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1
anal carcinoma 2005:2010[pubdate] *count=100
2179 results
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'
anal carcinoma
' expands to
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Concept C0279637: anal cancer nos;
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Concept C0349534: anal margin carcinoma;
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Items 1 to 100 of about 2179
1.
Moore JS, Cataldo PA, Osler T, Hyman NH:
Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses.
Dis Colon Rectum
; 2008 Jul;51(7):1026-30; discussion 1030-1
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[MeSH-major]
Adenoma / surgery. Carcinoid Tumor / surgery.
Carcinoma
in Situ / surgery. Colonic Polyps / surgery. Colonoscopy / methods. Microsurgery / methods. Rectal Neoplasms / surgery
[MeSH-minor]
Aged.
Anal
Canal.
Diagnosis
, Differential. Female. Follow-Up Studies. Humans. Male. Neoplasm Recurrence, Local. Retrospective Studies. Treatment Outcome
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.
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.
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consumer health - Colonoscopy
.
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(PMID = 18481147.001).
[ISSN]
1530-0358
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
2.
Samuel S, Twizere JC, Bernstein LR:
YB-1 represses AP1-dependent gene transactivation and interacts with an AP-1 DNA sequence.
Biochem J
; 2005 Jun 15;388(Pt 3):921-8
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Involvement of the AP-1 (activator protein-1) transcription factor has been demonstrated previously in the regulation
of cell
proliferation and
cell
-cycle progression, in the control
of cell
migration, invasion and metastasis, and in signal transduction, stress responsiveness, DNA replication and DNA repair.
In the present study, we report that overexpression of a transfected gene encoding YB-1 in human HeLa cervical
carcinoma
cells significantly represses the transactivation of a minimal AP-1 reporter construct in response to the tumour promoter PMA.
To identify new nuclear proteins that bind specifically to the AP-1 DNA-binding site, we devised a DNA-affinity-chromatography-based assay termed NAPSTER (nucleotide-affinity preincubation specificity test of recognition) and discovered a 49 kDa protein from human
cancer
cells that binds in a sequence-specific manner to the AP-1 DNA sequence.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
ORBi (University of Liege).
Free full Text at ORBi
.
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[Cites]
Exp Cell Res. 1999 Nov 25;253(1):180-5
[
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]
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[ISSN]
1470-8728
[Journal-full-title]
The Biochemical journal
[ISO-abbreviation]
Biochem. J.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA73783; United States / NIEHS NIH HHS / ES / 5 P30 ES09106-03; United States / NCI NIH HHS / CA / R29 CA073783; United States / NIEHS NIH HHS / ES / P30 ES009106; United States / NIEHS NIH HHS / ES / P030ES09106
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Protein Subunits; 0 / RNA, Messenger; 0 / Transcription Factor AP-1; 0 / Y-Box-Binding Protein 1; 0 / YBX1 protein, human; 9007-49-2 / DNA; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.65 / MMP12 protein, human; EC 3.4.24.65 / Matrix Metalloproteinase 12
[Other-IDs]
NLM/ PMC1183473
3.
Palefsky J:
Human papillomavirus and anal neoplasia.
Curr HIV/AIDS Rep
; 2008 May;5(2):78-85
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[Title]
Human papillomavirus and
anal
neoplasia.
Anal
cancer
is a rare disease in the general population, but the incidence of
anal
cancer
is higher in certain at-risk groups, such as men who have sex with men (MSM), and immunosuppressed individuals, including those with HIV infection.
Among HIV-positive MSM, the incidence of
anal
cancer
may be as high as 10 times greater than current rates of cervical
cancer
in the general population of women.
Anal
cancer
is associated with human papillomavirus (HPV) infection and may be preceded by high-grade
anal
intraepithelial neoplasia (HGAIN).
HGAIN and
anal
HPV infection are both highly prevalent in groups at risk for
anal
cancer
.
Current issues include determining the effect of antiretroviral therapy on the natural history of HGAIN and the incidence of
anal
cancer
, optimizing diagnostic and therapeutic approaches to HGAIN, and determining the potential for prophylactic HPV vaccines to prevent
anal
HPV infection and
anal
cancer
in at-risk groups.
[MeSH-major]
Anus
Neoplasms.
Carcinoma
in Situ. Papillomavirus Infections
[MeSH-minor]
Anus
Diseases / epidemiology.
Anus
Diseases / virology. Female. HIV Infections / complications. Homosexuality, Male. Humans. Male. Papillomaviridae / isolation & purification
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MMWR Recomm Rep. 2007 Mar 23;56(RR-2):1-24
[
17380109.001
]
(PMID = 18510893.001).
[ISSN]
1548-3568
[Journal-full-title]
Current HIV/AIDS reports
[ISO-abbreviation]
Curr HIV/AIDS Rep
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
United States
[Number-of-references]
57
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4.
Friederich P, van Heumen BW, Nagtegaal ID, Berkhout M, van Krieken JH, Peters WH, Nagengast FM:
Increased epithelial cell proliferation in the ileal pouch mucosa of patients with familial adenomatous polyposis.
Virchows Arch
; 2007 Sep;451(3):659-67
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[Title]
Increased epithelial
cell
proliferation in the ileal pouch mucosa of patients with familial adenomatous polyposis.
To eliminate the risk of colorectal
cancer
in patients with familial adenomatous polyposis (FAP), reconstructive proctocolectomy is performed.
Although most colonic mucosa is resected during the ileal pouch
anal
anastomosis, adenomas and carcinomas may develop in the pouch.
This may be caused by altered
cell
kinetics due to intraluminal changes in the pouch.
Cell
proliferation was also assessed by a modified sign test.
However,
cell
proliferation was significantly higher in the mucosa of the pouch vs afferent ileal loop, both by using the quantitative (68.3% vs 61.6%, p = 0.001) and semiquantitative methods (p < 0.05).
The higher
cell
proliferation in the pouch as compared to the afferent ileal loop may contribute to the increased risk for adenomas and carcinomas in the pouch of patients with FAP and emphasizes the need for regular endoscopic surveillance.
[MeSH-major]
Adenomatous Polyposis Coli / pathology.
Cell
Division. Colonic Pouches / pathology. Epithelial Cells / pathology
[MeSH-minor]
Adenoma / pathology. Adolescent. Adult. Aged. Antibodies, Monoclonal. Apoptosis.
Carcinoma
/ pathology. Colorectal Neoplasms / pathology. Colorectal Neoplasms / prevention & control. Female. Humans. Ileum / pathology. Immunohistochemistry. Intestinal Mucosa / pathology. Male. Middle Aged. Proctocolectomy, Restorative
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Gut. 1996 Apr;38(4):549-53
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]
(PMID = 17611772.001).
[ISSN]
0945-6317
[Journal-full-title]
Virchows Archiv : an international journal of pathology
[ISO-abbreviation]
Virchows Arch.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antibodies, Monoclonal
[Other-IDs]
NLM/ PMC2039779
5.
Li AH, Phanuphak N, Sahasrabuddhe VV, Chaithongwongwatthana S, Vermund SH, Jenkins CA, Shepherd BE, Teeratakulpisarn N, van der Lugt J, Avihingsanon A, Ruxrungtham K, Shikuma C, Phanuphak P, Ananworanich J:
Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand.
Sex Transm Infect
; 2009 Dec;85(7):503-7
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[Title]
Anal
squamous
intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand.
OBJECTIVES: To evaluate the prevalence and risk factors of
anal
squamous
intraepithelial lesions (ASIL), the putative
anal
cancer
precursor, in Asian HIV positive and HIV negative men who have sex with men (MSM).
METHODS: Men who underwent
anal
Pap smear reported clinical, sociodemographic and behavioural information collected through questionnaire and interview between January 2007 and April 2008.
Overall, 27% had abnormal
anal
cytology: 13.2% had atypical
squamous
cells of undetermined significance (ASC-US), 11.5% had low-grade
squamous
intraepithelial lesion (LSIL) and 2.3% had high-grade
squamous
intraepithelial lesion (HSIL).
Anal
condyloma was detected in 22% of HIV positive and 16.1% (9/56) of HIV negative MSM (p = 0.5).
In HIV positive MSM,
anal
condyloma (OR 3.42, 95% CI 1.29 to 9.04; p = 0.01) was a significant risk factor for ASIL.
Highly active antiretroviral therapy use and CD4+ T
cell
count were not associated with ASIL.
Thus, as greater numbers of HIV positive MSM live longer due to increasing access to HAART worldwide, effective strategies to screen and manage
anal
precancerous lesions are needed.
[MeSH-major]
Anus
Neoplasms / epidemiology.
Carcinoma
in Situ / epidemiology.
Carcinoma
,
Squamous Cell
/ epidemiology. HIV Seronegativity / physiology. HIV Seropositivity / epidemiology. Homosexuality, Male / statistics & numerical data
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.
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.
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.
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.
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Semin Oncol. 2000 Aug;27(4):390-401
[
10950365.001
]
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Int J STD AIDS. 2008 Aug;19(8):529-32
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]
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]
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Cancer. 2004 Jul 15;101(2):281-8
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]
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J Acquir Immune Defic Syndr. 2001 Dec 15;28(5):422-8
[
11744829.001
]
(PMID = 19525263.001).
[ISSN]
1472-3263
[Journal-full-title]
Sexually transmitted infections
[ISO-abbreviation]
Sex Transm Infect
[Language]
eng
[Grant]
United States / NIAID NIH HHS / AI / P30 AI050410; United States / NCRR NIH HHS / RR / TL1 RR024978
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ NIHMS527353; NLM/ PMC3875384
6.
Papaconstantinou HT, Lee AJ, Simmang CL, Ashfaq R, Gokaslan ST, Sokol S, Huber PJ Jr, Gregorcyk SG:
Screening methods for high-grade dysplasia in patients with anal condyloma.
J Surg Res
; 2005 Jul 1;127(1):8-13
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[Title]
Screening methods for high-grade dysplasia in patients with
anal
condyloma.
HPV infection can cause
anal
condylomas and is a risk factor for dysplasia.
High-grade dysplasia may progress to
squamous cell
carcinoma
.
The purpose of this study is to determine whether
anal
cytology, morphological characteristics, and/or the presence of high-risk oncogenic HPV-types are effective noninvasive methods to detect high-risk
anal
condylomas.
PATIENTS AND METHODS: From November 2003 to June 2004, all patients with
anal
condyloma were prospectively evaluated for
anal
cytology, high-risk oncogenic HPV-types, and tissue biopsies.
RESULTS: Forty-seven patients with
anal
condyloma were studied; 43 (91.5%) were men, and the mean age was 39 +/- 11 years.
CONCLUSION:
Anal
cytology alone is not accurate for detecting HRL in patients with
anal
condylomas.
Combining oncogenic HPV-testing with cytology is more sensitive in detecting HRL in patients with
anal
condyloma, and therefore, a more effective screening tool.
[MeSH-major]
Anal
Canal / pathology.
Anus
Diseases / pathology.
Anus
Neoplasms / pathology. Condylomata Acuminata / pathology. Papillomaviridae. Papillomavirus Infections / pathology. Tumor Virus Infections / pathology
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.
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.
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(PMID = 15964301.001).
[ISSN]
0022-4804
[Journal-full-title]
The Journal of surgical research
[ISO-abbreviation]
J. Surg. Res.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
7.
Kirillov V, Akimova L:
Regression analysis of the initial karyometric data on tumor cells in ductal carcinoma and fibroadenoma of the mammary gland.
Anal Quant Cytol Histol
; 2010 Apr;32(2):102-5
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[Title]
Regression analysis of the initial karyometric data on tumor cells in ductal
carcinoma
and fibroadenoma of the mammary gland.
OBJECTIVE: To reveal the differences in the parameters of the second order regression curve with a cluster of experimental points on scattergrams showing the dependence of the perimeter on the area of tumor
cell
nuclei between ductal
carcinoma
and fibroadenoma of the mammary gland.
STUDY DESIGN: Punctate smears taken from patients with ductal
carcinoma
and fibroadenoma of the mammary gland with coincident histologic and cytologic conclusion were studied and selected.
RESULTS: It has been shown that the cluster of experimental points on scattergrams showing the dependence of the perimeter on the area of tumor
cell
nuclei can be well described by a second order regression curve, which is a parabola.
The differences in parabola parameters (coefficients of the parabola equation) characterizing the population of tumor cells in ductal
carcinoma
and fibroadenoma of the mammary gland were revealed.
CONCLUSION: Parameters of the regression curve to a cluster of experimental points on scattergrams showing the dependence of the perimeter on the area of tumor
cell
nuclei can be used as an additional diagnostic criterion for breast
cancer
.
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(PMID = 20701078.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
8.
Kouloulias V, Plataniotis G, Kouvaris J, Dardoufas C, Gennatas C, Uzunoglu N, Papavasiliou C, Vlahos L:
Chemoradiotherapy combined with intracavitary hyperthermia for anal cancer: feasibility and long-term results from a phase II randomized trial.
Am J Clin Oncol
; 2005 Feb;28(1):91-9
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[Title]
Chemoradiotherapy combined with intracavitary hyperthermia for
anal
cancer
: feasibility and long-term results from a phase II randomized trial.
PURPOSE: The purpose of this study was to investigate in a randomized way the clinical benefit of addition of intracavitary hyperthermia (ICHT) to a conventional chemoradiotherapy schedule in patients with T2-T3N0M0
anal
cancer
.
A microwave applicator operating at 433 MHz inserted into the
anal
-rectal cavity was used for ICHT.
CONCLUSION: The addition of ICHT to the chemoradiotherapy schedule of
anal
cancer
seems to offer a new effective and safe therapeutic modality.
[MeSH-major]
Anus
Neoplasms / therapy. Diathermy
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MITOMYCIN C
.
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.
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(PMID = 15685041.001).
[ISSN]
1537-453X
[Journal-full-title]
American journal of clinical oncology
[ISO-abbreviation]
Am. J. Clin. Oncol.
[Language]
eng
[Publication-type]
Clinical Trial; Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
[Publication-country]
United States
[Chemical-registry-number]
50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
9.
Cai L, Threadgill MD, Wang Y, Li M:
Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells.
Pathol Oncol Res
; 2009 Sep;15(3):323-8
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[Title]
Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon
carcinoma
CT26 cells.
MTT assays and flow cytometry were used to determine the proliferation and
cell
cycle distribution, respectively, of the cells.
