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1
ampulla vater cancer carcinoma 2005:2010[pubdate] *count=100
294 results
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ampulla vater cancer carcinoma
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Items 1 to 100 of about 294
1.
Yeh CC, Jeng YM, Ho CM, Hu RH, Chang HP, Tien YW:
Survival after pancreaticoduodenectomy for ampullary cancer is not affected by age.
World J Surg
; 2010 Dec;34(12):2945-52
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[Title]
Survival after pancreaticoduodenectomy for
ampullary
cancer
is not affected by age.
BACKGROUND: Although pancreaticoduodenectomy (PD) provides the best chance of survival for elderly patients with
ampullary
carcinoma
, it is associated with considerable surgical risk.
The aim of the present study was to compare the benefits and risks of pancreaticoduodenectomy as a treatment
of ampullary
carcinoma
between young and elderly patients.
Comparison of the biological aggressiveness
of ampullary
cancer
between old and younger patients was also performed by immunohistochemical study of several prognostic biological markers, including MUC1, MUC2, CK17, and CDX2.
RESULTS: For patients in whom
ampullary
carcinoma
was presumed resectable preoperatively, actuarial survival was significantly poorer in 55 elderly patients because 9 of them did not have PD (the other 46 had PD) than in 101 younger patients (all had PD).
There were no significant differences in MUC1, CK17, MUC2, and CDX2 immunohistochemical staining
of ampullary
carcinomas between elderly and young patients.
CONCLUSIONS: Our data support the conclusion that
ampullary
cancers in elderly patients should be treated as aggressively as in younger patients.
[MeSH-major]
Adenocarcinoma / surgery.
Ampulla
of
Vater
. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / mortality
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[Cites]
Ann Surg. 1998 Jun;227(6):821-31
[
9637545.001
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[Cites]
Ann Surg Oncol. 2005 Dec;12(12):955-6
[
16228813.001
]
[Cites]
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[
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]
[Cites]
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[
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[Cites]
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[
8098202.001
]
[Cites]
J Clin Oncol. 2005 Mar 20;23(9):1811-8
[
15774774.001
]
(PMID = 20714897.001).
[ISSN]
1432-2323
[Journal-full-title]
World journal of surgery
[ISO-abbreviation]
World J Surg
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
2.
Khaimook A, Borkird J, Alapach S:
The first successful laparoscopic Whipple procedure at Hat Yai Hospital: surgical technique and a case report.
J Med Assoc Thai
; 2010 Sep;93(9):1098-102
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Whipple procedure is the most complex abdominal surgical procedure to treat periampullary
carcinoma
.
The patient was a 40-year-old, Thai-Muslim female, with the
diagnosis of ampullary
carcinoma
.
[MeSH-major]
Adenocarcinoma / surgery.
Ampulla
of
Vater
/ surgery. Common Bile Duct Neoplasms / surgery. Laparoscopy / methods. Pancreaticoduodenectomy / methods
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(PMID = 20873085.001).
[ISSN]
0125-2208
[Journal-full-title]
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
[ISO-abbreviation]
J Med Assoc Thai
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Thailand
3.
Uchida H, Shibata K, Kai S, Iwaki K, Ohta M, Kitano S:
Pylorus-preserving pancreaticoduodenectomy in patients undergoing chronic hemodialysis.
Surg Today
; 2008;38(12):1152-4
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The three cases were diagnosed to have bile duct
cancer
, intraductal papillary mucinous
neoplasm
, and
carcinoma
of the
ampulla
of
Vater
, respectively.
[MeSH-minor]
Aged.
Ampulla
of
Vater
.
Carcinoma
,
Pancreatic
Ductal / epidemiology.
Carcinoma
,
Pancreatic
Ductal / surgery. Common Bile Duct Neoplasms / epidemiology. Common Bile Duct Neoplasms / surgery. Comorbidity. Humans. Kidney Failure, Chronic / epidemiology. Kidney Failure, Chronic / therapy. Length of Stay. Male. Middle Aged
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[Cites]
Ann Surg. 2006 Jul;244(1):10-5
[
16794383.001
]
[Cites]
World J Surg. 2005 Nov;29(11):1409-14
[
16222456.001
]
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[
14769305.001
]
[Cites]
Hepatogastroenterology. 1993 Jun;40(3):249-52
[
8392024.001
]
[Cites]
Am J Kidney Dis. 1991 Sep;18(3):326-35
[
1882824.001
]
[Cites]
Ann Surg. 1935 Oct;102(4):763-79
[
17856666.001
]
[Cites]
J Am Coll Surg. 2003 Aug;197(2):223-31; discussion 231-2
[
12892800.001
]
[Cites]
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[
9880426.001
]
[Cites]
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[
11745817.001
]
[Cites]
Surg Today. 2005;35(5):345-50
[
15864414.001
]
(PMID = 19039646.001).
[ISSN]
0941-1291
[Journal-full-title]
Surgery today
[ISO-abbreviation]
Surg. Today
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
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4.
Umetani N, Kim J, Hiramatsu S, Reber HA, Hines OJ, Bilchik AJ, Hoon DS:
Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats.
Clin Chem
; 2006 Jun;52(6):1062-9
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[Title]
Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary
cancer
: direct quantitative PCR for ALU repeats.
BACKGROUND: Cell-free DNA circulating in blood is a candidate biomarker for
malignant
tumors.
Unlike uniformly truncated DNA released from apoptotic nondiseased cells, DNA released from dead
cancer
cells varies in size.
We developed a novel method to measure the ratio of longer to shorter DNA fragments (DNA integrity) in serum as a potential biomarker for patients with colorectal
cancer
(CRC) or periampullary cancers (PACs).
[MeSH-major]
Ampulla
of
Vater
. Biomarkers, Tumor / blood.
Carcinoma
,
Pancreatic
Ductal /
diagnosis
. Colorectal Neoplasms /
diagnosis
. Common Bile Duct Neoplasms /
diagnosis
. DNA / blood. Duodenal Neoplasms /
diagnosis
.
Pancreatic
Neoplasms /
diagnosis
Genetic Alliance.
consumer health - Colorectal Cancer
.
MedlinePlus Health Information.
consumer health - Colorectal Cancer
.
MedlinePlus Health Information.
consumer health - Intestinal Cancer
.
MedlinePlus Health Information.
consumer health - Pancreatic Cancer
.
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.
The Lens.
Cited by Patents in
.
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(PMID = 16723681.001).
[ISSN]
0009-9147
[Journal-full-title]
Clinical chemistry
[ISO-abbreviation]
Clin. Chem.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 9007-49-2 / DNA
5.
Teo M, Ryan B, Swan N, McDermott RS:
A Case of Metastatic Renal Cell Cancer Presenting as Jaundice.
World J Oncol
; 2010 Oct;1(5):218-220
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[Title]
A Case of Metastatic Renal Cell
Cancer
Presenting as Jaundice.
Renal cell
carcinoma
is the second most common urological malignancy and it runs a highly variable clinical course.
We describe a case of metastatic renal cell
carcinoma
in a 50-year-old lady with metastasis to the
ampulla
of
Vater
, clinically masquerading as cholelithiasis and biliary colic.
Ampullary
metastases are rare, and prompt recognition and intervention are necessary before patient's performance status is compromised.
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[Cites]
BMC Gastroenterol. 2007 Jan 31;7:4
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17266757.001
]
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Surgery. 1996 Mar;119(3):349-51
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]
(PMID = 29147211.001).
[ISSN]
1920-454X
[Journal-full-title]
World journal of oncology
[ISO-abbreviation]
World J Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Canada
[Keywords]
NOTNLM ; Complication / Kidney cancer / Metastasis
6.
Botsios D, Zacharakis E, Lambrou I, Tsalis K, Christoforidis E, Kalfadis S, Zacharakis E, Betsis D, Dadoukis I:
Our local experience with the surgical treatment of ampullary cancer.
Int Semin Surg Oncol
; 2005 Aug 30;2:16
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[Title]
Our local experience with the surgical treatment
of ampullary
cancer
.
BACKGROUND: The aim of this study is to report the outcome after surgical treatment of 32 patients with
ampullary
cancers from 1990 to 1999.
METHODS: Twenty-one of them underwent pancreaticoduodenectomy and 9 local excision of the
ampullary
lesion.
RESULTS: When the final histological
diagnosis
was compared with the preoperative histological finding on biopsy, accurate
diagnosis
was preoperatively established in 24 patients.
Following local excision of the
ampullary
cancer
, the survival rate at 3 and 5 years was 77.7% and 33.3% respectively.
CONCLUSION: In this series, local resection was a safe option in patients with significant co-morbidity or small
ampullary
tumors less than 2 cm in size, and was associated with satisfactory long-term survival rates.
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[ISSN]
1477-7800
[Journal-full-title]
International seminars in surgical oncology : ISSO
[ISO-abbreviation]
Int Semin Surg Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC1215507
7.
Murakami Y, Uemura K, Sasaki M, Morifuji M, Hayashidani Y, Sudo T, Sueda T:
Duodenal cancer arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for ampullary cancer in familial adenomatous polyposis.
J Gastrointest Surg
; 2005 Mar;9(3):389-92
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[Title]
Duodenal
cancer
arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for
ampullary
cancer
in familial adenomatous polyposis.
We herein report a rare occurrence of duodenal
cancer
arising from the remaining duodenum after pylorus-preserving pancreatoduodenectomy for
ampullary
cancer
in familial adenomatous polyposis (FAP).
During the current admission, the patient was diagnosed with adenocarcinoma in the
Vater
's
ampulla
using imaging and pathological examinations.
[MeSH-minor]
Adult.
Ampulla
of
Vater
/ pathology. Cholangiopancreatography, Endoscopic Retrograde / methods. Duodenoscopy / methods. Female. Follow-Up Studies. Humans.
Neoplasm
, Residual / pathology.
Neoplasm
, Residual / surgery. Pylorus. Risk Assessment. Treatment Outcome
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.
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.
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.
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(PMID = 15749602.001).
[ISSN]
1091-255X
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
8.
Katsinelos P, Kountouras J, Chatzimavroudis G, Zavos C, Paroutoglou G, Kotakidou R, Panagiotopoulou K, Papaziogas B:
A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection.
Surg Laparosc Endosc Percutan Tech
; 2007 Dec;17(6):533-7
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[Title]
A case of early depressed-type
ampullary
carcinoma
treated by wire-guided endoscopic resection.
A 72-year-old man, with known prostate
cancer
, was admitted to our endoscopic unit for further evaluation of an obstruction at major
papilla
level.
Endoscopic cholangiopancreatography revealed a depressed-type
carcinoma
at the
ampulla
of
Vater
and dilation of both the common bile and
pancreatic
ducts without intraductal filling defects.
Intraductal ultrasonography showed a hypoechoic mass limited to the
ampulla
of
Vater
.
Histologic examination of the resected specimen showed a completely excised well-differentiated adenocarcinoma limited to the
ampulla
of
Vater
.
Both accurate preoperative staging and proper histologic evaluation of the resected specimen seem to justify endoscopic treatment of early
ampullary
cancer
by an experienced endoscopist.
[MeSH-major]
Adenocarcinoma / surgery.
Ampulla
of
Vater
/ surgery. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods
[MeSH-minor]
Aged. Cholangiopancreatography, Endoscopic Retrograde. Endosonography. Humans. Male.
Neoplasm
Staging. Treatment Outcome
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(PMID = 18097317.001).
[ISSN]
1530-4515
[Journal-full-title]
Surgical laparoscopy, endoscopy & percutaneous techniques
[ISO-abbreviation]
Surg Laparosc Endosc Percutan Tech
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
9.
Terada T:
Primary Pure Squamous Cell Carcinoma of the Duodenum: A Case Report.
Gastroenterology Res
; 2010 Feb;3(1):39-40
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[Title]
Primary Pure Squamous Cell
Carcinoma
of the Duodenum: A Case Report.
: Only two cases of squamous cell
carcinoma
of the duodenum have been reported in the literature.
The author herein reports a case of squamous cell
carcinoma
of the duodenum.
The tumor was circumferential elevated one with duodenal obstruction, and located in the descending part near and distal to the
ampulla
of
Vater
.
The duodenal tumor was different from
ampullary
tumor and
pancreatic
tumor.
All the six biopsies showed
malignant
cells arranged in a medullary pattern.
The
malignant
cells showed hyperchromatic nuclei, and mitotic figures were scattered.
The pathologic features were interpreted as a squamous cell
carcinoma
of the duodenum.
The
carcinoma
was pure squamous cell
carcinoma
without differentiation into adenocarcinoma or endocrine
carcinoma
.
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(PMID = 27956983.001).
[ISSN]
1918-2805
[Journal-full-title]
Gastroenterology research
[ISO-abbreviation]
Gastroenterology Res
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Canada
[Keywords]
NOTNLM ; Duodenum / Histopathology / Squamous cell carcinoma
10.
Scélo G, Boffetta P, Hemminki K, Pukkala E, Olsen JH, Andersen A, Tracey E, Brewster DH, McBride ML, Kliewer EV, Tonita JM, Pompe-Kirn V, Chia KS, Jonasson JG, Martos C, Colin D, Brennan P:
Associations between small intestine cancer and other primary cancers: an international population-based study.
Int J Cancer
; 2006 Jan 1;118(1):189-96
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[Title]
Associations between small intestine
cancer
and other primary cancers: an international population-based study.
Cancer
of the small intestine is a rare
neoplasm
, and its etiology remains poorly understood.
Analysis of other primary cancers in individuals with small intestine
cancer
may help elucidate the causes of this
neoplasm
and the underlying mechanisms.
We included 10,946 cases of first primary small intestine
cancer
from 13
cancer
registries in a pooled analysis.
The observed numbers of 44 types of second primary
cancer
were compared to the expected numbers derived from the age-, gender- and calendar period-specific
cancer
incidence rates in each registry.
We also calculated the standardized incidence ratios (SIR) for small intestine
cancer
as a second primary after other cancers.
There was a 68% overall increase in the risk of a new primary
cancer
after small intestine
carcinoma
(SIR = 1.68, 95% confidence interval [CI] = 1.47-1.71), that remained constant over time.
Significant (p < 0.05) increases were observed for cancers of the oropharynx, colon, rectum,
ampulla
of
Vater
, pancreas, corpus uteri, ovary, prostate, kidney, thyroid gland, skin and soft tissue sarcomas.
Small intestine
cancer
as a second primary was increased significantly after all these cancers, except after oropharyngeal and kidney cancers.
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[Copyright]
Copyright 2005 Wiley-Liss, Inc.
(PMID = 16003748.001).
[ISSN]
0020-7136
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / R03 CA101442-02
[Publication-type]
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
[Publication-country]
United States
11.
Morise Z, Sugioka A, Tokoro T, Tanahashi Y, Okabe Y, Kagawa T, Takeura C:
Surgery and chemotherapy for intrahepatic cholangiocarcinoma.
World J Hepatol
; 2010 Feb 27;2(2):58-64
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However, locoregional extension of these tumors is usually advanced with intrahepatic and lymph-node metastases at the time
of diagnosis
.
Only a small number of ICC cases, accompanied with ECC, gall bladder
carcinoma
, and
ampullary
carcinoma
, have been reported in the studies of chemotherapy due to the rarity of the disease.
However, in some reports, significant anti-
cancer
effects were achieved with a response rate of up to 40% and a median survival of one year.
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(PMID = 21160974.001).
[ISSN]
1948-5182
[Journal-full-title]
World journal of hepatology
[ISO-abbreviation]
World J Hepatol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
China
[Other-IDs]
NLM/ PMC2998957
[Keywords]
NOTNLM ; Chemotherapy / Intrahepatic cholangiocarcinoma / Surgery
12.
Stojsic Z, Brasanac D, Bilanovic D, Mitrovic O, Stevanovic R, Boricic I:
Large-cell neuroendocrine carcinoma of the ampulla of Vater.
Med Oncol
; 2010 Dec;27(4):1144-8
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[Title]
Large-cell neuroendocrine
carcinoma
of the
ampulla
of
Vater
.
Large-cell neuroendocrine
carcinoma
is a high-grade neuroendocrine
carcinoma
, originally described in the lung.
The tumor rarely occurs in extrapulmonary sites like the gastrointestinal tract, and only few examples have been described in the
ampulla
of
Vater
.
A new case of large-cell neuroendocrine
carcinoma
of the
ampulla
of
Vater
in a 60-year-old man is reported.
After pancreatoduodenectomy, macroscopic examination revealed ulcerated tumor in the region of the
ampulla
of
Vater
.
Two months after surgery, liver metastases occurred, confirming highly aggressive behavior of large-cell neuroendocrine
carcinoma
.
[MeSH-major]
Ampulla
of
Vater
/ pathology.
Carcinoma
, Large Cell / pathology.
Carcinoma
, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology. Liver Neoplasms / secondary
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(PMID = 19898974.001).
[ISSN]
1559-131X
[Journal-full-title]
Medical oncology (Northwood, London, England)
[ISO-abbreviation]
Med. Oncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
13.
Chong VH, Telisinghe PU, Yapp SK, Jalihal A:
Biliary strictures secondary to tuberculosis and early ampullary carcinoma.
Singapore Med J
; 2009 Mar;50(3):e94-6
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[Title]
Biliary strictures secondary to tuberculosis and early
ampullary
carcinoma
.
Malignancies are important causes and are often unresectable at the time
of diagnosis
.
We report a 67-year-old man with unexpected findings of obstructive jaundice secondary to biliary TB and an early
ampullary
tumour.
[MeSH-minor]
Aged.
Ampulla
of
Vater
/ pathology. Biliary Tract Surgical Procedures. Constriction, Pathologic / pathology. Humans. Male. Risk Factors
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(PMID = 19352560.001).
[ISSN]
0037-5675
[Journal-full-title]
Singapore medical journal
[ISO-abbreviation]
Singapore Med J
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Singapore
14.
Riediger H, Makowiec F, Fischer E, Adam U, Hopt UT:
Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection.
J Gastrointest Surg
; 2006 Sep-Oct;10(8):1106-15
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Between July 1994 and December 2004, 222 PD (78% pylorus preserving, 19% Whipple, and 3% total pancreatectomy) were performed for
malignant
disease.
