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Items 1 to 100 of about 220
1. Khalid K, Alam MK, Al-Shakweer WA, Al-Teimi IN: Granular cell tumour of the ampulla of Vater. J Postgrad Med; 2005 Jan-Mar;51(1):36-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumour of the ampulla of Vater.
  • Granular cell tumour (GCT) is a rare soft tissue neoplasm commonly encountered in the head and neck region, skin and subcutaneous tissue.
  • The neoplasm constitutes less than 10% of all benign tumours of the extra-hepatic biliary tree.
  • No case of GCT involving the ampulla of Vater has been reported in the literature to date.
  • We report a case of benign GCT involving the ampullary region in a 44-year-old Ethiopian male.
  • Preoperative diagnosis was available on ERCP and deep biopsy.
  • The patient was managed by debulking resection and biliary-enteric bypass and is symptom-free with no evidence of tumour progression after a follow-up of one year.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 15793336.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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2. Filippou DK, Pashalidis N, Skandalakis P, Rizos S: Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. J Postgrad Med; 2006 Jul-Sep;52(3):204-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice.
  • Malignant gastrointestinal stromal tumor (GIST) consists a rare neoplasm, developing in small intestine and stomach.
  • The present case refers to a 65 years old female patient with a GIST of the ampulla of Vater presenting with obstructive jaundice.
  • Diagnosis was achieved pre-operatively by biopsies collected through diagnostic ERCP.
  • The tumour was locally excised, with preservation of the ampulla.
  • Malignant GIST of the ampulla of the Vater is extremely rare as only few similar cases have been described in the literature.
  • Despite the unavailability of EUS-FNA, the diagnosis was set preoperatively and the tumor was resected.
  • [MeSH-major] Ampulla of Vater. Gastrointestinal Stromal Tumors / complications. Jaundice, Obstructive / etiology
  • [MeSH-minor] Aged. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Cholangiopancreatography, Endoscopic Retrograde. Disease-Free Survival. Female. Humans. Proto-Oncogene Proteins c-kit / analysis

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  • (PMID = 16855323.001).
  • [ISSN] 0022-3859
  • [Journal-full-title] Journal of postgraduate medicine
  • [ISO-abbreviation] J Postgrad Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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3. Ferrando Marco J, Pallas Regueira A, Moro Valdezate D, Fernández Martínez C: [Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma]. Rev Esp Enferm Dig; 2007 Apr;99(4):235-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma].
  • [Transliterated title] Tumor de colisión periampular.
  • We report the case of a periampullary collision tumor, in which a duodenal-wall carcinoid and an adenocarcinoma of the head of the pancreas coexisted.
  • Solid cords and nests of neuroendocrine cells in the duodenal wall formed the carcinoid tumor, whereas the other neoplasm was made up of a well-differentiated adenocarcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Carcinoid Tumor / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17590108.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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4. Kucuk C, Artis T, Baskol M, Akgun H, Sozuer E: Diagnosis, treatment and prognosis of carcinoid tumour of the ampulla of Vater: long-term follow-up of a case. Acta Chir Belg; 2005 May-Jun;105(3):313-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis, treatment and prognosis of carcinoid tumour of the ampulla of Vater: long-term follow-up of a case.
  • Carcinoid tumours of the ampulla of Vater are extremely rare.
  • In this report, we present a long-term follow-up of a new case with carcinoid tumour of the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / surgery

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  • (PMID = 16018528.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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5. Leung VK, Lee SW, Yuen NW, Kung NN, Loke TK: Epigastric pain in a patient with neurofibromatosis type 1. Hong Kong Med J; 2005 Jun;11(3):213-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients with neurofibromatosis type 1 are at increased risk of developing carcinoid tumours of the duodenum, particularly in the ampulla of Vater.
  • Aggressive surgery with pancreatoduodenectomy is recommended for all ampullary carcinoid tumours because of their propensity to metastasise.
  • Evaluation using magnetic resonance cholangiopancreatography and side-viewing duodenoscopy revealed a submucosal tumour at the ampulla of Vater causing pancreatobiliary ductal obstruction and dilation.
  • The ampullary tumour was overlooked initially by forward-viewing endoscopy.
  • Histological examination of the surgically resected specimen confirmed the presence of a carcinoid tumour, with metastasis to peri-pancreatic lymph nodes.


6. Matsushita M, Kobayashi Y, Kobayashi H, Nagasawa M, Sato Y, Nakamura H: A case of gastrointestinal stromal tumour of the ampulla of Vater. Dig Liver Dis; 2005 Apr;37(4):275-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of gastrointestinal stromal tumour of the ampulla of Vater.
  • Gastrointestinal stromal tumour rarely develops in the duodenal ampulla region.
  • We report here a case of gastrointestinal stromal tumour of the ampulla of Vater found in a 44-year-old Japanese man presenting with biliary obstruction.
  • The postmortem examination showed a large Borrman type III-like tumour in the duodenal ampullary region with direct invasion of the pancreas and extrahepatic bile duct as well as metastases to the liver and regional lymph nodes.
  • The duct orifice was located at the centre of the tumour.
  • Microscopically, the tumour consisted of anaplastic spindle cells with high mitotic activity (90 mitoses per 50 high-power fields).
  • The final diagnosis was high-grade malignant gastrointestinal stromal tumour of the ampulla of Vater.
  • Considering the recent advances in the diagnosis and treatment of gastrointestinal stromal tumour, this neoplasm should be included in the differential diagnosis of the tumours appearing in the duodenal ampulla region.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Gastrointestinal Stromal Tumors / pathology

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  • (PMID = 15788212.001).
  • [ISSN] 1590-8658
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD34; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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7. Rohan VS, Narendra H, Patel JJ, Tankshali RA: Carcinoid of ampulla of Vater. Indian J Cancer; 2007 Apr-Jun;44(2):90-2
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  • [Title] Carcinoid of ampulla of Vater.
  • Carcinoid tumors of ampulla are rare clinical entities.
  • Since the metastatic potential and the tumor size have no correlation, unlike in duodenal carcinoids, pancreatoduodenectomy is considered the treatment of choice.
  • Here we present a case of carcinoid of ampulla presenting to our department.
  • [MeSH-major] Ampulla of Vater. Carcinoid Tumor. Common Bile Duct Neoplasms
  • [MeSH-minor] Abdominal Pain. Adult. Biopsy. Female. Humans. Laparotomy. Neoplasm Metastasis

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  • [CommentIn] Indian J Cancer. 2008 Jan-Mar;45(1):37 [18453741.001]
  • (PMID = 17938486.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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8. Chang S, Lim JH, Choi D, Kim SK, Lee WJ: Differentiation of ampullary tumor from benign papillary stricture by thin-section multidetector CT. Abdom Imaging; 2008 Jul-Aug;33(4):457-62
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  • [Title] Differentiation of ampullary tumor from benign papillary stricture by thin-section multidetector CT.
  • The objective of this paper was to determine the criteria for differentiation of ampullary tumor from benign papillary stricture using thin-section multidetector CT images.
  • Multidetector CT images with 2.5 mm slice-thickness in 57 consecutive patients (24 with ampulla of Vater tumor and 33 with benign papillary stricture) with extrahepatic duct dilatation due to ampullary obstruction were reviewed retrospectively.
  • Multiple logistic regression analysis showed the papilla/papillary mass size was the only independently differentiating variable of ampullary tumor from benign stricture (P = 0.016) with an odds ratio of 2.424 (95% confidence interval, 1.179-4.903).
  • Ampullary tumor and benign papillary stricture could be effectively differentiated by thin-section multidetector CT based on papilla/papillary mass size.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Diseases / radiography. Common Bile Duct Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Constriction, Pathologic / radiography. Diagnosis, Differential. Female. Humans. Logistic Models. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 17712590.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Hsu SD, Chan DC, Hsieh HF, Chen TW, Yu JC, Chou SJ: Ectopic pancreas presenting as ampulla of Vater tumor. Am J Surg; 2008 Apr;195(4):498-500

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic pancreas presenting as ampulla of Vater tumor.
  • Ectopic pancreas is relatively rare and is defined as pancreatic tissue that is situated abnormally, has no contact with the normal pancreas, and has its own ductal system and blood supply.
  • Most patients with an ectopic pancreas are asymptomatic, and, if present, symptoms are nonspecific and depend on the site of the lesion and the different complications encountered.
  • Herein, we report a patient presenting with symptoms of ampullary tumor with obstructive jaundice, but the imaging study did not suggest the possibility of ectopic pancreas preoperatively.
  • [MeSH-major] Ampulla of Vater. Choristoma / diagnosis. Common Bile Duct Diseases / diagnosis. Pancreas
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / diagnosis. Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18304504.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Mavroudis N, Rafailidis S, Symeonidis N, Aimoniotou E, Antonopoulos V, Evgenidis N, Venizelos L, Sakadamis A: Carcinoid of the ampulla of Vater--report of two cases. Acta Chir Belg; 2005 Apr;105(2):213-6
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  • [Title] Carcinoid of the ampulla of Vater--report of two cases.
  • Carcinoid of the ampulla of Vater is extremely rare, accounting for less than 0.3% of all gastro-intestinal carcinoids.
  • To our knowledge, only 80 cases of ampullary carcinoid have been reported in the literature to date.
  • Ampullary carcinoid is more commonly presented with jaundice or upper abdominal discomfort and diagnosis is more often made postoperatively due to submucosal spread of the tumour.
  • As metastatic potential cannot be predicted by tumour size, Whipple pancreatoduodenectomy rather than local excision is considered to be the treatment of choice.
  • We report here two cases of ampullary carcinoid treated in our department.
  • [MeSH-major] Ampulla of Vater. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy / methods. Risk Assessment. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15906919.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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11. Chang SK, Liang WT, Thamboo TP: Inflammatory pseudotumour arising from periampullary carcinoid: a "cancer-like" tumour in a "fake" tumour. Singapore Med J; 2009 Mar;50(3):e100-1
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  • [Title] Inflammatory pseudotumour arising from periampullary carcinoid: a "cancer-like" tumour in a "fake" tumour.
  • We present a 52-year-old Chinese woman with a carcinoid at the ampulla of Vater, a site far less common than other areas of the gastrointestinal tract.
  • An intraoperative biopsy of the enlarged nodes was negative for malignancy and postoperative histology of the large pancreatic mass yielded a surprising finding of a carcinoid tumour at the ampulla of Vater with a large inflammatory pancreatic mass adherent to the portal vein.
  • This is an uncommon case associated with "pseudotumour pancreatitis", causing biliary and pancreatic duct obstruction mimicking a large tumour in the head of the pancreas.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoid Tumor / complications. Gallbladder Neoplasms / complications. Granuloma, Plasma Cell / etiology

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  • (PMID = 19352550.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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12. Kim K, Chie EK, Jang JY, Kim SW, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW: Role of adjuvant chemoradiotherapy for ampulla of Vater cancer. Int J Radiat Oncol Biol Phys; 2009 Oct 1;75(2):436-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Role of adjuvant chemoradiotherapy for ampulla of Vater cancer.
  • PURPOSE: To evaluate the role of adjuvant chemoradiotherapy for ampulla of Vater cancer.
  • METHODS AND MATERIALS: Between January 1991 and December 2002, 118 patients with ampulla of Vater cancer underwent en bloc resection.
  • Postoperative radiotherapy was delivered to the tumor bed and regional lymph nodes, for a total dose of up to 40 Gy delivered in 2-Gy fractions, with a planned 2-week rest period halfway through the treatment period.
  • CONCLUSIONS: Adjuvant chemoradiotherapy may enhance locoregional control and overall survival in patients with ampulla of Vater cancer after curative resection, especially in those with nodal involvement.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Age Factors. Aged. Antimetabolites, Antineoplastic / administration & dosage. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Humans. Lymphatic Irradiation. Lymphatic Metastasis / radiotherapy. Male. Middle Aged. Neoplasm Staging. Proportional Hazards Models. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies. Survival Rate

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  • (PMID = 19394162.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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13. Kawakami H, Kuwatani M, Onodera M, Hirano S, Kondo S, Nakanishi Y, Itoh T, Asaka M: Primary acinar cell carcinoma of the ampulla of Vater. J Gastroenterol; 2007 Aug;42(8):694-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary acinar cell carcinoma of the ampulla of Vater.
  • Acinar cell carcinoma of the pancreatobiliary system is a relatively rare malignant neoplasm arising usually in the pancreatic parenchyma.
  • We experienced a 68-year-old woman who presented with obstructive jaundice due to an ampullary mass 1.0 cm in diameter, detected by abdominal computed tomography and endoscopic examination.
  • The patient underwent a curative surgical operation, and histopathological examination revealed that the tumor was confined to the ampulla of Vater with no continuity to the pancreatic parenchyma.
  • The tumor cells showed acinar or tubular arrangement with eosinophilic to basophilic granular cytoplasm, findings identical to those of acinar cell carcinoma of the pancreas.
  • Immunohistochemically, the tumor cells were positive for lipase.
  • From these findings, we concluded that the tumor was primary acinar cell carcinoma arising in the ampulla of Vater, probably originating from heterotopic pancreatic tissue.
  • This is the first reported case of primary acinar cell carcinoma in the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Acinar Cell / diagnosis. Common Bile Duct Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Endosonography. Female. Follow-Up Studies. Humans. Middle Aged. Pancreaticoduodenectomy / methods. Tomography, X-Ray Computed

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  • (PMID = 17701134.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Park JS, Yoon DS, Kim KS, Choi JS, Lee WJ, Chi HS, Kim BR: Factors influencing recurrence after curative resection for ampulla of Vater carcinoma. J Surg Oncol; 2007 Mar 15;95(4):286-90
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  • [Title] Factors influencing recurrence after curative resection for ampulla of Vater carcinoma.
  • BACKGROUND: Carcinoma of the ampulla of Vater has a relatively higher resection rate, lower recurrence rate, and more favorable prognosis than other malignant tumors of the periampullary region.
  • Because of the relative low incidence of carcinoma of the ampulla of Vater, there have been few reports on the patterns and risk factors of recurrence after curative resection.
  • The aim of this study was to evaluate the patterns and risk factors of recurrence after curative resection of ampulla of Vater carcinoma.
  • MATERIALS AND METHODS: Between January 1992 and December 2002, 102 patients received radical resection for ampulla of Vater carcinoma at Yonsei University Medical Center.
  • Finally, 87 patients were reviewed and analyzed to assess predictors of tumor recurrence.
  • Lymph node metastasis was identified as an independent factor of tumor recurrence after curative resection for ampulla of Vater carcinoma.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Prognosis. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17326125.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Iacono C, Verlato G, Zamboni G, Scarpa A, Montresor E, Capelli P, Bortolasi L, Serio G: Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors. J Gastrointest Surg; 2007 May;11(5):578-88

