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1. Shia J: An update on tumors of the anal canal. Arch Pathol Lab Med; 2010 Nov;134(11):1601-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An update on tumors of the anal canal.
  • CONTEXT: The anal canal possesses complex anatomy and histology and gives rise to a variety of tumor types.
  • Challenging issues remain with regard to both the pathologic diagnosis and the clinical management of these tumors.
  • OBJECTIVES: To provide an updated overview of the histogenesis, clinical and pathologic characteristics, diagnostic terminology, and relevant clinical management of the various types of anal canal tumors.
  • DATA SOURCES: Recent literature on clinical and pathologic characteristics of anal canal tumors.
  • CONCLUSIONS: Although most anal canal tumors are of squamous lineage, a complex variety of other tumors also occurs.
  • Recognition of such diverse tumor entities will allow accurate pathologic diagnosis and most optimal clinical management.
  • [MeSH-major] Adenocarcinoma / pathology. Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. Melanoma / pathology

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  • (PMID = 21043813.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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2. Eng C: Anal cancer: current and future methodology. Cancer Invest; 2006 Aug-Sep;24(5):535-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal cancer: current and future methodology.
  • Despite the small number of patients affected by carcinoma of the anal canal it remains one of the most challenging cancers to treat.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Carcinoma in Situ / drug therapy. Carcinoma in Situ / pathology. Carcinoma in Situ / radiotherapy. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiotherapy. Cisplatin / therapeutic use. Clinical Trials as Topic. Fluorouracil / therapeutic use. HIV Infections / complications. Humans. Mitomycin / therapeutic use. Neoadjuvant Therapy. Neoplasm Metastasis. Neoplasm Recurrence, Local. Neoplasm, Residual. Papillomavirus Infections / complications

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  • (PMID = 16939964.001).
  • [ISSN] 0735-7907
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 50SG953SK6 / Mitomycin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
  • [Number-of-references] 64
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3. Garrett K, Kalady MF: Anal neoplasms. Surg Clin North Am; 2010 Feb;90(1):147-61, Table of Contents
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal neoplasms.
  • A variety of lesions comprise tumors of the anal canal, with carcinoma in situ and epidermoid cancers being the most common.
  • Less common anal neoplasms include adenocarcinoma, melanoma, gastrointestinal stromal cell tumors, neuroendocrine tumors, and Buschke-Lowenstein tumors.
  • [MeSH-minor] Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Carcinoma, Verrucous / diagnosis. Carcinoma, Verrucous / pathology. Humans. Intestinal Mucosa / pathology. Neoplasm Recurrence, Local / surgery. Prognosis. Rectal Neoplasms / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20109639.001).
  • [ISSN] 1558-3171
  • [Journal-full-title] The Surgical clinics of North America
  • [ISO-abbreviation] Surg. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 105
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4. Nano M, Ferronato M, Solej M, D'Amico S: T1 adenocarcinoma of the rectum: transanal excision or radical surgery? Tumori; 2006 Nov-Dec;92(6):469-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] T1 adenocarcinoma of the rectum: transanal excision or radical surgery?
  • The stage of the disease at the time of diagnosis is the main prognostic factor in rectal cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Age Factors. Anal Canal / surgery. Colectomy / adverse effects. Humans. Lymphatic Metastasis. Microsurgery. Neoplasm Recurrence, Local. Neoplasm Staging. Patient Selection. Proctoscopy. Prognosis. Risk Factors

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  • (PMID = 17260485.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 59
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5. Amano K, Kumamoto K, Ohsawa T, Okada N, Ishibashi K, Inokuma S, Nakada H, Yokoyama M, Haga N, Ishida H: [The prognosis and immunohistochemical evaluation of five perianal Paget's disease cases]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2653-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Perianal Paget's disease is categorized as Paget's disease, which is epidermotropic neoplasm arising from the apocrine glands of perianal region, or Pagetoid spread invaded from rectal or anal canal cancer.
  • All cases presented the redness around perianal regions, and 2 cases were recognized a tumor at the anal canal.
  • It was compatible with the preoperative diagnosis.
  • Only one of 3 Paget's disease cases was positive for GCDFP15 and negative for CK20 resulting in the diagnosis of perianal Paget's disease.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Biomarkers, Tumor / analysis. Carrier Proteins / analysis. Glycoproteins / analysis. Keratin-20 / analysis. Paget Disease, Extramammary / diagnosis. Paget Disease, Extramammary / pathology

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  • (PMID = 21224669.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / Glycoproteins; 0 / Keratin-20; 0 / PIP protein, human
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6. Schiessel R, Novi G, Holzer B, Rosen HR, Renner K, Hölbling N, Feil W, Urban M: Technique and long-term results of intersphincteric resection for low rectal cancer. Dis Colon Rectum; 2005 Oct;48(10):1858-65; discussion 1865-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Cancers were staged according to the Dukes classification (Stage A in 41 percent, Stage B in 28 percent, and Stage C in 31 percent; median distance from the anal margin, 3 (range, 1-5) cm).
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Carcinoid Tumor / surgery. Colectomy / methods. Rectal Neoplasms / surgery

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  • (PMID = 16086223.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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7. Morris E, Quirke P, Thomas JD, Fairley L, Cottier B, Forman D: Unacceptable variation in abdominoperineal excision rates for rectal cancer: time to intervene? Gut; 2008 Dec;57(12):1690-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / surgery

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  • [CommentIn] Gut. 2009 Jan;58(1):146; author response 146-7 [19091835.001]
  • [CommentIn] Gut. 2009 Jan;58(1):150; author reply 150-2 [19091841.001]
  • [CommentIn] Gut. 2009 Jan;58(1):147; author reply 147-8 [19091837.001]
  • [CommentIn] Gut. 2009 Apr;58(4):608-9; author reply 609-10 [19299392.001]
  • [CommentIn] Gut. 2009 Feb;58(2):311; author reply 311-2 [19136525.001]
  • [CommentIn] Gut. 2010 Jan;59(1):139-40 [20007965.001]
  • [CommentIn] Gut. 2008 Dec;57(12):1643-5 [19022921.001]
  • (PMID = 18535029.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / 9805
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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8. Yumuk PF, Abacioglu U, Demir G, Cabuk D, Dane F, Gumus M, Ozguroglu M, Ekenel M, Basaran G, Turhal NS: Does the incidence of anal canal cancers differ in Moslem societies? Int J Colorectal Dis; 2005 Jan;20(1):76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does the incidence of anal canal cancers differ in Moslem societies?
  • [MeSH-major] Adenocarcinoma / epidemiology. Adenocarcinoma / ethnology. Anus Neoplasms / epidemiology. Anus Neoplasms / ethnology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / ethnology. Hygiene. Islam. Registries / statistics & numerical data

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  • (PMID = 15293063.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] Germany
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9. Chen CC, Leu SY, Liu MC, Jian JJ, Chen CM: Transanal local wide excision for rectal adenocarcinoma. Hepatogastroenterology; 2005 Mar-Apr;52(62):460-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transanal local wide excision for rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Digestive System Surgical Procedures. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Incidence. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Postoperative Care. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 15816457.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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10. Yeo SG, Kim DY, Kim TH, Jung KH, Hong YS, Chang HJ, Park JW, Lim SB, Choi HS, Jeong SY: Tumor volume reduction rate measured by magnetic resonance volumetry correlated with pathologic tumor response of preoperative chemoradiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys; 2010 Sep 1;78(1):164-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma. Magnetic Resonance Imaging / methods. Rectal Neoplasms. Tumor Burden
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / surgery. Analysis of Variance. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy / methods. Female. Humans. Imaging, Three-Dimensional / methods. Male. Middle Aged. Neoplasm Staging / methods. Preoperative Care / methods. Remission Induction / methods. Retrospective Studies

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20004532.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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11. Kim DW, Lim SB, Kim DY, Kim TH, Jung KH, Kim DH, Chang HJ, Sohn DK, Hong CW, Choi HS, Jeong SY, Park JG: Pre-operative chemo-radiotherapy improves the sphincter preservation rate in patients with rectal cancer located within 3 cm of the anal verge. Eur J Surg Oncol; 2006 Mar;32(2):162-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pre-operative chemo-radiotherapy improves the sphincter preservation rate in patients with rectal cancer located within 3 cm of the anal verge.
  • AIMS: To evaluate whether pre-operative chemo-radiotherapy (CRT) improves the sphincter preservation rate for distal rectal cancers within 3 cm of the anal verge.
  • METHODS: Between January 2001 and December 2004, 49 patients underwent surgery with or without pre-operative CRT for primary rectal adenocarcinoma within 3 cm of the anal verge.
  • RESULTS: Of 49 patients with rectal tumours within 3 cm of the anal verge, 31 underwent pre-operative CRT followed by surgery (CRT group), and 18 underwent surgery alone (non-CRT group).
  • CONCLUSION: We could observe that sphincter preservation was improved in CRT group with statistical significance when compared to non-CRT group in our study patients with rectal cancer within 3 cm of the anal verge.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / therapy. Anal Canal / drug effects. Anal Canal / radiation effects. Neoadjuvant Therapy. Rectal Neoplasms / pathology. Rectal Neoplasms / therapy

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  • (PMID = 16289718.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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12. Chanjuan Shi, Argani P: Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon. Int J Surg Pathol; 2009 Feb;17(1):42-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon.
  • Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma.
  • Immunohistochemical stains demonstrated that the Paget's cells were CK7+/ CK20-/GCDFP+, whereas the rectal adenocarcinoma was CK7+(variable)/CK20+/GCDFP-.
  • This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma-to our knowledge a hitherto undocumented occurrence.
  • [MeSH-major] Adenocarcinoma / diagnosis. Anal Canal. Neoplasms, Multiple Primary / diagnosis. Paget Disease, Extramammary / diagnosis. Rectal Neoplasms / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18499687.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Glycoproteins; 0 / Keratin-20; 0 / Keratin-7; 0 / PIP protein, human
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13. Yamauchi M, Okamoto Y, Doi M, Shinozaki K: [mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report]. Gan To Kagaku Ryoho; 2010 Nov;37(11):2209-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [mFOLFOX6 for treatment of anal canal cancer with disseminated carcinomatosis of bone marrow--a case report].
  • There was a hard anal mass on rectal examination.
  • Colonoscopy and computed tomography showed anal adenocarcinoma, multiple metastases to lymph nodes and bones.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Anus Neoplasms / drug therapy. Bone Marrow Neoplasms / drug therapy. Carcinoma / drug therapy

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  • (PMID = 21084829.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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14. Jin Z, Yin L, Xue L, Lin M, Zheng Q: Anorectal functional results after transanal endoscopic microsurgery in benign and early malignant tumors. World J Surg; 2010 May;34(5):1128-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Anorectal manometric values showed the mean anal resting pressure (ARP) decrease from 45 +/- 6 mmHg to 29 +/- 4 mmHg (p < 0.05) and the maximum tolerable volume (MTV) decrease from 175 +/- 21 ml to 90 +/- 15 ml (p < 0.05) at the third month after TEM.
  • Endosonography demonstrated internal anal sphincter (IAS) rupture in five patients, and full integrity of the external anal sphincter (EAS) in all patients.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / physiopathology. Anus Neoplasms / surgery. Rectal Neoplasms / surgery. Rectum / physiopathology

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  • (PMID = 20225126.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Gu J, Li J, Yao Y, Lu A, Wang H: Synchronous rectal adenocarcinoma and anal canal adenocarcinoma. Front Med China; 2007 Jul;1(3):333-7
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  • [Title] Synchronous rectal adenocarcinoma and anal canal adenocarcinoma.
  • It is difficult to distinguish a rectal carcinoma with anal metastases from coexistent synchronous anorectal carcinomas.
  • The therapeutic strategy for rectal and anal carcinoma is so different that it should be clearly identified.
  • Here, we report on the case of a 63-year-old man who presented with an upper-third rectal adenocarcinoma.
  • Five months after resection, he developed an adenocarcinoma in the anal canal.
  • For this reason, we believe the present case had synchronous adenocarcinomas arising from anal canal and the rectum separately.
  • It is very important to differentiate the anorectal lesions pathologically because of the impact on the therapeutic options available, especially for the lesion arising in the anal canal.