Long-term survival was analyzed in 165 patients with
pancreatic
(n = 110),
ampullary
(n = 33), or distal bile (n = 22) duct
cancer
using univariate (log-rank) and multivariate (Cox regression) methods.
Five-year survival rates were 15% in
cancer
of the
pancreatic
head, 22% in
ampullary
cancer
, and 24% in distal bile duct
cancer
(P = 0.02).
Univariate survival analysis of the 110 patients with
cancer
of the
pancreatic
head revealed that a histologically undifferentiated tumor (P = 0.05) and positive resection margins (P = 0.02) were associated with a poorer survival.
In case of tumor adherence or infiltration, combined resection of the
pancreatic
head and the vein should always be considered in the absence of other contraindications for resection.
[MeSH-major]
Mesenteric Veins / pathology. Mesenteric Veins / surgery.
Pancreatic
Neoplasms. Pancreaticoduodenectomy / methods. Portal Vein / pathology. Portal Vein / surgery. Vascular Surgical Procedures / methods
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Morbidity / trends.
Neoplasm
Invasiveness. Postoperative Period. Prospective Studies. Survival Rate. Time Factors. Treatment Outcome
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[ISSN]
1091-255X
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study
[Publication-country]
United States
15.
Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, Furuse J, Saito H, Tsuyuguchi T, Yamamoto M, Kayahara M, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Hirano S, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology:
Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment.
J Hepatobiliary Pancreat Surg
; 2008;15(1):41-54
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[Title]
Guidelines for the management of biliary tract and
ampullary
carcinomas: surgical treatment.
The only curative treatment in biliary tract
cancer
is surgical treatment.
Although hepatectomy and/or pancreaticoduodenectomy are preferable for the curative resection of bile duct
cancer
, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict
diagnosis of
its local extension.
Prognostic factors after resection for bile duct
cancer
include positive surgical margins, especially in the ductal stump; lymph node metastasis; perineural invasion; and combined vascular resection due to portal vein and/or hepatic artery invasion.
For patients with suspected gallbladder
cancer
, laparoscopic cholecystectomy is not recommended, and open cholecystectomy should be performed as a rule.
When gallbladder
cancer
invading the subserosal layer or deeper has been detected after simple cholecystectomy, additional resection should be considered.
Prognostic factors after resection for gallbladder
cancer
include the depth of mural invasion; lymph node metastasis; extramural extension, especially into the hepatoduodenal ligament; perineural invasion; and the degree of curability.
Pancreaticoduodenectomy is indicated for
ampullary
carcinoma
, and limited operation is also indicated for
carcinoma
in adenoma.
The prognostic factors after resection for
ampullary
carcinoma
include lymph node metastasis,
pancreatic
invasion, and perineural invasion.
[MeSH-major]
Ampulla
of
Vater
/ surgery. Biliary Tract Neoplasms / surgery.
Carcinoma
/ surgery
[MeSH-minor]
Biliary Tract / pathology. Biliary Tract Surgical Procedures / methods. Evidence-Based Medicine / methods. Humans.
Neoplasm
Staging. Preoperative Care / methods. Survival Rate
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(PMID = 18274843.001).
[ISSN]
0944-1166
[Journal-full-title]
Journal of hepato-biliary-pancreatic surgery
[ISO-abbreviation]
J Hepatobiliary Pancreat Surg
[Language]
eng
[Publication-type]
Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
[Publication-country]
Japan
[Other-IDs]
NLM/ PMC2794356
[Investigator]
Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
16.
Peng SY, Hong DF, Liu YB, Tan ZJ, Li JT, Tao F:
[Binding pancreaticogastrostomy].
Zhonghua Wai Ke Za Zhi
; 2009 Jan 15;47(2):139-42
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[Source]
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METHODS: From May 2008 to October 2008, 15 patients were performed with BPG, included
pancreatic
head
cancer
in 7 cases, duodenal adenocarcinoma in 2 cases,mass-type chronic pancreatitis with pancreatolithiasis in 1 case,
ampullary
carcinoma
in 1 case, gallbladder
cancer
in 1 case, islet cell tumor in 1 case and cholangiocarcinoma in 2 cases.
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(PMID = 19563012.001).
[ISSN]
0529-5815
[Journal-full-title]
Zhonghua wai ke za zhi [Chinese journal of surgery]
[ISO-abbreviation]
Zhonghua Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
17.
Liu N, Liang H, Li Q, Wang DC, Zhang RP, Wang JC, Hao XS:
[Determinants of long-term survival in 38 patients with carcinoma of ampulla of Vater treated by local resection].
Zhonghua Zhong Liu Za Zhi
; 2005 Oct;27(10):629-31
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[Title]
[Determinants of long-term survival in 38 patients with
carcinoma
of
ampulla
of
Vater
treated by local resection].
OBJECTIVE: To investigate determinants of long-term survival for
carcinoma
of
ampulla
of
Vater
treated by local resection.
On deciding for resection, the common bile duct was probe explored which guided the circumferential ring resection 1 cm, away from the tumor, including all layers of duodenum, ampula and partial bile and terminal
pancreatic
ducts and the posterial wall of duodenum was completed in steps.
Meticulous care was taken not to suture the
pancreatic
duct and endotheliation was ensured at the mouth of common bile duct and duodenum.
Preferably it is indicated only in high risk patients with a pT1 and well differentiated
ampullary
cancer
smaller than 1 cm in diameter.
[MeSH-major]
Adenocarcinoma / surgery.
Ampulla
of
Vater
/ surgery. Common Bile Duct Neoplasms / surgery
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(PMID = 16438877.001).
[ISSN]
0253-3766
[Journal-full-title]
Zhonghua zhong liu za zhi [Chinese journal of oncology]
[ISO-abbreviation]
Zhonghua Zhong Liu Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
18.
Das P, Wolff RA, Abbruzzese JL, Varadhachary GR, Evans DB, Vauthey JN, Baschnagel A, Delclos ME, Krishnan S, Janjan NA, Crane CH:
Concurrent capecitabine and upper abdominal radiation therapy is well tolerated.
Radiat Oncol
; 2006;1:41
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These patients included 28 (32%) with
pancreatic
adenocarcinoma, 18 (20%) with cholangiocarcinoma, 11 (13%) with
ampullary
carcinoma
, 11 (13%) with other primary tumors, 14 (16%) with liver metastases, and 6 (7%) with metastases at other sites.
[MeSH-minor]
Antimetabolites, Antineoplastic / administration & dosage. Capecitabine. Dose-Response Relationship, Radiation. Drug Administration Schedule. Gastrointestinal Neoplasms / drug therapy. Gastrointestinal Neoplasms / radiotherapy. Humans.
Neoplasm
Metastasis. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome
MedlinePlus Health Information.
consumer health - Radiation Therapy
.
COS Scholar Universe.
author profiles
.
Hazardous Substances Data Bank.
CAPECITABINE
.
Hazardous Substances Data Bank.
FLUOROURACIL
.
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[ISSN]
1748-717X
[Journal-full-title]
Radiation oncology (London, England)
[ISO-abbreviation]
Radiat Oncol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
[Other-IDs]
NLM/ PMC1634749
[General-notes]
NLM/ Original DateCompleted: 20070808
19.
Wu LH, Zhang W:
[Prevention and treatment of complications after duodenopancreatectomy].
Di Yi Jun Yi Da Xue Xue Bao
; 2005 Apr;25(4):461-3
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METHODS: The clinical data of 36 cases receiving duodenopancreatectomy during the last decade were analyzed, including 13 cases
of ampullary
carcinoma
, 8 cases of
carcinoma
of the pancreas head, 8 cases of distal cholangiocarcinoma, and 7 cases of
carcinoma
of the duodenal
papilla
.
RESULTS: Complications occurred in 6 cases after duodenopancreatectomy including
pancreatic
fistula in 3 cases, bile duct fistula in 1 case, abdominal cavity hemorrhage in 1 case, and alimentary tract hemorrhage in 1 case, with an incidence rate of postoperative complications of 16.7%; and death occurred in 2 cases.
CONCLUSION: Adequate measures should be taken to reduce such complications as
pancreatic
fistula, bile duct fistula, abdominal cavity hemorrhage, alimentary tract hemorrhage and abdominal cavity infection, and these measures include nutritional support, careful operation in the surgery with adequate drainage, and careful observation and nursing after the surgery.
[MeSH-major]
Pancreatic
Neoplasms / surgery. Pancreaticoduodenectomy / adverse effects. Postoperative Complications / prevention & control
[MeSH-minor]
Adult. Aged. China / epidemiology. Common Bile Duct Neoplasms / surgery. Female. Humans. Male. Middle Aged.
Pancreatic
Fistula / epidemiology.
Pancreatic
Fistula / etiology.
Pancreatic
Fistula / prevention & control
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(PMID = 15837657.001).
[ISSN]
1000-2588
[Journal-full-title]
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
[ISO-abbreviation]
Di Yi Jun Yi Da Xue Xue Bao
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
20.
Sonoue H, Suda K, Nobukawa B, Abe H, Arakawa A, Hirai S, Matsumoto T:
Does ampullary carcinoma arise from distended glands in the papilla of Vater?
J Hepatobiliary Pancreat Surg
; 2008;15(2):161-8
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[Title]
Does
ampullary
carcinoma
arise from distended glands in the
papilla of
Vater
?
BACKGROUND/PURPOSE: Glands near the surface of the
papilla of
Vater
may become distended with mucus and become hyperplastic; that is, become distended.
METHODS: Twenty-nine pancreatoduodenectomized nontumorous duodenal
papilla
specimens from
carcinoma
of the pancreas and bile duct and 34 resected
ampullary
carcinoma
specimens were studied histopathologically and immunohistochemically, using cytokeratins and mucin immunohistochemical features/phenotypes.
Immunopositivity for CK7, CK20, and MUC5AC was found in 25, 21, and 18 of the 34 specimens
of ampullary
carcinoma
, respectively.
CONCLUSIONS: Although most
ampullary
carcinomas arise from the duodenal mucosa or intra-
ampullary
mucosa, both CK7-positive and MUC5AC-positive or only MUC5ACpositive
ampullary
carcinomas may arise from the distended glands.
[MeSH-major]
Ampulla
of
Vater
/ pathology. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology
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(PMID = 18392709.001).
[ISSN]
0944-1166
[Journal-full-title]
Journal of hepato-biliary-pancreatic surgery
[ISO-abbreviation]
J Hepatobiliary Pancreat Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Keratin-7; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins
21.
Bulat C, Bîşca L, Stoian M:
[Tumors of the ampulla of Vater--local or radical resection?].
Rev Med Chir Soc Med Nat Iasi
; 2006 Jul-Sep;110(3):609-12
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[Title]
[Tumors of the
ampulla
of
Vater
--local or radical resection?].
[Transliterated title]
Tumorile benigne ale ampulei lui
Vater
--rezecţie locală sau radicală?
Duodenal
ampulla
is a complex anatomical and histological site and a tumor may arise from one of three types of epithelium: duodenal mucosa,
pancreatic
duct and distal common bile duct.
Benign adenomas appear to be a frequent precursor of
carcinoma
of the
ampulla
of
Vater
, therefore, a local resection can lead to an under treated early
cancer
which would have benefited from a radical excision, with a much better long term result.
[MeSH-major]
Adenoma / surgery.
Ampulla
of
Vater
.
Carcinoma
/ surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery
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(PMID = 17571553.001).
[ISSN]
0048-7848
[Journal-full-title]
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
[ISO-abbreviation]
Rev Med Chir Soc Med Nat Iasi
[Language]
rum
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Romania
22.
Haddad LB, Scatton O, Randone B, Andraus W, Massault PP, Dousset B, Soubrane O:
Pancreatic fistula after pancreaticoduodenectomy: the conservative treatment of choice.
HPB (Oxford)
; 2009 May;11(3):203-9
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[Title]
Pancreatic
fistula after pancreaticoduodenectomy: the conservative treatment of choice.
BACKGROUND: A
pancreatic
fistula (PF) is the most common complication after pancreaticoduodenectomy (PD), and its reported incidence varies from 2% to 28%.
The main indications for PD were
pancreatic
duct
carcinoma
in 52 patients (44.5%),
ampullary
carcinoma
or adenoma in 18 (15.4%) and islet cell tumour in 11 (9.4%).
The medium delay between the
pancreatic
resection and reoperation was 10 days (range, 3-32 days).
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]
(PMID = 19590648.001).
[ISSN]
1365-182X
[Journal-full-title]
HPB : the official journal of the International Hepato Pancreato Biliary Association
[ISO-abbreviation]
HPB (Oxford)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2697888
[Keywords]
NOTNLM ; pancreatic fistula / pancreatic resection / pancreaticoduodenectomy / postoperative complications
23.
Tien YW, Yeh CC, Wang SP, Hu RH, Lee PH:
Is blind pancreaticoduodenectomy justified for patients with ampullary neoplasms?
J Gastrointest Surg
; 2009 Sep;13(9):1666-73
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[Title]
Is blind pancreaticoduodenectomy justified for patients with
ampullary
neoplasms?
BACKGROUND: Many specialists justify pancreaticoduodenectomy (PD) for
pancreatic
head neoplasms with suspected but unproven malignance (blind-PD).
Our aim in this study was to determine whether blind-PD is also justified for
ampullary
neoplasms.
METHODS: We retrospectively reviewed the records of all patients with presumed resectable
ampullary
neoplasms treated at the National Taiwan University Hospital from 1998 to 2008.
RESULTS: Of the 84 patients without a preoperative tissue
diagnosis of
malignance, 64 had blind-PD and 20 had ampullectomy (AMP) with intraoperative frozen section.
Final pathological
diagnosis
was benign in ten of 64 blind-PD-treated patients.
CONCLUSIONS: Our data support a selective use of blind-PD because (1) a significant portion (65%) of benign
ampullary
neoplasms can be safely and effectively treated by AMP, (2) blind-PD does not treat
ampullary
cancer
at earlier stage, and (3) blind-PD is associated with significantly more complications and significantly longer hospital stay than AMP.
However, blind-PD is strongly recommended for patients with large
ampullary
neoplasms (>3 cm in diameter), with jaundice, or with
malignant
endoscopic appearance.
[MeSH-major]
Ampulla
of
Vater
/ pathology.
Pancreatic
Neoplasms / pathology.
Pancreatic
Neoplasms / surgery. Pancreaticoduodenectomy / methods
[MeSH-minor]
Aged. Biopsy, Needle. Cholangiopancreatography, Endoscopic Retrograde / methods. Cohort Studies. Disease-Free Survival. Female. Follow-Up Studies. Hospital Mortality / trends. Humans. Immunohistochemistry. Male. Middle Aged.
Neoplasm
Invasiveness / pathology.
Neoplasm
Staging. Postoperative Complications / mortality. Preoperative Care. Probability. Registries. Retrospective Studies. Risk Assessment. Sphincterotomy, Endoscopic. Statistics, Nonparametric. Survival Rate
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(PMID = 19557483.001).
[ISSN]
1873-4626
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
24.
Barauskas G, Gulbinas A, Pranys D, Dambrauskas Z, Pundzius J:
Tumor-related factors and patient's age influence survival after resection for ampullary adenocarcinoma.
J Hepatobiliary Pancreat Surg
; 2008;15(4):423-8
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[Title]
Tumor-related factors and patient's age influence survival after resection for
ampullary
adenocarcinoma.
BACKGROUND/PURPOSE: The majority of surgeons agree that
ampullary
adenocarcinoma should be removed by partial pancreatoduodenectomy.
Favoring extended resection, based on the uncertainty of the preoperative
diagnosis
and the higher probability of clear resection margins, we aimed to disclose the results of this surgical procedure in terms of postoperative morbidity and mortality, and to identify prognosticators of long-term survival.
METHODS: We documented, prospectively, 25 consecutive patients with adenocarcinoma of the
papilla of
Vater
in whom pylorus-preserving pancreatoduodenectomy was performed.
Clinical data, pathology reports, International Union Against
Cancer
(UICC) tumor stage, postoperative morbidity, mortality, and long-term follow-up results were evaluated.
CONCLUSIONS: Pancreatoduodenectomy for
ampullary
carcinoma
is reasonable in terms of postoperative morbidity and mortality.
[MeSH-major]
Adenocarcinoma / mortality.
Ampulla
of
Vater
. Common Bile Duct Neoplasms / mortality. Pancreaticoduodenectomy
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(PMID = 18670845.001).
[ISSN]
0944-1166
[Journal-full-title]
Journal of hepato-biliary-pancreatic surgery
[ISO-abbreviation]
J Hepatobiliary Pancreat Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Japan
25.
Ahrens W, Mambetova C, Bourdon-Raverdy N, Llopis-González A, Guénel P, Hardell L, Merletti F, Morales-Suárez-Varela M, Olsen J, Olsson H, Vyberg M, Zambon P:
Occupational exposure to endocrine-disrupting compounds and biliary tract cancer among men.
Scand J Work Environ Health
; 2007 Oct;33(5):387-96
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[Title]
Occupational exposure to endocrine-disrupting compounds and biliary tract
cancer
among men.
OBJECTIVES: This study investigated the association between
cancer
of the extrahepatic biliary tract and exposure to endocrine-disrupting compounds.
METHODS: Altogether 183 men with histologically confirmed
carcinoma
of the extrahepatic biliary tract and 1938 matched controls were interviewed between 1995 and 1997 in the frame of an international multicenter case-control study in six European countries (Denmark, France, Germany, Italy, Spain, and Sweden).
The elevated risk was restricted to extrahepatic bile ducts and
ampulla
Vateri
(OR 1.7, 95% CI 1.0-2.6).
The adjusted OR for
cancer
of the extrahepatic biliary tract after exposure to polychlorinated biphenyls was 2.8 (95% CI 1.3-5.9, only index participants).
CONCLUSIONS: The data show some associations between exposure to endocrine-disrupting compounds in the workplace and the risk for
cancer
of the extrahepatic biliary tract among men, particularly for the extrahepatic bile duct and
ampulla
of
Vater
.
