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1. Ortholan C, François E, Gérard JP: [Chemoradiotherapy and anal canal cancer]. Bull Cancer; 2005 Dec;92(12):1039-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Chemoradiotherapy and anal canal cancer].
  • [Transliterated title] Chimioradiothérapie des cancers du canal anal.
  • Local control and sphincter preservation are the two challenges of anal canal cancer treatment.
  • Indications of chemoradiotherapy are locally advanced tumor T2 > or = 4 cm, T3-4 or N1-3 but the best modalities of combined treatment are still under debate.
  • This article is a review of past randomised trials, phases II and retrospective study on radiochemotherapy of anal canal carcinoma.
  • [MeSH-major] Anus Neoplasms / drug therapy. Anus Neoplasms / radiotherapy

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  • (PMID = 16396750.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Pyrimidines; 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
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2. Nadal SR, Horta SH, Calore EE, Nadal LR, Manzione CR: [How far into the anal canal should the brush be introduced for more efficient cytological evaluation?]. Rev Assoc Med Bras (1992); 2009 Nov-Dec;55(6):749-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [How far into the anal canal should the brush be introduced for more efficient cytological evaluation?].
  • [Transliterated title] Quanto a escova deve ser introduzida no canal anal para avaliação citológica mais eficaz?
  • Possibly this is because there is no standard for how far the brush should be introduced into the anal canal.
  • The aim was to evaluate whether the sampling site has an influence on the results of anal Pap smears.
  • METHOD: We obtained specimens with brushes introduced 4 cm into the anal canal in 114 patients (Group A) and 2 cm in 94 patients (Group B), before anorectal examination.
  • RESULTS: In Group A, 39 patients had anal canal condylomas and the cytology was positive in 29 of them (74.3%).
  • We also observed cytological alterations in 30 of 75 patients (40%) without clinical lesions in the anal canal.
  • CONCLUSION. Specimens collected by inserting the brush deeper into the anal canal improved the efficiency of anal Pap smears.
  • [MeSH-major] Anal Canal / pathology. Condylomata Acuminata / pathology. Papillomavirus Infections / pathology. Specimen Handling / standards

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  • (PMID = 20191232.001).
  • [ISSN] 0104-4230
  • [Journal-full-title] Revista da Associação Médica Brasileira (1992)
  • [ISO-abbreviation] Rev Assoc Med Bras (1992)
  • [Language] por
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Brazil
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3. Antunes MI, Bujor L, Grillo IM: Anal canal plasmacytoma-An uncommon presentation site. Rep Pract Oncol Radiother; 2010;16(1):36-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal plasmacytoma-An uncommon presentation site.
  • The lower gastrointestinal EMP represents less than 5% of all cases, and location in the anal canal is exceedingly rare.
  • AIM: We present an exceedingly rare case of anal canal plasmacytoma, aiming to achieve a better understanding of this rare entity.
  • METHODS: We report a case of a 61-year-old man with a bulky mass in the anal canal.
  • The lesion measured about 6 cm and invaded in all layers of the anal canal wall.
  • There was no evidence of disease in other locations and these features were consistent with the diagnosis of an extra-osseous plasmacytoma.

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  • (PMID = 24376953.001).
  • [ISSN] 1507-1367
  • [Journal-full-title] Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology
  • [ISO-abbreviation] Rep Pract Oncol Radiother
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC3863234
  • [Keywords] NOTNLM ; Extramedullary plasmacytoma / Radiotherapy
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4. Cummings BJ: Current management of anal canal cancer. Semin Oncol; 2005 Dec;32(6 Suppl 9):S123-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current management of anal canal cancer.
  • Combined-modality therapy consisting of radiation therapy and 5-fluorouracil plus mitomycin remains the standard treatment for localized anal canal cancer, permitting preservation of organ function and achieving high response and survival rates.
  • [MeSH-major] Anus Neoplasms / drug therapy. Anus Neoplasms / radiotherapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Humans. Neoplasm Staging. Randomized Controlled Trials as Topic

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  • (PMID = 16399449.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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5. Kumar GK, Chandra SS, Krishnan R: Local excision inadequate in the treatment of anal canal leiomyosarcoma. Saudi J Gastroenterol; 2010 Jul-Sep;16(3):226-7
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  • [Title] Local excision inadequate in the treatment of anal canal leiomyosarcoma.
  • Leiomyosarcoma of the anal canal is an uncommon neoplasm of the gastrointestinal tract.
  • We report a 45-year-old lady with anal canal leiomyosarcoma.
  • In the setting of a recurrent tumor with high-grade histological appearance, local excision would be deemed unsafe.
  • [MeSH-major] Anal Canal / surgery. Anus Neoplasms / surgery. Leiomyosarcoma / surgery
  • [MeSH-minor] Biopsy. Female. Humans. Middle Aged. Neoplasm Recurrence, Local / pathology. Tomography, X-Ray Computed

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  • (PMID = 20616423.001).
  • [ISSN] 1998-4049
  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • [ISO-abbreviation] Saudi J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
  • [Other-IDs] NLM/ PMC3003215
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6. Sato H, Koh PK, Bartolo DC: Management of anal canal cancer. Dis Colon Rectum; 2005 Jun;48(6):1301-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of anal canal cancer.
  • PURPOSE: Chemoradiotherapy has replaced radical surgery as the initial treatment of choice for anal canal cancer.
  • The roles of these therapeutic modalities are discussed and recommendations on management of anal canal cancer are made based on currently available evidence.
  • METHODS: Literature on management of anal canal cancer from January 1970 to July 2003 obtained via MEDLINE was reviewed.
  • Reports on anal margin cancers were excluded.
  • RESULTS: Randomized, prospective, Phase 3 trials in Europe and the United States showed that chemoradiotherapy with 5-fluorouracil and mitomycin C was superior in local control, colostomy-free rate, progression-free survival, and cancer-specific survival compared with radiation alone.
  • [MeSH-major] Anus Neoplasms / therapy
  • [MeSH-minor] Brachytherapy. Chemotherapy, Adjuvant. Digestive System Surgical Procedures. Dose Fractionation. Humans. Lymphatic Metastasis. Neoplasm Staging. Radiotherapy, High-Energy. Survival Rate

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  • (PMID = 15793642.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 116
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7. Lim JH, Lee MH, Lee MJ, Kim CS, Lee JS, Choi SJ, Yi HG: Plasmablastic lymphoma in the anal canal. Cancer Res Treat; 2009 Sep;41(3):182-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plasmablastic lymphoma in the anal canal.
  • Here, we describe a very rare case of PBL in the anal canal of a 40-year-old woman with human immunodeficiency virus infection.
  • The malignant cells were positive for Epstein-Barr virus and human herpes virus 8.

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  • (PMID = 19809569.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2757665
  • [Keywords] NOTNLM ; Epstein-Bar virus / HIV / Plasmablastic lymphoma
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8. Moreau MV, Tournier-Rangeard L, Kaminsky MC, Peiffert D: [Curative salvage treatment of mediastinal and pleuropulmonar metastatis from anal canal cancer]. Cancer Radiother; 2009 Jul;13(4):329-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Curative salvage treatment of mediastinal and pleuropulmonar metastatis from anal canal cancer].
  • [Transliterated title] Chimioradiothérapie de rattrapage pour métastases médiastinales et pleuropulmonaires d'un cancer du canal anal.
  • This case report presents a 57 years-old woman treated for a squamous cell carcinoma of the anal canal by radiochemotherapy and brachytherapy.
  • This observation is interesting for its curative treatment in metastatic cancer of the anal canal.
  • It also illustrates the radiosensibility of anal canal cancers, including metastatic situations, and raises the contribution of PET-scanner to evaluate the response to treatment and detect a recurrence.
  • [MeSH-major] Anus Neoplasms. Carcinoma, Squamous Cell / secondary. Mediastinal Neoplasms / secondary. Pleural Neoplasms / secondary. Salvage Therapy / methods

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  • (PMID = 19467897.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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9. Crowley C, Winship AZ, Hawkins MA, Morris SL, Leslie MD: Size does matter: can we reduce the radiotherapy field size for selected cases of anal canal cancer undergoing chemoradiation? Clin Oncol (R Coll Radiol); 2009 Jun;21(5):376-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Size does matter: can we reduce the radiotherapy field size for selected cases of anal canal cancer undergoing chemoradiation?
  • AIMS: Chemoradiation is the standard of care for the treatment of anal canal cancer, with surgery reserved for salvage.
  • MATERIALS AND METHODS: Between August 1998 and August 2004, 30 patients with biopsy-proven squamous cell anal canal cancer were treated with chemoradiation using one phase of treatment throughout.
  • The median age at diagnosis was 65 years (range 41-84).
  • CONCLUSIONS: This single-centre retrospective study supports the treatment for selected cases of anal canal cancer with smaller than standard radiation fields, avoiding prophylactic inguinal nodal irradiation.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Lymphatic Irradiation. Radiation Injuries / prevention & control
  • [MeSH-minor] Aged. Aged, 80 and over. Combined Modality Therapy / adverse effects. Female. Humans. Inguinal Canal. Male. Middle Aged. Patient Compliance. Pelvis. Radiation Dosage. Retrospective Studies. Survival Analysis

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  • (PMID = 19282157.001).
  • [ISSN] 0936-6555
  • [Journal-full-title] Clinical oncology (Royal College of Radiologists (Great Britain))
  • [ISO-abbreviation] Clin Oncol (R Coll Radiol)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Czito BG, Willett CG: Current management of anal canal cancer. Curr Oncol Rep; 2009 May;11(3):186-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current management of anal canal cancer.
  • Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence.
  • At present, RT with 5-FU and mitomycin is the standard of care for anal cancer patients.
  • [MeSH-major] Anus Neoplasms / drug therapy. Anus Neoplasms / radiotherapy

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  • (PMID = 19336010.001).
  • [ISSN] 1534-6269
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; U3P01618RT / Fluorouracil
  • [Number-of-references] 24
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11. Trautmann TG, Zuger JH: Positron Emission Tomography for pretreatment staging and posttreatment evaluation in cancer of the anal canal. Mol Imaging Biol; 2005 Jul-Aug;7(4):309-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Positron Emission Tomography for pretreatment staging and posttreatment evaluation in cancer of the anal canal.
  • PURPOSE: In recent years, combined modality therapy (CMT) with chemotherapy and radiation has replaced surgery as the preferred treatment for cancer of the anal canal.
  • PATIENTS AND METHODS: From September 1999 to August 2002, 21 patients with cancer of the anal canal were studied prospectively.
  • CONCLUSIONS: FDG-PET, in conjunction with CT scanning, provides additional staging information in cancer of the anal canal.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / diagnosis. Anus Neoplasms / pathology. Positron-Emission Tomography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Female. Humans. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16028002.001).
  • [ISSN] 1536-1632
  • [Journal-full-title] Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • [ISO-abbreviation] Mol Imaging Biol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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12. Miyamoto S, Maeda Y, Hishima T, Sasaki T: [Case of higher efficacy by chemoradiotherapy for anal canal cancer from left cervix metastases to lymph nodes]. Gan To Kagaku Ryoho; 2009 Feb;36(2):329-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of higher efficacy by chemoradiotherapy for anal canal cancer from left cervix metastases to lymph nodes].
  • She noticed a left neck tumor and had a checkup by a nearby doctor.
  • In examination, the anal region had phyma in a rectal examination, and biopsy revealed it to be a squamous cell carcinoma.
  • For anal canal cancer cStage IV, we performed chemotherapies of S-1+CDDP and local radiotherapy.
  • We have continued chemotherapies in an outpatient department sequentially, but the image shows no increase of lymph gland nor increase of the primary tumor for 20 months with no decrease in QOL of the patient.
  • Chemoradiotherapy including S-1 was effective for this case of anal canal cancer distant metastasis for which no apparent cause has been established thus far.
  • [MeSH-major] Anus Neoplasms / drug therapy. Anus Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / blood. Colonoscopy. Female. Humans. Lymphatic Metastasis / pathology. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 19223758.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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13. Homsi J, Garrett C: Melanoma of the anal canal: a case series. Dis Colon Rectum; 2007 Jul;50(7):1004-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma of the anal canal: a case series.
  • PURPOSE: Anal melanoma is an uncommon and aggressive cancer.
  • METHODS: The medical records of patients with anal melanoma treated at the H.
  • Lee Moffitt Cancer and Research Institute between 1987 and 2004 were reviewed.
  • Published anal melanoma studies, including more than ten patients with outcome data, also were reviewed.
  • RESULTS: Twelve patients were identified (8 percent of all cancer of the anal canal).
  • Four patients had nodal involvement, and one had bone metastases at the time of diagnosis.
  • Five of the 11 patients without metastatic disease relapsed or died within the first year of diagnosis (4 had local excision and 1 had abdominoperineal resection).
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Digestive System Surgical Procedures / methods. Melanoma. Rectal Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prevalence. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 17468984.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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14. Mita MM, Tolcher A, Gordon MS, Rosen L, Mita A, Fine G, Choy G, Berk G: A phase Ib dose-escalation study of orally administered MP-470, a multi-kinase inhibitor and supressor of Rad51, in combination with carboplatin doublet containing regimens shows activity in highly refractory solid tumor patients. J Clin Oncol; 2009 May 20;27(15_suppl):e13511

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase Ib dose-escalation study of orally administered MP-470, a multi-kinase inhibitor and supressor of Rad51, in combination with carboplatin doublet containing regimens shows activity in highly refractory solid tumor patients.
  • : e13511 Background: MP-470 (MP) is an oral multi-targeted tyrosine kinase inhibitor which inhibits a number of validated tumor targets including c-kit, flt3, and PDGFα.
  • MP470 targets cancer cells by disrupting DNA repair, an important survival pathway in many human cancers.
  • Results presented herein are from two arms of a phase-Ib five arm trial of MP combined with standard of care (SOC) anti- cancer therapies.
  • Adults with ECOG PS of 0-2 and malignant disease appropriate for SOC regimens consisting of paclitaxel/carboplatin (PC), carboplatin/etoposide (CE), topotecan, docetaxel, and erlotinib were enrolled.
  • Six PRs (2 neuroendocrine, 2 SCLC, 1 NSCLC, 1 small cell of anal canal) and 3 SDs (≥ 4 cycles) was observed.
  • CONCLUSIONS: MP470 combined with carboplatin-containing regimens may promote tumor regression and may also sensitize/resensitize tumors to the anticancer effects of such agents.
  • An amendment will be issued to collect tumor tissue biopsy at baseline and during treatment to adequately evaluate DNA damage in tumor tissue.