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors.
  • OBJECTIVE: To evaluate the prognostic significance of different clinico-pathological and molecular factors, and to compare survival after standard and extended pancreaticoduodenectomy (PD) in ampulla of Vater adenocarcinoma (AVAC).
  • RESULTS: The overall 5- and 10-year tumor-related survival rates were 46% and 33%, respectively.
  • CONCLUSION: MSI and chromosome 17p status allow to better define prognosis within ampullary cancers at the same stage.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Chromosomes, Human, Pair 17 / genetics. Common Bile Duct Neoplasms / pathology. Loss of Heterozygosity / genetics. Pancreaticoduodenectomy
  • [MeSH-minor] Aged. Chromosomes, Human, Pair 18 / genetics. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Male. Microsatellite Instability. Middle Aged. Neoadjuvant Therapy. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 17468917.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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16. van der Gaag NA, ten Kate FJ, Lagarde SM, Busch OR, van Gulik TM, Gouma DJ: Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater. Br J Surg; 2008 Jun;95(6):735-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater.
  • BACKGROUND: Lymphatic dissemination is an important predictor of survival in patients with adenocarcinoma of the ampulla of Vater.
  • METHODS: In a consecutive series of 160 patients with adenocarcinoma of the ampulla of Vater, 75 (46.9 per cent) had positive lymph nodes (N1).
  • The relation of extracapsular LNI with tumour stage and number of positive nodes was evaluated and its prognostic significance analysed.
  • Extracapsular LNI and tumour differentiation were independent prognostic factors for survival.
  • [MeSH-major] Adenocarcinoma / secondary. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Hospital Mortality. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Prognosis. Survival Analysis

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  • [Copyright] 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • [CommentIn] Br J Surg. 2008 Sep;95(9):1188; author reply 1188-9 [18690628.001]
  • (PMID = 18300268.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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17. Lee SY, Jang KT, Lee KT, Lee JK, Choi SH, Heo JS, Paik SW, Rhee JC: Can endoscopic resection be applied for early stage ampulla of Vater cancer? Gastrointest Endosc; 2006 May;63(6):783-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Can endoscopic resection be applied for early stage ampulla of Vater cancer?
  • BACKGROUND: Although endoscopic resection can provide a wide tumor resection with a negative resection margin, it is not yet recommended as a curative therapy for ampulla of Vater cancer.
  • METHODS: To investigate the microinvasion rate and the diagnostic accuracy of endoscopic biopsy to properly judge the safety of endoscopic resection for ampulla of Vater cancer.
  • PATIENTS: One hundred fifty-nine patients who were finally diagnosed with ampulla of Vater cancer after curative surgical resection.
  • For the 36 early stage (Tis or T1) cancers, we surveyed the presence of microlymphovascular invasion, gross appearance (intra-ampullary type, periampullary type, or mixed type), and pathologic subtype (intestinal type or pancreaticobiliary type).
  • MAIN OUTCOME MEASUREMENTS: Presence of microinvasion in early staged ampulla of Vater cancer.
  • CONCLUSIONS: Although endoscopic resection improves the low predictability of endoscopic biopsy, surgical resection should be performed for the T1 stage ampulla of Vater cancer because of the high lymphovascular invasion rate.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Sphincter of Oddi. Sphincterotomy, Endoscopic
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis

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  • [CommentIn] Gastrointest Endosc. 2006 May;63(6):789-91 [16650539.001]
  • (PMID = 16650538.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Sun JH, Chao M, Zhang SZ, Zhang GQ, Li B, Wu JJ: Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater. World J Gastroenterol; 2008 Aug 7;14(29):4709-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coexistence of small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater.
  • Small cell neuroendocrine carcinoma of the ampulla of Vater is extremely rare and different from the common ampullary adenocarcinoma.
  • The ampullary adenoma is also a rare neoplasm and has the potential to develop an adenocarcinoma.
  • We herein describe an unusual case of a small cell neuroendocrine carcinoma associated with a villous adenoma in the ampulla of Vater with emphasis on computed tomography (CT) and histopathological findings.
  • [MeSH-major] Adenoma, Villous / complications. Ampulla of Vater. Carcinoma, Neuroendocrine / complications. Common Bile Duct Neoplasms / complications

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  • [Cites] Hepatogastroenterology. 2001 Nov-Dec;48(42):1588-93 [11813580.001]
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  • (PMID = 18698690.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2738800
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19. Sanada Y, Yoshida K, Konishi K, Oeda M, Ohara M, Tsutani Y: Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes. Oncol Rep; 2006 May;15(5):1157-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes.
  • The purpose of this study was to examine the expression pattern of MUC5AC and SOX2 in ampulla of vater adenocarcinoma and evaluate the association between expression of these gastric epithelial markers and the histologic phenotype of ampulla of vater carcinoma.
  • Six surgically resected samples of ampulla of vater adenocarcinoma, including four intestinal type carcinomas and two pancreatobiliary type carcinomas, were studied.
  • However, in the centre of the tumour and in other invasive lesions, including vascular invasive lesions and metastatic lymph nodes, neither MUC5AC nor SOX2 was expressed.
  • Our immunohistochemistry data suggest that MUC5AC and SOX2 are associated with the pancreatobiliary phenotype of ampulla of vater carcinoma and involved in later events in carcinogenesis, such as invasion and metastasis.
  • [MeSH-major] Adenocarcinoma / metabolism. Ampulla of Vater / metabolism. Common Bile Duct Neoplasms / metabolism. HMGB Proteins / metabolism. Mucins / metabolism. Pancreatic Neoplasms / metabolism. Stomach Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Bile Ducts, Intrahepatic / metabolism. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / metabolism. Carcinoma, Pancreatic Ductal / pathology. Female. Humans. Intestinal Neoplasms / metabolism. Intestinal Neoplasms / pathology. Lymphatic Metastasis. Male. Middle Aged. Mucin 5AC. Neoplasm Invasiveness. SOXB1 Transcription Factors

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  • (PMID = 16596179.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / HMGB Proteins; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucins; 0 / SOX2 protein, human; 0 / SOXB1 Transcription Factors; 0 / Transcription Factors
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20. Shan Y, Zhao DB, Che X, Wang JX, Shao YF, Zhao P: [Clinical significance of solitary lymph node metastasis in carcinoma of the ampulla of Vater]. Zhonghua Zhong Liu Za Zhi; 2006 Sep;28(9):694-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical significance of solitary lymph node metastasis in carcinoma of the ampulla of Vater].
  • OBJECTIVE: To investigate the rule of distribution of solitary lymph node metastasis and its relation with clinico-pathologic factors in carcinoma of ampulla of Vater.
  • METHODS: The data of 26 patients who were discovered to have solitary lymph node metastasis, from 152 patients with carcinoma of the ampulla of Vater who had received pancreatoduodenectomy were retrospectively reviewed.
  • RESULTS: Of these 152 patients with carcinoma of ampulla of Vater, 47(30.
  • It was revealed by Chi-square test (chi(2) ) that solitary lymph node metastasis was correlated with the tumor size (P = 0.
  • Sentinel lymph node assessment may be helpful to determine the extent of lymph node dissection for carcinoma of the ampulla of Vater.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Pancreatic Neoplasms / pathology. Pancreaticoduodenectomy. Retrospective Studies. Sentinel Lymph Node Biopsy

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  • (PMID = 17274378.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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21. Tocay-Ajcuc H, Téllez-Avila FI, García-Martínez CI, Chávez-Tapia NC, Uscanga-Domínguez LF, Ramírez-Luna MA, Chan-Nuñez C, Ruíz-Cordero R, Torre-Delgadillo A: [Clinical characteristics associated to resectability in patients with tumors of the ampulla of Vater in a third-level hospital in Mexico: an 18-year experience]. Acta Gastroenterol Latinoam; 2010 Jun;40(2):147-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical characteristics associated to resectability in patients with tumors of the ampulla of Vater in a third-level hospital in Mexico: an 18-year experience].
  • [Transliterated title] Caracteristicas clínicas asociadas a resecabilidad en pacientes con tumores del ámpula de Vater en un hospital de tercer nivel en Mexico: experiencia de 18 años.
  • BACKGROUND: Ampulla of Vater's tumors (AVT) are rare and account for 0.2% of neoplasia in necropsies.
  • Adenocarcinoma was the most common histological type and 39% of cases were in stage IV at diagnosis.
  • CONCLUSION: The probability of surgical resection is lower in patients older than 65 years and higher in those with melena at the diagnosis.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Male. Mexico. Middle Aged. Neoplasm Staging. Patient Selection. Retrospective Studies

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  • (PMID = 20645563.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Argentina
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22. Nagano Y, Sekido H, Matsuoi K, Ohtsuki K, Gorai K, Kunisaki C, Ike H, Imada T, Shimada H: Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy. Hepatogastroenterology; 2005 May-Jun;52(63):933-5
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  • [Title] Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy.
  • Duodenoscopy was performed and showed the protruded lesion of the ampulla of Vater, biopsied specimens from this tumor revealed adenocarcinomas.
  • The problem in this case was that the rt middle colic artery (MCA), and the middle colic vein (MCV) tend to be injured because these vessels are situated near the caudal region of the pancreas.
  • Double cancer of the ampulla of Vater and the esophagus are extremely rare, with only 4 cases reported.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Gastrectomy. Gastric Stump / surgery. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy. Postoperative Complications / surgery
  • [MeSH-minor] Adenoma / surgery. Humans. Lymph Node Excision. Middle Aged. Neoplasm Invasiveness. Reoperation. Stomach Neoplasms / surgery

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  • (PMID = 15966235.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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23. Qiao QL, Zhao YG, Ye ML, Yang YM, Zhao JX, Huang YT, Wan YL: Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection. World J Surg; 2007 Jan;31(1):137-43; discussion 144-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection.
  • INTRODUCTION: The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms.
  • Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected.
  • The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected ampullary carcinoma.
  • METHODS: Clinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002.
  • Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).
  • Factors that significantly influenced survival were lymph node status (P < 0.001), depth of tumor infiltration (P = 0.029), and TNM stage (P < 0.001) on univariate analysis.
  • CONCLUSIONS: Carcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer.
  • Pancreaticoduodenectomy is the treatment of choice for this tumor.
  • Long-term survival was independently influenced by the depth of tumor infiltration and lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Hospital Mortality. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 17171495.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Kim ST, Lee J, Lee KT, Lee JK, Lee KH, Choi SH, Heo JS, Choi DW, Park SH, Park JO, Lim HY, Park YS, Kang WK: The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater. Med Oncol; 2010 Dec;27(4):1149-54
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  • [Title] The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater.
  • Adenocarcinoma arising from the ampulla of Vater is a rare neoplasm that accounts for only 0.2% of all gastrointestinal tract malignancies and has limited data regarding its frontline therapy.
  • We investigated the treatment outcomes in patients with advanced adenocarcinoma of the ampulla of Vater receiving frontline cisplatin-based combination chemotherapy.
  • We analyzed 29 patients with advanced adenocarcinoma of the ampulla of Vater who had been treated by frontline cisplatin-based combination chemotherapy between June 2003 and April 2008.
  • The cisplatin-based combination chemotherapy showed moderate activity and a favorable toxicity profile as a frontline treatment for patients with advanced adenocarcinoma of the ampulla of Vater.
  • [MeSH-major] Adenocarcinoma / drug therapy. Ampulla of Vater / drug effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy

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  • (PMID = 19898973.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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25. Baumhoer D, Riener MO, Zlobec I, Tornillo L, Vogetseder A, Kristiansen G, Dietmaier W, Hartmann A, Wuensch PH, Sessa F, Ruemmele P, Terracciano LM: Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater. Mod Pathol; 2009 Feb;22(2):306-13
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  • [Title] Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater.
  • We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater.
  • CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma.
  • [MeSH-major] Adenoma / chemistry. Ampulla of Vater / chemistry. Antigens, CD24 / analysis. Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma / chemistry. Common Bile Duct Neoplasms / chemistry. S100 Proteins / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Europe. Female. Humans. Male. Middle Aged. Mucous Membrane / chemistry. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19043399.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD24; 0 / Biomarkers, Tumor; 0 / CD24 protein, human; 0 / CDH3 protein, human; 0 / Cadherins; 0 / S100 Proteins; 142662-27-9 / S100A4 protein, human
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26. Selvakumar E, Rajendran S, Balachandar TG, Kannan DG, Jeswanth S, Ravichandran P, Surendran R: Neuroendocrine carcinoma of the ampulla of Vater: a clinicopathologic evaluation. Hepatobiliary Pancreat Dis Int; 2008 Aug;7(4):422-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendocrine carcinoma of the ampulla of Vater: a clinicopathologic evaluation.
  • BACKGROUND: Only 105 cases of neuroendocrine tumor (NET) of the ampulla of Vater have been described, mostly as single case reports.
  • This study was to determine the relative incidence and clinicopathological characteristics of high-grade neuroendocrine carcinoma (small cell carcinoma and large cell carcinoma) of the ampulla of Vater at a single institution.
  • METHODS: Sections from paraffin blocks of tumors of the ampulla of Vater taken from 45 patients who underwent Whipple's procedure and 6 patients who underwent palliative bypass between September 2003 and January 2007 were subjected to immunohistochemical analysis.
  • The clinical and pathological data from 5 patients diagnosed with NET of the ampulla of Vater were analyzed.
  • CONCLUSIONS: The relative incidence of high-grade neuroendocrine carcinomas of the ampulla of Vater is higher than that generally expected.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Large Cell. Carcinoma, Neuroendocrine. Carcinoma, Small Cell. Common Bile Duct Neoplasms
  • [MeSH-minor] Adult. Biliary Tract Surgical Procedures. Female. Humans. Incidence. Male. Middle Aged. Neoplasm Invasiveness. Palliative Care. Treatment Outcome

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  • (PMID = 18693180.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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27. Terasawa H, Uchiyama K, Tani M, Kawai M, Tsuji T, Tabuse K, Kobayashi Y, Taniguchi K, Yamaue H: Impact of lymph node metastasis on survival in patients with pathological T1 carcinoma of the ampulla of Vater. J Gastrointest Surg; 2006 Jun;10(6):823-8
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  • [Title] Impact of lymph node metastasis on survival in patients with pathological T1 carcinoma of the ampulla of Vater.
  • To determine the prognostic factors for patients with pathological T1 (pT1) carcinoma of the ampulla of Vater, 36 consecutive patients with carcinoma of the ampulla of Vater who underwent surgery were retrospectively analyzed in terms of clinicopathological features.
  • Factors favorably influencing a long-term outcome were the absence of lymph node metastasis (P < 0.0001), the absence of ulcer formation of the tumor (P = 0.0062), and the absence of tumor invasion into the duodenum (P = 0.0025) and the pancreas (P = 0.0098).
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Lymphatic Metastasis
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Female. Humans. Japan / epidemiology. Lymph Node Excision. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Prognosis. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 16769538.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Tang W, Inagaki Y, Kokudo N, Guo Q, Seyama Y, Nakata M, Imamura H, Sano K, Sugawara Y, Makuuchi M: KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression. World J Gastroenterol; 2005 Sep 21;11(35):5450-4
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  • [Title] KL-6 mucin expression in carcinoma of the ampulla of Vater: association with cancer progression.
  • AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.
  • METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection.
  • RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases.
  • Staining was not found in the surrounding non-cancer regions of the ampullary tissues.
  • CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Antigens / metabolism. Common Bile Duct Neoplasms / metabolism. Glycoproteins / metabolism. Mucins / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Antigens, Neoplasm. Female. Humans. Immunohistochemistry. Male. Middle Aged. Mucin-1

