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Items 1 to 100 of about 102
1. Donkor P, Bankas DO, Boakye G, Ansah S, Acheampong A: The use of free autogenous rib grafts in maxillofacial reconstruction. Ghana Med J; 2006;40(4):127-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The indications for grafting included ameloblastoma, malignant disease, cyst, ankylosis, and trauma.

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  • (PMID = 17568822.001).
  • [ISSN] 0016-9560
  • [Journal-full-title] Ghana medical journal
  • [ISO-abbreviation] Ghana Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ghana
  • [Other-IDs] NLM/ PMC1891270
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2. Mukhopadhyay S, Raha K, Mondal SC: Huge ameloblastoma of jaw-A case report. Indian J Otolaryngol Head Neck Surg; 2005 Jul;57(3):247-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Huge ameloblastoma of jaw-A case report.
  • Ameloblastoma is a tumor of odontogenic epithelium.
  • It is a tumour of intermediate malignant potential which lies in the gray zone between benign and malignant neoplasm.
  • A huge ameloblastoma revealing benign cytological features in FNAC is being reported.Ameloblastoma arises from odontogenic epithelium.
  • This tumor shows invasive property and a remarkable tendency of recurrence.
  • The cases showing distant metastasis are recognized as malignant ameloblastoma.
  • Ameloblastic carcinoma is a tumor with microscopic features of ameloblastoma that displays malignant features at cytological level.([2]) It usually has aggressive course.
  • A case of large ameloblastoma with slow clinical course and benign cytological as well as histological features is being reported.

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  • [Cites] Oral Surg Oral Med Oral Pathol. 1984 Feb;57(2):168-76 [6366686.001]
  • (PMID = 23120181.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451340
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3. Powers J, Zhao Y, Lin S, McCabe ER: The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation. Dev Genes Evol; 2009 Aug;219(8):419-25
ZFIN. ZFIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation.
  • Based on the zebrafish observations, we demonstrated novel DAX1 expression in normal human dental, benign ameloblastoma, and malignant ameloblastoma tissues.
  • The association of NR0B1 and its protein product DAX1 with primary tooth development and ameloblastoma tumorigenesis is an association not previously described.
  • [MeSH-minor] Ameloblastoma / genetics. Animals. Embryo, Nonmammalian / metabolism. Gene Expression Regulation, Developmental. Homeodomain Proteins. Humans. Tooth / embryology

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  • (PMID = 19826837.001).
  • [ISSN] 1432-041X
  • [Journal-full-title] Development genes and evolution
  • [ISO-abbreviation] Dev. Genes Evol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DAX-1 Orphan Nuclear Receptor; 0 / Homeodomain Proteins; 0 / NR0B1 protein, human; 0 / Zebrafish Proteins
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4. Napp M, Stengel BA, Buschmann J, Döhler JR: [Osteofibrous dysplasia campanacci of the tibia. A 12-year follow-up]. Chirurg; 2009 Mar;80(3):241-4
MedlinePlus Health Information. consumer health - Leg Injuries and Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Osteofibrous dysplasia campanacci of the tibia. A 12-year follow-up].
  • [Transliterated title] Osteofibröse Dysplasie Campanacci der Tibia : Ein 12-Jahres-Follow-up.
  • The case is presented of a girl with stress fracture, distinct antecurvation, relapse, and refracture.
  • Despite the controversial indication, we recommend this method due to the disorder's putative relationship with malignant adamantinoma.
  • [MeSH-minor] Bone Transplantation. Child. Diagnosis, Differential. Female. Follow-Up Studies. Fracture Fixation, Internal / methods. Fracture Healing / physiology. Humans. Osteoblasts / pathology. Postoperative Complications / diagnostic imaging. Postoperative Complications / pathology. Postoperative Complications / surgery. Radiography. Recurrence. Tibia / pathology. Tibia / surgery

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  • (PMID = 18690418.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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5. Sharma S, Kumar D, Vashistha A, Bihani U, Trehan M: Recurrent unicystic ameloblastoma of the infratemporal and temporal fossa. Int J Clin Pediatr Dent; 2009 Jan;2(1):33-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent unicystic ameloblastoma of the infratemporal and temporal fossa.
  • The ameloblastoma has been described as benign but locally invasive; benign and locally invasive with strong tendency to recur; and locally malignant.

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  • (PMID = 25206097.001).
  • [ISSN] 0974-7052
  • [Journal-full-title] International journal of clinical pediatric dentistry
  • [ISO-abbreviation] Int J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4086554
  • [Keywords] NOTNLM ; Unicystic / ameloblastoma / infratemporal temporal.
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6. Zhang B, Zhang J, Xu ZY, Xie HL: Expression of RECK and matrix metalloproteinase-2 in ameloblastoma. BMC Cancer; 2009;9:427

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of RECK and matrix metalloproteinase-2 in ameloblastoma.
  • BACKGROUND: Ameloblastoma is a frequent odontogenic benign tumor characterized by local invasiveness, high risk of recurrence and occasional metastasis and malignant transformation.
  • The aim of this study was to characterize the relationship between RECK and MMP-2 expression and the clinical manifestation of ameloblastoma.
  • METHODS: Immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) were employed to detect the protein and mRNA expression of RECK and MMP-2 in keratocystic odontogenic tumor (KCOT), ameloblastoma and ameloblastic carcinoma.
  • RESULTS: RECK protein expression was significantly reduced in KCOT (87.5%), ameloblastoma (56.5%) and ameloblastic carcinoma (0%) (P < 0.01), and was significantly lower in recurrent ameloblastoma compared with primary ameloblastoma (P < 0.01), but did not differ by histological type of ameloblastoma.
  • MMP-2 protein expression was significantly higher in ameloblastoma and ameloblastic carcinoma compared with KCOT (P < 0.01).
  • RECK mRNA expression was significantly lower in ameloblastoma than in KCOT (P < 0.01), lower in recurrent ameloblastoma than in primary ameloblastoma, and was negative in ameloblastic carcinoma.
  • MMP-2 mRNA expression was significantly higher in ameloblastoma compared with KCOT (P < 0.01), but was no different in recurrent ameloblastoma versus primary ameloblastoma.
  • RECK protein expression was negatively associated with MMP-2 protein expression in ameloblastoma (r = -0.431, P < 0.01).
  • CONCLUSION: Low or no RECK expression and increased MMP-2 expression may be associated with negative clinical findings in ameloblastoma.
  • RECK may participate in the invasion, recurrence and malignant transformation of ameloblastoma by regulating MMP-2 at the post-transcriptional level.
  • [MeSH-major] Ameloblastoma / metabolism. Jaw Neoplasms / metabolism. Matrix Metalloproteinase 2 / biosynthesis. Membrane Glycoproteins / biosynthesis

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  • (PMID = 19995435.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / RECK protein, human; 0 / RNA, Messenger; EC 3.4.24.24 / Matrix Metalloproteinase 2
  • [Other-IDs] NLM/ PMC2794878
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7. Rastogi V, Pandilwar PK, Maitra S: Ameloblastoma: an evidence based study. J Maxillofac Oral Surg; 2010 Jun;9(2):173-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma: an evidence based study.
  • OBJECTIVE: The purpose of this study is to present a series of 46 cases of ameloblastoma-38 in mandible and 8 in maxilla treated in the Oral and Maxillofacial Surgery Department of Government Dental College and Hospital, Nagpur during 1997-2006 with emphasis on various treatment modalities used in treating different types of ameloblastoma and how to define the safe margin for different clinical and histopathological types of ameloblastoma with their follow-up.
  • RESULT: In a follow-up period of 1-9 years recurrence was observed in six cases, two in patients treated with enucleation and curettage, three in patients treated with segmental resection and one in patient with peripheral ameloblastoma treated with soft tissue resection.

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  • (PMID = 22190781.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3244084
  • [Keywords] NOTNLM ; Ameloblastoma / Biopsy / Malignant / Mandible / Multicystic
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8. Reid-Nicholson M, Teague D, White B, Ramalingam P, Abdelsayed R: Fine needle aspiration findings in malignant ameloblastoma: a case report and differential diagnosis. Diagn Cytopathol; 2009 Aug;37(8):586-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration findings in malignant ameloblastoma: a case report and differential diagnosis.
  • We present a case of malignant ameloblastoma presenting in the posterior mandible and cervical lymph nodes of an African American child.
  • This partly clinical as well as cytologic diagnosis was facilitated by the presence of typical ameloblastoma cytology in multiple cervical lymph nodes adjacent to the histologically confirmed intraosseous ameloblastoma.
  • Although cytology is helpful in diagnosing ameloblastoma, its features are by no means definitive as there are several cytologic mimics.
  • A high index of suspicion is therefore necessary to confirm or exclude ameloblastoma when evaluating any jaw lesion and/or adjacent enlarged lymph nodes by cytologic examination.
  • Adequate sampling is paramount to accurate diagnosis, and is especially important when attempting to distinguish ameloblastoma from ameloblastic carcinoma.
  • [MeSH-major] Ameloblastoma / diagnosis. Ameloblastoma / pathology. Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / pathology
  • [MeSH-minor] Adolescent. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19373909.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Van Dam SD, Unni KK, Keller EE: Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg; 2010 Dec;68(12):2962-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience.
  • PURPOSE: To provide a comprehensive review of metastasizing (malignant) ameloblastoma, establish a new baseline of valid cases using histologic criteria and minimum documentation, and report 3 cases from the Mayo Clinic files.
  • PATIENTS AND METHODS: Ninety-eight original reports of "metastasizing," "malignant," or "atypical" ameloblastoma were reviewed.
  • The following data were gathered for reports that demonstrated well-differentiated ameloblastoma at the metastatic site: gender, ethnicity, age at time of primary tumor diagnosis, histologic pattern of primary tumor, anatomic sites of primary and metastatic tumors, interval from diagnosis of primary to diagnosis of metastasis, number of recurrences preceding metastasis, treatment responses to radiation and/or chemotherapy, presence of hypercalcemia, and length of survival after metastasis.
  • RESULTS: Twenty-seven valid reports of metastasizing (malignant) ameloblastoma were identified; 81% originated in the mandible, recurring on average 4 times before metastasis.
  • The average time from diagnosis of primary to metastasis was 18 years.
  • Over half of the patients were alive and had survived an average of 10 years since diagnosis of metastasis.
  • Those patients who had succumbed to their disease had an average survival time of 3 years after diagnosis of metastasis.
  • CONCLUSIONS: Metastasis of well-differentiated ameloblastoma occurs more rarely than previously believed.
  • The absence of malignant cytologic transformation correlates with relatively indolent metastatic site growth.
  • Treatment of metastasizing (malignant) ameloblastoma should include close observation, thoracotomy with wedge resections, or experimental chemotherapeutic combinations.
  • [MeSH-major] Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology

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  • [Copyright] Copyright © 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20970910.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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10. Gleason BC, Liegl-Atzwanger B, Kozakewich HP, Connolly S, Gebhardt MC, Fletcher JA, Perez-Atayde AR: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol; 2008 Mar;32(3):363-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal.
  • Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals.
  • Although OFD has typical histopathologic features, areas resembling OFD have often been noted at the periphery of otherwise classic adamantinomas, and some have suggested that OFD may be either a precursor to or a regressive phase of adamantinoma.
  • The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma.
  • Patients with OFD were generally younger than those with adamantinoma.
  • Osteoblastic and osteoclastic activity was more prominent in OFD than in OFD-like adamantinoma.
  • In addition to the inconspicuous small clusters of epithelial cells in OFD-like adamantinoma, isolated keratin-positive cells with a unique ultrastructural hybrid fibroblastic-epithelial phenotype were found in the stroma of all OFD and OFD-like adamantinomas.
  • Fluorescence in situ hybridization analysis revealed trisomies 7, 8, and/or 12 in the spindle cell stroma of OFD, OFD-like, and classic adamantinoma, supporting a neoplastic origin of OFD and a common histogenesis for all 3 lesions.
  • Of the 11 OFD patients with follow-up (median, 4.5 y), all 3 who underwent incisional biopsy had persistent, nonprogressive disease and 2 of 8 who underwent curettage or wide excision had recurrence; none developed adamantinoma.
  • All 6 adamantinoma patients with follow-up (3 classic and 3 OFD-like) were treated with wide excision.
  • One with classic adamantinoma died of pulmonary metastases 9 years after presentation; the other 5 were free of disease with a median follow-up of 12 years.
  • None of the classic adamantinomas evolved into OFD-like adamantinoma or OFD.
  • Although the histopathology, immunohistochemistry, ultrastructure, and cytogenetics indicate that these lesions are closely related, our data and the literature suggest that only classic adamantinoma has malignant potential.
  • OFD, OFD-like adamantinoma, and classic adamantinoma appear to show a progressive complexity of cytogenetic aberrations, perhaps indicative of a multistep neoplastic transformation.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Fibrous Dysplasia of Bone / pathology

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  • (PMID = 18300815.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Jundt G, Reichart PA: [Malignant odontogenic tumors]. Pathologe; 2008 May;29(3):205-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Malignant odontogenic tumors].
  • [Transliterated title] Maligne odontogene Tumoren.
  • Malignant odontogenic tumors are extremely rare.
  • As with benign odontogenic tumors, malignant epithelial odontogenic tumors or odontogenic carcinomas are distinguished from the even rarer mesenchymal ones, the odontogenic sarcomas.
  • Odontogenic carcinomas comprise ameloblastic carcinoma (AmCa), primary intraosseous carcinoma (PIOC), clear cell odontogenic carcinoma, odontogenic ghost cell carcinoma (OGCC), and the special case of metastasizing ameloblastoma.
  • Whereas metastasizing ameloblastoma can be diagnosed only after having metastasized, all other malignant odontogenic tumors present with atypia, increased cellularity and mitoses, and invasion.
  • Odontogenic carcinomas, however, especially AmCa, OGCC, and PIOC, are more aggressive, with a 5-year survival rate of about 70% for AmCa and OGCC and a 3-year survival rate of about 37% for PIOC.
  • [MeSH-minor] Ameloblastoma / classification. Ameloblastoma / pathology. Carcinoma / classification. Carcinoma / pathology. Carcinosarcoma / classification. Carcinosarcoma / pathology. Diagnosis, Differential. Humans. Jaw / pathology. Neoplasm Invasiveness. Sarcoma / classification. Sarcoma / pathology

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  • (PMID = 18392827.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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12. Ricard AS, Majoufre-Lefebvre C, Siberchicot F, Laurentjoye M: A multirecurrent ameloblastoma metastatic to the lung. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):98-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A multirecurrent ameloblastoma metastatic to the lung.
  • INTRODUCTION: The ameloblastoma is a rare tumor of odontogenic epithelial origin.
  • We present a case of a multirecurrent ameloblastoma of the mandible metastatic to the lung.
  • OBSERVATION: We present a case of a mandibular malignant ameloblastoma in a 42-year old man with widespread pulmonary metastases.
  • DISCUSSION: Ameloblastoma metastasis often occurs in the lung.
  • [MeSH-major] Ameloblastoma / pathology. Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology. Mandibular Neoplasms / surgery

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  • (PMID = 20347463.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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13. DeVilliers P, Liu H, Suggs C, Simmons D, Daly B, Zhang S, Raubenheimer E, Larsson A, Wright T: Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor. Am J Surg Pathol; 2008 Feb;32(2):256-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor.
  • Ameloblastoma is a benign, locally aggressive epithelial odontogenic tumor that has the potential to become malignant and produce metastasis to distant sites such as lungs and kidneys.
  • The expression of calretinin [calbindin2 (CALB2)] was investigated on both ameloblastoma and KCOT.
  • Nineteen cases of ameloblastoma and 17 cases of KCOT were stained with calretinin antiserum 18-0211 (Zymed, San Francisco, CA).
  • All cases (100%) of ameloblastoma showed positive calretinin staining, restricted to the neoplastic epithelial component and none (0%) of the 17 KCOTs showed positive calretinin staining.
  • Taken together, the results of this study strongly support calretinin as a useful immunohistochemical marker for ameloblastoma and malignant ameloblastoma and it can also be used in the differential diagnosis of KCOT.
  • [MeSH-major] Ameloblastoma / diagnosis. Biomarkers, Tumor / metabolism. Jaw Neoplasms / diagnosis. Odontogenic Cysts / diagnosis. Odontogenic Tumors / diagnosis. S100 Calcium Binding Protein G / metabolism
  • [MeSH-minor] Calbindin 2. Diagnosis, Differential. Gene Expression. Gene Expression Profiling. Humans. RNA, Messenger / metabolism. RNA, Neoplasm / analysis

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  • (PMID = 18223328.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE016079
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / S100 Calcium Binding Protein G
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14. Zhang ZH, Lu YC, Meng QF, Wu PH: [CT diagnosis of various subtypes of ameloblastoma in the maxillomandibular region]. Ai Zheng; 2006 Oct;25(10):1266-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [CT diagnosis of various subtypes of ameloblastoma in the maxillomandibular region].
  • This study was to explore the clinical and CT imaging features of solid or multicystic ameloblastoma (SMA), unicystic ameloblastoma (UA), and malignant ameloblastoma (MA), and thus to improve the CT diagnostic accuracy for these diseases.
  • Combined analysis of CT images and clinical data is helpful in differentiating these 3 subtypes of ameloblastoma.
  • [MeSH-major] Ameloblastoma / radiography. Mandibular Neoplasms / radiography. Maxillary Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 17059773.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Chen WL, Ouyang KX, Li HG, Huang ZQ, Li JS, Wang JG: Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma. J Craniofac Surg; 2009 Jan;20(1):171-5; discussion 176-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of inducible nitric oxide synthase and vascular endothelial growth factor in ameloblastoma.
  • The purposes of this study were to determine the correlation between the expression of inducible nitric oxide synthase (iNOS) and vascular endothelial growth factor (VEGF) in ameloblastoma and to examine the relationships of this expression to angiogenesis and the clinical and biological behaviors of the tumor.
  • Immunohistochemical staining with streptavidin peroxidase was used to analyze iNOS and VEGF expression, and CD34 was used to evaluate microvascular density (MVD) in 35 ameloblastomas (24 primary tumors and 11 recurrences) and 5 malignant ameloblastomas.
  • On relational analysis, positive and VEGF expression and MVD counts increased in this order: OKCs, primary ameloblastoma, recurrent ameloblastoma, and malignant ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Neovascularization, Pathologic / pathology. Nitric Oxide Synthase Type II / analysis. Vascular Endothelial Growth Factor A / analysis

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  • (PMID = 19165019.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type II
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16. Abiko Y, Nagayasu H, Takeshima M, Yamazaki M, Nishimura M, Kusano K, Kitajo H, Saitoh M, Kawakami T, Chiba I, Kaku T: Ameloblastic carcinoma ex ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Jan;103(1):72-6
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  • [Title] Ameloblastic carcinoma ex ameloblastoma: report of a case-possible involvement of CpG island hypermethylation of the p16 gene in malignant transformation.
  • Ameloblastic carcinoma is described in the updated World Health Organization (WHO) classification as a rare malignant lesion.
  • Ameloblastic carcinoma meeting the WHO criteria may arise either as a result of malignant change in a pre-existing benign ameloblastoma (carcinoma ex ameloblastoma) or as a primary malignant ameloblastoma not preceded by an ordinary ameloblastoma (de novo carcinoma).
  • We report a case of ameloblastic carcinoma ex ameloblastoma and examine how this case underwent malignant transformation.
  • The DNA was extracted separately from benign and malignant areas in paraffin sections of the tumor.
  • Hypermethylation of CpG islands of the p16 gene was detected in the malignant parts of the tumor.
  • The results indicate that hypermethylation of p16 may have been involved in the malignant transformation of the ameloblastoma in the present case.
  • [MeSH-major] Ameloblastoma / genetics. Cell Transformation, Neoplastic / genetics. CpG Islands / genetics. DNA Methylation. Genes, p16. Mandibular Neoplasms / genetics

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  • (PMID = 17178497.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / DNA, Neoplasm; 0 / DNA-Binding Proteins; 0 / PDRG1 protein, human
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17. López-Jornet P, Bermejo-Fenoll A: Peripheral ameloblastoma of the gingiva: the importance of diagnosis. J Clin Periodontol; 2005 Jan;32(1):12-5
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  • [Title] Peripheral ameloblastoma of the gingiva: the importance of diagnosis.
  • BACKGROUND: Peripheral ameloblastoma is an extremely rare epithelial odontogenic tumor, limited to the soft tissues of the gums or oral mucosa.
  • METHODS: The present study describes the case of a 31-year-old male presenting a firm, symptomless tumor mass of irregular appearance and measuring approximately 12 mm in diameter, located in the distal zone of 4.7.
  • The cells in the peripheral zone adopted a palisade distribution, and presented the appearance of a lax reticulum at central level.
  • The diagnosis was peripheral ameloblastoma.
  • CONCLUSIONS: Although the origin of the lesion remains unclear, it is able to recur and undergo malignant transformation.
  • Consequently, peripheral ameloblastoma should not be viewed as a harmless mass.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Diseases / pathology

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  • [Copyright] Copyright Blackwell Munksgaard, 2004.
  • (PMID = 15642052.001).
  • [ISSN] 0303-6979
  • [Journal-full-title] Journal of clinical periodontology
  • [ISO-abbreviation] J. Clin. Periodontol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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18. Senra GS, Pereira AC, Murilo dos Santos L, Carvalho YR, Brandão AA: Malignant ameloblastoma metastasis to the lung: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Feb;105(2):e42-6
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  • [Title] Malignant ameloblastoma metastasis to the lung: a case report.
  • Ameloblastoma is an odontogenic tumor, usually benign, which rarely metastasizes to distant organs.
  • The case of a 27-year-old white woman is described, who presented a metastatic pulmonary ameloblastoma 7 years after the removal of a mandibular ameloblastoma.
  • Computed tomography (CT) revealed a 2-cm well-defined solitary round nodule without calcifications, leading to the hypothesis of a metastatic tumor.
  • Clinical and CT investigation confirmed no ameloblastoma recurrence in the jaw and no other primary tumor.
  • The diagnosis of metastatic ameloblastoma was confirmed by microscopic evaluation of the pulmonary nodule.
  • [MeSH-major] Ameloblastoma / secondary. Lung Neoplasms / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 18230377.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Ladeinde AL, Ogunlewe MO, Bamgbose BO, Adeyemo WL, Ajayi OF, Arotiba GT, Akinwande JA: Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital. Quintessence Int; 2006 Jan;37(1):69-74

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital.
  • OBJECTIVE: The aim of the study was to review all the cases of ameloblastoma seen at the Oral and Maxillofacial Surgery Clinic of the Lagos University Teaching Hospital, Nigeria, between 1980 and 2003.
  • METHODS AND MATERIALS: In this retrospective study, case files and biopsy reports of new cases of ameloblastoma covering a 24-year period were retrieved and analyzed for sex, age on presentation, histologic type, and site distribution.
  • RESULTS: A total of 207 cases of ameloblastoma were seen in the given period.
  • One hundred and ninety-eight (95.7%) were benign, and 9 (4.3%) were malignant.
  • The average ages on presentation for ameloblastoma and ameloblastic carcinoma were 31.67 and 46.44 years, respectively.
  • The most common histologic type was follicular ameloblastoma (25.1%).
  • CONCLUSIONS: Ameloblastoma with a predilection for the posterior mandibular region is relatively common in our environment.
  • [MeSH-major] Ameloblastoma / epidemiology. Mandibular Neoplasms / epidemiology