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  • (PMID = 27961308.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Subramonia Iyer S, Akl A: A review of the outcomes of patients with anal cancer enrolled in the Hurley Cancer Registry: 1987-2004. J Clin Oncol; 2009 May 20;27(15_suppl):e15131

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A review of the outcomes of patients with anal cancer enrolled in the Hurley Cancer Registry: 1987-2004.
  • : e15131 Background: This paper describes the outcomes of patients with anal cancer enrolled in the Hurley Cancer Registry.
  • The Hurley cancer registry was searched using diagnosis codes for anal cancer.
  • The records retrieved, were reviewed for demographic and pathologic details,cancer recurrence, and vital status at last follow up.
  • RESULTS: Over a period of 18 years (1987 - 2004), there were 36 patients enrolled in the registry, with a diagnosis of anal cancer.
  • Mean age at diagnosis was 59.3 (SD 17.6) years for males, and 64.6 (SD 13.8) years for females.
  • Cumulative survival functions for the cohort were derived for the time points of 3-yrs and 5-yrs after diagnosis.
  • CONCLUSIONS: Among patients in the Hurley Cancer Registry, 1.
  • Squamous cell carcinoma is the commonest (75%) anal cancer.
  • 2. The risk of recurrence of anal cancer was 14% over 6-years, and 80% of recurrence was localised to the anal canal.

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  • (PMID = 27960904.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Hammad N, Philip PA, Shields AF, Heilbrun LK, Venkatramanamoorthy R, El-Rayes BF: A retrospective review of squamous cell carcinoma of the anal canal in HIV-positive and HIV-negative patients. J Clin Oncol; 2009 May 20;27(15_suppl):e15586

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A retrospective review of squamous cell carcinoma of the anal canal in HIV-positive and HIV-negative patients.
  • : e15586 Background: Human immunodeficiency virus (HIV) infected patients (pts) are at increased risk for squamous cell carcinoma of the anal canal (SCCAC) and the incidence of SCCAC has increased in the era of HAART (highly active antiretroviral therapy).
  • The aim of this study is to describe the outcome, tolerability, and overall survival (OS) in pts with and without HIV infection treated at Karmanos Cancer Institute, at Wayne State University from 1991 to 2007.
  • We collected data regarding HIV status, demographics (age, gender, race), stage at diagnosis, treatment, response to treatment, toxicity, and survival.

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  • (PMID = 27962344.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. You YN, Larson DW, Dozois EJ, Nelson H, Antpack Filho E, Klein K, Miller RC: Multimodality salvage therapy for anal cancer failing standard chemoradiation. J Clin Oncol; 2009 May 20;27(15_suppl):e15635

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodality salvage therapy for anal cancer failing standard chemoradiation.
  • : e15635 Background: Most squamous cell carcinomas of the anal canal (SCC) respond to chemoradiation, but effective therapy for locally-invasive(T4) or recurrent disease that fails standard chemoradiation and/or salvage abdominoperineal resection (APR) has not been clearly delineated.

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  • (PMID = 27962742.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Eng C, Chang GJ, Das P, Rodriguez-Bigas M, Skibber JM, Qiao W, Rosner GL, Ukegbu LT, Wolff RA, Crane CH: Phase II study of capecitabine and oxaliplatin with concurrent radiation therapy (XELOX-XRT) for squamous cell carcinoma of the anal canal. J Clin Oncol; 2009 May 20;27(15_suppl):4116

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II study of capecitabine and oxaliplatin with concurrent radiation therapy (XELOX-XRT) for squamous cell carcinoma of the anal canal.
  • : 4116 Background: Definitive therapy for squamous cell carcinoma (SCC) of the anal canal consists of external beam radiotherapy with concurrent 5-fluorouracil and mitomycin C or cisplatin.
  • The purpose of this study was to evaluate the tolerability and efficacy of XELOX-XRT as definitive treatment for anal cancer.
  • METHODS: Patients with histologically proven SCC of the anal canal, AJCC Stage II-IIIB (T<sub>2-4</sub> or N+M<sub>0</sub>), ECOG PS 0-1, HIV<sup>-</sup>, and no prior therapy were eligible for XELOX-based chemoradiotherapy.
  • CONCLUSIONS: The combination of capecitabine, oxaliplatin, and radiation therapy (XELOX-XRT) is effective for locally advanced squamous cell carcinoma of the anal canal.

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  • (PMID = 27961220.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Swampillai A, Williams M, Osborne M, Mawdsley S, Hughes R, Harrison M, Glynne-Jones R: A single-center study of the utility of squamous cell carcinoma antigen (SCCAg) levels in epidermoid carcinoma of the anal canal and margin (ECACM) treated with chemoradiation (CRT). J Clin Oncol; 2009 May 20;27(15_suppl):4117

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A single-center study of the utility of squamous cell carcinoma antigen (SCCAg) levels in epidermoid carcinoma of the anal canal and margin (ECACM) treated with chemoradiation (CRT).
  • : 4117 Background: SCCAg is a tumour marker expressed by ECACM, measured by microparticle enzyme immunoassay; normal range 0-150ng/dl.
  • Radiotherapy comprised the schedule of the UK Anal cancer Trial (ACT II).
  • Clinical stage at diagnosis- Tx (6) T1 (28), T2 (80), T3 (65), T4 (16), N0 (126), N+ (66) Nx (3).

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  • (PMID = 27961219.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Yap JC, Yang GY, Fakih M, Mashtare T, Bullard Dunn K, Kuvshinoff BW, Smith J, Khushalani NI, Gibbs JF: Primary adenocarcinoma of the anus: a 22-year SEER population database analysis. J Clin Oncol; 2009 May 20;27(15_suppl):e15072

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : e15072 Background: Most anal canal cancers consist of squamous cell carcinoma (SCCA).
  • Adenocarcinoma (AdenoCa) is rare and accounts for approximately 10% of anal cancers.
  • METHODS: The search of the SEER database revealed 1,008 pts who had pathologically confirmed anal cancers with either SCCA or AdenoCa.
  • All pts had single diagnosis of anal cancer with localized disease without nodal involvement.
  • On the other hand, among the AdenoCa subset, pts who had APR had better 10-yr OS than RT pts (53.8% vs. 0%, p=0.03) Conclusions: For localized anal SCCA, RT yielded equivalent overall survival as compared to APR.
  • On the other hand, pts with localized anal adenoCa appeared to do worse when APR was omitted.
  • Omission of APR in pts with anal canal adenoCa should be cautiously weighed.

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  • (PMID = 27964572.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Conroy T, Ducreux M, Lemanski C, Francois E, Giovannini M, Cvitkovic F, Mirabel X, Bouché O, Montoto-Grillot C, Peiffert D: Treatment intensification by induction chemotherapy (ICT) and radiation dose escalation in locally advanced squamous cell anal canal carcinoma (LAAC): Definitive analysis of the intergroup ACCORD 03 trial. J Clin Oncol; 2009 May 20;27(15_suppl):4033

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment intensification by induction chemotherapy (ICT) and radiation dose escalation in locally advanced squamous cell anal canal carcinoma (LAAC): Definitive analysis of the intergroup ACCORD 03 trial.
  • The tumour complete response (+ partial response) at 2 months were: A=78% (+18%), B=86% (+13%), C=74% (+21%), D=74 % (+22%) (NS).

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  • (PMID = 27961547.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Damin DC, Rosito MA, Schwartsmann G: Sentinel lymph node in carcinoma of the anal canal: a review. Eur J Surg Oncol; 2006 Apr;32(3):247-52
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sentinel lymph node in carcinoma of the anal canal: a review.
  • AIMS: To review the studies investigating the efficacy of the sentinel lymph node (SLN) procedure in anal canal carcinoma and to evaluate its potential role in guiding a more selective approach for patients with the malignancy.
  • METHODS: A literature search in the PubMed database was preformed using the key words "sentinel lymph node" and "anal cancer".
  • All indexed original articles (except case reports) on the SLN procedure in cancer of the anal canal were analysed.
  • The detection of occult metastases in clinically unsuspicious nodes represents an important improvement in the process of staging these patients, which has not been possible with any other method of diagnosis.
  • Although SLN procedure is still in an early phase of investigation in this type of cancer, it emerges as an objective method to guide individual therapeutic decisions.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma / secondary
  • [MeSH-minor] Humans. Inguinal Canal. Lymph Nodes / pathology. Lymph Nodes / radionuclide imaging. Lymphatic Metastasis. Sentinel Lymph Node Biopsy

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  • (PMID = 16289647.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 55
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23. Bui T, Harvey J, Brown E, Scott M, Haines T, Davidson K: Conformal external beam radiotherapy in the treatment of anal canal carcinoma: a retrospective study of a genital organ sparing technique. J Med Imaging Radiat Oncol; 2009 Aug;53(4):396-404
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conformal external beam radiotherapy in the treatment of anal canal carcinoma: a retrospective study of a genital organ sparing technique.
  • To investigate and compare the dosimetric distribution of a conventional radiotherapy (CRT) technique and a genital organ sparing three-dimensional conformal radiotherapy (3DCRT) technique for the treatment of anal canal cancer.
  • Twenty-four patients with anal canal cancer treated between January 2002 and December 2006 were investigated.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Radiation Injuries / prevention & control. Radiation Protection / methods. Radiotherapy, Conformal / methods

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  • (PMID = 19695047.001).
  • [ISSN] 1754-9485
  • [Journal-full-title] Journal of medical imaging and radiation oncology
  • [ISO-abbreviation] J Med Imaging Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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24. Tournier-Rangeard L, Peiffert D, Lafond C, Mege A, Metayer Y, Marchesi V, Buchheit I, Uwer L, Conroy T, Kaminsky MC: [Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation]. Cancer Radiother; 2007 Jun;11(4):169-77
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Long-term results and prognostic factors of squamous cell carcinoma of the anal canal treated by irradiation].
  • [Transliterated title] Résultats à long terme et facteurs pronostiques des carcinomes épidermoïdes du canal anal traités par irradiation.
  • PURPOSE: To analyze the prognostic factors of loco regional control (LRC), specific survival (SS) and sphincter conservation (SC) of patients treated by curative and conservative irradiation for an epidermoid cancer of anal canal in our institution.
  • In multivariate analysis, tumor size (>or=40 mm) [RR=2.1], node involvement (RR=2.4), and poor response (<75%) to first course irradiation [RR=1.9], local relapse (RR=4.5) and distant metastases were factors of poor prognosis for SS.
  • Prognosis factors of LCR were tumor size (RR=2.5), response to first course of irradiation (RR=2.9).
  • Prognosis factors of SC were tumor size (RR=1.9) and response to first course of irradiation (RR=2.4).
  • As well as initial tumor extension, response to first course of irradiation was found as prognostic factor on LCR, SS, SC.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Carcinoma, Squamous Cell / radiotherapy

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  • (PMID = 17400501.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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25. Shia J: An update on tumors of the anal canal. Arch Pathol Lab Med; 2010 Nov;134(11):1601-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An update on tumors of the anal canal.
  • CONTEXT: The anal canal possesses complex anatomy and histology and gives rise to a variety of tumor types.
  • Challenging issues remain with regard to both the pathologic diagnosis and the clinical management of these tumors.
  • OBJECTIVES: To provide an updated overview of the histogenesis, clinical and pathologic characteristics, diagnostic terminology, and relevant clinical management of the various types of anal canal tumors.
  • DATA SOURCES: Recent literature on clinical and pathologic characteristics of anal canal tumors.
  • CONCLUSIONS: Although most anal canal tumors are of squamous lineage, a complex variety of other tumors also occurs.
  • Recognition of such diverse tumor entities will allow accurate pathologic diagnosis and most optimal clinical management.
  • [MeSH-major] Adenocarcinoma / pathology. Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. Melanoma / pathology

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  • (PMID = 21043813.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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26. Kratz JR, Deshpande V, Ryan DP, Goldstein AM: Anal canal duplication associated with presacral cyst. J Pediatr Surg; 2008 Sep;43(9):1749-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal duplication associated with presacral cyst.
  • Anal canal duplications are rare congenital malformations, with fewer than 50 reported cases in the literature.
  • Anal canal duplications are noncommunicating second anal orifices located posterior to the true anus without other associated hindgut duplications.
  • Here, we report on a 16-year-old girl with a symptomatic anal canal duplication associated with a presacral cystic component.
  • An overview of the clinical presentation, radiologic workup, surgical treatment, and histologic features of anal canal duplications is provided.
  • [MeSH-major] Anal Canal / abnormalities. Anal Canal / surgery. Cysts / surgery

