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1. Byun JR, Jahng JH, Song JC, Yu JS, Lee DK: Supine position endoscopic retrograde cholangiopancreatography in a patient with situs ambiguous with polysplenia. Dig Endosc; 2010 Oct;22(4):322-4
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  • These findings are compatible with situs ambiguous with polysplenia and were suggestive of a periampullary tumor.
  • Microscopic findings of the biopsy specimen of papillary mass were compatible with an adenocarcinoma of the ampulla of Vater.
  • [MeSH-major] Abnormalities, Multiple / pathology. Ampulla of Vater / pathology. Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / radiography. Common Bile Duct Neoplasms / surgery. Spleen / abnormalities
  • [MeSH-minor] Biopsy. Female. Humans. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Supine Position. Tomography, X-Ray Computed

  • Genetic Alliance. consumer health - Polysplenia.
  • Genetic Alliance. consumer health - Situs Ambiguous.
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  • [Copyright] © 2010 The Authors. Digestive Endoscopy © 2010 Japan Gastroenterological Endoscopy Society.
  • (PMID = 21175488.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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2. Alibegov RA, Prokhorenko TI, Sergeev OA, Khlusov AN: [Clinico-morphological factors of prognosis in cancer of the major duodenum papilla]. Vestn Khir Im I I Grek; 2008;167(2):26-8
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  • The data of a univariant analysis show that favorable factors of survival are the early stage of the tumor disease, the absence of metastatic lesion of the regional lymph nodes, tumor invasion into the pancreas and a microscopic picture of pancreatitis in the stage of exacerbation.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Disease Progression. Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging / methods. Pancreatic Neoplasms / pathology. Prognosis. Retrospective Studies. Russia / epidemiology. Survival Rate. Time Factors. Treatment Outcome

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  • (PMID = 18522181.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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3. Kondo S, Takada T, Miyazaki M, Miyakawa S, Tsukada K, Nagino M, Furuse J, Saito H, Tsuyuguchi T, Yamamoto M, Kayahara M, Kimura F, Yoshitomi H, Nozawa S, Yoshida M, Wada K, Hirano S, Amano H, Miura F, Japanese Association of Biliary Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japan Society of Clinical Oncology: Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment. J Hepatobiliary Pancreat Surg; 2008;15(1):41-54
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  • [Title] Guidelines for the management of biliary tract and ampullary carcinomas: surgical treatment.
  • Although hepatectomy and/or pancreaticoduodenectomy are preferable for the curative resection of bile duct cancer, extrahepatic bile duct resection alone is also considered in patients for whom it is judged that curative resection would be achieved after a strict diagnosis of its local extension.
  • Pancreaticoduodenectomy is indicated for ampullary carcinoma, and limited operation is also indicated for carcinoma in adenoma.
  • The prognostic factors after resection for ampullary carcinoma include lymph node metastasis, pancreatic invasion, and perineural invasion.
  • [MeSH-major] Ampulla of Vater / surgery. Biliary Tract Neoplasms / surgery. Carcinoma / surgery
  • [MeSH-minor] Biliary Tract / pathology. Biliary Tract Surgical Procedures / methods. Evidence-Based Medicine / methods. Humans. Neoplasm Staging. Preoperative Care / methods. Survival Rate

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  • (PMID = 18274843.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC2794356
  • [Investigator] Kai M; Kimura Y; Sawada S; Shimizu H; Nakagawara H; Nakachi K; Yoshitome H; Saisyo H; Ryu M; Shikata S; Nimura Y
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4. Fujita T, Konishi M, Gotohda N, Takahashi S, Nakagohri T, Kojima M, Kinoshita T: Invasive micropapillary carcinoma of the ampulla of Vater with extensive lymph node metastasis: Report of a case. Surg Today; 2010 Dec;40(12):1197-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Invasive micropapillary carcinoma of the ampulla of Vater with extensive lymph node metastasis: Report of a case.
  • We report a case of invasive micropapillary carcinoma of the papilla of Vater.
  • Detailed investigations revealed a tumor in the periampullary region, and pancreatoduodenectomy was performed for cancer of the ampulla of Vater.
  • Microscopic examination of the resected specimen revealed a tumor composed mainly of carcinoma cells arranged in micropapillary structures, with extensive regional lymph node metastasis.
  • Tumor recurrence with progressive ascites and hydronephrosis was found 8 months after surgery, and the patient died of the disease 20 months after surgery.
  • [MeSH-major] Ampulla of Vater / pathology. Ampulla of Vater / surgery. Carcinoma, Papillary / pathology. Carcinoma, Papillary / surgery. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Fatal Outcome. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 21110170.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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5. Seewald S, Omar S, Soehendra N: Endoscopic resection of tumors of the ampulla of Vater: how far up and how deep down can we go? Gastrointest Endosc; 2006 May;63(6):789-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic resection of tumors of the ampulla of Vater: how far up and how deep down can we go?
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic
  • [MeSH-minor] Algorithms. Humans. Lymphatic Metastasis. Neoplasm Invasiveness

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  • [CommentOn] Gastrointest Endosc. 2006 May;63(6):783-8 [16650538.001]
  • (PMID = 16650539.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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6. Yuan LW, Tang W, Kokudo N, Seyama Y, Shi YZ, Karako H, Zhao B, Sugawara Y, Nagawa H, Makuuchi M: Disruption of pRb-p16INK4 pathway: a common event in ampullary carcinogenesis. Hepatogastroenterology; 2005 Jan-Feb;52(61):55-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disruption of pRb-p16INK4 pathway: a common event in ampullary carcinogenesis.
  • Our objective is to evaluate its role in tumorigenesis and the development of ampullary cancer.
  • METHODOLOGY: We examined expression status of p16INK4 protein and pRb immunohistochemically and assessed their possible prognostic relevance in 36 ampullary cancers.
  • RESULTS: Thirty-four specimens (94.4%) exhibited alteration of p16INK4 and/or pRb expression, with 63.9% (23/36) of cancers showing p16INK4 negative expression and 94.4% (34/36) pRb abnormal expression. p16INK4 protein negative expression correlated significantly with tumor progression features such as advanced tumor stages (p=0.0291), lymph node metastasis (p=0.005), pancreas invasion (p=0.0002) and duodenum invasion (p=0.0101).
  • Cases with both p16RNK4 protein negative expression and pRb overexpression showed poorer differentiation, more invasive growth (p=0.0425), higher level tumor stages (p=0.0079) and more frequent pancreas invasion (p=0.0024), compared with the others. p16INK4 protein expression showed no relationship with pRb expression (p=0.2199).
  • CONCLUSIONS: The disruption of the pRb-p16NK4 pathway plays an important role in ampullary carcinogenesis, the absence of p16INK4 protein expression might be involved in ampullary tumor progression.
  • [MeSH-major] Ampulla of Vater / metabolism. Common Bile Duct Neoplasms / etiology. Common Bile Duct Neoplasms / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Retinoblastoma Protein / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 15782994.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein
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7. Sato Y, Ichimura K, Tanaka T, Takata K, Morito T, Sato H, Kondo E, Yanai H, Ohara N, Oka T, Yoshino T: Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas. J Clin Pathol; 2008 Mar;61(3):377-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They are often localised tumours with multiple polyps around the ampulla of Vater.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Blotting, Southern. Chromosomes, Human, Pair 14. Chromosomes, Human, Pair 18. Female. Gene Rearrangement. Genes, Immunoglobulin. Genes, bcl-2. Humans. Immunoglobulin Heavy Chains / genetics. Immunoglobulin Variable Region / genetics. Immunophenotyping. Male. Middle Aged. Neoplasm Staging. Sequence Analysis, DNA. Translocation, Genetic

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  • (PMID = 17601964.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulin Heavy Chains; 0 / Immunoglobulin Variable Region
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8. Bloomston M, Kneile J, Butterfield M, Dillhoff M, Muscarella P, Ellison EC, Melvin WS, Croce CM, Pichiorri F, Huebner K, Frankel WL: Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features. Ann Surg Oncol; 2009 Aug;16(8):2331-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Wwox has been understudied in pancreatobiliary cancers, especially in relation to other involved tumor suppressors.
  • We have assessed the status of the Fhit and Wwox proteins encoded by DNA damage susceptible chromosome fragile sites encompassed by FHIT and WWOX tumor suppressor genes.
  • METHODS: Pancreatic, gallbladder and ampullary cancers, normal pancreas, chronic pancreatitis, and benign gallbladder specimens were stained for expression of Fhit, Fhit effector protein Fdxr, Wwox, and other tumor suppressors by immunohistochemistry, and comparisons were made between benign and malignant tissue.
  • RESULTS: Fhit and Wwox were ubiquitously expressed in benign samples and significantly and coordinately reduced in pancreatic, gallbladder, and ampullary cancers.
  • Neither Fhit nor Wwox expression correlated with expression of other tumor suppressors or with clinicopathologic characteristics measured.
  • CONCLUSION: Loss of Fhit and Wwox expression does not predict tumor progression or patient survival, suggesting that loss of expression of genes at the exquisitely replication stress sensitive chromosome fragile regions is an early event in the pathogenesis of cancers of the gallbladder, pancreas, and ampulla.

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  • (PMID = 19434452.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA115965; United States / NCI NIH HHS / CA / R01 CA115965-03; United States / NCI NIH HHS / CA / CA133250-01; United States / NCI NIH HHS / CA / R01 CA132453-02; United States / NCI NIH HHS / CA / CA132453; United States / NCI NIH HHS / CA / K12 CA133250-01; United States / NCI NIH HHS / CA / K12 CA133250; United States / NCI NIH HHS / CA / CA132453-02; United States / NCI NIH HHS / CA / CA115965-03; United States / NCI NIH HHS / CA / CA133250; United States / NCI NIH HHS / CA / R01 CA115965; United States / NCI NIH HHS / CA / R01 CA132453
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 0 / fragile histidine triad protein; EC 1.- / Oxidoreductases; EC 1.1.1.- / WWOX protein, human; EC 3.6.- / Acid Anhydride Hydrolases
  • [Other-IDs] NLM/ NIHMS128319; NLM/ PMC2719793
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9. Lee JH, Lee KG, Ryou H, Jun YJ, Paik SS, Park HK, Lee KS: Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma. Hepatogastroenterology; 2010 May-Jun;57(99-100):646-52
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  • [Title] Significance analysis of histologic type and perineural invasion as prognostic factors after curative resection of ampulla of Vater carcinoma.
  • The influences of histologic type and perineural invasion on recurrence and survival in ampullar of Vater carcinoma still need to be assessed.
  • METHODOLOGY: We reviewed and analyzed the clinicopathologic data, surgical outcomes, recurrence and survival of 49 patients who received curative pancreatoduodenectomy for ampulla of Vater carcinoma at Hanyang University Hospital between July 1994 and June 2008.
  • Perineural invasion as well as tumor grade, T stage, lymph node metastasis, and lymphatic invasion were associated with survival (p < 0.05).
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Peripheral Nerves / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • (PMID = 20698243.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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10. Bogoevski D, Chayeb H, Cataldegirmen G, Schurr PG, Kaifi JT, Mann O, Yekebas EF, Izbicki JR: Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy. J Gastrointest Surg; 2008 Nov;12(11):1830-7; discussion 1837-8
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  • [Title] Nodal microinvolvement in patients with carcinoma of the papilla of vater receiving no adjuvant chemotherapy.
  • BACKGROUND: To assess the prognostic significance of nodal microinvolvement in patients with carcinoma of the papilla of Vater.
  • The vast majority of patients were operated upon pancreatic ductal adenocarcinoma (n = 566, 73%), followed by carcinomas of the papilla of Vater (n = 112, 14%), pancreatic neuroendocrine carcinomas (n = 39, 5%), intraductal papillary mucinous neoplasms (n = 33, 4%), and distal bile duct carcinomas (n = 27, 3%).
  • Fresh-frozen tissue sections from 169 lymph nodes (LNs) classified as tumor free by routine histopathology from 57 patients with R0 resected carcinoma of the papilla of Vater who had been spared from adjuvant chemotherapy were immunohistochemically (IHC) examined, using a sensitive IHC assay with the anti-epithelial monoclonal antibody Ber-EP4 for tumor cell detection.
  • RESULTS: Of the 169 "tumor-free" LNs, 91 LNs (53.8%) contained Ber-EP4-positive tumor cells.
  • CONCLUSIONS: The influence of occult tumor cell dissemination in LNs of patients with histologically proven carcinoma of the papilla of Vater supports the need for further tumor staging through immunohistochemistry.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Lymph Nodes / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle. Chemotherapy, Adjuvant. Cohort Studies. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Pancreatic Neoplasms / drug therapy. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Probability. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Analysis. Treatment Outcome

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  • (PMID = 18791769.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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11. van Oost FJ, Luiten EJ, van de Poll-Franse LV, Coebergh JW, van den Eijnden-van Raaij AJ: Outcome of surgical treatment of pancreatic, peri-ampullary and ampullary cancer diagnosed in the south of The Netherlands: a cancer registry based study. Eur J Surg Oncol; 2006 Jun;32(5):548-52
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  • [Title] Outcome of surgical treatment of pancreatic, peri-ampullary and ampullary cancer diagnosed in the south of The Netherlands: a cancer registry based study.
  • METHOD: The population-based Eindhoven Cancer Registry was used to select all patients in the CCCS area with pancreatic, peri-ampullary and ampullary cancer diagnosed between January 1, 1995 and April 30, 2000 (N = 1130).
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery. Registries
  • [MeSH-minor] Academic Medical Centers. Adult. Age Factors. Aged. Aged, 80 and over. Catchment Area (Health). Female. Hospitals, General. Hospitals, University. Humans. Male. Middle Aged. Needs Assessment. Neoplasm Staging. Netherlands. Population Surveillance. Referral and Consultation. Sex Factors. Social Class. Survival Rate. Treatment Outcome

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  • (PMID = 16569495.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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12. O'Connell JB, Maggard MA, Manunga J Jr, Tomlinson JS, Reber HA, Ko CY, Hines OJ: Survival after resection of ampullary carcinoma: a national population-based study. Ann Surg Oncol; 2008 Jul;15(7):1820-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival after resection of ampullary carcinoma: a national population-based study.
  • BACKGROUND: Ampullary cancer is the second most common periampullary cancer, with a resection and survival rate more favorable than that for pancreatic cancer.
  • Our objective was to complete a population-based analysis of patients undergoing resection for ampullary carcinoma and compare it with outcomes in the published literature.
  • METHODS: Patients diagnosed with ampullary cancer reported in the Surveillance, Epidemiology, and End Results program (1988-2003) were collected.
  • RESULTS: Of the 3292 ampullary cancer patients, 1301 (40%) underwent resection.
  • CONCLUSIONS: This is the largest population-based analysis of ampullary carcinoma.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Survival Analysis. Survival Rate. Treatment Outcome

