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[Title] Laparoscopic pancreaticoduodenectomy to treat cancer of the ampulla of Vater.

Three patients had duodenal papillary cancer, one had cancer of the head of the pancreas, and one had pancreatic mixed cancer (duodenal papillary cancer, hepatobiliary ductal adenocarcinoma).

RESULTS: The pathology diagnosis was well-differentiated duodenum papillary adenocarcinoma in 3 patients, head of pancreas endocrine small cell carcinoma in 1, and duodenum papillary adenoma with malignancy ductal intermediate differentiation adenocarcinoma in 1.

After surgery, 1 patient had a small amount of pancreatic leakage, another developed stress ulcer bleeding; both patients became normal after appropriate treatment.

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(PMID = 16709370.001).

[ISSN] 1086-8089

[Journal-full-title] JSLS : Journal of the Society of Laparoendoscopic Surgeons

[ISO-abbreviation] JSLS

[Language] ENG

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC3015677

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Usefulness of follow-up after pancreatoduodenectomy for carcinoma of the ampulla of Vater.

BACKGROUND: The prognosis for carcinoma of the ampulla of Vater (CAV) is better than for pancreatic cancer.

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(PMID = 18333130.001).

[ISSN] 1365-182X

[Journal-full-title] HPB : the official journal of the International Hepato Pancreato Biliary Association

[ISO-abbreviation] HPB (Oxford)

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2020781

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Determinants of long-term survival in 38 patients with carcinoma of ampulla of Vater treated by local resection].

OBJECTIVE: To investigate determinants of long-term survival for carcinoma of ampulla of Vater treated by local resection.

On deciding for resection, the common bile duct was probe explored which guided the circumferential ring resection 1 cm, away from the tumor, including all layers of duodenum, ampula and partial bile and terminal pancreatic ducts and the posterial wall of duodenum was completed in steps.

Meticulous care was taken not to suture the pancreatic duct and endotheliation was ensured at the mouth of common bile duct and duodenum.

Preferably it is indicated only in high risk patients with a pT1 and well differentiated ampullary cancer smaller than 1 cm in diameter.

[MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery

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(PMID = 16438877.001).

[ISSN] 0253-3766

[Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]

[ISO-abbreviation] Zhonghua Zhong Liu Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Clinical significance of solitary lymph node metastasis in carcinoma of the ampulla of Vater].

OBJECTIVE: To investigate the rule of distribution of solitary lymph node metastasis and its relation with clinico-pathologic factors in carcinoma of ampulla of Vater.

METHODS: The data of 26 patients who were discovered to have solitary lymph node metastasis, from 152 patients with carcinoma of the ampulla of Vater who had received pancreatoduodenectomy were retrospectively reviewed.

RESULTS: Of these 152 patients with carcinoma of ampulla of Vater, 47(30.

000) and pancreatic infiltration (P =0. 009).

Sentinel lymph node assessment may be helpful to determine the extent of lymph node dissection for carcinoma of the ampulla of Vater.

[MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology

[MeSH-minor] Adult. Aged. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy. Retrospective Studies. Sentinel Lymph Node Biopsy

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(PMID = 17274378.001).

[ISSN] 0253-3766

[Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]

[ISO-abbreviation] Zhonghua Zhong Liu Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Tumors of the ampulla of Vater--local or radical resection?].

[Transliterated title] Tumorile benigne ale ampulei lui Vater--rezecţie locală sau radicală?

Duodenal ampulla is a complex anatomical and histological site and a tumor may arise from one of three types of epithelium: duodenal mucosa, pancreatic duct and distal common bile duct.

Benign adenomas appear to be a frequent precursor of carcinoma of the ampulla of Vater, therefore, a local resection can lead to an under treated early cancer which would have benefited from a radical excision, with a much better long term result.

[MeSH-major] Adenoma / surgery. Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery

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(PMID = 17571553.001).

[ISSN] 0048-7848

[Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i

[ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi

[Language] rum

[Publication-type] English Abstract; Journal Article

[Publication-country] Romania

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection.

INTRODUCTION: The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms.

Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected.

The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected ampullary carcinoma.

METHODS: Clinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002.

Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).

CONCLUSIONS: Carcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

[MeSH-minor] Adolescent. Adult. Aged. Female. Hospital Mortality. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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(PMID = 17171495.001).

[ISSN] 0364-2313

[Journal-full-title] World journal of surgery

[ISO-abbreviation] World J Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Number of lymph node metastases: a significant prognostic factor for patients with radical resection of carcinoma of the ampulla of Vater].

OBJECTIVE: To identify prognostic factors predicting survival after radical resection of ampullary carcinoma.

METHODS: Clinical data of sixty- five patients with cancer of the ampulla of Vater underwent pancreaticoduodenectomy and regional lymphadenectomy were analyzed retrospectively.

CONCLUSION: The number of positive regional lymph nodes is an independent prognostic factor in patients with ampullary carcinoma after resection.

[MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / diagnosis. Lymph Nodes / pathology

[MeSH-minor] Adult. Aged. Carcinoma / pathology. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Prognosis. Retrospective Studies

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(PMID = 17659460.001).

[ISSN] 1671-0274

[Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

[ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Signet-ring cell carcinoma of the ampulla of Vater: report of a case.

Signet-ring cell carcinoma (SRCC) of the ampulla of Vater is uncommon, and only 13 cases have been previously described.

We herein report a rare case of a 43-year-old woman with SRCC in the ampulla of Vater.

Although this histologic type of cancer generally predicts a poor prognosis elsewhere in the gastrointestinal tract, the present patient has survived with no evidence of recurrence for 7.5 years.

She underwent a pancreaticoduodenectomy with an extended lymphadenectomy for ampullary carcinoma.

This neoplasm was classified as AcdbBi, 2.0 x 1.8 cm, ulcerative type, Panc(0), Du(2), T(2)N(0)M(-), Stage II according to the Japanese Classification on Cancer of the Biliary Tract.

Unfortunately, previous reports of ampullary SRCC have been limited to short-term follow-ups with a median period of only 12 months (range, 6-134 months), and long-term survival (more than 5 years) was only documented in two cases without lymph node metastasis (including the present case).

In conclusion, the experience gained in the present and previous cases suggests that long-term survival is possible following a curative resection in selected patients with ampullary SRCC without nodal involvement.

Due to the lack of sufficient evidence, additional reports are warranted to determine whether SRCC also portends a poor prognosis in patients with ampullary cancer.

[MeSH-major] Ampulla of Vater. Carcinoma, Signet Ring Cell / pathology. Common Bile Duct Neoplasms / pathology. Pancreaticoduodenectomy / methods

[MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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(PMID = 18030577.001).

[ISSN] 0941-1291

[Journal-full-title] Surgery today

[ISO-abbreviation] Surg. Today

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.

We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of lung tumors into small cell carcinoma (SCC, 6 cases) and large cell neuroendocrine carcinoma (LCNEC, 8 cases) types.

The immunohistochemical findings were compared with those of 13 cases of primary poorly differentiated ampullary adenocarcinomas (PDACA) lacking neuroendocrine morphology.

Overall, 64% of patients with ampullary HGNEC died of disease (mean follow-up, 14.5 months).

Two HGNECs were combined with a conventional adenocarcinoma and another with a squamous cell carcinoma component.

In conclusion, HGNECs of the ampulla are rare (2%-3% of ampullary tumors in our material).

The clinical course parallels that of their pulmonary counterparts and appears to be worse than that of locally advanced ampullary adenocarcinomas.

Loss of Rb expression, a characteristic finding in pulmonary SCCs, is present in almost half of ampullary HGNECs.

Thus, there are differences in the molecular phenotypes of these two types of ampullary carcinoma, supporting the distinction of poorly differentiated carcinomas with a neuroendocrine phenotype from those without.

[MeSH-major] Ampulla of Vater / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology

[MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Survival Rate

NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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(PMID = 15832081.001).

[ISSN] 0147-5185

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] KRAS mutations and relation to prognosis in patients operated for localized pancreatic cancer and other periampullary cancers.

: e15618 Background: Prognostic biomarkers in patients with pancreatic cancer might direct patients to optimal treatment.

We studied the prognostic value of KRAS mutations in patients operated for pancreatic and other periampullary cancers.

For the present pilot study cancer tissue blocks were collected from 58 patients (31 men, 27 women, median age 64, range 33-81 years, ASA 1-3).

All had localized pancreatic (n=26), ampullary (n=26) or duodenal cancer (n=6) and were operated during the period June 2001 to May 2008.

RESULTS: KRAS mutations were found in 32 (55%) of the patients; 16 (62%) patients with pancreatic cancer, 13 (50%) with ampullary cancer and in 3 (50%) with duodenal cancer.