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[ErratumIn]
Scand J Work Environ Health. 2008 Jun;34(3):234
(PMID = 17973065.001).
[ISSN]
0355-3140
[Journal-full-title]
Scandinavian journal of work, environment & health
[ISO-abbreviation]
Scand J Work Environ Health
[Language]
eng
[Publication-type]
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
[Publication-country]
Finland
[Chemical-registry-number]
0 / Hazardous Substances
26.
Wiedmann M, Schoppmeyer K, Witzigmann H, Hauss J, Mössner J, Caca K:
[Current diagnostics and therapy for carcinomas of the biliary tree and gallbladder].
Z Gastroenterol
; 2005 Mar;43(3):305-15
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Carcinoma
of the biliary tree are rare tumours of the gastrointestinal tract with a rising incidence during the last years.
Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumour, middle and distal extrahepatic tumours), gallbladder
cancer
, and
ampullary
carcinoma
.
Transformation of normal into
malignant
bile duct tissue requires a chain of consecutive gene mutations, similar to the adenoma-dysplasia-
carcinoma
-sequence in colon
cancer
.
Abdominal ultrasound, combined non-invasive magnetic resonance cholangiography/tomography (MRC/MRT), and facultatively endoscopic retrograde cholangiography (ERC) for unclear
diagnosis
, represent the gold standard for primary
diagnosis
.
For
ampullary
carcinoma
, endosonography and endoscopic biopsy are the diagnostic tools of choice.
[MeSH-minor]
Algorithms.
Ampulla
of
Vater
. Bile Ducts / pathology. Bile Ducts, Intrahepatic. Biopsy. Brachytherapy. Cholangiocarcinoma /
diagnosis
. Cholangiocarcinoma / therapy. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms /
diagnosis
. Common Bile Duct Neoplasms / therapy. Cyclooxygenase Inhibitors / therapeutic use. Gallbladder / pathology. Hepatectomy. Hepatic Duct, Common. Humans. Klatskin Tumor /
diagnosis
. Klatskin Tumor / therapy. Magnetic Resonance Imaging.
Neoplasm
Staging. Palliative Care. Retrospective Studies. Risk Factors. Stents. Time Factors
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[CommentIn]
Z Gastroenterol. 2005 May;43(5):473-5
[
15871071.001
]
(PMID = 15765304.001).
[ISSN]
0044-2771
[Journal-full-title]
Zeitschrift für Gastroenterologie
[ISO-abbreviation]
Z Gastroenterol
[Language]
ger
[Publication-type]
Comparative Study; English Abstract; Journal Article; Review
[Publication-country]
Germany
[Chemical-registry-number]
0 / Cyclooxygenase Inhibitors
[Number-of-references]
153
27.
Zhang XM, Shen CY, Li W, Zhang XM:
[Surgical treatment of tumor invading important vessel].
Zhonghua Wai Ke Za Zhi
; 2007 Aug 1;45(15):1044-7
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The tumor involving thoraco-abdominal cavity was in one case with
malignant
neuroblastoma.
Tumor located in thoracic cavity were in 13 cases including IVC leiomyosarcoma in 2 cases, thymic
carcinoma
in 3 cases,
malignant
thymoma in 4 cases,
malignant
seminoma of superior mediastinum in 1 case,
malignant
lymphoma in 1 case, lung
cancer
in 2 cases.
The tumor located in abdominal cavity were in 24 cases including renal
carcinoma
with tumor thrombi in 11 cases, inflammatory pseudotumor of retro-peritoneum in 4 cases,
malignant
fibrous histiocytoma of retro-peritoneum in 1 case, non-Hodgkin's disease of retro-peritoneum in 1 case, lymph metastasis of retro-peritoneum in 2 cases, paraganglion tumor of the right adrenal gland in 1 case,
ampullary
carcinoma
in 1 case, leiomyosarcoma of abdominal IVC in 1 case, leiomyosarcoma of pelvic cavity and IVC in 1 cases, fibrosarcoma of pelvic cavity in 1 case.
[MeSH-minor]
Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged.
Neoplasm
Invasiveness. Retrospective Studies. Treatment Outcome. Vena Cava, Inferior / pathology. Vena Cava, Inferior / surgery
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(PMID = 18005586.001).
[ISSN]
0529-5815
[Journal-full-title]
Zhonghua wai ke za zhi [Chinese journal of surgery]
[ISO-abbreviation]
Zhonghua Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
28.
Mizuno T, Ishizaki Y, Ogura K, Yoshimoto J, Kawasaki S:
Clinical significance of immunohistochemically detectable lymph node metastasis in adenocarcinoma of the ampulla of Vater.
Br J Surg
; 2006 Feb;93(2):221-5
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[Title]
Clinical significance of immunohistochemically detectable lymph node metastasis in adenocarcinoma of the
ampulla
of
Vater
.
BACKGROUND: The aim of this study was to assess the impact of immunohistochemically identified lymph node metastasis on survival in patients with
carcinoma
of the
ampulla
of
Vater
.
METHODS: Three hundred and twenty-six regional lymph nodes dissected from pancreatoduodenectomy specimens from 25 patients with
ampulla
of
Vater carcinoma
were immunostained with anticytokeratin antibody (CAM 5.2).
CONCLUSION: Immunostaining of dissected lymph nodes adds additional information to data obtained by conventional haematoxylin and eosin staining when determining the prognosis of patients with
carcinoma
of the
ampulla
of
Vater
.
[MeSH-major]
Adenocarcinoma / secondary.
Ampulla
of
Vater
/ pathology. Common Bile Duct Neoplasms / pathology
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[Copyright]
Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
(PMID = 16363020.001).
[ISSN]
0007-1323
[Journal-full-title]
The British journal of surgery
[ISO-abbreviation]
Br J Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
29.
Palanivelu C, Jani K, Senthilnathan P, Parthasarathi R, Rajapandian S, Madhankumar MV:
Laparoscopic pancreaticoduodenectomy: technique and outcomes.
J Am Coll Surg
; 2007 Aug;205(2):222-30
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RESULTS: The procedure could be completed laparoscopically with tumor-free margins in all patients, including patients with
ampullary
carcinoma
(n = 24),
pancreatic
cystadenocarcinoma (n = 4),
pancreatic
head adenocarcinoma (n = 9), low common bile duct
cancer
(n = 3), and two patients with chronic pancreatitis with a suspicious mass lesion in the head of pancreas.
Five-year actuarial survival rates for all patients with malignancy,
ampullary
adenocarcinoma,
pancreatic
cystadenocarcinoma,
pancreatic
head adenocarcinoma, and common bile duct adenocarcinoma are 32%, 30.7%, 33.3%, 19.1%, and 50%, respectively.
Localized
malignant
lesions, irrespective of histopathology, are particularly amenable to this approach.
[MeSH-major]
Duodenal Neoplasms / surgery. Laparoscopy.
Pancreatic
Neoplasms / surgery. Pancreaticoduodenectomy / methods
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(PMID = 17660068.001).
[ISSN]
1072-7515
[Journal-full-title]
Journal of the American College of Surgeons
[ISO-abbreviation]
J. Am. Coll. Surg.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
30.
Berberat PO, Künzli BM, Gulbinas A, Ramanauskas T, Kleeff J, Müller MW, Wagner M, Friess H, Büchler MW:
An audit of outcomes of a series of periampullary carcinomas.
Eur J Surg Oncol
; 2009 Feb;35(2):187-91
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BACKGROUND: Non-
pancreatic
periampullary
carcinoma
such as
ampullary
carcinoma
(AmpCA), distal cholangiocellular
carcinoma
(CholCA) and duodenal
carcinoma
(DuoCA) have a better prognosis than
pancreatic
head adenocarcinoma (PanCA).
This study describes the outcome and parameters, which predict survival of non-
pancreatic
periampullary
carcinoma
after resection.
METHODS AND PATIENTS: Data from 148 consecutive patients with non-
pancreatic
periampullary carcinomas were recorded prospectively between 1993 and 2005 and analyzed using univariate and multivariate models.
RESULTS: One hundred thirty-three of 148 (90%) patients were resected for histologically proven non-
pancreatic
periampullary carcinomas.
CONCLUSION: Only T1/T2
ampullary
carcinomas have a good prognosis, whereas T3/T4
ampullary
tumors show aggressiveness similar to that
of pancreatic
head adenocarcinomas.
[MeSH-major]
Ampulla
of
Vater
. Biliary Tract Surgical Procedures / methods.
Carcinoma
/ surgery. Clinical Audit / methods. Common Bile Duct Neoplasms / surgery
[MeSH-minor]
Aged. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged.
Neoplasm
Recurrence, Local / epidemiology. Prospective Studies. Survival Rate. Treatment Outcome
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(PMID = 18343082.001).
[ISSN]
1532-2157
[Journal-full-title]
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
[ISO-abbreviation]
Eur J Surg Oncol
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Multicenter Study
[Publication-country]
England
31.
Williams KJ, Picus J, Trinkhaus K, Fournier CC, Suresh R, James JS, Tan BR:
Gemcitabine with carboplatin for advanced biliary tract cancers: a phase II single institution study.
HPB (Oxford)
; 2010 Aug;12(6):418-26
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METHODS: Patients with histologically proven BTCs, including cholangiocarcinoma or gallbladder and
ampullary
carcinomas, were treated with a maximum of nine cycles of intravenous (i.v.) gemcitabine at 1000 mg/m(2) over 30 min on days 1 and 8 with i.v. carboplatin dosed at an area-under-the-curve (AUC) of 5 over 60 min on day 1 of a 21-day cycle.
RESULTS: A total of 48 patients with advanced BTCs (35 cholangiocarcinoma, 12 gallbladder and 1
ampullary
cancer
) were enrolled.
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Ann Oncol. 2001 Feb;12(2):183-6
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11300321.001
]
(PMID = 20662793.001).
[ISSN]
1477-2574
[Journal-full-title]
HPB : the official journal of the International Hepato Pancreato Biliary Association
[ISO-abbreviation]
HPB (Oxford)
[Language]
eng
[Databank-accession-numbers]
ClinicalTrials.gov/ NCT00660140
[Publication-type]
Clinical Trial, Phase II; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin
[Other-IDs]
NLM/ PMC3028583
32.
Nielsen A, Scarlett CJ, Samra JS, Gill A, Li Y, Allen BJ, Smith RC:
Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction.
J Gastroenterol Hepatol
; 2005 Feb;20(2):256-63
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[Title]
Significant overexpression of urokinase-type plasminogen activator in
pancreatic
adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction.
It was hypothesized that uPA would be overexpressed in highly metastatic
pancreatic
cancer
.
The aims of this study were to analyze uPA mRNA expression in
pancreatic
cancer
and to correlate this to the expression of uPA protein and to the stage of the disease.
METHODS: Twenty-one
pancreatic
adenocarcinoma, six
ampullary
carcinoma
and 10 benign mucinous cystadenoma samples, all with adjacent normal tissue, were collected. uPA mRNA was measured using real-time quantitative reverse transcription polymerase chain reaction.
Localization of uPA within normal and
pancreatic
tumor sections was subsequently confirmed using immunohistochemistry.
RESULTS: The median and range of the ratios of uPA mRNA measures between tumor tissue and non-involved
pancreatic
tissue was 17.1 (1.4-653.6) for
pancreatic
adenocarcinoma (P < 0.001), 3.9 (0.7-7.7) for
ampullary
carcinoma
(P = 0.055) and 1.9 (0.6-5.9) for mucinous cystadenoma tissue (P = 0.052).
Immunohistochemistry confirmed that uPA protein was more prevalent in
pancreatic
adenocarcinoma tissue than in normal tissue and that it was membrane-bound. uPA mRNA expression was significantly associated with poorly differentiated
pancreatic
cancers (P < 0.05) and positively associated with tumor stage.
CONCLUSIONS: These observations suggest that significant overexpression of uPA correlates closely to the rapid progression and invasiveness
of pancreatic
cancer
and that uPA may provide a future therapeutic target for
pancreatic
cancer
treatment.
[MeSH-major]
Adenocarcinoma / genetics.
Pancreatic
Neoplasms / genetics. Urokinase-Type Plasminogen Activator / genetics
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[Copyright]
(c) 2004 Blackwell Publishing Asia Pty Ltd.
(PMID = 15683429.001).
[ISSN]
0815-9319
[Journal-full-title]
Journal of gastroenterology and hepatology
[ISO-abbreviation]
J. Gastroenterol. Hepatol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Australia
[Chemical-registry-number]
0 / RNA, Messenger; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
33.
Shao YF, Wu TC, Shan Y, Wu JX, Wang X, Zhao P:
[Clinico-pathological characteristics of surgical effect on periampullary cancers: report of 631 cases].
Zhonghua Yi Xue Za Zhi
; 2005 Mar 2;85(8):510-3
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METHODS: A retrospective study was accomplished on the clinical manifestation, pathological behavior and postoperative survival of 631 patients with periampullary
cancer
hospitalized from Jan 1980 to Dec 2003.
RESULTS: The characteristics of different periampullary cancers, in the order of
carcinoma
of head of pancreas (n = 352),
carcinoma
of common bile duct (n = 42),
carcinoma
of
Vater
's
ampulla
(n = 189), and duodenal
cancer
(n = 48) were as follows:.
[MeSH-major]
Ampulla
of
Vater
. Common Bile Duct Neoplasms / pathology.
Pancreatic
Neoplasms / pathology
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(PMID = 15949327.001).
[ISSN]
0376-2491
[Journal-full-title]
Zhonghua yi xue za zhi
[ISO-abbreviation]
Zhonghua Yi Xue Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
34.
Park S, Kim SW, Lee BL, Jung EJ, Kim WH:
Expression of E-cadherin and beta-catenin in the adenoma-carcinoma sequence of ampulla of Vater cancer.
Hepatogastroenterology
; 2006 Jan-Feb;53(67):28-32
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[Title]
Expression of E-cadherin and beta-catenin in the adenoma-
carcinoma
sequence of
ampulla
of
Vater cancer
.
BACKGROUND/AIMS:
Ampullary
carcinoma
is uncommon but provides a good model for adenoma-
carcinoma
sequence.
During the adenoma-
carcinoma
transition, the tumor cells should acquire the ability to invade.
METHODOLOGY: 111 cases
of ampullary
carcinoma
were investigated with E-cadherin and beta-catenin expression with immunohistochemistry and the result was compared with their clinicopathologic and survival results.
RESULTS: Expressional loss of E-cadherin was detected in 3 (6.1%) adenomas and 73 (65.8%) carcinomas, and the expressional loss was significantly associated with tumor cell differentiation (p<0.05) and survival (p<0.05) in
carcinoma
.
CONCLUSIONS: Alteration of E-cadherin and beta-catenin is a late event during the adenoma-
carcinoma
sequence in
ampullary
neoplasms, and the loss of membranous expression of both E-cadherin and beta-catenin is closely correlated with less differentiated histology and poor prognosis.
[MeSH-major]
Adenoma / metabolism. Adenoma / pathology.
Ampulla
of
Vater
. Cadherins / biosynthesis.
Carcinoma
/ metabolism.
Carcinoma
/ pathology. Common Bile Duct Neoplasms / metabolism. Common Bile Duct Neoplasms / pathology. beta Catenin / biosynthesis
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(PMID = 16506371.001).
[ISSN]
0172-6390
[Journal-full-title]
Hepato-gastroenterology
[ISO-abbreviation]
Hepatogastroenterology
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Greece
[Chemical-registry-number]
0 / Cadherins; 0 / beta Catenin
35.
Hsu HP, Shan YS, Hsieh YH, Yang TM, Lin PW:
Predictors of recurrence after pancreaticoduodenectomy in ampullary cancer: comparison between non-, early and late recurrence.
J Formos Med Assoc
; 2007 Jun;106(6):432-43
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[Title]
Predictors of recurrence after pancreaticoduodenectomy in
ampullary
cancer
: comparison between non-, early and late recurrence.
BACKGROUND/PURPOSE:
Ampullary
cancer
is one of the periampullary cancers with a better prognosis, but relapse still occurs early in some patients.
METHODS: Between January 1989 and March 2006, information was gathered on a total of 127 patients undergoing pancreaticoduodenectomy with regional lymphadenectomy for
ampullary
cancer
at National Cheng Kung University Hospital and Tainan Municipal Hospital.
The early and late recurrence patients had higher levels of microscopically (R1) or macroscopically (R2) positive margin of resection and more advanced disease (advanced tumor stage, numbers of lymph nodes involved, lymph node status,
pancreatic
invasion and TNM stage) than the non-recurrence group.
After multivariate analysis, positive resection margin,
pancreatic
invasion and lymph node involvement were significant predictors for disease recurrence.
CONCLUSION: Positive resection margin,
pancreatic
invasion, and lymph node involvement were found to be predictors for disease recurrence and indicators for postoperative treatment.
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(PMID = 17588836.001).
[ISSN]
0929-6646
[Journal-full-title]
Journal of the Formosan Medical Association = Taiwan yi zhi
[ISO-abbreviation]
J. Formos. Med. Assoc.
[Language]
ENG
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Singapore
36.
Artifon EL, Couto D Jr, Sakai P, da Silveira EB:
Prospective evaluation of EUS versus CT scan for staging of ampullary cancer.
Gastrointest Endosc
; 2009 Aug;70(2):290-6
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[Title]
Prospective evaluation of EUS versus CT scan for staging
of ampullary
cancer
.
BACKGROUND: Malignancies of the biliary and
pancreatic
systems are associated with a poor prognosis.
However,
ampullary
cancer
carries a better prognosis and is often diagnosed when curative treatment is still possible.
(1) To determine the test performance characteristics of EUS and CT in loco-regional staging
of ampullary
neoplasms, and (2) to determine the impact of CT scan results on the test performance characteristics of EUS.
Further studies to determine the role of specialized CT protocols in patients with
ampullary
malignancies are needed.
[MeSH-major]
Adenocarcinoma / pathology.
Ampulla
of
Vater
. Common Bile Duct Neoplasms / pathology. Endosonography. Tomography, X-Ray Computed
[MeSH-minor]
Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged.