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  • (PMID = 16429706.001).
  • [ISSN] 0033-6572
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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20. Miyake T, Tanaka Y, Kato K, Tanaka M, Sato Y, Ijiri R, Inayama Y, Ito Y, Aoki S, Kawabe R, Tohnai I: Gene mutation analysis and immunohistochemical study of beta-catenin in odontogenic tumors. Pathol Int; 2006 Dec;56(12):732-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Six ameloblastomas (five follicular ameloblastomas and one plexiform ameloblastoma) and three malignant odontogenic tumors (one metastasizing ameloblastoma, one ameloblastic carcinoma, and one primary intraosseous odontogenic carcinoma) were investigated for CTNNB1 expression and CTNNB1 mutation.
  • Immunohistochemically, all follicular ameloblastomas and one primary intraosseous odontogenic carcinoma exhibited focal and moderate nuclear/cytoplasmic expression of CTNNB1, whereas the plexiform ameloblastoma and the remaining two malignant odontogenic tumors had entirely membranous expression.
  • The other five follicular ameloblastomas, the plexiform ameloblastoma, and the three malignant odontogenic tumors did not show mutation in exon 3 of CTNNB1.
  • These findings further confirmed that CTNNB1 mutation is not frequent in ameloblastoma and malignant odontogenic tumors, although the abnormality of Wnt signaling may be associated with some of these tumors.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / genetics. Ameloblastoma / pathology. Base Sequence. Child. DNA Mutational Analysis. Female. Humans. Immunohistochemistry. Male. Middle Aged. Molecular Sequence Data. Polymerase Chain Reaction

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  • (PMID = 17096730.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / beta Catenin
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21. Hayes MI, Prince SE: Peripheral ameloblastoma: a case report. Dent Update; 2006 Dec;33(10):624-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral ameloblastoma: a case report.
  • Peripheral ameloblastoma is an uncommon pathological variant of the more usual intraosseous central ameloblastoma.
  • In this paper, a 43-year-old male presented with a three-year history of a painful, slowly enlarging gingival swelling.
  • There was no evidence of bony involvement on radiographs but it was revealed histologically to be a peripheral ameloblastoma.
  • Long-term follow-up is imperative owing to possible recurrence and malignant potential.
  • [MeSH-major] Ameloblastoma / diagnosis. Gingival Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Gingival Diseases / diagnosis. Granuloma, Giant Cell / diagnosis. Humans. Male

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  • (PMID = 17209538.001).
  • [ISSN] 0305-5000
  • [Journal-full-title] Dental update
  • [ISO-abbreviation] Dent Update
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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22. Vayvada H, Mola F, Menderes A, Yilmaz M: Surgical management of ameloblastoma in the mandible: Segmental mandibulectomy and immediate reconstruction with free fibula or deep circumflex iliac artery flap (evaluation of the long-term esthetic and functional results). J Oral Maxillofac Surg; 2006 Oct;64(10):1532-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of ameloblastoma in the mandible: Segmental mandibulectomy and immediate reconstruction with free fibula or deep circumflex iliac artery flap (evaluation of the long-term esthetic and functional results).
  • PURPOSE: Ameloblastoma is responsible for 1% of all the oral and maxillomandibular cysts and tumors.
  • It is odontogenic in origin and benign in nature but it has a high percentage of local recurrence rate and possible malignant development when treated inadequately.
  • With the advancement of craniofacial surgical techniques, use of free flaps for mandibular reconstruction, and dental rehabilitation (such as osseointegration), the segmental mandibulectomy and immediate reconstruction with free flaps are beginning to be used more effectively for the treatment of the mandibular ameloblastoma.
  • The aim of this article is to evaluate the clinical results of the patients with mandibular ameloblastoma who were treated with segmental mandibulectomy and immediate reconstruction with free flaps.
  • PATIENTS AND METHODS: We present 11 patients who had segmental mandibulectomy and immediate reconstruction with free deep circumflex iliac artery or fibular flap for treatment of mandibular ameloblastoma.
  • The functional and esthetic results were also evaluated by using a questionnaire in the long term.
  • CONCLUSIONS: We experienced that segmental mandibulectomy with safe borders and immediate reconstruction with free fibula flap or deep circumflex iliac artery (DCIA) flap is an ideal treatment method for mandibular ameloblastoma.
  • [MeSH-major] Ameloblastoma / surgery. Mandible / surgery. Mandibular Neoplasms / surgery. Oral Surgical Procedures. Surgical Flaps

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  • (PMID = 16982313.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Karakida K, Aoki T, Sakamoto H, Takahashi M, Akamatsu T, Ogura G, Sekido Y, Ota Y: Ameloblastic carcinoma, secondary type: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Dec;110(6):e33-7
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  • Malignant variants of ameloblastoma include metastasizing ameloblastoma, which microscopically appears benign but has metastasized and ameloblastic carcinoma that exhibits malignant histopathologic features.
  • Ameloblastic carcinoma is classified into 2 types: a primary odontogenic malignancy and a secondary type resulting from malignant transformation of ameloblastoma.
  • Most secondary ameloblastic carcinomas result from malignant transformation of a primary lesion after repeated postsurgical recurrences.
  • Therefore it is rare to find an untreated secondary type presenting with histologic features of malignant transformation from an earlier benign lesion.
  • We experienced a rare case of ameloblastic carcinoma, secondary type which might arise in an untreated ameloblastoma.
  • The mechanism by which a preexisting benign ameloblastoma goes through a malignant transformation is also described.
  • [MeSH-major] Ameloblastoma / pathology. Cell Transformation, Neoplastic / pathology. Mandibular Neoplasms / pathology. Odontogenic Tumors / pathology

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  • [Copyright] Crown Copyright © 2010. Published by Mosby, Inc. All rights reserved.
  • (PMID = 21112523.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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24. Zhong M, Liu J, Gong YB, Liu JD, Wang J, Zhang B: [Expression of p21WAF1, p27KIP1 and cyclin E in ameloblastoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jul;40(4):306-9
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  • [Title] [Expression of p21WAF1, p27KIP1 and cyclin E in ameloblastoma].
  • OBJECTIVE: To investigate the expression of cyclin E mRNA, p21(WAF1) mRNA and p27(KIP1) protein in human ameloblastoma (AB), and to explore the clinical and biological characteristics of AB.
  • The expression of cyclin E mRNA increased with AB recurrence and malignant transformation, and the difference of expression among primary AB, recurrent AB, and malignant AB, was statistically significant.
  • [MeSH-major] Ameloblastoma / metabolism. Cyclin E / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Intracellular Signaling Peptides and Proteins / metabolism. Jaw Neoplasms / metabolism. Oncogene Proteins / metabolism

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  • (PMID = 16191374.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CCNE1 protein, human; 0 / CDKN1A protein, human; 0 / CDKN1B protein, human; 0 / Cyclin E; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Intracellular Signaling Peptides and Proteins; 0 / Oncogene Proteins; 0 / RNA, Messenger; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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25. Hertog D, van der Waal I: Ameloblastoma of the jaws: a critical reappraisal based on a 40-years single institution experience. Oral Oncol; 2010 Jan;46(1):61-4
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  • [Title] Ameloblastoma of the jaws: a critical reappraisal based on a 40-years single institution experience.
  • The 40-years of experience in a single institution with the treatment of previously untreated ameloblastoma have been reported, followed by a management protocol.
  • In 11 patients, a preoperative diagnosis of ameloblastoma was available.
  • In the remaining 14 patients the diagnosis of ameloblastoma was a postoperative one.
  • In one of the patients with a recurrence a cervical lymph node metastasis was detected at the same time, resulting in a diagnosis of metastasizing ameloblastoma.
  • [MeSH-major] Ameloblastoma / pathology. Jaw / pathology. Jaw Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 20004134.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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26. Essaadi M, Sif A, Benzaouia A, Rouadi S, Abada RL, Mahtar M, Roubal M, Janah A, Kadiri F, Rifki A: [Recurrent ameloblastoma on a rib graft after 33 years (a case report and review of the literature)]. Rev Laryngol Otol Rhinol (Bord); 2010;131(4-5):303-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent ameloblastoma on a rib graft after 33 years (a case report and review of the literature)].
  • [Transliterated title] Récidive d'un améloblastome sur greffe costale après 33 ans (à propos d'un cas et revue de la littérature).
  • INTRODUCTION: The recurrence of an ameloblastoma is generally due to insufficient margins of resection or to the aggressiveness of the tumour which is regarded as locally malignant.
  • We report the case of a recurrent ameloblastoma on autologus rib graft which occurred 33 years after the surgery.
  • OBSERVATION: A 59 year old man, underwent at the age of 26 years a tumoral removal of a left mandibular cyst with reconstruction by costal graft.
  • The histopathologic diagnosis was an ameloblastoma with healthy limits and without invasion of the soft tissues.
  • CONCLUSION: The pathogenesis of the recurrence of an ameloblastoma on autologus osseous graft is still not well understood.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Ribs / transplantation

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  • (PMID = 21866745.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
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27. Zhong M, Wang J, Gong YB, Li JC, Zhang B, Hou L: [Expression of HOXC13 in ameloblastoma]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Jan;42(1):43-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of HOXC13 in ameloblastoma].
  • OBJECTIVE: To study the expression of HOXC13 mRNA in ameloblastoma (AB), and to investigate its biological significance.
  • METHODS: HOXC13 mRNA was examined in 47 cases of AB (primary AB 29 cases, recurrent AB 14 cases, malignant AB 4 cases).
  • [MeSH-major] Ameloblastoma / genetics. Homeodomain Proteins / metabolism

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  • (PMID = 17331444.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / HOXC13 protein, human; 0 / Homeodomain Proteins; 0 / RNA, Messenger
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28. Tincani AJ, Del Negro A, Araújo PP, Akashi HK, Neves Fda S, Martins AS: Head and neck reconstruction using infrahyoid myocutaneous flaps. Sao Paulo Med J; 2006 Sep 7;124(5):271-4
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  • Here we describe our experience with infrahyoid flaps (IHFs) employed to cover surgical defects in the oral cavity and oropharynx in patients with benign and malignant tumors.
  • Thirteen patients (92.8%) had squamous cell carcinoma (SCC) and one (7.2%) ameloblastoma.

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  • (PMID = 17262158.001).
  • [ISSN] 1516-3180
  • [Journal-full-title] São Paulo medical journal = Revista paulista de medicina
  • [ISO-abbreviation] Sao Paulo Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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29. Kumamoto H, Ooya K: Immunohistochemical detection of phosphorylated Akt, PI3K, and PTEN in ameloblastic tumors. Oral Dis; 2007 Sep;13(5):461-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: 11 tooth germs, 40 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with antibodies against pAkt, PI3K, and PTEN.
  • [MeSH-major] Ameloblastoma / chemistry. Jaw Neoplasms / chemistry. Membrane Proteins / analysis. Oncogene Protein v-akt / analysis. PTEN Phosphohydrolase / analysis

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  • (PMID = 17714348.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Membrane Proteins; EC 2.7.11.1 / Oncogene Protein v-akt; EC 3.1.3.48 / TPTE protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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30. Kamath KP, Vidya M, Shetty N, Karkera BV, Jogi H: Nucleolar organizing regions and alpha-smooth muscle actin expression in a case of ameloblastic carcinoma. Head Neck Pathol; 2010 Jun;4(2):157-62
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  • It is defined as a malignant epithelial odontogenic tumor that histologically has retained the features of ameloblastic differentiation and also exhibits cytologic features of malignancy, like atypia and mitotic activity.
  • Although this lesion represents a separate entity, differentiating it from ameloblastoma has been often challenging to pathologists.
  • In this case study reporting a case of ameloblastic carcinoma, we have attempted to verify the previous findings on the use of Argyrophilic nucleolar organizing regions (AgNORs) and immunohistochemical staining for the alpha-smooth muscle actin (alpha-SMA) in differentiating ameloblastic carcinoma from ameloblastoma.
  • It was observed that AgNORs was found to be almost twice in ameloblastic carcinoma as it was in ameloblastoma.
  • A difference between the two lesions in the pattern of expression of alpha-SMA was also observed, with alpha-SMA being expressed in the odontogenic epithelium and the stroma of ameloblastic carcinoma whereas, in the case of ameloblastoma, it was found only in the stromal part.
  • These findings suggest that AgNORs and alpha-SMA expression may be used as adjuncts to the routine histopathologic examination to differentiate ameloblastic carcinoma and ameloblastoma.
  • [MeSH-major] Actins / metabolism. Ameloblastoma / pathology. Carcinoma / pathology. Mandibular Neoplasms / pathology. Nucleolus Organizer Region / pathology
  • [MeSH-minor] Antigens, Nuclear / analysis. Antigens, Nuclear / genetics. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Mandible / pathology. Mandible / surgery. Middle Aged