These results suggest that PARP inhibition reduced the proliferation of CT26 cells in vitro and influences
the cell
cycle.
[MeSH-major]
Cell
Proliferation / drug effects. Colonic Neoplasms / enzymology. Enzyme Inhibitors / pharmacology. NF-kappa B / drug effects. Poly(ADP-ribose) Polymerases / metabolism
[MeSH-minor]
Animals. Blotting, Western.
Cell
Cycle.
Cell
Line, Tumor.
Cell
Separation. Electrophoretic Mobility Shift Assay. Flow Cytometry. Isoquinolines / pharmacology. Mice. Poly (ADP-Ribose) Polymerase-1
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15112579.001
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12421493.001
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Biochem Pharmacol. 2002 Jan 15;63(2):293-304
[
11841805.001
]
(PMID = 18989759.001).
[ISSN]
1532-2807
[Journal-full-title]
Pathology oncology research : POR
[ISO-abbreviation]
Pathol. Oncol. Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / 5-aminoisoquinolinone; 0 / Enzyme Inhibitors; 0 / Isoquinolines; 0 / NF-kappa B; EC 2.4.2.30 / Parp1 protein, mouse; EC 2.4.2.30 / Poly (ADP-Ribose) Polymerase-1; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases
10.
Roach SC, Hulse PA, Moulding FJ, Wilson R, Carrington BM:
Magnetic resonance imaging of anal cancer.
Clin Radiol
; 2005 Oct;60(10):1111-9
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[Title]
Magnetic resonance imaging of
anal
cancer
.
AIM: The purpose of this study was to evaluate the magnetic resonance imaging (MRI) appearances of primary and recurrent
anal carcinoma
, and to demonstrate the commonest patterns of local and distant disease spread.
METHODS: A retrospective review was performed of 27 cases of biopsy-proven
anal carcinoma
, where MRI was used for primary staging (9 patients) or suspected recurrence (18 patients).
The size, extent and signal characteristics of the
anal
tumour were documented.
Lymph node metastases were of similar signal intensity to the
anal
cancer
.
[MeSH-major]
Anus
Neoplasms / pathology.
Carcinoma
,
Squamous Cell
/ pathology. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging / methods. Neoplasm Recurrence, Local / pathology
Genetic Alliance.
consumer health - Anal Cancer
.
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.
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consumer health - MRI Scans
.
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(PMID = 16179172.001).
[ISSN]
0009-9260
[Journal-full-title]
Clinical radiology
[ISO-abbreviation]
Clin Radiol
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
England
11.
Health Quality Ontario:
Anal dysplasia screening: an evidence-based analysis.
Ont Health Technol Assess Ser
; 2007;7(4):1-43
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[Title]
Anal
dysplasia screening: an evidence-based analysis.
OBJECTIVE: This review considered the role of the
anal
Pap test as a screening test for
anal
dysplasia in patients at high risk of
anal
SCC.
CLINICAL NEED: TARGET POPULATION AND CONDITION
Anal
cancer
, like cervical
cancer
, is a member of a broader group of anogenital
cancers
known to be associated with sexually transmitted viral HPV infection.
Sexual practices involving receptive
anal
intercourse lead to significantly elevated risk for
anal
dysplasia and
cancer
, particularly in those with immune dysfunctions.
Anal
cancer
is rare.
It is the least common of the lower gastrointestinal
cancers
, representing about 4% of them, in contrast to colorectal
cancers
, which remain the third most commonly diagnosed malignancy.
Certain segments of the population, however, such as HIV-positive men and women, other chronic immune-suppressed patients (e.g., after a transplant), injection drug users, and women with genital dysplasia /
cancer
, have a high susceptibility to
anal
cancer
.
Those with the highest identified risk for
anal
cancer
are HIV-positive homosexual and bisexual men, at a rate of 70 per 100,000 men.
The risk for
anal
cancer
is reported to be increasing dramatically in HIV-positive males and females, particularly since the introduction of highly active antiretroviral therapy in the mid-1990s.
HEALTH TECHNOLOGY DESCRIPTION:
Anal
Pap test screening involves the blind insertion of a swab into the
anal
canal and fixing cells either on a slide or in fluid for cytological examination.
Anal
cytology classified by the standardized Bethesda System is the same classification used for cervical cytology.
It has 4 categories: normal, atypical
squamous
cells of uncertain significance,
or squamous
intraepithelial lesions which are further classified into low- or high-grade lesions.
Unlike cervical
cancer
, there are no universally accepted guidelines or standards of care for
anal
dysplasia.
The New York State Department of Health AIDS Institute has recently recommended (March 2007) annual
anal
pap testing in high-risk groups.
In Ontario, reimbursement exists only for Pap tests for cervical
cancer
screening.
That is, there is no reimbursement for
anal
Pap testing in men or women, and HPV screening tests for cervical or
anal
cancer
are also not reimbursed.
Assessments of current practices were obtained through consultations with various agencies and individuals including the Ministry of Health and Long-Term Care AIDS Bureau; Public Health Infectious Diseases Branch, Ministry of Health and Long-Term Care;
Cancer
Care Ontario; HIV/AIDS researchers; pathology experts; and HIV/AIDS clinical program directors.
FINDINGS: No direct evidence was found for the existence of controlled studies evaluating the effectiveness of
anal
Pap test screening programs for impact on
anal
cancer
morbidity or mortality.
In addition, no studies were found on the use of HPV DNA testing in the screening or diagnostic setting for
anal
dysplasia.
The reported prevalence of HPV infection in high-risk groups, particularly HIV-positive males, however, was sufficiently high to preclude any utility of HPV testing as an adjunct to
anal
Pap testing.
Nine reports involving studies in the United States, United Kingdom, and Canada were identified that evaluated the performance characteristics of
anal
Pap test screening for
anal
dysplasia.
Estimates of
anal
Pap test sensitivity and specificity were highly variable, and depended on the varying prevalence of cytology abnormality and differential thresholds for abnormality for both cytology and histopathology.
CONCLUSIONS: No direct evidence exists to support the effectiveness of an
anal
Pap test screening program to reduce
anal
cancer
mortality or morbidity.
There are, however, strong parallels with cervical pap testing for cervical
cancer
.
Sexually transmitted HPV viral infection is currently the acknowledged common causative agent for both
anal
and cervical
cancer
.
Anal
cancer
rates in high-risk populations are approaching those of cervical
cancer
before the implementation of Pap testing.
The
anal
Pap test, although it has been mainly evaluated only in HIV-positive males, has similar operating characteristics of sensitivity and specificity as the cervical Pap test.
In general, the treatment options for precancer dysplasia in the cervix and
the anus
are similar, but treatment involving a definitive surgical resection in
the anus
is more limited because of the higher risk of complications.
A range of ablative therapies has been applied for
anal
dysplasia, but evidence on treatment effectiveness, tolerability and durability, particularly in the HIV-positive patient, is limited.
NCI CPTC Antibody Characterization Program.
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[ISSN]
1915-7398
[Journal-full-title]
Ontario health technology assessment series
[ISO-abbreviation]
Ont Health Technol Assess Ser
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Canada
[Other-IDs]
NLM/ PMC3377578
12.
Bartusik D, Tomanek B, Lattová E, Perreault H, Fallone G:
Combined treatment of human MCF-7 breast carcinoma with antibody, cationic lipid and hyaluronic acid using ex vivo assays.
J Pharm Biomed Anal
; 2010 Jan 5;51(1):192-201
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[Title]
Combined treatment of human MCF-7 breast
carcinoma
with antibody, cationic lipid and hyaluronic acid using ex vivo assays.
The effective targeting of malignant
cell
surface antigens is essential in
cancer
therapy.
Resistance to treatment and rapid invasion
of cancer
cells are the main causes
of cancer
mortality.
To assess the treatment response, we cultured a 3-D MCF-7
cell
line overexpressing HER-2 and CD44 receptors.
The high density 3-D
cell
aggregation in the hollow fiber bioreactor (HFB) used for
the cell
culture was monitored with the use of proton magnetic resonance imaging ((1)H MRI).
The data also demonstrate that HA could be used to enhance treatment efficacy of trastuzumab and anti-HER-2 (clone CB11) in breast
cancer cell
cultures.
[MeSH-minor]
Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antigens, CD44 / immunology.
Cell
Line, Tumor.
Cell
Survival / drug effects. Chromatography, High Pressure Liquid / methods. DNA / administration & dosage. Drug Resistance, Neoplasm. Drug Synergism. Female. Humans. Hyaluronic Acid / administration & dosage. Lipids / administration & dosage. Magnetic Resonance Imaging / methods. Plasmids / administration & dosage. Receptor, ErbB-2 / immunology. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods. Trastuzumab
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(PMID = 19709839.001).
[ISSN]
1873-264X
[Journal-full-title]
Journal of pharmaceutical and biomedical analysis
[ISO-abbreviation]
J Pharm Biomed Anal
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antigens, CD44; 0 / Lipids; 0 / Lipofectamine; 9004-61-9 / Hyaluronic Acid; 9007-49-2 / DNA; EC 2.7.10.1 / Receptor, ErbB-2; P188ANX8CK / Trastuzumab
13.
Tougeron D, Tougeron-Brousseau B, Nasser Z, Benzerroug M, Lefebure B, Hamidou H, Michel P, Muraine M:
Unusual iris metastasis from anal cancer: a case report.
Dig Liver Dis
; 2009 Jul;41(7):e1-3
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[Title]
Unusual iris metastasis from
anal
cancer
: a case report.
We report a case of
anal
cancer
with iris metastasis and summarize the iris metastasis literature.
A 69 years old woman with a history of
anal
cancer
presented with a visual field loss.
Because of worse prognosis of metastatic
cancer
and any ocular complications, the patient was treated by radiotherapy which allowed a clinical improvement.
A review of medical records was performed to assess the clinical presentation,
diagnosis
and treatment.
Anal carcinoma
can metastasize to the iris.
[MeSH-major]
Anus
Neoplasms / pathology. Iris Neoplasms / secondary
Genetic Alliance.
consumer health - Anal Cancer
.
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consumer health - Anal Cancer
.
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(PMID = 18294934.001).
[ISSN]
1878-3562
[Journal-full-title]
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
[ISO-abbreviation]
Dig Liver Dis
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Netherlands
14.
Foster KW, Liu Z, Nail CD, Li X, Fitzgerald TJ, Bailey SK, Frost AR, Louro ID, Townes TM, Paterson AJ, Kudlow JE, Lobo-Ruppert SM, Ruppert JM:
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.
Oncogene
; 2005 Feb 24;24(9):1491-500
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[Title]
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates
squamous
epithelial dysplasia.
To examine the role of this zinc finger protein in
skin
, we expressed the wild-type human allele from inducible and constitutive promoters.
KLF4 caused a transitory apoptotic response and
the skin
progressed through phases of hyperplasia and dysplasia.
By 6 weeks, lesions exhibited nuclear KLF4 and other morphologic and molecular similarities to
squamous cell
carcinoma
in situ. p53 determined the patch size sufficient to establish lesions, as induction in a mosaic pattern produced
skin
lesions only when p53 was deficient.
The results suggest that KLF4 can function in the nucleus to induce
squamous
epithelial dysplasia, and indicate roles for p53 and epithelial-mesenchymal signaling in these early neoplastic lesions.
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(PMID = 15674344.001).
[ISSN]
0950-9232
[Journal-full-title]
Oncogene
[ISO-abbreviation]
Oncogene
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P30CA13148; United States / NCI NIH HHS / CA / P50 CA089019; United States / NCI NIH HHS / CA / P30 CA013148; United States / NCI NIH HHS / CA / R01 CA094030; United States / NCI NIH HHS / CA / R29 CA065686; United States / NCI NIH HHS / CA / CA89019; United States / NCI NIH HHS / CA / R01 CA065686; United States / NCI NIH HHS / CA / CA65686; United States / NCI NIH HHS / CA / CA094030
[Publication-type]
Journal Article; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
England
[Chemical-registry-number]
0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / GKLF protein; 0 / Kruppel-Like Transcription Factors; 0 / Transcription Factors; 80168379AG / Doxorubicin
[Other-IDs]
NLM/ NIHMS7908; NLM/ PMC1361530
15.
Alix-Panabières C, Vendrell JP, Slijper M, Pellé O, Barbotte E, Mercier G, Jacot W, Fabbro M, Pantel K:
Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer.
Breast Cancer Res
; 2009;11(3):R39
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[Title]
Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast
cancer
.
INTRODUCTION: We evaluated whether CK19, one of the main cytoskeleton proteins of epithelial cells, is released as full-length protein from viable tumor cells and whether this property is relevant for metastatic progression in breast
cancer
patients.
METHODS: EPISPOT (EPithelial ImmunoSPOT) assays were performed to analyze the release of full-length CK19 by
carcinoma
cells of various origins, and the sequence of CK19 was analyzed with mass spectrometry.
CK19-EPISPOT was used to detect disseminated tumor cells in bone marrow (BM) of 45 breast
cancer
patients who were then followed up over a median of 6 years.
RESULTS: CK19 was expressed and released by colorectal (HT-29, HCT116, Caco-2) and breast (MCF-7, SKBR3, and MDA-MB-231)
cancer cell
lines.
Functional experiments indicated that CK19 release was an active process and not simply the consequence
of cell
death.
CK19-releasing cells (RCs) were detectable in BM of 44% to 70% of breast
cancer
patients.
CONCLUSIONS: Full-length CK19 is released by viable epithelial tumor cells, and CK19-RCs might constitute a biologically active subset of breast
cancer
cells with high metastatic properties.
[MeSH-minor]
Adult. Aged. Bone Marrow Cells / metabolism.
Cell
Line, Tumor. Disease Progression. Epithelial Cells / metabolism. Epitopes. Female. Humans. Middle Aged. Multivariate Analysis. Neoplasm Metastasis
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]
(PMID = 19549321.001).
[ISSN]
1465-542X
[Journal-full-title]
Breast cancer research : BCR
[ISO-abbreviation]
Breast Cancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Epitopes; 0 / Keratin-19
[Other-IDs]
NLM/ PMC2716508
16.
Tajiri M, Kameda Y, Nakayama H, Sakamoto K:
Prognosis and morphometrical features of non-bronchioloalveolar cell adenocarcinoma: an assessment of the non-alveolar replacing area and high grade atypical area.
J Clin Pathol
; 2006 Mar;59(3):269-73
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[Title]
Prognosis and morphometrical features of non-bronchioloalveolar
cell
adenocarcinoma: an assessment of the non-alveolar replacing area and high grade atypical area.