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  • (PMID = 16222735.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens; 0 / Antigens, Neoplasm; 0 / Glycoproteins; 0 / MUC1 protein, human; 0 / Mucin-1; 0 / Mucins
  • [Other-IDs] NLM/ PMC4320352
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29. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM: Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol; 2005 Mar;29(3):359-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2.
  • Pancreatobiliary and ampulla of Vater adenocarcinomas frequently metastasize to regional lymph nodes, liver, or lung and are difficult to diagnose because they lack specific immunohistochemical markers.
  • We studied the expression of cytokeratin 7 (CK7), cytokeratin 17 (CK17), cytokeratin 20 (CK20), CDX2, mucin 1 (MUC1), mucin 2 (MUC2), and mucin 5AC (MUC5AC) in 46 cases of pancreatic ductal carcinoma, 18 ampulla of Vater adenocarcinomas, and 24 intrahepatic cholangiocarcinomas.
  • The expression of MUC1 and CK17 was restricted to pancreatic ductal carcinoma (41 of 46, 89%; 38 of 46, 83%, respectively), the ampullary carcinoma of pancreatobiliary origin (6 of 6, 100%; 5 of 6, 83%, respectively), and intrahepatic cholangiocarcinoma (20 of 24, 83%; 17 of 24, 71%, respectively).
  • MUC2 was rarely expressed in pancreatic ductal carcinoma (1 of 46, 2%) and was negative in the ampullary carcinoma of pancreatobiliary origin and in intrahepatic cholangiocarcinoma.
  • A heterogeneous CDX2 staining pattern was seen in 1 of 6 cases of the ampullary carcinoma of pancreatobiliary origin (17%), 5 of 24 intrahepatic cholangiocarcinomas (21%), and 10 of 46 (22%) pancreatic ductal carcinomas.
  • MUC1+/CK17+ can be used as positive markers for pancreatic ductal carcinomas, the ampullary carcinoma of pancreatobiliary origin, and cholangiocarcinomas with positive predictive values of 76%, 83%, and 58%, respectively.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Carcinoma, Pancreatic Ductal / pathology. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Female. Homeodomain Proteins / metabolism. Humans. Immunohistochemistry. Keratins / metabolism. Male. Mucins / metabolism. Neoplasm Proteins / metabolism

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  • (PMID = 15725805.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / Mucins; 0 / Neoplasm Proteins; 68238-35-7 / Keratins
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30. Akatsu T, Aiura K, Takahashi S, Kameyama K, Kitajima M, Kitagawa Y: Signet-ring cell carcinoma of the ampulla of Vater: report of a case. Surg Today; 2007;37(12):1110-4
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  • [Title] Signet-ring cell carcinoma of the ampulla of Vater: report of a case.
  • Signet-ring cell carcinoma (SRCC) of the ampulla of Vater is uncommon, and only 13 cases have been previously described.
  • We herein report a rare case of a 43-year-old woman with SRCC in the ampulla of Vater.
  • She underwent a pancreaticoduodenectomy with an extended lymphadenectomy for ampullary carcinoma.
  • This neoplasm was classified as AcdbBi, 2.0 x 1.8 cm, ulcerative type, Panc(0), Du(2), T(2)N(0)M(-), Stage II according to the Japanese Classification on Cancer of the Biliary Tract.
  • Unfortunately, previous reports of ampullary SRCC have been limited to short-term follow-ups with a median period of only 12 months (range, 6-134 months), and long-term survival (more than 5 years) was only documented in two cases without lymph node metastasis (including the present case).
  • In conclusion, the experience gained in the present and previous cases suggests that long-term survival is possible following a curative resection in selected patients with ampullary SRCC without nodal involvement.
  • Due to the lack of sufficient evidence, additional reports are warranted to determine whether SRCC also portends a poor prognosis in patients with ampullary cancer.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Signet Ring Cell / pathology. Common Bile Duct Neoplasms / pathology. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans

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  • (PMID = 18030577.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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31. Sawaki A, Mizuno N, Hoki N, Ishikawa H, Takagi T, Yamao K: [Effect of S-1 in a patient with post-operative recurrence of carcinoma of the ampulla of Vater]. Gan To Kagaku Ryoho; 2007 Dec;34(13):2301-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect of S-1 in a patient with post-operative recurrence of carcinoma of the ampulla of Vater].
  • We report a case of recurrent carcinoma of the ampulla of Vater with multiple lung and abdominal lymph node metastases that well responded to S-1, an oral fluoropyrimidine.
  • A 56-years-old woman underwent a pylorus-preserving pancreaticoduodenectomy for carcinoma of the ampulla of Vater in October 2003.
  • Anti-tumor efficacy was confirmed to be partial response by Response Evaluation Criteria in Solid Tumors (RECIST).
  • S-1 might be an effective and safe agent for carcinoma of the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Antimetabolites, Antineoplastic / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / surgery. Oxonic Acid / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Drug Combinations. Female. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local. Pancreaticoduodenectomy

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  • (PMID = 18079635.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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32. Wu TC, Shao YF, Shan Y, Wu JX, Zhao DB, Xu LB, Zhao P: [Prognostic implication of common bile duct infiltration in adenocarcinoma of the ampulla of Vater after pancreaticoduodenectomy]. Zhonghua Zhong Liu Za Zhi; 2008 Oct;30(10):775-8
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  • [Title] [Prognostic implication of common bile duct infiltration in adenocarcinoma of the ampulla of Vater after pancreaticoduodenectomy].
  • OBJECTIVE: To investigate the prognostic implication of common bile duct infiltration in the adenocarcinoma of the ampulla of Vater after panreaticoduodenectomy.
  • METHODS: A retrospective study was conducted on clinical manifestation, pathological behavior and survival data in 102 patients with Vater's ampulla adenocarcinoma, who underwent pancreaticoduodenectomy from Jan 1980 to Dec 2003.
  • CONCLUSION: If the adenocarcinoma of the Vater's ampulla infiltrated the common bile duct, the invasion to the pancreatic medulla is likely developed, and usually with a poor non-recurrence and overall survival.
  • [MeSH-major] Adenocarcinoma. Ampulla of Vater. Common Bile Duct / pathology. Common Bile Duct Neoplasms. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Retrospective Studies. Survival Rate

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  • (PMID = 19173811.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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33. Falconi M, Crippa S, Domínguez I, Barugola G, Capelli P, Marcucci S, Beghelli S, Scarpa A, Bassi C, Pederzoli P: Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma. Ann Surg Oncol; 2008 Nov;15(11):3178-86

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic relevance of lymph node ratio and number of resected nodes after curative resection of ampulla of Vater carcinoma.
  • BACKGROUND: Nodal metastasis is considered a major prognostic factor in patients with ampulla of Vater carcinoma (AVC).
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Lymph Nodes / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Cohort Studies. Duodenal Neoplasms / pathology. Duodenal Neoplasms / secondary. Duodenal Neoplasms / surgery. Female. Follow-Up Studies. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / secondary. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Prognosis. Prospective Studies. Survival Rate

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  • (PMID = 18712568.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Fujita T, Konishi M, Gotohda N, Takahashi S, Nakagohri T, Kojima M, Kinoshita T: Invasive micropapillary carcinoma of the ampulla of Vater with extensive lymph node metastasis: Report of a case. Surg Today; 2010 Dec;40(12):1197-200

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive micropapillary carcinoma of the ampulla of Vater with extensive lymph node metastasis: Report of a case.
  • We report a case of invasive micropapillary carcinoma of the papilla of Vater.
  • Detailed investigations revealed a tumor in the periampullary region, and pancreatoduodenectomy was performed for cancer of the ampulla of Vater.
  • Microscopic examination of the resected specimen revealed a tumor composed mainly of carcinoma cells arranged in micropapillary structures, with extensive regional lymph node metastasis.
  • Tumor recurrence with progressive ascites and hydronephrosis was found 8 months after surgery, and the patient died of the disease 20 months after surgery.
  • [MeSH-major] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Fatal Outcome. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 21110170.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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35. Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW: Neuroendocrine tumors of the ampulla of Vater: biological behavior and surgical management. Arch Surg; 2009 Jun;144(6):527-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuroendocrine tumors of the ampulla of Vater: biological behavior and surgical management.
  • OBJECTIVES: To describe the biological behavior and surgical management of ampullary neuroendocrine tumors in 7 patients.
  • PATIENTS: Seven patients with ampullary neuroendocrine tumors.
  • Even when the tumor expressed gastrin, vasoactive intestinal peptide, or somatostatin, no patient had a hypersecretion syndrome.
  • One patient with a high-grade malignant neoplasm died after 15 months.
  • Two patients had transduodenal local resections, one for a 1.1-cm paraganglioma (disease-free, 11 years) and the other for a 0.6-cm carcinoid tumor (disease-free, 7 months).
  • CONCLUSIONS: This is one of the largest series of neuroendocrine tumors of the ampulla.
  • Unlike duodenal carcinoid tumors, hypersecretion syndromes were absent and small tumor size did not preclude locoregional metastases.
  • Tumor grade predicted survival.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / surgery

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  • (PMID = 19528385.001).
  • [ISSN] 1538-3644
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Hamada Y, Nakayama Y, Mizoguchi M, Ikeda S, Kuroki M, Iwasaki H: MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection. Cancer Lett; 2006 Nov 18;243(2):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MK-1 expression in carcinoma of the ampulla of Vater as a predictor of improved prognosis after surgical resection.
  • This retrospective study investigated the prognostic significance of MK-1 expression in human carcinoma of the ampulla of Vater (CAV).
  • [MeSH-major] Antigens, Neoplasm / biosynthesis. Cell Adhesion Molecules / biosynthesis. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Ampulla of Vater. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Carcinoma, Small Cell / metabolism. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / surgery. Female. Humans. Immunohistochemistry / statistics & numerical data. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Prognosis. Proportional Hazards Models

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  • (PMID = 16616808.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human
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37. Liu N, Liang H, Zhang RP, Pan Y, Liu Y, Deng JY, Wang XN, Ding XW, Hao XS: [Number of lymph node metastases: a significant prognostic factor for patients with radical resection of carcinoma of the ampulla of Vater]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Jul;10(4):350-2
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  • [Title] [Number of lymph node metastases: a significant prognostic factor for patients with radical resection of carcinoma of the ampulla of Vater].
  • OBJECTIVE: To identify prognostic factors predicting survival after radical resection of ampullary carcinoma.
  • METHODS: Clinical data of sixty- five patients with cancer of the ampulla of Vater underwent pancreaticoduodenectomy and regional lymphadenectomy were analyzed retrospectively.
  • CONCLUSION: The number of positive regional lymph nodes is an independent prognostic factor in patients with ampullary carcinoma after resection.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / diagnosis. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma / pathology. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Postoperative Period. Prognosis. Retrospective Studies

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  • (PMID = 17659460.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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38. Nassar H, Albores-Saavedra J, Klimstra DS: High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol; 2005 May;29(5):588-94
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  • [Title] High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.
  • We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of lung tumors into small cell carcinoma (SCC, 6 cases) and large cell neuroendocrine carcinoma (LCNEC, 8 cases) types.
  • The immunohistochemical findings were compared with those of 13 cases of primary poorly differentiated ampullary adenocarcinomas (PDACA) lacking neuroendocrine morphology.
  • The mean tumor size was 2.5 cm.
  • Overall, 64% of patients with ampullary HGNEC died of disease (mean follow-up, 14.5 months).
  • In conclusion, HGNECs of the ampulla are rare (2%-3% of ampullary tumors in our material).
  • The clinical course parallels that of their pulmonary counterparts and appears to be worse than that of locally advanced ampullary adenocarcinomas.
  • Loss of Rb expression, a characteristic finding in pulmonary SCCs, is present in almost half of ampullary HGNECs.
  • Thus, there are differences in the molecular phenotypes of these two types of ampullary carcinoma, supporting the distinction of poorly differentiated carcinomas with a neuroendocrine phenotype from those without.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Survival Rate

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  • (PMID = 15832081.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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39. Lee JH, Lee KG, Ryou H, Jun YJ, Paik SS, Park HK, Lee KS: Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma. Hepatogastroenterology; 2010 May-Jun;57(99-100):646-52

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma.
  • The influences of histologic type and perineural invasion on recurrence and survival in ampullar of Vater carcinoma still need to be assessed.
  • METHODOLOGY: We reviewed and analyzed the clinicopathologic data, surgical outcomes, recurrence and survival of 49 patients who received curative pancreatoduodenectomy for ampulla of Vater carcinoma at Hanyang University Hospital between July 1994 and June 2008.
  • Perineural invasion as well as tumor grade, T stage, lymph node metastasis, and lymphatic invasion were associated with survival (p < 0.05).
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Peripheral Nerves / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • (PMID = 20698243.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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40. Shiba H, Misawa T, Wakiyama S, Iida T, Ishida Y, Yanaga K: Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case. J Gastrointest Cancer; 2010 Jun;41(2):138-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pedunculated early ampullary carcinoma treated by ampullectomy: report of a case.
  • CASE REPORT: A 30-year-old woman was admitted to our hospital for treatment of an ampullary tumor.
  • Upper gastrointestinal endoscopy revealed a pedunculated tumor in the ampulla of Vater with a diameter of 50 mm, which was biopsied and diagnosed as tubulovillous adenoma with moderate atypia.
  • Endoscopic ultrasonography demonstrated a hypoechoic tumor limited to the mucosa and without evidence of lymph node metastasis.
  • DISCUSSION: Ampullectomy is an established method for ampullary tumor, but such a tumor with a long stalk is rare.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 20012229.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW: Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg; 2008 Aug;207(2):210-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumors of the ampulla of vater: histopathologic classification and predictors of survival.
  • BACKGROUND: The histology and clinical behavior of ampullary tumors vary substantially.
  • We speculated that this might reflect the presence of two kinds of ampullary adenocarcinoma: pancreaticobiliary and intestinal.
  • STUDY DESIGN: We analyzed patient demographics, presentation, survival (mean followup 44 months), and tumor histology for 157 consecutive ampullary tumors resected from 1989 to 2006.
  • Size of tumor did not predict survival, nor did cribriform/papillary features, dirty necrosis, apical mucin, or nuclear atypia.
  • Patients with pancreaticobiliary ampullary adenocarcinomas presented with jaundice more often than those with the intestinal kind (p = 0.01) and had worse survival.
  • CONCLUSIONS: In addition to other factors, tumor type (intestinal versus pancreaticobiliary) had a major effect on survival in patients with ampullary adenocarcinoma.
  • The current concept of ampullary adenocarcinoma as a unique entity, distinct from duodenal and pancreatic adenocarcinoma, might be wrong.
  • Intestinal ampullary adenocarcinomas behaved like their duodenal counterparts, but pancreaticobiliary ones were more aggressive and behaved like pancreatic adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Follow-Up Studies. Humans. Jaundice, Obstructive / mortality. Jaundice, Obstructive / pathology. Jaundice, Obstructive / surgery. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Risk Factors

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  • (PMID = 18656049.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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42. Lowe MC, Coban I, Adsay NV, Sarmiento JM, Chu CK, Staley CA, Galloway JR, Kooby DA: Important prognostic factors in adenocarcinoma of the ampulla of Vater. Am Surg; 2009 Sep;75(9):754-60; discussion 761
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Important prognostic factors in adenocarcinoma of the ampulla of Vater.
  • Ampullary adenocarcinoma (AmpCA) carries a better overall survival (OS) rate than other periampullary cancers.
  • Mean age was 61.3 +/- 12.2 years, mean tumor size was 2.6 +/- 1.3 cm, 57 per cent were > or = T3 tumors, 42 per cent were N1 stage, 13 (49%) had perineural invasion (PNI), and 29 (64%) had lymphovascular invasion (LVI).
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Georgia / epidemiology. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Factors. Survival Rate / trends. Time Factors

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  • (PMID = 19774945.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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43. Sakorafas GH, Giannopoulos GA, Parasi A, Konstantoudakis G, Tzanakis N, Stergiopoulos S, Peros G: Large somatostatin-producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease. Case report and review of the literature. JOP; 2008;9(5):633-9
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  • [Title] Large somatostatin-producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease. Case report and review of the literature.
  • CASE REPORT: We present the case of a 49-year-old female patient with von Recklinghausen's disease and an incidentally diagnosed ampullary neoplasm.
  • Histology and immunohistochemistry showed that the duodenal tumor was an ampullary somatostatin-producing endocrine carcinoma while the gastric tumor was a gastrointestinal stromal tumor (GIST).
  • The postoperative course was uneventful and the patient is alive, without tumor recurrence, six years after surgery.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Neurofibromatosis 1 / complications. Somatostatinoma / complications
  • [MeSH-minor] Female. Humans. Middle Aged. Somatostatin / secretion. Tumor Burden

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  • (PMID = 18762695.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
  • [Number-of-references] 28
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44. Pamukcuoglu M, Oksuzoglu B, Abali H, Akoglu M, Atalay F, Budakoglu B, Uncu D, Ozdemir NY, Guler T, Zengin N: Prognostic factors and clinicopathological characteristics of carcinoma of ampulla Vateri. Int Surg; 2008 Jul-Aug;93(4):214-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and clinicopathological characteristics of carcinoma of ampulla Vateri.
  • The aim of this study was to describe the clinicopathological characteristics and prognostic factors of carcinoma of ampulla Vateri.
  • ECOG performance status (P = 0.06), stage (P = 0.05), perineural invasion (P = 0.01), tumor grade (P = 0.01), and treatment with chemotherapy, chemoradiotherapy, or only radiotherapy (P = 0.001) had a statistically significant impact on overall survival, whereas only tumor histopathology (P < 0.001) was shown to have a statistically significant effect on disease-free survival.
  • Carcinoma of ampulla Vateri is a rare gastrointestinal tumor.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 19731856.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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45. Hirono S, Tani M, Terasawa H, Kawai M, Ina S, Uchiyama K, Nakamura Y, Kakudo K, Yamaue H: A collision tumor composed of cancers of the bile duct and ampulla of Vater--immunohistochemical analysis of a rare entity of double cancer. Hepatogastroenterology; 2008 May-Jun;55(84):861-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A collision tumor composed of cancers of the bile duct and ampulla of Vater--immunohistochemical analysis of a rare entity of double cancer.
  • Collision cancer of the bile duct and the papilla of Vater is an extremely rare entity.
  • Computed tomography showed isodensity masses in the middle bile duct and the papilla of Vater.
  • Gastroduodenal endoscopy showed a tumor with ulceration at the papilla of Vater.
  • The patient was diagnosed with cancers of the middle bile duct and the papilla of Vater, and a pylorus-preserving pancreatoduodenectomy was performed.
  • On pathological examination, the tumor in the middle bile duct showed a well differentiated carcinoma that had spread to the proximal bile duct, whereas the tumor in the papilla of Vater showed a papillo-tubular carcinoma with a marked production of mucin, suggesting an intestinal type of ampullary cancer.
  • As a result, it was concluded that this was a case of collision cancer of the middle bile duct and the papilla of Vater.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Papillary / pathology. Ampulla of Vater / pathology. Biomarkers, Tumor / analysis. Common Bile Duct Neoplasms / pathology. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct / pathology. Diagnosis, Differential. Duodenum / pathology. Humans. Male. Neoplasm Invasiveness. Neoplasm Staging. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 18705284.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Hwang S, Lee SG, Lee YJ, Han DJ, Kim SC, Kwon SH, Ryu JH, Park JI, Lee HJ, Choi GW, Yu ES: Radical surgical resection for carcinoid tumors of the ampulla. J Gastrointest Surg; 2008 Apr;12(4):713-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radical surgical resection for carcinoid tumors of the ampulla.
  • Ampullary carcinoid tumors are extremely rare.
  • The present study describes the clinicopathological features and outcomes for 10 ampullary carcinoid patients who underwent radical resection from 1998 to 2005.
  • During this study period, 294 patients underwent pancreatoduodenectomy for ampullary neoplasms in our institution.
  • The mean tumor size and volume were 2.1 +/- 1.3 cm and 4.1 +/- 6.9 ml, respectively.
  • Univariate analyses revealed that a maximal tumor diameter > or =2 cm and tumor extension beyond the ampulla were risk factors for tumor recurrence.
  • In conclusion, while the majority of ampullary carcinoids are indolent, this tumor is associated with a relatively poor prognosis.
  • We believe that radical resection, with the aim of complete tumor removal and cure, is the treatment of choice.
  • [MeSH-major] Ampulla of Vater. Carcinoid Tumor / surgery. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Chromogranins / analysis. Female. Histocytochemistry. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Recurrence, Local. Pancreaticoduodenectomy. Prognosis. Risk Factors. Survival Rate. Synaptophysin / analysis

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  • (PMID = 17992565.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromogranins; 0 / Synaptophysin
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47. Barauskas G, Gulbinas A, Pundzius J: Results of surgical treatment of carcinoma of papilla of Vater. Medicina (Kaunas); 2007;43(6):455-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Results of surgical treatment of carcinoma of papilla of Vater.
  • Adenocarcinoma is the most common malignant tumor of the ampulla, but in general, it is still rare.
  • To evaluate immediate postoperative and long-term results, we have collected data prospectively in a specially created database on 21 consecutive patients with adenocarcinoma of the papilla of Vater, operated on at the Department of Surgery, Kaunas University of Medicine Hospital.
  • Pancreas-associated morbidity was 14.3% in the series.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Data Interpretation, Statistical. Female. Follow-Up Studies. Humans. Kaplan-Meier Estimate. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Prospective Studies. Sex Factors. Time Factors. Treatment Outcome

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  • (PMID = 17637516.001).
  • [ISSN] 1648-9144
  • [Journal-full-title] Medicina (Kaunas, Lithuania)
  • [ISO-abbreviation] Medicina (Kaunas)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Lithuania
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48. Ohike N, Kim GE, Tajiri T, Krasinskas A, Basturk O, Coban I, Bandyopadhyay S, Morohoshi T, Goodman M, Kooby DA, Sarmiento JM, Adsay NV: Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases. Am J Surg Pathol; 2010 Dec;34(12):1731-48
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  • [Title] Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases.
  • BACKGROUND: There has been no uniform terminology for systematic analysis of mass-forming preinvasive neoplasms (which we term tumoral intraepithelial neoplasia) that occur specifically within the ampulla.
  • Here, we provide a detailed analysis of these neoplasms, which we propose to refer to as intra-ampullary papillary-tubular neoplasm (IAPN).
  • MATERIALS AND METHODS: Three hundred and seventeen glandular neoplasms involving the ampulla were identified through a review of 1469 pancreatoduodenectomies and 11 ampullectomies.
  • Eighty-two neoplasms characterized by substantial preinvasive exophytic component that grew almost exclusively (>75%) within the ampulla (in the ampullary channel or intra-ampullary portions of the very distal segments of the common bile duct or pancreatic duct) were analyzed. RESULTS:.
  • (1) Clinical: The mean age was 64 years, male/female ratio was 2.4, and mean tumor size was 2.7 cm. (2) Pathology: The tumors had a mixture of both papillary and tubular growth (each constituting at least 25% of the lesion) in 57%; predominantly (>75%) papillary in 23%, and predominantly (>75%) tubular in 20%.
  • Size of the tumor and amount of dysplasia correlated with the incidence of invasion.
  • When compared with 166 conventional invasive carcinomas of the ampullary region, invasive IAPNs had significantly better prognosis with a mean survival of 51 versus 31 months (P<0.001) and the 3-year survival of 69% versus 44% (P<0.01).
  • CONCLUSIONS: Tumoral intraepithelial neoplasia occurring within the ampulla are highly analogous to pancreatic or biliary intraductal papillary and tubular neoplasms as evidenced by their papillary and/or tubular growth, variable cell lineage, and spectrum of dysplastic change (adenoma-carcinoma sequence), and thus we propose to refer to these as IAPN.
  • IAPNs are biologically indolent; noninvasive examples show an excellent prognosis, whereas those with invasion exhibit a malignant but nevertheless significantly better prognosis than typical invasive ampullary carcinomas unaccompanied by IAPNs.
  • Twenty eight percent (64 of 230) of invasive carcinomas within the ampulla arise in association with IAPNs.

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  • (PMID = 21084962.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P20 CA101936; United States / NCI NIH HHS / CA / P50 CA062924; United States / NCI NIH HHS / CA / P50 CA062924-18; United States / NCI NIH HHS / CA / CA101936
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ NIHMS315774; NLM/ PMC3168573
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49. Guercioni G, Marmorale C, Siquini W, Fianchini M, Fianchini A, Landi E: Incidental small ampullary somatostatinoma treated with ampullectomy 2 years after diagnosis. Dig Dis Sci; 2006 Oct;51(10):1767-72
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  • [Title] Incidental small ampullary somatostatinoma treated with ampullectomy 2 years after diagnosis.
  • Somatostatinomas are rare tumors; ampullary somatostatinomas are very rare.
  • We report a case of a small pure somatostatin-producing neuroendocrine tumor of ampulla of Vater in a 54-year-old woman with neither neurofibromatosis nor somatostatinoma syndrome, "incidentally" discovered during an abdominal computed tomography.
  • The size of the tumor (1.5 cm) and the other radiologic findings had not changed since the abdominal CT scan 2 years before.
  • ERCP-obtained biopsies revealed a neuroendocrine tumor with psammoma bodies; immunohistochemical profile was positive for chromogranin and somatostatin.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Somatostatinoma / surgery

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  • (PMID = 16967313.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Woo SM, Ryu JK, Lee SH, Lee WJ, Hwang JH, Yoo JW, Park JK, Kang GH, Kim YT, Yoon YB: Feasibility of endoscopic papillectomy in early stage ampulla of Vater cancer. J Gastroenterol Hepatol; 2009 Jan;24(1):120-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Feasibility of endoscopic papillectomy in early stage ampulla of Vater cancer.
  • BACKGROUND AND AIM: Although endoscopic papillectomy has been attempted in early stage ampullary cancer (pTis, T1), its curative role and indications remain uncertain.
  • METHODS: We performed a retrospective analysis of clinical and histopathological data of 216 patients with ampullary cancer between 1991 and 2006.
  • RESULTS: No tumor in pTis stage had metastasized to lymph nodes and only 9% of tumors in pT1 had metastasized.
  • Tumor size (P = 0.018), depth of invasion (P = 0.021) and venous invasion (P = 0.014) were found to be significantly related to lymph node metastasis.
  • Cases with early stage ampullary cancer of less than 2 cm with a well-differentiated histology and no angiolymphatic invasion (n = 13) showed no lymph node metastasis and no recurrence during a median follow up of 35.9 months.
  • CONCLUSION: Endoscopic papillectomy can be adopted as a viable alternative to surgery in patients with early stage ampullary cancer of less than 2 cm in size and with a well-differentiated histology.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Digestive System
  • [MeSH-minor] Cell Differentiation. Feasibility Studies. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis. Neoplasm Invasiveness. Neoplasm Staging. Patient Selection. Proportional Hazards Models. Recurrence. Retrospective Studies. Risk Assessment. Time Factors. Treatment Outcome

