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6. Murakami Y, Uemura K, Sasaki M, Morifuji M, Hayashidani Y, Sudo T, Sueda T: Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis. J Gastrointest Surg; 2005 Mar;9(3):389-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis.
  • We herein report a rare occurrence of duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis (FAP).
  • During the current admission, the patient was diagnosed with adenocarcinoma in the Vater's ampulla using imaging and pathological examinations.
  • [MeSH-minor] Adult. Ampulla of Vater / pathology. Cholangiopancreatography, Endoscopic Retrograde / methods. Duodenoscopy / methods. Female. Follow-Up Studies. Humans. Neoplasm, Residual / pathology. Neoplasm, Residual / surgery. Pylorus. Risk Assessment. Treatment Outcome

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  • (PMID = 15749602.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Kayahara M, Ohta T: Gross appearance of the ampullary tumor predicts lymph node metastasis and outcome. Dig Surg; 2010;27(2):127-31
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  • [Title] Gross appearance of the ampullary tumor predicts lymph node metastasis and outcome.
  • BACKGROUND/AIMS: Patterns of lymph node involvement in carcinoma of the papilla of Vater (CPV) have not been studied in detail to date, and factors associated with lymphatic metastases and surgical outcome of this disease remain to be determined.
  • [MeSH-major] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Proportional Hazards Models. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2010 S. Karger AG, Basel.
  • (PMID = 20551657.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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8. Morise Z, Sugioka A, Tokoro T, Tanahashi Y, Okabe Y, Kagawa T, Takeura C: Surgery and chemotherapy for intrahepatic cholangiocarcinoma. World J Hepatol; 2010 Feb 27;2(2):58-64
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  • However, locoregional extension of these tumors is usually advanced with intrahepatic and lymph-node metastases at the time of diagnosis.
  • Only a small number of ICC cases, accompanied with ECC, gall bladder carcinoma, and ampullary carcinoma, have been reported in the studies of chemotherapy due to the rarity of the disease.
  • However, in some reports, significant anti-cancer effects were achieved with a response rate of up to 40% and a median survival of one year.

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  • (PMID = 21160974.001).
  • [ISSN] 1948-5182
  • [Journal-full-title] World journal of hepatology
  • [ISO-abbreviation] World J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2998957
  • [Keywords] NOTNLM ; Chemotherapy / Intrahepatic cholangiocarcinoma / Surgery
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9. Chong VH, Telisinghe PU, Yapp SK, Jalihal A: Biliary strictures secondary to tuberculosis and early ampullary carcinoma. Singapore Med J; 2009 Mar;50(3):e94-6
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  • [Title] Biliary strictures secondary to tuberculosis and early ampullary carcinoma.
  • Malignancies are important causes and are often unresectable at the time of diagnosis.
  • We report a 67-year-old man with unexpected findings of obstructive jaundice secondary to biliary TB and an early ampullary tumour.
  • [MeSH-minor] Aged. Ampulla of Vater / pathology. Biliary Tract Surgical Procedures. Constriction, Pathologic / pathology. Humans. Male. Risk Factors

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  • (PMID = 19352560.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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10. Yildirim N, Oksüzoğlu B, Budakoğlu B, Vural M, Abali H, Uncu D, Zengin N: Primary duodenal diffuse large cell non-hodgkin lymphoma with involvement of ampulla of Vater: report of 3 cases. Hematology; 2005 Oct;10(5):371-4
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  • [Title] Primary duodenal diffuse large cell non-hodgkin lymphoma with involvement of ampulla of Vater: report of 3 cases.
  • Periampullary lymphoma or lymphomatous involvement of ampulla of Vater is even rarer.
  • Since, periampullary lymphoma is not easy to differentiate from epithelial carcinoma of these sites clinically and radiologically, accurate histopathological diagnosis is essential to plan optimal treatment strategy.
  • In this report, we present three cases of duodenal diffuse large cell lymphoma with involvement of ampulla of Vater, two of whom presented with the initial signs of obstructive jaundice.
  • One of the icteric patients was only diagnosed histopathologically following an explorative laparotomy with the initial diagnosis of carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology. Lymphoma, Large B-Cell, Diffuse / pathology


11. Ishii Y, Takahashi M, Yoshida S, Suzuki K: [A case of hepatic metastases of ampullary carcinoma which completely responded to intrahepatic infusion of 5-FU with low-dose l-leucovorin]. Gan To Kagaku Ryoho; 2005 Aug;32(8):1175-7
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  • [Title] [A case of hepatic metastases of ampullary carcinoma which completely responded to intrahepatic infusion of 5-FU with low-dose l-leucovorin].
  • A 70-year-old man was admitted with an ampullary carcinoma with multiple hepatic metastases.
  • [MeSH-major] Ampulla of Vater. Duodenal Neoplasms / pathology. Fluorouracil / administration & dosage. Leucovorin / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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  • (PMID = 16121924.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
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12. O'Connell JB, Maggard MA, Manunga J Jr, Tomlinson JS, Reber HA, Ko CY, Hines OJ: Survival after resection of ampullary carcinoma: a national population-based study. Ann Surg Oncol; 2008 Jul;15(7):1820-7
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  • [Title] Survival after resection of ampullary carcinoma: a national population-based study.
  • BACKGROUND: Ampullary cancer is the second most common periampullary cancer, with a resection and survival rate more favorable than that for pancreatic cancer.
  • Our objective was to complete a population-based analysis of patients undergoing resection for ampullary carcinoma and compare it with outcomes in the published literature.
  • METHODS: Patients diagnosed with ampullary cancer reported in the Surveillance, Epidemiology, and End Results program (1988-2003) were collected.
  • RESULTS: Of the 3292 ampullary cancer patients, 1301 (40%) underwent resection.
  • The cancer registry data showed less early stage disease, higher perioperative mortality, and lower 5-year survival compared with published reports.
  • CONCLUSIONS: This is the largest population-based analysis of ampullary carcinoma.
  • Resection rates and survival at the national level are lower, in general, compared with cancer center reports, which may have implications for regionalizing these procedures.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Survival Analysis. Survival Rate. Treatment Outcome

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  • [CommentIn] Ann Surg Oncol. 2008 Jul;15(7):1813-4 [18425553.001]
  • (PMID = 18369675.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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13. Woo SM, Ryu JK, Lee SH, Yoo JW, Park JK, Kim YT, Jang JY, Kim SW, Kang GH, Yoon YB: Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma. Ann Surg Oncol; 2007 Nov;14(11):3195-201
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  • [Title] Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma.
  • BACKGROUND: Ampullary carcinoma is often considered to have a better prognosis than distal extrahepatic cholangiocarcinoma.
  • METHODS: Clinicopathologic factors and the long-term outcomes of 163 patients with ampullary carcinoma after radical resection were retrospectively evaluated and compared with those of 91 patients with distal extrahepatic cholangiocarcinoma.
  • RESULTS: Among the 163 ampullary carcinomas, T1 stage, well-differentiated tumors and perineural invasion were 45 (28%), 73 (45%), and 23 (14%), respectively, whereas, only five (6%) were T1 stage, 15 (17%) were well differentiated, and 63 (69%) showed perineural invasion (p < 0.001, for all) in distal extrahepatic cholangiocarcinomas.
  • More patients with distal extrahepatic cholangiocarcinoma had liver metastasis than ampullary carcinoma (24% vs. 10%, p = 0.004).
  • Multivariate analysis identified venous invasion and perineural invasion as risk factors for recurrence of ampullary carcinoma after radical resection.
  • Overall five-year survival of patients with ampullary cancer was higher than that of patients with distal extrahepatic cholangiocarcinoma (68% vs. 54%; p = 0.033).
  • CONCLUSION: Earlier diagnosis and the less frequent occurrence of pathological factors associated with tumor invasiveness in ampullary carcinoma than in distal extrahepatic cholangiocarcinoma may explain its association with a better prognosis.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Extrahepatic / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17710498.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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4. Hopf S, Buchalla R, Scheil F, Heusermann U, Börm W: Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review. J Neurooncol; 2009 Oct;95(1):141-145
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review.
  • Carcinoma of the ampulla of Vater is an uncommon tumor accounting for approximately 0.2% of all gastrointestinal malignancies, with an estimated incidence of less than 6 cases per 1,000,000 population per year.
  • We report about an extremely rare case of a 54-year-old female patient with a right frontal skull metastases of an ampulla of Vater adenocarcinoma 5 years after pylorus-preserving pancreaticoduodenectomy.
  • Literature review revealed only one published case of cranial bone metastases of carcinoma of the ampulla of Vater.
  • To the best of our knowledge this is the first case report of skull metastases of ampullary adenocarcinoma after a symptom-free interval of 5 years after R0 resection of the primary tumor, and the second published case that involves the skull.
  • [MeSH-major] Adenocarcinoma / etiology. Adenocarcinoma / pathology. Ampulla of Vater / pathology. Skull Neoplasms / secondary. Whipple Disease / surgery

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  • (PMID = 19444594.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 15
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15. Nagino M, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Kondo S, Furuse J, Saito H, Tsuyuguchi T, Yoshikawa T, Ohta T, Kimura F, Ohta T, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Preoperative biliary drainage for biliary tract and ampullary carcinomas. J Hepatobiliary Pancreat Surg; 2008;15(1):25-30
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  • [Title] Preoperative biliary drainage for biliary tract and ampullary carcinomas.
  • However, the morbidity and mortality of extended hepatectomy for biliary cancer is still high, and the most common cause of death is hepatic failure; therefore, preoperative biliary drainage is desirable in patients who are to undergo extended hepatectomy. CQ 2.
  • Which is better, unilateral or bilateral biliary drainage, in malignant hilar obstruction?
  • [MeSH-major] Ampulla of Vater. Biliary Tract Neoplasms / therapy. Carcinoma / therapy. Drainage / methods

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  • (PMID = 18274841.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794354
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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16. Riediger H, Makowiec F, Fischer E, Adam U, Hopt UT: Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection. J Gastrointest Surg; 2006 Sep-Oct;10(8):1106-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Between July 1994 and December 2004, 222 PD (78% pylorus preserving, 19% Whipple, and 3% total pancreatectomy) were performed for malignant disease.
  • Long-term survival was analyzed in 165 patients with pancreatic (n = 110), ampullary (n = 33), or distal bile (n = 22) duct cancer using univariate (log-rank) and multivariate (Cox regression) methods.
  • Five-year survival rates were 15% in cancer of the pancreatic head, 22% in ampullary cancer, and 24% in distal bile duct cancer (P = 0.02).
  • Univariate survival analysis of the 110 patients with cancer of the pancreatic head revealed that a histologically undifferentiated tumor (P = 0.05) and positive resection margins (P = 0.02) were associated with a poorer survival.
  • In case of tumor adherence or infiltration, combined resection of the pancreatic head and the vein should always be considered in the absence of other contraindications for resection.
  • [MeSH-major] Mesenteric Veins / pathology. Mesenteric Veins / surgery. Pancreatic Neoplasms. Pancreaticoduodenectomy / methods. Portal Vein / pathology. Portal Vein / surgery. Vascular Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Morbidity / trends. Neoplasm Invasiveness. Postoperative Period. Prospective Studies. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 16966029.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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17. Perrone G, Santini D, Verzì A, Vincenzi B, Borzomati D, Vecchio F, Coppola R, Antinori A, Magistrelli P, Tonini G, Rabitti C: COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables. J Clin Pathol; 2006 May;59(5):492-6
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  • [Title] COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables.
  • To data, there have been few clinicopathological studies on COX-2 expression in human ampullary carcinoma and no data have been reported about its relation with tumour angiogenesis.
  • OBJECTIVE: To investigate by immunohistochemistry the expression of COX-2 and the angiogenesis process in a series of primary untreated ampullary carcinomas.
  • METHODS: Tissue samples from 40 archival ampullary carcinomas were analysed for COX-2, vascular endothelial growth factor (VEGF), and an endothelial cell marker von Willebrand factor (vWF) by immunohistochemistry, using specific antibodies.
  • CONCLUSIONS: COX-2 is highly expressed in ampullary carcinomas.
  • This suggests an involvement of the COX-2 pathway in ampullary tumour associated angiogenesis, providing a rationale for targeting COX-2 in the treatment of ampullary cancer.
  • [MeSH-major] Ampulla of Vater. Carcinoma / enzymology. Common Bile Duct Neoplasms / enzymology. Cyclooxygenase 2 / analysis. Neovascularization, Pathologic / etiology

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  • (PMID = 16489179.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Vascular Endothelial Growth Factor A; 0 / von Willebrand Factor; EC 1.14.99.1 / Cyclooxygenase 2
  • [Other-IDs] NLM/ PMC1860297
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18. Sakorafas GH, Giannopoulos GA, Parasi A, Konstantoudakis G, Tzanakis N, Stergiopoulos S, Peros G: Large somatostatin-producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease. Case report and review of the literature. JOP; 2008;9(5):633-9
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  • [Title] Large somatostatin-producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease. Case report and review of the literature.
  • CASE REPORT: We present the case of a 49-year-old female patient with von Recklinghausen's disease and an incidentally diagnosed ampullary neoplasm.
  • Histology and immunohistochemistry showed that the duodenal tumor was an ampullary somatostatin-producing endocrine carcinoma while the gastric tumor was a gastrointestinal stromal tumor (GIST).
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Neurofibromatosis 1 / complications. Somatostatinoma / complications