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  • [CommentIn] Ann Surg Oncol. 2008 Jul;15(7):1813-4 [18425553.001]
  • (PMID = 18369675.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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13. Kucuk C, Artis T, Baskol M, Akgun H, Sozuer E: Diagnosis, treatment and prognosis of carcinoid tumour of the ampulla of Vater: long-term follow-up of a case. Acta Chir Belg; 2005 May-Jun;105(3):313-5
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  • [Title] Diagnosis, treatment and prognosis of carcinoid tumour of the ampulla of Vater: long-term follow-up of a case.
  • Carcinoid tumours of the ampulla of Vater are extremely rare.
  • In this report, we present a long-term follow-up of a new case with carcinoid tumour of the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / surgery

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  • (PMID = 16018528.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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14. Agarwal B, Gogia S, Eloubeidi MA, Correa AM, Ho L, Collins BT: Malignant mediastinal lymphadenopathy detected by staging EUS in patients with pancreaticobiliary cancer. Gastrointest Endosc; 2005 Jun;61(7):849-53
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  • METHODS: We retrospectively evaluated the presence of MML by EUS-guided FNA (EUS-FNA) in 160 consecutive patients with a definite diagnosis of pancreaticobiliary cancer (pancreatic and periampullary cancers) who underwent EUS-FNA by a single operator from 2000 to 2004.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Adult. Aged. Aged, 80 and over. Ampulla of Vater / pathology. Biopsy, Fine-Needle / methods. Common Bile Duct Neoplasms / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Neuroendocrine Tumors / pathology. Neuroendocrine Tumors / secondary. Positron-Emission Tomography. Retrospective Studies. Tomography, X-Ray Computed. Ultrasonography, Interventional

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  • (PMID = 15933686.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Kwak JW, Paik CN, Jung SH, Chang UI, Lee KM, Chung WC, Yoo JY, Yang JM: An inflammatory myofibroblastic tumor of the ampulla of vater successfully managed with endoscopic papillectomy: report of a case. Gut Liver; 2010 Sep;4(3):419-22
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  • [Title] An inflammatory myofibroblastic tumor of the ampulla of vater successfully managed with endoscopic papillectomy: report of a case.
  • The documented sites in the gastrointestinal tract include the esophagus, small intestine, colon, appendix, rectum, pancreas, spleen, liver, and Meckel's diverticulum.
  • Biliary IMTs are rare, and IMTs arising from the ampulla of Vater have not been reported previously.
  • Herein we report the case of a 65-year-old woman with an extrahepatic biliary obstruction due to IMT of the ampulla of Vater, and a successful therapeutic approach using endoscopic ultrasonography and endoscopic papillectomy.

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  • (PMID = 20981226.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2956361
  • [Keywords] NOTNLM ; Ampulla of Vater / Endoscopic papillectomy / Inflammatory myofibroblastic tumor
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16. Kim JH, Moon JH, Choi HJ, Lee HS, Kim HK, Cheon YK, Cho YD, Lee JS, Lee MS, Shim CS: Endoscopic snare papillectomy by using a balloon catheter for an unexposed ampullary adenoma with intraductal extension (with videos). Gastrointest Endosc; 2009 Jun;69(7):1404-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic snare papillectomy by using a balloon catheter for an unexposed ampullary adenoma with intraductal extension (with videos).
  • [MeSH-major] Adenoma / therapy. Ampulla of Vater. Common Bile Duct Neoplasms / therapy
  • [MeSH-minor] Aged. Catheterization. Duodenoscopy. Humans. Male. Neoplasm Invasiveness. Video Recording

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  • (PMID = 19152886.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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17. Giannopoulos G, Kavantzas N, Parasi A, Tiniakos D, Peros G, Tzanakis N, Patsouris E, Pavlakis K: Morphometric microvascular characteristics in the prognosis of pancreatic and ampullary carcinoma. Pancreas; 2007 Jul;35(1):47-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphometric microvascular characteristics in the prognosis of pancreatic and ampullary carcinoma.
  • OBJECTIVES: To evaluate multiple morphometric microvascular characteristics in addition to microvascular density (MVD) in pancreatic ductal and ampullary adenocarcinomas and provide a better approach in examining the relationship among angiogenesis, several clinicopathologic parameters, and prognosis.
  • METHODS: Histological sections from 32 pancreatic ductal and 17 ampullary adenocarcinomas, immunostained with CD34, were evaluated by image analysis for the quantification of MVD, total vascular area, and microvascular branching, as well as several morphometric parameters related to the vessel size and shape factor.
  • In the ampullary carcinoma group, higher shape factor values were observed in well-differentiated tumors.
  • The biologic behavior of the ampullary carcinomas does not seem to be dependent on any of the above mentioned factors of angiogenesis.
  • [MeSH-minor] Adult. Aged. Ampulla of Vater / blood supply. Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Antigens, CD34 / metabolism. Female. Humans. Kaplan-Meier Estimate. Lymph Nodes / metabolism. Lymph Nodes / pathology. Male. Microcirculation / pathology. Multivariate Analysis. Neoplasm Staging. Neovascularization, Pathologic / pathology. Pancreas / blood supply. Pancreas / metabolism. Pancreas / pathology. Pancreatic Ducts / blood supply. Pancreatic Ducts / metabolism. Pancreatic Ducts / pathology. Prognosis

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  • (PMID = 17575545.001).
  • [ISSN] 1536-4828
  • [Journal-full-title] Pancreas
  • [ISO-abbreviation] Pancreas
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34
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18. Chung YE, Kim MJ, Park MS, Choi JY, Kim H, Kim SK, Lee M, Kim HJ, Choi JS, Song SY, Kim KW: Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging. Radiology; 2010 Nov;257(2):384-93
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  • [Title] Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging.
  • PURPOSE: To define the differential imaging features of pancreatobiliary- and intestinal-type ampullary carcinomas at magnetic resonance (MR) imaging and to correlate these features with pathologic findings.
  • Fifty patients with surgically confirmed ampullary carcinoma and preoperative MR results were included.
  • CONCLUSION: An oval filling defect at the distal end of the bile duct on MRCP images and an extramural protruding appearance with a papillary surface at endoscopy are likely to suggest intestinal ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiopancreatography, Magnetic Resonance / methods. Common Bile Duct Neoplasms / diagnosis. Duodenal Neoplasms / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Diagnosis, Differential. Female. Humans. Image Interpretation, Computer-Assisted. Immunohistochemistry. Logistic Models. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate

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  • [Copyright] © RSNA, 2010.
  • (PMID = 20829529.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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19. Nakazawa K, Dobashi Y, Suzuki S, Fujii H, Takeda Y, Ooi A: Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol; 2005 Jul;206(3):356-65
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  • Overexpression of the tyrosine kinase receptor proteins was examined by immunohistochemistry in 221 biliary tract carcinomas, of which 28 were from the intrahepatic bile duct, 78 from the extrahepatic bile duct, 89 from the gall bladder, and 26 from the ampulla of Vater.
  • Overexpression of ErbB-2 was found in 15.7%, 11.5%, and 5.1% of carcinomas of the gall bladder, ampulla of Vater, and extrahepatic bile duct, respectively, and gene amplification was present in 79% of these.
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / pathology. Adult. Aged. Aged, 80 and over. Ampulla of Vater / pathology. Bile Duct Neoplasms / genetics. Bile Duct Neoplasms / pathology. Bile Ducts, Extrahepatic / pathology. Bile Ducts, Intrahepatic / pathology. Common Bile Duct Neoplasms / genetics. Common Bile Duct Neoplasms / pathology. Female. Gallbladder Neoplasms / genetics. Gallbladder Neoplasms / pathology. Gene Amplification / genetics. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry / methods. In Situ Hybridization, Fluorescence / methods. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Proteins / genetics

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  • [Copyright] Copyright 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 15892172.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.10.1 / Proto-Oncogene Proteins c-met; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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20. Zacharias T, Oussoultzoglou E, Jaeck D, Pessaux P, Bachellier P: Surgery for recurrence of periampullary malignancies. J Gastrointest Surg; 2009 Apr;13(4):760-7
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  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Pancreatic Neoplasms / surgery

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  • (PMID = 19050979.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Kalogeraki A, Tzardi M, Papadakis M, Stathopoulos E, Kouroumalis E, Zoras O: Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma. Acta Cytol; 2010 Jan-Feb;54(1):39-42
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  • [Title] Apoptosis and cell proliferation correlated with tumor grade in patients with ampullary carcinoma.
  • STUDY DESIGN: Forty patients (23 males and 17 females) aged 45-81 who underwent endoscopic retrograde cholangiopancreatography were diagnosed by cytology as having ampullary adenocarcinoma and the diagnoses were confirmed histologically after an operation.
  • RESULTS: The TUNEL indices were 0.4 +/- 0.07, 0.91 +/- 0.33 and 3.1 +/- 0.9 in well, moderate and poorly differentiated ampullary carcinoma, respectively.
  • The differences in both TUNEL and MIB-1 labeling indices were statistically significant between well, moderately and poorly differentiated ampullary carcinoma, and a positive correlation was found between TUNEL and the MIB-1 indices.
  • CONCLUSION: Apoptosis (cell death) and cell proliferation increase as the grade of the differentiation decreases in ampullary carcinoma, suggesting a rapid turnover of the tumor cells with lower grates of differentiation, and apoptosis may play an important role in the growth of the tumors in patients with ampullary carcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Apoptosis. Cell Proliferation. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Antinuclear / analysis. Antibodies, Monoclonal / analysis. DNA Fragmentation. Female. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 20306986.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody
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22. Uchiyama S, Chijiiwa K, Imamura N, Hiyoshi M, Ohuchida J, Nagano M, Nagaike K, Takahashi N, Akiyama Y: Adenoma of the major duodenal papilla with intraductal extension into the lower common bile duct. J Gastrointest Surg; 2008 Jun;12(6):1146-8
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  • Although benign and malignant tumors of the major duodenal papilla can be detected endoscopically, definitive diagnosis of such lesions by histologic examination of biopsy specimens is sometimes difficult, especially in cases with intraductal extension into the bile duct or pancreatic duct.
  • [MeSH-major] Adenoma / pathology. Ampulla of Vater. Common Bile Duct / pathology. Duodenal Neoplasms / pathology. Neoplasm Invasiveness. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laparotomy. Middle Aged

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  • (PMID = 17896165.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Kirimlioğlu H, Türkmen I, Başsüllü N, Dirican A, Karadağ N, Kirimlioğlu V: The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis. Turk J Gastroenterol; 2009 Mar;20(1):41-7
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  • [Title] The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.
  • Biliary neoplasms are classified into intra- and extrahepatic cholangiocarcinoma (Klatskin tumor, middle and distal extrahepatic tumors), gallbladder adenocarcinoma, and ampullary carcinoma.
  • METHODS: Ten gallbladder adenocarcinoma, 8 distal bile duct carcinomas (distal cholangiocarcinoma), 8 Klatskin tumors, 8 intrahepatic cholangiocarcinomas and 10 ampullary carcinomas were included in the study.
  • The tumor differentiation, angiolymphatic and perineural invasion of the tumor, and presence of lymph node and distant metastasis were determined.
  • RESULTS: The nontumoral epithelia of the gallbladder, intrahepatic ducts, and Klatskin tumor did not express MMP-2.
  • MMP-2 expression was detected in the distal part of the biliary ducts, in 75% (6/18) of cases and in the nontumoral epithelia of the ampullary region in 50% (5/10) of cases.
  • The metaplastic and dysplastic epithelia were positively stained in all of the gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary tumors.
  • The gallbladder adenocarcinoma, distal cholangiocarcinoma and ampullary carcinomas expressed MMP-2 in 30%, 37% and 40% of the cases, respectively.
  • Expressions of MMPs were higher in subjects with neural invasion, but there was no correlation between MMP expression and tumor differentiation or angiolymphatic invasion.
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Ampulla of Vater / enzymology. Ampulla of Vater / pathology. Disease Progression. Gallbladder Neoplasms / metabolism. Gallbladder Neoplasms / pathology. Hepatic Duct, Common / enzymology. Hepatic Duct, Common / pathology. Humans. Immunohistochemistry. Klatskin Tumor / metabolism. Klatskin Tumor / pathology. Matrix Metalloproteinase 14 / metabolism. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness. Prognosis

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  • (PMID = 19330734.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.80 / Matrix Metalloproteinase 14
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24. Georgescu SO, Neacşu CN, Vintilă D, Popa P, Florea N, Mihailovici MS: The histopathologic type of the periampullary tumors. Is it important for survival? Chirurgia (Bucur); 2009 Nov-Dec;104(6):697-700
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  • BACKGROUND: The ampulla of Vater is a junction with four histologic epithelial types: ampullary, duodenal, pancreatic and biliary.
  • Using our database we assessed the overall survival based on histologic type, tumor stage, lymph nodes involvement, tumor size and the level of differentiation.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Ampulla of Vater. Duodenal Neoplasms / mortality. Duodenal Neoplasms / pathology. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis. Male. Medical Records. Middle Aged. Multivariate Analysis. Neoplasm Staging. Pancreaticoduodenectomy / mortality. Prognosis. Proportional Hazards Models. Retrospective Studies. Romania / epidemiology. Survival Analysis. Treatment Outcome


25. Scélo G, Boffetta P, Hemminki K, Pukkala E, Olsen JH, Andersen A, Tracey E, Brewster DH, McBride ML, Kliewer EV, Tonita JM, Pompe-Kirn V, Chia KS, Jonasson JG, Martos C, Colin D, Brennan P: Associations between small intestine cancer and other primary cancers: an international population-based study. Int J Cancer; 2006 Jan 1;118(1):189-96
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  • Cancer of the small intestine is a rare neoplasm, and its etiology remains poorly understood.
  • Analysis of other primary cancers in individuals with small intestine cancer may help elucidate the causes of this neoplasm and the underlying mechanisms.
  • Significant (p < 0.05) increases were observed for cancers of the oropharynx, colon, rectum, ampulla of Vater, pancreas, corpus uteri, ovary, prostate, kidney, thyroid gland, skin and soft tissue sarcomas.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 16003748.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R03 CA101442-02
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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26. Yao HS, Wang Q, Wang WJ, Hu ZQ: Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis. World J Surg; 2008 Sep;32(9):2038-46
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  • [Title] Intraoperative allogeneic red blood cell transfusion in ampullary cancer outcome after curative pancreatoduodenectomy: a clinical study and meta-analysis.
  • This study examined whether intraoperative allogeneic RBC transfusion is an independent risk factor of adverse outcome in patients with ampullary carcinoma after curative pancreatoduodenectomy.
  • METHODS: The clinical data of 67 patients with carcinoma of the ampulla of Vatar underwent pancreatoduodenectomy between 1999 and 2004 were analyzed, and long-term follow-up visits were made for all patients.
  • For the meta-analysis, all English-language studies regarding blood transfusion from carcinoma of the ampulla of Vatar or ampullary carcinoma and prognostic factors or factors for survival from 1995 to 2007 were reviewed, and contingency tables were constructed from which a summary relative risk was calculated.
  • Forty-five patients (67.2%) died as a result of tumor progression.
  • After multivariate analysis, except for presence of lymph node metastasis (P = 0.023) and pancreatic invasion (P = 0.024), the intraoperative ABT > or =3 units was found to be an independent poor prognostic factor for those with ampullary cancer after curative pancreatoduodenectomy either (relative risk, 2.082; 95% confidence interval (CI), 1.048-4.135; P = 0.036).
  • CONCLUSIONS: The amount of intraoperative ABT is one of the important factors that adversely influenced survival in patients with ampullary cancer after curative pancreatoduodenectomy.
  • [MeSH-major] Ampulla of Vater / surgery. Erythrocyte Transfusion. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Blood Loss, Surgical. Blood Transfusion, Autologous. Chi-Square Distribution. Female. Humans. Intraoperative Care. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models. Risk Factors. Survival Analysis. Treatment Outcome

