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1. Cho EY, Kim TH, Park SD, Yun KJ, Choi SC, Kim HC, Nah YH: Acral metastasis in a patient with ampullary carcinoma. Korean J Intern Med; 2007 Mar;22(1):55-8
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  • [Title] Acral metastasis in a patient with ampullary carcinoma.
  • Although skin metastasis from a malignant tumor of an internal organ usually occurs at an advanced disease stage, there has been no prior report of a cutaneous acral metastasis from ampullary carcinoma to date.
  • We report a 71-year old male patient with cutaneous metastasis from an ampullary adenocarcinoma.
  • The patient had a history of pylorus preserving pancreaticoduodenectomy for carcinoma of the ampulla of Vater two years prior to presentation.
  • This case illustrates that cutaneous metastasis from ampullary carcinoma has a poor prognosis.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 17427649.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2687605
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2. Chong VH, Telisinghe PU, Yapp SK, Jalihal A: Biliary strictures secondary to tuberculosis and early ampullary carcinoma. Singapore Med J; 2009 Mar;50(3):e94-6
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  • [Title] Biliary strictures secondary to tuberculosis and early ampullary carcinoma.
  • Malignancies are important causes and are often unresectable at the time of diagnosis.
  • We report a 67-year-old man with unexpected findings of obstructive jaundice secondary to biliary TB and an early ampullary tumour.
  • [MeSH-minor] Aged. Ampulla of Vater / pathology. Biliary Tract Surgical Procedures. Constriction, Pathologic / pathology. Humans. Male. Risk Factors

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  • (PMID = 19352560.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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3. Foo FJ, Gill U, Verbeke CS, Guthrie JA, Menon KV: Ampullary carcinoma associated with an annular pancreas. JOP; 2007;8(1):50-4
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  • [Title] Ampullary carcinoma associated with an annular pancreas.
  • CASE REPORT: We present a case report of a 78-year-old woman with jaundice due to an ampullary carcinoma associated with an annular pancreas treated by pancreaticoduodenectomy.
  • [MeSH-minor] Aged. Ampulla of Vater / surgery. Female. Humans. Pancreaticoduodenectomy

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  • (PMID = 17228134.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 21
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4. Aksoy M, Sumer A, Sari S, Mete O, Salmaslioglu A, Erbil Y: Pancreatic ampullary carcinoma with neck metastases: a case report. Cases J; 2009;2:146

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancreatic ampullary carcinoma with neck metastases: a case report.
  • CASE REPORT: She was diagnosed of ampullary carcinoma for which pancreatoduodenectomy was performed 14 months ago.
  • Histopathological examination revealed the metastasis of the precedent ampullary adenocarcinoma.
  • CONCLUSION: Surgery does not improve survival for advanced metastatic ampullary cancer however, it can be mandatory in specific conditions as our patient.

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  • (PMID = 19946517.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2783102
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5. Sakata J, Shirai Y, Wakai T, Yokoyama N, Sakata E, Akazawa K, Hatakeyama K: Number of positive lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma. Eur J Surg Oncol; 2007 Apr;33(3):346-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Number of positive lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma.
  • AIM: The nodal status is an established prognostic factor in ampullary carcinoma.
  • METHODS: Of 73 consecutive patients treated for ampullary carcinoma, 62 underwent pancreaticoduodenectomy with regional lymphadenectomy.
  • CONCLUSION: The number, not the location, of positive regional lymph nodes independently affects long-term survival after resection in patients with ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Lymph Nodes / pathology

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  • (PMID = 17097846.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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6. Santini D, Baldi A, Vincenzi B, Mellone P, Campioni M, Antinori A, Borzomati D, Coppola R, Magistrelli P, Tonini G: Mucin 2 (MUC2) and mucin 5 (MUC5) expression is not associated with prognosis in patients with radically resected ampullary carcinoma. J Clin Pathol; 2007 Sep;60(9):1069-70
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  • [Title] Mucin 2 (MUC2) and mucin 5 (MUC5) expression is not associated with prognosis in patients with radically resected ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater. Biomarkers, Tumor / metabolism. Common Bile Duct Neoplasms / metabolism. Mucins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Mucin-2. Mucin-5B. Neoplasm Proteins / metabolism. Prognosis. Survival Analysis

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  • (PMID = 17761747.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / MUC5B protein, human; 0 / Mucin-2; 0 / Mucin-5B; 0 / Mucins; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC1972431
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7. Neves P, Leitão M, Portela F, Pontes JM, Areia M, Brito D, Sousa HT, Souto P, Camacho E, Andrade P, Gouveia H, Freitas D: Endoscopic resection of ampullary carcinoma. Endoscopy; 2006 Jan;38(1):101
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  • [Title] Endoscopic resection of ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Endoscopy, Digestive System. Pancreatic Neoplasms / surgery

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  • (PMID = 16429371.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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8. Giannopoulos G, Pavlakis K, Parasi A, Kavatzas N, Tiniakos D, Karakosta A, Tzanakis N, Peros G: The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters. Anticancer Res; 2008 May-Jun;28(3B):1875-81
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  • [Title] The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters.
  • AIM: To investigate the expression of metalloproteinase (MMP) -2, MMP-9 and tissue inhibitor of MMP (TIMP) -2 in pancreatic ductal and ampullary carcinoma and to test the findings for correlation with angiogenesis and several clinicopathological parameters.
  • PATIENTS AND METHODS: Paraffin sections from 32 pancreatic ductal adenocarcinomas and 17 ampullary carcinomas were assessed for the expression of MMP-2, MMP-9 and TIMP-2 by immunohistochemistry.
  • RESULTS: In pancreatic ductal adenocarcinoma, lower levels of glandular TIMP-2 were found in poorly differentiated tumors, while high glandular TIMP-2 expression was significantly associated with better survival.
  • In ampullary adenocarcinoma, strong expression of glandular MMP-2 was associated with higher MVD values.
  • CONCLUSION: In pancreatic ductal adenocarcinoma, TIMP-2 may have a more crucial role in prognosis than MMP-2, MMP-9 or angiogenesis.
  • In ampullary adenocarcinoma, MMP-2 expression correlated with MVD, supporting its postulated role in angiogenesis.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / enzymology. Matrix Metalloproteinase 2 / biosynthesis. Matrix Metalloproteinase 9 / biosynthesis. Pancreatic Neoplasms / enzymology. Tissue Inhibitor of Metalloproteinase-2 / biosynthesis
  • [MeSH-minor] Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Neovascularization, Pathologic / enzymology. Neovascularization, Pathologic / pathology

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  • (PMID = 18630474.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.24 / MMP2 protein, human; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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9. Shimizu Y, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Miyazaki M: The morbidity, mortality, and prognostic factors for ampullary carcinoma and distal cholangiocarcinoma. Hepatogastroenterology; 2008 Mar-Apr;55(82-83):699-703
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  • [Title] The morbidity, mortality, and prognostic factors for ampullary carcinoma and distal cholangiocarcinoma.
  • BACKGROUND/AIMS: Ampullary carcinoma and distal cholangiocarcinoma are potentially more amenable to pancreaticoduodenectomy for long-term survival than pancreatic carcinoma.
  • The aims of this study are to evaluate experience with ampullary carcinoma and distal cholangiocarcinoma at a single institution.
  • METHODOLOGY: Seventy-two consecutive patients with ampullary carcinoma and distal cholangiocarcinoma who underwent radical resection at Chiba University Hospital from 1985 to 2001.
  • RESULTS: Pancreaticoduodenectomy was performed in 37 of 38 patients for ampullary carcinoma and 29 of 34 patients for distal cholangiocarcinoma.
  • The morbidity rates of patients with ampullary carcinoma and distal cholangiocarcinoma were 21.1% and 20.6%, and mortality rates were 0% and 2.9%, respectively.
  • The cumulative 5-year survival rates in cases of ampullary carcinoma and distal cholangiocarcinoma were 63% and 45%, respectively.
  • By univariate analysis, pancreatic invasion, lymph node metastasis, and duodenal invasion were significant prognostic factors for ampullary carcinoma.
  • Multivariate analysis indicated that lymph node metastasis was the only independent prognostic factor for ampullary carcinoma, and that perineural invasion was the only independent prognostic factor for distal cholangiocarcinoma.
  • CONCLUSIONS: The overall mortality of 1.4% and the cumulative 5-year survival rates for ampullary carcinoma and distal cholangiocarcinoma are acceptable.
  • Ampullary carcinoma with lymph node metastasis and distal cholangiocarcinoma with perineural invasion have higher risk of recurrence.
  • [MeSH-major] Ampulla of Vater. Bile Duct Neoplasms / mortality. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Cholangiocarcinoma / mortality. Cholangiocarcinoma / surgery

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  • (PMID = 18613437.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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10. Bhangle SD, Kramer N, Rosenstein ED: Spondyloarthropathy after ampullary carcinoma resection: "post-Whipple" disease. J Clin Rheumatol; 2009 Aug;15(5):241-3
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  • [Title] Spondyloarthropathy after ampullary carcinoma resection: "post-Whipple" disease.
  • The development of bowel-bypass syndrome complicating the Whipple procedure for biliary tract carcinoma is described here for the first time.
  • A 56-year-old HLA-B27 + man, treated with excision of adenocarcinoma of the ampulla of Vater, developed an undifferentiated spondyloarthropathy, initially unresponsive to nonsteroidal anti-inflammatory drugs and doxycycline, but eventually controlled with sulfasalazine and tapered corticosteroids.

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  • (PMID = 19590445.001).
  • [ISSN] 1536-7355
  • [Journal-full-title] Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • [ISO-abbreviation] J Clin Rheumatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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11. Sudo T, Murakami Y, Uemura K, Hayashidani Y, Hashimoto Y, Ohge H, Shimamoto F, Sueda T: Prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma. Dig Dis Sci; 2008 Aug;53(8):2281-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic impact of perineural invasion following pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma.
  • The aim of this study was to identify prognostic factors in patients undergoing pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma.
  • The records of 46 consecutive patients with ampullary carcinoma who underwent pancreatoduodenectomy from 1988 through 2006 were retrospectively reviewed.
  • Univariate analysis revealed that T3 and T4 tumor (i.e., pancreatic parenchymal invasion) (P < 0.001), lymph node metastasis (P = 0.01), and perineural invasion (P < 0.001) were significant predictors of poor prognosis.
  • Pancreatoduodenectomy with lymphadenectomy for ampullary carcinoma is a safe surgical procedure with an acceptable cure rate.
  • The presence of perineural invasion may be useful for predicting poor prognosis in patients with ampullary carcinoma who undergo potentially curative resection.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Lymph Node Excision. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Duodenum / pathology. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Pancreas / pathology. Retrospective Studies. Treatment Outcome

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  • (PMID = 18095164.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Abe N, Sugiyama M, Mizuno H, Suzuki Y, Masaki T, Mori T, Atomi Y: Advanced ampullary carcinoma showing complete response to S-1: report of a case. Surg Today; 2010 Jun;40(6):574-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advanced ampullary carcinoma showing complete response to S-1: report of a case.
  • We report a case of advanced ampullary carcinoma with para-aortic lymph node metastasis, which showed a complete response to S-1.
  • Thus, S-1 monotherapy may be considered as a chemotherapeutic strategy for unresectable ampullary carcinoma, although large-scale studies will be required to confirm its true efficacy.
  • [MeSH-major] Ampulla of Vater. Antimetabolites, Antineoplastic / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

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  • (PMID = 20496142.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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13. Ishii Y, Takahashi M, Yoshida S, Suzuki K: [A case of hepatic metastases of ampullary carcinoma which completely responded to intrahepatic infusion of 5-FU with low-dose l-leucovorin]. Gan To Kagaku Ryoho; 2005 Aug;32(8):1175-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of hepatic metastases of ampullary carcinoma which completely responded to intrahepatic infusion of 5-FU with low-dose l-leucovorin].
  • A 70-year-old man was admitted with an ampullary carcinoma with multiple hepatic metastases.
  • [MeSH-major] Ampulla of Vater. Duodenal Neoplasms / pathology. Fluorouracil / administration & dosage. Leucovorin / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 16121924.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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14. Sakata E, Shirai Y, Yokoyama N, Wakai T, Sakata J, Hatakeyama K: Clinical significance of lymph node micrometastasis in ampullary carcinoma. World J Surg; 2006 Jun;30(6):985-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical significance of lymph node micrometastasis in ampullary carcinoma.
  • BACKGROUND: This study aimed to clarify the clinical significance of lymph node micrometastasis in ampullary carcinoma.
  • MATERIALS AND METHODS: Pancreaticoduodenectomy with regional lymphadenectomy was performed for 50 consecutive patients with ampullary carcinoma.
  • CONCLUSIONS: Immunohistochemically detected lymph node micrometastasis indicates intensive lymphatic spread, and thus adversely affects the survival of patients with ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Keratins / analysis. Lymph Node Excision. Lymph Nodes / chemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Pancreaticoduodenectomy. Prognosis. Survival Rate

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  • (PMID = 16736326.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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15. Schultz NA, Roslind A, Christensen IJ, Gaustadnes M, Johansen JS, Kruhøffer M, Horn T, Wøjdemann M: KRAS mutations and relation to prognosis in patients operated for localized pancreatic cancer and other periampullary cancers. J Clin Oncol; 2009 May 20;27(15_suppl):e15618

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  • [Title] KRAS mutations and relation to prognosis in patients operated for localized pancreatic cancer and other periampullary cancers.
  • : e15618 Background: Prognostic biomarkers in patients with pancreatic cancer might direct patients to optimal treatment.
  • We studied the prognostic value of KRAS mutations in patients operated for pancreatic and other periampullary cancers.
  • For the present pilot study cancer tissue blocks were collected from 58 patients (31 men, 27 women, median age 64, range 33-81 years, ASA 1-3).
  • All had localized pancreatic (n=26), ampullary (n=26) or duodenal cancer (n=6) and were operated during the period June 2001 to May 2008.
  • RESULTS: KRAS mutations were found in 32 (55%) of the patients; 16 (62%) patients with pancreatic cancer, 13 (50%) with ampullary cancer and in 3 (50%) with duodenal cancer.
  • KRAS status was neither associated with type of cancer (p=0.68), TNM stage (T stage p=0.64, N stage p=0.31).
  • CONCLUSIONS: KRAS mutations are frequent in patients with localized pancreatic, ampullary and duodenal cancers.