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  • (PMID = 19032444.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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51. Krishnan S, Rana V, Evans DB, Varadhachary G, Das P, Bhatia S, Delclos ME, Janjan NA, Wolff RA, Crane CH, Pisters PW: Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater. Int J Radiat Oncol Biol Phys; 2008 Mar 1;70(3):735-43
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  • [Title] Role of adjuvant chemoradiation therapy in adenocarcinomas of the ampulla of vater.
  • PURPOSE: The role of adjuvant chemoradiation therapy (CRT) in the treatment of ampullary cancers remains undefined.
  • METHODS AND MATERIALS: Between May 1990 and January 2006, 54 of 96 patients with ampullary adenocarcinoma who underwent potentially curative pancreaticoduodenectomy also received adjuvant CRT.
  • On univariate analysis, age, gender, race/ethnicity, tumor grade, use of adjuvant treatment, and sequencing of adjuvant therapy were not significantly associated with LC, DC, or OS.
  • However, on univariate analysis, T3/T4 tumor stage was prognostic for poorer LC and OS (p = 0.02 and p < 0.001, respectively); node-positive disease was prognostic for poorer LC (p = 0.03).
  • On multivariate analysis, T3/T4 tumor stage was independently prognostic for decreased OS (p = 0.002).
  • CONCLUSIONS: Ampullary cancers have a distinctly better treatment outcome than pancreatic adenocarcinomas.
  • Higher primary tumor stage (T3/T4), an independent adverse risk factor for poorer treatment outcomes, may warrant the addition of adjuvant CRT to pancreaticoduodenectomy.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / radiotherapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Capecitabine. Chemotherapy, Adjuvant. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Female. Fluorouracil / administration & dosage. Fluorouracil / analogs & derivatives. Humans. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Prognosis. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 17980502.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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52. Moriya T, Kimura W, Hirai I, Mizutani M, Yamamoto T, Toya R, Kamiga M, Fuse A: Twelve years survival with repeated hepatectomy and lung resection for metastasis from carcinoma of the papilla of Vater after pancreaticoduodenectomy. Hepatogastroenterology; 2007 Sep;54(78):1652-4
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  • [Title] Twelve years survival with repeated hepatectomy and lung resection for metastasis from carcinoma of the papilla of Vater after pancreaticoduodenectomy.
  • We present a 60-year-old woman who underwent three times hepatectomy and lung resection for metastasis originating from a carcinoma of the papilla of Vater after pancreaticoduodenectomy with lymphadenectomy during 12 years.
  • Pancreaticoduodenectomy was performed in 1980 and histological examination of original tumor revealed a stage IIA papillary adenocarcinoma (pT3, pN0, pM0).
  • The current case is very rare, however, if patients with carcinoma of the papilla of Vater have localized liver metastases and no local recurrence, liver metastases should be resected to improve the chances for long-term survival.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma / surgery. Carcinoma / therapy. Common Bile Duct Neoplasms / surgery. Common Bile Duct Neoplasms / therapy. Hepatectomy / methods. Lung / surgery. Lung Neoplasms / secondary. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adenocarcinoma, Papillary / surgery. Female. Humans. Middle Aged. Neoplasm Metastasis. Time Factors. Treatment Outcome

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  • (PMID = 18019686.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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53. Kwon J, Lee SE, Kang MJ, Jang JY, Kim SW: A case of gangliocytic paraganglioma in the ampulla of Vater. World J Surg Oncol; 2010;8:42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of gangliocytic paraganglioma in the ampulla of Vater.
  • BACKGROUND: Duodenal gangliocytic paraganglioma is an extremely rare tumor and few cases have been reported to date.
  • CASE PRESENTATION: The authors report a case of gangliocytic paraganglioma verified by post-op pathology after pancreaticoduodenectomy for a tumor in the ampulla of Vater.
  • The patient was diagnosed to have a tumor in the ampulla of Vater with bleeding on its surface.
  • CONCLUSION: This tumor has precise clinical implications, and if continuous follow up is conducted after careful diagnosis and surgical treatment, invasive major operations, such as, radical pancreaticoduodenectomy can be avoided.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Paraganglioma / pathology

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  • (PMID = 20497533.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Other-IDs] NLM/ PMC2887868
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54. Bucher P, Chassot G, Durmishi Y, Ris F, Morel P: Long-term results of surgical treatment of Vater's ampulla neoplasms. Hepatogastroenterology; 2007 Jun;54(76):1239-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term results of surgical treatment of Vater's ampulla neoplasms.
  • BACKGROUND/AIMS: Vater's ampulla neoplasms account for 30% of resected bilio-pancreatic confluent tumors.
  • Study aim was to review long-term results of surgical treatment for ampullary neoplasms.
  • METHODOLOGY: A retrospective review from 1993 to 2002 identified 55 patients admitted for Vater's ampulla neoplasm in our institution.
  • RESULTS: Among the ampullary neoplasms, 10 were adenomas (median age 71) and 45 adenocarcinomas (median age 69).
  • The resectability rate of ampullary carcinomas was 84%.
  • CONCLUSIONS: Pancreatoduodenectomy remains the gold standard for Vater's ampulla neoplasms resection due to the low sensitivity of diagnostic biopsies for carcinoma detection.
  • Vater's ampulla neoplasms resection by pancreatoduodenectomy is associated with good long-term results; however survival after curative resection is influenced by lymph node status.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy

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  • (PMID = 17629078.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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55. Inagaki M, Obara M, Suzuki S, Ishizaki A, Takahashi K, Matsumoto K, Haneda M, Tokusashi Y, Miyokawa N, Kasai S: Mucinous carcinoma of Vater's ampulla with a unique extension along the main pancreatic duct. J Hepatobiliary Pancreat Surg; 2007;14(5):518-21
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  • [Title] Mucinous carcinoma of Vater's ampulla with a unique extension along the main pancreatic duct.
  • We report a case of mucinous carcinoma of Vater's ampulla with a unique extension along only the main pancreatic duct (MPD) and microinvasion to the pancreas.
  • Abdominal computed tomography (CT) demonstrated swelling in the head of the pancreas with a mass in the duodenum.
  • Hypotonic duodenography and endoscopic examination revealed a well-defined mass, measuring about 25 mm in size, in Vater's ampulla.
  • A biopsy specimen of the tumor showed moderately differentiated adenocarcinoma.
  • A pylorus-preserving pancreaticoduodenectomy with a regional lymphadenectomy was performed, under a preoperative diagnosis of adenocarcinoma of Vater's ampulla with direct invasion into the head of the pancreas.
  • The resected specimen of the duodenum confirmed the presence of the mass, which measured 22 x 15 mm in size, in Vater's ampulla.
  • Microscopically, the tumor consisted of two components: moderately differentiated adenocarcinoma in the peripheral region of the tumor Vater's papilla and mucinous carcinoma in the central region of the tumor.
  • The mucinous carcinoma component uniquely extended along only the MPD with microinvasion to the pancreas.
  • Immunohistochemically, both the moderately differentiated adenocarcinoma and the mucinous carcinoma were positive for cytokeratin 20 (CK20) and negative for cytokeratin 7 (CK7) which is the pattern of intestinal-type carcinoma of Vater's ampulla.
  • We concluded that the original site of this tumor may have been the duodenal epithelium of Vater's ampulla originally moderately differentiated adenocarcinoma-which subsequently changed to mucinous carcinoma that extended along only the MPD with microinvasion to the pancreas.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Humans. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 17909724.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Bogoevski D, Chayeb H, Cataldegirmen G, Schurr PG, Kaifi JT, Mann O, Yekebas EF, Izbicki JR: Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy. J Gastrointest Surg; 2008 Nov;12(11):1830-7; discussion 1837-8
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  • [Title] Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy.
  • BACKGROUND: To assess the prognostic significance of nodal microinvolvement in patients with carcinoma of the papilla of Vater.
  • The vast majority of patients were operated upon pancreatic ductal adenocarcinoma (n = 566, 73%), followed by carcinomas of the papilla of Vater (n = 112, 14%), pancreatic neuroendocrine carcinomas (n = 39, 5%), intraductal papillary mucinous neoplasms (n = 33, 4%), and distal bile duct carcinomas (n = 27, 3%).
  • Fresh-frozen tissue sections from 169 lymph nodes (LNs) classified as tumor free by routine histopathology from 57 patients with R0 resected carcinoma of the papilla of Vater who had been spared from adjuvant chemotherapy were immunohistochemically (IHC) examined, using a sensitive IHC assay with the anti-epithelial monoclonal antibody Ber-EP4 for tumor cell detection.
  • RESULTS: Of the 169 "tumor-free" LNs, 91 LNs (53.8%) contained Ber-EP4-positive tumor cells.
  • CONCLUSIONS: The influence of occult tumor cell dissemination in LNs of patients with histologically proven carcinoma of the papilla of Vater supports the need for further tumor staging through immunohistochemistry.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Chemotherapy, Adjuvant. Cohort Studies. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Probability. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Analysis. Treatment Outcome

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  • (PMID = 18791769.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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57. Prenzel KL, Warnecke-Eberz U, Brabender J, Baldus SE, Bollschweiler E, Gutschow CA, Drebber U, Hoelscher AH, Schneider PM: Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater. World J Gastroenterol; 2006 Jan 21;12(3):437-42
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  • [Title] Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater.
  • AIM: We examined quantitative mRNA expression of growth factor receptors (c-erbB-1, c-erbB-2) and the anti-apoptosis gene survivin known to be regulated in pancreatic adenocarcinomas and compared the expression pattern with that in carcinomas of the papilla of Vater.
  • METHODS: Quantitative real-time reverse transcriptase-PCR (QRT-PCR, Taqman) was performed to analyze mRNA expression levels of c-erbB-1, c-erbB-2 and survivin in normal and corresponding tumor samples of 31 pancreatic adenocarcinomas and 8 cancers of the papilla of Vater.
  • RESULTS: The overall median mRNA expression of survivin was significantly increased in both adenocarcinoma of the pancreas (P<0.01) and papilla of Vater (P<0.008) compared with uninvolved normal control tissue.
  • In pancreatic cancer, expression of c-erbB-1 was significantly decreased compared with the normal pancreatic tissue (P<0.03), whereas in the cancer of the papilla of Vater expression of c-erbB-2 was significantly downregulated (P<0.05) compared with the paired normal samples.
  • Gene expression was not associated with tumor stage, differentiation or prognosis.
  • CONCLUSION: The common anti-apoptosis gene survivin is overexpressed both in the cancer of the papilla of Vater and pancreas.
  • In contrast, the growth factor receptor genes c-erbB-1 and c-erbB-2 are differentially regulated in both tumor entities adding further evidence that pancreatic cancer is biologically different from the cancer of papilla of Vater.
  • [MeSH-major] Adenocarcinoma / metabolism. Ampulla of Vater. Common Bile Duct Neoplasms / metabolism. Pancreatic Neoplasms / metabolism. RNA, Messenger / genetics. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Inhibitor of Apoptosis Proteins. Male. Microtubule-Associated Proteins / genetics. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Retrospective Studies. Survival Rate

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  • (PMID = 16489645.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ PMC4066064
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58. Yamada S, Fujii T, Sugimoto H, Takeda S, Inoue S, Nomoto S, Kanazumi N, Nakao A: A proposal of an appropriate surgical approach for cancer of the ampulla of Vater: retrospective analysis of 73 resected cases. Hepatogastroenterology; 2007 Jan-Feb;54(73):10-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A proposal of an appropriate surgical approach for cancer of the ampulla of Vater: retrospective analysis of 73 resected cases.
  • BACKGROUND/AIMS: Because early ampullary cancer has a good prognosis, less invasive surgery should be considered.
  • METHODOLOGY: Between April 1975 and March 2005, seventy-three patients with ampullary cancer were treated.
  • If the tumor is preoperatively diagnosed as Panc(-), Du(-) and N(-), less invasive surgery may be indicated.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Humans. Lymphatic Metastasis. Neoplasm Invasiveness. Prognosis. Retrospective Studies. Survival Analysis

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  • (PMID = 17419221.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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59. Ruemmele P, Dietmaier W, Terracciano L, Tornillo L, Bataille F, Kaiser A, Wuensch PH, Heinmoeller E, Homayounfar K, Luettges J, Kloeppel G, Sessa F, Edmonston TB, Schneider-Stock R, Klinkhammer-Schalke M, Pauer A, Schick S, Hofstaedter F, Baumhoer D, Hartmann A: Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions. Am J Surg Pathol; 2009 May;33(5):691-704
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  • [Title] Histopathologic features and microsatellite instability of cancers of the papilla of vater and their precursor lesions.
  • The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of the papilla of Vater and their precursor lesions are not well established.
  • We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of MMR proteins and specific histopathologic features.
  • MSI-H cancers were significantly associated with intestinal mucinous subtype (P<0.001), high tumor grade (P=0.003), expansive growth pattern (P=0.044), and marked lymphoid host response (P=0.004).
  • The MMR deficient molecular pathway of carcinogenesis is associated with a histopathologic phenotype in ampullary cancer, similar to the one that has been well described in colon cancer.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater / pathology. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology. DNA Mismatch Repair. Gene Expression Regulation, Neoplastic. Microsatellite Instability. Precancerous Conditions / pathology
  • [MeSH-minor] Adaptor Proteins, Signal Transducing / genetics. Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adenocarcinoma, Mucinous / genetics. Adenocarcinoma, Mucinous / pathology. Adult. Aged. Aged, 80 and over. Carcinoma, Papillary / genetics. Carcinoma, Papillary / pathology. Cell Differentiation. DNA Methylation. DNA-Binding Proteins / genetics. Europe. Female. Gene Deletion. Genotype. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. MutS Homolog 2 Protein / genetics. Neoplasm Invasiveness. Neoplasm Staging. Nuclear Proteins / genetics. Phenotype. Polymerase Chain Reaction. Promoter Regions, Genetic. Proportional Hazards Models. Risk Assessment. Treatment Outcome

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  • (PMID = 19252434.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / DNA-Binding Proteins; 0 / G-T mismatch-binding protein; 0 / MLH1 protein, human; 0 / Nuclear Proteins; EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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60. Sugimoto M, Takada T, Yasuda H, Nagashima I, Amano H, Yoshida M, Miura F, Uchida T, Isaka T, Toyota N, Wada K, Takagi K, Kato K: Exceptional ultra-late recurrence of papilla Vater carcinoma after pancreaticoduodenectomy: two cases at 17 and 25 years. Hepatogastroenterology; 2005 May-Jun;52(63):940-3
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  • [Title] Exceptional ultra-late recurrence of papilla Vater carcinoma after pancreaticoduodenectomy: two cases at 17 and 25 years.
  • Cancer of the papilla Vater can remain clinically quiescent for decades prior to regional or distant recurrence.
  • This protracted disease-free interval challenges the concept of a "cure" for cancer of the papilla Vater.
  • In the first case reported here, a 74-year-old female underwent pancreaticoduodenectomy in 1985 for cancer of the papilla Vater revealed histologically as a well-differentiated papillotubular adenocarcinoma, stage IA (UICC classification).
  • The second case is that of an 82-year-old female who underwent pancreaticoduodenectomy in 1974 for cancer of the papilla Vater, histologically a well-differentiated adenocarcinoma, stage IA.
  • The ultra-late recurrences (>15 years) in these cases are highly exceptional and, to our knowledge, this is the first report of such recurrences in cancer of the papilla Vater.
  • Because cancer of the papilla Vater can recur in many prognostically favorable cases after prolonged disease-free intervals, the possibility of delayed recurrence should not be ignored.
  • [MeSH-major] Adenocarcinoma / diagnosis. Ampulla of Vater / surgery. Neoplasm Recurrence, Local / diagnosis. Pancreaticoduodenectomy. Postoperative Complications / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / blood. Biopsy. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Female. Follow-Up Studies. Humans. Liver / pathology. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lymphatic Metastasis. Tomography, X-Ray Computed

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  • (PMID = 15966237.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen
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61. Antinori A, Ciccoritti L, Coco C, Giuliante F, Magistrelli P, Nuzzo G, Picciocchi A: [Duodenocephalopancreatectomy for periampullary neoplasm in elderly patients]. Suppl Tumori; 2005 May-Jun;4(3):S58