KRAS status was neither associated with type of cancer (p=0.68), TNM stage (T stage p=0.64, N stage p=0.31).

CONCLUSIONS: KRAS mutations are frequent in patients with localized pancreatic, ampullary and duodenal cancers.

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(PMID = 27962729.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Effect of S-1 in a patient with post-operative recurrence of carcinoma of the ampulla of Vater].

We report a case of recurrent carcinoma of the ampulla of Vater with multiple lung and abdominal lymph node metastases that well responded to S-1, an oral fluoropyrimidine.

A 56-years-old woman underwent a pylorus-preserving pancreaticoduodenectomy for carcinoma of the ampulla of Vater in October 2003.

S-1 might be an effective and safe agent for carcinoma of the ampulla of Vater.

[MeSH-major] Ampulla of Vater. Antimetabolites, Antineoplastic / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / surgery. Oxonic Acid / therapeutic use. Tegafur / therapeutic use

[MeSH-minor] Drug Combinations. Female. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local. Pancreaticoduodenectomy

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(PMID = 18079635.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Invasive micropapillary carcinoma of the ampulla of Vater with extensive lymph node metastasis: Report of a case.

Invasive micropapillary carcinoma is characterized by extensive lymph node metastasis and a poor prognosis.

This histological variant was first described in breast cancer, with a few subsequent reports of it in the ampullo-pancreato-biliary region.

We report a case of invasive micropapillary carcinoma of the papilla of Vater.

Detailed investigations revealed a tumor in the periampullary region, and pancreatoduodenectomy was performed for cancer of the ampulla of Vater.

Microscopic examination of the resected specimen revealed a tumor composed mainly of carcinoma cells arranged in micropapillary structures, with extensive regional lymph node metastasis.

[MeSH-major] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery

[MeSH-minor] Fatal Outcome. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness

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(PMID = 21110170.001).

[ISSN] 1436-2813

[Journal-full-title] Surgery today

[ISO-abbreviation] Surg. Today

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection.

This retrospective study investigated the prognostic significance of MK-1 expression in human carcinoma of the ampulla of Vater (CAV).

[MeSH-major] Antigens, Neoplasm / biosynthesis. Cell Adhesion Molecules / biosynthesis. Common Bile Duct Neoplasms / pathology

[MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Ampulla of Vater. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Carcinoma, Small Cell / metabolism. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / surgery. Female. Humans. Immunohistochemistry / statistics & numerical data. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Prognosis. Proportional Hazards Models

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(PMID = 16616808.001).

[ISSN] 0304-3835

[Journal-full-title] Cancer letters

[ISO-abbreviation] Cancer Lett.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Ireland

[Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Radical resection in signet ring carcinoma of the ampulla of Vater: report of an 11-year survivor.

Carcinomas of the ampulla of Vater are uncommon tumors but have a better prognosis than typical pancreatic cancers.

Signet ring features associated with poor differentiation traditionally confer a dismal prognosis in other gastrointestinal malignancies, particularly gastric cancer.

Signet cell ring morphology has only been described in a few ampullary carcinomas with all cases reporting short follow-up.

We describe a 58-year-old woman who presented with painless jaundice and a prominent ampulla of Vater by endoscopy.

She underwent pancreaticoduodenectomy and was found to have a 1.0 x 0.8 cm poorly differentiated carcinoma with prominent signet ring cell features arising from the ampulla of Vater and invading into the periampullary duodenum but sparing the pancreatic parenchyma.

[MeSH-major] Ampulla of Vater. Carcinoma, Signet Ring Cell / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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(PMID = 16536256.001).

[ISSN] 0003-1348

[Journal-full-title] The American surgeon

[ISO-abbreviation] Am Surg

[Language] eng

[Publication-type] Case Reports; Journal Article; Review

[Publication-country] United States

[Number-of-references] 17

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Diagnosis and management of adenocarcinoma of the ampulla of Vater during pregnancy.

BACKGROUND: Cancer of the biliary tract has a poor prognosis and its association with pregnancy is uncommon.

Early diagnosis allowing curative surgical resection offers the only hope of long-term survival.

Histology demonstrated carcinoma of the ampulla of Vater.

CONCLUSION: Pregnant patients with digestive cancer require careful management.

[MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis

Genetic Alliance. consumer health - Pregnancy.

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(PMID = 15808389.001).

[ISSN] 0301-2115

[Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology

[ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Ireland

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Factors influencing recurrence after curative resection for ampulla of Vater carcinoma.

BACKGROUND: Carcinoma of the ampulla of Vater has a relatively higher resection rate, lower recurrence rate, and more favorable prognosis than other malignant tumors of the periampullary region.

Because of the relative low incidence of carcinoma of the ampulla of Vater, there have been few reports on the patterns and risk factors of recurrence after curative resection.

The aim of this study was to evaluate the patterns and risk factors of recurrence after curative resection of ampulla of Vater carcinoma.

MATERIALS AND METHODS: Between January 1992 and December 2002, 102 patients received radical resection for ampulla of Vater carcinoma at Yonsei University Medical Center.

Lymph node metastasis was identified as an independent factor of tumor recurrence after curative resection for ampulla of Vater carcinoma.

[MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Pancreatic Neoplasms / surgery

[MeSH-minor] Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Prognosis. Survival Rate. Treatment Outcome

MedlinePlus Health Information. consumer health - Intestinal Cancer.

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[Copyright] (c) 2006 Wiley-Liss, Inc.

(PMID = 17326125.001).

[ISSN] 0022-4790

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Determinants of long-term survival after pancreaticoduodenectomy for ampulla of Vater carcinoma].

OBJECTIVE: To investigate the determinants of long-term survival for ampulla of Vater carcinoma treated by pancreaticoduodenectomy.

METHODS: A total of 77 patients with ampulla of Vater carcinoma undergoing pancreaticoduodenectomy were reviewed.

Univariate analysis showed that perioperative serum carcinoembryonic antigen (CEA) level (P = 0.012), tumor invasion depth (P = 0.000), UICC stage (P = 0.000) and tumor size (P = 0.001) were significant prognostic factors of ampulla of Vater carcinoma; in multivariate analysis, only the tumor size (P = 0.000) was an independent prognostic factor of ampulla of Vater carcinoma.

[MeSH-major] Ampulla of Vater / surgery. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / mortality

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(PMID = 20223115.001).

[ISSN] 0376-2491

[Journal-full-title] Zhonghua yi xue za zhi

[ISO-abbreviation] Zhonghua Yi Xue Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Acral metastasis in a patient with ampullary carcinoma.

Although skin metastasis from a malignant tumor of an internal organ usually occurs at an advanced disease stage, there has been no prior report of a cutaneous acral metastasis from ampullary carcinoma to date.

We report a 71-year old male patient with cutaneous metastasis from an ampullary adenocarcinoma.

The patient had a history of pylorus preserving pancreaticoduodenectomy for carcinoma of the ampulla of Vater two years prior to presentation.

This case illustrates that cutaneous metastasis from ampullary carcinoma has a poor prognosis.

[MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Skin Neoplasms / secondary

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[Cites] Cancer. 1966 Feb;19(2):162-8 [5948332.001]

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(PMID = 17427649.001).

[ISSN] 1226-3303

[Journal-full-title] The Korean journal of internal medicine

[ISO-abbreviation] Korean J. Intern. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Korea (South)

[Other-IDs] NLM/ PMC2687605

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Ampullary cancer and preoperative jaundice: possible indication of the minimal surgery.

BACKGROUND/AIMS: Obstructive jaundice is common symptom of carcinoma of the ampulla of Vater.

Preoperative jaundice, serum carbohydrate antigen 19-9 level, pancreatic invasion, lymphatic invasion, venous invasion, perineural invasion, duodenal invasion, margin status, lymph node metastasis, and T stage were shown to be significant prognostic factors.

CONCLUSIONS: Preoperative jaundice may reflect advanced-stage in case of ampullary cancer.

[MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / surgery. Jaundice, Obstructive / surgery

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(PMID = 19760968.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Signet ring cell carcinoma of the ampulla of vater. A case report.

CONTEXT: Signet ring cell carcinoma of the ampulla of Vater is extremely rare and only 12 cases have previously been described in the English language literature.

We report a case of advanced signet ring cell carcinoma of the ampulla of Vater, with invasion of the duodenum and pancreas.

Abdominal computed tomography showed dilatation of the common bile duct and the pancreatic duct.

Duodenoscopy indicated an irregularly shaped erosion on the ampulla of Vater.

The diagnosis was carcinoma of the ampulla of Vater, and a pancreaticoduodenectomy was performed.

The histopathological findings detected signet ring cell carcinoma.

[MeSH-major] Ampulla of Vater. Carcinoma, Signet Ring Cell / diagnosis. Common Bile Duct Neoplasms / diagnosis

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(PMID = 19890196.001).