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  • (PMID = 18584239.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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27. Ajki T, Fujita T, Matsumoto I, Yasuda T, Fujino Y, Ueda T, Suzuki Y, Kuroda Y, Ku Y: Diagnostic and prognostic value of peritoneal cytology in biliary tract cancer. Hepatogastroenterology; 2008 May-Jun;55(84):842-5
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  • METHODOLOGY: A total of consecutive 41 patients with biliary cancers (17 bile duct, 20 gallbladder, 4 ampulla of Vater) underwent surgery between July 2003 and July 2005.
  • [MeSH-minor] Aged. Aged, 80 and over. Disease Progression. Female. Hepatectomy. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Pancreatectomy. Peritoneal Lavage. Prognosis

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  • (PMID = 18705279.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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28. Chang S, Lim JH, Choi D, Kim SK, Lee WJ: Differentiation of ampullary tumor from benign papillary stricture by thin-section multidetector CT. Abdom Imaging; 2008 Jul-Aug;33(4):457-62
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  • [Title] Differentiation of ampullary tumor from benign papillary stricture by thin-section multidetector CT.
  • The objective of this paper was to determine the criteria for differentiation of ampullary tumor from benign papillary stricture using thin-section multidetector CT images.
  • Multidetector CT images with 2.5 mm slice-thickness in 57 consecutive patients (24 with ampulla of Vater tumor and 33 with benign papillary stricture) with extrahepatic duct dilatation due to ampullary obstruction were reviewed retrospectively.
  • Multiple logistic regression analysis showed the papilla/papillary mass size was the only independently differentiating variable of ampullary tumor from benign stricture (P = 0.016) with an odds ratio of 2.424 (95% confidence interval, 1.179-4.903).
  • Ampullary tumor and benign papillary stricture could be effectively differentiated by thin-section multidetector CT based on papilla/papillary mass size.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Diseases / radiography. Common Bile Duct Neoplasms / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Constriction, Pathologic / radiography. Diagnosis, Differential. Female. Humans. Logistic Models. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 17712590.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Milsmann C, Füzesi L, Werner C, Becker H, Horstmann O: [Significance of occult lymphatic tumor spread in pancreatic cancer]. Chirurg; 2005 Nov;76(11):1064-72
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  • [Title] [Significance of occult lymphatic tumor spread in pancreatic cancer].
  • PURPOSE: The aim of this study was to determine the frequency and effect on prognosis of occult tumor cells in regional lymph nodes judged to be tumor-free in conventional histopathology of pancreatic cancer patients.
  • Archival paraffin blocks of 271 resected regional lymph nodes of 41 pN0 patients were reevaluated for occult tumor cells using monoclonal antibody Ber-EP4.
  • Cases with or without isolated tumor cells were compared regarding the distribution of various clinicopathological factors.
  • The occurrence of occult tumor cells was not dependent on other clinicopathological factors such as pT stage, grading, or curative resection.
  • Occult tumor cells impaired prognosis significantly in uni- and multivariate analyses (estimated 5-year survival 53% for pN0((i-)) vs 10% for pN0((i+)) and 9% for pN1/N2; P=0.0047).
  • CONCLUSION: Occult tumor cells are frequent in apparently tumor-free lymph nodes of pancreatic cancer patients and often overlooked in conventional histopathology.
  • Occult tumor cells in lymph nodes of pancreatic cancer patients could be used to stratify adjuvant therapy.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma, Ductal / surgery. Common Bile Duct Neoplasms / surgery. Lymph Node Excision. Lymphatic Metastasis / pathology. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Lymph Nodes / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Analysis

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  • (PMID = 15971035.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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30. Kim JH, Kim JH, Han JH, Yoo BM, Kim MW, Kim WH: Is endoscopic papillectomy safe for ampullary adenomas with high-grade dysplasia? Ann Surg Oncol; 2009 Sep;16(9):2547-54
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  • [Title] Is endoscopic papillectomy safe for ampullary adenomas with high-grade dysplasia?
  • OBJECTIVES: This study was designed to provide safe management guidelines for ampullary adenoma by analysis of clinicopathological features.
  • BACKGROUND: The treatment of ampullary cancer has been established; however, the indications for treatment of ampullary adenoma remain controversial.
  • METHODS: Between July 1997 and July 2008, a total of 33 patients were diagnosed with ampullary adenoma prior to procedures: 20 endoscopic papillectomies (ESP), 5 transduodenal resections (TDR), and 8 pancreatoduodenectomies (PD).
  • The size of tumor by final pathology was 1.27 +/- 0.89 cm in LGD, 1.81 +/- 0.99 cm in HGD, and 1.98 +/- 1.08 cm in cancer group.
  • There was a significant correlation between size of tumor and final pathology (P = 0.036).
  • According to receiver operating characteristic (ROC) curve, criterion to predict HGD/cancer was tumor size larger than 1.5 cm; sensitivity and specificity were 55.6% and 80.0%, respectively, and likelihood ratio was 2.778.
  • However, size of tumor was not associated with preprocedural pathology.
  • CONCLUSIONS: Ampullary adenoma with preprocedural HGD was highly associated with coexistence of cancer and recurrence.
  • Therefore, we suggest that ampullary adenoma with preprocedural HGD or more than 1.5 cm should not be managed with endoscopic papillectomy due to high associated rates of recurrence.
  • [MeSH-major] Adenoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Endoscopy, Gastrointestinal
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Pancreaticoduodenectomy. Prognosis. Survival Rate

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  • (PMID = 19568817.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Ishida M, Egawa S, Sakata N, Mikami Y, Motoi F, Abe T, Fukuyama S, Sunamura M, Furukawa T, Unno M: Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma. J Hepatobiliary Pancreat Surg; 2007;14(5):522-5
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  • [Title] Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma.
  • A 72-year-old woman, who had undergone pylorus-preserving pancreatoduodenectomy 3 years before for cancer of Vater's papilla associated with a branch-type intraductal papillary-mucinous adenoma (IPMA), developed dilatation of the main duct and a nodular lesion in the remnant pancreas.
  • Total pancreatectomy was performed, which revealed that the lesion was intraductal papillary-mucinous adenocarcinoma (IPMC) with minimal invasion, suggesting the metachronous multicentric occurrence of this intraductal papillary-mucinous neoplasm (IPMN).
  • [MeSH-major] Adenocarcinoma, Mucinous / surgery. Ampulla of Vater. Carcinoma, Pancreatic Ductal / diagnosis. Common Bile Duct Neoplasms / surgery. Neoplasms, Multiple Primary / diagnosis. Pancreatic Neoplasms / diagnosis

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  • (PMID = 17909725.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Kim SC, Kim SH, Myung SJ, Choi JW, Song MH, Jo YJ, Park YS, Joo JE, Park SW: [A case of intraductal papillary mucinous neoplasm of the pancreas arising from pancreas divisum without ventral pancreatic duct of Wirsung]. Korean J Gastroenterol; 2006 Mar;47(3):218-23
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  • [Title] [A case of intraductal papillary mucinous neoplasm of the pancreas arising from pancreas divisum without ventral pancreatic duct of Wirsung].
  • However, these cases are associated with incomplete type of pancreas divisum.
  • On endoscopic retrograde cholangiopancreatography, there was a severely bulging ampulla of Vater and patulous minor papilla draining mucinous material and a cystic lesion communicating with the dilated Santorini's duct without any communication with Wirsung's duct.
  • [MeSH-major] Carcinoma, Pancreatic Ductal. Pancreas / abnormalities. Pancreatic Ducts / abnormalities. Pancreatic Neoplasms

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  • (PMID = 16554676.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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33. Ni XG, Bai XF, Mao YL, Shao YF, Wu JX, Shan Y, Wang CF, Wang J, Tian YT, Liu Q, Xu DK, Zhao P: The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer. Eur J Surg Oncol; 2005 Mar;31(2):164-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The clinical value of serum CEA, CA19-9, and CA242 in the diagnosis and prognosis of pancreatic cancer.
  • AIM: Serum tumour markers carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and CA242 were investigated to evaluate the values of single and combined test in the diagnosis and prognosis of pancreatic cancer.
  • [MeSH-major] Antigens, Tumor-Associated, Carbohydrate / blood. Biomarkers, Tumor / blood. CA-19-9 Antigen / blood. Carcinoembryonic Antigen / blood. Carcinoma, Islet Cell / blood. Carcinoma, Islet Cell / diagnosis. Pancreatic Neoplasms / blood. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Ampulla of Vater / metabolism. Ampulla of Vater / pathology. Bile Duct Neoplasms / blood. Bile Duct Neoplasms / diagnosis. Bile Duct Neoplasms / surgery. Bile Ducts, Extrahepatic / metabolism. Bile Ducts, Extrahepatic / pathology. Bilirubin / blood. Cholangiocarcinoma / blood. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / surgery. Female. Humans. Male. Middle Aged. Neoplasm Staging. Pancreaticoduodenectomy. Prognosis. Sensitivity and Specificity. Statistics as Topic. Survival Analysis. Treatment Outcome

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  • (PMID = 15698733.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Tumor-Associated, Carbohydrate; 0 / Biomarkers, Tumor; 0 / CA 242 antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; RFM9X3LJ49 / Bilirubin
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34. Hsu HP, Shan YS, Lai MD, Lin PW: Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival. Cancer Biol Ther; 2010 Jul 15;10(2):144-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival.
  • PURPOSE: Tumor-associated macrophages (TAMs) promote cancer cell proliferation and distant metastases.
  • RESULTS: In 100 ampullary cancers, diffuse cytoplasmic positivity for OPN was found in infiltrating TAMs in 36 patients and marginal TAMs in 32 patients; OPN(+) macrophages were absent in 32 patients.
  • Expression patterns of OPN in TAMs were associated with pancreatic invasion, tumor stage, TNM stage, lymphovascular invasion and recurrence with peritoneal carcinomatosis.
  • Patients were stratified according to a median tumor size of 2 cm.
  • Patients with tumor sizes ≥2 cm and OPN(+) infiltrating TAMs had a poorer disease-specific survival rate than those with OPN(+) marginal TAMs.
  • Macrophage-associated cytokine expression in ampullary cancer cells was also assessed; levels of macrophage migration inhibitory factor (MIF) in cancer cells were higher than in normal duodenal mucosa.
  • EXPERIMENTAL DESIGN: Specimens from ampullary cancer patients at National Cheng Kung University Hospital were collected for immunohistochemistry.
  • Tumor and normal epithelial cells from fresh tissues were separated by laser-assisted microdissection for reverse-transcription polymerase chain reaction and quantitative real-time PCR analyses.
  • CONCLUSIONS: Expression of OPN and location of TAMs in bulky ampullary cancer predict recurrence.
  • In addition, cytoplasmic staining of MIF is enhanced in ampullary cancer cells.
  • Patients with bulky tumor, OPN(+) infiltrating TAMs and MIF expression had a worst disease-specific survival.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Biomarkers, Tumor / metabolism. Common Bile Duct Neoplasms / pathology. Macrophage Migration-Inhibitory Factors / metabolism. Macrophages / metabolism. Osteopontin / metabolism. RNA, Neoplasm / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Recurrence. Retrospective Studies. Statistics, Nonparametric. Survival Analysis. Tumor Burden

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  • (PMID = 20495367.001).
  • [ISSN] 1555-8576
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Macrophage Migration-Inhibitory Factors; 0 / RNA, Neoplasm; 106441-73-0 / Osteopontin
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35. Fathy O, Wahab MA, Elghwalby N, Sultan A, EL-Ebidy G, Hak NG, Abu Zeid M, Abd-Allah T, El-Shobary M, Fouad A, Kandeel T, Abo Elenien A, Abd El-Raouf A, Hamdy E, Sultan AM, Hamdy E, Ezzat F: 216 cases of pancreaticoduodenectomy: risk factors for postoperative complications. Hepatogastroenterology; 2008 May-Jun;55(84):1093-8
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  • Periampullary adenocarcinoma was found in 204 (94.4%) patients, chronic pancreatitis in 9 (4.2%) patients, 2 patients with solid and papillary neoplasm, and 1 patient with NHL (Non-Hodgkin's Lymphoma).
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy. Postoperative Complications / etiology

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  • (PMID = 18705336.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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36. Hurtuk MG, Hughes C, Shoup M, Aranha GV: Does lymph node ratio impact survival in resected periampullary malignancies? Am J Surg; 2009 Mar;197(3):348-52
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  • RESULTS: Of the 364 malignancies identified, there were 219 (60%) pancreatic adenocarcinomas, 36 (10%) duodenal adenocarcinomas, 75 (21%) ampullary adenocarcinomas, and 35 (10%) cholangiocarcinomas.
  • LNR is inversely associated with survival rates in pancreatic and ampullary adenocarcinoma patients.
  • [MeSH-minor] Abdomen. Adult. Aged. Aged, 80 and over. Ampulla of Vater. Cholangiocarcinoma / mortality. Cholangiocarcinoma / pathology. Cholangiocarcinoma / surgery. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Duodenal Neoplasms / mortality. Duodenal Neoplasms / pathology. Duodenal Neoplasms / surgery. Female. Humans. Liver Neoplasms / mortality. Liver Neoplasms / pathology. Liver Neoplasms / surgery. Male. Middle Aged. Neoplasm Staging. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / pathology. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy. Retrospective Studies. Survival Analysis