AIM: It has become obvious that the prognosis of bronchioloalveolar
cell
carcinoma
(BAC) in small peripheral adenocarcinoma of the lung is good, but most cases actually treated as pulmonary adenocarcinoma in hospitals tend to be non-bronchioloalveolar
cell
carcinoma
(non-BAC).
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[ISSN]
0021-9746
[Journal-full-title]
Journal of clinical pathology
[ISO-abbreviation]
J. Clin. Pathol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC1860342
17.
Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, Clark K, Cai Z, Vincent S, Bottega S, Shen Q, Richardson A, Bosenburg M, Naber SP, DePinho RA, Kuperwasser C, Robinson MO:
Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice.
Proc Natl Acad Sci U S A
; 2009 Apr 28;106(17):7022-7
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[Title]
Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast
cancer
in mice.
Breast
cancer
development is a complex pathobiological process involving sequential genetic alterations in normal epithelial cells that results in uncontrolled growth in a permissive microenvironment.
Accordingly, physiologically relevant models of human breast
cancer
that recapitulate these events are needed to study
cancer
biology and evaluate therapeutic agents.
Here, we report the generation and utilization of the human breast
cancer
in mouse (HIM) model, which is composed of genetically engineered primary human breast epithelial organoids and activated human breast stromal cells.
Tumor development in the HIM model proceeds through defined histological stages of hyperplasia, DCIS to invasive
carcinoma
.
The HIM model is an experimentally tractable human in vivo system that holds great potential for advancing our basic understanding
of cancer
biology and for the discovery and testing of targeted therapies.
[MeSH-major]
Breast Neoplasms / genetics. Breast Neoplasms / pathology.
Cell
Transformation, Neoplastic / genetics.
Cell
Transformation, Neoplastic / pathology
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[ISSN]
1091-6490
[Journal-full-title]
Proceedings of the National Academy of Sciences of the United States of America
[ISO-abbreviation]
Proc. Natl. Acad. Sci. U.S.A.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Tumor Suppressor Protein p53; 136601-57-5 / Cyclin D1; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.1 / Receptor, ErbB-2; EC 2.7.7.49 / Telomerase; EC 3.6.5.2 / ras Proteins
18.
Gorjala P, Gary RK:
Beryllium sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types.
Biometals
; 2010 Dec;23(6):1061-73
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[Title]
Beryllium sulfate induces p21 CDKN1A expression and a senescence-like
cell
cycle arrest in susceptible
cancer cell
types.
It is not known whether Be(2+) can affect the proliferation
of cancer
cells, which are generally unsusceptible to senescence.
A172 glioblastoma and RKO colon
carcinoma
cell
lines each have wildtype p53, so these
cell
types have the potential to be responsive to agents that activate p53.
In A172 cells, BeSO(4) produced a G(0)/G(1)-phase
cell
cycle arrest and increased expression of senescence-associated β-galactosidase, an enzymatic marker of senescence.
In contrast, BeSO(4) had no effect on RKO cells, even though Be(2+) uptake was similar for the two
cell
types.
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]
[Cites]
Mol Cell Biol. 2000 Feb;20(3):760-9
[
10629032.001
]
(PMID = 20549306.001).
[ISSN]
1572-8773
[Journal-full-title]
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
[ISO-abbreviation]
Biometals
[Language]
ENG
[Grant]
United States / NCRR NIH HHS / RR / P20 RR016464; United States / NCRR NIH HHS / RR / RR016464-077332; United States / NCRR NIH HHS / RR / P20 RR-016464; United States / NCRR NIH HHS / RR / P20 RR016464-077332
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Tumor Suppressor Protein p53; 01UQ1KPC7E / beryllium sulfate; EC 3.2.1.23 / beta-Galactosidase; OW5102UV6N / Beryllium
[Other-IDs]
NLM/ NIHMS223050; NLM/ PMC2976805
19.
Muggerud AA, Johnsen H, Barnes DA, Steel A, Lønning PE, Naume B, Sørlie T, Børresen-Dale AL:
Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypes.
BMC Cancer
; 2006;6:59
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[Title]
Evaluation of MetriGenix custom 4D arrays applied for detection of breast
cancer
subtypes.
BACKGROUND: Previously, a total of five breast
cancer
subtypes have been identified based on variation in gene expression patterns.
In this study tumour samples from 27 breast
cancer
patients, previously subtyped by expression analysis using DNA microarrays, and four controls from normal breast tissue were included.
METHODS: We applied MetriGenix custom 4D arrays for the detection of previously defined molecular subtypes of breast
cancer
.
[MeSH-major]
Breast Neoplasms / classification.
Carcinoma
/ classification. Gene Expression Profiling / methods. Oligonucleotide Array Sequence Analysis / methods
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[Cites]
Cytogenet Cell Genet. 1999;87(1-2):47-52
[
10640810.001
]
[Cites]
Nature. 2000 Aug 17;406(6797):747-52
[
10963602.001
]
[Cites]
Anal Chem. 2001 Jun 1;73(11):2412-20
[
11403280.001
]
[Cites]
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74
[
11553815.001
]
[Cites]
Anal Chem. 2001 Dec 15;73(24):5777-83
[
11791544.001
]
[Cites]
Cancer Res. 2005 Mar 15;65(6):2170-8
[
15781628.001
]
[Cites]
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6567-72
[
12011421.001
]
[Cites]
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23
[
12829800.001
]
[Cites]
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[
12917485.001
]
[Cites]
Clin Cancer Res. 2003 Nov 15;9(15):5582-8
[
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]
[Cites]
Mol Biol Cell. 2004 Jun;15(6):2523-36
[
15034139.001
]
[Cites]
Expert Rev Mol Diagn. 2001 May;1(1):81-91
[
11901803.001
]
(PMID = 16536878.001).
[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC1421426
20.
Cortés-Gutiérrez EI, Dávila-Rodríguez MI, Zamudio-González EA, Aguado-Barrera ME, Vargas-Villarreal J, Cerda-Flores RM:
DNA damage in Mexican women with cervical dysplasia evaluated by comet assay.
Anal Quant Cytol Histol
; 2010 Aug;32(4):207-13
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DNA damage levels (none, low, medium and high) in the cervical epithelial cells of 31 women (10 with low grade
squamous
intraepithelial lesions [LSIL], 10 with high grade [HSIL] and 11 with no cervical lesion) were evaluated using the comet assay.
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(PMID = 21434521.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
United States
21.
Matsopoulos GK, Mouravliansky NA, Asvestas PA, Delibasis KK, Kouloulias V:
Thoracic non-rigid registration combining self-organizing maps and radial basis functions.
Med Image Anal
; 2005 Jun;9(3):237-54
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An automatic three-dimensional non-rigid registration scheme is proposed in this paper and applied to thoracic computed tomography (CT) data of patients with stage III non-small
cell
lung
cancer
(NSCLC).
[MeSH-major]
Carcinoma
, Non-Small-
Cell
Lung / radiography. Imaging, Three-Dimensional / methods. Lung Neoplasms / radiography. Pattern Recognition, Automated / methods. Radiographic Image Interpretation, Computer-Assisted / methods. Radiography, Thoracic / methods. Subtraction Technique
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(PMID = 15854844.001).
[ISSN]
1361-8415
[Journal-full-title]
Medical image analysis
[ISO-abbreviation]
Med Image Anal
[Language]
eng
[Publication-type]
Clinical Trial; Controlled Clinical Trial; Journal Article
[Publication-country]
England
22.
Subramanian N, Pichon E, Solomon SB:
Automatic registration using implicit shape representations: applications in intraoperative 3D rotational angiography to preoperative CTA registration.
Int J Comput Assist Radiol Surg
; 2009 Mar;4(2):141-6
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[MeSH-major]
Angiography / methods.
Carcinoma
, Hepatocellular / diagnostic imaging. Imaging, Three-Dimensional / methods. Liver Neoplasms / diagnostic imaging. Tomography, X-Ray Computed / methods. User-Computer Interface
MedlinePlus Health Information.
consumer health - CT Scans
.
MedlinePlus Health Information.
consumer health - Liver Cancer
.
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[Cites]
Med Image Anal. 2006 Jun;10(3):452-64
[
15979375.001
]
[Cites]
Acad Radiol. 2007 Nov;14 (11):1325-40
[
17964457.001
]
(PMID = 20033612.001).
[ISSN]
1861-6429
[Journal-full-title]
International journal of computer assisted radiology and surgery
[ISO-abbreviation]
Int J Comput Assist Radiol Surg
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Germany
23.
Silverberg MJ, Chao C, Leyden WA, Xu L, Tang B, Horberg MA, Klein D, Quesenberry CP Jr, Towner WJ, Abrams DI:
HIV infection and the risk of cancers with and without a known infectious cause.
AIDS
; 2009 Nov 13;23(17):2337-45
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[Title]
HIV infection and the risk
of cancers
with and without a known infectious cause.
OBJECTIVE: To evaluate the risk
of cancers
with and without a known infectious cause in HIV-infected persons.
METHODS: Adult HIV-infected and matched HIV-uninfected members of Kaiser Permanente followed between 1996 and 2007 for incident AIDS-defining
cancers
(ADCs), infection-related non-AIDS-defining
cancers
(NADCs;
anal
squamous cell
, vagina/vulva, Hodgkin's lymphoma, penis, liver, human papillomavirus-related oral cavity/pharynx, stomach) and infection-unrelated NADC (all other NADCs).
These results were largely influenced by
anal
squamous cell cancer
and Hodgkin's lymphoma.
Among infection-unrelated NADCs, other
anal
,
skin
, other head and neck, and lung
cancer
rates were higher and prostate
cancer
rates lower in HIV-infected persons.
Among all infection-unrelated NADCs, the rate ratio decreased over time only for lung
cancer
(P = 0.007).
CONCLUSION: In comparison with those without HIV infection, HIV-infected persons are at particular risk for
cancers
with a known infectious cause, although the higher risk has decreased in the antiretroviral therapy era.
Cancers
without a known infectious cause are modestly increased in HIV-infected persons compared with HIV-uninfected persons.
Genetic Alliance.
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.
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consumer health - HIV/AIDS
.
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.
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.
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.
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[
9521982.001
]
(PMID = 19741479.001).
[ISSN]
1473-5571
[Journal-full-title]
AIDS (London, England)
[ISO-abbreviation]
AIDS
[Language]
ENG
[Grant]
United States / NIAAA NIH HHS / AA / R01 AA016893; United States / NIAID NIH HHS / AI / K01 AI071725; United States / NIAID NIH HHS / AI / U01 AI069918-04; United States / NIAID NIH HHS / AI / K01 AI071725-03; United States / NIAID NIH HHS / AI / AI069918-04; United States / NIAID NIH HHS / AI / U01-AI069918; United States / NIAID NIH HHS / AI / K01AI071725; United States / NIAID NIH HHS / AI / AI071725-03; United States / NIAID NIH HHS / AI / U01 AI069918
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ NIHMS198381; NLM/ PMC2863991
24.
Nelson H:
Mayo Clinic office visit. Anal cancer. An interview with Heidi Nelson, M.D.
Mayo Clin Womens Healthsource
; 2009 Dec;13(12):6
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[Title]
Mayo Clinic office visit.
Anal
cancer
. An interview with Heidi Nelson, M.D.
[MeSH-major]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / therapy. Health Knowledge, Attitudes, Practice. Patient Education as Topic
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.
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.
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(PMID = 19881450.001).
[ISSN]
1091-0220
[Journal-full-title]
Mayo Clinic women's healthsource
[ISO-abbreviation]
Mayo Clin Womens Healthsource
[Language]
eng
[Publication-type]
Interview
[Publication-country]
United States
25.
Mi Y, Lou L:
ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein.
Br J Cancer
; 2007 Oct 8;97(7):934-40
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P-glycoprotein (P-gp) pumps multiple types of drugs out of the
cell
, using energy generated from ATP, and confers multidrug resistance (MDR) on
cancer
cells.
This study was designed to examine whether ZD6474 reverses P-gp-mediated MDR in
cancer
cells.
Here, we show that clinically achievable levels of ZD6474 reverse P-gp-mediated MDR of the P-gp-overexpressing
cell
lines derived from breast
cancer
, MCF-7/adriamycin (ADR), and human oral
epidermoid
carcinoma
, KBV200 to ADR, docetaxel, and vinorelbine.
Our results suggest that ZD6474 is capable of reversing MDR in
cancer
cells by directly inhibiting the function of P-gp, a finding that may have clinical implications for ZD6474.
[MeSH-major]
Cell
Proliferation / drug effects. Drug Resistance, Multiple / drug effects. Drug Resistance, Neoplasm / drug effects. P-Glycoprotein / antagonists & inhibitors. Piperidines / pharmacology. Quinazolines / pharmacology
Hazardous Substances Data Bank.
DOXORUBICIN
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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Cell Mol Life Sci. 2001 Jun;58(7):931-59
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11497241.001
]
(PMID = 17912240.001).
[ISSN]
0007-0920
[Journal-full-title]
British journal of cancer
[ISO-abbreviation]
Br. J. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antibiotics, Antineoplastic; 0 / N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; 0 / P-Glycoprotein; 0 / Piperidines; 0 / Quinazolines; 1N3CZ14C5O / Rhodamine 123; 80168379AG / Doxorubicin; EC 3.6.1.- / Adenosine Triphosphatases
[Other-IDs]
NLM/ PMC2360411
26.
Patel P, Hanson DL, Sullivan PS, Novak RM, Moorman AC, Tong TC, Holmberg SD, Brooks JT, Adult and Adolescent Spectrum of Disease Project and HIV Outpatient Study Investigators:
Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003.
Ann Intern Med
; 2008 May 20;148(10):728-36
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[Title]
Incidence of types
of cancer
among HIV-infected persons compared with the general population in the United States, 1992-2003.
BACKGROUND: Persons who are HIV-infected may be at higher risk for certain types
of cancer
than the general population.
OBJECTIVE: To compare
cancer
incidence among HIV-infected persons with incidence in the general population from 1992 to 2003.
PATIENTS: 54,780 HIV-infected persons in the Adult and Adolescent Spectrum of HIV Disease Project (47,832 patients) and the HIV Outpatient Study (6948 patients), who contributed 157,819 person-years of follow-up from 1992 to 2003, and 334,802,121 records from the Surveillance, Epidemiology, and End Results program of 13 geographically defined, population-based, central
cancer
registries.