[ISSN] 1590-8577

[Journal-full-title] JOP : Journal of the pancreas

[ISO-abbreviation] JOP

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients.

PURPOSE: To identify potential prognostic molecular factors in ampullary adenocarcinoma that could be of significant importance.

To this end, we examined the possible prognostic significance of cyclooxygenase-2 (Cox-2) and Survivin expression and the apoptotic index in a cohort of uniformly treated patients with ampullary cancer treated with radical surgical excision.

EXPERIMENTAL DESIGN: The entry criteria were that the patients have a pathologic diagnosis of ampullary cancer which had been resected.

RESULTS: Thirty-nine tumor specimens from resected ampullary adenocarcinoma patients were included.

CONCLUSIONS: The results of the present article provide, for the first time, evidence that Cox-2 expression, but not Survivin expression, may represent a significant prognostic factor after surgical resection in patients affected by cancer of the ampulla of Vater.

Further studies are required to determine whether Cox-2 inhibitors may be useful for the therapy or prevention of ampullary carcinoma.

[MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / genetics. Common Bile Duct Neoplasms / pathology. Gene Expression Profiling. Prostaglandin-Endoperoxide Synthases / biosynthesis. Prostaglandin-Endoperoxide Synthases / genetics

[MeSH-minor] Adult. Aged. Apoptosis. Cyclooxygenase 2. Female. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Male. Membrane Proteins. Microtubule-Associated Proteins / biosynthesis. Microtubule-Associated Proteins / genetics. Middle Aged. Neoplasm Proteins. Predictive Value of Tests. Prognosis

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(PMID = 15897577.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Publication-type] Clinical Trial; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Membrane Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program.

BACKGROUND: Cancers of the ampulla are unusual and morphologically heterogeneous.

Based on pathologic and epidemiologic characteristics of cancer of the ampulla available in SEER, important clinicopathological correlations can be made.

METHODS: All patients with cancer of the ampulla were identified between 1973 and 2005.

RESULTS: There were 5,625 cases of ampullary cancer.

Ampullary cancer has been increasing since 1973.

[MeSH-major] Ampulla of Vater / pathology. Carcinoma / mortality. Common Bile Duct Neoplasms / mortality

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(PMID = 19697352.001).

[ISSN] 1096-9098

[Journal-full-title] Journal of surgical oncology

[ISO-abbreviation] J Surg Oncol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A collision tumor composed of cancers of the bile duct and ampulla of Vater--immunohistochemical analysis of a rare entity of double cancer.

Collision cancer of the bile duct and the papilla of Vater is an extremely rare entity.

This is the first report of a case of bile duct collision cancer.

Computed tomography showed isodensity masses in the middle bile duct and the papilla of Vater.

Gastroduodenal endoscopy showed a tumor with ulceration at the papilla of Vater.

The patient was diagnosed with cancers of the middle bile duct and the papilla of Vater, and a pylorus-preserving pancreatoduodenectomy was performed.

On pathological examination, the tumor in the middle bile duct showed a well differentiated carcinoma that had spread to the proximal bile duct, whereas the tumor in the papilla of Vater showed a papillo-tubular carcinoma with a marked production of mucin, suggesting an intestinal type of ampullary cancer.

As a result, it was concluded that this was a case of collision cancer of the middle bile duct and the papilla of Vater.

[MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Papillary / pathology. Ampulla of Vater / pathology. Biomarkers, Tumor / analysis. Common Bile Duct Neoplasms / pathology. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Neoplasms, Multiple Primary / pathology

[MeSH-minor] Aged. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct / pathology. Diagnosis, Differential. Duodenum / pathology. Humans. Male. Neoplasm Invasiveness. Neoplasm Staging. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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(PMID = 18705284.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Therapeutic approach to tumors of the ampulla of Vater.

BACKGROUND/AIM: Indications for local resection for tumors of the ampulla of Vater have not been established.

The present study evaluated suitable treatments for tumors of the papilla of Vater.

PATIENTS AND METHODS: Clinicopathological factors were reviewed for 53 patients with tumors of the ampulla of Vater treated between February 1993 and August 2003.

Lymph node metastasis was identified in 20 patients who received radical resection, including 1 patient with pT1 cancer.

CONCLUSION: Given the presence of some positive surgical margins, local resection is indicated as a therapeutic approach to tumors of the papilla of Vater only for benign tumors or some malignant tumors that cannot undergo pancreaticoduodenectomy (PD).

[MeSH-major] Adenoma / surgery. Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Digestive System Surgical Procedures / methods

[MeSH-minor] Adult. Aged. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Diagnosis, Differential. Endosonography. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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(PMID = 16860623.001).

[ISSN] 0002-9610

[Journal-full-title] American journal of surgery

[ISO-abbreviation] Am. J. Surg.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Can endoscopic resection be applied for early stage ampulla of Vater cancer?

BACKGROUND: Although endoscopic resection can provide a wide tumor resection with a negative resection margin, it is not yet recommended as a curative therapy for ampulla of Vater cancer.

METHODS: To investigate the microinvasion rate and the diagnostic accuracy of endoscopic biopsy to properly judge the safety of endoscopic resection for ampulla of Vater cancer.

PATIENTS: One hundred fifty-nine patients who were finally diagnosed with ampulla of Vater cancer after curative surgical resection.

For the 36 early stage (Tis or T1) cancers, we surveyed the presence of microlymphovascular invasion, gross appearance (intra-ampullary type, periampullary type, or mixed type), and pathologic subtype (intestinal type or pancreaticobiliary type).

MAIN OUTCOME MEASUREMENTS: Presence of microinvasion in early staged ampulla of Vater cancer.

CONCLUSIONS: Although endoscopic resection improves the low predictability of endoscopic biopsy, surgical resection should be performed for the T1 stage ampulla of Vater cancer because of the high lymphovascular invasion rate.

[MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Sphincter of Oddi. Sphincterotomy, Endoscopic

[MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis

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[CommentIn] Gastrointest Endosc. 2006 May;63(6):789-91 [16650539.001]

(PMID = 16650538.001).

[ISSN] 0016-5107

[Journal-full-title] Gastrointestinal endoscopy

[ISO-abbreviation] Gastrointest. Endosc.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma.

BACKGROUND: Nodal metastasis is considered a major prognostic factor in patients with ampulla of Vater carcinoma (AVC).

[MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Lymph Nodes / pathology

[MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Cohort Studies. Duodenal Neoplasms / pathology. Duodenal Neoplasms / secondary. Duodenal Neoplasms / surgery. Female. Follow-Up Studies. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Prognosis. Prospective Studies. Survival Rate

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(PMID = 18712568.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Gemcitabine-based versus fluoropyrimidine-based chemotherapy with or without platinum in unresectable biliary tract cancer: a retrospective study.

Histologically confirmed cases of intrahepatic cholangiocarcinoma, gallbladder cancer, extrahepatic bile duct cancer, and ampulla of Vater carcinoma were enrolled.

Intrahepatic cholangiocarcinoma, gallbladder cancer, extrahepatic bile duct cancer, and ampulla of Vater carcinoma were 92, 72, 58, and 21 cases, respectively.

Genetic Alliance. consumer health - Biliary Tract Cancer.

Hazardous Substances Data Bank. CAPECITABINE .

Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .

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(PMID = 19091129.001).

[ISSN] 1471-2407

[Journal-full-title] BMC cancer

[ISO-abbreviation] BMC Cancer

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Drug Combinations; 0 / Organoplatinum Compounds; 0 / Pyrimidinones; 04ZR38536J / oxaliplatin; 0W860991D6 / Deoxycytidine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 5VT6420TIG / Oxonic Acid; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; 1-UFT protocol

[Other-IDs] NLM/ PMC2615782

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Signet ring cell carcinoma of ampulla of Vater in a young adult.

Signet ring cell carcinoma of the ampulla of Vater is extremely rare.

[MeSH-major] Ampulla of Vater / pathology. Carcinoma, Signet Ring Cell / pathology. Common Bile Duct Neoplasms / pathology

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(PMID = 16361773.001).

[ISSN] 0254-8860

[Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

[ISO-abbreviation] Indian J Gastroenterol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Spontaneous choledochoduodenal fistula after metallic biliary stent placement in a patient with ampulla of vater carcinoma.

Here, we report a case in which a spontaneous choledochoduodenal fistula occurred after biliary metallic stent placement in a patient with an Ampulla of Vater carcinoma but was successfully managed by supportive treatments, including nasobiliary drainage.

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(PMID = 20431778.001).

[ISSN] 2005-1212

[Journal-full-title] Gut and liver

[ISO-abbreviation] Gut Liver

[Language] eng

[Publication-type] Journal Article

[Publication-country] Korea (South)

[Other-IDs] NLM/ PMC2852731

[Keywords] NOTNLM ; Ampulla of Vater / Choledochoduodenal fistula / Stents

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma.

