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1. Sachs SA: Surgical excision with peripheral ostectomy: A definitive, yet conservative, approach to the surgical management of ameloblastoma. J Oral Maxillofac Surg; 2006 Mar;64(3):476-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical excision with peripheral ostectomy: A definitive, yet conservative, approach to the surgical management of ameloblastoma.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Osteotomy / methods

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  • (PMID = 16487812.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 16
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2. Bologna-Molina R, Mosqueda-Taylor A, Lopez-Corella E, de Almeida OP, Carrasco-Daza D, Farfán-Morales JE, Molina-Frechero N, Damián-Matsumura P: Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma. Pathol Int; 2009 Apr;59(4):229-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma.
  • The aims of the present study were to examine whether the pattern of syndecan-1 expression correlates with cellular proliferation index in desmoplastic ameloblastomas (DA), peripheral ameloblastomas (PA) and ameloblastic carcinomas (AC), and to compare with that previously reported for solid (SA) and unicystic (UA) variants of ameloblastoma.
  • Immunohistochemistry was performed for syndecan-1 and Ki-67 in seven ameloblastomas (four DA and three PA) and three AC.
  • Syndecan-1 expression correlated inversely with Ki-67 proliferative index: the expression was lower in both types of ameloblastomas (1.5% in DA and 6.4% in PA) than in AC (41.2%; P < 0.05).
  • These data suggest that DA differ from the other types of intraosseous ameloblastomas but more studies are necessary to better understand the role of this protein as a marker in the biological behavior of the epithelial odontogenic neoplasms.
  • [MeSH-major] Ameloblastoma / pathology. Carcinoma / pathology. Jaw Neoplasms / pathology. Ki-67 Antigen / biosynthesis. Syndecan-1 / biosynthesis

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  • (PMID = 19351365.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Syndecan-1
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3. Abu El-Naaj I, Emodi O, Peled M: Metachronous ameloblastomas in the maxilla and mandible: report of a case. J Craniomaxillofac Surg; 2005 Oct;33(5):349-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous ameloblastomas in the maxilla and mandible: report of a case.
  • Ameloblastoma is a locally aggressive tumour of odontogenic origin, with an unknown aetiology.
  • Metachronous ameloblastoma in the maxilla and the mandible is rare.
  • In this report, a case of a 63 year-old man is described with a solid ameloblastoma in the posterior part of the upper jaw.
  • Both ameloblastomas were of the solid type but differed in their histological patterns.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 16129610.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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4. de Vicente JC, Torre-Iturraspe A, Gutiérrez AM, Lequerica-Fernández P: Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions. Med Oral Patol Oral Cir Bucal; 2010 Sep;15(5):e709-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The present study was undertaken to compare the pattern of expression of EGFR, cyclin D1, Ki-67, p-53 and carcinoembryonic antigen (CEA) in the epithelial lining of odontogenic keratocysts, dentigerous cysts, radicular cysts and ameloblastomas.
  • METHODS: four micrometers, formalin-fixed, paraffin-embedded tissue sections from 11 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts and 10 ameloblastomas were immunohistochemically studied.
  • RESULTS: There were statistically significant differences between cyclin D1 expression in odontogenic keratocysts and radicular cysts (p=0.001) and ameloblastomas (p=0.04).
  • In dentigerous cysts this mean was of 17%, of 15.5% in RC and of 7.8 in ameloblastomas.


5. Bello IO, Soini Y, Slootweg PJ, Salo T: Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth. J Oral Pathol Med; 2007 Jan;36(1):48-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth.
  • BACKGROUND: To analyze the distribution pattern of claudins 1, 4, 5, 7 and occludin in benign and malignant ameloblastomas and developing human teeth.
  • METHODS: Paraffin-embedded tissue specimens of 25 benign and four malignant ameloblastomas and two developing human teeth were examined immunohistochemically using antibodies against claudins 1, 4, 5, 7 and occludin.
  • RESULTS: In ameloblastomas strongest expression was seen for claudins 1 and 7 while claudin 4 was expressed less frequently.
  • There were no evident differences in the expression of claudins or occludin neither between different histologic subtypes of ameloblastomas nor between benign or malignant cases.
  • The strongest expression for claudins was present in the central stellatum reticulum-like cells surrounding the microcysts and in the areas with squamous differentiation of the ameloblastomas.
  • Claudin 5 was preferentially expressed only in vessels, and occludin staining ranged from negative to weak in ameloblastomas and teeth germs.
  • [MeSH-major] Ameloblastoma / pathology. Membrane Proteins / analysis. Odontogenesis / physiology. Tight Junctions / pathology. Tooth Germ / pathology

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  • (PMID = 17181742.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / CLDN4 protein, human; 0 / CLDN5 protein, human; 0 / CLDN7 protein, human; 0 / Claudin-1; 0 / Claudin-4; 0 / Claudin-5; 0 / Claudins; 0 / Membrane Proteins; 0 / OCLN protein, human; 0 / Occludin
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6. Oral pathology quiz #58. Case number 4. Ameloblastoma. J N J Dent Assoc; 2008;79(1):15, 23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral pathology quiz #58. Case number 4. Ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 18561424.001).
  • [ISSN] 0093-7347
  • [Journal-full-title] Journal of the New Jersey Dental Association
  • [ISO-abbreviation] J N J Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Gomes CC, Duarte AP, Diniz MG, Gomez RS: Review article: Current concepts of ameloblastoma pathogenesis. J Oral Pathol Med; 2010 Sep;39(8):585-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Review article: Current concepts of ameloblastoma pathogenesis.
  • Ameloblastoma is a locally destructive and invasive tumour that can recur despite adequate surgical removal.
  • Molecular studies have offered interesting findings regarding ameloblastoma pathogenesis.
  • It is clear from the literature reviewed that translational studies are necessary to identify prognostic markers of ameloblastoma behaviour and to establish new diagnostic tools to the differential diagnosis of unicystic from multicystic ameloblastoma.
  • [MeSH-major] Ameloblastoma / etiology
  • [MeSH-minor] Apoptosis / genetics. Cell Proliferation. Clone Cells. Dental Enamel Proteins / genetics. Genes, Tumor Suppressor / physiology. Humans. Matrix Metalloproteinases / physiology. Osteoclasts / physiology. Signal Transduction / genetics

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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20618608.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / AMBN protein, human; 0 / Dental Enamel Proteins; EC 3.4.24.- / Matrix Metalloproteinases
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8. Sauk JJ, Nikitakis NG, Scheper MA: Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):68-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are we on the brink of nonsurgical treatment for ameloblastoma?
  • OBJECTIVE: Recent identification of altered molecular signaling pathways in neoplasia has begun to elucidate mechanisms of oncogenesis, differentiation, and tumor progression, and to suggest plausible nonsurgical considerations for treatment.
  • Here we review the sonic hedgehog (SHH) and PI3K/Akt/mTOR signaling pathways, their role in ameloblastoma, a locally aggressive odontogenic tumor, and evidence for consideration of therapeutic approaches that target these molecular pathways.
  • STUDY DESIGN: This is a comprehensive review of the literature regarding alterations in signaling mechanisms associated with ameloblastomas.
  • In addition, this review attempts to explore and discuss possible inhibitors to these pathways that may have utility in treating ameloblastoma.
  • RESULTS: The expression of SHH signaling molecules in ameloblastomas at the mRNA and protein levels has intimated that these molecules may play a role in cell proliferation of these tumors.
  • Immunohistochemical analysis has revealed aberrant signaling in the PI3K/Akt/mTOR pathway in ameloblastomas and appears to be a valuable tool for elucidating pathogenesis and aggressiveness, and selecting optimal therapeutics.
  • CONCLUSION: The understanding of altered pathways in ameloblastoma may soon provide nonsurgical options for the treatment of this condition.
  • [MeSH-major] Ameloblastoma / drug therapy. Signal Transduction / drug effects

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20418126.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / SHH protein, human; 0 / Transcription Factors; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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9. Sharma S, Kumar D, Vashistha A, Bihani U, Trehan M: Recurrent unicystic ameloblastoma of the infratemporal and temporal fossa. Int J Clin Pediatr Dent; 2009 Jan;2(1):33-8
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  • [Title] Recurrent unicystic ameloblastoma of the infratemporal and temporal fossa.
  • The ameloblastoma has been described as benign but locally invasive; benign and locally invasive with strong tendency to recur; and locally malignant.

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  • (PMID = 25206097.001).
  • [ISSN] 0974-7052
  • [Journal-full-title] International journal of clinical pediatric dentistry
  • [ISO-abbreviation] Int J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4086554
  • [Keywords] NOTNLM ; Unicystic / ameloblastoma / infratemporal temporal.
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10. Carlson ER, Marx RE: The ameloblastoma: primary, curative surgical management. J Oral Maxillofac Surg; 2006 Mar;64(3):484-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The ameloblastoma: primary, curative surgical management.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Maxillary Neoplasms / surgery. Neoplasm Recurrence, Local / prevention & control. Osteotomy / methods

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  • (PMID = 16487813.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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11. Ide F, Mishima K, Miyazaki Y, Saito I, Kusama K: Peripheral ameloblastoma in-situ: an evidential fact of surface epithelium origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Nov;108(5):763-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral ameloblastoma in-situ: an evidential fact of surface epithelium origin.
  • The proposed origin from the adult gingival epithelium for peripheral ameloblastoma is difficult to prove and still remains unresolved.
  • In addition to the morphologic overlap, early ameloblastoma epithelia shared antigenic properties with tumor cells of representative control examples of peripheral ameloblastoma.
  • This is the first description of an in situ lesion of peripheral ameloblastoma, to our knowledge, and its multifocal ameloblastoma changes can be accepted as a direct proof of origin from the surface epithelium.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Neoplasms / pathology

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  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May;109(5):655-6; author reply 656-7 [20416531.001]
  • (PMID = 19748296.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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12. Paikkatt VJ, Sreedharan S, Kannan VP: Unicystic ameloblastoma of the maxilla: a case report. J Indian Soc Pedod Prev Dent; 2007 Apr-Jun;25(2):106-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unicystic ameloblastoma of the maxilla: a case report.
  • Unicystic ameloblastoma is believed to be less aggressive and responds more favorably to conservative surgery than the solid or multicystic ameloblastomas.
  • This report is a rare case of unicystic ameloblastoma of the maxilla that was treated by enucleation under suspicion of a radicular cyst related to a dens in dente.
  • With this report, the authors illustrate the importance and complexity of a differential diagnosis of lesions with a cystic aspect in the anterior region of the maxilla, among them - inflammatory radicular cysts, odontogenic keratocysts, adenomatoid odontogenic and unicystic ameloblastoma.
  • Relevant diagnostic problems and choice of treatment of unicystic ameloblastoma are presented along with a review of the literature.
  • [MeSH-major] Ameloblastoma / diagnosis. Maxillary Neoplasms / diagnosis

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  • (PMID = 17660648.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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13. Siar CH, Nakano K, Han PP, Nagatsuka H, Ng KH, Kawakami T: Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma. J Oral Pathol Med; 2010 Aug 1;39(7):552-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma.
  • The ameloblastoma, a benign odontogenic epithelial neoplasm, histologically recapitulates the enamel organ at bell stage.
  • Notch has been detected in the plexiform and follicular ameloblastoma.
  • Its activity in the desmoplastic ameloblastoma is unknown.
  • METHOD: Notch1-4 and their ligands (Jagged1, Jagged2 and Delta1) were examined immunohistochemically in 10 cases of desmoplastic ameloblastoma.
  • RESULTS: Ameloblastoma tumor epithelium demonstrated positive expression for Notch1 (n = 5/10), Notch3 (n = 8/10), Notch4 (n = 10/10), Jagged1 (n = 6/10) and Delta1 (n = 5/10), but no reactivity for Notch2 (n = 10/10) and Jagged2 (10/10).
  • CONCLUSIONS: These findings suggest that Notch receptors and their ligands may play differing roles during the development of the desmoplastic ameloblastoma with Notch4 probably playing a greater role in the acquisition of tissue-specific cellular characteristics in the desmoplastic ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Receptors, Notch / analysis