MEASUREMENTS: Standardized rate ratios (SRRs) to compare
cancer
incidence in the HIV-infected population with standardized
cancer
incidence in the general population.
RESULTS: The incidence of the following types of non-AIDS-defining
cancer
was significantly higher in the HIV-infected population than in the general population:
anal
(SRR, 42.9 [95% CI, 34.1 to 53.3]), vaginal (21.0 [CI, 11.2 to 35.9]), Hodgkin lymphoma (14.7 [CI, 11.6 to 18.2]), liver (7.7 [CI, 5.7 to 10.1]), lung (3.3 [CI, 2.8 to 3.9]), melanoma (2.6 [CI, 1.9 to 3.6]), oropharyngeal (2.6 [CI, 1.9 to 3.4]), leukemia (2.5 [CI, 1.6 to 3.8]), colorectal (2.3 [CI, 1.8 to 2.9]), and renal (1.8 [CI, 1.1 to 2.7]).
The incidence of prostate
cancer
was significantly lower among HIV-infected persons than the general population (SRR, 0.6 [CI, 0.4 to 0.8]).
Only the relative incidence of
anal
cancer
increased over time.
LIMITATIONS: Lower ascertainment
of cancer
in the HIV cohorts may result in a potential bias to underestimate rate disparities.
Tobacco use as a risk factor and the effect of changes in
cancer
screening practices could not be evaluated.
CONCLUSION: The incidence of many types of non-AIDS-defining
cancer
was higher among HIV-infected persons than among the general population from 1992 to 2003.
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Male. Middle Aged. Observation. Prospective Studies. Risk Factors. Tobacco Use
Disorder
/ complications. United States / epidemiology
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Cited by Patents in
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[SummaryForPatientsIn]
Ann Intern Med. 2008 May 20;148(10):I46
[
18490669.001
]
(PMID = 18490686.001).
[ISSN]
1539-3704
[Journal-full-title]
Annals of internal medicine
[ISO-abbreviation]
Ann. Intern. Med.
[Language]
eng
[Grant]
United States / PHS HHS / / 200-2006-18797
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
[Publication-country]
United States
[Investigator]
Thompson M; Sinclair E; Cohen D; Davidson A; Rietmeijer C; Garland W; Wohl A; Morse A; Wotring L; Mokotoff E; Murrill C; Bernard MA; Amill A; de los Angeles Gomez M; Miranda S; Buskin S; Barash E; Odem S; Keiser P; Awosika-Olumo A; Wood KC; Baker RK; Palella FJ; Chmiel JS; Cheley J; Lichtenstein KA; Greenberg KS; Young B; Widick B; Stewart C; Zellner P; Yangco BG; Halkias K; Ward DJ; Fiorentino CA; Ording-Bauer L; Kelly R; Esteves J; Tedaldi EM; Christian R; Ruley F; Marzouk JB; Phelps RT; Rachel M; McCabe RE; Rachel M; Novak RM; Uy JP; Wendrow A
27.
Gao Y, Hu N, Han X, Giffen C, Ding T, Goldstein AM, Taylor PR:
Jasmine tea consumption and upper gastrointestinal cancer in China.
Cancer Causes Control
; 2009 Dec;20(10):1997-2007
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[Title]
Jasmine tea consumption and upper gastrointestinal
cancer
in China.
INTRODUCTION: Epidemiological data on green/jasmine tea and esophageal as well as gastric
cancer
are limited and inconclusive.
METHODS: In order to study the effect of jasmine tea in upper gastrointestinal (UGI)
cancers
, we evaluated 600 esophageal
squamous cell
carcinoma
(ESCC), 598 gastric cardia
cancer
(GCA), and 316 gastric non-cardia
cancer
(GNCA) cases and 1,514 age-, gender-, and neighborhood-matched controls.
CONCLUSION: Overall, we found no evidence for a protective effect of tea in esophageal or gastric
cancer
.
Further studies of the potential effects of thermal damage, tea quality, and water quality on UGI
cancers
are suggested.
[MeSH-major]
Carcinoma
,
Squamous Cell
/ etiology. Drinking Behavior / physiology. Gastrointestinal Neoplasms / etiology. Jasminum. Plant Preparations. Tea
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]
(PMID = 19597950.001).
[ISSN]
1573-7225
[Journal-full-title]
Cancer causes & control : CCC
[ISO-abbreviation]
Cancer Causes Control
[Language]
eng
[Grant]
United States / Intramural NIH HHS / / Z01 CP000185-03
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Plant Preparations; 0 / Tea
[Other-IDs]
NLM/ NIHMS339598; NLM/ PMC3236106
28.
Taub AF:
Photodynamic therapy: other uses.
Dermatol Clin
; 2007 Jan;25(1):101-9
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Mainstream uses for photodynamic therapy (PDT) in dermatology include nonmelanoma
skin cancer
and its precursors, acne vulgaris, photorejuvenation, and hidradenitis suppurativa.
Many other dermatologic entities have been treated with PDT, including psoriasis, lichen planus, lichen sclerosus, scleroderma, cutaneous T
cell
lymphoma, alopecia areata, verruca vulgaris, Darier's disease and tinea infections.
Nondermatologic applications include
anal
and vulva
carcinoma
, palliation of metastatic breast
cancer
to
skin
, Barrett's esophagus, and macular degeneration of the retina.
PDT also has found to be useful in immunologic and inflammatory disorders, neoplasias other than
skin cancer
, and infections.
[MeSH-major]
Infection / drug therapy. Neoplasms / drug therapy. Photochemotherapy.
Skin
Diseases / drug therapy
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(PMID = 17126748.001).
[ISSN]
0733-8635
[Journal-full-title]
Dermatologic clinics
[ISO-abbreviation]
Dermatol Clin
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
59
29.
Asolkar RN, Freel KC, Jensen PR, Fenical W, Kondratyuk TP, Park EJ, Pezzuto JM:
Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola.
J Nat Prod
; 2009 Mar 27;72(3):396-402
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Moderate cytotoxicity was observed with the human colon
carcinoma
cell
line HCT-116, but no cytotoxic effect was noted with cultured RAW cells.
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[Cites]
Cell Cycle. 2008 Apr 15;7(8):1020-35
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18414053.001
]
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]
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[ErratumIn]
J Nat Prod. 2010 Apr 23;73(4):796
(PMID = 19117399.001).
[ISSN]
1520-6025
[Journal-full-title]
Journal of natural products
[ISO-abbreviation]
J. Nat. Prod.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / P01 CA048112; United States / NCI NIH HHS / CA / R37 CA044848; United States / NCI NIH HHS / CA / CA048112-150007; United States / NCI NIH HHS / CA / P01 CA048112-150007; United States / NCI NIH HHS / CA / R37 CA044848-22; United States / NCI NIH HHS / CA / P01 CA48112; United States / NCI NIH HHS / CA / CA044848-22; United States / FIC NIH HHS / TW / U01 TW007401; United States / FIC NIH HHS / TW / U01-TW007401-01
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Depsipeptides; 0 / Lipopolysaccharides; 0 / NF-kappa B; 0 / Tumor Necrosis Factor-alpha; 0 / arenamide A; 0 / arenamide B; 0 / arenamide C; 31C4KY9ESH / Nitric Oxide; K7Q1JQR04M / Dinoprostone
[Other-IDs]
NLM/ NIHMS91488; NLM/ PMC2837138
30.
Pineda CE, Berry JM, Jay N, Palefsky JM, Welton ML:
High resolution anoscopy in the planned staged treatment of anal squamous intraepithelial lesions in HIV-negative patients.
J Gastrointest Surg
; 2007 Nov;11(11):1410-5; discussion 1415-6
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[Title]
High resolution anoscopy in the planned staged treatment of
anal
squamous
intraepithelial lesions in HIV-negative patients.
Anal
dysplasia (low-grade
squamous
intraepithelial lesions, LSIL; high-grade
squamous
intraepithelial lesions, HSIL) is a challenging disease for the surgeon.
We reviewed 42 patients that underwent high-resolution anoscopy (HRA)-targeted surgical therapy of
anal
dysplasia in the past 10 years.
Patients were followed up in the
Anal
Neoplasia Clinic with physical examination, cytology, HRA, and biopsy if indicated.
Progression to HSIL was seen in one patient with LSIL and to
squamous cell
carcinoma
in one patient with HSIL despite therapy.
HRA-targeted surgical therapy coupled with surveillance and re-treatment with office-based therapies offered an effective method in controlling
anal
dysplasia in the immunocompetent patient.
Morbidity is minimal, and our progression to
cancer
rate is low (2.4%).
[MeSH-major]
Anus
Neoplasms / surgery.
Carcinoma
in Situ / surgery.
Carcinoma
,
Squamous Cell
/ surgery
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[Cites]
Dis Colon Rectum. 2006 Jan;49(1):36-40
[
16283561.001
]
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[
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]
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11357031.001
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Dis Colon Rectum. 1997 Nov;40(11):1286-93
[
9369101.001
]
(PMID = 17710507.001).
[ISSN]
1091-255X
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
31.
Das DK, Sharma PN:
Intranuclear cytoplasmic inclusions and nuclear grooves in fine needle aspiration smears of papillary thyroid carcinoma and its variants: advantage of the count under an oil-immersion objective over a high-power objective.
Anal Quant Cytol Histol
; 2005 Apr;27(2):83-94
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[Title]
Intranuclear cytoplasmic inclusions and nuclear grooves in fine needle aspiration smears of papillary thyroid
carcinoma
and its variants: advantage of the count under an oil-immersion objective over a high-power objective.
OBJECTIVE: To determine the advantage of examining fine needle aspiration (FNA) smears of papillary thyroid
carcinoma
(PTC) under a 100 x oil-immersion objective, which is capable of optically sectioning the cells.
STUDY DESIGN: Two hundred neoplastic cells were counted under a high-power (40x) objective as well as oil-immersion (100x) objective in 54 PTC cases classified into variants: 14 follicular neoplasms, 8 Hürthle
cell
neoplasms, 5 medullary thyroid carcinomas and 9 hyperplastic lesions.
In PTC cases, the mean
cell
count, 10.1 (+/- 1.75 SE) with INCIs, under the oil-immersion objective was significantly higher than the count, 6.1 (+/- 1.32 SE), under the high-power objective (p = 0.023).
In PTC the mean
cell
count, 88.0 (+/- 4.96 SE), with grooved nuclei under the oil-immersion objective was also significantly higher than the count, 69.5 (+/- 4.87 SE), under the high-power objective (p = 0.010).
In PTC the mean
cell
counts with INCIs as well as grooved nuclei under the oil-immersion objective were significantly higher than those of follicular neoplasms, Hürthle
cell
neoplasms, medullary
carcinoma
and hyperplastic lesions.
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(PMID = 15913201.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Oils
32.
Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, Su D, Sano M, Lytwyn A, Chapman W, Mahony J:
Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology.
Cancer Epidemiol Biomarkers Prev
; 2009 Jul;18(7):1986-92
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[Title]
Screening for HIV-associated
anal
cancer
: correlation of HPV genotypes, p16, and E6 transcripts with
anal
pathology.
BACKGROUND: HIV-positive men with a history of
anal
-receptive intercourse are at risk for
anal
cancer
.
We determined whether human papilloma virus (HPV) biomarkers were correlated with
anal
pathology in these men.
The number of HPV genotypes per
anal
swab was higher for
anal
intraepithelial neoplasia (AIN) 2/3 than for normal or AIN 1 histology [median, 5 types (interquartile range) (IQR), 3-7 versus 3.5 (IQR), 2-6; P = 0.0005].
CONCLUSIONS: The presence of high-grade
anal
pathology (AIN 2/3) in HIV-positive men was associated with multiple HPV genotypes, HPV genotypes 16 and 31, and HPV 16 viral load.
[MeSH-major]
Alphapapillomavirus / genetics.
Anus
Neoplasms / epidemiology.
Carcinoma
in Situ / epidemiology. Genes, p16. HIV Seropositivity / virology. Oncogene Proteins, Viral / genetics. Repressor Proteins / genetics
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(PMID = 19567510.001).
[ISSN]
1538-7755
[Journal-full-title]
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
[ISO-abbreviation]
Cancer Epidemiol. Biomarkers Prev.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Viral; 0 / E6 protein, Human papillomavirus type 16; 0 / Oncogene Proteins, Viral; 0 / Repressor Proteins
33.
Kuramitsu Y:
Can proteomics lead to the discovery of real biomarkers for HCC?
World J Hepatol
; 2010 Feb 27;2(2):55-7
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The development of proteomics technologies has lead to a great deal of effort being focused on the identification of biomarkers for
cancers
.
Although many papers have reported candidate biomarkers for hepatocellular carcinomas (HCCs) in particular, so far none of these candidate biomarkers have been used either for
diagnosis or
therapy intreating patients.
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(PMID = 21160973.001).
[ISSN]
1948-5182
[Journal-full-title]
World journal of hepatology
[ISO-abbreviation]
World J Hepatol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
China
[Other-IDs]
NLM/ PMC2999271
[Keywords]
NOTNLM ; Biomarker / Hepatocellular carcinoma / Mass spectrometry / Proteomics / Two-dimensional polyacrylamide gel electrophoresis
34.
Dhanarasu S, Selvam M, Salama SM, Shanmugam M, Sethuraman P:
Terminalia Arjuna (Roxb.) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene- induced Hamster Buccal Pouch Carcinogenesis.
Oman Med J
; 2010 Oct;25(4):276-81
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OBJECTIVES: Oral
cancer
is the fifth most frequent
cancer
worldwide and India has recorded the highest incidence (40-50%) of oral malignancy.
METHODS: Male Syrian golden hamsters painted with 0.5% 7,12-dimethylbenz[a]anthracene on the buccal pouches and developed oral
squamous cell
carcinoma
were included in this study.
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(PMID = 22043357.001).
[ISSN]
2070-5204
[Journal-full-title]
Oman medical journal
[ISO-abbreviation]
Oman Med J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Oman
[Other-IDs]
NLM/ PMC3191666
35.
Giuliano AR, Tortolero-Luna G, Ferrer E, Burchell AN, de Sanjose S, Kjaer SK, Muñoz N, Schiffman M, Bosch FX:
Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions.
Vaccine
; 2008 Aug 19;26 Suppl 10:K17-28
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[Title]
Epidemiology of human papillomavirus infection in men,
cancers
other than cervical and benign conditions.
