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Items 1 to 100 of about 519
1. Fulco GM, Nonaka CF, Souza LB, Miguel MC, Pinto LP: Solid ameloblastomas - Retrospective clinical and histopathologic study of 54 cases. Braz J Otorhinolaryngol; 2010 Mar-Apr;76(2):172-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solid ameloblastomas - Retrospective clinical and histopathologic study of 54 cases.
  • Recently, the World Health Organization (WHO) excluded the desmoplastic pattern from the histopathological spectrum of solid ameloblastomas and classified it as a distinct variant, named desmoplastic ameloblastoma.
  • AIM: To perform a retrospective analysis of the clinicopathologic aspects in a case series of solid ameloblastomas.
  • Forty nine cases (90.8%) were classified as solid ameloblastomas, 3 (5.6%) as desmoplastic ameloblastomas, and 2 (3.7%) as hybrid lesions.
  • The most frequent histological patterns in solid ameloblastomas were follicular (77.6%), acanthomatous (69.4%), and plexiform (65.3%).
  • Focal areas of desmoplastic ameloblastomas were identified in 11 solid ameloblastomas (22.4%).
  • CONCLUSION: Despite its characterization as a distinct variant, our results revealed that focal areas of desmoplastic ameloblastomas can be observed with some frequency in conventional ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology

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  • (PMID = 20549076.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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2. Sumi M, Ichikawa Y, Katayama I, Tashiro S, Nakamura T: Diffusion-weighted MR imaging of ameloblastomas and keratocystic odontogenic tumors: differentiation by apparent diffusion coefficients of cystic lesions. AJNR Am J Neuroradiol; 2008 Nov;29(10):1897-901

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diffusion-weighted MR imaging of ameloblastomas and keratocystic odontogenic tumors: differentiation by apparent diffusion coefficients of cystic lesions.
  • BACKGROUND AND PURPOSE: Ameloblastomas and keratocystic odontogenic tumors are major aggressive odontogenic tumors in the maxillomandibular regions, but the differentiation between these 2 tumors is frequently ineffective based on only conventional CT and MR imaging findings.
  • MATERIALS AND METHODS: We prospectively studied 9 patients with ameloblastoma and 7 patients with keratocystic odontogenic tumor using diffusion-weighted MR imaging.
  • The type A nonenhancing lesions were observed in all the ameloblastomas, but they were evident in only 2 keratocystic odontogenic tumors.
  • It is interesting to note that the ADCs of the nonenhancing lesions in the ameloblastomas were significantly higher than those of the nonenhancing lesions in the keratocystic odontogenic tumors (2.48 +/- 0.20 x 10(-3) mm(2)/s vs 1.13 +/- 0.56 x 10(-3) mm(2)/s; P < .001).
  • The ADCs of the solid lesions in the ameloblastomas (1.39 +/- 0.15 x 10(-3) mm(2)/s) were significantly lower than those of the nonenhancing lesions in the ameloblastomas and were similar to those of the nonenhancing lesions in the keratocystic odontogenic tumors.
  • CONCLUSION: ADC determination may be used as an adjunct tool for differentiation between ameloblastomas and keratocystic odontogenic tumors.
  • [MeSH-major] Ameloblastoma / diagnosis. Diffusion Magnetic Resonance Imaging / methods. Image Interpretation, Computer-Assisted / methods. Mandibular Neoplasms / diagnosis. Odontogenic Cysts / diagnosis. Odontogenic Tumors / diagnosis

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  • (PMID = 18719033.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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3. Rizzardi C, Leocata P, Ventura L, Zweyer M, Brollo A, Schneider M, Melato M: Apoptosis-related factors (TRAIL, DR4, DR5, DcR1, DcR2, apoptotic cells) and proliferative activity in ameloblastomas. Anticancer Res; 2009 Apr;29(4):1137-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Apoptosis-related factors (TRAIL, DR4, DR5, DcR1, DcR2, apoptotic cells) and proliferative activity in ameloblastomas.
  • BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas.
  • MATERIALS AND METHODS: The expression of TRAIL and its receptors (TRAIL-R), and the location of apoptotic cells were evaluated in 15 cases of ameloblastoma using immunohistochemistry and an in situ DNA nick-end labeling method.
  • The proliferative activity of ameloblastomas was analyzed by determining the Ki-67 labeling index.
  • RESULTS: TRAIL and TRAIL-R were diffusely expressed in ameloblastomas, without clear correlation with the location of apoptotic cells.
  • Apoptosis and proliferation were opposite in the peripheral and central components of the ameloblastomas.
  • In some ameloblastoma variants, apoptosis and proliferation seemed to modify in the same direction.
  • CONCLUSION: TRAIL and its receptors might be involved in neoplastic transformation of odontogenic epithelium and might suggest some intrinsic regulation of neoplastic cell proliferation and death in ameloblastomas, thus explaining their slow growth and inability to metastasize.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis. Receptors, TNF-Related Apoptosis-Inducing Ligand / metabolism. Receptors, Tumor Necrosis Factor / metabolism. Receptors, Tumor Necrosis Factor, Member 10c / metabolism. TNF-Related Apoptosis-Inducing Ligand / metabolism

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  • (PMID = 19414356.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / Receptors, Tumor Necrosis Factor; 0 / Receptors, Tumor Necrosis Factor, Member 10c; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFRSF10A protein, human; 0 / TNFSF10 protein, human
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4. González-Alva P, Kikuchi K, Miyazaki Y, Okamoto E, Oku Y, Tsuchiya H, Noguchi Y, Sakashita H, Ide F, Kusama K: Expression of heparanase: a possible role in invasiveness and aggressive clinical behavior of ameloblastomas. J Oral Sci; 2010 Mar;52(1):39-47

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of heparanase: a possible role in invasiveness and aggressive clinical behavior of ameloblastomas.
  • In the present study, we carried out an immunohistochemical investigation of heparanase to extend and confirm present knowledge regarding its expression in ameloblastomas (AMs), which are characterized by locally aggressive behavior.
  • Small tumor nests and budding epithelial branches showed a stronger staining pattern.
  • However, an enhanced positive immunoreaction was present specifically near osseous tissue and adjacent to the invasive front of tumor nests.
  • The enzyme may facilitate the function of HS-binding growth factors that elicit an angiogenic response and favor osteoclastogenesis in AM.
  • [MeSH-major] Ameloblastoma / enzymology. Glucuronidase / biosynthesis. Jaw Neoplasms / enzymology

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  • (PMID = 20339231.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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5. Vallicioni J, Loum B, Dassonville O, Poissonnet G, Ettore F, Demard F: [Ameloblastomas]. Ann Otolaryngol Chir Cervicofac; 2007 Sep;124(4):166-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ameloblastomas].
  • OBJECTIVES: The aim of this work was to report on the clinical, radiological and histological characteristics of ameloblastomas concerning bone structures of the face, rare but not exceptional tumours, and to communicate our experience of their treatment.
  • MATERIAL AND METHODS: The authors reexamined six recent cases of patients presenting with ameloblastoma at the centre Antoine Lacassagne in Nice.
  • The diagnostic context, the treatment and the development of the disease are given in detail, emphasizing the frequency of local relapse of this histologically benign condition.
  • RESULTS: The study of these cases confirmed the benefit of surgical treatment of ameloblastoma.
  • [MeSH-major] Ameloblastoma / epidemiology. Ameloblastoma / pathology. Mandibular Neoplasms / epidemiology. Mandibular Neoplasms / pathology

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  • (PMID = 17673157.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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6. Sivapathasundharam B, Einstein A: Unicystic ameloblastoma with the presence of dentin. Indian J Dent Res; 2007 Jul-Sep;18(3):128-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unicystic ameloblastoma with the presence of dentin.
  • We present a case of unicystic ameloblastoma of the posterior mandible in a 28 year-old female, histologically showing luminal and intramural plexiform epithelial proliferation with typical dentin in the connective tissue capsule.
  • The characteristics of hard tissue formation in ameloblastomas reported in existing literature and the possible origin of the dentin mass seen in our case are discussed.
  • [MeSH-major] Ameloblastoma / pathology. Dentin / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17687176.001).
  • [ISSN] 0970-9290
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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7. Feng Y, Zhou YM, Hua CG, Tang XF, He DQ: Expression of Twist in different subtype of ameloblastomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Oct;108(4):565-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Twist in different subtype of ameloblastomas.
  • OBJECTIVE: The objective of this study was to investigate the pattern of Twist expression in a series of ameloblastomas, and to study the possible role of Twist in the bone destruction and local invasiveness of ameloblastoma variants.
  • STUDY DESIGN: Immunohistochemical study was performed for Twist protein in 53 ameloblastomas (32 solid/multicystic [SA] and 21 unicystic [UA]).
  • RESULTS: The salient finding was that expression of Twist was related to the histological subtype of tumors, as there was a higher expression in SA (14/32, 43.75%) as compared to UA (4/21, 19.05%) (P < .05).
  • CONCLUSIONS: Our results suggest that Twist expression might be associated with invasion in ameloblastoma variants, and stromal cells might play a regulatory role during tumor development.
  • [MeSH-major] Ameloblastoma / classification. Jaw Neoplasms / classification. Nuclear Proteins / analysis. Twist Transcription Factor / analysis

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  • (PMID = 19699120.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 0 / TWIST1 protein, human; 0 / Twist Transcription Factor
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8. Yavagal C, Anegundi RT, Shetty S: Unicystic plexiform ameloblastoma: an insight for pediatric dentists. J Indian Soc Pedod Prev Dent; 2009 Jan-Mar;27(1):70-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unicystic plexiform ameloblastoma: an insight for pediatric dentists.
  • Ameloblastomas have been categorized broadly into three biologic variants: cystic (unicystic), solid, and peripheral.
  • The term plexiform unicystic ameloblastoma refers to a pattern of epithelial proliferation that has been described in cystic lesions of the jaws.
  • Although the histology suggests that cystic ameloblastomas follow a biologically low-grade course, recent evidence suggests that they may often behave clinically as biologically aggressive tumors.
  • A literature review on the topic has been added along with a case report highlighting the state-of-the-art approach and management of such ameloblastomas, in pediatric patients.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 19414980.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 14
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9. Kumamoto H, Ohki K: Detection of Notch signaling molecules in ameloblastomas. J Oral Pathol Med; 2008 Apr;37(4):228-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of Notch signaling molecules in ameloblastomas.
  • BACKGROUND: To evaluate the roles of Notch signaling in the oncogenesis and cytodifferentiation of odontogenic tumors, expression of Notch receptors and ligands was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of nine tooth germs and 32 ameloblastomas were examined by reverse transcriptase polymerase chain reaction and by in situ hybridization to determine the expression of Notch1, Notch2, Notch3, Delta1, and Jagged1.
  • Ameloblastomas showed expression of Notch receptors and ligands in central polyhedral neoplastic cells.
  • Expression of Notch receptors and ligands was not found in keratinizing cells or granular cells in ameloblastoma variants.
  • CONCLUSION: Expression of Notch receptors and ligands in tooth germs and ameloblastomas suggests that Notch signaling might control cell differentiation and proliferation of normal and neoplastic odontogenic epithelium.
  • [MeSH-major] Ameloblastoma / chemistry. Intercellular Signaling Peptides and Proteins / analysis. Jaw Neoplasms / chemistry. Receptors, Notch / analysis. Tooth Germ / chemistry

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  • (PMID = 18221321.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Notch
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10. Sammartino G, Zarrelli C, Urciuolo V, di Lauro AE, di Lauro F, Santarelli A, Giannone N, Lo Muzio L: Effectiveness of a new decisional algorithm in managing mandibular ameloblastomas: a 10-years experience. Br J Oral Maxillofac Surg; 2007 Jun;45(4):306-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of a new decisional algorithm in managing mandibular ameloblastomas: a 10-years experience.
  • We present a new treatment algorithm aimed to assist surgeons to develop a rational diagnostic protocol and establish effective conservative surgical management in patients with mandibular ameloblastoma.
  • [MeSH-major] Algorithms. Ameloblastoma / surgery. Decision Support Techniques. Mandibular Neoplasms / surgery

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  • [CommentIn] Br J Oral Maxillofac Surg. 2008 Apr;46(3):257 [17904255.001]
  • (PMID = 17056165.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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11. da Silva TA, Batista AC, Mendonça EF, Leles CR, Fukada S, Cunha FQ: Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Mar;105(3):333-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts.
  • STUDY DESIGN: The expression of these molecules was evaluated in solid/multicystic ameloblastomas (n = 12) and unicystic ameloblastomas (n = 8), keratocystic odontogenic tumors (n = 19), dentigerous cysts (n = 9), and dental follicles (n = 9) by immunohistochemistry.
  • With regard to stroma, the number of RANK-positive and RANKL-positive cells was higher in solid/multicystic ameloblastomas compared with dentigerous cysts.
  • Dental follicles had lower numbers of RANK-positive, RANKL-positive, and OPG-positive cells than solid/multicystic ameloblastomas and keratocystic odontogenic tumors.
  • The majority of solid/multicystic ameloblastomas (75%) and unicystic ameloblastomas (62.5%) had higher numbers of RANKL-positive than OPG-positive cells.
  • [MeSH-minor] Ameloblastoma / metabolism. Ameloblastoma / pathology. Cell Count. Epithelial Cells / metabolism. Gene Expression. Humans. Osteolysis / pathology. Root Resorption / pathology. Statistics, Nonparametric. Stromal Cells / metabolism

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  • (PMID = 18061491.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / Osteoprotegerin; 0 / RANK Ligand
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12. Asaumi J, Hisatomi M, Yanagi Y, Matsuzaki H, Choi YS, Kawai N, Konouchi H, Kishi K: Assessment of ameloblastomas using MRI and dynamic contrast-enhanced MRI. Eur J Radiol; 2005 Oct;56(1):25-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of ameloblastomas using MRI and dynamic contrast-enhanced MRI.
  • We retrospectively evaluated magnetic resonance images (MRI) and dynamic contrast-enhanced MRI (DCE-MRI) of ameloblastomas.
  • MRI and DCE-MRI were performed for 10 ameloblastomas.
  • We obtained the following results from the MRI and DCE-MRI. (a) Ameloblastomas can be divided into solid and cystic portions on the basis of MR signal intensities. (b) Ameloblastomas show a predilection for intermediate signal intensity on T1WI, high signal intensity on T2WI, and well enhancement in the solid portion; they also show a homogeneous intermediate signal intensity on T1WI and homogeneous high signal intensity on T2WI, and no enhancement in the cystic portion. (c) The mural nodule or thick wall can be detected in ameloblastomas lesions. (d) CI curves of ameloblastomas show two patterns: the first pattern increases, reaches a plateau at 100-300 s, then sustains the plateau or decreases gradually to 600-900 s, while the other increases relatively rapidly, reaches a plateau at 90-120 s, then decreases relatively rapidly to 300 s, and decreases gradually thereafter.
  • There was no difference in the CI curve patterns among primary and recurrent cases, a case with glandular odontogenic tumor in ameloblastoma or among histopathological types such as plexiform, follicular, mixed, desmoplastic, and unicystic type.
  • [MeSH-major] Ameloblastoma / diagnosis. Gadolinium DTPA. Image Enhancement / methods. Jaw / pathology. Jaw Neoplasms / diagnosis. Magnetic Resonance Imaging / methods