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  • (PMID = 20337864.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / JAG2 protein, human; 0 / Ligands; 0 / Membrane Proteins; 0 / NOTCH1 protein, human; 0 / NOTCH2 protein, human; 0 / NOTCH3 protein, human; 0 / NOTCH4 protein, human; 0 / Proto-Oncogene Proteins; 0 / Receptor, Notch1; 0 / Receptor, Notch2; 0 / Receptors, Notch; 0 / delta protein; 134324-36-0 / Serrate proteins
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14. Carnelio S, Vij H: Expression of tenascin and nucleolar organizer region in ameloblastoma and ameloblastic fibroma. J Oral Pathol Med; 2010 Mar;39(3):223-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of tenascin and nucleolar organizer region in ameloblastoma and ameloblastic fibroma.
  • BACKGROUND: The aim of this study was to assess the expression, distribution and comparison of tenascin, a glycoprotein of the extracellular matrix in ameloblastoma and ameloblastic fibroma, both odontogenic neoplasms with diverse biological behavior and to understand the proliferative activity by using the morphometric analysis.
  • METHODS: Paraffin embedded tissue from 25 cases of odontogenic tumors i.e., ameloblastoma (n = 15) and ameloblastic fibroma (n = 10) were used.
  • Morphometric analysis of nucleolar organizer regions (NORs) from ameloblastoma and ameloblastic fibroma was carried out by silver staining.
  • RESULTS: A heterogeneous expression of tenascin was found in ameloblastoma which was mainly localized at the epithelial-mesenchymal interface and a patchy distribution was observed in the stroma (80%), while strong positivity was observed in the stroma and at the basement membrane zone of ameloblastic fibroma (100%).
  • argyrophilic nucleolar organizer regions (AgNORs) revealed higher mean counts in ameloblastoma (3.093 +/- 0.902) when compared with those of ameloblastic fibroma (1.553 +/- 0.250).
  • Ameloblastoma presented more than two NORs (two to five) per nucleus in majority of the cells, while ameloblastic fibroma exhibited only one NORs per nucleus.
  • CONCLUSIONS: Expression of tenascin in these neoplasms suggest that it could play a role in epithelial- mesenchymal interaction, while AgNORs reveal that ameloblastomas are more aggressive when compared with ameloblastic fibromas.
  • [MeSH-major] Ameloblastoma / pathology. Nucleolus Organizer Region / ultrastructure. Odontogenic Tumors / pathology. Tenascin / analysis

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  • (PMID = 19943856.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Tenascin
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15. Kelly JM, Belding BA, Schaefer AK: Acanthomatous ameloblastoma in dogs treated with intralesional bleomycin. Vet Comp Oncol; 2010 Jun;8(2):81-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acanthomatous ameloblastoma in dogs treated with intralesional bleomycin.
  • Acanthomatous ameloblastoma (AA) is a benign gingival tumour that often invades bone.
  • [MeSH-major] Ameloblastoma / veterinary. Antibiotics, Antineoplastic / therapeutic use. Bleomycin / therapeutic use. Dog Diseases / drug therapy. Gingival Neoplasms / veterinary

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  • (PMID = 20579320.001).
  • [ISSN] 1476-5829
  • [Journal-full-title] Veterinary and comparative oncology
  • [ISO-abbreviation] Vet Comp Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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16. González-Alva P, Kikuchi K, Miyazaki Y, Okamoto E, Oku Y, Tsuchiya H, Noguchi Y, Sakashita H, Ide F, Kusama K: Expression of heparanase: a possible role in invasiveness and aggressive clinical behavior of ameloblastomas. J Oral Sci; 2010 Mar;52(1):39-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of heparanase: a possible role in invasiveness and aggressive clinical behavior of ameloblastomas.
  • In the present study, we carried out an immunohistochemical investigation of heparanase to extend and confirm present knowledge regarding its expression in ameloblastomas (AMs), which are characterized by locally aggressive behavior.
  • Small tumor nests and budding epithelial branches showed a stronger staining pattern.
  • However, an enhanced positive immunoreaction was present specifically near osseous tissue and adjacent to the invasive front of tumor nests.
  • The enzyme may facilitate the function of HS-binding growth factors that elicit an angiogenic response and favor osteoclastogenesis in AM.
  • [MeSH-major] Ameloblastoma / enzymology. Glucuronidase / biosynthesis. Jaw Neoplasms / enzymology

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  • (PMID = 20339231.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.2.1.- / heparanase; EC 3.2.1.31 / Glucuronidase
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17. Requena L, Kutzner H: Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants. J Cutan Pathol; 2006 Sep;33 Suppl 2:42-5
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  • RESULTS: One lesion showed abundant intercellular mucin, closely resembling to adamantinoma, and therefore was named adamantinoid seborrheic keratosis.
  • [MeSH-major] Adamantinoma / pathology. Keratinocytes / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972954.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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18. Adebiyi KE, Ugboko VI, Omoniyi-Esan GO, Ndukwe KC, Oginni FO: Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med; 2006;2:42
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  • [Title] Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population.
  • BACKGROUND: This study was carried out to establish the relative incidence and provide clinico-pathologic information on the various histological types of ameloblastoma seen at the Obafemi Awolowo University Teaching Hospital complex, Ile-Ife in order to provide a baseline data which will be of significance to the pathologist and clinician.
  • METHODS: Clinico-pathologic data on a total of 77 histologically diagnosed cases of ameloblastoma archieved at the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife over a 15 year period were obtained and analysed descriptively.
  • RESULTS: Follicular ameloblastoma was the most common histological type (50 cases, 64.9%), followed by plexiform ameloblastoma (10 cases, 13.0%).
  • 4 (5.2%) cases of desmoplastic and 3 (3.9%) cases of acanthomatous ameloblastoma were seen while the basal cell variant accounted for 2 (2.6%) cases.
  • Ameloblastoma occurred over an age range of 11 to 70 years with a peak age incidence in the 3rd decade.
  • CONCLUSION: This study provides a baseline data on variants of ameloblastoma as obtained in a suburban Nigerian population.
  • Since variants of ameloblastoma differ in biologic behaviour, the data collected in this study provides clinicopathologic information which is of significance to the pathologist and clinician.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology. Suburban Population

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  • (PMID = 17125498.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1675998
  • [General-notes] NLM/ Original DateCompleted: 20070724
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19. Arotiba GT, Ladeinde AL, Arotiba JT, Ajike SO, Ugboko VI, Ajayi OF: Ameloblastoma in Nigerian children and adolescents: a review of 79 cases. J Oral Maxillofac Surg; 2005 Jun;63(6):747-51
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  • [Title] Ameloblastoma in Nigerian children and adolescents: a review of 79 cases.
  • PURPOSE: To descriptively review the clinicopathologic presentation and management of ameloblastoma in Nigerian children and adolescents and compare this with previous reports in the literature.
  • RESULTS: Out of a total of 360 patients with a diagnosis of ameloblastoma, 79 were under 20 years of age at presentation (21.9%).
  • The most common morphologic type was solid multicystic ameloblastoma (82.3%).
  • In most patients (57.3%), the symphysial region of the mandible was involved by the tumor.
  • CONCLUSION: Ameloblastoma in Nigerian children and adolescents exhibit some peculiar clinical features: these include the predominance of males, and of the solid multicystic morphologic type.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 15944968.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Fujii H, Honoki K, Enomoto Y, Kasai T, Kido A, Amano I, Kumamoto M, Morishita T, Mii Y, Nonomura A, Takakura Y: Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report. Virchows Arch; 2006 Nov;449(5):579-84
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  • [Title] Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report.
  • Recent studies have advocated the genotypic and phenotypic delineation of a novel Ewing's sarcoma histologic variant showing epithelial features defined as "adamantinoma-like Ewing's sarcoma".
  • The diagnosis of the lesion was confirmed as Ewing's sarcoma by the presence of the EWS-FLI1 fusion transcript, and could be defined as the so-called "adamantinoma-like Ewing's sarcoma".
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. Sarcoma, Ewing / pathology

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  • (PMID = 17016721.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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21. Baughman R: Testing your diagnostic skills. Case no. 1: pleomorphic adenoma. Case no. 2: desmoplastic ameloblastoma. Todays FDA; 2005 Mar;17(3):20, 22-3
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  • [Title] Testing your diagnostic skills. Case no. 1: pleomorphic adenoma. Case no. 2: desmoplastic ameloblastoma.
  • [MeSH-major] Adenoma, Pleomorphic / diagnosis. Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis. Salivary Gland Neoplasms / diagnosis

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  • (PMID = 19244687.001).
  • [ISSN] 1048-5317
  • [Journal-full-title] Today's FDA : official monthly journal of the Florida Dental Association
  • [ISO-abbreviation] Todays FDA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Chuang FH, Wang WC, Shen YH, Lin LM, Chen YK: Occurrence of ameloblastoma in a patient with nasopharyngeal carcinoma after treatment by irradiation. Spec Care Dentist; 2010 Jan-Feb;30(1):27-8
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  • [Title] Occurrence of ameloblastoma in a patient with nasopharyngeal carcinoma after treatment by irradiation.
  • Ameloblastoma is the most common clinically significant epithelial odontogenic tumor, and is considered a benign but locally aggressive tumor of the craniofacial region.
  • We present the case history of a 46-year-old male patient who had a nasopharyngeal carcinoma (NPC) treated by irradiation, which was complicated by the occurrence of an ameloblastoma.
  • Following a review of the English language literature, this case history was identified as being the first report, to our knowledge, of the occurrence of ameloblastoma in a patient who had been irradiated for an NPC.
  • [MeSH-major] Ameloblastoma / diagnosis. Carcinoma / radiotherapy. Mandibular Neoplasms / diagnosis. Nasopharyngeal Neoplasms / radiotherapy. Neoplasms, Second Primary / diagnosis

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  • (PMID = 20051072.001).
  • [ISSN] 1754-4505
  • [Journal-full-title] Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
  • [ISO-abbreviation] Spec Care Dentist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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23. Zhong Y, Wang L, Chen XM: [Expression of p-p38MARK, uPA and Ki-67 in epithelial odontogenic tumour]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):535-9
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  • METHODS: the specimens of ameloblastoma (AB), keratocystic odontogenic tumour (KCOT), calcifying epithelial odontogenic tumor (CEOT), adenomatoid odontogenic tumour (AOT), calcifying cystic odontogenic tumour (CCOT) and 5 tooth germs were examined immunohistochemically for the expression of p-p38MAPK, uPA and Ki-67.
  • Furthermore, there was a statistically significant difference in the expression of p-p38MAPK, uPA and Ki-67 between epithelial odontogenic tumor group and tooth germ group (P < 0.05).
  • [MeSH-minor] Ameloblastoma. Epithelial Cells. Humans. Phosphorylation. Tooth Germ

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  • (PMID = 21122446.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator; Adenoameloblastoma; Calcifying Epithelial Odontogenic Tumor
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24. Ghandhi D, Ayoub AF, Pogrel MA, MacDonald G, Brocklebank LM, Moos KF: Ameloblastoma: a surgeon's dilemma. J Oral Maxillofac Surg; 2006 Jul;64(7):1010-4
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  • [Title] Ameloblastoma: a surgeon's dilemma.
  • PURPOSE: To investigate whether there were any significant differences in the mode of presentation, treatment, and outcome of patients presenting with a primary diagnosis of ameloblastoma in Glasgow, Scotland and San Francisco, CA.
  • MATERIALS AND METHODS: All cases of ameloblastoma seen in both institutions between January 1, 1980 and December 31, 1999 were included in this study.
  • Primary care by conservative treatment led to a recurrence in approximately 80% of cases and this included cases of unicystic ameloblastoma.
  • CONCLUSION: The mode of presentation, diagnosis, and management of the ameloblastoma was remarkably similar in Glasgow and San Francisco.
  • The recurrence rate following local enucleation and curettage was unacceptably high, and this included the cases of unicystic ameloblastoma, which should be treated more aggressively than has been recommended in the past.
  • [MeSH-major] Ameloblastoma / epidemiology. Mandibular Neoplasms. Maxillary Neoplasms. Neoplasm Recurrence, Local

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  • (PMID = 16781332.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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25. Kpemissi E, Amana B, Tchandana K: [Mandibular tumours: epidemology, diagnostic and therapeutic aspects concerning 91 cases]. Mali Med; 2009;24(3):47-52
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  • The benign forms were the most frequent (72.88%), the ameloblastoma in particular.
  • CONCLUSION: The mandibular tumours were relatively frequent and predominated by the ameloblastoma.