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  • (PMID = 27962729.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Ohno T, Koguchi H, Miura A, Tanaka Y, Endo M, Matsunaga S, Hasegawa I, Kato A, Tokuda Y, Sakakibara K: [A case of advanced ampullary carcinoma successfully resected after primary chemotherapy with s-1 and gemcitabine]. Gan To Kagaku Ryoho; 2009 Jun;36(6):999-1002
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  • [Title] [A case of advanced ampullary carcinoma successfully resected after primary chemotherapy with s-1 and gemcitabine].
  • He was diagnosed as having advanced ampullary carcinoma(T4 N0 H1, Stage IV b).
  • This is a very instructive case for developing effective chemotherapy options to treat biliary tract cancers involving ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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  • (PMID = 19542724.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0W860991D6 / Deoxycytidine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; B76N6SBZ8R / gemcitabine
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17. Sonoue H, Suda K, Nobukawa B, Abe H, Arakawa A, Hirai S, Matsumoto T: Does ampullary carcinoma arise from distended glands in the papilla of Vater? J Hepatobiliary Pancreat Surg; 2008;15(2):161-8
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  • [Title] Does ampullary carcinoma arise from distended glands in the papilla of Vater?
  • BACKGROUND/PURPOSE: Glands near the surface of the papilla of Vater may become distended with mucus and become hyperplastic; that is, become distended.
  • METHODS: Twenty-nine pancreatoduodenectomized nontumorous duodenal papilla specimens from carcinoma of the pancreas and bile duct and 34 resected ampullary carcinoma specimens were studied histopathologically and immunohistochemically, using cytokeratins and mucin immunohistochemical features/phenotypes.
  • Immunopositivity for CK7, CK20, and MUC5AC was found in 25, 21, and 18 of the 34 specimens of ampullary carcinoma, respectively.
  • CONCLUSIONS: Although most ampullary carcinomas arise from the duodenal mucosa or intra-ampullary mucosa, both CK7-positive and MUC5AC-positive or only MUC5ACpositive ampullary carcinomas may arise from the distended glands.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology

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  • (PMID = 18392709.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Keratin-7; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
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18. O'Connell JB, Maggard MA, Manunga J Jr, Tomlinson JS, Reber HA, Ko CY, Hines OJ: Survival after resection of ampullary carcinoma: a national population-based study. Ann Surg Oncol; 2008 Jul;15(7):1820-7
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  • [Title] Survival after resection of ampullary carcinoma: a national population-based study.
  • BACKGROUND: Ampullary cancer is the second most common periampullary cancer, with a resection and survival rate more favorable than that for pancreatic cancer.
  • Our objective was to complete a population-based analysis of patients undergoing resection for ampullary carcinoma and compare it with outcomes in the published literature.
  • METHODS: Patients diagnosed with ampullary cancer reported in the Surveillance, Epidemiology, and End Results program (1988-2003) were collected.
  • RESULTS: Of the 3292 ampullary cancer patients, 1301 (40%) underwent resection.
  • The cancer registry data showed less early stage disease, higher perioperative mortality, and lower 5-year survival compared with published reports.
  • CONCLUSIONS: This is the largest population-based analysis of ampullary carcinoma.
  • Resection rates and survival at the national level are lower, in general, compared with cancer center reports, which may have implications for regionalizing these procedures.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Survival Analysis. Survival Rate. Treatment Outcome

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  • [CommentIn] Ann Surg Oncol. 2008 Jul;15(7):1813-4 [18425553.001]
  • (PMID = 18369675.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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19. Agaram NP, Shia J, Tang LH, Klimstra DS: DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases. Am J Clin Pathol; 2010 May;133(5):772-80
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  • [Title] DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases.
  • The significance of DNA mismatch repair (MMR) deficiency or microsatellite instability (MSI) in ampullary carcinomas remains to be defined.
  • This study evaluated the MMR status in 54 consecutive ampullary adenocarcinomas by immunohistochemical and morphologic studies.
  • Thus, MMR deficiency occurs in ampullary carcinoma but appears less frequent than in colorectal carcinoma (CRC).
  • Typical MSI-high histologic features of CRC, such as increased TIL counts, seem to have similar yet subtly different implications in ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair / genetics. Nuclear Proteins

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  • (PMID = 20395525.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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20. Perrone G, Santini D, Zagami M, Vincenzi B, Verzì A, Morini S, Borzomati D, Coppola R, Antinori A, Magistrelli P, Tonini G, Rabitti C: COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters. Virchows Arch; 2006 Sep;449(3):334-40

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  • [Title] COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters.
  • Epidemiological studies suggest that regular intake of nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with reduced incidence of gastrointestinal cancer.
  • The aim of our study was to assess COX-2 expression in a series of primary untreated ampullary carcinomas and its possible correlation with clinicopathological parameters.
  • In the present study, 45 surgical specimens of invasive ampullary carcinomas were histologically classified into pancreaticobiliary, intestinal, and unusual types.
  • High COX-2 expression was detected in 35 (77.8%) ampullary carcinomas.
  • The different COX-2 expression among histopathological types supports the concept of histogenetical difference of ampullary carcinomas.
  • Furthermore, the high rate of COX-2 expression in the intestinal subtype of ampullary carcinoma may represent the rational for a histotype-tailored therapy targeting COX-2.
  • [MeSH-major] Adenocarcinoma / enzymology. Ampulla of Vater / enzymology. Common Bile Duct Neoplasms / enzymology. Cyclooxygenase 2 / metabolism

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  • (PMID = 16906389.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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21. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today; 2008;38(5):440-4
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  • [Title] Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
  • A 58-year-old man who had undergone total colectomy for FAP 18 years earlier was hospitalized for carcinoma arising from the residual rectum.
  • He had severe diabetes mellitus, but had no symptoms of pancreatic exocrine dysfunction.
  • Upper endoscopy showed multiple duodenal adenomas including carcinoma involving the papilla of Vater.
  • To remove these duodenal adenomas and ampullary carcinoma and prevent recurrent pancreatitis, we performed pancreaticoduodenectomy.
  • On pathologic examination, the major duodenal papilla was completely obstructed by the carcinoma, and the minor papilla was also involved by the adenoma.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications. Ampulla of Vater. Common Bile Duct Neoplasms / etiology. Pancreatic Neoplasms / etiology. Pancreatitis / etiology
  • [MeSH-minor] Humans. Male. Middle Aged. Pancreatic Ducts. Pancreaticoduodenectomy. Recurrence

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  • (PMID = 18560968.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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22. Santini D, Vincenzi B, Perrone G, Rabitti C, Borzomati D, Valeri S, Coppola R, Magistrelli P, Tonini G: Vascular endothelial growth factor (VEGF) expression is not associated with prognosis in patients with radically resected ampullary carcinoma. Ann Oncol; 2005 Nov;16(11):1847-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vascular endothelial growth factor (VEGF) expression is not associated with prognosis in patients with radically resected ampullary carcinoma.

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  • (PMID = 15972277.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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23. Santini D, Tonini G, Vecchio FM, Borzomati D, Vincenzi B, Valeri S, Antinori A, Castri F, Coppola R, Magistrelli P, Nuzzo G, Picciocchi A: Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma. J Clin Pathol; 2005 Feb;58(2):159-65
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  • [Title] Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma.
  • BACKGROUND: There is a lack of data in the literature concerning the identification of potential prognostic factors in ampullary adenocarcinoma.
  • AIMS: To examine the prognostic significance of Bax, Bcl-2, and p53 protein expression and the apoptotic index in a large cohort of uniformly treated patients with radically resected ampullary cancer.
  • METHODS: All patients with a pathological diagnosis of ampullary cancer and radical resection were evaluated.
  • RESULTS: Thirty nine tumour specimens from patients with radically resected ampullary adenocarcinoma were studied.
  • CONCLUSIONS: These results provide evidence that apoptosis may be an important prognostic factor in patients with radically resected ampullary cancer.
  • This study is the first to assess the clinical usefulness of Bax expression in radically resected ampullary cancer.
  • [MeSH-major] Adenocarcinoma / chemistry. Ampulla of Vater. Common Bile Duct Neoplasms / chemistry. In Situ Nick-End Labeling / methods. Proto-Oncogene Proteins c-bcl-2 / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15677536.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC1770581
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24. Kamisawa T, Tu Y, Egawa N, Nakajima H, Horiguchi S, Tsuruta K, Okamoto A: Clinicopathologic features of ampullary carcinoma without jaundice. J Clin Gastroenterol; 2006 Feb;40(2):162-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic features of ampullary carcinoma without jaundice.
  • GOALS: To evaluate clinicopathological features of ampullary carcinoma without jaundice.
  • BACKGROUND: : Obstructive jaundice is the most common symptom of patients with ampullary carcinoma.
  • However, some patients with ampullary carcinoma do not have jaundice at the time of diagnosis.
  • STUDY: Clinicopathologic findings of 23 patients with ampullary carcinoma showing no visible jaundice (serum total bilirubin <3.0 mg/dL) and 38 patients with ampullary carcinoma showing jaundice at the time of diagnosis were retrospectively compared.
  • RESULTS: Fifteen of 23 patients with nonjaundiced ampullary carcinoma complained of fever and/or abdominal pain.
  • Five asymptomatic patients were found to have a dilated bile duct on screening ultrasound or to have a tumor-like swelling of the papilla of Vater during routine upper gastrointestinal endoscopy.
  • There was no significant difference in age, sex, size, macroscopic type, histologic type, rates of duodenal invasion, pancreatic invasion, and lymph node metastasis, and prognosis between the two groups.
  • Ten of the 23 nonjaundiced ampullary carcinomas (43%) were in Stage I, whereas 4 of the 38 jaundiced ampullary carcinomas (11%) were in Stage I (P < 0.01).
  • Mechanisms of nonjaundice in ampullary carcinoma were suspected to be determinant by the infiltrating pattern of the carcinoma to the lower portion of the bile duct.
  • CONCLUSIONS: Mechanisms of nonjaundice in ampullary carcinoma might be determined by the infiltrating pattern of the carcinoma to the lower portion of the bile.
  • As a greater number of nonjaundiced ampullary carcinomas were in an early stage, detection of them may provide an improved clinical outcome.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 16394879.001).
  • [ISSN] 0192-0790
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Kirimlioğlu H, Türkmen I, Başsüllü N, Dirican A, Karadağ N, Kirimlioğlu V: The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. Turk J Gastroenterol; 2009 Mar;20(1):41-7
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  • [Title] The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma.
  • METHODS: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study.
  • MMP-2 expression was detected in the distal part of the biliary ducts, in 75% (6/18) of cases and in the nontumoral epithelia of the ampullary region in 50% (5/10) of cases.
  • The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors.
  • The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively.
  • MMP-9 and MMP- 14 were present in metaplasia, dysplasia carcinoma sequence in all of the bile tract tumors, suggesting that MMPs play an important role in carcinogenesis.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Ampulla of Vater / enzymology. Ampulla of Vater / pathology. Disease Progression. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Hepatic Duct, Common / enzymology. Hepatic Duct, Common / pathology. Humans. Immunohistochemistry. Klatskin Tumor / metabolism. Klatskin Tumor / pathology. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness. Prognosis

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  • (PMID = 19330734.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.80 / Matrix Metalloproteinase 14
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26. Kawabata Y, Tanaka T, Nishisaka T, Inao T, Nishi T, Yano S: Cytokeratin 20 (CK20) and apomucin 1 (MUC1) expression in ampullary carcinoma: Correlation with tumor progression and prognosis. Diagn Pathol; 2010;5:75
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  • [Title] Cytokeratin 20 (CK20) and apomucin 1 (MUC1) expression in ampullary carcinoma: Correlation with tumor progression and prognosis.
  • BACKGROUND: We assessed the expression of cytokeratin (CK) and apomucin (MUC) in ampullary carcinoma (AC) to develop a system for the classification of ACs on the basis of their clinical significance.
  • [MeSH-major] Ampulla of Vater / chemistry. Biomarkers, Tumor / analysis. Carcinoma / chemistry. Common Bile Duct Neoplasms / chemistry. Mucin-1 / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Disease Progression. Female. Humans. Immunohistochemistry. Japan. Kaplan-Meier Estimate. Keratin-20 / analysis. Male. Middle Aged. Mucin 5AC / analysis. Mucin-6 / analysis. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 21106111.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT20 protein, human; 0 / Keratin-20; 0 / MUC1 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-1; 0 / Mucin-6
  • [Other-IDs] NLM/ PMC3003636
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27. Chen WX, Xie QG, Zhang WF, Zhang X, Hu TT, Xu P, Gu ZY: Multiple imaging techniques in the diagnosis of ampullary carcinoma. Hepatobiliary Pancreat Dis Int; 2008 Dec;7(6):649-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple imaging techniques in the diagnosis of ampullary carcinoma.
  • BACKGROUND: Ampullary carcinoma is a neoplasia with a good prognosis compared to pancreatic cancer.
  • This study aimed to evaluate the efficacy of abdominal ultrasonography (US), enhanced computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) in detecting ampullary carcinoma.
  • METHODS: Forty-one patients with ampullary carcinoma who had been confirmed pathologically among the inpatients at the First Affiliated Hospital of Zhejiang University School of Medicine from February 2003 to March 2007 were analyzed retrospectively.
  • The accuracy of US, CT, MRCP and ERCP were compared in the diagnosis of ampullary carcinoma.
  • RESULTS: The accurate rate for detection of ampullary carcinoma with US was 26.83%.
  • The accuracy of CT and ERCP in detection of ampullary tumors was 84.62% and 100%, respectively, which were significantly higher than that of US (P<0.05).
  • The accuracy of MRCP in detection of ampullary tumors was similar to that of US in spite of visualization of obstruction and dilatation of the pancreaticobiliary duct with MRCP.
  • CONCLUSIONS: Because of the obscure and late onset of symptoms, ampullary carcinoma is difficult to diagnose early.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Papillary / diagnosis. Bile Duct Neoplasms / diagnosis. Diagnostic Techniques, Digestive System / standards
  • [MeSH-minor] Adult. Aged. Ampulla of Vater. Cholangiopancreatography, Endoscopic Retrograde / standards. Diagnosis, Differential. Early Diagnosis. Humans. Magnetic Resonance Imaging / standards. Middle Aged. Prognosis. Reproducibility of Results. Retrospective Studies. Tomography, X-Ray Computed / standards. Ultrasonography / standards

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  • (PMID = 19073413.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Validation Studies
  • [Publication-country] China
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28. Alsaif F: Pylorus preserving pancreaticoduodenectomy for peri-ampullary carcinoma, is it a good option? Saudi J Gastroenterol; 2010 Apr-Jun;16(2):75-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pylorus preserving pancreaticoduodenectomy for peri-ampullary carcinoma, is it a good option?
  • Pancreaticoduodenectomy (PD) is the standard surgical treatment for resectable peri-ampullary tumors.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / surgery. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods. Pylorus
  • [MeSH-minor] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Anastomosis, Surgical / adverse effects. Anastomosis, Surgical / methods. Blood Loss, Surgical. Blood Transfusion. Female. Follow-Up Studies. Gastric Emptying / physiology. Hospital Mortality / trends. Humans. Intraoperative Complications / mortality. Length of Stay. Male. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Postoperative Complications / mortality. Postoperative Complications / prevention & control. Randomized Controlled Trials as Topic. Survival Analysis. Treatment Outcome