Neoplasm
Staging. Prospective Studies
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(PMID = 19523619.001).
[ISSN]
1097-6779
[Journal-full-title]
Gastrointestinal endoscopy
[ISO-abbreviation]
Gastrointest. Endosc.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
37.
Bloomston M, Ellison EC, Muscarella P, Al-Saif O, Martin EW, Melvin WS, Frankel WL:
Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer.
Ann Surg Oncol
; 2007 Jan;14(1):211-7
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[Title]
Stromal osteonectin overexpression is associated with poor outcome in patients with
ampullary
cancer
.
BACKGROUND: Osteonectin has been suggested to be important in the progression
of pancreatic
cancer
but has not been correlated with survival.
We determined the osteonectin expression and its influence on survival in patients with
ampullary
carcinoma
.
METHODS: Tissue microarrays were constructed from the tumors of 56 patients with
ampullary
cancer
undergoing pancreaticoduodenectomy.
Median follow-up for all living patients with
ampullary
cancer
was 69.6 months.
RESULTS: Osteonectin was significantly (P < .05, Fisher's exact test) overexpressed in the stroma
of ampullary
cancers (90%) relative to chronic pancreatitis (62%) and normal pancreas (0%).
CONCLUSIONS: Although the importance of tumor-stroma interactions in periampullary cancers is not fully understood, our data suggest that osteonectin is an integral stromal element in
ampullary
cancers, and its overexpression is associated with decreased survival.
[MeSH-major]
Adenocarcinoma / chemistry.
Ampulla
of
Vater
. Biomarkers, Tumor / analysis. Common Bile Duct Neoplasms / chemistry. Osteonectin / analysis
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(PMID = 17080236.001).
[ISSN]
1068-9265
[Journal-full-title]
Annals of surgical oncology
[ISO-abbreviation]
Ann. Surg. Oncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Osteonectin; 106441-73-0 / Osteopontin
38.
Kawakami H, Kuwatani M, Onodera M, Hirano S, Kondo S, Nakanishi Y, Itoh T, Asaka M:
Primary acinar cell carcinoma of the ampulla of Vater.
J Gastroenterol
; 2007 Aug;42(8):694-7
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The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Primary acinar cell
carcinoma
of the
ampulla
of
Vater
.
Acinar cell
carcinoma
of the pancreatobiliary system is a relatively rare
malignant neoplasm
arising usually in the
pancreatic
parenchyma.
We experienced a 68-year-old woman who presented with obstructive jaundice due to an
ampullary
mass 1.0 cm in diameter, detected by abdominal computed tomography and endoscopic examination.
The patient underwent a curative surgical operation, and histopathological examination revealed that the tumor was confined to the
ampulla
of
Vater
with no continuity to the
pancreatic
parenchyma.
The tumor cells showed acinar or tubular arrangement with eosinophilic to basophilic granular cytoplasm, findings identical to those of acinar cell
carcinoma
of the pancreas.
From these findings, we concluded that the tumor was primary acinar cell
carcinoma
arising in the
ampulla
of
Vater
, probably originating from heterotopic
pancreatic
tissue.
This is the first reported case of primary acinar cell
carcinoma
in the
ampulla
of
Vater
.
[MeSH-major]
Ampulla
of
Vater
.
Carcinoma
, Acinar Cell /
diagnosis
. Common Bile Duct Neoplasms /
diagnosis
[MeSH-minor]
Biopsy.
Diagnosis
, Differential. Endosonography. Female. Follow-Up Studies. Humans. Middle Aged. Pancreaticoduodenectomy / methods. Tomography, X-Ray Computed
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[Cites]
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[
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]
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Gastrointest Endosc. 2001 Jan;53(1):121-3
[
11154509.001
]
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Am J Surg Pathol. 1992 Sep;16(9):815-37
[
1384374.001
]
[Cites]
Arch Pathol Lab Med. 1999 Aug;123(8):707-11
[
10420228.001
]
[Cites]
Am J Clin Oncol. 1997 Feb;20(1):101-7
[
9020300.001
]
[Cites]
Hum Pathol. 2002 Apr;33(4):449-51
[
12055683.001
]
(PMID = 17701134.001).
[ISSN]
0944-1174
[Journal-full-title]
Journal of gastroenterology
[ISO-abbreviation]
J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
39.
Yang YM, Tian XD, Zhuang Y, Wang WM, Wan YL, Huang YT:
Risk factors of pancreatic leakage after pancreaticoduodenectomy.
World J Gastroenterol
; 2005 Apr 28;11(16):2456-61
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[Title]
Risk factors
of pancreatic
leakage after pancreaticoduodenectomy.
AIM: To analyze the risk factors for
pancreatic
leakage after pancreaticoduodenectomy (PD) and to evaluate whether duct-to-mucosa pancreaticojejunostomy could reduce the risk
of pancreatic
leakage.
The primary diseases of the patients included pancreas
cancer
,
ampullary
cancer
, bile duct
cancer
, islet cell
cancer
, duodenal
cancer
, chronic pancreatitis,
pancreatic
cystadenoma, and gastric
cancer
.
A duct-to-mucosa pancreaticojejunostomy was performed for patients with a hard pancreas and a dilated
pancreatic
duct, and a traditional end-to-end invagination pancreaticojejunostomy for patients with a soft pancreas and a non-dilated duct.
Seven preoperative and six intraoperative risk factors with the potential to affect the incidence
of pancreatic
leakage were analyzed with SPSS10.0 software.
Logistic regression was then used to determine the effect of multiple factors on
pancreatic
leakage.
RESULTS: Of the 62 patients, 10 (16.13%) were identified as having
pancreatic
leakage after operation.
The hospital mortality in this series was 4.84% (3/62), and the mortality associated with
pancreatic
fistula was 10% (1/10).
Sixteen cases underwent duct-to-mucosa pancreaticojejunostomy and 1 case (1/16, 6.25%) developed postoperative
pancreatic
leakage, 46 cases underwent invagination pancreaticojejunostomy and 9 cases (9/46, 19.6%) developed postoperative
pancreatic
leakage.
General risk factors including patient age, gender, history of jaundice, preoperative nutrition, pathological
diagnosis
and the length of postoperative stay were similar in the two groups.
There was no statistical difference in the incidence
of pancreatic
leakage between the patients who received the prophylactic use of octreotide after surgery and the patients who did not undergo somatostatin therapy.
Moreover, multivariate logistic regression analysis showed that none of the above factors seemed to be associated with
pancreatic
fistula.
Two intraoperative risk factors,
pancreatic
duct size and texture of the remnant pancreas, were found to be significantly associated with
pancreatic
leakage.
The incidence
of pancreatic
leakage was 4.88% in patients with a
pancreatic
duct size greater than or equal to 3 mm and was 38.1% in those with ducts smaller than 3 mm (P = 0.002).
The
pancreatic
leakage rate was 2.94% in patients with a hard pancreas and was 32.1% in those with a soft pancreas (P = 0.004).
The incidence
of pancreatic
leakage was 6.25% (1/16) in patients with duct-to-mucosa anastomosis, and was 19.6% (9/46) in those with traditional invagination anastomosis.
Although the difference
of pancreatic
leakage between the two groups was obvious, no statistical significance was found.
By further analyzing with multivariate logistic regression, both
pancreatic
duct size and texture of the remnant pancreas were demonstrated to be independent risk factors (P = 0.007 and 0.017, OR = 11.87 and 15.45).
Although anastomotic technique was not a significant factor,
pancreatic
leakage rate was much less in cases that underwent duct-to-mucosa pancreaticojejunostomy.
CONCLUSION:
Pancreatic
duct size and texture of the remnant pancreas are risk factors influencing
pancreatic
leakage after PD.
Duct-to-mucosa pancreaticojejunostomy, as a safe and useful anastomotic technique, can reduce
pancreatic
leakage rate after PD.
[MeSH-major]
Intraoperative Complications / epidemiology.
Pancreatic
Diseases / epidemiology.
Pancreatic
Diseases / surgery. Pancreaticoduodenectomy / adverse effects. Postoperative Complications / epidemiology
[MeSH-minor]
Adult. Aged. Duodenum / surgery. Female. Humans. Male. Middle Aged. Pancreas / surgery.
Pancreatic
Ducts / surgery. Risk Factors
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(PMID = 15832417.001).
[ISSN]
1007-9327
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
China
[Other-IDs]
NLM/ PMC4305634
40.
Tang W, Inagaki Y, Kokudo N, Guo Q, Seyama Y, Nakata M, Imamura H, Sano K, Sugawara Y, Makuuchi M:
KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression.
World J Gastroenterol
; 2005 Sep 21;11(35):5450-4
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[Title]
KL-6 mucin expression in
carcinoma
of the
ampulla
of
Vater
: association with
cancer
progression.
AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in
carcinoma
of the
ampulla
of
Vater
.
METHODS:
Ampullary
carcinoma
tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection.
RESULTS: Positive staining
of ampullary
carcinoma
cells was observed in 26 (68.4%) cases.
Staining was not found in the surrounding non-
cancer
regions of the
ampullary
tissues.
Remarkable KL-6 expression was observed in invasive
carcinoma
cells in
pancreatic
and duodenal tissues and in metastatic
carcinoma
cells in lymph nodes.
Positive KL-6 expression was related to lymph node metastasis (P = 0.020),
pancreatic
invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010).
CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of
carcinoma
of the
ampulla
of
Vater
.
[MeSH-major]
Ampulla
of
Vater
. Antigens / metabolism. Common Bile Duct Neoplasms / metabolism. Glycoproteins / metabolism. Mucins / metabolism
[MeSH-minor]
Aged. Aged, 80 and over. Antigens,
Neoplasm
. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin-1
Genetic Alliance.
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NCI CPTC Antibody Characterization Program.
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(PMID = 16222735.001).
[ISSN]
1007-9327
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
[Chemical-registry-number]
0 / Antigens; 0 / Antigens, Neoplasm; 0 / Glycoproteins; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Mucins
[Other-IDs]
NLM/ PMC4320352
41.
Bhangle SD, Kramer N, Rosenstein ED:
Spondyloarthropathy after ampullary carcinoma resection: "post-Whipple" disease.
J Clin Rheumatol
; 2009 Aug;15(5):241-3
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[Title]
Spondyloarthropathy after
ampullary
carcinoma
resection: "post-Whipple" disease.
The development of bowel-bypass syndrome complicating the Whipple procedure for biliary tract
carcinoma
is described here for the first time.
A 56-year-old HLA-B27 + man, treated with excision of adenocarcinoma of the
ampulla
of
Vater
, developed an undifferentiated spondyloarthropathy, initially unresponsive to nonsteroidal anti-inflammatory drugs and doxycycline, but eventually controlled with sulfasalazine and tapered corticosteroids.
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(PMID = 19590445.001).
[ISSN]
1536-7355
[Journal-full-title]
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
[ISO-abbreviation]
J Clin Rheumatol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Adrenal Cortex Hormones
42.
Yao HS, Wang Q, Wang WJ, Hu ZQ:
Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis.
World J Surg
; 2008 Sep;32(9):2038-46
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[Title]
Intraoperative allogeneic red blood cell transfusion in
ampullary
cancer
outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis.
BACKGROUND: Allogeneic blood transfusion (ABT) containing packed red blood cells (RBCs) has a known immunosuppressive effect that may affect
cancer
metastases and recurrence.
This study examined whether intraoperative allogeneic RBC transfusion is an independent risk factor of adverse outcome in patients with
ampullary
carcinoma
after curative pancreatoduodenectomy.
METHODS: The clinical data of 67 patients with
carcinoma
of the
ampulla
of Vatar underwent pancreatoduodenectomy between 1999 and 2004 were analyzed, and long-term follow-up visits were made for all patients.
For the meta-analysis, all English-language studies regarding blood transfusion from
carcinoma
of the
ampulla
of Vatar or
ampullary
carcinoma
and prognostic factors or factors for survival from 1995 to 2007 were reviewed, and contingency tables were constructed from which a summary relative risk was calculated.
After multivariate analysis, except for presence of lymph node metastasis (P = 0.023) and
pancreatic
invasion (P = 0.024), the intraoperative ABT > or =3 units was found to be an independent poor prognostic factor for those with
ampullary
cancer
after curative pancreatoduodenectomy either (relative risk, 2.082; 95% confidence interval (CI), 1.048-4.135; P = 0.036).
CONCLUSIONS: The amount of intraoperative ABT is one of the important factors that adversely influenced survival in patients with
ampullary
cancer
after curative pancreatoduodenectomy.
[MeSH-major]
Ampulla
of
Vater
/ surgery. Erythrocyte Transfusion.
Pancreatic
Neoplasms / surgery. Pancreaticoduodenectomy
[MeSH-minor]
Adult. Aged. Blood Loss, Surgical. Blood Transfusion, Autologous. Chi-Square Distribution. Female. Humans. Intraoperative Care. Male. Middle Aged.
Neoplasm
Staging. Prognosis. Proportional Hazards Models. Risk Factors. Survival Analysis. Treatment Outcome
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[ISSN]
0364-2313
[Journal-full-title]
World journal of surgery
[ISO-abbreviation]
World J Surg
[Language]
eng
[Publication-type]
Journal Article; Meta-Analysis
[Publication-country]
United States
43.
Aimoto T, Uchida E, Nakamura Y, Katsuno A, Chou K, Tajiri T, Naito Z:
Malignant afferent loop obstruction following pancreaticoduodenectomy: report of two cases.
J Nippon Med Sch
; 2006 Aug;73(4):226-30
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[Title]
Malignant
afferent loop obstruction following pancreaticoduodenectomy: report of two cases.
We report two cases
of malignant
afferent loop obstruction following pancreaticoduodenectomy (PD). Case 1.
A 70-year-old woman, who had undergone PD for
pancreatic
cancer
, was referred to our hospital because of fever, jaundice, and abdominal pain.
Laparotomy confirmed the
diagnosis of
local recurrent tumor causing occlusion of the afferent limb, and Roux-en-Y bypass was performed. Case 2.
A 72-year-old man, who had undergone PD for
cancer
of the major
papilla
, was hospitalized with a high-grade fever and epigastric pain.
[MeSH-minor]
Aged.
Ampulla
of
Vater
.
Carcinoma
/ complications. Common Bile Duct Neoplasms / complications. Female. Humans. Male.
Neoplasm
Recurrence, Local.
Pancreatic
Neoplasms / complications. Postoperative Complications
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(PMID = 16936449.001).
[ISSN]
1345-4676
[Journal-full-title]
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
[ISO-abbreviation]
J Nippon Med Sch
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
44.
Schirmacher P, Büchler MW:
Ampullary adenocarcinoma - differentiation matters.
BMC Cancer
; 2008;8:251
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[Title]
Ampullary
adenocarcinoma - differentiation matters.
This fuels the discussion about maintaining
ampullary
cancer
as a separate entity.
[MeSH-major]
Adenocarcinoma /
diagnosis
.
Ampulla
of
Vater
/ pathology. Common Bile Duct Neoplasms /
diagnosis
[MeSH-minor]
Biomarkers, Tumor. Cell Differentiation.
Diagnosis
, Differential. Epithelium / pathology. Humans. Medical Oncology / methods. Prognosis
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[ISSN]
1471-2407
[Journal-full-title]
BMC cancer
[ISO-abbreviation]
BMC Cancer
[Language]
eng
[Publication-type]
Editorial
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Other-IDs]
NLM/ PMC2553420
45.
Miyakawa S, Ishihara S, Takada T, Miyazaki M, Tsukada K, Nagino M, Kondo S, Furuse J, Saito H, Tsuyuguchi T, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology:
Flowcharts for the management of biliary tract and ampullary carcinomas.
J Hepatobiliary Pancreat Surg
; 2008;15(1):7-14
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[Title]
Flowcharts for the management of biliary tract and
ampullary
carcinomas.
No strategies for the
diagnosis
and treatment of biliary tract
carcinoma
have been clearly described.
We developed flowcharts for the
diagnosis
and treatment of biliary tract
carcinoma
on the basis of the best clinical evidence.
Risk factors for bile duct
carcinoma
are a dilated type of pancreaticobiliary maljunction (PBM) and primary sclerosing cholangitis.
A nondilated type of PBM is a risk factor for gallbladder
carcinoma
.
Symptoms that may indicate biliary tract
carcinoma
are jaundice and pain in the upper right area of the abdomen.
The first step
of diagnosis
is to carry out blood biochemistry tests and ultrasonography (US) of the abdomen.
The second step
of diagnosis
is to find the local extension of the
carcinoma
by means of computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance cholangiopancreatography (MRCP), percutaneous transhepatic cholangiography (PTC), and endoscopic retrograde cholangiopancreatography (ERCP).
Because resection is the only way to completely cure biliary tract
carcinoma
, the indications for resection are determined first.
[MeSH-major]
Algorithms.
Ampulla
of
Vater
. Biliary Tract Neoplasms.
Carcinoma
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(PMID = 18274839.001).
[ISSN]
0944-1166
[Journal-full-title]
Journal of hepato-biliary-pancreatic surgery
[ISO-abbreviation]
J Hepatobiliary Pancreat Surg
[Language]
eng
[Publication-type]
Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
[Publication-country]
Japan
[Other-IDs]
NLM/ PMC2794355
[Investigator]
Kai M; Kimura Y; Kai S; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Shikata S; Nimura Y
46.
Warnick P, Bahra M, Andreou A, Neuhaus P, Glanemann M:
[Second-look operation in pancreatic carcinoma previously assessed as unresectable].
Zentralbl Chir
; 2010 Feb;135(1):70-4
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[Title]
[Second-look operation in
pancreatic
carcinoma
previously assessed as unresectable].
BACKGROUND: The only curative therapy for patients with
pancreatic
carcinoma
consists of -complete surgical tumour removal.
PATIENTS AND METHODS: We report herein on 17 patients who were judged during exploratory laparotomy elsewhere to suffer from non-resectable
pancreatic
cancer
and who underwent a second-look operation after referral to our hospital.
The classic Kausch-Whipple operation was performed in 4, pylorus-preserving pancreaticoduodenectomy in 5, and left
pancreatic
-resection in another 4 patients.