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  • (PMID = 20093221.001).
  • [ISSN] 1993-0836
  • [Journal-full-title] Le Mali médical
  • [ISO-abbreviation] Mali Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mali
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26. Van Rijn R, Bras J, Schaap G, van den Berg H, Maas M: Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol; 2006 Oct;36(10):1068-74
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  • [Title] Adamantinoma in childhood: report of six cases and review of the literature.
  • BACKGROUND: Adamantinoma is a rare slow-growing malignant bone tumour.
  • MATERIALS AND METHODS: The database of the Working Group on Paediatric Oncology, Academic Medical Centre/Emma Children's Hospital Amsterdam, was searched for cases of adamantinoma.
  • Additionally a literature study was performed to identify cases of adamantinoma in childhood.
  • RESULTS: We identified six local cases of adamantinoma of the long bones, two boys (age 3 and 8 years) and four girls (mean age 8.8 years, range 3.0-14.0 years).
  • On follow-up (mean 6.1 years, range 1.6-12.0 years) all children remained disease-free.
  • CONCLUSION: Although the incidence of adamantinoma is low, it is important to recognize this rare bone tumour, since in the early stages of the disease adequate treatment will result in an excellent prognosis.
  • [MeSH-major] Adamantinoma / diagnosis

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  • (PMID = 16906392.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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27. Singhaniya SB, Barpande SR, Bhavthankar JD: Dentinogenic ghost cell tumor. J Oral Maxillofac Pathol; 2009 Jul;13(2):97-100
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  • [Title] Dentinogenic ghost cell tumor.
  • Dentinogenic ghost cell tumor (DGCT) is a rare tumorous form of calcifying odontogenic cyst and only a small number of cases have been described.
  • It is a locally invasive neoplasm that is characterized by ameloblastoma-like epithelial islands, ghost cells and dentinoid.
  • The present report describes a case of a 21-year-old male with a tumor in the posterior region of the mandible, showing features of DGCT.

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  • (PMID = 21887011.001).
  • [ISSN] 0973-029X
  • [Journal-full-title] Journal of oral and maxillofacial pathology : JOMFP
  • [ISO-abbreviation] J Oral Maxillofac Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3162870
  • [Keywords] NOTNLM ; Dentinoid / dentinogenic ghost cell tumor / ghost cell
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28. Park YK, Ryu KN, Han CS: Synchronous intracortical adamantinomas with keratin cyst formation. Skeletal Radiol; 2006 Mar;35(3):185-9
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  • Adamantinoma of the long bones is a rare primary bone tumor of uncertain embryogenesis.
  • This keratin cyst formation is quite an unusual finding in classic adamantinoma.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Fibula / pathology. Keratins / analysis. Magnetic Resonance Imaging. Tibia / pathology

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  • (PMID = 16217667.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins
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29. Niu CH, Li TJ: [Mutation and polymorphism of the ameloblastin gene in ameloblastomas]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Nov;41(11):678-81
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  • [Title] [Mutation and polymorphism of the ameloblastin gene in ameloblastomas].
  • OBJECTIVE: To investigate the presence of mutation or polymorphism of ameloblastin (AMBN) gene in ameloblastomas.
  • METHODS: Genomic DNA was extracted from frozen tissues of 10 ameloblastomas and one malignant ameloblastoma.
  • Restriction fragment length polymorphism (RFLP) analysis was used to further determine the nature of the changes in AMBN detected in tumor samples in comparison to 100 control samples.
  • RESULTS: AMBN mutation was not identified in all 11 tumor samples.
  • CONCLUSIONS: AMBN gene mutation is not identified in the present group of ameloblastomas.
  • The frequently detected AMBN alterations in ameloblastomas are polymorphisms, which appear to be unrelated to the occurrence of ameloblastomas.
  • [MeSH-major] Ameloblastoma / genetics. Dental Enamel Proteins / genetics. Jaw Neoplasms / genetics. Polymorphism, Genetic

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  • (PMID = 17331365.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AMBN protein, human; 0 / Dental Enamel Proteins
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30. Yamada S, Matsuo T, Yanamoto S, Suyama K, Mizuno A, Fujita S: Ameloblastoma. Pathol Int; 2005 Feb;55(2):92-4
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  • [Title] Ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology

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  • (PMID = 15693856.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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31. Habesoglu TE, Habesoglu M, Surmeli M, Uresin T, Egeli E: Unilateral sinonasal symptoms. J Craniofac Surg; 2010 Nov;21(6):2019-22
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  • There were 12 cases of antrochoanal polyp, 14 of nasal polyposis, 8 of chronic rhinosinusitis, 7 of concha bullosa, 4 of retention cyst in maxillary sinus, 2 of mucocele, 3 of oroantral originated cyst, and 13 cases of benign or malign neoplastic diseases, some of which were extremely rare cases such as pleomorphic adenoma, ameloblastoma, schwannoma, myxoma, and non-Hodgkin lymphoma.
  • Nasal discharge was more common in inflammatory than neoplastic disease.
  • However, epistaxis was more common in neoplastic disease.
  • A careful history, examination, and radiographic studies can often determine the responsible disease process.
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adolescent. Adult. Aged. Ameloblastoma / diagnosis. Diagnosis, Differential. Endoscopy. Epistaxis / diagnosis. Humans. Lymphoma, Non-Hodgkin / diagnosis. Maxillary Sinus / pathology. Middle Aged. Mucocele / diagnosis. Myxoma / diagnosis. Nasal Obstruction / diagnosis. Nasal Polyps / diagnosis. Nasopharyngeal Diseases / diagnosis. Nasopharynx / pathology. Neurilemmoma / diagnosis. Nonodontogenic Cysts / diagnosis. Nose Diseases / diagnosis. Retrospective Studies. Rhinitis / diagnosis. Sinusitis / diagnosis. Tomography, X-Ray Computed. Turbinates / pathology. Young Adult

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  • (PMID = 21119491.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Bianchi B, Copelli C, Ferrari S, Ferri A, Sesenna E: Free flaps: outcomes and complications in head and neck reconstructions. J Craniomaxillofac Surg; 2009 Dec;37(8):438-42
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  • They included 303 reconstructions after cancer surgery (80.6%), 28 secondary reconstructions (7.4%), 32 transfers for facial paralysis (8.5%) and 13 reconstructions for other pathology (3.5%) such as osteonecrosis and ameloblastoma.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Ameloblastoma / surgery. Child. Diabetes Complications. Facial Paralysis / surgery. Female. Graft Survival. Head and Neck Neoplasms / surgery. Humans. Male. Middle Aged. Osteonecrosis / surgery. Postoperative Complications. Radiotherapy, Adjuvant / adverse effects. Risk Factors. Smoking / adverse effects. Surgical Wound Dehiscence / etiology. Thrombosis / etiology. Tissue and Organ Harvesting / adverse effects. Tissue and Organ Harvesting / methods. Treatment Outcome. Young Adult

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  • (PMID = 19553132.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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33. Chandrasekar CR, Mohammed R, Rafalla AA, Grimer RJ: Adamantinoma of the calcaneum--a case report. Foot (Edinb); 2009 Mar;19(1):58-61
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  • [Title] Adamantinoma of the calcaneum--a case report.
  • Adamantinoma is rare, representing less than 1% of all primary malignant bone tumours.
  • Adamantinoma commonly occurs in the tibia.
  • Adamantinoma of the foot is extremely rare.
  • To our knowledge adamantinoma of the calcaneum has not been previously reported in the literature.
  • We report the case of a male patient, aged 33 years, who was treated for adamantinoma of the calcaneum and followed for 16 years highlighting the difficulty in diagnosis and management of this rare tumor occurring at a rare site.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Calcaneus / pathology

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  • (PMID = 20307451.001).
  • [ISSN] 1532-2963
  • [Journal-full-title] Foot (Edinburgh, Scotland)
  • [ISO-abbreviation] Foot (Edinb)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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34. Zhong M, Liu JD, Wang J, Liu J, Li L, Hou L, Zhang B: [Expression and significance of hTERT, c-fos and c-jun in ameloblastoma]. Shanghai Kou Qiang Yi Xue; 2006 Oct;15(5):461-5
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  • [Title] [Expression and significance of hTERT, c-fos and c-jun in ameloblastoma].
  • PURPOSE: To investigate the expression of c-fos, c-jun and hTERT mRNA in human ameloblastoma (AB) and to determine their clinicobiological significance.
  • METHODS: In situ hybridization was performed to examine the expression of c-fos, c-jun and hTERT mRNA in AB and 7 cases of normal oral mucosa (NOM), 16 cases of keratocystic odontogenic tumor (KCOT) were selected as controls.
  • [MeSH-major] Ameloblastoma / metabolism. Jaw Neoplasms / metabolism. RNA, Messenger / metabolism

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  • (PMID = 17348214.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Messenger
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35. Hayes MI, Prince SE: Peripheral ameloblastoma: a case report. Dent Update; 2006 Dec;33(10):624-5
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  • [Title] Peripheral ameloblastoma: a case report.
  • Peripheral ameloblastoma is an uncommon pathological variant of the more usual intraosseous central ameloblastoma.
  • There was no evidence of bony involvement on radiographs but it was revealed histologically to be a peripheral ameloblastoma.
  • [MeSH-major] Ameloblastoma / diagnosis. Gingival Neoplasms / diagnosis

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  • (PMID = 17209538.001).
  • [ISSN] 0305-5000
  • [Journal-full-title] Dental update
  • [ISO-abbreviation] Dent Update
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Ozlugedik S, Ozcan M, Basturk O, Deren O, Kaptanoglu E, Adanali G, Unal A: Ameloblastic carcinoma arising from anterior skull base. Skull Base; 2005 Nov;15(4):269-72; discussion 273
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  • Ameloblastic carcinoma (AC) is an aggressive malignant epithelial odontogenic tumor.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.

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  • [Cites] Head Neck. 1998 Oct;20(7):654-9 [9744469.001]
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  • (PMID = 16648889.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1380266
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37. Sandra F, Hendarmin L, Nakao Y, Nakamura N, Nakamura S: TRAIL cleaves caspase-8, -9 and -3 of AM-1 cells: a possible pathway for TRAIL to induce apoptosis in ameloblastoma. Tumour Biol; 2005 Sep-Oct;26(5):258-64
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  • [Title] TRAIL cleaves caspase-8, -9 and -3 of AM-1 cells: a possible pathway for TRAIL to induce apoptosis in ameloblastoma.
  • Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL/Apo-2L), a potent ligand in inducing apoptosis, has recently emerged as a novel anticancer agent based on its ability to induce apoptosis in tumor cells, while exhibiting no toxicity in most normal cells.
  • Since no potent apoptosis-inducing factor has been found yet in ameloblastoma, the present study was conducted.
  • In the present study, expressions of TRAIL receptors, death receptor 4 (DR4) and DR5, were detected in all ameloblastoma tissues by immunohistochemistry as well as in AM-1 cells by immunofluorescence.
  • By applying TRAIL in AM-1 cells, ameloblastoma cell line, for 24 h, we found that TRAIL cleaved caspase-8, -9 and -3, and lowered mitochondrial membrane potential (Deltapsim), and markedly induced apoptosis in AM-1 cells (46%).
  • These results suggested that TRAIL is a potent apoptosis-inducing ligand in ameloblastoma.
  • [MeSH-major] Apoptosis / genetics. Caspases / metabolism. Membrane Glycoproteins / physiology. Mouth Neoplasms / genetics. Mouth Neoplasms / physiopathology. Tumor Necrosis Factor-alpha / physiology

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 16110259.001).
  • [ISSN] 1010-4283
  • [Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
  • [ISO-abbreviation] Tumour Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Ligands; 0 / Membrane Glycoproteins; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFSF10 protein, human; 0 / Tumor Necrosis Factor-alpha; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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38. Adeline VL, Dimba EA, Wakoli KA, Njiru AK, Awange DO, Onyango JF, Chindia ML: Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit. J Craniofac Surg; 2008 Nov;19(6):1589-93
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  • [Title] Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit.
  • This study describes the clinical and pathologic features of ameloblastomas seen in the 2 main craniofacial treatment centers in Kenya in the 10-year period between January 1995 and December 2005.
  • There was no significant difference in gender presentation of ameloblastomas, although females presented at a slightly older age.
  • Most of the ameloblastomas (n = 172; 93.5%) were located in the mandible, 11 (6.0%) were in the maxilla, and 1 (0.5%) was in the soft tissues.
  • The posterior mandible was the most commonly affected site, whereas maxillary ameloblastomas tended to occur in anterior sites.
  • One hundred fifty-three ameloblastomas (83.2%) were of the solid/multicystic subtype; 8 (5.3%) were unicystic; 1 (0.5%) was of extraosseous origin; 1 (0.5%) was desmoplastic; 9 (6.0%) were malignant, and 12 of the records had no histopathologic pattern specified.
  • [MeSH-major] Ameloblastoma / epidemiology. Jaw Neoplasms / epidemiology. Medical Audit

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  • (PMID = 19098557.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Oral pathology quiz #52. Case number 3. Ameloblastoma. J N J Dent Assoc; 2006;77(3):16, 44
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  • [Title] Oral pathology quiz #52. Case number 3. Ameloblastoma.
  • [MeSH-major] Ameloblastoma / radiography. Mandibular Neoplasms / radiography

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  • (PMID = 17039612.001).
  • [ISSN] 0093-7347
  • [Journal-full-title] Journal of the New Jersey Dental Association
  • [ISO-abbreviation] J N J Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Tanahashi J, Daa T, Yada N, Kashima K, Kondoh Y, Yokoyama S: Mutational analysis of Wnt signaling molecules in ameloblastoma with aberrant nuclear expression of beta-catenin. J Oral Pathol Med; 2008 Oct;37(9):565-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mutational analysis of Wnt signaling molecules in ameloblastoma with aberrant nuclear expression of beta-catenin.
  • BACKGROUND: To clarify the genetic background of ameloblastoma, expression of beta-catenin, and mutational status of genes involved in Wnt signaling pathway were investigated.
  • METHODS: We analyzed beta-catenin and cyclin D1 in 18 cases of ameloblastoma by immunohistochemical staining, and searched for mutations in CTNNB1 (gene for beta-catenin), APC, AXIN1, and AXIN2 by polymerase chain reaction (PCR) and direct sequencing method.
  • CONCLUSION: Mutations in CTNNB1, APC, AXIN1, and AXIN2 are not implicated in nuclear accumulation of beta-catenin, and that the expression of cyclin D1 is accelerated independently of beta-catenin in ameloblastomas.
  • [MeSH-major] Ameloblastoma / metabolism. Cell Nucleus / metabolism. Cyclin D1 / metabolism. Jaw Neoplasms / metabolism. Wnt Proteins / genetics. beta Catenin / metabolism

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  • (PMID = 18284543.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Wnt Proteins; 0 / beta Catenin; 136601-57-5 / Cyclin D1
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41. Daneshbod Y, Khademi B, Moemeni B, Seif I, Daneshbod K: Preoperative washing cytology in the diagnosis of maxillary sinus lesions. Acta Cytol; 2010 Mar-Apr;54(2):148-58
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  • STUDY DESIGN: Over a 4-year period, 96 p tients with clinical or radiologic suspicion of a malignant maxillary sinus tumor either confined to the maxillary complex or extending to the nasal cavity underwent preoperative cytologic evaluation by sinus puncture and local washing or nasal washing.
  • Borderline lesions included hemangiopericytoma (4) and ameloblastoma (3).

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  • (PMID = 20391970.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Scheper MA, Chaisuparat R, Nikitakis NG, Sauk JJ: Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas. Oral Dis; 2008 Sep;14(6):561-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas.
  • OBJECTIVES: Recently, an allelic loss of phosphatase and tensin homologue (PTEN) was shown to occur in ameloblastomas.
  • METHODS: Thirty ameloblastomas and five dental follicles were studied, looking at the immunohistochemical expression of total PTEN and AKT, as well as their phosphorylated (p) active forms, and the downstream effector and indicator of mTOR activity p70 ribosomal-subunit-6 kinase (pS6K).
  • RESULTS: Total PTEN was absent in 33.3% of ameloblastomas, while its stabilized, phosphorylated(ser380 / thr382 / thr383) form was absent in 83.3% of tumors.
  • In contrast, AKT was expressed in 83.3% of ameloblastomas, showing high expression of the p-thr(308)AKT and p-ser(473) AKT forms in 93.3% and 56.6% of cases, respectively.
  • Further, the mTOR activated pS6K(ser240 / 244) was detected in 86.7% of ameloblastomas, while ERK was overexpressed in 70.0% of the cases.
  • CONCLUSION: Immunohistochemical analysis of aberrant signaling in the PI3K/AKT/mTOR pathway in ameloblastomas may represent a valuable tool for elucidating pathogenesis, aggressiveness and selecting optimal therapeutics.
  • [MeSH-major] Ameloblastoma / pathology. PTEN Phosphohydrolase / analysis. Phosphatidylinositol 3-Kinases / analysis. Protein Kinases / analysis. Proto-Oncogene Proteins c-akt / analysis

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  • (PMID = 18826385.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.- / Protein Kinases; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa; EC 2.7.11.1 / ribosomal protein S6 kinase, 70kD, polypeptide 2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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43. Gao L, Li TJ: [In vitro study on bone resorption of odontogenic cysts and ameloblastomas]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 May;40(3):233-6
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  • [Title] [In vitro study on bone resorption of odontogenic cysts and ameloblastomas].
  • OBJECTIVE: To investigate the effect of bone resorption by odontogenic cysts and ameloblastomas in vitro.
  • METHODS: Fragments of odontogenic cysts (14 odontogenic keratocysts, 6 inflamed odontogenic keratocysts, 5 dentigerous cysts) and ameloblastomas (n = 7) were incubated in vitro for 24 h.
  • The supernatant of odontogenic cysts and ameloblastomas was measured for the bone resorption related factors such as IL-6, TNF-alpha, PGE(2), bone Gla-containing protein (BGP) and calcitonin (CT) by a radioimmunoassay system.
  • The inflamed odontogenic keratocyst group had a significantly higher calcium concentration than odontogenic keratocyst and ameloblastoma groups (P < 0.05).
  • IL-6 concentration in the inflamed and non-inflamed odontogenic keratocyst groups were significantly higher than that of ameloblastoma group (P < 0.05).
  • [MeSH-major] Ameloblastoma / physiopathology. Bone Resorption. Odontogenic Cysts / physiopathology

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  • (PMID = 15938889.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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44. Namba Y, Kimata Y, Koshima I, Sugihara S, Sato T: Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report. Acta Med Okayama; 2006 Aug;60(4):233-6
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  • [Title] Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report.
  • We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Fibula / surgery. Skin Transplantation. Surgical Flaps. Tibia / surgery

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  • (PMID = 16943861.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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45. Zhang ZH, Lu YC, Meng QF, Wu PH: [CT diagnosis of various subtypes of ameloblastoma in the maxillomandibular region]. Ai Zheng; 2006 Oct;25(10):1266-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [CT diagnosis of various subtypes of ameloblastoma in the maxillomandibular region].
  • BACKGROUND & OBJECTIVE: Based on biological behavior and histopathologic characteristics, ameloblastomas in the maxillomandibular region can be divided into several subtypes with different prognosis.
  • This study was to explore the clinical and CT imaging features of solid or multicystic ameloblastoma (SMA), unicystic ameloblastoma (UA), and malignant ameloblastoma (MA), and thus to improve the CT diagnostic accuracy for these diseases.
  • METHODS: Clinical and CT features of 25 histologically proven ameloblastomas in the maxillomandibular region, including 14 SMAs, 6 UAs, and 5 MAs were analyzed retrospectively.
  • Combined analysis of CT images and clinical data is helpful in differentiating these 3 subtypes of ameloblastoma.
  • [MeSH-major] Ameloblastoma / radiography. Mandibular Neoplasms / radiography. Maxillary Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 17059773.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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46. Raitz R, Correa L, Fenyo-Pereira M: Radiographic interpretation of unilocular radiolucent mandibular lesions. Acta Odontol Latinoam; 2009;22(2):123-8
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  • A total of 24 panoramic radiographs were selected exhibiting the following lesions: ameloblastoma, keratocystic odontogenic tumor, dentigerous cyst and simple bone cyst.

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  • (PMID = 19839489.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Argentina
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47. Zabolinejad N, Hiradfar M, Anvari K, Razavi AS: Ameloblastic fibrosarcoma of the maxillary sinus in an infant: a case report with long-term follow-up. J Pediatr Surg; 2008 Feb;43(2):e5-8
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  • The tumor was composed of odontogenic epithelium, resembling that of ameloblastoma, and a mesenchymal part exhibiting features of fibrosarcoma.
  • Although AFS has occurred in a wide age range, this is the first report of this tumor in infancy with long-term follow-up.
  • [MeSH-major] Ameloblastoma / diagnosis. Fibrosarcoma / diagnosis. Maxillary Sinus Neoplasms / diagnosis

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  • (PMID = 18280269.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Torres-Lagares D, Infante-Cossío P, Hernández-Guisado JM, Gutiérrez-Pérez JL: Mandibular ameloblastoma. A review of the literature and presentation of six cases. Med Oral Patol Oral Cir Bucal; 2005 May-Jul;10(3):231-8
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  • [Title] Mandibular ameloblastoma. A review of the literature and presentation of six cases.
  • Ameloblastoma is a benign odontogenic tumour of epithelial origin without induction in the connective tissue.
  • Articles have recently been published with the purpose of providing updated knowledge and therapeutic approaches to ameloblastoma.
  • We present six cases of patients with localised mandibular ameloblastoma who were treated during the last seven years.
  • We present data on clinical appearance, histological characteristics, and therapeutic approach that was used, which included excision of the lesion, perilesional drilling of the bone, or block resection, according to the type of ameloblastoma.
  • The aim of this paper is to review the concepts relating to ameloblastoma that have been published recently and to assess their influence on the clinical attitude taken when facing this pathology, using our experience with ameloblastoma as a starting point to illustrate this discussion.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 15876966.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 33
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49. Bologna-Molina R, Mosqueda-Taylor A, de Almeida-Oslei P, Toral-Rizo V, Martínez-Mata G: Peripheral desmoplastic ameloblastoma: histopathological and immunohistochemical profile of a case. Med Oral Patol Oral Cir Bucal; 2010 Nov;15(6):e846-9
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  • [Title] Peripheral desmoplastic ameloblastoma: histopathological and immunohistochemical profile of a case.
  • In this study we present a rare case of peripheral desmoplastic ameloblastoma and discuss its clinical features, histopathology, and immunohistochemical profile.
  • Histopathological findings were similar to the two previously reported cases of this tumor.
  • Reports of new cases of peripheral desmoplastic ameloblastoma are necessary for a better understanding of the origin and behavior of this particular subtype of ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 20526273.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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50. Marucci G, Betts CM, Michal M, Foschini MP: Peripheral ameloblastoma with Merkel cells. Virchows Arch; 2005 Feb;446(2):204-5
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  • [Title] Peripheral ameloblastoma with Merkel cells.
  • [MeSH-major] Ameloblastoma / pathology. Merkel Cells / pathology. Mouth Neoplasms / pathology

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  • [Cites] Histopathology. 1977 Jan;1(1):21-30 [615831.001]
  • [Cites] Virchows Arch. 1998 Oct;433(4):291-6 [9808429.001]
  • [Cites] Arch Oral Biol. 2000 Oct;45(10):879-87 [10973561.001]
  • [Cites] Oral Oncol. 2001 Jan;37(1):17-27 [11120479.001]
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  • (PMID = 15735981.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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51. Akrish S, Buchner A, Shoshani Y, Vered M, Dayan D: Ameloblastic carcinoma: report of a new case, literature review, and comparison to ameloblastoma. J Oral Maxillofac Surg; 2007 Apr;65(4):777-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastic carcinoma: report of a new case, literature review, and comparison to ameloblastoma.
  • [MeSH-minor] Aged, 80 and over. Ameloblastoma / diagnosis. Diagnosis, Differential. Humans. Male

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  • (PMID = 17368379.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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52. Mosca RC, Marques MM, Barbosa SC, Marcucci M, Oliveira JX, Lascala CA: Odontoameloblastoma: report of two cases. Indian J Dent Res; 2009 Apr-Jun;20(2):230-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Odontoameloblastoma (OA) is a very rare mixed odontogenic neoplasm, characterized by the simultaneous occurrence of an ameloblastoma and a compound or complex odontoma in the same tumor mass.
  • In this study, we present two cases of OA, which we hope will contribute to the awareness and knowledge of surgeons regarding the existence of this odontogenic tumor so that patients having it may be treated and followed-up properly.
  • [MeSH-major] Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis. Maxillary Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Odontoma / diagnosis

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  • (PMID = 19553728.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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53. Kawabata T, Takahashi K, Sugai M, Murashima-Suginami A, Ando S, Shimizu A, Kosugi S, Sato T, Nishida M, Murakami K, Iizuka T: Polymorphisms in PTCH1 affect the risk of ameloblastoma. J Dent Res; 2005 Sep;84(9):812-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polymorphisms in PTCH1 affect the risk of ameloblastoma.
  • Ameloblastoma is the most common odontogenic tumor, but the genetic nature of the changes in the tumor cells has been unclear.
  • Both CTNNB1 and PTCH1 are important in tooth development and are expressed in ameloblastoma.
  • The aim of this study was to investigate whether genetic alterations of CTNNB1 and PTCH1 are present in ameloblastoma.
  • We investigated 14 cases of ameloblastoma.
  • The polymorphisms found in the ameloblastoma patients were further examined in a subsequent case-control study.
  • We found a CTNNB1 mutation in one case of plexiform-type ameloblastoma.
  • The proportion of CGG8 alleles was significantly higher in the ameloblastoma group.
  • The results of this study indicate a possible relationship between the CGG8 allele in PTCH1 and the risk for ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Receptors, Cell Surface / genetics

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  • (PMID = 16109989.001).
  • [ISSN] 0022-0345
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / PTCH protein, human; 0 / Patched Receptors; 0 / Patched-1 Receptor; 0 / Receptors, Cell Surface; 0 / Trans-Activators; 0 / beta Catenin
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54. Gilijamse M, Leemans CR, Winters HA, Schulten EA, van der Waal I: Metastasizing ameloblastoma. Int J Oral Maxillofac Surg; 2007 May;36(5):462-4
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  • [Title] Metastasizing ameloblastoma.
  • Ameloblastomas are locally invasive tumours of odontogenic origin with a high propensity for local recurrence.
  • Here is presented a case of a 26-year-old woman with a recurrent ameloblastoma of the mandible and a metastatic lymph node in the homolateral neck.
  • [MeSH-major] Ameloblastoma / secondary. Lymphatic Metastasis / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17275258.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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55. Hirota M, Aoki S, Kawabe R, Fujita K: Desmoplastic ameloblastoma featuring basal cell ameloblastoma: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Feb;99(2):160-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic ameloblastoma featuring basal cell ameloblastoma: a case report.
  • The desmoplastic ameloblastoma is a histological variant of ameloblastoma.
  • The neoplastic epithelial islands seen in desmoplastic ameloblastoma are small and ameloblastic cells are rare.
  • Basal cell ameloblastoma is also a rare variant of ameloblastoma, in which the tumor is composed of more primitive cells and has even fewer features of peripheral palisading.
  • This report describes the case of a 17-year-old female with an ameloblastoma in the right anterior maxilla.
  • A partial maxillectomy for tumor resection was performed under general anesthesia.
  • Histologically, ameloblastic tumor cells were seen with dense collagenous stroma and the tumor cells showed primarily basal cell variants of ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 15660085.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-34-5 / Collagen
  • [Number-of-references] 24
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56. Gong YL, Wang L, Chen XM, Wang HK, Wang XH: [Expression of nuclear factor-kappaB, Ki-67 and matrix metalloproteinase-9 in calcifying odontogenic cyst]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Oct;41(10):627-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Twenty-six cases of COC were classified into calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) based on the WHO classification of odontogenic tumors in 2005.
  • The specimens of COC and 10 classic ameloblastoma (AB) were examined immunohistochemically to determine the expression of NF-kappaB p65, Ki-67 and MMP-9.
  • RESULTS: NF-kappaB was mainly detected in the cytoplasm of most tumor cells, but was only detected in the nucleus of few tumor cells (rate of nuclear staining < 1%).
  • MMP-9 was detected both in tumor cells and stromal cells.

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  • (PMID = 17129456.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / NF-kappa B; EC 3.4.24.35 / Matrix Metalloproteinase 9
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57. Chukwuneke FN, Ajuzieogu O, Chukwuka A, Okwuowulu T, Nnodi P, Oji C: Surgical challenges in the treatment of advanced cases of ameloblastoma in the developing world: The authors' experience. Int J Oral Maxillofac Surg; 2010 Feb;39(2):150-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical challenges in the treatment of advanced cases of ameloblastoma in the developing world: The authors' experience.
  • Total mandibulectomy was carried out in 32 patients with extensive oro-facial lesions histologically diagnosed as ameloblastoma in four specialist centres in south-eastern Nigeria from January 2001 to December 2006.
  • This article highlights the challenges in the surgical management of advanced cases of ameloblastoma in the developing world and proposes a middle ground for professional interactions and exchange programmes among oral and maxillofacial surgeons across the world to assist poorer countries in the management of these advanced cases of oro-facial tumours.
  • [MeSH-major] Ameloblastoma / surgery. Developing Countries. Mandibular Neoplasms / surgery

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  • [Copyright] Copyright 2009 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20047817.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Denmark
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58. Kumamoto H, Ooya K: Immunohistochemical detection of uPA, uPAR, PAI-1, and maspin in ameloblastic tumors. J Oral Pathol Med; 2007 Sep;36(8):488-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 45 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against uPA, uPAR, PAI-1, and maspin.
  • The levels of uPA and uPAR immunoreactivity in ameloblastic tumors were slightly higher than the levels in tooth germs, while PAI-1 reactivity in ameloblastomas tended to be lower than that in tooth germs.
  • The level of maspin immunoreactivity in ameloblastomas was significantly higher than that in tooth germs, and ameloblastic carcinoma showed decreased maspin reactivity.
  • CONCLUSION: Expression of uPA, uPAR, PAI-1, and maspin in tooth germs and ameloblastic tumors suggests that interactions among these molecules contribute to ECM degradation and cell migration during tooth development and tumor progression.
  • [MeSH-major] Ameloblastoma / pathology. Enzyme Precursors / analysis. Plasminogen Activator Inhibitor 1 / analysis. Receptors, Cell Surface / analysis. Serine Proteinase Inhibitors / analysis. Serpins / analysis. Urokinase-Type Plasminogen Activator / analysis

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  • (PMID = 17686008.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Enzyme Precursors; 0 / PLAUR protein, human; 0 / Plasminogen Activator Inhibitor 1; 0 / Receptors, Cell Surface; 0 / Receptors, Urokinase Plasminogen Activator; 0 / SERPIN-B5; 0 / Serine Proteinase Inhibitors; 0 / Serpins; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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59. Auluck A, Shetty S, Desai R, Mupparapu M: Recurrent ameloblastoma of the infratemporal fossa: diagnostic implications and a review of the literature. Dentomaxillofac Radiol; 2007 Oct;36(7):416-9
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  • [Title] Recurrent ameloblastoma of the infratemporal fossa: diagnostic implications and a review of the literature.
  • It is unusual for odontogenic tumours such as ameloblastoma to occur in the infratemporal fossa.
  • A case of recurrent ameloblastoma in the infratemporal fossa region arising from an extension of the lesion from the site of previous occurrence in the right mandibular body is reported.
  • [MeSH-major] Ameloblastoma / secondary. Mandibular Neoplasms / surgery. Skull Neoplasms / secondary. Temporal Bone / radiography

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  • (PMID = 17881602.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 15
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60. De-Domingo B, González F, Lorenzo P: [Gorlin syndrome (nevoid basal cell carcinoma syndrome)]. Arch Soc Esp Oftalmol; 2008 May;83(5):321-4
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  • CLINICAL CASE: A 77 year-old male patient with Parkinson's disease and senile dementia had many facial basal cell carcinomas and an ectropion of the left eye.
  • When he experienced respiratory difficulty he was diagnosed to have an ameloblastoma in left nostril requiring surgery.

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  • (PMID = 18464182.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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61. Gleason BC, Liegl-Atzwanger B, Kozakewich HP, Connolly S, Gebhardt MC, Fletcher JA, Perez-Atayde AR: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol; 2008 Mar;32(3):363-76
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  • [Title] Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal.
  • Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals.
  • Although OFD has typical histopathologic features, areas resembling OFD have often been noted at the periphery of otherwise classic adamantinomas, and some have suggested that OFD may be either a precursor to or a regressive phase of adamantinoma.
  • The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma.
  • Patients with OFD were generally younger than those with adamantinoma.
  • Osteoblastic and osteoclastic activity was more prominent in OFD than in OFD-like adamantinoma.
  • In addition to the inconspicuous small clusters of epithelial cells in OFD-like adamantinoma, isolated keratin-positive cells with a unique ultrastructural hybrid fibroblastic-epithelial phenotype were found in the stroma of all OFD and OFD-like adamantinomas.
  • Fluorescence in situ hybridization analysis revealed trisomies 7, 8, and/or 12 in the spindle cell stroma of OFD, OFD-like, and classic adamantinoma, supporting a neoplastic origin of OFD and a common histogenesis for all 3 lesions.
  • Of the 11 OFD patients with follow-up (median, 4.5 y), all 3 who underwent incisional biopsy had persistent, nonprogressive disease and 2 of 8 who underwent curettage or wide excision had recurrence; none developed adamantinoma.
  • All 6 adamantinoma patients with follow-up (3 classic and 3 OFD-like) were treated with wide excision.
  • One with classic adamantinoma died of pulmonary metastases 9 years after presentation; the other 5 were free of disease with a median follow-up of 12 years.
  • None of the classic adamantinomas evolved into OFD-like adamantinoma or OFD.
  • Although the histopathology, immunohistochemistry, ultrastructure, and cytogenetics indicate that these lesions are closely related, our data and the literature suggest that only classic adamantinoma has malignant potential.
  • OFD, OFD-like adamantinoma, and classic adamantinoma appear to show a progressive complexity of cytogenetic aberrations, perhaps indicative of a multistep neoplastic transformation.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Fibrous Dysplasia of Bone / pathology