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  • (PMID = 24573877.001).
  • [ISSN] 1673-7342
  • [Journal-full-title] Frontiers of medicine in China
  • [ISO-abbreviation] Front Med China
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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16. Owens SR, Greenson JK: Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. Am J Surg Pathol; 2007 Feb;31(2):285-90
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  • [Title] Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas.
  • Anal canal carcinomas account for between 1% and 2% of all gastrointestinal carcinomas in the United States.
  • By far, the most common carcinoma in this site is squamous cell carcinoma, but the differential diagnosis typically includes poorly differentiated adenocarcinoma and well-differentiated neuroendocrine carcinoma or carcinoid tumor.
  • However, accurate diagnosis is imperative, because the treatment differs between squamous carcinoma (chemoradiation) and the other types of carcinoma (surgical therapy).
  • Therefore, we undertook to ascertain its usefulness in the diagnosis of squamous carcinomas in the anal canal.
  • We retrieved 24 anal squamous carcinomas, 68 colorectal adenocarcinomas (including a tissue microarray), and 32 colorectal neuroendocrine carcinomas from the archives at the University of Michigan, and immunostained them for the p63 antigen.
  • It also stained the dysplastic epithelial cells in adjacent areas of anal intraepithelial neoplasia.
  • We report that the p63 immunostain is a highly specific and useful tool in the diagnosis of carcinomas of the anal canal.
  • [MeSH-major] Anal Canal / metabolism. Anus Neoplasms / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / metabolism. DNA-Binding Proteins / metabolism. Immunoenzyme Techniques / methods. Trans-Activators / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Carcinoid Tumor / diagnosis. Carcinoid Tumor / metabolism. Carcinoma in Situ / metabolism. Carcinoma in Situ / pathology. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / metabolism. Colorectal Neoplasms / metabolism. Colorectal Neoplasms / pathology. Diagnosis, Differential. Humans. Predictive Value of Tests. Tissue Array Analysis. Transcription Factors

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  • (PMID = 17255774.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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17. Suenaga M, Oya M, Ueno M, Yamamoto J, Yamaguchi T, Mizunuma N, Hatake K, Kato Y, Muto T: Anal canal carcinoma with Pagetoid spread: report of a case. Surg Today; 2006;36(7):666-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal canal carcinoma with Pagetoid spread: report of a case.
  • A 70-year-old man with a history of colon polyps was found to have a semipedunculated polyp in the anal canal.
  • Histological examination of biopsy specimens revealed well-differentiated adenocarcinoma of the anal canal.
  • Pathological examination of the anal canal carcinoma revealed submucosally invasive well-differentiated adenocarcinoma with a positive distal surgical margin.
  • Pathological examination revealed continuance within the epidermis between the anal canal adenocarcinoma and Paget's cells in the perianal skin lesion.
  • Thus, we concluded that the perianal skin lesion was Pagetoid spread of anal canal adenocarcinoma.
  • This report shows that the perianal skin should be examined carefully in patients with anal canal carcinoma.
  • [MeSH-minor] Adenocarcinoma. Aged. Anal Canal / pathology. Anus Neoplasms. Humans. Male

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  • (PMID = 16794808.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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18. Beattie GC, Paul I, Calvert CH: Endoscopic transanal resection of rectal tumours using a urological resectoscope--still has a role in selected patients. Colorectal Dis; 2005 Jan;7(1):47-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathology revealed rectal adenoma (with varying degrees of dysplasia) in 11 (55%) patients and adenocarcinoma in 9 (45%).
  • The majority (30; 70%) of resections were carried out in patients with benign disease, with 13 (30%) in patients with rectal adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anal Canal / surgery. Proctoscopy. Rectal Neoplasms / surgery. Urologic Surgical Procedures / instrumentation

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  • (PMID = 15606584.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. Gujral DM, Bhattacharyya S, Hargreaves P, Middleton GW: Metastatic rectal adenocarcinoma within haemorrhoids: a case report. J Med Case Rep; 2008;2:128
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic rectal adenocarcinoma within haemorrhoids: a case report.
  • INTRODUCTION: Metastatic tumour involvement of the anal canal is rare.

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  • (PMID = 18442399.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2386132
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20. Chia CS, Chew MH, Chau YP, Eu KW, Ho KS: Adenocarcinoma of the anal transitional zone after double stapled ileal pouch-anal anastomosis for ulcerative colitis. Colorectal Dis; 2008 Jul;10(6):621-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the anal transitional zone after double stapled ileal pouch-anal anastomosis for ulcerative colitis.
  • The development of adenocarcinoma in the anal transitional zone, after restorative proctocolectomy for ulcerative colitis, is rare.
  • Restorative proctocolectomy and stapled ileal pouch-anal anastomosis without mucosectomy was performed.
  • A poorly differentiated adenocarcinoma in the anal transition zone was diagnosed and she subsequently underwent an abdomino-perineal resection.
  • We also discuss the suggested surveillance for high-risk patients who have undergone an ileal-anal pouch anastomosis.
  • [MeSH-major] Adenocarcinoma / etiology. Anal Canal / surgery. Anastomosis, Surgical. Anus Neoplasms / etiology. Colitis, Ulcerative / surgery. Colonic Pouches

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  • (PMID = 17949443.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. Kanoh T, Ohnishi T, Danno K, Watanabe A, Nakamura H, Tsukao Y, Inatome J, Kim C, Kagara N, Taniguchi H, Kimura Y, Tono T, Nakano Y, Monden T, Imaoka S: [A case of successfully treated lower rectal cancer with both inguinal lymph nodes by chemoradiotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2611-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 59-year-old man presented with anal pain.
  • The histological diagnosis was well to moderately differentiated adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / therapy. Lymphatic Metastasis. Rectal Neoplasms / therapy
  • [MeSH-minor] Angiogenesis Inhibitors / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bevacizumab. Combined Modality Therapy. Fluorouracil / therapeutic use. Humans. Ileostomy. Inguinal Canal. Leucovorin / therapeutic use. Male. Middle Aged. Organoplatinum Compounds / therapeutic use. Radiotherapy, Intensity-Modulated

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  • (PMID = 21224655.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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22. Fritsch H, Zehm S, Illig R, Moser P, Aigner F: New insights into the development and differentiation of the human anorectal epithelia. Are there clinical consequences? Int J Colorectal Dis; 2010 Oct;25(10):1231-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In comparison, 17 specimens of ultralow rectal adenocarcinoma and 4 specimens of anal carcinoma were investigated.
  • We showed that anorectal epithelial differentiation including the squamous epithelia ran in a craniocaudal direction, and that the anorectal zone was a transitional zone between rectal zone and anal transitional zone where CK 7, 18, 20 and CDX2 are simultaneously expressed.
  • All cases of rectal adenocarcinoma showed positivity for CK 18, 20 and CDX2, and three also labelled for CK 7, whereas CK 14 was only expressed in the cases of anal carcinoma.
  • [MeSH-major] Anal Canal / growth & development. Epithelial Cells / cytology. Epithelium / pathology. Rectum / growth & development

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  • (PMID = 20563874.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CDX2 protein, human; 0 / Homeodomain Proteins
  • [Other-IDs] NLM/ PMC2928443
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23. Lee SE, Jeon EJ, Oh JH, Shim KH, Lee J, Kim EH, Choi SW, Min KO: [A case of advanced gastric cancer with perianal skin metastasis]. Korean J Gastroenterol; 2008 Jan;51(1):40-4
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  • He had one painless nodule on perianal skin area, biopsy of that lesion showed a feature of poorly differentiated adenocarcinoma clinically from the stomach.
  • [MeSH-major] Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Aged. Anal Canal. Humans. Male. Neoplasm Staging

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  • (PMID = 18349561.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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24. Chamlou R, Parc Y, Simon T, Bennis M, Dehni N, Parc R, Tiret E: Long-term results of intersphincteric resection for low rectal cancer. Ann Surg; 2007 Dec;246(6):916-21; discussion 921-2
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  • RESULTS: Ninety patients (59 males, 31 females) with a tumor at a median distance of 35 mm (range, 22-52) from the anal verge had an ISR.
  • [MeSH-major] Adenocarcinoma / epidemiology. Anal Canal / surgery. Colectomy / methods. Rectal Neoplasms / epidemiology

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  • (PMID = 18043092.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Kirschner-Hermanns R, Borchers H, Reineke T, Willis S, Jakse G: Fecal incontinence after radical perineal prostatectomy: a prospective study. Urology; 2005 Feb;65(2):337-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / complications. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Aged. Anal Canal / innervation. Anal Canal / physiopathology. Humans. Incidence. Male. Middle Aged. Perineum / surgery. Prospective Studies. Prostatic Neoplasms / complications. Prostatic Neoplasms / radiotherapy. Prostatic Neoplasms / surgery. Radiotherapy, Adjuvant. Surveys and Questionnaires

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  • (PMID = 15708049.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Minicozzi A, Borzellino G, Momo R, Steccanella F, Pitoni F, de Manzoni G: Perianal Paget's disease: presentation of six cases and literature review. Int J Colorectal Dis; 2010 Jan;25(1):1-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The last case was associated to a low rectal adenocarcinoma.
  • We performed a transanal resection of the rectal adenocarcinoma.
  • Anorectal adenocarcinoma was already existing in two cases, synchronous in 48, and subsequent to diagnosis in 11.
  • The review of the literature allows a clear identification of the primitive EMPD and the form associated to anorectal adenocarcinoma and little information about cases associated with synchronous adnexal adenocarcinoma.
  • CONCLUSIONS: Up to now, no clear guidelines have been established for the diagnosis of EMPD.
  • [MeSH-major] Anal Canal / pathology. Paget Disease, Extramammary / pathology

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  • (PMID = 19707774.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 67
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27. Andres AH, Walk CB, Meywirth E, Milkereit E: [Awareness under remifentanil-propofol anaesthesia]. Anaesthesist; 2005 Oct;54(10):1000-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenocarcinoma / surgery. Anal Canal / surgery. Female. Hemodynamics / physiology. Humans. Middle Aged. Pain, Postoperative / psychology. Reconstructive Surgical Procedures. Rectal Neoplasms / surgery

  • Hazardous Substances Data Bank. PROPOFOL .
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  • (PMID = 15999266.001).
  • [ISSN] 0003-2417
  • [Journal-full-title] Der Anaesthesist
  • [ISO-abbreviation] Anaesthesist
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; 0 / Piperidines; P10582JYYK / remifentanil; YI7VU623SF / Propofol
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28. Mavroidis P, al-Abany M, Helgason AR, Agren Cronqvist AK, Wersäll P, Lind H, Qvanta E, Theodorou K, Kappas C, Lind BK, Steineck G, Brahme A: Dose-response relations for anal sphincter regarding fecal leakage and blood or phlegm in stools after radiotherapy for prostate cancer. Radiobiological study of 65 consecutive patients. Strahlenther Onkol; 2005 May;181(5):293-306
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  • [Title] Dose-response relations for anal sphincter regarding fecal leakage and blood or phlegm in stools after radiotherapy for prostate cancer. Radiobiological study of 65 consecutive patients.
  • BACKGROUND: The estimation of the parameters that describe the dose-response relations of anal sphincter regarding the clinical endpoints of fecal leakage and blood or phlegm in stools is important in the optimization of prostate cancer radiotherapy.
  • PATIENTS AND METHODS: In this study, 65 patients who received radiation therapy for clinically localized prostate adenocarcinoma are analyzed.
  • The clinical treatment outcome and the three-dimensional dose distribution delivered to anal sphincter were available for each patient.
  • The clinical utilization of the calculated parameters in predicting anal sphincter complication probabilities was illustrated by applying the best estimate of the parameters to a subset of the patient population.
  • Diminishing the biologically effective uniform dose to anal sphincter < 40-45 Gy may significantly reduce the risk of fecal leakage or blood or phlegm in stools for patients irradiated for prostate cancer.
  • [MeSH-major] Anal Canal / radiation effects. Fecal Incontinence / radionuclide imaging. Prostatic Neoplasms / radiotherapy. Radiotherapy / adverse effects