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  • (PMID = 18762695.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
  • [Number-of-references] 28
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19. Kalogeraki A, Tzardi M, Papadakis M, Stathopoulos E, Kouroumalis E, Zoras O: Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma. Acta Cytol; 2010 Jan-Feb;54(1):39-42
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  • [Title] Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma.
  • OBJECTIVE: To evaluate apoptosis and cell proliferation on cytologic specimens (smears) from endoscopic retrograde cholangiopancreatography in patients with ampulary carcinoma and to correlate that relationship with the grade of the tumors.
  • STUDY DESIGN: Forty patients (23 males and 17 females) aged 45-81 who underwent endoscopic retrograde cholangiopancreatography were diagnosed by cytology as having ampullary adenocarcinoma and the diagnoses were confirmed histologically after an operation.
  • RESULTS: The TUNEL indices were 0.4 +/- 0.07, 0.91 +/- 0.33 and 3.1 +/- 0.9 in well, moderate and poorly differentiated ampullary carcinoma, respectively.
  • The differences in both TUNEL and MIB-1 labeling indices were statistically significant between well, moderately and poorly differentiated ampullary carcinoma, and a positive correlation was found between TUNEL and the MIB-1 indices.
  • CONCLUSION: Apoptosis (cell death) and cell proliferation increase as the grade of the differentiation decreases in ampullary carcinoma, suggesting a rapid turnover of the tumor cells with lower grates of differentiation, and apoptosis may play an important role in the growth of the tumors in patients with ampullary carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Apoptosis. Cell Proliferation. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Antinuclear / analysis. Antibodies, Monoclonal / analysis. DNA Fragmentation. Female. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 20306986.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody
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20. Peng SY, Hong DF, Liu YB, Tan ZJ, Li JT, Tao F: [Binding pancreaticogastrostomy]. Zhonghua Wai Ke Za Zhi; 2009 Jan 15;47(2):139-42
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  • METHODS: From May 2008 to October 2008, 15 patients were performed with BPG, included pancreatic head cancer in 7 cases, duodenal adenocarcinoma in 2 cases,mass-type chronic pancreatitis with pancreatolithiasis in 1 case, ampullary carcinoma in 1 case, gallbladder cancer in 1 case, islet cell tumor in 1 case and cholangiocarcinoma in 2 cases.

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  • (PMID = 19563012.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Will U, Bosseckert H, Meyer F: Correlation of endoscopic ultrasonography (EUS) for differential diagnostics between inflammatory and neoplastic lesions of the papilla of Vater and the peripapillary region with results of histologic investigation. Ultraschall Med; 2008 Jun;29(3):275-80
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  • [Title] Correlation of endoscopic ultrasonography (EUS) for differential diagnostics between inflammatory and neoplastic lesions of the papilla of Vater and the peripapillary region with results of histologic investigation.
  • PURPOSE: There is currently no imaging procedure that allows precise differentiation between inflammatory and malignant lesions of the papilla of Vater (papilla) in a satisfying manner.
  • The aim was to study whether endoscopic ultrasonography (EUS) as an initial diagnostic step 1. may have the potential to distinguish between different tissue characteristics, such as tumor growth or inflammation of the papilla, because of its high resolution capacity and 2. is superior to the accuracy of histologic investigations of mucosal biopsies by means of a prospective collection and retrospective evaluation of the data.
  • PATIENTS AND METHODS: Between 1995 and 2002, a significant pathologic finding in the papilla and the peripapillary region was revealed using EUS in 311 patients (overall, 4,832 EUS investigations); the comparison of this suspicion with the results of histologic investigation was only possible in 183 subjects.
  • Diagnosis was set up using EUS, which tried to differentiate between benign or malignant lesions of the papilla.
  • Histologic investigation of the 133 tumor lesions of the papilla became possible by taking deep transpapillary biopsies following papillotomy, papillectomy or by obtaining specimens from surgical resections.
  • RESULTS: Using EUS, differentiation between inflammatory and neoplastic lesions of the papilla or the peripapillary region was correct in 109 of 133 cases (82%), while suspected EUS-based diagnosis "papillitis stenosans" (inflammatory lesions of the papilla of Vater) in 4 subjects (3%) was corrected to adenoma and carcinoma, respectively (n=2 each) by histologic investigation.
  • In 20 of 133 patients with suspected neoplastic lesions, inflammatory lesion of the papilla of Vater was detected resulting in an overall sensitivity of 92.3% and specificity of 75.3%.
  • In patients with biliary symptoms, EUS can reliably visualize and characterize a malignant lesion as a first diagnostic tool (detection rate, 82%) and may be considered the basis for subsequent diagnostic steps for verifying diagnosis correctly, e. g., using histologic investigation.
  • [MeSH-major] Ampulla of Vater / pathology. Ampulla of Vater / ultrasonography. Common Bile Duct Diseases / ultrasonography. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / ultrasonography. Endosonography. Inflammation / pathology. Inflammation / ultrasonography
  • [MeSH-minor] Diagnosis, Differential. Humans. Retrospective Studies. Sphincter of Oddi / pathology. Sphincter of Oddi / ultrasonography

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  • (PMID = 18491258.001).
  • [ISSN] 0172-4614
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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22. Moguel MA, Brun FM, Pérez A, Pérez P, Torres LM: [Infectious complications after epidural analgesia to control pain after abdominal surgery]. Rev Esp Anestesiol Reanim; 2005 Jan;52(1):44-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Ampulla of Vater / surgery. Carcinoma, Ductal / surgery. Common Bile Duct Neoplasms / surgery. Diabetes Mellitus, Type 2 / complications. Equipment Contamination. Humans. Hydrocephalus / complications. Male. Middle Aged. Pain, Postoperative / drug therapy. Pancreatic Fistula / complications. Thoracic Vertebrae

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  • (PMID = 15747704.001).
  • [ISSN] 0034-9356
  • [Journal-full-title] Revista española de anestesiología y reanimación
  • [ISO-abbreviation] Rev Esp Anestesiol Reanim
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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23. Das P, Wolff RA, Abbruzzese JL, Varadhachary GR, Evans DB, Vauthey JN, Baschnagel A, Delclos ME, Krishnan S, Janjan NA, Crane CH: Concurrent capecitabine and upper abdominal radiation therapy is well tolerated. Radiat Oncol; 2006;1:41
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  • These patients included 28 (32%) with pancreatic adenocarcinoma, 18 (20%) with cholangiocarcinoma, 11 (13%) with ampullary carcinoma, 11 (13%) with other primary tumors, 14 (16%) with liver metastases, and 6 (7%) with metastases at other sites.
  • [MeSH-minor] Antimetabolites, Antineoplastic / administration & dosage. Capecitabine. Dose-Response Relationship, Radiation. Drug Administration Schedule. Gastrointestinal Neoplasms / drug therapy. Gastrointestinal Neoplasms / radiotherapy. Humans. Neoplasm Metastasis. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 17062148.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
  • [Other-IDs] NLM/ PMC1634749
  • [General-notes] NLM/ Original DateCompleted: 20070808
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24. Watanabe M, Midorikawa Y, Yamano T, Mushiake H, Fukuda N, Kirita T, Mizuguchi K, Sugiyama Y: Carcinoma of the papilla of Vater following treatment of pancreaticobiliary maljunction. World J Gastroenterol; 2009 Dec 28;15(48):6126-8
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  • [Title] Carcinoma of the papilla of Vater following treatment of pancreaticobiliary maljunction.
  • Pancreaticobiliary maljunction (PBM) is frequently associated with biliary cancer due to reflux of pancreatic enzymes into the choledochus, and even after surgery to correct the PBM such patients still have a risk of residual bile duct cancer.
  • Here, we report the case of a 59-year-old female with carcinoma of the papilla of Vater which developed 2.5 years after choledochoduodenostomy for PBM.
  • As a result, carcinoma of the papilla of Vater was diagnosed at an early stage, followed by surgical cure.
  • For early detection of periampullary cancer in patients undergoing surgery for PBM, careful long-term follow-up is needed.
  • [MeSH-major] Adenocarcinoma / etiology. Ampulla of Vater / pathology. Bile Ducts, Extrahepatic / abnormalities. Common Bile Duct Neoplasms / etiology. Pancreatic Ducts / abnormalities. Postoperative Complications / etiology

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  • (PMID = 20027689.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2797673
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25. Wu LH, Zhang W: [Prevention and treatment of complications after duodenopancreatectomy]. Di Yi Jun Yi Da Xue Xue Bao; 2005 Apr;25(4):461-3
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  • METHODS: The clinical data of 36 cases receiving duodenopancreatectomy during the last decade were analyzed, including 13 cases of ampullary carcinoma, 8 cases of carcinoma of the pancreas head, 8 cases of distal cholangiocarcinoma, and 7 cases of carcinoma of the duodenal papilla.
  • RESULTS: Complications occurred in 6 cases after duodenopancreatectomy including pancreatic fistula in 3 cases, bile duct fistula in 1 case, abdominal cavity hemorrhage in 1 case, and alimentary tract hemorrhage in 1 case, with an incidence rate of postoperative complications of 16.7%; and death occurred in 2 cases.
  • CONCLUSION: Adequate measures should be taken to reduce such complications as pancreatic fistula, bile duct fistula, abdominal cavity hemorrhage, alimentary tract hemorrhage and abdominal cavity infection, and these measures include nutritional support, careful operation in the surgery with adequate drainage, and careful observation and nursing after the surgery.
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / adverse effects. Postoperative Complications / prevention & control
  • [MeSH-minor] Adult. Aged. China / epidemiology. Common Bile Duct Neoplasms / surgery. Female. Humans. Male. Middle Aged. Pancreatic Fistula / epidemiology. Pancreatic Fistula / etiology. Pancreatic Fistula / prevention & control

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  • (PMID = 15837657.001).
  • [ISSN] 1000-2588
  • [Journal-full-title] Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
  • [ISO-abbreviation] Di Yi Jun Yi Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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26. Jin SG, Chen ZY, Yan LN, Zeng Y, Huang W, Xu N: A rare case of periampullary carcinoma with ectopic ending of Vater's ampulla. World J Gastroenterol; 2009 Oct 7;15(37):4729-31
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  • [Title] A rare case of periampullary carcinoma with ectopic ending of Vater's ampulla.
  • Magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP) showed the ectopic hepatopancreatic ampulla draining into the fourth part of the duodenum adjacent to the duodenojejunal flexure; the irregular morphology of the duodenojejunal flexure likely due to a soft tissue mass.
  • Laparotomy confirmed the presence of the abnormal ampulla of Vater located at the fourth part of the duodenum and a soft tissue tumor about 6 cm x 5 cm x 5 cm with a peduncle adjoining the ampulla.
  • Periampullary carcinoma with ectopic ending of the Vater's ampulla into the fourth part of the duodenum is rather rare.
  • It is worth mentioning that MRCP is useful for demonstrating anomalies and anatomic variants of the biliary tract system and pancreatic duct.
  • [MeSH-major] Adenoma, Villous / diagnosis. Ampulla of Vater / abnormalities. Duodenal Neoplasms / diagnosis

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  • (PMID = 19787838.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2754523
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27. Leffler J, Poloucek P, Krejcí T: [Carcinoma of the pancreatic head and periampular carcinomas. 10-year results of their resection management]. Rozhl Chir; 2005 Dec;84(12):610-6
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  • [Title] [Carcinoma of the pancreatic head and periampular carcinomas. 10-year results of their resection management].
  • [Transliterated title] Karcinom hlavy pankreatu a periampulární karcinomy. Výsledky resekcní lécby za 10 let.
  • INTRODUCTION: Parcial duodenopancreatectomy (DPE) remains the principal treatment method of carcinomas located in the region of the pancreatic head.
  • The study is aimed at patients with histologically confirmed carcinomas of the pancreatic head.
  • The long-term results were assessed in 71 cancer patients - the median survival rate was 18 months following the procedure (1-121 months), depending on the tumor type.
  • [MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 16447582.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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28. Baumhoer D, Riener MO, Zlobec I, Tornillo L, Vogetseder A, Kristiansen G, Dietmaier W, Hartmann A, Wuensch PH, Sessa F, Ruemmele P, Terracciano LM: Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater. Mod Pathol; 2009 Feb;22(2):306-13
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  • [Title] Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater.
  • Carcinomas of the Vaterian system are rare and presumably arise from preexisting adenomas (adenoma-carcinoma-sequence).
  • Usually, biopsies are obtained to confirm and specify endoscopic findings, but differentiating reactive atypia from dysplasia or dysplasia from invasive carcinoma can sometimes be difficult or even impossible on morphological criteria alone.
  • In case of invasive carcinoma, furthermore, the precise classification of carcinoma subtypes needs to be established since the distinct subtypes differ significantly in terms of clinical outcome.
  • We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater.
  • Although the expression of the cell adhesion proteins did not differ between the carcinoma subtypes, marked differences between normal mucosa, adenoma and carcinoma samples were observed.
  • All marker proteins were expressed in less than 7% of normal mucosa samples (S100A4 in only 1% of cases) and showed an increasing expression from adenoma to invasive carcinoma.
  • CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma.
  • [MeSH-major] Adenoma / chemistry. Ampulla of Vater / chemistry. Antigens, CD24 / analysis. Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma / chemistry. Common Bile Duct Neoplasms / chemistry. S100 Proteins / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Europe. Female. Humans. Male. Middle Aged. Mucous Membrane / chemistry. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19043399.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD24; 0 / Biomarkers, Tumor; 0 / CD24 protein, human; 0 / CDH3 protein, human; 0 / Cadherins; 0 / S100 Proteins; 142662-27-9 / S100A4 protein, human
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29. Tang W, Inagaki Y, Kokudo N, Guo Q, Seyama Y, Nakata M, Imamura H, Sano K, Sugawara Y, Makuuchi M: KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression. World J Gastroenterol; 2005 Sep 21;11(35):5450-4
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  • [Title] KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression.
  • AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.
  • METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection.
  • RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases.
  • Staining was not found in the surrounding non-cancer regions of the ampullary tissues.
  • Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes.
  • Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010).
  • CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Antigens / metabolism. Common Bile Duct Neoplasms / metabolism. Glycoproteins / metabolism. Mucins / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, Neoplasm. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin-1

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  • (PMID = 16222735.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens; 0 / Antigens, Neoplasm; 0 / Glycoproteins; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Mucins
  • [Other-IDs] NLM/ PMC4320352
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30. Haddad LB, Scatton O, Randone B, Andraus W, Massault PP, Dousset B, Soubrane O: Pancreatic fistula after pancreaticoduodenectomy: the conservative treatment of choice. HPB (Oxford); 2009 May;11(3):203-9
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  • [Title] Pancreatic fistula after pancreaticoduodenectomy: the conservative treatment of choice.
  • BACKGROUND: A pancreatic fistula (PF) is the most common complication after pancreaticoduodenectomy (PD), and its reported incidence varies from 2% to 28%.
  • The main indications for PD were pancreatic duct carcinoma in 52 patients (44.5%), ampullary carcinoma or adenoma in 18 (15.4%) and islet cell tumour in 11 (9.4%).
  • The medium delay between the pancreatic resection and reoperation was 10 days (range, 3-32 days).