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  • (PMID = 18300815.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Rizzardi C, Leocata P, Ventura L, Zweyer M, Brollo A, Schneider M, Melato M: Apoptosis-related factors (TRAIL, DR4, DR5, DcR1, DcR2, apoptotic cells) and proliferative activity in ameloblastomas. Anticancer Res; 2009 Apr;29(4):1137-42
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  • [Title] Apoptosis-related factors (TRAIL, DR4, DR5, DcR1, DcR2, apoptotic cells) and proliferative activity in ameloblastomas.
  • BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a recently identified death factor that acts as a potent apoptosis inducer in ameloblastomas.
  • MATERIALS AND METHODS: The expression of TRAIL and its receptors (TRAIL-R), and the location of apoptotic cells were evaluated in 15 cases of ameloblastoma using immunohistochemistry and an in situ DNA nick-end labeling method.
  • The proliferative activity of ameloblastomas was analyzed by determining the Ki-67 labeling index.
  • RESULTS: TRAIL and TRAIL-R were diffusely expressed in ameloblastomas, without clear correlation with the location of apoptotic cells.
  • Apoptosis and proliferation were opposite in the peripheral and central components of the ameloblastomas.
  • In some ameloblastoma variants, apoptosis and proliferation seemed to modify in the same direction.
  • CONCLUSION: TRAIL and its receptors might be involved in neoplastic transformation of odontogenic epithelium and might suggest some intrinsic regulation of neoplastic cell proliferation and death in ameloblastomas, thus explaining their slow growth and inability to metastasize.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis. Receptors, TNF-Related Apoptosis-Inducing Ligand / metabolism. Receptors, Tumor Necrosis Factor / metabolism. Receptors, Tumor Necrosis Factor, Member 10c / metabolism. TNF-Related Apoptosis-Inducing Ligand / metabolism

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  • (PMID = 19414356.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / Receptors, Tumor Necrosis Factor; 0 / Receptors, Tumor Necrosis Factor, Member 10c; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFRSF10A protein, human; 0 / TNFSF10 protein, human
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63. Shamim T, Ipe Varghese V, Shameena PM, Sudha S: Clear cell ameloblastoma in a young child--an enigma in diagnosis. Indian J Pathol Microbiol; 2007 Apr;50(2):362-4
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  • [Title] Clear cell ameloblastoma in a young child--an enigma in diagnosis.
  • Clear cell ameloblastoma is an odontogenic tumour with aggressive behaviour usually noticed in 6th decade of life.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17883074.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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64. Chen WL, Ouyang KX, Li HG, Huang ZQ, Li JS, Wang JG: Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma. J Craniofac Surg; 2009 Jan;20(1):171-5; discussion 176-7
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  • [Title] Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma.
  • The purposes of this study were to determine the correlation between the expression of inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) in ameloblastoma and to examine the relationships of this expression to angiogenesis and the clinical and biological behaviors of the tumor.
  • Immunohistochemical staining with streptavidin peroxidase was used to analyze iNOS and VEGF expression, and CD34 was used to evaluate microvascular density (MVD) in 35 ameloblastomas (24 primary tumors and 11 recurrences) and 5 malignant ameloblastomas.
  • On relational analysis, positive and VEGF expression and MVD counts increased in this order: OKCs, primary ameloblastoma, recurrent ameloblastoma, and malignant ameloblastoma.
  • Differences between the ameloblastomas and OKCs were significant (P < 0.05).
  • Among ameloblastomas, MVD counts increased with increasing expression of iNOS and VEGF (P < 0.05), and iNOS expression and VEGF expression were positively correlated (r = 0.66, P < 0.05).
  • Inducible nitric oxide synthase expression and VEGF expression may be closely related to the angiogenesis and invasive biological behavior of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Neovascularization, Pathologic / pathology. Nitric Oxide Synthase Type II / analysis. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 19165019.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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66. Reichart PA, Jundt G: [Benign epithelial odontogenic tumors]. Pathologe; 2008 May;29(3):175-6, 178-88
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  • [Transliterated title] Benigne epitheliale odontogene Tumoren.
  • The group of benign epithelial odontogenic tumors consists of the four member types of the ameloblastoma family (solid/multicystic, extraosseous/peripheral, desmoplastic, unicystic), squamous odontogenic tumors, calcifying odontogenic tumors, adenomatoid odontogenic tumors, and keratocystic odontogenic tumors, the former "keratocysts" that were recently reclassified by the World Health Organization and are now regarded as tumors.
  • The latter are by far the most frequent tumors in this group, followed by solid/multicystic ameloblastoma.
  • [MeSH-major] Jaw Neoplasms / pathology. Odontogenic Cyst, Calcifying / pathology. Odontogenic Tumor, Squamous / pathology. Odontoma / pathology
  • [MeSH-minor] Ameloblastoma / classification. Ameloblastoma / pathology. Ameloblastoma / surgery. Cementoma / classification. Cementoma / pathology. Cementoma / surgery. Diagnosis, Differential. Humans. Jaw / pathology. Jaw / surgery. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 18389236.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] Adenoameloblastoma
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67. Ide F, Obara K, Mishima K, Saito I, Horie N, Shimoyama T, Kusama K: Peripheral odontogenic tumor: a clinicopathologic study of 30 cases. General features and hamartomatous lesions. J Oral Pathol Med; 2005 Oct;34(9):552-7
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  • [Title] Peripheral odontogenic tumor: a clinicopathologic study of 30 cases. General features and hamartomatous lesions.
  • Odontogenic fibroma and ameloblastoma were by far the most common.
  • Of POH, two purely epithelial lesions showed multiple strands of basaloid rests [odontogenic gingival epithelial hamartoma (OGEH)] and a conglomerate of polyhedral epithelium, ghost cells and concentric calcifications (calcifying epithelial odontogenic tumor-like hamartoma), respectively.
  • OGEH and peripheral squamous odontogenic tumor (PSOT) deserve to be a related entity.
  • [MeSH-minor] Ameloblastoma / pathology. Calcinosis / pathology. Child. Cysts / pathology. Ectoderm / pathology. Enamel Organ / pathology. Epithelium / pathology. Female. Humans. Male. Mesoderm / pathology. Middle Aged. Odontoma / pathology

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  • (PMID = 16138894.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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68. Ohtsuru M: Expression of parathyroid hormone-related protein in ameloblastomas. Tokai J Exp Clin Med; 2005 Dec;30(4):233-9
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  • [Title] Expression of parathyroid hormone-related protein in ameloblastomas.
  • Parathyroid hormone-related protein (PTHrP) was first discovered as a causative protein for hypercalcemia, which is often seen in the malignant tumor.
  • The present study, therefore, sought to clarify the expression of PTHrP, parathyroid hormone (PTH) and PTH1R in ameloblastoma, using RT-PCR (N = 8), immunohistochemistry (N = 23) and ELISA (N = 11) techniques.
  • Expression of PTHrP was also seen in all of the 23 cases in ameloblastoma by immunohistochemistry.
  • PTH1R was observed on osteoblasts in bone around the tumor but no expression was observed on ameloblastoma cells in tumor parenchyma by immunohistochemistry.
  • PTH was not detected in ameloblastoma by RT-PCR, immunohistochemistory as well as ELISA.
  • In addition, hypercalcemia and increase of serum PTHrP level was observed in one case of 8 ameloblastomas.
  • It was suggested that PTHrP level may be associated with local bone infiltration and hypercalcemia in ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Ameloblastoma / metabolism. Jaw Neoplasms / genetics. Jaw Neoplasms / metabolism. Parathyroid Hormone-Related Protein / genetics. Parathyroid Hormone-Related Protein / metabolism

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  • (PMID = 16482944.001).
  • [ISSN] 0385-0005
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / PTH1R protein, human; 0 / Parathyroid Hormone; 0 / Parathyroid Hormone-Related Protein; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptor, Parathyroid Hormone, Type 1; 0 / Receptors, Parathyroid Hormone; SY7Q814VUP / Calcium
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69. Papaioannou M, Manika K, Tsaoussis B, Cheva A, Sichletidis L, Kioumis J: Ameloblastoma of the mandible with pulmonary metastases 45 years after initial diagnosis. Respirology; 2009 Nov;14(8):1208-11
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  • [Title] Ameloblastoma of the mandible with pulmonary metastases 45 years after initial diagnosis.
  • Ameloblastoma of the mandible is a rare odontogenic tumour that rarely metastasizes.
  • We report a patient with a slowly progressing ameloblastoma of the mandible diagnosed at the age of seven and resected multiple times due to tumour recurrence.
  • Multiple pulmonary metastatic nodules were resected at thoracotomy 27 years after the initial diagnosis; however, further pulmonary disease was discovered.
  • [MeSH-major] Ameloblastoma / diagnosis. Ameloblastoma / secondary. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 19732391.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 26
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70. Kumamoto H, Ooya K: Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors. J Oral Pathol Med; 2006 Nov;35(10):606-12
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  • METHODS: Tissue specimens of 11 tooth germs, 44 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against PD-ECGF/TP and angiopoietin-1 and -2.
  • RESULTS: Immunohistochemical reactivity for PD-ECGF/TP was detected in mesenchymal cells in tooth germs and stromal cells in ameloblastic tumors, and the level of immunoreactivity for PD-ECGF/TP was significantly higher in ameloblastomas than in tooth germs.
  • Granular cell ameloblastomas showed PD-ECGF/TP reactivity in granular neoplastic cells as well as in stromal cells.
  • Malignant ameloblastic tumors had decreased angiopoietin-1 reactivity and ameloblastic carcinomas had increased angiopoietin-2 reactivity as compared with the respective levels in tooth germs and ameloblastomas.
  • Immunohistochemical reactivity for angiopoietin-2 was slightly higher in follicular ameloblastomas than in plexiform ameloblastomas.
  • CONCLUSION: Expression of PD-ECGF/TP and angiopoietin-1 and -2 in tooth germs and ameloblastic tumors suggests that these angiogenic factors participate in tooth development and odontogenic tumor progression by regulating angiogenesis.
  • Altered expression of PD-ECGF/TP and angiopoietins in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / chemistry. Angiopoietin-1 / analysis. Angiopoietin-2 / analysis. Jaw Neoplasms / chemistry. Thymidine Phosphorylase / analysis

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  • (PMID = 17032393.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ANGPT1 protein, human; 0 / Angiopoietin-1; 0 / Angiopoietin-2; EC 2.4.2.4 / Thymidine Phosphorylase
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71. Ponniah I, Murali Gopika Manoharan GV, SureshKumar P, Karthikeyan K: How to name it: a rare case of odontogenic cyst. J Oral Pathol Med; 2007 Oct;36(9):563-9
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  • The categorization of this lesion was complicated by the presence of features suggestive of both glandular odontogenic cyst and cystic ameloblastoma with aggressive histologic phenotypes.
  • [MeSH-minor] Aged. Ameloblastoma / diagnosis. Diagnosis, Differential. Humans. Male. Peripheral Nerves / pathology. Salivary Glands, Minor / pathology. Terminology as Topic. Tomography, X-Ray Computed

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  • (PMID = 17850442.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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72. Brooks JK, Al-Mubarak H, Ribera MJ, Cohen PD, Ross DS, Scheper MA: Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma. Quintessence Int; 2010 Mar;41(3):209-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma.
  • Ameloblastomas are benign aggressive odontogentic tumors that exhibit insidious growth rates with attainment of extensive dimesions.
  • Because ameloblastomas are not usually symptomatic until late in their clinical course, few are detected early.
  • This article reports an atypical case of a small, painful ameloblastoma arising between the roots of the mandibular left canine and lateral incisor in a 66-year-old female.
  • Histopathology revealed a "hybrid" ameloblastoma with a pronounced desmoplastic pattern and acanthomatous changes.
  • Timely recognition and intervention of ameloblastomas may improve treatment outcomes.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 20213021.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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73. Dunfee BL, Sakai O, Pistey R, Gohel A: Radiologic and pathologic characteristics of benign and malignant lesions of the mandible. Radiographics; 2006 Nov-Dec;26(6):1751-68
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  • Benign solid tumors represent a broad spectrum of lesions such as ameloblastomas, odontomas, ossifying fibromas, and periapical cemental dysplasia.