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  • (PMID = 16168260.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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13. Bologna-Molina R, Mosqueda-Taylor A, Lopez-Corella E, de Almeida OP, Carrasco-Daza D, Farfán-Morales JE, Molina-Frechero N, Damián-Matsumura P: Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma. Pathol Int; 2009 Apr;59(4):229-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma.
  • The aims of the present study were to examine whether the pattern of syndecan-1 expression correlates with cellular proliferation index in desmoplastic ameloblastomas (DA), peripheral ameloblastomas (PA) and ameloblastic carcinomas (AC), and to compare with that previously reported for solid (SA) and unicystic (UA) variants of ameloblastoma.
  • Immunohistochemistry was performed for syndecan-1 and Ki-67 in seven ameloblastomas (four DA and three PA) and three AC.
  • Syndecan-1 expression correlated inversely with Ki-67 proliferative index: the expression was lower in both types of ameloblastomas (1.5% in DA and 6.4% in PA) than in AC (41.2%; P < 0.05).
  • These data suggest that DA differ from the other types of intraosseous ameloblastomas but more studies are necessary to better understand the role of this protein as a marker in the biological behavior of the epithelial odontogenic neoplasms.
  • [MeSH-major] Ameloblastoma / pathology. Carcinoma / pathology. Jaw Neoplasms / pathology. Ki-67 Antigen / biosynthesis. Syndecan-1 / biosynthesis

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  • (PMID = 19351365.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Syndecan-1
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14. Alves Pereira KM, do Amaral BA, dos Santos BR, Galvão HC, Freitas Rde A, de Souza LB: Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Mar;109(3):425-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs.
  • OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis.
  • STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin.
  • RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively).
  • The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively).
  • Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor).
  • CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas.
  • [MeSH-major] Ameloblastoma / metabolism. Cadherins / metabolism. Jaw Neoplasms / metabolism. Neoplasm Proteins / metabolism. Tooth Germ / metabolism. beta Catenin / metabolism

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20219600.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / Neoplasm Proteins; 0 / beta Catenin
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15. Kumamoto H, Ooya K: Expression of bone morphogenetic proteins and their associated molecules in ameloblastomas and adenomatoid odontogenic tumors. Oral Dis; 2006 Mar;12(2):163-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of bone morphogenetic proteins and their associated molecules in ameloblastomas and adenomatoid odontogenic tumors.
  • MATERIALS AND METHODS: Tooth germs, ameloblastomas, adenomatoid odontogenic tumors, and malignant ameloblastomas were examined by RT-PCR and immunohistochemistry for detection of BMP-2, -4, -7, BMP receptors I and II (BMPR-I, BMPR-II), core-binding factor alpha1 (CBFA1), and osterix.
  • Acanthomatous ameloblastomas showed increased BMP-7 reactivity in keratinizing cells.
  • [MeSH-major] Ameloblastoma / pathology. Bone Morphogenetic Proteins / analysis. Odontogenic Tumors / pathology

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  • (PMID = 16476038.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / BMP4 protein, human; 0 / BMP7 protein, human; 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Protein 4; 0 / Bone Morphogenetic Protein 7; 0 / Bone Morphogenetic Proteins; 0 / Core Binding Factor Alpha 1 Subunit; 0 / Sp7 protein, human; 0 / Transcription Factors; 0 / Transforming Growth Factor beta; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type II
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16. Adeyemo WL: Effectiveness of a new decisional algorithm in managing mandibular ameloblastomas. Br J Oral Maxillofac Surg; 2008 Apr;46(3):257

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of a new decisional algorithm in managing mandibular ameloblastomas.
  • [MeSH-major] Algorithms. Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Oral Surgical Procedures / methods

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  • [CommentOn] Br J Oral Maxillofac Surg. 2007 Jun;45(4):306-10 [17056165.001]
  • (PMID = 17904255.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Scotland
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17. Martano M, Damiano S, Restucci B, Paciello O, Russo V, Maiolino P: Nuclear morphometry in canine acanthomatous ameloblastomas and squamous cell carcinomas. Eur J Histochem; 2006 Apr-Jun;50(2):125-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nuclear morphometry in canine acanthomatous ameloblastomas and squamous cell carcinomas.
  • The aim of this study was to evaluate whether morphometrical analysis can be of diagnostic value for canine acanthomatous ameloblastoma.
  • We calculated, by means of an automated image analyser, some morphometric nuclear parameters, in particular: mean nuclear area (MNA), mean nuclear perimeter (MNP), maximum and minimum diameters (MDx and MDm) coefficient of variation of the nuclear area (NACV), largest to smallest dimension ratio (LS ratio), and form factor (FF), in 8 canine acanthomatous ameloblastomas, and we compared these morphometric data to those of 13 squamous cell carcinomas of canine gingiva.
  • The results indicated a progressive increase of the MNA, NACV, MNP and MDm proceeding from acanthomatous ameloblastomas (MNA: 42.11+/-8.74; NACV: 28,36+/-7,23; MNP: 24.18+/- 2.68; MDm: 5.69+/-0.49) to squamous cell carcinomas (MNA:49,69+/-9,10; NACV: 30,89+/-7,75; MNP: 25.63+/-2.54; MDm: 6.64+/-0.73).
  • On the contrary, the LS ratio and the FF resulted greater in acanthomatous ameloblastomas (LS ratio: 1,63+/-0,12; FF: 1,13+/-0,002) than in SCCs (LS ratio: 1,40+/-0,12; FF:0.91+/-0.38).
  • Moreover, the MNA, MNP,MDx and MDm resulted similar (MNA: p=0.89; MNP: p=0,65; MDm: p=0,16; MDx: p=0,13) in a subset of four acanthomatous ameloblastomas with cellular atypia (MNA:49,01+/-6,88; MNP: 26,28+/-1,99; MDm: 6.08+/-0.41; MDx: 10.18+/-0.88) and in squamous cell carcinomas (MNA:49.69+/-9,10; MNP: 25.63+/-2.54; MDm: 6.64+/-0.73; MDx: 9.26+/-1.05).
  • While the NACV values resulted higher in typical acanthomatous ameloblastoma (29,99+/-6,06) than in atypical acanthomatous ameloblastoma (26,74+/-8,84) and similar to those of the SCCs (30,89+/-7,75).
  • These results seem to confirm that acanthomatous ameloblastoma is a malignant or potentially malignant lesion and emphasizes that nuclear morphometry analysis can be an useful diagnostic and prognostic method in canine oral pathology.
  • [MeSH-major] Ameloblastoma / veterinary. Carcinoma, Squamous Cell / veterinary. Cell Nucleus / pathology. Dog Diseases / diagnosis. Gingiva / pathology. Jaw Neoplasms / veterinary

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  • (PMID = 16864123.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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18. Luo HY, Yu SF, Li TJ: Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. Int J Oral Maxillofac Surg; 2006 Aug;35(8):750-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas.
  • To evaluate the expression patterns of apoptosis-related proteins, including Fas, Fas-ligand (FasL), caspase-3 and Bcl-2, in various cellular components of ameloblastomas, 39 cases of ameloblastoma were examined using immunohistochemistry.
  • The differential expression of apoptosis-related proteins in various cellular components of ameloblastomas, with pro-apoptotic proteins, Fas, FasL and caspase-3 being closely associated with squamous metaplasia and granular transformation of the tumour cells, suggests that Fas/FasL-induced apoptotic cell death may play a role in the disposal of terminally differentiated or degenerative tumour cells in ameloblastomas.
  • [MeSH-major] Ameloblastoma / chemistry. Caspases / analysis. Jaw Neoplasms / chemistry. Membrane Glycoproteins / analysis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptors, Tumor Necrosis Factor / analysis. Tumor Necrosis Factors / analysis

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  • (PMID = 16690252.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / BCL2L15 protein, human; 0 / FAS protein, human; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factors; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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19. Fregnani ER, da Cruz Perez DE, de Almeida OP, Kowalski LP, Soares FA, de Abreu Alves F: Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas. Int J Oral Maxillofac Surg; 2010 Feb;39(2):145-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas.
  • The aim of this paper is to evaluate the clinical, radiographic, and histopathological findings and treatment modalities in all cases of ameloblastomas treated at the Sao Paulo Cancer Hospital, between 1953 and 2003.
  • 113 casees were solid ameloblastomas, and plexiforme subtype was the most common.
  • The ameloblastomas were predominantly solid, affecting the posterior mandible.
  • [MeSH-major] Ameloblastoma / epidemiology. Jaw Neoplasms / epidemiology

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  • [Copyright] Copyright 2009 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20045283.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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20. Crusoé-Rebello I, Oliveira C, Campos PS, Azevedo RA, dos Santos JN: Assessment of computerized tomography density patterns of ameloblastomas and keratocystic odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Oct;108(4):604-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of computerized tomography density patterns of ameloblastomas and keratocystic odontogenic tumors.
  • The aim of this study was to evaluate computerized tomography (CT) density patterns of solid ameloblastomas (SA), unicystic ameloblastomas (UA), and sporadic and multiple keratocystic odontogenic tumors (SK and MK, respectively).
  • [MeSH-major] Ameloblastoma / radiography. Jaw Neoplasms / radiography. Odontogenic Tumors / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 19464213.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Darshani Gunawardhana KS, Jayasooriya PR, Rambukewela IK, Tilakaratne WM: A clinico-pathological comparison between mandibular and maxillary ameloblastomas in Sri Lanka. J Oral Pathol Med; 2010 Mar;39(3):236-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinico-pathological comparison between mandibular and maxillary ameloblastomas in Sri Lanka.
  • BACKGROUND: The aim of this retrospective study was to analyse the relative prevalence and the clinico-pathological characteristics of mandibular and maxillary ameloblastomas in Sri Lanka.
  • METHODS: Clinico-pathological features of a total of 286 cases of ameloblastomas were analysed.
  • RESULTS: Out of the 286 cases, 87.8% (251/286) of ameloblastomas occurred in the mandible, while 10.8% (31/286) occurred in the maxilla indicating a ratio of 8:1.
  • In the mandible, 54% (136/251), 40% (100/251) and 6% (15/251) of tumours and in the maxilla, 23% (7/31), 48% (15/31) and 29% (9/31) of tumours were solid/multicystic ameloblastomas (SMA), unicystic ameloblastomas (UA) and desmoplastic ameloblastomas (DA) respectively.
  • No gender predilection was observed in mandibular or maxillary ameloblastomas.
  • No differences between mandibular and maxillary ameloblastomas were observed with reference to overall cellularity and mitotic activity.
  • Twenty-one percentage (60/286) of ameloblastomas presented with recurrences, and 94% (34/36) of these recurrences were observed in cases treated conservatively.
  • CONCLUSION: In conclusion, mandibular ameloblastomas were more prevalent than maxillary ameloblastomas, while no differences were observed in age or gender distribution between the mandibular and maxillary ameloblastomas.
  • [MeSH-major] Ameloblastoma / epidemiology. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology

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  • (PMID = 20070485.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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22. Iezzi G, Piattelli A, Rubini C, Artese L, Goteri G, Perrotti V, Carinci F: Expression of transforming growth factor beta1 in ameloblastomas. J Craniofac Surg; 2008 Nov;19(6):1618-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of transforming growth factor beta1 in ameloblastomas.
  • The aim of the present study was to compare the expression of transforming growth factor (TGF) beta1 in ameloblastomas (AMs) with different risk of recurrence by immunohistochemistry.
  • The increased TGF-beta1 expression in tumors with a high risk of recurrence could be explained with the fact that although TGF-beta acts as a potent tumor suppressor in the early stages of tumor progression, later it seems to enhance the invasive phenotype of the tumor.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology. Transforming Growth Factor beta1 / analysis

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  • (PMID = 19098564.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transforming Growth Factor beta1
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23. Kumamoto H, Ohki K, Ooya K: Expression of p63 and p73 in ameloblastomas. J Oral Pathol Med; 2005 Apr;34(4):220-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of p63 and p73 in ameloblastomas.
  • BACKGROUND: To clarify the role of p53 homologs in oncogenesis and cytodifferentiation of odontogenic tumors, expression of p63 and p73 was analyzed in ameloblastomas as well as tooth germs.
  • METHODS: Tissue specimens of nine tooth germs and 48 benign and five malignant ameloblastomas were examined by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) for the expression of p63 and p73.
  • RESULTS: Immunoreactivity for p63 and p73 was evident in epithelial cells neighboring the basement membrane in developing and neoplastic odontogenic tissues. p63 expression in desmoplastic ameloblastomas was significantly higher than in acanthomatous and granular cell ameloblastomas, and ameloblastic carcinomas showed higher p63 expression than metastasizing ameloblastomas. p73 expression was significantly higher in plexiform ameloblastomas than in follicular ameloblastomas, and basal cell ameloblastomas showed higher p73 expression than granular cell ameloblastomas. mRNA transcripts for Delta Np63 and TAp73 were detected in all developing and neoplastic odontogenic tissues.
  • TAp63 mRNA was expressed in five of eight tooth germs, 16 of 34 ameloblastomas, and one of one malignant ameloblastoma, whereas Delta Np73 mRNA was recognized in one of eight tooth germs, nine of 34 ameloblastomas, and one of one malignant ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Apoptosis / genetics. DNA-Binding Proteins / genetics. Genes, Tumor Suppressor. Nuclear Proteins / genetics. Phosphoproteins / genetics. Trans-Activators / genetics. Tumor Suppressor Proteins / genetics
  • [MeSH-minor] Basement Membrane / metabolism. Cell Differentiation / genetics. Cell Proliferation. Epithelial Cells / metabolism. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunohistochemistry. Protein Isoforms / genetics. Reverse Transcriptase Polymerase Chain Reaction. Tooth Germ / metabolism. Transcription Factors. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 15752257.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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24. Driemel O, Rieder J, Morsczeck C, Schwarz S, Hakim SG, Müller-Richter U, Reichert TE, Kosmehl H: [Comparison of clinical immunohistochemical findings in keratocystic odontogenic tumours and ameloblastomas considering their risk of recurrence]. Mund Kiefer Gesichtschir; 2007 Sep;11(4):221-31
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  • [Title] [Comparison of clinical immunohistochemical findings in keratocystic odontogenic tumours and ameloblastomas considering their risk of recurrence].
  • BACKGROUND: With the new term "keratocystic odontogenic tumour" (KCOT) keratocyts are even in the nomenclature a close differential diagnosis to ameloblastomas (A).
  • [MeSH-major] Ameloblastoma / pathology. Biomarkers, Tumor / analysis. Jaw Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17641919.001).
  • [ISSN] 1432-9417
  • [Journal-full-title] Mund-, Kiefer- und Gesichtschirurgie : MKG
  • [ISO-abbreviation] Mund Kiefer Gesichtschir
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Grim KC, Wolfe MJ, Edwards M, Kaufman J, Onjukka S, Moran P, Wolf JC: Epizootic ameloblastomas in Chinook salmon (Oncorhynchus tshawytscha) of the northwestern United States. Vet Pathol; 2009 Jul;46(4):622-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epizootic ameloblastomas in Chinook salmon (Oncorhynchus tshawytscha) of the northwestern United States.
  • Histologic features of the tumors suggested that they were derived from the portion of dental lamina destined to form tooth root sulci; therefore, these neoplasms were diagnosed as ameloblastomas.
  • Results of these efforts did not indicate an obvious genetic basis for this syndrome, attempts to isolate potentially causative viruses or bacteria were negative, and disease transmission to naïve fish was unsuccessful.
  • A few intracytoplasmic hexagonal structures, possibly consistent with viral particles (approximately 100 nm), were observed ultrastructurally in a tumor cell from 1 of 6 specimens submitted for transmission electron microscopy.
  • [MeSH-major] Ameloblastoma / veterinary. Disease Outbreaks / veterinary. Fish Diseases / epidemiology. Fish Diseases / pathology. Salmon

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  • (PMID = 19276053.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CB / N02-CB-27034
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Ledesma-Montes C, Mosqueda-Taylor A, Carlos-Bregni R, de León ER, Palma-Guzmán JM, Páez-Valencia C, Meneses-García A: Ameloblastomas: a regional Latin-American multicentric study. Oral Dis; 2007 May;13(3):303-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastomas: a regional Latin-American multicentric study.
  • AIM: To classify 163 ameloblastoma cases according to the new WHO Classification of Odontogenic Tumours (2005) and analyse their clinical and microscopic features.
  • METHODS: We studied the clinico-pathological features of 163 ameloblastoma cases from nine regional Latin-American institutions from Mexico and Guatemala.
  • RESULTS: Ameloblastomas comprised 22.7% of all odontogenic tumours.
  • The mean age was 41.4 years for solid ameloblastoma (SA) and 26.3 years for unicystic ameloblastoma (UA) (P < 0.001) and both sexes were almost equally affected.
  • CONCLUSIONS: In this study we found that UA was frequently misdiagnosed as SA; however, there are enough clinical and microscopic features that allow for an accurate differentiation between both types of ameloblastoma that should be recognized for surgical and prognostic purposes.
  • [MeSH-major] Ameloblastoma / classification. Ameloblastoma / pathology. Jaw Neoplasms / classification. Jaw Neoplasms / pathology

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  • (PMID = 17448213.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Denmark
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27. Alaeddini M, Salah S, Dehghan F, Eshghyar N, Etemad-Moghadam S: Comparison of angiogenesis in keratocystic odontogenic tumours, dentigerous cysts and ameloblastomas. Oral Dis; 2009 Sep;15(6):422-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of angiogenesis in keratocystic odontogenic tumours, dentigerous cysts and ameloblastomas.
  • MATERIALS AND METHODS: Microvessel density was assessed in a total of 53 cases including 20 keratocystic odontogenic tumours, 13 DCs and 20 ameloblastomas (14 solid and six unicystic variants).
  • RESULTS: Statistically significant differences in mean microvessel density were observed between keratocystic odontogenic tumours, DCs and solid ameloblastomas (P < 0.001).
  • Mean microvessel density was significantly higher in solid ameloblastomas compared with both keratocystic odontogenic tumours and DCs; and was also significantly higher in keratocystic odontogenic tumours than in DCs.
  • CONCLUSION: Within the limitations of the present study, it can be suggested that angiogenesis may be one of the mechanisms possibly contributing to the different biological behaviours of keratocystic odontogenic tumours, DCs and solid ameloblastomas.
  • [MeSH-major] Ameloblastoma / blood supply. Jaw Diseases / pathology. Jaw Neoplasms / blood supply. Neovascularization, Pathologic / pathology. Odontogenic Cysts / blood supply. Odontogenic Tumors / blood supply

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  • (PMID = 19413675.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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28. Niu CH, Li TJ: [Mutation and polymorphism of the ameloblastin gene in ameloblastomas]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Nov;41(11):678-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mutation and polymorphism of the ameloblastin gene in ameloblastomas].
  • OBJECTIVE: To investigate the presence of mutation or polymorphism of ameloblastin (AMBN) gene in ameloblastomas.
  • METHODS: Genomic DNA was extracted from frozen tissues of 10 ameloblastomas and one malignant ameloblastoma.
  • Restriction fragment length polymorphism (RFLP) analysis was used to further determine the nature of the changes in AMBN detected in tumor samples in comparison to 100 control samples.
  • RESULTS: AMBN mutation was not identified in all 11 tumor samples.
  • CONCLUSIONS: AMBN gene mutation is not identified in the present group of ameloblastomas.
  • The frequently detected AMBN alterations in ameloblastomas are polymorphisms, which appear to be unrelated to the occurrence of ameloblastomas.
  • [MeSH-major] Ameloblastoma / genetics. Dental Enamel Proteins / genetics. Jaw Neoplasms / genetics. Polymorphism, Genetic

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  • (PMID = 17331365.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AMBN protein, human; 0 / Dental Enamel Proteins
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29. Abu El-Naaj I, Emodi O, Peled M: Metachronous ameloblastomas in the maxilla and mandible: report of a case. J Craniomaxillofac Surg; 2005 Oct;33(5):349-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous ameloblastomas in the maxilla and mandible: report of a case.
  • Ameloblastoma is a locally aggressive tumour of odontogenic origin, with an unknown aetiology.
  • Metachronous ameloblastoma in the maxilla and the mandible is rare.
  • In this report, a case of a 63 year-old man is described with a solid ameloblastoma in the posterior part of the upper jaw.
  • Both ameloblastomas were of the solid type but differed in their histological patterns.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 16129610.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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30. Kumamoto H, Ooya K: Immunohistochemical detection of retinoblastoma protein and E2 promoter-binding factor-1 in ameloblastomas. J Oral Pathol Med; 2006 Mar;35(3):183-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical detection of retinoblastoma protein and E2 promoter-binding factor-1 in ameloblastomas.
  • BACKGROUND: To clarify the roles of cell cycle regulation in oncogenesis and cytodifferentiation of odontogenic tumors, expression of retinoblastoma protein (RB) and E2 promoter-binding factor-1 (E2F-1) was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against RB, E2F-1, and phosphorylated RB.
  • RESULTS: Immunohistochemical reactivity for RB, E2F-1, phosphorylated RB, and Ki-67 was detected in the nuclei of odontogenic epithelial cells near the basement membrane in tooth germs and benign and malignant ameloblastomas.
  • The levels of immunoreactivity for RB, E2F-1, phosphorylated RB, and Ki-67 were slightly higher in benign and malignant ameloblastomas than in tooth germs.
  • Plexiform ameloblastomas showed significantly higher expression of RB than follicular ameloblastomas.
  • Ki-67 immunoreactivity was significantly higher in ameloblastic carcinomas than in metastasizing ameloblastomas.
  • CONCLUSION: Similar immunoreactivity for RB, E2F-1, phosphorylated RB, and Ki-67 in tooth germs and ameloblastomas indicated cellular expression of phosphorylated RB and active-free E2F-1 in both normal and neoplastic odontogenic tissues.
  • [MeSH-major] Ameloblastoma / chemistry. E2F1 Transcription Factor / analysis. Retinoblastoma Protein / analysis

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  • (PMID = 16454815.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / E2F1 Transcription Factor; 0 / Ki-67 Antigen; 0 / Retinoblastoma Protein
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31. Kumamoto H, Ooya K: Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their associated molecules in ameloblastomas. J Oral Pathol Med; 2005 May;34(5):287-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their associated molecules in ameloblastomas.
  • BACKGROUND: To clarify the roles of the apoptosis signaling pathway mediated by death receptors in oncogenesis and cytodifferentiation of odontogenic tumors, expression of tumor necrosis factor alpha (TNFalpha), TNF-related apoptosis-inducing ligand (TRAIL), and their associated molecules was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of TNFalpha, TNF receptor I (TNFRI), TRAIL, TRAIL receptor 1 (TRAIL-R1), TRAIL-R2, caspase-8, and nuclear factor-kappaB (NF-kappaB).
  • Expression of caspase-8 mRNA was identified in six of 33 ameloblastomas, but not in 10 tooth germs or one malignant ameloblastoma.
  • Epithelial expression of TNFalpha was focal in about 50% of tooth germs and ameloblastomas, and TNFalpha expression in neoplastic cells was significantly higher in follicular ameloblastomas than in plexiform ameloblastomas.
  • Expression of caspase-8 was found in some neoplastic cells in three of 37 ameloblastomas, but not in 10 tooth germs or five malignant ameloblastomas.
  • CONCLUSION: Expression of TNFalpha, TRAIL, and their receptors in tooth germs and ameloblastomas suggests that these death factors might be involved in cytodifferentiation of odontogenic epithelium and tissue structuring of ameloblastomas.
  • [MeSH-major] Ameloblastoma / metabolism. Apoptosis. Jaw Neoplasms / metabolism. Membrane Glycoproteins / biosynthesis. Tumor Necrosis Factor-alpha / biosynthesis
  • [MeSH-minor] Apoptosis Regulatory Proteins. Caspase 8. Caspases / biosynthesis. Humans. Immunoenzyme Techniques. NF-kappa B / biosynthesis. RNA, Messenger / analysis. Receptors, TNF-Related Apoptosis-Inducing Ligand. Receptors, Tumor Necrosis Factor / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Statistics, Nonparametric. TNF-Related Apoptosis-Inducing Ligand. Tooth Germ / metabolism. Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism

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  • (PMID = 15817072.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Membrane Glycoproteins; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / Receptors, Tumor Necrosis Factor; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFRSF10A protein, human; 0 / TNFRSF10B protein, human; 0 / TNFSF10 protein, human; 0 / Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; 0 / Tumor Necrosis Factor-alpha; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases
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32. Ohtsuru M: Expression of parathyroid hormone-related protein in ameloblastomas. Tokai J Exp Clin Med; 2005 Dec;30(4):233-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of parathyroid hormone-related protein in ameloblastomas.
  • Parathyroid hormone-related protein (PTHrP) was first discovered as a causative protein for hypercalcemia, which is often seen in the malignant tumor.
  • The present study, therefore, sought to clarify the expression of PTHrP, parathyroid hormone (PTH) and PTH1R in ameloblastoma, using RT-PCR (N = 8), immunohistochemistry (N = 23) and ELISA (N = 11) techniques.
  • Expression of PTHrP was also seen in all of the 23 cases in ameloblastoma by immunohistochemistry.
  • PTH1R was observed on osteoblasts in bone around the tumor but no expression was observed on ameloblastoma cells in tumor parenchyma by immunohistochemistry.
  • PTH was not detected in ameloblastoma by RT-PCR, immunohistochemistory as well as ELISA.
  • In addition, hypercalcemia and increase of serum PTHrP level was observed in one case of 8 ameloblastomas.
  • It was suggested that PTHrP level may be associated with local bone infiltration and hypercalcemia in ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Ameloblastoma / metabolism. Jaw Neoplasms / genetics. Jaw Neoplasms / metabolism. Parathyroid Hormone-Related Protein / genetics. Parathyroid Hormone-Related Protein / metabolism

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  • (PMID = 16482944.001).
  • [ISSN] 0385-0005
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / PTH1R protein, human; 0 / Parathyroid Hormone; 0 / Parathyroid Hormone-Related Protein; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptor, Parathyroid Hormone, Type 1; 0 / Receptors, Parathyroid Hormone; SY7Q814VUP / Calcium
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33. Fregnani ER, Sobral LM, Alves FA, Soares FA, Kowalski LP, Coletta RD: Presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) in ameloblastomas correlate with rupture of the osseous cortical. Pathol Oncol Res; 2009 Jun;15(2):231-40
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  • [Title] Presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) in ameloblastomas correlate with rupture of the osseous cortical.
  • Myofibroblasts are frequent in the stroma of neoplasm and by the expression of proteinases they can influence tumor infiltration and progression.
  • In the present study, presence of myofibroblasts and expression of matrix metalloproteinase-2 (MMP-2) and urokinase plasminogen activator (uPA) were examined in intra-osseous solid multicystic ameloblastomas to determine their roles in the clinicopathological features of the tumors.
  • Fifty seven ameloblastomas were analyzed immunohistochemically with antibodies against the isoform alpha of the smooth muscle actin (alpha-SMA), a specific marker of myofibroblasts, MMP-2 and uPA.
  • Myofibroblasts were found in the stroma, in close contact with neoplastic cell islands, of approximately 58% (n = 33) of the ameloblastomas.
  • Abundant presence of myofibroblast in the stroma of the tumors and expression of MMP-2 in the neoplastic or stromal cells were significantly correlated with rupture of the osseous cortical, which has been considered an important prognostic marker of ameloblastoma aggressiveness.
  • Ours results suggest that abundant presence of myofibroblasts and expression of MMP-2 in solid ameloblastomas may be associated with a more aggressive infiltrative behavior.
  • [MeSH-major] Ameloblastoma / enzymology. Bone Neoplasms / enzymology. Fibroblasts / pathology. Matrix Metalloproteinase 2 / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / metabolism. Child. Cytoplasm / metabolism. Disease Progression. Female. Humans. Male. Middle Aged. Muscle, Smooth / enzymology. Prognosis. Stromal Cells / enzymology. Urokinase-Type Plasminogen Activator / metabolism. Young Adult

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  • (PMID = 19096916.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator; EC 3.4.24.24 / Matrix Metalloproteinase 2
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34. González-Alva P, Tanaka A, Oku Y, Miyazaki Y, Okamoto E, Fujinami M, Yoshida N, Kikuchi K, Ide F, Sakashita H, Kusama K: Enhanced expression of podoplanin in ameloblastomas. J Oral Pathol Med; 2010 Jan;39(1):103-9
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  • [Title] Enhanced expression of podoplanin in ameloblastomas.
  • In the present study, we carried out an immunohistochemical investigation of podoplanin to clarify whether it is expressed in human ameloblastomas (AMs), which are characterized by locally aggressive behavior with a high rate of recurrence.
  • RESULTS: Immunohistochemical reactivity for podoplanin was detected in the cell membrane and cytoplasm of most odontogenic tumor epithelial cells in AMs.
  • Immunoreactivity for E-cadherin was weak or negative in keratinizing cells of acanthomatous AMs, suggesting terminal differentiation of the tumor cells.
  • CONCLUSION: Expression of podoplanin in AMs is considered to be associated with neoplastic odontogenic tissues; this molecule might play a role in the collective cell migration of tumor nests in AMs.
  • [MeSH-major] Ameloblastoma / pathology. Membrane Glycoproteins / analysis

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  • (PMID = 19691459.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cadherins; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / Vimentin
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35. Gortzak RA, Latief BS, Lekkas C, Slootweg PJ: Growth characteristics of large mandibular ameloblastomas: report of 5 cases with implications for the approach to surgery. Int J Oral Maxillofac Surg; 2006 Aug;35(8):691-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growth characteristics of large mandibular ameloblastomas: report of 5 cases with implications for the approach to surgery.
  • The aim of this study was to establish surgical guidelines based on the growth pattern of ameloblastomas in relation to the possible infiltration of the cortical bone, the inferior alveolar nerve, the periosteal layer and the surrounding soft tissues.
  • Five male patients with voluminous mandibular ameloblastomas were treated by means of radical surgery.
  • Ameloblastomas showed an invasive growth pattern in the cancellous bone with small tumour nests at a maximum distance of 5mm away from the bulk of the tumour.
  • [MeSH-major] Ameloblastoma. Mandible. Mandibular Neoplasms. Practice Guidelines as Topic

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  • (PMID = 16580817.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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36. Sulzbacher I, Wick N, Pichlhofer B, Mazal PR: Expression of platelet-derived growth factor-AA and platelet-derived growth factor-alpha receptor in ameloblastomas. J Oral Pathol Med; 2008 Apr;37(4):235-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of platelet-derived growth factor-AA and platelet-derived growth factor-alpha receptor in ameloblastomas.
  • We investigated the expression of both proteins in ameloblastomas, to contribute the understanding of the potential role of the PDGF/PDGFR system in this odontogenic neoplasm.
  • METHOD: Twenty-nine specimens of ameloblastoma were analyzed for PDGF-AA and PDGFRA expression using immunohistochemistry.
  • RESULTS: PDGF-AA and PDGFRA expression were detectable in all cases with the exception of one tumor.
  • Unicystic ameloblastomas did not differ from solid tumors with regard to PDGF-AA, PDGFRA, and MIB-1 expression.
  • One tumor revealed a somatic mutation of exon 12 of the PDGFRA gene.
  • CONCLUSION: PDGF-AA and PDGFRA proteins are regularly expressed in variable levels in ameloblastomas, and somatic mutations of exon 12 and exon 18 of the PDGFRA gene are rare findings.
  • [MeSH-major] Ameloblastoma / metabolism. Jaw Neoplasms / metabolism. Platelet-Derived Growth Factor / biosynthesis. Receptor, Platelet-Derived Growth Factor alpha / biosynthesis

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  • (PMID = 18284546.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Antinuclear; 0 / Antibodies, Monoclonal; 0 / MIB-1 antibody; 0 / Platelet-Derived Growth Factor; 0 / platelet-derived growth factor A; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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37. Escande C, Chaine A, Menard P, Ernenwein D, Ghoul S, Bouattour A, Berdal A, Bertrand JC, Ruhin-Poncet B: A treatment algorithm for adult ameloblastomas according to the Pitié-Salpêtrière Hospital experience. J Craniomaxillofac Surg; 2009 Oct;37(7):363-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A treatment algorithm for adult ameloblastomas according to the Pitié-Salpêtrière Hospital experience.
  • During a 13-year period (from 1994 to 2007), in the Oral and Maxillofacial Surgery Department of the Pitié-Salpêtrière Hospital, 116 new cases of adult ameloblastomas, were analyzed for treatment composed against radiographic presentation, size, histological type.
  • Lenthly, a therapeutic algorithm is suggested for adult ameloblastomas that underlines the importance of the conservative enucleation treatment as far as possible.
  • [MeSH-major] Ameloblastoma / therapy. Decision Trees. Mandibular Neoplasms / therapy. Maxillary Neoplasms / therapy. Neoplasm Recurrence, Local / prevention & control

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  • (PMID = 19559625.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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38. Sandra F, Hendarmin L, Nakamura S: Osteoprotegerin (OPG) binds with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): suppression of TRAIL-induced apoptosis in ameloblastomas. Oral Oncol; 2006 Apr;42(4):415-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoprotegerin (OPG) binds with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): suppression of TRAIL-induced apoptosis in ameloblastomas.
  • Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) is a potent apoptosis-inducing ligand in ameloblastomas.
  • To investigate on the expression of OPG in ameloblastomas, immuhistochemistry, immunofluorescence and Western blot were performed.
  • From the immunohistochemistry results, we found that OPG was expressed in ameloblastoma tissues.
  • Expression of OPG was clearly seen in AM-1 cells by immunofluorescence as well.
  • Additionally, Western blot analysis confirmed OPG expression in ameloblastoma tissues and AM-1 cells.
  • As we suspected that the binding of OPG and TRAIL might cause the effect of TRAIL in inducing apoptosis in ameloblastomas, we combined the treatment of OPG and TRAIL in AM-1 cells.
  • These data suggest that by binding with TRAIL, OPG suppressed TRAIL's function in inducing apoptosis in ameloblastomas.
  • [MeSH-major] Ameloblastoma / metabolism. Jaw Neoplasms / metabolism. Osteoprotegerin / metabolism. TNF-Related Apoptosis-Inducing Ligand / metabolism

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  • (PMID = 16413220.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Osteoprotegerin; 0 / TNF-Related Apoptosis-Inducing Ligand
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39. Ngwenya SP, Raubenheimer EJ, Noffke CE: Internal morphology of ameloblastomas: a study of 24 resected specimens. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Nov;108(5):754-62

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Internal morphology of ameloblastomas: a study of 24 resected specimens.
  • OBJECTIVES: The objectives of this study were to describe the internal macroscopic architecture of resected specimens of ameloblastoma and to correlate the findings with radiographs and microscopic features.
  • STUDY DESIGN: Resection specimens of 24 ameloblastomas were retrieved from the files of the Department of Oral Pathology at the University of Limpopo.
  • RESULTS: Twenty-three ameloblastomas affected the mandible and 1 the maxilla and measured between 3.3 and 20 cm in greatest diameter.
  • CONCLUSIONS: The assessment of the cystic nature of ameloblastomas on 2-dimensional radiographs is inaccurate.
  • Intraluminal proliferations, in situ carcinomatous change, adenoid differentiation, stromal osteodentin, and bone deposits and desmoplasia were found to be focal rather than generalized phenomena in resection specimen of ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 19748290.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Leocata P, Villari D, Fazzari C, Lentini M, Fortunato C, Nicòtina PA: Syndecan-1 and Wingless-type protein-1 in human ameloblastomas. J Oral Pathol Med; 2007 Aug;36(7):394-9
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  • [Title] Syndecan-1 and Wingless-type protein-1 in human ameloblastomas.
  • BACKGROUND: Aberrant Wingless type 1 glycoprotein (Wnt) pathway in ameloblastomas and a role of syndecan-1 (SDC1) in activating Wnt signalling were perspected.
  • The aim of this study was to reveal the role of SDC1 and Wnt1 in intraosseous ameloblastomas (IA(s)).
  • METHODS: SDC1 and Wnt1 expressions were investigated in 29 ameloblastoma subtypes and seven tooth buds.
  • RESULTS: SDC1 immunostaining strongly depicted stromal cells, extracellular matrix (ECM) and basement membranes of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Syndecan-1 / analysis. Wnt1 Protein / analysis

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  • (PMID = 17617831.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / SDC1 protein, human; 0 / Syndecan-1; 0 / WNT1 protein, human; 0 / Wnt1 Protein
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41. Gao L, Li TJ: [In vitro study on bone resorption of odontogenic cysts and ameloblastomas]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 May;40(3):233-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [In vitro study on bone resorption of odontogenic cysts and ameloblastomas].
  • OBJECTIVE: To investigate the effect of bone resorption by odontogenic cysts and ameloblastomas in vitro.
  • METHODS: Fragments of odontogenic cysts (14 odontogenic keratocysts, 6 inflamed odontogenic keratocysts, 5 dentigerous cysts) and ameloblastomas (n = 7) were incubated in vitro for 24 h.
  • The supernatant of odontogenic cysts and ameloblastomas was measured for the bone resorption related factors such as IL-6, TNF-alpha, PGE(2), bone Gla-containing protein (BGP) and calcitonin (CT) by a radioimmunoassay system.
  • The inflamed odontogenic keratocyst group had a significantly higher calcium concentration than odontogenic keratocyst and ameloblastoma groups (P < 0.05).
  • IL-6 concentration in the inflamed and non-inflamed odontogenic keratocyst groups were significantly higher than that of ameloblastoma group (P < 0.05).
  • [MeSH-major] Ameloblastoma / physiopathology. Bone Resorption. Odontogenic Cysts / physiopathology

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  • (PMID = 15938889.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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42. Jiang LJ, Shao CK, He D, Li WG, Wu XZ, Cai DZ: [Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma]. Ai Zheng; 2008 Dec;27(12):1263-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma].
  • BACKGROUND & OBJECTIVE: Matrix metalloproteinases (MMPs) are involved in local invasion of ameloblastomas.
  • This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts.
  • METHODS: EMMPRIN expression and MVD in 41 specimens of ameloblastoma and 40 specimens of odontogenic cyst were examined by SP immuno-histochemistry.
  • RESULTS: EMMPRIN was detected in all specimens of ameloblastomas and odontogenic cysts.
  • The strong positive rate of EMMPRIN was significantly higher in ameloblastomas than in odontogenic cysts (85.4% vs. 62.5%, P<0.05).
  • CONCLUSION: EMMPRIN may play an important role during the progression of ameloblastoma via controlling angiogenesis and degradation of extracellular MMPs.
  • [MeSH-major] Ameloblastoma / metabolism. Antigens, CD147 / metabolism. Jaw Neoplasms / metabolism. Microvessels / pathology

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  • (PMID = 19079990.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 136894-56-9 / Antigens, CD147
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43. Kumamoto H, Ooya K: Immunohistochemical detection of beta-catenin and adenomatous polyposis coli in ameloblastomas. J Oral Pathol Med; 2005 Aug;34(7):401-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical detection of beta-catenin and adenomatous polyposis coli in ameloblastomas.
  • BACKGROUND: To clarify the roles of the Wnt signaling pathway in oncogenesis and cytodifferentiation of odontogenic tumors, expression of beta-catenin and adenomatous polyposis coli (APC) was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against beta-catenin and APC.
  • RESULTS: Immunohistochemical reactivity for beta-catenin was detected in the cell membrane and cytoplasm of most odontogenic epithelial cells in tooth germs and ameloblastomas.
  • Nuclear beta-catenin expression was recognized in nine of 40 ameloblastomas and two of five malignant ameloblastomas, but not in tooth germs.
  • APC was evidently expressed in odontogenic epithelial cells neighboring the basement membrane in tooth germs and ameloblastomas, and the reactivity was significantly lower in benign and malignant ameloblastomas than in tooth germs.
  • Follicular ameloblastomas and acanthomatous ameloblastomas tended to show high nuclear beta-catenin expression and low APC reactivity, as compared with other ameloblastoma variants.
  • CONCLUSION: Expression of beta-catenin and APC in tooth germs and ameloblastomas suggests that aberration of the Wnt signaling pathway might play a role in oncogenesis and cytodifferentiation of odontogenic epithelium via deregulation of cell proliferation.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / analysis. Ameloblastoma / chemistry. Cytoskeletal Proteins / analysis. Jaw Neoplasms / chemistry. Trans-Activators / analysis

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  • (PMID = 16011608.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / CTNNB1 protein, human; 0 / CTNNB1 protein, mouse; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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44. Payeras MR, Sant'Ana Filho M, Lauxen IS, Barbachan JJ: Quantitative analysis of argyrophilic nucleolar organizer regions and epidermal growth factor receptor in ameloblastomas. J Oral Pathol Med; 2007 Feb;36(2):99-104
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  • [Title] Quantitative analysis of argyrophilic nucleolar organizer regions and epidermal growth factor receptor in ameloblastomas.
  • OBJECTIVE: The aim of this study was to evaluate the proliferation activity by means of the quantification of the argyrophilic nucleolar organizer regions (AgNORs) and the patterns of expression of the epidermal growth factor receptor (EGFR) in ameloblastomas.
  • METHOD: The methods of evaluation included the H/E stain for the morphologic analysis, the silver impregnation technique for quantification of the AgNORs and the immunohistochemical stain with anti-EGFR antibody in 11 cases of ameloblastoma.
  • The expression of the EGFR on the epithelial islands of ameloblastoma was not uniform, and the location of the expression was also variable.
  • CONCLUSION: The tumor presents an irregular growth.
  • Smaller islands are associated with a higher proliferation activity and therefore could be responsible for tumor infiltration.
  • [MeSH-major] Ameloblastoma / chemistry. Antigens, Nuclear / analysis. Jaw Neoplasms / chemistry. Neoplasm Proteins / analysis. Nuclear Proteins / analysis. Receptor, Epidermal Growth Factor / analysis

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  • (PMID = 17238972.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / nucleolar organizer region associated proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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45. de Souza Andrade ES, Miguel MC, de Almeida Freitas R, Pereira Pinto L, Batista de Souza L: Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs. Int J Surg Pathol; 2008 Jul;16(3):277-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs.
  • The expression of integrins alpha2beta1, alpha3beta1, and alpha5beta1 in 30 ameloblastomas (20 solid and 10 unicystic tumors), 12 adenomatoid odontogenic tumors (AOTs), and 5 human tooth germs in different stages of odontogenesis was analyzed.
  • No difference in the immunoexpression of the integrins was observed between solid and unicystic ameloblastomas.
  • When these two ameloblastoma types were pooled into a single group, the following significant differences were found: immunoexpression of integrin alpha2beta1 was stronger in ameloblastomas than in AOTs and tooth germs, and the expression of integrin alpha5beta1 was stronger in ameloblastomas than in AOTs.
  • [MeSH-major] Ameloblastoma / metabolism. Biomarkers, Tumor / metabolism. Jaw Neoplasms / metabolism. Receptors, Collagen / metabolism. Tooth Germ / metabolism

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  • (PMID = 18573784.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Integrin alpha2beta1; 0 / Integrin alpha3beta1; 0 / Integrin alpha5beta1; 0 / Receptors, Collagen
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46. Curtis NJ, Zoellner H: Surgical management of an ameloblastoma in soft tissues of the cheek. Br J Oral Maxillofac Surg; 2006 Dec;44(6):495-6
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  • [Title] Surgical management of an ameloblastoma in soft tissues of the cheek.
  • Ameloblastomas are usually found in the bony tissues of the jaws, but have also been reported in the adjacent soft tissues.
  • Here we report the unusual occurrence of an extraosseous ameloblastoma in the tissues of the cheek.
  • [MeSH-major] Ameloblastoma / surgery. Cheek / surgery. Mouth Neoplasms / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 16338033.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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47. Kumamoto H, Ooya K: Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors. Oral Dis; 2007 Sep;13(5):461-7
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  • METHODS: 11 tooth germs, 40 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with antibodies against pAkt, PI3K, and PTEN.
  • Plexiform ameloblastomas showed significantly higher expression of PI3K than follicular ameloblastomas, and PI3K immunoreactivity in ameloblastomas without cellular variation was significantly higher than that in acanthomatous ameloblastomas.
  • The level of PTEN immunoreactivity was significantly lower in ameloblastomas than in tooth germs.
  • [MeSH-major] Ameloblastoma / chemistry. Jaw Neoplasms / chemistry. Membrane Proteins / analysis. Oncogene Protein v-akt / analysis. PTEN Phosphohydrolase / analysis