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  • [Cites] Micron. 2000 Apr;31(2):117-20 [10588056.001]
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  • (PMID = 20333560.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ACTA2 protein, human; 0 / Actins; 0 / Antigens, Nuclear; 0 / Biomarkers, Tumor; 0 / nucleolar organizer region associated proteins
  • [Other-IDs] NLM/ PMC2878627
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31. Ohtsuru M: Expression of parathyroid hormone-related protein in ameloblastomas. Tokai J Exp Clin Med; 2005 Dec;30(4):233-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Parathyroid hormone-related protein (PTHrP) was first discovered as a causative protein for hypercalcemia, which is often seen in the malignant tumor.
  • The present study, therefore, sought to clarify the expression of PTHrP, parathyroid hormone (PTH) and PTH1R in ameloblastoma, using RT-PCR (N = 8), immunohistochemistry (N = 23) and ELISA (N = 11) techniques.
  • Expression of PTHrP was also seen in all of the 23 cases in ameloblastoma by immunohistochemistry.
  • PTH1R was observed on osteoblasts in bone around the tumor but no expression was observed on ameloblastoma cells in tumor parenchyma by immunohistochemistry.
  • PTH was not detected in ameloblastoma by RT-PCR, immunohistochemistory as well as ELISA.
  • It was suggested that PTHrP level may be associated with local bone infiltration and hypercalcemia in ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Ameloblastoma / metabolism. Jaw Neoplasms / genetics. Jaw Neoplasms / metabolism. Parathyroid Hormone-Related Protein / genetics. Parathyroid Hormone-Related Protein / metabolism

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  • (PMID = 16482944.001).
  • [ISSN] 0385-0005
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / PTH1R protein, human; 0 / Parathyroid Hormone; 0 / Parathyroid Hormone-Related Protein; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptor, Parathyroid Hormone, Type 1; 0 / Receptors, Parathyroid Hormone; SY7Q814VUP / Calcium
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32. Yuan XP, Xie BK, Lin XF, Liang BL, Zhang F, Li JT: [Value of multi-slice spiral CT with three-dimensional reconstruction in the diagnosis of neoplastic lesions in the jawbones]. Nan Fang Yi Ke Da Xue Xue Bao; 2008 Aug;28(9):1700-2, 1706
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Value of multi-slice spiral CT with three-dimensional reconstruction in the diagnosis of neoplastic lesions in the jawbones].
  • OBJECTIVE: To assess the value of multi-slice spiral CT (MSCT) with three dimensional (3D) reconstruction in the diagnosis of neoplastic lesions in the jawbones.
  • Of these patients, 14 had ameloblastoma, 8 had hemangioma, 3 had osteosarcoma, 3 had ossifying fibroma, 2 had chondrosarcoma, 2 had fibrosarcoma, and 1 had odontogenic myxoma.
  • Two-dimensional imaging allowed better observation than 3D imaging of the deep structures, whereas 3D imaging was superior in visualizing the morphological changes of the compromised bones and the spatial relationship between the tumors and surrounding structures.
  • Benign tumors were most visualized as bone expansion changes with well defined ovoid or lobulated borderlines, and malignant ones often resulted in adjacent bony destruction and soft tissue masses.
  • CONCLUSION: MSCT examination is useful in defining the scope of tumor involvement and bony changes to help in the definite diagnosis, differential diagnosis and choice of clinical treatment.
  • [MeSH-major] Imaging, Three-Dimensional / methods. Jaw / radiography. Jaw Neoplasms / diagnosis. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adolescent. Adult. Ameloblastoma / diagnosis. Female. Hemangioma / diagnosis. Humans. Male. Middle Aged. Reproducibility of Results. Sensitivity and Specificity. Young Adult

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  • (PMID = 18819902.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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33. Niu CH, Li TJ: [Mutation and polymorphism of the ameloblastin gene in ameloblastomas]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2006 Nov;41(11):678-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Genomic DNA was extracted from frozen tissues of 10 ameloblastomas and one malignant ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Dental Enamel Proteins / genetics. Jaw Neoplasms / genetics. Polymorphism, Genetic

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  • (PMID = 17331365.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AMBN protein, human; 0 / Dental Enamel Proteins
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34. Sharaf B, Levine JP, Hirsch DL, Bastidas JA, Schiff BA, Garfein ES: Importance of computer-aided design and manufacturing technology in the multidisciplinary approach to head and neck reconstruction. J Craniofac Surg; 2010 Jul;21(4):1277-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The free fibular flap is the standard method for reconstructing large mandibular defects after benign or malignant tumor ablation.
  • [MeSH-major] Ameloblastoma / surgery. Carcinoma, Squamous Cell / surgery. Computer-Aided Design. Head and Neck Neoplasms / surgery. Mandibular Neoplasms / surgery. Surgical Flaps

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  • (PMID = 20613609.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Fiaschetti V, Fanucci E, Rascioni M, Ottria L, Barlattani A, Simonetti G: Jaw expansive lesions: population incidence and CT dentalscan role. Oral Implantol (Rome); 2010 Jul;3(3):2-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: The aim of the study is to evaluate the incidence of different expansive lesions and the advantages of the clinical employment of Dentalscan to study bones lesions and to establish a common diagnostic path.
  • Biopsy for diagnosis was performed on all the lesions, except one (false positive with digital OPT).
  • THE TECHNIQUE SENSITIVITY WAS ASSESSED FOR TWO IMPORTANT CLASSES: benign and malignant lesions.
  • 656 patients (93.1 %) out of 704 examined for a suspicious lesion on the orthopantomography had a benign lesion: (127 follicular cysts (18.2 %), 181 radicular cysts (25.1%), 93 non odontogenic cysts (13.2%), 29 fibroma (4.2%), 198 odontomes (28.2%), 24 ameloblastoma (3.6%), 4 brown tumors (0.7%), 47 (6.9%) had malignant lesions: (12 carcinoma (1.7%), 29 metastasis (4.3%), 6 sarcoma (0.8%), 1 Dentascan CT resulted to be negative (1 false positive of digital OPT).

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  • [Cites] Radiol Clin North Am. 1993 Jan;31(1):163-80 [8419972.001]
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  • (PMID = 23285385.001).
  • [ISSN] 1974-5648
  • [Journal-full-title] ORAL & implantology
  • [ISO-abbreviation] Oral Implantol (Rome)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3399186
  • [Keywords] NOTNLM ; dentalscan / expansive lesions
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36. Fujita S, Hideshima K, Ikeda T: Nestin expression in odontoblasts and odontogenic ectomesenchymal tissue of odontogenic tumours. J Clin Pathol; 2006 Mar;59(3):240-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIMS: The aim of this study was to investigate nestin expression in various odontogenic tumours and evaluate its usefulness for histopathological diagnosis.
  • Although almost all the ameloblastomas and malignant ameloblastomas were negative for nestin, odontogenic ectomesenchyme in the odontogenic mixed tumours demonstrated nestin immunolocalisation, particularly in the region adjacent to the odontogenic epithelium.
  • [MeSH-minor] Adolescent. Adult. Ameloblastoma / chemistry. Female. Fibroma / chemistry. Fibrosarcoma / chemistry. Humans. Immunohistochemistry / methods. Male. Middle Aged. Myxoma / chemistry. Nestin. Odontoblasts / chemistry. Odontogenesis. Odontoma / chemistry. Sensitivity and Specificity

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  • (PMID = 16505272.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / NES protein, human; 0 / Nerve Tissue Proteins; 0 / Nestin
  • [Other-IDs] NLM/ PMC1860355
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37. Ram R: Ameloblastoma relapse after 16 years of resection in symphysis of mandible sparing the bone graft. Natl J Maxillofac Surg; 2010 Jul;1(2):190-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma relapse after 16 years of resection in symphysis of mandible sparing the bone graft.
  • Ameloblastoma is a tumor derived from epithelium involved in odontogenesis.
  • Although it is considered a benign tumor, its clinical behavior may be regarded as lying between benign and malignant.
  • Diagnosis mainly from tissue biopsy and characteristic finding on plain X-rays does assist in differentiating between types of ameloblastoma.

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  • (PMID = 22442598.001).
  • [ISSN] 2229-3418
  • [Journal-full-title] National journal of maxillofacial surgery
  • [ISO-abbreviation] Natl J Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3304200
  • [Keywords] NOTNLM ; Ameloblastoma relapse / epithelial odontogenic tumor / mandibular reconstruction
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38. Akhtar K, Khan N, Zaheer S, Sherwani R, Hasan A: Pindborg tumor in an adolescent. Oman Med J; 2010 Jan;25(1):47-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Calcifying epithelial odontogenic tumour has a much lower recurrence rate than ameloblastoma and malignant transformation, and metastasis is rare.

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  • (PMID = 22125699.001).
  • [ISSN] 2070-5204
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3215391
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39. Bello IO, Alanen K, Slootweg PJ, Salo T: Alpha-smooth muscle actin within epithelial islands is predictive of ameloblastic carcinoma. Oral Oncol; 2009 Sep;45(9):760-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastoma is the most common clinically significant odontogenic tumor.
  • Ameloblastic carcinoma is a malignant tumor having features of ameloblastoma in addition to cytologic atypia with or without metastasis.
  • The aim of this study was to examine which epithelial and stromal markers are predictive of histologically diagnosed ameloblastic carcinoma and can sufficiently differentiate it from solid/multicystic ameloblastoma (SA).
  • [MeSH-major] Ameloblastoma / pathology. Carcinoma / pathology. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Neoplasm Proteins / metabolism

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  • (PMID = 19150605.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / Mucin-1; 0 / Neoplasm Proteins; 0 / calponin
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40. Ladeinde AL, Ajayi OF, Ogunlewe MO, Adeyemo WL, Arotiba GT, Bamgbose BO, Akinwande JA: Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Feb;99(2):191-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY DESIGN: Records of patients seen at the Lagos University Teaching Hospital between January 1980 and December 2003, with histologic diagnosis of odontogenic tumors (based on World Health Organisation classification, 1992), were analyzed.
  • Three hundred and eight (96.6%) were intraosseous, and 11 (3.4%) were peripheral (peripheral odontogenic fibroma=7; peripheral myxoma=3; peripheral ameloblastoma=1).
  • Among these cases, 96.6% of the tumors were benign and 3.4% were malignant.
  • Ameloblastoma with predilection for the mandible was the most frequent odontogenic tumor (63%), followed by adenomatoid odontogenic tumor (AOT) (7.5%), myxoma (6.5%), calcifying epithelial odontogenic cyst (5.3%), and odontogenic fibroma (5.3%).
  • More cases of malignant odontogenic tumors were seen than cases of calcifying epithelial odontogenic tumor and odontomas.
  • The mean ages of patients with AOT, ameloblastic fibroma, and odontoma were significantly lower than those with ameloblastoma ( P<.05).
  • No significant difference was found between the mean ages of patients with benign odontogenic tumors and those with malignant odontogenic tumors ( P=.058).
  • CONCLUSIONS: Odontogenic tumors, especially ameloblastoma, are not considered rare among Nigerians, whereas odontoma, regarded as the most frequent odontogenic tumor in North and South America, is rare.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Child. Child, Preschool. Female. Hospitals, Teaching / statistics & numerical data. Humans. Jaw Neoplasms / epidemiology. Male. Mandibular Neoplasms / epidemiology. Middle Aged. Myxoma / epidemiology. Nigeria / epidemiology. Odontogenic Cyst, Calcifying / epidemiology. Odontoma / epidemiology. Retrospective Studies

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  • (PMID = 15660091.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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41. Ram H, Mohammad S, Husain N, Gupta PN: Ameloblastic carcinoma. J Maxillofac Oral Surg; 2010 Dec;9(4):415-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic carcinoma (AC) is a rare aggressive malignant epithelial odontogenic tumor of the maxillofacial skeleton with a distinct predilection in the mandible.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.
  • It exhibits cytological features of ameloblastoma and carcinoma.

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  • (PMID = 22190836.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177477
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Ameloblastoma / Odontogenic tumor
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42. Jing W, Xuan M, Lin Y, Wu L, Liu L, Zheng X, Tang W, Qiao J, Tian W: Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg; 2007 Jan;36(1):20-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The final diagnosis in each case was based on the WHO 2005 histopathological classification of odontogenic tumours.
  • Of these tumours 1592 (97.0%) were benign and 50 (3.0%) were malignant.
  • Ameloblastoma (40.3%) was the most frequent type, followed by keratocystic odontogenic tumour (35.8%), odontoma (4.7%) and odontogenic myxoma (4.6%).
  • Ameloblastoma and keratocystic odontogenic tumours, important indications of extensive surgical procedures, are not considered rare in this Chinese population, whereas odontoma is uncommon.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Ameloblastoma / pathology. Child. Child, Preschool. China / epidemiology. Female. Humans. Male. Middle Aged. Retrospective Studies. Sex Ratio

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  • (PMID = 17156974.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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43. Adebayo ET, Ajike SO, Adekeye EO: A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg; 2005 Jun;63(6):811-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Twelve histopathologic types of odontogenic tumors were found with more benign (n=314; 99%) than malignant (n=4; 1%).
  • Ameloblastoma made up 233 (73%) of the tumors, followed by odontogenic myxoma (n=38; 12%), ameloblastic fibroma (n=9; 3%), and the adenomatoid odontogenic tumor (2%).
  • Three cases of calcifying odontogenic cyst were co-existent with ameloblastoma (2) and ameloblastic fibro-odontoma (1).
  • At least 8 cases of ameloblastoma (13%) recurred out of 60 followed up.
  • CONCLUSION: Ameloblastoma is a fairly common tumor of Nigerian Africans accounting for 73% of odontogenic tumors and 24% of all tumors and tumor-like lesions of the oral and perioral structures.
  • A minimum of 5 years of follow-up reviews are necessary after treatment of ameloblastoma.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Ameloblastoma / epidemiology. Ameloblastoma / pathology. Child. Female. Fibroma / epidemiology. Fibroma / pathology. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local. Nigeria / epidemiology. Odontogenic Cyst, Calcifying / epidemiology. Odontogenic Cyst, Calcifying / pathology. Retrospective Studies. Surveys and Questionnaires

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  • [ErratumIn] J Oral Maxillofac Surg. 2005 Dec;63(12):1786
  • (PMID = 15944979.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Aregbesola SB, Ugboko VI, Akinwande JA, Arole GF, Fagade OO: Orofacial tumours in suburban Nigerian children and adolescents. Br J Oral Maxillofac Surg; 2005 Jun;43(3):226-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of the 146 tumours 74 (51%) were malignant and 72 (49%) were benign.
  • The most common benign soft tissue and jaw tumours were gingival epulis and ameloblastoma respectively.
  • Of the malignant tumours 67 were lymphomas, 5 sarcomas and 2 carcinomas.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Ameloblastoma / epidemiology. Burkitt Lymphoma / epidemiology. Carcinoma / epidemiology. Child. Child, Preschool. Female. Fibrous Dysplasia of Bone / epidemiology. Gingival Diseases / epidemiology. Hemangioma / epidemiology. Humans. Infant. Infant, Newborn. Jaw Diseases / epidemiology. Jaw Neoplasms / epidemiology. Male. Nigeria / epidemiology. Odontogenic Tumors / epidemiology. Retrospective Studies. Sarcoma / epidemiology

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  • (PMID = 15888358.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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45. Luo HY, Li TJ: Odontogenic tumors: a study of 1309 cases in a Chinese population. Oral Oncol; 2009 Aug;45(8):706-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diagnosis of each case was confirmed according to the WHO histological classification for OTs published in 2005.
  • Of the 1309 OTs, 94.04% were benign and 5.06% were malignant.
  • The most frequent benign tumor was keratocystic odontogenic tumor (38.73%), followed by ameloblastoma (36.52%) and odontomas (6.11%).
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Child. Child, Preschool. China / epidemiology. Female. Humans. Infant. Male. Mandibular Diseases / epidemiology. Maxillary Diseases / epidemiology. Middle Aged. Odontogenic Cysts / epidemiology. Odontoma / epidemiology. Prevalence. Young Adult

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  • (PMID = 19147397.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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46. Kumamoto H, Ooya K: Immunohistochemical detection of BH3-only proteins in ameloblastic tumors. Oral Dis; 2008 Sep;14(6):550-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Nine tooth germs, 37 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with antibodies against Bid, Bim, Bad, Noxa, and Puma.
  • Distinctive expression patterns of these BH3-only proteins in ameloblastoma variants suggest that the BH3-only proteins might be involved in tumor cell differentiation of ameloblastomas.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis Regulatory Proteins / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis

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  • (PMID = 18826384.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BAD protein, human; 0 / BBC3 protein, human; 0 / BH3 Interacting Domain Death Agonist Protein; 0 / BID protein, human; 0 / Bcl-2-like protein 11; 0 / Membrane Proteins; 0 / PMAIP1 protein, human; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-Associated Death Protein; 68238-35-7 / Keratins
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47. Dimba EA, Gichana J, Limo AK, Wakoli KA, Chindia ML, Awange DO: An audit of oral diseases at a Nairobi centre, 2000-2004. Int Dent J; 2007 Dec;57(6):439-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The most common benign tumour was the ameloblastoma (50.23%: n = 109), which predominantly affected the mandible, and also occurred in male patients at a younger age (p = 0.023).
  • Peak incidences for malignant disease were observed in the sixth decade (mean age +/- SD = 46.94 +/- 18.99 years).
  • Oral squamous cell carcinoma (OSCC) was the most common malignant tumour (59.55%; n = 187); occurring in the tongue, floor of the mouth, buccal mucosa and palate.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Child. Child, Preschool. Cysts / epidemiology. Female. Humans. Hyperplasia / epidemiology. Incidence. Infant. Infant, Newborn. Kenya / epidemiology. Male. Middle Aged. Mouth Neoplasms / epidemiology. Retrospective Studies. Sex Distribution

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  • (PMID = 18265777.001).
  • [ISSN] 0020-6539
  • [Journal-full-title] International dental journal
  • [ISO-abbreviation] Int Dent J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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48. Kumamoto H, Ooya K: Immunohistochemical detection of retinoblastoma protein and E2 promoter-binding factor-1 in ameloblastomas. J Oral Pathol Med; 2006 Mar;35(3):183-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against RB, E2F-1, and phosphorylated RB.
  • RESULTS: Immunohistochemical reactivity for RB, E2F-1, phosphorylated RB, and Ki-67 was detected in the nuclei of odontogenic epithelial cells near the basement membrane in tooth germs and benign and malignant ameloblastomas.
  • The levels of immunoreactivity for RB, E2F-1, phosphorylated RB, and Ki-67 were slightly higher in benign and malignant ameloblastomas than in tooth germs.
  • Ki-67 immunoreactivity was significantly higher in ameloblastic carcinomas than in metastasizing ameloblastomas.
  • [MeSH-major] Ameloblastoma / chemistry. E2F1 Transcription Factor / analysis. Retinoblastoma Protein / analysis

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  • (PMID = 16454815.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / E2F1 Transcription Factor; 0 / Ki-67 Antigen; 0 / Retinoblastoma Protein
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49. Jindal C, Palaskar S, Kaur H, Shankari M: Low-grade spindle-cell ameloblastic carcinoma: report of an unusual case with immunohistochemical findings and review of the literature. Curr Oncol; 2010 Oct;17(5):52-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Here, we report a case of low-grade spindle-cell ameloblastic carcinoma arising in pre-existing unicystic ameloblastoma.The patient, a 60-year-old Indian woman, had a large irregular swelling in the left mandibular region.
  • Histologically, the lesion was composed of a large cystic cavity with an ameloblastomatous lining and areas showing spindle-cell proliferation.
  • To our knowledge, 6 cases of spindle-cell ameloblastic carcinoma have been published to date, and this case appears to be the first reporting malignant transformation with spindle-cell differentiation in unicystic ameloblastoma.

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  • (PMID = 20975879.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2949371
  • [Keywords] NOTNLM ; Spindle cells / ameloblastic carcinoma
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50. Benlyazid A, Lacroix-Triki M, Aziza R, Gomez-Brouchet A, Guichard M, Sarini J: Ameloblastic carcinoma of the maxilla: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Dec;104(6):e17-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fifteen patients died with metastatic spread in the lung, brain, or bones; the others were due to a local recurrence.
  • CONCLUSION: Ameloblastic carcinoma is a rare entity of odontogenic tumors that exhibits malignant histologic features in the primary site.
  • [MeSH-major] Ameloblastoma / pathology. Maxillary Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Jaw, Edentulous / pathology. Jaw, Edentulous / radiography. Jaw, Edentulous / surgery. Male. Survival Analysis

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  • (PMID = 17942338.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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51. Chen Y, Wang JM, Li TJ: Ameloblastic fibroma: a review of published studies with special reference to its nature and biological behavior. Oral Oncol; 2007 Nov;43(10):960-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Malignant transformation is evident in 14 recurrent tumors with an overall transformation rate of 11.4%.
  • However, a small number of AFs occurring in childhood may represent the primitive stage of a developing odontoma, as three of the reported recurrent AFs do show further maturation with formation of dental hard tissues.
  • A significantly longer recurrence-free survival was noted in patients treated by radical procedures in comparison to those treated by conservative methods and the age of patients at the first presentation was significantly related to malignant transformation of AF.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology. Odontogenic Tumors / pathology

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  • (PMID = 17689135.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 72
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52. Kumamoto H, Ooya K: Immunohistochemical detection of uPA, uPAR, PAI-1, and maspin in ameloblastic tumors. J Oral Pathol Med; 2007 Sep;36(8):488-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 45 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against uPA, uPAR, PAI-1, and maspin.
  • [MeSH-major] Ameloblastoma / pathology. Enzyme Precursors / analysis. Plasminogen Activator Inhibitor 1 / analysis. Receptors, Cell Surface / analysis. Serine Proteinase Inhibitors / analysis. Serpins / analysis. Urokinase-Type Plasminogen Activator / analysis

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  • (PMID = 17686008.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Enzyme Precursors; 0 / PLAUR protein, human; 0 / Plasminogen Activator Inhibitor 1; 0 / Receptors, Cell Surface; 0 / Receptors, Urokinase Plasminogen Activator; 0 / SERPIN-B5; 0 / Serine Proteinase Inhibitors; 0 / Serpins; EC 3.4.21.73 / Urokinase-Type Plasminogen Activator
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53. Gyulai-Gaál S, Takács D, Barabás J, Tarján I, Martonffy K, Szabó G, Suba Z: [Mixed odontogenic tumors in children and adolescents]. Fogorv Sz; 2007 Apr;100(2):65-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They have a potential to both recurrence and malignant transformation.
  • Early diagnosis and treatment of mixed odontogenic jaw tumors in children may prevent the serious orthodontic complications and jaw deformations.
  • [MeSH-major] Jaw Neoplasms / diagnosis. Jaw Neoplasms / surgery. Odontogenic Tumors / diagnosis. Odontogenic Tumors / surgery. Tooth Eruption, Ectopic / etiology. Tooth, Impacted / etiology
  • [MeSH-minor] Adolescent. Ameloblastoma / diagnosis. Ameloblastoma / surgery. Child. Female. Hamartoma / diagnosis. Hamartoma / surgery. Humans. Male. Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / surgery. Maxillary Neoplasms / diagnosis. Maxillary Neoplasms / surgery. Odontogenic Cysts / diagnosis. Odontogenic Cysts / surgery. Odontoma / diagnosis. Odontoma / surgery. Palatal Neoplasms / diagnosis. Palatal Neoplasms / surgery