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  • [Copyright] RSNA, 2006
  • (PMID = 17102048.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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74. Gerzenshtein J, Zhang F, Caplan J, Anand V, Lineaweaver W: Immediate mandibular reconstruction with microsurgical fibula flap transfer following wide resection for ameloblastoma. J Craniofac Surg; 2006 Jan;17(1):178-82
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  • [Title] Immediate mandibular reconstruction with microsurgical fibula flap transfer following wide resection for ameloblastoma.
  • Ameloblastoma, the most common odontogenic tumor, is a slow growing, localized tumor of the facial skeleton.
  • With follow-up times of 2 to 3 years, there has been no evidence of recurrence and no difficulties with postoperative evaluation for recurrent disease.
  • [MeSH-major] Ameloblastoma / surgery. Bone Transplantation / methods. Mandible / surgery. Mandibular Neoplasms / surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 16432430.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Zhang Y, Ma XL, Zheng Y: [A case with malignant ameloblastoma of larynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 May;43(5):389-90
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  • [Title] [A case with malignant ameloblastoma of larynx].
  • [MeSH-major] Ameloblastoma. Laryngeal Neoplasms

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  • (PMID = 18717322.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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76. Lin C, Li J, Lu N: [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):553-5
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  • RESULTS: Of the 2161 cases, 58.49% (1264/2161) was benign tumors, 33.13% (716/2161) malignant tumors, and 8.38% (181/2161) tumor-like lesions.
  • The most common benign tumors were pleomorphic adenoma, hemangioma, papilloma, adenolymphoma and ameloblastoma.
  • The most common odontogenic tumors was ameloblastoma.
  • [MeSH-minor] Adenolymphoma. Adenoma, Pleomorphic. Ameloblastoma. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. China / epidemiology. Face. Humans. Incidence. Mouth Mucosa. Odontogenic Tumors. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 21122451.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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77. Alaeddini M, Salah S, Dehghan F, Eshghyar N, Etemad-Moghadam S: Comparison of angiogenesis in keratocystic odontogenic tumours, dentigerous cysts and ameloblastomas. Oral Dis; 2009 Sep;15(6):422-7
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  • [Title] Comparison of angiogenesis in keratocystic odontogenic tumours, dentigerous cysts and ameloblastomas.
  • MATERIALS AND METHODS: Microvessel density was assessed in a total of 53 cases including 20 keratocystic odontogenic tumours, 13 DCs and 20 ameloblastomas (14 solid and six unicystic variants).
  • RESULTS: Statistically significant differences in mean microvessel density were observed between keratocystic odontogenic tumours, DCs and solid ameloblastomas (P < 0.001).
  • Mean microvessel density was significantly higher in solid ameloblastomas compared with both keratocystic odontogenic tumours and DCs; and was also significantly higher in keratocystic odontogenic tumours than in DCs.
  • CONCLUSION: Within the limitations of the present study, it can be suggested that angiogenesis may be one of the mechanisms possibly contributing to the different biological behaviours of keratocystic odontogenic tumours, DCs and solid ameloblastomas.
  • [MeSH-major] Ameloblastoma / blood supply. Jaw Diseases / pathology. Jaw Neoplasms / blood supply. Neovascularization, Pathologic / pathology. Odontogenic Cysts / blood supply. Odontogenic Tumors / blood supply

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  • (PMID = 19413675.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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78. da Silva TA, Batista AC, Mendonça EF, Leles CR, Fukada S, Cunha FQ: Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Mar;105(3):333-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative expression of RANK, RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts.
  • STUDY DESIGN: The expression of these molecules was evaluated in solid/multicystic ameloblastomas (n = 12) and unicystic ameloblastomas (n = 8), keratocystic odontogenic tumors (n = 19), dentigerous cysts (n = 9), and dental follicles (n = 9) by immunohistochemistry.
  • With regard to stroma, the number of RANK-positive and RANKL-positive cells was higher in solid/multicystic ameloblastomas compared with dentigerous cysts.
  • Dental follicles had lower numbers of RANK-positive, RANKL-positive, and OPG-positive cells than solid/multicystic ameloblastomas and keratocystic odontogenic tumors.
  • The majority of solid/multicystic ameloblastomas (75%) and unicystic ameloblastomas (62.5%) had higher numbers of RANKL-positive than OPG-positive cells.
  • [MeSH-minor] Ameloblastoma / metabolism. Ameloblastoma / pathology. Cell Count. Epithelial Cells / metabolism. Gene Expression. Humans. Osteolysis / pathology. Root Resorption / pathology. Statistics, Nonparametric. Stromal Cells / metabolism

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  • (PMID = 18061491.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NF-kappa B; 0 / Osteoprotegerin; 0 / RANK Ligand
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79. Odukoya O, Effiom OA: Clinicopathological study of 100 Nigerian cases of ameloblastoma. Niger Postgrad Med J; 2008 Mar;15(1):1-5
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  • [Title] Clinicopathological study of 100 Nigerian cases of ameloblastoma.
  • SUMMARY: Clinicopathological analysis and growth rate study of 100 cases of ameloblastoma was undertaken.
  • The estimated monthly growth rate (EMGR) of ameloblastoma was observed to be slower in males although the mean tumour volume recorded in females was lower than males in the series.
  • The biologic aggression of 4 various types of ameloblastoma was predicted using EMGR and average volume of tumour at hospital presentation as predictive markers.
  • Solid multicystic ameloblastoma was observed with the fastest EMGR of 0.81 cm(3)/month.
  • Peripheral ameloblastoma was observed with the slowest EMGR of 0.17 cm(3)/ month.
  • It was concluded that all the 4 types of ameloblastoma observed were clinically distinct and showed varying biologic aggression.
  • It is therefore necessary to distinguish between the various clinical types of ameloblastoma before a clinician proceeds with definitive treatment.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology

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  • (PMID = 18408774.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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80. Dhanuthai K, Banrai M, Limpanaputtajak S: A retrospective study of paediatric oral lesions from Thailand. Int J Paediatr Dent; 2007 Jul;17(4):248-53
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  • The top ten most frequently encountered lesions in the present study were dentigerous cyst, mucocele, pyogenic granuloma, ameloblastoma, radicular cyst, odontoma, odontogenic keratocyst, irritation fibroma (focal fibrous hyperplasia), fibrous dysplasia, and osteomyelitis.

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  • (PMID = 17559451.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Poomsawat S, Punyasingh J, Vejchapipat P: Expression of basement membrane components in odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Nov;104(5):666-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: The objective was to characterize the expression of BMCs (laminins 1 and 5, collagen type IV, and fibronectin) in ameloblastomas, calcifying cystic odontogenic tumors (CCOTs), and adenomatoid odontogenic tumors (AOTs).
  • STUDY DESIGN: BMCs were analyzed in 14 ameloblastomas, 7 CCOTs, and 7 AOTs using immunohistochemistry.
  • In all tumors studied, linear deposits of all proteins were found at the epithelial-mesenchymal junction; laminin 1 was expressed in all tumor cells, regardless of cell types.
  • For AOTs, laminin 5 strongly decorated tumor cells adjacent to mineralization.
  • [MeSH-major] Ameloblastoma / pathology. Basement Membrane / pathology. Jaw Neoplasms / pathology. Odontogenic Cyst, Calcifying / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17150384.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Adhesion Molecules; 0 / Collagen Type IV; 0 / Fibronectins; 0 / Laminin; 0 / kalinin; 0 / laminin 1
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82. Sathi GS, Nagatsuka H, Tamamura R, Fujii M, Gunduz M, Inoue M, Rivera RS, Nagai N: Stromal cells promote bone invasion by suppressing bone formation in ameloblastoma. Histopathology; 2008 Oct;53(4):458-67
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  • [Title] Stromal cells promote bone invasion by suppressing bone formation in ameloblastoma.
  • AIMS: To study the stromal variation and role of stromal-tumour cell interaction in impaired bone formation as well as enhanced bone resorption in ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Bone and Bones / metabolism. Jaw Neoplasms / pathology. Osteogenesis / physiology. Stromal Cells / metabolism
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, Differentiation, Myelomonocytic / metabolism. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Bone Resorption / metabolism. Bone Resorption / pathology. Female. Humans. Interleukin-6 / metabolism. Male. Membrane Proteins / metabolism. Middle Aged. Neoplasm Invasiveness. Osteoblasts / metabolism. Osteoclasts / metabolism. Osteoclasts / pathology. RANK Ligand / metabolism. Tumor Cells, Cultured

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  • (PMID = 18983611.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Interleukin-6; 0 / Membrane Proteins; 0 / RANK Ligand; 0 / SFRP2 protein, human
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83. Oral pathology quiz #50. Case number 3. Ameloblastoma. J N J Dent Assoc; 2006;77(1):24-5, 34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral pathology quiz #50. Case number 3. Ameloblastoma.
  • [MeSH-major] Ameloblastoma / radiography. Mandibular Neoplasms / radiography

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  • (PMID = 16710931.001).
  • [ISSN] 0093-7347
  • [Journal-full-title] Journal of the New Jersey Dental Association
  • [ISO-abbreviation] J N J Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Isomura ET, Okura M, Ishimoto S, Yamada C, Ono Y, Kishino M, Kogo M: Case report of extragingival peripheral ameloblastoma in buccal mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Oct;108(4):577-9
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  • [Title] Case report of extragingival peripheral ameloblastoma in buccal mucosa.
  • A peripheral ameloblastoma (PA) is a rare variant of ameloblastoma that generally occurs in the extraosseous region; an extragingival PA is extremely rare.
  • [MeSH-major] Ameloblastoma / diagnosis. Cheek / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / diagnosis

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  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May;109(5):653-4; author reply 654-5 [20416529.001]
  • [ErratumIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Feb;109(2):324. Yamada, Tomoaki [corrected to Yamada, Chiaki]
  • (PMID = 19778743.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Kotrashetti VS, Kale AD, Bhalaerao SS, Hallikeremath SR: Histopathologic changes in soft tissue associated with radiographically normal impacted third molars. Indian J Dent Res; 2010 Jul-Sep;21(3):385-90
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  • Of 41 tissues evaluated, histopathological reports of 18 follicles were suggestive of dentigerous cyst, two follicles showed odontogenic keratocyst, one follicle each of calcifying epithelial odontogenic cyst, ameloblastoma-like proliferation, odontogenic myxoma and odontogenic fibroma.
  • [MeSH-minor] Adolescent. Adult. Ameloblastoma / pathology. Asymptomatic Diseases. Dental Enamel / pathology. Dental Sac / pathology. Dentigerous Cyst / pathology. Epithelium / pathology. Female. Gingival Diseases / pathology. Humans. Male. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Odontogenic Cyst, Calcifying / pathology. Odontogenic Cysts / pathology. Odontogenic Tumors / pathology. Prospective Studies. Radiography, Panoramic. Young Adult

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  • (PMID = 20930350.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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86. Moreira PR, Guimarães MM, Gomes CC, Diniz MG, Brito JA, de Castro WH, Gomez RS: Methylation frequencies of cell-cycle associated genes in epithelial odontogenic tumours. Arch Oral Biol; 2009 Oct;54(10):893-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This group includes lesions of different biological behaviour, such as ameloblastoma, calcifying cystic odontogenic tumour (CCOT) and adenomatoid odontogenic tumour (AOT).
  • DESIGN: Methylation-specific polymerase chain reaction (MSP) was used to evaluate the presence of methylation in 13 samples of ameloblastoma, six samples of CCOT, three samples of AOT and 14 samples of dental follicles, included as control.
  • In ameloblastoma, the highest methylated genes were P16 and P21, while in CCOT the P21 and RB1 genes were the most commonly methylated genes.
  • [MeSH-minor] Adenoma / genetics. Adenoma / metabolism. Ameloblastoma / genetics. Ameloblastoma / metabolism. Dental Sac / metabolism. Epithelial Cells / metabolism. Humans. Odontogenic Cyst, Calcifying / genetics. Odontogenic Cyst, Calcifying / metabolism. Polymerase Chain Reaction / methods