The influences of histologic type and perineural invasion on recurrence and survival in ampullar of Vater carcinoma still need to be assessed.

METHODOLOGY: We reviewed and analyzed the clinicopathologic data, surgical outcomes, recurrence and survival of 49 patients who received curative pancreatoduodenectomy for ampulla of Vater carcinoma at Hanyang University Hospital between July 1994 and June 2008.

[MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Peripheral Nerves / pathology

[MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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(PMID = 20698243.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.

The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of the papilla of Vater and their precursor lesions are not well established.

We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of MMR proteins and specific histopathologic features.

Patients with MSI-H carcinoma had a significantly longer overall survival (P=0.0082) than those with MSI-L or MSS tumors.

The MMR deficient molecular pathway of carcinogenesis is associated with a histopathologic phenotype in ampullary cancer, similar to the one that has been well described in colon cancer.

[MeSH-major] Adenoma / pathology. Ampulla of Vater / pathology. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair. Gene Expression Regulation, Neoplastic. Microsatellite Instability. Precancerous Conditions / pathology

[MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Differentiation. DNA Methylation. DNA-Binding Proteins / genetics. Europe. Female. Gene Deletion. Genotype. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. MutS Homolog 2 Protein / genetics. Neoplasm Invasiveness. Neoplasm Staging. Nuclear Proteins / genetics. Phenotype. Polymerase Chain Reaction. Promoter Regions, Genetic. Proportional Hazards Models. Risk Assessment. Treatment Outcome

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(PMID = 19252434.001).

[ISSN] 1532-0979

[Journal-full-title] The American journal of surgical pathology

[ISO-abbreviation] Am. J. Surg. Pathol.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] United States

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A case of early carcinoma of the papilla of Vater confined to the mucosa and continuative epithelium of glands in Oddi's sphincter (m-God) treated by endoscopic papillectomy.

We herein report a case of early stage ampullary cancer, treated by endoscopic papillectomy, in which tumor extension was confined to the mucosa and adjacent epithelium of the glands in Oddi's sphincter.

A 77-year-old man underwent screening esophagogastroduodenoscopy, which revealed a mass in the papilla of Vater, which was well-differentiated adenocarcinoma as proven by biopsy.

[MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Duodenoscopy

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(PMID = 21088347.001).

[ISSN] 1349-7235

[Journal-full-title] Internal medicine (Tokyo, Japan)

[ISO-abbreviation] Intern. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic factors and clinicopathological characteristics of carcinoma of ampulla Vateri.

The aim of this study was to describe the clinicopathological characteristics and prognostic factors of carcinoma of ampulla Vateri.

Carcinoma of ampulla Vateri is a rare gastrointestinal tumor.

[MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / pathology

[MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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(PMID = 19731856.001).

[ISSN] 0020-8868

[Journal-full-title] International surgery

[ISO-abbreviation] Int Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] Italy

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Histochemical expression of sialoglycoconjugates in carcinoma of the papilla of Vater.

BACKGROUND/AIMS: Cell surface glycosylation changes during oncogenesis and is thought to correlate with the malignant potential of cancers.

To investigate the role of sialylation in carcinoma of the papilla of Vater, histochemical analyses were performed using sialic acid-binding lectins, Maackia amurensis leukoagglutinin and Sambucus nigra agglutinin.

METHODOLOGY: Thirty-six papillary carcinoma tissues and 8 normal papillary tissues were subjected to lectin-histochemical staining.

Of 36 papillary carcinoma tissues, 20 showed Maackia amurensis leukoagglutinin-positive staining in cancer cells, whereas all 36 were Sambucus nigra agglutinin-positive in cancer cells.

Statistical analysis indicated that positive staining in cancer cells was frequent in cases of lymph node metastasis (p=0.001) and in cases classified > or = T2 by TNM classification (p=0.036).

CONCLUSIONS: Aberrant expression of sialoglycoconjugates recognized by Maackia amurensis leukoagglutinin might participate in lymph node metastasis and in an advanced stage of invasion in carcinoma of the papilla of Vater.

[MeSH-major] Ampulla of Vater / metabolism. Carcinoma / metabolism. Common Bile Duct Neoplasms / metabolism. Sialoglycoproteins / metabolism

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(PMID = 15782996.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Greece

[Chemical-registry-number] 0 / Phytohemagglutinins; 0 / Plant Lectins; 0 / Sambucus nigra lectins; 0 / Sialoglycoproteins; 0 / leukoagglutinins, plants; EC 3.2.2.22 / Ribosome Inactivating Proteins

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Carcinoma of the ampulla of vater arising from the peribiliary gland.

The present paper reported a case of a carcinoma that probably developed from the peribiliary gland within the ampulla of Vater based on the histopathological findings of the resected specimens.

A 49-year-old female became aware of epigastralgia and was diagnosis of stenosis of duodenal 2nd portion.

There were no malignant findings on gastrointestinal endoscopy and computed thomography.

Endoscopic retrograde cholangiopancreatography revealed no tumor in the main pancreatic duct or the common bile duct or ampulla of Vater.

Pylorus preserving panctreaticoduodenectomy was performed with a diagnosis of duodenal stenosis of unknown cause.

The histopathological findings revealed that a moderately to poorly differentiated adenocarcinoma originating near the peribiliary gland in the ampulla of Vater was extensively distributed in the submucosal layer of the duodenum.

Based on these findings, a diagnosis of a carcinoma of the ampulla of Vater arising from the peribiliary gland was most likely suspected.

Judging from the generally known development and extension of carcinoma of the ampulla of Vater, the current case appeared to be a very rare one.

[MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology

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(PMID = 19950826.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection.

A 72-year-old man, with known prostate cancer, was admitted to our endoscopic unit for further evaluation of an obstruction at major papilla level.

Endoscopic cholangiopancreatography revealed a depressed-type carcinoma at the ampulla of Vater and dilation of both the common bile and pancreatic ducts without intraductal filling defects.

Intraductal ultrasonography showed a hypoechoic mass limited to the ampulla of Vater.

Histologic examination of the resected specimen showed a completely excised well-differentiated adenocarcinoma limited to the ampulla of Vater.

Both accurate preoperative staging and proper histologic evaluation of the resected specimen seem to justify endoscopic treatment of early ampullary cancer by an experienced endoscopist.

[MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods

[MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Endosonography. Humans. Male. Neoplasm Staging. Treatment Outcome

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(PMID = 18097317.001).

[ISSN] 1530-4515

[Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques

[ISO-abbreviation] Surg Laparosc Endosc Percutan Tech

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Multiple imaging techniques in the diagnosis of ampullary carcinoma.

BACKGROUND: Ampullary carcinoma is a neoplasia with a good prognosis compared to pancreatic cancer.

This study aimed to evaluate the efficacy of abdominal ultrasonography (US), enhanced computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) in detecting ampullary carcinoma.

METHODS: Forty-one patients with ampullary carcinoma who had been confirmed pathologically among the inpatients at the First Affiliated Hospital of Zhejiang University School of Medicine from February 2003 to March 2007 were analyzed retrospectively.

The accuracy of US, CT, MRCP and ERCP were compared in the diagnosis of ampullary carcinoma.

RESULTS: The accurate rate for detection of ampullary carcinoma with US was 26.83%.

The accuracy of CT and ERCP in detection of ampullary tumors was 84.62% and 100%, respectively, which were significantly higher than that of US (P<0.05).

The accuracy of MRCP in detection of ampullary tumors was similar to that of US in spite of visualization of obstruction and dilatation of the pancreaticobiliary duct with MRCP.

CONCLUSIONS: Because of the obscure and late onset of symptoms, ampullary carcinoma is difficult to diagnose early.

[MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Papillary / diagnosis. Bile Duct Neoplasms / diagnosis. Diagnostic Techniques, Digestive System / standards

[MeSH-minor] Adult. Aged. Ampulla of Vater. Cholangiopancreatography, Endoscopic Retrograde / standards. Diagnosis, Differential. Early Diagnosis. Humans. Magnetic Resonance Imaging / standards. Middle Aged. Prognosis. Reproducibility of Results. Retrospective Studies. Tomography, X-Ray Computed / standards. Ultrasonography / standards

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(PMID = 19073413.001).

[ISSN] 1499-3872

[Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT

[ISO-abbreviation] HBPD INT

[Language] eng

[Publication-type] Comparative Study; Journal Article; Validation Studies

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Carcinoids and high-grade neuroendocrine carcinomas of the ampulla of vater: a comparative analysis of 139 cases from the surveillance, epidemiology, and end results program-a population based study.