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  • (PMID = 19590648.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2697888
  • [Keywords] NOTNLM ; pancreatic fistula / pancreatic resection / pancreaticoduodenectomy / postoperative complications
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31. Ruemmele P, Dietmaier W, Terracciano L, Tornillo L, Bataille F, Kaiser A, Wuensch PH, Heinmoeller E, Homayounfar K, Luettges J, Kloeppel G, Sessa F, Edmonston TB, Schneider-Stock R, Klinkhammer-Schalke M, Pauer A, Schick S, Hofstaedter F, Baumhoer D, Hartmann A: Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol; 2009 May;33(5):691-704
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  • [Title] Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.
  • The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of the papilla of Vater and their precursor lesions are not well established.
  • We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of MMR proteins and specific histopathologic features.
  • Patients with MSI-H carcinoma had a significantly longer overall survival (P=0.0082) than those with MSI-L or MSS tumors.
  • The MMR deficient molecular pathway of carcinogenesis is associated with a histopathologic phenotype in ampullary cancer, similar to the one that has been well described in colon cancer.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater / pathology. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair. Gene Expression Regulation, Neoplastic. Microsatellite Instability. Precancerous Conditions / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Differentiation. DNA Methylation. DNA-Binding Proteins / genetics. Europe. Female. Gene Deletion. Genotype. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. MutS Homolog 2 Protein / genetics. Neoplasm Invasiveness. Neoplasm Staging. Nuclear Proteins / genetics. Phenotype. Polymerase Chain Reaction. Promoter Regions, Genetic. Proportional Hazards Models. Risk Assessment. Treatment Outcome

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  • (PMID = 19252434.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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32. Tien YW, Yeh CC, Wang SP, Hu RH, Lee PH: Is blind pancreaticoduodenectomy justified for patients with ampullary neoplasms? J Gastrointest Surg; 2009 Sep;13(9):1666-73
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  • [Title] Is blind pancreaticoduodenectomy justified for patients with ampullary neoplasms?
  • BACKGROUND: Many specialists justify pancreaticoduodenectomy (PD) for pancreatic head neoplasms with suspected but unproven malignance (blind-PD).
  • Our aim in this study was to determine whether blind-PD is also justified for ampullary neoplasms.
  • METHODS: We retrospectively reviewed the records of all patients with presumed resectable ampullary neoplasms treated at the National Taiwan University Hospital from 1998 to 2008.
  • RESULTS: Of the 84 patients without a preoperative tissue diagnosis of malignance, 64 had blind-PD and 20 had ampullectomy (AMP) with intraoperative frozen section.
  • Final pathological diagnosis was benign in ten of 64 blind-PD-treated patients.
  • CONCLUSIONS: Our data support a selective use of blind-PD because (1) a significant portion (65%) of benign ampullary neoplasms can be safely and effectively treated by AMP, (2) blind-PD does not treat ampullary cancer at earlier stage, and (3) blind-PD is associated with significantly more complications and significantly longer hospital stay than AMP.
  • However, blind-PD is strongly recommended for patients with large ampullary neoplasms (>3 cm in diameter), with jaundice, or with malignant endoscopic appearance.
  • [MeSH-major] Ampulla of Vater / pathology. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Aged. Biopsy, Needle. Cholangiopancreatography, Endoscopic Retrograde / methods. Cohort Studies. Disease-Free Survival. Female. Follow-Up Studies. Hospital Mortality / trends. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Postoperative Complications / mortality. Preoperative Care. Probability. Registries. Retrospective Studies. Risk Assessment. Sphincterotomy, Endoscopic. Statistics, Nonparametric. Survival Rate

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  • (PMID = 19557483.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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33. Albores-Saavedra J, Hart A, Chablé-Montero F, Henson DE: Carcinoids and high-grade neuroendocrine carcinomas of the ampulla of vater: a comparative analysis of 139 cases from the surveillance, epidemiology, and end results program-a population based study. Arch Pathol Lab Med; 2010 Nov;134(11):1692-6
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  • [Title] Carcinoids and high-grade neuroendocrine carcinomas of the ampulla of vater: a comparative analysis of 139 cases from the surveillance, epidemiology, and end results program-a population based study.
  • CONTEXT: Neuroendocrine tumors of the ampulla of Vater constitute a heterogeneous group of neoplasms clinically and morphologically.
  • OBJECTIVE: To analyze the demographics and the 5- and 10-year relative survival rates of 139 patients with carcinoid tumors and high-grade neuroendocrine carcinomas of the ampulla.
  • DESIGN: Using data from National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program from 1973 to 2006, we analyzed the demographics, morphology, and survival of patients with carcinoids and neuroendocrine carcinomas of the ampulla.
  • RESULTS: SEER recorded 6081 cases of malignant neoplasms of the ampulla, of which 82 were carcinoid tumors and 57 were high-grade neuroendocrine carcinomas.
  • CONCLUSIONS: Carcinoids of the ampulla of Vater are relatively rare.
  • Carcinoids and high-grade neuroendocrine carcinomas of the ampulla are biologically and clinically similar to these tumors arising in other sites.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoid Tumor / epidemiology. Carcinoma, Neuroendocrine / epidemiology. Common Bile Duct Neoplasms / epidemiology

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  • (PMID = 21043824.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Furuse J, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, Kondo S, Saito H, Tsuyuguchi T, Hirata K, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Guidelines for chemotherapy of biliary tract and ampullary carcinomas. J Hepatobiliary Pancreat Surg; 2008;15(1):55-62
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  • [Title] Guidelines for chemotherapy of biliary tract and ampullary carcinomas.
  • Few randomized controlled trials (RCTs) with large numbers of patients have been conducted to date in patients with biliary tract cancer, and standard chemotherapy has not been established yet.
  • In this article we review previous studies and clinical trials regarding chemotherapy for unresectable biliary tract cancer, and we present guidelines for the appropriate use of chemotherapy in patients with biliary tract cancer.
  • Thus, chemotherapy for patients with biliary tract cancer seems to be a significant treatment of choice.
  • However, chemotherapy for patients with biliary tract cancer should be indicated for those with unresectable, locally advanced disease or distant metastasis, or for those with recurrence after resection.
  • That is why making the diagnosis of unresectable disease should be done with greatest care.
  • As a rule, pathological diagnosis, including cytology or histopathological diagnosis, is preferable.
  • As chemotherapy for unresectable biliary tract cancer, the use of gemcitabine or tegafur/gimeracil/oteracil potassium is recommended.
  • [MeSH-major] Ampulla of Vater. Antineoplastic Agents / therapeutic use. Biliary Tract Neoplasms / drug therapy. Carcinoma / drug therapy

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  • (PMID = 18274844.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ PMC2794344
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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35. Barauskas G, Gulbinas A, Pundzius J: Results of surgical treatment of carcinoma of papilla of Vater. Medicina (Kaunas); 2007;43(6):455-62
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  • [Title] Results of surgical treatment of carcinoma of papilla of Vater.
  • Adenocarcinoma is the most common malignant tumor of the ampulla, but in general, it is still rare.
  • To evaluate immediate postoperative and long-term results, we have collected data prospectively in a specially created database on 21 consecutive patients with adenocarcinoma of the papilla of Vater, operated on at the Department of Surgery, Kaunas University of Medicine Hospital.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Prospective Studies. Sex Factors. Time Factors. Treatment Outcome

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  • (PMID = 17637516.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
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36. Singh S, Sachdev AK, Chaudhary A, Agarwal AK: Palliative surgical bypass for unresectable periampullary carcinoma. Hepatobiliary Pancreat Dis Int; 2008 Jun;7(3):308-12
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  • [Title] Palliative surgical bypass for unresectable periampullary carcinoma.
  • BACKGROUND: Around 60% to 80% of patients with periampullary carcinoma are unresectable either due to distant metastasis or local vascular invasion.
  • This study was conducted to assess the results of palliative surgical bypass for patients with unresectable periampullary carcinoma at our hospital, a tertiary referral center of Northern India.
  • METHOD: The study group comprised 204 patients who had undergone surgical bypass for advanced periampullary carcinoma over the last 15 years.
  • RESULTS: Between January 1990 and December 2004, 204 patients (128 males, 76 females) consisting of 179 patients with carcinoma of head of the pancreas, 14 patients with ampullary carcinoma, 8 patients with lower end cholangiocarcinoma and 3 patients with duodenal carcinoma underwent surgical bypass.
  • [MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Gastrostomy / methods. Jejunostomy / methods. Palliative Care / methods
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Treatment Outcome

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  • (PMID = 18522888.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
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37. Zhang XM, Shen CY, Li W, Zhang XM: [Surgical treatment of tumor invading important vessel]. Zhonghua Wai Ke Za Zhi; 2007 Aug 1;45(15):1044-7
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  • The tumor involving thoraco-abdominal cavity was in one case with malignant neuroblastoma.
  • Tumor located in thoracic cavity were in 13 cases including IVC leiomyosarcoma in 2 cases, thymic carcinoma in 3 cases, malignant thymoma in 4 cases, malignant seminoma of superior mediastinum in 1 case, malignant lymphoma in 1 case, lung cancer in 2 cases.
  • The tumor located in abdominal cavity were in 24 cases including renal carcinoma with tumor thrombi in 11 cases, inflammatory pseudotumor of retro-peritoneum in 4 cases, malignant fibrous histiocytoma of retro-peritoneum in 1 case, non-Hodgkin's disease of retro-peritoneum in 1 case, lymph metastasis of retro-peritoneum in 2 cases, paraganglion tumor of the right adrenal gland in 1 case, ampullary carcinoma in 1 case, leiomyosarcoma of abdominal IVC in 1 case, leiomyosarcoma of pelvic cavity and IVC in 1 cases, fibrosarcoma of pelvic cavity in 1 case.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies. Treatment Outcome. Vena Cava, Inferior / pathology. Vena Cava, Inferior / surgery

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  • (PMID = 18005586.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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38. Abdullah SA, Gupta T, Jaafar KA, Chung YF, Ooi LL, Mesenas SJ: Ampullary carcinoma: effect of preoperative biliary drainage on surgical outcome. World J Gastroenterol; 2009 Jun 21;15(23):2908-12
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  • [Title] Ampullary carcinoma: effect of preoperative biliary drainage on surgical outcome.
  • AIM: To evaluate the influence of preoperative biliary drainage on morbidity and mortality after surgical resection for ampullary carcinoma.
  • METHODS: We analyzed retrospectively data for 82 patients who underwent potentially curative surgery for ampullary carcinoma between September 1993 and July 2007 at the Singapore General Hospital, a tertiary referral hospital.
  • Diagnosis of ampullary carcinoma was confirmed histologically.
  • The following parameters were analyzed: wound infection, intra-abdominal abscess, intra-abdominal or gastrointestinal bleeding, septicemia, biliary or pancreatic leakage, pancreatitis, gastroparesis, and re-operation rate.
  • However, the rest of the parameters did not differ significantly between the groups, i.e. sepsis [10 (28.6%) vs 14 (29.8%)], intra-abdominal bleeding [1 (2.9%) vs 5 (10.6%)], intra-abdominal abscess [1 (2.9%) vs 8 (17%)], gastrointestinal bleeding [3 (8.6%) vs 5 (10.6%)], pancreatic leakage [2 (5.7%) vs 3 (6.4%)], biliary leakage [2 (5.7%) vs 3 (6.4%)], pancreatitis [2 (5.7%) vs 2 (4.3%)], gastroparesis [6 (17.1%) vs 10 (21.3%)], need for blood transfusion [10 (28.6%) vs 17 (36.2%)] and re-operation rate [1 (2.9%) vs 5 (10.6%)].
  • CONCLUSION: Biliary drainage before surgery for ampullary cancer significantly reduced postoperative wound infection.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Drainage. Pancreatic Neoplasms / surgery. Preoperative Care

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  • (PMID = 19533815.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2699011
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39. Palanivelu C, Jani K, Senthilnathan P, Parthasarathi R, Rajapandian S, Madhankumar MV: Laparoscopic pancreaticoduodenectomy: technique and outcomes. J Am Coll Surg; 2007 Aug;205(2):222-30
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  • RESULTS: The procedure could be completed laparoscopically with tumor-free margins in all patients, including patients with ampullary carcinoma (n = 24), pancreatic cystadenocarcinoma (n = 4), pancreatic head adenocarcinoma (n = 9), low common bile duct cancer (n = 3), and two patients with chronic pancreatitis with a suspicious mass lesion in the head of pancreas.
  • Five-year actuarial survival rates for all patients with malignancy, ampullary adenocarcinoma, pancreatic cystadenocarcinoma, pancreatic head adenocarcinoma, and common bile duct adenocarcinoma are 32%, 30.7%, 33.3%, 19.1%, and 50%, respectively.
  • Localized malignant lesions, irrespective of histopathology, are particularly amenable to this approach.
  • [MeSH-major] Duodenal Neoplasms / surgery. Laparoscopy. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 17660068.001).
  • [ISSN] 1072-7515
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Brown KM, Tompkins AJ, Yong S, Aranha GV, Shoup M: Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer. Arch Surg; 2005 Jun;140(6):529-32; discussion 532-3
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  • [Title] Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer.
  • HYPOTHESIS: Survival following resection for ampullary carcinoma may be influenced by 1 or more clinical or pathologic variables.
  • PATIENTS: From July 1, 1991, through April 30, 2004, 72 patients (31 males and 41 females) were treated for ampullary carcinoma at Loyola University Medical Center, Maywood, Ill.
  • INTERVENTIONS: Whipple procedure for attempted cure in 51 patients with ampullary adenocarcinoma.
  • CONCLUSION: Pancreaticoduodenectomy is curative in 80% of patients with node-negative ampullary carcinomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater. Blood Loss, Surgical. Female. Humans. Lymph Nodes / pathology. Male. Middle Aged. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome

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  • [CommentIn] Arch Surg. 2005 Jul;140(7):708 [16027340.001]
  • (PMID = 15967899.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Williams KJ, Picus J, Trinkhaus K, Fournier CC, Suresh R, James JS, Tan BR: Gemcitabine with carboplatin for advanced biliary tract cancers: a phase II single institution study. HPB (Oxford); 2010 Aug;12(6):418-26
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  • METHODS: Patients with histologically proven BTCs, including cholangiocarcinoma or gallbladder and ampullary carcinomas, were treated with a maximum of nine cycles of intravenous (i.v.) gemcitabine at 1000 mg/m(2) over 30 min on days 1 and 8 with i.v. carboplatin dosed at an area-under-the-curve (AUC) of 5 over 60 min on day 1 of a 21-day cycle.
  • RESULTS: A total of 48 patients with advanced BTCs (35 cholangiocarcinoma, 12 gallbladder and 1 ampullary cancer) were enrolled.

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  • (PMID = 20662793.001).
  • [ISSN] 1477-2574
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00660140
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
  • [Other-IDs] NLM/ PMC3028583
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42. Zhang JW, Zhao H, Bai XF, Fang Y, Wang CF, Zhao P: [Analysis of risk factors of stress-related ulcer and gastrointestinal hemorrhage after pancreaticoduodenectomy]. Zhonghua Zhong Liu Za Zhi; 2010 Jan;32(1):40-3
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  • METHODS: From May 1999 to July 2007, 285 periampullary cancer patients underwent pancreaticoduodenectomy in our hospital.
  • Pathological examination showed pancreatic cancer in 5 cases, duodenal cancer in 8, common bile duct cancer in 10, ampullary carcinoma in 11, and solid-pseudopapillary tumors in 1.
  • [MeSH-major] Common Bile Duct Neoplasms / complications. Gastrointestinal Hemorrhage / etiology. Pancreatic Neoplasms / complications. Pancreaticoduodenectomy / adverse effects. Peptic Ulcer / etiology
  • [MeSH-minor] Adolescent. Adult. Aged. Alcoholism / complications. Ampulla of Vater. Bilirubin / blood. Duodenal Neoplasms / complications. Duodenal Neoplasms / pathology. Duodenal Neoplasms / surgery. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Prealbumin / metabolism. Retrospective Studies. Risk Factors. Stress, Psychological / complications. Young Adult


43. Gore RM, Shelhamer RP: Biliary tract neoplasms: diagnosis and staging. Cancer Imaging; 2007;7 Spec No A:S15-23
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  • [Title] Biliary tract neoplasms: diagnosis and staging.
  • Most biliary tract neoplasms are malignant and have been traditionally divided into cancers of the gallbladder, the extrahepatic bile ducts, and ampulla of Vater.
  • Although infrequent, bile duct carcinomas and cancer of the gallbladder are not rare.
  • In the United States, an estimated 6000-7000 new cases of carcinoma of the gallbladder and 3000-4000 new cases of carcinoma of the bile ducts are diagnosed annually.
  • Familiarity with the imaging characteristics of gallbladder and bile duct neoplasms is important to expedite the diagnosis and appropriate treatment of patients who often present with non-specific symptoms of right upper quadrant pain, jaundice, and weight loss.
  • [MeSH-major] Biliary Tract Neoplasms / diagnosis. Diagnostic Imaging
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging

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  • (PMID = 17921093.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC2727973
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44. Kawakami H, Zen Y, Kuwatani M, Eto K, Haba S, Yamato H, Shinada K, Kubota K, Asaka M: IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vater's ampulla and the bile duct. J Gastroenterol Hepatol; 2010 Oct;25(10):1648-55
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  • [Title] IgG4-related sclerosing cholangitis and autoimmune pancreatitis: histological assessment of biopsies from Vater's ampulla and the bile duct.
  • The present study was carried out to examine the usefulness of endoscopic biopsies from Vater's ampulla and the bile duct to diagnose IgG4-SC.
  • METHODS: The present study included 29 IgG4-SC patients (26 with both pancreatitis and cholangitis, and 3 with cholangitis only), 6 PSC patients, and 27 pancreatobiliary carcinoma patients.
  • All patients underwent endoscopic biopsies from Vater's ampulla and the common bile duct.
  • RESULTS: For the ampullary and bile duct biopsies, the IgG4-SC samples had a significantly greater number of IgG4-positive plasma cells than the PSC or pancreatobiliary carcinoma specimens.
  • The bile duct biopsy was significantly valuable for IgG4-SC patients with swelling of the pancreatic head.
  • [MeSH-major] Ampulla of Vater / pathology. Autoimmune Diseases / immunology. Biopsy / methods. Cholangitis, Sclerosing / immunology. Common Bile Duct / pathology. Immunoglobulin G / immunology. Pancreatitis / immunology
  • [MeSH-minor] Adult. Aged. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Humans. Middle Aged. Reproducibility of Results. Retrospective Studies

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  • [Copyright] © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
  • (PMID = 20880174.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Immunoglobulin G
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45. Chiche L, Alkofer B, Parienti JJ, Rouleau V, Salamé E, Samama G, Segol P: Usefulness of follow-up after pancreatoduodenectomy for carcinoma of the ampulla of Vater. HPB (Oxford); 2007;9(2):140-5
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  • [Title] Usefulness of follow-up after pancreatoduodenectomy for carcinoma of the ampulla of Vater.
  • BACKGROUND: The prognosis for carcinoma of the ampulla of Vater (CAV) is better than for pancreatic cancer.

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  • (PMID = 18333130.001).
  • [ISSN] 1365-182X
  • [Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association
  • [ISO-abbreviation] HPB (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2020781
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46. Nielsen A, Scarlett CJ, Samra JS, Gill A, Li Y, Allen BJ, Smith RC: Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction. J Gastroenterol Hepatol; 2005 Feb;20(2):256-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction.
  • It was hypothesized that uPA would be overexpressed in highly metastatic pancreatic cancer.
  • The aims of this study were to analyze uPA mRNA expression in pancreatic cancer and to correlate this to the expression of uPA protein and to the stage of the disease.
  • METHODS: Twenty-one pancreatic adenocarcinoma, six ampullary carcinoma and 10 benign mucinous cystadenoma samples, all with adjacent normal tissue, were collected. uPA mRNA was measured using real-time quantitative reverse transcription polymerase chain reaction.
  • Localization of uPA within normal and pancreatic tumor sections was subsequently confirmed using immunohistochemistry.
  • RESULTS: The median and range of the ratios of uPA mRNA measures between tumor tissue and non-involved pancreatic tissue was 17.1 (1.4-653.6) for pancreatic adenocarcinoma (P < 0.001), 3.9 (0.7-7.7) for ampullary carcinoma (P = 0.055) and 1.9 (0.6-5.9) for mucinous cystadenoma tissue (P = 0.052).
  • Immunohistochemistry confirmed that uPA protein was more prevalent in pancreatic adenocarcinoma tissue than in normal tissue and that it was membrane-bound. uPA mRNA expression was significantly associated with poorly differentiated pancreatic cancers (P < 0.05) and positively associated with tumor stage.
  • CONCLUSIONS: These observations suggest that significant overexpression of uPA correlates closely to the rapid progression and invasiveness of pancreatic cancer and that uPA may provide a future therapeutic target for pancreatic cancer treatment.
  • [MeSH-major] Adenocarcinoma / genetics. Pancreatic Neoplasms / genetics. Urokinase-Type Plasminogen Activator / genetics

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  • [Copyright] (c) 2004 Blackwell Publishing Asia Pty Ltd.
  • (PMID = 15683429.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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47. Sakata E, Shirai Y, Yokoyama N, Wakai T, Sakata J, Hatakeyama K: Clinical significance of lymph node micrometastasis in ampullary carcinoma. World J Surg; 2006 Jun;30(6):985-91
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  • [Title] Clinical significance of lymph node micrometastasis in ampullary carcinoma.
  • BACKGROUND: This study aimed to clarify the clinical significance of lymph node micrometastasis in ampullary carcinoma.
  • MATERIALS AND METHODS: Pancreaticoduodenectomy with regional lymphadenectomy was performed for 50 consecutive patients with ampullary carcinoma.
  • CONCLUSIONS: Immunohistochemically detected lymph node micrometastasis indicates intensive lymphatic spread, and thus adversely affects the survival of patients with ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Keratins / analysis. Lymph Node Excision. Lymph Nodes / chemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Pancreaticoduodenectomy. Prognosis. Survival Rate

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  • (PMID = 16736326.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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48. Chen L, Tao SF, Zheng YX: Prognostic significance of vascular endothelial growth factor expression and microvessel density in carcinoma of ampulla of Vater. Hepatogastroenterology; 2006 Jan-Feb;53(67):45-50
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  • [Title] Prognostic significance of vascular endothelial growth factor expression and microvessel density in carcinoma of ampulla of Vater.
  • BACKGROUND/AIMS: To investigate whether the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) are of prognostic significance in ampullary carcinoma.
  • METHODOLOGY: Twenty-two resected tumor specimens from patients with ampullary carcinoma were immunohistochemically stained for VEGF and CD34 (surrogate for vessels) by streptavidin-peroxidase method.
  • CONCLUSIONS: VEGF is positively correlated with MVD in ampullary carcinoma.
  • VEGF and angiogenesis may play an important role in lymph node metastasis and progression of ampullary carcinoma.
  • VEGF and MVD appear to be important prognostic predictor in patients with ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater. Carcinoma / blood supply. Carcinoma / metabolism. Common Bile Duct Neoplasms / blood supply. Common Bile Duct Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis

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  • (PMID = 16506374.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A
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49. Hsu HP, Shan YS, Hsieh YH, Yang TM, Lin PW: Predictors of recurrence after pancreaticoduodenectomy in ampullary cancer: comparison between non-, early and late recurrence. J Formos Med Assoc; 2007 Jun;106(6):432-43
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  • [Title] Predictors of recurrence after pancreaticoduodenectomy in ampullary cancer: comparison between non-, early and late recurrence.
  • BACKGROUND/PURPOSE: Ampullary cancer is one of the periampullary cancers with a better prognosis, but relapse still occurs early in some patients.
  • METHODS: Between January 1989 and March 2006, information was gathered on a total of 127 patients undergoing pancreaticoduodenectomy with regional lymphadenectomy for ampullary cancer at National Cheng Kung University Hospital and Tainan Municipal Hospital.
  • The early and late recurrence patients had higher levels of microscopically (R1) or macroscopically (R2) positive margin of resection and more advanced disease (advanced tumor stage, numbers of lymph nodes involved, lymph node status, pancreatic invasion and TNM stage) than the non-recurrence group.
  • After multivariate analysis, positive resection margin, pancreatic invasion and lymph node involvement were significant predictors for disease recurrence.
  • CONCLUSION: Positive resection margin, pancreatic invasion, and lymph node involvement were found to be predictors for disease recurrence and indicators for postoperative treatment.