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  • (PMID = 17714348.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 2.7.11.1 / Oncogene Protein v-akt; EC 3.1.3.48 / TPTE protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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48. Souza Andrade ES, da Costa Miguel MC, Pinto LP, de Souza LB: Ameloblastoma and adenomatoid odontogenic tumor: the role of alpha2beta1, alpha3beta1, and alpha5beta1 integrins in local invasiveness and architectural characteristics. Ann Diagn Pathol; 2007 Jun;11(3):199-205

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma and adenomatoid odontogenic tumor: the role of alpha2beta1, alpha3beta1, and alpha5beta1 integrins in local invasiveness and architectural characteristics.
  • Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and a tendency toward recurrence, whereas adenomatoid odontogenic tumor (AOT) is an indolent neoplasm.
  • Paraffin-embedded specimens from 30 ameloblastomas (20 solid and 10 unicystic tumors) and 12 AOTs were submitted to immunohistochemistry using the catalyzed signal amplification system.
  • A difference in the pattern of integrin expression was observed between the various histologic types of ameloblastoma.
  • No significant difference in labeling intensity was observed between unicystic and solid ameloblastomas, but comparison between ameloblastomas and AOT showed a significantly stronger expression of alpha5beta1 integrin in the former (P < .05).
  • Our findings suggest an important role of the integrins studied in the architectural characteristics of ameloblastomas and AOTs and a possible participation of alpha5beta1 integrin in the mechanism of local invasion of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Integrin alpha2beta1 / physiology. Integrin alpha3beta1 / physiology. Integrin alpha5beta1 / physiology. Jaw Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17498594.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Integrin alpha2beta1; 0 / Integrin alpha3beta1; 0 / Integrin alpha5beta1
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49. Kumamoto H, Ooya K: Immunohistochemical detection of phosphorylated JNK, p38 MAPK, and ERK5 in ameloblastic tumors. J Oral Pathol Med; 2007 Oct;36(9):543-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Ten tooth germs, 47 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with the antibodies against p-JNK, p-p38 MAPK, and p-ERK5.
  • RESULTS: Immunoreactivity for p-JNK was detected in epithelial or neoplastic cells detached from the basement membrane in 7 tooth germs and 7 ameloblastomas, and the expression levels of p-JNK in ameloblastic tumors were significantly lower than that in tooth germs.
  • Expression of p-p38 MAPK was found in epithelial or neoplastic cells in tooth germs and ameloblastic tumors except for two ameloblastomas, and increased expression was found in keratinizing cells of acanthomatous ameloblastomas.
  • The expression level of p-p38 MAPK in ameloblastomas was significantly higher than the levels in tooth germs and malignant ameloblastic tumors.
  • The expression levels of p-ERK5 in ameloblastic tumors were slightly higher than that in tooth germs, and plexiform ameloblastomas showed significantly higher p-ERK5 expression than follicular ameloblastomas.
  • Altered expression of these phosphorylated MAPKs in ameloblastic tumors may be involved in oncogenesis and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / enzymology. Jaw Neoplasms / enzymology. Mitogen-Activated Protein Kinases / metabolism. Tooth Germ / enzymology

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  • (PMID = 17850438.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 7; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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50. Correnti M, Rossi M, Avila M, Perrone M, Rivera H: Human papillomavirus in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Sep;110(3):e20-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus in ameloblastoma.
  • OBJECTIVE: Ameloblastomas are benign epithelial tumors of odontogenic origin, with a high recurrence rate and local aggressiveness.
  • A few preliminary studies have demonstrated HPV presence mainly in peripheral ameloblastomas.
  • The purpose of this study was to detect HPV-DNA in intraosseous ameloblastomas.
  • METHODS: Eighteen cases of intraosseous ameloblastomas of different histological variants were selected.
  • Four of the unicystic ameloblastomas were HPV positive; of these, all presented koilocytic changes and were associated with dentigerous cysts, whereas only 2 positive cases corresponded to solid ameloblastomas.
  • CONCLUSIONS: We may conclude that HPV low and high risk was detected in our sample of intraosseous ameloblastomas.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Ameloblastoma / virology. Mandibular Neoplasms / virology. Papillomavirus Infections / diagnosis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20727492.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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51. Chen WL, Ouyang KX, Li HG, Huang ZQ, Li JS, Wang JG: Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma. J Craniofac Surg; 2009 Jan;20(1):171-5; discussion 176-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma.
  • The purposes of this study were to determine the correlation between the expression of inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) in ameloblastoma and to examine the relationships of this expression to angiogenesis and the clinical and biological behaviors of the tumor.
  • Immunohistochemical staining with streptavidin peroxidase was used to analyze iNOS and VEGF expression, and CD34 was used to evaluate microvascular density (MVD) in 35 ameloblastomas (24 primary tumors and 11 recurrences) and 5 malignant ameloblastomas.
  • On relational analysis, positive and VEGF expression and MVD counts increased in this order: OKCs, primary ameloblastoma, recurrent ameloblastoma, and malignant ameloblastoma.
  • Differences between the ameloblastomas and OKCs were significant (P < 0.05).
  • Among ameloblastomas, MVD counts increased with increasing expression of iNOS and VEGF (P < 0.05), and iNOS expression and VEGF expression were positively correlated (r = 0.66, P < 0.05).
  • Inducible nitric oxide synthase expression and VEGF expression may be closely related to the angiogenesis and invasive biological behavior of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Neovascularization, Pathologic / pathology. Nitric Oxide Synthase Type II / analysis. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 19165019.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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52. Kumamoto H, Ooya K: Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. J Oral Pathol Med; 2006 Jul;35(6):345-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 11 tooth germs, 40 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against MT1-MMP, RECK, and EMMPRIN.
  • RECK expression was lower in ameloblastomas than in tooth germs.
  • Follicular ameloblastomas showed significantly lower expression of RECK than plexiform ameloblastomas, and immunoreactivity for RECK in acanthomatous ameloblastomas was slightly lower than that in other cellular variants.
  • CONCLUSION: Expression of MT1-MMP, RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control MMP-dependent extracellular matrix (ECM) degradation during tooth development and tumor progression via epithelial-mesenchymal interactions.
  • [MeSH-major] Ameloblastoma / chemistry. Antigens, CD147 / analysis. Jaw Neoplasms / chemistry. Matrix Metalloproteinases / analysis. Membrane Glycoproteins / analysis. Tooth Germ / chemistry

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  • (PMID = 16762015.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / RECK protein, human; 136894-56-9 / Antigens, CD147; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases, Membrane-Associated
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53. Miyake T, Tanaka Y, Kato K, Tanaka M, Sato Y, Ijiri R, Inayama Y, Ito Y, Aoki S, Kawabe R, Tohnai I: Gene mutation analysis and immunohistochemical study of beta-catenin in odontogenic tumors. Pathol Int; 2006 Dec;56(12):732-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Six ameloblastomas (five follicular ameloblastomas and one plexiform ameloblastoma) and three malignant odontogenic tumors (one metastasizing ameloblastoma, one ameloblastic carcinoma, and one primary intraosseous odontogenic carcinoma) were investigated for CTNNB1 expression and CTNNB1 mutation.
  • Immunohistochemically, all follicular ameloblastomas and one primary intraosseous odontogenic carcinoma exhibited focal and moderate nuclear/cytoplasmic expression of CTNNB1, whereas the plexiform ameloblastoma and the remaining two malignant odontogenic tumors had entirely membranous expression.
  • CTNNB1 mutation at codon 40 of exon 3 was found in one of the six follicular ameloblastomas.
  • The other five follicular ameloblastomas, the plexiform ameloblastoma, and the three malignant odontogenic tumors did not show mutation in exon 3 of CTNNB1.
  • These findings further confirmed that CTNNB1 mutation is not frequent in ameloblastoma and malignant odontogenic tumors, although the abnormality of Wnt signaling may be associated with some of these tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / genetics. Ameloblastoma / pathology. Base Sequence. Child. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Molecular Sequence Data. Polymerase Chain Reaction

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  • (PMID = 17096730.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / beta Catenin
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54. Kumamoto H, Ooya K: Immunohistochemical detection of BH3-only proteins in ameloblastic tumors. Oral Dis; 2008 Sep;14(6):550-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Nine tooth germs, 37 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with antibodies against Bid, Bim, Bad, Noxa, and Puma.
  • Acanthomatous ameloblastomas showed no reactivity for Bid, Bim, Bad, Noxa, or Puma in keratinizing cells, whereas granular cells in granular cell ameloblastomas reacted with these BH3-only proteins.
  • Basal and desmoplastic ameloblastomas and ameloblastic carcinomas showed immunoreactivity for the BH3-only proteins in most neoplastic cells.
  • Distinctive expression patterns of these BH3-only proteins in ameloblastoma variants suggest that the BH3-only proteins might be involved in tumor cell differentiation of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis Regulatory Proteins / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis

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  • (PMID = 18826384.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BAD protein, human; 0 / BBC3 protein, human; 0 / BH3 Interacting Domain Death Agonist Protein; 0 / BID protein, human; 0 / Bcl-2-like protein 11; 0 / Membrane Proteins; 0 / PMAIP1 protein, human; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-Associated Death Protein; 68238-35-7 / Keratins
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55. Kumamoto H, Ooya K: Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors. J Oral Pathol Med; 2006 Nov;35(10):606-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 11 tooth germs, 44 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against PD-ECGF/TP and angiopoietin-1 and -2.
  • RESULTS: Immunohistochemical reactivity for PD-ECGF/TP was detected in mesenchymal cells in tooth germs and stromal cells in ameloblastic tumors, and the level of immunoreactivity for PD-ECGF/TP was significantly higher in ameloblastomas than in tooth germs.
  • Granular cell ameloblastomas showed PD-ECGF/TP reactivity in granular neoplastic cells as well as in stromal cells.
  • Malignant ameloblastic tumors had decreased angiopoietin-1 reactivity and ameloblastic carcinomas had increased angiopoietin-2 reactivity as compared with the respective levels in tooth germs and ameloblastomas.
  • Immunohistochemical reactivity for angiopoietin-2 was slightly higher in follicular ameloblastomas than in plexiform ameloblastomas.
  • CONCLUSION: Expression of PD-ECGF/TP and angiopoietin-1 and -2 in tooth germs and ameloblastic tumors suggests that these angiogenic factors participate in tooth development and odontogenic tumor progression by regulating angiogenesis.
  • Altered expression of PD-ECGF/TP and angiopoietins in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / chemistry. Angiopoietin-1 / analysis. Angiopoietin-2 / analysis. Jaw Neoplasms / chemistry. Thymidine Phosphorylase / analysis

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  • (PMID = 17032393.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ANGPT1 protein, human; 0 / Angiopoietin-1; 0 / Angiopoietin-2; EC 2.4.2.4 / Thymidine Phosphorylase
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56. Brooks JK, Al-Mubarak H, Ribera MJ, Cohen PD, Ross DS, Scheper MA: Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma. Quintessence Int; 2010 Mar;41(3):209-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma.
  • Ameloblastomas are benign aggressive odontogentic tumors that exhibit insidious growth rates with attainment of extensive dimesions.
  • Because ameloblastomas are not usually symptomatic until late in their clinical course, few are detected early.
  • This article reports an atypical case of a small, painful ameloblastoma arising between the roots of the mandibular left canine and lateral incisor in a 66-year-old female.
  • Histopathology revealed a "hybrid" ameloblastoma with a pronounced desmoplastic pattern and acanthomatous changes.
  • Timely recognition and intervention of ameloblastomas may improve treatment outcomes.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 20213021.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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57. Kalavrezos N, Baldwin DJ, Walker DM: Giant neglected ameloblastoma: single stage treatment and clinicopathological review. Br J Oral Maxillofac Surg; 2008 Oct;46(7):591-3
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  • [Title] Giant neglected ameloblastoma: single stage treatment and clinicopathological review.
  • Giant ameloblastomas may present with massive swelling of the jaws.
  • We report a giant ameloblastoma of the mandible in a Nigerian patient that measured 15.1x12.2x13.6cm and was managed with a single procedure.
  • Single stage treatment that establishes early functional and aesthetic recovery offers advantages over multi staged procedures, and is therefore the treatment of choice for giant ameloblastomas.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Reconstructive Surgical Procedures / methods

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  • (PMID = 18343546.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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58. de Medeiros AM, Nonaka CF, Galvão HC, de Souza LB, Freitas Rde A: Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors. Eur Arch Otorhinolaryngol; 2010 Feb;267(2):303-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors.
  • This study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors.
  • Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT.
  • Solid ameloblastomas showed intense expression of fibronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of fibronectin at this site.
  • Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface.
  • AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen.
  • The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs.
  • Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.
  • [MeSH-major] Adenomatoid Tumor / metabolism. Ameloblastoma / metabolism. Collagen Type I / biosynthesis. Fibronectins / biosynthesis. Jaw Neoplasms / metabolism. Odontogenic Tumors / metabolism. Tenascin / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / biosynthesis. Extracellular Matrix Proteins / biosynthesis. Humans. Immunohistochemistry. Prognosis

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  • (PMID = 19466441.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Collagen Type I; 0 / Extracellular Matrix Proteins; 0 / Fibronectins; 0 / Tenascin
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59. Bello IO, Soini Y, Slootweg PJ, Salo T: Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth. J Oral Pathol Med; 2007 Jan;36(1):48-54
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  • [Title] Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth.
  • BACKGROUND: To analyze the distribution pattern of claudins 1, 4, 5, 7 and occludin in benign and malignant ameloblastomas and developing human teeth.
  • METHODS: Paraffin-embedded tissue specimens of 25 benign and four malignant ameloblastomas and two developing human teeth were examined immunohistochemically using antibodies against claudins 1, 4, 5, 7 and occludin.
  • RESULTS: In ameloblastomas strongest expression was seen for claudins 1 and 7 while claudin 4 was expressed less frequently.
  • There were no evident differences in the expression of claudins or occludin neither between different histologic subtypes of ameloblastomas nor between benign or malignant cases.
  • The strongest expression for claudins was present in the central stellatum reticulum-like cells surrounding the microcysts and in the areas with squamous differentiation of the ameloblastomas.
  • Claudin 5 was preferentially expressed only in vessels, and occludin staining ranged from negative to weak in ameloblastomas and teeth germs.
  • [MeSH-major] Ameloblastoma / pathology. Membrane Proteins / analysis. Odontogenesis / physiology. Tight Junctions / pathology. Tooth Germ / pathology