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  • (PMID = 17546897.001).
  • [ISSN] 0015-5314
  • [Journal-full-title] Fogorvosi szemle
  • [ISO-abbreviation] Fogorv Sz
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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54. Kumamoto H, Ooya K: Expression of bone morphogenetic proteins and their associated molecules in ameloblastomas and adenomatoid odontogenic tumors. Oral Dis; 2006 Mar;12(2):163-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: Tooth germs, ameloblastomas, adenomatoid odontogenic tumors, and malignant ameloblastomas were examined by RT-PCR and immunohistochemistry for detection of BMP-2, -4, -7, BMP receptors I and II (BMPR-I, BMPR-II), core-binding factor alpha1 (CBFA1), and osterix.
  • [MeSH-major] Ameloblastoma / pathology. Bone Morphogenetic Proteins / analysis. Odontogenic Tumors / pathology

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  • (PMID = 16476038.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / BMP2 protein, human; 0 / BMP4 protein, human; 0 / BMP7 protein, human; 0 / Bone Morphogenetic Protein 2; 0 / Bone Morphogenetic Protein 4; 0 / Bone Morphogenetic Protein 7; 0 / Bone Morphogenetic Proteins; 0 / Core Binding Factor Alpha 1 Subunit; 0 / Sp7 protein, human; 0 / Transcription Factors; 0 / Transforming Growth Factor beta; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type I; EC 2.7.11.30 / Bone Morphogenetic Protein Receptors, Type II
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55. Tawfik MA, Zyada MM: Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Feb;109(2):e67-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY DESIGN: Records of the Oral and Maxillofacial Surgery and Oral Pathology Departments, Faculty of Dentistry, Mansoura University, with histologic diagnosis of odontogenic tumors (based on the World Health Organization classification, 2005), during a 15-year period, were analyzed.
  • Of these, (96.3%) were benign and (3.7%) were malignant.
  • Ameloblastoma (41.5%) was the most frequent type, followed by keratocystic odontogenic tumor (19.5%), odontoma (13.4%), and odontogenic myxoma (8.5%).
  • In Dakahlia, Egypt, ameloblastoma and keratocystic odontogenic tumor are the most frequent odontogenic tumors, with distinct anatomic predilections.

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 19969486.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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56. Kumamoto H, Ohki K: Detection of CD133, Bmi-1, and ABCG2 in ameloblastic tumors. J Oral Pathol Med; 2010 Jan;39(1):87-93

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 12 tooth germs, 47 ameloblastomas, and six malignant ameloblastic tumors were examined using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of CD133, Bmi-1, and ABCG2.
  • Immunohistochemical reactivity for CD133 and Bmi-1 was evident in odontogenic epithelial cells neighboring the basement membrane in tooth germs, ameloblastomas, and metastasizing ameloblastomas, and ameloblastic carcinomas and clear cell odontogenic carcinomas showed reactivity for CD133 and Bmi-1 in most neoplastic cells.
  • The level of CD133 immunoreactivity in malignant ameloblastic tumors was significantly higher than the levels in tooth germs and ameloblastomas.
  • The level of ABCG2 immunoreactivity in malignant ameloblastic tumors was significantly higher than that in tooth germs.
  • Expression of these molecules is possibly involved in oncogenesis, cell differentiation, and malignant potential of odontogenic epithelium.
  • [MeSH-major] ATP-Binding Cassette Transporters / analysis. Ameloblastoma / pathology. Antigens, CD / analysis. Glycoproteins / analysis. Neoplasm Proteins / analysis. Nuclear Proteins / analysis. Peptides / analysis. Proto-Oncogene Proteins / analysis. Repressor Proteins / analysis. Zinc Fingers

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  • (PMID = 19659474.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ABCG2 protein, human; 0 / AC133 antigen; 0 / Antigens, CD; 0 / BMI1 protein, human; 0 / Glycoproteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Peptides; 0 / Proto-Oncogene Proteins; 0 / Repressor Proteins; EC 6.3.2.19 / Polycomb Repressive Complex 1
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57. Zhang L, Chen XM, Sun ZJ, Bian Z, Fan MW, Chen Z: Epithelial expression of SHH signaling pathway in odontogenic tumors. Oral Oncol; 2006 Apr;42(4):398-408

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Recent studies indicate that SHH signaling pathway activation occurs both in the odontogenic cyst and ameloblastoma.
  • Mesenchymal derived odontogenic tumors showed no positive staining except for the focal epithelial cells in island or cord forms within the central portion of the tumor.
  • The protein expression of SHH signaling pathway in malignant odontogenic tumors was no stronger than that in benign tumors.

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  • (PMID = 16376138.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hedgehog Proteins; 0 / Neoplasm Proteins
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58. Parkins GE, Armah G, Ampofo P: Tumours and tumour-like lesions of the lower face at Korle Bu Teaching Hospital, Ghana--an eight year study. World J Surg Oncol; 2007;5:48
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  • BACKGROUND: The oro-facial region including the jawbones, the maxilla and mandible and related tissues can be the site of a multitude of neoplastic conditions.
  • Seventy eight (45.6%) of the patients presented with lesions that were classified as malignant of which 54 (62%) were diagnosed as squamous cell carcinoma (SCC).
  • Fifty-four (62%) of malignant tumours were squamous cell carcinoma; 58 (93.6%) of the benign odontogenic tumours were classified as ameloblastoma.
  • Malignant tumours were more commonly detected in patients between 41 and 70 years (63%).
  • Both malignant and benign tumours are seen in the Ghanaian population.
  • In the present study, SCC and ameloblastoma were the commonest malignant and benign odontogenic tumours seen respectively; the two representing more than 65% of all tumours.

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  • (PMID = 17484780.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1885260
  • [General-notes] NLM/ Original DateCompleted: 20070813
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59. Daneshbod Y, Khademi B, Moemeni B, Seif I, Daneshbod K: Preoperative washing cytology in the diagnosis of maxillary sinus lesions. Acta Cytol; 2010 Mar-Apr;54(2):148-58
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  • [Title] Preoperative washing cytology in the diagnosis of maxillary sinus lesions.
  • STUDY DESIGN: Over a 4-year period, 96 p tients with clinical or radiologic suspicion of a malignant maxillary sinus tumor either confined to the maxillary complex or extending to the nasal cavity underwent preoperative cytologic evaluation by sinus puncture and local washing or nasal washing.
  • RESULTS: There were 47 malignant, 42 benign and 7 borderline cases.
  • Borderline lesions included hemangiopericytoma (4) and ameloblastoma (3).
  • Malignant lesions included squamous cell carcinoma (8), sinonasal adenocarcinoma (2), salivary gland tumors (4), soft tissue tumors (18), malignant melanoma (8) and hematolymphoid neoplasms (7).
  • CONCLUSION: Preoperative sinus washing cytology is a noninvasive and rapid method of diagnosis, with a definite impact on patient surgical planning.
  • [MeSH-major] Cytodiagnosis / methods. Maxillary Sinus / pathology. Neoplasms / diagnosis

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  • (PMID = 20391970.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Yoshida K, Kawase T, Tomita T, Ogawa K, Kawana H, Yago K, Asanami S: Surgical strategy for tumors located in or extending from the intracranial space to the infratemporal fossa-Advantages of the transcranial approach (zygomatic infratemporal fossa approach) and the indications for a combined transcranial and transcervical approach-. Neurol Med Chir (Tokyo); 2009 Dec;49(12):580-6
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  • In five of these 9 cases (2 schwannomas, 1 myxoma, 1 chondrosarcoma, and 1 malignant peripheral nerve sheath tumor), the tumors were localized in the infratemporal fossa, and in the other 4 cases (2 meningiomas, 1 glioblastoma, and 1 ameloblastoma), the tumors extended to both the intracranial space and the infratemporal fossa.

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  • (PMID = 20035132.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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61. Adeline VL, Dimba EA, Wakoli KA, Njiru AK, Awange DO, Onyango JF, Chindia ML: Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit. J Craniofac Surg; 2008 Nov;19(6):1589-93

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  • [Title] Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit.
  • One hundred fifty-three ameloblastomas (83.2%) were of the solid/multicystic subtype; 8 (5.3%) were unicystic; 1 (0.5%) was of extraosseous origin; 1 (0.5%) was desmoplastic; 9 (6.0%) were malignant, and 12 of the records had no histopathologic pattern specified.
  • [MeSH-major] Ameloblastoma / epidemiology. Jaw Neoplasms / epidemiology. Medical Audit

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  • (PMID = 19098557.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Abada RL, Kadiri F, Tawfik N, Benchakroun N, Bouchbika Z, Chekkoury AI, Benchakroun Y, Benider A: [Multiple metastases of a mandibular ameloblastoma]. Rev Stomatol Chir Maxillofac; 2005 Jun;106(3):177-80

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  • [Title] [Multiple metastases of a mandibular ameloblastoma].
  • INTRODUCTION: Ameloblastoma is a benign odontogenic tumor which can be locally aggressive and invasive.
  • Metastases are rare but possible and must be considered as a malignant form of the tumor.
  • OBSERVATION: A 50-year-old woman presented a jugal metastasis of a mandibular ameloblastom which had been treated several times 28 years earlier.
  • The time to development of a metastasis is generally very long and metastases usually remain asymptomatic.
  • [MeSH-major] Ameloblastoma / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 15976707.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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63. Tao Q, Lv B, Qiao B, Zheng CQ, Chen ZF: Immortalization of ameloblastoma cells via reactivation of telomerase function: Phenotypic and molecular characteristics. Oral Oncol; 2009 Dec;45(12):e239-44
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  • [Title] Immortalization of ameloblastoma cells via reactivation of telomerase function: Phenotypic and molecular characteristics.
  • Ameloblastoma (AM) is recognized as a benign tumour but locally invasive with a high risk of recurrence.
  • Also, there was no evidence indicating that the hTERT(+)-AM cells underwent malignant transformation by the nude mouse tumorigenicity assay.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology. Neoplasm Proteins / metabolism. Telomerase / metabolism

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  • (PMID = 19833545.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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64. Parkins GE, Armah GA, Tettey Y: Orofacial tumours and tumour-like lesions in Ghana: a 6-year prospective study. Br J Oral Maxillofac Surg; 2009 Oct;47(7):550-4
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  • Both malignant and benign tumours were recorded and were more common among men (99/182, 54%) in whom they were seen most often between the ages of 41 and 70 years.
  • A total of 108 tumours were diagnosed as malignant (59%), 27 (15%) as benign odontogenic tumours, and 47 (26%) as benign non-odontogenic and tumour-like lesions.
  • Malignant tumours were usually detected in men between the ages of 41 and 70 years (43% of all men); whilst benign tumours were evenly distributed between the sexes with more among girls in the 11-20 year age group.
  • The most common malignant tumours were squamous cell carcinoma (SCC), (69/108, 64%) and lymphomas (18/108, 17%).
  • The predominant benign odontogenic and non-odontogenic tumours were ameloblastoma and fibro-osseous lesions, respectively.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Carcinoma, Squamous Cell / epidemiology. Child. Child, Preschool. Female. Follow-Up Studies. Ghana / epidemiology. Humans. Lymphoma / epidemiology. Male. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology. Middle Aged. Odontogenic Tumors / epidemiology. Palatal Neoplasms / epidemiology. Prospective Studies. Sex Factors. Young Adult

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  • (PMID = 19111945.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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65. Gyulai-Gaál S, Takács D, Szabó G, Suba Z: Mixed odontogenic tumors in children and adolescents. J Craniofac Surg; 2007 Nov;18(6):1338-42

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  • They have a potential for both recurrence and malignant transformation.
  • [MeSH-minor] Adolescent. Ameloblastoma / complications. Ameloblastoma / pathology. Child. Female. Fibroma / complications. Fibroma / pathology. Humans. Male. Odontoma / complications. Odontoma / pathology. Tooth Eruption, Ectopic / etiology. Tooth, Impacted / etiology. Tooth, Unerupted / etiology