29. Tsang WW, Chung CC, Kwok SY, Li MK: Laparoscopic sphincter-preserving total mesorectal excision with colonic J-pouch reconstruction: five-year results. Ann Surg; 2006 Mar;243(3):353-8
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  • The mean anastomotic distance from the anal verge was 3.9 cm.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Colonic Pouches. Laparoscopy. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery

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  • (PMID = 16495700.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1448945
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30. Akasu T, Takawa M, Yamamoto S, Fujita S, Moriya Y: Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma. J Am Coll Surg; 2007 Nov;205(5):642-7
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  • [Title] Incidence and patterns of recurrence after intersphincteric resection for very low rectal adenocarcinoma.
  • BACKGROUND: The aim of this study was to evaluate the incidence and patterns of recurrence, or oncologic safety, after intersphincteric resection (ISR) without radiotherapy for very low rectal adenocarcinoma.
  • STUDY DESIGN: One hundred eight consecutive patients with T1-T3 rectal cancers located 1 to 5 cm (median 3 cm) from the anal verge underwent ISR.
  • [MeSH-major] Adenocarcinoma / epidemiology. Neoplasm Recurrence, Local / epidemiology. Rectal Neoplasms / epidemiology
  • [MeSH-minor] Adult. Aged. Anal Canal / surgery. Colectomy. Female. Humans. Incidence. Male. Middle Aged. Retrospective Studies. Survival Analysis

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  • (PMID = 17964439.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Selvindos PB, Ho YH: Multimedia article. Laparoscopic ultralow anterior resection with colonic J-pouch-anal anastomosis. Dis Colon Rectum; 2008 Nov;51(11):1710-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimedia article. Laparoscopic ultralow anterior resection with colonic J-pouch-anal anastomosis.
  • PURPOSE: Optimal treatment of mid to distal rectal cancers includes total mesorectal excision for oncologic clearance and, where reanastomosis is feasible, a colonic J-pouch-anal anastomosis improves bowel function.
  • Patients with adenocarcinoma underwent preoperative endorectal ultrasound to individualize for neoadjuvant chemoradiotherapy, based on local extent and lymph nodes seen.
  • Bowel continuity was restored by an intracoporeal double-cross stapled colonic J-pouch-anal anastomosis, but where not possible a coloplasty with pull-through handsewn coloanal anastomosis was performed.
  • The indications were adenocarcinoma (n = 51), squamous-cell carcinoma of rectum (n = 1), dermoid tumor of mesorectum (n = 1), large villous adenoma (n = 1), and carcinoid with local lymph node metastases (n = 1).
  • The adenocarcinomas were a median distance of 6 (3-12) cm from the anal verge.
  • The histologic grading or the adenocarcinoma patients were: Stage I, n = 14; Stage II, n = 23; Stage III, n = 11; Stage IV, n = 3.
  • The level of the coloanal anastomosis was a median 3.5 (0-4.5) cm from the anal verge; a coloanal pull-through anastomosis was required in one patient who had a distal cancer.
  • At a median follow-up of 14 (2-33) months, none of the adenocarcinoma patients who had undergone curative resection had recurrences.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Colonic Pouches. Laparoscopy / methods. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery

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  • (PMID = 18679748.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Interactive Tutorial
  • [Publication-country] United States
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32. Takada M, Ichihara T, Kuroda Y: Identification of hiatal ligament for laparoscopic total mesorectal excision. Hepatogastroenterology; 2005 Nov-Dec;52(66):1722-4
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  • Resection of the hiatal ligament enables us to isolate the recto-anal canal up to the level of the internal anal sphincter.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Laparoscopy / methods. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery

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  • (PMID = 16334764.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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33. Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong WD, Klimstra DS: Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity? Am J Surg Pathol; 2008 May;32(5):719-31
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  • Guided primarily by the World Health Organization/International Association for the Study of Lung Cancer criteria for pulmonary neuroendocrine tumors, we were able to classify 87 high-grade GI tract tumors that initially carried a diagnosis of either poorly differentiated carcinoma with or without any neuroendocrine characteristics, small cell carcinoma, or combined adenocarcinoma-neuroendocrine carcinoma into the following 4 categories.
  • The fourth was poorly differentiated adenocarcinoma (n=17).
  • Further analysis showed that most HGNECs arising in the squamous lined parts (esophagus and anal canal) were small cell type (78%), whereas most involving the glandular mucosa were large cell (53%) or mixed (82%) type; associated adenocarcinomas were more frequent in large cell (61%) or mixed (36%) type than in small cell type (26%); and focal intracytoplasmic mucin was seen only in large cell or mixed type.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Small Cell / diagnosis. Gastrointestinal Neoplasms / diagnosis. Gastrointestinal Tract / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary. New York / epidemiology. Survival Rate

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  • (PMID = 18360283.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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34. Lu B, Fu CG, Liu LJ, Meng RG, Yu ED, Jin GX, Xing JJ, Yu DH: [Bowel control of elderly low rectal cancer patients after anus-retained operation]. Ai Zheng; 2005 Oct;24(10):1257-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Anal Canal / physiopathology. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / physiopathology. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / physiopathology. Adenocarcinoma, Mucinous / surgery. Age Factors. Aged. Aged, 80 and over. Anastomosis, Surgical. Defecation / physiology. Digestive System Surgical Procedures / methods. Fecal Incontinence / etiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Rectum / surgery

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  • (PMID = 16219144.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. Lou SX, Wang LX, Shi HQ: [Extramammary Paget's disease due to underlying anal canal adenocarcinoma]. Zhonghua Bing Li Xue Za Zhi; 2006 Nov;35(11):701
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extramammary Paget's disease due to underlying anal canal adenocarcinoma].
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Anal Canal / chemistry. Anal Canal / pathology. Anal Canal / surgery. Carcinoembryonic Antigen / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Keratin-20 / analysis. Male. Middle Aged. Mucin-1 / analysis

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  • (PMID = 17374224.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Keratin-20; 0 / Mucin-1
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36. Jeong WK, Park JW, Choi HS, Chang HJ, Jeong SY: Transanal endoscopic microsurgery for rectal tumors: experience at Korea's National Cancer Center. Surg Endosc; 2009 Nov;23(11):2575-9
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  • RESULTS: The median tumor distance from the anal verge was 7 cm (range, 3-15 cm), and the median tumor size was 17 mm (range, 2-60 mm).
  • [MeSH-major] Anal Canal / surgery. Microsurgery / methods. Neoplasm Recurrence, Local / pathology. Proctoscopy / methods. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenoma / mortality. Adenoma / pathology. Adenoma / surgery. Adult. Aged. Cancer Care Facilities. Carcinoid Tumor / mortality. Carcinoid Tumor / pathology. Carcinoid Tumor / surgery. Cohort Studies. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Korea. Male. Middle Aged. Minimally Invasive Surgical Procedures / adverse effects. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Patient Selection. Postoperative Complications / diagnosis. Postoperative Complications / surgery. Reoperation. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 19347399.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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37. Prete F, Prete FP, Nitti P, De Luca R, Vincenti L: [Evolution of surgery for cancer of the anorectal junction]. Chir Ital; 2007 Nov-Dec;59(6):763-70
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  • Certain aspects of the epidemiology, classification and therapy of adenocarcinoma of the anorectal junction (< 5 cm from the anal verge) are not well standardised to date.
  • Assessment of anal sphincter function recovery one year after restoration of bowel continuity showed good continence in 76% of the patients; 2 patients have a permanent ostomy.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18360980.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Italy
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38. Akasu T, Takawa M, Yamamoto S, Ishiguro S, Yamaguchi T, Fujita S, Moriya Y, Nakanishi Y: Intersphincteric resection for very low rectal adenocarcinoma: univariate and multivariate analyses of risk factors for recurrence. Ann Surg Oncol; 2008 Oct;15(10):2668-76
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  • [Title] Intersphincteric resection for very low rectal adenocarcinoma: univariate and multivariate analyses of risk factors for recurrence.
  • BACKGROUND: The aim of this study was to analyze the risk factors for local and distant recurrence after intersphincteric resection (ISR) for very low rectal adenocarcinoma.
  • METHODS: One hundred twenty consecutive patients with T1-T3 rectal cancers located 1-5 (median 3) cm from the anal verge underwent ISR.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Neoplasm Recurrence, Local / diagnosis. Rectal Neoplasms / surgery

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  • (PMID = 18618181.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-19-9 Antigen
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39. Yang R, Cheung MC, Zhuge Y, Armstrong C, Koniaris LG, Sola JE: Primary solid tumors of the colon and rectum in the pediatric patient: a review of 270 cases. J Surg Res; 2010 Jun 15;161(2):209-16
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  • Tumors were identified in the right colon (45.9%), transverse colon (9.3%), left colon (20.4%), rectum (15.2%), and anal canal (1.1%).
  • The most common histology of these tumors was adenocarcinoma (35.6%), followed by carcinoid (34.1%).

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19285688.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Tanaka K, Noura S, Ohue M, Seki Y, Gotou K, Motoori M, Kishi K, Takachi K, Eguchi H, Yamada T, Miyashiro I, Ohigashi H, Yano M, Ishikawa O, Imaoka S, Murata K, Kameyama M: [A case of refractory inguinal lymphorrhea cured by lipiodol lymphangiography]. Gan To Kagaku Ryoho; 2007 Nov;34(12):2162-4
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  • The patient was a 80-year-old female who underwent an abdomino-perineal resection with lateral pelvic lymph node dissection and inguinal lymph node extraction for anal canal cancer.
  • Histologically, the tumor was a poorly differentiated adenocarcinoma and considered to be stage IV (a2, n3 (+), P0, H3, M (-), cur C) in the Japanese classification of colorectal cancer.
  • [MeSH-major] Iodized Oil. Lymphatic Diseases / diagnosis

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  • (PMID = 18219932.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 8001-40-9 / Iodized Oil
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41. Christoforidis D, Cho HM, Dixon MR, Mellgren AF, Madoff RD, Finne CO: Transanal endoscopic microsurgery versus conventional transanal excision for patients with early rectal cancer. Ann Surg; 2009 May;249(5):776-82
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  • METHODS: We retrospectively reviewed information on all patients with stage pT1 and pT2 rectal adenocarcinoma who underwent local excision from 1997 through mid-2006.
  • In the TAE group, 52 (40%) of tumors were <5 cm from the anal verge (AV); in the TEMS group, only 1 (2%) (P = 0.0001).
  • In our multivariate analysis, the tumor distance from the anal verge, the resection margin status, the T stage, and the use of adjuvant therapy--but not the surgical technique (i.e., TEMS or TAE) itself--were independent predictors of local recurrence and DFS.
  • [MeSH-major] Adenocarcinoma / surgery. Endoscopy, Digestive System. Neoplasm Recurrence, Local. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Female. Humans. Male. Microsurgery. Middle Aged. Patient Selection. Prognosis. Retrospective Studies. Survival Analysis


42. Lee J, Corman M: Recurrence of anal adenocarcinoma after local excision and adjuvant chemoradiation therapy: report of a case and review of the literature. J Gastrointest Surg; 2009 Jan;13(1):150-4
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  • [Title] Recurrence of anal adenocarcinoma after local excision and adjuvant chemoradiation therapy: report of a case and review of the literature.
  • INTRODUCTION: Tumors arising from the anal canal are rare, comprising 1.5% of all gastrointestinal tumors in the USA.
  • The vast majority of these anal cancers are epidermoid (cloacogenic/basaloid and squamous cell carcinomas), while adenocarcinomas reportedly occur 5% to 19% of the time.
  • Because of its rarity, reports about anal adenocarcinoma are limited to small retrospective studies and case reports.
  • CASE PRESENTATION: We describe a case of recurrent anal adenocarcinoma after conservative management with local excision and adjuvant chemoradiation therapy.
  • [MeSH-major] Adenocarcinoma / surgery. Antineoplastic Agents / therapeutic use. Anus Neoplasms / pathology. Anus Neoplasms / therapy. Colectomy / methods

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  • (PMID = 18810561.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Zhou JN, Wang DZ, Huang XE, Xu FP, Shang JQ, Gu RM: Transabdominal transanal resection of distal rectal cancer after high dose preoperative radiotherapy: a Chinese experience in preserving sphincter function. Isr Med Assoc J; 2006 Oct;8(10):675-8
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  • BACKGROUND: The combination of high dose preoperative radiotherapy and transanal abdominal transanal radical proctosigmoidectomy and colo-anal anastomosis as a sphincter-preserving method has never been performed in mainland China.
  • METHODS: From September 1994 to September 2000, 25 consecutive patients with pathologically confirmed distal rectal adenocarcinoma were treated preoperatively with a total dose of 45-46 Gy at 1.8-2.0 Gy per fraction during 5 weeks.
  • [MeSH-major] Abdomen / surgery. Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Anal Canal / physiopathology. Anal Canal / surgery. Rectal Neoplasms / radiotherapy. Rectal Neoplasms / surgery

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  • [CommentIn] Isr Med Assoc J. 2006 Oct;8(10):711-2 [17125121.001]
  • (PMID = 17125111.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Israel
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44. Kobayashi H, Ueno H, Hashiguchi Y, Ishiguro M, Omata J, Kajiwara Y, Shimazaki H, Mochizuki H: T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma. Jpn J Clin Oncol; 2006 May;36(5):325-8
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  • [Title] T1 neuroendocrine carcinoma of anal canal after transanal resection for intramucosal adenocarcinoma.
  • Neuroendocrine carcinomas of the anal canal are rare, representing 1% of malignant tumors of the anal canal.
  • We describe the case of a 63-year-old female with T1 neuroendocrine carcinoma of the anal canal arising from the site of a previous transanal excision performed 13 months earlier for intramucosal adenocarcinoma of the anal canal.
  • In this case, it is likely that the neuroendocrine tumor, which infiltrated into the submucosal layer with venous invasion, had developed over the intervening 13 months following the original transanal excision of the adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Anus Neoplasms / etiology. Carcinoma, Neuroendocrine / etiology. Neoplasm Recurrence, Local

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  • (PMID = 16702164.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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45. Colvin M, Delis A, Bracamonte E, Villar H, Leon LR Jr: Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal. World J Gastroenterol; 2009 Jul 28;15(28):3560-4
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  • [Title] Infiltrating adenocarcinoma arising in a villous adenoma of the anal canal.
  • Primary neoplasms arising in the anal canal are relatively unusual.
  • We describe an infiltrating, well-differentiated adenocarcinoma arising in a villous adenoma from the distal anal canal, in an otherwise healthy patient at low risk for gastrointestinal malignancy.
  • Microscopic evaluation revealed an infiltrating well-differentiated adenocarcinoma, arising from a villous adenoma.
  • This was further evaluated under anesthesia and complete excision of distal anal tissue was performed.
  • Our report is the first describing the possible malignant degeneration of a villous adenoma in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Villous / pathology. Anal Canal / pathology

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  • (PMID = 19630115.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
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46. Tomimaru Y, Ohue M, Noura S, Tanida T, Miyashiro I, Yano M, Ohigashi H, Sasaki Y, Ishikawa O, Imaoka S: [A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer]. Gan To Kagaku Ryoho; 2005 Oct;32(11):1776-8
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  • [Title] [A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer].
  • A 63-year-old man with a history of anal fistula was admitted to our hospital because the anal pain didn't disappear after the operation.
  • On digital examination, a hard mass measuring 3.0 cm in diameter was found at the anal canal.
  • Biopsy of the mass showed moderately differentiated adenocarcinoma.
  • Colonoscopy revealed another rectal cancer at 15 cm from anal verge.
  • Biopsy of the tumor also showed moderately differentiated adenocarcinoma, resembling the anal canal tumor.
  • Because the histological findings of both tumors were nearly identical, we considered that cancer cells from the rectal cancer had been implanted and developed the metastatic tumor in the anal fistula.
  • The patient underwent anterior resection for the rectal cancer, and a local resection for the anal canal cancer.
  • We may suggest from these results that cancer cells from the rectal cancer had been implanted and developed the metastatic tumor in the anal canal.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Anus Neoplasms / secondary. Rectal Fistula / complications. Rectal Neoplasms / pathology


47. Dyson T, Draganov PV: Squamous cell cancer of the rectum. World J Gastroenterol; 2009 Sep 21;15(35):4380-6
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  • Diagnosis relies on endoscopic examination with biopsy of the lesion.
  • Compared to adenocarcinoma of the rectum and squamous cell cancer of the anal canal, squamous cell carcinoma of the rectum has different epidemiology, etiology, pathogenesis, and prognosis but, most importantly, requires a different therapeutic approach.

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  • (PMID = 19764088.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic
  • [Number-of-references] 76
  • [Other-IDs] NLM/ PMC2747057
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48. Qiu HZ, Lin GL, Zhou JL, Xiao Y, Wu B: [Transanal endoscopic microsurgery for the treatment of localized rectal neoplasms]. Zhonghua Wai Ke Za Zhi; 2009 Jul 1;47(13):981-3
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  • The average distance of lesions from the anal verge was (7.6 +/- 2.8) cm (range, 5-20 cm).
  • The postoperative pathological examination identified 28 cases of rectal adenoma, 25 rectal adenocarcinoma or carcinomatous changes of adenoma (14 cases with phase Tis tumor, 5 cases T1 and 6 cases T2), 7 rectal carcinoid and 15 cases of inflammatory polyps or others.
  • Postoperative complications occurred in 4 cases (5.3%), included 2 cases of anal hemorrhage, 1 case of pulmonary infection and 1 urinary infection.
  • [MeSH-minor] Adult. Aged. Anal Canal / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures. Retrospective Studies. Treatment Outcome

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  • (PMID = 19957806.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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49. Li LR, Wan DS, Pan ZZ, Zhou ZW, Chen G, Wu XJ, Lu ZH, Ding PR: [Clinical features and treatment of 49 patients with anal canal adenocarcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 Sep;9(5):402-4
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  • [Title] [Clinical features and treatment of 49 patients with anal canal adenocarcinoma].
  • OBJECTIVE: To investigate the clinical features and treatment of anal canal adenocarcinoma.
  • METHODS: Clinical data of 49 patients with anal canal adenocarcinoma treated in our hospital from January 1965 to March 2002 were analyzed retrospectively.
  • Anal bleeding, tapering stool and anal lump were the most common symptoms.
  • CONCLUSIONS: Anal canal adenocarcinoma is a rare and fatal malignancy.
  • [MeSH-major] Adenocarcinoma / therapy. Anus Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 17043960.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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50. Mohammad A, Makaju R: Retrospective histopathological analysis of various neoplasms of different parts of the gastrointestinal tract seen at the Kathmandu University Teaching Hospital (KUTH), Dhulikhel, Nepal. Kathmandu Univ Med J (KUMJ); 2006 Oct-Dec;4(4):474-8
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  • OBJECTIVE: To find out the spectrum of various histopathologic types of primary neoplasms of different parts of the gastrointestinal tract (oesophagus, stomach, small intestine, colorectum, anal canal) seen at the Kathmandu University Teaching Hospital (KUTH), Dhulikhel as there exists a worldwide wide variation in the distribution of various neoplasms of different parts of the gastrointestinal tract, which appears largely due to exogenous factors rather than due to inherent differences between populations.
  • Out of these, 3 (16.7%) were of the oesophagus (all squamous cell carcinoma), 10 (55.5%) were of the stomach (six intestinal type and four diffuse type), 2 (11.1%) were of the small intestine (one was lymphoma of the mucosa associated lymphoid tissue--MALTOMA and other was a malignant gastrointestinal stromal tumour--GIST), 3 (16.7%) were of the colorectum (all adenocarcinoma), and none was of the anal canal.

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  • (PMID = 18603957.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nepal
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51. Lohsiriwat V, Lohsiriwat D, Boonnuch W, Chinswangwatanakul V, Akaraviputh T, Riansuwan W, Lert-akyamanee N: Outcomes of sphincter-saving operation for rectal cancer without protective stoma and pelvic drain, and risk factors for anastomotic leakage. Dig Surg; 2008;25(3):191-7
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  • Median tumor height was 8 cm (range 3-15) from the anal verge.
  • Tumor height within 5 cm from the anal verge was the only independent factor for leakage (OR 4.04; 95% CI 1.25-13.08).
  • Tumor height within 5 cm from the anal verge is an independent risk factor for anastomotic leakage.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal. Rectal Neoplasms / surgery

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18577863.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
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52. Rink AD, Vestweber B, Vestweber KH: Modified ileocecal interposition. The final sphincter-saving solution after failed salvage surgery for anastomotic complications of low anterior resection. Dig Surg; 2008;25(5):359-63
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  • The fistulas were cured and a hand-sutured colo-anal anastomosis was performed at the level of the dentate line.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal. Cecum / transplantation. Ileum / transplantation. Proctocolectomy, Restorative / methods. Rectal Fistula / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18957851.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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53. Pocard M, Sideris L, Zenasni F, Duvillard P, Boige V, Goéré D, Elias D, Malka D, Ducreux M, Lasser P: Functional results and quality of life for patients with very low rectal cancer undergoing coloanal anastomosis or perineal colostomy with colonic muscular graft. Eur J Surg Oncol; 2007 May;33(4):459-62
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  • METHODS: Between 1991 and 2001, 50 patients were operated for a very low rectal adenocarcinoma and analyzed after a follow-up greater than one year and because there was no relapse or no treatment, they were included in the analysis.
  • [MeSH-major] Anal Canal / surgery. Anastomosis, Surgical / methods. Colon / surgery. Colostomy / methods. Muscle, Smooth / transplantation. Quality of Life. Recovery of Function. Rectal Neoplasms / physiopathology. Rectal Neoplasms / surgery. Salvage Therapy / methods

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  • (PMID = 17123774.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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54. Danova NA, Robles-Emanuelli JC, Bjorling DE: Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs. Vet Surg; 2006 Jun;35(4):337-40
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  • [Title] Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs.
  • OBJECTIVE: To describe an anal approach for excision of primary rectal tumors in dogs and to report outcome.
  • METHODS: Review of medical records (1990-2000) of dogs with primary rectal neoplasia excised surgically using an anal approach with rectal prolapse.
  • With dogs anesthetized, the rectum was prolapsed, stabilized with stay sutures during tumor excision with 1 cm margins to the level of the muscularis, then the rectal mucosa was sutured.
  • RESULTS: Each dog had only 1 tumor type (adenocarcinoma [8], solitary polyp [5], carcinoma [4], plasmacytoma [2], adenoma [1], leiomyoma [1], mucinous carcinoma [1], and papilloma [1]).
  • CLINICAL RELEVANCE: An anal approach facilitated by rectal prolapse should be considered as a viable option for the surgical treatment of selected cases of tumors of the caudal aspect of the rectum in dogs.
  • [MeSH-major] Anal Canal / surgery. Dog Diseases / surgery. Rectal Neoplasms / veterinary
  • [MeSH-minor] Adenocarcinoma / surgery. Adenocarcinoma / veterinary. Animals. Disease-Free Survival. Dogs. Female. Male. Polyps / surgery. Polyps / veterinary. Postoperative Complications / veterinary. Records as Topic / veterinary. Retrospective Studies. Treatment Outcome. Wisconsin / epidemiology