CONTEXT: Neuroendocrine tumors of the ampulla of Vater constitute a heterogeneous group of neoplasms clinically and morphologically.

OBJECTIVE: To analyze the demographics and the 5- and 10-year relative survival rates of 139 patients with carcinoid tumors and high-grade neuroendocrine carcinomas of the ampulla.

DESIGN: Using data from National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program from 1973 to 2006, we analyzed the demographics, morphology, and survival of patients with carcinoids and neuroendocrine carcinomas of the ampulla.

RESULTS: SEER recorded 6081 cases of malignant neoplasms of the ampulla, of which 82 were carcinoid tumors and 57 were high-grade neuroendocrine carcinomas.

CONCLUSIONS: Carcinoids of the ampulla of Vater are relatively rare.

Carcinoids and high-grade neuroendocrine carcinomas of the ampulla are biologically and clinically similar to these tumors arising in other sites.

[MeSH-major] Ampulla of Vater / pathology. Carcinoid Tumor / epidemiology. Carcinoma, Neuroendocrine / epidemiology. Common Bile Duct Neoplasms / epidemiology

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(PMID = 21043824.001).

[ISSN] 1543-2165

[Journal-full-title] Archives of pathology & laboratory medicine

[ISO-abbreviation] Arch. Pathol. Lab. Med.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters.

Epidemiological studies suggest that regular intake of nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with reduced incidence of gastrointestinal cancer.

The aim of our study was to assess COX-2 expression in a series of primary untreated ampullary carcinomas and its possible correlation with clinicopathological parameters.

In the present study, 45 surgical specimens of invasive ampullary carcinomas were histologically classified into pancreaticobiliary, intestinal, and unusual types.

High COX-2 expression was detected in 35 (77.8%) ampullary carcinomas.

The different COX-2 expression among histopathological types supports the concept of histogenetical difference of ampullary carcinomas.

Furthermore, the high rate of COX-2 expression in the intestinal subtype of ampullary carcinoma may represent the rational for a histotype-tailored therapy targeting COX-2.

[MeSH-major] Adenocarcinoma / enzymology. Ampulla of Vater / enzymology. Common Bile Duct Neoplasms / enzymology. Cyclooxygenase 2 / metabolism

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(PMID = 16906389.001).

[ISSN] 0945-6317

[Journal-full-title] Virchows Archiv : an international journal of pathology

[ISO-abbreviation] Virchows Arch.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Recurrence and prognostic factors of ampullary carcinoma after radical resection: comparison with distal extrahepatic cholangiocarcinoma.

BACKGROUND: Ampullary carcinoma is often considered to have a better prognosis than distal extrahepatic cholangiocarcinoma.

METHODS: Clinicopathologic factors and the long-term outcomes of 163 patients with ampullary carcinoma after radical resection were retrospectively evaluated and compared with those of 91 patients with distal extrahepatic cholangiocarcinoma.

RESULTS: Among the 163 ampullary carcinomas, T1 stage, well-differentiated tumors and perineural invasion were 45 (28%), 73 (45%), and 23 (14%), respectively, whereas, only five (6%) were T1 stage, 15 (17%) were well differentiated, and 63 (69%) showed perineural invasion (p < 0.001, for all) in distal extrahepatic cholangiocarcinomas.

More patients with distal extrahepatic cholangiocarcinoma had liver metastasis than ampullary carcinoma (24% vs. 10%, p = 0.004).

Multivariate analysis identified venous invasion and perineural invasion as risk factors for recurrence of ampullary carcinoma after radical resection.

Overall five-year survival of patients with ampullary cancer was higher than that of patients with distal extrahepatic cholangiocarcinoma (68% vs. 54%; p = 0.033).

CONCLUSION: Earlier diagnosis and the less frequent occurrence of pathological factors associated with tumor invasiveness in ampullary carcinoma than in distal extrahepatic cholangiocarcinoma may explain its association with a better prognosis.

[MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Extrahepatic / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Neoplasm Recurrence, Local / diagnosis

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(PMID = 17710498.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Carcinoma of the papilla of Vater: are endoscopic appearance and endoscopic biopsy discordant?

Carcinoma of the papilla of Vater is classified as periampullary cancer representing 5% of all gastrointestinal tract malignancies.

Early and accurate diagnosis is important for those patients with a tumor of the papilla, as the prognosis is more favorable than in other periampullary neoplasms.

Thirty patients with suspicion of carcinoma of the papilla of Vater and with final diagnosis established by pancreatoduodenectomy were included in this retrospective study.

Although preoperative diagnosis of carcinoma of the papilla of Vater is useful for making therapeutic decisions, the diagnostic value of the endoscopic appearance was superior to endoscopic biopsy in this series.

[MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Duodenoscopy

[MeSH-minor] Biopsy / methods. Diagnosis, Differential. Humans. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Severity of Illness Index

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(PMID = 16966033.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Small-cell neuroendocrine carcinoma of the ampulla of Vater.

We report a patient (an 80-year-old woman) with anemia and fecal occult blood, who had an emergency operation for carcinoma of the cecum (well-differentiated adenocarcinoma without local lymph node metastasis).

Postoperative magnetic resonance cholangiopancreatography, cholangiography, and upper gastroduodenal endoscopy showed a tumor of the ampulla of Vater, and pylorus-preserving pancreatoduodenectomy was performed.

Histology of the resected tumor was that of small-cell carcinoma, and immunohistochemistry showed positive staining for neuron-specific enolase, chromogranin A, and synaptophysin, confirming the neuroendocrine nature of the tumor.

As the histology of the tumor was distinct from cecal carcinoma, and no tumors were found in other organs, the tumor was diagnosed as primary small-cell neuroendocrine carcinoma of the ampulla of Vater.

The patient died due to multiple liver metastases of the carcinoma of the ampulla of Vater 7 months after the pancreatoduodenectomy.

[MeSH-major] Ampulla of Vater. Carcinoma, Neuroendocrine / pathology. Carcinoma, Small Cell / pathology. Common Bile Duct Neoplasms / pathology

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(PMID = 17013721.001).

[ISSN] 0944-1166

[Journal-full-title] Journal of hepato-biliary-pancreatic surgery

[ISO-abbreviation] J Hepatobiliary Pancreat Surg

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Carcinoma of the papilla of Vater following treatment of pancreaticobiliary maljunction.

Pancreaticobiliary maljunction (PBM) is frequently associated with biliary cancer due to reflux of pancreatic enzymes into the choledochus, and even after surgery to correct the PBM such patients still have a risk of residual bile duct cancer.

Here, we report the case of a 59-year-old female with carcinoma of the papilla of Vater which developed 2.5 years after choledochoduodenostomy for PBM.

As a result, carcinoma of the papilla of Vater was diagnosed at an early stage, followed by surgical cure.

For early detection of periampullary cancer in patients undergoing surgery for PBM, careful long-term follow-up is needed.

[MeSH-major] Adenocarcinoma / etiology. Ampulla of Vater / pathology. Bile Ducts, Extrahepatic / abnormalities. Common Bile Duct Neoplasms / etiology. Pancreatic Ducts / abnormalities. Postoperative Complications / etiology

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(PMID = 20027689.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Other-IDs] NLM/ PMC2797673

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic significance of vascular endothelial growth factor expression and microvessel density in carcinoma of ampulla of Vater.

BACKGROUND/AIMS: To investigate whether the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) are of prognostic significance in ampullary carcinoma.

METHODOLOGY: Twenty-two resected tumor specimens from patients with ampullary carcinoma were immunohistochemically stained for VEGF and CD34 (surrogate for vessels) by streptavidin-peroxidase method.

CONCLUSIONS: VEGF is positively correlated with MVD in ampullary carcinoma.

VEGF and angiogenesis may play an important role in lymph node metastasis and progression of ampullary carcinoma.

VEGF and MVD appear to be important prognostic predictor in patients with ampullary carcinoma.

[MeSH-major] Ampulla of Vater. Carcinoma / blood supply. Carcinoma / metabolism. Common Bile Duct Neoplasms / blood supply. Common Bile Duct Neoplasms / metabolism. Vascular Endothelial Growth Factor A / biosynthesis

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(PMID = 16506374.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Unusual histological findings after partial pancreaticoduodenectomy including benign multicystic mesothelioma, adenomyoma of the ampulla of Vater, and undifferentiated carcinoma, sarcomatoid variant: a case series.

INTRODUCTION: The standard operation for carcinoma of the pancreatic head is a partial pancreaticoduodenectomy.

Histology showed an adenomyoma of the ampulla.

Pathology showed an undifferentiated carcinoma, sarcomatoid variant.

Adenomyoma of the bile duct or ampullary region is a very unusual, benign, localized lesion characterized by adenomyomatous hyperplasia.

Undifferentiated carcinoma, sarcomatoid variant, is an aggressive tumor and is characterized by spindle cells.