The association of HPV DNA with several different
ano
-genital
cancers
other than cervical has been reported for the vulva, vagina,
anus
and penis.
HPV DNA has also been identified in head and neck
cancers
in the oral cavity, the oropharynx and the larynx in both sexes.
In men, 80-85% of
anal
cancers
and close to 50% of penile
cancers
are associated with HPV infection.
In women, HPV DNA is prevalent in 36-40% vulvar
cancer
cases and close to 90% of vaginal
cancers
.
Among HPV DNA positive
ano
-genital
cancer
cases, HPV-16 is the most frequently found followed distantly by HPV-18.
We summarize the evidence linking HPV in the epidemiology and etiology
of cancers
of the vulva, vagina,
anus
and oropharynx and present recent estimates of the burden of and HPV type distribution in genital warts and in cases of HPV infection of the airways.
[MeSH-minor]
Anus
Neoplasms / virology. Female. Humans. Male. Papillomaviridae / immunology. Papillomaviridae / pathogenicity. Respiratory Tract Infections / epidemiology. Respiratory Tract Infections / virology. Uterine Cervical Diseases / epidemiology. Uterine Cervical Diseases / virology
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(PMID = 18847554.001).
[ISSN]
0264-410X
[Journal-full-title]
Vaccine
[ISO-abbreviation]
Vaccine
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / R01 CA098803
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
Netherlands
[Number-of-references]
91
[Other-IDs]
NLM/ NIHMS73638; NLM/ PMC4366004
36.
Okoń K, Sińczak-Kuta A, Stachura J:
Renal papillary carcinoma classification into subtypes may be reproduced by nuclear morphometry.
Anal Quant Cytol Histol
; 2009 Apr;31(2):109-17
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[Title]
Renal papillary
carcinoma
classification into subtypes may be reproduced by nuclear morphometry.
OBJECTIVE: To analyze relationships between nuclear features of papillary renal
cell
carcinoma
(PapRCC) subtypes.
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(PMID = 19402388.001).
[ISSN]
0884-6812
[Journal-full-title]
Analytical and quantitative cytology and histology
[ISO-abbreviation]
Anal. Quant. Cytol. Histol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
37.
Murph MM, Liu W, Yu S, Lu Y, Hall H, Hennessy BT, Lahad J, Schaner M, Helland A, Kristensen G, Børresen-Dale AL, Mills GB:
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
PLoS One
; 2009;4(5):e5583
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[Title]
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian
carcinoma
and worsened prognosis.
Malignant ascites fluid is rich in LPA, and LPA receptors are aberrantly expressed by ovarian
cancer
cells, implicating LPA in the initiation and progression of ovarian
cancer
.
However, there is an absence of systematic data critically analyzing the transcriptional changes induced by LPA in ovarian
cancer
.
METHODOLOGY AND PRINCIPAL FINDINGS: In this study, gene expression profiling was used to examine LPA-mediated transcription by exogenously adding LPA to human epithelial ovarian
cancer
cells for 24 h to mimic long-term stimulation in the tumor microenvironment.
The resultant transcriptional profile comprised a 39-gene signature that closely correlated to serous epithelial ovarian
carcinoma
.
Hierarchical clustering of ovarian
cancer
patient specimens demonstrated that the signature is associated with worsened prognosis.
They have a higher frequency of stage IIIc serous
carcinoma
and a greater proportion is deceased.
Among the 39-gene signature, a group of seven genes associated with
cell
adhesion recapitulated the results.
Out of those seven, claudin-1, an adhesion molecule and phenotypic epithelial marker, is the only independent biomarker of serous epithelial ovarian
carcinoma
.
Knockdown of claudin-1 expression in ovarian
cancer
cells reduces LPA-mediated cellular adhesion, enhances suspended cells and reduces LPA-mediated migration.
CONCLUSIONS: The data suggest that transcriptional events mediated by LPA in the tumor microenvironment influence tumor progression through modulation
of cell
adhesion molecules like claudin-1 and, for the first time, report an LPA-mediated expression signature in ovarian
cancer
that predicts a worse prognosis.
[MeSH-minor]
Blotting, Western.
Cell
Adhesion / genetics.
Cell
Adhesion / physiology.
Cell
Line, Tumor.
Cell
Proliferation.
Cell
Survival / genetics.
Cell
Survival / physiology. Claudin-1. Cluster Analysis. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. Membrane Proteins / genetics. Oligonucleotide Array Sequence Analysis. Polymerase Chain Reaction
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(PMID = 19440550.001).
[ISSN]
1932-6203
[Journal-full-title]
PloS one
[ISO-abbreviation]
PLoS ONE
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / P01 CA099031; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / P50 CA098258
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / CLDN1 protein, human; 0 / Claudin-1; 0 / Lysophospholipids; 0 / Membrane Proteins; 22002-87-5 / lysophosphatidic acid
[Other-IDs]
NLM/ PMC2679144
38.
Choi AO, Brown SE, Szyf M, Maysinger D:
Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells.
J Mol Med (Berl)
; 2008 Mar;86(3):291-302
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[Title]
Quantum dot-induced epigenetic and genotoxic changes in human breast
cancer
cells.
We examined here the epigenomic and genotoxic response to cadmium telluride quantum dots (QDs) in human breast
carcinoma
cells.
Consequential decrease in
cell
viability was in part prevented by the p53 inhibitor pifithrin-alpha, suggesting that p53 translocation contributes to QD-induced cytotoxicity.
[MeSH-minor]
Acetylation. Animals. Apoptosis Regulatory Proteins / genetics. Apoptosis Regulatory Proteins / metabolism.
Cell
Line, Tumor.
Cell
Nucleus / metabolism.
Cell
Nucleus / ultrastructure. Chromatin / metabolism. Chromatin / ultrastructure. Gene Expression Regulation, Neoplastic. Histones / metabolism. Humans. Mitochondria / ultrastructure. Models, Biological. PC12 Cells. Phosphorylation. Protein Processing, Post-Translational. Protein Transport. RNA, Messenger / genetics. RNA, Messenger / metabolism. Rats. Tumor Suppressor Protein p53 / metabolism
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[ISSN]
0946-2716
[Journal-full-title]
Journal of molecular medicine (Berlin, Germany)
[ISO-abbreviation]
J. Mol. Med.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Apoptosis Regulatory Proteins; 0 / Chromatin; 0 / Histones; 0 / RNA, Messenger; 0 / Tumor Suppressor Protein p53
39.
Bravo SB, Garcia-Rendueles ME, Perez-Romero S, Cameselle-Teijeiro J, Rodrigues JS, Barreiro F, Alvarez CV:
Expression of exogenous proteins and short hairpin RNAs in human primary thyrocytes.
Anal Biochem
; 2010 May 15;400(2):219-28
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Recently, it has been shown that commercial human thyroid lines were in fact derived from colon, mammary
carcinoma
, or melanoma.
Others have demonstrated the absence of a common pattern of gene expression between available thyroid
cancer cell
lines and tumors from patients.
Nucleofection was unquestionably the most efficient even for promoter regulation studies, and it was effective in cultures from different origins as normal thyroid, papillary
carcinoma
, or lymphoid node metastasis.
The Lens.
Cited by Patents in
.
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[Copyright]
Copyright 2010 Elsevier Inc. All rights reserved.
(PMID = 20122891.001).
[ISSN]
1096-0309
[Journal-full-title]
Analytical biochemistry
[ISO-abbreviation]
Anal. Biochem.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Proteins; 63231-63-0 / RNA
40.
Williams SJ, Cvetkovic D, Hamilton TC:
Vitamin A metabolism is impaired in human ovarian cancer.
Gynecol Oncol
; 2009 Mar;112(3):637-45
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[Title]
Vitamin A metabolism is impaired in human ovarian
cancer
.
METHODS: We assessed CRBP1 expression by immunohistochemistry in ovaries prophylactically removed from women with a genetic risk for ovarian
cancer
.
HPLC analysis of vitamin A metabolism showed production of retinoic acid in four independent, normal human ovarian surface epithelial (HOSE)
cell
cultures upon exposure to retinol.
However, only one of two SV40-immortalized HOSE
cell
lines made RA, while none of the ovarian
carcinoma
cell
lines produced detectable RA due to complete loss of RALDH2.
CONCLUSIONS: The impaired conversion of retinol to RA in ovarian
cancer
cells and decreased CRBP1 protein expression in prophylactic oophorectomies support our hypothesis that concomitant losses of vitamin A metabolism and CRBP1 expression contribute to ovarian oncogenesis.
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[
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]
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[ISSN]
1095-6859
[Journal-full-title]
Gynecologic oncology
[ISO-abbreviation]
Gynecol. Oncol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA107195; United States / NCI NIH HHS / CA / R01 CA107195-01A2; United States / NCI NIH HHS / CA / CA107195-01A2; United States / NCI NIH HHS / CA / P50 CA083638-040001; United States / NCI NIH HHS / CA / CA107195-03; United States / NCI NIH HHS / CA / CA107195-02; United States / NCI NIH HHS / CA / P50 CA083638-030001; United States / NCI NIH HHS / CA / CA083638-030001; United States / NCI NIH HHS / CA / R01 CA107195-03; United States / NCI NIH HHS / CA / CA 83638; United States / NCI NIH HHS / CA / R01 CA107195-04; United States / NCI NIH HHS / CA / R01 CA107195-02; United States / NCI NIH HHS / CA / CA107195-04; United States / NCI NIH HHS / CA / P50 CA083638; United States / NCI NIH HHS / CA / CA083638-040001
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Retinol-Binding Proteins, Cellular; 11103-57-4 / Vitamin A; 5688UTC01R / Tretinoin; RR725D715M / Retinaldehyde
[Other-IDs]
NLM/ NIHMS102172; NLM/ PMC2737361
41.
Alvarez J, de Pokomandy A, Rouleau D, Ghattas G, Vézina S, Coté P, Allaire G, Hadjeres R, Franco EL, Coutlée F, HIPVIRG Study Group:
Episomal and integrated human papillomavirus type 16 loads and anal intraepithelial neoplasia in HIV-seropositive men.
AIDS
; 2010 Sep 24;24(15):2355-63
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[Title]
Episomal and integrated human papillomavirus type 16 loads and
anal
intraepithelial neoplasia in HIV-seropositive men.
OBJECTIVES: To assess levels of episomal and integrated human papillomavirus type 16 (HPV-16) loads in HIV-seropositive men who have sex with men (MSM) in
anal
infection and to study the association between episomal and integrated HPV-16 loads and
anal
intraepithelial neoplasia (AIN).
Overall, 135 (54.7%) men provided 665 HPV-16-positive
anal
samples.
RESULTS: The HPV-16 DNA forms in
anal
samples were characterized as episomal only in 627 samples (94.3%), mixed in 22 samples (3.3%) and integrated only in nine samples (1.4%).
HPV-16 episomal load [odds ratio (OR) = 1.5, 95% confidence interval (CI) 1.1-2.1], number of HPV types (OR = 1.4, 95% CI 1.1-1.8) and current smoking (OR = 4.8, 95% CI 1.3-18.6) were associated with high-grade AIN (AIN-2,3) after adjusting for age and CD4
cell
counts.
[MeSH-major]
Anus
Neoplasms / immunology.
Carcinoma
,
Squamous Cell
/ immunology. HIV Seropositivity / immunology. Human papillomavirus 16 / immunology. Papillomavirus Infections / immunology. Plasmids / immunology
Genetic Alliance.
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.
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(PMID = 20706109.001).
[ISSN]
1473-5571
[Journal-full-title]
AIDS (London, England)
[ISO-abbreviation]
AIDS
[Language]
eng
[Grant]
Canada / Canadian Institutes of Health Research / /
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / DNA, Viral
[Investigator]
Allaire G; Baril JG; Boissonnault M; Charest L; Charron MA; Coté S; Coté P; Coutlée F; de Pokomandy A; Dion H; Dufresne S; Falutz J; Fortin C; Franco EL; Ghattas G; Gilmore N; Gorska I; Hadjeres R; Junod P; Klein M; Lalonde R; Laplante F; Leblanc R; Legault D; Lessard B; Longpré D; McLeod J; Maziade JP; Murphy D; Nguyen VK; O'Brien R; Phaneuf D; Rouleau D; Routy JP; Szabo J; Tessier D; Thomas R; Toma E; Tremblay C; Trépanier JM; Trottier B; Tsoukas C; Turner H; Vezina S
42.
Dharmu I, Ramamurty N, Kannan R, Babu M:
Cytotoxic effect of achatinin(H) (lectin) from Achatina fulica against a human mammary carcinoma cell line (MCF7).
In Vitro Cell Dev Biol Anim
; 2007 Sep-Oct;43(8-9):306-14
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[Title]
Cytotoxic effect of achatinin(H) (lectin) from Achatina fulica against a human mammary
carcinoma
cell
line (MCF7).
The hemolymph-derived achatinin(H) (lectin) from Achatina fulica showed a marked cytotoxic effect on MCF7, a human mammary
carcinoma
cell
line.
MCF7 cells showed significant morphological changes leading to
cell
death.
The above
cell
death was observed after 48 h of treatment with 8 microg/ml when compared to untreated cells.
Fluorescence-activated
cell
sorting analysis of the
cell
cycle showed a significant increase in S-phase in MCF7 cells after 48 h of achatinin(H) treatment.
The cells were arrested in G(2)/M phase of the
cell
cycle after 48 h with significant changes in
cell
viability.
[MeSH-minor]
Animals. Antioxidants / metabolism. Biomarkers, Tumor / metabolism. Blotting, Western.
Cell
Count.
Cell
Cycle / drug effects.
Cell
Death / drug effects.
Cell
Line, Tumor.
Cell
Survival / drug effects. DNA, Neoplasm / isolation & purification. Electrophoresis, Agar Gel. Female. Flow Cytometry. Humans
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[ErratumIn]
In Vitro Cell Dev Biol Anim. 2007 Nov-Dec;43(10):379-81
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[ISSN]
1071-2690
[Journal-full-title]
In vitro cellular & developmental biology. Animal
[ISO-abbreviation]
In Vitro Cell. Dev. Biol. Anim.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
[Chemical-registry-number]
0 / Antioxidants; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Lectins; 0 / achatinin(H)
43.
Aalen OO, Gunnes N:
A dynamic approach for reconstructing missing longitudinal data using the linear increments model.