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  • [ErratumIn] J Pediatr Surg. 2009 Mar;44(3):662-3
  • (PMID = 18779021.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Narci A, Dilek FH, Cetinkurşun S: Anal canal duplication. Eur J Pediatr; 2010 May;169(5):633-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal duplication.
  • INTRODUCTION: Anal canal duplication (ACD) is an extremely rare congenital intestinal anomaly.
  • ACD is defined as a second anal orifice located posterior to the true anus ending blindly without connection to the rectum.
  • It can be confused with other types of anorectal pathologies, such as hemorrhoids, fistula-in-ano, and perianal abscess at the time of diagnosis.
  • Although ACD is often asymptomatic, it should be removed surgically because of the risk of inflammatory complications and colloidal cancer.
  • [MeSH-major] Anal Canal / abnormalities

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  • [Cites] Pediatr Surg Int. 2002 Mar;18(2-3):195-7 [11956798.001]
  • [Cites] Eur J Pediatr Surg. 2001 Jun;11(3):186-91 [11475116.001]
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  • (PMID = 19856187.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Val-Bernal JF, Mayorga M, Diego C, González-Vela MC: Pedunculated polypoid lymphangioma of the anal canal. Pathol Int; 2008 Jul;58(7):442-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pedunculated polypoid lymphangioma of the anal canal.
  • To the authors' knowledge a lymphangioma of the anal canal has not been reported.
  • Described herein is a case of pedunculated polypoid lymphangioma of the right lateral wall on the transitional zone of the anal canal measuring 1.7 x 1.3 x 1 cm in a 40-year-old woman.
  • A pedicle does not exclude the endoscopic diagnosis of lymphangioma.
  • Lymphangioma must be included in the differential diagnosis of polypoid lesions of the anal canal.
  • [MeSH-major] Anus Neoplasms / pathology. Lymphangioma / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Rectal Fistula / pathology

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  • (PMID = 18577114.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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29. Rivero Fernández M, García Martos M, Sanz Moya P, Vázquez Romero M, Fernández Amago MT, García Benayas MT, Sánchez-Pobre Bejarano P: [Kaposi's sarcoma with colorectal and anal canal involvement]. Gastroenterol Hepatol; 2010 Aug-Sep;33(7):508-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Kaposi's sarcoma with colorectal and anal canal involvement].
  • [Transliterated title] Sarcoma de Kaposi con afectación colorrectal y del canal anal.
  • Kaposi's sarcoma (KS) is a low-grade vascular tumor, with four main variants, one of which is fairly prevalent in HIV-infected patients.
  • The gastrointestinal tract is involved in 40% of patients, but rectal and anal canal involvement is exceptional.
  • We report the case of a 39-year-old HIV-infected man with an unusual presentation of KS with colorectal and anal canal involvement in the absence of cutaneous disease.
  • [MeSH-major] Anus Neoplasms. Colorectal Neoplasms. Neoplasms, Multiple Primary. Sarcoma, Kaposi

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  • [Copyright] .
  • (PMID = 20630624.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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30. Liu J, Guaderrama N, Nager CW, Pretorius DH, Master S, Mittal RK: Functional correlates of anal canal anatomy: puborectalis muscle and anal canal pressure. Am J Gastroenterol; 2006 May;101(5):1092-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Functional correlates of anal canal anatomy: puborectalis muscle and anal canal pressure.
  • BACKGROUND: Resting and squeeze pressures in the anal canal are thought to reflect the contributions of the internal anal sphincter (IAS) and the external anal sphincter (EAS) respectively.
  • Role of the puborectalis muscle (PRM) in the genesis of anal canal pressure is not known.
  • OBJECTIVES: To determine the functional correlates of anal canal anatomy.
  • METHODS: Seventeen asymptomatic nulliparous women were studied using simultaneous 3D ultrasound images and manometry of the anal canal.
  • RESULTS: Anal canal high pressure zone was 39 +/- 1 mm in length.
  • EAS was located in the distal (length 19 +/- 1 mm) and PRM in the proximal part (length 18 +/- 1 mm) of the anal canal.
  • The station pull-through technique revealed increases in pressure with voluntary squeeze in the proximal as well as distal parts of the anal canal.
  • Proximal anal canal pressure, located in the PRM zone, showed greater circumferential asymmetry than the distal anal canal pressure, located in the EAS zone. CONCLUSIONS:.
  • (1) PRM contributes to the squeeze pressure in the proximal part of the anal canal and EAS to the distal anal canal. (2) PRM squeeze-related increase in anal canal pressure might be important in the anal continence mechanism.
  • [MeSH-major] Anal Canal / anatomy & histology. Anal Canal / physiology. Muscle, Skeletal / physiology

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  • (PMID = 16606349.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK066846
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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31. Berton F, Gola G, Wilson SR: Sonography of benign conditions of the anal canal: an update. AJR Am J Roentgenol; 2007 Oct;189(4):765-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonography of benign conditions of the anal canal: an update.
  • OBJECTIVE: The objective of this article is to describe our experience with sonography for the study of benign conditions of the anal canal and perianal soft tissues.
  • CONCLUSION: Assessment of the anal sphincters in patients with fecal incontinence and documentation of perianal inflammatory masses and tracts in those with perianal inflammatory disease are the major indications for imaging the anal canal.
  • We augment traditional transanal sonography with transperineal scanning in both sexes and transvaginal scanning in women to better show the anal canal in its quiet state to allow an accurate assessment of the integrity of the anal sphincters and of evidence of acute or chronic inflammatory involvement.
  • [MeSH-major] Anal Canal / ultrasonography. Image Enhancement / methods. Intestinal Diseases / ultrasonography. Ultrasonography / methods

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  • (PMID = 17885043.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 50
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32. Elchalal U, Yanai N, Valsky DV, Sela HY, Erez Y, Yagel S, Nadjari M: Application of 3-dimensional ultrasonography to imaging the fetal anal canal. J Ultrasound Med; 2010 Aug;29(8):1195-201

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Application of 3-dimensional ultrasonography to imaging the fetal anal canal.
  • OBJECTIVE: Ultrasonography has been applied previously to the assessment of the fetal anal canal.
  • We aimed to examine the potential of 3-dimensional ultrasonography (3DUS) in the evaluation of the fetal anal canal and to obtain normal fetal anal canal measurements.
  • In addition to the ordered scan, 3DUS imaging of the fetal anal canal was performed.
  • Measurements of the fetal anal canal anteroposterior diameter, lateral diameter, and length were performed in transverse and sagittal planes, respectively, and scatterplots of these dimensions were created.
  • The anteroposterior diameter of the fetal anal canal in this study group ranged from 4 to 21 mm (mean, 11.2 mm; SD, +/-3.5 mm), whereas the lateral diameter ranged from 7 to 18 mm (mean, 9.1 mm; SD, +/-3.0 mm).
  • The length of the fetal anal canal in this study group ranged from 3 to 24 mm (mean, 14.3 mm; SD, +/-3.8 mm).
  • CONCLUSIONS: Ultrasonographic assessment of the fetal anal canal with 3DUS is feasible.
  • Scatterplots were created for internal anal sphincter width and length measurements from 16 to 39 weeks' gestation.
  • We speculate that 3DUS assessment of the fetal anal canal may improve detection rates of disorders involving this system.
  • [MeSH-major] Anal Canal / ultrasonography. Imaging, Three-Dimensional / methods. Ultrasonography, Prenatal / methods

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  • (PMID = 20660453.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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33. Blumetti J, Bastawrous AL: Epidermoid cancers of the anal canal: current treatment. Clin Colon Rectal Surg; 2009 May;22(2):77-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermoid cancers of the anal canal: current treatment.
  • Epidermoid carcinoma of the anal canal is an uncommon disease, but has increased in incidence with the HIV epidemic.
  • This review provides an overview of the historical, current, and future treatments of epidermoid anal canal malignancies.

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  • [Cites] BMJ. 2004 Nov 27;329(7477):1272-6 [15564260.001]
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  • (PMID = 20436831.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780240
  • [Keywords] NOTNLM ; Anal canal malignancy / Nigro protocol / chemoradiation / epidermoid carcinoma
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34. Vuong T, Kopek N, Ducruet T, Portelance L, Faria S, Bahoric B, Devic S: Conformal therapy improves the therapeutic index of patients with anal canal cancer treated with combined chemotherapy and external beam radiotherapy. Int J Radiat Oncol Biol Phys; 2007 Apr 1;67(5):1394-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conformal therapy improves the therapeutic index of patients with anal canal cancer treated with combined chemotherapy and external beam radiotherapy.
  • PURPOSE: To evaluate the clinical outcomes of three-dimensional conformal radiotherapy (3D-CRT) in patients with anal canal cancer, in terms of local control (LC), freedom from relapse (FFR), and overall survival (OS) rates, and to estimate long-term toxicity data.
  • CONCLUSION: The use of 3D-CRT allows patients with anal canal cancer to complete radiation and chemotherapy without interruption for toxicity, with significant improvements in LC, FFR, and OS.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / drug therapy. Anus Neoplasms / radiotherapy. Radiotherapy, Conformal

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  • (PMID = 17276620.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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35. Komissarov IA, Kolesnikov NG, Filippov DV, Komissarov MI: [First experience with gel plasty of the anal canal in children with fecal incontinence]. Vestn Khir Im I I Grek; 2010;169(3):57-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [First experience with gel plasty of the anal canal in children with fecal incontinence].
  • Fecal incontinence in children after surgical correction of anorectal defects and trauma of the holding apparatus of the rectum in certain cases can be dependent on low basal pressure in the anal canal at the expense of incompetence of the interior sphincter muscle of the anus.
  • In order to eliminate low pressure in the anal canal we introduced polyacrylamide gel "DAM +" into its submucous layer.
  • The introduction of this volume-forming substance into the anal canal was an effective procedure.
  • [MeSH-major] Acrylic Resins / therapeutic use. Anal Canal / surgery. Fecal Incontinence / surgery

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  • (PMID = 20804027.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / polyacrylamide gels
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36. Regadas FS, Murad-Regadas SM, Lima DM, Silva FR, Barreto RG, Souza MH, Regadas Filho FS: Anal canal anatomy showed by three-dimensional anorectal ultrasonography. Surg Endosc; 2007 Dec;21(12):2207-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal anatomy showed by three-dimensional anorectal ultrasonography.
  • BACKGROUND: Demonstrate precisely the anatomic configuration of the anal canal and the length and thickness of the anal sphincters using three-dimensional (3-D) anorectal ultra-sonography in both genders.
  • The anal canal was analyzed, measuring the length and thickness of the external anal sphincter (EAE), internal anal sphincter (IAS), puborectalis muscle (PR) and the gap (distance from the anterior EAS to the anorectal junction) in the midline longitudinal (ML) and transverse (MT) planes, and the results were compared between quadrants and genders.
  • The anterior upper anal canal is an extension of the rectal wall with all layers clearly identified.
  • The anterior IAS is formed in the distal upper anal canal and is significantly shorter in female than in male in all quadrants.
  • CONCLUSION: 3-D anal endosonography enabled measurement of the different anatomical structures of the anal canal and demonstrated its asymmetrical configuration.
  • [MeSH-major] Anal Canal / anatomy & histology. Anal Canal / diagnostic imaging. Endosonography. Imaging, Three-Dimensional

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  • (PMID = 17479327.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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37. Zaleski L, Turiansky GW: Squamous cell carcinoma of the anal canal. Cutis; 2010 Mar;85(3):143-5
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma of the anal canal.
  • Squamous cell carcinoma of the anal canal (SCCAC) is an increasing concern in the human immunodeficiency virus (HIV)-positive population in the highly active antiretroviral therapy (HAART) era.
  • A discussion of the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of SCCAC is presented.
  • [MeSH-major] Anus Neoplasms / etiology. Anus Neoplasms / therapy. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / therapy
  • [MeSH-minor] Antiviral Agents / therapeutic use. HIV Infections / complications. HIV Infections / pathology. HIV Infections / therapy. Humans. Risk Factors. Tumor Virus Infections / complications. Tumor Virus Infections / pathology. Tumor Virus Infections / therapy

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  • [CommentIn] Cutis. 2010 Mar;85(3):119 [20408506.001]
  • (PMID = 20408513.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents
  • [Number-of-references] 12
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38. Rousseau DL Jr, Thomas CR Jr, Petrelli NJ, Kahlenberg MS: Squamous cell carcinoma of the anal canal. Surg Oncol; 2005 Nov;14(3):121-32
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  • [Title] Squamous cell carcinoma of the anal canal.
  • Squamous cell carcinoma (SCC) of the anal canal is a rare condition with increasing incidence rates in the United States population in the past several decades.
  • This review article provides a complete overview of the etiology, anatomy and the approach to the multidisciplinary management of the patient with anal SCC.
  • Chemoradiation therapy for the treatment of SCC of the anal canal provides excellent disease control and survival while preserving anal sphincter function in the majority of patients.
  • The surgeon plays a key role in the diagnosis and follow-up of this disease.
  • [MeSH-major] Anus Neoplasms / surgery. Carcinoma, Squamous Cell / surgery