Mean survival in patients after tumour resection was increased, reach-ing 17.6 months compared to 6.5 months in patients with non-resectable
pancreatic
cancer
.
Thus, complex visceral operations like
pancreatic
carcinoma
resection should preferably be performed in high-volume centres exclusively.
[MeSH-major]
Ampulla
of
Vater
/ surgery.
Carcinoma
,
Pancreatic
Ductal / surgery. Common Bile Duct Neoplasms / surgery.
Pancreatic
Neoplasms / surgery
[MeSH-minor]
Academic Medical Centers. Adult. Aged. Disease Progression. Female. Follow-Up Studies. Germany. Hospitals, General / statistics & numerical data. Humans. Magnetic Resonance Imaging. Male. Middle Aged.
Neoplasm
Invasiveness.
Neoplasm
Staging. Palliative Care. Pancreas / pathology. Pancreas / surgery. Prognosis. Referral and Consultation / statistics & numerical data. Reoperation / statistics & numerical data. Survival Rate. Tomography, X-Ray Computed
MedlinePlus Health Information.
consumer health - Pancreatic Cancer
.
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[Copyright]
Georg Thieme Verlag Stuttgart, New York.
(PMID = 20162503.001).
[ISSN]
1438-9592
[Journal-full-title]
Zentralblatt für Chirurgie
[ISO-abbreviation]
Zentralbl Chir
[Language]
ger
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Germany
47.
Kepron C, Kapila V, Hanna S, Khalifa MA:
Periampullary carcinoid of the ampulla of Vater presenting as an intraductal papillary mucinous tumour of the pancreas: a sheep in wolf's clothing.
Can J Surg
; 2008 Jun;51(3):E67-8
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[Title]
Periampullary carcinoid of the
ampulla
of
Vater
presenting as an intraductal papillary mucinous tumour of the pancreas: a sheep in wolf's clothing.
[MeSH-major]
Adenocarcinoma, Mucinous /
diagnosis
.
Ampulla
of
Vater
.
Carcinoma
,
Pancreatic
Ductal /
diagnosis
. Common Bile Duct Neoplasms /
diagnosis
[MeSH-minor]
Dilatation, Pathologic. Humans. Immunohistochemistry. Male. Middle Aged. Pancreatectomy.
Pancreatic
Ducts / pathology.
Pancreatic
Ducts / radiography. Tomography, X-Ray Computed
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[Cites]
J Gastrointest Surg. 2003 Sep-Oct;7(6):773-6
[
13129555.001
]
[Cites]
N Engl J Med. 1999 Mar 18;340(11):858-68
[
10080850.001
]
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]
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[
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]
[Cites]
Cancer. 1999 Mar 15;85(6):1241-9
[
10189128.001
]
(PMID = 18682788.001).
[ISSN]
1488-2310
[Journal-full-title]
Canadian journal of surgery. Journal canadien de chirurgie
[ISO-abbreviation]
Can J Surg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Canada
[Other-IDs]
NLM/ PMC2496582
48.
Genc H, Haciyanli M, Tavusbay C, Colakoglu O, Aksöz K, Unsal B, Ekinci N:
Carcinoma arising from villous adenoma of the ampullary bile duct: Report of a case.
Surg Today
; 2007;37(2):165-8
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[Title]
Carcinoma
arising from villous adenoma of the
ampullary
bile duct: Report of a case.
Adenocarcinoma arising from the villous adenoma of the
ampullary
biliary epithelium is an extremely rare
disorder
.
The preoperative
diagnosis
and treatment of the disease represent a major difficulty.
Next, a transduodenal resection of
ampulla
and reconstruction were performed.
This case shows the importance of surgeons to keep in mind the fact that frozen examinations may sometimes miss a malignancy and they therefore cannot be relied upon to rule out malignancy in villous adenoma of the
ampullary
bile duct.
[MeSH-major]
Adenocarcinoma /
diagnosis
. Adenoma, Villous /
diagnosis
.
Ampulla
of
Vater
. Common Bile Duct Neoplasms /
diagnosis
. Neoplasms, Multiple Primary
[MeSH-minor]
Aged. Cholangiopancreatography, Endoscopic Retrograde. Cholecystectomy.
Diagnosis
, Differential. Duodenoscopy. Female. Follow-Up Studies. Humans
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[Cites]
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11382317.001
]
(PMID = 17243040.001).
[ISSN]
0941-1291
[Journal-full-title]
Surgery today
[ISO-abbreviation]
Surg. Today
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
49.
Lehwald N, Cupisti K, Baldus SE, Kröpil P, Schulte Am Esch J 2nd, Eisenberger CF, Knoefel WT:
Unusual histological findings after partial pancreaticoduodenectomy including benign multicystic mesothelioma, adenomyoma of the ampulla of Vater, and undifferentiated carcinoma, sarcomatoid variant: a case series.
J Med Case Rep
; 2010;4:402
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[Title]
Unusual histological findings after partial pancreaticoduodenectomy including benign multicystic mesothelioma, adenomyoma of the
ampulla
of
Vater
, and undifferentiated
carcinoma
, sarcomatoid variant: a case series.
INTRODUCTION: The standard operation for
carcinoma
of the
pancreatic
head is a partial pancreaticoduodenectomy.
Histology showed an adenomyoma of the
ampulla
.
Pathology showed an undifferentiated
carcinoma
, sarcomatoid variant.
Adenomyoma of the bile duct or
ampullary
region is a very unusual, benign, localized lesion characterized by adenomyomatous hyperplasia.
Undifferentiated
carcinoma
, sarcomatoid variant, is an aggressive tumor and is characterized by spindle cells.
As the lesions were suspicious for
carcinoma
, partial pancreaticoduodenectomy was justified in all three patients.
The histologic
diagnosis
after partial pancreaticoduodenectomy may differ from the preoperative and intraoperative findings.
These cases demonstrate that a definitive
diagnosis
may only be obtained by a pathologic examination of the surgical specimen.
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(PMID = 21143956.001).
[ISSN]
1752-1947
[Journal-full-title]
Journal of medical case reports
[ISO-abbreviation]
J Med Case Rep
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC3016302
50.
Kobayashi A, Konishi M, Nakagohri T, Takahashi S, Kinoshita T:
Therapeutic approach to tumors of the ampulla of Vater.
Am J Surg
; 2006 Aug;192(2):161-4
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[Title]
Therapeutic approach to tumors of the
ampulla
of
Vater
.
BACKGROUND/AIM: Indications for local resection for tumors of the
ampulla
of
Vater
have not been established.
The present study evaluated suitable treatments for tumors of the
papilla of
Vater
.
PATIENTS AND METHODS: Clinicopathological factors were reviewed for 53 patients with tumors of the
ampulla
of
Vater
treated between February 1993 and August 2003.
Lymph node metastasis was identified in 20 patients who received radical resection, including 1 patient with pT1
cancer
.
CONCLUSION: Given the presence of some positive surgical margins, local resection is indicated as a therapeutic approach to tumors of the
papilla of
Vater
only for benign tumors or some
malignant
tumors that cannot undergo pancreaticoduodenectomy (PD).
[MeSH-major]
Adenoma / surgery.
Ampulla
of
Vater
.
Carcinoma
/ surgery. Common Bile Duct Neoplasms / surgery. Digestive System Surgical Procedures / methods
[MeSH-minor]
Adult. Aged. Biopsy. Cholangiopancreatography, Endoscopic Retrograde.
Diagnosis
, Differential. Endosonography. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome
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(PMID = 16860623.001).
[ISSN]
0002-9610
[Journal-full-title]
American journal of surgery
[ISO-abbreviation]
Am. J. Surg.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
51.
Abdullah SA, Gupta T, Jaafar KA, Chung YF, Ooi LL, Mesenas SJ:
Ampullary carcinoma: effect of preoperative biliary drainage on surgical outcome.
World J Gastroenterol
; 2009 Jun 21;15(23):2908-12
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[Title]
Ampullary
carcinoma
: effect of preoperative biliary drainage on surgical outcome.
AIM: To evaluate the influence of preoperative biliary drainage on morbidity and mortality after surgical resection for
ampullary
carcinoma
.
METHODS: We analyzed retrospectively data for 82 patients who underwent potentially curative surgery for
ampullary
carcinoma
between September 1993 and July 2007 at the Singapore General Hospital, a tertiary referral hospital.
Diagnosis of ampullary
carcinoma
was confirmed histologically.
The following parameters were analyzed: wound infection, intra-abdominal abscess, intra-abdominal or gastrointestinal bleeding, septicemia, biliary or
pancreatic
leakage, pancreatitis, gastroparesis, and re-operation rate.
However, the rest of the parameters did not differ significantly between the groups, i.e. sepsis [10 (28.6%) vs 14 (29.8%)], intra-abdominal bleeding [1 (2.9%) vs 5 (10.6%)], intra-abdominal abscess [1 (2.9%) vs 8 (17%)], gastrointestinal bleeding [3 (8.6%) vs 5 (10.6%)],
pancreatic
leakage [2 (5.7%) vs 3 (6.4%)], biliary leakage [2 (5.7%) vs 3 (6.4%)], pancreatitis [2 (5.7%) vs 2 (4.3%)], gastroparesis [6 (17.1%) vs 10 (21.3%)], need for blood transfusion [10 (28.6%) vs 17 (36.2%)] and re-operation rate [1 (2.9%) vs 5 (10.6%)].
CONCLUSION: Biliary drainage before surgery for
ampullary
cancer
significantly reduced postoperative wound infection.
[MeSH-major]
Ampulla
of
Vater
/ surgery. Common Bile Duct Neoplasms / surgery. Drainage.
Pancreatic
Neoplasms / surgery. Preoperative Care
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consumer health - Pancreatic Cancer
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(PMID = 19533815.001).
[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
China
[Other-IDs]
NLM/ PMC2699011
52.
Jin SG, Chen ZY, Yan LN, Zeng Y, Huang W, Xu N:
A rare case of periampullary carcinoma with ectopic ending of Vater's ampulla.
World J Gastroenterol
; 2009 Oct 7;15(37):4729-31
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[Title]
A rare case of periampullary
carcinoma
with ectopic ending of
Vater
's
ampulla
.
Magnetic resonance imaging and magnetic resonance cholangiopancreatography (MRCP) showed the ectopic hepatopancreatic
ampulla
draining into the fourth part of the duodenum adjacent to the duodenojejunal flexure; the irregular morphology of the duodenojejunal flexure likely due to a soft tissue mass.
Laparotomy confirmed the presence of the abnormal
ampulla
of
Vater
located at the fourth part of the duodenum and a soft tissue tumor about 6 cm x 5 cm x 5 cm with a peduncle adjoining the
ampulla
.
Periampullary
carcinoma
with ectopic ending of the
Vater
's
ampulla
into the fourth part of the duodenum is rather rare.
It is worth mentioning that MRCP is useful for demonstrating anomalies and anatomic variants of the biliary tract system and
pancreatic
duct.
[MeSH-major]
Adenoma, Villous /
diagnosis
.
Ampulla
of
Vater
/ abnormalities. Duodenal Neoplasms /
diagnosis
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[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
China
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Other-IDs]
NLM/ PMC2754523
53.
Nguyen N, Shah JN, Binmoeller KF:
Outcomes of endoscopic papillectomy in elderly patients with ampullary adenoma or early carcinoma.
Endoscopy
; 2010 Nov;42(11):975-7
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[Title]
Outcomes of endoscopic papillectomy in elderly patients with
ampullary
adenoma or early
carcinoma
.
Outcomes for 14 elderly (age ≥ 70 years) patients (79.4 ± 1.0 years) who underwent endoscopic papillectomy for
ampullary
tumors were compared with those of 22 younger (age < 70 years) patients (52.5 ± 1.9 years).
Whilst all younger patients survived, five elderly patients died but three of these deaths were not
cancer
-related.
Advanced age, therefore, did not adversely influence the outcomes of endoscopic papillectomy, suggesting it may be a treatment of choice for elderly patients with
ampullary
tumors or early
cancer
who are deemed unfit for surgery.
[MeSH-major]
Adenoma, Acidophil / surgery.
Ampulla
of
Vater
/ surgery.
Carcinoma
/ surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Gastrointestinal
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[Copyright]
© Georg Thieme Verlag KG Stuttgart · New York.
(PMID = 21072717.001).
[ISSN]
1438-8812
[Journal-full-title]
Endoscopy
[ISO-abbreviation]
Endoscopy
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
Germany
54.
Shan Y, Zhao DB, Che X, Wang JX, Shao YF, Zhao P:
[Clinical significance of solitary lymph node metastasis in carcinoma of the ampulla of Vater].
Zhonghua Zhong Liu Za Zhi
; 2006 Sep;28(9):694-6
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[Title]
[Clinical significance of solitary lymph node metastasis in
carcinoma
of the
ampulla
of
Vater
].
OBJECTIVE: To investigate the rule of distribution of solitary lymph node metastasis and its relation with clinico-pathologic factors in
carcinoma
of
ampulla
of
Vater
.
METHODS: The data of 26 patients who were discovered to have solitary lymph node metastasis, from 152 patients with
carcinoma
of the
ampulla
of
Vater
who had received pancreatoduodenectomy were retrospectively reviewed.
RESULTS: Of these 152 patients with
carcinoma
of
ampulla
of
Vater
, 47(30.
000) and
pancreatic
infiltration (P =0. 009).
Sentinel lymph node assessment may be helpful to determine the extent of lymph node dissection for
carcinoma
of the
ampulla
of
Vater
.
[MeSH-major]
Adenocarcinoma / pathology.
Ampulla
of
Vater
. Common Bile Duct Neoplasms / pathology
[MeSH-minor]
Adult. Aged. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged.
Neoplasm
Invasiveness.
Neoplasm
Staging.
Pancreatic
Neoplasms / pathology. Pancreaticoduodenectomy. Retrospective Studies. Sentinel Lymph Node Biopsy
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(PMID = 17274378.001).
[ISSN]
0253-3766
[Journal-full-title]
Zhonghua zhong liu za zhi [Chinese journal of oncology]
[ISO-abbreviation]
Zhonghua Zhong Liu Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
55.
Roa JC, Anabalón L, Tapia O, Melo A, de Aretxabala X, Roa I:
[Frequency of K-ras mutation in biliary and pancreatic tumors].
Rev Med Chil
; 2005 Dec;133(12):1434-40
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[Title]
[Frequency of K-ras mutation in biliary and
pancreatic
tumors].
BACKGROUND: The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human
cancer
, specially in tumors of the biliary tract and pancreas.
AIM: To determine the frequency of K-ras gene codon 12 mutation in
pancreatic
and biliary tumors.
MATERIAL AND METHODS: Samples of 35 gallbladder, 15
ampulla
of
Vater
, 10 biliary tract and 9
pancreatic
tumors, were analyzed.
Mutation frequency was 80, 56, 50 and 29% for
ampulla
of
Vater
,
pancreatic
, biliary tract and gallbladder tumors, respectively.
CONCLUSIONS: Gallbladder
carcinoma
had the lower frequency of K-ras mutation, when compared with
pancreatic
, biliary tract and
ampulla
of
Vater
tumors.
[MeSH-major]
Carcinoma
/ genetics. Gallbladder Neoplasms / genetics. Genes, ras / genetics. Mutation.
Pancreatic
Neoplasms / genetics
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(PMID = 16446870.001).
[ISSN]
0034-9887
[Journal-full-title]
Revista médica de Chile
[ISO-abbreviation]
Rev Med Chil
[Language]
spa
[Publication-type]
Comparative Study; English Abstract; Journal Article
[Publication-country]
Chile
[Chemical-registry-number]
0 / Codon
56.
Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM:
Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Am J Surg Pathol
; 2005 Mar;29(3):359-67
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[Title]
Immunohistochemical staining in the
diagnosis of
pancreatobiliary and
ampulla
of
Vater
adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
Pancreatobiliary and
ampulla
of
Vater
adenocarcinomas frequently metastasize to regional lymph nodes, liver, or lung and are difficult to diagnose because they lack specific immunohistochemical markers.
We studied the expression of cytokeratin 7 (CK7), cytokeratin 17 (CK17), cytokeratin 20 (CK20), CDX2, mucin 1 (MUC1), mucin 2 (MUC2), and mucin 5AC (MUC5AC) in 46 cases
of pancreatic
ductal
carcinoma
, 18
ampulla
of
Vater
adenocarcinomas, and 24 intrahepatic cholangiocarcinomas.
The expression of MUC1 and CK17 was restricted to
pancreatic
ductal
carcinoma
(41 of 46, 89%; 38 of 46, 83%, respectively), the
ampullary
carcinoma
of pancreatobiliary origin (6 of 6, 100%; 5 of 6, 83%, respectively), and intrahepatic cholangiocarcinoma (20 of 24, 83%; 17 of 24, 71%, respectively).
MUC2 was rarely expressed in
pancreatic
ductal
carcinoma
(1 of 46, 2%) and was negative in the
ampullary
carcinoma
of pancreatobiliary origin and in intrahepatic cholangiocarcinoma.
A heterogeneous CDX2 staining pattern was seen in 1 of 6 cases of the
ampullary
carcinoma
of pancreatobiliary origin (17%), 5 of 24 intrahepatic cholangiocarcinomas (21%), and 10 of 46 (22%)
pancreatic
ductal carcinomas.
We concluded that CK17 is a useful marker in separating pancreatobiliary adenocarcinomas from extra-pancreatobiliary nonmucinous adenocarcinomas, including adenocarcinomas from the colon, breast, gynecologic organs, stomach, lung, prostate, thyroid, kidney, and adrenal gland, and
malignant
mesothelioma.
MUC1+/CK17+ can be used as positive markers for
pancreatic
ductal carcinomas, the
ampullary
carcinoma
of pancreatobiliary origin, and cholangiocarcinomas with positive predictive values of 76%, 83%, and 58%, respectively.
[MeSH-major]
Ampulla
of
Vater
/ pathology. Bile Ducts, Intrahepatic / pathology.
Carcinoma
,
Pancreatic
Ductal / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology.