Biostatistics
; 2010 Jul;11(3):453-72
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Analysis of quality of life data from a
cancer
clinical trial is analyzed and presented.
[MeSH-minor]
Carcinoma
, Non-Small-
Cell
Lung / drug therapy.
Carcinoma
, Non-Small-
Cell
Lung / radiotherapy. Clinical Trials, Phase III as Topic. Computer Simulation. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / radiotherapy. Patient Dropouts. Quality of Life
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[ISSN]
1468-4357
[Journal-full-title]
Biostatistics (Oxford, England)
[ISO-abbreviation]
Biostatistics
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC3293429
44.
Janani P, Sivakumari K, Geetha A, Ravisankar B, Parthasarathy C:
Chemopreventive effect of bacoside A on N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.
J Cancer Res Clin Oncol
; 2010 May;136(5):759-70
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Bacoside A, the active constituent of Bacopa monniera Linn., is anticipated to play a role in chemoprevention of liver
cancer
.
Bacoside A co-treatment maintained
the N
-nitrosodiethylamine-induced alterations at near normal level.
CONCLUSIONS: From our findings we conclude that bacoside A is effective to prevent DEN-induced hepatocellular
carcinoma
by quenching lipid peroxidation and enhancing antioxidant status through free radical scavenging mechanism and having potential of protecting endogenous enzymatic and non-enzymatic antioxidant activity.
[MeSH-major]
Anticarcinogenic Agents / pharmacology.
Carcinoma
, Hepatocellular / prevention & control. Diethylnitrosamine / antagonists & inhibitors. Liver Neoplasms, Experimental / prevention & control. Saponins / pharmacology. Triterpenes / pharmacology
Hazardous Substances Data Bank.
N-NITROSODIETHYLAMINE
.
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(PMID = 19916024.001).
[ISSN]
1432-1335
[Journal-full-title]
Journal of cancer research and clinical oncology
[ISO-abbreviation]
J. Cancer Res. Clin. Oncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
0 / Anticarcinogenic Agents; 0 / Antioxidants; 0 / Carcinogens; 0 / Plant Extracts; 0 / Saponins; 0 / Triterpenes; 0 / bacoside A; 3IQ78TTX1A / Diethylnitrosamine
45.
Fox PA:
Human papillomavirus and anal intraepithelial neoplasia.
Curr Opin Infect Dis
; 2006 Feb;19(1):62-6
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[Title]
Human papillomavirus and
anal
intraepithelial neoplasia.
PURPOSE OF REVIEW: A review of recent developments in the understanding of the natural history of
anal
squamous
carcinoma
arising from areas of high-grade
anal
intraepithelial neoplasia.
RECENT FINDINGS:
Anal
intraepithelial neoplasia is a consequence of chronic human papillomavirus infection in the
anal
canal and appears to be driven by high viral loads of human papillomavirus.
Anal
intraepithelial neoplasia is equally prevalent in different age groups of men who have sex with men, but in other respects what is known of its natural history resembles that of cervical intraepithelial neoplasia.
HIV-positives who practise receptive
anal
intercourse are at highest risk of
anal
intraepithelial neoplasia.
Screening is easy to perform using cytology; the limitations of
anal
cytology being similar to those of cervical cytology.
[MeSH-major]
Anus
Neoplasms.
Carcinoma
in Situ.
Carcinoma
,
Squamous Cell
. Papillomaviridae / pathogenicity. Papillomavirus Infections
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(PMID = 16374220.001).
[ISSN]
0951-7375
[Journal-full-title]
Current opinion in infectious diseases
[ISO-abbreviation]
Curr. Opin. Infect. Dis.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Number-of-references]
35
46.
Hampl M:
Prevention of human papilloma virus-induced preneoplasia and cancer by prophylactic HPV vaccines.
Minerva Med
; 2007 Apr;98(2):121-30
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[Title]
Prevention of human papilloma virus-induced preneoplasia and
cancer
by prophylactic HPV vaccines.
Persistent infection with human papilloma virus (HPV) is a necessary condition for the development of cervical, most of the vulvar and
anal carcinoma
and their precursors.
Only persistent infections predispose to the development of genital preneoplasia and
cancer
.
These vaccines constitute a milestone in the battle against cervical
carcinoma
, which is the second most common
cancer
in young women in Europe, with 33,500 new cases diagnosed every year.
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(PMID = 17519854.001).
[ISSN]
0026-4806
[Journal-full-title]
Minerva medica
[ISO-abbreviation]
Minerva Med.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Italy
[Chemical-registry-number]
0 / Papillomavirus Vaccines
47.
Xu CM, Qiao CH:
Loss of fragile histidine triad protein expression in inflammatory bowel disease.
World J Gastroenterol
; 2006 Dec 7;12(45):7355-60
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CONCLUSION: Our results show that FHIT protein expression is completely absent or reduced in IBD, suggesting that the FHIT gene might be associated with the oncogenesis and progression of IBD, an early event from inflammatory conditions to
carcinoma
in IBD.
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[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
China
[Chemical-registry-number]
0 / Neoplasm Proteins; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
[Other-IDs]
NLM/ PMC4087498
48.
Negri G, Moretto G, Menia E, Vittadello F, Kasal A, Mian C, Egarter-Vigl E:
Immunocytochemistry of p16INK4a in liquid-based cervicovaginal specimens with modified Papanicolaou counterstaining.
J Clin Pathol
; 2006 Aug;59(8):827-30
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METHODS: Immunocytochemical analyses were carried out with p16(INK4a) and modified Papanicolaou counterstain on 81 liquid-based samples, including 23 of within normal limits (WNL), 6 of low-grade
squamous
intraepithelial lesion (LSIL), 20 of high-grade
squamous
intraepithelial lesion (HSIL), 16 of atypical
squamous
cells of undetermined significance (ASC-US) and 16 of atypical
squamous
cells, high-grade lesion cannot be excluded (ASC-H).
The intensity of immunostaining in cases
of squamous
intraepithelial lesion (SIL) was assessed using a 0-3 scoring system.
[MeSH-major]
Biomarkers, Tumor / analysis. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Uterine Cervical Neoplasms /
diagnosis
[MeSH-minor]
Carcinoma
,
Squamous Cell
/
diagnosis
. Cervical Intraepithelial Neoplasia /
diagnosis
.
Diagnosis
, Differential. Feasibility Studies. Female. Humans. Neoplasm Proteins / analysis. Papanicolaou Test. Staining and Labeling / methods. Uterine Cervical Dysplasia /
diagnosis
. Vaginal Smears / methods
MedlinePlus Health Information.
consumer health - Cervical Cancer
.
International Agency for Research on Cancer - Screening Group.
diagnostics - A practical manual on visual screening for cervical neoplasia
.
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.
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[Cites]
Mod Pathol. 2003 Jul;16(7):665-73
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[
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]
(PMID = 16467166.001).
[ISSN]
0021-9746
[Journal-full-title]
Journal of clinical pathology
[ISO-abbreviation]
J. Clin. Pathol.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins
[Other-IDs]
NLM/ PMC1860457
49.
Christian CK, Kwaan MR, Betensky RA, Breen EM, Zinner MJ, Bleday R:
Risk factors for perineal wound complications following abdominoperineal resection.
Dis Colon Rectum
; 2005 Jan;48(1):43-8
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Patients with
anal
cancer
had a higher rate of major complications than those with rectal
cancer or
inflammatory bowel disease.
Minor wound complications were more common in patients with
anal
cancer
and inflammatory bowel disease than those with rectal
cancer
.
When the subset of patients with rectal
cancer
was considered, higher rates of major wounds were associated with increased body mass index, diabetes, and stage.
Patients with
anal
cancer
and inflammatory bowel disease were at higher risk for perineal wound complications than those with rectal
cancer
.
Preoperative radiation and primary closure were not associated with increased complications following abdominoperineal resection for rectal
cancer
.
[MeSH-major]
Abdomen / surgery.
Anus
Neoplasms / surgery. Inflammatory Bowel Diseases / complications. Perineum / injuries. Perineum / surgery. Postoperative Complications
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.
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(PMID = 15690656.001).
[ISSN]
0012-3706
[Journal-full-title]
Diseases of the colon and rectum
[ISO-abbreviation]
Dis. Colon Rectum
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
50.
Johann DJ Jr, Wei BR, Prieto DA, Chan KC, Ye X, Valera VA, Simpson RM, Rudnick PA, Xiao Z, Issaq HJ, Linehan WM, Stein SE, Veenstra TD, Blonder J:
Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma.
Anal Chem
; 2010 Mar 01;82(5):1584-8
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[Title]
Combined blood/tissue analysis for
cancer
biomarker discovery: application to renal
cell
carcinoma
.
A method that relies on subtractive tissue-directed shot-gun proteomics to identify tumor proteins in the blood of a patient newly diagnosed with
cancer
is described.
To avoid analytical and statistical biases caused by physiologic variability of protein expression in the human population, this method was applied on clinical specimens obtained from a single patient diagnosed with nonmetastatic renal
cell
carcinoma
(RCC).
[MeSH-major]
Biomarkers, Tumor / metabolism.
Carcinoma
, Renal
Cell
/ blood. Kidney Neoplasms / blood
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consumer health - Renal cell carcinoma
.
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(PMID = 20121140.001).
[ISSN]
1520-6882
[Journal-full-title]
Analytical chemistry
[ISO-abbreviation]
Anal. Chem.
[Language]
eng
[Grant]
United States / NCI NIH HHS / BC / Z01 BC011023-01; United States / NCI NIH HHS / BC / Z01 BC011089-01; United States / NCI NIH HHS / BC / Z01 BC011028-01; United States / NCI NIH HHS / BC / Z01 BC011038-01; United States / NCI NIH HHS / CO / N01 CO012400; United States / NCI NIH HHS / CA / N01CO12400; United States / NCI NIH HHS / CO / N01-CO-12400
[Publication-type]
Letter; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Other-IDs]
NLM/ NIHMS175878; NLM/ PMC3251958
51.
Cho BC, Ahn JB, Seong J, Roh JK, Kim JH, Chung HC, Sohn JH, Kim NK:
Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in anal squamous cell carcinoma: long-term results in 31 patients.
BMC Cancer
; 2008;8:8
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[Title]
Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in
anal
squamous cell
carcinoma
: long-term results in 31 patients.
BACKGROUND: The objectives of this study were to evaluate long-term results of concurrent chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin and the potential benefit of consolidation chemotherapy in patients with
anal
squamous cell
carcinoma
(ASCC).
CONCLUSION: our study shows that CRT with 5-FU and cisplatin, with or without consolidation chemotherapy, was well tolerated and proved highly encouraging in terms of long-term survival and the preservation of
anal
function in ASCC.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use.
Anus
Neoplasms / drug therapy.
Anus
Neoplasms / radiotherapy.
Carcinoma
,
Squamous Cell
/ drug therapy.
Carcinoma
,
Squamous Cell
/ radiotherapy. Cisplatin / therapeutic use. Fluorouracil / therapeutic use
Genetic Alliance.
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.
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Hazardous Substances Data Bank.
CIS-DIAMINEDICHLOROPLATINUM
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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.
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[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article
[Publication-country]
England
[Chemical-registry-number]
Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
[Other-IDs]
NLM/ PMC2245963
52.
Helpap B, Egevad L:
[Clinical insignificance of prostate cancer: are there morphological findings?].
Urologe A
; 2009 Feb;48(2):170-4
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[Title]
[Clinical insignificance of prostate
cancer
: are there morphological findings?].
[Transliterated title]
Zur klinischen Insignifikanz
des
Prostatakarzinoms: Gibt es morphologische Hinweise?
STUDY DESIGN: More than 1,000 consecutive core needle biopsy specimens of prostate
carcinoma
taken during 1 year (2007) were graded according to the modified Gleason scoring system.
Cancers
with tumor infiltration of <1 mm in one of up to 12 cores and PSA <10 ng/ml mainly had low Gleason scores (6 and 7a), but only 5% of the carcinomas in the studied specimens corresponded to such a parameter.
[MeSH-major]
Biopsy, Needle / methods. Prostate-Specific Antigen / blood. Prostatic Neoplasms / blood. Prostatic Neoplasms /
diagnosis
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[ISSN]
1433-0563
[Journal-full-title]
Der Urologe. Ausg. A
[ISO-abbreviation]
Urologe A
[Language]
ger
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Germany
[Chemical-registry-number]
EC 3.4.21.77 / Prostate-Specific Antigen
53.
Claas C, Wahl J, Orlicky DJ, Karaduman H, Schnölzer M, Kempf T, Zöller M:
The tetraspanin D6.1A and its molecular partners on rat carcinoma cells.
Biochem J
; 2005 Jul 1;389(Pt 1):99-110
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[Title]
The tetraspanin D6.1A and its molecular partners on rat
carcinoma
cells.
In this paper, we summarize our studies performed on the tetraspanin D6.1A/CO-029/TM4SF3 expressed by rat
carcinoma
cells.
[MeSH-minor]
Animals. Antigens, CD / metabolism. Antigens, CD81. Antigens, CD9.
Cell
Line, Tumor. Detergents / pharmacology. Multiprotein Complexes / chemistry. Multiprotein Complexes / metabolism. Pancreatic Neoplasms / metabolism. Protein Binding / drug effects. Rats. Solubility / drug effects. Tetraspanins. Urinary Bladder Neoplasms / metabolism
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[ISSN]
1470-8728
[Journal-full-title]
The Biochemical journal
[ISO-abbreviation]
Biochem. J.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antigens, CD; 0 / Antigens, CD81; 0 / Antigens, CD9; 0 / Cd81 protein, rat; 0 / Detergents; 0 / Membrane Glycoproteins; 0 / Multiprotein Complexes; 0 / Neoplasm Proteins; 0 / Ptgfrn protein, rat; 0 / Tetraspanins; 0 / Tspan8 protein, rat
[Other-IDs]
NLM/ PMC1184542
54.
Jelski W, Mroczko B, Szmitkowski M:
The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of colorectal cancer patients.
Dig Dis Sci
; 2010 Oct;55(10):2953-7
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[Title]
The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of colorectal
cancer
patients.
BACKGROUND: The activity of total alcohol dehydrogenase (ADH) and class I isoenzymes is significantly higher in colorectal
cancer
tissue than in healthy mucosa.
The activity of these enzymes in
cancer
cells is probably reflected in the sera and could thus be helpful for diagnosing colorectal
cancer
.