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  • (PMID = 16756613.001).
  • [ISSN] 0161-3499
  • [Journal-full-title] Veterinary surgery : VS
  • [ISO-abbreviation] Vet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Zacharakis E, Freilich S, Rekhraj S, Athanasiou T, Paraskeva P, Ziprin P, Darzi A: Transanal endoscopic microsurgery for rectal tumors: the St. Mary's experience. Am J Surg; 2007 Nov;194(5):694-8
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  • The histologic diagnosis was adenoma in 48 and adenocarcinoma in 28 patients.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma / surgery. Colonoscopy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / surgery. Female. Humans. Male. Microsurgery. Middle Aged

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  • (PMID = 17936438.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Li SY, Liang ZJ, Yuan SJ, Yu B, Chen G, Zuo FY, Bai X, Chen G, Wei XJ, Xu YS, Cui W: [Clinical experience of 371 cases of sphincter-preservation with telescopic anastomosis after radical excision for low-middle rectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi; 2010 Apr;13(4):263-5
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  • OBJECTIVE: To evaluate the clinical efficacy, feasibility and safety of sphincter-preservation with telescopic anastomosis of colon and rectal mucosa in low-middle rectal cancer.
  • The lower margins of the tumors located between 5-8 cm from the anal verge.
  • On histopathology, there were 361 adenocarcinomas, including 138 well-differentiated, 201 moderately differentiated, 11 poorly differentiated, 11 mucinous adenocarcinoma, and 10 adenomas with neoplastic changes.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Anastomosis, Surgical / methods. Rectal Neoplasms / surgery

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  • (PMID = 20422480.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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57. Jeyarajah S, Sutton C, Miller A, Hemingway D, Leicester Colorectal Specialist Group: Colo-anal pouches: lessons from a prospective audit. Colorectal Dis; 2008 Jul;10(6):599-604
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  • [Title] Colo-anal pouches: lessons from a prospective audit.
  • OBJECTIVE: Colonic pouch formation with pouch-anal anastomosis is the treatment of choice following restorative anterior resection for low rectal cancers with a proximal loop ileostomy to defunction the anastomosis.
  • RESULTS: Forty-two patients with rectal adenocarcinoma underwent an anterior resection with colo-colonic pouch, colo-anal anastomosis and a covering loop ileostomy.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Anastomosis, Surgical. Colonic Pouches. Rectal Neoplasms / surgery

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  • (PMID = 18215195.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media
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58. Damin DC, Tolfo GC, Rosito MA, Spiro BL, Kliemann LM: Sentinel lymph node in patients with rectal cancer invading the anal canal. Tech Coloproctol; 2010 Jun;14(2):133-9
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  • [Title] Sentinel lymph node in patients with rectal cancer invading the anal canal.
  • BACKGROUND: To assess the feasibility of the sentinel lymph node procedure in patients with rectal cancer extending to the anal canal.
  • METHODS: Between January 2005 and April 2008, 15 patients with adenocarcinoma of the rectum with direct invasion of the anal canal and no clinical evidence of inguinal involvement were prospectively enrolled in the study.
  • Four patients (26.7%) had sentinel nodes identified as positive for metastatic adenocarcinoma.
  • Although this technique can be potentially useful for a subgroup of patients with isolated inguinal metastases, it cannot be routinely recommended for patients with rectal tumors invading the anal canal at this moment.
  • [MeSH-major] Adenocarcinoma / secondary. Anal Canal. Inguinal Canal. Rectal Neoplasms / pathology. Sentinel Lymph Node Biopsy

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  • [Cites] Eur J Surg Oncol. 2008 Aug;34(8):890-4 [18178364.001]
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  • (PMID = 20424879.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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59. Morello E, Martano M, Squassino C, Iussich S, Caccamo R, Sammartano F, Zabarino S, Bellino C, Pisani G, Buracco P: Transanal pull-through rectal amputation for treatment of colorectal carcinoma in 11 dogs. Vet Surg; 2008 Jul;37(5):420-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To evaluate outcome after transanal rectal pull-through amputation of single colorectal adenocarcinoma and in situ carcinoma (Tis) in dogs.
  • RESULTS: Adenocarcinoma (8) and Tis (2) were removed with 3-6 cm of grossly normal tissue, cranial and caudal to the tumor, or in 1 Tis with 2 cm grossly normal tissue, cranial and caudal.
  • Postoperative recurrence and metastatic rates for adenocarcinoma were 18.2% and 0%, respectively.
  • CONCLUSION: En bloc excision of colorectal Tis and adenocarcinoma may be followed by a long survival.
  • [MeSH-major] Adenocarcinoma / veterinary. Anal Canal / surgery. Colorectal Neoplasms / veterinary. Dog Diseases / surgery

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  • (PMID = 18986308.001).
  • [ISSN] 1532-950X
  • [Journal-full-title] Veterinary surgery : VS
  • [ISO-abbreviation] Vet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Lisovsky M, Patel K, Cymes K, Chase D, Bhuiya T, Morgenstern N: Immunophenotypic characterization of anal gland carcinoma: loss of p63 and cytokeratin 5/6. Arch Pathol Lab Med; 2007 Aug;131(8):1304-11
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  • [Title] Immunophenotypic characterization of anal gland carcinoma: loss of p63 and cytokeratin 5/6.
  • Anal gland carcinoma (AGC) is a rare perianal invasive cancer composed of tubular glands lined by cuboidal epithelium.
  • The clinical features and histogenesis of AGC are not well understood and its origin from anal glands is often difficult to prove.
  • Little is known about immunophenotypic features of AGC that could be useful in establishing the diagnosis.
  • This study evaluated the immunohistochemical profile of 2 cases of AGC in comparison to anal glands from 11 hemorrhoidectomy specimens.
  • In biopsies from this case, the neoplastic anal glands had a tubular pattern, whereas most glands in the resection specimen exhibited mucinous features.
  • Normal anal glands showed immunoreactivity for myoepithelial and basal cell markers CK5/6 and p63 in basal and parabasal cell layers and for CK7 in superficial cell layers.
  • Anal gland carcinoma shares negativity for CDX2 and CK7+/CK20- profile with normal anal glands.
  • No evidence of myoepithelial cells was found in normal or malignant anal glands.
  • These data may be useful in establishing the diagnosis of AGC.
  • [MeSH-major] Adenocarcinoma / pathology. Anus Neoplasms / pathology. Biomarkers, Tumor / metabolism. Keratin-5 / metabolism. Keratin-6 / metabolism. Membrane Proteins / metabolism
  • [MeSH-minor] Anal Canal / metabolism. Anal Canal / pathology. Fluorescent Antibody Technique, Indirect. Hemorrhoids / pathology. Hemorrhoids / surgery. Humans. Immunoenzyme Techniques. Immunophenotyping. Male. Middle Aged

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  • [CommentIn] Arch Pathol Lab Med. 2008 Oct;132(10):1547-8 [18834205.001]
  • (PMID = 17683193.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Keratin-5; 0 / Keratin-6; 0 / Membrane Proteins
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61. Smeenk RJ, van Lin EN, van Kollenburg P, Kunze-Busch M, Kaanders JH: Anal wall sparing effect of an endorectal balloon in 3D conformal and intensity-modulated prostate radiotherapy. Radiother Oncol; 2009 Oct;93(1):131-6
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  • [Title] Anal wall sparing effect of an endorectal balloon in 3D conformal and intensity-modulated prostate radiotherapy.
  • BACKGROUND AND PURPOSE: To investigate the anal wall (Awall) sparing effect of an endorectal balloon (ERB) in 3D conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for prostate cancer.
  • This may lead to reduced late anal toxicity in prostate radiotherapy.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Anal Canal / radiation effects. Prostatic Neoplasms / radiotherapy. Radiotherapy, Conformal / methods. Radiotherapy, Intensity-Modulated / methods

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  • (PMID = 19523704.001).
  • [ISSN] 1879-0887
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
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62. Shinoda M, Hatano S, Kawakubo H, Kakefuda T, Omori T, Ishii S: Adult cecoanal intussusception caused by cecum cancer: report of a case. Surg Today; 2007;37(9):802-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pathological finding was submucosal adenocarcinoma in adenoma.
  • [MeSH-major] Anal Canal / pathology. Cecal Neoplasms / complications. Cecum / pathology. Intussusception / etiology

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  • [Cites] Dis Colon Rectum. 1988 Aug;31(8):629-31 [3402288.001]
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  • (PMID = 17713738.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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63. Gurzu S, Jung J, Azamfirei L, Mezei T, Cîmpean AM: The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas. Rom J Morphol Embryol; 2007;48(4):349-53
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  • [Title] The aspects of angiogenesis in anal canal carcinomas compared with that in colorectal carcinomas.
  • AIM: To compare the angiogenesis in anal canal carcinomas (ACC) with that in colorectal carcinomas (CRC).
  • [MeSH-minor] Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Humans. Immunohistochemistry. Neoplasm Staging

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  • (PMID = 18060184.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Romania
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64. Fiducia G, Gandolfo L, Bosco V: [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases]. Chir Ital; 2008 Mar-Apr;60(2):227-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases].
  • Local transanal excision as primary treatment of rectal and anal canal adenomas in selected patients is supported by the recent literature.
  • Sixteen patients with low rectal or anal canal neoplastic polyps underwent transanal resection.
  • Histologically, 2 were tubular adenomas without atypia (12.5%), 3 were tubulo-villous adenomas with moderate atypia (18.75%), 8 were tubulo-villous adenomas (50%) with severe atypia, 2 were tubulo-villous adenomas with locally invasive foci of adenocarcinoma (12.5%), and 1 case was a pT1 cloacogenic carcinoma (6.25%).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Digestive System Surgical Procedures / methods. Humans. Middle Aged

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  • (PMID = 18689170.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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65. Tachezy R, Jirasek T, Salakova M, Ludvikova V, Kubecova M, Horak L, Mandys V, Hamsikova E: Human papillomavirus infection and tumours of the anal canal: correlation of histology, PCR detection in paraffin sections and serology. APMIS; 2007 Mar;115(3):195-203
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus infection and tumours of the anal canal: correlation of histology, PCR detection in paraffin sections and serology.
  • Different histological variants of anal carcinomas displaying squamous differentiation, previously classified as separate tumours, were recently reclassified as SCCA by the WHO.
  • In our recent study the presence of HPV was detected by PCR in biopsy specimens of 42 different anal tumours, including SCCA and its histological variants (n=22), adenocarcinomas (n=5), tubulovillous adenomas (n=5) and anal condylomas (n=10).
  • HPV16 was identified in one adenocarcinoma, while four cases were HPV negative.
  • Seven anal condylomas (70%) were LR HPV 6 and/or 11 positive, while three were HPV negative.
  • The presence of HR HPV types was not observed in anal condylomas.