39. Martin FT, Kavanagh D, Waldron R: Squamous cell carcinoma of the anal canal. Surgeon; 2009 Aug;7(4):232-7
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  • [Title] Squamous cell carcinoma of the anal canal.
  • Squamous cell carcinoma ofthe anal canal represents 1.5% of all malignancies affectingthe gastrointestinal tract.
  • Work by Nigro et al. has revolutionised how we currently manage carcinoma of the anal canal, demonstrating combined modality chemoradiotherapy as an appropriate alternative to surgical resection with the benefit of preserving sphincter function.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / therapy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / therapy

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  • (PMID = 19736891.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Number-of-references] 57
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40. Cattle KR, Telford K, Kiff ES: Changes in fatigability of the striated anal canal after childbirth. Colorectal Dis; 2010 Sep;12(9):880-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changes in fatigability of the striated anal canal after childbirth.
  • AIM: Anal manometry is an established assessment tool for patients with faecal incontinence.
  • The aim of this study was to compare manometry and fatigability of the anal canal in nulliparous women before and after childbirth.
  • Resting anal canal pressure was not significantly different before and after delivery (57.1 +/- 13.6 vs 51.1 +/- 11.9 cmH(2)O, P = 0.1).
  • CONCLUSION: Maximal squeeze pressure and fatigue rate of the anal canal are significantly reduced after childbirth.
  • Resting anal canal pressure and FRI are not significantly different.
  • [MeSH-major] Anal Canal / physiopathology. Fecal Incontinence / physiopathology. Muscle Fatigue / physiology. Postpartum Period / physiology

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  • (PMID = 19486090.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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41. Jung SA, Pretorius DH, Weinstein M, Nager CW, Den-Boer D, Mittal RK: Closure mechanism of the anal canal in women: assessed by three-dimensional ultrasound imaging. Dis Colon Rectum; 2008 Jun;51(6):932-9
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  • [Title] Closure mechanism of the anal canal in women: assessed by three-dimensional ultrasound imaging.
  • PURPOSE: To describe the functional correlates of anal canal anatomy using 3 dimensional ultrasound imaging.
  • The bag was placed along the anal canal and inflated with 20 to 45 ml water, in 5-ml increments.
  • At each volume, a three-dimensional ultrasound volume of the anal canal was obtained while the subjects were at rest and squeeze.
  • The flared ends of the funnels correspond with the proximal and distal margins of the puborectalis muscle and external anal sphincter respectively.
  • With increasing bag volumes, the length of completely closed segment of anal canal decreased.
  • The last anal segment to open at rest was the one surrounded by all three structures.
  • Anal contraction resulted in reduction of the anal canal cross-sectional area; the least compliant part of the anal canal was the one surrounded by external anal sphincter.
  • CONCLUSION: The internal anal sphincter, external anal sphincter, and puborectalis muscle are all involved in the anal canal closure function.
  • During contraction, the external anal sphincter is the strongest component of anal canal closure mechanism.
  • [MeSH-major] Anal Canal / physiology. Anal Canal / ultrasonography. Imaging, Three-Dimensional

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  • (PMID = 18330648.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R0-1 DK60733
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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42. Stanojević G, Rancić Z, Jovanović M, Stojanović M, Mihailović D, Branković B: [Anal canal melanoma-- case report]. Acta Chir Iugosl; 2006;53(3):83-5
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  • [Title] [Anal canal melanoma-- case report].
  • Anal canal melanoma is a rare disease comprising 1% of all colorectal ie. anal malignant tumours with very poor long term prognosis.
  • At the moment of diagnosis even 30% of the patients have distant metastases.
  • Modern approach to the anal canal melanoma treatment implies two types of intervention: wide local excision preserving the sphincter mechanism and abdominoperineal resection of the rectum.
  • The authors report on a 61 years old women in which anal canal melanoma with left inguinal lymphatic metastases was detected during the inspection of "haemorrhoids".
  • After the diagnosis was established, abdominoperineal resection of the rectum was performed with dissection of both inguinal regions.
  • [MeSH-major] Anus Neoplasms. Melanoma

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  • (PMID = 17338206.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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43. Gu J, Li J, Yao Y, Lu A, Wang H: Synchronous rectal adenocarcinoma and anal canal adenocarcinoma. Front Med China; 2007 Jul;1(3):333-7
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  • [Title] Synchronous rectal adenocarcinoma and anal canal adenocarcinoma.
  • It is difficult to distinguish a rectal carcinoma with anal metastases from coexistent synchronous anorectal carcinomas.
  • The therapeutic strategy for rectal and anal carcinoma is so different that it should be clearly identified.
  • Five months after resection, he developed an adenocarcinoma in the anal canal.
  • The index tumor demonstrated CK 7-/CK 20+ and the second showed CK7+/CK20+.
  • For this reason, we believe the present case had synchronous adenocarcinomas arising from anal canal and the rectum separately.
  • It is very important to differentiate the anorectal lesions pathologically because of the impact on the therapeutic options available, especially for the lesion arising in the anal canal.

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  • (PMID = 24573877.001).
  • [ISSN] 1673-7342
  • [Journal-full-title] Frontiers of medicine in China
  • [ISO-abbreviation] Front Med China
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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44. Padda BS, Jung SA, Pretorius D, Nager CW, Den-Boer D, Mittal RK: Effects of pelvic floor muscle contraction on anal canal pressure. Am J Physiol Gastrointest Liver Physiol; 2007 Feb;292(2):G565-71
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  • [Title] Effects of pelvic floor muscle contraction on anal canal pressure.
  • The role of pelvic floor muscle contraction in the genesis of anal canal pressure is not clear.
  • We studied the effects of vaginal distension on anal canal pressure in 15 nullipara asymptomatic women.
  • Anal pressure, rest, and squeeze were measured using station pull-through manometry techniques with no vaginal probe, a 10-mm vaginal probe, and a 25-mm vaginal probe in place.
  • In the presence of the 25-mm vaginal probe, rest and squeeze anal pressures in the proximal part of the anal canal were significantly higher compared with no vaginal probe or the 10-mm vaginal probe.
  • On the other hand, distal anal pressures were not affected by any of the vaginal probes.
  • Atropine at 15 micro g/kg had no influence on the rest and squeeze anal pressures with or without vaginal distension.
  • Our data suggest that pelvic floor contractions increase pressures in the proximal part of the anal canal, which is anatomically surrounded by the puborectalis muscle.
  • We propose that pelvic floor contraction plays an important role in the fecal continence mechanism by increasing anal canal pressure.
  • [MeSH-major] Anal Canal / physiology. Muscle Contraction / physiology. Muscle, Skeletal / physiology. Pelvic Floor / physiology

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  • (PMID = 17023551.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01-DK-60733
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parasympatholytics; 7C0697DR9I / Atropine
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45. Thalheimer L, Richmond B, Lohan J: Leiomyosarcoma of the anal canal: case report and review of the literature. Am Surg; 2008 Jan;74(1):76-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyosarcoma of the anal canal: case report and review of the literature.
  • A rare case of a leiomyosarcoma of the anal canal is presented.
  • Endorectal ultrasound revealed a mass invading both sphincters (T4 lesion), and extending 6 cm into the anal canal.
  • Colonoscopy revealed an ulcerated area in the anal canal, of which biopsies revealed high-grade leiomyosarcoma--only the eighteenth such case at the time of this submission.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / surgery. Leiomyosarcoma / diagnosis. Leiomyosarcoma / surgery

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  • (PMID = 18274436.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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46. Rajasekaran MR, Jiang Y, Bhargava V, Littlefield R, Lee A, Lieber RL, Mittal RK: Length-tension relationship of the external anal sphincter muscle: implications for the anal canal function. Am J Physiol Gastrointest Liver Physiol; 2008 Aug;295(2):G367-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Length-tension relationship of the external anal sphincter muscle: implications for the anal canal function.
  • We studied active and passive length-tension characteristics of external anal sphincter (EAS) in vivo and in vitro to determine the optimal and operational length of rabbit EAS.
  • For in vivo studies, female rabbits (n = 19) were anesthetized and anal canal pressure was recorded by use of a sleeve sensor placed in the custom-designed catheter holders of 4.5-, 6-, and 9-mm diameters.
  • Sarcomere length of EAS muscle was measured by laser diffraction technique with no probe and three probes in the anal canal.
  • In vivo studies revealed a probe size-dependent increase in anal canal pressure and tension.
  • Maximal increase in anal canal tension with stimulation was recorded with the 9-mm probe.
  • Increases in anal canal tension with increase in probe size were completely abolished by pancuronium bromide.
  • EAS muscle sarcomere length without and with 9-mm probe in the anal canal were 2.11 +/- 0.08 and 2.99 +/- 0.07 microm, respectively.
  • Our findings provide insight into EAS function and we propose the possibility of increasing anal canal pressure by surgical manipulation of the EAS sarcomere length.

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  • [Cites] Pflugers Arch. 1999 Oct;438(5):665-70 [10555564.001]
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  • (PMID = 18599590.001).
  • [ISSN] 0193-1857
  • [Journal-full-title] American journal of physiology. Gastrointestinal and liver physiology
  • [ISO-abbreviation] Am. J. Physiol. Gastrointest. Liver Physiol.
  • [Language] ENG
  • [Grant] United States / NICHD NIH HHS / HD / 5R24 HD-050837-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 169D1260KM / Nitroprusside; J76UF062FS / Pancuronium
  • [Other-IDs] NLM/ PMC2519855
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47. Kuroda N, Tanida N, Ohara M, Hirouchi T, Mizuno K, Kubo A, Lee GH: Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin. Med Mol Morphol; 2007 Mar;40(1):50-3
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin.
  • Anal canal adenocarcinomas arising in the anal ducts or glands are very rare neoplasms, and few useful immunohistochemical markers of these carcinomas are known to date.
  • A 57-year-old man presented with anal bleeding, difficulty of defecation, and anal pain.
  • Macroscopic findings of the surgically resected material showed circular stenosis of the anal canal.
  • Immunohistochemically, normal rectal-type mucosa and normal anal ducts/glands showed the patterns of cytokeratin 7 (CK7)(-)/CK19(+, focal)/MUC5AC(-) and CK7(+, diffuse)/CK19(+, diffuse)/MUC5AC(+, focal), respectively, and neoplastic cells showed the pattern of CK7(+, diffuse)/CK19(+, diffuse)/MUC5AC(+, focal).
  • Finally, our preliminary report suggests that the immunohistochemical combination of CK7, CK19, and MUC5AC may be an available marker for adenocarcinoma of anal ducts/glands origin.
  • [MeSH-major] Adenocarcinoma / pathology. Anal Canal / pathology. Anus Neoplasms / pathology. Mucins / metabolism

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  • (PMID = 17384991.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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48. Chapet O, Gerard JP, Riche B, Alessio A, Mornex F, Romestaing P: Prognostic value of tumor regression evaluated after first course of radiotherapy for anal canal cancer. Int J Radiat Oncol Biol Phys; 2005 Dec 1;63(5):1316-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic value of tumor regression evaluated after first course of radiotherapy for anal canal cancer.
  • PURPOSE: To evaluate whether the tumor response after an initial course of irradiation predicts for colostomy-free survival and overall survival in patients with anal canal cancer.
  • An evaluation of tumor regression, before the boost, was available for 221 patients.
  • They were divided into four groups according to the tumor response: <70%, 70-80%, >80% but <100%, and 100%.
  • Two groups could be differentiated according to the percentage of tumor regression before the boost: >80% vs. < or = 80%.
  • The group with a T3-T4 lesion and tumor regression < or = 80% had the poorest overall (52.8% +/- 12.3%), disease-free (19.9% +/- 9.9%), and colostomy-free survival (24.8% +/- 11.2%) rates.
  • CONCLUSION: The amount of tumor regression before EBRT or brachytherapy boost is a strong prognostic factor of disease control without colostomy.
  • [MeSH-major] Anus Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Brachytherapy. Colostomy. Disease-Free Survival. Female. Humans. Iridium Radioisotopes / therapeutic use. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Survival Rate

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  • (PMID = 16169674.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iridium Radioisotopes
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49. Rosset L, Allal AS, Morel P, Roche B, Roth AD: Complete closure of cancer-related anovaginal and anoperineal fistulas in locally advanced anal canal carcinomas by upfront intra-arterial chemotherapy followed by combined radiochemotherapy: report of two cases. Dis Colon Rectum; 2006 Dec;49(12):1927-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complete closure of cancer-related anovaginal and anoperineal fistulas in locally advanced anal canal carcinomas by upfront intra-arterial chemotherapy followed by combined radiochemotherapy: report of two cases.
  • PURPOSE: Cancer-related fistulas are a major problem in locally advanced anal canal carcinoma, because conservative radiochemotherapy may not be recommended in this setting.
  • METHODS: Because chemotherapy can lead to closure of cancer-related fistulas and local intra-arterial chemotherapy is effective in locally advanced anal canal cancer, we treated two anal canal carcinoma patients presenting with cancer-related fistulas with upfront intra-arterial chemotherapy followed by radiochemotherapy, leading to complete closure of fistulas.
  • CONCLUSIONS: This conservative approach combining local intra-arterial chemotherapy and standard radiochemotherapy is feasible and should be considered in the management of such locally advanced anal canal carcinoma.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma / therapy. Rectal Fistula / therapy