As the lesions were suspicious for carcinoma, partial pancreaticoduodenectomy was justified in all three patients.

The histologic diagnosis after partial pancreaticoduodenectomy may differ from the preoperative and intraoperative findings.

These cases demonstrate that a definitive diagnosis may only be obtained by a pathologic examination of the surgical specimen.

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(PMID = 21143956.001).

[ISSN] 1752-1947

[Journal-full-title] Journal of medical case reports

[ISO-abbreviation] J Med Case Rep

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC3016302

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables.

To data, there have been few clinicopathological studies on COX-2 expression in human ampullary carcinoma and no data have been reported about its relation with tumour angiogenesis.

OBJECTIVE: To investigate by immunohistochemistry the expression of COX-2 and the angiogenesis process in a series of primary untreated ampullary carcinomas.

METHODS: Tissue samples from 40 archival ampullary carcinomas were analysed for COX-2, vascular endothelial growth factor (VEGF), and an endothelial cell marker von Willebrand factor (vWF) by immunohistochemistry, using specific antibodies.

CONCLUSIONS: COX-2 is highly expressed in ampullary carcinomas.

This suggests an involvement of the COX-2 pathway in ampullary tumour associated angiogenesis, providing a rationale for targeting COX-2 in the treatment of ampullary cancer.

[MeSH-major] Ampulla of Vater. Carcinoma / enzymology. Common Bile Duct Neoplasms / enzymology. Cyclooxygenase 2 / analysis. Neovascularization, Pathologic / etiology

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(PMID = 16489179.001).

[ISSN] 0021-9746

[Journal-full-title] Journal of clinical pathology

[ISO-abbreviation] J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers; 0 / Vascular Endothelial Growth Factor A; 0 / von Willebrand Factor; EC 1.14.99.1 / Cyclooxygenase 2

[Other-IDs] NLM/ PMC1860297

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] A rare case of periampullary carcinoma with ectopic ending of Vater's ampulla.

Magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP) showed the ectopic hepatopancreatic ampulla draining into the fourth part of the duodenum adjacent to the duodenojejunal flexure; the irregular morphology of the duodenojejunal flexure likely due to a soft tissue mass.

Laparotomy confirmed the presence of the abnormal ampulla of Vater located at the fourth part of the duodenum and a soft tissue tumor about 6 cm x 5 cm x 5 cm with a peduncle adjoining the ampulla.

Periampullary carcinoma with ectopic ending of the Vater's ampulla into the fourth part of the duodenum is rather rare.

It is worth mentioning that MRCP is useful for demonstrating anomalies and anatomic variants of the biliary tract system and pancreatic duct.

[MeSH-major] Adenoma, Villous / diagnosis. Ampulla of Vater / abnormalities. Duodenal Neoplasms / diagnosis

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[Cites] Ann Gastroenterol Hepatol (Paris). 1996 Nov-Dec;31(6):346-8 [8920078.001]

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[Cites] Folia Morphol (Warsz). 2005 Feb;64(1):51-3 [15832271.001]

(PMID = 19787838.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / Biomarkers, Tumor

[Other-IDs] NLM/ PMC2754523

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Ampullary carcinoma: effect of preoperative biliary drainage on surgical outcome.

AIM: To evaluate the influence of preoperative biliary drainage on morbidity and mortality after surgical resection for ampullary carcinoma.

METHODS: We analyzed retrospectively data for 82 patients who underwent potentially curative surgery for ampullary carcinoma between September 1993 and July 2007 at the Singapore General Hospital, a tertiary referral hospital.

Diagnosis of ampullary carcinoma was confirmed histologically.

The following parameters were analyzed: wound infection, intra-abdominal abscess, intra-abdominal or gastrointestinal bleeding, septicemia, biliary or pancreatic leakage, pancreatitis, gastroparesis, and re-operation rate.

However, the rest of the parameters did not differ significantly between the groups, i.e. sepsis [10 (28.6%) vs 14 (29.8%)], intra-abdominal bleeding [1 (2.9%) vs 5 (10.6%)], intra-abdominal abscess [1 (2.9%) vs 8 (17%)], gastrointestinal bleeding [3 (8.6%) vs 5 (10.6%)], pancreatic leakage [2 (5.7%) vs 3 (6.4%)], biliary leakage [2 (5.7%) vs 3 (6.4%)], pancreatitis [2 (5.7%) vs 2 (4.3%)], gastroparesis [6 (17.1%) vs 10 (21.3%)], need for blood transfusion [10 (28.6%) vs 17 (36.2%)] and re-operation rate [1 (2.9%) vs 5 (10.6%)].

CONCLUSION: Biliary drainage before surgery for ampullary cancer significantly reduced postoperative wound infection.

[MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Drainage. Pancreatic Neoplasms / surgery. Preoperative Care

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[Cites] HPB Surg. 2000;11(5):311-8 [10674746.001]

[Cites] Br J Surg. 1994 Aug;81(8):1195-8 [7741850.001]

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[Cites] J Gastrointest Surg. 2000 May-Jun;4(3):258-67; discussion 267-8 [10769088.001]

(PMID = 19533815.001).

[ISSN] 2219-2840

[Journal-full-title] World journal of gastroenterology

[ISO-abbreviation] World J. Gastroenterol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

[Other-IDs] NLM/ PMC2699011

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater.

Cancer of the papilla of Vater (CPV) has a significantly better outcome compared to pancreatic cancer (PC) after curative resection.

Quantitative real-time reverse transcription-PCR was performed to analyze expression of SPARC mRNA in a series of 31 PC and 8 CPV specimens and corresponding uninvolved pancreatic tissues.

SPARC mRNA expression was detected in all tumor and normal tissues of the pancreas and papilla of Vater.

In pancreatic cancer, 15/31 (48.4%) patients showed overexpression of SPARC (ratio tumor/normal >1) whereas in CPV only 1/8 (12.5%) exhibited SPARC overexpression and this difference was statistically significant (p<0.05, Mann-Whitney test).

[MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / genetics. Gene Expression Regulation, Neoplastic. Osteonectin / genetics. Pancreatic Neoplasms / genetics. RNA, Messenger / genetics

[MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Pancreatic Ductal / genetics. Carcinoma, Pancreatic Ductal / metabolism. Female. Humans. Male. Middle Aged. Pancreas / metabolism. Pancreas / pathology. Survival Rate

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(PMID = 16596217.001).

[ISSN] 1021-335X

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Osteonectin; 0 / RNA, Messenger

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Large-cell neuroendocrine carcinoma of the ampulla of Vater.

Large-cell neuroendocrine carcinoma is a high-grade neuroendocrine carcinoma, originally described in the lung.

The tumor rarely occurs in extrapulmonary sites like the gastrointestinal tract, and only few examples have been described in the ampulla of Vater.

A new case of large-cell neuroendocrine carcinoma of the ampulla of Vater in a 60-year-old man is reported.

After pancreatoduodenectomy, macroscopic examination revealed ulcerated tumor in the region of the ampulla of Vater.

Two months after surgery, liver metastases occurred, confirming highly aggressive behavior of large-cell neuroendocrine carcinoma.

[MeSH-major] Ampulla of Vater / pathology. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology. Liver Neoplasms / secondary

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(PMID = 19898974.001).

[ISSN] 1559-131X

[Journal-full-title] Medical oncology (Northwood, London, England)

[ISO-abbreviation] Med. Oncol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pancreaticoduodenectomy is curative in the majority of patients with node-negative ampullary cancer.

HYPOTHESIS: Survival following resection for ampullary carcinoma may be influenced by 1 or more clinical or pathologic variables.

PATIENTS: From July 1, 1991, through April 30, 2004, 72 patients (31 males and 41 females) were treated for ampullary carcinoma at Loyola University Medical Center, Maywood, Ill.

INTERVENTIONS: Whipple procedure for attempted cure in 51 patients with ampullary adenocarcinoma.

CONCLUSION: Pancreaticoduodenectomy is curative in 80% of patients with node-negative ampullary carcinomas.

[MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater. Blood Loss, Surgical. Female. Humans. Lymph Nodes / pathology. Male. Middle Aged. Retrospective Studies. Survival Rate. Time Factors. Treatment Outcome

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[CommentIn] Arch Surg. 2005 Jul;140(7):708 [16027340.001]

(PMID = 15967899.001).

[ISSN] 0004-0010

[Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)

[ISO-abbreviation] Arch Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Exceptional ultra-late recurrence of papilla Vater carcinoma after pancreaticoduodenectomy: two cases at 17 and 25 years.

Cancer of the papilla Vater can remain clinically quiescent for decades prior to regional or distant recurrence.

This protracted disease-free interval challenges the concept of a "cure" for cancer of the papilla Vater.