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  • (PMID = 17367464.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 9004-22-2 / Globins
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66. Chambers WM, McC Mortensen NJ: Should ileal pouch-anal anastomosis include mucosectomy? Colorectal Dis; 2007 Jun;9(5):384-92
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  • [Title] Should ileal pouch-anal anastomosis include mucosectomy?
  • Whilst mucosectomy results in a more complete removal of diseased mucosa, this benefit may be at the price of poorer function.
  • Potential reasons for functional problems were investigated, as were rates of 'cuffitis', dysplasia, polyposis and cancer in the ileal pouch and anal canal.
  • The most likely reason for functional impairment following pouch surgery was the degree of anal manipulation.
  • CONCLUSION: Stapled anastomosis avoiding mucosectomy is the approach of choice for ileal pouch anal anastomosis because this leads to superior functional outcome.
  • Performing mucosectomy results in some clinical benefits in terms of lower rates of inflammation and dysplasia in the retained mucosa in UC patients and lower rates of cuff polyposis in FAP patients.
  • [MeSH-major] Colonic Pouches / adverse effects. Intestinal Mucosa / surgery. Proctocolectomy, Restorative / adverse effects
  • [MeSH-minor] Adenocarcinoma / prevention & control. Adenomatous Polyposis Coli / surgery. Anastomosis, Surgical / adverse effects. Anastomosis, Surgical / methods. Anus Neoplasms / prevention & control. Arsenates. Colitis, Ulcerative / surgery. Humans. Ileal Neoplasms / prevention & control. Randomized Controlled Trials as Topic

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  • (PMID = 17504334.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arsenates; N7CIZ75ZPN / arsenic acid
  • [Number-of-references] 70
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67. Irabor DO, Dongo AE: Anal carcinoma in a tropical low socio-economic population in the new millennium: What has changed? Trop Doct; 2009 Jan;39(1):7-9
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  • [Title] Anal carcinoma in a tropical low socio-economic population in the new millennium: What has changed?
  • The paper is a retrospective look at the clinicopathological presentation of carcinoma of the anal canal in a tertiary health institution in Nigeria.
  • Sixty-five patients were diagnosed with anal carcinoma over a five-year period (2002-2006) from a total of 394 patients who had malignancies of the colon, rectum and anus.
  • The male: female ratio was 1.2: 1 showing a slight male predominance; the average age was 48 years; tenesmus, bleeding per rectum and anal pain were the most common presenting features.
  • The most predominant histopathological subtype was adenocarcinoma - a departure from the hitherto squamous cell cancer dominance.
  • [MeSH-major] Adenocarcinoma. Anus Neoplasms. Carcinoma
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Anal Canal / surgery. Female. Humans. Male. Middle Aged. Nigeria / epidemiology. Socioeconomic Factors. Tropical Climate. Young Adult

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  • (PMID = 19211411.001).
  • [ISSN] 0049-4755
  • [Journal-full-title] Tropical doctor
  • [ISO-abbreviation] Trop Doct
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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68. Portier G, Ghouti L, Kirzin S, Guimbaud R, Rives M, Lazorthes F: Oncological outcome of ultra-low coloanal anastomosis with and without intersphincteric resection for low rectal adenocarcinoma. Br J Surg; 2007 Mar;94(3):341-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oncological outcome of ultra-low coloanal anastomosis with and without intersphincteric resection for low rectal adenocarcinoma.
  • Cox multivariable analysis revealed that resection of the anal canal was not a prognostic factor for local or metastatic recurrence.
  • [MeSH-major] Adenocarcinoma / surgery. Colonic Pouches. Proctocolectomy, Restorative / methods. Rectal Neoplasms / surgery

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  • [Copyright] (c) 2007 British Journal of Surgery Society Ltd.
  • [CommentIn] Br J Surg. 2007 Jul;94(7):912; author reply 913 [17571287.001]
  • (PMID = 17262755.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] England
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69. Kawahara H, Watanabe K, Ushigome T, Noaki R, Kobayashi S, Yanaga K: Retrograde single stapling technique for laparoscopic ultralow anterior resection. Dig Surg; 2010;27(4):261-4
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  • After the anal side of the tumor has been closed transanally, the distal line in the right lateral wall of the rectum is partially transected with laparoscopic coagulation shears (LCS).
  • After an anvil is placed in the proximal end of the colon over a purse-string suture, it is introduced to the anal canal transabdominally.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Anal Canal / surgery. Anastomosis, Surgical / methods. Anastomotic Leak. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Proctoscopy / methods. Risk Assessment. Sampling Studies. Treatment Outcome

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20668381.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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70. Chang GJ, Gonzalez RJ, Skibber JM, Eng C, Das P, Rodriguez-Bigas MA: A twenty-year experience with adenocarcinoma of the anal canal. Dis Colon Rectum; 2009 Aug;52(8):1375-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A twenty-year experience with adenocarcinoma of the anal canal.
  • PURPOSE: Adenocarcinoma of the anal canal is a rare malignancy with limited data regarding treatment and outcomes.
  • The purpose of this study is to evaluate disease control and survival outcomes in patients with adenocarcinoma of the anal canal.
  • METHODS: A retrospective consecutive cohort study of all patients in whom adenocarcinoma of the anal canal was diagnosed between 1983 and 2004 was performed.
  • CONCLUSION: Combined modality treatment with radical surgical resection improves survival among patients with adenocarcinoma of the anal canal, but a high risk for distant failure emphasizes the need for effective adjuvant therapeutic regimens.
  • [MeSH-major] Adenocarcinoma / epidemiology. Anus Neoplasms / epidemiology

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  • (PMID = 19617747.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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71. Donigan M, Loh BD, Norcross LS, Li S, Williamson PR, DeJesus S, Ferrara A, Gallagher JT, Baker CH: A metastatic colon cancer model using nonoperative transanal rectal injection. Surg Endosc; 2010 Mar;24(3):642-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: For this study, 60 Balb/c mice were anesthetized and subjected to gentle anal dilation using blunt-tipped forceps at the anal opening.
  • Two mice (3.3%) from the 2.5 x 10(4) CT26-luc group showed metastatic colonic adenocarcinoma to the liver on postinjection day 50.
  • [MeSH-minor] Anal Canal. Animals. Cell Line, Tumor. Disease Models, Animal. Injections / methods. Mice. Mice, Inbred BALB C

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  • [Cites] N Engl J Med. 2004 May 13;350(20):2050-9 [15141043.001]
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  • (PMID = 19688392.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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72. Corner C, Bryant L, Chapman C, Glynne-Jones R, Hoskin PJ: High-dose-rate afterloading intraluminal brachytherapy for advanced inoperable rectal carcinoma. Brachytherapy; 2010 Jan-Mar;9(1):66-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Between 1993 and 2007, 79 patients were treated with HDR afterloading brachytherapy for rectal cancer; 70 patients had adenocarcinoma of the rectum; and 9 patients had squamous cell carcinoma of the anal canal.
  • [MeSH-major] Adenocarcinoma / radiotherapy. Brachytherapy / methods. Carcinoma, Squamous Cell / radiotherapy. Rectal Neoplasms / radiotherapy

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  • [Copyright] Copyright (c) 2010 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.
  • (PMID = 19846349.001).
  • [ISSN] 1873-1449
  • [Journal-full-title] Brachytherapy
  • [ISO-abbreviation] Brachytherapy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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73. al-Abany M, Helgason AR, Cronqvist AK, Lind B, Mavroidis P, Wersäll P, Lind H, Qvanta E, Steineck G: Toward a definition of a threshold for harmless doses to the anal-sphincter region and the rectum. Int J Radiat Oncol Biol Phys; 2005 Mar 15;61(4):1035-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Toward a definition of a threshold for harmless doses to the anal-sphincter region and the rectum.
  • PURPOSE: To investigate dysfunction caused by unwanted radiation to the anal-sphincter region and the rectum.
  • METHODS AND MATERIALS: A questionnaire assessing bowel symptoms, sexual function, and urinary symptoms was sent to 72 patients with clinically localized prostatic adenocarcinoma treated by external beam radiation therapy at the Radiumhemmet, Karolinska Hospital, in Stockholm, Sweden, 2-4 years after treatment.
  • None of the 19 and 13 patients who received, respectively, a dose of > or =35 Gy to < or =60% or > or =40 Gy to < or =40% of the anal-sphincter region volume reported fecal leakage (p < 0.05).
  • In dose-volume histograms, a statistically significant correlation was found between radiation to the anal-sphincter region and the risk of fecal leakage in the interval 45-55 Gy.
  • CONCLUSIONS: Although the limited data in this study prevent the definition of a conclusive threshold regarding volume and dose to the anal-sphincter region and untoward morbidity, it seems that careful monitoring of unnecessary irradiation to this area should be done because it can potentially help reduce the risk of adverse effects, such as fecal leakage.
  • Future studies should pay more attention to the anal-sphincter region and help to more rigorously define its radiotherapeutic tolerance.
  • [MeSH-minor] Aged. Aged, 80 and over. Anal Canal / radiation effects. Diarrhea / etiology. Health Surveys. Humans. Male. Middle Aged. Radiotherapy Dosage. Threshold Limit Values

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  • (PMID = 15752882.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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74. Leung KK, Yusuf TE: External polypectomy of a large anal canal polyp. Gastrointest Endosc; 2007 Sep;66(3):603; discussion 604
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] External polypectomy of a large anal canal polyp.
  • [MeSH-major] Adenocarcinoma / surgery. Adenoma, Villous / surgery. Anus Neoplasms / surgery. Intestinal Polyps / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic / pathology. Electrosurgery. Female. Humans. Intestinal Mucosa / pathology. Proctoscopy. Sutures

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  • (PMID = 17681501.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Zuo ZG, Song HY, Li J, Xu C, Zhou ZH, Ni SC, Chen SQ: [Clinical application of intersphincteric resection in the anal-preserving operation for ultra-low rectal carcinoma]. Zhonghua Zhong Liu Za Zhi; 2009 Dec;31(12):941-4
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  • [Title] [Clinical application of intersphincteric resection in the anal-preserving operation for ultra-low rectal carcinoma].
  • OBJECTIVE: To investigate the clinical application of intersphincter resection (ISR) combined with total mesorectal excision (TME) and colon-anal anastomosis in the treatment for ultra-low rectal carcinoma.
  • METHODS: To review and analyze retrospectively the data of 34 patients with ultra-low rectal carcinoma (without external anal sphincter involvement) who received treatment of ISR, TME and colon-anal anastomosis.
  • Reconstruction of digestive tract was done by manual colon-anal anastomosis.
  • The pathological types were as follows: 28 cases of adenocarcinoma (11 were well differentiated, 17 moderately differentiated), 1 case of papillary carcinoma and 5 cases of villous adenoma with malignant change.
  • CONCLUSION: With strictly grasping indications, radical resection can be attained and anal sphincter preserved by ISR combined with TME and colon-anal anastomosis.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / surgery. Rectum / surgery

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  • (PMID = 20193339.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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76. Alvarez G, Perry A, Tan BR, Wang HL: Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification. Mod Pathol; 2006 Jul;19(7):942-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of epidermal growth factor receptor in squamous cell carcinomas of the anal canal is independent of gene amplification.
  • Immunohistochemical detection of expression of the epidermal growth factor receptor (EGFR) has been utilized to identify eligible patients with solid malignant tumors, including colorectal adenocarcinoma, for monoclonal antibody therapy (eg, cetuximab).
  • The EGFR status in squamous cell carcinoma of the anal canal, an uncommon malignancy traditionally treated with chemoradiation, has not been well investigated.
  • In this study, 38 primary squamous cell carcinomas of the anal canal were immunohistochemically examined for EGFR expression and analyzed by fluorescence in situ hybridization (FISH) for EGFR gene copy numbers.
  • These results demonstrate that EGFR is overexpressed in more than one-half of the squamous cell carcinomas of the anal canal through mechanisms other than gene amplification.

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  • (PMID = 16648870.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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77. Melis M, Gruel R, Darwin P, Drachenberg C, Shibata D: Full thickness transanal re-excision following endoscopic removal of malignant rectal polyps. Int J Colorectal Dis; 2009 May;24(5):531-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Six patients were found to have residual disease (three adenoma, two adenocarcinoma, one positive lymph node).
  • [MeSH-major] Anal Canal / surgery. Endoscopy. Rectal Neoplasms / surgery

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  • (PMID = 19159936.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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78. Val-Bernal JF, Mayorga M, Diego C, González-Vela MC: Pedunculated polypoid lymphangioma of the anal canal. Pathol Int; 2008 Jul;58(7):442-4
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  • [Title] Pedunculated polypoid lymphangioma of the anal canal.
  • To the authors' knowledge a lymphangioma of the anal canal has not been reported.
  • Described herein is a case of pedunculated polypoid lymphangioma of the right lateral wall on the transitional zone of the anal canal measuring 1.7 x 1.3 x 1 cm in a 40-year-old woman.
  • A pedicle does not exclude the endoscopic diagnosis of lymphangioma.
  • Lymphangioma must be included in the differential diagnosis of polypoid lesions of the anal canal.
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Rectal Fistula / pathology

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  • (PMID = 18577114.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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79. Pescatori M, Spyrou M, Bilali S, Spinelli F, Orsini S: Low anterior intersphincteric resection, total mesorectal excision, coloplasty and coloanal anastomosis with neoanal smooth muscle encirclement for low rectal cancer. Tech Coloproctol; 2005 Jul;9(2):185
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Colon / surgery. Muscle, Smooth / transplantation. Rectal Neoplasms / surgery. Rectum / surgery

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  • (PMID = 16292622.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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80. Chetty R, Serra S, Hsieh E: Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant. Am J Surg Pathol; 2005 Dec;29(12):1668-72
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  • [Title] Basaloid squamous carcinoma of the anal canal with an adenoid cystic pattern: histologic and immunohistochemical reappraisal of an unusual variant.
  • Two cases of a distinctive variety of basaloid squamous carcinoma (BSC) of the anal canal are described.
  • Accompanying dysplasia of the overlying squamous mucosa was absent.
  • BSC of the anal canal with an adenoid cystic pattern is an infrequently encountered and reported variant, although it is seen more often in the aerodigestive tract.
  • The histologic differential diagnosis is true salivary gland-type adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Immunohistochemistry and awareness of this unusual pattern of BSC will facilitate the correct diagnosis being reached.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Basosquamous / pathology

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  • (PMID = 16327441.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antigens, CD20; 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; 50SG953SK6 / Mitomycin; 68238-35-7 / Keratins; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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81. Ho YH: Techniques for restoring bowel continuity and function after rectal cancer surgery. World J Gastroenterol; 2006 Oct 21;12(39):6252-60
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  • A very low local recurrence rate of 3%-6% (associated with improved 5 year survival) is possible when proper oncological surgery is performed of mid and distal rectal adenocarcinoma.
  • Colonic J-pouch-anal anastomosis patients have a median of 3 bowel movements a day compared with a median of 6 a day for straight anastomoses, at 1 year after surgery.
  • In the longer term, bowel adaptation may enable the function after a straight anastomosis to approximate that of a colonic J-pouch-anal anastomosis.
  • An additional advantage of the colonic J-pouch-anal anastomosis is the lower risk of anastomotic complications.
  • A more vascularized side-to-end (colonic J-pouch-anal) anastomosis is likely to heal better than an end-to-end (straight) anastomosis.
  • Where the pelvis is too narrow for a bulky colonic J-pouch anal anastomosis, a coloplasty-anal-anastomosis is an option.
  • [MeSH-major] Adenocarcinoma / surgery. Gastrointestinal Motility / physiology. Postoperative Care / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / surgery. Anastomosis, Surgical / adverse effects. Anastomosis, Surgical / methods. Colon / pathology. Colon / surgery. Colonic Pouches / pathology. Defecation. Humans. Laparoscopy / methods. Rectum / surgery

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  • (PMID = 17072945.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Editorial; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Number-of-references] 60
  • [Other-IDs] NLM/ PMC4088130
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82. Kim NK, Kim YW, Min BS, Lee KY, Sohn SK, Cho CH: Operative safety and oncologic outcomes of anal sphincter-preserving surgery with mesorectal excision for rectal cancer: 931 consecutive patients treated at a single institution. Ann Surg Oncol; 2009 Apr;16(4):900-9
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  • [Title] Operative safety and oncologic outcomes of anal sphincter-preserving surgery with mesorectal excision for rectal cancer: 931 consecutive patients treated at a single institution.
  • [MeSH-major] Adenocarcinoma / surgery. Colectomy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Anal Canal. Chemotherapy, Adjuvant. Female. Humans. Male. Middle Aged. Neoadjuvant Therapy. Radiotherapy, Adjuvant. Treatment Outcome

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  • (PMID = 19198951.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Martino P, Martino D, Palazzo S, Altomare DF, Garofalo L, Battaglia M, Selvaggi FP: Incidental discovery of ano-rectal disease during transrectal ultrasound performed for prostatic disease. Arch Ital Urol Androl; 2005 Mar;77(1):37-9
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  • In 132 cases (27%) it was shown to be a false positive, mainly due to imperfect cleansing of the anal canal; in 284 cases (58%) benign disease was demonstrated (hemorrhoids in 192 patients, abscesses in 21, perianal fistulas in 18, inflamed lymph nodes in 27, polyps in 16).
  • In 34 patients (7%) a malignant tumor was found (infiltration of the anterior rectal wall by a prostatic adenocarcinoma in 13, and a primitive adenocarcinoma of rectal origin in the remaining 21).
  • It can be concluded that transrectal US does not permit a certain diagnosis of the nature of rectal disease, but does raise a diagnostic suspicion that can orient the surgeon to schedule more invasive diagnostic investigations.

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  • (PMID = 15906788.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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84. Sacchi M, Legge PD, Picozzi P, Papa F, Giovanni CL, Greco L: Virtual ileostomy following TME and primary sphincter-saving reconstruction for rectal cancer. Hepatogastroenterology; 2007 Sep;54(78):1676-8
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  • Because the most specific complication following rectal resection with anastomosis is symptomatic leakage, which is associated with 18% mortality rate, routine formation of a temporary stoma is suitable after sphincter-saving resection for anastomoses situated at or less than 5cm from the anal verge.
  • [MeSH-major] Anal Canal / surgery. Ileostomy / instrumentation. Ileostomy / methods. Rectal Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Anastomosis, Surgical / methods. Carcinoma. Female. Humans. Male. Middle Aged. Risk. Sex Factors. Time Factors. Treatment Outcome

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  • (PMID = 18019692.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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85. Kuroda N, Tanida N, Ohara M, Hirouchi T, Mizuno K, Kubo A, Lee GH: Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin. Med Mol Morphol; 2007 Mar;40(1):50-3
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  • [Title] Anal canal adenocarcinoma with MUC5AC expression suggestive of anal gland origin.
  • Anal canal adenocarcinomas arising in the anal ducts or glands are very rare neoplasms, and few useful immunohistochemical markers of these carcinomas are known to date.
  • A 57-year-old man presented with anal bleeding, difficulty of defecation, and anal pain.
  • Macroscopic findings of the surgically resected material showed circular stenosis of the anal canal.
  • Microscopically, the proliferation of adenocarcinoma cells with mucin production was observed in the submucosal and muscular layers.
  • Immunohistochemically, normal rectal-type mucosa and normal anal ducts/glands showed the patterns of cytokeratin 7 (CK7)(-)/CK19(+, focal)/MUC5AC(-) and CK7(+, diffuse)/CK19(+, diffuse)/MUC5AC(+, focal), respectively, and neoplastic cells showed the pattern of CK7(+, diffuse)/CK19(+, diffuse)/MUC5AC(+, focal).
  • Finally, our preliminary report suggests that the immunohistochemical combination of CK7, CK19, and MUC5AC may be an available marker for adenocarcinoma of anal ducts/glands origin.
  • [MeSH-major] Adenocarcinoma / pathology. Anal Canal / pathology. Anus Neoplasms / pathology. Mucins / metabolism

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  • (PMID = 17384991.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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86. Kounalakis N, Artinyan A, Smith D, Mojica-Manoso P, Paz B, Lai LL: Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal. Ann Surg Oncol; 2009 May;16(5):1310-5
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  • [Title] Abdominal perineal resection improves survival for nonmetastatic adenocarcinoma of the anal canal.
  • BACKGROUND: There remains a lack of consensus regarding the optimal treatment for patients with curable adenocarcinoma of the anal canal (AAC).
  • [MeSH-major] Adenocarcinoma / surgery. Anus Neoplasms / surgery. Colectomy / methods

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  • (PMID = 19241106.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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87. Wallace MH, Glynne-Jones R: Saving the sphincter in rectal cancer: are we prepared to change practice? Colorectal Dis; 2007 May;9(4):302-8; discussion 308-9
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  • This article examines the effect such treatment has on the rate of sphincter preservation in patients with rectal cancers close to the anal sphincter mechanism and looks at the evidence for changing clinical practice.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / physiopathology. Anal Canal / surgery. Digestive System Surgical Procedures / methods. Rectal Neoplasms / surgery

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  • (PMID = 17432980.001).
  • [ISSN] 1462-8910
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 51
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88. Donigan M, Norcross LS, Aversa J, Colon J, Smith J, Madero-Visbal R, Li S, McCollum N, Ferrara A, Gallagher JT, Baker CH: Novel murine model for colon cancer: non-operative trans-anal rectal injection. J Surg Res; 2009 Jun 15;154(2):299-303
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  • [Title] Novel murine model for colon cancer: non-operative trans-anal rectal injection.
  • RESULTS: In the initial study, 3/7 mice injected using 10x magnifications had notable, large tumor originating from the rectal wall, and histology revealed that all excised tumors were poorly differentiated adenocarcinoma.
  • The overall success of tumor take was 65% using the trans-anal rectal injection model.
  • [MeSH-major] Adenocarcinoma / secondary. Colonic Neoplasms / pathology. Disease Models, Animal. Mice, Inbred BALB C. Neoplasm Transplantation / methods. Rectum / pathology
  • [MeSH-minor] Anal Canal. Animals. Cell Differentiation. Cell Line, Tumor. Injections / methods. Lung / pathology. Lung Neoplasms / secondary. Mice. Rectal Neoplasms / pathology

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  • (PMID = 19101690.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Hamada M, Ozaki K, Iwata J, Nishioka Y, Horimi T: A case of rectosigmoid cancer metastasizing to a fistula in ano. Jpn J Clin Oncol; 2005 Nov;35(11):676-9
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  • A 53-year-old man complaining of anal bleeding consulted another hospital.
  • He had been suffering from an anal fistula since 7 years.
  • The post-operative pathological diagnosis was rectosigmoid cancer, Type 2, T2, N0, M0, stage II.
  • The anal fistula was a simple type and mucinous discharge was not observed.
  • On 23 February 2004, coring out the anal fistula was performed by the former hospital.
  • Pathological diagnosis of the excised fistula revealed well-differentiated adenocarcinoma; identical to the colon tumor.
  • We diagnosed this tumor as metastatic adenocarcinoma from a rectosigmoid cancer.
  • [MeSH-major] Adenocarcinoma / secondary. Anus Neoplasms / secondary. Rectal Fistula / pathology. Rectal Neoplasms / pathology. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Anal Canal / pathology. Humans. Lymph Node Excision. Male. Middle Aged

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  • (PMID = 16275674.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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90. Krengli M, Milia ME, Turri L, Mones E, Bassi MC, Cannillo B, Deantonio L, Sacchetti G, Brambilla M, Inglese E: FDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma. Radiat Oncol; 2010;5:10
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  • [Title] FDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma.
  • BACKGROUND: FDG-PET/CT imaging has an emerging role in staging and treatment planning of various tumor locations and a number of literature studies show that also the carcinoma of the anal canal may benefit from this diagnostic approach.
  • We analyzed the potential impact of FDG-PET/CT in stage definition and target volume delineation of patients affected by carcinoma of the anal canal and candidates for curative radiotherapy.
  • METHODS: Twenty seven patients with biopsy proven anal carcinoma were enrolled.
  • Pathology was squamous cell carcinoma in 20 cases, cloacogenic carcinoma in 3, adenocarcinoma in 2, and basal cell carcinoma in 2.
  • CONCLUSIONS: FDG-PET/CT has a potential relevant impact in staging and target volume delineation of the carcinoma of the anal canal.

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  • [Cites] Radiother Oncol. 2001 Oct;61(1):15-22 [11578724.001]
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  • (PMID = 20137093.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2851594
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91. Balachandra B, Marcus V, Jass JR: Poorly differentiated tumours of the anal canal: a diagnostic strategy for the surgical pathologist. Histopathology; 2007 Jan;50(1):163-74
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  • [Title] Poorly differentiated tumours of the anal canal: a diagnostic strategy for the surgical pathologist.
  • Poorly differentiated malignancies affecting the anal canal are uncommon but pose diagnostic difficulties because of the wide range of normal cell types that may occur within a limited anatomical region.
  • The range of lesions that may present as poorly differentiated tumours includes squamous cell carcinoma, adenocarcinoma, small and large cell neuroendocrine carcinoma, neuroendocrine carcinoma expressing epithelial cytokeratins and other patterns of mixed differentiation, undifferentiated carcinoma, malignant melanoma, lymphoma and secondary tumours.
  • This review discusses the differential diagnosis of these neoplasms with the aid of short illustrative case studies.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Lymphoma / pathology. Male. Melanoma / pathology. Middle Aged. Pathology, Surgical / methods

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  • (PMID = 17204029.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 72
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92. Ito M, Saito N, Sugito M, Kobayashi A, Nishizawa Y, Tsunoda Y: Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer. Dis Colon Rectum; 2009 Jan;52(1):64-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer.
  • PURPOSE: The purpose of this study was to identify factors that have a negative impact on anal function after intersphincteric resection.
  • METHODS: We evaluated postoperative anal function in 96 patients with very lower rectal cancer who underwent intersphincteric resection by having patients fill out detailed questionnaires at 3, 6, 12, and 24 months after surgery.
  • Univariate and multivariate analysis based on the Wexner incontinence score were used to identify factors associated with poor anal function after intersphincteric resection.
  • Patients with frequent major soiling showed a Wexner score of >or=16, and this score was used as a cutoff value of poor anal function.
  • In the univariate analysis, poor anal function was significantly associated with a greater extent of excision of the internal sphincter and with preoperative chemoradiotherapy.
  • In the multivariate analysis, preoperative chemoradiotherapy was the only independent factor associated with poor anal function after intersphincteric resection (odds ratio=10.3; 95 percent confidence interval, 2.3-46.3, P < 0.01).
  • CONCLUSIONS: Preoperative chemoradiotherapy was identified as the risk factor with the greatest negative impact on anal function after intersphincteric resection, regardless of extent of excision of the internal sphincter.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / physiopathology. Anal Canal / surgery. Fecal Incontinence / etiology. Rectal Neoplasms / surgery

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  • [CommentIn] Dis Colon Rectum. 2010 Jun;53(6):958-9 [20485014.001]
  • (PMID = 19273958.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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93. Sakakura C, Nishio M, Miyagawa K, Miyashita A, Nagata H, Kin S, Fukuda K, Nakase Y, Hagiwara A, Nakanishi M, Yamazaki J, Yoshikawa S, Okamoto K, Kokuba Y, Otsuji E: Laparoscope-assisted superlow anterior resection combined with inter sphincteric rectal dissection for very low advanced rectal cancers combined with preoperative chemotherapy. Hepatogastroenterology; 2009 May-Jun;56(91-92):692-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This patient showed favorable recovery including postoperative anal function with no complications or recurrent disease.
  • This procedure is feasible and has favorable short-term results for the radical treatment of very low rectal disease, while preserving anal function.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Antineoplastic Agents / therapeutic use. Dissection / methods. Laparoscopy. Rectal Neoplasms / surgery

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  • (PMID = 19621682.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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94. Ulaş M, Neşşar G, Bostanoğlu A, Aydoğ G, Kayaalp C, Ozoğul Y, Seven C: Development of two cancers in the same patient after ileorectal and ileal pouch anal anastomosis for familial adenomatous polyposis. Med Princ Pract; 2006;15(1):83-6
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  • [Title] Development of two cancers in the same patient after ileorectal and ileal pouch anal anastomosis for familial adenomatous polyposis.
  • After 19 years, in situ adenocarcinoma was detected in the rectal stump.
  • Completion proctectomy, mucosectomy, and hand-sewn ileal pouch anal anastomosis with protective ileostomy were performed.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenomatous Polyposis Coli / surgery. Anal Canal / surgery. Carcinoma, Squamous Cell / diagnosis. Colonic Neoplasms / complications. Ileostomy

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  • (PMID = 16340235.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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95. Tsai BM, Finne CO, Nordenstam JF, Christoforidis D, Madoff RD, Mellgren A: Transanal endoscopic microsurgery resection of rectal tumors: outcomes and recommendations. Dis Colon Rectum; 2010 Jan;53(1):16-23
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  • Local recurrence rates for 121 benign and 83 malignant tumors were 5% for adenomas, 9.8% for T1 adenocarcinoma, 23.5% for T2 adenocarcinoma, 100% for T3 adenocarcinoma, and 0% for carcinoid tumors.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Colectomy / methods. Rectal Neoplasms / pathology. Rectal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal. Female. Humans. Male. Microsurgery. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 20010345.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Mukai M, Fukasawa M, Kishima K, Iizuka S, Fukumitsu H, Yazawa N, Tajima T, Nakamura M, Makuuchi H: Trans-anal reinforcing sutures after double stapling for lower rectal cancer: report of two cases. Oncol Rep; 2009 Feb;21(2):335-9
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  • [Title] Trans-anal reinforcing sutures after double stapling for lower rectal cancer: report of two cases.
  • In June 2008, LACS was performed for a tumor of 6 cm in longer diameter in the Rb region of the lower rectum approximately 5 cm from the anal verge.
  • After intraperitoneal coloproctal anastomosis was performed in the pelvis by the double stapling technique (DST), reinforcement was provided by manual trans-anal suturing (trans-anal reinforcing sutures: TARS).
  • In June 2008, LACS was performed for a tumor of 5 cm in longer diameter in the Ra region of the lower rectum approximately 7 cm from the anal verge.
  • In patients having surgical treatment of advanced lower rectal cancer, good results were obtained by adding circumferential reinforcing sutures via the trans-anal approach at the site of ultra-low anastomosis after DST.
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Digestive System Surgical Procedures / methods. Rectal Neoplasms / surgery. Suture Techniques


97. Rengan R, Paty P, Wong WD, Guillem J, Weiser M, Temple L, Saltz L, Minsky BD: Distal cT2N0 rectal cancer: is there an alternative to abdominoperineal resection? J Clin Oncol; 2005 Aug 1;23(22):4905-12
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  • The purpose of this trial is to determine whether preoperative external-beam radiation therapy can increase the rate of sphincter preservation for patients with distal cT2N0 adenocarcinoma of the rectum.
  • PATIENTS AND METHODS: Between April 1988 and October 2003, 27 patients with distal rectal adenocarcinoma staged T2 by clinical and/or endorectal ultrasound who were judged by the operating surgeon to require an APR were treated with preoperative pelvic radiation alone (50.4 Gy).
  • [MeSH-major] Adenocarcinoma / radiotherapy. Adenocarcinoma / surgery. Anal Canal / surgery. Rectal Neoplasms / radiotherapy. Rectal Neoplasms / surgery

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  • (PMID = 16051945.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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98. Yokoyama Y, Nishimura Y, Yatsuoka T, Sakamoto H, Tanaka Y, Nishimura Y, Kurosumi M: [A case of anal metastasis from sigmoid colon cancer in a long-term survivor who had repeated local excisions]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2585-7
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  • [Title] [A case of anal metastasis from sigmoid colon cancer in a long-term survivor who had repeated local excisions].
  • Histopathological examination revealed a moderately differentiated adenocarcinoma, tub 2, SS, ly2, v2, N1, H0, P0, M0, Stage IIIa, cur A.
  • In March 2001, he complained of an anal bleeding and underwent colonoscopy.
  • It showed a submucosal tumor 15 mm in diameter at the anal canal and the biopsy indicated a moderately differentiated adenocarcinoma.
  • Histopathological examination revealed a moderately differentiated adenocarcinoma, which was the same histological type as primary sigmoid colon cancer, tub 2, A, ly2, v2, RM0.
  • The diagnosis of anal metastasis was made on the basis of three points.
  • First, tumor was covered with anal epithelium.
  • Thirdly, there were no findings of other primary anal cancer.
  • By removing anal canal metastases twice, inguinal lymph node metastases three times and lung metastases in each time, he survived for 11 years after a primary surgery.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Anus Neoplasms / secondary. Anus Neoplasms / surgery. Sigmoid Neoplasms / pathology

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  • (PMID = 21224647.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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99. Zuo ZG, Song HY, Xu C, Li J, Ni SC, Chen SQ: [Combination of trans-anal intersphincteric resection and trans-abdominal total mesorectal excision for anus-retained ultra-low rectal tumors]. Zhonghua Wai Ke Za Zhi; 2009 Jul 1;47(13):988-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Combination of trans-anal intersphincteric resection and trans-abdominal total mesorectal excision for anus-retained ultra-low rectal tumors].
  • OBJECTIVE: To study the combination of trans-anal intersphincteric resection and transabdominal total mesorectal excision for anus-retained ultra-low rectal tumors.
  • METHODS: Clinical data of 34 ultra-low rectal tumor patients without external anal sphincter involved, who underwent the combination surgery, were retrospectively analyzed.
  • For pathological types, there were 23 cases of adenocarcinoma (9 well differentiated and 14 moderately differentiated), 1 papillary carcinoma, 2 rectal stromal tumor, 5 rectal villous adenoma with neoplasia and 3 giant villous adenoma.
  • However, patients underwent total resection of internal anal sphincter still suffered from incontinence of loose stool after 1 year.
  • CONCLUSION: The combination of trans-anal ISR and trans-abdominal TME for anus-retained ultra low rectal tumor is not only coincident with radical tumor principle but also retains the function of anus, on the premise of the strict indication.
  • [MeSH-major] Anal Canal / surgery. Mesentery / surgery. Rectal Neoplasms / surgery

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  • (PMID = 19957808.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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100. Kong AP, Kim J, Holt A, Konyalian V, Huynh R, Udani SM, Stamos MJ, Kumar RR: Selective treatment of rectal cancer with single-stage coloanal or ultralow colorectal anastomosis does not adversely affect morbidity and mortality. Int J Colorectal Dis; 2007 Aug;22(8):897-901
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  • MATERIALS AND METHODS: A retrospective chart review of 66 rectal cancer patients who underwent proctectomy and low pelvic anastomoses -- less than 6 cm from anal verge, with or without a diverting ostomy -- was undertaken.
  • The mean anastomotic height for patients with a single stage procedure was 3.8 cm above the anal verge versus 2.6 for patients with a two-stage procedure (p = 0.076).
  • [MeSH-major] Adenocarcinoma / surgery. Anal Canal / surgery. Colon / surgery. Digestive System Surgical Procedures / methods. Rectal Neoplasms / surgery. Rectum / surgery. Surgical Stomas

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  • (PMID = 17361396.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
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