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  • (PMID = 17096179.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Li LR, Wan DS, Pan ZZ, Zhou ZW, Chen G, Wu XJ, Lu ZH, Ding PR: [Clinical features and treatment of 49 patients with anal canal adenocarcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 Sep;9(5):402-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical features and treatment of 49 patients with anal canal adenocarcinoma].
  • OBJECTIVE: To investigate the clinical features and treatment of anal canal adenocarcinoma.
  • METHODS: Clinical data of 49 patients with anal canal adenocarcinoma treated in our hospital from January 1965 to March 2002 were analyzed retrospectively.
  • Anal bleeding, tapering stool and anal lump were the most common symptoms.
  • CONCLUSIONS: Anal canal adenocarcinoma is a rare and fatal malignancy.
  • [MeSH-major] Adenocarcinoma / therapy. Anus Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 17043960.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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51. Radomirov R, Negrev N, Itzev DE, Stavreva G: Activation-dependent descending reflex evacuation motority of anal canal in rat model. Arch Ital Biol; 2010 Dec;148(4):377-88
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  • [Title] Activation-dependent descending reflex evacuation motority of anal canal in rat model.
  • The evacuative motor responses of the anal canal and recto-anal reflexes during defecation were studied in an isolated rat recto-anal model preparation using (i) partitioned organ bath, (ii) electrical stimulation, (iii) balloon distension and (iv) morphological techniques.
  • Electrical field stimulation applied to the anal canal or to the distal part of the rectum elicited tetrodotoxin (10(-7) M)-sensitive frequency-dependent local or descending contractions of the anal canal and the local responses were bigger in amplitude (14.9 ± 1.35 mN) than the descending contractions (5.3 ± 0.7 mN at frequency of 5 Hz, p < 0.05).
  • The balloon-induced distension of the distal rectum evoked descending responses of the anal canal consisting of a short contraction (1.50 ± 0.18 mN) followed by deep relaxation (3.12 ± 0.34 mN).
  • In the presence of atropine (3 x 10(-7) M) the electrically-elicited (5 Hz) local or descending contractions of the anal canal were suppressed and a relaxation revealed.
  • During atropine treatment, spantide (10(-7) M) lowered even more the contractile component of the anal canal response.
  • ChAT-, substance P- and NADPH-diaphorase-positive perikarya and nerve fibers were observed in myenteric ganglia of the anal canal.
  • The results suggest activation-dependent descending reflex motority of the anal canal involving electrical stimulation-displayed cholinergic and tachykininergic and distension manifested nitrergic neuro-muscular communications.
  • [MeSH-major] Afferent Pathways / physiology. Anal Canal / physiology. Muscle Contraction / physiology. Rectum / physiology. Reflex / physiology

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  • (PMID = 21308650.001).
  • [ISSN] 0003-9829
  • [Journal-full-title] Archives italiennes de biologie
  • [ISO-abbreviation] Arch Ital Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anesthetics, Local; 0 / Enzyme Inhibitors; 0 / Parasympatholytics; 2149-70-4 / Nitroarginine; 33507-63-0 / Substance P; 4368-28-9 / Tetrodotoxin; 7C0697DR9I / Atropine; 91224-37-2 / spantide; EC 1.6.99.1 / NADPH Dehydrogenase; EC 2.3.1.6 / Choline O-Acetyltransferase
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52. Birnbaum DJ, Berdah SV, Eyre-Brooke I, Moutardier V, Brunet C: Very low stapling of the anal canal in laparoscopic ileal pouch-anal anastomosis. Dis Colon Rectum; 2010 Jul;53(7):1093-6
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  • [Title] Very low stapling of the anal canal in laparoscopic ileal pouch-anal anastomosis.
  • Performing a double-stapled ileal pouch-anal anastomosis requires very low stapling of the anal canal.
  • The anal canal is then transected at the desired level relative to the dentate line.
  • [MeSH-major] Anal Canal / surgery. Colonic Diseases / surgery. Colonic Pouches. Ileum / surgery. Laparoscopy / methods. Suture Techniques / instrumentation. Sutures

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  • (PMID = 20551765.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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53. Chen LS, Li TY, Cao YF, Liang JL, Zhang S, Tang WZ, Tang ZJ, Gao F: [Expression of P33ING1, P53 and their relationship with apoptosis in anal canal carcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 Jul;9(4):338-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of P33ING1, P53 and their relationship with apoptosis in anal canal carcinoma].
  • OBJECTIVE: To explore the expressions of P33ING1, P53 and their relationships with apoptosis in anal canal carcinoma (ACC).
  • METHODS: The expressions of P33ING1, P53 proteins were measured by immunohistochemistry method (SP method), and apoptosis was detected in 42 cases with ACC, 36 cases with anal canal adenoma (ACA) or anal canal papilloma (ACP), and 40 cases with paraanal inflammatory mass(PAIM).
  • [MeSH-major] Anus Neoplasms / metabolism. Apoptosis. Carcinoma / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Nuclear Proteins / metabolism. Tumor Suppressor Protein p53 / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 16886119.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / ING1 protein, human; 0 / Intracellular Signaling Peptides and Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins
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54. Suenaga M, Oya M, Ueno M, Yamamoto J, Yamaguchi T, Mizunuma N, Hatake K, Kato Y, Muto T: Anal canal carcinoma with Pagetoid spread: report of a case. Surg Today; 2006;36(7):666-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal carcinoma with Pagetoid spread: report of a case.
  • A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal.
  • Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal.
  • During transanal local excision of the tumor, an abnormality of the perianal skin was recognized.
  • Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin.
  • Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion.
  • Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma.
  • This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.
  • [MeSH-minor] Adenocarcinoma. Aged. Anal Canal / pathology. Anus Neoplasms. Humans. Male

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  • (PMID = 16794808.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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55. Carpentier H, Maizlin I, Bliss D: Anal canal duplication: case reviews and summary of the world literature. Pediatr Surg Int; 2009 Oct;25(10):911-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal duplication: case reviews and summary of the world literature.
  • Anal canal duplication (ACD) is a rare entity that is difficult to recognize.
  • [MeSH-minor] Adolescent. Anal Canal / abnormalities. Child. Child, Preschool. Female. Humans. Incidental Findings. Infant. Infant, Newborn. Male. Young Adult

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  • (PMID = 19727768.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 16
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56. Elbanna HG, Abbas AM, Zalata K, Farid M, Ghanum W, Youssef M, Thabet WM, El Awady S, El-Sattar MH: Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women. Int J Colorectal Dis; 2010 Apr;25(4):477-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of ovarian failure on submucosal collagen and blood vessels of the anal canal in postmenopausal women.
  • BACKGROUND: Estrogen and progesterone receptors are expressed in the anal canal.
  • AIM OF WORK: To study the effects of estrogen and progesterone on inflammatory cells, submucosal collagen fibers, and vascular plexus of the anal canal of postmenopausal women.
  • CONCLUSION: Estrogen and progesterone, in menstruating women, produce beneficial effects by decreasing incidence of inflammation and increasing anal canal submucosal blood vessels number and collagen types I, thus both hormones have a positive effect on anal compliance and pressure.
  • [MeSH-major] Anal Canal / blood supply. Anal Canal / metabolism. Blood Vessels. Collagen Type I / analysis. Ovary / physiopathology. Postmenopause / physiology

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  • (PMID = 19902226.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Estrogens; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 4G7DS2Q64Y / Progesterone
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57. Chang GJ, Gonzalez RJ, Skibber JM, Eng C, Das P, Rodriguez-Bigas MA: A twenty-year experience with adenocarcinoma of the anal canal. Dis Colon Rectum; 2009 Aug;52(8):1375-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A twenty-year experience with adenocarcinoma of the anal canal.
  • PURPOSE: Adenocarcinoma of the anal canal is a rare malignancy with limited data regarding treatment and outcomes.
  • The purpose of this study is to evaluate disease control and survival outcomes in patients with adenocarcinoma of the anal canal.
  • METHODS: A retrospective consecutive cohort study of all patients in whom adenocarcinoma of the anal canal was diagnosed between 1983 and 2004 was performed.
  • Tumor, patient, and treatment characteristics were categorized.
  • Tumor grade was predictive of overall survival (P = 0.04) and recurrence (P = 0.046).
  • CONCLUSION: Combined modality treatment with radical surgical resection improves survival among patients with adenocarcinoma of the anal canal, but a high risk for distant failure emphasizes the need for effective adjuvant therapeutic regimens.
  • [MeSH-major] Adenocarcinoma / epidemiology. Anus Neoplasms / epidemiology
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate / trends. Texas / epidemiology. Time Factors

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  • (PMID = 19617747.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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58. Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr: Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal. World J Gastroenterol; 2009 Jul 28;15(28):3560-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal.
  • Primary neoplasms arising in the anal canal are relatively unusual.
  • We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.
  • This was further evaluated under anesthesia and complete excision of distal anal tissue was performed.
  • Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Anal Canal / pathology

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  • (PMID = 19630115.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2715986
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59. Firat O, Karaköse Y, Calişkan C, Makay O, Ozütemiz O, Korkut MA: Dieulafoy's lesion of the anal canal: report of a case. Turk J Gastroenterol; 2007 Dec;18(4):265-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dieulafoy's lesion of the anal canal: report of a case.
  • BACKGROUND/AIMS: Dieulafoy's lesion of the anal canal is a very rare clinical case.
  • METHODS: Herein, we report one case presenting with massive hematochezia requiring multiple blood transfusions due to a Dieulafoy's lesion in the anal canal.
  • Surgical oversewing was attempted twice but rebleeding occurred, and local excision through the anal canal was performed.

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  • (PMID = 18080926.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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60. Yamaguchi K, Kiyokawa J, Akita K: Developmental processes and ectodermal contribution to the anal canal in mice. Ann Anat; 2008;190(2):119-28

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Developmental processes and ectodermal contribution to the anal canal in mice.
  • The anorectal canal has two origins; the upper part is derived from endoderm and the lower part is derived from ectoderm.
  • The process of ectodermal contribution to the canal remains unclear.
  • Thus, the whole canal was of endodermal origin.
  • After it straightened out and formed the canal, the secondary perineum appeared caudally.
  • During these processes, the external sphincter appeared in the underlying mesenchyme of the thick ectoderm and functioned as a drawstring to form the ectodermal anal canal.
  • [MeSH-major] Anal Canal / embryology. Ectoderm / growth & development

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  • (PMID = 18413265.001).
  • [ISSN] 0940-9602
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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61. Nigri GR, Dente M, Valabrega S, Aurello P, D'Angelo F, Montrone G, Ercolani G, Ramacciato G: Gastrointestinal stromal tumor of the anal canal: an unusual presentation. World J Surg Oncol; 2007;5:20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal stromal tumor of the anal canal: an unusual presentation.
  • GIST of the anal canal are extremely rare.
  • GIST arising from the anal canal account for only 2%-8% of the anorectal GIST.
  • Thus anal GIST must be considered an exceptional case.
  • CASE PRESENTATION: A 78-year-old man was referred to our Institution for an anal mass, in absence of any symptom.
  • An histological diagnosis of a low grade GIST was made.
  • CONCLUSION: At the moment, only ten cases of c-kit positive anal GIST are reported in the literature.
  • These few data are not sufficient to establish a widely accepted approach for this neoplasia.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Anus Neoplasms / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery
  • [MeSH-minor] Aged. Biopsy, Needle. Endosonography. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Staging. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17306018.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1821025
  • [General-notes] NLM/ Original DateCompleted: 20070810
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62. Tiryaki T, Senel E, Atayurt H: Anal canal duplication in children: a new technique. Pediatr Surg Int; 2006 Jun;22(6):560-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal duplication in children: a new technique.
  • Anal canal duplication (ACD) is a very rare abnormality.
  • Because of the high rate of malignant changes in anal canal duplications complete removal of the ACD is recommended.
  • [MeSH-major] Anal Canal / abnormalities. Anal Canal / surgery. Digestive System Abnormalities / surgery

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  • [Cites] Pediatr Surg Int. 2002 Mar;18(2-3):195-7 [11956798.001]
  • [Cites] Pediatr Surg Int. 2001;17(1):45-7 [11294268.001]
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  • (PMID = 16538439.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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63. Damin DC, Tolfo GC, Rosito MA, Spiro BL, Kliemann LM: Sentinel lymph node in patients with rectal cancer invading the anal canal. Tech Coloproctol; 2010 Jun;14(2):133-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sentinel lymph node in patients with rectal cancer invading the anal canal.
  • BACKGROUND: To assess the feasibility of the sentinel lymph node procedure in patients with rectal cancer extending to the anal canal.
  • METHODS: Between January 2005 and April 2008, 15 patients with adenocarcinoma of the rectum with direct invasion of the anal canal and no clinical evidence of inguinal involvement were prospectively enrolled in the study.
  • Although this technique can be potentially useful for a subgroup of patients with isolated inguinal metastases, it cannot be routinely recommended for patients with rectal tumors invading the anal canal at this moment.
  • [MeSH-major] Adenocarcinoma / secondary. Anal Canal. Inguinal Canal. Rectal Neoplasms / pathology. Sentinel Lymph Node Biopsy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Feasibility Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Predictive Value of Tests. Prospective Studies

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  • (PMID = 20424879.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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64. Kounalakis N, Artinyan A, Smith D, Mojica-Manoso P, Paz B, Lai LL: Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal. Ann Surg Oncol; 2009 May;16(5):1310-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal.
  • BACKGROUND: There remains a lack of consensus regarding the optimal treatment for patients with curable adenocarcinoma of the anal canal (AAC).
  • [MeSH-major] Adenocarcinoma / surgery. Anus Neoplasms / surgery. Colectomy / methods