In the first case reported here, a 74-year-old female underwent pancreaticoduodenectomy in 1985 for cancer of the papilla Vater revealed histologically as a well-differentiated papillotubular adenocarcinoma, stage IA (UICC classification).

The second case is that of an 82-year-old female who underwent pancreaticoduodenectomy in 1974 for cancer of the papilla Vater, histologically a well-differentiated adenocarcinoma, stage IA.

In the 25.5 years after the operation, the cancer recurred at the choledochoduodenal anastomosis and involved the liver hilus.

The ultra-late recurrences (>15 years) in these cases are highly exceptional and, to our knowledge, this is the first report of such recurrences in cancer of the papilla Vater.

Because cancer of the papilla Vater can recur in many prognostically favorable cases after prolonged disease-free intervals, the possibility of delayed recurrence should not be ignored.

[MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater / surgery. Neoplasm Recurrence, Local / diagnosis. Pancreaticoduodenectomy. Postoperative Complications / diagnosis

[MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Biopsy. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Female. Follow-Up Studies. Humans. Liver / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lymphatic Metastasis. Tomography, X-Ray Computed

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(PMID = 15966237.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer.

BACKGROUND: Osteonectin has been suggested to be important in the progression of pancreatic cancer but has not been correlated with survival.

We determined the osteonectin expression and its influence on survival in patients with ampullary carcinoma.

METHODS: Tissue microarrays were constructed from the tumors of 56 patients with ampullary cancer undergoing pancreaticoduodenectomy.

Median follow-up for all living patients with ampullary cancer was 69.6 months.

RESULTS: Osteonectin was significantly (P < .05, Fisher's exact test) overexpressed in the stroma of ampullary cancers (90%) relative to chronic pancreatitis (62%) and normal pancreas (0%).

CONCLUSIONS: Although the importance of tumor-stroma interactions in periampullary cancers is not fully understood, our data suggest that osteonectin is an integral stromal element in ampullary cancers, and its overexpression is associated with decreased survival.

[MeSH-major] Adenocarcinoma / chemistry. Ampulla of Vater. Biomarkers, Tumor / analysis. Common Bile Duct Neoplasms / chemistry. Osteonectin / analysis

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(PMID = 17080236.001).

[ISSN] 1068-9265

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Osteonectin; 106441-73-0 / Osteopontin

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Primary acinar cell carcinoma of the ampulla of Vater.

Acinar cell carcinoma of the pancreatobiliary system is a relatively rare malignant neoplasm arising usually in the pancreatic parenchyma.

We experienced a 68-year-old woman who presented with obstructive jaundice due to an ampullary mass 1.0 cm in diameter, detected by abdominal computed tomography and endoscopic examination.

The patient underwent a curative surgical operation, and histopathological examination revealed that the tumor was confined to the ampulla of Vater with no continuity to the pancreatic parenchyma.

The tumor cells showed acinar or tubular arrangement with eosinophilic to basophilic granular cytoplasm, findings identical to those of acinar cell carcinoma of the pancreas.

From these findings, we concluded that the tumor was primary acinar cell carcinoma arising in the ampulla of Vater, probably originating from heterotopic pancreatic tissue.

This is the first reported case of primary acinar cell carcinoma in the ampulla of Vater.

[MeSH-major] Ampulla of Vater. Carcinoma, Acinar Cell / diagnosis. Common Bile Duct Neoplasms / diagnosis

[MeSH-minor] Biopsy. Diagnosis, Differential. Endosonography. Female. Follow-Up Studies. Humans. Middle Aged. Pancreaticoduodenectomy / methods. Tomography, X-Ray Computed

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(PMID = 17701134.001).

[ISSN] 0944-1174

[Journal-full-title] Journal of gastroenterology

[ISO-abbreviation] J. Gastroenterol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [A case of hepatic metastases of ampullary carcinoma which completely responded to intrahepatic infusion of 5-FU with low-dose l-leucovorin].

A 70-year-old man was admitted with an ampullary carcinoma with multiple hepatic metastases.

[MeSH-major] Ampulla of Vater. Duodenal Neoplasms / pathology. Fluorouracil / administration & dosage. Leucovorin / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary

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(PMID = 16121924.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Survival after resection of ampullary carcinoma: a national population-based study.

BACKGROUND: Ampullary cancer is the second most common periampullary cancer, with a resection and survival rate more favorable than that for pancreatic cancer.

Our objective was to complete a population-based analysis of patients undergoing resection for ampullary carcinoma and compare it with outcomes in the published literature.

METHODS: Patients diagnosed with ampullary cancer reported in the Surveillance, Epidemiology, and End Results program (1988-2003) were collected.

RESULTS: Of the 3292 ampullary cancer patients, 1301 (40%) underwent resection.

The cancer registry data showed less early stage disease, higher perioperative mortality, and lower 5-year survival compared with published reports.

CONCLUSIONS: This is the largest population-based analysis of ampullary carcinoma.

Resection rates and survival at the national level are lower, in general, compared with cancer center reports, which may have implications for regionalizing these procedures.

[MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery

[MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Survival Analysis. Survival Rate. Treatment Outcome

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[CommentIn] Ann Surg Oncol. 2008 Jul;15(7):1813-4 [18425553.001]

(PMID = 18369675.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prognostic value of Bax, Bcl-2, p53, and TUNEL staining in patients with radically resected ampullary carcinoma.

BACKGROUND: There is a lack of data in the literature concerning the identification of potential prognostic factors in ampullary adenocarcinoma.

AIMS: To examine the prognostic significance of Bax, Bcl-2, and p53 protein expression and the apoptotic index in a large cohort of uniformly treated patients with radically resected ampullary cancer.

METHODS: All patients with a pathological diagnosis of ampullary cancer and radical resection were evaluated.

RESULTS: Thirty nine tumour specimens from patients with radically resected ampullary adenocarcinoma were studied.

CONCLUSIONS: These results provide evidence that apoptosis may be an important prognostic factor in patients with radically resected ampullary cancer.

This study is the first to assess the clinical usefulness of Bax expression in radically resected ampullary cancer.

[MeSH-major] Adenocarcinoma / chemistry. Ampulla of Vater. Common Bile Duct Neoplasms / chemistry. In Situ Nick-End Labeling / methods. Proto-Oncogene Proteins c-bcl-2 / analysis. Tumor Suppressor Protein p53 / analysis

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[Cites] Int J Cancer. 1992 Feb 20;50(4):528-32 [1537617.001]

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(PMID = 15677536.001).

[ISSN] 0021-9746

[Journal-full-title] Journal of clinical pathology

[ISO-abbreviation] J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / BAX protein, human; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein

[Other-IDs] NLM/ PMC1770581

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Survival after pancreaticoduodenectomy for ampullary cancer is not affected by age.

BACKGROUND: Although pancreaticoduodenectomy (PD) provides the best chance of survival for elderly patients with ampullary carcinoma, it is associated with considerable surgical risk.

The aim of the present study was to compare the benefits and risks of pancreaticoduodenectomy as a treatment of ampullary carcinoma between young and elderly patients.

Comparison of the biological aggressiveness of ampullary cancer between old and younger patients was also performed by immunohistochemical study of several prognostic biological markers, including MUC1, MUC2, CK17, and CDX2.

RESULTS: For patients in whom ampullary carcinoma was presumed resectable preoperatively, actuarial survival was significantly poorer in 55 elderly patients because 9 of them did not have PD (the other 46 had PD) than in 101 younger patients (all had PD).

There were no significant differences in MUC1, CK17, MUC2, and CDX2 immunohistochemical staining of ampullary carcinomas between elderly and young patients.

CONCLUSIONS: Our data support the conclusion that ampullary cancers in elderly patients should be treated as aggressively as in younger patients.

[MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / mortality

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(PMID = 20714897.001).

[ISSN] 1432-2323

[Journal-full-title] World journal of surgery

[ISO-abbreviation] World J Surg

[Language] eng

[Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Impact of lymph node metastasis on survival in patients with pathological T1 carcinoma of the ampulla of Vater.

To determine the prognostic factors for patients with pathological T1 (pT1) carcinoma of the ampulla of Vater, 36 consecutive patients with carcinoma of the ampulla of Vater who underwent surgery were retrospectively analyzed in terms of clinicopathological features.

[MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Lymphatic Metastasis

[MeSH-minor] Aged. Chemotherapy, Adjuvant. Female. Humans. Japan / epidemiology. Lymph Node Excision. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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(PMID = 16769538.001).

[ISSN] 1091-255X

[Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

[ISO-abbreviation] J. Gastrointest. Surg.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] DNA mismatch repair deficiency in ampullary carcinoma: a morphologic and immunohistochemical study of 54 cases.