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  • (PMID = 17181742.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / CLDN4 protein, human; 0 / CLDN5 protein, human; 0 / CLDN7 protein, human; 0 / Claudin-1; 0 / Claudin-4; 0 / Claudin-5; 0 / Claudins; 0 / Membrane Proteins; 0 / OCLN protein, human; 0 / Occludin
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60. Pogrel MA, Montes DM: Is there a role for enucleation in the management of ameloblastoma? Int J Oral Maxillofac Surg; 2009 Aug;38(8):807-12
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  • [Title] Is there a role for enucleation in the management of ameloblastoma?
  • This study aimed to determine the appropriate long-term management for ameloblastoma and the role of enucleation in the management of the subtypes of ameloblastoma (solid ameloblastomas, cystic ameloblastomas and peripheral ameloblastomas).
  • Solid and multicystic ameloblastomas have a high recurrence rate (60-80%) with simple enucleation and require more aggressive treatment.
  • For the unicystic ameloblastoma recurrence rates are high for simple enucleation.
  • The intraluminal subtype of unicystic ameloblastoma may do well with enucleation, but the intramural subtype may not, and since these cannot be identified preoperatively more aggressive treatment is recommended, including peripheral ostectomy or enucleation with subsequent treatment of the surrounding bone with liquid nitrogen, Carnoy's solution, or similar physicochemical modality.
  • The peripheral ameloblastoma has a different origin and responds to local excision.
  • [MeSH-major] Ameloblastoma / surgery. Jaw Neoplasms / surgery

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  • (PMID = 19297131.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carnoy's solution; 3K9958V90M / Ethanol; 7V31YC746X / Chloroform; Q40Q9N063P / Acetic Acid
  • [Number-of-references] 60
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61. Kumamoto H, Ooya K: Immunohistochemical detection of insulin-like growth factors, platelet-derived growth factor, and their receptors in ameloblastic tumors. J Oral Pathol Med; 2007 Apr;36(4):198-206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 47 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against IGF-I, IGF-II, IGF-I receptor (IGF-IR), PDGF A-chain, PDGF B-chain, PDGF alpha-receptor, and PDGF beta-receptor.
  • Malignant ameloblastic tumors showed higher reactivity for PDGF chains than benign ameloblastomas and higher reactivity for platelet-derived growth factor receptors than tooth germs.
  • The expression levels of PDGF chains were significantly higher in follicular ameloblastomas than in plexiform ameloblastomas.
  • Desmoplastic ameloblastomas showed higher expression of IGFs and IGF-IR when compared with other ameloblastoma subtypes.
  • Altered expression of the ligands and receptors in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / metabolism. Insulin-Like Growth Factor I / biosynthesis. Insulin-Like Growth Factor II / biosynthesis. Jaw Neoplasms / metabolism. Platelet-Derived Growth Factor / biosynthesis. Tooth Germ / metabolism

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  • (PMID = 17391297.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / Receptors, Somatomedin; 0 / platelet-derived growth factor A; 67763-96-6 / Insulin-Like Growth Factor I; 67763-97-7 / Insulin-Like Growth Factor II; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
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62. Gilijamse M, Leemans CR, Winters HA, Schulten EA, van der Waal I: Metastasizing ameloblastoma. Int J Oral Maxillofac Surg; 2007 May;36(5):462-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing ameloblastoma.
  • Ameloblastomas are locally invasive tumours of odontogenic origin with a high propensity for local recurrence.
  • Here is presented a case of a 26-year-old woman with a recurrent ameloblastoma of the mandible and a metastatic lymph node in the homolateral neck.
  • [MeSH-major] Ameloblastoma / secondary. Lymphatic Metastasis / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17275258.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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63. de Vicente JC, Torre-Iturraspe A, Gutiérrez AM, Lequerica-Fernández P: Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e709-15
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  • OBJECTIVES: The present study was undertaken to compare the pattern of expression of EGFR, cyclin D1, Ki-67, p-53 and carcinoembryonic antigen (CEA) in the epithelial lining of odontogenic keratocysts, dentigerous cysts, radicular cysts and ameloblastomas.
  • METHODS: four micrometers, formalin-fixed, paraffin-embedded tissue sections from 11 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts and 10 ameloblastomas were immunohistochemically studied.
  • RESULTS: There were statistically significant differences between cyclin D1 expression in odontogenic keratocysts and radicular cysts (p=0.001) and ameloblastomas (p=0.04).
  • In dentigerous cysts this mean was of 17%, of 15.5% in RC and of 7.8 in ameloblastomas.

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  • (PMID = 20383104.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Spain
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64. Ruhin-Poncet B, Ghoul-Mazgar S, Hotton D, Capron F, Jaafoura MH, Goubin G, Berdal A: Msx and dlx homeogene expression in epithelial odontogenic tumors. J Histochem Cytochem; 2009 Jan;57(1):69-78

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Epithelial odontogenic tumors are rare jaw pathologies that raise clinical diagnosis and prognosis dilemmas notably between ameloblastomas and clear cell odontogenic carcinomas (CCOCs).
  • In line with previous studies, the molecular determinants of tooth development-amelogenin, Msx1, Msx2, Dlx2, Dlx3, Bmp2, and Bmp4-were analyzed by RT-PCR, ISH, and immunolabeling in 12 recurrent ameloblastomas and in one case of CCOC.
  • Although Msx1 expression imitates normal cell differentiation in these tumors, other genes showed a distinct pattern depending on the type of tumor and the tissue involved.
  • In benign ameloblastomas, ISH localized Dlx3 transcripts and inconstantly detected Msx2 transcripts in epithelial cells.
  • Furthermore, while exploring the expression pattern of signal molecules by RT-PCR, Bmp2 was shown to be completely inactivated in the CCOC and irregularly noticeable in ameloblastomas.
  • [MeSH-minor] Adolescent. Adult. Ameloblastoma / metabolism. Bone Morphogenetic Protein 2 / biosynthesis. Bone Morphogenetic Protein 4 / biosynthesis. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. In Situ Hybridization. Male. Middle Aged. Neoplasm Recurrence, Local. Reverse Transcriptase Polymerase Chain Reaction. Young Adult

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  • (PMID = 18854600.001).
  • [ISSN] 0022-1554
  • [Journal-full-title] The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • [ISO-abbreviation] J. Histochem. Cytochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / BMP4 protein, human; 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Protein 4; 0 / Distal-less homeobox proteins; 0 / Homeodomain Proteins; 0 / MSX1 Transcription Factor; 0 / MSX2 protein; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC2605714
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65. Kumamoto H, Ohki K: Detection of CD133, Bmi-1, and ABCG2 in ameloblastic tumors. J Oral Pathol Med; 2010 Jan;39(1):87-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 12 tooth germs, 47 ameloblastomas, and six malignant ameloblastic tumors were examined using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of CD133, Bmi-1, and ABCG2.
  • Immunohistochemical reactivity for CD133 and Bmi-1 was evident in odontogenic epithelial cells neighboring the basement membrane in tooth germs, ameloblastomas, and metastasizing ameloblastomas, and ameloblastic carcinomas and clear cell odontogenic carcinomas showed reactivity for CD133 and Bmi-1 in most neoplastic cells.
  • The level of CD133 immunoreactivity in malignant ameloblastic tumors was significantly higher than the levels in tooth germs and ameloblastomas.
  • Some granular neoplastic cells in granular cell ameloblastomas showed ABCG2 expression.
  • [MeSH-major] ATP-Binding Cassette Transporters / analysis. Ameloblastoma / pathology. Antigens, CD / analysis. Glycoproteins / analysis. Neoplasm Proteins / analysis. Nuclear Proteins / analysis. Peptides / analysis. Proto-Oncogene Proteins / analysis. Repressor Proteins / analysis. Zinc Fingers

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  • (PMID = 19659474.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / AC133 antigen; 0 / Antigens, CD; 0 / BMI1 protein, human; 0 / Glycoproteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Peptides; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
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66. Nagatsuka H, Han PP, Tsujigiwa H, Siar CH, Gunduz M, Sugahara T, Sasaki A, Nakajima M, Naomoto Y, Nagai N: Heparanase gene and protein expression in ameloblastoma: possible role in local invasion of tumor cells. Oral Oncol; 2005 May;41(5):542-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Heparanase gene and protein expression in ameloblastoma: possible role in local invasion of tumor cells.
  • Ameloblastoma is the most common odontogenic neoplasm, particularized by its local invasiveness.
  • Heparanase is the endo-glucuronidase enzyme that specifically cleaves heparan sulfate, the important modulator of extracellular matrix, and related to invasion of tumor cells.
  • In this study, we addressed to show the gene expression and localization of heparanase in ameloblastoma.
  • Immunohistochemistry and in situ hybridization of heparanase were carried out in 23 ameloblastomas.
  • Strong expression of heparanase at both mRNA and protein levels was detected in all ameloblastomas studied.
  • Small tumor nests and budding epithelial branches showed stronger staining pattern and the stromal tissues at the immediate vicinity of the tumor nests with strong heparanase expression were loose and edematous.
  • Cystic areas and squamous metaplastic areas of the tumor showed intense staining with heparanase antibody proposing the implication of heparanase in these processes.
  • These results suggest the possible contribution of heparanase in the local invasiveness and secondary morphologic changes of ameloblastoma.
  • [MeSH-major] Ameloblastoma / enzymology. Glucuronidase / metabolism. Jaw Neoplasms / enzymology

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  • (PMID = 15878761.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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67. Chen WL, Li JS, Yang ZH, Wang JG, Zhang B: Recurrent ameloblastoma of the anterior skull base: three cases treated by radical resections. J Craniomaxillofac Surg; 2006 Oct;34(7):412-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent ameloblastoma of the anterior skull base: three cases treated by radical resections.
  • INTRODUCTION: Recurrent ameloblastomas rarely present in the anterior skull base but are, common following inadequate excision.
  • PATIENTS AND METHODS: Three patients are presented with ameloblastoma in the anterior skull base including frontotemporal fossa and pterygomaxillary fossa recurring following multiple enucleations, segmental mandibulectomy, or partial maxillectomy.
  • CONCLUSION: Ameloblastomas in these regions have a greater recurrence potential even when treated by radical dissection.
  • [MeSH-major] Ameloblastoma / surgery. Neoplasm Recurrence, Local / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 17056266.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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68. Wysluch A, Hölzle F, Maurer P: [Giant ameloblastoma of the jaw]. HNO; 2009 Nov;57(11):1193-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant ameloblastoma of the jaw].
  • [Transliterated title] Monströses Ameloblastom des Unterkiefers.
  • Ameloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts).
  • As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended.
  • [MeSH-major] Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis

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  • (PMID = 19727626.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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69. Matijević M, Leović D, Popić B, Zubcić V, Kopić V, Prlić A, Siber S, Dinjar K: The importance of thorough preoperative diagnostics of maxillary ameloblastoma: report of three cases. Coll Antropol; 2010 Dec;34(4):1445-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The importance of thorough preoperative diagnostics of maxillary ameloblastoma: report of three cases.
  • Ameloblastoma, especially maxillary, is a rare benign neoplasm of odontogenic origin.
  • Diagnosis of significant number of lesions is usually established postoperatively, because ameloblastoma, especially the unicystic form, mimics wide range of more frequent jaw lesions.
  • From January 1993 to December 2005, three cases of the maxillary ameloblastoma were surgically treated at our Department.
  • The authors present clinical, radiological and pathohistological features of the ameloblastomas in this rare localization with special attention to need of accurate preoperative diagnostics.
  • [MeSH-major] Ameloblastoma / diagnosis. Maxillary Neoplasms / diagnosis

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  • (PMID = 21874736.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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70. Wang A, Zhang B, Huang H, Zhang L, Zeng D, Tao Q, Wang J, Pan C: Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro. BMC Cancer; 2008;8:182
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro.
  • BACKGROUND: Ameloblastomas are odontogenic neoplasms characterized by local invasiveness.
  • This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas.
  • METHODS: Plasmids containing either MMP-2 siRNA or tissue inhibitor of metalloproteinase-2 (TIMP-2) cDNA were created and subsequently transfected into primary ameloblastoma cells.
  • RESULTS: Primary cultures of ameloblastoma cells expressed cytokeratin (CK) 14 and 16, and MMP-2, but only weakly expressed CK18 and vimentin.
  • Both MMP-2 siRNA and TIMP-2 overexpression inhibited MMP-2 activity and the in vitro invasiveness of ameloblastoma.
  • CONCLUSION: These results indicate that inhibition of MMP-2 activity suppresses the local invasiveness of ameloblastoma cells.
  • This mechanism may serve as a novel therapeutic target in ameloblastomas pursuant to additional research.
  • [MeSH-major] Ameloblastoma / enzymology. Jaw Neoplasms / enzymology. Matrix Metalloproteinase Inhibitors
  • [MeSH-minor] Humans. Matrix Metalloproteinase 2 / genetics. Matrix Metalloproteinase 2 / metabolism. Neoplasm Invasiveness. Plasmids / genetics. RNA, Messenger / genetics. RNA, Small Interfering / genetics. Tissue Inhibitor of Metalloproteinase-2 / biosynthesis. Tissue Inhibitor of Metalloproteinase-2 / genetics. Tissue Inhibitor of Metalloproteinase-2 / metabolism. Transfection. Tumor Cells, Cultured

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  • (PMID = 18588710.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Matrix Metalloproteinase Inhibitors; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.24 / Matrix Metalloproteinase 2
  • [Other-IDs] NLM/ PMC2443806
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71. Black CC, Addante RR, Mohila CA: Intraosseous ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Nov;110(5):585-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraosseous ameloblastoma.
  • Ameloblastomas are benign slow-growing aggressive neoplasms with a poorly understood potential for rare metastasis.
  • Microscopically, ameloblastomas are recognizable from their recapitulation of embryologic ameloblasts and stellate reticulum.
  • Treatment planning for a given tumor includes consideration of location, primary versus recurrent, size, presence of cortical perforation, and age and health of the patient.
  • [MeSH-major] Ameloblastoma / diagnosis. Jaw Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 May;111(5):536; author reply 536-8 [21306924.001]
  • (PMID = 20580278.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Sun ZJ, Wu YR, Cheng N, Zwahlen RA, Zhao YF: Desmoplastic ameloblastoma - A review. Oral Oncol; 2009 Sep;45(9):752-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic ameloblastoma - A review.
  • Among the ameloblastomas, the desmoplastic variation is rare.
  • The desmoplastic ameloblastoma (DA) is characterized by specific clinical, imaging, and histological features.
  • In conclusion, these retrospective results confirm the statement that DA is a variation among ameloblastomas.
  • DA present clinicoradiographic and histologic distinct features, when compared with "conventional ameloblastomas".
  • [MeSH-major] Ameloblastoma / epidemiology. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology

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  • (PMID = 19631576.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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73. Kumamoto H, Ooya K: Immunohistochemical detection of uPA, uPAR, PAI-1, and maspin in ameloblastic tumors. J Oral Pathol Med; 2007 Sep;36(8):488-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 45 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against uPA, uPAR, PAI-1, and maspin.
  • The levels of uPA and uPAR immunoreactivity in ameloblastic tumors were slightly higher than the levels in tooth germs, while PAI-1 reactivity in ameloblastomas tended to be lower than that in tooth germs.
  • The level of maspin immunoreactivity in ameloblastomas was significantly higher than that in tooth germs, and ameloblastic carcinoma showed decreased maspin reactivity.
  • CONCLUSION: Expression of uPA, uPAR, PAI-1, and maspin in tooth germs and ameloblastic tumors suggests that interactions among these molecules contribute to ECM degradation and cell migration during tooth development and tumor progression.
  • [MeSH-major] Ameloblastoma / pathology. Enzyme Precursors / analysis. Plasminogen Activator Inhibitor 1 / analysis. Receptors, Cell Surface / analysis. Serine Proteinase Inhibitors / analysis. Serpins / analysis. Urokinase-Type Plasminogen Activator / analysis

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  • (PMID = 17686008.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Enzyme Precursors; 0 / PLAUR protein, human; 0 / Plasminogen Activator Inhibitor 1; 0 / Receptors, Cell Surface; 0 / Receptors, Urokinase Plasminogen Activator; 0 / SERPIN-B5; 0 / Serine Proteinase Inhibitors; 0 / Serpins; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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74. Migaldi M, Sartori G, Rossi G, Cittadini A, Sgambato A: Tumor cell proliferation and microsatellite alterations in human ameloblastoma. Oral Oncol; 2008 Jan;44(1):50-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor cell proliferation and microsatellite alterations in human ameloblastoma.
  • Ameloblastoma is the most common odontogenic tumor.
  • Mutations in microsatellite sequences are a hallmark of neoplastic transformation but little is known about their role in ameloblastoma development.
  • In this study DNA was extracted from laser-microdissected samples of 24 ameloblastomas and was analyzed for the status of 22 microsatellite loci.
  • High Ki67 expression was significantly associated with a shorter disease-free survival (p=0.003 by log-rank test).
  • Alterations of at least one of the selected loci was observed in all (100%) the ameloblastomas analyzed with a mean of 4 altered microsatellites for each tumor.
  • All the other loci analyzed were altered in less than 40% of cases and some of them (D3S1312, D3S1300, IFNA, D9S164, D13S176 and TP53) did not show alterations in any of the ameloblastomas analyzed.
  • No relationship was observed between the occurrence of microsatellite alterations and other parameters, such as patients age and gender, tumor size, localization and histotype.
  • The occurrence of microsatellite alterations was more frequent in tumors displaying a high Ki67 labeling index (p=0.03) and in a univariate analysis was predictor of an increased risk of disease recurrence (p=0.039 by log-rank test).
  • These findings demonstrate that microsatellite alterations are frequent event in ameloblastomas.
  • They also suggest that evaluation of tumor cells proliferative activity and microsatellite alterations may be helpful to stratify ameloblastomas prognostically and to predict the clinical behavior of these tumors.
  • [MeSH-major] Ameloblastoma / genetics. Carcinoma, Transitional Cell / genetics. DNA, Neoplasm / genetics. Microsatellite Repeats / genetics. Odontogenic Tumors / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Cell Proliferation. Disease-Free Survival. Female. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Male. Middle Aged

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  • (PMID = 17307020.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Ki-67 Antigen
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75. Adeline VL, Dimba EA, Wakoli KA, Njiru AK, Awange DO, Onyango JF, Chindia ML: Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit. J Craniofac Surg; 2008 Nov;19(6):1589-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit.
  • This study describes the clinical and pathologic features of ameloblastomas seen in the 2 main craniofacial treatment centers in Kenya in the 10-year period between January 1995 and December 2005.
  • There was no significant difference in gender presentation of ameloblastomas, although females presented at a slightly older age.
  • Most of the ameloblastomas (n = 172; 93.5%) were located in the mandible, 11 (6.0%) were in the maxilla, and 1 (0.5%) was in the soft tissues.
  • The posterior mandible was the most commonly affected site, whereas maxillary ameloblastomas tended to occur in anterior sites.
  • One hundred fifty-three ameloblastomas (83.2%) were of the solid/multicystic subtype; 8 (5.3%) were unicystic; 1 (0.5%) was of extraosseous origin; 1 (0.5%) was desmoplastic; 9 (6.0%) were malignant, and 12 of the records had no histopathologic pattern specified.
  • [MeSH-major] Ameloblastoma / epidemiology. Jaw Neoplasms / epidemiology. Medical Audit

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  • (PMID = 19098557.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Dini LI, Mendonça R, Adamy CA, Saraiva GA: Adamantinoma of the Spine: Case Report. Neurosurgery; 2006 Aug 01;59(2):E426

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of the Spine: Case Report.

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  • (PMID = 28180646.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Souza Freitas V, Ferreira de Araújo CR, Alves PM, de Souza LB, Galvão HC, de Almeida Freitas R: Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Sep;108(3):417-24

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of matrilysins (MMP-7 and MMP-26) in ameloblastomas and adenomatoid odontogenic tumors.
  • OBJECTIVE: The aim was to evaluate the expression of matrix metalloproteinases (MMPs) 7 and 26 in ameloblastomas and adenomatoid odontogenic tumors (AOTs).
  • STUDY DESIGN: Twenty intraosseous solid ameloblastomas and 10 intraosseous AOTs were evaluated regarding immunohistochemical expression of MMP-7 and -26 in the epithelium and stroma.
  • RESULTS: There was no statistically significant difference in MMP-7 and -26 expression between the epithelium of ameloblastomas (P = .50) and AOTs (P = .90).
  • For MMP-26, stromal staining was observed in 65% of ameloblastomas and 50% of AOTs, and this difference was not statistically significant (P = .69).
  • [MeSH-major] Ameloblastoma / enzymology. Matrix Metalloproteinase 7 / analysis. Matrix Metalloproteinases, Secreted / analysis. Odontogenic Tumors / enzymology

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  • (PMID = 19570695.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.- / MMP26 protein, human; EC 3.4.24.- / Matrix Metalloproteinases, Secreted; EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
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78. Pekiner FN, Ozbayrak S, Sener BC, Olgaç V, Sinanoğlu A: Peripheral ameloblastoma: a case report. Dentomaxillofac Radiol; 2007 Mar;36(3):183-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral ameloblastoma: a case report.
  • Peripheral ameloblastoma, a rare and unusual variant of odontogenic tumour, comprises about 1% of all ameloblastomas.
  • The extraosseous location is the peculiar feature of this type of tumour, which is otherwise similar to the classical ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Neoplasms / pathology

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  • (PMID = 17463106.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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79. Alaeddini M, Etemad-Moghadam S, Baghaii F: Comparative expression of calretinin in selected odontogenic tumours: a possible relationship to histogenesis. Histopathology; 2008 Feb;52(3):299-304

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS AND RESULTS: Immunohistochemistry for calretinin was performed on 55 odontogenic tumours consisting of 20 solid ameloblastomas, five calcifying epithelial odontogenic tumours, 10 adenomatoid odontogenic tumours, 10 ameloblastic fibromas and 10 odontogenic myxomas.
  • All 20 ameloblastomas showed intense immunopositivity with a diffuse distribution pattern.
  • CONCLUSIONS: Considering that ameloblastomas, in contrast to the other studied tumours, were consistently reactive for calretinin, this protein may have a role in the pathogenesis of this aggressive neoplasm.
  • [MeSH-major] Ameloblastoma / metabolism. Biomarkers, Tumor / metabolism. Jaw Neoplasms / metabolism. Odontogenic Tumor, Squamous / metabolism. S100 Calcium Binding Protein G / metabolism

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  • (PMID = 18269580.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G
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80. Gratzinger D, Salama ME, Poh CF, Rouse RV: Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression. J Oral Pathol Med; 2008 Mar;37(3):177-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression.
  • BACKGROUND: Odontogenic neoplasms have some morphologic overlap with salivary gland neoplasms, many of which show myoepithelial differentiation.
  • In the 1980s, an ultrastructural study identified a population of myoepithelial-like cells in calcifying epithelial odontogenic tumor.
  • METHODS: We examined a series of odontogenic neoplasms, including 11 ameloblastomas, four calcifying epithelial odontogenic tumors, five glandular odontogenic cysts (GOCs), and five keratocystic odontogenic tumors with a panel of myoepithelial-associated immunohistochemical stains.
  • Calponin reactivity was at least focally present in two of four calcifying epithelial odontogenic tumors, three of five GOCs, and 10 of 11 ameloblastomas; the sole completely non-reactive ameloblastoma represents a lung metastasis.
  • One case of calcifying epithelial odontogenic tumor was focally positive for glial fibrillary acidic protein.
  • CONCLUSIONS: Ameloblastomas, GOCs, and calcifying epithelial odontogenic tumors show a distinctive immunophenotype which overlaps with that of myoepithelial-derived salivary gland neoplasms but does not provide definitive support for myoepithelial differentiation.
  • [MeSH-major] Ameloblastoma / pathology. Odontogenic Cysts / pathology. Odontogenic Tumors / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18251942.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Keratins, Type II; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / Muscle Proteins; 0 / calponin
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81. Sauk JJ, Nikitakis NG, Scheper MA: Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):68-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are we on the brink of nonsurgical treatment for ameloblastoma?
  • OBJECTIVE: Recent identification of altered molecular signaling pathways in neoplasia has begun to elucidate mechanisms of oncogenesis, differentiation, and tumor progression, and to suggest plausible nonsurgical considerations for treatment.
  • Here we review the sonic hedgehog (SHH) and PI3K/Akt/mTOR signaling pathways, their role in ameloblastoma, a locally aggressive odontogenic tumor, and evidence for consideration of therapeutic approaches that target these molecular pathways.
  • STUDY DESIGN: This is a comprehensive review of the literature regarding alterations in signaling mechanisms associated with ameloblastomas.
  • In addition, this review attempts to explore and discuss possible inhibitors to these pathways that may have utility in treating ameloblastoma.
  • RESULTS: The expression of SHH signaling molecules in ameloblastomas at the mRNA and protein levels has intimated that these molecules may play a role in cell proliferation of these tumors.
  • Immunohistochemical analysis has revealed aberrant signaling in the PI3K/Akt/mTOR pathway in ameloblastomas and appears to be a valuable tool for elucidating pathogenesis and aggressiveness, and selecting optimal therapeutics.
  • CONCLUSION: The understanding of altered pathways in ameloblastoma may soon provide nonsurgical options for the treatment of this condition.
  • [MeSH-major] Ameloblastoma / drug therapy. Signal Transduction / drug effects

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20418126.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / SHH protein, human; 0 / Transcription Factors; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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82. Yamanishi T, Ando S, Aikawa T, Kishino M, Nakano Y, Sasai K, Isomura Tanaka E, Tsuji T, Koizumi H, Iida S, Kogo M: A case of extragingival peripheral ameloblastoma in the buccal mucosa. J Oral Pathol Med; 2007 Mar;36(3):184-6
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  • [Title] A case of extragingival peripheral ameloblastoma in the buccal mucosa.
  • Peripheral ameloblastomas (PAs) of the extragingival areas are extremely rare.
  • The tumor was surgically removed by blunt dissection and there is no evidence of recurrence for 7 months.
  • We also discuss here the clinical characteristics, the origin, and the management of the tumor by reference to the relevant literature.
  • [MeSH-major] Ameloblastoma / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology

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  • (PMID = 17305641.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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83. Rauso R, Tartaro G, Gherardini G, Puglia F, Santagata M, Colella G: Recurrence of ameloblastoma in temporal area: primary treatment influences recurrence rate. J Craniofac Surg; 2010 May;21(3):887-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of ameloblastoma in temporal area: primary treatment influences recurrence rate.
  • Ameloblastomas are benign odontogenic tumors but are locally aggressive, most commonly occurring in the mandible and in the third to fifth decade of life.
  • Recurrence of ameloblastoma due to inadequate treatment is often described.
  • The authors describe a case of ameloblastoma recurrence in the temporal area and review the literature regarding recurrence and treatment.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 20485075.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Leong SC, Karkos PD, Krajacevic J, Islam R, Kent SE: Ameloblastoma of the sinonasal tract: A case report. Ear Nose Throat J; 2010 Feb;89(2):70-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma of the sinonasal tract: A case report.
  • Ameloblastomas are locally aggressive gnathic tumors with a high propensity for recurrence.
  • Presentation of an ameloblastoma exclusively in the sinonasal tract is extremely rare, with few reported cases in the literature.
  • We report a case in which the patient had complete unilateral nasal obstruction caused by an ameloblastoma.
  • The tumor was completely excised endoscopically, and at the 12-month follow-up, there was no evidence of recurrence.
  • [MeSH-major] Ameloblastoma / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 20155674.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Fregnani ER, da Cruz Perez DE, Soares FA, Alves FA: Synchronous ameloblastoma and orthokeratinized odontogenic cyst of the mandible. J Oral Pathol Med; 2006 Oct;35(9):573-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous ameloblastoma and orthokeratinized odontogenic cyst of the mandible.
  • The simultaneous occurrence of ameloblastomas with odontogenic cysts or other non-odontogenic lesions have already been described as combined lesions.
  • However, we are unaware of any report in the English literature of simultaneous occurrence of ameloblastoma and orthokeratinized odontogenic cyst (OOC) occurring as completely distinct lesions.
  • This report shows a case of synchronous ameloblastoma and OOC, located on posterior regions of the mandible, but in distinct sides.
  • [MeSH-major] Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Odontogenic Cysts / diagnosis

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  • (PMID = 16968239.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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86. dos Santos JN, De Souza VF, Azevêdo RA, Sarmento VA, Souza LB: "Hybrid" lesion of desmoplastic and conventional ameloblastoma: immunohistochemical aspects. Braz J Otorhinolaryngol; 2006 Sep-Oct;72(5):709-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Hybrid" lesion of desmoplastic and conventional ameloblastoma: immunohistochemical aspects.
  • Ameloblastoma is a benign epithelial odontogenic tumor and is the most commonly encountered odontogenic tumor in the jaws.
  • Histologically, ameloblastomas occur in different patterns, including plexiform pattern and follicular pattern.
  • "Hybrid" lesion of ameloblastoma is a tumor variant in which histologically, areas of follicular or plexiform ameloblastoma coexist with characteristic areas of ameloblastoma exhibiting pronounced stromal desmoplasia (desmoplastic ameloblastoma).
  • The purpose of this article is to present a case of "hybrid" lesion of desmoplastic ameloblastoma (AD) and conventional, and investigate extracellular matrix proteins such as tenascin, fibronectin, and type I collagen.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • [ErratumIn] Rev Bras Otorrinolaringol (Engl Ed). 2006 Nov-Dec;72(6):852
  • (PMID = 17221066.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Fibronectins; 0 / Neoplasm Proteins; 0 / Tenascin
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87. Olgac V, Koseoglu BG, Aksakalli N: Odontogenic tumours in Istanbul: 527 cases. Br J Oral Maxillofac Surg; 2006 Oct;44(5):386-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common lesions were ameloblastomas (n=133) followed by odontomas (n=109), odontogenic myxomas (n=83) and others.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Child. Child, Preschool. Female. Fibroma, Ossifying / epidemiology. Humans. Male. Middle Aged. Myxoma / epidemiology. Odontoma / epidemiology. Turkey / epidemiology

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  • (PMID = 16182417.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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88. Migaldi M, Pecorari M, Rossi G, Maiorana A, Bettelli S, Tamassia MG, De Gaetani C, Leocata P, Portolani M: Does HPV play a role in the etiopathogenesis of ameloblastoma? An immunohistochemical, in situ hybridization and polymerase chain reaction study of 18 cases using laser capture microdissection. Mod Pathol; 2005 Feb;18(2):283-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does HPV play a role in the etiopathogenesis of ameloblastoma? An immunohistochemical, in situ hybridization and polymerase chain reaction study of 18 cases using laser capture microdissection.
  • Ameloblastomas are epithelial tumors of odontogenic origin, biologically characterized by local recurrence.
  • Among different etiologic factors, HPV infection has been recently postulated to be somehow involved in ameloblastoma etiopathogenesis.
  • To address this issue, we studied 18 ameloblastomas by means of immunohistochemistry, in situ hybridization (conventional and amplified), polymerase chain reaction and nested-polymerase chain reaction analyses using laser capture microdissection in order to detect the occurrence of HPV in this setting.
  • In conclusion, our data do not support an etiopathogenetic evidence for HPV in ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology. Papillomaviridae / genetics. Papillomavirus Infections / complications

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  • (PMID = 15272281.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Oncogene Proteins, Viral
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89. Mendenhall WM, Werning JW, Fernandes R, Malyapa RS, Mendenhall NP: Ameloblastoma. Am J Clin Oncol; 2007 Dec;30(6):645-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma.
  • The purpose of this article is to review the pertinent literature and discuss the optimal treatment and outcomes for patients with ameloblastoma.
  • Ameloblastoma is an uncommon benign, locally aggressive odontogenic neoplasm that usually occurs in the vicinity of the mandibular molars or ramus.
  • Uncontrolled, ameloblastoma may cause significant morbidity and occasionally death.
  • The majority of ameloblastomas are multicystic, which are more difficult to eradicate than the unicystic and peripheral varieties.
  • In contrast, conservative procedures such as enucleation and/or curettage result in local control rates of approximately 80% and 50% for unicystic and multicystic ameloblastomas, respectively.
  • Limited experience with radiotherapy indicates that it may reduce the risk of progression and result in long-term local control in the occasional patient with incompletely resectable disease.
  • The optimal treatment for ameloblastoma is wide en bloc resection.
  • Radiotherapy may improve the likelihood of local control in the occasional patient with incompletely resectable tumor.
  • [MeSH-major] Ameloblastoma / radiotherapy. Ameloblastoma / surgery. Jaw Neoplasms / radiotherapy. Jaw Neoplasms / surgery

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  • (PMID = 18091060.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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90. Iezzi G, Piattelli A, Rubini C, Artese L, Goteri G, Fioroni M, Carinci F: CD10 expression in stromal cells of ameloblastoma variants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Feb;105(2):206-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CD10 expression in stromal cells of ameloblastoma variants.
  • OBJECTIVE: We performed an immunohistochemical study in a series of ameloblastomas with different histology to explore the existence of a correlation between CD10 immunoreactivity in peritumoral stromal cells and the type of ameloblastoma with a high risk of local recurrence.
  • STUDY DESIGN: A total of 45 ameloblastomas (18 unicystic [UA], 4 peripheral [PA], 23 solid/multicystic [SA]) were evaluated.
  • CONCLUSIONS: Our results suggest that CD10 expression might be associated with stromal invasion in ameloblastoma variants with a high risk of recurrences.
  • [MeSH-major] Ameloblastoma / classification. Ameloblastoma / immunology. Jaw Neoplasms / classification. Jaw Neoplasms / immunology. Neprilysin / biosynthesis

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  • (PMID = 17942343.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.24.11 / Neprilysin
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91. Poomsawat S, Punyasingh J, Vejchapipat P: Expression of basement membrane components in odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):666-75

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The objective was to characterize the expression of BMCs (laminins 1 and 5, collagen type IV, and fibronectin) in ameloblastomas, calcifying cystic odontogenic tumors (CCOTs), and adenomatoid odontogenic tumors (AOTs).
  • STUDY DESIGN: BMCs were analyzed in 14 ameloblastomas, 7 CCOTs, and 7 AOTs using immunohistochemistry.
  • In all tumors studied, linear deposits of all proteins were found at the epithelial-mesenchymal junction; laminin 1 was expressed in all tumor cells, regardless of cell types.
  • For AOTs, laminin 5 strongly decorated tumor cells adjacent to mineralization.
  • [MeSH-major] Ameloblastoma / pathology. Basement Membrane / pathology. Jaw Neoplasms / pathology. Odontogenic Cyst, Calcifying / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17150384.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / Collagen Type IV; 0 / Fibronectins; 0 / Laminin; 0 / kalinin; 0 / laminin 1
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92. Artes-Martínez MJ, Prieto-Rodríguez M, Navarro-Hervás M, Peñas-Pardo L, Camañas-Sanz A, Vaquero de la Hermosa MC, Vera-Sempere FJ: Ameloblastoma. Diagnosis by means of FNAB. Report of two cases. Med Oral Patol Oral Cir Bucal; 2005 May-Jul;10(3):205-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma. Diagnosis by means of FNAB. Report of two cases.
  • INTRODUCTION: Ameloblastomas are the most frequent odontogenic tumors of the maxilla.
  • We present the cytological characteristics of two cases of jugal recurrences of mandibular ameloblastomas diagnosed by FNAB, as well as their cytohistological correlation.
  • DISCUSSION: FNAB is considered to be a rapid, bloodless and reliable method for the diagnosis of ameloblastoma.
  • The cytology of these tumors reveals components of the lesion that, in general, are sufficient for the diagnosis of ameloblastoma, especially in cases of recurrence.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 15876962.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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93. Sukarawan W, Simmons D, Suggs C, Long K, Wright JT: WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviors. Am J Pathol; 2010 Jan;176(1):461-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviors.
  • In this study we demonstrated that WNT5A expression was intense in both the epithelial component of ameloblastomas, the most common epithelial odontogenic tumor, and in this tumor's likely precursor cell, the enamel epithelium located at the cervical loop of normal developing human tooth buds.
  • Additionally, when WNT5A was overexpressed in enamel epithelium cells (LS-8), the clones expressing high levels of WNT5A (S) exhibited characteristics of tumorigenic cells, including growth factor independence, loss of anchorage dependence, loss of contact inhibition, and tumor formation in immunocompromised mice.
  • Taken together, our data indicate that WNT5A signaling is important in modulating tumorigenic behaviors of enamel epithelium cells in ameloblastomas.

  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
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  • (PMID = 20008136.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / DE533921
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Proto-Oncogene Proteins; 0 / WNT5A protein, human; 0 / Wnt Proteins; 0 / Wnt5a protein, mouse
  • [Other-IDs] NLM/ PMC2797904
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94. Karacayli U, Kaya A, Aydintug YS, Gunhan O: Ploidy status of odontogenic tumors with epithelial components. Anal Quant Cytol Histol; 2010 Jun;32(3):146-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY DESIGN: Biopsy materials of cases that were diagnosed as ameloblastoma or OT with epithelial component were retrieved from archives.
  • Routine hematoxylin-eosin sections were prepared from paraffin-embedded tumor materials.
  • A monolayer cell suspension was prepared from tumor cells that were enzymatically and mechanically isolated from biopsy material.
  • There were 30 pure ameloblastomas and 30 other OTs with epithelial components.
  • CONCLUSION: The current study showed that ameloblastomas and other OTs with ameloblastic epithelial components are diploid.

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  • (PMID = 20701067.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Feulgen stain; 0 / Rosaniline Dyes
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95. Lu L, Yang J, Liu JB, Yu Q, Xu Q: Ultrasonographic evaluation of mandibular ameloblastoma: a preliminary observation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Aug;108(2):e32-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasonographic evaluation of mandibular ameloblastoma: a preliminary observation.
  • OBJECTIVE: The purpose of this study was to demonstrate ultrasonographic characteristics of mandibular ameloblastoma and assess the value of ultrasonography in diagnosis of the tumor.
  • STUDY DESIGN: Nineteen subjects with ameloblastomas in the mandibles were examined with ultrasonography.
  • Sensitivity and specificity of Doppler flow signals for prediction of active tumor proliferations were calculated.
  • RESULTS: The main sonographic features of the tumor appeared as a complex cystic mass with solid contents.
  • The sensitivity and specificity of the Doppler flow signals for prediction of active tumor proliferations were 100% and 94%, respectively.
  • CONCLUSION: Ultrasonography can be used as an effective supplementary diagnostic method for mandibular ameloblastomas.
  • CDFI of tumor vascularity could be used to predict active tumor proliferations.
  • [MeSH-major] Ameloblastoma / ultrasonography. Mandibular Neoplasms / ultrasonography

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  • (PMID = 19615642.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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96. DeVilliers P, Liu H, Suggs C, Simmons D, Daly B, Zhang S, Raubenheimer E, Larsson A, Wright T: Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor. Am J Surg Pathol; 2008 Feb;32(2):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor.
  • Ameloblastoma is a benign, locally aggressive epithelial odontogenic tumor that has the potential to become malignant and produce metastasis to distant sites such as lungs and kidneys.
  • The histologic presentation can be, in some instances, mistaken for keratocystic odontogenic tumor (KCOT) (formerly known as odontogenic keratocyst).
  • The expression of calretinin [calbindin2 (CALB2)] was investigated on both ameloblastoma and KCOT.
  • Nineteen cases of ameloblastoma and 17 cases of KCOT were stained with calretinin antiserum 18-0211 (Zymed, San Francisco, CA).
  • All cases (100%) of ameloblastoma showed positive calretinin staining, restricted to the neoplastic epithelial component and none (0%) of the 17 KCOTs showed positive calretinin staining.
  • Gene expression profiling of ameloblastomas showed CALB2 expressed in the basal cell layer of columnar cells resembling preameloblasts, in all 5 of the ameloblastomas evaluated.
  • Taken together, the results of this study strongly support calretinin as a useful immunohistochemical marker for ameloblastoma and malignant ameloblastoma and it can also be used in the differential diagnosis of KCOT.
  • [MeSH-major] Ameloblastoma / diagnosis. Biomarkers, Tumor / metabolism. Jaw Neoplasms / diagnosis. Odontogenic Cysts / diagnosis. Odontogenic Tumors / diagnosis. S100 Calcium Binding Protein G / metabolism

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  • (PMID = 18223328.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE016079
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / S100 Calcium Binding Protein G
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97. Kumamoto H, Ooya K: Detection of mitochondria-mediated apoptosis signaling molecules in ameloblastomas. J Oral Pathol Med; 2005 Oct;34(9):565-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of mitochondria-mediated apoptosis signaling molecules in ameloblastomas.
  • BACKGROUND: To investigate the roles of the apoptosis signaling pathway mediated by mitochondria in oncogenesis and cytodifferentiation of odontogenic tumors, expression of pathway signaling molecules was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of 12 tooth germs, 41 benign ameloblastomas, and five malignant ameloblastomas were examined by reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of cytochrome c, apoptotic protease-activating factor-1 (APAF-1), caspase-9, and apoptosis-inducing factor (AIF).
  • Immunoreactivity for cytochrome c in tooth germs was slightly weaker than that in benign and malignant ameloblastomas.
  • Keratinizing cells in acanthomatous ameloblastomas and granular cells in granular cell ameloblastomas showed a decrease or loss of immunoreactivity for these mitochondria-mediated apoptosis signaling molecules.
  • CONCLUSION: Expression of cytochrome c, APAF-1, caspase-9, and AIF in tooth germs and ameloblastomas suggests that the mitochondria-mediated apoptotic pathway has a role in apoptotic cell death of normal and neoplastic odontogenic epithelium.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis / physiology. Intracellular Signaling Peptides and Proteins / analysis. Mitochondria / physiology. Signal Transduction / physiology

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  • (PMID = 16138896.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / AIFM1 protein, human; 0 / APAF1 protein, human; 0 / Apoptosis Inducing Factor; 0 / Apoptotic Protease-Activating Factor 1; 0 / Flavoproteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Proteins; 9007-43-6 / Cytochromes c; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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98. Gomes CC, Oliveira Cda S, Castro WH, de Lacerda JC, Gomez RS: Clonal nature of odontogenic tumours. J Oral Pathol Med; 2009 Apr;38(4):397-400

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Fresh samples of seven ameloblastomas, two odontogenic mixomas, two adenomatoid odontogenic tumour, one calcifying odontogenic cyst, one calcifying epithelial odontogenic tumour (CEOT) and six odontogenic keratocyst (OKC) of female patients were included in this study.

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  • (PMID = 19298504.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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99. Gong Y, Wang L, Wang H, Li T, Chen X: The expression of NF-kappaB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC. Oral Oncol; 2009 Jun;45(6):515-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • According to the WHO classification of head and neck tumors in 2005, COC has been divided into calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC).
  • The specimens of 26 COCs and 10 classic ameloblastomas (as control group) were examined by immunohistochemistry using anti-NF-kappaB p65, anti-Ki-67 and anti-MMP-9 antibodies and by in situ hybridization(ISH)using anti-MMP-9 mRNA probes.
  • Immunohistochemical reactivity for NF-kappaB was mainly detected in the cytoplasm of tumor cells, and nuclear reactivity was only seen in few tumor cells in COC and classic ameloblastomas.
  • The expression of Ki-67 in GCOC was significantly higher than those in CCOT (p<0.001), DGCT and ameloblastoma (p<0.005).
  • In COCs and ameloblastomas, expression of MMP-9 mRNA and protein was detected in tumor cells as well as in stromal cells.
  • [MeSH-minor] Ameloblastoma / metabolism. China. Humans. In Situ Hybridization / methods. Ki-67 Antigen / metabolism

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  • (PMID = 18723387.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / NF-kappa B; 0 / Neoplasm Proteins; EC 3.4.24.35 / Matrix Metalloproteinase 9
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100. Jeblaoui Y, Ben Neji N, Haddad S, Ouertatani L, Hchicha S: [Algorithm for the treatment of ameloblastoma in Tunisia]. Rev Stomatol Chir Maxillofac; 2007 Nov;108(5):419-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Algorithm for the treatment of ameloblastoma in Tunisia].
  • INTRODUCTION: Ameloblastoma is a benign but locally aggressive and infiltrative odontogenic neoplasm.
  • Numerous methods of treatment have been proposed but the latest studies showed that a radical treatment is the recommended protocol for the surgical management of ameloblastomas.
  • The purpose of this study was to review the clinical features and surgical treatment of ameloblastomas treated in our department and to propose an algorithm for the treatment adapted to our country.
  • Data with respect to the patients' ages, sex, tumor locations, and surgical treatment history, as well as radiographic findings and number of recurrences, was analyzed.
  • Sixty-two percent of ameloblastomas were located in the mandibular angle.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Oral Surgical Procedures / methods

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  • (PMID = 17572460.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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