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Duodenocephalopancreatectomy for periampullary neoplasm in elderly patients].
  • [Transliterated title] La duodenocefalopancreasectomia per neoplasia periampollare nel paziente anziano.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods

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  • (PMID = 16437903.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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62. Alibegov RA, Prokhorenko TI, Sergeev OA, Khlusov AN: [The long term results and survival prognostic factors of surgical treatment ampulla Vateri cancer]. Khirurgiia (Mosk); 2008;(4):27-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The long term results and survival prognostic factors of surgical treatment ampulla Vateri cancer].
  • Results of radical operative treatment of 21 patients with ampulla Vateri cancer are presented.
  • Factors having prognostic value for survival rate are the stage of disease, metastatic regional spread, tumor invasion in a head of a pancreas, microscopic picture of a pancreatitis in a phase of acute condition.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Risk Factors. Russia / epidemiology. Survival Rate / trends. Time Factors

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  • (PMID = 18454104.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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63. Grobmyer SR, Stasik CN, Draganov P, Hemming AW, Dixon LR, Vogel SB, Hochwald SN: Contemporary results with ampullectomy for 29 "benign" neoplasms of the ampulla. J Am Coll Surg; 2008 Mar;206(3):466-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Contemporary results with ampullectomy for 29 "benign" neoplasms of the ampulla.
  • STUDY DESIGN: We retrospectively reviewed our experience with ampullectomy in 29 patients with a preoperative benign histologic diagnosis over 15 years (1991 to 2006).
  • Ampullary adenomatous neoplasms were present in 89% of patients.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Humans. Middle Aged. Neoplasm Invasiveness. Predictive Value of Tests. Retrospective Studies. Treatment Outcome

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  • (PMID = 18308217.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Harewood GC, Pochron NL, Gostout CJ: Prospective, randomized, controlled trial of prophylactic pancreatic stent placement for endoscopic snare excision of the duodenal ampulla. Gastrointest Endosc; 2005 Sep;62(3):367-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prospective, randomized, controlled trial of prophylactic pancreatic stent placement for endoscopic snare excision of the duodenal ampulla.
  • [MeSH-major] Ampulla of Vater / surgery. Pancreatic Ducts / surgery. Pancreatic Neoplasms / surgery. Pancreatitis / prevention & control. Sphincterotomy, Endoscopic / methods. Stents
  • [MeSH-minor] Adult. Aged. Cholangiopancreatography, Endoscopic Retrograde / methods. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Postoperative Complications / prevention & control. Probability. Prognosis. Prospective Studies. Risk Assessment. Survival Rate. Treatment Outcome

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  • [CommentIn] Gastrointest Endosc. 2005 Sep;62(3):371-3 [16111954.001]
  • (PMID = 16111953.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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65. Yano F, Hama Y, Abe K, Iwasaki Y, Hatsuse K, Kusano S: Carcinoid tumor of the ampulla of Vater. Magnetic resonance imaging findings. Clin Imaging; 2005 May-Jun;29(3):207-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carcinoid tumor of the ampulla of Vater. Magnetic resonance imaging findings.
  • Carcinoid tumors arising from the ampulla of Vater are rare, and their magnetic resonance (MR) imaging findings have not been reported in the literature to date.
  • We report a case of carcinoid tumor of the ampulla of Vater and discuss the characteristic MR imaging findings.
  • The tumor was isointense relative to the muscle on both the T1- and T2-weighted images with heterogeneous enhancement after gadolinium administration.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoid Tumor / diagnosis. Contrast Media. Magnetic Resonance Imaging

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  • (PMID = 15855067.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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66. Ogawa H, Itoh S, Ikeda M, Suzuki K, Naganawa S: Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT. Radiology; 2008 Sep;248(3):876-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT.
  • PURPOSE: To evaluate the capabilities of multisection computed tomography (CT) in determining the likelihood of invasiveness of intraductal papillary mucinous neoplasm (IPMN).
  • RESULTS: The following findings showed significant differences among the three groups: maximum diameter of the main pancreatic duct (MPD), size (length of major axis) of the largest mural nodule in the MPD or in any associated cystic lesion, abnormal attenuating area in the surrounding parenchyma, calcification in the lesion, protrusion of the MPD into the ampulla of Vater, and bile duct dilatation.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Reproducibility of Results. Sensitivity and Specificity. Single-Blind Method

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  • [Copyright] RSNA, 2008
  • (PMID = 18632526.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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67. Clemente G, Sarno G, Giordano M, De Rose AM, Nuzzo G: Intramural duodenal diverticulum mimicking a periampullary neoplasm. Am J Surg; 2008 Oct;196(4):e31-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intramural duodenal diverticulum mimicking a periampullary neoplasm.
  • Contrast-enhanced computerized tomography revealed a small mass in the duodenal wall mimicking a periampullary neoplasm and, at endoscopic examination, a periampullary submucosal tumor was suspected.
  • The diagnosis of intramural duodenal diverticulum (IDD) was made by an x-ray barium meal that showed a finger-like sac filled with barium, the so-called "windsock sign."
  • [MeSH-minor] Adult. Ampulla of Vater / radiography. Barium Sulfate. Contrast Media. Diagnosis, Differential. Duodenal Neoplasms / radiography. Endoscopy, Gastrointestinal. Female. Humans. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 18614138.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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68. Casaretto E, Andrada DG, Granero LE: [Results of cephalic pancreaticoduodenectomy for ampullary carcinoma. Analysis of 18 consecutive cases]. Acta Gastroenterol Latinoam; 2010 Mar;40(1):22-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Results of cephalic pancreaticoduodenectomy for ampullary carcinoma. Analysis of 18 consecutive cases].
  • [Transliterated title] Resultados de la duodenopancreatectomía cefálica en el tratamiento del carcinoma de la ampolla de vater. Análisis de 18 casos consecutivos.
  • BACKGROUND: Complete resection offers the only potential cure for ampullary carcinoma.
  • AIM: The aim of this study was to assess the results of cephalic pancreaticoduodenectomy for patients with ampullary carcinoma based on mortality, hospital morbidity, late morbidity, and survival.
  • PATIENTS AND METHODS: We retrospectively and prospectively reviewed all patients who underwent cephalic pancreaticoduodenectomy, between October 1994 and October 2006 for ampullary carcinoma.
  • The tumor was unresectable in the remaining 2 patients.
  • Resection margins were tumor free (RO) in all patients.
  • CONCLUSIONS: Cephalic pancreaticoduodenectomy is the surgical procedure of choice for ampullary carcinoma, with low hospital mortality, and the best chance for cure in patients with node-negative disease.
  • [MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prospective Studies. Retrospective Studies. Treatment Failure

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  • (PMID = 20446393.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Argentina
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69. Matsuzawa G, Shirabe K, Gion T, Tsujita E, Ooya M, Kajiyama K, Nagaie T: Surgically resected undifferentiated carcinoma with osteoclast-like giant cells of the periampullary region involving the orifice of the papilla of Vater: Report of a case. Surg Today; 2010 Apr;40(4):376-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgically resected undifferentiated carcinoma with osteoclast-like giant cells of the periampullary region involving the orifice of the papilla of Vater: Report of a case.
  • We report the case of a 71-year-old man with periampullary carcinoma who underwent pancreaticoduodenectomy under the diagnosis of periampullary carcinoma.
  • Histologically, the neoplasm was composed of undifferentiated cells and evenly spaced osteoclast-like giant cells.
  • [MeSH-major] Ampulla of Vater. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 20339995.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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70. Kayahara M, Ohta T: Gross appearance of the ampullary tumor predicts lymph node metastasis and outcome. Dig Surg; 2010;27(2):127-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gross appearance of the ampullary tumor predicts lymph node metastasis and outcome.
  • BACKGROUND/AIMS: Patterns of lymph node involvement in carcinoma of the papilla of Vater (CPV) have not been studied in detail to date, and factors associated with lymphatic metastases and surgical outcome of this disease remain to be determined.
  • Gross appearance of the primary tumor and depth of tumor invasion correlated with lymph node involvement (p < 0.05, respectively).
  • Disease-specific survival correlated with the gross appearance of the primary tumor and nodal involvement.
  • Multivariate analysis indicated that the gross appearance of the tumor was the only significant independent predictor of a poor outcome.
  • CONCLUSIONS: Gross appearance of the tumor is the most important prognosticator of lymph node metastases in CPV.
  • [MeSH-major] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Lymph Node Excision. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Proportional Hazards Models. Statistics, Nonparametric. Survival Rate. Treatment Outcome

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  • [Copyright] (c) 2010 S. Karger AG, Basel.
  • (PMID = 20551657.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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71. Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J, Takasawa O, Obana T: Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study. Gastrointest Endosc; 2007 Oct;66(4):740-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study.
  • BACKGROUND: Endoscopic papillectomy is performed in selected patients with ampullary neoplasm, and, thus, accurate preoperative tumor staging is indispensable for its application.
  • PATIENTS AND INTERVENTIONS: EUS and transpapillary intraductal US (IDUS) were performed in 40 patients with ampullary neoplasm before surgery (n = 30) or endoscopic papillectomy (n = 10).
  • Ductal infiltration by a tumor into the bile duct (BD) or the pancreatic duct (PD) was also evaluated.
  • Tumor depiction by EUS and IDUS was achieved in 95% and 100% of the patients, respectively.
  • CONCLUSION: Although IDUS had a tendency of overestimation in tumor staging for ampullary neoplasm, it can provide useful information for making therapeutic decisions, especially in cases appropriate for endoscopic papillectomy.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms. Duodenoscopy / methods. Endosonography / methods. Preoperative Care / methods. Sphincterotomy, Endoscopic / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Adenoma / pathology. Adenoma / surgery. Adenoma / ultrasonography. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Reproducibility of Results

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  • (PMID = 17905017.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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72. Wagle PK, Shetty GS, Sampat M, Patel K: Ectopic pancreatic tissue mimicking ampullary tumor. Indian J Gastroenterol; 2005 Nov-Dec;24(6):265-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ectopic pancreatic tissue mimicking ampullary tumor.
  • Ectopic pancreas is an anomaly in the fusion of the two pancreatic buds where an ectopic rest develops at a place away from the normal site.
  • We report a 70-year-old lady who presented with obstructive jaundice; she was found to have an ampullary tumor highly suggestive of malignancy, for which she underwent pancreatico-duodenectomy.
  • However, histology showed ectopic pancreatic tissue in the ampulla.
  • [MeSH-major] Ampulla of Vater. Choristoma / diagnosis. Common Bile Duct Diseases / diagnosis. Common Bile Duct Neoplasms / diagnosis. Pancreas
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 16424630.001).
  • [ISSN] 0254-8860
  • [Journal-full-title] Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
  • [ISO-abbreviation] Indian J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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73. Park JE, Dong SH, Cho KH, Jang JY, Kim HJ, Kim BH, Chang YW, Chang R: [Successful resection of locally advanced gastrointestinal stromal tumor of the ampulla of Vater after treatment with imatinib]. Korean J Gastroenterol; 2010 Jul;56(1):39-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Successful resection of locally advanced gastrointestinal stromal tumor of the ampulla of Vater after treatment with imatinib].
  • Gastrointestinal stromal tumor (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract arising from Cajal's cells, expressing CD 117.
  • We report a case of unresectable primary GIST of the ampulla of Vater, which we were able to completely resect after treatment with a dosage of imatinib 400 mg daily for 5 months.
  • [MeSH-major] Ampulla of Vater / pathology. Antineoplastic Agents / therapeutic use. Gastrointestinal Stromal Tumors / surgery. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 20695129.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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74. Georgescu SO, Neacşu CN, Vintilă D, Popa P, Florea N, Mihailovici MS: The histopathologic type of the periampullary tumors. Is it important for survival? Chirurgia (Bucur); 2009 Nov-Dec;104(6):697-700
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The ampulla of Vater is a junction with four histologic epithelial types: ampullary, duodenal, pancreatic and biliary.
  • Using our database we assessed the overall survival based on histologic type, tumor stage, lymph nodes involvement, tumor size and the level of differentiation.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Ampulla of Vater. Duodenal Neoplasms / mortality. Duodenal Neoplasms / pathology. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis. Male. Medical Records. Middle Aged. Multivariate Analysis. Neoplasm Staging. Pancreaticoduodenectomy / mortality. Prognosis. Proportional Hazards Models. Retrospective Studies. Romania / epidemiology. Survival Analysis. Treatment Outcome

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  • (PMID = 20187467.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
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75. Katsinelos P, Kountouras J, Chatzimavroudis G, Zavos C, Paroutoglou G, Kotakidou R, Panagiotopoulou K, Papaziogas B: A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection. Surg Laparosc Endosc Percutan Tech; 2007 Dec;17(6):533-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection.
  • Endoscopic cholangiopancreatography revealed a depressed-type carcinoma at the ampulla of Vater and dilation of both the common bile and pancreatic ducts without intraductal filling defects.
  • Intraductal ultrasonography showed a hypoechoic mass limited to the ampulla of Vater.
  • Histologic examination of the resected specimen showed a completely excised well-differentiated adenocarcinoma limited to the ampulla of Vater.
  • Both accurate preoperative staging and proper histologic evaluation of the resected specimen seem to justify endoscopic treatment of early ampullary cancer by an experienced endoscopist.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Endosonography. Humans. Male. Neoplasm Staging. Treatment Outcome

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  • (PMID = 18097317.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Kwak JW, Paik CN, Jung SH, Chang UI, Lee KM, Chung WC, Yoo JY, Yang JM: An inflammatory myofibroblastic tumor of the ampulla of vater successfully managed with endoscopic papillectomy: report of a case. Gut Liver; 2010 Sep;4(3):419-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An inflammatory myofibroblastic tumor of the ampulla of vater successfully managed with endoscopic papillectomy: report of a case.
  • The documented sites in the gastrointestinal tract include the esophagus, small intestine, colon, appendix, rectum, pancreas, spleen, liver, and Meckel's diverticulum.
  • Biliary IMTs are rare, and IMTs arising from the ampulla of Vater have not been reported previously.
  • Herein we report the case of a 65-year-old woman with an extrahepatic biliary obstruction due to IMT of the ampulla of Vater, and a successful therapeutic approach using endoscopic ultrasonography and endoscopic papillectomy.