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  • (PMID = 17993878.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Yoon HJ, Hong SP, Lee JI, Lee SS, Hong SD: Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Dec;108(6):904-13
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  • Five cases arose de novo, whereas 1 case was secondary type of ameloblastic carcinoma.
  • Microscopically, our cases showed malignant cytologic features with some histologic features of ameloblastoma.
  • Malignant cytologic features included nuclear pleomorphism, hyperchromatism, and high mitotic activity (33.3%).
  • Therefore, diagnosis at an early stage and close periodic screening for metastasis are necessary to improve patient prognosis.
  • [MeSH-major] Ameloblastoma / pathology. Carcinoma / pathology. Jaw Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 19800270.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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67. Fujita S, Seki S, Fujiwara M, Ikeda T: Midkine expression correlating with growth activity and tooth morphogenesis in odontogenic tumors. Hum Pathol; 2008 May;39(5):694-700

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  • There was no difference in positive rate and intensity of MK between benign odontogenic tumors and their malignant counterparts.
  • Ameloblastoma showed MK localization in the peripheral columnar cells in budding processes from the parenchyma, which frequently expressed proliferating cell nuclear antigen.
  • MK was also preferentially expressed in keratinized cells in acanthomatous ameloblastoma and keratocystic odontogenic tumor.
  • In odontogenic mixed tumors except for odontoma, intense immunoreactivity to MK was found in epithelial follicles, the surrounding odontogenic ectomesenchymal tissue, and the basement membrane between them.
  • [MeSH-minor] Adolescent. Adult. Aged. Ameloblastoma / pathology. Ameloblastoma / physiopathology. Female. Humans. Male. Middle Aged. Odontoma / pathology. Odontoma / physiopathology

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  • (PMID = 18329695.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MDK protein, human; 0 / Nerve Growth Factors
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68. Kumamoto H, Ooya K: Immunohistochemical detection of insulin-like growth factors, platelet-derived growth factor, and their receptors in ameloblastic tumors. J Oral Pathol Med; 2007 Apr;36(4):198-206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 47 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against IGF-I, IGF-II, IGF-I receptor (IGF-IR), PDGF A-chain, PDGF B-chain, PDGF alpha-receptor, and PDGF beta-receptor.
  • RESULTS: Immunohistochemical reactivity for IGFs, PDGF chains, and their receptors was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and in benign and malignant ameloblastic tumors.
  • Malignant ameloblastic tumors showed higher reactivity for PDGF chains than benign ameloblastomas and higher reactivity for platelet-derived growth factor receptors than tooth germs.
  • Desmoplastic ameloblastomas showed higher expression of IGFs and IGF-IR when compared with other ameloblastoma subtypes.
  • Altered expression of the ligands and receptors in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / metabolism. Insulin-Like Growth Factor I / biosynthesis. Insulin-Like Growth Factor II / biosynthesis. Jaw Neoplasms / metabolism. Platelet-Derived Growth Factor / biosynthesis. Tooth Germ / metabolism

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  • (PMID = 17391297.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / Receptors, Somatomedin; 0 / platelet-derived growth factor A; 67763-96-6 / Insulin-Like Growth Factor I; 67763-97-7 / Insulin-Like Growth Factor II; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
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69. Kruse AL, Zwahlen RA, Grätz KW: New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol; 2009;1:31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The ameloblastic carcinoma is a rare malignant odontogenic tumor which rather occurs in the mandible than in the maxilla.
  • Current classifications do not consider benign histopathological features at the primary and malignant features at the metastatic tumour site.
  • In 54% the primary diagnosis was ameloblastic carcinoma, 34.6% revealed pulmonary metastases, however, only in one patient cervical lymph node metastasis could be found.
  • Whereas two cases did not reveal malignant histopathology at the primary, they revealed malignant features at their metastatic sites.
  • Nineteen of 26 patients (73,1%) were controlled during a median follow-up time of 54,3 months (6 to 156 months); 6 patients died of disease after a median time of 62,7 months (7 to 156 months) after initial diagnosis.
  • CONCLUSION: It is of utmost importance to be aware of that ameloblastomas may be capable to degenerate into a "malignant" disease with recurrence and metastasis.
  • In addition to local long-term control, special attention should be paid to potential pulmonary involvement.
  • [MeSH-major] Ameloblastoma / classification. Maxillary Neoplasms / classification

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  • (PMID = 19674470.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2733136
  • [General-notes] NLM/ Original DateCompleted: 20100629
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70. Kumamoto H, Ooya K: Immunohistochemical detection of platelet-derived endothelial cell growth factor/thymidine phosphorylase and angiopoietins in ameloblastic tumors. J Oral Pathol Med; 2006 Nov;35(10):606-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 11 tooth germs, 44 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against PD-ECGF/TP and angiopoietin-1 and -2.
  • Immunoreactivity for angiopoietin-1 and -2 was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and in benign and malignant ameloblastic tumors.
  • Malignant ameloblastic tumors had decreased angiopoietin-1 reactivity and ameloblastic carcinomas had increased angiopoietin-2 reactivity as compared with the respective levels in tooth germs and ameloblastomas.
  • Altered expression of PD-ECGF/TP and angiopoietins in ameloblastic tumors may be involved in oncogenesis, malignant potential, and tumor cell differentiation.
  • [MeSH-major] Ameloblastoma / chemistry. Angiopoietin-1 / analysis. Angiopoietin-2 / analysis. Jaw Neoplasms / chemistry. Thymidine Phosphorylase / analysis

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  • (PMID = 17032393.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ANGPT1 protein, human; 0 / Angiopoietin-1; 0 / Angiopoietin-2; EC 2.4.2.4 / Thymidine Phosphorylase
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71. Ozlugedik S, Ozcan M, Basturk O, Deren O, Kaptanoglu E, Adanali G, Unal A: Ameloblastic carcinoma arising from anterior skull base. Skull Base; 2005 Nov;15(4):269-72; discussion 273

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic carcinoma (AC) is an aggressive malignant epithelial odontogenic tumor.
  • It may appear de novo or originate from a pre-existing ameloblastoma or odontogenic cyst.

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  • [Cites] Am J Otolaryngol. 2003 Jan-Feb;24(1):64-9 [12579485.001]
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  • [Cites] Oral Surg Oral Med Oral Pathol. 1987 Jan;63(1):78-84 [3468468.001]
  • [Cites] Oral Surg Oral Med Oral Pathol. 1984 Feb;57(2):168-76 [6366686.001]
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  • (PMID = 16648889.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1380266
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72. Kumamoto H, Ohki K, Ooya K: Expression of p63 and p73 in ameloblastomas. J Oral Pathol Med; 2005 Apr;34(4):220-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of nine tooth germs and 48 benign and five malignant ameloblastomas were examined by immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) for the expression of p63 and p73.
  • RESULTS: Immunoreactivity for p63 and p73 was evident in epithelial cells neighboring the basement membrane in developing and neoplastic odontogenic tissues. p63 expression in desmoplastic ameloblastomas was significantly higher than in acanthomatous and granular cell ameloblastomas, and ameloblastic carcinomas showed higher p63 expression than metastasizing ameloblastomas. p73 expression was significantly higher in plexiform ameloblastomas than in follicular ameloblastomas, and basal cell ameloblastomas showed higher p73 expression than granular cell ameloblastomas. mRNA transcripts for Delta Np63 and TAp73 were detected in all developing and neoplastic odontogenic tissues.
  • TAp63 mRNA was expressed in five of eight tooth germs, 16 of 34 ameloblastomas, and one of one malignant ameloblastoma, whereas Delta Np73 mRNA was recognized in one of eight tooth germs, nine of 34 ameloblastomas, and one of one malignant ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Apoptosis / genetics. DNA-Binding Proteins / genetics. Genes, Tumor Suppressor. Nuclear Proteins / genetics. Phosphoproteins / genetics. Trans-Activators / genetics. Tumor Suppressor Proteins / genetics

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  • (PMID = 15752257.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73
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73. Martano M, Damiano S, Restucci B, Paciello O, Russo V, Maiolino P: Nuclear morphometry in canine acanthomatous ameloblastomas and squamous cell carcinomas. Eur J Histochem; 2006 Apr-Jun;50(2):125-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The aim of this study was to evaluate whether morphometrical analysis can be of diagnostic value for canine acanthomatous ameloblastoma.
  • While the NACV values resulted higher in typical acanthomatous ameloblastoma (29,99+/-6,06) than in atypical acanthomatous ameloblastoma (26,74+/-8,84) and similar to those of the SCCs (30,89+/-7,75).
  • These results seem to confirm that acanthomatous ameloblastoma is a malignant or potentially malignant lesion and emphasizes that nuclear morphometry analysis can be an useful diagnostic and prognostic method in canine oral pathology.
  • [MeSH-major] Ameloblastoma / veterinary. Carcinoma, Squamous Cell / veterinary. Cell Nucleus / pathology. Dog Diseases / diagnosis. Gingiva / pathology. Jaw Neoplasms / veterinary

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  • (PMID = 16864123.001).
  • [ISSN] 1121-760X
  • [Journal-full-title] European journal of histochemistry : EJH
  • [ISO-abbreviation] Eur J Histochem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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74. Saghravanian N, Jafarzadeh H, Bashardoost N, Pahlavan N, Shirinbak I: Odontogenic tumors in an Iranian population: a 30-year evaluation. J Oral Sci; 2010 Sep;52(3):391-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Oral and maxillofacial pathology has paramount importance in connecting basic science and clinical features; progress in this field will improve diagnosis and treatment.
  • Malignant transformation was seen in three cases as malignant ameloblastoma (1.8%).
  • The most common tumor was ameloblastoma, followed by odontoma, odontogenic myxoma, and adenomatoid odontogenic tumor.

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  • (PMID = 20881331.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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75. Gupta B, Ponniah I: The pattern of odontogenic tumors in a government teaching hospital in the southern Indian state of Tamil Nadu. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):e32-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastoma with a predilection for posterior mandible was the most frequent odontogenic tumor (67.69%), followed by adenomatoid odontogenic tumor (9%), odontoma (7.77%), and calcifying odontogenic cyst (5.52%).
  • Among the 489 cases, only 15 (3.07%) were malignant.
  • Ameloblastoma formed the single most common tumor of all odontogenic tumors.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Ameloblastoma / epidemiology. Child. Child, Preschool. Female. Hospitals, Public. Hospitals, Teaching. Humans. India / epidemiology. India / ethnology. Male. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology. Middle Aged. Odontogenic Cyst, Calcifying / epidemiology. Odontoma / epidemiology. Population Surveillance. Retrospective Studies. Sex Factors. Young Adult

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20610293.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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76. Kumamoto H, Ooya K: Expression of tumor necrosis factor alpha, TNF-related apoptosis-inducing ligand, and their associated molecules in ameloblastomas. J Oral Pathol Med; 2005 May;34(5):287-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined by reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of TNFalpha, TNF receptor I (TNFRI), TRAIL, TRAIL receptor 1 (TRAIL-R1), TRAIL-R2, caspase-8, and nuclear factor-kappaB (NF-kappaB).
  • Expression of caspase-8 mRNA was identified in six of 33 ameloblastomas, but not in 10 tooth germs or one malignant ameloblastoma.
  • Expression of caspase-8 was found in some neoplastic cells in three of 37 ameloblastomas, but not in 10 tooth germs or five malignant ameloblastomas.
  • [MeSH-major] Ameloblastoma / metabolism. Apoptosis. Jaw Neoplasms / metabolism. Membrane Glycoproteins / biosynthesis. Tumor Necrosis Factor-alpha / biosynthesis