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  • (PMID = 17588836.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Singapore
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50. Alsaif F: Pylorus preserving pancreaticoduodenectomy for peri-ampullary carcinoma, is it a good option? Saudi J Gastroenterol; 2010 Apr-Jun;16(2):75-8
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  • [Title] Pylorus preserving pancreaticoduodenectomy for peri-ampullary carcinoma, is it a good option?
  • Pancreaticoduodenectomy (PD) is the standard surgical treatment for resectable peri-ampullary tumors.
  • [MeSH-major] Carcinoma / mortality. Carcinoma / surgery. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods. Pylorus
  • [MeSH-minor] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Anastomosis, Surgical / adverse effects. Anastomosis, Surgical / methods. Blood Loss, Surgical. Blood Transfusion. Female. Follow-Up Studies. Gastric Emptying / physiology. Hospital Mortality / trends. Humans. Intraoperative Complications / mortality. Length of Stay. Male. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Postoperative Complications / mortality. Postoperative Complications / prevention & control. Randomized Controlled Trials as Topic. Survival Analysis. Treatment Outcome

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  • (PMID = 20339174.001).
  • [ISSN] 1998-4049
  • [Journal-full-title] Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • [ISO-abbreviation] Saudi J Gastroenterol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Saudi Arabia
  • [Number-of-references] 36
  • [Other-IDs] NLM/ PMC3016509
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56. Hsu HP, Shan YS, Jin YT, Lai MD, Lin PW: Loss of E-cadherin and beta-catenin is correlated with poor prognosis of ampullary neoplasms. J Surg Oncol; 2010 Apr 1;101(5):356-62
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  • [Title] Loss of E-cadherin and beta-catenin is correlated with poor prognosis of ampullary neoplasms.
  • BACKGROUND AND OBJECTIVES: Distant metastasis resulting from carcinoma cell detachment from the primary tumor involves modification of adhesion molecules.
  • This study was conducted to examine the correlation of E-cadherin/beta-catenin expression with survival and recurrence in ampullary neoplasms.
  • METHODS: Patients with diagnoses of ampullary neoplasms were enrolled in the study.
  • Loss of E-cadherin was associated with pancreatic invasion, recurrence, and poor prognosis.
  • Pancreatic invasion, lymph node involvement, and loss of beta-catenin expression were predictors of disease recurrence.
  • CONCLUSIONS: Loss of the E-cadherin/beta-catenin complex is related to poor prognosis in ampullary cancer.
  • [MeSH-major] Ampulla of Vater. Cadherins / analysis. Common Bile Duct Neoplasms / chemistry. Common Bile Duct Neoplasms / mortality. beta Catenin / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Prognosis

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20119975.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / beta Catenin
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57. Aloysius MM, Hewavisenthi SJ, Bates TE, Rowlands BJ, Lobo DN, Zaitoun AM: Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays. World J Surg; 2010 Sep;34(9):2115-21
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  • METHODS: Immunohistochemical staining for Ki-67 was performed on formalin-fixed pancreatic TMA sections.
  • Expression of Ki-67 was assessed as the percentage of cancer cell nuclei expressing MIB1, MI as the mean percentage of Ki-67 from 10 random high-power fields, and M/V was calculated after standardizing MI for connective tissue volume and microscope parameters in the tumor using established protocols.
  • The median survival for tumors of the pancreaticobiliary subtype (pancreatic ductal adenocarcinoma and cholangiocarcinoma) was 43 months in the group with an M/V score of <20, compared with 18 months for the group with a score > or =20 (P = 0.001).
  • There was no statistically significant difference in survival, based on M/V score, for tumors of the intestinal subtype (ampullary and duodenal adenocarcinoma).
  • [MeSH-major] Ampulla of Vater. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic. Carcinoma, Pancreatic Ductal / metabolism. Cholangiocarcinoma / metabolism. Common Bile Duct Neoplasms / metabolism. Duodenal Neoplasms / metabolism. Ki-67 Antigen / analysis. Mitotic Index. Pancreatic Neoplasms / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Lymphatic Metastasis. Microarray Analysis. Neoplasm Invasiveness

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  • (PMID = 20556608.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Yao HS, Wang Q, Wang WJ, Hu ZQ: Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis. World J Surg; 2008 Sep;32(9):2038-46
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  • [Title] Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis.
  • BACKGROUND: Allogeneic blood transfusion (ABT) containing packed red blood cells (RBCs) has a known immunosuppressive effect that may affect cancer metastases and recurrence.
  • This study examined whether intraoperative allogeneic RBC transfusion is an independent risk factor of adverse outcome in patients with ampullary carcinoma after curative pancreatoduodenectomy.
  • METHODS: The clinical data of 67 patients with carcinoma of the ampulla of Vatar underwent pancreatoduodenectomy between 1999 and 2004 were analyzed, and long-term follow-up visits were made for all patients.
  • For the meta-analysis, all English-language studies regarding blood transfusion from carcinoma of the ampulla of Vatar or ampullary carcinoma and prognostic factors or factors for survival from 1995 to 2007 were reviewed, and contingency tables were constructed from which a summary relative risk was calculated.
  • After multivariate analysis, except for presence of lymph node metastasis (P = 0.023) and pancreatic invasion (P = 0.024), the intraoperative ABT > or =3 units was found to be an independent poor prognostic factor for those with ampullary cancer after curative pancreatoduodenectomy either (relative risk, 2.082; 95% confidence interval (CI), 1.048-4.135; P = 0.036).
  • CONCLUSIONS: The amount of intraoperative ABT is one of the important factors that adversely influenced survival in patients with ampullary cancer after curative pancreatoduodenectomy.
  • [MeSH-major] Ampulla of Vater / surgery. Erythrocyte Transfusion. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Blood Loss, Surgical. Blood Transfusion, Autologous. Chi-Square Distribution. Female. Humans. Intraoperative Care. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models. Risk Factors. Survival Analysis. Treatment Outcome

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  • (PMID = 18584239.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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59. Schirmacher P, Büchler MW: Ampullary adenocarcinoma - differentiation matters. BMC Cancer; 2008;8:251
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  • [Title] Ampullary adenocarcinoma - differentiation matters.
  • This fuels the discussion about maintaining ampullary cancer as a separate entity.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis
  • [MeSH-minor] Biomarkers, Tumor. Cell Differentiation. Diagnosis, Differential. Epithelium / pathology. Humans. Medical Oncology / methods. Prognosis

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  • (PMID = 18761739.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2553420
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60. Takada T: Clinical practice guidelines for the management of biliary tract and ampullary carcinomas. J Hepatobiliary Pancreat Surg; 2008;15(1):1
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  • [Title] Clinical practice guidelines for the management of biliary tract and ampullary carcinomas.
  • [MeSH-major] Ampulla of Vater. Biliary Tract Neoplasms / therapy. Carcinoma / therapy

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  • (PMID = 18274837.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Editorial; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794352
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61. Nagano Y, Sekido H, Matsuoi K, Ohtsuki K, Gorai K, Kunisaki C, Ike H, Imada T, Shimada H: Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy. Hepatogastroenterology; 2005 May-Jun;52(63):933-5
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  • [Title] Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy.
  • Duodenoscopy was performed and showed the protruded lesion of the ampulla of Vater, biopsied specimens from this tumor revealed adenocarcinomas.
  • Double cancer of the ampulla of Vater and the esophagus are extremely rare, with only 4 cases reported.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Gastrectomy. Gastric Stump / surgery. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy. Postoperative Complications / surgery
  • [MeSH-minor] Adenoma / surgery. Humans. Lymph Node Excision. Middle Aged. Neoplasm Invasiveness. Reoperation. Stomach Neoplasms / surgery

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  • (PMID = 15966235.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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62. Santini D, Tonini G, Vecchio FM, Borzomati D, Vincenzi B, Valeri S, Antinori A, Castri F, Coppola R, Magistrelli P, Nuzzo G, Picciocchi A: Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma. J Clin Pathol; 2005 Feb;58(2):159-65
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  • [Title] Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma.
  • BACKGROUND: There is a lack of data in the literature concerning the identification of potential prognostic factors in ampullary adenocarcinoma.
  • AIMS: To examine the prognostic significance of Bax, Bcl-2, and p53 protein expression and the apoptotic index in a large cohort of uniformly treated patients with radically resected ampullary cancer.
  • METHODS: All patients with a pathological diagnosis of ampullary cancer and radical resection were evaluated.
  • RESULTS: Thirty nine tumour specimens from patients with radically resected ampullary adenocarcinoma were studied.
  • CONCLUSIONS: These results provide evidence that apoptosis may be an important prognostic factor in patients with radically resected ampullary cancer.
  • This study is the first to assess the clinical usefulness of Bax expression in radically resected ampullary cancer.
  • [MeSH-major] Adenocarcinoma / chemistry. Ampulla of Vater. Common Bile Duct Neoplasms / chemistry. In Situ Nick-End Labeling / methods. Proto-Oncogene Proteins c-bcl-2 / analysis. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 15677536.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
  • [Other-IDs] NLM/ PMC1770581
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63. Shiba H, Misawa T, Wakiyama S, Iida T, Ishida Y, Yanaga K: Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case. J Gastrointest Cancer; 2010 Jun;41(2):138-40
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  • [Title] Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case.
  • CASE REPORT: A 30-year-old woman was admitted to our hospital for treatment of an ampullary tumor.
  • Upper gastrointestinal endoscopy revealed a pedunculated tumor in the ampulla of Vater with a diameter of 50 mm, which was biopsied and diagnosed as tubulovillous adenoma with moderate atypia.
  • DISCUSSION: Ampullectomy is an established method for ampullary tumor, but such a tumor with a long stalk is rare.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 20012229.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Ota Y, Kikuyama M, Sasada Y, Matsuhashi T, Nakahodo J, Yamao K, Shirafuji T: Encoscopic management of stenotic anastomosis using a rendezvous technique after pancreatogastrostomy. Dig Endosc; 2009 Jul;21(3):201-4
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  • She had undergone pylorus-preserving pancreatoduodenectomy due to duodenal carcinoma of the papilla of Vater 5 years before referral.
  • An endoscopic ultrasound (EUS)-guided rendezvous technique was selected to puncture the main pancreatic duct via a transgastric approach.
  • We identified the dilated main pancreatic duct with a convex array echoendoscope from the lower gastric body near the anastomosis and successfully punctured the dilated main pancreatic duct.
  • [MeSH-major] Ampulla of Vater. Anastomosis, Surgical / adverse effects. Common Bile Duct Neoplasms / surgery. Pancreas / surgery. Pancreaticoduodenectomy / adverse effects. Pancreatitis / therapy. Stomach / surgery

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  • (PMID = 19691771.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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65. Bohnacker S, Seitz U, Nguyen D, Thonke F, Seewald S, deWeerth A, Ponnudurai R, Omar S, Soehendra N: Endoscopic resection of benign tumors of the duodenal papilla without and with intraductal growth. Gastrointest Endosc; 2005 Oct;62(4):551-60
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  • [Title] Endoscopic resection of benign tumors of the duodenal papilla without and with intraductal growth.
  • A 7F stent was placed in the pancreatic duct.
  • Nine patients had invasive carcinoma (8%).
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods

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  • [CommentIn] Gastrointest Endosc. 2006 Apr;63(4):737; author reply 737-8 [16564901.001]
  • (PMID = 16185970.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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66. Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, Roughton M, Bridgewater J, ABC-02 Trial Investigators: Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med; 2010 Apr 8;362(14):1273-81
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  • [Title] Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
  • BACKGROUND: There is no established standard chemotherapy for patients with locally advanced or metastatic biliary tract cancer.
  • METHODS: We randomly assigned 410 patients with locally advanced or metastatic cholangiocarcinoma, gallbladder cancer, or ampullary cancer to receive either cisplatin (25 mg per square meter of body-surface area) followed by gemcitabine (1000 mg per square meter on days 1 and 8, every 3 weeks for eight cycles) or gemcitabine alone (1000 mg per square meter on days 1, 8, and 15, every 4 weeks for six cycles) for up to 24 weeks.
  • Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary cancer. (ClinicalTrials.gov number, NCT00262769. )