AIM: The aim of this study was to investigate a potential role of ADH and aldehyde dehydrogenase (ALDH) as tumor markers for colorectal
cancer
.
METHODS: Serum samples were taken from 182 patients with colorectal
cancer
before treatment and from 160 control subjects.
RESULTS: There was significant increase in the activity of ADH I isoenzyme and ADH total in the sera of colorectal
cancer
patients compared to the control.
The sensitivity and specificity of ADH I increased with the stage of the
carcinoma
.
CONCLUSION: The results suggest a potential role for ADH I as marker for colorectal
cancer
.
[MeSH-major]
Alcohol Dehydrogenase / blood. Aldehyde Dehydrogenase / blood. Biomarkers / blood. Colorectal Neoplasms /
diagnosis
. Colorectal Neoplasms / metabolism. Isoenzymes / blood
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[ISSN]
1573-2568
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers; 0 / Isoenzymes; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / Aldehyde Dehydrogenase
55.
Schmidt B, Liebenberg V, Dietrich D, Schlegel T, Kneip C, Seegebarth A, Flemming N, Seemann S, Distler J, Lewin J, Tetzner R, Weickmann S, Wille U, Liloglou T, Raji O, Walshaw M, Fleischhacker M, Witt C, Field JK:
SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates.
BMC Cancer
; 2010;10:600
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[Title]
SHOX2 DNA methylation is a biomarker for
the diagnosis
of lung
cancer
based on bronchial aspirates.
BACKGROUND: This study aimed to show that SHOX2 DNA methylation is a tumor marker in patients with suspected lung
cancer
by using bronchial fluid aspirated during bronchoscopy.
Such a biomarker would be clinically valuable, especially when, following the first bronchoscopy, a final
diagnosis
cannot be established by histology or cytology.
CONCLUSIONS: Hypermethylation of SHOX2 in bronchial aspirates appears to be a clinically useful tumor marker for identifying subjects with lung
carcinoma
, especially if histological and cytological findings after bronchoscopy are ambiguous.
[MeSH-minor]
Adult. Aged. Bronchoscopy / methods.
Carcinoma
/ metabolism. Case-Control Studies. DNA Methylation. False Positive Reactions. Female. Humans. Male. Middle Aged. Nucleic Acid Hybridization. Sensitivity and Specificity
Genetic Alliance.
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MedlinePlus Health Information.
consumer health - Lung Cancer
.
The Lens.
Cited by Patents in
.
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(PMID = 21047392.001).
[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / SHOX2 protein, human
[Other-IDs]
NLM/ PMC2988753
56.
Fox PA, Seet JE, Stebbing J, Francis N, Barton SE, Strauss S, Allen-Mersh TG, Gazzard BG, Bower M:
The value of anal cytology and human papillomavirus typing in the detection of anal intraepithelial neoplasia: a review of cases from an anoscopy clinic.
Sex Transm Infect
; 2005 Apr;81(2):142-6
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[Title]
The value of
anal
cytology and human papillomavirus typing in the detection of
anal
intraepithelial neoplasia: a review of cases from an anoscopy clinic.
BACKGROUND: Previous studies have reached differing conclusions about the utility of
anal
cytology as a screening tool for
anal
intraepithelial neoplasia (AIN).
Comparison was made between results of
anal
cytology using the sampling method of Palefsky, and histological findings of biopsies taken from abnormal areas seen on high resolution anoscopic examination of the
anal
canal.
At screening of 34 asymptomatic men, 83% had
anal
cytological dysplasia and 78% had AIN.
CONCLUSION:
Anal
cytology by the Palefsky method is simple to undertake, has a sensitivity and specificity comparable with cervical cytology, and can therefore be used as the basis of a pilot screening project in centres with large cohorts of HIV positive homosexual men who have a high risk of developing
anal carcinoma
.
[MeSH-major]
Anus
Neoplasms / pathology. Bisexuality.
Carcinoma
in Situ / pathology. Homosexuality, Male. Papillomavirus Infections / pathology
MedlinePlus Health Information.
consumer health - Anal Cancer
.
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consumer health - Gay, Lesbian, Bisexual, and Transgender Health
.
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[ISSN]
1368-4973
[Journal-full-title]
Sexually transmitted infections
[ISO-abbreviation]
Sex Transm Infect
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC1764665
57.
Johnson NM, Qian G, Xu L, Tietze D, Marroquin-Cardona A, Robinson A, Rodriguez M, Kaufman L, Cunningham K, Wittmer J, Guerra F, Donnelly KC, Williams JH, Wang JS, Phillips TD:
Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma.
Sci Total Environ
; 2010 Nov 1;408(23):6027-31
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[Title]
Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular
carcinoma
.
The incidence of hepatocellular
carcinoma
(HCC) is significantly elevated in a Hispanic community in Bexar County, Texas.
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.
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[Copyright]
Copyright © 2010 Elsevier B.V. All rights reserved.
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J Clin Gastroenterol. 2002 Sep;35(3):266-9
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12192205.001
]
(PMID = 20870273.001).
[ISSN]
1879-1026
[Journal-full-title]
The Science of the total environment
[ISO-abbreviation]
Sci. Total Environ.
[Language]
ENG
[Grant]
United States / NIEHS NIH HHS / ES / P30 ES009106; United States / NIEHS NIH HHS / ES / ES09106
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Aflatoxins; 0 / Biomarkers; 0 / Environmental Pollutants; 0 / Polycyclic Hydrocarbons, Aromatic; 0 / Pyrenes; 0 / aflatoxin B1-lysine adduct; 5315-79-7 / 1-hydroxypyrene; 9N2N2Y55MH / Aflatoxin B1; AYI8EX34EU / Creatinine; K3Z4F929H6 / Lysine
[Other-IDs]
NLM/ NIHMS236527; NLM/ PMC2993492
58.
Lu ZJ, Song QF, Jiang SS, Song Q, Wang W, Zhang GH, Kan B, Chen LJ, Yang JL, Luo F, Qian ZY, Wei YQ, Gou LT:
Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen.
BMC Cancer
; 2009;9:16
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[Title]
Identification of ATP synthase beta subunit (ATPB) on
the cell
surface as a non-small
cell
lung
cancer
(NSCLC) associated antigen.
BACKGROUND: Antibody-based immunotherapy has achieved some success for
cancer
.
It is essential to identify more immunogenic antigens (especially cellular membrane markers) for tumor
diagnosis
and therapy.
METHODS: The membrane proteins of lung adenocarcinoma
cell
line A549 were used to immunize the BALB/c mice.
MTT
cell
proliferation assay was carried out to evaluate the inhibitory effect of McAb4E7 on A549 cells.
Flow cytometric assay, immunohistochemistry, western blot and proteomic technologies based on 2-
DE
and mass spectrometry were employed to detect and identify the corresponding antigen of McAb4E7.
Furthermore, immunohistochemistry showed that the antigen of McAb4E7 mainly aberrantly expressed in tumor cellular membrane in non-small
cell
lung
cancer
(NSCLC), but not in small
cell
lung
cancer
(SCLC).
The rate of ectopic expressed ATPB in the cellular membrane in lung adenocarcinoma,
squamous
carcinoma
and their adjacent nontumourous lung tissues was 71.88%, 66.67% and 25.81% respectively.
CONCLUSION: In the present study, we identified that the ectopic ATPB in tumor cellular membrane was the non-small
cell
lung
cancer
(NSCLC) associated antigen.
[MeSH-major]
Biomarkers, Tumor / analysis.
Carcinoma
, Non-Small-
Cell
Lung / enzymology. Lung Neoplasms / enzymology. Mitochondrial Proton-Translocating ATPases / analysis
Genetic Alliance.
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.
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consumer health - Lung Cancer
.
NCI CPTAC Assay Portal.
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[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Biomarkers, Tumor; EC 3.6.3.- / Mitochondrial Proton-Translocating ATPases; EC 3.6.3.14 / ATP5B protein, human
[Other-IDs]
NLM/ PMC2654462
59.
Irons R, Tsuji PA, Carlson BA, Ouyang P, Yoo MH, Xu XM, Hatfield DL, Gladyshev VN, Davis CD:
Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells.
Cancer Prev Res (Phila)
; 2010 May;3(5):630-9
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[Title]
Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon
cancer
cells.
Selenium has
cancer
-preventive activity that is mediated, in part, through selenoproteins.
The role of the 15-kDa selenoprotein (Sep15) in colon
cancer
was assessed by preparing and using mouse colon CT26 cells stably transfected with short hairpin RNA constructs targeting Sep15.
The highest-scored biological functions were
cancer
and cellular growth and proliferation.
Consistent with these observations, subsequent analyses revealed a G(2)-
M cell
cycle arrest in cells with targeted downregulation of Sep15.
In contrast to CT26 cells, Sep15-targeted downregulation in Lewis lung
carcinoma
(LLC1) cells did not affect anchorage-dependent or anchorage-independent
cell
growth.
These data suggest tissue specificity in
the cancer
-protective effects of Sep15 downregulation, which are mediated, at least in part, by influencing
the cell
cycle.
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Cell. 2000 Jan 7;100(1):57-70
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11012661.001
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(PMID = 20388823.001).
[ISSN]
1940-6215
[Journal-full-title]
Cancer prevention research (Philadelphia, Pa.)
[ISO-abbreviation]
Cancer Prev Res (Phila)
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA080946; United States / Intramural NIH HHS / / Z99 CA999999; United States / NCI NIH HHS / CA / CA080946
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Chemical-registry-number]
0 / RNA, Small Interfering; 0 / Selenoproteins; 0 / Sep15 protein, mouse
[Other-IDs]
NLM/ NIHMS184300; NLM/ PMC2865577
60.
Polton G:
Examining the risk of anal sac gland carcinoma in cocker spaniels.
J Small Anim Pract
; 2006 Sep;47(9):557
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[Title]
Examining the risk of
anal
sac gland
carcinoma
in cocker spaniels.
[MeSH-major]
Anal
Gland Neoplasms / genetics.
Anal
Sacs. Dog Diseases / genetics
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(PMID = 16961479.001).
[ISSN]
0022-4510
[Journal-full-title]
The Journal of small animal practice
[ISO-abbreviation]
J Small Anim Pract
[Language]
eng
[Publication-type]
Letter
[Publication-country]
England
61.
Kiran RP, Pokala N, Rottoli M, Fazio VW:
Is survival reduced for patients with anal cancer requiring surgery after failure of radiation? Analysis from a population study over two decades.
Am Surg
; 2009 Feb;75(2):163-8
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[Title]
Is survival reduced for patients with
anal
cancer
requiring surgery after failure of radiation? Analysis from a population study over two decades.
Chemoradiotherapy is the standard treatment for
anal
cancer
.
From a prospective population-based database on radiation and surgical therapy, we compare outcomes for patients with
anal
cancer
undergoing rectal resection after radiation with patients undergoing radiation alone.
Patients undergoing surgical resection of the rectum after initial radiation (SRT) for
squamous cell
carcinoma
of the
anus
,
anal
canal, cloacogenic zone, and overlapping lesions of the rectum and
anal
canal from 1983 to 2002 were identified from the Surveillance, Epidemiology and End Results database.
[MeSH-major]
Anus
Neoplasms / mortality.
Anus
Neoplasms / surgery.
Carcinoma
,
Squamous Cell
/ mortality.
Carcinoma
,
Squamous Cell
/ surgery
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consumer health - Anal Cancer
.
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(PMID = 19280811.001).
[ISSN]
0003-1348
[Journal-full-title]
The American surgeon
[ISO-abbreviation]
Am Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
62.
Mehrotra R, Gupta A, Singh M, Ibrahim R:
Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.
Mol Cancer
; 2006;5:11
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Cytological study of oral cells is a non-aggressive technique that is well accepted by the patient, and is therefore an attractive option for the early
diagnosis of
oral
cancer
, including epithelial atypia and
squamous cell
carcinoma
.
Lately it has re-emerged due to improved methods and it's application in oral precancer and
cancer
as a diagnostic and predictive method as well as for monitoring patients.
MedlinePlus Health Information.
consumer health - Oral Cancer
.
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[RetractionIn]
Mol Cancer. 2012;11:57
[
22905981.001
]
(PMID = 16556320.001).
[ISSN]
1476-4598
[Journal-full-title]
Molecular cancer
[ISO-abbreviation]
Mol. Cancer
[Language]
eng
[Publication-type]
Journal Article; Retracted Publication; Review
[Publication-country]
England
[Number-of-references]
68
[Other-IDs]
NLM/ PMC1448188
63.
Yang SP, Lee HJ, Su Y:
Molecular cloning and structural characterization of the functional human thymosin beta4 gene.
Mol Cell Biochem
; 2005 Apr;272(1-2):97-105
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Expression of the chloramphenicol acetyltransferase (CAT) reporter constructs directed by various parts of the 5'-flanking region of this gene was evaluated by transient transfection assays using human colorectal
carcinoma
SW480 cells as hosts.
Taken together, our data provide crucial information for further dissection of the molecular mechanism(s) underlying aberrant expression of the Tbeta4 gene during malignant progression of human
cancers
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
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[ISSN]
0300-8177
[Journal-full-title]
Molecular and cellular biochemistry
[ISO-abbreviation]
Mol. Cell. Biochem.
[Language]
eng
[Databank-accession-numbers]
GENBANK/ AJ295158
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Codon, Initiator; 549LM7U24W / thymosin beta(4); 61512-21-8 / Thymosin
64.
Mannello F, Tonti GA, Canestrari F:
Nutrients and nipple aspirate fluid composition: the breast microenvironment regulates protein expression and cancer aetiology.
Genes Nutr
; 2008 Jul;3(2):77-85
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[Title]
Nutrients and nipple aspirate fluid composition: the breast microenvironment regulates protein expression and
cancer
aetiology.
The aetiology of breast
cancer
is complex and multifactorial, and may include diet and xenobiotic compounds.
A wide variation in biomolecular and hormonal composition of NAFs collected from healthy and breast
cancer
patient may be due to genetic and nutritional factors; however, micro- and macro-nutrients may influence the secretory status of these women, thus NAF composition and risk of breast
carcinoma
.
The aim of this overview is to highlight the detrimental/beneficial role that diet-related compounds in nipple aspirate fluid can have in breast
cancer
risk.
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[ISSN]
1555-8932
[Journal-full-title]
Genes & nutrition
[ISO-abbreviation]
Genes Nutr
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Germany
[Other-IDs]
NLM/ PMC2467451
65.
