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1. Grant EA, Trzupek KM, Reiss J, Crow K, Messiaen L, Weleber RG: Combined retinal hamartomas leading to the diagnosis of neurofibromatosis type 2. Ophthalmic Genet; 2008 Sep;29(3):133-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patient one presented to ophthalmology at the age of 2 years; by 4 years, he developed what was thought to be a plexiform neurofibroma and, with more than 6 cafe au lait spots, was diagnosed with neurofibromatosis type 1 (NF1).
  • By the age of 5, he had developed bilateral vestibular schwannomas, and was diagnosed with NF2.
  • Despite lack of pathological evidence of neurofibroma upon biopsy, molecular testing was initiated at age 6 and revealed a truncating mutation in exon 8 (c.734delA) of the NF2 gene in the blood.
  • The recognition of this rare finding as a presenting feature of NF2 can lead to earlier diagnosis, which is vital to appropriate surveillance and possible surgical intervention.

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  • (PMID = 18766994.001).
  • [ISSN] 1744-5094
  • [Journal-full-title] Ophthalmic genetics
  • [ISO-abbreviation] Ophthalmic Genet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Codon, Nonsense
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2. Liscak R, Vladyka V, Urgosik D, Simonova G, Vymazal J: Repeated treatment of vestibular schwannomas after gamma knife radiosurgery. Acta Neurochir (Wien); 2009 Apr;151(4):317-24; discussion 324
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeated treatment of vestibular schwannomas after gamma knife radiosurgery.
  • The results and risks of repeat treatment of patients with a vestibular schwannoma were reviewed to assess its efficacy and safety.
  • METHODS: Between 1992 and 2001, we treated 351 patients with a vestibular schwannoma by GKS, control of the growth of the tumour was not achieved in 32.
  • CONCLUSIONS: In the small proportion of patients (9%) in whom initial GKS does not control the growth of a vestibular schwannoma, most can be controlled by further GKS with a very low risk of a complications.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / adverse effects. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve Injuries / epidemiology. Female. Hearing Loss, Sensorineural / epidemiology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures / statistics & numerical data. Reoperation / adverse effects. Reoperation / statistics & numerical data. Risk Assessment. Vestibular Nerve / pathology. Vestibular Nerve / surgery. Young Adult

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  • (PMID = 19277457.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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3. Bayazit YA, Celenk F, Duzlu M, Goksu N: Management of cerebrospinal fluid leak following retrosigmoid posterior cranial fossa surgery. ORL J Otorhinolaryngol Relat Spec; 2009;71(6):329-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The CSF leaks were documented in 22 of the vestibular schwannoma surgeries (68.7%) and 10 of the vestibular nerve sectioning surgeries (31.3%).
  • No CSF leak was seen following microvascular decompression and auditory brain stem implantation surgeries.
  • [MeSH-major] Cerebrospinal Fluid Rhinorrhea / surgery. Cerebrospinal Fluid Rhinorrhea / therapy. Cranial Fossa, Posterior / surgery. Drainage / methods. Neuroma, Acoustic / surgery

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 20068375.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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4. Kameda K, Shono T, Hashiguchi K, Yoshida F, Sasaki T: Effect of tumor removal on tinnitus in patients with vestibular schwannoma. J Neurosurg; 2010 Jan;112(1):152-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of tumor removal on tinnitus in patients with vestibular schwannoma.
  • OBJECT: Tinnitus is one of the most common symptoms in patients with vestibular schwannomas (VSs), but the effect of surgery on this symptom has not been fully evaluated.
  • The aim of this study was to define the effect on tinnitus of tumor removal, cochlear nerve resection, and useful hearing preservation in patients with VSs.
  • RESULTS: Of 242 patients, 171 (70.7%) complained of tinnitus before surgery; the symptom disappeared in 25.2%, improved in 33.3%, remained unchanged in 31.6%, and worsened in 9.9% of these cases after tumor removal.
  • In the 171 patients with preoperative tinnitus, the cochlear nerve was resected in 85 (49.7%) and preserved in 86 (50.3%), but there was no significant difference in the incidence of postoperative tinnitus between these 2 groups (p = 0.293).
  • Among those without preoperative tinnitus, the cochlear nerve was resected in 45 cases (63.4%) and tinnitus appeared postoperatively in 3 (6.7%).
  • CONCLUSIONS: Tumor removal via the retrosigmoid lateral suboccipital approach may provide some chance for improvement of tinnitus in patients with VSs; however, neither cochlear nerve resection nor useful hearing preservation affects the postoperative development of tinnitus.
  • [MeSH-major] Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Tinnitus / etiology. Tinnitus / surgery
  • [MeSH-minor] Cochlear Nerve / surgery. Female. Hearing Disorders / etiology. Humans. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Treatment Outcome


5. Hasegawa T, Fujitani S, Katsumata S, Kida Y, Yoshimoto M, Koike J: Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years. Neurosurgery; 2005 Aug;57(2):257-65; discussion 257-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years.
  • OBJECTIVE: Many investigators have reported successful treatment of vestibular schwannomas with gamma knife radiosurgery (GKRS).
  • However, long-term outcomes should be evaluated before concluding that GKRS is truly safe and effective for the treatment of vestibular schwannomas.
  • Of 301 patients who underwent serial follow-up imaging, two (1%) experienced complete remission, 184 (61%) experienced partial remission, 93 (31%) had stable tumors, and 22 (7%) experienced treatment failure.
  • Tumors less than 15 cm3 in volume (10-yr PFS, 96%; P < 0.001) or which did not compress the brainstem and deviate the fourth ventricle (10-yr PFS, 97%; P = 0.008) resulted in significantly better PFS rates.
  • When the tumor was treated with a marginal dose of 13 Gy or less, the hearing preservation rate was 68%, transient facial palsy developed at a rate of 1%, and facial numbness developed at a rate of 2%.
  • CONCLUSION: GKRS proved to be a safe and effective treatment for patients followed longer than 5 years who presented with tumors with a volume of less than 15 cm3 and who did not have significant fourth ventricle deviation.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 16094154.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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6. Tlachacova D, Schmitt M, Novotny J Jr, Novotny J, Majali M, Liscak R: A comparison of the gamma knife model C and the Automatic Positioning System with Leksell model B. J Neurosurg; 2005 Jan;102(s_supplement):25-28
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data were analyzed in patients in whom the following diagnoses had been made: vestibular schwannoma, pituitary adenoma, meningioma, solitary metastasis, and other benign and malignant solitary tumors.
  • CONCLUSIONS: With the C model there was a better conformity for most treated targets, such as vestibular schwannomas (p = 0.005) and meningiomas (p = 0.015).

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  • (PMID = 28306471.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; conformity index / extracranial exposure / staff exposure / stereotactic radiosurgery
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7. Parhizkar N, Hiltzik DH, Selesnick SH: Facial nerve rerouting in skull base surgery. Otolaryngol Clin North Am; 2005 Aug;38(4):685-710, ix
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial nerve rerouting in skull base surgery.
  • Facial nerve rerouting techniques were developed to facilitate re-section of extensive tumors occupying the skull base.
  • Facial nerve rerouting has its own limitations and risks, requiring microsurgical expertise, additional surgical time, and often some degree of facial nerve paresis.
  • This article presents different degrees of anterior and posterior facial nerve rerouting, techniques of facial nerve rerouting, and a comprehensive review of outcomes.
  • It then reviews anatomic and functional preservation of the facial nerve in acoustic neuroma resection, technical aspects of facial nerve dissection, intracranial facial nerve repair options, and outcomes for successful acoustic neuroma surgery.
  • [MeSH-major] Facial Nerve / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Cranial Fossa, Middle / surgery. Dissection. Glomus Jugulare Tumor / surgery. Glomus Tumor / surgery. Humans. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 16005726.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 79
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8. Wang CP, Hsu WC, Young YH: Vestibular evoked myogenic potentials in neurofibromatosis 2. Ann Otol Rhinol Laryngol; 2005 Jan;114(1 Pt 1):69-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular evoked myogenic potentials in neurofibromatosis 2.
  • Neurofibromatosis 2 (NF2) is characterized by bilateral vestibular neurofibromas.
  • Although the facial nerve, the cochlear nerve, and the superior division of the vestibular nerve can be evaluated before surgery, whether the inferior division of the vestibular nerve is affected remains undetermined without an operation.
  • A total of 7 patients with NF2 (2 men and 5 women) underwent pure tone audiometry, caloric testing, vestibular evoked myogenic potential (VEMP) testing, and magnetic resonance imaging.
  • Magnetic resonance imaging depicted space-occupying lesions in all 14 auditory canals: small tumors in 3 ears, medium tumors in 7 ears, and large tumors in 4 ears.
  • The tumor size of NF2 is related to the caloric response, but is unrelated to the mean hearing level or VEMPs.
  • In conclusion, NF2 originates from the superior vestibular nerve more often than the inferior vestibular nerve.
  • It more often infiltrates the cochlear nerve than the inferior vestibular nerve.
  • [MeSH-major] Evoked Potentials, Auditory / physiology. Neurofibromatosis 2 / physiopathology. Neuroma, Acoustic / physiopathology. Vestibular Function Tests
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry, Pure-Tone. Caloric Tests. Facial Paralysis / etiology. Female. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Nystagmus, Pathologic. Radiosurgery. Tinnitus / etiology

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  • (PMID = 15697166.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Kliesch S, Vogelgesang S, Benecke R, Horstmann GA, Schroeder HW: Malignant brain oedema after radiosurgery of a medium-sized vestibular schwannoma. Cent Eur Neurosurg; 2010 May;71(2):88-91
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  • [Title] Malignant brain oedema after radiosurgery of a medium-sized vestibular schwannoma.
  • CASE REPORT: We present a patient with an unusual malignant brain oedema occurring after gamma knife radiosurgery of a medium-sized vestibular schwannoma.
  • CLINICAL PRESENTATION: A 62-year-old female with a large vestibular schwannoma underwent partial microsurgical resection; 6 months later she underwent a second intervention with gamma knife radiosurgery for a medium-sized tumour remnant.
  • Surprisingly, the brain oedema resolved rapidly.
  • CONCLUSION: Although rare, radiosurgery of medium-sized vestibular schwannomas causing brainstem compression may lead to life-threatening tumour progression and malignant brain oedema.
  • Therefore, microsurgical gross total resection should be the preferred treatment option in vestibular schwannomas causing significant brainstem compression.
  • [MeSH-major] Brain Edema / etiology. Brain Edema / pathology. Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects. Radiosurgery / instrumentation
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Staging. Recovery of Function

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  • [Copyright] Copyright Georg Thieme Verlag KG Stuttgart . New York.
  • (PMID = 20063260.001).
  • [ISSN] 1868-4912
  • [Journal-full-title] Central European neurosurgery
  • [ISO-abbreviation] Cent Eur Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. Kutz JW, Barnett SL, Hatanpaa KJ, Mendelsohn DB: Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor. Skull Base; 2009 Nov;19(6):443-6
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  • [Title] Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor.
  • Vestibular schwannomas account for ~;80% of cerebellopontine angle (CPA) tumors, with meningiomas being the second most common tumor of the CPA.
  • The occurrence of both a schwannoma and a meningioma in the cerebellopontine angle is rare.
  • After obtaining Institutional Review Board approval, we present a case of a concurrent vestibular schwannoma and meningioma in the CPA mimicking a single tumor.

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  • [Cites] Neurosurgery. 1992 Mar;30(3):443-5; discussion 445-6 [1620314.001]
  • [Cites] Clin Neuropathol. 2007 Sep-Oct;26(5):219-23 [17907598.001]
  • [Cites] J Neuropathol Exp Neurol. 1993 Mar;52(2):106-13 [8440992.001]
  • [Cites] Otolaryngol Head Neck Surg. 1993 Jul;109(1):88-95 [8336973.001]
  • (PMID = 20436847.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793893
  • [Keywords] NOTNLM ; Acoustic neuroma / cerebellopontine angle / meningioma / vestibular schwannoma
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11. Solares CA, Panizza B: Vestibular schwannoma: an understanding of growth should influence management decisions. Otol Neurotol; 2008 Sep;29(6):829-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma: an understanding of growth should influence management decisions.
  • BACKGROUND: Treatments for vestibular schwannomas include surgical removal and radiotherapy.
  • Observation is a reasonable alternative, given the slow growth of these tumors.
  • METHODS: Patients with unilateral vestibular schwannomas who presented in the last 10 years were reviewed.
  • The following information was recorded from the charts: age, sex, tumor size at presentation and subsequent follow-up sessions, treatment in the event of growth, and time interval between presentation and last imaging available.
  • Interestingly, 11 patients (10%) demonstrated tumor regression.
  • Patients with intracanalicular tumors had a 5-year no-growth rate of 89.8% compared with 73.9% and 45.2% for Grade I and Grade II or larger tumors, respectively.
  • The difference between intracanalicular and Grade II or larger tumors was statistically significant (p = 0.0196).
  • CONCLUSION: Our data suggest that treatment can be delayed in a large proportion of vestibular schwannoma patients and that this is particularly true in patients with small tumors.
  • [MeSH-major] Ear Neoplasms / radiotherapy. Ear Neoplasms / surgery. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery

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  • (PMID = 18636034.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Evans DG, Ramsden RT, Gokhale C, Bowers N, Huson SM, Wallace A: Should NF2 mutation screening be undertaken in patients with an apparently isolated vestibular schwannoma? Clin Genet; 2007 Apr;71(4):354-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Should NF2 mutation screening be undertaken in patients with an apparently isolated vestibular schwannoma?
  • Early onset of vestibular schwannoma (VS) is associated with the inherited condition neurofibromatosis type 2 (NF2).
  • [MeSH-major] Genes, Neurofibromatosis 2. Mutation. Neuroma, Acoustic / genetics