Pancreatic
Neoplasms / pathology
[MeSH-minor]
Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism.
Neoplasm
Proteins / metabolism
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(PMID = 15725805.001).
[ISSN]
0147-5185
[Journal-full-title]
The American journal of surgical pathology
[ISO-abbreviation]
Am. J. Surg. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
57.
Palanivelu C, Jategaonkar PA, Rangarajan M, Anand NV, Senthilnathan P:
Laparoscopic management of a retroperitoneal duodenal perforation following ERCP for periampullary cancer.
JSLS
; 2008 Oct-Dec;12(4):399-402
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[Title]
Laparoscopic management of a retroperitoneal duodenal perforation following ERCP for periampullary
cancer
.
CASE REPORT: The patient is a 60-year-old female who underwent ERCP for obstructive jaundice due to periampullary
carcinoma
, during which the perforation occurred.
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[Cites]
Endoscopy. 2002 Dec;34(12):991-7
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12471544.001
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[
12709688.001
]
(PMID = 19275857.001).
[ISSN]
1086-8089
[Journal-full-title]
JSLS : Journal of the Society of Laparoendoscopic Surgeons
[ISO-abbreviation]
JSLS
[Language]
ENG
[Publication-type]
Case Reports; Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC3015994
58.
Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, Roughton M, Bridgewater J, ABC-02 Trial Investigators:
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
N Engl J Med
; 2010 Apr 8;362(14):1273-81
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[Title]
Cisplatin plus gemcitabine versus gemcitabine for biliary tract
cancer
.
BACKGROUND: There is no established standard chemotherapy for patients with locally advanced or metastatic biliary tract
cancer
.
METHODS: We randomly assigned 410 patients with locally advanced or metastatic cholangiocarcinoma, gallbladder
cancer
, or
ampullary
cancer
to receive either cisplatin (25 mg per square meter of body-surface area) followed by gemcitabine (1000 mg per square meter on days 1 and 8, every 3 weeks for eight cycles) or gemcitabine alone (1000 mg per square meter on days 1, 8, and 15, every 4 weeks for six cycles) for up to 24 weeks.
Cisplatin plus gemcitabine is an appropriate option for the treatment of patients with advanced biliary
cancer
. (ClinicalTrials.gov number, NCT00262769. )
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[Copyright]
2010 Massachusetts Medical Society
[CommentIn]
Z Gastroenterol. 2010 Aug;48(8):850-1
[
20687022.001
]
[CommentIn]
N Engl J Med. 2010 Apr 8;362(14):1335-7
[
20375411.001
]
[CommentIn]
J Hepatol. 2011 Mar;54(3):577-8
[
21112109.001
]
[CommentIn]
N Engl J Med. 2010 Jul 8;363(2):192; author reply 192-3
[
20653076.001
]
[CommentIn]
N Engl J Med. 2010 Jul 8;363(2):192; author reply 192-3
[
20647216.001
]
[CommentIn]
Expert Rev Gastroenterol Hepatol. 2010 Aug;4(4):395-7
[
20678012.001
]
(PMID = 20375404.001).
[ISSN]
1533-4406
[Journal-full-title]
The New England journal of medicine
[ISO-abbreviation]
N. Engl. J. Med.
[Language]
eng
[Databank-accession-numbers]
ClinicalTrials.gov/ NCT00262769
[Grant]
United Kingdom / Cancer Research UK / /
[Publication-type]
Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
[Investigator]
Nicholson M; Corrie P; Eatock M; Falk S; Elyan S; Valle J; Anthony A; Nicoll J; Kulkarni R; Osbourne R; Garcia Alonso A; Wasan H; Waters J; Harrison M; Adamson D; Rees C; Bridgewater J; Madhusudan S; McAdam K; Bridgewater J; Maraveyas A; Palmer D; Hickish T; Meyer T; Cunningham D; Iveson T; Middleton G; Slater S; Lofts F; Archer C; Iveson T; Iveson T; Bridgewater J; Mukherjee S; Wadsley J; Gollins S
59.
Bel Hadj N, Elloumi H, Babba T, Kchaou-Oukaa A, Gargouri D, Kochlef A, Romani M, Kilani A, Kharrat J, Ghorbel A:
[Carcinoma of the papilla of Vater. Diagnostic and therapeutic problems. An analysis of 32 Tunisian cases].
Tunis Med
; 2006 Nov;84(11):701-4
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[Title]
[
Carcinoma
of the
papilla of
Vater
. Diagnostic and therapeutic problems. An analysis of 32 Tunisian cases].
[Transliterated title]
Carcinome de l'ampoule de
Vater
: problémes diagnostiques et therapeutiques. Analyse d'une série
de
32 patients.
The aim determine the clinical, morphological, endoscopical and progressive profile of patients with
ampullary
carcinoma
.
PATIENTS AND METHODS: Thirty-two patients with a
carcinoma
of the
ampulla
of
Vater
, hospitalised in the Gastro-enterology service of Habib Thameur Hospital (Tunis) (1992-2002) have been analysed retrospectively.
Twelve patients (37%) had had a cholecystectomy into the 3 years preceding the
diagnosis of
the
ampullary
carcinoma
.
After endoscopical sphincterectomy, an intra-ampullar exophytic tumour had been found in I case and an infiltrated aspect of the
ampulla
of
Vater
in 2 cases.
The use of lateral duodenoscopy allowed carrying the positive
diagnosis
in all cases.
Five patients had metastasis at the moment
of diagnosis
.
CONCLUSION: The
ampullary
carcinoma
is a rare tumour diagnosed belated.
[MeSH-major]
Ampulla
of
Vater
.
Carcinoma
/
diagnosis
.
Carcinoma
/ therapy. Common Bile Duct Neoplasms /
diagnosis
. Common Bile Duct Neoplasms / therapy
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(PMID = 17294894.001).
[ISSN]
0041-4131
[Journal-full-title]
La Tunisie médicale
[ISO-abbreviation]
Tunis Med
[Language]
fre
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Tunisia
60.
DeOliveira ML, Triviño T, de Jesus Lopes Filho G:
Carcinoma of the papilla of Vater: are endoscopic appearance and endoscopic biopsy discordant?
J Gastrointest Surg
; 2006 Sep-Oct;10(8):1140-3
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[Title]
Carcinoma
of the
papilla of
Vater
: are endoscopic appearance and endoscopic biopsy discordant?
Carcinoma
of the
papilla of
Vater
is classified as periampullary
cancer
representing 5% of all gastrointestinal tract malignancies.
Early and accurate
diagnosis
is important for those patients with a tumor of the
papilla
, as the prognosis is more favorable than in other periampullary neoplasms.
Thirty patients with suspicion of
carcinoma
of the
papilla of
Vater
and with final
diagnosis
established by pancreatoduodenectomy were included in this retrospective study.
Although preoperative
diagnosis of
carcinoma
of the
papilla of
Vater
is useful for making therapeutic decisions, the diagnostic value of the endoscopic appearance was superior to endoscopic biopsy in this series.
[MeSH-major]
Ampulla
of
Vater
/ pathology. Common Bile Duct Neoplasms / pathology. Duodenoscopy
[MeSH-minor]
Biopsy / methods.
Diagnosis
, Differential. Humans. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity. Severity of Illness Index
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[ISSN]
1091-255X
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
61.
Watanabe M, Midorikawa Y, Yamano T, Mushiake H, Fukuda N, Kirita T, Mizuguchi K, Sugiyama Y:
Carcinoma of the papilla of Vater following treatment of pancreaticobiliary maljunction.
World J Gastroenterol
; 2009 Dec 28;15(48):6126-8
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[Title]
Carcinoma
of the
papilla of
Vater
following treatment of pancreaticobiliary maljunction.
Pancreaticobiliary maljunction (PBM) is frequently associated with biliary
cancer
due to reflux
of pancreatic
enzymes into the choledochus, and even after surgery to correct the PBM such patients still have a risk of residual bile duct
cancer
.
Here, we report the case of a 59-year-old female with
carcinoma
of the
papilla of
Vater
which developed 2.5 years after choledochoduodenostomy for PBM.
As a result,
carcinoma
of the
papilla of
Vater
was diagnosed at an early stage, followed by surgical cure.
For early detection of periampullary
cancer
in patients undergoing surgery for PBM, careful long-term follow-up is needed.
[MeSH-major]
Adenocarcinoma / etiology.
Ampulla
of
Vater
/ pathology. Bile Ducts, Extrahepatic / abnormalities. Common Bile Duct Neoplasms / etiology.
Pancreatic
Ducts / abnormalities. Postoperative Complications / etiology
MedlinePlus Health Information.
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[Cites]
Surgery. 1999 Nov;126(5):939-44
[
10568195.001
]
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14598134.001
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17171495.001
]
[Cites]
J Hepatobiliary Pancreat Surg. 1998;5(1):113-6
[
9683764.001
]
(PMID = 20027689.001).
[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
[Other-IDs]
NLM/ PMC2797673
62.
Santini D, Baldi A, Vincenzi B, Mellone P, Campioni M, Antinori A, Borzomati D, Coppola R, Magistrelli P, Tonini G:
Mucin 2 (MUC2) and mucin 5 (MUC5) expression is not associated with prognosis in patients with radically resected ampullary carcinoma.
J Clin Pathol
; 2007 Sep;60(9):1069-70
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[Title]
Mucin 2 (MUC2) and mucin 5 (MUC5) expression is not associated with prognosis in patients with radically resected
ampullary
carcinoma
.
[MeSH-major]
Ampulla
of
Vater
. Biomarkers, Tumor / metabolism. Common Bile Duct Neoplasms / metabolism. Mucins / metabolism
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Mucin-2. Mucin-5B.
Neoplasm
Proteins / metabolism. Prognosis. Survival Analysis
NCI CPTAC Assay Portal.
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.
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[Cites]
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[
16191504.001
]
(PMID = 17761747.001).
[ISSN]
0021-9746
[Journal-full-title]
Journal of clinical pathology
[ISO-abbreviation]
J. Clin. Pathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / MUC5B protein, human; 0 / Mucin-2; 0 / Mucin-5B; 0 / Mucins; 0 / Neoplasm Proteins
[Other-IDs]
NLM/ PMC1972431
63.
Ishii Y, Takahashi M, Yoshida S, Suzuki K:
[A case of hepatic metastases of ampullary carcinoma which completely responded to intrahepatic infusion of 5-FU with low-dose l-leucovorin].
Gan To Kagaku Ryoho
; 2005 Aug;32(8):1175-7
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[Title]
[A case of hepatic metastases
of ampullary
carcinoma
which completely responded to intrahepatic infusion of 5-FU with low-dose l-leucovorin].
A 70-year-old man was admitted with an
ampullary
carcinoma
with multiple hepatic metastases.
[MeSH-major]
Ampulla
of
Vater
. Duodenal Neoplasms / pathology. Fluorouracil / administration & dosage. Leucovorin / administration & dosage. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary
MedlinePlus Health Information.
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.
Hazardous Substances Data Bank.
FLUOROURACIL
.
Hazardous Substances Data Bank.
LEUCOVORIN
.
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(PMID = 16121924.001).
[ISSN]
0385-0684
[Journal-full-title]
Gan to kagaku ryoho. Cancer & chemotherapy
[ISO-abbreviation]
Gan To Kagaku Ryoho
[Language]
jpn
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
64.
Chiche L, Alkofer B, Parienti JJ, Rouleau V, Salamé E, Samama G, Segol P:
Usefulness of follow-up after pancreatoduodenectomy for carcinoma of the ampulla of Vater.
HPB (Oxford)
; 2007;9(2):140-5
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[Title]
Usefulness of follow-up after pancreatoduodenectomy for
carcinoma
of the
ampulla
of
Vater
.
BACKGROUND: The prognosis for
carcinoma
of the
ampulla
of
Vater
(CAV) is better than for
pancreatic
cancer
.
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[Cites]
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[Cites]
J Korean Med Sci. 1999 Apr;14(2):220-2
[
10331573.001
]
(PMID = 18333130.001).
[ISSN]
1365-182X
[Journal-full-title]
HPB : the official journal of the International Hepato Pancreato Biliary Association
[ISO-abbreviation]
HPB (Oxford)
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2020781
65.
Imazu H, Uchiyama Y, Matsunaga K, Ikeda K, Kakutani H, Sasaki Y, Sumiyama K, Ang TL, Omar S, Tajiri H:
Contrast-enhanced harmonic EUS with novel ultrasonographic contrast (Sonazoid) in the preoperative T-staging for pancreaticobiliary malignancies.
Scand J Gastroenterol
; 2010 Jun;45(6):732-8
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The final
diagnosis
were
pancreatic
cancer
in 11, bile duct
cancer
in 7, gallbladder
cancer
in 4 and
ampullary
cancer
in 4.
CH-EUS staged correctly in all of these six cases, whereas H-EUS misdiagnosed the depth of invasion in one case of gallbladder
cancer
and one case
of ampullary
cancer
, and invasion of portal vein in two cases
of pancreatic
cancer
and two cases of bile duct
cancer
.
CONCLUSION: The depth of invasion of biliary
cancer
and vascular invasion
of pancreatic
and biliary
cancer
could be demonstrated more clearly with CH-EUS compared to H-EUS.
[MeSH-major]
Biliary Tract Neoplasms / ultrasonography. Contrast Media / administration & dosage. Endosonography / methods. Ferric Compounds. Iron.
Neoplasm
Staging / methods. Oxides.
Pancreatic
Neoplasms / ultrasonography
[MeSH-minor]
Diagnosis
, Differential. Follow-Up Studies. Humans. Injections, Intravenous. Pilot Projects. Preoperative Period. Prospective Studies. Reproducibility of Results
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.
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(PMID = 20205504.001).
[ISSN]
1502-7708
[Journal-full-title]
Scandinavian journal of gastroenterology
[ISO-abbreviation]
Scand. J. Gastroenterol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
England
[Chemical-registry-number]
0 / Contrast Media; 0 / Ferric Compounds; 0 / Oxides; 0 / Sonazoid; E1UOL152H7 / Iron
66.
Komatsu S, Sonoyama T, Ochiai T, Ichikawa D, Ikoma H, Okamura H, Otsuji E:
Long-term complete response of multiple hepatic metastases from carcinoma of the papilla of Vater using intrahepatic infusion of 5-FU with low-dose cisplatin following pancreaticoduodenectomy.
Int J Clin Oncol
; 2008 Dec;13(6):567-70
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[Title]
Long-term complete response of multiple hepatic metastases from
carcinoma
of the
papilla of
Vater
using intrahepatic infusion of 5-FU with low-dose cisplatin following pancreaticoduodenectomy.
Of all distant metastases from
carcinoma
of the
papilla of
Vater
(CPV), the liver is the most frequent site (more than 60%) and should be specifically targeted in the effort to improve the prognosis.
[MeSH-major]
Ampulla
of
Vater
/ pathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Liver Neoplasms / drug therapy. Pancreaticoduodenectomy
MedlinePlus Health Information.
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.
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[Cites]
Ann Surg. 1998 Jul;228(1):87-94
[
9671071.001
]
[Cites]
Ann Oncol. 1998 Jun;9(6):653-6
[
9681080.001
]
[Cites]
Ann Surg Oncol. 2003 Dec;10(10):1176-83
[
14654474.001
]
[Cites]
J Clin Oncol. 1984 May;2(5):498-504
[
6547166.001
]
[Cites]
Cancer. 1996 Oct 15;78(8):1639-45
[
8859174.001
]
[Cites]
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[
9635523.001
]
[Cites]
Am J Pathol. 1954 Sep-Oct;30(5):969-77
[
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]
[Cites]
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[
10615075.001
]
[Cites]
Gan To Kagaku Ryoho. 2005 Aug;32(8):1175-7
[
16121924.001
]
[Cites]
Eur J Cancer. 1995 Sep;31A(10):1594-8
[
7488407.001
]
(PMID = 19093189.001).
[ISSN]
1341-9625
[Journal-full-title]
International journal of clinical oncology
[ISO-abbreviation]
Int. J. Clin. Oncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
67.
Wasan SM, Ross WA, Staerkel GA, Lee JH:
Use of expandable metallic biliary stents in resectable pancreatic cancer.
Am J Gastroenterol
; 2005 Sep;100(9):2056-61
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[Title]
Use of expandable metallic biliary stents in resectable
pancreatic
cancer
.
AIM: To compare the efficacy of metal versus plastic stents for biliary strictures in patients with surgically resectable
pancreatic
cancer
.
Of the 12 patients with pancreaticoduodenectomy, 10 had
pancreatic
adenocarcinoma, 1 intraductal papillary mucinous tumor, and 1
ampullary
cancer
.
Of the 35 patients, 27 had
pancreatic
adenocarcinoma, 5
ampullary
cancer
, 1 neuroendocrine tumor, 1 microcystic adenoma, and 1 autoimmune pancreatitis.
CONCLUSIONS: Contrary to the belief that metal stents are contraindicated for patients with surgically resectable
pancreatic
cancer
, our study demonstrated that metal stents provided a longer patency rate, fewer ERCP sessions, and fewer episodes of cholangitis without adding any intra- or postoperative complications.
Therefore, metal stents should be considered for patients with resectable
pancreatic
cancer
, especially if surgery is not immediately planned as more patients are now receiving preoperative chemoradiation.
[MeSH-major]
Pancreatic
Neoplasms / surgery.
Pancreatic
Neoplasms / therapy. Stents
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(PMID = 16128952.001).
[ISSN]
0002-9270
[Journal-full-title]
The American journal of gastroenterology
[ISO-abbreviation]
Am. J. Gastroenterol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Metals; 0 / Plastics
68.
Gandini R, Fabiano S, Pipitone V, Spinelli A, Reale CA, Colangelo V, Pampana E, Romagnoli A, Simonetti G:
Management of biliary neoplastic obstruction with two different metallic stents implanted in one session.
Cardiovasc Intervent Radiol
; 2005 Jan-Feb;28(1):48-52
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The efficacy of the "one-step" technique using two different metallic stents (Wallstent and Ultraflex) and associated rate of complications was studied in 87 patients with jaundice secondary to
malignant
biliary obstruction, with bilirubin level less than 15 mg/dl and Bismuth type 1 or 2 strictures.