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  • [Copyright] 2010 Massachusetts Medical Society
  • [CommentIn] Z Gastroenterol. 2010 Aug;48(8):850-1 [20687022.001]
  • [CommentIn] N Engl J Med. 2010 Apr 8;362(14):1335-7 [20375411.001]
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  • (PMID = 20375404.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00262769
  • [Grant] United Kingdom / Cancer Research UK / /
  • [Publication-type] Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
  • [Investigator] Nicholson M; Corrie P; Eatock M; Falk S; Elyan S; Valle J; Anthony A; Nicoll J; Kulkarni R; Osbourne R; Garcia Alonso A; Wasan H; Waters J; Harrison M; Adamson D; Rees C; Bridgewater J; Madhusudan S; McAdam K; Bridgewater J; Maraveyas A; Palmer D; Hickish T; Meyer T; Cunningham D; Iveson T; Middleton G; Slater S; Lofts F; Archer C; Iveson T; Iveson T; Bridgewater J; Mukherjee S; Wadsley J; Gollins S
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67. Balsells-Valls J, Olsina-Kissler JJ, Bilbao-Aguirre I, Solans-Doménech A, Margarit-Creixell C, Armengol-Carrasco M: [Surgical treatment of pancreatic and periampullary carcinoma in a specialized unit: a decade later]. Gastroenterol Hepatol; 2006 Feb;29(2):66-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical treatment of pancreatic and periampullary carcinoma in a specialized unit: a decade later].
  • [Transliterated title] Tratamiento quirúrgico de la neoplasia de páncreas y región periampular en una unidad especializada: una década después.
  • INTRODUCTION: Results of surgical treatment for pancreatic and periampullary carcinoma have improved in recent years owing to several factors, particularly the concentration of these patients in specialised surgical units.
  • MATERIAL AND METHODS: Retrospective-prospective comparative study of results in 2 groups of patients treated over 2 different periods of time and with different surgical policy: group A, which included 80 patients treated from 1982 to 1992 in a general surgery unit, and group B, which comprised 151 patients treated from 1998 to 2003 in a specialised hepato-biliary-pancreatic surgery unit.
  • CONCLUSIONS: Pancreatic and periampullary carcinoma should be surgically treated in specialised pancreatic surgery units in order to offer the best outcome to patients.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 16448606.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Spain
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68. Komatsu S, Sonoyama T, Ochiai T, Ichikawa D, Ikoma H, Okamura H, Otsuji E: Long-term complete response of multiple hepatic metastases from carcinoma of the papilla of Vater using intrahepatic infusion of 5-FU with low-dose cisplatin following pancreaticoduodenectomy. Int J Clin Oncol; 2008 Dec;13(6):567-70
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  • [Title] Long-term complete response of multiple hepatic metastases from carcinoma of the papilla of Vater using intrahepatic infusion of 5-FU with low-dose cisplatin following pancreaticoduodenectomy.
  • Of all distant metastases from carcinoma of the papilla of Vater (CPV), the liver is the most frequent site (more than 60%) and should be specifically targeted in the effort to improve the prognosis.
  • [MeSH-major] Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Pancreaticoduodenectomy

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  • (PMID = 19093189.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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69. Stănciulea O, Preda C, Herlea V, Popa M, Ulmeanu D, Vasilescu C: [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis]. Chirurgia (Bucur); 2007 Mar-Apr;102(2):215-20
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  • [Title] [Rare indication of cephalic duodenopancreatectomy with total gastrectomy--periampullary carcinoma in moderate form of familial adenomatous polyposis].
  • [Transliterated title] Indicaţie rară de duodenopancreatectomie cefalică cu gastrectomie totală-- adenocarcinom periampular cu polipoză adenomatoasă familială forma atenuată.
  • The patient underwent transverse colectomy (the histopathological exam--in situ carcinoma).
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Carcinoma / surgery. Duodenal Neoplasms / surgery. Gastrectomy. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Ampulla of Vater. Humans. Male. Middle Aged. Stomach Neoplasms / surgery. Treatment Outcome


70. Fu H, Gao MK, Qu XL, Sun GF, Shen L: [Periampullary carcinoma with situs inversus totalis: case report and review of the literature]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Mar;10(2):134-7
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  • [Title] [Periampullary carcinoma with situs inversus totalis: case report and review of the literature].
  • OBJECTIVE: To explore the diagnosis and surgical treatment of patients with periampullary carcinoma and situs inversus totalis.
  • METHODS: The data of a patient with periampullary carcinoma and complete situs inversus totalis, a rare disease treated in our hospital on Mar.
  • RESULTS: This patient was diagnosed with stage I to II of periampullary carcinoma.
  • From 1936 to 2006, 15 malignant tumors with situs viscerum inversus totalis were reported, only 5 periampullary carcinomas with situs viscerum inversus totalis were reported.
  • CONCLUSIONS: Surgical operation should be considered for malignant tumor patients with situs inversus totalis without contraindication.
  • [MeSH-major] Ampulla of Vater. Duodenal Neoplasms / complications. Situs Inversus / complications
  • [MeSH-minor] Humans. Middle Aged. Pancreatic Neoplasms / complications

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  • (PMID = 17380452.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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71. Kim YK, Han YM, Kim CS: Usefulness of fat-suppressed T1-weighted MRI using orally administered superparamagnetic iron oxide for revealing ampullary carcinomas. J Comput Assist Tomogr; 2007 Jul-Aug;31(4):519-25
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  • [Title] Usefulness of fat-suppressed T1-weighted MRI using orally administered superparamagnetic iron oxide for revealing ampullary carcinomas.
  • OBJECTIVE: To evaluate the value of adding fat-suppressed (FS) T1-weighted magnetic resonance imaging (MRI) with orally administered superparamagnetic iron oxide (SPIO) to the 3-dimensional dynamic MRI for revealing ampullary carcinomas.
  • MATERIALS: Twenty-five patients with ampullary carcinoma who underwent MRI with orally administered SPIO, including a FS T1-weighted fast low-angle shot (FLASH) sequence, a respiratory-triggered turbo spin-echo (RT-TSE) sequence, and the 3-phasic 3-dimensional dynamic images, were enrolled in this study.
  • CONCLUSIONS: Addition of the FS FLASH image using orally administered SPIO to the dynamic MRI is useful for revealing ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Contrast Media. Ferric Compounds. Image Enhancement / methods. Magnetic Resonance Imaging / methods

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  • (PMID = 17882025.001).
  • [ISSN] 0363-8715
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 1K09F3G675 / ferric oxide
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72. Hao CY, Su XQ, Ji JF, Huang XF, Xing BC: Stomach-interposed cholecystogastrojejunostomy: a palliative approach for periampullary carcinoma. World J Gastroenterol; 2005 Apr 7;11(13):2009-12
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  • [Title] Stomach-interposed cholecystogastrojejunostomy: a palliative approach for periampullary carcinoma.
  • AIM: For patients of periampullary carcinoma found to be unresectable at the time of laparotomy, surgical palliation is the primary choice of treatment.
  • [MeSH-minor] Aged. Ampulla of Vater / pathology. Humans. Laparotomy / methods. Middle Aged. Retrospective Studies

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  • (PMID = 15800996.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4305727
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73. Milson A, Abdellaoui A, Fraser C, Watkinson AF: Transhepatic assisted transoral placement of a duodenal stent in malignant gastric outlet obstruction. J Vasc Interv Radiol; 2010 Apr;21(4):590-2
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  • [Title] Transhepatic assisted transoral placement of a duodenal stent in malignant gastric outlet obstruction.
  • Gastric outlet obstruction is a well- recognized complication of locally advanced carcinoma of the head of the pancreas.
  • The authors report a transoral placement of a duodenal stent over a percutaneous guide wire, inserted retrogradely through a transhepatic approach via the ampulla of Vater, in a patient in whom traditional stent placement was technically not possible.
  • This technique allows safe duodenal stent placement for different malignant gastric outlet obstruction such as pancreatic, gastric, duodenal, and metastases to the peripancreatic region.
  • [MeSH-major] Gastric Outlet Obstruction / etiology. Gastric Outlet Obstruction / therapy. Liver / surgery. Mouth. Pancreatic Neoplasms / complications. Prosthesis Implantation / methods. Stents

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  • [Copyright] Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20149689.001).
  • [ISSN] 1535-7732
  • [Journal-full-title] Journal of vascular and interventional radiology : JVIR
  • [ISO-abbreviation] J Vasc Interv Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Imazu H, Uchiyama Y, Matsunaga K, Ikeda K, Kakutani H, Sasaki Y, Sumiyama K, Ang TL, Omar S, Tajiri H: Contrast-enhanced harmonic EUS with novel ultrasonographic contrast (Sonazoid) in the preoperative T-staging for pancreaticobiliary malignancies. Scand J Gastroenterol; 2010 Jun;45(6):732-8
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  • The final diagnosis were pancreatic cancer in 11, bile duct cancer in 7, gallbladder cancer in 4 and ampullary cancer in 4.
  • CH-EUS staged correctly in all of these six cases, whereas H-EUS misdiagnosed the depth of invasion in one case of gallbladder cancer and one case of ampullary cancer, and invasion of portal vein in two cases of pancreatic cancer and two cases of bile duct cancer.
  • CONCLUSION: The depth of invasion of biliary cancer and vascular invasion of pancreatic and biliary cancer could be demonstrated more clearly with CH-EUS compared to H-EUS.
  • [MeSH-major] Biliary Tract Neoplasms / ultrasonography. Contrast Media / administration & dosage. Endosonography / methods. Ferric Compounds. Iron. Neoplasm Staging / methods. Oxides. Pancreatic Neoplasms / ultrasonography
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Injections, Intravenous. Pilot Projects. Preoperative Period. Prospective Studies. Reproducibility of Results

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  • (PMID = 20205504.001).
  • [ISSN] 1502-7708
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Ferric Compounds; 0 / Oxides; 0 / Sonazoid; E1UOL152H7 / Iron
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75. Foo FJ, Gill U, Verbeke CS, Guthrie JA, Menon KV: Ampullary carcinoma associated with an annular pancreas. JOP; 2007;8(1):50-4
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  • [Title] Ampullary carcinoma associated with an annular pancreas.
  • CASE REPORT: We present a case report of a 78-year-old woman with jaundice due to an ampullary carcinoma associated with an annular pancreas treated by pancreaticoduodenectomy.
  • [MeSH-minor] Aged. Ampulla of Vater / surgery. Female. Humans. Pancreaticoduodenectomy

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  • (PMID = 17228134.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 21
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76. Wasan SM, Ross WA, Staerkel GA, Lee JH: Use of expandable metallic biliary stents in resectable pancreatic cancer. Am J Gastroenterol; 2005 Sep;100(9):2056-61
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  • [Title] Use of expandable metallic biliary stents in resectable pancreatic cancer.
  • AIM: To compare the efficacy of metal versus plastic stents for biliary strictures in patients with surgically resectable pancreatic cancer.
  • Of the 12 patients with pancreaticoduodenectomy, 10 had pancreatic adenocarcinoma, 1 intraductal papillary mucinous tumor, and 1 ampullary cancer.
  • Of the 35 patients, 27 had pancreatic adenocarcinoma, 5 ampullary cancer, 1 neuroendocrine tumor, 1 microcystic adenoma, and 1 autoimmune pancreatitis.
  • CONCLUSIONS: Contrary to the belief that metal stents are contraindicated for patients with surgically resectable pancreatic cancer, our study demonstrated that metal stents provided a longer patency rate, fewer ERCP sessions, and fewer episodes of cholangitis without adding any intra- or postoperative complications.
  • Therefore, metal stents should be considered for patients with resectable pancreatic cancer, especially if surgery is not immediately planned as more patients are now receiving preoperative chemoradiation.
  • [MeSH-major] Pancreatic Neoplasms / surgery. Pancreatic Neoplasms / therapy. Stents

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  • (PMID = 16128952.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metals; 0 / Plastics
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77. Gandini R, Fabiano S, Pipitone V, Spinelli A, Reale CA, Colangelo V, Pampana E, Romagnoli A, Simonetti G: Management of biliary neoplastic obstruction with two different metallic stents implanted in one session. Cardiovasc Intervent Radiol; 2005 Jan-Feb;28(1):48-52
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  • The efficacy of the "one-step" technique using two different metallic stents (Wallstent and Ultraflex) and associated rate of complications was studied in 87 patients with jaundice secondary to malignant biliary obstruction, with bilirubin level less than 15 mg/dl and Bismuth type 1 or 2 strictures.
  • The cause of the obstruction was pancreatic carcinoma in 38 patients (44%), lymph node metastasis in 20 patients (23%), gallbladder carcinoma in 13 patients (15%), cholangiocarcinoma in 12 patients (14%) and ampullary carcinoma in four patients (5%).