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  • (PMID = 20981226.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2956361
  • [Keywords] NOTNLM ; Ampulla of Vater / Endoscopic papillectomy / Inflammatory myofibroblastic tumor
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77. Lagoudianakis EE, Tsekouras D, Koronakis N, Chrysicos J, Archontovasilis F, Filis K, Katergiannakis V, Manouras A: A prospective comparison of ampullectomy with pancreaticoduodenectomy for the treatment of periampullary cancer. J BUON; 2008 Oct-Dec;13(4):569-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of our study was to compare local excision (LE) of the ampulla with standard pancreaticoduodenectomy (PD) for the treatment of periampullary cancer in terms of overall survival.
  • Inclusion criteria were primary tumor < or = 2 cm with no evidence of lymph node involvement or distant metastasis on abdominal computed tomography (CT).
  • The two groups were homogeneous with respect to age and gender as well as the size and origin of the primary neoplasm.
  • There was no correlation of the survival with age, gender, presence of lymph node metastasis, size of the primary tumor, type of surgery or histologic grade (x(2), p >0.05).
  • However, the origin of the tumor had major impact on survival, with pancreatic tumors having the worst prognosis.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery

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  • [ErratumIn] J BUON. 2009 Oct-Dec;14(4):737
  • (PMID = 19145682.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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78. Kim SC, Kim SH, Myung SJ, Choi JW, Song MH, Jo YJ, Park YS, Joo JE, Park SW: [A case of intraductal papillary mucinous neoplasm of the pancreas arising from pancreas divisum without ventral pancreatic duct of Wirsung]. Korean J Gastroenterol; 2006 Mar;47(3):218-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of intraductal papillary mucinous neoplasm of the pancreas arising from pancreas divisum without ventral pancreatic duct of Wirsung].
  • However, these cases are associated with incomplete type of pancreas divisum.
  • On endoscopic retrograde cholangiopancreatography, there was a severely bulging ampulla of Vater and patulous minor papilla draining mucinous material and a cystic lesion communicating with the dilated Santorini's duct without any communication with Wirsung's duct.
  • [MeSH-major] Carcinoma, Pancreatic Ductal. Pancreas / abnormalities. Pancreatic Ducts / abnormalities. Pancreatic Neoplasms

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  • (PMID = 16554676.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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79. Bahra M, Langrehr JM, Neuhaus P: [Carcinomas of the distal bile duct]. Chirurg; 2006 Apr;77(4):335-40
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  • Surgical approaches for achieving tumor-free resection margins (R0) are directly associated with the origin of the tumor.
  • Cancer of the distal bile duct has to be distinguished from ductal adenocarcinoma of the pancreas and carcinoma of the ampulla of Vater.
  • Curative surgery is possible if the tumor is diagnosed early and radical resection is feasible.
  • [MeSH-minor] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Humans. Lymph Node Excision / methods. Neoplasm Invasiveness. Neoplasm Staging. Pancreaticoduodenectomy / methods. Prognosis. Survival Rate

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  • (PMID = 16523255.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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80. Ridwelski K, Meyer F, Schmidt U, Lippert H: [Results of surgical treatment in ampullary and pancreatic carcinoma and its prognostic parameters after R0-resection]. Zentralbl Chir; 2005 Aug;130(4):353-61
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  • [Title] [Results of surgical treatment in ampullary and pancreatic carcinoma and its prognostic parameters after R0-resection].
  • [Transliterated title] Ergebnisse der chirurgischen Therapie beim Papillen- und Pankreaskarzinom sowie Prognoseparameter nach R0-Resektion. Chirurgie und Prognose des Pankreaskarzinoms.
  • INTRODUCTION: Resection is currently the only established reasonable therapeutic option with curative potential in pancreatic and ampullary carcinoma.
  • METHODS: Two-hundred-twenty patients with pancreatic and ampullary carcinoma (mean age, 61.4 years; 104 females/116 males) underwent surgery.
  • Histologic investigation revealed 19 carcinomas of the papilla of Vater and 201 ductal pancreatic carcinomas.
  • RESULTS: Hundred-ten patients underwent tumor resection with primary curative intention (50 %): 96 resections of the pancreatic head, 2 total pancreatectomies and 12 left resections of the pancreas.
  • Five-year survival-rate of carcinoma of the papilla of Vater and pancreatic carcinoma was 73.3 % and 16.2 %, respectively (median survival time was 66.0 and 14.0 months, respectively).
  • In addition, prognosis after successful R0-resection is determined significantly by tumor site, stage of the tumor (according to UICC), T- and N-category.
  • CONCLUSION: Resection of pancreatic and ampullary carcinoma according to oncological criteria with tumor-free margins can be considered a treatment option with curative intention and potential.
  • Interventions with primary palliative intention or resections with microscopically or macroscopically detectable tumor residual in situ lead to no significant or only marginal prolongation of survival time.
  • They are of value only for treatment of tumor-associated complications and problems.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Pancreatic Ductal / surgery. Common Bile Duct Neoplasms / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Female. Gastroenterostomy. Humans. Male. Middle Aged. Neoplasm Staging. Pancreas / pathology. Postoperative Complications. Prognosis. Survival Analysis. Time Factors

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  • (PMID = 16103961.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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81. Tannapfel A, Wittekind C: [The current TNM system for gastrointestinal tumors part II]. Pathologe; 2010 Sep;31(5):348-52
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  • [Transliterated title] Aktuelles TNM-System der gastrointestinalen Tumoren Teil II.
  • No changes were made for tumours of the anal canal, the gallbladder (excluding the inclusion of tumours of the cystic duct) and tumours of the pancreas and the ampulla of Vater.
  • [MeSH-major] Digestive System Neoplasms / pathology. Neoplasm Staging / methods
  • [MeSH-minor] Ampulla of Vater / pathology. Appendiceal Neoplasms / classification. Appendiceal Neoplasms / pathology. Carcinoid Tumor / classification. Carcinoid Tumor / pathology. Carcinoma, Hepatocellular / classification. Carcinoma, Hepatocellular / pathology. Cholangiocarcinoma / classification. Cholangiocarcinoma / pathology. Colorectal Neoplasms / classification. Colorectal Neoplasms / pathology. Common Bile Duct Neoplasms / pathology. Disease Progression. Gallbladder Neoplasms / classification. Gallbladder Neoplasms / pathology. Gastrointestinal Stromal Tumors / classification. Gastrointestinal Stromal Tumors / pathology. Humans. Lymphatic Metastasis / pathology. Mitotic Index. Neoplasm Invasiveness / pathology. Neuroendocrine Tumors / classification. Neuroendocrine Tumors / pathology. Pancreatic Neoplasms / classification. Pancreatic Neoplasms / pathology. Prognosis. Rectal Neoplasms / classification. Rectal Neoplasms / pathology

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  • [CommentIn] Pathologe. 2010 Sep;31(5):353-4 [20809402.001]
  • (PMID = 20798945.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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82. Nakazawa K, Dobashi Y, Suzuki S, Fujii H, Takeda Y, Ooi A: Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol; 2005 Jul;206(3):356-65
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  • Overexpression of the tyrosine kinase receptor proteins was examined by immunohistochemistry in 221 biliary tract carcinomas, of which 28 were from the intrahepatic bile duct, 78 from the extrahepatic bile duct, 89 from the gall bladder, and 26 from the ampulla of Vater.
  • Overexpression of ErbB-2 was found in 15.7%, 11.5%, and 5.1% of carcinomas of the gall bladder, ampulla of Vater, and extrahepatic bile duct, respectively, and gene amplification was present in 79% of these.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Ampulla of Vater / pathology. Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / pathology. Common Bile Duct Neoplasms / genetics. Common Bile Duct Neoplasms / pathology. Female. Gallbladder Neoplasms / genetics. Gallbladder Neoplasms / pathology. Gene Amplification / genetics. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence / methods. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Proteins / genetics

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 15892172.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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83. Alibegov RA, Prokhorenko TI, Sergeev OA, Khlusov AN: [Clinico-morphological factors of prognosis in cancer of the major duodenum papilla]. Vestn Khir Im I I Grek; 2008;167(2):26-8

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  • The data of a univariant analysis show that favorable factors of survival are the early stage of the tumor disease, the absence of metastatic lesion of the regional lymph nodes, tumor invasion into the pancreas and a microscopic picture of pancreatitis in the stage of exacerbation.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Disease Progression. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging / methods. Pancreatic Neoplasms / pathology. Prognosis. Retrospective Studies. Russia / epidemiology. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 18522181.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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84. Kolb A, Kleeff J, Friess H, Büchler MW: [The effect of R1 resection in the hepatobiliary pancreatic system]. Chirurg; 2007 Sep;78(9):802-9
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  • [Transliterated title] Bedeutung der R1-Resektion im hepatobiliär-pankreatischen System.
  • The reported R1 rates for different HPB tumor entities vary considerably, most likely because of ambiguities in the exact definition of R1 resection and the lack of standardized histopathologic examination and reporting.
  • In most cases, however, R1 resections are determined by the anatomic location of the tumor and the growth pattern (e.g. pancreatic cancer with perineural invasion).
  • [MeSH-major] Ampulla of Vater. Bile Duct Neoplasms / surgery. Bile Ducts, Intrahepatic. Carcinoma, Hepatocellular / surgery. Cholangiocarcinoma / surgery. Common Bile Duct Neoplasms / surgery. Gallbladder Neoplasms / surgery. Hepatic Duct, Common. Liver Neoplasms / surgery. Neoplasm, Residual / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Gallbladder / pathology. Humans. Klatskin Tumor / mortality. Klatskin Tumor / pathology. Klatskin Tumor / surgery. Liver / pathology. Pancreas / pathology. Quality of Life

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  • (PMID = 17680231.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 61
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85. Zacharias T, Oussoultzoglou E, Jaeck D, Pessaux P, Bachellier P: Surgery for recurrence of periampullary malignancies. J Gastrointest Surg; 2009 Apr;13(4):760-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 19050979.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Aloysius MM, Zaitoun AM, Awad S, Ilyas M, Rowlands BJ, Lobo DN: Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer. Br J Surg; 2010 Aug;97(8):1269-78
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  • [Title] Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer.
  • Overexpression of MUC4 and MUC5AC correlated with tumour recurrence (P = 0.001 and P = 0.034 respectively).
  • [MeSH-major] Ampulla of Vater. Antigens, CD56 / metabolism. Biomarkers, Tumor / metabolism. Common Bile Duct Neoplasms / diagnosis. Mucins / metabolism
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness. Pancreatitis, Chronic / diagnosis. Prognosis

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  • [Copyright] Copyright (c) 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • (PMID = 20602499.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / Mucins
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87. Kelemen D, Papp R, Baracs J, Káposztás Z, Al-Farhat Y, Horváth OP: [Treatment of pancreatic and periampullary tumours in our department in the last 10 years]. Magy Seb; 2009 Oct;62(5):287-92
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  • [Transliterated title] Pancreas- és periampullaris tumorok kezelése az elmúlt 10 évben klinikánkon.
  • The preoperative data (age, gender, site of the tumour, characteristic clinical signs), as well as surgical methods are overviewed.
  • [MeSH-major] Ampulla of Vater. Digestive System Surgical Procedures / adverse effects. Digestive System Surgical Procedures / methods. Palliative Care. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Pancreatectomy / adverse effects. Pancreatectomy / methods. Pancreatic Fistula / etiology. Pancreaticoduodenectomy / adverse effects. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19828417.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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88. Lu ZC, Guo JM, Zhang YL, Tian PL, Zhang L, Yu JP, Bao XY: [Comparison of endoscopic ultrasonography with computer-assisted tomography in the determination of preoperative stage and resectability of pancreatic and ampullary cancers]. Zhonghua Zhong Liu Za Zhi; 2006 Jun;28(6):441-4
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  • [Title] [Comparison of endoscopic ultrasonography with computer-assisted tomography in the determination of preoperative stage and resectability of pancreatic and ampullary cancers].
  • OBJECTIVE: To study and compare the accuracy and sensitivity of endoscopic ultrasonography (EUS) and CT scaning in determination of preoperative stage and vascular invasion by pancreatic and ampullary cancers.
  • METHODS: Fourty-two pancreatic cancer patients and 18 ampullary cancer patients were studied.
  • The structures of each part of pancreatic head and ampullary together with surrounding vessels were scanned.
  • 1996 to May 2004, a total of 42 pancreatic cancer patients and 18 ampullary cancer patients were examined by EUS.
  • The results of stage and vascular invasion determined by EUS in this series were as following; pancreatic cancer group (n = 42): accuracy in T2-4 stage was 100.0% (5/5), 75.0% (9/12) and 48.0% (12/25), respectively; ampullary cancer group (n = 18): T1-4 stage was 75.0% (3/4), 66.7% (2/3), 75.0% (6/8) and 33.3% (1/3), respectively; the accuracy in N stage: P-group: 80.0% in N1 (4/5), 90.0% in N0 (9/10); A-group: 50.0% in N1 (3/6), 91.0% in N0 (10/11).
  • CONCLUSION: Endoscopic ultrosonography being one of the best image examinations to determine the stage and vascular invasion for pancreatic and ampullary cancer paitients is able to detect small pancreatic or ampullary cancer less than 2.0 cm in diameter due to its high resolution; but can not detect the secondary multiple distal metastases such as spread into the liver, peritonium or hepatoduodenal ligament, etc. due to its ultrasound depth limitation.
  • [MeSH-major] Ampulla of Vater / ultrasonography. Common Bile Duct Neoplasms / ultrasonography. Endosonography. Pancreas / ultrasonography. Pancreatic Neoplasms / ultrasonography
  • [MeSH-minor] Female. Humans. Lymphatic Metastasis. Male. Mesenteric Veins / pathology. Mesenteric Veins / radiography. Mesenteric Veins / ultrasonography. Neoplasm Invasiveness. Neoplasm Staging. Pancreatectomy. Portal Vein / pathology. Portal Vein / radiography. Portal Vein / ultrasonography. Preoperative Care. Tomography, X-Ray Computed. Vascular Neoplasms / pathology. Vascular Neoplasms / radiography. Vascular Neoplasms / ultrasonography

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  • (PMID = 17152491.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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89. Santini D, Vincenzi B, Tonini G, Scarpa S, Vasaturo F, Malacrino C, Vecchio F, Borzomati D, Valeri S, Coppola R, Magistrelli P, Nuzzo G, Picciocchi A: Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. Clin Cancer Res; 2005 May 15;11(10):3784-9

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  • [Title] Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients.
  • PURPOSE: To identify potential prognostic molecular factors in ampullary adenocarcinoma that could be of significant importance.
  • To this end, we examined the possible prognostic significance of cyclooxygenase-2 (Cox-2) and Survivin expression and the apoptotic index in a cohort of uniformly treated patients with ampullary cancer treated with radical surgical excision.
  • EXPERIMENTAL DESIGN: The entry criteria were that the patients have a pathologic diagnosis of ampullary cancer which had been resected.
  • RESULTS: Thirty-nine tumor specimens from resected ampullary adenocarcinoma patients were included.
  • CONCLUSIONS: The results of the present article provide, for the first time, evidence that Cox-2 expression, but not Survivin expression, may represent a significant prognostic factor after surgical resection in patients affected by cancer of the ampulla of Vater.
  • Further studies are required to determine whether Cox-2 inhibitors may be useful for the therapy or prevention of ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / genetics. Common Bile Duct Neoplasms / pathology. Gene Expression Profiling. Prostaglandin-Endoperoxide Synthases / biosynthesis. Prostaglandin-Endoperoxide Synthases / genetics
  • [MeSH-minor] Adult. Aged. Apoptosis. Cyclooxygenase 2. Female. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Male. Membrane Proteins. Microtubule-Associated Proteins / biosynthesis. Microtubule-Associated Proteins / genetics. Middle Aged. Neoplasm Proteins. Predictive Value of Tests. Prognosis