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  • (PMID = 19241106.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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65. Gurzu S, Jung J, Azamfirei L, Mezei T, Cîmpean AM: The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas. Rom J Morphol Embryol; 2007;48(4):349-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas.
  • AIM: To compare the angiogenesis in anal canal carcinomas (ACC) with that in colorectal carcinomas (CRC).
  • [MeSH-major] Anus Neoplasms / blood supply. Anus Neoplasms / pathology. Colorectal Neoplasms / blood supply. Colorectal Neoplasms / pathology. Neovascularization, Pathologic / pathology
  • [MeSH-minor] Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Humans. Immunohistochemistry. Neoplasm Staging

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  • (PMID = 18060184.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
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66. Kobayashi H, Ueno H, Hashiguchi Y, Ishiguro M, Omata J, Kajiwara Y, Shimazaki H, Mochizuki H: T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma. Jpn J Clin Oncol; 2006 May;36(5):325-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma.
  • Neuroendocrine carcinomas of the anal canal are rare, representing 1% of malignant tumors of the anal canal.
  • This tumor behaves aggressively and leads to poor outcomes.
  • We describe the case of a 63-year-old female with T1 neuroendocrine carcinoma of the anal canal arising from the site of a previous transanal excision performed 13 months earlier for intramucosal adenocarcinoma of the anal canal.
  • In this case, it is likely that the neuroendocrine tumor, which infiltrated into the submucosal layer with venous invasion, had developed over the intervening 13 months following the original transanal excision of the adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Anus Neoplasms / etiology. Carcinoma, Neuroendocrine / etiology. Neoplasm Recurrence, Local
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16702164.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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67. Fayaz S, Vasishta S, Motawy M: Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. Gulf J Oncolog; 2007 Jul;(2):65-8
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  • [Title] Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy.
  • A fifty-two years old Egyptian lady, case of cloacogenic carcinoma of anal canal with extensive liver metastasis showed complete remission with 5-Fluorouracil (5FU) and Cis-Dichlorodiammineplatinum(CDDP) chemotherapy only and remains disease free five & haf years after therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma, Squamous Cell / drug therapy. Liver Neoplasms / drug therapy. Survivors

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  • (PMID = 20084726.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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68. Selvasekar C, Suwanthanma W, Nivatvongs S, Hassan I: Local anesthesia of upper anal canal for multiple rubber band ligation: description of technique and preliminary results. Dis Colon Rectum; 2007 Sep;50(9):1481-3
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  • [Title] Local anesthesia of upper anal canal for multiple rubber band ligation: description of technique and preliminary results.
  • PURPOSE: Symptoms caused by hemorrhoids are worse during defecation because of relaxation of the anal canal causing prolapse.
  • We reviewed our experience of multiple rubber band ligations in a relaxed state of the anal canal using local anesthesia.
  • METHODS: Forty-five patients, the majority of whom had Grade 2 or 3 symptomatic hemorrhoids, who required treatment underwent four quadrant local anesthetic infiltration in the submucosa of the upper anal canal.
  • RESULTS: The exposure of the relaxed anal canal was excellent, allowing multiple introductions of the anoscope and application of multiple bands without discomfort.
  • CONCLUSIONS: Local anesthesia of the upper anal canal results in full relaxation and maximal mucosal redundancy of the anal canal simulating the anus in a natural condition during defecation.
  • This gives an excellent exposure of the anal canal, enabling an accurate and multiple applications of rubber bands without pain during and shortly after the procedure.
  • [MeSH-major] Anal Canal / surgery. Anesthesia, Local / methods. Hemorrhoids / surgery. Vascular Surgical Procedures / methods

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  • (PMID = 17665256.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Farid M, El Nakeeb A, Youssef M, Omar W, Fouda E, Youssef T, Thabet W, Elmoneum HA, Khafagy W: Idiopathic hypertensive anal canal: a place of internal sphincterotomy. J Gastrointest Surg; 2009 Sep;13(9):1607-13
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  • [Title] Idiopathic hypertensive anal canal: a place of internal sphincterotomy.
  • BACKGROUND: Hypertensive anal canal is frequently known to be associated with the presence of anal fissure.
  • Based on clinical experience, we hypothesized that idiopathic anal sphincter hypertonia was a condition equivalent to anal fissure, and therefore, it could be treated the same way.
  • PATIENT AND METHODS: Sixty-three patients complaining of anal pain without any anal pathology and ten healthy volunteers were examined.
  • All patients with hypertensive anal canal were randomized into three groups.
  • RESULTS: The mean resting anal pressure (MRAP) was significantly higher in the patient group (114.6 +/- 7.4 mmHg) than control group (72.5 +/- 6.6 mmHg, P < 0.001).
  • Anal pain is the main presenting symptoms aggravated by defecation and not relived by analgesics or local anesthetics.
  • CONCLUSION: Idiopathic hypertensive anal canal is a fact and already exists presented by anal pain aggravated by defecation.

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  • (PMID = 19517198.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.69 / Botulinum Toxins; G59M7S0WS3 / Nitroglycerin
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70. Rizk DE, Hassan HA, Ramadan GA, Shafiullah M, Fahim MA: Estrogen and ghrelin increase number of submucosal urethral and anal canal blood vessels in ovariectomized rats. Urology; 2005 Dec;66(6):1343-8
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  • [Title] Estrogen and ghrelin increase number of submucosal urethral and anal canal blood vessels in ovariectomized rats.
  • This study investigates whether administration of estrogen and/or the anti-aging growth hormone-releasing peptide, ghrelin, improves the adverse effects of menopause/aging on urethral and anal canal submucosal blood vessel counts in middle-age rats.
  • Submucosal blood vessels were counted by light microscopy in five randomly selected fields from five nonconsecutive sections (5 microm thick) per rat of formalin-fixed and paraffin-embedded tissue blocks of the urethra and anal canal stained with hematoxylin-eosin.
  • RESULTS: Ovariectomy significantly reduced submucosal urethral and anal vascular counts below the sham values (7.41 +/- 0.98 versus 5.46 +/- 0.82, P = 0.003 and 7.16 +/- 1.11 versus 4.92 +/- 0.65, P = 0.0009, respectively).
  • Estrogen, ghrelin, and combined estrogen and ghrelin administration also restored the anal counts to sham levels (7.26 +/- 0.97, P = 0.8; 6.56 +/- 0.78, P = 0.3; and 7.76 +/- 0.88, P = 0.3, respectively).
  • CONCLUSIONS: Combined or individual replacement of estrogen and ghrelin produces a beneficial effect by reversing the ovariectomy-induced decrease in urethral and anal canal submucosal vessel numbers in middle-age rats.
  • [MeSH-major] Anal Canal / blood supply. Estrogens / pharmacology. Neovascularization, Physiologic / drug effects. Ovariectomy. Peptide Hormones / pharmacology. Urethra / blood supply

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  • (PMID = 16360481.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogens; 0 / Ghrelin; 0 / Peptide Hormones
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71. Véo CA, Saad SS, Nicolau SM, Melani AG, Denadai MV: Study on the prevalence of human papillomavirus in the anal canal of women with cervical intraepithelial neoplasia grade III. Eur J Obstet Gynecol Reprod Biol; 2008 Sep;140(1):103-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Study on the prevalence of human papillomavirus in the anal canal of women with cervical intraepithelial neoplasia grade III.
  • OBJECTIVE: The objective was to evaluate the prevalence of human papillomavirus (HPV) in the anal canal of women with cervical intraepithelial neoplasia (CIN) grade III.
  • The women in group I who presented high-grade neoplasia in colpocytological tests underwent collection of material from the uterine cervix and anal canal for investigating HPV DNA using the Hybrid Capture II technique.
  • RESULTS: In group I, 39 women (97.5%) were positive for HPV in the uterine cervix and 14 women (35%) in the anal canal.
  • In group II, only four women (10%) had a positive HPV test, for both the uterine cervix and the anal canal.
  • CONCLUSIONS: The prevalence of HPV in the anal canal of the women with CIN III was greater than in the women without CIN III.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Anal Canal / virology. Cervical Intraepithelial Neoplasia / virology. Papillomavirus Infections / epidemiology. Uterine Cervical Neoplasms / virology

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  • (PMID = 18472205.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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72. Stojanović S, Radosević-Jelić I, Dabić-Stanković K, Popov I, Josifovski J: External beam radiotherapy plus brachytherapy boost in treatment of anal canal carcinoma. Acta Chir Iugosl; 2007;54(3):33-8
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  • [Title] External beam radiotherapy plus brachytherapy boost in treatment of anal canal carcinoma.
  • PURPOSE: Radiotherapy has been the standard treatment of anal canal carcinoma for the last three decades.
  • MATERIAL AND METHODS: At the Institute for Oncology and Radiology of Serbia, between March 1997 and May 2004, patients with anal canal carcinoma were treated with combined external beam radiotherapy and brachytherapy boost as primary treatment modality.
  • Total tumor dose in combined radiotherapy treatment ranged from 55-70 Gy.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Brachytherapy

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  • (PMID = 17988027.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Serbia and Montenegro
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73. Tzathas C, Stavrianeas NG, Triantafyllou K, Triantafyllou G, Ladas SD: Long-term follow-up of endoscopic therapy of anal canal condylomata acuminata with podophyllotoxin. J Eur Acad Dermatol Venereol; 2007 Mar;21(3):364-7
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  • [Title] Long-term follow-up of endoscopic therapy of anal canal condylomata acuminata with podophyllotoxin.
  • BACKGROUND: Condylomata acuminata of the anal canal, a common sexually transmitted disease, are difficult-to-treat lesions with a high recurrence rate after initial successful treatment.
  • OBJECTIVE: Our aim was to evaluate by anoscopy the efficacy of podophyllotoxin 0.5% solution topically applied for the treatment of anal warts.
  • METHODS: We prospectively studied consecutive patients with condylomata acuminata of the anal canal that spared the rectum.
  • CONCLUSIONS: Endoscopic topical application of 0.5% podophyllotoxin solution is an effective and well-tolerated method for the treatment of condylomata acuminata of the anal canal.
  • [MeSH-minor] Adolescent. Adult. Anal Canal. Female. Follow-Up Studies. Humans. Male. Middle Aged. Proctoscopy. Prospective Studies. Treatment Outcome

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  • (PMID = 17309460.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Keratolytic Agents; L36H50F353 / Podophyllotoxin
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74. Chetty R, Serra S, Hsieh E: Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant. Am J Surg Pathol; 2005 Dec;29(12):1668-72
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  • [Title] Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant.
  • Two cases of a distinctive variety of basaloid squamous carcinoma (BSC) of the anal canal are described.
  • However, the microscopic pattern was dominated by the presence of eosinophilic, hyaline, paucicellular basement membrane-like material around and within tumor nests.
  • The tumor cells exhibited diffuse nuclear positivity with p63.
  • BSC of the anal canal with an adenoid cystic pattern is an infrequently encountered and reported variant, although it is seen more often in the aerodigestive tract.
  • The histologic differential diagnosis is true salivary gland-type adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Immunohistochemistry and awareness of this unusual pattern of BSC will facilitate the correct diagnosis being reached.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Basosquamous / pathology
  • [MeSH-minor] Antibiotics, Antineoplastic / therapeutic use. Antigens, CD20 / metabolism. Antimetabolites, Antineoplastic / therapeutic use. Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Cisplatin / therapeutic use. DNA-Binding Proteins. Female. Fluorouracil / therapeutic use. Follow-Up Studies. Genes, Tumor Suppressor. Humans. Immunohistochemistry. Keratins / metabolism. Middle Aged. Mitomycin / therapeutic use. Phosphoproteins / metabolism. Radiotherapy. Time Factors. Trans-Activators / metabolism. Transcription Factors. Treatment Outcome. Tumor Burden. Tumor Suppressor Proteins

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  • (PMID = 16327441.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, CD20; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 50SG953SK6 / Mitomycin; 68238-35-7 / Keratins; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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75. Salama JK, Mell LK, Schomas DA, Miller RC, Devisetty K, Jani AB, Mundt AJ, Roeske JC, Liauw SL, Chmura SJ: Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience. J Clin Oncol; 2007 Oct 10;25(29):4581-6
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  • [Title] Concurrent chemotherapy and intensity-modulated radiation therapy for anal canal cancer patients: a multicenter experience.
  • PURPOSE: To report a multicenter experience treating anal canal cancer patients with concurrent chemotherapy and intensity-modulated radiation therapy (IMRT).
  • PATIENTS AND METHODS: From October 2000 to June 2006, 53 patients were treated with concurrent chemotherapy and IMRT for anal squamous cell carcinoma at three tertiary-care academic medical centers.
  • CONCLUSION: Preliminary outcomes suggest that concurrent chemotherapy and IMRT for anal canal cancers is effective and tolerated favorably compared with historical standards.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / drug therapy. Anus Neoplasms / radiotherapy. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Radiotherapy, Intensity-Modulated / methods

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  • [CommentIn] J Clin Oncol. 2008 Feb 1;26(4):688; author reply 688-9 [18235135.001]
  • [ErratumIn] J Clin Oncol. 2008 Feb 1;26(4):694
  • (PMID = 17925552.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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76. Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G: Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice. Cell Cycle; 2010 Aug 1;9(15):3039-45
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  • [Title] Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice.
  • One possibility is that the abrupt transition of the simple columnar epithelium of the colon to the stratified squamous epithelium of the proximal portion of the anal canal may contain a unique stem cell niche.
  • We utilized a tetracycline-regulatable histone H2B-GFP transgenic mice model, previously used to identify hair follicle stem cells, to fluorescently label slow-cycling anal epithelial cells (e.g., prospective stem cells) in combination with a panel of putative stem cell markers.
  • We identified a population of long-term GFP label-retaining cells concentrated at the junction between the anal canal and the rectum.
  • Moreover, tracking the fate of the anal label-retaining cells in vivo revealed that the slow-cycling cells only gave rise to progeny of the anal epithelium.
  • In conclusion, we identified a unique population of cells at the anorectal junction which can be separated from the other basal anal epithelial cells based upon the expression of the stem cell marker CD34 and integrin alpha6, and thus represent a putative anal stem cell population.