The significance of DNA mismatch repair (MMR) deficiency or microsatellite instability (MSI) in ampullary carcinomas remains to be defined.

This study evaluated the MMR status in 54 consecutive ampullary adenocarcinomas by immunohistochemical and morphologic studies.

Thus, MMR deficiency occurs in ampullary carcinoma but appears less frequent than in colorectal carcinoma (CRC).

Typical MSI-high histologic features of CRC, such as increased TIL counts, seem to have similar yet subtly different implications in ampullary carcinoma.

[MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair / genetics. Nuclear Proteins

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(PMID = 20395525.001).

[ISSN] 1943-7722

[Journal-full-title] American journal of clinical pathology

[ISO-abbreviation] Am. J. Clin. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [A case of advanced ampullary carcinoma successfully resected after primary chemotherapy with s-1 and gemcitabine].

He was diagnosed as having advanced ampullary carcinoma(T4 N0 H1, Stage IV b).

This is a very instructive case for developing effective chemotherapy options to treat biliary tract cancers involving ampullary carcinoma.

[MeSH-major] Ampulla of Vater. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Duodenal Neoplasms / drug therapy

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(PMID = 19542724.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 0W860991D6 / Deoxycytidine; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; B76N6SBZ8R / gemcitabine

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.

Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma.

METHODS: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study.

MMP-2 expression was detected in the distal part of the biliary ducts, in 75% (6/18) of cases and in the nontumoral epithelia of the ampullary region in 50% (5/10) of cases.

The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors.

The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively.

MMP-9 and MMP- 14 were present in metaplasia, dysplasia carcinoma sequence in all of the bile tract tumors, suggesting that MMPs play an important role in carcinogenesis.

[MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Ampulla of Vater / enzymology. Ampulla of Vater / pathology. Disease Progression. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Hepatic Duct, Common / enzymology. Hepatic Duct, Common / pathology. Humans. Immunohistochemistry. Klatskin Tumor / metabolism. Klatskin Tumor / pathology. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness. Prognosis

Genetic Alliance. consumer health - Intrahepatic cholangiocarcinoma.

Genetic Alliance. consumer health - Klatskin tumor.

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(PMID = 19330734.001).

[ISSN] 2148-5607

[Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

[ISO-abbreviation] Turk J Gastroenterol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Turkey

[Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.80 / Matrix Metalloproteinase 14

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Carcinoma of the papilla of Vater. Diagnostic and therapeutic problems. An analysis of 32 Tunisian cases].

[Transliterated title] Carcinome de l'ampoule de Vater: problémes diagnostiques et therapeutiques. Analyse d'une série de 32 patients.

The aim determine the clinical, morphological, endoscopical and progressive profile of patients with ampullary carcinoma.

PATIENTS AND METHODS: Thirty-two patients with a carcinoma of the ampulla of Vater, hospitalised in the Gastro-enterology service of Habib Thameur Hospital (Tunis) (1992-2002) have been analysed retrospectively.

Twelve patients (37%) had had a cholecystectomy into the 3 years preceding the diagnosis of the ampullary carcinoma.

After endoscopical sphincterectomy, an intra-ampullar exophytic tumour had been found in I case and an infiltrated aspect of the ampulla of Vater in 2 cases.

The use of lateral duodenoscopy allowed carrying the positive diagnosis in all cases.

Five patients had metastasis at the moment of diagnosis.

CONCLUSION: The ampullary carcinoma is a rare tumour diagnosed belated.

[MeSH-major] Ampulla of Vater. Carcinoma / diagnosis. Carcinoma / therapy. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / therapy

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(PMID = 17294894.001).

[ISSN] 0041-4131

[Journal-full-title] La Tunisie médicale

[ISO-abbreviation] Tunis Med

[Language] fre

[Publication-type] English Abstract; Journal Article

[Publication-country] Tunisia

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Neuroendocrine carcinoma of the ampulla of Vater: a clinicopathologic evaluation.

BACKGROUND: Only 105 cases of neuroendocrine tumor (NET) of the ampulla of Vater have been described, mostly as single case reports.

This study was to determine the relative incidence and clinicopathological characteristics of high-grade neuroendocrine carcinoma (small cell carcinoma and large cell carcinoma) of the ampulla of Vater at a single institution.

METHODS: Sections from paraffin blocks of tumors of the ampulla of Vater taken from 45 patients who underwent Whipple's procedure and 6 patients who underwent palliative bypass between September 2003 and January 2007 were subjected to immunohistochemical analysis.

The clinical and pathological data from 5 patients diagnosed with NET of the ampulla of Vater were analyzed.

Histopathological examination revealed large cell neuroendocrine carcinoma in 2 patients, small cell carcinoma in 2, and carcinoid in 1.

Three patients with high-grade neuroendocrine carcinoma who had undergone Whipple's procedure died at postoperatively 7, 11, and 13 months.

CONCLUSIONS: The relative incidence of high-grade neuroendocrine carcinomas of the ampulla of Vater is higher than that generally expected.

[MeSH-major] Ampulla of Vater. Carcinoma, Large Cell. Carcinoma, Neuroendocrine. Carcinoma, Small Cell. Common Bile Duct Neoplasms

[MeSH-minor] Adult. Biliary Tract Surgical Procedures. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Invasiveness. Palliative Care. Treatment Outcome

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(PMID = 18693180.001).

[ISSN] 1499-3872

[Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT

[ISO-abbreviation] HBPD INT

[Language] eng

[Publication-type] Journal Article

[Publication-country] China

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case.

CASE REPORT: A 30-year-old woman was admitted to our hospital for treatment of an ampullary tumor.

Upper gastrointestinal endoscopy revealed a pedunculated tumor in the ampulla of Vater with a diameter of 50 mm, which was biopsied and diagnosed as tubulovillous adenoma with moderate atypia.

DISCUSSION: Ampullectomy is an established method for ampullary tumor, but such a tumor with a long stalk is rare.

[MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology

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(PMID = 20012229.001).

[ISSN] 1941-6636

[Journal-full-title] Journal of gastrointestinal cancer

[ISO-abbreviation] J Gastrointest Cancer

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis.

BACKGROUND: Allogeneic blood transfusion (ABT) containing packed red blood cells (RBCs) has a known immunosuppressive effect that may affect cancer metastases and recurrence.

This study examined whether intraoperative allogeneic RBC transfusion is an independent risk factor of adverse outcome in patients with ampullary carcinoma after curative pancreatoduodenectomy.

METHODS: The clinical data of 67 patients with carcinoma of the ampulla of Vatar underwent pancreatoduodenectomy between 1999 and 2004 were analyzed, and long-term follow-up visits were made for all patients.

For the meta-analysis, all English-language studies regarding blood transfusion from carcinoma of the ampulla of Vatar or ampullary carcinoma and prognostic factors or factors for survival from 1995 to 2007 were reviewed, and contingency tables were constructed from which a summary relative risk was calculated.

After multivariate analysis, except for presence of lymph node metastasis (P = 0.023) and pancreatic invasion (P = 0.024), the intraoperative ABT > or =3 units was found to be an independent poor prognostic factor for those with ampullary cancer after curative pancreatoduodenectomy either (relative risk, 2.082; 95% confidence interval (CI), 1.048-4.135; P = 0.036).

CONCLUSIONS: The amount of intraoperative ABT is one of the important factors that adversely influenced survival in patients with ampullary cancer after curative pancreatoduodenectomy.

[MeSH-major] Ampulla of Vater / surgery. Erythrocyte Transfusion. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy

[MeSH-minor] Adult. Aged. Blood Loss, Surgical. Blood Transfusion, Autologous. Chi-Square Distribution. Female. Humans. Intraoperative Care. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models. Risk Factors. Survival Analysis. Treatment Outcome

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(PMID = 18584239.001).

[ISSN] 0364-2313

[Journal-full-title] World journal of surgery

[ISO-abbreviation] World J Surg

[Language] eng

[Publication-type] Journal Article; Meta-Analysis

[Publication-country] United States

   

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Large cell neuroendocrine carcinoma of the ampulla of vater: Report of a case.

Large cell neuroendocrine carcinoma in the ampulla of Vater is rare and very different from the common ampullary adenocarcinoma.

Gastroendoscopy showed a swollen ampulla of Vater and pathological examination of an ampullary biopsy revealed findings of a carcinoid tumor.

A diagnosis of large cell neuroendocrine carcinoma was confirmed by immunohistochemical examination of the resected specimen.

[MeSH-major] Ampulla of Vater. Carcinoma, Large Cell / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology

[MeSH-minor] Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Fatal Outcome. Humans. Male. Middle Aged. Pancreaticoduodenectomy

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(PMID = 17072731.001).

[ISSN] 0941-1291

[Journal-full-title] Surgery today

[ISO-abbreviation] Surg. Today

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan