Nutrición hospitalaria
  • [ISO-abbreviation] Nutr Hosp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Validation Studies
  • [Publication-country] Spain
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99. Al-Maskari F, El-Sadig M: Prevalence of diabetic retinopathy in the United Arab Emirates: a cross-sectional survey. BMC Ophthalmol; 2007;7:11
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  • The aim of this study was to estimate the prevalence and determinants of retinopathy among diabetics in Al-Ain city, United Arab Emirates (UAE).
  • METHODS: The study was part of a general cross-sectional survey carried out to assess the prevalence of diabetes (DM) complications including retinopathy among known diabetic patients in Al-Ain District, UAE.

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  • (PMID = 17572909.001).
  • [ISSN] 1471-2415
  • [Journal-full-title] BMC ophthalmology
  • [ISO-abbreviation] BMC Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1913498
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100. Patel HS, Silver AR, Levine T, Williams G, Northover JM: Human papillomavirus infection and anal dysplasia in renal transplant recipients. Br J Surg; 2010 Nov;97(11):1716-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus infection and anal dysplasia in renal transplant recipients.
  • BACKGROUND: Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including anal squamous cell carcinoma.
  • The demographics of anal HPV and associated risk factors were investigated in this population.
  • METHODS: Anal cytology and polymerase chain reaction were used to assess anal HPV disease in a cohort of transplant recipients at the Royal London Hospital.
  • Risk factors associated with increased immunosuppression and HPV exposure were collated to determine any association with anal disease.
  • RESULTS: Anal dysplasia was associated with anal oncogenic HPV infection (P < 0.001), duration of immunosuppression (P = 0.050), previous genital warts (P = 0.018) and receptive anal intercourse (P = 0.013).
  • CONCLUSION: Anal dysplasia was related to immunosuppression and patient factors in this cohort.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / etiology. Carcinoma, Squamous Cell / etiology. Immunosuppression / adverse effects. Kidney Transplantation. Papillomavirus Infections / complications

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  • [Copyright] Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 20730855.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 9007-49-2 / DNA
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