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  • (PMID = 20647777.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK078392; United States / NIDDK NIH HHS / DK / P30 DK 078392
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Histones; 147336-22-9 / Green Fluorescent Proteins; G34N38R2N1 / Bromodeoxyuridine
  • [Other-IDs] NLM/ PMC3040928
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77. de la Portilla F, López-Alonso M: Endosonography of the anal canal: findings in children. Dis Colon Rectum; 2009 Apr;52(4):711-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endosonography of the anal canal: findings in children.
  • The thickness of the anal canal of the internal and external anal sphincter of each child was registered and correlated with the age.
  • RESULTS: At the high level, the puborectalis muscles were clearly visualized, with a median thickness of 4.73 mm, and the internal anal sphincters were observed, with a mean thickness of 1.21 mm.
  • At the mid level, both the internal and external anal sphincters were visualized, as well.
  • The mean internal anal sphincter thickness was 1.23 mm and the median thickness of the external anal sphincter was 4.47 mm.
  • At the lower level, the median external anal sphincter thickness was 5.39 mm.
  • The puborectalis and the external anal sphincter thickness showed a highly significant positive correlation with age.
  • We detected a significant increase in the thickness of the external anal sphincter as patients grow older, but not in the internal anal sphincter.
  • [MeSH-major] Anal Canal / anatomy & histology. Anal Canal / ultrasonography. Endosonography

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  • (PMID = 19404079.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Joshi M, Singh S, Vyas T, Chourishi V, Jain A: Mayer-Rokitansky-Kuster-Hauser syndrome and anal canal stenosis: case report and review of literature. J Pediatr Surg; 2010 Dec;45(12):e29-31
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  • [Title] Mayer-Rokitansky-Kuster-Hauser syndrome and anal canal stenosis: case report and review of literature.
  • To the best of our knowledge, there have not been any reported cases of anal canal stenosis in patients with MRKH.
  • We describe a very rare association of MRKH with anal canal stenosis and multiple renal calculi.
  • [MeSH-major] Anal Canal / abnormalities. Kidney Calculi / etiology. Surgically-Created Structures. Vagina / surgery

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21129528.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] Mullerian aplasia
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79. Rouquie D, Lasser P, Castaing M, Boige V, Goéré D, Pignon JP, Ducreux M, Elias D, Pocard M: [Complete (R0) resection is the only valid prognostic factor in abdominoperineal resection for recurrent cancer of the anal canal (a consecutive series of 95 patients)]. J Chir (Paris); 2008 Jul-Aug;145(4):335-40
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  • [Title] [Complete (R0) resection is the only valid prognostic factor in abdominoperineal resection for recurrent cancer of the anal canal (a consecutive series of 95 patients)].
  • [Transliterated title] Résection R0, seul facteur pronostique dans les amputations abdominopérinéales de rattrapage des cancers du canal anal (série consécutive de 95 patients).
  • INTRODUCTION: When radiation therapy fails to control cancer of the anal canal, the only therapeutic alternative is salvage abdomino-perineal resection (APR).
  • CONCLUSION: When anal cancer recurs after radiation therapy, a salvage APR is indicated.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18955923.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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80. Vieillot S, Azria D, Lemanski C, Moscardo CL, Gourgou S, Dubois JB, Aillères N, Fenoglietto P: Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensity-modulated radiation therapy (IMRT) in anal canal cancer. Radiat Oncol; 2010;5:92
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  • [Title] Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensity-modulated radiation therapy (IMRT) in anal canal cancer.
  • BACKGROUND: To compare volumetric-modulated arc therapy (RapidArc) plans with conventional intensity-modulated radiation therapy (IMRT) plans in anal canal cancers.
  • METHODS: Ten patients with anal canal carcinoma previously treated with IMRT in our institution were selected for this study.
  • CONCLUSION: For patients suffering from anal canal cancer, RapidArc with 2 arcs was able to deliver equivalent treatment plan to IMRT in terms of PTV coverage.
  • [MeSH-major] Anus Neoplasms / radiotherapy. Carcinoma / radiotherapy. Organs at Risk / radiation effects. Radiotherapy Planning, Computer-Assisted / methods
  • [MeSH-minor] Humans. Neoplasm Staging. Radiometry. Radiotherapy, Intensity-Modulated

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  • (PMID = 20942958.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2965153
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81. Noakes KF, Bissett IP, Pullan AJ, Cheng LK: Anatomically based computational models of the male and female pelvic floor and anal canal. Conf Proc IEEE Eng Med Biol Soc; 2006;1:3815-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anatomically based computational models of the male and female pelvic floor and anal canal.
  • The understanding of the pelvic floor and anal canal, in the study of incontinence, has been limited by the inability to integrate both anatomy and physiology into a unified bioengineering model.
  • In this study we construct three-dimensional anatomically realistic models of both the male and female pelvic floor and anal canal regions using similar techniques to those used in cardiac modelling.
  • [MeSH-major] Anal Canal / anatomy & histology. Pelvic Bones / anatomy & histology. Pelvis / anatomy & histology. Urinary Incontinence / diagnosis. Visible Human Projects

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  • (PMID = 17945803.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK64775
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Noakes KF, Bissett IP, Pullan AJ, Cheng LK: Anatomically realistic three-dimensional meshes of the pelvic floor & anal canal for finite element analysis. Ann Biomed Eng; 2008 Jun;36(6):1060-71
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  • [Title] Anatomically realistic three-dimensional meshes of the pelvic floor & anal canal for finite element analysis.
  • Three anatomically realistic meshes, suitable for finite element analysis, of the pelvic floor and anal canal regions have been developed to provide a framework with which to examine the mechanics, via finite element analysis of normal function within the pelvic floor.

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  • (PMID = 18317929.001).
  • [ISSN] 1573-9686
  • [Journal-full-title] Annals of biomedical engineering
  • [ISO-abbreviation] Ann Biomed Eng
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK064775; United States / NIDDK NIH HHS / DK / R01 DK64775
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS579936; NLM/ PMC4086924
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83. Lê LH, Chetty R, Moore MJ: Epidermal growth factor receptor expression in anal canal carcinoma. Am J Clin Pathol; 2005 Jul;124(1):20-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal growth factor receptor expression in anal canal carcinoma.
  • Most anal canal carcinomas (ACCs) are squamous cell carcinomas (SCCs).
  • SCCs in other tumor sites strongly express epidermal growth factor receptors (EGFRs), the inhibition of which might result in favorable changes in tumor growth.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / metabolism. Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / metabolism. Receptor, Epidermal Growth Factor / biosynthesis

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  • (PMID = 15923158.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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84. Ikenaga M, Miyazaki M, Yasui M, Mishima H, Tsujie M, Miyamoto A, Hirao M, Fujitani K, Nakamori S, Yoshitatsu S, Tsujinaka T: [A case of total pelvic exenteration and reconstruction of perianal skin defect using a VY advancement of bilateral gluteus maximus musculocutaneous flaps for anal canal cancer associated with anal fistula]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2650-2
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  • [Title] [A case of total pelvic exenteration and reconstruction of perianal skin defect using a VY advancement of bilateral gluteus maximus musculocutaneous flaps for anal canal cancer associated with anal fistula].
  • A 53-year-old man, who was diagnosed as having an anal canal cancer associated with anal fistula, was introduced to our hospital.
  • This constructive technique was effective for anal defects.
  • [MeSH-major] Anus Neoplasms / surgery. Pelvic Exenteration. Rectal Fistula / surgery. Surgical Flaps

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  • (PMID = 21224668.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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85. Mullen JT, Rodriguez-Bigas MA, Chang GJ, Barcenas CH, Crane CH, Skibber JM, Feig BW: Results of surgical salvage after failed chemoradiation therapy for epidermoid carcinoma of the anal canal. Ann Surg Oncol; 2007 Feb;14(2):478-83
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  • [Title] Results of surgical salvage after failed chemoradiation therapy for epidermoid carcinoma of the anal canal.
  • BACKGROUND: The standard treatment for epidermoid carcinoma of the anal canal consists of combined radiation and chemotherapy.
  • Factors that were not found to have an impact on survival included the presence of persistent versus recurrent disease, tumor (T) stage, and margin status of resection.
  • CONCLUSIONS: Long-term survival following salvage surgery for persistent or locally recurrent epidermoid carcinoma of the anal canal can be achieved in the majority of patients.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma, Squamous Cell / therapy. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery

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  • (PMID = 17103253.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Tjandra JJ, Tan JJ, Lim JF, Murray-Green C, Kennedy ML, Lubowski DZ: Rectogesic (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures. Colorectal Dis; 2007 Jun;9(5):457-63
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  • [Title] Rectogesic (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures.
  • OBJECTIVE: Some haemorrhoids are associated with high resting anal canal pressures.
  • The aim of this study was to assess if Rectogesic, a topical glyceryl trinitrate 0.2% ointment was effective in relieving symptoms of early grade haemorrhoids associated with high resting anal canal pressures.
  • Patients with first or second degree haemorrhoids and a maximum resting anal canal pressure > 70 mmHg were included.
  • This recorded the incidence of rectal bleeding, and visual analogue scales for anal pain, throbbing, pruritus, irritation and difficulty in bowel movement.
  • RESULTS: Maximum resting anal canal pressures were reduced after application of Rectogesic (115.0 +/- 40.4 mmHg vs 94.7 +/- 34.1 mmHg, P < 0.001).
  • In the study period and at 14 days after cessation of Rectogesic, there was significant reduction in rectal bleeding (P = 0.0002), and significant improvement of anal pain (P = 0.0024), throbbing (P = 0.0355), pruritus (P = 0.0043), irritation (P = 0.0000) and difficulty in bowel movement (P = 0.001).
  • CONCLUSION: Rectogesic is a safe and feasible treatment for patients with early grade haemorrhoids associated with high resting anal canal pressures.
  • [MeSH-minor] Adult. Aged. Anal Canal / drug effects. Anal Canal / physiopathology. Female. Humans. Male. Manometry. Middle Aged. Ointments. Prospective Studies. Severity of Illness Index

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  • [CommentIn] Colorectal Dis. 2008 Jan;10(1):96 [17645569.001]
  • (PMID = 17504344.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ointments; 0 / Vasodilator Agents; G59M7S0WS3 / Nitroglycerin
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87. Ciriza-de-Los-Ríos C, Ruiz-de-León-San-Juan A, Díaz-Rubio García M, Tomás-Moros E, García-Durán F, Muñoz-Yagüe T, Canga-Rodríguez-Valcárcel F, Gómez-de-la-Cámara A, Castellano-Tortajada G: Differences in the pressures of canal anal and rectal sensitivity in patients with fecal incontinence, chronic constipation and healthy subjects. Rev Esp Enferm Dig; 2010 Dec;102(12):683-90
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  • [Title] Differences in the pressures of canal anal and rectal sensitivity in patients with fecal incontinence, chronic constipation and healthy subjects.
  • INTRODUCTION: There exists a great variability in the manometric findings between patients with anal incontinence (AI) and healthy subjects.
  • The correlation between the pressures of the anal canal and the AI is not exact by the wide rank of normal values.
  • OBJECTIVES: Prospective study to evaluate differences in the pressures of the anal canal and in rectal sensitivity in patients with AI, chronic constipation (CC) and healthy subjects.
  • The following data were obtained: age, sex, resting pressure, anal canal length (ACL), squeeze maximum pressure (SMP), squeeze pressure duration (SPD), first sensation, urge and maximum tolerated volume (MTV).
  • CONCLUSIONS: The greater age, the decrease in anal canal resting pressure and the alteration of rectal sensation increase the risk for AI.
  • [MeSH-major] Anal Canal / physiology. Constipation / physiopathology. Fecal Incontinence / physiopathology. Rectum / physiology

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  • [CommentIn] Rev Esp Enferm Dig. 2010 Dec;102(12):679-82 [21198308.001]
  • (PMID = 21198309.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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88. Schiller DE, Cummings BJ, Rai S, Le LW, Last L, Davey P, Easson A, Smith AJ, Swallow CJ: Outcomes of salvage surgery for squamous cell carcinoma of the anal canal. Ann Surg Oncol; 2007 Oct;14(10):2780-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcomes of salvage surgery for squamous cell carcinoma of the anal canal.
  • BACKGROUND: For patients with anal canal cancer who fail combined modality treatment (CMT), salvage surgery (SS) offers the potential for long term survival.
  • METHODS: We identified 60 patients with persistent or recurrent anal cancer who had undergone SS; 20 were excluded.
  • Independent predictors of poor OS were male gender, Charlson Comorbidity Score and tumor size.
  • CONCLUSION: SS for anal canal cancer was associated with significant morbidity.
  • [MeSH-major] Anus Neoplasms / surgery. Carcinoma, Squamous Cell / surgery. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / surgery. Salvage Therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Anal Canal / surgery. Cancer Care Facilities. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Ontario. Registries. Reoperation. Retrospective Studies