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  • (PMID = 19679296.001).
  • [ISSN] 1879-1506
  • [Journal-full-title] Archives of oral biology
  • [ISO-abbreviation] Arch. Oral Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins
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87. Smullin SE, Faquin W, Susarla SM, Kaban LB: Peripheral desmoplastic ameloblastoma: report of a case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jan;105(1):37-40
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  • [Title] Peripheral desmoplastic ameloblastoma: report of a case and literature review.
  • The desmoplastic variant of ameloblastoma is a rare, locally invasive, benign tumor of the jaws, typically found in the anterior regions of the maxilla and mandible.
  • This ameloblastoma variant has been described as an intraosseous tumor; to our knowledge, there have been no published cases of a peripheral desmoplastic ameloblastoma.
  • The purpose of this case report is to describe a patient with a desmoplastic ameloblastoma localized to the soft tissue of the palate with no osseous involvement.
  • [MeSH-major] Ameloblastoma / pathology. Palatal Neoplasms / pathology

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  • (PMID = 17764981.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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88. Papagelopoulos PJ, Mavrogenis AF, Galanis EC, Savvidou OD, Inwards CY, Sim FH: Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones. Orthopedics; 2007 Mar;30(3):211-5; quiz 216-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / therapy. Bone Neoplasms / diagnosis. Bone Neoplasms / therapy. Tibia / pathology

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  • (PMID = 17375547.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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89. Jundt G, Reichart PA: [Malignant odontogenic tumors]. Pathologe; 2008 May;29(3):205-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Maligne odontogene Tumoren.
  • Odontogenic carcinomas comprise ameloblastic carcinoma (AmCa), primary intraosseous carcinoma (PIOC), clear cell odontogenic carcinoma, odontogenic ghost cell carcinoma (OGCC), and the special case of metastasizing ameloblastoma.
  • Whereas metastasizing ameloblastoma can be diagnosed only after having metastasized, all other malignant odontogenic tumors present with atypia, increased cellularity and mitoses, and invasion.
  • [MeSH-minor] Ameloblastoma / classification. Ameloblastoma / pathology. Carcinoma / classification. Carcinoma / pathology. Carcinosarcoma / classification. Carcinosarcoma / pathology. Diagnosis, Differential. Humans. Jaw / pathology. Neoplasm Invasiveness. Sarcoma / classification. Sarcoma / pathology

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  • [Cites] J Craniomaxillofac Surg. 2005 Oct;33(5):352-5 [16129612.001]
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  • (PMID = 18392827.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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90. Capote-Moreno A, Acero J, García-Recuero I, Ruiz J, Serrano R, de Paz V: Giant aneurysmal bone cyst of the mandible with unusual presentation. Med Oral Patol Oral Cir Bucal; 2009 Mar;14(3):E137-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aneurysmal bone cysts are non-neoplastic but locally aggressive tumours with occasional rapid growth that may be differentiated from other multilocular process like ameloblastoma, ossifying fibroma, epithelial cyst, giant cell granuloma and sarcomas.

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  • (PMID = 19242394.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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91. Abada RL, Kadiri F, Tawfik N, Benchakroun N, Bouchbika Z, Chekkoury AI, Benchakroun Y, Benider A: [Multiple metastases of a mandibular ameloblastoma]. Rev Stomatol Chir Maxillofac; 2005 Jun;106(3):177-80
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  • [Title] [Multiple metastases of a mandibular ameloblastoma].
  • INTRODUCTION: Ameloblastoma is a benign odontogenic tumor which can be locally aggressive and invasive.
  • Metastases are rare but possible and must be considered as a malignant form of the tumor.
  • OBSERVATION: A 50-year-old woman presented a jugal metastasis of a mandibular ameloblastom which had been treated several times 28 years earlier.
  • DISCUSSION: The absence of any histological sign of malignity in the primary tumor and in the metastases, as observed in our patient, is remarkable.
  • Progression is very slow, like for the primary tumor.
  • Several factors predictive of metastasis have been described: female gender, age at onset of primary tumor (2nd to 3rd decade) and multiple local recurrences.
  • [MeSH-major] Ameloblastoma / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 15976707.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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92. Vered M, Shohat I, Buchner A, Dayan D: Myofibroblasts in stroma of odontogenic cysts and tumors can contribute to variations in the biological behavior of lesions. Oral Oncol; 2005 Nov;41(10):1028-33
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  • The study included cases of dentigerous cyst (DC, n = 7), odontogenic keratocyst-parakeratinized type (OKC-P, n = 8), orthokeratinized type (OKC-O, n = 9), ameloblastic fibroma/fibro-odontoma (AMF/O, n = 11), unicystic ameloblastoma (UAM, n = 6), and solid ameloblastoma (SAM, n = 7).

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  • (PMID = 16139563.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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93. Mutave R, Chindia ML, Guthua SW: Post-operative re-construction of dentoalveolar tissue and the mandible and maxillae using prosthetic therapy. East Afr Med J; 2005 Jun;82(6):311-3
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  • Individual patient follow-up periods ranged from seven days for two patients who had cyst enucleation to two years for three cases with ameloblastoma, and two cases with squamous cell carcinoma.

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  • (PMID = 16175783.001).
  • [ISSN] 0012-835X
  • [Journal-full-title] East African medical journal
  • [ISO-abbreviation] East Afr Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Kenya
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94. Luo HY, Yu SF, Li TJ: Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. Int J Oral Maxillofac Surg; 2006 Aug;35(8):750-5
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  • [Title] Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas.
  • To evaluate the expression patterns of apoptosis-related proteins, including Fas, Fas-ligand (FasL), caspase-3 and Bcl-2, in various cellular components of ameloblastomas, 39 cases of ameloblastoma were examined using immunohistochemistry.
  • The differential expression of apoptosis-related proteins in various cellular components of ameloblastomas, with pro-apoptotic proteins, Fas, FasL and caspase-3 being closely associated with squamous metaplasia and granular transformation of the tumour cells, suggests that Fas/FasL-induced apoptotic cell death may play a role in the disposal of terminally differentiated or degenerative tumour cells in ameloblastomas.
  • [MeSH-major] Ameloblastoma / chemistry. Caspases / analysis. Jaw Neoplasms / chemistry. Membrane Glycoproteins / analysis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis. Receptors, Tumor Necrosis Factor / analysis. Tumor Necrosis Factors / analysis

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  • (PMID = 16690252.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / BCL2L15 protein, human; 0 / FAS protein, human; 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / Membrane Glycoproteins; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Receptors, Tumor Necrosis Factor; 0 / Tumor Necrosis Factors; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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95. Gonçalves R, Saad Junior R, Dorgan Neto V, Botter M: [A rare case of pneumothorax: metastatic adamantinoma]. J Bras Pneumol; 2008 Jun;34(6):425-9
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  • [Title] [A rare case of pneumothorax: metastatic adamantinoma].
  • [Transliterated title] Caso raro de pneumotórax: adamantinoma metastático.
  • Here, we describe two cases of lung metastasis of adamantinoma of long bones, a low-grade bone neoplasm that rarely metastasizes.
  • In both cases, the clinical presentation of the metastases was characterized by spontaneous pneumothorax secondary to tumor cavitation, a phenomenon described in only three of the studies reviewed in the literature.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Lung Neoplasms / secondary. Pneumothorax / etiology

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  • (PMID = 18622511.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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96. Mikou A, Al Bouzidi A, Kabbaj R, Chahdi H, Kamous W, Zoubeir Y, Rharrassi I, Rimani M, Labraimi A, El Khatib M, Rzin A, Nassih M: [Desmoplastic ameloblastoma in a 7 year old child]. Rev Laryngol Otol Rhinol (Bord); 2008;129(4-5):341-3
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  • [Title] [Desmoplastic ameloblastoma in a 7 year old child].
  • Desmoplastic ameloblastoma is a benign, locally aggressive neoplasm of proliferating odontogenic epithelial origin.
  • A curetting of the lesion was carried out and the anatomopathologic examination retained the diagnosis of desmoplastic ameloblastoma.
  • In addition, the desmoplastic ameloblastoma is relatively rare, is characterized by an anatomical distribution, a radiological appearance and a morphological aspect differents from the traditional ameloblastoma.
  • [MeSH-major] Ameloblastoma. Jaw Neoplasms

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  • (PMID = 19408524.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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97. Abiko Y, Nagayasu H, Takeshima M, Yamazaki M, Nishimura M, Kusano K, Kitajo H, Saitoh M, Kawakami T, Chiba I, Kaku T: Ameloblastic carcinoma ex ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jan;103(1):72-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastic carcinoma ex ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation.
  • Ameloblastic carcinoma meeting the WHO criteria may arise either as a result of malignant change in a pre-existing benign ameloblastoma (carcinoma ex ameloblastoma) or as a primary malignant ameloblastoma not preceded by an ordinary ameloblastoma (de novo carcinoma).
  • We report a case of ameloblastic carcinoma ex ameloblastoma and examine how this case underwent malignant transformation.
  • The DNA was extracted separately from benign and malignant areas in paraffin sections of the tumor.
  • Hypermethylation of CpG islands of the p16 gene was detected in the malignant parts of the tumor.
  • The results indicate that hypermethylation of p16 may have been involved in the malignant transformation of the ameloblastoma in the present case.
  • [MeSH-major] Ameloblastoma / genetics. Cell Transformation, Neoplastic / genetics. CpG Islands / genetics. DNA Methylation. Genes, p16. Mandibular Neoplasms / genetics

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  • (PMID = 17178497.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / PDRG1 protein, human
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98. Atalay B, Soluk M, Brkić A, Emes Y, Cetin O, Olgac V: Desmoplastic ameloblastoma. J Craniofac Surg; 2009 Nov;20(6):2256-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic ameloblastoma.
  • Ameloblastoma is a rare benign odontogenic epithelial tumor characterized by abnormal cell growth, which easily infiltrates and destroys surrounding bony tissues.
  • One of the 3 clinical variants of ameloblastoma is desmoplastic type, with involvement of the maxillary arch more often than the mandible.
  • Its histopathologic variant characterized by extensive squamous metaplasia, islands of tumor cells, and sometimes keratin formation is known as desmoplastic acanthomatous ameloblastoma.The aim of this report was to present an unusual case of symphysis located desmoplastic acanthomatous ameloblastoma in a 56-year-old female patient, who was experiencing laryngeal carcinoma 2 years ago.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 19934686.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Tamme T, Tiigimäe J, Leibur E: Mandibular ameloblastoma: a 28-years retrospective study of the surgical treatment results. Minerva Stomatol; 2010 Nov-Dec;59(11-12):637-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mandibular ameloblastoma: a 28-years retrospective study of the surgical treatment results.
  • AIM: The aim of this study was to analyse the long-term treatment results of mandibular ameloblastomas over a 28-year period and determine the most appropriate method of management of these tumours.
  • METHODS: Sixteen patients with a diagnosis of mandibular ameloblastoma treated in our Department between January 1977 and December 2004 were selected for this retrospective study.
  • CONCLUSION: In summary, conservative treatment enucleation should be used only in the treatment of unicystic ameloblastoma, while the radical approach, resection with some safe margin, should be the first choice in the treatment of solid, multicystic mandibular ameloblastoma to avoid recurrence.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery

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  • (PMID = 21217628.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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100. Mavrogenis AF, Sakellariou VI, Tsibidakis H, Papagelopoulos PJ: Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant. J Int Med Res; 2009 Jul-Aug;37(4):1238-45
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  • [Title] Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant.
  • Histological diagnosis was consistent with adamantinoma, a rare primary bone tumour.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Limb Salvage / methods. Tibia / pathology. Tibia / surgery

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  • (PMID = 19761710.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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