Dhir AA, Sawant S, Dikshit RP, Parikh P, Srivastava S, Badwe R, Rajadhyaksha S, Dinshaw KA:
Spectrum of HIV/AIDS related cancers in India.
Cancer Causes Control
; 2008 Mar;19(2):147-53
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[Title]
Spectrum of HIV/AIDS related
cancers
in India.
OBJECTIVE: To study
the cancer
pattern among HIV positive
cancer
cases.
METHOD: The study group included patients registered in the HIV
Cancer
clinic at the Tata Memorial Hospital (TMH), Mumbai, which is the largest tertiary referral
cancer
center in India.
We used the gender and age-specific proportions of each
cancer
site of the year 2002 that was recorded in the Hospital
Cancer
Registry to estimate an expected number of various
cancer
sites among HIV positive
cancer
patients during the period 2001-2005.
The observed number of site-specific
cancer
cases was divided by the expected number to obtain proportional incidence ratio (PIR).
In males, PIR was increased for
anal
cancer
(PIR = 10.3, 95%CI 4.30-24.83), Hodgkin's disease, testicular
cancer
, colon
cancer
, and few head and neck
cancer
sites.
Among females, the PIRs for cervical
cancer
(PIR = 4.1, 95%CI 2.90-5.75), vaginal
cancer
(PIR = 7.7, 95%CI 2.48-23.85), and
anal
cancer
(PIR = 6.5, 95%CI 0.91-45.88) were increased.
CONCLUSIONS: The absence of Kaposi's sarcoma and increased PIRs for certain non-AIDS defining
cancers
among HIV infected
cancer
cases indicates a different spectrum of HIV associated malignancies in this region.
The raised PIR for cervical
cancer
emphasizes the urgent need for screening programs for cervical
cancer
among HIV infected individuals in India.
Genetic Alliance.
consumer health - AIDS-HIV
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Genetic Alliance.
consumer health - HIV
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MedlinePlus Health Information.
consumer health - Cancer in Children
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MedlinePlus Health Information.
consumer health - HIV/AIDS
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MedlinePlus Health Information.
consumer health - HIV/AIDS in Women
.
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(PMID = 17992576.001).
[ISSN]
0957-5243
[Journal-full-title]
Cancer causes & control : CCC
[ISO-abbreviation]
Cancer Causes Control
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Netherlands
66.
Ljubojević S, Lipozencić J, Skerlev M, Zele-Starcević L, Ljubojević N, Babić D, Grubisić G, Jukić S:
[Diagnostic-therapeutic guidelines for men whose partners have HPV genital infection].
Lijec Vjesn
; 2009 Sep-Oct;131(9-10):269-74
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HPV infections are connected with different diseases such as benign warts, condylomata acuminata, malignant cervical, vulvar, vaginal, penile and
anal carcinoma
.
Peniscopy with HPV detection is a specific diagnostic method for
diagnosis of
subclinical HPV genital infection in asymptomatic men.
Early
diagnosis
and treatment of HPV infections in men is of potential benefit because their eradication can reduce the viral reservoir and as the result of that the incidence of CIN,
carcinoma
in situ and invasive cervical
carcinoma
can be reduced.
For the correct
diagnosis
and for choosing the adequate therapeutical technique, we suggest diagnostic-therapeutic guidelines for HPV genital infection in men.
[MeSH-major]
Papillomavirus Infections /
diagnosis
. Papillomavirus Infections / therapy. Penile Diseases /
diagnosis
. Penile Diseases / therapy
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(PMID = 20030291.001).
[ISSN]
0024-3477
[Journal-full-title]
Lijec̆nic̆ki vjesnik
[ISO-abbreviation]
Lijec Vjesn
[Language]
hrv
[Publication-type]
English Abstract; Journal Article; Review
[Publication-country]
Croatia
[Number-of-references]
41
67.
Meyer J, Willett C, Czito B:
Current and emerging treatment strategies for anal cancer.
Curr Oncol Rep
; 2010 May;12(3):168-74
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[Title]
Current and emerging treatment strategies for
anal
cancer
.
Concurrent radiotherapy and chemotherapy (5-fluorouracil and mitomycin-C) is established as a sphincter-preserving treatment for
squamous cell
carcinoma
of the
anal
canal.
This review discusses the evolution of therapy for
anal
cancer
, from early clinical trials establishing the current standard to more recent studies evaluating cisplatin, capecitabine, oxaliplatin, and cetuximab.
[MeSH-major]
Antineoplastic Agents / therapeutic use.
Anus
Neoplasms / drug therapy.
Anus
Neoplasms / radiotherapy
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[Cites]
Lancet. 1996 Oct 19;348(9034):1049-54
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[Cites]
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[
8823332.001
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[Cites]
J Clin Oncol. 2007 Oct 10;25(29):4581-6
[
17925552.001
]
(PMID = 20425076.001).
[ISSN]
1534-6269
[Journal-full-title]
Current oncology reports
[ISO-abbreviation]
Curr Oncol Rep
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents
[Number-of-references]
30
68.
Pascual I, Alvarez-Gallego M, Herreros MD, Garcia-Olmo D, García-Fernández E:
Metastasis in anal mucosa from bladder cancer.
Tech Coloproctol
; 2006 Oct;10(3):255
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[Title]
Metastasis in
anal
mucosa from bladder
cancer
.
[MeSH-major]
Anus
Neoplasms / secondary.
Carcinoma
, Papillary / secondary. Urinary Bladder Neoplasms / pathology
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(PMID = 17086663.001).
[ISSN]
1123-6337
[Journal-full-title]
Techniques in coloproctology
[ISO-abbreviation]
Tech Coloproctol
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
Italy
69.
Zuo ZG, Song HY, Li J, Xu C, Zhou ZH, Ni SC, Chen SQ:
[Clinical application of intersphincteric resection in the anal-preserving operation for ultra-low rectal carcinoma].
Zhonghua Zhong Liu Za Zhi
; 2009 Dec;31(12):941-4
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[Title]
[Clinical application of intersphincteric resection in the
anal
-preserving operation for ultra-low rectal
carcinoma
].
OBJECTIVE: To investigate the clinical application of intersphincter resection (ISR) combined with total mesorectal excision (TME) and colon-
anal
anastomosis in the treatment for ultra-low rectal
carcinoma
.
METHODS: To review and analyze retrospectively the data of 34 patients with ultra-low rectal
carcinoma
(without external
anal
sphincter involvement) who received treatment of ISR, TME and colon-
anal
anastomosis.
Reconstruction of digestive tract was done by manual colon-
anal
anastomosis.
The average distance from distal excised
margin
to the tumor was 2.3 (1.8 - 3.2) cm among 34 patients.
The pathological types were as follows: 28 cases of adenocarcinoma (11 were well differentiated, 17 moderately differentiated), 1 case of papillary
carcinoma
and 5 cases of villous adenoma with malignant change.
CONCLUSION: With strictly grasping indications, radical resection can be attained and
anal
sphincter preserved by ISR combined with TME and colon-
anal
anastomosis.
[MeSH-major]
Adenocarcinoma / surgery.
Anal
Canal / surgery. Rectal Neoplasms / surgery. Rectum / surgery
[MeSH-minor]
Adenoma, Villous / pathology. Adenoma, Villous / surgery. Adult. Aged. Aged, 80 and over. Anastomosis, Surgical.
Carcinoma
, Papillary / pathology.
Carcinoma
, Papillary / surgery. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Surgical Wound Dehiscence / etiology
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(PMID = 20193339.001).
[ISSN]
0253-3766
[Journal-full-title]
Zhonghua zhong liu za zhi [Chinese journal of oncology]
[ISO-abbreviation]
Zhonghua Zhong Liu Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Evaluation Studies; Journal Article
[Publication-country]
China
70.
Parry NM:
Anal sac gland carcinoma in a cat.
Vet Pathol
; 2006 Nov;43(6):1008-9
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[Title]
Anal
sac gland
carcinoma
in a cat.
A
perianal
mass in a 15-year-old domestic shorthair cat with a history of a firm, painful swelling in the left ventrolateral
perianal
region was surgically excised and submitted for light microscopic evaluation.
Acinar lumina sometimes contained eosinophilic proteinaceous material
or cell
debris.
These microscopic features are consistent with
anal
sac gland
carcinoma
.
[MeSH-major]
Anal
Gland Neoplasms / pathology.
Anal
Sacs / pathology.
Carcinoma
/ veterinary. Cat Diseases / pathology
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(PMID = 17099161.001).
[ISSN]
0300-9858
[Journal-full-title]
Veterinary pathology
[ISO-abbreviation]
Vet. Pathol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
71.
Lin GL, Qiu HZ, Xiao Y, Wu B, Meng WC:
[Transanal endoscopic microsurgery for rectal intraepithelial neoplasia and early rectal carcinoma].
Zhonghua Wei Chang Wai Ke Za Zhi
; 2008 Jan;11(1):39-43
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[Title]
[Transanal endoscopic microsurgery for rectal intraepithelial neoplasia and early rectal
carcinoma
].
OBJECTIVE: To investigate the clinical value of transanal endoscopic microsurgery (TEM) for rectal intraepithelial neoplasia (IN) and early rectal
carcinoma
.
The pre-operative
diagnosis
by biopsy and endoanal ultrasonography (EUS): rectal low-grade IN in 8 cases, high-grade IN in 4 and early rectal
carcinoma
in 3.
The average distance of tumors from the
anal
verge was 7.2(4-15) cm.
The post-operative pathological
diagnosis
: rectal low-grade IN in 5 cases, high-grade IN in 6, early submucous invasive
carcinoma
(pT(1)) in 2, advanced
carcinoma
(pT(2)) in 2.
CONCLUSION: TEM is an ideal minimally invasive procedure for the treatment of rectal IN and early rectal
carcinoma
, with excellent exposure and accurate excision, providing a high-quality tumor specimen for pathological staging.
[MeSH-major]
Anal
Canal / surgery. Microsurgery. Rectal Neoplasms / surgery. Rectum / surgery
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(PMID = 18197492.001).
[ISSN]
1671-0274
[Journal-full-title]
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
[ISO-abbreviation]
Zhonghua Wei Chang Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Evaluation Studies; Journal Article
[Publication-country]
China
72.
Safioleas MC, Moulakakis KG, Stamatakos M, Kountouras J, Lygidakis NJ:
Local recurrence following curative low anterior resection for rectal carcinoma.
Hepatogastroenterology
; 2005 Jan-Feb;52(61):94-6
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[Title]
Local recurrence following curative low anterior resection for rectal
carcinoma
.
BACKGROUND/AIMS: Local recurrence is a formidable problem after potentially curative resection for rectal
cancer
.
We attempted to identify possible factors affecting the frequency of local recurrence, focusing on the clearance of the tumor and
the margin
of resection.
METHODOLOGY: The clinical cohort consisted of 66 patients suffering from rectal
carcinoma
.
RESULTS: Analysis by distance of the tumor from the
anal
verge revealed that 5 out of 33 patients (15.15%) from the upper rectal group and 7 out of 19 patients (36.8%) from the mid rectal group developed local recurrences (36.8% vs. 15.15% P=0.0369).
[MeSH-major]
Carcinoma
/ mortality.
Carcinoma
/ surgery. Neoplasm Recurrence, Local / etiology. Neoplasm Recurrence, Local / mortality. Rectal Neoplasms / mortality. Rectal Neoplasms / surgery
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(PMID = 15783003.001).
[ISSN]
0172-6390
[Journal-full-title]
Hepato-gastroenterology
[ISO-abbreviation]
Hepatogastroenterology
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
73.
Kreuter A, Brockmeyer NH, Altmeyer P, Wieland U, German Competence Network HIV/AIDS:
Anal intraepithelial neoplasia in HIV infection.
J Dtsch Dermatol Ges
; 2008 Nov;6(11):925-34
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[Title]
Anal
intraepithelial neoplasia in HIV infection.
In HIV-infected men who have sex with men (MSM),
anal
HPV prevalence is more than 90% and infections with multiple HPV types are common.
Anal
intraepithelial neoplasia (AIN) is a potential precursor lesion
of squamous cell
carcinoma
of the
anus
.
As AIN and CIN share distinct biological similar-ities, AIN screenings analogous to Pap smear programs for CIN have been recommended in high-risk populations to reduce the incidence of
anal carcinoma
.
These screenings include cytological analysis followed by high resolution anoscopy in case of
anal
dysplasia.
[MeSH-major]
Anus
Neoplasms /
diagnosis
.
Anus
Neoplasms / therapy. HIV Infections /
diagnosis
. HIV Infections / therapy. Papillomavirus Infections /
diagnosis
. Papillomavirus Infections / therapy.
Skin
Neoplasms /
diagnosis
.
Skin
Neoplasms / therapy
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(PMID = 18410393.001).
[ISSN]
1610-0387
[Journal-full-title]
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
[ISO-abbreviation]
J Dtsch Dermatol Ges
[Language]
eng; ger
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
Germany
[Number-of-references]
46
74.
Han SL, Zeng QQ, Shen X, Zheng XF, Guo SC, Yan JY:
The indication and surgical results of local excision following radiotherapy for low rectal cancer.
Colorectal Dis
; 2010 Nov;12(11):1094-8
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[Title]
The indication and surgical results of local excision following radiotherapy for low rectal
cancer
.
AIM: Radical surgery of rectal
cancer
is associated with significant morbidity, and some patients with low-lying lesions must accept a permanent colostomy.
The objective of this study was to evaluate the outcome of local excision followed by adjuvant radiotherapy for rectal
cancer
for curative purposes.
METHOD: One hundred and seven patients with rectal
carcinoma
performed with local excision were analysed retrospectively.
RESULTS: The procedures of local excision were trans-
anal
resection in 83 patients, trans-sacral resection in 16, trans-sphincteric local resection in five, and trans-vaginal resection in three.
CONCLUSIONS: Local excision followed adjuvant radiotherapy is an alternative and feasible technique for small T1 rectal
cancer
in selected cases.
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[Copyright]
© 2010 The Authors. Colorectal Disease © 2010 The Association of Coloproctology of Great Britain and Ireland.
(PMID = 19863609.001).
[ISSN]
1463-1318
[Journal-full-title]
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
[ISO-abbreviation]
Colorectal Dis
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
75.
Borel M, Degoul F, Communal Y, Mounetou E, Bouchon B, C-Gaudreault R, Madelmont JC, Miot-Noirault E:
N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a mi