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  • (PMID = 15772722.001).
  • [ISSN] 0174-1551
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Lee EJ, Joo KR, Cha JM, Shin HP, Jung SW, Lee JI, Kim GY: Intra-ampullary protruding mass: unusual presentation of mucinous carcinoma of the pancreas. Endoscopy; 2009;41 Suppl 2:E74-5
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  • [Title] Intra-ampullary protruding mass: unusual presentation of mucinous carcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / secondary. Pancreatic Neoplasms / pathology

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  • (PMID = 19370519.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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79. Kala Z, Weber P, Hemmelová B, Marek F, Hlavsa J, Sobotka M: Ampullary tumours (ampullomas) in the elderly--an interdisciplinary problem. Indian J Med Res; 2010 Mar;131:418-21
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  • [Title] Ampullary tumours (ampullomas) in the elderly--an interdisciplinary problem.
  • BACKGROUND & OBJECTIVES: Ampullary cancer is one of the periampullary tumours with better prognosis, but relapses occur early in some patients.
  • METHODS: Between 2005 and 2007, 19 patients (12 male, 7 female) aged over 65 yr (range 66 and 83 yr) with diagnosis of ampulloma were operated.
  • RESULTS: Of the 19 patients, 6 underwent local surgical ampullectomy with reinsertion of ductus choledochus and Wirsungi's duct for benign or early cancer lesion and 13 underwent PDE (Whipple operation).
  • INTERPRETATION & CONCLUSIONS: Diagnosis and therapy of ampullary tumours is multimodal.
  • [MeSH-major] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Common Bile Duct Diseases / diagnosis. Common Bile Duct Diseases / therapy. Common Bile Duct Neoplasms / surgery

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  • (PMID = 20418556.001).
  • [ISSN] 0971-5916
  • [Journal-full-title] The Indian journal of medical research
  • [ISO-abbreviation] Indian J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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80. Corbo V, Ritelli R, Barbi S, Funel N, Campani D, Bardelli A, Scarpa A: Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas. PLoS One; 2010;5(9):e12653
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  • [Title] Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.
  • METHODOLOGY/PRINCIPAL FINDINGS: We conducted a DNA-sequence analysis of a selected set of 35 kinase genes in a panel of 52 pancreatic exocrine neoplasms, including 36 pancreatic ductal adenocarcinoma, and 16 ampulla of Vater cancer.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / genetics. Common Bile Duct Neoplasms / genetics. Mutation. Pancreatic Neoplasms / genetics. Protein Kinases / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater / enzymology. Base Sequence. Cell Line, Tumor. Female. Humans. Male. Middle Aged. Molecular Sequence Data


81. Lien HC, Lu YS, Shun CT, Yao YT, Chang WC, Cheng AL: Differential expression of glucocorticoid receptor in carcinomas of the human digestive system. Histopathology; 2008 Feb;52(3):314-24
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  • GR expression was strong in oesophageal squamous epithelia, pancreatic islet cells and hepatocytes, but generally weak or negative in non-squamous epithelia.
  • [MeSH-major] Adenocarcinoma / metabolism. Biomarkers, Tumor / metabolism. Carcinoma, Basosquamous / metabolism. Carcinoma, Squamous Cell / metabolism. Digestive System Neoplasms / metabolism. Receptors, Glucocorticoid / metabolism
  • [MeSH-minor] Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Antineoplastic Combined Chemotherapy Protocols / pharmacology. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Cell Line, Tumor. Cell Survival / drug effects. Cholangiocarcinoma / metabolism. Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. DNA, Neoplasm / analysis. Dexamethasone / pharmacology. Drug Resistance, Neoplasm / drug effects. Humans. Immunoenzyme Techniques. Sequence Analysis, DNA. Survival Rate

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  • (PMID = 18269582.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Receptors, Glucocorticoid; 7S5I7G3JQL / Dexamethasone
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82. Chen WX, Xie QG, Zhang WF, Zhang X, Hu TT, Xu P, Gu ZY: Multiple imaging techniques in the diagnosis of ampullary carcinoma. Hepatobiliary Pancreat Dis Int; 2008 Dec;7(6):649-53
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  • [Title] Multiple imaging techniques in the diagnosis of ampullary carcinoma.
  • BACKGROUND: Ampullary carcinoma is a neoplasia with a good prognosis compared to pancreatic cancer.
  • This study aimed to evaluate the efficacy of abdominal ultrasonography (US), enhanced computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) in detecting ampullary carcinoma.
  • METHODS: Forty-one patients with ampullary carcinoma who had been confirmed pathologically among the inpatients at the First Affiliated Hospital of Zhejiang University School of Medicine from February 2003 to March 2007 were analyzed retrospectively.
  • The accuracy of US, CT, MRCP and ERCP were compared in the diagnosis of ampullary carcinoma.
  • RESULTS: The accurate rate for detection of ampullary carcinoma with US was 26.83%.
  • The accuracy of CT and ERCP in detection of ampullary tumors was 84.62% and 100%, respectively, which were significantly higher than that of US (P<0.05).
  • The accuracy of MRCP in detection of ampullary tumors was similar to that of US in spite of visualization of obstruction and dilatation of the pancreaticobiliary duct with MRCP.
  • CONCLUSIONS: Because of the obscure and late onset of symptoms, ampullary carcinoma is difficult to diagnose early.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Papillary / diagnosis. Bile Duct Neoplasms / diagnosis. Diagnostic Techniques, Digestive System / standards
  • [MeSH-minor] Adult. Aged. Ampulla of Vater. Cholangiopancreatography, Endoscopic Retrograde / standards. Diagnosis, Differential. Early Diagnosis. Humans. Magnetic Resonance Imaging / standards. Middle Aged. Prognosis. Reproducibility of Results. Retrospective Studies. Tomography, X-Ray Computed / standards. Ultrasonography / standards

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  • (PMID = 19073413.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Validation Studies
  • [Publication-country] China
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83. Sato Y, Ohwada S, Oyama T, Kashiwabara K, Totsuka O, Yamada T, Morishita Y: Ampullary carcinoma associated with protein-losing gastropathy due to diffuse varioliform gastritis. Hepatogastroenterology; 2005 Jul-Aug;52(64):1143-6
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  • [Title] Ampullary carcinoma associated with protein-losing gastropathy due to diffuse varioliform gastritis.
  • Protein-losing gastropathy due to diffuse varioliform gastritis is a rare condition, and its occurrence accompanying ampullary carcinoma is particularly rare.
  • We report here a case of ampullary carcinoma accompanied with protein-losing gastroenteropathy due to diffuse varioliform gastritis.
  • Upper gastrointestinal endoscopic examination showed diffuse varioliform gastritis and carcinoma of the papilla of Vater.
  • A diagnosis of protein-losing gastropathy was made based on the results of scintigraphy using technetium 99m-labeled human albumin.
  • Continuous bleeding from ampullary carcinoma caused anemia and deteriorated hypoproteinemia.
  • Pancreaticoduodenectomy was performed for ampullary carcinoma prior to Helicobacter pylori eradication.
  • [MeSH-major] Adenocarcinoma, Papillary / complications. Ampulla of Vater. Common Bile Duct Neoplasms / complications. Gastritis, Hypertrophic / pathology. Protein-Losing Enteropathies / etiology
  • [MeSH-minor] Adult. Female. Helicobacter Infections / diagnosis. Helicobacter Infections / therapy. Helicobacter pylori. Humans. Pancreaticoduodenectomy

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  • (PMID = 16001648.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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84. Teo M, Ryan B, Swan N, McDermott RS: A Case of Metastatic Renal Cell Cancer Presenting as Jaundice. World J Oncol; 2010 Oct;1(5):218-220
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  • [Title] A Case of Metastatic Renal Cell Cancer Presenting as Jaundice.
  • Renal cell carcinoma is the second most common urological malignancy and it runs a highly variable clinical course.
  • We describe a case of metastatic renal cell carcinoma in a 50-year-old lady with metastasis to the ampulla of Vater, clinically masquerading as cholelithiasis and biliary colic.
  • Ampullary metastases are rare, and prompt recognition and intervention are necessary before patient's performance status is compromised.

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  • (PMID = 29147211.001).
  • [ISSN] 1920-454X
  • [Journal-full-title] World journal of oncology
  • [ISO-abbreviation] World J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Complication / Kidney cancer / Metastasis
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85. Westphalen AC, Coakley FV, Joe BN: Radiological reasoning: 88-year-old man with abdominal pain and dilated biliary tree and pancreatic duct. AJR Am J Roentgenol; 2010 Jun;194(6 Suppl):S46-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiological reasoning: 88-year-old man with abdominal pain and dilated biliary tree and pancreatic duct.
  • [MeSH-major] Abdominal Pain / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Carcinoma, Pancreatic Ductal / diagnosis. Carcinoma, Papillary / diagnosis. Pancreatic Neoplasms / diagnosis. Pneumonia / diagnosis
  • [MeSH-minor] Aged, 80 and over. Ampulla of Vater / pathology. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Dilatation, Pathologic. Endoscopy, Gastrointestinal. Endosonography. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 20489116.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Case Reports; Clinical Conference; Journal Article
  • [Publication-country] United States
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86. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Signet-ring cell carcinoma of the ampulla of Vater: report of a case. Surg Today; 2007;37(12):1110-4
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  • [Title] Signet-ring cell carcinoma of the ampulla of Vater: report of a case.
  • Signet-ring cell carcinoma (SRCC) of the ampulla of Vater is uncommon, and only 13 cases have been previously described.
  • We herein report a rare case of a 43-year-old woman with SRCC in the ampulla of Vater.
  • Although this histologic type of cancer generally predicts a poor prognosis elsewhere in the gastrointestinal tract, the present patient has survived with no evidence of recurrence for 7.5 years.
  • She underwent a pancreaticoduodenectomy with an extended lymphadenectomy for ampullary carcinoma.
  • This neoplasm was classified as AcdbBi, 2.0 x 1.8 cm, ulcerative type, Panc(0), Du(2), T(2)N(0)M(-), Stage II according to the Japanese Classification on Cancer of the Biliary Tract.
  • Unfortunately, previous reports of ampullary SRCC have been limited to short-term follow-ups with a median period of only 12 months (range, 6-134 months), and long-term survival (more than 5 years) was only documented in two cases without lymph node metastasis (including the present case).
  • In conclusion, the experience gained in the present and previous cases suggests that long-term survival is possible following a curative resection in selected patients with ampullary SRCC without nodal involvement.
  • Due to the lack of sufficient evidence, additional reports are warranted to determine whether SRCC also portends a poor prognosis in patients with ampullary cancer.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Signet Ring Cell / pathology. Common Bile Duct Neoplasms / pathology. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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  • (PMID = 18030577.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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87. Song HG, Yoo KS, Ju NR, Park JC, Jung JO, Shin WG, Moon JH, Kim JP, Kim KO, Park CH, Hahn T, Park SH, Kim JH, Lee IJ, Min SK, Park CK: [A case of adenosquamous carcinoma of the papilla of Vater]. Korean J Gastroenterol; 2006 Aug;48(2):132-6
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  • [Title] [A case of adenosquamous carcinoma of the papilla of Vater].
  • Adenosquamous carcinoma of the papilla of Vater is a rare tumor and only a few cases have been reported so far.
  • Here, we report a case of adenosquamous carcinoma in a 76-year-old male who presented with jaundice and right upper quadrant abdominal pain.
  • On endoscopy, obstructing and ulcerated mass was noted on the papilla of Vater.
  • Histopathological inspection of the biopsied specimens from mass showed adenosquamous cell carcinoma of the papilla of Vater.
  • This is the first case report on adenosquamous carcinoma of the papilla of Vater in Korea.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma, Adenosquamous / diagnosis

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  • (PMID = 16929159.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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88. Venizelos I, Tamiolakis D, Petrakis G: Primary combined carcinoid and adenocarcinoma of the ileum associated with transitional carcinoma of the bladder. Single case report. Rev Esp Enferm Dig; 2007 Mar;99(3):145-8
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  • [Title] Primary combined carcinoid and adenocarcinoma of the ileum associated with transitional carcinoma of the bladder. Single case report.
  • Composite neoplasms, carcinoid and adenocarcinoma have been reported to occur in several parts of the body, including the stomach, ampulla of Vater, large bowel, lung, and urinary bladder.
  • Here we report a case of a 74-year-old male with a composite carcinoid-adenocarcinoma of the ileum associated with a transitional cell carcinoma of the bladder.
  • A review of the literature revealed that this is the first reported case of composite carcinoid-adenocarcinoma of the ileum associated with transitional cell carcinoma of the urinary bladder.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoid Tumor / pathology. Carcinoma, Transitional Cell / pathology. Ileal Neoplasms / pathology. Urinary Bladder Neoplasms / pathology

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  • [ErratumIn] Rev Esp Enferm Dig. 2007 Nov;99(11):682. Venizelos, I D [corrected to Venizelos, I]; Lambropoulou, M [removed]; Constantinidis, T [removed]; Alexiadis, G [removed]; Papadopoulos, N [removed]
  • (PMID = 17516827.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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89. Srinarmwong C, Luechakiettisak P, Prasitvilai W: Standard whipple's operation versus pylorus preserving pancreaticoduodenectomy: a randomized controlled trial study. J Med Assoc Thai; 2008 May;91(5):693-8
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  • MATERIAL AND METHOD: Between January 2000 and December 2004, 27 patients with pancreatic or periampullary adenocarcinoma were enrolled into the study.
  • Both surgical procedures were equally effective for the treatment of pancreatic and periampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / methods. Perioperative Care. Pylorus / surgery

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  • (PMID = 18672634.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial
  • [Publication-country] Thailand
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90. Kim SC, Kim SH, Myung SJ, Choi JW, Song MH, Jo YJ, Park YS, Joo JE, Park SW: [A case of intraductal papillary mucinous neoplasm of the pancreas arising from pancreas divisum without ventral pancreatic duct of Wirsung]. Korean J Gastroenterol; 2006 Mar;47(3):218-23
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  • [Title] [A case of intraductal papillary mucinous neoplasm of the pancreas arising from pancreas divisum without ventral pancreatic duct of Wirsung].
  • On endoscopic retrograde cholangiopancreatography, there was a severely bulging ampulla of Vater and patulous minor papilla draining mucinous material and a cystic lesion communicating with the dilated Santorini's duct without any communication with Wirsung's duct.
  • Herein, we report a case of invasive IPMN arising from pancreatic head without ventral pancreatic duct with a review of the relevant literatures.
  • [MeSH-major] Carcinoma, Pancreatic Ductal. Pancreas / abnormalities. Pancreatic Ducts / abnormalities. Pancreatic Neoplasms