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  • [CommentIn] Saudi J Gastroenterol. 2010 Apr-Jun;16(2):65 [20339172.001]
  • (PMID = 20339174.001).
  • [ISSN] 1998-4049
  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • [ISO-abbreviation] Saudi J Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Saudi Arabia
  • [Number-of-references] 36
  • [Other-IDs] NLM/ PMC3016509
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29. Kamisawa T, Tu Y, Egawa N, Tsuruta K, Okamoto A, Funata N: Endocrine cells in ampullary carcinoma. J Hepatobiliary Pancreat Surg; 2009;16(3):322-7
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  • [Title] Endocrine cells in ampullary carcinoma.
  • BACKGROUND/PURPOSE: As ampullary carcinoma originates from four anatomical regions, it may have different behaviors depending on its origin.
  • We documented the presence of endocrine cells found in ampullary carcinoma, and we studied the clinicopathological implications of their presence.
  • METHODS: We immunohistochemically examined the presence of an endocrine component in 62 surgically resected specimens of ampullary carcinoma, and we studied the clinicopathological differences between endocrine component-positive cases and endocrine component-negative cases.
  • The histology of 15 of the 16 endocrine component-positive ampullary carcinomas was the intestinal type.
  • Pancreatic invasion and lymph node involvement were observed less frequently in endocrine component-positive cases (P < 0.01).
  • CONCLUSIONS: Endocrine component-positive ampullary carcinoma seemed to be derived from the ampullopancreaticobiliary common duct or the ampulloduodenum, and to behave less aggressively than endocrine component-negative carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Endocrine Cells / pathology. Neoplasm Invasiveness / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 19214369.001).
  • [ISSN] 1436-0691
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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30. Morris-Stiff G, Alabraba E, Tan YM, Shapey I, Bhati C, Tanniere P, Mayer D, Buckels J, Bramhall S, Mirza DF: Assessment of survival advantage in ampullary carcinoma in relation to tumour biology and morphology. Eur J Surg Oncol; 2009 Jul;35(7):746-50
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  • [Title] Assessment of survival advantage in ampullary carcinoma in relation to tumour biology and morphology.
  • INTRODUCTION: Carcinoma of the ampulla of Vater is said to carry a significantly better prognosis than pancreatic ductal adenocarcinomas arising in the pancreatic head.
  • However, it is uncertain as to whether this is due to the fact that they have differing oncological characteristics or simply an earlier presentation as a result of the exophytic morphology of ampullary lesions causing obstruction of the bile ducts.
  • Patients with a pathologically confirmed ampullary (AMP) tumour were compared to those with a carcinoma of the head of the pancreas (HOP).
  • Subdivision of AMP carcinoma into polypoid (60%) and ulcerating (40%) lesions revealed a non-significant survival advantage in favour of polypoid tumours at (64% vs. 60%; p = 0.07) at 5 years.
  • CONCLUSIONS: The outcome of resection for AMP is significantly better than for pancreatic ductal adenocarcinomas arising in the periampullary region.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 19167859.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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31. Shiba H, Misawa T, Wakiyama S, Iida T, Ishida Y, Yanaga K: Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case. J Gastrointest Cancer; 2010 Jun;41(2):138-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case.
  • CASE REPORT: A 30-year-old woman was admitted to our hospital for treatment of an ampullary tumor.
  • Upper gastrointestinal endoscopy revealed a pedunculated tumor in the ampulla of Vater with a diameter of 50 mm, which was biopsied and diagnosed as tubulovillous adenoma with moderate atypia.
  • DISCUSSION: Ampullectomy is an established method for ampullary tumor, but such a tumor with a long stalk is rare.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 20012229.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Kamisawa T, Egawa N, Tsuruta K, Okamoto A, Horiguchi S, Funata N: An investigation of primary malignancies associated with ampullary carcinoma. Hepatogastroenterology; 2005 Jan-Feb;52(61):22-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An investigation of primary malignancies associated with ampullary carcinoma.
  • BACKGROUND/AIMS: As ampullary carcinoma has a favorable prognosis, associated malignancies have potential prognostic significance in these patients.
  • This study focused on the incidence and characteristics of preexisting, coexisting and subsequent malignancies in patients with ampullary carcinoma.
  • METHODOLOGY: Sixty-four cases of ampullary carcinoma were retrospectively identified.
  • Fifty-four patients underwent surgical resection, while in the other ten, histological diagnosis was reached after biopsy and/or autopsy.
  • Other primary malignancies associated with ampullary carcinoma, occurring in the prediagnostic or postdiagnostic period, were investigated.
  • RESULTS: Other malignancies occurred in 17 patients (27%), being found before (n=9), at (n=7), or after (n=5) diagnosis of ampullary carcinoma.
  • The total number of associated lesions was 23, including one case of quadruple and four cases of triple carcinoma.
  • The major associated malignancies were colonic carcinoma (n=9), gastric carcinoma (n=5), and uterine carcinoma (n=3).
  • One patient died from synchronous extrahepatic bile duct carcinoma and one from leukemia, and one died from subsequent urinary bladder carcinoma.
  • CONCLUSIONS: Ampullary carcinoma is associated with a high incidence of other malignancies, particularly colonic and gastric carcinomas.
  • The possibility of associated malignancies should therefore be considered in preoperative screening and postoperative follow-up of patients with ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 15782985.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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33. Woo SM, Ryu JK, Lee SH, Yoo JW, Park JK, Kim YT, Jang JY, Kim SW, Kang GH, Yoon YB: Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma. Ann Surg Oncol; 2007 Nov;14(11):3195-201

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma.
  • BACKGROUND: Ampullary carcinoma is often considered to have a better prognosis than distal extrahepatic cholangiocarcinoma.
  • METHODS: Clinicopathologic factors and the long-term outcomes of 163 patients with ampullary carcinoma after radical resection were retrospectively evaluated and compared with those of 91 patients with distal extrahepatic cholangiocarcinoma.
  • RESULTS: Among the 163 ampullary carcinomas, T1 stage, well-differentiated tumors and perineural invasion were 45 (28%), 73 (45%), and 23 (14%), respectively, whereas, only five (6%) were T1 stage, 15 (17%) were well differentiated, and 63 (69%) showed perineural invasion (p < 0.001, for all) in distal extrahepatic cholangiocarcinomas.
  • More patients with distal extrahepatic cholangiocarcinoma had liver metastasis than ampullary carcinoma (24% vs. 10%, p = 0.004).
  • Multivariate analysis identified venous invasion and perineural invasion as risk factors for recurrence of ampullary carcinoma after radical resection.
  • Overall five-year survival of patients with ampullary cancer was higher than that of patients with distal extrahepatic cholangiocarcinoma (68% vs. 54%; p = 0.033).
  • CONCLUSION: Earlier diagnosis and the less frequent occurrence of pathological factors associated with tumor invasiveness in ampullary carcinoma than in distal extrahepatic cholangiocarcinoma may explain its association with a better prognosis.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Extrahepatic / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17710498.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Kalogeraki A, Tzardi M, Papadakis M, Stathopoulos E, Kouroumalis E, Zoras O: Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma. Acta Cytol; 2010 Jan-Feb;54(1):39-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma.
  • OBJECTIVE: To evaluate apoptosis and cell proliferation on cytologic specimens (smears) from endoscopic retrograde cholangiopancreatography in patients with ampulary carcinoma and to correlate that relationship with the grade of the tumors.
  • STUDY DESIGN: Forty patients (23 males and 17 females) aged 45-81 who underwent endoscopic retrograde cholangiopancreatography were diagnosed by cytology as having ampullary adenocarcinoma and the diagnoses were confirmed histologically after an operation.
  • RESULTS: The TUNEL indices were 0.4 +/- 0.07, 0.91 +/- 0.33 and 3.1 +/- 0.9 in well, moderate and poorly differentiated ampullary carcinoma, respectively.
  • The differences in both TUNEL and MIB-1 labeling indices were statistically significant between well, moderately and poorly differentiated ampullary carcinoma, and a positive correlation was found between TUNEL and the MIB-1 indices.
  • CONCLUSION: Apoptosis (cell death) and cell proliferation increase as the grade of the differentiation decreases in ampullary carcinoma, suggesting a rapid turnover of the tumor cells with lower grates of differentiation, and apoptosis may play an important role in the growth of the tumors in patients with ampullary carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Apoptosis. Cell Proliferation. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Antinuclear / analysis. Antibodies, Monoclonal / analysis. DNA Fragmentation. Female. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 20306986.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody
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35. Sato Y, Ohwada S, Oyama T, Kashiwabara K, Totsuka O, Yamada T, Morishita Y: Ampullary carcinoma associated with protein-losing gastropathy due to diffuse varioliform gastritis. Hepatogastroenterology; 2005 Jul-Aug;52(64):1143-6

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  • [Title] Ampullary carcinoma associated with protein-losing gastropathy due to diffuse varioliform gastritis.
  • Protein-losing gastropathy due to diffuse varioliform gastritis is a rare condition, and its occurrence accompanying ampullary carcinoma is particularly rare.
  • We report here a case of ampullary carcinoma accompanied with protein-losing gastroenteropathy due to diffuse varioliform gastritis.
  • Upper gastrointestinal endoscopic examination showed diffuse varioliform gastritis and carcinoma of the papilla of Vater.
  • A diagnosis of protein-losing gastropathy was made based on the results of scintigraphy using technetium 99m-labeled human albumin.
  • Continuous bleeding from ampullary carcinoma caused anemia and deteriorated hypoproteinemia.
  • Pancreaticoduodenectomy was performed for ampullary carcinoma prior to Helicobacter pylori eradication.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Gastritis, Hypertrophic / pathology. Protein-Losing Enteropathies / etiology
  • [MeSH-minor] Adult. Female. Helicobacter Infections / diagnosis. Helicobacter Infections / therapy. Helicobacter pylori. Humans. Pancreaticoduodenectomy

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  • (PMID = 16001648.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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36. Yokoyama N, Shirai Y, Wakai T, Nagakura S, Akazawa K, Hatakeyama K: Jaundice at presentation heralds advanced disease and poor prognosis in patients with ampullary carcinoma. World J Surg; 2005 Apr;29(4):519-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Jaundice at presentation heralds advanced disease and poor prognosis in patients with ampullary carcinoma.
  • Jaundice is a common manifestation of ampullary carcinoma.
  • The aim of this study was to evaluate the correlation between jaundice at initial presentation and the degree of tumor spread and to determine the prognostic significance of jaundice in patients with ampullary carcinoma.
  • Fifty-nine patients who had undergone curative resection for ampullary carcinoma were analyzed retrospectively.
  • Pancreatic invasion was absent in patients without jaundice.
  • In conclusion, jaundice at presentation predicts advanced-stage ampullary carcinoma and a poor prognosis.
  • Pancreatic invasion and superior mesenteric nodal involvement were not observed in nonjaundiced patients.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Jaundice / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymph Node Excision. Male. Mesentery / pathology. Middle Aged. Neoplasm Invasiveness. Pancreas / pathology. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 15770375.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Casaretto E, Andrada DG, Granero LE: [Results of cephalic pancreaticoduodenectomy for ampullary carcinoma. Analysis of 18 consecutive cases]. Acta Gastroenterol Latinoam; 2010 Mar;40(1):22-31
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  • [Title] [Results of cephalic pancreaticoduodenectomy for ampullary carcinoma. Analysis of 18 consecutive cases].
  • [Transliterated title] Resultados de la duodenopancreatectomía cefálica en el tratamiento del carcinoma de la ampolla de vater. Análisis de 18 casos consecutivos.
  • BACKGROUND: Complete resection offers the only potential cure for ampullary carcinoma.
  • AIM: The aim of this study was to assess the results of cephalic pancreaticoduodenectomy for patients with ampullary carcinoma based on mortality, hospital morbidity, late morbidity, and survival.
  • PATIENTS AND METHODS: We retrospectively and prospectively reviewed all patients who underwent cephalic pancreaticoduodenectomy, between October 1994 and October 2006 for ampullary carcinoma.
  • CONCLUSIONS: Cephalic pancreaticoduodenectomy is the surgical procedure of choice for ampullary carcinoma, with low hospital mortality, and the best chance for cure in patients with node-negative disease.
  • [MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prospective Studies. Retrospective Studies. Treatment Failure

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  • (PMID = 20446393.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Argentina
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38. Kim RD, Kundhal PS, McGilvray ID, Cattral MS, Taylor B, Langer B, Grant DR, Zogopoulos G, Shah SA, Greig PD, Gallinger S: Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma. J Am Coll Surg; 2006 Jan;202(1):112-9
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  • [Title] Predictors of failure after pancreaticoduodenectomy for ampullary carcinoma.
  • BACKGROUND: Complete resection offers the only potential cure for ampullary carcinoma.
  • We analyzed factors that contribute to treatment failure and survival in patients who underwent pancreaticoduodenectomy for ampullary carcinoma.
  • STUDY DESIGN: We retrospectively reviewed all patients who underwent pancreaticoduodenectomy between August 1994 and August 2003 for ampullary carcinoma.
  • CONCLUSIONS: Tumor stage is associated with treatment failure after pancreaticoduodenectomy for ampullary carcinoma and may identify candidates for adjuvant therapy.
  • Because an aggressive surgical approach can be adopted safely with the best chance for cure, we recommend that pancreaticoduodenectomy be offered to all patients with ampullary tumors when malignancy or dysplasia is in question.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 16377504.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Sommerville CA, Limongelli P, Pai M, Ahmad R, Stamp G, Habib NA, Williamson RC, Jiao LR: Survival analysis after pancreatic resection for ampullary and pancreatic head carcinoma: an analysis of clinicopathological factors. J Surg Oncol; 2009 Dec 15;100(8):651-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival analysis after pancreatic resection for ampullary and pancreatic head carcinoma: an analysis of clinicopathological factors.
  • BACKGROUND AND OBJECTIVES: Surgery remains the only curative option for the treatment of pancreatic and ampullary carcinomas.
  • To examine the survival differences between ampullary and pancreatic head carcinomas after pancreaticoduodenectomy.
  • METHODS: A retrospective review of patients with ampullary or pancreatic head adenocarcinoma undergoing curative resection during a 6-year period prior to 2000.
  • RESULTS: A total of 104 patients underwent pancreaticoduodenectomy for pancreatic head and ampullary carcinomas (n = 65 and n = 39, respectively).
  • Histologically, pancreatic cancer was worse, with more lymph node involvement and more positive resection margins and vascular and perineural invasions than found in ampullary carcinoma.
  • The median disease-free and overall survival rates were significantly better for ampullary cancer when compared with pancreatic cancer (17 vs. 9 months [P = 0.001] and 35 vs. 24 months [P = 0.006], respectively).
  • The actuarial 5-year disease-free and overall survival rates were 4.4% and 10.5%, respectively, for pancreatic carcinoma and 27.9% and 31.8%, respectively, for ampullary carcinoma.
  • Multivariate analysis showed that microscopic resection margin involvement (P = 0.02) and involvement of over three nodes (P < 0.001) were significant factors affecting the overall survival for pancreatic and ampullary carcinomas, respectively.
  • CONCLUSIONS: In this study, patients with ampullary carcinoma have a better prognosis and survival than those with pancreatic carcinoma.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19722229.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Voutsadakis IA, Doumas S, Tsapakidis K, Papagianni M, Papandreou CN: Bone and brain metastases from ampullary adenocarcinoma. World J Gastroenterol; 2009 Jun 7;15(21):2665-8
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  • [Title] Bone and brain metastases from ampullary adenocarcinoma.
  • Ampullary carcinoma is the second most common cancer of the peri-ampullary area after pancreatic carcinoma and metastasizes mostly intra-abdominally and to the liver.
  • In this report we describe the case of a patient with resected adenocarcinoma of the ampulla of Vater who developed skeletal metastases in the lower extremity and brain metastases.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Female. Humans. Middle Aged. Neoplasm Metastasis

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  • (PMID = 19496199.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2691500
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41. Yeh CC, Jeng YM, Ho CM, Hu RH, Chang HP, Tien YW: Survival after pancreaticoduodenectomy for ampullary cancer is not affected by age. World J Surg; 2010 Dec;34(12):2945-52
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  • [Title] Survival after pancreaticoduodenectomy for ampullary cancer is not affected by age.
  • BACKGROUND: Although pancreaticoduodenectomy (PD) provides the best chance of survival for elderly patients with ampullary carcinoma, it is associated with considerable surgical risk.
  • The aim of the present study was to compare the benefits and risks of pancreaticoduodenectomy as a treatment of ampullary carcinoma between young and elderly patients.
  • Comparison of the biological aggressiveness of ampullary cancer between old and younger patients was also performed by immunohistochemical study of several prognostic biological markers, including MUC1, MUC2, CK17, and CDX2.
  • RESULTS: For patients in whom ampullary carcinoma was presumed resectable preoperatively, actuarial survival was significantly poorer in 55 elderly patients because 9 of them did not have PD (the other 46 had PD) than in 101 younger patients (all had PD).
  • There were no significant differences in MUC1, CK17, MUC2, and CDX2 immunohistochemical staining of ampullary carcinomas between elderly and young patients.
  • CONCLUSIONS: Our data support the conclusion that ampullary cancers in elderly patients should be treated as aggressively as in younger patients.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / mortality

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  • (PMID = 20714897.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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42. Chen L, Tao SF, Zheng YX: Prognostic significance of vascular endothelial growth factor expression and microvessel density in carcinoma of ampulla of Vater. Hepatogastroenterology; 2006 Jan-Feb;53(67):45-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of vascular endothelial growth factor expression and microvessel density in carcinoma of ampulla of Vater.
  • BACKGROUND/AIMS: To investigate whether the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) are of prognostic significance in ampullary carcinoma.
  • METHODOLOGY: Twenty-two resected tumor specimens from patients with ampullary carcinoma were immunohistochemically stained for VEGF and CD34 (surrogate for vessels) by streptavidin-peroxidase method.
  • CONCLUSIONS: VEGF is positively correlated with MVD in ampullary carcinoma.
  • VEGF and angiogenesis may play an important role in lymph node metastasis and progression of ampullary carcinoma.
  • VEGF and MVD appear to be important prognostic predictor in patients with ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater. Carcinoma / blood supply. Carcinoma / metabolism. Common Bile Duct Neoplasms / blood supply. Common Bile Duct Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 16506374.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A
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43. Bel Hadj N, Elloumi H, Babba T, Kchaou-Oukaa A, Gargouri D, Kochlef A, Romani M, Kilani A, Kharrat J, Ghorbel A: [Carcinoma of the papilla of Vater. Diagnostic and therapeutic problems. An analysis of 32 Tunisian cases]. Tunis Med; 2006 Nov;84(11):701-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinoma of the papilla of Vater. Diagnostic and therapeutic problems. An analysis of 32 Tunisian cases].
  • [Transliterated title] Carcinome de l'ampoule de Vater: problémes diagnostiques et therapeutiques. Analyse d'une série de 32 patients.
  • The aim determine the clinical, morphological, endoscopical and progressive profile of patients with ampullary carcinoma.
  • PATIENTS AND METHODS: Thirty-two patients with a carcinoma of the ampulla of Vater, hospitalised in the Gastro-enterology service of Habib Thameur Hospital (Tunis) (1992-2002) have been analysed retrospectively.
  • Twelve patients (37%) had had a cholecystectomy into the 3 years preceding the diagnosis of the ampullary carcinoma.
  • After endoscopical sphincterectomy, an intra-ampullar exophytic tumour had been found in I case and an infiltrated aspect of the ampulla of Vater in 2 cases.
  • The use of lateral duodenoscopy allowed carrying the positive diagnosis in all cases.
  • Five patients had metastasis at the moment of diagnosis.
  • CONCLUSION: The ampullary carcinoma is a rare tumour diagnosed belated.
  • [MeSH-major] Ampulla of Vater. Carcinoma / diagnosis. Carcinoma / therapy. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / therapy

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  • (PMID = 17294894.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
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44. Giannopoulos G, Kavantzas N, Parasi A, Tiniakos D, Peros G, Tzanakis N, Patsouris E, Pavlakis K: Morphometric microvascular characteristics in the prognosis of pancreatic and ampullary carcinoma. Pancreas; 2007 Jul;35(1):47-52
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  • [Title] Morphometric microvascular characteristics in the prognosis of pancreatic and ampullary carcinoma.
  • OBJECTIVES: To evaluate multiple morphometric microvascular characteristics in addition to microvascular density (MVD) in pancreatic ductal and ampullary adenocarcinomas and provide a better approach in examining the relationship among angiogenesis, several clinicopathologic parameters, and prognosis.
  • METHODS: Histological sections from 32 pancreatic ductal and 17 ampullary adenocarcinomas, immunostained with CD34, were evaluated by image analysis for the quantification of MVD, total vascular area, and microvascular branching, as well as several morphometric parameters related to the vessel size and shape factor.
  • RESULTS: In pancreatic ductal carcinoma, higher levels of MVD, total vascular area, branching, and shape factor were related to N1 tumors.
  • In the ampullary carcinoma group, higher shape factor values were observed in well-differentiated tumors.
  • CONCLUSIONS: In pancreatic ductal carcinoma patients, the assessment of MVD and several morphometric microvascular characteristics provides significant prognostic information.
  • The biologic behavior of the ampullary carcinomas does not seem to be dependent on any of the above mentioned factors of angiogenesis.
  • [MeSH-major] Adenocarcinoma / blood supply. Adenocarcinoma / pathology. Carcinoma, Pancreatic Ductal / blood supply. Carcinoma, Pancreatic Ductal / pathology. Pancreatic Neoplasms / blood supply. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Ampulla of Vater / blood supply. Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Antigens, CD34 / metabolism. Female. Humans. Kaplan-Meier Estimate. Lymph Nodes / metabolism. Lymph Nodes / pathology. Male. Microcirculation / pathology. Multivariate Analysis. Neoplasm Staging. Neovascularization, Pathologic / pathology. Pancreas / blood supply. Pancreas / metabolism. Pancreas / pathology. Pancreatic Ducts / blood supply. Pancreatic Ducts / metabolism. Pancreatic Ducts / pathology. Prognosis

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  • (PMID = 17575545.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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45. Djurić-Stefanović A, Masulović D, Saranović Dj, Ivanović A, Stević R, Kostić J, Randić K, Mladenović M: [Computerized tomography in postoperative monitoring of patients with the Whipple operation--characteristics of CT findings]. Acta Chir Iugosl; 2009;56(4):107-11
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  • We presented the postoperative CT findings of patients after the Whipple's operation (cephalic pancreaticoduodenectomy), performed for the pancreatic head cancer, or ampullary carcinoma.
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Neoplasm Recurrence, Local / radiography. Postoperative Complications / radiography

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  • (PMID = 20420005.001).
  • [ISSN] 0354-950X
  • [Journal-full-title] Acta chirurgica Iugoslavica
  • [ISO-abbreviation] Acta Chir Iugosl
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Serbia
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46. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol; 2005 Mar;29(3):359-67
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  • [Title] Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
  • Pancreatobiliary and ampulla of Vater adenocarcinomas frequently metastasize to regional lymph nodes, liver, or lung and are difficult to diagnose because they lack specific immunohistochemical markers.
  • We studied the expression of cytokeratin 7 (CK7), cytokeratin 17 (CK17), cytokeratin 20 (CK20), CDX2, mucin 1 (MUC1), mucin 2 (MUC2), and mucin 5AC (MUC5AC) in 46 cases of pancreatic ductal carcinoma, 18 ampulla of Vater adenocarcinomas, and 24 intrahepatic cholangiocarcinomas.
  • The expression of MUC1 and CK17 was restricted to pancreatic ductal carcinoma (41 of 46, 89%; 38 of 46, 83%, respectively), the ampullary carcinoma of pancreatobiliary origin (6 of 6, 100%; 5 of 6, 83%, respectively), and intrahepatic cholangiocarcinoma (20 of 24, 83%; 17 of 24, 71%, respectively).
  • MUC2 was rarely expressed in pancreatic ductal carcinoma (1 of 46, 2%) and was negative in the ampullary carcinoma of pancreatobiliary origin and in intrahepatic cholangiocarcinoma.
  • A heterogeneous CDX2 staining pattern was seen in 1 of 6 cases of the ampullary carcinoma of pancreatobiliary origin (17%), 5 of 24 intrahepatic cholangiocarcinomas (21%), and 10 of 46 (22%) pancreatic ductal carcinomas.
  • We concluded that CK17 is a useful marker in separating pancreatobiliary adenocarcinomas from extra-pancreatobiliary nonmucinous adenocarcinomas, including adenocarcinomas from the colon, breast, gynecologic organs, stomach, lung, prostate, thyroid, kidney, and adrenal gland, and malignant mesothelioma.
  • MUC1+/CK17+ can be used as positive markers for pancreatic ductal carcinomas, the ampullary carcinoma of pancreatobiliary origin, and cholangiocarcinomas with positive predictive values of 76%, 83%, and 58%, respectively.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 15725805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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47. Perrone G, Morini S, Santini D, Rabitti C, Vincenzi B, Alloni R, Antinori A, Magistrelli P, Lai R, Cass C, Mackey JR, Coppola R, Tonini G, Onetti Muda A: Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes. Eur J Histochem; 2010;54(3):e38
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  • [Title] Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes.
  • The human equilibrative nucleoside transporter 1 (hENT1) is the major means by which gemcitabine enters human cells; recent evidence exists that hENT1 is expressed in carcinoma of the ampulla of Vater and that it should be considered as a molecular prognostic marker for patients with resected ampullary cancer.
  • Aim of the present study is to evaluate the variations of hENT1 expression in ampullary carcinomas and to correlate such variations with histological subtypes and clinicopathological parameters.
  • Forty-one ampullary carcinomas were histologically classified into intestinal, pancreaticobiliary and unusual types. hENT1 and Ki67 expression were evaluated by immunohistochemistry, and apoptotic cells were identified by the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate biotin nick end labelling (TUNEL) method. hENT1 overexpression was detected in 63.4% ampullary carcinomas.
  • Our results on hENT1 expression suggest that classification of ampullary carcinoma by morphological subtypes may represent an additional tool in prospective clinical trials aimed at examining treatment efficacy; in addition, data obtained from Ki67 and TUNEL suggest a key role of hENT1 in tumour growth of ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Carcinoma / metabolism. Equilibrative Nucleoside Transporter 1 / metabolism. Intestinal Neoplasms / metabolism. Pancreatic Neoplasms / metabolism

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  • (PMID = 20839414.001).
  • [ISSN] 2038-8306
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Equilibrative Nucleoside Transporter 1
  • [Other-IDs] NLM/ PMC3167316
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48. Tang W, Inagaki Y, Kokudo N, Guo Q, Seyama Y, Nakata M, Imamura H, Sano K, Sugawara Y, Makuuchi M: KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression. World J Gastroenterol; 2005 Sep 21;11(35):5450-4
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  • [Title] KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression.
  • AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.
  • METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection.
  • RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases.
  • Staining was not found in the surrounding non-cancer regions of the ampullary tissues.
  • Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes.
  • Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010).
  • CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Antigens / metabolism. Common Bile Duct Neoplasms / metabolism. Glycoproteins / metabolism. Mucins / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, Neoplasm. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin-1

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  • (PMID = 16222735.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens; 0 / Antigens, Neoplasm; 0 / Glycoproteins; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Mucins
  • [Other-IDs] NLM/ PMC4320352
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49. Abdullah SA, Gupta T, Jaafar KA, Chung YF, Ooi LL, Mesenas SJ: Ampullary carcinoma: effect of preoperative biliary drainage on surgical outcome. World J Gastroenterol; 2009 Jun 21;15(23):2908-12
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  • [Title] Ampullary carcinoma: effect of preoperative biliary drainage on surgical outcome.
  • AIM: To evaluate the influence of preoperative biliary drainage on morbidity and mortality after surgical resection for ampullary carcinoma.
  • METHODS: We analyzed retrospectively data for 82 patients who underwent potentially curative surgery for ampullary carcinoma between September 1993 and July 2007 at the Singapore General Hospital, a tertiary referral hospital.
  • Diagnosis of ampullary carcinoma was confirmed histologically.
  • The following parameters were analyzed: wound infection, intra-abdominal abscess, intra-abdominal or gastrointestinal bleeding, septicemia, biliary or pancreatic leakage, pancreatitis, gastroparesis, and re-operation rate.
  • However, the rest of the parameters did not differ significantly between the groups, i.e. sepsis [10 (28.6%) vs 14 (29.8%)], intra-abdominal bleeding [1 (2.9%) vs 5 (10.6%)], intra-abdominal abscess [1 (2.9%) vs 8 (17%)], gastrointestinal bleeding [3 (8.6%) vs 5 (10.6%)], pancreatic leakage [2 (5.7%) vs 3 (6.4%)], biliary leakage [2 (5.7%) vs 3 (6.4%)], pancreatitis [2 (5.7%) vs 2 (4.3%)], gastroparesis [6 (17.1%) vs 10 (21.3%)], need for blood transfusion [10 (28.6%) vs 17 (36.2%)] and re-operation rate [1 (2.9%) vs 5 (10.6%)].
  • CONCLUSION: Biliary drainage before surgery for ampullary cancer significantly reduced postoperative wound infection.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Drainage. Pancreatic Neoplasms / surgery. Preoperative Care

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  • (PMID = 19533815.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
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50. Wiedmann M, Schoppmeyer K, Witzigmann H, Hauss J, Mössner J, Caca K: [Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder]. Z Gastroenterol; 2005 Mar;43(3):305-15
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  • Carcinoma of the biliary tree are rare tumours of the gastrointestinal tract with a rising incidence during the last years.
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumour, middle and distal extrahepatic tumours), gallbladder cancer, and ampullary carcinoma.
  • Transformation of normal into malignant bile duct tissue requires a chain of consecutive gene mutations, similar to the adenoma-dysplasia-carcinoma-sequence in colon cancer.
  • Abdominal ultrasound, combined non-invasive magnetic resonance cholangiography/tomography (MRC/MRT), and facultatively endoscopic retrograde cholangiography (ERC) for unclear diagnosis, represent the gold standard for primary diagnosis.
  • For ampullary carcinoma, endosonography and endoscopic biopsy are the diagnostic tools of choice.
  • [MeSH-minor] Algorithms. Ampulla of Vater. Bile Ducts / pathology. Bile Ducts, Intrahepatic. Biopsy. Brachytherapy. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / therapy. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / therapy. Cyclooxygenase Inhibitors / therapeutic use. Gallbladder / pathology. Hepatectomy. Hepatic Duct, Common. Humans. Klatskin Tumor / diagnosis. Klatskin Tumor / therapy. Magnetic Resonance Imaging. Neoplasm Staging. Palliative Care. Retrospective Studies. Risk Factors. Stents. Time Factors

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  • [CommentIn] Z Gastroenterol. 2005 May;43(5):473-5 [15871071.001]
  • (PMID = 15765304.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors
  • [Number-of-references] 153
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51. Di Giorgio A, Alfieri S, Rotondi F, Prete F, Di Miceli D, Ridolfini MP, Rosa F, Covino M, Doglietto GB: Pancreatoduodenectomy for tumors of Vater's ampulla: report on 94 consecutive patients. World J Surg; 2005 Apr;29(4):513-8

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  • [Title] Pancreatoduodenectomy for tumors of Vater's ampulla: report on 94 consecutive patients.
  • Evaluation of prognostic factors of adenocarcinoma of Vater's ampulla is still a matter of debate.
  • The aim of this study was to evaluate retrospectively factors that influence early and long-term outcomes in a 20-year single-institution experience on ampullary carcinoma.
  • A total of 94 consecutive patients with ampullary carcinoma or adenoma with severe dysplasia were managed from 1981 to 2002.
  • Pancreatoduodenectomy is the treatment of choice for ampullary carcinoma and adenomas with high-grade dysplasia, with a good chance of long-term survival.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 15776300.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Perrone G, Santini D, Verzì A, Vincenzi B, Borzomati D, Vecchio F, Coppola R, Antinori A, Magistrelli P, Tonini G, Rabitti C: COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables. J Clin Pathol; 2006 May;59(5):492-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables.
  • To data, there have been few clinicopathological studies on COX-2 expression in human ampullary carcinoma and no data have been reported about its relation with tumour angiogenesis.
  • OBJECTIVE: To investigate by immunohistochemistry the expression of COX-2 and the angiogenesis process in a series of primary untreated ampullary carcinomas.
  • METHODS: Tissue samples from 40 archival ampullary carcinomas were analysed for COX-2, vascular endothelial growth factor (VEGF), and an endothelial cell marker von Willebrand factor (vWF) by immunohistochemistry, using specific antibodies.
  • CONCLUSIONS: COX-2 is highly expressed in ampullary carcinomas.
  • This suggests an involvement of the COX-2 pathway in ampullary tumour associated angiogenesis, providing a rationale for targeting COX-2 in the treatment of ampullary cancer.
  • [MeSH-major] Ampulla of Vater. Carcinoma / enzymology. Common Bile Duct Neoplasms / enzymology. Cyclooxygenase 2 / analysis. Neovascularization, Pathologic / etiology

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  • (PMID = 16489179.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Vascular Endothelial Growth Factor A; 0 / von Willebrand Factor; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ PMC1860297
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53. Chen JF, Chen WX, Wang XP, Li CX: [Differential diagnosis of pancreaticobiliary ductal and duodenal union carcinomas with MRI 3D-VIBE sequence combined with MRCP]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2009 Nov;40(6):1110-4, 1138
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  • [Title] [Differential diagnosis of pancreaticobiliary ductal and duodenal union carcinomas with MRI 3D-VIBE sequence combined with MRCP].
  • OBJECTIVE: To evaluate the value of MRI 3-dimensional volumetric interpolated breath-hold examination (VIBE) sequence combined with MR cholangiopancreatography (MRCP) in the differential diagnosis of pancreaticobiliary ductal and duodenal union carcinomas (PDDUC).
  • METHODS: Fifty nine patients with PDDUC confirmed by surgical-pathological findings or unequivocal clinical follow-up results were recruited in the study, which included 34 pancreatic head carcinomas, 14 distal common bile duct carcinomas, and 11 ampullary carcinomas.
  • The distance between the ends of the dilated pancreaticobiliary duct, the distance from the duodenal lumen to the distal end of the dilated duct, the diameter of the common bile duct and the pancreatic duct were measured.
  • The percentage of peripancreatic vascular involvement was significantly higher in the pancreatic head carcinoma than in the others.
  • The pancreaticobiliary conjunction angle, the distance between the ends of dilated pancreaticobiliary ducts, the distance from the duodenal lumen to the distal end of dilated duct were larger in the pancreatic head carcinoma than in the distal common bile duct carcinoma and ampullary carcinoma.
  • The pancreatic head carcinoma showed four-segment signs.
  • During portal venous phase, the mean SNR of the distal common bile duct carcinoma was higher than the pancreatic head carcinoma and ampullary carcinoma (P < 0.05), while in the other phases, no statistical significant differences were found (P > 0.05).
  • The signal intensity of distal common bile duct carcinoma was higher than the pancreatic head parenchyma during portal venous phase.
  • It is valuable in the differential diagnosis of pancreatic head carcinoma, distal common bile duct carcinoma and ampullary carcinoma.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Cholangiopancreatography, Magnetic Resonance / methods. Duodenal Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Pancreatic Ductal / pathology. Diagnosis, Differential. Female. Humans. Imaging, Three-Dimensional. Male. Middle Aged

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  • (PMID = 20067131.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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54. Park S, Kim SW, Lee BL, Jung EJ, Kim WH: Expression of E-cadherin and beta-catenin in the adenoma-carcinoma sequence of ampulla of Vater cancer. Hepatogastroenterology; 2006 Jan-Feb;53(67):28-32
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  • [Title] Expression of E-cadherin and beta-catenin in the adenoma-carcinoma sequence of ampulla of Vater cancer.
  • BACKGROUND/AIMS: Ampullary carcinoma is uncommon but provides a good model for adenoma-carcinoma sequence.
  • During the adenoma-carcinoma transition, the tumor cells should acquire the ability to invade.
  • METHODOLOGY: 111 cases of ampullary carcinoma were investigated with E-cadherin and beta-catenin expression with immunohistochemistry and the result was compared with their clinicopathologic and survival results.
  • RESULTS: Expressional loss of E-cadherin was detected in 3 (6.1%) adenomas and 73 (65.8%) carcinomas, and the expressional loss was significantly associated with tumor cell differentiation (p<0.05) and survival (p<0.05) in carcinoma.
  • CONCLUSIONS: Alteration of E-cadherin and beta-catenin is a late event during the adenoma-carcinoma sequence in ampullary neoplasms, and the loss of membranous expression of both E-cadherin and beta-catenin is closely correlated with less differentiated histology and poor prognosis.
  • [MeSH-major] Adenoma / metabolism. Adenoma / pathology. Ampulla of Vater. Cadherins / biosynthesis. Carcinoma / metabolism. Carcinoma / pathology. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology. beta Catenin / biosynthesis

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  • (PMID = 16506371.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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55. Katsinelos P, Kountouras J, Chatzimavroudis G, Zavos C, Paroutoglou G, Kotakidou R, Panagiotopoulou K, Papaziogas B: A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection. Surg Laparosc Endosc Percutan Tech; 2007 Dec;17(6):533-7

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  • [Title] A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection.
  • A 72-year-old man, with known prostate cancer, was admitted to our endoscopic unit for further evaluation of an obstruction at major papilla level.
  • Endoscopic cholangiopancreatography revealed a depressed-type carcinoma at the ampulla of Vater and dilation of both the common bile and pancreatic ducts without intraductal filling defects.
  • Intraductal ultrasonography showed a hypoechoic mass limited to the ampulla of Vater.
  • Histologic examination of the resected specimen showed a completely excised well-differentiated adenocarcinoma limited to the ampulla of Vater.
  • Both accurate preoperative staging and proper histologic evaluation of the resected specimen seem to justify endoscopic treatment of early ampullary cancer by an experienced endoscopist.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Endosonography. Humans. Male. Neoplasm Staging. Treatment Outcome

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  • (PMID = 18097317.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Liu N, Liang H, Zhang RP, Pan Y, Liu Y, Deng JY, Wang XN, Ding XW, Hao XS: [Number of lymph node metastases: a significant prognostic factor for patients with radical resection of carcinoma of the ampulla of Vater]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Jul;10(4):350-2
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  • [Title] [Number of lymph node metastases: a significant prognostic factor for patients with radical resection of carcinoma of the ampulla of Vater].
  • OBJECTIVE: To identify prognostic factors predicting survival after radical resection of ampullary carcinoma.
  • METHODS: Clinical data of sixty- five patients with cancer of the ampulla of Vater underwent pancreaticoduodenectomy and regional lymphadenectomy were analyzed retrospectively.
  • CONCLUSION: The number of positive regional lymph nodes is an independent prognostic factor in patients with ampullary carcinoma after resection.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / diagnosis. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma / pathology. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Prognosis. Retrospective Studies

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  • (PMID = 17659460.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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57. Tonini G, Virzì V, Fratto ME, Vincenzi B, Santini D: Targeted therapy in biliary tract cancer: 2009 update. Future Oncol; 2009 Dec;5(10):1675-84
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  • [Title] Targeted therapy in biliary tract cancer: 2009 update.
  • Biliary tract cancers (BTCs) include cholangiocarcinoma (intrahepatic, perihilar and extrahepatic), carcinoma of the gall bladder and ampullary carcinoma.

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  • (PMID = 20001803.001).
  • [ISSN] 1744-8301
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 78
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58. Khaimook A, Borkird J, Alapach S: The first successful laparoscopic Whipple procedure at Hat Yai Hospital: surgical technique and a case report. J Med Assoc Thai; 2010 Sep;93(9):1098-102

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  • Whipple procedure is the most complex abdominal surgical procedure to treat periampullary carcinoma.
  • The patient was a 40-year-old, Thai-Muslim female, with the diagnosis of ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Laparoscopy / methods. Pancreaticoduodenectomy / methods

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  • (PMID = 20873085.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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59. Nielsen A, Scarlett CJ, Samra JS, Gill A, Li Y, Allen BJ, Smith RC: Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction. J Gastroenterol Hepatol; 2005 Feb;20(2):256-63
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  • [Title] Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction.
  • It was hypothesized that uPA would be overexpressed in highly metastatic pancreatic cancer.
  • The aims of this study were to analyze uPA mRNA expression in pancreatic cancer and to correlate this to the expression of uPA protein and to the stage of the disease.
  • METHODS: Twenty-one pancreatic adenocarcinoma, six ampullary carcinoma and 10 benign mucinous cystadenoma samples, all with adjacent normal tissue, were collected. uPA mRNA was measured using real-time quantitative reverse transcription polymerase chain reaction.
  • Localization of uPA within normal and pancreatic tumor sections was subsequently confirmed using immunohistochemistry.
  • RESULTS: The median and range of the ratios of uPA mRNA measures between tumor tissue and non-involved pancreatic tissue was 17.1 (1.4-653.6) for pancreatic adenocarcinoma (P < 0.001), 3.9 (0.7-7.7) for ampullary carcinoma (P = 0.055) and 1.9 (0.6-5.9) for mucinous cystadenoma tissue (P = 0.052).
  • Immunohistochemistry confirmed that uPA protein was more prevalent in pancreatic adenocarcinoma tissue than in normal tissue and that it was membrane-bound. uPA mRNA expression was significantly associated with poorly differentiated pancreatic cancers (P < 0.05) and positively associated with tumor stage.
  • CONCLUSIONS: These observations suggest that significant overexpression of uPA correlates closely to the rapid progression and invasiveness of pancreatic cancer and that uPA may provide a future therapeutic target for pancreatic cancer treatment.
  • [MeSH-major] Adenocarcinoma / genetics. Pancreatic Neoplasms / genetics. Urokinase-Type Plasminogen Activator / genetics

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  • [Copyright] (c) 2004 Blackwell Publishing Asia Pty Ltd.
  • (PMID = 15683429.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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60. Ridwelski K, Meyer F, Schmidt U, Lippert H: [Results of surgical treatment in ampullary and pancreatic carcinoma and its prognostic parameters after R0-resection]. Zentralbl Chir; 2005 Aug;130(4):353-61
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  • [Title] [Results of surgical treatment in ampullary and pancreatic carcinoma and its prognostic parameters after R0-resection].
  • INTRODUCTION: Resection is currently the only established reasonable therapeutic option with curative potential in pancreatic and ampullary carcinoma.
  • METHODS: Two-hundred-twenty patients with pancreatic and ampullary carcinoma (mean age, 61.4 years; 104 females/116 males) underwent surgery.
  • Histologic investigation revealed 19 carcinomas of the papilla of Vater and 201 ductal pancreatic carcinomas.
  • RESULTS: Hundred-ten patients underwent tumor resection with primary curative intention (50 %): 96 resections of the pancreatic head, 2 total pancreatectomies and 12 left resections of the pancreas.
  • Postoperative letality of curative pancreatic resections was 3.6 % (palliative intervention, 6.7 %; explorative laparotomy, 8.8 %).
  • Five-year survival-rate of carcinoma of the papilla of Vater and pancreatic carcinoma was 73.3 % and 16.2 %, respectively (median survival time was 66.0 and 14.0 months, respectively).
  • CONCLUSION: Resection of pancreatic and ampullary carcinoma according to oncological criteria with tumor-free margins can be considered a treatment option with curative intention and potential.
  • The 5-year survival-rate of 16.2 % in ductal pancreatic carcinoma underlines the demand for the development of effective multimodal therapeutic concepts.
  • Such interventions in patients with pancreatic carcinoma are no reasonable treatment alternative.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Pancreatic Ductal / surgery. Common Bile Duct Neoplasms / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Female. Gastroenterostomy. Humans. Male. Middle Aged. Neoplasm Staging. Pancreas / pathology. Postoperative Complications. Prognosis. Survival Analysis. Time Factors

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  • (PMID = 16103961.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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61. Brown KM, Tompkins AJ, Yong S, Aranha GV, Shoup M: Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer. Arch Surg; 2005 Jun;140(6):529-32; discussion 532-3

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  • [Title] Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer.
  • HYPOTHESIS: Survival following resection for ampullary carcinoma may be influenced by 1 or more clinical or pathologic variables.
  • PATIENTS: From July 1, 1991, through April 30, 2004, 72 patients (31 males and 41 females) were treated for ampullary carcinoma at Loyola University Medical Center, Maywood, Ill.
  • INTERVENTIONS: Whipple procedure for attempted cure in 51 patients with ampullary adenocarcinoma.
  • CONCLUSION: Pancreaticoduodenectomy is curative in 80% of patients with node-negative ampullary carcinomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater. Blood Loss, Surgical. Female. Humans. Lymph Nodes / pathology. Male. Middle Aged. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome

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  • [CommentIn] Arch Surg. 2005 Jul;140(7):708 [16027340.001]
  • (PMID = 15967899.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Kim YK, Han YM, Kim CS: Usefulness of fat-suppressed T1-weighted MRI using orally administered superparamagnetic iron oxide for revealing ampullary carcinomas. J Comput Assist Tomogr; 2007 Jul-Aug;31(4):519-25
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  • [Title] Usefulness of fat-suppressed T1-weighted MRI using orally administered superparamagnetic iron oxide for revealing ampullary carcinomas.
  • OBJECTIVE: To evaluate the value of adding fat-suppressed (FS) T1-weighted magnetic resonance imaging (MRI) with orally administered superparamagnetic iron oxide (SPIO) to the 3-dimensional dynamic MRI for revealing ampullary carcinomas.
  • MATERIALS: Twenty-five patients with ampullary carcinoma who underwent MRI with orally administered SPIO, including a FS T1-weighted fast low-angle shot (FLASH) sequence, a respiratory-triggered turbo spin-echo (RT-TSE) sequence, and the 3-phasic 3-dimensional dynamic images, were enrolled in this study.
  • CONCLUSIONS: Addition of the FS FLASH image using orally administered SPIO to the dynamic MRI is useful for revealing ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Contrast Media. Ferric Compounds. Image Enhancement / methods. Magnetic Resonance Imaging / methods

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  • (PMID = 17882025.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
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63. Chung YE, Kim MJ, Park MS, Choi JY, Kim H, Kim SK, Lee M, Kim HJ, Choi JS, Song SY, Kim KW: Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging. Radiology; 2010 Nov;257(2):384-93
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  • [Title] Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging.
  • PURPOSE: To define the differential imaging features of pancreatobiliary- and intestinal-type ampullary carcinomas at magnetic resonance (MR) imaging and to correlate these features with pathologic findings.
  • Fifty patients with surgically confirmed ampullary carcinoma and preoperative MR results were included.
  • Two radiologists, blinded to histologic type of cancer, evaluated imaging findings in consensus.
  • Intestinal carcinoma commonly manifested with an oval filling defect at the distal end of the bile duct on MR cholangiopancreatographic (MRCP) images (11 [73%] of 15 vs four [11%] of 35 in pancreatobiliary type) (P < .001).
  • At endoscopy, intestinal carcinoma manifested with an extramural protruding mass (n = 15, 100%) with a papillary surface (n = 11, 73%), whereas pancreatobiliary carcinoma manifested with intramural protruding (n = 5, 28%) or ulcerating (n = 1, 6%) gross morphologic features (P = .047) with a nonpapillary surface (n = 17, 94%) (P < .001).
  • Multiple logistic regression analysis showed that an oval filling defect at the distal end of the bile duct was the only independent finding for differentiating intestinal from pancreatobiliary carcinoma (P = .027).
  • CONCLUSION: An oval filling defect at the distal end of the bile duct on MRCP images and an extramural protruding appearance with a papillary surface at endoscopy are likely to suggest intestinal ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiopancreatography, Magnetic Resonance / methods. Common Bile Duct Neoplasms / diagnosis. Duodenal Neoplasms / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Diagnosis, Differential. Female. Humans. Image Interpretation, Computer-Assisted. Immunohistochemistry. Logistic Models. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate

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  • [Copyright] © RSNA, 2010.
  • (PMID = 20829529.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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64. Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, Furuse J, Saito H, Tsuyuguchi T, Yamamoto M, Kayahara M, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Hirano S, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg; 2008;15(1):41-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment.
  • The only curative treatment in biliary tract cancer is surgical treatment.
  • Although hepatectomy and/or pancreaticoduodenectomy are preferable for the curative resection of bile duct cancer, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict diagnosis of its local extension.
  • Prognostic factors after resection for bile duct cancer include positive surgical margins, especially in the ductal stump; lymph node metastasis; perineural invasion; and combined vascular resection due to portal vein and/or hepatic artery invasion.
  • For patients with suspected gallbladder cancer, laparoscopic cholecystectomy is not recommended, and open cholecystectomy should be performed as a rule.
  • When gallbladder cancer invading the subserosal layer or deeper has been detected after simple cholecystectomy, additional resection should be considered.
  • Prognostic factors after resection for gallbladder cancer include the depth of mural invasion; lymph node metastasis; extramural extension, especially into the hepatoduodenal ligament; perineural invasion; and the degree of curability.
  • Pancreaticoduodenectomy is indicated for ampullary carcinoma, and limited operation is also indicated for carcinoma in adenoma.
  • The prognostic factors after resection for ampullary carcinoma include lymph node metastasis, pancreatic invasion, and perineural invasion.
  • [MeSH-major] Ampulla of Vater / surgery. Biliary Tract Neoplasms / surgery. Carcinoma / surgery
  • [MeSH-minor] Biliary Tract / pathology. Biliary Tract Surgical Procedures / methods. Evidence-Based Medicine / methods. Humans. Neoplasm Staging. Preoperative Care / methods. Survival Rate

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  • (PMID = 18274843.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794356
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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65. Ney JT, Zhou H, Sipos B, Büttner R, Chen X, Klöppel G, Gütgemann I: Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts. Hum Pathol; 2007 Feb;38(2):359-64
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  • [Title] Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts.
  • So far, no specific marker for pancreatic ductal adenocarcinomas has been described.
  • We found that 44% (71/160) of pancreatic ductal adenocarcinomas expressed PODXL-1 in a membranous pattern.
  • When used as a differential diagnostic marker, ampullary carcinoma needs to be excluded, as 30% (6/20, P = .24) of ampullary carcinomas stain positive, especially those of the signet-ring type (3/3).
  • It is concluded that immunoreactivity for PODXL-1 favors a pancreatic origin if ampullary carcinoma is excluded.
  • [MeSH-major] Adenocarcinoma / secondary. Biliary Tract Neoplasms / pathology. Carcinoma, Pancreatic Ductal / pathology. Gastrointestinal Neoplasms / pathology. Pancreatic Neoplasms / secondary. Sialoglycoproteins / analysis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biomarkers, Tumor / metabolism. Blotting, Western. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male

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  • (PMID = 17137615.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Sialoglycoproteins; 0 / podocalyxin
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66. Popescu I, David L, Dumitra AM, Dorobantu B: The posterior approach in pancreaticoduodenectomy: preliminary results. Hepatogastroenterology; 2007 Apr-May;54(75):921-6
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  • BACKGROUND/AIMS: We present our technical version of pancreaticoduodenectomy by posterior approach that enables a complete dissection of the right side of the mesenteric superior artery and of the portal vein, as well as a complete excision of the retroportal pancreatic process (or lamina), and report the preliminary outcomes of the first 10 selected patients.
  • The patients were diagnosed with carcinoma of the pancreatic head (8 cases), ampullary carcinoma (1 case), and carcinoma of the distal part of the common bile duct (1 case).
  • Invasion of the portal vein occurred in 2 of the 8 cases of carcinoma of the pancreatic head.
  • Two cases of carcinoma of the pancreatic head that had a segmental resection of the portal vein needed vascular reconstruction which was performed by Goretex graft interpositing.
  • The pylorus-preserving procedure was used in 2 cases (ampullary carcinoma, and carcinoma of the distal part of the common bile duct, respectively).
  • Postoperative complications consisted of intraabdominal hemorrhage from an arterial source of the pancreatic capsule (on the day of the operation necessitating reoperation for hemostasis) in one case, and pancreatic fistula (that required conservative treatment) in another case.
  • [MeSH-major] Carcinoma / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Postoperative Complications / diagnosis. Treatment Outcome

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  • (PMID = 17591093.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Greece
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67. Dittrick GW, Mallat DB, Lamont JP: Management of ampullary lesions. Curr Treat Options Gastroenterol; 2006 Sep;9(5):371-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of ampullary lesions.
  • Adenomatous lesions of the ampulla of Vater are relatively rare neoplasms that raise many questions regarding standard management.
  • Adenocarcinoma often will be found in ampullary lesions and should be treated by pancreaticoduodenectomy (PD).
  • Preoperative endoscopic biopsies should be obtained to identify carcinoma, but they have high false-negative rates and cannot be relied upon to rule out malignancy.
  • Intraoperative frozen section evaluation should be requested routinely during AMP, with conversion to PD if carcinoma is demonstrated.
  • Adjuvant chemoradiation has a very limited role in the treatment of ampullary carcinoma and ideally should be offered in the setting of a clinical trial.

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  • (PMID = 16942661.001).
  • [ISSN] 1092-8472
  • [Journal-full-title] Current treatment options in gastroenterology
  • [ISO-abbreviation] Curr Treat Options Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Cortes A, Sauvanet A, Bert F, Janny S, Sockeel P, Kianmanesh R, Ponsot P, Ruszniewski P, Belghiti J: Effect of bile contamination on immediate outcomes after pancreaticoduodenectomy for tumor. J Am Coll Surg; 2006 Jan;202(1):93-9
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  • RESULTS: The distribution of tumors was comparable except for ampullary carcinoma, which was more frequent in group B+ patients (p = 0.001).
  • During PD for ampullary carcinoma or after interventional biliary endoscopy, a specific antibioprophylaxis should be evaluated.
  • [MeSH-major] Ampulla of Vater. Bile / microbiology. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications

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  • (PMID = 16377502.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Bloomston M, Ellison EC, Muscarella P, Al-Saif O, Martin EW, Melvin WS, Frankel WL: Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer. Ann Surg Oncol; 2007 Jan;14(1):211-7
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  • [Title] Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer.
  • BACKGROUND: Osteonectin has been suggested to be important in the progression of pancreatic cancer but has not been correlated with survival.
  • We determined the osteonectin expression and its influence on survival in patients with ampullary carcinoma.
  • METHODS: Tissue microarrays were constructed from the tumors of 56 patients with ampullary cancer undergoing pancreaticoduodenectomy.
  • Median follow-up for all living patients with ampullary cancer was 69.6 months.
  • RESULTS: Osteonectin was significantly (P < .05, Fisher's exact test) overexpressed in the stroma of ampullary cancers (90%) relative to chronic pancreatitis (62%) and normal pancreas (0%).
  • CONCLUSIONS: Although the importance of tumor-stroma interactions in periampullary cancers is not fully understood, our data suggest that osteonectin is an integral stromal element in ampullary cancers, and its overexpression is associated with decreased survival.
  • [MeSH-major] Adenocarcinoma / chemistry. Ampulla of Vater. Biomarkers, Tumor / analysis. Common Bile Duct Neoplasms / chemistry. Osteonectin / analysis

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  • (PMID = 17080236.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Osteonectin; 106441-73-0 / Osteopontin
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70. Hosaka A, Nagayoshi M, Sugizaki K, Masaki Y: Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report. World J Surg Oncol; 2010;8:41
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  • [Title] Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report.
  • A tumor of the ampulla of Vater causes gradually progressive symptoms, and is rarely associated with perforation of the gallbladder.
  • CASE PRESENTATION: A 56-year-old man with carcinoma of the ampulla of Vater presented with spontaneous gallbladder perforation and localized bile peritonitis.
  • Postoperative upper gastrointestinal endoscopy demonstrated a slightly enlarged duodenal papilla, and biopsy revealed adenocarcinoma of the ampulla.
  • CONCLUSION: Ampullary carcinoma can be associated with gallbladder perforation and present with acute manifestations.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Gallbladder / pathology. Gallbladder Diseases / diagnosis
  • [MeSH-minor] Abdominal Pain. Humans. Male. Middle Aged. Pancreaticoduodenectomy. Peritonitis / diagnosis. Rupture, Spontaneous. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20487525.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2887867
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71. Barauskas G, Gulbinas A, Pranys D, Dambrauskas Z, Pundzius J: Tumor-related factors and patient's age influence survival after resection for ampullary adenocarcinoma. J Hepatobiliary Pancreat Surg; 2008;15(4):423-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-related factors and patient's age influence survival after resection for ampullary adenocarcinoma.
  • BACKGROUND/PURPOSE: The majority of surgeons agree that ampullary adenocarcinoma should be removed by partial pancreatoduodenectomy.
  • Favoring extended resection, based on the uncertainty of the preoperative diagnosis and the higher probability of clear resection margins, we aimed to disclose the results of this surgical procedure in terms of postoperative morbidity and mortality, and to identify prognosticators of long-term survival.
  • METHODS: We documented, prospectively, 25 consecutive patients with adenocarcinoma of the papilla of Vater in whom pylorus-preserving pancreatoduodenectomy was performed.
  • Clinical data, pathology reports, International Union Against Cancer (UICC) tumor stage, postoperative morbidity, mortality, and long-term follow-up results were evaluated.
  • CONCLUSIONS: Pancreatoduodenectomy for ampullary carcinoma is reasonable in terms of postoperative morbidity and mortality.
  • [MeSH-major] Adenocarcinoma / mortality. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Pancreaticoduodenectomy

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  • (PMID = 18670845.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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72. Dai YC, Ho CL, Tsai YC, Hsu YH, Chang YC, Liu HS, Chen HH, Chow NH: Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval. J Cancer Res Clin Oncol; 2005 Feb;131(2):94-100
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval.
  • PURPOSE: The genetic basis for gastrointestinal and ampullary carcinomas remains uncertain.
  • METHODS: We screened the allelic status on 16 chromosomal arms in a patient with synchronous ampullary carcinoma and gastric cancer, but who had no family history of familial cancer syndrome.
  • The significance of the shared 14q deletion was examined on clinical cohorts of sporadic gastric (n=12) and ampullary (n=10) carcinoma, respectively.
  • RESULTS: The synchronous gastric and ampullary carcinomas had no frameshift mutations in the APC, MSH2, MSH3, and MSH6 genes.
  • The same allelic loss was also detected in one of ampullary carcinomas (10%) and two of gastric cancers (16.7%).
  • CONCLUSIONS: This study illustrates a paradigm using molecular genetic approach in identifying chromosome 14q32 that may harbor a tumor suppressor gene involved in the pathogenesis of a subset of gastrointestinal and ampullary malignancies.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma / genetics. Chromosomes, Human, Pair 14 / genetics. Common Bile Duct Neoplasms / genetics. Genetic Predisposition to Disease. Loss of Heterozygosity / genetics. Stomach Neoplasms / genetics

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  • (PMID = 15503134.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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73. Carter RR, Woodall CE 3rd, McNally ME, Talboy GE, Lankachandra KM, Van Way CW 3rd: Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors. Am Surg; 2008 Apr;74(4):338-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed ductal-endocrine carcinoma of the pancreas with synchronous papillary carcinoma-in-situ of the common bile duct: a case report and literature review--synchronous pancreatic and bile duct tumors.
  • This report is a case of a 58-year-old woman with a mixed ductal-endocrine carcinoma of the pancreas and a synchronous carcinoma-in-situ of the common bile duct.
  • Endoscopic retrograde cholangiopancreatography revealed an ulcerated lesion of the ampulla.
  • Subsequently, pancreatoduodenectomy was performed for the diagnosis of peri-ampullary carcinoma.
  • On histopathological examination, it was discovered that this lesion contained two separate neoplasms: papillary carcinoma-in-situ of the intraparenchymal portion of the common bile duct and a mixed ductal-endocrine carcinoma of the pancreas.
  • Mixed ductal-endocrine carcinoma of the pancreas is very rare.
  • Finding it in conjunction with a synchronous, overlying papillary carcinoma carcinoma-in-situ of the common bile duct has not been previously described.
  • [MeSH-major] Carcinoma in Situ / pathology. Carcinoma, Pancreatic Ductal / pathology. Common Bile Duct Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 18453301.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 8
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74. Peng SY, Hong DF, Liu YB, Tan ZJ, Li JT, Tao F: [Binding pancreaticogastrostomy]. Zhonghua Wai Ke Za Zhi; 2009 Jan 15;47(2):139-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: From May 2008 to October 2008, 15 patients were performed with BPG, included pancreatic head cancer in 7 cases, duodenal adenocarcinoma in 2 cases,mass-type chronic pancreatitis with pancreatolithiasis in 1 case, ampullary carcinoma in 1 case, gallbladder cancer in 1 case, islet cell tumor in 1 case and cholangiocarcinoma in 2 cases.

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  • (PMID = 19563012.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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75. Furuse J, Okusaka T, Miyazaki M, Taniai H, Nimura Y, BT22 Study Group: A randomized study of gemcitabine/cisplatin versus single-agent gemcitabine in patients with biliary tract cancer. J Clin Oncol; 2009 May 20;27(15_suppl):4579

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A randomized study of gemcitabine/cisplatin versus single-agent gemcitabine in patients with biliary tract cancer.
  • RESULTS: A total of 83 pts (19 extrahepatic bile duct cancer, 28 intrahepatic bile duct cancer, 32 gallbladder cancer and 4 ampullary carcinoma) were eligible for the study protocol defined analysis set (Full Analysis Set, FAS); GC-arm n=41 and G-arm n=42.

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  • (PMID = 27963070.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Gooszen H: [Carcinoma of the head of the pancreas: indication for emergency surgery]. Ned Tijdschr Geneeskd; 2010;154:A2148
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Carcinoma of the head of the pancreas: indication for emergency surgery].
  • In a recent multicentre randomized clinical trial, Van der Gaag et al. randomly assigned 220 patients to early surgery or preoperative biliary drainage ('Preoperative drainage for cancer of the head of the pancreas').
  • If forthcoming publications by this research group confirm this suggestion, the current paradigm - obstructive jaundice, endoscopic retrograde cholangiopancreatography with stenting, delayed surgery for carcinoma of the head of the pancreas - should be changed to: obstructive jaundice due to peri-ampullary carcinoma should be considered an indication for emergency surgery.
  • [MeSH-major] Carcinoma / surgery. Drainage / adverse effects. Pancreatic Neoplasms / surgery. Postoperative Complications / epidemiology. Preoperative Care

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  • [CommentOn] Ned Tijdschr Geneeskd. 2010;154(29):A1883 [20699038.001]
  • (PMID = 20699039.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article; Comment
  • [Publication-country] Netherlands
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77. Fujita N, Noda Y, Kobayashi G, Ito K, Obana T, Horaguchi J, Takasawa O, Nakahara K: Histological changes at an endosonography-guided biliary drainage site: a case report. World J Gastroenterol; 2007 Nov 7;13(41):5512-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We performed ESBD 14 d preoperatively in a patient with an ampullary carcinoma and histologically confirmed changes in and around the fistula.
  • [MeSH-major] Ampulla of Vater / surgery. Biliary Tract Surgical Procedures / methods. Cholestasis / complications. Common Bile Duct Neoplasms / surgery. Drainage. Endosonography. Jaundice, Obstructive / etiology

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  • (PMID = 17907298.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4171289
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78. Wu LH, Zhang W: [Prevention and treatment of complications after duodenopancreatectomy]. Di Yi Jun Yi Da Xue Xue Bao; 2005 Apr;25(4):461-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The clinical data of 36 cases receiving duodenopancreatectomy during the last decade were analyzed, including 13 cases of ampullary carcinoma, 8 cases of carcinoma of the pancreas head, 8 cases of distal cholangiocarcinoma, and 7 cases of carcinoma of the duodenal papilla.
  • RESULTS: Complications occurred in 6 cases after duodenopancreatectomy including pancreatic fistula in 3 cases, bile duct fistula in 1 case, abdominal cavity hemorrhage in 1 case, and alimentary tract hemorrhage in 1 case, with an incidence rate of postoperative complications of 16.7%; and death occurred in 2 cases.
  • CONCLUSION: Adequate measures should be taken to reduce such complications as pancreatic fistula, bile duct fistula, abdominal cavity hemorrhage, alimentary tract hemorrhage and abdominal cavity infection, and these measures include nutritional support, careful operation in the surgery with adequate drainage, and careful observation and nursing after the surgery.
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / adverse effects. Postoperative Complications / prevention & control
  • [MeSH-minor] Adult. Aged. China / epidemiology. Common Bile Duct Neoplasms / surgery. Female. Humans. Male. Middle Aged. Pancreatic Fistula / epidemiology. Pancreatic Fistula / etiology. Pancreatic Fistula / prevention & control

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  • (PMID = 15837657.001).
  • [ISSN] 1000-2588
  • [Journal-full-title] Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
  • [ISO-abbreviation] Di Yi Jun Yi Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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79. Santini D, Vincenzi B, Tonini G, Scarpa S, Vasaturo F, Malacrino C, Vecchio F, Borzomati D, Valeri S, Coppola R, Magistrelli P, Nuzzo G, Picciocchi A: Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. Clin Cancer Res; 2005 May 15;11(10):3784-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients.
  • PURPOSE: To identify potential prognostic molecular factors in ampullary adenocarcinoma that could be of significant importance.
  • To this end, we examined the possible prognostic significance of cyclooxygenase-2 (Cox-2) and Survivin expression and the apoptotic index in a cohort of uniformly treated patients with ampullary cancer treated with radical surgical excision.
  • EXPERIMENTAL DESIGN: The entry criteria were that the patients have a pathologic diagnosis of ampullary cancer which had been resected.
  • RESULTS: Thirty-nine tumor specimens from resected ampullary adenocarcinoma patients were included.
  • CONCLUSIONS: The results of the present article provide, for the first time, evidence that Cox-2 expression, but not Survivin expression, may represent a significant prognostic factor after surgical resection in patients affected by cancer of the ampulla of Vater.
  • Further studies are required to determine whether Cox-2 inhibitors may be useful for the therapy or prevention of ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / genetics. Common Bile Duct Neoplasms / pathology. Gene Expression Profiling. Prostaglandin-Endoperoxide Synthases / biosynthesis. Prostaglandin-Endoperoxide Synthases / genetics
  • [MeSH-minor] Adult. Aged. Apoptosis. Cyclooxygenase 2. Female. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Male. Membrane Proteins. Microtubule-Associated Proteins / biosynthesis. Microtubule-Associated Proteins / genetics. Middle Aged. Neoplasm Proteins. Predictive Value of Tests. Prognosis

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  • (PMID = 15897577.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Membrane Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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80. Qiao QL, Zhao YG, Ye ML, Yang YM, Zhao JX, Huang YT, Wan YL: Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection. World J Surg; 2007 Jan;31(1):137-43; discussion 144-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection.
  • INTRODUCTION: The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms.
  • Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected.
  • The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected ampullary carcinoma.
  • METHODS: Clinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002.
  • Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).
  • CONCLUSIONS: Carcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Hospital Mortality. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 17171495.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Yao HS, Wang Q, Wang WJ, Hu ZQ: Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis. World J Surg; 2008 Sep;32(9):2038-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis.
  • BACKGROUND: Allogeneic blood transfusion (ABT) containing packed red blood cells (RBCs) has a known immunosuppressive effect that may affect cancer metastases and recurrence.
  • This study examined whether intraoperative allogeneic RBC transfusion is an independent risk factor of adverse outcome in patients with ampullary carcinoma after curative pancreatoduodenectomy.
  • METHODS: The clinical data of 67 patients with carcinoma of the ampulla of Vatar underwent pancreatoduodenectomy between 1999 and 2004 were analyzed, and long-term follow-up visits were made for all patients.
  • For the meta-analysis, all English-language studies regarding blood transfusion from carcinoma of the ampulla of Vatar or ampullary carcinoma and prognostic factors or factors for survival from 1995 to 2007 were reviewed, and contingency tables were constructed from which a summary relative risk was calculated.
  • After multivariate analysis, except for presence of lymph node metastasis (P = 0.023) and pancreatic invasion (P = 0.024), the intraoperative ABT > or =3 units was found to be an independent poor prognostic factor for those with ampullary cancer after curative pancreatoduodenectomy either (relative risk, 2.082; 95% confidence interval (CI), 1.048-4.135; P = 0.036).
  • CONCLUSIONS: The amount of intraoperative ABT is one of the important factors that adversely influenced survival in patients with ampullary cancer after curative pancreatoduodenectomy.
  • [MeSH-major] Ampulla of Vater / surgery. Erythrocyte Transfusion. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Blood Loss, Surgical. Blood Transfusion, Autologous. Chi-Square Distribution. Female. Humans. Intraoperative Care. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models. Risk Factors. Survival Analysis. Treatment Outcome

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  • (PMID = 18584239.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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82. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Signet-ring cell carcinoma of the ampulla of Vater: report of a case. Surg Today; 2007;37(12):1110-4
Genetic Alliance. consumer health - Signet ring cell carcinoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Signet-ring cell carcinoma of the ampulla of Vater: report of a case.
  • Signet-ring cell carcinoma (SRCC) of the ampulla of Vater is uncommon, and only 13 cases have been previously described.
  • We herein report a rare case of a 43-year-old woman with SRCC in the ampulla of Vater.
  • Although this histologic type of cancer generally predicts a poor prognosis elsewhere in the gastrointestinal tract, the present patient has survived with no evidence of recurrence for 7.5 years.
  • She underwent a pancreaticoduodenectomy with an extended lymphadenectomy for ampullary carcinoma.
  • This neoplasm was classified as AcdbBi, 2.0 x 1.8 cm, ulcerative type, Panc(0), Du(2), T(2)N(0)M(-), Stage II according to the Japanese Classification on Cancer of the Biliary Tract.
  • Unfortunately, previous reports of ampullary SRCC have been limited to short-term follow-ups with a median period of only 12 months (range, 6-134 months), and long-term survival (more than 5 years) was only documented in two cases without lymph node metastasis (including the present case).
  • In conclusion, the experience gained in the present and previous cases suggests that long-term survival is possible following a curative resection in selected patients with ampullary SRCC without nodal involvement.
  • Due to the lack of sufficient evidence, additional reports are warranted to determine whether SRCC also portends a poor prognosis in patients with ampullary cancer.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Signet Ring Cell / pathology. Common Bile Duct Neoplasms / pathology. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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  • (PMID = 18030577.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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83. Hatzaras I, George N, Muscarella P, Melvin WS, Ellison EC, Bloomston M: Predictors of survival in periampullary cancers following pancreaticoduodenectomy. Ann Surg Oncol; 2010 Apr;17(4):991-7
MedlinePlus Health Information. consumer health - Pancreatic Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cancers of the ampulla of Vater, distal common bile duct, and pancreas are known to have dismal prognosis.
  • It is often reported that ampullary cancers are less aggressive relative to the other periampullary carcinomas.
  • METHODS: We reviewed the records of all patients who underwent pancreaticoduodenectomy for periampullary carcinoma between 1992 and 2007 at the Ohio State University Medical Center.
  • RESULTS: 346 consecutive periampullary malignancies (249 pancreatic cancers, 79 ampullary carcinomas, 18 extrahepatic cholangiocarcinomas) treated by pancreaticoduodenectomy were identified.
  • Pancreatic cancer histology correlated with the shortest median survival (17.1 months), followed by cholangiocarcinoma (17.9 months) and ampullary carcinoma (44.3 months) (P < 0.001).
  • CONCLUSIONS: Although ampullary cancers have the best prognosis overall, when controlled for tumor stage, only presence of neural invasion and nodal metastasis predict poor survival following pancreaticoduodenectomy.

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  • (PMID = 20108122.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA133250-01; United States / NCI NIH HHS / CA / K12 CA133250; United States / NCI NIH HHS / CA / 1 K12 CA133250; United States / NCI NIH HHS / CA / K12 CA133250-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS190333; NLM/ PMC2861840
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84. Touzios JG, Krzywda B, Nakeeb A, Pitt HA: Exercise-induced cholangitis and pancreatitis. HPB (Oxford); 2005;7(2):124-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Twelve episodes of cholangitis occurred in six patients who had undergone hepaticojejunostomy for biliary stricture (N=3), Type I choledochal cyst (N=2), or pancreatoduodenectomy for renal cell carcinoma metastatic to the pancreas (N=1).
  • Four episodes of pancreatitis occurred in two patients who had undergone pancreatoduodenectomy for ampullary carcinoma or chronic pancreatitis.

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  • (PMID = 18333175.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2023936
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85. Gandini R, Fabiano S, Pipitone V, Spinelli A, Reale CA, Colangelo V, Pampana E, Romagnoli A, Simonetti G: Management of biliary neoplastic obstruction with two different metallic stents implanted in one session. Cardiovasc Intervent Radiol; 2005 Jan-Feb;28(1):48-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The efficacy of the "one-step" technique using two different metallic stents (Wallstent and Ultraflex) and associated rate of complications was studied in 87 patients with jaundice secondary to malignant biliary obstruction, with bilirubin level less than 15 mg/dl and Bismuth type 1 or 2 strictures.
  • The cause of the obstruction was pancreatic carcinoma in 38 patients (44%), lymph node metastasis in 20 patients (23%), gallbladder carcinoma in 13 patients (15%), cholangiocarcinoma in 12 patients (14%) and ampullary carcinoma in four patients (5%).

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  • (PMID = 15772722.001).
  • [ISSN] 0174-1551
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Berberat PO, Künzli BM, Gulbinas A, Ramanauskas T, Kleeff J, Müller MW, Wagner M, Friess H, Büchler MW: An audit of outcomes of a series of periampullary carcinomas. Eur J Surg Oncol; 2009 Feb;35(2):187-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Non-pancreatic periampullary carcinoma such as ampullary carcinoma (AmpCA), distal cholangiocellular carcinoma (CholCA) and duodenal carcinoma (DuoCA) have a better prognosis than pancreatic head adenocarcinoma (PanCA).
  • This study describes the outcome and parameters, which predict survival of non-pancreatic periampullary carcinoma after resection.
  • METHODS AND PATIENTS: Data from 148 consecutive patients with non-pancreatic periampullary carcinomas were recorded prospectively between 1993 and 2005 and analyzed using univariate and multivariate models.
  • RESULTS: One hundred thirty-three of 148 (90%) patients were resected for histologically proven non-pancreatic periampullary carcinomas.
  • CONCLUSION: Only T1/T2 ampullary carcinomas have a good prognosis, whereas T3/T4 ampullary tumors show aggressiveness similar to that of pancreatic head adenocarcinomas.
  • [MeSH-major] Ampulla of Vater. Biliary Tract Surgical Procedures / methods. Carcinoma / surgery. Clinical Audit / methods. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18343082.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
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87. Morise Z, Sugioka A, Tokoro T, Tanahashi Y, Okabe Y, Kagawa T, Takeura C: Surgery and chemotherapy for intrahepatic cholangiocarcinoma. World J Hepatol; 2010 Feb 27;2(2):58-64

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, locoregional extension of these tumors is usually advanced with intrahepatic and lymph-node metastases at the time of diagnosis.
  • Only a small number of ICC cases, accompanied with ECC, gall bladder carcinoma, and ampullary carcinoma, have been reported in the studies of chemotherapy due to the rarity of the disease.
  • However, in some reports, significant anti-cancer effects were achieved with a response rate of up to 40% and a median survival of one year.