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  • (PMID = 17470137.001).
  • [ISSN] 0009-9163
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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13. Tufarelli D, Meli A, Alesii A, De Angelis E, Badaracco C, Falcioni M, Sanna M: Quality of life after acoustic neuroma surgery. Otol Neurotol; 2006 Apr;27(3):403-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality of life after acoustic neuroma surgery.
  • OBJECTIVE: The aim of this study is to assess patients' quality of life after acoustic neuroma surgery, and if some patients' characteristics, parameters of tumor and surgical parameters affect patients' quality of life.
  • PATIENTS: A group of 386 patients who underwent acoustic neuroma surgery.
  • INTERVENTION: Patients included were derived from a population of 459 subjects operated for acoustic neuroma by the Otologic Group of Piacenza.
  • Our data indicate that an early surgical approach for intrameatal tumor is better than waiting for an increase in the tumor size.
  • A "wait-and-scan" strategy for extrameatal neuromas which do not affect the brainstem is preferable, since these patients have a worsening of their quality of life after surgery independently of the tumor size.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life

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  • (PMID = 16639281.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Hastan D, Godefroy WP, Malessy MJ, van der Mey AG: Establishing a method to predict the outcome of vestibular schwannoma surgery based on one's own results. Clin Otolaryngol; 2007 Oct;32(5):346-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishing a method to predict the outcome of vestibular schwannoma surgery based on one's own results.
  • OBJECTIVES: To establish a prognostication method based on our own results of vestibular schwannoma surgery.
  • PARTICIPANTS: 141 ambulatory patients operated for unilateral vestibular schwannoma by the translabyrinthine approach in the period 1996--2003.
  • MAIN OUTCOME MEASURES: Facial impairment defined by House Brackmann grade III-VI, and the relation with tumor size.
  • RESULTS: For our institution we found that in a range of tumor sizes the tumor size of 17.5 mm was the cut-off point associated with highest sensitivity and specificity values available concerning the prediction of facial impairment, these were 0.86 and 0.61.
  • In vestibular schwannoma surgery this leads to more precise predictions concerning outcome, as we have demonstrated for the facial function.
  • [MeSH-major] Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 17883553.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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15. Likhterov I, Allbright RM, Selesnick SH: LINAC radiosurgery and radiotherapy treatment of acoustic neuromas. 2007. Neurosurg Clin N Am; 2008 Apr;19(2):345-65, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] LINAC radiosurgery and radiotherapy treatment of acoustic neuromas. 2007.
  • This article provides an introduction to radiation therapy as it applies to intracranial tumors.
  • It also provides a review of the natural growth progression of acoustic neuromas and accuracy of tumor size determination.
  • Literature on the use of linear accelerator stereotactic radiosurgery and fractionated radiotherapy in acoustic neuroma management is reviewed and summarized.
  • Specifically, the rates of reported tumor control, hearing preservation, facial and trigeminal nerve complications, and hydrocephalus are analyzed.
  • Although the complication rates associated with linear accelerator therapy are relatively low, hearing preservation is poor and acoustic neuroma control is variable.
  • [MeSH-major] Neuroma, Acoustic / history. Radiosurgery / history

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  • (PMID = 18534344.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Likhterov I; Allbright RM; Selesnick SH
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16. Skrivan J, Betka J, Zverina E, Vrabec P, Chovanec M, Borský I: Complicated decisionmaking in indications for auditory brainstem implant (ABI) in a patient with neurofibromatosis 2. Prague Med Rep; 2007;108(3):256-62
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  • A case of an accidental finding of neurofibromatosis 2 in a practically asymptomatic patient is described.
  • Various therapeutic modalities, including restoration of hearing after vestibular schwannoma surgery with an auditory brainstem implant (ABI), are considered.
  • [MeSH-major] Auditory Brain Stem Implants. Neurofibromatosis 2 / surgery

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  • (PMID = 18399063.001).
  • [ISSN] 1214-6994
  • [Journal-full-title] Prague medical report
  • [ISO-abbreviation] Prague Med Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
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17. Brackmann DE, Cullen RD, Fisher LM: Facial nerve function after translabyrinthine vestibular schwannoma surgery. Otolaryngol Head Neck Surg; 2007 May;136(5):773-7
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  • [Title] Facial nerve function after translabyrinthine vestibular schwannoma surgery.
  • OBJECTIVES: To evaluate the long-term facial function of patients after translabyrinthine vestibular schwannoma [VS] surgery and identify factors that influence these outcomes.
  • Patient and tumor characteristics as well as perioperative complications are described.
  • Patients with smaller tumors have significantly better postoperative facial function than those with larger tumors.
  • [MeSH-major] Ear, Inner / surgery. Facial Nerve / physiopathology. Facial Paralysis / diagnosis. Facial Paralysis / physiopathology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Craniotomy. Disease Progression. Female. Follow-Up Studies. Humans. Male. Microsurgery. Middle Aged. Prevalence. Retrospective Studies. Surveys and Questionnaires


18. Lassaletta L, Alfonso C, Del Rio L, Roda JM, Gavilan J: Impact of facial dysfunction on quality of life after vestibular schwannoma surgery. Ann Otol Rhinol Laryngol; 2006 Sep;115(9):694-8
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  • [Title] Impact of facial dysfunction on quality of life after vestibular schwannoma surgery.
  • OBJECTIVES: This study was performed to evaluate the impact of facial dysfunction on quality of life in patients who underwent surgery for vestibular schwannoma.
  • METHODS: We performed a retrospective review of 95 patients who underwent removal of a unilateral vestibular schwannoma.
  • CONCLUSIONS: An overestimation of the effect of facial paralysis after vestibular schwannoma resection may exist on the surgeon's part.
  • Detailed information about the possibility of hearing loss, vestibular problems, and pain must be given to all patients.
  • [MeSH-major] Facial Paralysis / psychology. Neuroma, Acoustic / surgery. Quality of Life

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  • (PMID = 17044542.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Magliulo G, Stasolla A, Parrotto D, Marini M: Modified translabyrinthine approach and hearing preservation: imaging evaluation. J Laryngol Otol; 2007 Aug;121(8):736-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To establish if the computed tomography (CT) and magnetic resonance imaging (MRI) appearances of the vestibule, after the removal of vestibular schwannoma by a modified translabyrinthine approach, correlate with a successful outcome, defined as hearing preservation.
  • MATERIALS AND METHODS: Our study group consisted of 16 patients with vestibular schwannoma.
  • On MRI scans, the schwannoma, including the intracanalicular segment, were less than 2 cm in size in all the patients.
  • In the remaining nine patients, the schwannoma had spread to involve two-thirds of the meatus, sparing its lateral third.
  • RESULTS: The schwannoma was completely removed in all patients.
  • The MRI vestibular signal on the T2-weighted images was well depicted only in patients with hearing preservation.
  • Bony vestibular integrity was observed in the CT scans of all cases with hearing preservation, and also in three cases with failure of hearing preservation.
  • CONCLUSION: Our results confirm that total isolation and maintenance of an anatomically intact vestibule, as depicted by MRI examination, is one of the fundamental factors for successful preservation of hearing function following modified translabyrinthine approach schwannoma removal.
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures. Vestibule, Labyrinth / surgery

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  • (PMID = 17319988.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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20. Saeed SR, Suryanarayanan R, Dezso A, Ramsden RT: Vestibular schwannoma management: current practice amongst UK otolaryngologists--time for a national prospective audit. Ann R Coll Surg Engl; 2006 Sep;88(5):490-5
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  • [Title] Vestibular schwannoma management: current practice amongst UK otolaryngologists--time for a national prospective audit.
  • INTRODUCTION: It is generally agreed that the successful management of a vestibular schwannoma (VS) usually involves close collaboration between a neuro-otologist and neurosurgeon.
  • [MeSH-major] Neuroma, Acoustic / surgery. Otorhinolaryngologic Surgical Procedures / standards. Professional Practice / standards

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  • [Cites] J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):147-8 [10896683.001]
  • [Cites] J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):161-6 [10896686.001]
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  • (PMID = 17002858.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1964657
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21. Clarke L: Neurofibromatosis 2--a family journey. Can J Neurosci Nurs; 2009;31(4):7-14
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  • Neurofibromatosis 2 (NF2) is a complex autosomal dominant genetic disorder, now recognized to occur as a result of a mutation on chromosome 22.
  • NF2's clinical manifestations of bilateral vestibular schwannomas and multiple other nervous system tumours have far-reaching implications for patients and families diagnosed with this challenging disorder.
  • The Atlantic Lateral Skull Base Clinic in Halifax follows approximately 400 patients with unilateral vestibular schwannomas and other skull base lesions.
  • [MeSH-minor] Adaptation, Psychological. Adolescent. Adult. Aged. Attitude to Health. Female. Genetic Testing. Humans. Male. Meningioma / genetics. Middle Aged. Neuroma, Acoustic / genetics. Nova Scotia. Patient Care Team / organization & administration. Referral and Consultation

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  • (PMID = 20085115.001).
  • [ISSN] 1913-7176
  • [Journal-full-title] Canadian journal of neuroscience nursing
  • [ISO-abbreviation] Can J Neurosci Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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22. Isaacson B, Telian SA, El-Kashlan HK: Facial nerve outcomes in middle cranial fossa vs translabyrinthine approaches. Otolaryngol Head Neck Surg; 2005 Dec;133(6):906-10
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  • [Title] Facial nerve outcomes in middle cranial fossa vs translabyrinthine approaches.
  • OBJECTIVE: To compare the final facial nerve outcomes between middle cranial fossa (MCF) vs translabyrinthine (TL) resection of size-matched vestibular schwannomas.
  • All patients who underwent resection utilizing either MCF or TL approaches with tumors 18 mm or smaller and complete data were included in the analysis.
  • One-week-postoperative and final facial nerve examinations were compared in the two surgical groups.
  • Patients were separately analyzed in subgroups: tumors smaller than 10 mm and those that were between 10 and 18 mm.
  • RESULTS: The tumor size range for the MCF group was 3-18 mm while it was 4-18 mm for the TL group.
  • No statistically significant difference was found in facial nerve outcomes between the two surgical groups, at the first postoperative visit week and at last follow-up.
  • CONCLUSION: Facial nerve outcomes are similar using TL and MCF approaches for resection of vestibular schwannomas up to 18 mm in size.
  • SIGNIFICANCE: Patients undergoing the MCF approach for hearing preservation can be counseled that there is no increased risk of permanent facial nerve weakness, compared to the TL approach.
  • [MeSH-major] Cranial Fossa, Middle / surgery. Ear, Inner / surgery. Facial Nerve / physiopathology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16360512.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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23. Verma S, Anthony R, Tsai V, Taplin M, Rutka J: Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma. Clin Otolaryngol; 2009 Oct;34(5):438-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma.
  • OBJECTIVE: To determine whether economic costs associated with a conservative management strategy for unilateral acoustic neuroma offer an economic advantage over active management options.
  • PARTICIPANTS: 72 patients (32 males, 40 females) aged 36 to 78 years with unilateral acoustic neuroma were assigned initially to a conservative management strategy.
  • CONCLUSION: An economic advantage can be demonstrated for the conservative management of acoustic neuromas compared to microsurgical removal and gamma knife radiotherapy on the proviso that no increase in active treatment complications arose from continued tumour growth during the period of observation.
  • [MeSH-major] Neuroma, Acoustic / economics. Neuroma, Acoustic / therapy

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  • [CommentIn] Clin Otolaryngol. 2010 Feb;35(1):69-70; author reply 70-1 [20447172.001]
  • (PMID = 19793276.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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24. Zverina E: [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management]. Cas Lek Cesk; 2010;149(6):269-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management].
  • [Transliterated title] Neurinom akustiku--vestibulární schwannom--osobní pohled na nejmodernejsí postupy v jeho lécbe.
  • Acoustic neuroma, properly called vestibular schwannoma, arises from the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve as the most frequent tumour of the posterior fossa.
  • Its incidence is estimated at 1.2 vestibular schwannoma per a population of 100,000/year.
  • As to size, vestibular schwannoma is classified into grades I to IV.
  • About one third of small vestibular schwannoma show hardly any growth, the larger ones grow aggressively.
  • The author's conclusion is based on 33 years of experience with hundreds of surgically treated vestibular schwannoma (now at the ENT Department of Head and Neck Surgery, CU 1st Medical Faculty and FN Teaching Hospital, Prague Motol).
  • Irradiation for larger vestibular schwannoma is decreasingly efficacious.
  • 3. Microsurgery with intraoperative monitoring of facial and acoustic nerve function offers scope for radical removal of vestibular schwannoma of any size (grades I-IV) and for the preservation of facial nerve function and, of late, hearing, too.
  • [MeSH-major] Neuroma, Acoustic


25. Régis J, Roche PH, Delsanti C, Thomassin JM, Ouaknine M, Gabert K, Pellet W: Modern management of vestibular schwannomas. Prog Neurol Surg; 2007;20:129-41
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  • [Title] Modern management of vestibular schwannomas.
  • Within the last 3 decades, microsurgery and stereotactic radiosurgery (SRS) have become well-established management options for vestibular schwannomas (VSs).
  • A long-term tumor control rate of 97%, transient facial palsy lower than 1%, and a probability of functional hearing preservation between 50 and 95% was achieved in this large series of patients treated with state-of-the-art SRS.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery

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  • (PMID = 17317981.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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26. Donzelli R, Maiuri F, Peca C, Cavallo LM, Motta G, de Divitiis E: Microsurgical repair of the facial nerve. Zentralbl Neurochir; 2005 May;66(2):63-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical repair of the facial nerve.
  • OBJECTIVE: To report a series of 18 patients who underwent microsurgical repair of the facial nerve using different techniques and to discuss the indications and results of facial reinnervation procedures.
  • 'These included classic hypoglossal-facial anastomosis in 13 cases, one-stage hemihypoglossal-intratemporal facial nerve anastomosis and translabyrinthine removal of residual intra-canalar acoustic schwannoma in 3, hemihypoglossal-facial nerve anastomosis in one, and neurotization of facial muscles through a nerve graft in one.
  • The use of the intratemporal facial nerve is indicated when removal of an intra-canalar residual schwannoma must also be performed.
  • The neurotization of the facial muscles through a nerve graft may be used when there is no distal trunk of the facial nerve available for the anastomosis.
  • [MeSH-major] Facial Nerve / surgery. Neurosurgical Procedures
  • [MeSH-minor] Adult. Anastomosis, Surgical. Atrophy. Ear, Inner / surgery. Facial Muscles / innervation. Facial Muscles / surgery. Facial Paralysis / etiology. Facial Paralysis / surgery. Female. Humans. Hypoglossal Nerve / surgery. Male. Microsurgery. Middle Aged. Nerve Tissue / transplantation. Neuroma, Acoustic / surgery. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / surgery. Tongue / pathology. Tongue Diseases / etiology. Treatment Outcome

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  • (PMID = 15846533.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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27. Doherty JK, Friedman RA: Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg; 2006 Oct;14(5):305-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Controversies in building a management algorithm for vestibular schwannomas.
  • PURPOSE OF REVIEW: The present review examines the various mainstream treatment options, benefits and risks, and controversies involved in developing a management algorithm for treatment of vestibular schwannoma.
  • RECENT FINDINGS: Advances in microsurgery and radiosurgery have made tremendous contributions to management of vestibular schwannoma; however, considerable controversy still exists.
  • The auditory and facial nerve functional outcomes have improved with use of intraoperative monitoring for vestibular schwannoma removal and with lower radiosurgery doses; however, risks to the facial and auditory nerves still exist.
  • Observing vestibular schwannomas for growth with serial magnetic resonance imaging is an increasingly popular option for small vestibular schwannomas that allows patients to enjoy hearing and facial function.
  • SUMMARY: The risks and benefits of each treatment option must be weighed for each patient, and management decisions regarding vestibular schwannomas should be individualized for each patient depending on tumor anatomy, patient preferences, and symptoms.
  • [MeSH-major] Algorithms. Ear, Inner / surgery. Neuroma, Acoustic / therapy
  • [MeSH-minor] Cochlear Nerve / physiology. Facial Nerve / physiology. Hearing Loss / prevention & control. Humans. Magnetic Resonance Imaging. Microsurgery. Neurofibromatosis 2 / surgery. Neurofibromatosis 2 / therapy. Radiosurgery. Treatment Outcome

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  • [CommentIn] Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):297-8 [16974140.001]
  • (PMID = 16974142.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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28. Roos DE, Brophy BP, Bhat MK, Katsilis ES: Update of radiosurgery at the Royal Adelaide Hospital. Australas Radiol; 2006 Apr;50(2):158-67
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  • This is an update of the Royal Adelaide Hospital radiosurgery experience between November 1993 and December 2004 comprising 165 patients with 168 intracranial lesions.
  • The commonest lesions were acoustic neuroma (65), arteriovenous malformation (58), solitary brain metastasis (23) and meningioma (14).
  • Radiosurgery provides an elegant, non-invasive alternative to neurosurgery and conventional external beam radiotherapy for many benign and malignant brain tumours.
  • [MeSH-major] Brain Neoplasms / surgery. Hospitals / utilization. Lung Neoplasms / secondary. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Outcome Assessment (Health Care) / statistics & numerical data. Radiosurgery / methods. Utilization Review
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Brain / pathology. Brain / radiography. Brain / surgery. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Intracranial Arteriovenous Malformations / surgery. Male. Middle Aged. Prospective Studies. South Australia. Survival Analysis


29. Teppo H, Heikkinen J, Laitakari K, Alho OP: Diagnostic delays in vestibular schwannoma. J Laryngol Otol; 2009 Mar;123(3):289-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic delays in vestibular schwannoma.
  • OBJECTIVES: The literature on delays in vestibular schwannoma diagnosis is from the era before the routine use of magnetic resonance imaging.
  • METHODS: A two-centre study was conducted, including 91 consecutive vestibular schwannoma patients diagnosed between 1992 and 2006.
  • CONCLUSIONS: Delays in the diagnosis of vestibular schwannoma have shortened since the introduction of magnetic resonance imaging.
  • [MeSH-major] Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Finland. Humans. Magnetic Resonance Imaging. Male. Medical Audit. Middle Aged. Retrospective Studies. Time Factors. Tumor Burden. Young Adult

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  • (PMID = 18577273.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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30. Nagano O, Serizawa T, Higuchi Y, Matsuda S, Sato M, Yamakami I, Okiyama K, Ono J, Saeki N: Tumor shrinkage of vestibular schwannomas after Gamma Knife surgery: results after more than 5 years of follow-up. J Neurosurg; 2010 Dec;113 Suppl:122-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor shrinkage of vestibular schwannomas after Gamma Knife surgery: results after more than 5 years of follow-up.
  • OBJECT: The authors prospectively analyzed volume changes in vestibular schwannomas (VSs) after Gamma Knife surgery (GKS).
  • RESULTS: The mean tumor volume at GKS was 2.5 cm3 (range 0.1–13.2 cm3).
  • The lesions were irradiated by directing a mean dose of 12.0 Gy (range 10.5–13.0 Gy) to the tumor margin, which was located at the mean 52.2% isodose line (range 50%–67% isodose line).
  • Peak tumor volume expansion was most frequently observed at 8.6 months after GKS and averaged 58% (range 0%–613%).
  • Five years after GKS, the mean reduction in tumor volume was 31%, and 9 tumors still remained larger than their initial volumes.
  • Tumors that homogeneously enhanced on MR images displayed less shrinkage than other tumors.
  • These results indicate that careful serial follow-up is necessary for patients who harbor tumors that display homogeneous enhancement on MR images and patients whose tumors continue to expand in size after GKS. (DOI: 10.3171/2010.8.GKS10960)
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Echo-Planar Imaging. Female. Follow-Up Studies. Humans. Longitudinal Studies. Male. Middle Aged. Paresthesia / etiology. Prognosis. Treatment Outcome. Trigeminal Nerve Diseases / etiology

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  • (PMID = 21222292.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Scarlett A, Bird P, Macfarlane M: Conductive hearing loss after removal of acoustic neuroma. Otol Neurotol; 2008 Jun;29(4):553-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conductive hearing loss after removal of acoustic neuroma.
  • OBJECTIVE: To report 4 patients who have developed a conductive and/or mixed hearing loss due to dehiscence of the inner ear after retrosigmoid approach for removal of acoustic neuroma.
  • PATIENTS: Four patients who presented with conductive and/or mixed hearing loss after retrosigmoid approach for removal of acoustic neuroma.
  • CONCLUSION: The occurrence of conductive hearing loss after the surgical removal of an acoustic neuroma has not previously been documented.
  • Computed tomographic scan of the temporal bones showing inner ear dehiscence may explain this finding.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / surgery. Hearing Loss, Conductive / etiology. Hearing Loss, Conductive / physiopathology. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology. Vestibulocochlear Nerve Diseases / complications. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Acoustic Impedance Tests. Adult. Aged. Audiometry. Female. Hearing Aids. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Otologic Surgical Procedures. Otoscopy. Petrous Bone / pathology. Speech Perception. Tomography, X-Ray Computed


32. Parietti-Winkler C, Gauchard GC, Simon C, Perrin PP: Long-term effects of vestibular compensation on balance control and sensory organisation after unilateral deafferentation due to vestibular schwannoma surgery. J Neurol Neurosurg Psychiatry; 2010 Aug;81(8):934-6
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  • [Title] Long-term effects of vestibular compensation on balance control and sensory organisation after unilateral deafferentation due to vestibular schwannoma surgery.
  • The time-course of central adaptive mechanisms after vestibular schwannoma surgical removal allows, 3 months after surgery (middle term), a satisfactory recovery of balance control.
  • This longitudinal prospective study aimed to assess the long-term effects of vestibular compensation on balance control and sensory organisation in patients operated on for vestibular schwannoma.
  • Thirty-six patients with vestibular schwannoma underwent vestibular and sensory organisation tests, shortly before and 3 months, 6 months and 1 year after surgery.
  • Postural control performances improved 3 months after surgery compared with before surgery; they continued to improve at 6 and 12 months after surgery, especially in conditions highly soliciting vestibular information.
  • In the long term, strategies based on sensorimotor and/or behavioural substitution seem to be reinforced and fine-tuned, particularly in complex postural situations, for which only vestibular information is reliable to control balance.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Postural Balance / physiology. Sensation / physiology. Vestibule, Labyrinth / physiopathology. Vestibule, Labyrinth / surgery. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Adult. Denervation. Female. Follow-Up Studies. Humans. Longitudinal Studies. Male. Middle Aged. Postoperative Period. Prospective Studies. Reflex, Vestibulo-Ocular / physiology. Vestibular Function Tests

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  • (PMID = 20682722.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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33. Patni AH, Kartush JM: Staged resection of large acoustic neuromas. Otolaryngol Head Neck Surg; 2005 Jan;132(1):11-9
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  • [Title] Staged resection of large acoustic neuromas.
  • OBJECTIVE: Surgical removal of large (>3 cm) acoustic neuromas is associated with poor long-term facial nerve function results and higher complication rates.
  • This study analyzes whether long term facial nerve function and the incidence of neurological and vascular complications is improved by resection of large acoustic neuromas in 2 or 3 stages.
  • PATIENTS AND METHODS: Among 660 patients who underwent surgical resection of acoustic neuromas between 1989 and 2002 by the senior author (J.M.K.
  • ), 34 (5%) patients underwent a staged resection of their large-sized tumors: stage I via a retrosigmoid craniotomy and stage II via a translabyrinthine approach.
  • Tumor size, completeness of tumor removal, tumor recurrence, facial nerve function, and any complications were noted.
  • RESULTS: The average tumor size was 4.4 cm with a mean postoperative length of follow-up of 6 years after the last surgery.
  • There were no tumor recurrences on follow-up MRI scans.
  • CONCLUSION: In conjunction with the reported technical refinements, staged resection of large tumors significantly reduces morbidity and improves long-term facial nerve function.
  • [MeSH-major] Neuroma, Acoustic / surgery
  • [MeSH-minor] Facial Nerve / physiology. Facial Nerve Diseases / prevention & control. Female. Follow-Up Studies. Humans. Male. Otologic Surgical Procedures / adverse effects. Otologic Surgical Procedures / methods. Postoperative Complications / epidemiology. Postoperative Complications / etiology. Retrospective Studies

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  • (PMID = 15632903.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. De la Cruz A, Teufert KB: Transcochlear approach to cerebellopontine angle and clivus lesions: indications, results, and complications. Otol Neurotol; 2009 Apr;30(3):373-80
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  • Patients were grouped by whether the facial nerve was mobilized (TC, n = 15) or not (TO, n = 25).
  • MAIN OUTCOME MEASURES: Indications, postoperative outcomes, and complications including tumor removal and facial nerve status (House-Brackmann grade).
  • RESULTS: Forty percent of all TC patients were meningiomas, whereas 36% of all TO patients were cochlear neuromas.
  • The remainder included tumors associated with NF2, acoustic tumors, malignancies, and other lesions.
  • Complete removal was achieved in 92.5% of tumors.
  • Of all patients, 42% and 55% had normal facial nerve function at the time of hospital discharge and follow up, respectively.
  • Moreover, 22% underwent a facial nerve reanastomosis procedure.
  • CONCLUSION: The TC and TO approaches provide access to midline intradural lesions, intradural petroclival tumors, and cerebellopontine angle tumors and cholesteatomas arising anterior to the internal auditory canal, without using brain retractors.
  • Total tumor removal, including its base and blood supply, is possible.
  • Facial weakness is frequent when the facial nerve is rerouted, but excellent facial nerve results are accomplished with the TO approach.
  • With these approaches, recurrence israre when all tumor has been removed.
  • [MeSH-minor] Adolescent. Adult. Aged. Carotid Arteries / anatomy & histology. Child, Preschool. Data Interpretation, Statistical. Ear Canal / anatomy & histology. Ear Canal / surgery. Facial Nerve / physiology. Facial Nerve / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / surgery. Middle Aged. Neoplasm Recurrence, Local. Treatment Outcome. Young Adult

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  • (PMID = 19318889.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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35. Bouetel V, Lescanne E, François P, Jan M, Morinière S, Robier A: [Evolution of facial nerve prognosis in vestibular schwannoma surgery by translabyrinthine approach]. Rev Laryngol Otol Rhinol (Bord); 2008;129(1):27-33
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  • [Title] [Evolution of facial nerve prognosis in vestibular schwannoma surgery by translabyrinthine approach].
  • [Transliterated title] Evolution du pronostic du nerf facial dans la chirurgie du neurinome de l'acoustique par voie translabyrinthique.
  • PATIENTS AND METHODS: A series of 248 patients operated of an unilateral vestibular schwannoma has been reviewed.
  • The other factors are the hearing level, deafness duration, trigeminal nerve involved, vestibular status and ABR desynchronization.
  • CONCLUSION: The positive predictive factors are usually correlated with the size of the tumour This implies the necessity of an early diagnosis of the schwannomas.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, Inner / surgery. Facial Nerve / physiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Evoked Potentials, Auditory, Brain Stem / physiology. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / physiopathology. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Severity of Illness Index

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  • (PMID = 18777766.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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36. Hong SJ, Lee JH, Jung SH, Park CH, Hong SM: Can cochlear function be preserved after a modified translabyrinthine approach to eradicate a huge cholesteatoma extending to the petrous apex? Eur Arch Otorhinolaryngol; 2009 Aug;266(8):1191-7
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  • We concluded that the modified translabyrinthine approach is useful for preserving hearing postoperatively when a huge cholesteatoma exists involving the petrous region or a vestibular schwannoma in the internal auditory canal or cerebellopontine angle.
  • [MeSH-major] Catheter Ablation / methods. Cholesteatoma, Middle Ear / surgery. Cochlea / physiopathology. Cochlear Nerve / surgery. Hearing / physiology. Petrous Bone / surgery. Vestibule, Labyrinth / surgery

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  • [Cites] Laryngoscope. 2000 May;110(5 Pt 1):779-86 [10807357.001]
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  • (PMID = 19034472.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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37. Tan M, Myrie OA, Lin FR, Niparko JK, Minor LB, Tamargo RJ, Francis HW: Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007. Laryngoscope; 2010 Jan;120(1):144-9
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  • [Title] Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007.
  • OBJECTIVES/HYPOTHESIS: To assess trends in the management of unilateral vestibular schwannomas over an 11-year period and to identify disease- and provider-related influences.
  • METHODS: Subjects presented to the Department of Otolaryngology-Head and Neck Surgery and the Department of Neurosurgery for management of unilateral vestibular schwannoma from 1997 through 2007, with at least two visits within the first year of presentation.
  • The proportion of patients for whom initial management consisted of observation, surgical resection, or radiation therapy was determined, and the relative influence of study year, patient age, hearing status, and tumor size was analyzed.
  • There were no changes in mean age or hearing status at diagnosis, but mean tumor size declined significantly.
  • Tumors that were surgically removed were on average 11.6 mm larger than those that were observed.
  • The increasing frequency over time of observation relative to surgery was significant even after controlling for age, hearing status, and tumor size.
  • CONCLUSIONS: Among patients managed by our center, there has been a significant shift in management of vestibular schwannomas over the last decade, with increasing tendency towards observation.
  • [MeSH-major] Ear Neoplasms / therapy. Neuroma, Acoustic / therapy

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  • (PMID = 19877188.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Vorasubin N, Sang U H, Mafee M, Nguyen QT: Glossopharyngeal schwannomas: a 100 year review. Laryngoscope; 2009 Jan;119(1):26-35
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  • [Title] Glossopharyngeal schwannomas: a 100 year review.
  • OBJECTIVES: To review the literature on glossopharyngeal schwannomas with a focus on clinical presentation, radiologic/audiologic characteristics, and management options, and to propose a mechanism explaining the nature of vestibulocochlear dysfunction seen with these tumors.
  • METHODS: English literature search for cases of primary isolated glossopharyngeal schwannomas and chart review of two new cases.
  • RESULTS: A total of 42 glossopharyngeal schwannoma cases between 1908-2008 were reviewed.
  • Tumors can occur anywhere along the CNIX; however, the majority of symptomatic cases are intracranial/intraosseous, which present with vestibulocochlear dysfunction.
  • Reviewed cases typically described the caliber of CNVII and VIII on CT/MRI as normal.
  • We present a case where notching and displacement of CNVIII by the tumor can be appreciated on MRI, allowing for the first correlation between clinical symptoms and imaging findings.
  • Mid frequency SNHL was prevalent in contrast to the high-frequency pattern typical of vestibular schwannomas.
  • Tonotopic studies of CNVIII mapped low-to-mid frequency fibers along the posterior medial surface corresponding to the area of greatest compression by glossopharyngeal schwannomas.
  • CONCLUSION: Glossopharyngeal schwannomas usually present with vestibulocochlear rather than glossopharyngeal symptoms, likely due to CNVIII compression and displacement by tumor, which can be better appreciated with modern imaging.
  • The tumor's location posterior and medial to CNVIII combined with the complex CNVIII tonotopic organization may account for the preferential mid-frequency hearing loss seen in these patients.
  • [MeSH-major] Glossopharyngeal Nerve Diseases / diagnosis. Glossopharyngeal Nerve Diseases / surgery. Neurilemmoma / diagnosis. Neurilemmoma / surgery

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  • (PMID = 19117318.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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39. Obrebowski A, Wiskirska-Woźnica B, Czerniejewska H: [Binaural asymmetric sensorineural hearing loss in audiological practice]. Otolaryngol Pol; 2010 Nov-Dec;64(6):382-4
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  • After audiological examination 14% of this patients were qualified for MRI investigation, in 2 (3%) of them acoustic neurinoma was found.

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  • (PMID = 21302506.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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40. Okamoto K, Furusawa T, Ishikawa K, Sasai K, Tokiguchi S: Focal T2 hyperintensity in the dorsal brain stem in patients with vestibular schwannoma. AJNR Am J Neuroradiol; 2006 Jun-Jul;27(6):1307-11
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  • [Title] Focal T2 hyperintensity in the dorsal brain stem in patients with vestibular schwannoma.
  • BACKGROUND AND PURPOSE: The vestibular nucleus cannot be visualized on MR imaging, but some patients with vestibular schwannoma show a tiny area of hyperintensity in the dorsal brain stem on T2-weighted images.
  • The aim of this study was to determine whether this tiny area is characteristic of vestibular schwannoma.
  • METHODS: We retrospectively reviewed the postoperative MR images of 53 patients with cerebellopontine angle tumor.
  • Surgical and histopathologic diagnosis was vestibular schwannoma (41/53 = 77%), meningioma (7/53 = 13%), epidermoid cyst (3/53 = 6%), glioma with exophytic growth (1/53 = 2%), and chordoma (1/53 = 2%).
  • RESULTS: A tiny area of hyperintensity was observed at the lateral angle of the fourth ventricle floor in 6 patients (3 men, 3 women; age range, 24-54 years; mean age, 43 years) with vestibular schwannoma larger than 2 cm in maximal diameter on both FSE T2-weighted and CISS images.
  • CONCLUSION: Because the location of the area of hyperintensity is coincident with the vestibular nucleus, the hyperintensity may represent degeneration of the nucleus.
  • If such hyperintensity is seen in a patient with a large cerebellopontine angle tumor, a diagnosis of vestibular schwannoma is suggested.
  • [MeSH-major] Brain Stem / pathology. Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis

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  • (PMID = 16775286.001).
  • [ISSN] 0195-6108
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Hansen MR, Clark JJ, Gantz BJ, Goswami PC: Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiation. Laryngoscope; 2008 Jun;118(6):1023-30
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  • [Title] Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiation.
  • OBJECTIVE: For vestibular schwannomas (VSs) that require treatment, options are limited to microsurgery or irradiation (IR).
  • METHODS: Primary cultures of VS cells were derived from acutely resected tumors.
  • Cell proliferation was determined by BrdU uptake and apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL).
  • RESULTS: IR induces VS cell cycle arrest and apoptosis in doses greater than 20 Gy, demonstrating that VS cells are relatively radioresistant.
  • Inhibition of ErbB2, which decreases VS cell proliferation, protects VS cells from radiation-induced apoptosis, while NRG-1, an ErbB2 ligand and VS cell mitogen, increases radiation-induced VS cell apoptosis.
  • [MeSH-major] Ear Neoplasms / pathology. Neuroma, Acoustic / pathology. Receptor, ErbB-2 / physiology. Receptor, ErbB-2 / radiation effects. Vestibular Diseases / pathology
  • [MeSH-minor] Apoptosis. Bromodeoxyuridine / metabolism. Cell Division. DNA Damage. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Neuregulin-1 / pharmacology. Prospective Studies. Signal Transduction / physiology. Signal Transduction / radiation effects. Tumor Cells, Cultured / radiation effects

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  • (PMID = 18520822.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / K08 DC006211; United States / NIDCD NIH HHS / DC / K08 DC006211
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neuregulin-1; EC 2.7.10.1 / Receptor, ErbB-2; G34N38R2N1 / Bromodeoxyuridine
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42. Shih C, Tseng FY, Yeh TH, Hsu CJ, Chen YS: Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma. Otolaryngol Head Neck Surg; 2009 Dec;141(6):695-700
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  • [Title] Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma.
  • OBJECTIVE: To analyze auditory brainstem response (ABR) data in patients with vestibular schwannomas (VS) in an effort to identify correlations between abnormal ABR parameters and tumor size.
  • Average VS tumor size was 2.48 +/- 1.31 cm.
  • Tumor size was positively correlated with pure-tone average (P = 0.0106) and with the total number of bilateral abnormal ABR parameters (P = 0.004).
  • CONCLUSIONS: We identified a correlation between ABR parameters and VS tumor size.
  • An ipsilateral ILD-I-V greater than 0.2 ms was sensitive for detecting vs. Abnormal contralateral wave V and interpeak III-V latency indicated a tumor size potentially larger than 2 cm.
  • [MeSH-major] Evoked Potentials, Auditory, Brain Stem / physiology. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry, Pure-Tone. Cross-Sectional Studies. Female. Humans. Linear Models. Male. Middle Aged. Retrospective Studies. Vestibular Function Tests

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  • (PMID = 19932840.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Pons Y, Gauthier J, Dagain A, Conessa C, Clement P, Desgeorges M, Poncet JL: [Long-term results of facial palsy's rehabilitation by end-to-end hypoglossal-facial anastomosis]. Rev Laryngol Otol Rhinol (Bord); 2009;130(3):169-74
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  • [Transliterated title] Résultats à long terme de la réhabilitation des paralysies faciales périphériques par anastomose hypoglosso-faciale termino-terminale.
  • PATIENTS AND METHODS: In this retrospective study, 11 patients (8 males and 3 females) with a complete facial palsy (grade VI House-Brackmann) due to an otoneurosurgery performed between 1985 and 2006 (6 vestibular schwannomas, 1 facial schwannoma of the geniculate ganglion and 4 meningiomas) were evaluated (with the help of an auto-questionnary, a physical exam and electromyography) between July and september in 2008.
  • [MeSH-major] Facial Nerve / surgery. Facial Paralysis / rehabilitation. Hypoglossal Nerve / surgery

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  • (PMID = 20345073.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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44. Curtin HD, Hirsch WL Jr: Imaging of acoustic neuromas. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):175-205, v
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  • [Title] Imaging of acoustic neuromas. 1992.
  • Diagnosis of acoustic neuromas has been simplified considerably by computed tomography (CT) and magnetic resonance imaging (MRI).
  • Either enhanced method will visualize almost every acoustic neuroma.
  • Currently, a gadolinium-enhanced MRI scan is considered an accurate indicator of whether or not an individual has an acoustic neuroma, although there have been false-positive enhanced MRI scans recently reported.
  • [MeSH-major] Magnetic Resonance Imaging / history. Neuroma, Acoustic / history. Tomography, X-Ray Computed / history

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  • (PMID = 18534334.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Curtin HD; Hirsch WL Jr
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45. Saliba I, Martineau G, Chagnon M: Asymmetric hearing loss: rule 3,000 for screening vestibular schwannoma. Otol Neurotol; 2009 Jun;30(4):515-21
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  • [Title] Asymmetric hearing loss: rule 3,000 for screening vestibular schwannoma.
  • OBJECTIVE: To assess the diagnostic yield of audiograms associated to electronystagmography (ENG) for screening vestibular schwannomas (VSs), to determine what definition of asymmetric sensorineural hearing loss (ASNHL) fits best for the diagnosis of VS, and to determine if cochleovestibular symptoms and atherosclerotic potential risk factors play a role in the VS screening.
  • RESULTS: The most revealing data were the mean ASNHL at 3,000 Hz (p < 0.001), the interaural SDS asymmetry (p < 0.001), the vestibular deficit (p < 0.049), and the absence of vertigo (p < 0.001).
  • The grade of the tumor was also related with the degree of ASNHL at 3,000 Hz.
  • [MeSH-major] Hearing Loss, Unilateral / physiopathology. Mass Screening / methods. Neuroma, Acoustic / diagnosis


46. Blettner M, Schlehofer B, Samkange-Zeeb F, Berg G, Schlaefer K, Schüz J: Medical exposure to ionising radiation and the risk of brain tumours: Interphone study group, Germany. Eur J Cancer; 2007 Sep;43(13):1990-8
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  • [Title] Medical exposure to ionising radiation and the risk of brain tumours: Interphone study group, Germany.
  • BACKGROUND: The role of exposure to low doses of ionising radiation in the aetiology of brain tumours has yet to be clarified.
  • The objective of this study was to investigate the association between medically or occupationally related exposure to ionising radiation and brain tumours.
  • METHODS: We used self-reported medical and occupational data collected during the German part of a multinational case-control study on mobile phone use and the risk of brain tumours (Interphone study) for the analyses.
  • RESULTS: For any exposure to medical ionising radiation we found odds ratios (ORs) of 0.63 (95% confidence interval (CI)=0.48-0.83), 1.08 (95% CI=0.80-1.45) and 0.97 (95% CI=0.54-1.75) for glioma, meningioma and acoustic neuroma, respectively.
  • Elevated ORs were found for meningioma (OR 2.32, 95% CI: 0.90-5.96) and acoustic neuroma (OR 6.45, 95% CI: 0.62-67.16) for radiotherapy to the head and neck regions.
  • CONCLUSION: We did not find any significant increased risk of brain tumours for exposure to medical ionising radiation.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Neoplasms, Radiation-Induced / etiology. Occupational Exposure / adverse effects

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  • (PMID = 17689954.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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47. Ahmad SM, Garcia F, Sataloff RT: Cerebellopontine angle ganglionic hamartoma: case report. Ear Nose Throat J; 2010 Mar;89(3):128-31
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  • Magnetic resonance imaging revealed a mass on the intracanalicular segment of cranial nerve VIII on the left side, consistent with acoustic schwannoma.
  • She opted for observation of the tumor.
  • At this time, a working diagnosis of facial nerve neuroma was made.
  • Otolaryngologists should be familiar with this uncommon tumor and include it in the differential diagnosis of CPA lesions.
  • [MeSH-minor] Cochlear Nerve / physiopathology. Evoked Potentials, Auditory, Brain Stem. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / etiology. Female. Humans. Middle Aged

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  • (PMID = 20229478.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P: True incidence of vestibular schwannoma? Neurosurgery; 2010 Nov;67(5):1335-40; discussion 1340
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] True incidence of vestibular schwannoma?
  • BACKGROUND: The incidence of diagnosed sporadic unilateral vestibular schwannomas (VS) has increased, due primarily to more widespread access to magnetic resonance imaging.
  • OBJECTIVE: To present updated epidemiological data on VS incidence, as well as patient age, hearing acuity, tumor size, and localization at diagnosis for the last 4 decades in an unselected population, with emphasis on developments in recent years.
  • Incidence during the period, patient sex and age, data on hearing (pure tone average and speech discrimination), and tumor size at diagnosis were retrieved from the database.
  • Mean tumor size at diagnosis decreased from 30 mm in 1979 to 10 mm in 2008, whereas hearing acuity at diagnosis has improved over the years.
  • CONCLUSION: After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
  • Whereas the sex ratio and age at diagnosis have remained grossly unchanged over the years, hearing has improved, and tumor size has decreased considerably.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