The cause of the obstruction was
pancreatic
carcinoma
in 38 patients (44%), lymph node metastasis in 20 patients (23%), gallbladder
carcinoma
in 13 patients (15%), cholangiocarcinoma in 12 patients (14%) and
ampullary
carcinoma
in four patients (5%).
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(PMID = 15772722.001).
[ISSN]
0174-1551
[Journal-full-title]
Cardiovascular and interventional radiology
[ISO-abbreviation]
Cardiovasc Intervent Radiol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
69.
Kala Z, Weber P, Hemmelová B, Marek F, Hlavsa J, Sobotka M:
Ampullary tumours (ampullomas) in the elderly--an interdisciplinary problem.
Indian J Med Res
; 2010 Mar;131:418-21
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[Title]
Ampullary
tumours (ampullomas) in the elderly--an interdisciplinary problem.
BACKGROUND & OBJECTIVES:
Ampullary
cancer
is one of the periampullary tumours with better prognosis, but relapses occur early in some patients.
METHODS: Between 2005 and 2007, 19 patients (12 male, 7 female) aged over 65 yr (range 66 and 83 yr) with
diagnosis of
ampulloma were operated.
RESULTS: Of the 19 patients, 6 underwent local surgical ampullectomy with reinsertion of ductus choledochus and Wirsungi's duct for benign or early
cancer
lesion and 13 underwent PDE (Whipple operation).
INTERPRETATION & CONCLUSIONS:
Diagnosis
and therapy
of ampullary
tumours is multimodal.
[MeSH-major]
Ampulla
of
Vater
/ pathology.
Ampulla
of
Vater
/ surgery. Common Bile Duct Diseases /
diagnosis
. Common Bile Duct Diseases / therapy. Common Bile Duct Neoplasms / surgery
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(PMID = 20418556.001).
[ISSN]
0971-5916
[Journal-full-title]
The Indian journal of medical research
[ISO-abbreviation]
Indian J. Med. Res.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
India
70.
Qiao QL, Zhao YG, Ye ML, Yang YM, Zhao JX, Huang YT, Wan YL:
Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection.
World J Surg
; 2007 Jan;31(1):137-43; discussion 144-6
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[Title]
Carcinoma
of the
ampulla
of
Vater
: factors influencing long-term survival of 127 patients with resection.
INTRODUCTION: The prognosis for patients with
carcinoma
of the
ampulla
of
Vater
is improved relative to other periampullary neoplasms.
Identification of independent prognostic factors in
ampullary
carcinomas has been limited by the small number of tumors resected.
The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected
ampullary
carcinoma
.
METHODS: Clinicopathologic data were retrospectively reviewed for patients with
ampullary
carcinomas radically resected between March 1987 and September 2002.
Ampullary
carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).
CONCLUSIONS:
Carcinoma
of the
ampulla
of
Vater
has a higher resectability rate and a much better survival rate than
pancreatic
cancer
.
[MeSH-major]
Adenocarcinoma / mortality. Adenocarcinoma / surgery.
Ampulla
of
Vater
. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
[MeSH-minor]
Adolescent. Adult. Aged. Female. Hospital Mortality. Humans. Lymphatic Metastasis. Male. Middle Aged.
Neoplasm
Invasiveness. Proportional Hazards Models. Retrospective Studies. Survival Analysis
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[ISSN]
0364-2313
[Journal-full-title]
World journal of surgery
[ISO-abbreviation]
World J Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
71.
Kolb A, Kleeff J, Friess H, Büchler MW:
[The effect of R1 resection in the hepatobiliary pancreatic system].
Chirurg
; 2007 Sep;78(9):802-9
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[Title]
[The effect of R1 resection in the hepatobiliary
pancreatic
system].
In most cases, however, R1 resections are determined by the anatomic location of the tumor and the growth pattern (e.g.
pancreatic
cancer
with perineural invasion).
[MeSH-major]
Ampulla
of
Vater
. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic.
Carcinoma
, Hepatocellular / surgery. Cholangiocarcinoma / surgery. Common Bile Duct Neoplasms / surgery. Gallbladder Neoplasms / surgery. Hepatic Duct, Common. Liver Neoplasms / surgery.
Neoplasm
, Residual / surgery.
Pancreatic
Neoplasms / surgery
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[Cites]
Dig Surg. 2006;23(1-2):103-9
[
16763375.001
]
[Cites]
Langenbecks Arch Chir. 1987;371(1):1-2
[
3626708.001
]
(PMID = 17680231.001).
[ISSN]
0009-4722
[Journal-full-title]
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
[ISO-abbreviation]
Chirurg
[Language]
ger
[Publication-type]
Comparative Study; English Abstract; Journal Article; Review
[Publication-country]
Germany
[Number-of-references]
61
72.
Khayyata S, Basturk O, Adsay NV:
Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils.
Mod Pathol
; 2005 Nov;18(11):1504-11
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Invasive micropapillary
carcinoma
, originally described as a distinctive type of invasive
carcinoma
in the breast, is being increasingly recognized as a separate entity in many other organs; however, it has not yet been documented in the pancreas or periampullary region.
In this study, 313
pancreatic
and 73 periampullary carcinomas were reviewed to investigate the micropapillary pattern in this location.
Eight periampullary and eight
pancreatic
cases (4%) were composed at least focally (>20%) of invasive micropapillary
carcinoma
.
Invasive micropapillary
carcinoma
was characterized by small, closely packed micropapillary clusters (without fibrovascular cores) lying within clefts.
In conclusion, invasive micropapillary
carcinoma
constitutes 4% of carcinomas in the
pancreatic
/periampullary region and is commonly associated with abundant neutrophilic infiltrates.
Invasive miropapillary
carcinoma
appears to be more common in periampullary than in
pancreatic
invasive micropapillary
carcinoma
would qualify as poorly differentiated both based on pattern and the median survival (8 months)..
[MeSH-major]
Ampulla
of
Vater
/ pathology.
Carcinoma
, Papillary / pathology. Common Bile Duct Neoplasms / pathology. Neutrophils / immunology.
Pancreatic
Neoplasms / pathology
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Antigens / metabolism. Antigens,
Neoplasm
. Cadherins / metabolism. Female. Galectin 3 / metabolism. Glycoproteins / metabolism. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged. Mucin-1. Mucins / metabolism. Retrospective Studies. Survival Rate
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[Copyright]
Modern Pathology (2005) 18, 1504-1511. doi:10.1038/modpathol.3800460; published online 8 July 2005.
(PMID = 16007065.001).
[ISSN]
0893-3952
[Journal-full-title]
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
[ISO-abbreviation]
Mod. Pathol.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antigens; 0 / Antigens, Neoplasm; 0 / Cadherins; 0 / Galectin 3; 0 / Glycoproteins; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Mucins
73.
Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y:
Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case.
Surg Today
; 2008;38(5):440-4
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[Title]
Recurrent pancreatitis caused by
ampullary
carcinoma
and minor
papilla
adenoma in familial polyposis: report of a case.
A 58-year-old man who had undergone total colectomy for FAP 18 years earlier was hospitalized for
carcinoma
arising from the residual rectum.
He had severe diabetes mellitus, but had no symptoms
of pancreatic
exocrine dysfunction.
Upper endoscopy showed multiple duodenal adenomas including
carcinoma
involving the
papilla of
Vater
.
To remove these duodenal adenomas and
ampullary
carcinoma
and prevent recurrent pancreatitis, we performed pancreaticoduodenectomy.
On pathologic examination, the major duodenal
papilla
was completely obstructed by the
carcinoma
, and the minor
papilla
was also involved by the adenoma.
[MeSH-major]
Adenocarcinoma / etiology. Adenoma / etiology. Adenomatous Polyposis Coli / complications.
Ampulla
of
Vater
. Common Bile Duct Neoplasms / etiology.
Pancreatic
Neoplasms / etiology. Pancreatitis / etiology
[MeSH-minor]
Humans. Male. Middle Aged.
Pancreatic
Ducts. Pancreaticoduodenectomy. Recurrence
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0941-1291
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Surgery today
[ISO-abbreviation]
Surg. Today
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
74.
Franko J, Krasinskas AM, Nikiforova MN, Zarnescu NO, Lee KK, Hughes SJ, Bartlett DL, Zeh HJ 3rd, Moser AJ:
Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.
J Gastrointest Surg
; 2008 Oct;12(10):1664-72; discussion 1672-3
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[Title]
Loss of heterozygosity predicts poor survival after resection
of pancreatic
adenocarcinoma.
BACKGROUND: American Joint Committee on
Cancer
(AJCC) staging for
pancreatic
adenocarcinoma is a validated predictor of prognosis but insufficiently discriminates postresection survival.
METHODS: Resected
pancreatic
ductal and
ampullary
adenocarcinomas (n = 50) were analyzed for loss of heterozygosity (LOH) at 15 markers including 5q(APC), 6q(TBSP2), 9p(p16), 10q(PTEN), 12q(MDM2), 17p(TP53), and 18q(DCC/SMAD4).
CONCLUSION: LOH and KRAS mutations indicate aggressive tumor biology and correlate strongly with survival in resected
pancreatic
ductal and
ampullary
carcinomas.
[MeSH-major]
Adenocarcinoma / genetics.
Ampulla
of
Vater
. Common Bile Duct Neoplasms / genetics. Loss of Heterozygosity.
Pancreatic
Neoplasms / genetics
[MeSH-minor]
Aged. Aged, 80 and over.
Carcinoma
,
Pancreatic
Ductal / genetics.
Carcinoma
,
Pancreatic
Ductal / surgery. Female. Genes, Tumor Suppressor. Humans. Male. Middle Aged. Mutation. Pancreatectomy. Pilot Projects. Predictive Value of Tests. Prognosis. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins p21(ras). Retrospective Studies. Survival Analysis. ras Proteins / genetics
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Surgery. 2007 May;141(5):610-8
[
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]
(PMID = 18677542.001).
[ISSN]
1873-4626
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras); EC 3.6.5.2 / ras Proteins
75.
Furuse J, Okusaka T, Funakoshi A, Yamao K, Nagase M, Ishii H, Nakachi K, Ueno H, Ikeda M, Morizane C, Horikawa Y, Mizuno N:
Early phase II study of uracil-tegafur plus doxorubicin in patients with unresectable advanced biliary tract cancer.
Jpn J Clin Oncol
; 2006 Sep;36(9):552-6
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[Title]
Early phase II study of uracil-tegafur plus doxorubicin in patients with unresectable advanced biliary tract
cancer
.
BACKGROUND: Standard chemotherapy for advanced biliary tract
cancer
has not been established.
The purpose of this study was to evaluate the efficacy and toxicity of a combination chemotherapy of uracil-tegafur (UFT) and doxorubicin in patients with unresectable advanced biliary tract
cancer
.
METHODS: Patients with histologically or cytologically confirmed, measurable biliary tract
cancer
, including intrahepatic or extrahepatic cholangiocarcinoma, gallbladder
cancer
and
ampulla
of
Vater cancer
, which was not amenable to surgery, were eligible for the study.
CONCLUSIONS: Combination chemotherapy of UFT and doxorubicin was well tolerated and showed preliminary moderate activity against advanced biliary tract
cancer
.
Genetic Alliance.
consumer health - Biliary Tract Cancer
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(PMID = 16887837.001).
[ISSN]
0368-2811
[Journal-full-title]
Japanese journal of clinical oncology
[ISO-abbreviation]
Jpn. J. Clin. Oncol.
[Language]
eng
[Publication-type]
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Japan
[Chemical-registry-number]
1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 80168379AG / Doxorubicin; 1-UFT protocol
76.
Singh S, Sachdev AK, Chaudhary A, Agarwal AK:
Palliative surgical bypass for unresectable periampullary carcinoma.
Hepatobiliary Pancreat Dis Int
; 2008 Jun;7(3):308-12
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[Title]
Palliative surgical bypass for unresectable periampullary
carcinoma
.
BACKGROUND: Around 60% to 80% of patients with periampullary
carcinoma
are unresectable either due to distant metastasis or local vascular invasion.
This study was conducted to assess the results of palliative surgical bypass for patients with unresectable periampullary
carcinoma
at our hospital, a tertiary referral center of Northern India.
METHOD: The study group comprised 204 patients who had undergone surgical bypass for advanced periampullary
carcinoma
over the last 15 years.
RESULTS: Between January 1990 and December 2004, 204 patients (128 males, 76 females) consisting of 179 patients with
carcinoma
of head of the pancreas, 14 patients with
ampullary
carcinoma
, 8 patients with lower end cholangiocarcinoma and 3 patients with duodenal
carcinoma
underwent surgical bypass.
[MeSH-major]
Ampulla
of
Vater
.
Carcinoma
/ surgery. Common Bile Duct Neoplasms / surgery. Gastrostomy / methods. Jejunostomy / methods. Palliative Care / methods
[MeSH-minor]
Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged.
Neoplasm
Staging. Prospective Studies. Treatment Outcome
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(PMID = 18522888.001).
[ISSN]
1499-3872
[Journal-full-title]
Hepatobiliary & pancreatic diseases international : HBPD INT
[ISO-abbreviation]
HBPD INT
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
China
77.
Park SK, Andreotti G, Sakoda LC, Gao YT, Rashid A, Chen J, Chen BE, Rosenberg PS, Shen MC, Wang BS, Han TQ, Zhang BH, Yeager M, Chanock S, Hsing AW:
Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
Carcinogenesis
; 2009 Apr;30(4):606-14
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Biliary tract cancers, encompassing gallbladder, extrahepatic bile duct and
ampulla
of
Vater
cancers, are uncommon but often fatal malignancies.
This study included subjects who completed an interview and provided blood, which totaled 411 biliary tract
cancer
and 893 biliary stone patients and 786 healthy Shanghai residents.
The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2.0, 95% confidence interval (CI), 1.3-3.0] and bile duct cancers (OR = 1.8, 95% CI = 1.1-3.1), whereas the CYP1A1 Ex7 + 131 (rs1048943) G allele was associated with
ampulla
of
Vater cancer
(OR = 2.9, 95% CI = 1.5-5.4).
After taking into account multiple comparisons for SNPs within each gene, CYP1A1 was significantly associated with gallbladder (P = 0.004) and
ampulla
of
Vater
cancers (P = 0.01), but borderline with bile duct
cancer
(P = 0.06).
The effect of CYP1A1 IVS1 + 606 on gallbladder
cancer
was more pronounced among non-obese (body mass index < 23) (OR = 3.3, 95% CI = 1.8-6.1; P interaction = 0.001).
Among women taking oral contraceptives, the effect of SHBG Ex8 + 6 (rs6259) on gallbladder
cancer
(OR = 6.7, 95% CI = 2.2-20.5; P interaction = 0.001) and stones (OR = 2.3, 95% CI = 1.1-4.9; P-interaction = 0.05) was statistically significant.
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(PMID = 19168589.001).
[ISSN]
1460-2180
[Journal-full-title]
Carcinogenesis
[ISO-abbreviation]
Carcinogenesis
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CO / N01-CO-12400
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Contraceptives, Oral, Hormonal; 0 / Hormones; 9007-49-2 / DNA; EC 1.14.14.1 / Cytochrome P-450 CYP1A1
[Other-IDs]
NLM/ PMC2664453
78.
Peng SY, Hong DF, Liu YB, Li JT, Tao F, Tan ZJ:
[A pancreas suture-less type II binding pancreaticogastrostomy].
Zhonghua Wai Ke Za Zhi
; 2009 Dec 1;47(23):1764-6
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METHODS: From November 2008 to May 2009, 26 patients underwent pancreaticoduodenectomy and mid-segmentectomy of pancreas with type II BPG reconstruction, including 13 cases
of pancreatic
head
cancer
, 3 cases of duodenal adenocarcinoma, 2 cases
of ampullary
carcinoma
, 4 cases of cholangiocarcinoma, 1 case of bile duct cell severe atypical hyperplasia, and 1 case of stomach
cancer
.
No mortality or
pancreatic
leakage occurred.
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(PMID = 20193541.001).
[ISSN]
0529-5815
[Journal-full-title]
Zhonghua wai ke za zhi [Chinese journal of surgery]
[ISO-abbreviation]
Zhonghua Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Evaluation Studies; Journal Article
[Publication-country]
China
79.
Tsukada K, Takada T, Miyazaki M, Miyakawa S, Nagino M, Kondo S, Furuse J, Saito H, Tsuyuguchi T, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology:
Diagnosis of biliary tract and ampullary carcinomas.
J Hepatobiliary Pancreat Surg
; 2008;15(1):31-40
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[Title]
Diagnosis of
biliary tract and
ampullary
carcinomas.
Diagnostic methods for biliary tract
carcinoma
and the efficacy of these methods are discussed.
Neither definite methods for early
diagnosis
nor specific markers are available in this disease.
Diagnoses of extrahepatic bile duct
cancer
and
ampullary
carcinoma
are often made based on the presence of obstructive jaundice.
Although rare, abdominal pain and pyrexia, as well as abnormal findings of the hepatobiliary system detected by hemato-biochemical examination, serve as a clue to making a
diagnosis of
these diseases.
On the other hand, the early
diagnosis of
gallbladder
cancer
is scarcely possible on the basis of clinical symptoms, so when this
cancer
is found with the onset of abdominal pain and jaundice, it is already advanced at the time of detection, thus making a cure difficult.
When gallbladder
cancer
is suspected, enhanced CT is carried out.
However, direct biliary tract imaging is necessary for making a precise
diagnosis of
the horizontal extension of bile duct
cancer
.
[MeSH-major]
Ampulla
of
Vater
. Biliary Tract Neoplasms /
diagnosis
.
Carcinoma
/
diagnosis
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[
15887157.001
]
(PMID = 18274842.001).
[ISSN]
0944-1166
[Journal-full-title]
Journal of hepato-biliary-pancreatic surgery
[ISO-abbreviation]
J Hepatobiliary Pancreat Surg
[Language]
eng
[Publication-type]
Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
[Publication-country]
Japan
[Other-IDs]
NLM/ PMC2794353
[Investigator]
Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
80.