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  • (PMID = 15897577.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Membrane Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human; EC 1.14.99.1 / Prostaglandin-Endoperoxide Synthases
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90. Aloysius MM, Hewavisenthi SJ, Bates TE, Rowlands BJ, Lobo DN, Zaitoun AM: Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays. World J Surg; 2010 Sep;34(9):2115-21
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  • [Title] Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays.
  • Expression of Ki-67 was assessed as the percentage of cancer cell nuclei expressing MIB1, MI as the mean percentage of Ki-67 from 10 random high-power fields, and M/V was calculated after standardizing MI for connective tissue volume and microscope parameters in the tumor using established protocols.
  • There was no statistically significant difference in survival, based on M/V score, for tumors of the intestinal subtype (ampullary and duodenal adenocarcinoma).
  • CONCLUSIONS: In periampullary cancers, Ki-67 and MI are proliferative indices predictive of tumor behavior.
  • [MeSH-major] Ampulla of Vater. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic. Carcinoma, Pancreatic Ductal / metabolism. Cholangiocarcinoma / metabolism. Common Bile Duct Neoplasms / metabolism. Duodenal Neoplasms / metabolism. Ki-67 Antigen / analysis. Mitotic Index. Pancreatic Neoplasms / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Lymphatic Metastasis. Microarray Analysis. Neoplasm Invasiveness

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  • (PMID = 20556608.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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91. Ishida M, Egawa S, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Furukawa T, Unno M: Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma. J Hepatobiliary Pancreat Surg; 2007;14(5):522-5
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  • [Title] Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma.
  • A 72-year-old woman, who had undergone pylorus-preserving pancreatoduodenectomy 3 years before for cancer of Vater's papilla associated with a branch-type intraductal papillary-mucinous adenoma (IPMA), developed dilatation of the main duct and a nodular lesion in the remnant pancreas.
  • Total pancreatectomy was performed, which revealed that the lesion was intraductal papillary-mucinous adenocarcinoma (IPMC) with minimal invasion, suggesting the metachronous multicentric occurrence of this intraductal papillary-mucinous neoplasm (IPMN).
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Ampulla of Vater. Carcinoma, Pancreatic Ductal / diagnosis. Common Bile Duct Neoplasms / surgery. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 17909725.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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92. Barinagarrementeria R: [Update on endoscopic management of malignant obstructive jaundice]. Rev Gastroenterol Mex; 2005 Jul;70 Suppl 1:95-106
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  • [Transliterated title] Actualidades en el manejo endoscópico de la ictericia obstructiva maligna.
  • The diagnosis of bilio-pancreatic diseases is carried out when patients present symptoms of biliary obstruction.
  • The majority of these patients cannot receive curative treatment at the time of the diagnosis.
  • Endoscopic cholangiography can confirm the tumor's etiology with a biopsy, cytology or aspiration at the level of the stenosis.
  • [MeSH-major] Adenocarcinoma / complications. Ampulla of Vater. Bile Duct Neoplasms / complications. Bile Ducts, Intrahepatic. Cholangiocarcinoma / complications. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / complications. Jaundice, Obstructive / etiology. Pancreatic Neoplasms / complications
  • [MeSH-minor] Cholangiography. Cholestasis, Extrahepatic / diagnosis. Cholestasis, Intrahepatic / diagnosis. Common Bile Duct / pathology. Diagnosis, Differential. Endosonography. Humans. Neoplasm Staging. Palliative Care. Pancreas / pathology. Tomography, Spiral Computed

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  • (PMID = 17469413.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 101
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93. Warnick P, Bahra M, Andreou A, Neuhaus P, Glanemann M: [Second-look operation in pancreatic carcinoma previously assessed as unresectable]. Zentralbl Chir; 2010 Feb;135(1):70-4
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  • BACKGROUND: The only curative therapy for patients with pancreatic carcinoma consists of -complete surgical tumour removal.
  • Preoperative diagnostic investigations may help, however, the definite decision on tumour resectability can only be made intraoperatively during explorative laparotomy.
  • RESULTS: During the second-look operation 13 patients (76.5 %) underwent tumour resection, where-as in 4 patients (23.5 %) the tumour remained non-resectable.
  • Mean survival in patients after tumour resection was increased, reach-ing 17.6 months compared to 6.5 months in patients with non-resectable pancreatic cancer.
  • Although considered as non-resectable during prior laparotomy else-where, the majority of patients (76.5 %) suffered from a resectable tumour disease.
  • Moreover, most of them (69 %) underwent complete (R0) -tumour removal.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma, Pancreatic Ductal / surgery. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Academic Medical Centers. Adult. Aged. Disease Progression. Female. Follow-Up Studies. Germany. Hospitals, General / statistics & numerical data. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Palliative Care. Pancreas / pathology. Pancreas / surgery. Prognosis. Referral and Consultation / statistics & numerical data. Reoperation / statistics & numerical data. Survival Rate. Tomography, X-Ray Computed

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  • [Copyright] Georg Thieme Verlag Stuttgart, New York.
  • (PMID = 20162503.001).
  • [ISSN] 1438-9592
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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94. Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OP, Gladhaug IP: Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. BMC Cancer; 2008;8:170
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Resectable adenocarcinomas in the pancreatic head, by definition "periampullary", originate from ampullary, duodenal, biliary, or ductal pancreatic epithelium.
  • The aim of the study was to determine whether the histologic type of differentiation is an independent prognostic factor in periampullary adenocarcinoma, and whether tumour origin predicts the prognosis in pancreatobiliary type carcinomas independently of resection margin involvement, tumour size, nodal involvement, perineural and vascular infiltration, and degree of differentiation.
  • Histologic type of differentiation and tumour origin were compared as predictors of survival, and the results were validated by comparison with a historical control group consisting of 99 consecutive pancreaticoduodenectomies performed before standardization of histopathologic evaluation.
  • RESULTS: Both in the study group (n = 114) and in the historical control group (n = 99), the histologic type of differentiation independently predicted survival, while tumour origin predicted survival only in univariate analysis.
  • Independent adverse predictors of survival in the study group were pancreatobiliary type differentiation (p < 0.001; HR 3.1; CI 1.8-5.1), regional lymph node involvement (p < 0.001; HR 2.5; CI 1.5-4.4), vessel involvement (p = 0.012; HR 1.9; CI 1.2-3.1), and increasing tumour diameter (measured in cm, p = 0.011; HR 1.3; CI 1.1-1.5).
  • For pancreatobiliary differentiated adenocarcinomas (n = 67), lymph node status, vessel involvement, and tumour diameter remained independent prognostic factors, while tumour origin did not independently predict the prognosis due to significant association with tumour size (p < 0.001) and lymph node involvement (p = 0.004).
  • Lymph node involvement, vessel infiltration, and increasing tumour diameter are adverse predictors of survival in tumours with pancreatobiliary differentiation.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Ampulla of Vater / pathology. Pancreatic Ducts / pathology. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Needle. Case-Control Studies. Cell Differentiation. Common Bile Duct Neoplasms / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness / pathology. Pancreatectomy / methods. Pancreaticoduodenectomy / methods. Probability. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Survival Analysis. Treatment Outcome

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  • [Cites] Int J Oncol. 2000 Nov;17(5):921-6 [11029493.001]
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  • (PMID = 18547417.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2430209
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95. Byun JR, Jahng JH, Song JC, Yu JS, Lee DK: Supine position endoscopic retrograde cholangiopancreatography in a patient with situs ambiguous with polysplenia. Dig Endosc; 2010 Oct;22(4):322-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These findings are compatible with situs ambiguous with polysplenia and were suggestive of a periampullary tumor.
  • Microscopic findings of the biopsy specimen of papillary mass were compatible with an adenocarcinoma of the ampulla of Vater.
  • [MeSH-major] Abnormalities, Multiple / pathology. Ampulla of Vater / pathology. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / radiography. Common Bile Duct Neoplasms / surgery. Spleen / abnormalities
  • [MeSH-minor] Biopsy. Female. Humans. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Supine Position. Tomography, X-Ray Computed

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  • [Copyright] © 2010 The Authors. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society.
  • (PMID = 21175488.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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96. Yuan LW, Tang W, Kokudo N, Seyama Y, Shi YZ, Karako H, Zhao B, Sugawara Y, Nagawa H, Makuuchi M: Disruption of pRb-p16INK4 pathway: a common event in ampullary carcinogenesis. Hepatogastroenterology; 2005 Jan-Feb;52(61):55-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disruption of pRb-p16INK4 pathway: a common event in ampullary carcinogenesis.
  • Our objective is to evaluate its role in tumorigenesis and the development of ampullary cancer.
  • METHODOLOGY: We examined expression status of p16INK4 protein and pRb immunohistochemically and assessed their possible prognostic relevance in 36 ampullary cancers.
  • RESULTS: Thirty-four specimens (94.4%) exhibited alteration of p16INK4 and/or pRb expression, with 63.9% (23/36) of cancers showing p16INK4 negative expression and 94.4% (34/36) pRb abnormal expression. p16INK4 protein negative expression correlated significantly with tumor progression features such as advanced tumor stages (p=0.0291), lymph node metastasis (p=0.005), pancreas invasion (p=0.0002) and duodenum invasion (p=0.0101).
  • Cases with both p16RNK4 protein negative expression and pRb overexpression showed poorer differentiation, more invasive growth (p=0.0425), higher level tumor stages (p=0.0079) and more frequent pancreas invasion (p=0.0024), compared with the others. p16INK4 protein expression showed no relationship with pRb expression (p=0.2199).
  • CONCLUSIONS: The disruption of the pRb-p16NK4 pathway plays an important role in ampullary carcinogenesis, the absence of p16INK4 protein expression might be involved in ampullary tumor progression.
  • [MeSH-major] Ampulla of Vater / metabolism. Common Bile Duct Neoplasms / etiology. Common Bile Duct Neoplasms / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Retinoblastoma Protein / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 15782994.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein
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97. Schönleben F, Qiu W, Allendorf JD, Chabot JA, Remotti HE, Su GH: Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. J Gastrointest Surg; 2009 Aug;13(8):1510-6
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  • [Title] Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.
  • BACKGROUND: Mutations of KRAS are known to occur in periampullary and ampullary adenomas and carcinomas.
  • This study aimed to elucidate possible roles of BRAF and PIK3CA in the development of ampullary and periampullary adenomas and carcinomas.
  • METHODS: Mutations of BRAF, NRAS, HRAS, KRAS, and PIK3CA were evaluated in seven adenomas, seven adenomas with carcinoma in situ, and 21 adenocarcinomas of the periampullary duodenal region and the ampulla of Vater.
  • CONCLUSION: Our data provide evidence that oncogenic properties of KRAS and BRAF but not NRAS, HRAS, and PIK3CA contribute to the tumorigenesis of periampullary and ampullary tumors; BRAF mutations occur more frequently in periampullary than ampullary neoplasms.

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  • (PMID = 19440799.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701; United States / NCI NIH HHS / CA / CA127701-01A2; United States / NCI NIH HHS / CA / R01CA109525; United States / NCI NIH HHS / CA / R01 CA109525; United States / NCI NIH HHS / CA / CA109525-05; United States / NCI NIH HHS / CA / R21 CA127701-01A2; United States / NCI NIH HHS / CA / R21CA127701
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.137 / PIK3CA protein, human; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
  • [Other-IDs] NLM/ NIHMS164917; NLM/ PMC3915027
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98. Jerraya H, Bel Haj Salah R, Ben Mena K, Haouet K, Zaouche A: Stromal tumor of the ampulla of vater: report of a case and systematic review of reported cases. Tunis Med; 2009 Sep;87(9):556-9

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  • [Title] Stromal tumor of the ampulla of vater: report of a case and systematic review of reported cases.
  • The localization of stromal tumours in the ampulla of Vater (STAV) is very rare.
  • Key words used were "ampulla of Vater" and "Gastrointestinal stromal tumor" and "CD 117".
  • STAV is a tumor of adult after the age of fifty.
  • Gastroduodenal endoscopy with biopsies and immunoassaying allows positive preoperative diagnosis in the 5 cases.
  • Treatment should be duodenopancreatectomy since the tumor is often malignant (5 cases).
  • [MeSH-major] Ampulla of Vater. Gastrointestinal Stromal Tumors

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  • (PMID = 20180372.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] Tunisia
  • [Number-of-references] 13
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99. Furuse J, Okusaka T, Ohkawa S, Nagase M, Funakoshi A, Boku N, Yamao K, Yamaguchi T, Sato T: A phase II study of uracil-tegafur plus doxorubicin and prognostic factors in patients with unresectable biliary tract cancer. Cancer Chemother Pharmacol; 2009 Dec;65(1):113-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Patients with histologically or cytologically confirmed, measurable biliary tract cancer, including intrahepatic or extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary cancer, who were not suitable candidates for surgery, were eligible for the study.
  • [MeSH-minor] Aged. Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / mortality. Disease-Free Survival. Doxorubicin / administration & dosage. Female. Humans. L-Lactate Dehydrogenase / blood. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Prognosis. Survival Rate. Tegafur / administration & dosage. Treatment Outcome. Uracil / administration & dosage

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  • (PMID = 19404641.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 80168379AG / Doxorubicin; EC 1.1.1.27 / L-Lactate Dehydrogenase
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100. Poultsides GA, Frederick WA: Carcinoid of the ampulla of Vater: morphologic features and clinical implications. World J Gastroenterol; 2006 Nov 21;12(43):7058-60
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  • [Title] Carcinoid of the ampulla of Vater: morphologic features and clinical implications.
  • Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice.
  • The published data indicate that these tumors, in contrast to their midgut counterparts, metastasize in approximately half of cases irrespective of primary tumor size.
  • Therefore, radical excision in the form of pancreaticoduodenectomy is recommended regardless of tumor size.
  • Tumor-targeted radioactive therapy is a newly emerging treatment option.
  • We here report case of a carcinoid tumor of the ampulla of Vater presenting as painless jaundice in a 65-year old man and review the relevant literature, giving special attention to the morphologic features, clinical characteristics, and treatment modalities associated with this disease process.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoid Tumor / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Jaundice / diagnosis. Jaundice / pathology. Male

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  • (PMID = 17109507.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 12
  • [Other-IDs] NLM/ PMC4087356
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