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  • (PMID = 20871439.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Hanemann CO, Bartelt-Kirbach B, Diebold R, Kämpchen K, Langmesser S, Utermark T: Differential gene expression between human schwannoma and control Schwann cells. Neuropathol Appl Neurobiol; 2006 Dec;32(6):605-14
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  • [Title] Differential gene expression between human schwannoma and control Schwann cells.
  • The mutation of a single allele of this gene causes the autosomal dominantly inherited disease neurofibromatosis type 2 (NF2), which is characterized mainly by vestibular schwannoma carrying a second hit mutation.
  • Complete lack of merlin is also found in spontaneous schwannomas and meningiomas.
  • As the events leading to schwannoma development are largely unknown we investigated the differences in gene expression between schwannoma cells from NF2 patients and normal human primary Schwann cells by cDNA array analysis.
  • By this method a total of seven genes with increased and seven genes with decreased mRNA levels in schwannoma compared with normal Schwann cells could be identified.
  • Regulated clones, some of which not been described in Schwann cells earlier, included matrix metalloproteinase's, growth factors, growth factor receptors and tyrosine kinases.
  • [MeSH-major] Gene Expression. Neurilemmoma / genetics. Neurofibromatosis 2 / genetics. Schwann Cells / physiology

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  • (PMID = 17083475.001).
  • [ISSN] 0305-1846
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger
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50. Hayhurst C, Javadpour M, O'Brien DF, Mallucci CL: The role of endoscopic third ventriculostomy in the management of hydrocephalus associated with cerebellopontine angle tumours. Acta Neurochir (Wien); 2006 Nov;148(11):1147-50; discussion 1150
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Brain Neoplasms / complications. Cerebellopontine Angle / physiopathology. Endoscopy / methods. Hydrocephalus / etiology. Hydrocephalus / surgery. Third Ventricle / surgery. Ventriculostomy / methods
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology. Neuroma, Acoustic / physiopathology. Postoperative Complications. Retrospective Studies. Treatment Outcome


51. Corona AP, Oliveira JC, Souza FP, Santana LV, Rêgo MA: Risk factors associated with vestibulocochlear nerve schwannoma: systematic review. Braz J Otorhinolaryngol; 2009 Jul-Aug;75(4):593-615
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  • [Title] Risk factors associated with vestibulocochlear nerve schwannoma: systematic review.
  • The vestibulocochlear nerve schwannoma (VS) is a benign tumor that stems from the edge of the Schwann s sheath.
  • It is considered the most frequent intracranial benign tumor, of low lethality rate and unknown etiology.
  • METHODS: electronic search of studies using the following key words: 'risk', 'schwannoma', 'vestibular', 'neuroma' and 'acoustic'.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology

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  • (PMID = 19784431.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 49
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52. Feucht M, Mautner VF, Richard G: [NF2: ocular, neural and genetic manifestations]. Klin Monbl Augenheilkd; 2005 Apr;222(4):312-6
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  • Neurofibromatosis 2 is an autosomal-dominant disease, which is characterized by vestibular schwannomas, cataract, retinal hamartomas as well as tumors of the peripheral and central nerve system, demonstrating a variety of expression.
  • The ophthalmologist plays an important role in making the diagnosis, as several ocular manifestations may be shown during childhood, before tumors of the central nerve system become symptomatic.
  • Neuropathy may lead to vestibular disturbances and loss of muscle control.
  • Therapeutic options include cataract surgery, implantation of cochlear or brainstem implants as well as conservative therapy of the ocular surface in paresis of the VIIth cranial nerve or learning to read from the lips.
  • Geno-phenotype correlations allow some predictions of the course of the disease to be made.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Cranial Nerve Diseases / diagnosis. Cranial Nerve Diseases / genetics. DNA Mutational Analysis. Diagnosis, Differential. Genotype. Humans. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / genetics. Patient Care Team. Phenotype. Referral and Consultation

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  • (PMID = 15844040.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 34
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53. Chen S, Xu Y, Ou Y, Zheng Y, Deng Y, Chen B: [Endoscope-assisted surgical resection of acoustic neuroma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;22(16):729-31
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  • [Title] [Endoscope-assisted surgical resection of acoustic neuroma].
  • OBJECTIVE: To explore the therapeutic efficacy and complications of endoscope-assisted surgical resection of acoustic neuroma.
  • METHOD: Assisted by hard-tube ear endoscope, 11 patients with acoustic neuroma were operated via labyrinthine approach and retrosigmoid approach.
  • CONCLUSION: The application of ear endoscope in acoustic neuroma surgery can improve the total removal rate of tumors and the salvage rate of vessels and nerves.
  • [MeSH-major] Endoscopy. Neuroma, Acoustic / surgery

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  • (PMID = 18975773.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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54. Fortnum H, O'Neill C, Taylor R, Lenthall R, Nikolopoulos T, Lightfoot G, O'Donoghue G, Mason S, Baguley D, Jones H, Mulvaney C: The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history. Health Technol Assess; 2009 Mar;13(18):iii-iv, ix-xi, 1-154
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  • [Title] The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history.
  • OBJECTIVE(S): To evaluate the clinical effectiveness and cost-effectiveness of a range of diagnostic strategies for investigating patients with unilateral hearing loss and/or tinnitus, with a view to confirming or eliminating a diagnosis of acoustic neuroma, and to describe the natural history of acoustic neuroma.
  • ABR has high sensitivity compared with MR imaging for acoustic neuromas greater than 1 cm in size but not for smaller neuromas.
  • Non-contrast-enhanced MR imaging was found to be a more cost-effective test for acoustic neuroma than GdT1W MR imaging.
  • The incidence of acoustic neuroma has increased over the last 30 years, with the median age at diagnosis remaining at 55 years.
  • The pattern and rate of growth of acoustic neuroma are highly variable and currently unpredictable.
  • Given the recent improvement in resolution and reduction in cost of MR imaging, ABR can no longer be considered appropriate as the primary test used to screen for acoustic neuroma.
  • Based on a cost-effectiveness model developed to reflect UK practice it was concluded that a diagnostic algorithm that deploys non-contrast MR imaging as an initial imaging screen in the investigation of acoustic neuroma is less costly than and likely to be as effective as available contrast MR imaging.
  • [MeSH-major] Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / economics
  • [MeSH-minor] Age Distribution. Cost-Benefit Analysis. Evoked Potentials, Auditory, Brain Stem. Hearing Tests. Humans. Incidence. Magnetic Resonance Imaging. Prevalence. Reproducibility of Results. Technology Assessment, Biomedical

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  • (PMID = 19358774.001).
  • [ISSN] 2046-4924
  • [Journal-full-title] Health technology assessment (Winchester, England)
  • [ISO-abbreviation] Health Technol Assess
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 244
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55. Petrovic BD, Futterer SF, Hijaz T, Russell EJ, Karagianis AG: Frequency and diagnostic utility of intralabyrinthine FLAIR hyperintensity in the evaluation of internal auditory canal and inner ear pathology. Acad Radiol; 2010 Aug;17(8):992-1000
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  • RESULTS: Twenty-five of 32 (78%) patients with schwannomas restricted to the IAC and cerebellopontine angle demonstrated associated increased FLAIR signal within the ipsilateral inner ear structures.
  • The sensitivity, specificity, positive predictive value, and negative predictive value of inner ear FLAIR hyperintensity for a schwannoma were 80%, 95%, 78%, and 95%, respectively.
  • Although enhancement after the administration of gadolinium contrast media is the gold standard for detection of schwannoma, inner ear FLAIR hyperintensity may be a helpful diagnostic adjunct for vestibular schwannoma.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ear Neoplasms / pathology. Female. Humans. Male. Middle Aged. Neurilemmoma / pathology. Young Adult

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  • (PMID = 20605731.001).
  • [ISSN] 1878-4046
  • [Journal-full-title] Academic radiology
  • [ISO-abbreviation] Acad Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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56. Dublin A: Acoustic neuroma or vestibular schwannoma? Skull Base; 2009 Sep;19(5):375
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  • [Title] Acoustic neuroma or vestibular schwannoma?

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  • (PMID = 20190950.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765706
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57. Neff BA, Voss SG, Allen C, Schroeder MA, Driscoll CL, Link MJ, Galanis E, Sarkaria JN: Bioluminescent imaging of intracranial vestibular schwannoma xenografts in NOD/SCID mice. Otol Neurotol; 2009 Jan;30(1):105-11
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  • [Title] Bioluminescent imaging of intracranial vestibular schwannoma xenografts in NOD/SCID mice.
  • HYPOTHESIS: Intracranial vestibular schwannoma xenografts can be successfully established and followed with bioluminescent imaging (BLI).
  • BACKGROUND: Transgenic and xenograft mouse models of vestibular schwannomas have been previously reported in the literature.
  • However, none of these models replicate the intracranial location of these tumors to reflect the human disease.
  • Additionally, traditional imaging methods (magnetic resonance imaging, computed tomography) for following tumor engraftment and growth are expensive and time consuming.
  • BLI has been successfully used to longitudinally follow tumor treatment responses in a noninvasive manner.
  • BLI's lower cost and labor demands make this a more feasible approach for tumor monitoring in studies involving large numbers of mice.
  • METHODS: Patient excised vestibular schwannomas were cultured and transduced with firefly luciferase expressing lentivirus.
  • Schwannoma engraftment and growth was prospectively followed for 30 weeks after injection with BLI.
  • After animal sacrifice, the presence of human tumor cells was confirmed with fluorescent in situ hybridization.
  • RESULTS: Eight (38%) of 21 mice successfully engrafted the schwannoma cells.
  • All of these mice were generated from 4 (67%) of the 6 patient excised tumors.
  • Fluorescent in situ hybridization analysis confirmed the presence of viable human schwannoma cells in much greater numbers in those mice with stable or growing tumors compared with those whose tumors regressed.
  • CONCLUSION: We have successfully established an intracranial schwannoma xenograft model that can be followed with noninvasive BLI.
  • We hope to use this model for in vivo testing of schwannoma tumor therapies.
  • [MeSH-major] Neuroma, Acoustic / surgery
  • [MeSH-minor] Animals. Brain / pathology. Brain / surgery. Female. Genes, Neurofibromatosis 2. Humans. In Situ Hybridization, Fluorescence. Lentivirus / isolation & purification. Luminescent Measurements / methods. Magnetic Resonance Imaging. Mice. Mice, Inbred NOD. Mice, Knockout. Mice, SCID. Neoplasm Transplantation. Transplantation, Heterologous

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  • (PMID = 18931645.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA108961; United States / NCI NIH HHS / CA / P50 CA108961-07
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS322037; NLM/ PMC3918230
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58. Javadpour M: Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation? Br J Neurosurg; 2009 Jun;23(3):232-3
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  • [Title] Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation?
  • [MeSH-major] Facial Nerve / surgery. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery

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  • [CommentOn] Br J Neurosurg. 2009 Jun;23(3):226-31 [19533454.001]
  • (PMID = 19533455.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] England
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59. Bartoszewicz R, Niemczyk K, Marchel A, Kowalska M: [Sudden deafness as a presentation of acoustic neuroma]. Pol Merkur Lekarski; 2005 Sep;19(111):307-8
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  • [Title] [Sudden deafness as a presentation of acoustic neuroma].
  • [Transliterated title] Nagła głuchota w symptomatologii guzów nerwu VIII.
  • Acoustic neuroma should always be considered in the differential diagnosis.
  • The authors analysed symptoms occurring in the group of 89 patients, diagnosed with acoustic neuroma.
  • A special attention was paid to the role of sudden deafness as a clinical manifestation of the VIIIth nerve pathology.
  • [MeSH-major] Deafness / etiology. Headache / etiology. Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Tinnitus / etiology


60. Perks JR, El-Hamri K, Blackburn TP, Plowman PN: Comparison of radiosurgery planning modalities for acoustic neuroma with regard to conformity and mean target dose. Stereotact Funct Neurosurg; 2005;83(4):165-71
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  • [Title] Comparison of radiosurgery planning modalities for acoustic neuroma with regard to conformity and mean target dose.
  • MATERIALS AND METHODS: Seven patients with acoustic neuromas deemed clinically suitable for linear accelerator or Gamma Knife radiosurgery were planned such that the minimum doses for any plan were equal.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Radiotherapy Planning, Computer-Assisted

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 16319520.001).
  • [ISSN] 1011-6125
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
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61. Cotton CA, Beall DP, Winter BJ, Fortman BJ, Kirby AB, Ly JQ: Cavernous angioma of the cerebellopontine angle. Curr Probl Diagn Radiol; 2006 May-Jun;35(3):120-3
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  • We describe a case that was initially mistaken for a vestibular schwannoma due to its location in the cerebellopontine angle.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle / pathology. Hemangioma, Cavernous / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 16701123.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Stieglitz LH, Giordano M, Gerganov V, Raabe A, Samii A, Samii M, Lüdemann WO: Petrous bone pneumatization is a risk factor for cerebrospinal fluid fistula following vestibular schwannoma surgery. Neurosurgery; 2010 Dec;67(2 Suppl Operative):509-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Petrous bone pneumatization is a risk factor for cerebrospinal fluid fistula following vestibular schwannoma surgery.
  • OBJECTIVE: To identify the petrous bone air cell volume as a risk factor for developing CSF fistula, we performed a retrospective analysis.
  • METHODS: From 2000 to 2007 519 patients had a retrosigmoidal surgical removal of a vestibular schwannoma.
  • The 22 who had a postoperative CSF fistula were chosen for evaluation in addition to 78 patients who were randomly selected in 4 equally sized cohorts: male/female with small/large tumors.
  • Preoperative CT scans were analyzed regarding petrous bone air cell volume, area of visible pneumatization at the level of the internal auditory canal (IAC), tumor grade, and sex.
  • The mean air cell volume of CSF-fistula patients was 13.72 mL (SD, 5.22).
  • The difference concerning the air cell volume between patients who developed CSF fistulas and patients from the control group was significant (P = .0042).
  • There was a significant positive correlation between the air cell volume and the area of pneumatization in one CT slide at the level of the IAC.
  • A high amount of petrous bone pneumatization has to be considered as a risk factor for the development of postoperative CSF fistula after vestibular schwannoma surgery.
  • [MeSH-major] Cerebrospinal Fluid Rhinorrhea / etiology. Neuroma, Acoustic / surgery. Petrous Bone / abnormalities. Petrous Bone / surgery. Postoperative Complications / etiology