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  • (PMID = 19245913.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Harewood GC, Pochron NL, Gostout CJ: Prospective, randomized, controlled trial of prophylactic pancreatic stent placement for endoscopic snare excision of the duodenal ampulla. Gastrointest Endosc; 2005 Sep;62(3):367-70
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  • [Title] Prospective, randomized, controlled trial of prophylactic pancreatic stent placement for endoscopic snare excision of the duodenal ampulla.
  • [MeSH-major] Ampulla of Vater / surgery. Pancreatic Ducts / surgery. Pancreatic Neoplasms / surgery. Pancreatitis / prevention & control. Sphincterotomy, Endoscopic / methods. Stents
  • [MeSH-minor] Adult. Aged. Cholangiopancreatography, Endoscopic Retrograde / methods. Female. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures / methods. Neoplasm Staging. Postoperative Complications / prevention & control. Probability. Prognosis. Prospective Studies. Risk Assessment. Survival Rate. Treatment Outcome

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  • [CommentIn] Gastrointest Endosc. 2005 Sep;62(3):371-3 [16111954.001]
  • (PMID = 16111953.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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38. Katsinelos P, Kountouras J, Chatzimavroudis G, Zavos C, Paroutoglou G, Kotakidou R, Panagiotopoulou K, Papaziogas B: A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection. Surg Laparosc Endosc Percutan Tech; 2007 Dec;17(6):533-7
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  • [Title] A case of early depressed-type ampullary carcinoma treated by wire-guided endoscopic resection.
  • Endoscopic cholangiopancreatography revealed a depressed-type carcinoma at the ampulla of Vater and dilation of both the common bile and pancreatic ducts without intraductal filling defects.
  • Intraductal ultrasonography showed a hypoechoic mass limited to the ampulla of Vater.
  • Histologic examination of the resected specimen showed a completely excised well-differentiated adenocarcinoma limited to the ampulla of Vater.
  • Both accurate preoperative staging and proper histologic evaluation of the resected specimen seem to justify endoscopic treatment of early ampullary cancer by an experienced endoscopist.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Sphincterotomy, Endoscopic / methods
  • [MeSH-minor] Aged. Cholangiopancreatography, Endoscopic Retrograde. Endosonography. Humans. Male. Neoplasm Staging. Treatment Outcome

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  • (PMID = 18097317.001).
  • [ISSN] 1530-4515
  • [Journal-full-title] Surgical laparoscopy, endoscopy & percutaneous techniques
  • [ISO-abbreviation] Surg Laparosc Endosc Percutan Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Sakorafas GH, Giannopoulos GA, Parasi A, Konstantoudakis G, Tzanakis N, Stergiopoulos S, Peros G: Large somatostatin-producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease. Case report and review of the literature. JOP; 2008;9(5):633-9
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  • [Title] Large somatostatin-producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease. Case report and review of the literature.
  • CASE REPORT: We present the case of a 49-year-old female patient with von Recklinghausen's disease and an incidentally diagnosed ampullary neoplasm.
  • Histology and immunohistochemistry showed that the duodenal tumor was an ampullary somatostatin-producing endocrine carcinoma while the gastric tumor was a gastrointestinal stromal tumor (GIST).
  • The postoperative course was uneventful and the patient is alive, without tumor recurrence, six years after surgery.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / complications. Gastrointestinal Stromal Tumors / complications. Neurofibromatosis 1 / complications. Somatostatinoma / complications
  • [MeSH-minor] Female. Humans. Middle Aged. Somatostatin / secretion. Tumor Burden

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  • (PMID = 18762695.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 51110-01-1 / Somatostatin
  • [Number-of-references] 28
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40. Nassar H, Albores-Saavedra J, Klimstra DS: High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol; 2005 May;29(5):588-94
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  • [Title] High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases.
  • We describe the clinical and pathologic features of 14 cases of high-grade neuroendocrine carcinoma (HGNEC) of the ampulla of Vater classified according to WHO classification of lung tumors into small cell carcinoma (SCC, 6 cases) and large cell neuroendocrine carcinoma (LCNEC, 8 cases) types.
  • The immunohistochemical findings were compared with those of 13 cases of primary poorly differentiated ampullary adenocarcinomas (PDACA) lacking neuroendocrine morphology.
  • The mean tumor size was 2.5 cm.
  • Overall, 64% of patients with ampullary HGNEC died of disease (mean follow-up, 14.5 months).
  • In conclusion, HGNECs of the ampulla are rare (2%-3% of ampullary tumors in our material).
  • The clinical course parallels that of their pulmonary counterparts and appears to be worse than that of locally advanced ampullary adenocarcinomas.
  • Loss of Rb expression, a characteristic finding in pulmonary SCCs, is present in almost half of ampullary HGNECs.
  • Thus, there are differences in the molecular phenotypes of these two types of ampullary carcinoma, supporting the distinction of poorly differentiated carcinomas with a neuroendocrine phenotype from those without.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma, Neuroendocrine / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / chemistry. Adenocarcinoma / pathology. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Survival Rate

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  • (PMID = 15832081.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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41. Parini U, Nardi M Jr, Loffredo A, Fabozzi M, Roveroni M: Laparoscopic resection of duodenal gangliocytic paraganglioma. A case report. Chir Ital; 2007 Jul-Aug;59(4):551-8
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  • Paraganglioma is an exceedingly rare tumour of the duodenum that arises in close proximity to the ampulla of Vater.
  • This neoplasm generally behaves in a benign fashion, although instances of recurrence and/or lymph node metastasis have been described.
  • The treatment consists in endoscopic polypectomy or surgical resection in relation to the histological features and the macroscopic extent of the neoplasm.
  • Upper gastrointestinal endoscopy followed by enteroscopy with a video-capsula, revealed a pedunculated neoplasm in the second portion of the duodenum, with ulceration of the overlying mucosa.
  • After stabilisation of the patient's clinical status, we performed a resection of the neoplasm via a laparoscopic transduodenal approach and a concomitant intraoperative duodenoscopy.
  • The size of the neoplasm was 4 cm.
  • The patient is currently in good health without any tumour recurrence.
  • This approach affords the advantages of the minimally invasive technique and fulfils the surgical tenets of the open transduodenal approach, if en bloc resection of the neoplasm with the adjacent duodenal wall is performed.

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  • (PMID = 17966779.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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42. Leung VK, Lee SW, Yuen NW, Kung NN, Loke TK: Epigastric pain in a patient with neurofibromatosis type 1. Hong Kong Med J; 2005 Jun;11(3):213-5
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  • Patients with neurofibromatosis type 1 are at increased risk of developing carcinoid tumours of the duodenum, particularly in the ampulla of Vater.
  • Aggressive surgery with pancreatoduodenectomy is recommended for all ampullary carcinoid tumours because of their propensity to metastasise.
  • Evaluation using magnetic resonance cholangiopancreatography and side-viewing duodenoscopy revealed a submucosal tumour at the ampulla of Vater causing pancreatobiliary ductal obstruction and dilation.
  • The ampullary tumour was overlooked initially by forward-viewing endoscopy.
  • Histological examination of the surgically resected specimen confirmed the presence of a carcinoid tumour, with metastasis to peri-pancreatic lymph nodes.


43. Kelemen D, Papp R, Baracs J, Káposztás Z, Al-Farhat Y, Horváth OP: [Treatment of pancreatic and periampullary tumours in our department in the last 10 years]. Magy Seb; 2009 Oct;62(5):287-92
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  • [Transliterated title] Pancreas- és periampullaris tumorok kezelése az elmúlt 10 évben klinikánkon.
  • The preoperative data (age, gender, site of the tumour, characteristic clinical signs), as well as surgical methods are overviewed.
  • [MeSH-major] Ampulla of Vater. Digestive System Surgical Procedures / adverse effects. Digestive System Surgical Procedures / methods. Palliative Care. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Pancreatectomy / adverse effects. Pancreatectomy / methods. Pancreatic Fistula / etiology. Pancreaticoduodenectomy / adverse effects. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 19828417.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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44. Santini D, Baldi A, Vincenzi B, Mellone P, Campioni M, Antinori A, Borzomati D, Coppola R, Magistrelli P, Tonini G: Mucin 2 (MUC2) and mucin 5 (MUC5) expression is not associated with prognosis in patients with radically resected ampullary carcinoma. J Clin Pathol; 2007 Sep;60(9):1069-70
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  • [Title] Mucin 2 (MUC2) and mucin 5 (MUC5) expression is not associated with prognosis in patients with radically resected ampullary carcinoma.
  • [MeSH-major] Ampulla of Vater. Biomarkers, Tumor / metabolism. Common Bile Duct Neoplasms / metabolism. Mucins / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Mucin-2. Mucin-5B. Neoplasm Proteins / metabolism. Prognosis. Survival Analysis

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  • [Cites] Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):77-99 [15000151.001]
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  • (PMID = 17761747.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / MUC2 protein, human; 0 / MUC5B protein, human; 0 / Mucin-2; 0 / Mucin-5B; 0 / Mucins; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ PMC1972431
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45. Jerraya H, Bel Haj Salah R, Ben Mena K, Haouet K, Zaouche A: Stromal tumor of the ampulla of vater: report of a case and systematic review of reported cases. Tunis Med; 2009 Sep;87(9):556-9
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  • [Title] Stromal tumor of the ampulla of vater: report of a case and systematic review of reported cases.
  • The localization of stromal tumours in the ampulla of Vater (STAV) is very rare.
  • Key words used were "ampulla of Vater" and "Gastrointestinal stromal tumor" and "CD 117".
  • STAV is a tumor of adult after the age of fifty.
  • Gastroduodenal endoscopy with biopsies and immunoassaying allows positive preoperative diagnosis in the 5 cases.
  • Treatment should be duodenopancreatectomy since the tumor is often malignant (5 cases).
  • [MeSH-major] Ampulla of Vater. Gastrointestinal Stromal Tumors

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  • (PMID = 20180372.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] Tunisia
  • [Number-of-references] 13
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46. Park JE, Dong SH, Cho KH, Jang JY, Kim HJ, Kim BH, Chang YW, Chang R: [Successful resection of locally advanced gastrointestinal stromal tumor of the ampulla of Vater after treatment with imatinib]. Korean J Gastroenterol; 2010 Jul;56(1):39-44
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  • [Title] [Successful resection of locally advanced gastrointestinal stromal tumor of the ampulla of Vater after treatment with imatinib].
  • Gastrointestinal stromal tumor (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract arising from Cajal's cells, expressing CD 117.
  • We report a case of unresectable primary GIST of the ampulla of Vater, which we were able to completely resect after treatment with a dosage of imatinib 400 mg daily for 5 months.
  • [MeSH-major] Ampulla of Vater / pathology. Antineoplastic Agents / therapeutic use. Gastrointestinal Stromal Tumors / surgery. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 20695129.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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47. Santini D, Perrone G, Vincenzi B, Lai R, Cass C, Alloni R, Rabitti C, Antinori A, Vecchio F, Morini S, Magistrelli P, Coppola R, Mackey JR, Tonini G: Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer. Ann Oncol; 2008 Apr;19(4):724-8
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  • [Title] Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer.
  • Moreover, recent reports indicate a significant correlation between immunohistochemical variations of hENT1 in tumor samples and survival after gemcitabine therapy in patients with solid tumors.
  • MATERIALS AND METHODS: We used immunohistochemistry to assess the abundance and distribution of hENT1 in tumor samples from radically resected cancer of the ampulla, and sought correlations between immunohistochemical results and clinical parameters including disease outcomes.
  • No statistical significant differences were found between immunohistochemical findings and patient characteristics (sex, age, and tumor-node-metastasis).
  • CONCLUSIONS: hENT1 expression is a molecular prognostic marker for patients with resected ampullary cancer and holds promise as a predictive factor to assist in chemotherapy decisions.

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  • (PMID = 18187485.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Equilibrative Nucleoside Transporter 1; 0 / Ki-67 Antigen; 0 / SLC29A1 protein, human
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48. Manta R, Conigliaro R, Castellani D, Messerotti A, Bertani H, Sabatino G, Vetruccio E, Losi L, Villanacci V, Bassotti G: Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors. World J Gastroenterol; 2010 Nov 28;16(44):5592-7
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  • [Title] Linear endoscopic ultrasonography vs magnetic resonance imaging in ampullary tumors.
  • AIM: To assess linear endoscopic ultrasound (L-EUS) and magnetic resonance imaging (MRI) in biliary tract dilation and suspect small ampullary tumor.
  • METHODS: L-EUS and MRI data were compared in 24 patients with small ampullary tumors; all with subsequent histological confirmation.
  • RESULTS: A suspicion of ampullary tumor was present in 75% of MRI and all L-EUS examinations, with 80% agreement between EUS and histological findings at endoscopy.
  • CONCLUSION: L-EUS could be a useful adjunct as a diagnostic tool in the evaluation of patients with suspected ampullary tumors.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma / diagnosis. Ampulla of Vater / pathology. Ampulla of Vater / ultrasonography. Common Bile Duct Neoplasms / diagnosis. Endosonography. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Male. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 21105192.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2992677
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49. Matsuzawa G, Shirabe K, Gion T, Tsujita E, Ooya M, Kajiyama K, Nagaie T: Surgically resected undifferentiated carcinoma with osteoclast-like giant cells of the periampullary region involving the orifice of the papilla of Vater: Report of a case. Surg Today; 2010 Apr;40(4):376-9
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  • [Title] Surgically resected undifferentiated carcinoma with osteoclast-like giant cells of the periampullary region involving the orifice of the papilla of Vater: Report of a case.
  • We report the case of a 71-year-old man with periampullary carcinoma who underwent pancreaticoduodenectomy under the diagnosis of periampullary carcinoma.
  • Histologically, the neoplasm was composed of undifferentiated cells and evenly spaced osteoclast-like giant cells.
  • [MeSH-major] Ampulla of Vater. Carcinoma / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 20339995.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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50. Suzuki S, Tanaka S, Hayashi T, Harada N, Suzuki M, Hanyu F, Ban S: Small-cell neuroendocrine carcinoma of the ampulla of Vater. J Hepatobiliary Pancreat Surg; 2006;13(5):450-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small-cell neuroendocrine carcinoma of the ampulla of Vater.
  • Postoperative magnetic resonance cholangiopancreatography, cholangiography, and upper gastroduodenal endoscopy showed a tumor of the ampulla of Vater, and pylorus-preserving pancreatoduodenectomy was performed.
  • Histology of the resected tumor was that of small-cell carcinoma, and immunohistochemistry showed positive staining for neuron-specific enolase, chromogranin A, and synaptophysin, confirming the neuroendocrine nature of the tumor.
  • As the histology of the tumor was distinct from cecal carcinoma, and no tumors were found in other organs, the tumor was diagnosed as primary small-cell neuroendocrine carcinoma of the ampulla of Vater.
  • The patient died due to multiple liver metastases of the carcinoma of the ampulla of Vater 7 months after the pancreatoduodenectomy.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Neuroendocrine / pathology. Carcinoma, Small Cell / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 17013721.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Casaretto E, Andrada DG, Granero LE: [Results of cephalic pancreaticoduodenectomy for ampullary carcinoma. Analysis of 18 consecutive cases]. Acta Gastroenterol Latinoam; 2010 Mar;40(1):22-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Results of cephalic pancreaticoduodenectomy for ampullary carcinoma. Analysis of 18 consecutive cases].
  • [Transliterated title] Resultados de la duodenopancreatectomía cefálica en el tratamiento del carcinoma de la ampolla de vater. Análisis de 18 casos consecutivos.
  • BACKGROUND: Complete resection offers the only potential cure for ampullary carcinoma.
  • AIM: The aim of this study was to assess the results of cephalic pancreaticoduodenectomy for patients with ampullary carcinoma based on mortality, hospital morbidity, late morbidity, and survival.
  • PATIENTS AND METHODS: We retrospectively and prospectively reviewed all patients who underwent cephalic pancreaticoduodenectomy, between October 1994 and October 2006 for ampullary carcinoma.
  • The tumor was unresectable in the remaining 2 patients.
  • Resection margins were tumor free (RO) in all patients.
  • CONCLUSIONS: Cephalic pancreaticoduodenectomy is the surgical procedure of choice for ampullary carcinoma, with low hospital mortality, and the best chance for cure in patients with node-negative disease.
  • [MeSH-major] Ampulla of Vater. Carcinoma / surgery. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Prospective Studies. Retrospective Studies. Treatment Failure

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  • (PMID = 20446393.001).
  • [ISSN] 0300-9033
  • [Journal-full-title] Acta gastroenterologica Latinoamericana
  • [ISO-abbreviation] Acta Gastroenterol. Latinoam.
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Argentina
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52. Pamukcuoglu M, Oksuzoglu B, Abali H, Akoglu M, Atalay F, Budakoglu B, Uncu D, Ozdemir NY, Guler T, Zengin N: Prognostic factors and clinicopathological characteristics of carcinoma of ampulla Vateri. Int Surg; 2008 Jul-Aug;93(4):214-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors and clinicopathological characteristics of carcinoma of ampulla Vateri.
  • The aim of this study was to describe the clinicopathological characteristics and prognostic factors of carcinoma of ampulla Vateri.
  • ECOG performance status (P = 0.06), stage (P = 0.05), perineural invasion (P = 0.01), tumor grade (P = 0.01), and treatment with chemotherapy, chemoradiotherapy, or only radiotherapy (P = 0.001) had a statistically significant impact on overall survival, whereas only tumor histopathology (P < 0.001) was shown to have a statistically significant effect on disease-free survival.
  • Carcinoma of ampulla Vateri is a rare gastrointestinal tumor.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies

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  • (PMID = 19731856.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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53. Hopper AD, Bourke MJ, Williams SJ, Swan MP: Giant laterally spreading tumors of the papilla: endoscopic features, resection technique, and outcome (with videos). Gastrointest Endosc; 2010 May;71(6):967-75
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  • Outcomes were compared with those of conventional ampullary adenoma resection during the same period.
  • RESULTS: Twenty-five patients with ampullary adenomas were referred.
  • Complication and recurrence rates in smaller (<30 mm) ampullary adenoma resections were not significantly different.
  • In experienced hands, the outcomes are comparable to those for conventional ampullary adenomas.
  • [MeSH-major] Adenoma / diagnosis. Adenoma / surgery. Ampulla of Vater. Duodenal Neoplasms / diagnosis. Duodenal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Duodenoscopy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Video Recording

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  • [Copyright] 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • [CommentIn] Endoscopy. 2011 Jan;43(1):42-6 [21234840.001]
  • (PMID = 20226451.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Hsu SD, Chan DC, Hsieh HF, Chen TW, Yu JC, Chou SJ: Ectopic pancreas presenting as ampulla of Vater tumor. Am J Surg; 2008 Apr;195(4):498-500
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  • [Title] Ectopic pancreas presenting as ampulla of Vater tumor.
  • Ectopic pancreas is relatively rare and is defined as pancreatic tissue that is situated abnormally, has no contact with the normal pancreas, and has its own ductal system and blood supply.
  • Most patients with an ectopic pancreas are asymptomatic, and, if present, symptoms are nonspecific and depend on the site of the lesion and the different complications encountered.
  • Herein, we report a patient presenting with symptoms of ampullary tumor with obstructive jaundice, but the imaging study did not suggest the possibility of ectopic pancreas preoperatively.
  • [MeSH-major] Ampulla of Vater. Choristoma / diagnosis. Common Bile Duct Diseases / diagnosis. Pancreas
  • [MeSH-minor] Cholangiopancreatography, Endoscopic Retrograde. Common Bile Duct Neoplasms / diagnosis. Diagnosis, Differential. Humans. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18304504.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Moriya T, Kimura W, Hirai I, Mizutani M, Yamamoto T, Toya R, Kamiga M, Fuse A: Twelve years survival with repeated hepatectomy and lung resection for metastasis from carcinoma of the papilla of Vater after pancreaticoduodenectomy. Hepatogastroenterology; 2007 Sep;54(78):1652-4
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  • [Title] Twelve years survival with repeated hepatectomy and lung resection for metastasis from carcinoma of the papilla of Vater after pancreaticoduodenectomy.
  • We present a 60-year-old woman who underwent three times hepatectomy and lung resection for metastasis originating from a carcinoma of the papilla of Vater after pancreaticoduodenectomy with lymphadenectomy during 12 years.
  • Pancreaticoduodenectomy was performed in 1980 and histological examination of original tumor revealed a stage IIA papillary adenocarcinoma (pT3, pN0, pM0).
  • The current case is very rare, however, if patients with carcinoma of the papilla of Vater have localized liver metastases and no local recurrence, liver metastases should be resected to improve the chances for long-term survival.
  • [MeSH-major] Ampulla of Vater / surgery. Carcinoma / surgery. Carcinoma / therapy. Common Bile Duct Neoplasms / surgery. Common Bile Duct Neoplasms / therapy. Hepatectomy / methods. Lung / surgery. Lung Neoplasms / secondary. Pancreaticoduodenectomy / methods
  • [MeSH-minor] Adenocarcinoma, Papillary / surgery. Female. Humans. Middle Aged. Neoplasm Metastasis. Time Factors. Treatment Outcome

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  • (PMID = 18019686.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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56. Lagoudianakis EE, Tsekouras D, Koronakis N, Chrysicos J, Archontovasilis F, Filis K, Katergiannakis V, Manouras A: A prospective comparison of ampullectomy with pancreaticoduodenectomy for the treatment of periampullary cancer. J BUON; 2008 Oct-Dec;13(4):569-72
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  • The aim of our study was to compare local excision (LE) of the ampulla with standard pancreaticoduodenectomy (PD) for the treatment of periampullary cancer in terms of overall survival.
  • Inclusion criteria were primary tumor < or = 2 cm with no evidence of lymph node involvement or distant metastasis on abdominal computed tomography (CT).
  • The two groups were homogeneous with respect to age and gender as well as the size and origin of the primary neoplasm.
  • There was no correlation of the survival with age, gender, presence of lymph node metastasis, size of the primary tumor, type of surgery or histologic grade (x(2), p >0.05).
  • However, the origin of the tumor had major impact on survival, with pancreatic tumors having the worst prognosis.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery

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  • [ErratumIn] J BUON. 2009 Oct-Dec;14(4):737
  • (PMID = 19145682.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
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57. Hustinx SR, Fukushima N, Zahurak ML, Riall TS, Maitra A, Brosens L, Cameron JL, Yeo CJ, Offerhaus GJ, Hruban RH, Goggins M: Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms. Cancer Biol Ther; 2005 May;4(5):596-601
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  • We investigated the prognostic significance of aberrant expression of 14-3-3sigma and the ERM proteins (Ezrin, radixin, Moesin) in a series of invasive periampullary adenocarcinomas including 300 infiltrating pancreatic adenocarcinomas, 54 ampullary adenocarcinomas, and 33 noninvasive intraductal papillary mucinous neoplasms from patients who underwent pancreaticoduodenal resection at The Johns Hopkins Hospital, Baltimore, MD, between 1991 and 2003.
  • Two-hundred fourty-four (82%) primary infiltrating adenocarcinomas of the pancreas demonstrated positive expression of the 14-3-3sigma, 45 (15%) showed weak immunolabelling, and 9 (3%) were negative.
  • A similar proportion of ampullary cancers showed 14-3-3sigma and ERM protein expression.
  • [MeSH-major] Ampulla of Vater / metabolism. Biomarkers, Tumor / metabolism. Common Bile Duct Diseases / metabolism. DNA-Binding Proteins / metabolism. Exonucleases / metabolism. Neoplasm Proteins / metabolism. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / metabolism. Transcription Factors / metabolism

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  • (PMID = 15908786.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 14-3-3 Proteins; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / ETV5 protein, human; 0 / Neoplasm Proteins; 0 / Transcription Factors; EC 3.1.- / Exonucleases; EC 3.1.- / Exoribonucleases; EC 3.1.- / SFN protein, human
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58. Chang SK, Liang WT, Thamboo TP: Inflammatory pseudotumour arising from periampullary carcinoid: a "cancer-like" tumour in a "fake" tumour. Singapore Med J; 2009 Mar;50(3):e100-1
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  • [Title] Inflammatory pseudotumour arising from periampullary carcinoid: a "cancer-like" tumour in a "fake" tumour.
  • We present a 52-year-old Chinese woman with a carcinoid at the ampulla of Vater, a site far less common than other areas of the gastrointestinal tract.
  • An intraoperative biopsy of the enlarged nodes was negative for malignancy and postoperative histology of the large pancreatic mass yielded a surprising finding of a carcinoid tumour at the ampulla of Vater with a large inflammatory pancreatic mass adherent to the portal vein.
  • This is an uncommon case associated with "pseudotumour pancreatitis", causing biliary and pancreatic duct obstruction mimicking a large tumour in the head of the pancreas.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoid Tumor / complications. Gallbladder Neoplasms / complications. Granuloma, Plasma Cell / etiology

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  • (PMID = 19352550.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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59. Carter JT, Grenert JP, Rubenstein L, Stewart L, Way LW: Tumors of the ampulla of vater: histopathologic classification and predictors of survival. J Am Coll Surg; 2008 Aug;207(2):210-8
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  • [Title] Tumors of the ampulla of vater: histopathologic classification and predictors of survival.
  • BACKGROUND: The histology and clinical behavior of ampullary tumors vary substantially.
  • We speculated that this might reflect the presence of two kinds of ampullary adenocarcinoma: pancreaticobiliary and intestinal.
  • STUDY DESIGN: We analyzed patient demographics, presentation, survival (mean followup 44 months), and tumor histology for 157 consecutive ampullary tumors resected from 1989 to 2006.
  • Size of tumor did not predict survival, nor did cribriform/papillary features, dirty necrosis, apical mucin, or nuclear atypia.
  • Patients with pancreaticobiliary ampullary adenocarcinomas presented with jaundice more often than those with the intestinal kind (p = 0.01) and had worse survival.
  • CONCLUSIONS: In addition to other factors, tumor type (intestinal versus pancreaticobiliary) had a major effect on survival in patients with ampullary adenocarcinoma.
  • The current concept of ampullary adenocarcinoma as a unique entity, distinct from duodenal and pancreatic adenocarcinoma, might be wrong.
  • Intestinal ampullary adenocarcinomas behaved like their duodenal counterparts, but pancreaticobiliary ones were more aggressive and behaved like pancreatic adenocarcinomas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Female. Follow-Up Studies. Humans. Jaundice, Obstructive / mortality. Jaundice, Obstructive / pathology. Jaundice, Obstructive / surgery. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Retrospective Studies. Risk Factors

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  • (PMID = 18656049.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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60. Molnár G, Iancu C, Munteanu D, Muntean V, Al Hajjarz N, Bălă O, Vlad L: [The role of diagnostic laparoscopy in periampullary and pancreatic cancers. A study based on 27 cases]. Chirurgia (Bucur); 2010 May-Jun;105(3):383-6
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  • [Transliterated title] Rolul laparoscopiei diagnostice în cancerele periampulare şi pancreatice. studiu bazat pe un număr de 27 cazuri.
  • BACKGROUND: Starting from the premise that abdominal tumours require very accurate assessment and staging, the study "DIASTAL" (laparoscopic diagnosis and staging of abdominal tumours) proposed to establish the effectiveness of laparoscopy in the diagnosis and resectability of these neoplasms.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Laparoscopy. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Palliative Care. Predictive Value of Tests. Prognosis. Sensitivity and Specificity

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  • (PMID = 20726306.001).
  • [ISSN] 1221-9118
  • [Journal-full-title] Chirurgia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Chirurgia (Bucur)
  • [Language] rum
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Romania
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61. Manzanares MC, Villarejo P, López A, Padilla D, Cubo T, d e la Plaza R, Jara A, Martínez F, Menchén B, Molina JM, Pardo R, Martín J, García M: [Immunohystochemical and prognosis features of adenocarcinoid tumor of the ampulla of Vater]. Rev Esp Enferm Dig; 2006 Dec;98(12):966-8
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  • [Title] [Immunohystochemical and prognosis features of adenocarcinoid tumor of the ampulla of Vater].
  • [Transliterated title] Aspectos inmunohistoquímicos y pronósticos del tumor adenocarcinoide de la ampolla de Vater.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoid Tumor / pathology. Common Bile Duct Neoplasms / pathology

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  • (PMID = 17274703.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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62. Iacono C, Verlato G, Zamboni G, Scarpa A, Montresor E, Capelli P, Bortolasi L, Serio G: Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors. J Gastrointest Surg; 2007 May;11(5):578-88
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  • [Title] Adenocarcinoma of the ampulla of Vater: T-stage, chromosome 17p allelic loss, and extended pancreaticoduodenectomy are relevant prognostic factors.
  • OBJECTIVE: To evaluate the prognostic significance of different clinico-pathological and molecular factors, and to compare survival after standard and extended pancreaticoduodenectomy (PD) in ampulla of Vater adenocarcinoma (AVAC).
  • RESULTS: The overall 5- and 10-year tumor-related survival rates were 46% and 33%, respectively.
  • CONCLUSION: MSI and chromosome 17p status allow to better define prognosis within ampullary cancers at the same stage.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater / pathology. Chromosomes, Human, Pair 17 / genetics. Common Bile Duct Neoplasms / pathology. Loss of Heterozygosity / genetics. Pancreaticoduodenectomy
  • [MeSH-minor] Aged. Chromosomes, Human, Pair 18 / genetics. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lymphatic Metastasis / pathology. Male. Microsatellite Instability. Middle Aged. Neoadjuvant Therapy. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 17468917.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Singhal D, Kumar M, Sud R, Chaudhary A: Image of the month. Gastrointestinal Stromal Tumor of the Ampulla of Vater. Arch Surg; 2007 Sep;142(9):899-900
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  • [Title] Image of the month. Gastrointestinal Stromal Tumor of the Ampulla of Vater.
  • [MeSH-major] Ampulla of Vater / ultrasonography. Endosonography. Gastrointestinal Stromal Tumors / ultrasonography
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 17875846.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Green D, Rowsell C, Cohen L: Metastatic bladder carcinoma to ampulla of Vater. Gastrointest Endosc; 2008 Jul;68(1):199-200
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  • [Title] Metastatic bladder carcinoma to ampulla of Vater.
  • [MeSH-major] Ampulla of Vater / pathology. Carcinoma / secondary. Common Bile Duct Neoplasms / secondary. Neoplasm Recurrence, Local / pathology. Stents

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  • (PMID = 18291394.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Ridwelski K, Meyer F, Schmidt U, Lippert H: [Results of surgical treatment in ampullary and pancreatic carcinoma and its prognostic parameters after R0-resection]. Zentralbl Chir; 2005 Aug;130(4):353-61
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  • [Title] [Results of surgical treatment in ampullary and pancreatic carcinoma and its prognostic parameters after R0-resection].
  • [Transliterated title] Ergebnisse der chirurgischen Therapie beim Papillen- und Pankreaskarzinom sowie Prognoseparameter nach R0-Resektion. Chirurgie und Prognose des Pankreaskarzinoms.
  • INTRODUCTION: Resection is currently the only established reasonable therapeutic option with curative potential in pancreatic and ampullary carcinoma.
  • METHODS: Two-hundred-twenty patients with pancreatic and ampullary carcinoma (mean age, 61.4 years; 104 females/116 males) underwent surgery.
  • Histologic investigation revealed 19 carcinomas of the papilla of Vater and 201 ductal pancreatic carcinomas.
  • RESULTS: Hundred-ten patients underwent tumor resection with primary curative intention (50 %): 96 resections of the pancreatic head, 2 total pancreatectomies and 12 left resections of the pancreas.
  • Five-year survival-rate of carcinoma of the papilla of Vater and pancreatic carcinoma was 73.3 % and 16.2 %, respectively (median survival time was 66.0 and 14.0 months, respectively).
  • In addition, prognosis after successful R0-resection is determined significantly by tumor site, stage of the tumor (according to UICC), T- and N-category.
  • CONCLUSION: Resection of pancreatic and ampullary carcinoma according to oncological criteria with tumor-free margins can be considered a treatment option with curative intention and potential.
  • Interventions with primary palliative intention or resections with microscopically or macroscopically detectable tumor residual in situ lead to no significant or only marginal prolongation of survival time.
  • They are of value only for treatment of tumor-associated complications and problems.
  • [MeSH-major] Ampulla of Vater. Carcinoma, Pancreatic Ductal / surgery. Common Bile Duct Neoplasms / surgery. Pancreatectomy. Pancreatic Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anastomosis, Surgical. Female. Gastroenterostomy. Humans. Male. Middle Aged. Neoplasm Staging. Pancreas / pathology. Postoperative Complications. Prognosis. Survival Analysis. Time Factors

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  • (PMID = 16103961.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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66. Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J: Diagnosis of ampullary cancer. Dig Surg; 2010;27(2):115-8
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  • [Title] Diagnosis of ampullary cancer.
  • Endoscopic papillectomy has been reported to be the treatment of choice in patients with ampullary adenoma.
  • For ampullary cancer, pancreaticoduodenectomy is the standard treatment.
  • Since neither lymphatic permeation, vascular invasion, nor lymph node metastasis is observed in patients with ampullary cancer limited to the mucosa, endoscopic resection of such tumors can be justified if no ductal infiltration into the bile or pancreatic duct is documented.
  • [MeSH-major] Ampulla of Vater / pathology. Common Bile Duct Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Cholangiopancreatography, Endoscopic Retrograde. Cholangiopancreatography, Magnetic Resonance. Diagnosis, Differential. Humans. Neoplasm Invasiveness. Neoplasm Staging. Pancreaticoduodenectomy / methods. Patient Selection. Tomography, X-Ray Computed

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  • [Copyright] (c) 2010 S. Karger AG, Basel.
  • (PMID = 20551654.001).
  • [ISSN] 1421-9883
  • [Journal-full-title] Digestive surgery
  • [ISO-abbreviation] Dig Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 17
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67. Guercioni G, Marmorale C, Siquini W, Fianchini M, Fianchini A, Landi E: Incidental small ampullary somatostatinoma treated with ampullectomy 2 years after diagnosis. Dig Dis Sci; 2006 Oct;51(10):1767-72
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  • [Title] Incidental small ampullary somatostatinoma treated with ampullectomy 2 years after diagnosis.
  • Somatostatinomas are rare tumors; ampullary somatostatinomas are very rare.
  • We report a case of a small pure somatostatin-producing neuroendocrine tumor of ampulla of Vater in a 54-year-old woman with neither neurofibromatosis nor somatostatinoma syndrome, "incidentally" discovered during an abdominal computed tomography.
  • The size of the tumor (1.5 cm) and the other radiologic findings had not changed since the abdominal CT scan 2 years before.
  • ERCP-obtained biopsies revealed a neuroendocrine tumor with psammoma bodies; immunohistochemical profile was positive for chromogranin and somatostatin.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Somatostatinoma / surgery

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  • (PMID = 16967313.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. O'Connor JK, Sause WT, Hazard LJ, Belnap LP, Noyes RD: Survival after attempted surgical resection and intraoperative radiation therapy for pancreatic and periampullary adenocarcinoma. Int J Radiat Oncol Biol Phys; 2005 Nov 15;63(4):1060-6
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  • Forty-four patients with tumors located in the pancreas and 9 patients with periampullary tumors underwent potentially curative surgical resection and IORT.
  • [MeSH-major] Adenocarcinoma / mortality. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Pancreatic Neoplasms / mortality
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Combined Modality Therapy. Female. Fluorouracil / administration & dosage. Humans. Intraoperative Period. Male. Middle Aged. Neoplasm, Residual. Pancreaticoduodenectomy. Statistics, Nonparametric. Survival Analysis

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  • (PMID = 15978737.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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69. He KJ, Jiao XY, Yang XW, Hu YZ: [Risk factors of postoperative complications of pancreatoduodenectomy]. Ai Zheng; 2008 Jan;27(1):75-7
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  • METHODS: Clinical data of 94 patients with pancreatic carcinoma or periampullary carcinoma, underwent pancreatoduodenectomy at the second affiliated hospital of Guangzhou Medical Collage and Gansu Provincial Tumor Hospital from Jan.
  • RESULTS: Univariate analysis showed that major risk factors of postoperative mortality and morbidity of the patients were total serum bilirubin level, serum album level, duration of jaundice, decompression of jaundice, operating time, intra-operative bleeding, and depth of tumor invasion (P<0.05).
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / adverse effects. Postoperative Hemorrhage / etiology
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Female. Gastrointestinal Hemorrhage / etiology. Humans. Male. Middle Aged. Neoplasm Invasiveness. Pancreatic Fistula / etiology. Proportional Hazards Models. Retrospective Studies. Risk Factors. Serum Albumin / metabolism. Survival Rate

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  • (PMID = 18184469.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Serum Albumin
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70. Chang SC, Rashid A, Gao YT, Andreotti G, Shen MC, Wang BS, Han TQ, Zhang BH, Sakoda LC, Leitzmann MF, Chen BE, Rosenberg PS, Chen J, Chanock SJ, Hsing AW: Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China. Carcinogenesis; 2008 May;29(5):944-8
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  • Biliary tract cancer, encompassing tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, is a rare but highly fatal malignancy.
  • We included 237 gallbladder, 127 extrahepatic bile duct and 47 ampulla of Vater cancer cases, 895 stone cases and 786 population controls.

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  • (PMID = 18375961.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Insulin; 0 / PPAR gamma; 0 / Receptors, Retinoic Acid; 0 / retinoic acid receptor alpha; 0 / retinoic acid receptor beta
  • [Other-IDs] NLM/ PMC2443392
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71. Nagano Y, Sekido H, Matsuoi K, Ohtsuki K, Gorai K, Kunisaki C, Ike H, Imada T, Shimada H: Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy. Hepatogastroenterology; 2005 May-Jun;52(63):933-5
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  • [Title] Successful pancreatoduodenectomy for carcinoma of the ampulla of vater after esophagectomy with remnant gastrectomy.
  • Duodenoscopy was performed and showed the protruded lesion of the ampulla of Vater, biopsied specimens from this tumor revealed adenocarcinomas.
  • The problem in this case was that the rt middle colic artery (MCA), and the middle colic vein (MCV) tend to be injured because these vessels are situated near the caudal region of the pancreas.
  • Double cancer of the ampulla of Vater and the esophagus are extremely rare, with only 4 cases reported.
  • [MeSH-major] Adenocarcinoma / surgery. Ampulla of Vater / surgery. Common Bile Duct Neoplasms / surgery. Esophageal Neoplasms / surgery. Esophagectomy. Gastrectomy. Gastric Stump / surgery. Neoplasms, Multiple Primary / surgery. Pancreaticoduodenectomy. Postoperative Complications / surgery
  • [MeSH-minor] Adenoma / surgery. Humans. Lymph Node Excision. Middle Aged. Neoplasm Invasiveness. Reoperation. Stomach Neoplasms / surgery

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  • (PMID = 15966235.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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72. Hirono S, Tani M, Terasawa H, Kawai M, Ina S, Uchiyama K, Nakamura Y, Kakudo K, Yamaue H: A collision tumor composed of cancers of the bile duct and ampulla of Vater--immunohistochemical analysis of a rare entity of double cancer. Hepatogastroenterology; 2008 May-Jun;55(84):861-4
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  • [Title] A collision tumor composed of cancers of the bile duct and ampulla of Vater--immunohistochemical analysis of a rare entity of double cancer.
  • Collision cancer of the bile duct and the papilla of Vater is an extremely rare entity.
  • Computed tomography showed isodensity masses in the middle bile duct and the papilla of Vater.
  • Gastroduodenal endoscopy showed a tumor with ulceration at the papilla of Vater.
  • The patient was diagnosed with cancers of the middle bile duct and the papilla of Vater, and a pylorus-preserving pancreatoduodenectomy was performed.
  • On pathological examination, the tumor in the middle bile duct showed a well differentiated carcinoma that had spread to the proximal bile duct, whereas the tumor in the papilla of Vater showed a papillo-tubular carcinoma with a marked production of mucin, suggesting an intestinal type of ampullary cancer.
  • As a result, it was concluded that this was a case of collision cancer of the middle bile duct and the papilla of Vater.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Papillary / pathology. Ampulla of Vater / pathology. Biomarkers, Tumor / analysis. Common Bile Duct Neoplasms / pathology. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Aged. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct / pathology. Diagnosis, Differential. Duodenum / pathology. Humans. Male. Neoplasm Invasiveness. Neoplasm Staging. Pancreaticoduodenectomy. Tomography, X-Ray Computed

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  • (PMID = 18705284.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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73. Sawaki A, Mizuno N, Hoki N, Ishikawa H, Takagi T, Yamao K: [Effect of S-1 in a patient with post-operative recurrence of carcinoma of the ampulla of Vater]. Gan To Kagaku Ryoho; 2007 Dec;34(13):2301-3
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  • [Title] [Effect of S-1 in a patient with post-operative recurrence of carcinoma of the ampulla of Vater].
  • We report a case of recurrent carcinoma of the ampulla of Vater with multiple lung and abdominal lymph node metastases that well responded to S-1, an oral fluoropyrimidine.
  • A 56-years-old woman underwent a pylorus-preserving pancreaticoduodenectomy for carcinoma of the ampulla of Vater in October 2003.
  • Anti-tumor efficacy was confirmed to be partial response by Response Evaluation Criteria in Solid Tumors (RECIST).
  • S-1 might be an effective and safe agent for carcinoma of the ampulla of Vater.
  • [MeSH-major] Ampulla of Vater. Antimetabolites, Antineoplastic / therapeutic use. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / surgery. Oxonic Acid / therapeutic use. Tegafur / therapeutic use
  • [MeSH-minor] Drug Combinations. Female. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Middle Aged. Neoplasm Recurrence, Local. Pancreaticoduodenectomy

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  • (PMID = 18079635.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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74. Malik S, Kaushik N, Khalid A, Bauer K, Brody D, Slivka A, McGrath K: EUS yield in evaluating biliary dilatation in patients with normal serum liver enzymes. Dig Dis Sci; 2007 Feb;52(2):508-12
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  • Of 15 patients with elevated serum liver enzymes, there were 3 cases of choledocholithiasis, 4 periampullary diverticula, and 1 ampullary tumor.

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  • (PMID = 17211694.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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75. Qiao QL, Zhao YG, Ye ML, Yang YM, Zhao JX, Huang YT, Wan YL: Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection. World J Surg; 2007 Jan;31(1):137-43; discussion 144-6
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  • [Title] Carcinoma of the ampulla of Vater: factors influencing long-term survival of 127 patients with resection.
  • INTRODUCTION: The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms.
  • Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected.
  • The aim of the present study was to determine the clinicopathologic factors that influence long-term survival in patients with resected ampullary carcinoma.
  • METHODS: Clinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002.
  • Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (n = 124) or local resection (n = 3).
  • Factors that significantly influenced survival were lymph node status (P < 0.001), depth of tumor infiltration (P = 0.029), and TNM stage (P < 0.001) on univariate analysis.
  • CONCLUSIONS: Carcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer.
  • Pancreaticoduodenectomy is the treatment of choice for this tumor.
  • Long-term survival was independently influenced by the depth of tumor infiltration and lymph node metastasis.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Ampulla of Vater. Common Bile Duct Neoplasms / mortality. Common Bile Duct Neoplasms / surgery. Pancreaticoduodenectomy
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Hospital Mortality. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Proportional Hazards Models. Retrospective Studies. Survival Analysis

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  • (PMID = 17171495.001).
  • [ISSN] 0364-2313
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Berberat PO, Künzli BM, Gulbinas A, Ramanauskas T, Kleeff J, Müller MW, Wagner M, Friess H, Büchler MW: An audit of outcomes of a series of periampullary carcinomas. Eur J Surg Oncol; 2009 Feb;35(2):187-91
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  • BACKGROUND: Non-pancreatic periampullary carcinoma such as ampullary carcinoma (AmpCA), distal cholangiocellular carcinoma (CholCA) and duodenal carcinoma (DuoCA) have a better prognosis than pancreatic head adenocarcinoma (PanCA).
  • In AmpCA low tumor stages are also an independent predictor of long-term survival (p<0.01).
  • For T1/T2 AmpCA the 5-year survival rate was 61%, whereas none of the patients with a T3/T4 tumor survived 5 years.
  • CONCLUSION: Only T1/T2 ampullary carcinomas have a good prognosis, whereas T3/T4 ampullary tumors show aggressiveness similar to that of pancreatic head adenocarcinomas.
  • [MeSH-major] Ampulla of Vater. Biliary Tract Surgical Procedures / methods. Carcinoma / surgery. Clinical Audit / methods. Common Bile Duct Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Prospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 18343082.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] England
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77. Jayaprakash N, O'Kelly F, Lim KT, Reynolds JV: Management of synchronous adenocarcinoma of the esophago-gastric junction and ampulla of Vater: case report of a surgically challenging condition. Patient Saf Surg; 2009;3(1):23
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  • [Title] Management of synchronous adenocarcinoma of the esophago-gastric junction and ampulla of Vater: case report of a surgically challenging condition.
  • We report herein a case of a synchronous presentation of an adenocarcinoma of esophagago-gastric junction type II and an ampullary tumor that was treated by combined Whipple's pancreaticoduodenectomy, total gastrectomy and esophagectomy.

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  • (PMID = 19785744.001).
  • [ISSN] 1754-9493
  • [Journal-full-title] Patient safety in surgery
  • [ISO-abbreviation] Patient Saf Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2760510
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78. Aloysius MM, Hewavisenthi SJ, Bates TE, Rowlands BJ, Lobo DN, Zaitoun AM: Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays. World J Surg; 2010 Sep;34(9):2115-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Predictive value of tumor proliferative indices in periampullary cancers: Ki-67, mitotic activity index (MI) and volume corrected mitotic index (M/V) using tissue microarrays.
  • Expression of Ki-67 was assessed as the percentage of cancer cell nuclei expressing MIB1, MI as the mean percentage of Ki-67 from 10 random high-power fields, and M/V was calculated after standardizing MI for connective tissue volume and microscope parameters in the tumor using established protocols.
  • There was no statistically significant difference in survival, based on M/V score, for tumors of the intestinal subtype (ampullary and duodenal adenocarcinoma).
  • CONCLUSIONS: In periampullary cancers, Ki-67 and MI are proliferative indices predictive of tumor behavior.
  • [MeSH-major] Ampulla of Vater. Bile Duct Neoplasms / metabolism. Bile Ducts, Intrahepatic. Carcinoma, Pancreatic Ductal / metabolism. Cholangiocarcinoma / metabolism. Common Bile Duct Neoplasms / metabolism. Duodenal Neoplasms / metabolism. Ki-67 Antigen / analysis. Mitotic Index. Pancreatic Neoplasms / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Lymphatic Metastasis. Microarray Analysis. Neoplasm Invasiveness

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  • (PMID = 20556608.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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79. Kim ST, Lee J, Lee KT, Lee JK, Lee KH, Choi SH, Heo JS, Choi DW, Park SH, Park JO, Lim HY, Park YS, Kang WK: The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater. Med Oncol; 2010 Dec;27(4):1149-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The efficacy of frontline platinum-based combination chemotherapy in advanced adenocarcinoma of the ampulla of Vater.
  • Adenocarcinoma arising from the ampulla of Vater is a rare neoplasm that accounts for only 0.2% of all gastrointestinal tract malignancies and has limited data regarding its frontline therapy.
  • We investigated the treatment outcomes in patients with advanced adenocarcinoma of the ampulla of Vater receiving frontline cisplatin-based combination chemotherapy.
  • We analyzed 29 patients with advanced adenocarcinoma of the ampulla of Vater who had been treated by frontline cisplatin-based combination chemotherapy between June 2003 and April 2008.
  • The cisplatin-based combination chemotherapy showed moderate activity and a favorable toxicity profile as a frontline treatment for patients with advanced adenocarcinoma of the ampulla of Vater.
  • [MeSH-major] Adenocarcinoma / drug therapy. Ampulla of Vater / drug effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Common Bile Duct Neoplasms / drug therapy

  • Hazardous Substances Data Bank. CAPECITABINE .
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  • (PMID = 19898973.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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80. Baumhoer D, Riener MO, Zlobec I, Tornillo L, Vogetseder A, Kristiansen G, Dietmaier W, Hartmann A, Wuensch PH, Sessa F, Ruemmele P, Terracciano LM: Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater. Mod Pathol; 2009 Feb;22(2):306-13
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  • [Title] Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater.
  • We therefore investigated their expression in 177 carcinoma, 114 adenoma and 152 normal mucosa specimens of the ampulla of Vater.
  • CD24 and S100A4, furthermore, can assist in the differential diagnosis of dysplasia vs invasive carcinoma.
  • [MeSH-major] Adenoma / chemistry. Ampulla of Vater / chemistry. Antigens, CD24 / analysis. Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma / chemistry. Common Bile Duct Neoplasms / chemistry. S100 Proteins / analysis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Europe. Female. Humans. Male. Middle Aged. Mucous Membrane / chemistry. Neoplasm Invasiveness. Young Adult

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  • (PMID = 19043399.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD24; 0 / Biomarkers, Tumor; 0 / CD24 protein, human; 0 / CDH3 protein, human; 0 / Cadherins; 0 / S100 Proteins; 142662-27-9 / S100A4 protein, human
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81. Wu TC, Shao YF, Shan Y, Wu JX, Zhao DB, Xu LB, Zhao P: [Prognostic implication of common bile duct infiltration in adenocarcinoma of the ampulla of Vater after pancreaticoduodenectomy]. Zhonghua Zhong Liu Za Zhi; 2008 Oct;30(10):775-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prognostic implication of common bile duct infiltration in adenocarcinoma of the ampulla of Vater after pancreaticoduodenectomy].
  • OBJECTIVE: To investigate the prognostic implication of common bile duct infiltration in the adenocarcinoma of the ampulla of Vater after panreaticoduodenectomy.
  • METHODS: A retrospective study was conducted on clinical manifestation, pathological behavior and survival data in 102 patients with Vater's ampulla adenocarcinoma, who underwent pancreaticoduodenectomy from Jan 1980 to Dec 2003.
  • CONCLUSION: If the adenocarcinoma of the Vater's ampulla infiltrated the common bile duct, the invasion to the pancreatic medulla is likely developed, and usually with a poor non-recurrence and overall survival.
  • [MeSH-major] Adenocarcinoma. Ampulla of Vater. Common Bile Duct / pathology. Common Bile Duct Neoplasms. Pancreaticoduodenectomy
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Liver Neoplasms / secondary. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Retrospective Studies. Survival Rate

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  • (PMID = 19173811.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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82. Karachaliou N, Polyzos A, Kentepozidis N, Kakolyris S, Ziras N, Vardakis N, Kalykaki A, Milaki G, Georgoulias V, Androulakis N: A multicenter phase II trial with irinotecan plus oxaliplatin as first-line treatment for inoperable/metastatic cancer of the biliary tract. Oncology; 2010;78(5-6):356-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adult. Aged. Ampulla of Vater / pathology. Cholangiocarcinoma / drug therapy. Cholangiocarcinoma / pathology. Common Bile Duct Neoplasms / drug therapy. Common Bile Duct Neoplasms / pathology. Female. Gallbladder Neoplasms / drug therapy. Gallbladder Neoplasms / pathology. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Staging

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  • [Copyright] Copyright ©2010 S. Karger AG, Basel.
  • (PMID = 20798557.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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83. Sung JY, Kim GY, Lim SJ, Park YK, Kim YW: Expression of the GLUT1 glucose transporter and p53 in carcinomas of the pancreatobiliary tract. Pathol Res Pract; 2010 Jan 15;206(1):24-9
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  • Positive expression of GLUT1 was identified in 38 out of 67 (57.7%) ampulla of Vater (AV) carcinomas, in 27 out of 52 (51.8%) pancreatic (PA) carcinomas, in 38 out of 121 (31.4%) extrahepatic bile duct (EBD) carcinomas, and in 53 out of 115 (46.5%) gallbladder (GB) carcinomas.
  • [MeSH-major] Ampulla of Vater / metabolism. Bile Duct Neoplasms / metabolism. Bile Ducts, Extrahepatic / metabolism. Carcinoma / metabolism. Gallbladder Neoplasms / metabolism. Glucose Transporter Type 1 / metabolism. Pancreatic Neoplasms / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Aged. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Prognosis. Proportional Hazards Models

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  • [Copyright] Copyright 2009 Elsevier GmbH. All rights reserved.
  • (PMID = 19819644.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glucose Transporter Type 1; 0 / SLC2A1 protein, human; 0 / Tumor Suppressor Protein p53
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84. van der Gaag NA, ten Kate FJ, Lagarde SM, Busch OR, van Gulik TM, Gouma DJ: Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater. Br J Surg; 2008 Jun;95(6):735-43
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  • [Title] Prognostic significance of extracapsular lymph node involvement in patients with adenocarcinoma of the ampulla of Vater.
  • BACKGROUND: Lymphatic dissemination is an important predictor of survival in patients with adenocarcinoma of the ampulla of Vater.
  • METHODS: In a consecutive series of 160 patients with adenocarcinoma of the ampulla of Vater, 75 (46.9 per cent) had positive lymph nodes (N1).
  • The relation of extracapsular LNI with tumour stage and number of positive nodes was evaluated and its prognostic significance analysed.
  • Extracapsular LNI and tumour differentiation were independent prognostic factors for survival.
  • [MeSH-major] Adenocarcinoma / secondary. Ampulla of Vater / pathology. Common Bile Duct Neoplasms / pathology
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Hospital Mortality. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Prognosis. Survival Analysis

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  • [Copyright] 2008 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
  • [CommentIn] Br J Surg. 2008 Sep;95(9):1188; author reply 1188-9 [18690628.001]
  • (PMID = 18300268.001).
  • [ISSN] 1365-2168
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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85. Clemente G, Sarno G, Giordano M, De Rose AM, Nuzzo G: Intramural duodenal diverticulum mimicking a periampullary neoplasm. Am J Surg; 2008 Oct;196(4):e31-2
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  • [Title] Intramural duodenal diverticulum mimicking a periampullary neoplasm.
  • Contrast-enhanced computerized tomography revealed a small mass in the duodenal wall mimicking a periampullary neoplasm and, at endoscopic examination, a periampullary submucosal tumor was suspected.
  • The diagnosis of intramural duodenal diverticulum (IDD) was made by an x-ray barium meal that showed a finger-like sac filled with barium, the so-called "windsock sign."
  • [MeSH-minor] Adult. Ampulla of Vater / radiography. Barium Sulfate. Contrast Media. Diagnosis, Differential. Duodenal Neoplasms / radiography. Endoscopy, Gastrointestinal. Female. Humans. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 18614138.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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86. Rohan VS, Narendra H, Patel JJ, Tankshali RA: Carcinoid of ampulla of Vater. Indian J Cancer; 2007 Apr-Jun;44(2):90-2
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  • [Title] Carcinoid of ampulla of Vater.
  • Carcinoid tumors of ampulla are rare clinical entities.
  • Since the metastatic potential and the tumor size have no correlation, unlike in duodenal carcinoids, pancreatoduodenectomy is considered the treatment of choice.
  • Here we present a case of carcinoid of ampulla presenting to our department.
  • [MeSH-major] Ampulla of Vater. Carcinoid Tumor. Common Bile Duct Neoplasms
  • [MeSH-minor] Abdominal Pain. Adult. Biopsy. Female. Humans. Laparotomy. Neoplasm Metastasis

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  • [CommentIn] Indian J Cancer. 2008 Jan-Mar;45(1):37 [18453741.001]
  • (PMID = 17938486.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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87. Valls C: [Obstructive Jaundice: diagnostic and therapeutic management]. J Radiol; 2006 Apr;87(4 Pt 2):460-78
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  • [Transliterated title] L'ictère nu: rôle du radiologue dans la prise en charge diagnostique et thérapeutique.
  • The purpose of this article is to provide an update on imaging techniques for diagnosis and staging of clinical conditions leading to obstructive jaundice.
  • Imaging and treatment strategies will be discussed in order to provide an optimal diagnosis and staging with the least invasive techniques in order to minimize complications in these patients.
  • [MeSH-major] Bile Duct Neoplasms / diagnosis. Jaundice, Obstructive / diagnosis. Pancreatic Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / radiography. Adenocarcinoma / surgery. Aged. Ampulla of Vater. Bile Ducts, Intrahepatic. Cholangiocarcinoma / diagnosis. Cholangiocarcinoma / radiography. Cholangiopancreatography, Magnetic Resonance. Common Bile Duct Neoplasms / diagnosis. Common Bile Duct Neoplasms / radiography. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Pancreas / abnormalities. Pancreatic Pseudocyst / diagnosis. Pancreatic Pseudocyst / radiography. Pancreatitis, Chronic / diagnosis. Pancreatitis, Chronic / radiography. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 16691176.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 44
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88. Artifon EL, Couto D Jr, Sakai P, da Silveira EB: Prospective evaluation of EUS versus CT scan for staging of ampullary cancer. Gastrointest Endosc; 2009 Aug;70(2):290-6
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  • [Title] Prospective evaluation of EUS versus CT scan for staging of ampullary cancer.
  • However, ampullary cancer carries a better prognosis and is often diagnosed when curative treatment is still possible.
  • (1) To determine the test performance characteristics of EUS and CT in loco-regional staging of ampullary neoplasms, and (2) to determine the impact of CT scan results on the test performance characteristics of EUS.
  • Tumor classifications were as follows: 2 patients (7.4%), T1 tumors; 13 patients (48.1%), T2 tumors; and 12 patients (44.4%), T3 tumors, as per surgical pathology.
  • The difference in proportion of correct tumor (74.1% vs 51.8%; P = .15, 95% CI, -0.06-0.50) and lymph node (81.4% vs 55.5%; P = .07, 95% CI, -0.01-0.53) staging by EUS and CT, respectively, was not statistically significantly different.
  • However, the strength of tumor (kappa 0.51 vs 0.11) and nodal (kappa 0.59 vs 0.05) agreement with pathology was statistically significantly higher for EUS than for CT (P < .05).
  • EUS was more sensitive and specific than CT for tumor and nodal staging, and the association of CT to EUS data did not improve the final test accuracy.
  • Therefore, the evaluation for metastatic disease should not be compromised by CT protocols that aim to perform tumor and nodal staging.
  • Further studies to determine the role of specialized CT protocols in patients with ampullary malignancies are needed.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Common Bile Duct Neoplasms / pathology. Endosonography. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies

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  • (PMID = 19523619.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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89. Ferrando Marco J, Pallas Regueira A, Moro Valdezate D, Fernández Martínez C: [Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma]. Rev Esp Enferm Dig; 2007 Apr;99(4):235-8
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  • [Title] [Collision tumor of the ampulla of Vater: carcinoid and adenocarcinoma].
  • [Transliterated title] Tumor de colisión periampular.
  • We report the case of a periampullary collision tumor, in which a duodenal-wall carcinoid and an adenocarcinoma of the head of the pancreas coexisted.
  • Solid cords and nests of neuroendocrine cells in the duodenal wall formed the carcinoid tumor, whereas the other neoplasm was made up of a well-differentiated adenocarcinoma of the pancreas.
  • [MeSH-major] Adenocarcinoma / pathology. Ampulla of Vater. Carcinoid Tumor / pathology. Common Bile Duct Neoplasms / pathology. Duodenal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pancreatic Neoplasms / pathology

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  • (PMID = 17590108.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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90. Aimoto T, Uchida E, Nakamura Y, Katsuno A, Chou K, Tajiri T, Naito Z: Malignant afferent loop obstruction following pancreaticoduodenectomy: report of two cases. J Nippon Med Sch; 2006 Aug;73(4):226-30
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  • Laparotomy confirmed the diagnosis of local recurrent tumor causing occlusion of the afferent limb, and Roux-en-Y bypass was performed. Case 2.
  • [MeSH-minor] Aged. Ampulla of Vater. Carcinoma / complications. Common Bile Duct Neoplasms / complications. Female. Humans. Male. Neoplasm Recurrence, Local. Pancreatic Neoplasms / complications. Postoperative Complications

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  • (PMID = 16936449.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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91. Lee SY, Jang KT, Lee KT, Lee JK, Choi SH, Heo JS, Paik SW, Rhee JC: Can endoscopic resection be applied for early stage ampulla of Vater cancer? Gastrointest Endosc; 2006 May;63(6):783-8
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  • [Title] Can endoscopic resection be applied for early stage ampulla of Vater cancer?
  • BACKGROUND: Although endoscopic resection can provide a wide tumor resection with a negative resection margin, it is not yet recommended as a curative therapy for ampulla of Vater cancer.
  • METHODS: To investigate the microinvasion rate and the diagnostic accuracy of endoscopic biopsy to properly judge the safety of endoscopic resection for ampulla of Vater cancer.
  • PATIENTS: One hundred fifty-nine patients who were finally diagnosed with ampulla of Vater cancer after curative surgical resection.
  • For the 36 early stage (Tis or T1) cancers, we surveyed the presence of microlymphovascular invasion, gross appearance (intra-ampullary type, periampullary type, or mixed type), and pathologic subtype (intestinal type or pancreaticobiliary type).
  • MAIN OUTCOME MEASUREMENTS: Presence of microinvasion in early staged ampulla of Vater cancer.
  • CONCLUSIONS: Although endoscopic resection improves the low predictability of endoscopic biopsy, surgical resection should be performed for the T1 stage ampulla of Vater cancer because of the high lymphovascular invasion rate.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / surgery. Sphincter of Oddi. Sphincterotomy, Endoscopic
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Analysis

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  • [CommentIn] Gastrointest Endosc. 2006 May;63(6):789-91 [16650539.001]
  • (PMID = 16650538.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. El Idrissi-Lamghari A, Rioux-Leclercq N, Pagenault M, Bretagne JF: Voluminous juxtapapillary gangliocytic paraganglioma. Gastrointest Endosc; 2005 Sep;62(3):445-6; discussion 446
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Ampulla of Vater / pathology. Duodenal Neoplasms / pathology. Duodenoscopy / methods. Neoplasm Invasiveness / pathology. Paraganglioma / pathology

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  • (PMID = 16111971.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J, Takasawa O, Obana T: Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study. Gastrointest Endosc; 2007 Oct;66(4):740-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative evaluation of ampullary neoplasm with EUS and transpapillary intraductal US: a prospective and histopathologically controlled study.
  • BACKGROUND: Endoscopic papillectomy is performed in selected patients with ampullary neoplasm, and, thus, accurate preoperative tumor staging is indispensable for its application.
  • PATIENTS AND INTERVENTIONS: EUS and transpapillary intraductal US (IDUS) were performed in 40 patients with ampullary neoplasm before surgery (n = 30) or endoscopic papillectomy (n = 10).
  • Ductal infiltration by a tumor into the bile duct (BD) or the pancreatic duct (PD) was also evaluated.
  • Tumor depiction by EUS and IDUS was achieved in 95% and 100% of the patients, respectively.
  • CONCLUSION: Although IDUS had a tendency of overestimation in tumor staging for ampullary neoplasm, it can provide useful information for making therapeutic decisions, especially in cases appropriate for endoscopic papillectomy.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms. Duodenoscopy / methods. Endosonography / methods. Preoperative Care / methods. Sphincterotomy, Endoscopic / methods
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Adenoma / pathology. Adenoma / surgery. Adenoma / ultrasonography. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies. Reproducibility of Results

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  • (PMID = 17905017.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
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94. Doucas H, Sutton CD, Zimmerman A, Dennison AR, Berry DP: Assessment of pancreatic malignancy with laparoscopy and intraoperative ultrasound. Surg Endosc; 2007 Jul;21(7):1147-52
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  • The entry criteria specified radiologic (computed tomography) diagnosis of pancreatic carcinoma and no evidence of metastases.
  • At laparoscopy, three patients had a normal examination, with no evidence of a pancreatic mass, and an additional seven patients had other pathology including one lymphoma, one ampullary tumor, two cases of chronic pancreatitis, and three sarcomas.
  • CONCLUSION: Of the patients thought to have a resectable tumor on the basis of good quality preoperative imaging, 44% had their management approach altered after laparoscopy and avoided an open procedure.
  • [MeSH-major] Endosonography / methods. Laparoscopy / methods. Neoplasm Staging / methods. Pancreatic Neoplasms / diagnostic imaging. Pancreatic Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness / diagnostic imaging. Neoplasm Invasiveness / pathology. Pancreatectomy / methods. Preoperative Care / methods. Retrospective Studies. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 17177081.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
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95. de Castro SM, Houwert JT, Lagarde SM, Reitsma JB, Busch OR, van Gulik TM, Obertop H, Gouma DJ: Evaluation of POSSUM for patients undergoing pancreatoduodenectomy. World J Surg; 2009 Jul;33(7):1481-7
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  • In multivariate analysis, one statistically significant factor associated with morbidity and not incorporated in POSSUM (P < 0.05) was identified: ampulla of Vater adenocarcinoma (OR = 1.73, 95% CI: 1.07-2.80).
  • [MeSH-major] Neoplasm Invasiveness / pathology. Pancreatic Neoplasms / mortality. Pancreatic Neoplasms / surgery. Pancreaticoduodenectomy / mortality. Postoperative Complications / mortality
  • [MeSH-minor] Aged. Analysis of Variance. Cohort Studies. Confidence Intervals. Disease-Free Survival. Female. Humans. Linear Models. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Netherlands. Odds Ratio. Postoperative Care / methods. Predictive Value of Tests. Preoperative Care / methods. Probability. Prognosis. Retrospective Studies. Risk Assessment. Severity of Illness Index. Survival Analysis

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  • (PMID = 19384458.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2691933
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96. Prenzel KL, Warnecke-Eberz U, Brabender J, Baldus SE, Bollschweiler E, Gutschow CA, Drebber U, Hoelscher AH, Schneider PM: Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater. World J Gastroenterol; 2006 Jan 21;12(3):437-42
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  • [Title] Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater.
  • AIM: We examined quantitative mRNA expression of growth factor receptors (c-erbB-1, c-erbB-2) and the anti-apoptosis gene survivin known to be regulated in pancreatic adenocarcinomas and compared the expression pattern with that in carcinomas of the papilla of Vater.
  • METHODS: Quantitative real-time reverse transcriptase-PCR (QRT-PCR, Taqman) was performed to analyze mRNA expression levels of c-erbB-1, c-erbB-2 and survivin in normal and corresponding tumor samples of 31 pancreatic adenocarcinomas and 8 cancers of the papilla of Vater.
  • RESULTS: The overall median mRNA expression of survivin was significantly increased in both adenocarcinoma of the pancreas (P<0.01) and papilla of Vater (P<0.008) compared with uninvolved normal control tissue.
  • In pancreatic cancer, expression of c-erbB-1 was significantly decreased compared with the normal pancreatic tissue (P<0.03), whereas in the cancer of the papilla of Vater expression of c-erbB-2 was significantly downregulated (P<0.05) compared with the paired normal samples.
  • Gene expression was not associated with tumor stage, differentiation or prognosis.
  • CONCLUSION: The common anti-apoptosis gene survivin is overexpressed both in the cancer of the papilla of Vater and pancreas.
  • In contrast, the growth factor receptor genes c-erbB-1 and c-erbB-2 are differentially regulated in both tumor entities adding further evidence that pancreatic cancer is biologically different from the cancer of papilla of Vater.
  • [MeSH-major] Adenocarcinoma / metabolism. Ampulla of Vater. Common Bile Duct Neoplasms / metabolism. Pancreatic Neoplasms / metabolism. RNA, Messenger / genetics. Receptor, Epidermal Growth Factor / metabolism. Receptor, ErbB-2 / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Inhibitor of Apoptosis Proteins. Male. Microtubule-Associated Proteins / genetics. Microtubule-Associated Proteins / metabolism. Middle Aged. Neoplasm Proteins / genetics. Neoplasm Proteins / metabolism. Retrospective Studies. Survival Rate

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  • (PMID = 16489645.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ PMC4066064
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97. Yoon YS, Kim SW, Park SJ, Lee HS, Jang JY, Choi MG, Kim WH, Lee KU, Park YH: Clinicopathologic analysis of early ampullary cancers with a focus on the feasibility of ampullectomy. Ann Surg; 2005 Jul;242(1):92-100
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  • [Title] Clinicopathologic analysis of early ampullary cancers with a focus on the feasibility of ampullectomy.
  • OBJECTIVE: The purpose of this study was to evaluate whether ampullectomy can substitute for pancreatoduodenectomy (PD) in early ampullary cancer by clinicopathologic study.
  • SUMMARY BACKGROUND DATA: Although ampullectomy has been attempted in early ampullary cancer (pTis, pT1), the indication and extent of resection have not been established.
  • METHODS: Of 201 patients who had undergone PD for ampullary cancer between 1986 and 2002, 67 patients with a histologic diagnosis of pTis (n = 5) or pT1 (n = 62) cancer were analyzed retrospectively.
  • RESULTS: The 5-year survival rate of the 66 patients with early ampullary cancer (excluding one mortality) was 83.7%.
  • Pathologic review showed that 22 patients (32.8%) had at least one risk factor for failure after ampullectomy: lymph node metastasis (n = 6, 9.0%), perineural invasion (n = 1), or mucosal tumor infiltration along the CBD or P-duct (n = 15, 22.4%).
  • Moreover, these risk factors were not correlated with tumor size, histologic grade, or the gross morphology of the primary tumor, although pTis cancer or pT1 cancer sized 1.0 cm or less was found to be least associated with risk factors.
  • CONCLUSIONS: Ampullectomy for early ampullary cancer should not be considered an alternative operation to PD because of the high possibility of recurrence.
  • PD should be preferably performed for adequate radical resection, even in early ampullary cancer, and ampullectomy should be reserved for those who have pTis or pT1 cancer sized 1.0 cm or less with high operative risk.
  • [MeSH-major] Ampulla of Vater / surgery. Common Bile Duct Neoplasms / pathology. Common Bile Duct Neoplasms / surgery. Lymph Nodes / pathology. Neoplasm Recurrence, Local / mortality

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  • (PMID = 15973106.001).
  • [ISSN] 0003-4932
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1357709
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98. van Roest MH, Gouw AS, Peeters PM, Porte RJ, Slooff MJ, Fidler V, de Jong KP: Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization. Ann Surg; 2008 Jul;248(1):97-103
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  • [Title] Results of pancreaticoduodenectomy in patients with periampullary adenocarcinoma: perineural growth more important prognostic factor than tumor localization.
  • OBJECTIVE: To study the impact of perineural growth as a prognostic factor in periampullary adenocarcinoma (pancreatic head, ampulla of Vater, distal bile duct, and duodenal carcinoma).
  • Several other prognostic factors for periampullary tumors have been identified, eg, lymph node status, free resection margins, tumor size and differentiation, and vascular invasion.
  • RESULTS: Perineural growth was present in 49% of the cases (37 of the 51 patients with pancreatic head carcinoma; 7 of the 30 patients with ampulla of Vater carcinoma; 7 of the 19 with distal bile duct carcinoma; and 8 of the 21 with duodenal carcinoma).
  • Portal or superior mesenteric vein reconstruction and tumor localization were not of statistical significance.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Peripheral Nerves / pathology. Prognosis. Survival Analysis

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  • [CommentIn] Ann Surg. 2009 Mar;249(3):545; author reply 545-6 [19247055.001]
  • (PMID = 18580212.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Hoya Y, Mitsumori N, Yanaga K: The advantages and disadvantages of a Roux-en-Y reconstruction after a distal gastrectomy for gastric cancer. Surg Today; 2009;39(8):647-51
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  • Indications for Roux-en-Y reconstruction after a distal gastrectomy are: (a) When the primary lesion has directly invaded the duodenum or head of the pancreas, the Billroth I operation is likely to result in local recurrence near the anastomosis;.
  • The disadvantages of Roux-en-Y reconstruction include the possible development of stomal ulcer, an increased probability of cholelithiasis, increased difficulty with an endoscopic approach to the ampulla of Vater, and the possibility of Roux stasis syndrome.
  • [MeSH-minor] Duodenogastric Reflux / prevention & control. Gastrectomy. Gastroenterostomy. Humans. Neoplasm Recurrence, Local / prevention & control. Reconstructive Surgical Procedures / methods

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  • (PMID = 19639429.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
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100. Moss AC, Callery MP, Falchuk KR: Gastrointestinal [corrected] stromal tumor of the ampulla of vater mimicking a duodenal ulcer. Clin Gastroenterol Hepatol; 2007 Oct;5(10):A26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastrointestinal [corrected] stromal tumor of the ampulla of vater mimicking a duodenal ulcer.
  • [MeSH-major] Ampulla of Vater. Duodenal Ulcer / diagnosis. Gastrointestinal Stromal Tumors / pathology
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal / methods. Follow-Up Studies. Humans. Male. Middle Aged. Tomography, X-Ray Computed / methods

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  • [ErratumIn] Clin Gastroenterol Hepatol. 2007 Dec;5(12):1494
  • (PMID = 17916534.001).
  • [ISSN] 1542-7714
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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