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  • (PMID = 21160974.001).
  • [ISSN] 1948-5182
  • [Journal-full-title] World journal of hepatology
  • [ISO-abbreviation] World J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998957
  • [Keywords] NOTNLM ; Chemotherapy / Intrahepatic cholangiocarcinoma / Surgery
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88. Park JS, Yoon DS, Park YN, Lee WJ, Chi HS, Kim BR: Transduodenal local resection for low-risk group ampulla of vater carcinoma. J Laparoendosc Adv Surg Tech A; 2007 Dec;17(6):737-42
MedlinePlus Health Information. consumer health - Intestinal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transduodenal local resection for low-risk group ampulla of vater carcinoma.
  • BACKGROUND: Carcinoma of the ampulla of Vater has a more favorable prognosis, compared to other malignant tumors of the periampullary region, because it usually presents with symptoms in the early stage.
  • However, treatment by local resection only of the ampullary carcinoma remains controversial.
  • The aim of this study was to evaluate the treatment results of the ampulla of Vater carcinoma according to different types of operation in low-risk-group patients.
  • METHODS: We retrospectively reviewed the medical records of 17 low-risk-group patients among a total of 102 patients with ampulla of Vater carcinoma who had underwent curative surgery from 1992 to 2002.
  • CONCLUSIONS: Transduodenal local resection is a comparable mode of operation for low-risk-group patients with Ampulla of Vater carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Laparoscopy / methods

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  • (PMID = 18158802.001).
  • [ISSN] 1092-6429
  • [Journal-full-title] Journal of laparoendoscopic & advanced surgical techniques. Part A
  • [ISO-abbreviation] J Laparoendosc Adv Surg Tech A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Miyazaki M, Takada T, Miyakawa S, Tsukada K, Nagino M, Kondo S, Furuse J, Saito H, Tsuyuguchi T, Chijiiwa K, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Pancreatic Surgery, Japan Society of Clinical Oncology: Risk factors for biliary tract and ampullary carcinomas and prophylactic surgery for these factors. J Hepatobiliary Pancreat Surg; 2008;15(1):15-24

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors for biliary tract and ampullary carcinomas and prophylactic surgery for these factors.
  • Curative resection is the only treatment for biliary tract cancer that achieves long-term survival.
  • However, patients with advanced biliary tract cancer have only a limited prognosis even after radical surgical resection.
  • Thus, to improve the longterm results, the early detection of biliary tract cancer and subsequent cure seem to be essential.
  • It has been reported that pancreaticobiliary maljunction (PBM) with bile duct dilatation is a risk factor for gallbladder cancer and bile duct cancer, while PBM without bile duct dilatation is a risk factor for gallbladder cancer.
  • Adenoma and dysplasia have been regarded as precancerous lesions of gallbladder cancer.
  • Although gallstones seem to be closely associated with gallbladder cancer, there is no evidence of a direct causal relationship between gallstones and gallbladder cancer.
  • Controversy remains as to whether adenomyomatosis of the gallbladder and porcelain gallbladder are associated with gallbladder cancer.
  • With respect to ampullary carcinoma, adenoma of the ampulla is considered to be a precancerous lesion.
  • [MeSH-major] Ampulla of Vater. Biliary Tract Neoplasms / prevention & control. Carcinoma / prevention & control

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  • (PMID = 18274840.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Japan
  • [Number-of-references] 39
  • [Other-IDs] NLM/ PMC2794357
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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90. Tsukada K, Takada T, Miyazaki M, Miyakawa S, Nagino M, Kondo S, Furuse J, Saito H, Tsuyuguchi T, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Diagnosis of biliary tract and ampullary carcinomas. J Hepatobiliary Pancreat Surg; 2008;15(1):31-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of biliary tract and ampullary carcinomas.
  • Diagnostic methods for biliary tract carcinoma and the efficacy of these methods are discussed.
  • Neither definite methods for early diagnosis nor specific markers are available in this disease.
  • Diagnoses of extrahepatic bile duct cancer and ampullary carcinoma are often made based on the presence of obstructive jaundice.
  • Although rare, abdominal pain and pyrexia, as well as abnormal findings of the hepatobiliary system detected by hemato-biochemical examination, serve as a clue to making a diagnosis of these diseases.
  • On the other hand, the early diagnosis of gallbladder cancer is scarcely possible on the basis of clinical symptoms, so when this cancer is found with the onset of abdominal pain and jaundice, it is already advanced at the time of detection, thus making a cure difficult.
  • When gallbladder cancer is suspected, enhanced CT is carried out.
  • However, direct biliary tract imaging is necessary for making a precise diagnosis of the horizontal extension of bile duct cancer.
  • [MeSH-major] Ampulla of Vater. Biliary Tract Neoplasms / diagnosis. Carcinoma / diagnosis

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  • (PMID = 18274842.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794353
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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91. Nassar H, Albores-Saavedra J, Klimstra DS: High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol; 2005 May;29(5):588-94
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  • [Title] High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.
  • We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of lung tumors into small cell carcinoma (SCC, 6 cases) and large cell neuroendocrine carcinoma (LCNEC, 8 cases) types.
  • The immunohistochemical findings were compared with those of 13 cases of primary poorly differentiated ampullary adenocarcinomas (PDACA) lacking neuroendocrine morphology.
  • Overall, 64% of patients with ampullary HGNEC died of disease (mean follow-up, 14.5 months).
  • Two HGNECs were combined with a conventional adenocarcinoma and another with a squamous cell carcinoma component.
  • In conclusion, HGNECs of the ampulla are rare (2%-3% of ampullary tumors in our material).
  • The clinical course parallels that of their pulmonary counterparts and appears to be worse than that of locally advanced ampullary adenocarcinomas.
  • Loss of Rb expression, a characteristic finding in pulmonary SCCs, is present in almost half of ampullary HGNECs.
  • Thus, there are differences in the molecular phenotypes of these two types of ampullary carcinoma, supporting the distinction of poorly differentiated carcinomas with a neuroendocrine phenotype from those without.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Survival Rate

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  • (PMID = 15832081.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Singh S, Sachdev AK, Chaudhary A, Agarwal AK: Palliative surgical bypass for unresectable periampullary carcinoma. Hepatobiliary Pancreat Dis Int; 2008 Jun;7(3):308-12
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  • [Title] Palliative surgical bypass for unresectable periampullary carcinoma.
  • BACKGROUND: Around 60% to 80% of patients with periampullary carcinoma are unresectable either due to distant metastasis or local vascular invasion.
  • This study was conducted to assess the results of palliative surgical bypass for patients with unresectable periampullary carcinoma at our hospital, a tertiary referral center of Northern India.
  • METHOD: The study group comprised 204 patients who had undergone surgical bypass for advanced periampullary carcinoma over the last 15 years.
  • RESULTS: Between January 1990 and December 2004, 204 patients (128 males, 76 females) consisting of 179 patients with carcinoma of head of the pancreas, 14 patients with ampullary carcinoma, 8 patients with lower end cholangiocarcinoma and 3 patients with duodenal carcinoma underwent surgical bypass.
  • [MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Gastrostomy / methods. Jejunostomy / methods. Palliative Care / methods
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Treatment Outcome

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  • (PMID = 18522888.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
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93. Aranha GV, Aaron JM, Shoup M: Critical analysis of a large series of pancreaticogastrostomy after pancreaticoduodenectomy. Arch Surg; 2006 Jun;141(6):574-9; discussion 579-80
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  • The 4 most common indications for surgery were pancreatic adenocarcinoma (41.3%), ampullary carcinoma (17.0%), duodenal carcinoma (7.2%), and chronic pancreatitis (7.2%).
  • The most common complications were pancreatic fistulae (13.6%), 1 of which was thought to cause 1 of 2 mortalities in this series.
  • Pancreatic fistulae developing after pancreaticogastrostomy were significantly related to a low preoperative alkaline phosphatase level and surgery for nonpancreatic pathologic findings.
  • CONCLUSIONS: Pancreaticogastrostomy is a safe operation associated with low mortality and morbidity rates and a pancreatic fistula rate of 13.6%.
  • It should be considered as a suitable alternative for management of the pancreatic remnant after pancreaticoduodenectomy.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Duodenal Neoplasms / surgery. Female. Humans. Length of Stay. Male. Middle Aged. Pancreatic Fistula / etiology. Pancreatic Neoplasms / surgery. Pancreatitis, Chronic / surgery. Retrospective Studies. Risk Factors

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  • (PMID = 16785358.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Liu JF, Li A, Liu Q, Zhou JS, Sun JB, Li D: [Surgical treatment of 475 patients with periampullary carcinoma]. Zhonghua Zhong Liu Za Zhi; 2005 Apr;27(4):251-3
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  • [Title] [Surgical treatment of 475 patients with periampullary carcinoma].
  • OBJECTIVE: To compare of the outcome of all patients who received surgical treatment in one institute for periampullary carcinoma during different intervals over the past 40 years.
  • METHODS: Retrospective review of 475 patients suffering from periampullary carcinoma in intervals 1958 approximately 1976, 1977 approximately 1987, 1988 approximately 1998 and 1999 approximately 2003 is presented.
  • RESULTS: In interval 1958 approximately 1976, for 128 patients, the tumor resection rate was: pancreatic carcinoma (PC) 26.6% (21/79), ampullary carcinoma (AC) 86.2% (25/29), distal bile duct cancer (DBDC) 38.5% (5/13), and duodenal cancer (DC) 57.1% (4/7).
  • From 1999 to 2003, none of the 130 periampullary carcinoma patients had received biliary drainage before operation.
  • CONCLUSION: Mortality and complication have become significantly lower because of effective improvement in the perioperative preparation and the care after surgery of periampullary cancer in the recent years.
  • Even though the accurate diagnosis has become increasing earlier than before, the resection rate and prognosis of periampullary carcinoma remain poor.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 15949432.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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95. Das P, Wolff RA, Abbruzzese JL, Varadhachary GR, Evans DB, Vauthey JN, Baschnagel A, Delclos ME, Krishnan S, Janjan NA, Crane CH: Concurrent capecitabine and upper abdominal radiation therapy is well tolerated. Radiat Oncol; 2006;1:41
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  • These patients included 28 (32%) with pancreatic adenocarcinoma, 18 (20%) with cholangiocarcinoma, 11 (13%) with ampullary carcinoma, 11 (13%) with other primary tumors, 14 (16%) with liver metastases, and 6 (7%) with metastases at other sites.
  • [MeSH-minor] Antimetabolites, Antineoplastic / administration & dosage. Capecitabine. Dose-Response Relationship, Radiation. Drug Administration Schedule. Gastrointestinal Neoplasms / drug therapy. Gastrointestinal Neoplasms / radiotherapy. Humans. Neoplasm Metastasis. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 17062148.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC1634749
  • [General-notes] NLM/ Original DateCompleted: 20070808
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96. De Jong MC, Farnell MB, Sclabas G, Cunningham SC, Cameron JL, Geschwind JF, Wolfgang CL, Herman JM, Edil BH, Choti MA, Schulick RD, Nagorney DM, Pawlik TM: Liver-directed therapy for hepatic metastases in patients undergoing pancreaticoduodenectomy: a dual-center analysis. Ann Surg; 2010 Jul;252(1):142-8
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  • RESULTS: Primary tumor histology included neuroendocrine carcinoma (34.9%), pancreatic ductal adenocarcinoma (33.4%), distal cholangiocarcinoma (8.7%), ampullary carcinoma (7.1%), duodenal carcinoma (4.0%), or other (11.9%).
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Carcinoma / pathology. Carcinoma, Ductal / pathology. Carcinoma, Neuroendocrine / pathology. Cholangiocarcinoma / pathology. Duodenal Neoplasms / pathology. Duodenal Neoplasms / secondary. Female. Humans. Male. Middle Aged. Pancreatic Neoplasms / pathology

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  • (PMID = 20531007.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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97. Zhang JW, Zhao H, Bai XF, Fang Y, Wang CF, Zhao P: [Analysis of risk factors of stress-related ulcer and gastrointestinal hemorrhage after pancreaticoduodenectomy]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):40-3
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  • METHODS: From May 1999 to July 2007, 285 periampullary cancer patients underwent pancreaticoduodenectomy in our hospital.
  • Pathological examination showed pancreatic cancer in 5 cases, duodenal cancer in 8, common bile duct cancer in 10, ampullary carcinoma in 11, and solid-pseudopapillary tumors in 1.
  • [MeSH-major] Common Bile Duct Neoplasms / complications. Gastrointestinal Hemorrhage / etiology. Pancreatic Neoplasms / complications. Pancreaticoduodenectomy / adverse effects. Peptic Ulcer / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Alcoholism / complications. Ampulla of Vater. Bilirubin / blood. Duodenal Neoplasms / complications. Duodenal Neoplasms / pathology. Duodenal Neoplasms / surgery. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Prealbumin / metabolism. Retrospective Studies. Risk Factors. Stress, Psychological / complications. Young Adult

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  • (PMID = 20211066.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Prealbumin; RFM9X3LJ49 / Bilirubin
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98. Gaujoux S, Cortes A, Couvelard A, Noullet S, Clavel L, Rebours V, Lévy P, Sauvanet A, Ruszniewski P, Belghiti J: Fatty pancreas and increased body mass index are risk factors of pancreatic fistula after pancreaticoduodenectomy. Surgery; 2010 Jul;148(1):15-23
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  • [Title] Fatty pancreas and increased body mass index are risk factors of pancreatic fistula after pancreaticoduodenectomy.
  • BACKGROUND: Pancreatic fistula (PF) after pancreatoduodenectomy (PD) remains a challenging problem.
  • The only commonly accepted risk factor is the soft consistency of the pancreatic remnant.
  • All data, including commonly accepted risk factors for PF and PF defined according to the International Study Group of Pancreatic Fistula, were collected prospectively.
  • On the pancreatic margin, a score of fibrosis and a score of fatty infiltration were assessed by a pathologist blinded to the postoperative course.
  • In univariate analysis, male sex, age greater than 58 years, body mass index (BMI) > or =25 kg/m(2), pre-operative high blood pressure, operation for nonintraductal papillary and mucinous neoplasm (IPMN) disease and for ampullary carcinoma, operative time, blood loss, soft consistency of the pancreatic remnant, absence of pancreatic fibrosis, and presence of fatty infiltration of the pancreas were associated with a greater risk of PF.
  • In a multivariate analysis, only BMI > or =25 kg/m(2), absence of pancreatic fibrosis, and presence of fatty pancreas were significant predictors of PF.
  • CONCLUSION: The presence of an increased BMI, the presence of fatty pancreas, and the absence of pancreatic fibrosis as risk factors of PF allows a more precise and objective prediction of PF than the consistency of pancreatic remnant alone.
  • [MeSH-major] Body Mass Index. Pancreas / pathology. Pancreatic Fistula / etiology. Pancreaticoduodenectomy / adverse effects. Postoperative Complications / etiology

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  • [Copyright] Copyright 2010. Published by Mosby, Inc.
  • (PMID = 20138325.001).
  • [ISSN] 1532-7361
  • [Journal-full-title] Surgery
  • [ISO-abbreviation] Surgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Ayaru L, Kurzawinski TR, Shankar A, Webster GJ, Hatfield AR, Pereira SP: Complications and diagnostic difficulties arising from biliary self-expanding metal stent insertion before definitive histological diagnosis. J Gastroenterol Hepatol; 2008 Feb;23(2):315-20
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  • [Title] Complications and diagnostic difficulties arising from biliary self-expanding metal stent insertion before definitive histological diagnosis.
  • BACKGROUND: Self-expanding metal bile duct stents provide good palliation for inoperable malignant disease.
  • However, problems may arise if metal stents are inserted before definitive histological diagnosis.
  • METHODS: A retrospective case note review was conducted of patients referred to a tertiary pancreaticobiliary center between 1992 and 2004 in whom a metal bile duct stent was inserted for presumed unresectable malignant disease before definitive histological diagnosis.
  • Final diagnoses were: group 1, benign disease (n = 3); group 2, resectable malignancy (n = 2); group 3, unresectable malignancy (n = 12); and group 4, diagnosis remains uncertain (n = 4).
  • In group 2, both patients underwent pancreaticoduodenectomy for ampullary carcinoma, 2 and 6 months after presentation.
  • In group 3, the median time to a confirmed malignant diagnosis was 2 months (range 1-27 months).
  • Overall in eight patients, the metal stents caused artifacts on computed tomography and/or were associated with tissue in-growth making the differentiation between benign and malignant disease difficult.
  • CONCLUSION: These cases indicate that metal bile duct stent insertion before definitive histological diagnosis can be problematic.
  • [MeSH-major] Bile Ducts. Biliary Tract Neoplasms / pathology. Biliary Tract Neoplasms / therapy. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / therapy. Stents / adverse effects
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biliary Tract Diseases / pathology. Equipment Design. Female. Humans. Male. Metals. Middle Aged. Palliative Care. Pancreatic Diseases / pathology. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Pancreatic Cancer.
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  • (PMID = 18289360.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0801588
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Metals
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100. Peng SY, Hong DF, Liu YB, Li JT, Tao F, Tan ZJ: [A pancreas suture-less type II binding pancreaticogastrostomy]. Zhonghua Wai Ke Za Zhi; 2009 Dec 1;47(23):1764-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: From November 2008 to May 2009, 26 patients underwent pancreaticoduodenectomy and mid-segmentectomy of pancreas with type II BPG reconstruction, including 13 cases of pancreatic head cancer, 3 cases of duodenal adenocarcinoma, 2 cases of ampullary carcinoma, 4 cases of cholangiocarcinoma, 1 case of bile duct cell severe atypical hyperplasia, and 1 case of stomach cancer.
  • No mortality or pancreatic leakage occurred.

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  • (PMID = 20193541.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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