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  • (PMID = 16554676.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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91. Kamisawa T, Tu Y, Nakajima H, Egawa N, Tsuruta K, Okamoto A: Usefulness of biopsying the major duodenal papilla to diagnose autoimmune pancreatitis: a prospective study using IgG4-immunostaining. World J Gastroenterol; 2006 Apr 7;12(13):2031-3
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  • [Title] Usefulness of biopsying the major duodenal papilla to diagnose autoimmune pancreatitis: a prospective study using IgG4-immunostaining.
  • AIM: To examine the histological and immunohistochemical findings of biopsy specimens taken from the major duodenal papilla of autoimmune pancreatitis (AIP) patients.
  • METHODS: The major duodenal papilla in the resected pancreas of 3 patients with AIP and of 5 control patients [pancreatic carcinoma (n = 3) and chronic alcoholic pancreatitis (n = 2)] was immunostained using anti-CD4-T cell, CD8-T cell and IgG4 antibodies.
  • Forceps biopsy specimens taken from the major duodenal papilla of 2 patients with AIP and 5 control patients with suspected papillitis were prospectively taken during duodenoscopy and immunohistochemically examined.
  • RESULTS: Moderate or severe lymphoplasmacytic infiltration including many CD4-positive or CD8-positive T lymphocytes and IgG4-positive plasma cells (>or=10/HPF), was observed in the major duodenal papilla of all 3 patients with AIP.
  • The same findings were also detected in the biopsy specimens taken from the major duodenal papilla of 2 patients with AIP, but in controls, there were only a few (<or=3/HPF) IgG4-positive plasma cells infiltrating the major duodenal papilla.
  • CONCLUSIONS: An abundant infiltration of IgG4-positive plasma cells is specifically detected in the major duodenal papilla of patients with AIP.
  • Although this is a preliminary study, IgG4-immunostaining of biopsy specimens taken from the major duodenal papilla may support the diagnosis of AIP.
  • [MeSH-major] Ampulla of Vater / pathology. Autoimmune Diseases / diagnosis. Pancreatitis / diagnosis

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  • (PMID = 16610052.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Immunoglobulin G
  • [Other-IDs] NLM/ PMC4087680
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92. He KJ, Jiao XY, Yang XW, Hu YZ: [Risk factors of postoperative complications of pancreatoduodenectomy]. Ai Zheng; 2008 Jan;27(1):75-7
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  • BACKGROUND & OBJECTIVE: Pancreatoduodenectomy is the main treatment for pancreatic carcinoma and periampullary carcinoma.
  • This study was to explore risk factors of postoperative complications of pancreatoduodenectomy for pancreatic carcinoma and periampullary carcinoma.
  • METHODS: Clinical data of 94 patients with pancreatic carcinoma or periampullary carcinoma, underwent pancreatoduodenectomy at the second affiliated hospital of Guangzhou Medical Collage and Gansu Provincial Tumor Hospital from Jan.
  • CONCLUSION: Postoperative mortality and morbidity of pancreatoduodenectomy for periampullary carcinoma are closely related to intra-operative bleeding, operating time, serum bilirubin level and duration of jaundice.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / adverse effects. Postoperative Hemorrhage / etiology
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Female. Gastrointestinal Hemorrhage / etiology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Pancreatic Fistula / etiology. Proportional Hazards Models. Retrospective Studies. Risk Factors. Serum Albumin / metabolism. Survival Rate

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  • (PMID = 18184469.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Serum Albumin
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93. Kim S, Lee NK, Lee JW, Kim CW, Lee SH, Kim GH, Kang DH: CT evaluation of the bulging papilla with endoscopic correlation. Radiographics; 2007 Jul-Aug;27(4):1023-38
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  • [Title] CT evaluation of the bulging papilla with endoscopic correlation.
  • A variety of pathologic conditions can cause abnormalities of the ampulla of Vater.
  • A bulging papilla is frequently encountered at computed tomography (CT) and can be seen in healthy individuals as well as in patients with various pathologic conditions such as papillitis, ampullary cancer, and intraductal papillary mucinous tumor.
  • Mural thickening and certain attenuation patterns seen at contrast material-enhanced CT can help differentiate pathologic papilla from normal papilla.
  • Increased targetlike enhancement of the papilla is likely to represent a benign condition such as papillitis, whereas an enhancing polypoid mass or focal asymmetric or irregular thickening with prolonged enhancement in the ampulla of Vater indicates a malignant condition such as ampullary or periampullary carcinoma.
  • Although CT often does not clarify the exact cause of bulging, adequate duodenal distention may allow detection of an abnormal papilla, thereby providing additional information about other abnormalities in the pancreaticobiliary system.
  • MR cholangiography may be equivalent to CT for identifying a bulging papilla and superior for distinguishing the underlying cause.
  • However, endoscopy with or without biopsy is the best method for making a definitive diagnosis in patients with a bulging papilla.
  • Familiarity with the normal imaging anatomy of the periampullary region and with the imaging features of the various pathologic causes of a bulging papilla may be useful in making the diagnosis.
  • [MeSH-major] Bile Duct Diseases / diagnosis. Bile Ducts / pathology. Cholangiography / methods. Endoscopy / methods. Magnetic Resonance Imaging / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male. Middle Aged. Practice Guidelines as Topic. Practice Patterns, Physicians'. Statistics as Topic

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  • [Copyright] RSNA, 2007
  • (PMID = 17620465.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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94. Milsmann C, Füzesi L, Werner C, Becker H, Horstmann O: [Significance of occult lymphatic tumor spread in pancreatic cancer]. Chirurg; 2005 Nov;76(11):1064-72
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  • [Title] [Significance of occult lymphatic tumor spread in pancreatic cancer].
  • PURPOSE: The aim of this study was to determine the frequency and effect on prognosis of occult tumor cells in regional lymph nodes judged to be tumor-free in conventional histopathology of pancreatic cancer patients.
  • PATIENTS AND METHODS: Among 115 patients who underwent pancreatic resection for pancreatic (n=84) or distal common bile duct malignancy (n=12) or carcinoma of the papilla (n=19), 48 (42%) were staged pN0.
  • However, those cells were encountered more frequently in common bile duct carcinomas (100%) than in pancreatic (36%) or papilla (20%) carcinomas (P=0.009).
  • CONCLUSION: Occult tumor cells are frequent in apparently tumor-free lymph nodes of pancreatic cancer patients and often overlooked in conventional histopathology.
  • Occult tumor cells in lymph nodes of pancreatic cancer patients could be used to stratify adjuvant therapy.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma, Ductal / surgery. Common Bile Duct Neoplasms / surgery. Lymph Node Excision. Lymphatic Metastasis / pathology. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Analysis

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  • (PMID = 15971035.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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95. Furuse J, Okusaka T, Funakoshi A, Yamao K, Nagase M, Ishii H, Nakachi K, Ueno H, Ikeda M, Morizane C, Horikawa Y, Mizuno N: Early phase II study of uracil-tegafur plus doxorubicin in patients with unresectable advanced biliary tract cancer. Jpn J Clin Oncol; 2006 Sep;36(9):552-6
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  • [Title] Early phase II study of uracil-tegafur plus doxorubicin in patients with unresectable advanced biliary tract cancer.
  • BACKGROUND: Standard chemotherapy for advanced biliary tract cancer has not been established.
  • The purpose of this study was to evaluate the efficacy and toxicity of a combination chemotherapy of uracil-tegafur (UFT) and doxorubicin in patients with unresectable advanced biliary tract cancer.
  • METHODS: Patients with histologically or cytologically confirmed, measurable biliary tract cancer, including intrahepatic or extrahepatic cholangiocarcinoma, gallbladder cancer and ampulla of Vater cancer, which was not amenable to surgery, were eligible for the study.
  • CONCLUSIONS: Combination chemotherapy of UFT and doxorubicin was well tolerated and showed preliminary moderate activity against advanced biliary tract cancer.

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  • (PMID = 16887837.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 80168379AG / Doxorubicin; 1-UFT protocol
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96. Higashi M, Goto M, Saitou M, Shimizu T, Rousseau K, Batra SK, Yonezawa S: Immunohistochemical study of mucin expression in periampullary adenomyoma. J Hepatobiliary Pancreat Sci; 2010 May;17(3):275-83
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  • BACKGROUND/PURPOSE: Benign tumors and tumor-like conditions in the ampullary area are uncommon, and there are extremely rare cases of adenomyoma (AM) and adenomyomatous hyperplasia (AMH).
  • In addition, the differential diagnosis of AM and AMH from carcinoma is often difficult by standard endoscopic biopsy and cytopathological analysis that may show differential findings, resulting in unnecessary surgeries sometimes being performed.
  • The EGCs showed no expression of MUC1 or MUC4, both of which were identified as malignant tumor markers in our previous series of mucin expression studies in pancreatobiliary tumors.
  • CONCLUSIONS: A combined evaluation of IHC findings may be effective in the detection of AM and AMH, and also in distinguishing benign periampullary lesions, such as AM and AMH, from ampulla of Vater adenocarcinoma, thus avoiding excessive surgery.

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  • (PMID = 19784541.001).
  • [ISSN] 1868-6982
  • [Journal-full-title] Journal of hepato-biliary-pancreatic sciences
  • [ISO-abbreviation] J Hepatobiliary Pancreat Sci
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA078590; United States / NCI NIH HHS / CA / CA 78590
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC4 protein, human; 0 / MUC5AC protein, human; 0 / MUC6 protein, human; 0 / Mucin 5AC; 0 / Mucin-4; 0 / Mucin-6; 0 / Mucins
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97. Park SK, Andreotti G, Sakoda LC, Gao YT, Rashid A, Chen J, Chen BE, Rosenberg PS, Shen MC, Wang BS, Han TQ, Zhang BH, Yeager M, Chanock S, Hsing AW: Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China. Carcinogenesis; 2009 Apr;30(4):606-14
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  • Biliary tract cancers, encompassing gallbladder, extrahepatic bile duct and ampulla of Vater cancers, are uncommon but often fatal malignancies.
  • This study included subjects who completed an interview and provided blood, which totaled 411 biliary tract cancer and 893 biliary stone patients and 786 healthy Shanghai residents.
  • The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2.0, 95% confidence interval (CI), 1.3-3.0] and bile duct cancers (OR = 1.8, 95% CI = 1.1-3.1), whereas the CYP1A1 Ex7 + 131 (rs1048943) G allele was associated with ampulla of Vater cancer (OR = 2.9, 95% CI = 1.5-5.4).
  • After taking into account multiple comparisons for SNPs within each gene, CYP1A1 was significantly associated with gallbladder (P = 0.004) and ampulla of Vater cancers (P = 0.01), but borderline with bile duct cancer (P = 0.06).
  • The effect of CYP1A1 IVS1 + 606 on gallbladder cancer was more pronounced among non-obese (body mass index < 23) (OR = 3.3, 95% CI = 1.8-6.1; P interaction = 0.001).
  • Among women taking oral contraceptives, the effect of SHBG Ex8 + 6 (rs6259) on gallbladder cancer (OR = 6.7, 95% CI = 2.2-20.5; P interaction = 0.001) and stones (OR = 2.3, 95% CI = 1.1-4.9; P-interaction = 0.05) was statistically significant.

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  • (PMID = 19168589.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Contraceptives, Oral, Hormonal; 0 / Hormones; 9007-49-2 / DNA; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
  • [Other-IDs] NLM/ PMC2664453
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98. Peng SY, Hong DF, Liu YB, Li JT, Tao F, Tan ZJ: [A pancreas suture-less type II binding pancreaticogastrostomy]. Zhonghua Wai Ke Za Zhi; 2009 Dec 1;47(23):1764-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: From November 2008 to May 2009, 26 patients underwent pancreaticoduodenectomy and mid-segmentectomy of pancreas with type II BPG reconstruction, including 13 cases of pancreatic head cancer, 3 cases of duodenal adenocarcinoma, 2 cases of ampullary carcinoma, 4 cases of cholangiocarcinoma, 1 case of bile duct cell severe atypical hyperplasia, and 1 case of stomach cancer.
  • No mortality or pancreatic leakage occurred.

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  • (PMID = 20193541.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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99. Aloysius MM, Lobo DN, Rowlands BJ, Madhusudan S, Ilyas M, Zaitoun AM: HER-2/Neu overexpression is a rare event in peri-ampullary cancer: assessment using the HercepTest. Histopathology; 2009 Aug;55(2):236-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HER-2/Neu overexpression is a rare event in peri-ampullary cancer: assessment using the HercepTest.
  • [MeSH-major] Adenocarcinoma / metabolism. Ampulla of Vater. Carcinoma, Pancreatic Ductal / metabolism. Pancreatic Neoplasms / metabolism. Receptor, ErbB-2 / analysis

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  • (PMID = 19694833.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Reagent Kits, Diagnostic; EC 2.7.10.1 / Receptor, ErbB-2
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100. Bucher P, Chassot G, Durmishi Y, Ris F, Morel P: Long-term results of surgical treatment of Vater's ampulla neoplasms. Hepatogastroenterology; 2007 Jun;54(76):1239-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results of surgical treatment of Vater's ampulla neoplasms.
  • BACKGROUND/AIMS: Vater's ampulla neoplasms account for 30% of resected bilio-pancreatic confluent tumors.
  • Study aim was to review long-term results of surgical treatment for ampullary neoplasms.
  • METHODOLOGY: A retrospective review from 1993 to 2002 identified 55 patients admitted for Vater's ampulla neoplasm in our institution.
  • RESULTS: Among the ampullary neoplasms, 10 were adenomas (median age 71) and 45 adenocarcinomas (median age 69).
  • The resectability rate of ampullary carcinomas was 84%.
  • CONCLUSIONS: Pancreatoduodenectomy remains the gold standard for Vater's ampulla neoplasms resection due to the low sensitivity of diagnostic biopsies for carcinoma detection.
  • Vater's ampulla neoplasms resection by pancreatoduodenectomy is associated with good long-term results; however survival after curative resection is influenced by lymph node status.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 17629078.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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