Chen JY, Cai SW, Zhang WZ, Huang XQ, Liu R, Wang J, Chen YL, Ji WB, Shi XJ, Chen MY, Liu ZW, Zhao XQ, Feng YQ, Huang ZQ, Dong JH:
[Determinants of long-term survival after pancreaticoduodenectomy for ampulla of Vater carcinoma].
Zhonghua Yi Xue Za Zhi
; 2009 Dec 29;89(48):3409-12
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[Title]
[Determinants of long-term survival after pancreaticoduodenectomy for
ampulla
of
Vater carcinoma
].
OBJECTIVE: To investigate the determinants of long-term survival for
ampulla
of
Vater carcinoma
treated by pancreaticoduodenectomy.
METHODS: A total of 77 patients with
ampulla
of
Vater carcinoma
undergoing pancreaticoduodenectomy were reviewed.
Univariate analysis showed that perioperative serum carcinoembryonic antigen (CEA) level (P = 0.012), tumor invasion depth (P = 0.000), UICC stage (P = 0.000) and tumor size (P = 0.001) were significant prognostic factors of
ampulla
of
Vater carcinoma
; in multivariate analysis, only the tumor size (P = 0.000) was an independent prognostic factor of
ampulla
of
Vater carcinoma
.
[MeSH-major]
Ampulla
of
Vater
/ surgery.
Carcinoma
/ surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / mortality
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(PMID = 20223115.001).
[ISSN]
0376-2491
[Journal-full-title]
Zhonghua yi xue za zhi
[ISO-abbreviation]
Zhonghua Yi Xue Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
81.
Voutsadakis IA, Doumas S, Tsapakidis K, Papagianni M, Papandreou CN:
Bone and brain metastases from ampullary adenocarcinoma.
World J Gastroenterol
; 2009 Jun 7;15(21):2665-8
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[Title]
Bone and brain metastases from
ampullary
adenocarcinoma.
Ampullary
carcinoma
is the second most common
cancer
of the peri-
ampullary
area after
pancreatic
carcinoma
and metastasizes mostly intra-abdominally and to the liver.
In this report we describe the case of a patient with resected adenocarcinoma of the
ampulla
of
Vater
who developed skeletal metastases in the lower extremity and brain metastases.
[MeSH-major]
Adenocarcinoma / pathology.
Ampulla
of
Vater
/ pathology. Bone Neoplasms / secondary. Brain Neoplasms / secondary. Common Bile Duct Neoplasms / pathology
[MeSH-minor]
Diagnosis
, Differential. Fatal Outcome. Female. Humans. Middle Aged.
Neoplasm
Metastasis
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]
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]
[Cites]
World J Surg. 2006 Jun;30(6):985-91
[
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]
(PMID = 19496199.001).
[ISSN]
2219-2840
[Journal-full-title]
World journal of gastroenterology
[ISO-abbreviation]
World J. Gastroenterol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
China
[Other-IDs]
NLM/ PMC2691500
82.
Ji JS, Kim HK, Kim SS, Cho YS, Chae HS, Won YD:
Periampullary choledochoduodenal fistula associated with ampulla of Vater carcinoma.
Dig Dis Sci
; 2007 Jun;52(6):1592-3
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[Title]
Periampullary choledochoduodenal fistula associated with
ampulla
of
Vater carcinoma
.
[MeSH-major]
Biliary Fistula / etiology.
Carcinoma
/ complications. Common Bile Duct Neoplasms / complications. Intestinal Fistula / etiology
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]
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0163-2116
[Journal-full-title]
Digestive diseases and sciences
[ISO-abbreviation]
Dig. Dis. Sci.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
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United States
83.
Dittrick GW, Mallat DB, Lamont JP:
Management of ampullary lesions.
Curr Treat Options Gastroenterol
; 2006 Sep;9(5):371-6
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[Title]
Management
of ampullary
lesions.
Adenomatous lesions of the
ampulla
of
Vater
are relatively rare neoplasms that raise many questions regarding standard management.
Adenocarcinoma often will be found in
ampullary
lesions and should be treated by pancreaticoduodenectomy (PD).
Preoperative endoscopic biopsies should be obtained to identify
carcinoma
, but they have high false-negative rates and cannot be relied upon to rule out malignancy.
Intraoperative frozen section evaluation should be requested routinely during AMP, with conversion to PD if
carcinoma
is demonstrated.
Adjuvant chemoradiation has a very limited role in the treatment
of ampullary
carcinoma
and ideally should be offered in the setting of a clinical trial.
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[ISSN]
1092-8472
[Journal-full-title]
Current treatment options in gastroenterology
[ISO-abbreviation]
Curr Treat Options Gastroenterol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
84.
Terasawa H, Uchiyama K, Tani M, Kawai M, Tsuji T, Tabuse K, Kobayashi Y, Taniguchi K, Yamaue H:
Impact of lymph node metastasis on survival in patients with pathological T1 carcinoma of the ampulla of Vater.
J Gastrointest Surg
; 2006 Jun;10(6):823-8
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[Title]
Impact of lymph node metastasis on survival in patients with pathological T1
carcinoma
of the
ampulla
of
Vater
.
To determine the prognostic factors for patients with pathological T1 (pT1)
carcinoma
of the
ampulla
of
Vater
, 36 consecutive patients with
carcinoma
of the
ampulla
of
Vater
who underwent surgery were retrospectively analyzed in terms of clinicopathological features.
[MeSH-major]
Ampulla
of
Vater
. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Lymphatic Metastasis
[MeSH-minor]
Aged. Chemotherapy, Adjuvant. Female. Humans. Japan / epidemiology. Lymph Node Excision. Male. Middle Aged. Multivariate Analysis.
Neoplasm
Staging. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Analysis
ClinicalTrials.gov.
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.
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[Cites]
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[
14966929.001
]
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]
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9637545.001
]
[Cites]
Ann Surg. 1997 May;225(5):590-9; discussion 599-600
[
9193186.001
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]
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Dig Surg. 2003;20(6):511-5
[
14506332.001
]
(PMID = 16769538.001).
[ISSN]
1091-255X
[Journal-full-title]
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
[ISO-abbreviation]
J. Gastrointest. Surg.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
85.
van Roest MH, Gouw AS, Peeters PM, Porte RJ, Slooff MJ, Fidler V, de Jong KP:
Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization.
Ann Surg
; 2008 Jul;248(1):97-103
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OBJECTIVE: To study the impact of perineural growth as a prognostic factor in periampullary adenocarcinoma (
pancreatic
head,
ampulla
of
Vater
, distal bile duct, and duodenal
carcinoma
).
SUMMARY BACKGROUND DATA:
Pancreatic
head
carcinoma
is considered to have the worst prognosis of the periampullary carcinomas.
RESULTS: Perineural growth was present in 49% of the cases (37 of the 51 patients with
pancreatic
head
carcinoma
; 7 of the 30 patients with
ampulla
of
Vater carcinoma
; 7 of the 19 with distal bile duct
carcinoma
; and 8 of the 21 with duodenal
carcinoma
).
[MeSH-major]
Adenocarcinoma / mortality. Adenocarcinoma / surgery.
Pancreatic
Neoplasms / mortality.
Pancreatic
Neoplasms / surgery. Pancreaticoduodenectomy
[MeSH-minor]
Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Multivariate Analysis.
Neoplasm
Invasiveness. Peripheral Nerves / pathology. Prognosis. Survival Analysis
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[CommentIn]
Ann Surg. 2009 Mar;249(3):545; author reply 545-6
[
19247055.001
]
(PMID = 18580212.001).
[ISSN]
1528-1140
[Journal-full-title]
Annals of surgery
[ISO-abbreviation]
Ann. Surg.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
86.
Albores-Saavedra J, Schwartz AM, Batich K, Henson DE:
Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program.
J Surg Oncol
; 2009 Dec 1;100(7):598-605
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[Title]
Cancers of the
ampulla
of
vater
: demographics, morphology, and survival based on 5,625 cases from the SEER program.
BACKGROUND: Cancers of the
ampulla
are unusual and morphologically heterogeneous.
Based on pathologic and epidemiologic characteristics of
cancer
of the
ampulla
available in SEER, important clinicopathological correlations can be made.
METHODS: All patients with
cancer
of the
ampulla
were identified between 1973 and 2005.
RESULTS: There were 5,625 cases
of ampullary
cancer
.
Ampullary
cancer
has been increasing since 1973.
[MeSH-major]
Ampulla
of
Vater
/ pathology.
Carcinoma
/ mortality. Common Bile Duct Neoplasms / mortality
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(PMID = 19697352.001).
[ISSN]
1096-9098
[Journal-full-title]
Journal of surgical oncology
[ISO-abbreviation]
J Surg Oncol
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
87.
Dai YC, Ho CL, Tsai YC, Hsu YH, Chang YC, Liu HS, Chen HH, Chow NH:
Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval.
J Cancer Res Clin Oncol
; 2005 Feb;131(2):94-100
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[Title]
Allelic loss of 14q32 in the pathogenesis of gastrointestinal and
ampullary
malignancies: mapping of the target region to a 17 cM interval.
PURPOSE: The genetic basis for gastrointestinal and
ampullary
carcinomas remains uncertain.
METHODS: We screened the allelic status on 16 chromosomal arms in a patient with synchronous
ampullary
carcinoma
and gastric
cancer
, but who had no family history of familial
cancer
syndrome.
The significance of the shared 14q deletion was examined on clinical cohorts of sporadic gastric (n=12) and
ampullary
(n=10)
carcinoma
, respectively.
RESULTS: The synchronous gastric and
ampullary
carcinomas had no frameshift mutations in the APC, MSH2, MSH3, and MSH6 genes.
The same allelic loss was also detected in one
of ampullary
carcinomas (10%) and two of gastric cancers (16.7%).
CONCLUSIONS: This study illustrates a paradigm using molecular genetic approach in identifying chromosome 14q32 that may harbor a tumor suppressor gene involved in the pathogenesis of a subset of gastrointestinal and
ampullary
malignancies.
[MeSH-major]
Ampulla
of
Vater
/ pathology.
Carcinoma
/ genetics. Chromosomes, Human, Pair 14 / genetics. Common Bile Duct Neoplasms / genetics. Genetic Predisposition to Disease. Loss of Heterozygosity / genetics. Stomach Neoplasms / genetics
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(PMID = 15503134.001).
[ISSN]
0171-5216
[Journal-full-title]
Journal of cancer research and clinical oncology
[ISO-abbreviation]
J. Cancer Res. Clin. Oncol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Germany
88.
Hosaka A, Nagayoshi M, Sugizaki K, Masaki Y:
Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report.
World J Surg Oncol
; 2010;8:41
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[Title]
Gallbladder perforation associated with
carcinoma
of the duodenal
papilla
: a case report.
A tumor of the
ampulla
of
Vater
causes gradually progressive symptoms, and is rarely associated with perforation of the gallbladder.
CASE PRESENTATION: A 56-year-old man with
carcinoma
of the
ampulla
of
Vater
presented with spontaneous gallbladder perforation and localized bile peritonitis.
Postoperative upper gastrointestinal endoscopy demonstrated a slightly enlarged duodenal
papilla
, and biopsy revealed adenocarcinoma of the
ampulla
.
CONCLUSION:
Ampullary
carcinoma
can be associated with gallbladder perforation and present with acute manifestations.
[MeSH-major]
Adenocarcinoma / pathology.
Ampulla
of
Vater
/ pathology. Common Bile Duct Neoplasms / pathology. Gallbladder / pathology. Gallbladder Diseases /
diagnosis
[MeSH-minor]
Abdominal Pain. Humans. Male. Middle Aged. Pancreaticoduodenectomy. Peritonitis /
diagnosis
. Rupture, Spontaneous. Tomography, X-Ray Computed. Treatment Outcome
MedlinePlus Health Information.
consumer health - Gallbladder Diseases
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[
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Arch Surg. 1999 May;134(5):526-32
[
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]
(PMID = 20487525.001).
[ISSN]
1477-7819
[Journal-full-title]
World journal of surgical oncology
[ISO-abbreviation]
World J Surg Oncol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC2887867
89.
Ishida M, Egawa S, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Furukawa T, Unno M:
Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma.
J Hepatobiliary Pancreat Surg
; 2007;14(5):522-5
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[Title]
Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for
cancer
of
Vater
's
papilla
associated with intraductal papillary-mucinous adenoma.
A 72-year-old woman, who had undergone pylorus-preserving pancreatoduodenectomy 3 years before for
cancer
of
Vater
's
papilla
associated with a branch-type intraductal papillary-mucinous adenoma (IPMA), developed dilatation of the main duct and a nodular lesion in the remnant pancreas.
Total pancreatectomy was performed, which revealed that the lesion was intraductal papillary-mucinous adenocarcinoma (IPMC) with minimal invasion, suggesting the metachronous multicentric occurrence of this intraductal papillary-mucinous
neoplasm
(IPMN).
Because there were no
malignant
cells at the pancreaticojejunostomy, and because the histological appearance of the main-duct IPMC was different from that of the IPMA in the primary specimen, the main-duct IPMC was thought to be of different origin from the IPMA.
[MeSH-major]
Adenocarcinoma, Mucinous / surgery.
Ampulla
of
Vater
.
Carcinoma
,
Pancreatic
Ductal /
diagnosis
. Common Bile Duct Neoplasms / surgery. Neoplasms, Multiple Primary /
diagnosis
.
Pancreatic
Neoplasms /
diagnosis
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consumer health - Pancreatic Cancer
.
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(PMID = 17909725.001).
[ISSN]
0944-1166
[Journal-full-title]
Journal of hepato-biliary-pancreatic surgery
[ISO-abbreviation]
J Hepatobiliary Pancreat Surg
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
90.
Kim K, Chie EK, Jang JY, Kim SW, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW:
Role of adjuvant chemoradiotherapy for ampulla of Vater cancer.
Int J Radiat Oncol Biol Phys
; 2009 Oct 1;75(2):436-41
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[Title]
Role of adjuvant chemoradiotherapy for
ampulla
of
Vater cancer
.
PURPOSE: To evaluate the role of adjuvant chemoradiotherapy for
ampulla
of
Vater cancer
.
METHODS AND MATERIALS: Between January 1991 and December 2002, 118 patients with
ampulla
of
Vater cancer
underwent en bloc resection.
CONCLUSIONS: Adjuvant chemoradiotherapy may enhance locoregional control and overall survival in patients with
ampulla
of
Vater cancer
after curative resection, especially in those with nodal involvement.
[MeSH-major]
Ampulla
of
Vater
. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / radiotherapy
[MeSH-minor]
Adult. Age Factors. Aged. Antimetabolites, Antineoplastic / administration & dosage. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Humans. Lymphatic Irradiation. Lymphatic Metastasis / radiotherapy. Male. Middle Aged.
Neoplasm
Staging. Proportional Hazards Models. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate
Hazardous Substances Data Bank.
FLUOROURACIL
.
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(PMID = 19394162.001).
[ISSN]
1879-355X
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
91.
Roh YH, Kim YH, Lee HW, Kim SJ, Roh MS, Jeong JS, Jung GJ:
The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis.
Hepatogastroenterology
; 2007 Sep;54(78):1641-4
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[Title]
The clinicopathologic and immunohistochemical characteristics of
ampulla
of
Vater carcinoma
: the intestinal type is associated with a better prognosis.
BACKGROUND/AIMS: We wanted to compare the clinicopathological parameters with the immunohistochemical expression patterns and patient survival for the intestinal type (IT) and the pancreatobiliary type (PT) of
ampulla
of
Vater carcinoma
.
Ampulla
of
Vater carcinoma
can be classified histologically into either IT or PT.
METHODOLOGY: From September, 1995, to February, 2004, 34 patients with the pathologic
diagnosis of
ampulla
of
Vater carcinoma
were retrospectively reviewed and the prognostic factors were analyzed.
RESULTS: The 5-year survival rate of the 34 patients with
ampulla
of
Vater carcinoma
was 58.8%.
A study with a larger number samples would probably elucidate the different clinical course between these two types of
ampulla
of
Vater carcinoma
.
[MeSH-major]
Ampulla
of
Vater
/ pathology.
Carcinoma
/ pathology. Common Bile Duct Neoplasms / pathology. Gene Expression Regulation, Neoplastic. Immunohistochemistry / methods
NCI CPTAC Assay Portal.
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.
NCI CPTAC Assay Portal.
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(PMID = 18019683.001).
[ISSN]
0172-6390
[Journal-full-title]
Hepato-gastroenterology
[ISO-abbreviation]
Hepatogastroenterology
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Greece
[Chemical-registry-number]
0 / Glucose Transporter Type 1; 0 / Keratin-20; 0 / Keratin-7; 0 / MUC2 protein, human; 0 / Mucin-2; 0 / Mucins; 0 / SLC2A1 protein, human
92.
Menon KV, Gomez D, Smith AM, Anthoney A, Verbeke CS:
Impact of margin status on survival following pancreatoduodenectomy for cancer: the Leeds Pathology Protocol (LEEPP).
HPB (Oxford)
; 2009 Feb;11(1):18-24
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[Title]
Impact of margin status on survival following pancreatoduodenectomy for
cancer
: the Leeds Pathology Protocol (LEEPP).
BACKGROUND: In a previous study we reported an 85% R1 rate for
pancreatic
cancer
following the use of the rigorous, fully standardized Leeds Pathology Protocol (LEEPP).
METHODS: Clinicopathological features, including exact site and multifocality of margin involvement, and survival were collated from a prospective series of 83 pancreatoduodenectomies for
pancreatic
(n = 27),
ampullary
(n = 24) and bile duct
cancer
(n = 32).
RESULTS: The R1 rate was high in
pancreatic
(82%) and bile duct (72%)
cancer
and significantly lower in
ampullary
cancer
(25%).
Margin status correlated with survival in the entire cohort (P = 0.006) and the
pancreatic
subgroup (P = 0.046).
CONCLUSIONS: Margin involvement in
pancreatic
cancer
is a frequent and prognostically significant finding when specimens are assessed using the LEEPP.
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