63. House WF, Shelton C: Middle fossa approach for acoustic tumor removal. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):279-88, vi
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  • [Title] Middle fossa approach for acoustic tumor removal. 1992.
  • The middle fossa approach is useful for the removal of small acoustic tumors when hearing preservation is possible.
  • This approach provides complete exposure of the contents of the internal auditory canal and positive facial nerve identification.
  • Because access to the posterior fossa is limited, the middle fossa approach is most appropriate for tumors with less than 5 mm extension into the cerebellopontine angle.
  • With the introduction of gadolinium-enhanced magnetic resonance imaging, very small acoustic tumors are diagonosed more frequently, and the middle fossa approach is well-suited for the removal of these tumors.
  • [MeSH-major] Craniotomy / history. Neuroma, Acoustic / history

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  • (PMID = 18534340.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] House WF; Shelton C
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64. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report. Neurosurgery; 2006 Jul;59(1):E206; discussion E206
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  • [Title] Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report.
  • OBJECTIVE: The majority of tumors of the cerebellopontine angle (CPA) are benign.
  • We report the case of a primary malignant melanoma of the CPA that mimicked a vestibular schwannoma (acoustic neuroma).
  • A neurological work-up revealed a large tumor in the left CPA radiographically diagnosed as a vestibular schwannoma.
  • INTERVENTION: A translabyrinthine approach revealed a pigmented, vascular neoplasm encasing vessels and cranial nerves of the left CPA.
  • The tumor was subtotally resected, and a histopathological diagnosis of melanoma was made.
  • The patient had no history of cutaneous melanoma and no other site of disease was ever discovered.
  • CONCLUSION: This case most likely represents primary melanoma of the central nervous system that mimicked a vestibular schwannoma.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Melanocytes / pathology. Melanoma / diagnosis. Neuroma, Acoustic / diagnosis


65. Maurer J: [The role of brain stem evoked potentials in acoustic neuroma screening and diagnosis]. Laryngorhinootologie; 2008 Aug;87(8):585-96; quiz 597-600
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  • [Title] [The role of brain stem evoked potentials in acoustic neuroma screening and diagnosis].
  • For acoustic tumours > 2 cm the sensitivity of brainstem evoked auditory potentials (BAEP) to detect the retrocochlear lesions is 100 % as for magnetic resonance imaging (MRI).
  • [MeSH-major] Audiometry, Evoked Response. Evoked Potentials, Auditory, Brain Stem / physiology. Neuroma, Acoustic / diagnosis

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  • (PMID = 18654941.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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66. Goodwin L: Acoustic neuroma and radiosurgery. J Insur Med; 2007;39(1):44-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acoustic neuroma and radiosurgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 17500357.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Mathai KI, Sengupta SK, Shashivadhanan, Khanna V, Sudumbrekar SM, Sahoo PK: Hearing Preservation in a Case of Acoustic Schwannoma. Med J Armed Forces India; 2009 Jul;65(3):290-1
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  • [Title] Hearing Preservation in a Case of Acoustic Schwannoma.

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  • (PMID = 27408274.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921402
  • [Keywords] NOTNLM ; Acoustic schwannoma / Hearing conservation
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68. Remenyi J, Marshall A, Enticott JC, Briggs RJ: The prognostic value of speech recognition scores at diagnosis of vestibular schwannoma. J Clin Neurosci; 2009 Nov;16(11):1460-3
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  • [Title] The prognostic value of speech recognition scores at diagnosis of vestibular schwannoma.
  • We aimed to assess whether speech recognition scores (SRS) are predictive of outcomes in patients with small vestibular schwannoma (VS) undergoing observation.
  • [MeSH-major] Memory Disorders / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Pattern Recognition, Physiological / physiology. Speech Perception / physiology
  • [MeSH-minor] Acoustic Stimulation / methods. Adult. Aged. Aged, 80 and over. Audiometry, Pure-Tone / methods. Chi-Square Distribution. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Predictive Value of Tests. Prognosis. Psychoacoustics

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  • (PMID = 19740662.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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69. Lee J, Fung K, Lownie SP, Parnes LS: Assessing impairment and disability of facial paralysis in patients with vestibular schwannoma. Arch Otolaryngol Head Neck Surg; 2007 Jan;133(1):56-60
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  • [Title] Assessing impairment and disability of facial paralysis in patients with vestibular schwannoma.
  • OBJECTIVE: To evaluate facial impairment and disability with respect to quality of life in patients with facial paresis after vestibular schwannoma surgery.
  • PATIENTS: All consecutive patients during a 5-year period who underwent vestibular schwannoma surgery.
  • Subgroup analysis was performed on patient factors (age and sex), surgical factors (tumor size and time since operation), and House-Brackmann grade.
  • Subgroup analysis of patients with facial paresis revealed that age, sex, time since operation, tumor size, and House-Brackmann grade were not statistically significant factors predicting the FaCE social function score (P<.05).
  • CONCLUSIONS: Facial paresis is an important complication of vestibular schwannoma surgery and will impair a patient's quality of life.
  • The level of impairment may not be predicted by a patient's age, sex, tumor size, time since operation, or severity of facial paresis.
  • [MeSH-major] Face / physiology. Facial Paralysis / physiopathology. Neuroma, Acoustic / surgery

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  • (PMID = 17224525.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Kania RE, Herman P, Guichard JP, Tran Ba Huy P: [Dilation of the internal auditory canal and intracanalicular vestibular schwannoma: what are the mechanisms involved?]. Ann Otolaryngol Chir Cervicofac; 2008 Nov;125(5):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Dilation of the internal auditory canal and intracanalicular vestibular schwannoma: what are the mechanisms involved?].
  • [Transliterated title] Dilatation du méat acoustique interne et schwannome vestibulaire intracanalaire: quels mécanismes?
  • OBJECTIVES: To present a unique case of unilateral widening of the internal auditory canal (IAC) with no significant contact with an ipsilateral intracanalicular vestibular schwannoma (VS), raising the issue of the cause(s) of this IAC widening.
  • [MeSH-major] Ear Diseases / etiology. Ear, Inner / pathology. Neuroma, Acoustic / complications

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  • (PMID = 18786666.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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71. Franco-Vidal V, Blanchet H, Liguoro D, Darrouzet V: [Side-to-end hypoglossal-facial nerve anastomosis with intratemporal facial nerve translocation. Long-term results and indications in 15 cases over 10 years]. Rev Laryngol Otol Rhinol (Bord); 2006;127(1-2):97-102
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  • [Title] [Side-to-end hypoglossal-facial nerve anastomosis with intratemporal facial nerve translocation. Long-term results and indications in 15 cases over 10 years].
  • [Transliterated title] L'anastomose hypoglosso-faciale latéro-terminale avec déroutement du nerf facial intrapétreux. Résultats à long terme et indications. Une expérience de 10 ans sur 15 cas.
  • OBJECTIVES: To describe functional results concerning facial and lingual mobility after side-to end hypoglossal facial nerve anastomosis.
  • MATERIAL AND METHODS: 15 patients were operated on between 1993 and 2002 (11 cases of facial nerve injury during vestibular schwannoma surgery, and 4 cases of brainstem stroke).
  • The less satisfactory results were observed when patients were managed late (>2 years after nerve section) and in case of brainstem stroke.
  • [MeSH-major] Facial Nerve / surgery. Facial Paralysis / surgery. Hypoglossal Nerve / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 16886539.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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72. Furuta S, Takahashi S, Higano S, Hashimoto S: Prediction of the origin of intracanalicular neoplasms with high-resolution MR imaging. Neuroradiology; 2005 Sep;47(9):657-63
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  • For MR diagnosis, the origin of intracanalicular neoplasms was predicted according to the location of the tumor in the internal auditory canal (IAC) in two ways, i.e., determining (1) a single specific nerve of origin and (2) whether the tumor originated from the superior or inferior aspect of the IAC.
  • Surgery could determine the nerve of origin in 16 cases (14 inferior and 2 superior vestibular schwannomas), but it was indeterminate in 4.
  • Comparison between MR prediction and surgical results on a single nerve origin revealed exact agreement in five, but inconsistent in three.
  • Regarding whether the tumor was derived from superior or inferior aspect of the IAC, agreement was found in 10 of the 16 cases (62.5%).
  • Caloric test was abnormal in all patients examined but one with superior vestibular schwannoma.
  • 3DFT-MR imaging was not particularly useful in predicting a precise nerve of origin of intracanalicular neoplasms.
  • The prediction on whether the tumor originated in the superior or inferior aspect of the IAC was superior to caloric test, which might have clinical significance in treatment planning especially for hearing preservation surgery.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Ear, Inner / pathology. Facial Nerve Diseases / pathology. Vestibulocochlear Nerve Diseases / pathology

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  • (PMID = 16172909.001).
  • [ISSN] 0028-3940
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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73. Myrseth E, Pedersen PH, Møller P, Lund-Johansen M: Treatment of vestibular schwannomas. Why, when and how? Acta Neurochir (Wien); 2007;149(7):647-60; discussion 660
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  • [Title] Treatment of vestibular schwannomas. Why, when and how?
  • Sporadic vestibular schwannoma (VS) causes unilateral hearing loss, tinnitus, vertigo and unsteadiness.
  • The predominant clinical endpoints of VS treatment include tumour control, facial nerve function and hearing preservation.
  • [MeSH-major] Neuroma, Acoustic / surgery. Neurosurgical Procedures / standards. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Radiosurgery / standards. Vestibular Nerve / surgery
  • [MeSH-minor] Facial Nerve Injuries / prevention & control. Humans. Quality of Life. Risk Assessment. Vestibulocochlear Nerve Diseases / prevention & control

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  • (PMID = 17558460.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 144
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74. Zwick OM, Seiff SR: Supportive care of facial nerve palsy with temporary external eyelid weights. Optometry; 2006 Jul;77(7):340-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Supportive care of facial nerve palsy with temporary external eyelid weights.
  • BACKGROUND: Patients with facial nerve palsy can have many ocular complications.
  • Lagophthalmos, or poor eyelid closure, and loss of blink secondary to lack of nerve supply to the orbicularis oculi, can lead to exposure keratopathy, corneal breakdown, ulcers, and even perforation.
  • Patients with facial nerve palsy who present at earlier stages can benefit from conservative treatment.
  • CASE REPORT: A 29-year-old patient with lagophthalmos secondary to left facial nerve palsy after surgical excision of an acoustic neuroma was treated with a temporary external eyelid weight.
  • CONCLUSION: Temporary external eyelid weights are part of the armamentarium in the supportive care of patients with lagophthalmos and exposure keratopathy secondary to facial nerve palsy.

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  • (PMID = 16814237.001).
  • [ISSN] 1529-1839
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Gharabaghi A, Samii A, Koerbel A, Rosahl SK, Tatagiba M, Samii M: Preservation of function in vestibular schwannoma surgery. Neurosurgery; 2007 Feb;60(2 Suppl 1):ONS124-7; discussion ONS127-8
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  • [Title] Preservation of function in vestibular schwannoma surgery.
  • The management and surgical technique for microsurgical tumor removal of vestibular schwannomas (acoustic neuroma) with the suboccipital retrosigmoid approach and semi-sitting patient positioning is described.
  • An emphasis is placed on the preservation of auditory and facial nerve function with a stepwise description of the technical and operative nuances, including presurgical evaluation, positioning, anesthesiological and neurophysiological aspects, approach, microsurgical techniques, and postsurgical care.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Otologic Surgical Procedures / methods

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  • (PMID = 17297374.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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76. Richter S, Schoch B, Ozimek A, Gorissen B, Hein-Kropp C, Kaiser O, Hövel M, Wieland R, Gizewski E, Ziegler W, Timmann D: Incidence of dysarthria in children with cerebellar tumors: a prospective study. Brain Lang; 2005 Feb;92(2):153-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence of dysarthria in children with cerebellar tumors: a prospective study.
  • The present study investigated dysarthric symptoms in children with cerebellar tumors.
  • Ten children with cerebellar tumors and 10 orthopedic control children were tested prior and one week after surgery.
  • Localization of the cerebellar lesions were defined after manual transfer from individual 2D-MR images onto 3D images of a spatially normalized healthy brain.
  • In children, speech impairments appear to be rare after cerebellar surgery because tumors most commonly affect posterior-inferior and medial parts of the cerebellum while critical cerebellar regions are likely spared.
  • [MeSH-minor] Acoustic Stimulation. Adolescent. Child. Female. Humans. Incidence. Magnetic Resonance Imaging. Male. Medulloblastoma / epidemiology. Medulloblastoma / pathology. Medulloblastoma / surgery. Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Prospective Studies. Speech. Speech Perception

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  • (PMID = 15629489.001).
  • [ISSN] 0093-934X
  • [Journal-full-title] Brain and language
  • [ISO-abbreviation] Brain Lang
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Mrugala MM, Batchelor TT, Plotkin SR: Peripheral and cranial nerve sheath tumors. Curr Opin Neurol; 2005 Oct;18(5):604-10
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  • [Title] Peripheral and cranial nerve sheath tumors.
  • PURPOSE OF REVIEW: The intention of the authors is to provide the reader with an overview of the recent advances in the diagnosis and treatment of nerve sheath tumors.
  • Vestibular schwannomas, neurogenetic syndromes such as schwannomatosis and multiple isolated neurofibromas, and malignant peripheral nerve sheath tumors are covered in this review.
  • RECENT FINDINGS: Over the last year, literature focusing on different management strategies for patients with vestibular schwannomas dominated the field.
  • New insights into the biology of peripheral nerve tumor development and growth, including expression of vascular endothelial growth factor by vestibular schwannomas and the role of Notch signaling in malignant transformation of benign neurofibromas have been described.
  • SUMMARY: Peripheral nerve tumors are classified according to the specific features of cellular differentiation.
  • The most common types include schwannoma and neurofibroma.
  • These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis.
  • The majority of peripheral nerve tumors are benign but malignant transformation does occur.
  • Metastatic tumors can also affect peripheral nerves.
  • Positron emission tomography is a useful technique in the presurgical differentiation between benign and malignant peripheral nerve sheath tumors.
  • [MeSH-major] Cranial Nerve Neoplasms. Nerve Sheath Neoplasms / diagnosis. Nerve Sheath Neoplasms / therapy. Peripheral Nervous System Neoplasms

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  • (PMID = 16155448.001).
  • [ISSN] 1350-7540
  • [Journal-full-title] Current opinion in neurology
  • [ISO-abbreviation] Curr. Opin. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 33
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78. Arts HA, Telian SA, El-Kashlan H, Thompson BG: Hearing preservation and facial nerve outcomes in vestibular schwannoma surgery: results using the middle cranial fossa approach. Otol Neurotol; 2006 Feb;27(2):234-41
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  • [Title] Hearing preservation and facial nerve outcomes in vestibular schwannoma surgery: results using the middle cranial fossa approach.
  • OBJECTIVE: To evaluate surgical results using the middle cranial fossa approach for hearing preservation vestibular schwannoma surgery.
  • PATIENTS: Seventy-three consecutive patients with vestibular schwannoma operated on using the middle cranial fossa approach between February 1999 and February 2005.
  • INTERVENTIONS: The tumors were removed via the middle cranial fossa approach with modifications to improve exposure.
  • Standard auditory brainstem and facial nerve monitoring were used.
  • MAIN OUTCOME MEASURES: Pre- and postoperative hearing measures and facial function, tumor size, and postoperative complications.
  • Hearing status was categorized into Classes A, B, C, and D as described by the American Academy of Otolaryngology-Head and Heck Surgery "Guidelines for the Evaluation of Hearing Preservation in Acoustic Neuroma, 1995."
  • Nineteen patients had tumors larger than 10 mm in greatest dimension and had Class A or B hearing preoperatively.
  • At 4 months or greater follow-up, facial nerve outcome were excellent in 96%: House-Brackmann Grade I in 61 (85%), Grade II in 8 (11%), and Grade III in 3 (4%).
  • CONCLUSION: By achieving excellent exposure and using meticulous microsurgical technique, it is possible to resect small vestibular schwannomas via the middle fossa approach, with preservation of hearing at excellent or preoperative levels in the majority of patients, with excellent or satisfactory facial nerve outcomes in 96% of patients.
  • [MeSH-major] Auditory Threshold / physiology. Facial Nerve / physiology. Facial Paralysis / prevention & control. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16436995.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Lustgarten L: Use of Bioglue in translabyrinthine vestibular schwannoma surgery. Otol Neurotol; 2007 Oct;28(7):992
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  • [Title] Use of Bioglue in translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Bone Cements. Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures. Vestibulocochlear Nerve Diseases / surgery

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  • [CommentOn] Otol Neurotol. 2006 Jan;27(1):102-5 [16371855.001]
  • (PMID = 17909439.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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80. Jatana KR, Jacob A, Slone HW, Ray-Chaudhury A, Welling DB: Spinal myxopapillary ependymoma metastatic to bilateral internal auditory canals. Ann Otol Rhinol Laryngol; 2008 Feb;117(2):98-102
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  • The diagnosis of NF2 with bilateral vestibular schwannomas was entertained.
  • This finding raised the possibility of other, more unusual IAC lesions.
  • Although vestibular schwannomas account for the majority of contrast-enhancing T1-weighted IAC lesions, other uncommon lesions may present in a similar manner.
  • Therefore, both T1-weighted MRI with or without contrast and T2-weighted MRI may be necessary to distinguish vestibular schwannoma from other, more unusual IAC lesions.

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  • (PMID = 18357830.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Pitchford CW, Schwartz HS, Atkinson JB, Cates JM: Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. Am J Surg Pathol; 2006 Dec;30(12):1624-9
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  • [Title] Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome.
  • Neoplasms that commonly affect patients with neurofibromatosis type 2 (NF2) include schwannomas, meningiomas, astrocytomas, ependymomas, and neurofibromas.
  • Perineuriomas are rare tumors of the peripheral nerve sheath that share some characteristics with meningioma.
  • As in both NF2-associated and sporadic cases of schwannoma and meningioma, perineuriomas often harbor mutations or deletions of the NF2 gene.
  • A 30-year-old man with a history of bilateral vestibular schwannomas, a parasagittal meningioma, an intraspinal ependymoma, and multiple other neoplasms involving both cranial and peripheral nerves (thereby fulfilling the diagnostic criteria for NF2) presented with an enlarging thigh mass.
  • [MeSH-major] Nerve Sheath Neoplasms / complications. Neurofibromatosis 2 / complications. Soft Tissue Neoplasms / complications
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Cytoplasm / ultrastructure. Diagnosis, Differential. Humans. Male. Neoplasms, Multiple Primary. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 17122521.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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82. Baser ME, Contributors to the International NF2 Mutation Database: The distribution of constitutional and somatic mutations in the neurofibromatosis 2 gene. Hum Mutat; 2006 Apr;27(4):297-306
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  • Constitutional heterozygous inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene cause the autosomal dominant disease NF2, and biallelic inactivating somatic NF2 mutations are found in a high proportion of unilateral sporadic vestibular schwannoma (USVS) and sporadic meningioma.


83. Anastasian ZH, Ornstein E, Heyer EJ: Delayed arousal. Anesthesiol Clin; 2009 Sep;27(3):429-50, table of contents
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  • [Title] Delayed arousal.
  • Elderly patients have medical and psychological problems affecting all major organ systems.
  • These problems may alter the pharmacokinetics and/or pharmacodynamics of medications, or expose previous neurologic deficits simply as a result of sedation.
  • Delayed arousal, therefore, may arise from structural problems that are pre-existent or new, or metabolic or functional disorders such as convulsive or nonconvulsive seizures.
  • Determining the cause of delayed arousal may require clinical, chemical, and structural tests.
  • Structural problems that impair consciousness arise from a small number of focal lesions to specific areas of the central nervous system, or from pathology affecting the cerebrum.
  • In general, focal or multifocal lesions can be identified by computerized tomography, or diffusion-weighted imaging.
  • An algorithm is presented that outlines a workup for an elderly patient with delayed arousal.

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  • (PMID = 19825485.001).
  • [ISSN] 1932-2275
  • [Journal-full-title] Anesthesiology clinics
  • [ISO-abbreviation] Anesthesiol Clin
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / AG017604-05A2; United States / NIA NIH HHS / AG / R01 AG017604; United States / NIA NIH HHS / AG / R01 AG017604-05A2; United States / NIA NIH HHS / AG / R01-AG16404
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 91
  • [Other-IDs] NLM/ NIHMS158134; NLM/ PMC3036001
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84. Saman Y, Bamiou DE, Gleeson M: A contemporary review of balance dysfunction following vestibular schwannoma surgery. Laryngoscope; 2009 Nov;119(11):2085-93
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  • [Title] A contemporary review of balance dysfunction following vestibular schwannoma surgery.
  • OBJECTIVES/HYPOTHESIS: This review aims to evaluate the literature pertaining to subjective balance dysfunction following vestibular schwannoma surgery; the effect of postoperative imbalance on disability, handicap and quality of life; and to determine factors that influence vestibular compensation.
  • METHODS: Ovid MEDLINE, Cochrane databases, and relevant contemporary texts were searched for papers relating to subjective balance dysfunction following vestibular schwannoma surgery.
  • RESULTS: The search yielded 26 studies assessing subjective balance dysfunction following vestibular schwannoma surgery.
  • CONCLUSIONS: Further study is needed of the factors that influence vestibular compensation following vestibular schwannoma surgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications. Postural Balance. Sensation Disorders

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  • (PMID = 19806649.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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85. Bush ML, Jones RO, Shinn JB: Auditory brainstem response threshold differences in patients with vestibular schwannoma: a new diagnostic index. Ear Nose Throat J; 2008 Aug;87(8):458-62
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  • [Title] Auditory brainstem response threshold differences in patients with vestibular schwannoma: a new diagnostic index.
  • Auditory brainstem response (ABR) testing is less sensitive in detecting small vestibular schwannomas than medium-size tumors.
  • Magnetic resonance imaging (MRI) is more sensitive than ABR alone for small and large tumors, but it carries with it increased cost and issues of unavailability and patient discomfort.
  • We conducted a prospective pilot study of 7 patients with untreated MRI-proven, unilateral vestibular schwannoma to determine if we could increase the sensitivity of ABR testing in detecting small tumors.
  • [MeSH-major] Brain Stem / pathology. Evoked Potentials, Auditory, Brain Stem. Neuroma, Acoustic / diagnosis

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  • (PMID = 18712694.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Timmer FC, van Haren AE, Mulder JJ, Hanssens PE, van Overbeeke JJ, Cremers CW, Graamans K: Quality of life after gamma knife radiosurgery treatment in patients with a vestibular schwannoma: the patient's perspective. Eur Arch Otorhinolaryngol; 2010 Jun;267(6):867-73
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  • [Title] Quality of life after gamma knife radiosurgery treatment in patients with a vestibular schwannoma: the patient's perspective.
  • This study evaluates the impact of gamma knife radiosurgery (GKRS) on the quality of life (QOL) of patients with a sporadic vestibular schwannoma (VS).
  • Their mean tumor size was 17 mm (range 6-39 mm); the mean maximum dose on the tumor was 19.9 Gy (range 16-25.5 Gy) and the mean marginal dose on the tumor was 11.1 (range 9.3-12.5 Gy).
  • No correlation was found between QOL and gender, age, tumor size, or radiation dose.
  • No predictive patient, tumor, or treatment factors for QOL outcome after GKRS could be determined.
  • [MeSH-major] Neuroma, Acoustic / psychology. Neuroma, Acoustic / surgery. Patient Satisfaction. Quality of Life / psychology. Radiosurgery / psychology

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  • (PMID = 19894058.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2857884
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87. Ahmad M, Butt RM, Ahmad N: Jugular foramen schwannoma--a very rare entity. J Ayub Med Coll Abbottabad; 2009 Apr-Jun;21(2):174-5
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  • [Title] Jugular foramen schwannoma--a very rare entity.
  • Jugular foramen schwannoma is a very rare tumour and very few cases have been reported in the literature.
  • Usually it is misdiagnosed as acoustic neuroma and the diagnosis is made peroperatively.
  • We present a case of jugular foramen schwannoma who was operated by the senior author.
  • [MeSH-major] Glomus Jugulare Tumor / surgery. Head and Neck Neoplasms / surgery. Jugular Veins. Neurilemmoma / surgery. Vascular Neoplasms / surgery

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  • (PMID = 20524500.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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88. Somefun OA, Giwa OS, Bamgboye BA, Okeke-Igbokwe II, Azeez AA: Vestibular disorders among adults in a tertiary hospital in Lagos, Nigeria. Eur Arch Otorhinolaryngol; 2010 Oct;267(10):1515-21
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  • [Title] Vestibular disorders among adults in a tertiary hospital in Lagos, Nigeria.
  • The objective of this study was to document the evaluation, causes and treatment of vestibular disorders among our patients.
  • X-ray of the cervical spine and computerized tomogram scan of internal auditory meatus and brain when indicated were done.
  • Clinical signs on neuro-otological examination were elicited on 39 (38.2%) of the patients while on VNG the vestibular subtest mainly caloric test was abnormal unilaterally and bilaterally in 47 (46.1%) while with the oculomotor subtests, smooth pursuit tests were abnormal in 5 (6.9%), saccade tests were abnormal in 8 (7.8%) and OPK were abnormal in 9 (8.8%).
  • Peripheral vestibular disorders are common of which benign paroxysmal positional vertigo (BPPV) was seen in 29 (28.4%), Meniere's disease in 22 (21.6%), recurrent vestibulopathy in 20 (19.6%), cervical vertigo in 18 (17.6%), psychogenic vertigo in 2 (2%), vestibular schwannoma, barotraumas and drug-induced vertigo in 1 (1%), respectively, central vestibular disorders of vascular origin 2 (2%), vertebrobasilar insufficiency in 1 (1%), post-traumatic vertigo in 3 (3%) and unknown in 2 (2%).
  • In conclusion, peripheral vestibular disorders are common of which BPPV is the most prevalent.
  • [MeSH-major] Vestibular Diseases / diagnosis. Vestibular Diseases / epidemiology

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  • (PMID = 20464409.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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89. Beegle RD, Friedman WA, Bova FJ: Effect of treatment plan quality on outcomes after radiosurgery for vestibular schwannoma. J Neurosurg; 2007 Nov;107(5):913-6
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  • [Title] Effect of treatment plan quality on outcomes after radiosurgery for vestibular schwannoma.
  • OBJECT: The goal in this study was to review the effects of treatment plan quality on outcomes after radiosurgery for vestibular schwannoma (VS).
  • Multivariate statistics were used to determine the effects of these variables on tumor control and on two types of complication, facial weakness and facial numbness.
  • RESULTS: The 5-year actuarial tumor control was 91%.
  • Dosimetry had no effect on tumor control.
  • In this model, prior tumor growth was also significant.
  • [MeSH-major] Neuroma, Acoustic / surgery. Patient Care Planning / standards. Radiosurgery / methods
  • [MeSH-minor] Facial Nerve Diseases / etiology. Humans. Postoperative Complications. Radiometry

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  • (PMID = 17977260.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Kitahara T, Maekawa C, Kizawa K, Horii A, Doi K: Plasma vasopressin and V2 receptor in the endolymphatic sac in patients with delayed endolymphatic hydrops. Otol Neurotol; 2009 Sep;30(6):812-9
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  • Delayed endolymphatic hydrops (DEH) is an inner ear disease like Ménière's disease (MD) characterized by episodic vertigo in the setting of preexisting unilateral deafness that especially occurs in civilized people with a stressful lifestyle.
  • Its otopathologic finding was demonstrated to be inner ear endolymphatic hydrops through a temporal bone study in 1976, as in the case with MD in 1938.
  • Using the real-time polymerase chain reaction method with tissue samples obtained during surgery, we examined V2R mRNA expression in the endolymphatic sac in 6 patients with ipsilateral DEH, 9 patients with unilateral MD, and 6 control patients with acoustic neuroma.
  • RESULTS: Plasma vasopressin (1.5 times versus controls; unpaired t test, p = 0.140) and V2R mRNA expression in the endolymphatic sac (35.8 times versus controls; unpaired t test, p = 0.002) were higher in patients with DEH compared with those with acoustic neuroma.
  • [MeSH-minor] Adult. Blotting, Western. Data Interpretation, Statistical. Female. Humans. Male. Meniere Disease / complications. Middle Aged. Otologic Surgical Procedures. Prospective Studies. RNA / biosynthesis. RNA / genetics. Reverse Transcriptase Polymerase Chain Reaction. Vertigo / etiology

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  • (PMID = 19638944.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Vasopressin; 11000-17-2 / Vasopressins; 63231-63-0 / RNA
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91. Kramer F, Stöver T, Warnecke A, Diensthuber M, Lenarz T, Wissel K: BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. J Neurooncol; 2010 May;98(1):31-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity.
  • The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves.
  • Vestibular schwannoma arising from Schwann cells of the vestibular nerve are mostly benign and slow-growing.
  • Most of the pathogenic mechanisms regulating the vestibular schwannoma growth process are unknown.
  • However, molecular mechanisms interfering with regulation of the vestibular schwannoma growth also modulated by mitogenic factors have to be identified.
  • Neurotrophic factors are involved in regulation of developmental processes in neuronal tissues and regeneration after peripheral nerve trauma and also reveal mitogenic effects on glial cell populations.
  • Gene expression profiles of artemin, BDNF, GDNF, TGF-beta1/beta2 and Ret were determined in the vestibular schwannoma in comparison to the peripheral nerve tissues by using semiquantitative RT-PCR.
  • A significant higher BDNF expression was observed in the vestibular schwannoma, whereas gene expression of artemin and GDNF was upregulated in peripheral nerves.
  • The correlation between LI and BDNF, TGF-beta1 and Ret was found to be significant in the vestibular schwannoma.
  • Our results demonstrate a coherence between BDNF expression and proliferative activity in the vestibular schwannoma.
  • Based on these results, we propose a pivotal role for BDNF in modulating the vestibular schwannoma growth.
  • [MeSH-major] Brain-Derived Neurotrophic Factor / genetics. Cell Proliferation. Gene Expression Regulation, Neoplastic / physiology. Neuroma, Acoustic / genetics. RNA, Messenger / metabolism. Up-Regulation / physiology
  • [MeSH-minor] Adult. Aged. Female. Glial Cell Line-Derived Neurotrophic Factor / genetics. Glial Cell Line-Derived Neurotrophic Factor / metabolism. Humans. Ki-67 Antigen / metabolism. Male. Middle Aged. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Peripheral Nerves / metabolism. Statistics as Topic / methods. Statistics, Nonparametric. Transforming Growth Factor beta1 / genetics. Transforming Growth Factor beta1 / metabolism. Transforming Growth Factor beta2 / genetics. Transforming Growth Factor beta2 / metabolism. Young Adult

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  • (PMID = 19937367.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARTN protein, human; 0 / Brain-Derived Neurotrophic Factor; 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Ki-67 Antigen; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1; 0 / Transforming Growth Factor beta2
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92. Liu JK, Sayama CM, Shelton C, MacDonald JD: Transient facial nerve palsy after topical papaverine application during vestibular schwannoma surgery. Case report. J Neurosurg; 2007 Nov;107(5):1039-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient facial nerve palsy after topical papaverine application during vestibular schwannoma surgery. Case report.
  • Some evidence in the literature supports the topical application of papaverine to the cochlear nerve to prevent internal auditory artery vasospasm and cochlear ischemia as a method of enhancing the ability to preserve hearing during acoustic neuroma surgery.
  • The authors report a case of transient facial nerve palsy that occurred after papaverine was topically applied during a hearing preservation acoustic neuroma removal.
  • Magnetic resonance imaging demonstrated a 1.5-cm acoustic neuroma in the right cerebellopontine angle (CPA).
  • A retrosigmoid approach was performed to achieve gross-total resection of the tumor.
  • During tumor removal, a solution of 3% papaverine soaked in a Gelfoam pledget was placed over the cochlear nerve.
  • Shortly thereafter, the quality of the facial nerve stimulation deteriorated markedly.
  • Electrical stimulation of the facial nerve did not elicit a response at the level of the brainstem but was observed to elicit a robust response more peripherally.
  • At the 1-month follow-up examination, the patient exhibited normal facial nerve function and stable hearing.
  • Intracisternal papaverine may cause a transient facial nerve palsy by producing a temporary conduction block of the facial nerve.
  • [MeSH-major] Facial Paralysis / chemically induced. Neuroma, Acoustic / surgery. Papaverine / adverse effects. Vasodilator Agents / adverse effects

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  • (PMID = 17977279.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vasodilator Agents; DAA13NKG2Q / Papaverine
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93. Tong MC, Lam JM, Hu BH, Sanna M: [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Sep;40(9):705-7
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  • [Title] [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas].
  • [MeSH-major] Fenestration, Labyrinth / methods. Neuroma, Acoustic / surgery

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  • (PMID = 16335411.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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94. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102 Suppl:111-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> 3 cm in diameter).
  • Facial and cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.
  • [MeSH-major] Facial Nerve / physiology. Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cochlear Nerve / physiopathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Microsurgery / instrumentation. Middle Aged. Neoplasm Recurrence, Local. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / surgery. Radiation Dosage. Time Factors

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  • (PMID = 15662791.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Kambe A, Kamitani H, Watanabe T, Oka A, Inagaki H, Ishii T, Ueki K: A non-NF2 case of schwannomas of vestibular and trigeminal nerves with different genetic alterations of NF2 gene: case report. Surg Neurol; 2005 Jan;63(1):62-4; discussion 64-5
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  • [Title] A non-NF2 case of schwannomas of vestibular and trigeminal nerves with different genetic alterations of NF2 gene: case report.
  • BACKGROUND: We report a patient with 2 separate schwannomas, a vestibular schwannoma and a trigeminal schwannoma, that were attached to each other and appeared to be a single tumor on imaging studies.
  • CASE DESCRIPTION: The patient, without any family history of neurofibromatosis, presented with a progressive hearing loss and mild left facial nerve palsy.
  • Magnetic resonance imaging showed a snowman-like tumor in the left cerebellopontine angle.
  • Surgical exposure revealed that the tumor consisted of 2 "kissing" schwannomas, a trigeminal and vestibular schwannoma.
  • Molecular genetic analysis detected a 1-base pair deletion at exon 10 of the neurofibromatosis type 2 (NF2) gene in the trigeminal schwannoma, but not in the acoustic schwannoma.
  • However, loss of heterozygosity at chromosome 22q (D22S282 and D22S929) was detected in both tumors, losing the same allele.
  • CONCLUSION: Multiple schwannomas in non-NF2 patients are extremely rare, and possible causes include simple coincidence or germline genetic alteration of adjacent gene on chromosome 22q, similar to the cause recently suggested in familial schwannomatosis.
  • [MeSH-major] Genes, Neurofibromatosis 2. Neuroma, Acoustic / genetics. Trigeminal Nerve / pathology. Trigeminal Nerve Diseases / genetics. Vestibular Nerve / pathology
  • [MeSH-minor] Chromosomes, Human, Pair 22 / genetics. Craniotomy. DNA Mutational Analysis. Decompression, Surgical. Facial Nerve Diseases / etiology. Facial Nerve Diseases / pathology. Facial Nerve Diseases / physiopathology. Gene Deletion. Hearing Loss / etiology. Hearing Loss / pathology. Hearing Loss / physiopathology. Humans. Loss of Heterozygosity / genetics. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome

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  • (PMID = 15639530.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Raftopoulos C, Abu Serieh B, Duprez T, Docquier MA, Guérit JM: Microsurgical results with large vestibular schwannomas with preservation of facial and cochlear nerve function as the primary aim. Acta Neurochir (Wien); 2005 Jul;147(7):697-706; discussion 706
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgical results with large vestibular schwannomas with preservation of facial and cochlear nerve function as the primary aim.
  • OBJECTIVE: To evaluate our microsurgical results in dealing with vestibular schwannomas (VS) greater than or equal to 30 mm when preservation of cranial nerve function was considered more important than total tumour removal.
  • METHODS: Sixteen consecutive cases were operated on by the same neurosurgeon according to a prospective protocol using intraoperative neuro-monitoring (IONM) based on electromyographic and brain stem auditory evoked potential recordings.
  • Facial nerve function was evaluated on the House-Brackmann Scale and cochlear nerve function on the Gardner-Robertson Scale.
  • RESULTS: Fifteen patients showed facial nerve (FN) function of House-Brackmann grade (HBG) I or II at one year postoperatively and one kept the HBG IV she had preoperatively.
  • Two patients of four maintained a cochlear nerve function of Gardner-Robertson grade (GRG) II.
  • CONCLUSION: When dealing with VS greater than or equal to 30 mm, microsurgery guided by IONM, with a rate of total or near-total tumour excision of about 75%, can retain socially acceptable facial nerve function (HBG I or II) in all cases and serviceable hearing (GRG I or II) in two cases out of four.
  • Maintaining serviceable cranial nerve function should take precedence over total tumour excision.
  • [MeSH-major] Electromyography. Evoked Potentials, Auditory, Brain Stem / physiology. Microsurgery. Monitoring, Intraoperative. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology
  • [MeSH-minor] Adult. Aged. Brain Stem / physiopathology. Child. Cochlear Nerve / physiopathology. Facial Nerve / physiopathology. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Male. Middle Aged. Neurologic Examination. Prospective Studies

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  • (PMID = 15900399.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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97. Francesco F, Maurizio I, Stefano C, Marina S, Ugo S, Massimo S: Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor. J Neurooncol; 2010 Apr;97(2):285-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trigeminal nerve root entry zone pilocytic astrocytoma in an adult: a rare case of an extraparenchymal tumor.
  • Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults.
  • Vestibular schwannomas are the most common, followed by meningiomas.
  • Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors.
  • We describe a pilocytic astrocytoma of the CPA that was found to arise from the proximal portion of trigeminal nerve without any anatomic continuity with the brain stem and the cerebellum.
  • Pre-operative MRI suggested a schwannoma.
  • The proposed origin of this extremely rare tumor is the root entry zone of the involved nerve.
  • The tumor was completely resected via a suboccipital retrosigmoid approach.
  • [MeSH-major] Astrocytoma / pathology. Cerebellar Neoplasms / pathology. Cerebellopontine Angle / pathology. Cranial Nerve Neoplasms / pathology. Trigeminal Nerve Diseases / pathology

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  • [Cites] Arch Otolaryngol. 1980 Aug;106(8):456-9 [7396789.001]
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  • (PMID = 19820900.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Evans DG, Ramsden RT, Shenton A, Gokhale C, Bowers NL, Huson SM, Pichert G, Wallace A: Mosaicism in neurofibromatosis type 2: an update of risk based on uni/bilaterality of vestibular schwannoma at presentation and sensitive mutation analysis including multiple ligation-dependent probe amplification. J Med Genet; 2007 Jul;44(7):424-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mosaicism in neurofibromatosis type 2: an update of risk based on uni/bilaterality of vestibular schwannoma at presentation and sensitive mutation analysis including multiple ligation-dependent probe amplification.
  • RESULTS: 64 mosaic patients, with a projected mosaicism rate of 33% for sporadic classical NF2 with bilateral vestibular schwannoma at presentation and 60% for those presenting unilaterally, were identified.
  • [MeSH-major] Genetic Predisposition to Disease. Mosaicism. Neurofibromatosis 2 / complications. Neurofibromatosis 2 / genetics. Neuroma, Acoustic / etiology


99. Halefoğlu AM: Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report. Kulak Burun Bogaz Ihtis Derg; 2007;17(3):171-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurofibromatosis type 2 associated with multiple cranial nerve schwannomas: a case report.
  • He also had a family history of neurofibromatosis type 2 and a history of a prior operation for left vestibular schwannoma a year ago.
  • Magnetic resonance imaging demonstrated multiple extra-axial enhancing masses in the vicinity of both hypoglossal nerves, the right vestibular nerve, the left vestibular nerve, the right trigeminal, the left occulomotor, and the right abducens nerves.
  • These findings were evaluated as multiple cranial nerve schwannomas.
  • [MeSH-major] Cochlear Nerve. Cranial Nerve Neoplasms / diagnosis. Neurilemmoma / diagnosis. Neurofibromatosis 2 / diagnosis

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  • (PMID = 17873509.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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100. Akhmametyeva EM, Mihaylova MM, Luo H, Kharzai S, Welling DB, Chang LS: Regulation of the neurofibromatosis 2 gene promoter expression during embryonic development. Dev Dyn; 2006 Oct;235(10):2771-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mutations in the Neurofibromatosis 2 (NF2) gene are associated with predisposition to vestibular schwannomas, spinal schwannomas, meningiomas, and ependymomas.
  • Importantly, we observed strong NF2 promoter activity in the developing brain and in sites containing migrating cells including the neural tube closure, branchial arches, dorsal aorta, and paraaortic splanchnopleura.
  • Furthermore, we noted a transient change of NF2 promoter activity during neural crest cell migration.
  • In addition, we detected considerable NF2 promoter activity in various NF2-affected tissues such as acoustic ganglion, trigeminal ganglion, spinal ganglia, optic chiasma, the ependymal cell-containing tela choroidea, and the pigmented epithelium of the retina.
  • The NF2 promoter expression pattern during embryogenesis suggests a specific regulation of the NF2 gene during neural crest cell migration and further supports the role of merlin in cell adhesion, motility, and proliferation during development.
  • [MeSH-minor] Animals. Cell Movement / genetics. Cell Movement / physiology. DNA, Complementary / genetics. Ectoderm / metabolism. Female. Ganglia / embryology. Ganglia / metabolism. Humans. Immunohistochemistry. In Situ Hybridization / methods. Male. Mice. Mice, Transgenic. Nervous System / embryology. Nervous System / metabolism. Neural Crest / embryology. Neural Crest / metabolism. Pregnancy. Recombinant Fusion Proteins / genetics. Recombinant Fusion Proteins / metabolism. beta-Galactosidase / genetics. beta-Galactosidase / metabolism

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16894610.001).
  • [ISSN] 1058-8388
  • [Journal-full-title] Developmental dynamics : an official publication of the American Association of Anatomists
  • [ISO-abbreviation] Dev. Dyn.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16058
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Neurofibromin 2; 0 / Recombinant Fusion Proteins; EC 3.2.1.23 / beta-Galactosidase
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