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  • (PMID = 17638059.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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89. Deo SV, Shukla NK, Raina V, Mohanti BK, Sharan R, Kar M, Rath GK: Organ-preserving multimodality management of squamous cell carcinoma of anal canal. Indian J Gastroenterol; 2005 Sep-Oct;24(5):201-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Organ-preserving multimodality management of squamous cell carcinoma of anal canal.
  • AIM: To study the efficacy of an organ-preserving, sequential chemoradiation therapy for squamous cell carcinoma of the anal canal, and of salvage surgery in those in whom this treatment fails.
  • METHODS: Forty biopsy-proven untreated patients (28 men) with squamous cell carcinoma of the anal canal received two cycles of chemotherapy using cisplatin and methotrexate, followed by 45 to 60 (median 50) Gy external beam radiotherapy.
  • Three patients had post-treatment anal stenosis requiring repeated dilatation and two had chronic non-healing ulcers at the anal verge.
  • CONCLUSION: Chemoradiation is effective in the treatment of squamous cell anal cancer and has acceptable toxicity.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma, Squamous Cell / therapy
  • [MeSH-minor] Adult. Aged. Anal Canal. Antineoplastic Agents / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cisplatin / therapeutic use. Colostomy. Combined Modality Therapy. Female. Humans. Methotrexate / therapeutic use. Middle Aged. Salvage Therapy

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  • (PMID = 16361764.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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90. Moreau-Claeys MV, Peiffert D: [Normal tissue tolerance to external beam radiation therapy: anal canal]. Cancer Radiother; 2010 Jul;14(4-5):359-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Normal tissue tolerance to external beam radiation therapy: anal canal].
  • [Transliterated title] Dose de tolérance à l'irradiation des tissus sains: le canal anal.
  • The anal canal is regarded as an organ at risk more often in pelvis radiation, but also in brachytherapy.
  • Acute or chronic complications depend on its different components and are different from the anal margin or the rectum.
  • [MeSH-major] Anal Canal / radiation effects. Radiation Tolerance. Radiotherapy / adverse effects. Radiotherapy / methods

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  • [Copyright] Copyright (c) 2010. Published by Elsevier SAS.
  • (PMID = 20418146.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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91. Lee WS, Chun HK, Lee WY, Yun SH, Yun H, Cho YB, Kang WK, Park YS, Huh SJ, Ahn YC, Park W: Anal canal carcinoma: experience from a single Korean institution. Yonsei Med J; 2007 Oct 31;48(5):827-32
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  • [Title] Anal canal carcinoma: experience from a single Korean institution.
  • PURPOSE: The clinical features, treatment modality approaches in clinical practice, and prognostic factors for anal canal carcinoma patients were retrospectively analyzed.
  • MATERIALS AND METHODS: Between October 1994 and December 2005, 50 patients with anal canal cancer were treated at Samsung Medical Center, Seoul, Korea.
  • Univariate analysis showed that tumor size (p=0.04) and inguinal node status (p=0.04) significantly influenced patient survival in patients with squamous cell and cloacogenic carcinomas.
  • Due to the rarity and complexity of anal canal carcinoma, interdepartmental cooperation is required for disease treatment.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma / therapy

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  • [Cites] J Clin Oncol. 1997 May;15(5):2040-9 [9164216.001]
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  • (PMID = 17963341.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2628150
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92. Roohipour R, Patil S, Goodman KA, Minsky BD, Wong WD, Guillem JG, Paty PB, Weiser MR, Neuman HB, Shia J, Schrag D, Temple LK: Squamous-cell carcinoma of the anal canal: predictors of treatment outcome. Dis Colon Rectum; 2008 Feb;51(2):147-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous-cell carcinoma of the anal canal: predictors of treatment outcome.
  • PURPOSE: The incidence of anal canal squamous-cell carcinoma is increasing.
  • METHODS: Using one database, we identified 131 Stages I-III patients treated for primary anal canal squamous-cell carcinoma at our institution from December 1986 to August 2006, with minimum six-month follow-up.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma, Squamous Cell / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Combined Modality Therapy / methods. Disease-Free Survival. Endosonography. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Staging. New York / epidemiology. Retrospective Studies. Survival Rate. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • [ErratumIn] Dis Colon Rectum. 2008 May;51(5):620
  • (PMID = 18180997.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Chiao EY, Krown SE, Stier EA, Schrag D: A population-based analysis of temporal trends in the incidence of squamous anal canal cancer in relation to the HIV epidemic. J Acquir Immune Defic Syndr; 2005 Dec 1;40(4):451-5
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  • [Title] A population-based analysis of temporal trends in the incidence of squamous anal canal cancer in relation to the HIV epidemic.
  • Squamous cell carcinoma of the anal canal (SCCA) is etiologically linked to human papillomavirus, and its incidence is increased among the immunosuppressed.
  • [MeSH-major] Anus Neoplasms / epidemiology. Carcinoma, Squamous Cell / epidemiology. HIV Infections / epidemiology


94. Tomita R, Igarashi S, Fujisaki S: Studies on anal canal sensitivity in patients with or without soiling after low anterior resection for lower rectal cancer. Hepatogastroenterology; 2008 Jul-Aug;55(85):1311-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Studies on anal canal sensitivity in patients with or without soiling after low anterior resection for lower rectal cancer.
  • BACKGROUND/AIMS: Anal canal sensitivity is conducted by the sensory branch of the pudendal nerve.
  • To clarify the significance of the anal canal sensitivity function in patients with soiling after low anterior resection (LAR) for lower rectal cancer, we studied the threshold of anal canal sensitivity using an anal canal sensitivity test (ACST).
  • METHODS: Anal canal sensitivity was measured using an ACST.
  • Measurement points of the anal canal were divided into 2 sites: the portion just on the dentate line (DL) and the portion 1 cm below the DL.
  • The threshold of sensitivity was assessed in the upper, middle, and lower parts of the anal canal.
  • Anal canal sensitivity in patients with soiling was significantly lower than in patients without soiling at both sites (p < 0.0001).
  • Patients with soiling showed the worst results in anal canal sensitivity at the DL.
  • CONCLUSION: The ACST shows significantly lower sensitivity in the anal canal site of DL in patients with soiling after LAR.
  • [MeSH-major] Anal Canal / physiopathology. Fecal Incontinence / physiopathology. Postoperative Complications. Rectal Neoplasms / physiopathology. Sensation / physiology

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  • (PMID = 18795679.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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95. Lepère C, Rakotomalala S, Maindrault-Goebel F, Mitry E, Vaillant JN, Julie C, Otmezguine Y, Rougier P: [Conservative treatment undifferentiated neuroendocrine tumors of the anal canal: two cases]. Gastroenterol Clin Biol; 2007 Apr;31(4):445-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Conservative treatment undifferentiated neuroendocrine tumors of the anal canal: two cases].
  • [Transliterated title] Traitement conservateur des tumeurs endocrines peu différenciées du canal anal.
  • Most patients have metastatic disease at diagnosis, and cannot undergo curative surgical treatment.
  • We report two cases of poorly differentiated neuroendocrine tumors localized in the anal canal and treated by chemotherapy and radiotherapy resulting in prolonged complete local remission and preventing extended surgical excision.
  • [MeSH-major] Anus Neoplasms / therapy. Brain Neoplasms / secondary. Neuroendocrine Tumors / therapy
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Aged. Anal Canal / pathology. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Agents, Phytogenic / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Cisplatin / administration & dosage. Cisplatin / therapeutic use. Combined Modality Therapy. Etoposide / administration & dosage. Etoposide / therapeutic use. Female. Follow-Up Studies. Humans. Male. Radiotherapy Dosage. Remission Induction. Time Factors

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  • (PMID = 17483787.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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96. Cameron IL, Kent JE, Philo R, Barnes CJ, Hardman WE: Numerical distribution of lymphoid nodules in the human sigmoid colon, rectosigmoidal junction, rectum, and anal canal. Clin Anat; 2006 Mar;19(2):164-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Numerical distribution of lymphoid nodules in the human sigmoid colon, rectosigmoidal junction, rectum, and anal canal.
  • There is little information on the numerical distribution of lymphoid nodules (LN) in distal segments of the human large bowel.
  • A novel approach was therefore developed to assess the number of LN in the sigmoid colon, the rectosigmoid segment, the rectum, and the anal canal in humans.
  • The number of LN was scored macroscopically from the proximal sigmoid colon to the distal anal canal.
  • A numerical distribution, previously unreported, consisting of two circular bands of LN was observed in each of the five cadavers.
  • Significantly more LN occurred 3-5 cm proximal to the pectinate line compared to areas distal or proximal to this band of LN.
  • This band of LN has not been reported previously in humans.
  • [MeSH-major] Anal Canal / anatomy & histology. Colon, Sigmoid / anatomy & histology. Lymphoid Tissue / anatomy & histology. Rectum / anatomy & histology

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  • (PMID = 16444704.001).
  • [ISSN] 0897-3806
  • [Journal-full-title] Clinical anatomy (New York, N.Y.)
  • [ISO-abbreviation] Clin Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Balachandra B, Marcus V, Jass JR: Poorly differentiated tumours of the anal canal: a diagnostic strategy for the surgical pathologist. Histopathology; 2007 Jan;50(1):163-74
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  • [Title] Poorly differentiated tumours of the anal canal: a diagnostic strategy for the surgical pathologist.
  • Poorly differentiated malignancies affecting the anal canal are uncommon but pose diagnostic difficulties because of the wide range of normal cell types that may occur within a limited anatomical region.
  • The range of lesions that may present as poorly differentiated tumours includes squamous cell carcinoma, adenocarcinoma, small and large cell neuroendocrine carcinoma, neuroendocrine carcinoma expressing epithelial cytokeratins and other patterns of mixed differentiation, undifferentiated carcinoma, malignant melanoma, lymphoma and secondary tumours.
  • This review discusses the differential diagnosis of these neoplasms with the aid of short illustrative case studies.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Lymphoma / pathology. Male. Melanoma / pathology. Middle Aged. Pathology, Surgical / methods

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  • (PMID = 17204029.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 72
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98. Rabbani AN, Zlotecki RA, Kirwan J, George TJ Jr, Morris CG, Rout WR, Mendenhall WM: Definitive radiotherapy for squamous cell carcinoma of the anal canal. Am J Clin Oncol; 2010 Feb;33(1):47-51
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  • [Title] Definitive radiotherapy for squamous cell carcinoma of the anal canal.
  • PURPOSE: To review the outcomes of definitive radiotherapy (RT) alone or combined with chemotherapy (CT) in the treatment of squamous cell carcinoma of the anal canal.
  • [MeSH-major] Anal Canal / radiation effects. Antineoplastic Agents / therapeutic use. Anus Neoplasms / radiotherapy. Carcinoma, Squamous Cell / radiotherapy. Neoplasm Recurrence, Local / diagnosis
  • [MeSH-minor] Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Neoplasm Staging. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 19704368.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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99. Koga H, Okazaki T, Kato Y, Lane GJ, Yamataka A: Anal canal duplication: experience at a single institution and literature review. Pediatr Surg Int; 2010 Oct;26(10):985-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal duplication: experience at a single institution and literature review.
  • PURPOSE: Anal canal duplication (ACD) is an extremely rare congenital intestinal anomaly.
  • Mean age at diagnosis was 6 months (range 0-47 months).
  • All underwent surgical removal of the anal canal duplication, eight through a perineal approach and two through a posterior sagittal approach, depending on the length of the duplicated anal canal and the presence of concurrent anomalies.
  • Histopathology of the excised anal canals showed squamous epithelium in all cases.
  • [MeSH-major] Anal Canal / abnormalities. Digestive System Abnormalities / surgery. Digestive System Surgical Procedures / methods
  • [MeSH-minor] Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 20668865.001).
  • [ISSN] 1437-9813
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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100. Pérez Pereyra J, Frisancho Velarde O, Ruiz Barahona E, Palomino A: [Fibroepithelial lesions of the anal canal: therapeutic technique with rubber band ligation]. Rev Gastroenterol Peru; 2008 Jan-Mar;28(1):37-42
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  • [Title] [Fibroepithelial lesions of the anal canal: therapeutic technique with rubber band ligation].
  • [Transliterated title] Lesiones Fibroepiteliales del Canal Anal: alternativa terapéutica con ligadura de bandas elásticas.
  • When fibroepithelial lesions of the anal canal increase in size and bleed, they can produce tenesmus and a sensation of a foreign body in the anus.
  • In the Gastroenterology Department of the "Edgardo Rebagliati Martins" National Hospital (EsSALUD) between June 2000, and June, 2007, 16 patients with anal fibroepithelioma were included: 6 men and 10 women, with an average age of 44, aged between 21 to 75, and 44% aged 20 to 29.
  • All of these patients (100%) had anal tumors, 50% had prolapses, 28% had anal pain and, 12% intermittent slight bleeding.
  • Patients only required oral analgesics for the first hours after procedure; only one patient presented an acute anal fissure.
  • [MeSH-major] Anus Neoplasms / therapy. Neoplasms, Fibroepithelial / therapy

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  • (PMID = 18418455.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Peru
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