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  • (PMID = 15817072.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Membrane Glycoproteins; 0 / NF-kappa B; 0 / RNA, Messenger; 0 / Receptors, TNF-Related Apoptosis-Inducing Ligand; 0 / Receptors, Tumor Necrosis Factor; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFRSF10A protein, human; 0 / TNFRSF10B protein, human; 0 / TNFSF10 protein, human; 0 / Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; 0 / Tumor Necrosis Factor-alpha; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspases
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77. Fernandes AM, Duarte EC, Pimenta FJ, Souza LN, Santos VR, Mesquita RA, de Aguiar MC: Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Med; 2005 Nov;34(10):583-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We reviewed the achieves of 19 123 specimens from oral pathology laboratory of Universidade Federal de Minas Gerais, from 1954 to 2004.
  • The most frequent tumor was ameloblastoma (45.2%), followed by odontomas (24.91%), and myxomas (9.1%).
  • CONCLUSIONS: Odontogenic tumors are uncommon lesions in this Brazilian population and malignant OTs are very rare.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Brazil / epidemiology. Child. Child, Preschool. Female. Humans. Infant. Male. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology. Middle Aged. Odontogenic Cyst, Calcifying / epidemiology. Odontoma / epidemiology. Retrospective Studies. Sex Factors

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  • (PMID = 16202077.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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78. Nakano K, Siar CH, Tsujigiwa H, Nagatsuka H, Nagai N, Kawakami T: Notch signaling in benign and malignant ameloblastic neoplasms. Eur J Med Res; 2008 Oct 27;13(10):476-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Notch signaling in benign and malignant ameloblastic neoplasms.
  • BACKGROUND: In general, Notch is a representative signal which controls morphosis and differentiation of cells, but its role in human odontogenic neoplasms, especially in ameloblastoma and its malignant counterpart, ameloblastic carcinoma, is not known.
  • METHODS: We examined Notch1 peptide and its gene (mRNA) in an ameloblastoma (case 1: 27-year-old female, right mandibular tumor) and an ameloblastic carcinoma (case 2: 93-year-old female, right mandibular tumor), using immunohistochemistry (IHC) and in situ hybridization (ISH) techniques.
  • CONCLUSIONS: Notch signaling plays some role in cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells of odontogenic neoplasms, including ameloblastoma and ameloblastic carcinoma.
  • [MeSH-major] Ameloblastoma / genetics. Ameloblastoma / metabolism. Mandibular Neoplasms / genetics. Mandibular Neoplasms / metabolism. Receptor, Notch1 / genetics. Receptor, Notch1 / metabolism

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  • (PMID = 19008176.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / NOTCH1 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Receptor, Notch1
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79. Raut D, Khedkar S: Primary intraosseous mucoepidermoid carcinoma of the maxilla: a case report and review of literature. Dentomaxillofac Radiol; 2009 Mar;38(3):163-8
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  • Primary intraosseous mucoepidermoid carcinoma (PIOC) of the jaw bones is an extremely rare malignant salivary gland tumour.
  • [MeSH-minor] Adult. Ameloblastoma / diagnosis. Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Mucins / analysis. Radiography, Bitewing. Radiography, Panoramic. Tomography, X-Ray Computed

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  • (PMID = 19225087.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 25
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80. Kumamoto H, Ooya K: Immunohistochemical detection of phosphorylated JNK, p38 MAPK, and ERK5 in ameloblastic tumors. J Oral Pathol Med; 2007 Oct;36(9):543-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Ten tooth germs, 47 ameloblastomas, and 5 malignant ameloblastic tumors were examined immunohistochemically with the antibodies against p-JNK, p-p38 MAPK, and p-ERK5.
  • Expression of p-p38 MAPK was found in epithelial or neoplastic cells in tooth germs and ameloblastic tumors except for two ameloblastomas, and increased expression was found in keratinizing cells of acanthomatous ameloblastomas.
  • The expression level of p-p38 MAPK in ameloblastomas was significantly higher than the levels in tooth germs and malignant ameloblastic tumors.
  • [MeSH-major] Ameloblastoma / enzymology. Jaw Neoplasms / enzymology. Mitogen-Activated Protein Kinases / metabolism. Tooth Germ / enzymology

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  • (PMID = 17850438.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 7; EC 2.7.11.24 / Mitogen-Activated Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases
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81. Kumamoto H, Ooya K: Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. J Oral Pathol Med; 2006 Jul;35(6):345-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 11 tooth germs, 40 ameloblastomas, and five malignant ameloblastic tumors were examined immunohistochemically with the use of antibodies against MT1-MMP, RECK, and EMMPRIN.
  • RESULTS: Immunohistochemical reactivity for MT1-MMP, RECK and EMMPRIN was detected predominantly in odontogenic epithelial cells near the basement membrane in tooth germs and benign and malignant ameloblastic tumors.
  • The level of immunoreactivity for MT1-MMP was slightly higher in benign and malignant ameloblastic tumors than in tooth germs.
  • [MeSH-major] Ameloblastoma / chemistry. Antigens, CD147 / analysis. Jaw Neoplasms / chemistry. Matrix Metalloproteinases / analysis. Membrane Glycoproteins / analysis. Tooth Germ / chemistry

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  • (PMID = 16762015.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / GPI-Linked Proteins; 0 / Membrane Glycoproteins; 0 / RECK protein, human; 136894-56-9 / Antigens, CD147; EC 3.4.24.- / Matrix Metalloproteinases; EC 3.4.24.- / Matrix Metalloproteinases, Membrane-Associated
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82. Gilijamse M, Leemans CR, Winters HA, Schulten EA, van der Waal I: Metastasizing ameloblastoma. Int J Oral Maxillofac Surg; 2007 May;36(5):462-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing ameloblastoma.
  • Here is presented a case of a 26-year-old woman with a recurrent ameloblastoma of the mandible and a metastatic lymph node in the homolateral neck.
  • [MeSH-major] Ameloblastoma / secondary. Lymphatic Metastasis / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17275258.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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83. Lin C, Li J, Lu N: [Analysis of 2161 cases of neoplasm in oral maxillofacial region in Xinjiang]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Sep;45(9):553-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A total of 2161 patients with benign or malignant oral-maxillofacial tumors diagnosed in Department of Dentofacial Surgery of the First Affiliated Hospital of Xinjiang Medical College from 1995 to 2009 were analyzed retrospectively.
  • RESULTS: Of the 2161 cases, 58.49% (1264/2161) was benign tumors, 33.13% (716/2161) malignant tumors, and 8.38% (181/2161) tumor-like lesions.
  • The most common benign tumors were pleomorphic adenoma, hemangioma, papilloma, adenolymphoma and ameloblastoma.
  • Squamous cell carcinoma constituted the majority of the malignant tumors.
  • The most common malignant tumors of salivary gland were adenoid cystic carcinoma.
  • The most common odontogenic tumors was ameloblastoma.
  • The most common sites of malignant tumors were tongue, lip, parotiod gland and buccal mucosa.
  • There was more malignant tumors in Uygur nationality than in Han living in the same region.
  • [MeSH-minor] Adenolymphoma. Adenoma, Pleomorphic. Ameloblastoma. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. China / epidemiology. Face. Humans. Incidence. Mouth Mucosa. Odontogenic Tumors. Retrospective Studies. Salivary Gland Neoplasms

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  • (PMID = 21122451.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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84. Kumamoto H, Ooya K: Immunohistochemical detection of beta-catenin and adenomatous polyposis coli in ameloblastomas. J Oral Pathol Med; 2005 Aug;34(7):401-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 10 tooth germs, 40 benign ameloblastomas, and five malignant ameloblastomas were examined immunohistochemically with the use of antibodies against beta-catenin and APC.
  • Nuclear beta-catenin expression was recognized in nine of 40 ameloblastomas and two of five malignant ameloblastomas, but not in tooth germs.
  • APC was evidently expressed in odontogenic epithelial cells neighboring the basement membrane in tooth germs and ameloblastomas, and the reactivity was significantly lower in benign and malignant ameloblastomas than in tooth germs.
  • Follicular ameloblastomas and acanthomatous ameloblastomas tended to show high nuclear beta-catenin expression and low APC reactivity, as compared with other ameloblastoma variants.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / analysis. Ameloblastoma / chemistry. Cytoskeletal Proteins / analysis. Jaw Neoplasms / chemistry. Trans-Activators / analysis

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  • (PMID = 16011608.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / CTNNB1 protein, human; 0 / CTNNB1 protein, mouse; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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85. Suomalainen A, Hietanen J, Robinson S, Peltola JS: Ameloblastic carcinoma of the mandible resembling odontogenic cyst in a panoramic radiograph. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2006 May;101(5):638-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Most ameloblastic carcinomas are presumed to have arisen de novo, with few cases of malignant transformation of ameloblastoma being apparent.
  • A case is reported of a 21-year-old caucasian female with ameloblastic carcinoma in the left angulus area of the mandible resembling an odontogenic cyst in the panoramic radiograph.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Mandibular Diseases / radiography. Odontogenic Cysts / radiography. Radiography, Panoramic. Tomography, X-Ray Computed

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  • (PMID = 16632277.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Bello IO, Soini Y, Slootweg PJ, Salo T: Claudins 1, 4, 5, 7 and occludin in ameloblastomas and developing human teeth. J Oral Pathol Med; 2007 Jan;36(1):48-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: To analyze the distribution pattern of claudins 1, 4, 5, 7 and occludin in benign and malignant ameloblastomas and developing human teeth.
  • METHODS: Paraffin-embedded tissue specimens of 25 benign and four malignant ameloblastomas and two developing human teeth were examined immunohistochemically using antibodies against claudins 1, 4, 5, 7 and occludin.
  • There were no evident differences in the expression of claudins or occludin neither between different histologic subtypes of ameloblastomas nor between benign or malignant cases.
  • CONCLUSION: There were no clear differences in the expression levels between benign and malignant ameloblastic tumors.
  • [MeSH-major] Ameloblastoma / pathology. Membrane Proteins / analysis. Odontogenesis / physiology. Tight Junctions / pathology. Tooth Germ / pathology

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  • (PMID = 17181742.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / CLDN4 protein, human; 0 / CLDN5 protein, human; 0 / CLDN7 protein, human; 0 / Claudin-1; 0 / Claudin-4; 0 / Claudin-5; 0 / Claudins; 0 / Membrane Proteins; 0 / OCLN protein, human; 0 / Occludin
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87. Kumamoto H, Ooya K: Detection of mitochondria-mediated apoptosis signaling molecules in ameloblastomas. J Oral Pathol Med; 2005 Oct;34(9):565-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Tissue specimens of 12 tooth germs, 41 benign ameloblastomas, and five malignant ameloblastomas were examined by reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry to determine the expression of cytochrome c, apoptotic protease-activating factor-1 (APAF-1), caspase-9, and apoptosis-inducing factor (AIF).
  • Immunoreactivity for cytochrome c in tooth germs was slightly weaker than that in benign and malignant ameloblastomas.
  • Expression of these mitochondrial apoptosis signaling molecules might be involved in oncogenesis, cytodifferentiation, and malignant transformation of odontogenic epithelium.
  • [MeSH-major] Ameloblastoma / pathology. Apoptosis / physiology. Intracellular Signaling Peptides and Proteins / analysis. Mitochondria / physiology. Signal Transduction / physiology

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  • (PMID = 16138896.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / AIFM1 protein, human; 0 / APAF1 protein, human; 0 / Apoptosis Inducing Factor; 0 / Apoptotic Protease-Activating Factor 1; 0 / Flavoproteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Proteins; 9007-43-6 / Cytochromes c; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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88. Peled M, El-Naaj IA, Lipin Y, Ardekian L: The use of free fibular flap for functional mandibular reconstruction. J Oral Maxillofac Surg; 2005 Feb;63(2):220-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: The purpose of this investigation is to document our experience using the free vascularized fibular flap for comprehensive reconstruction of discontinuity defects in the mandible, after combined resections of malignant and aggressive odontogenic tumors, with special emphasis on functional aspect of the reconstruction process.
  • [MeSH-minor] Adolescent. Adult. Aged. Ameloblastoma / rehabilitation. Ameloblastoma / surgery. Bone Transplantation / methods. Carcinoma, Basal Cell / rehabilitation. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / rehabilitation. Carcinoma, Squamous Cell / surgery. Dental Implantation, Endosseous. Dental Prosthesis, Implant-Supported. Female. Fibula / surgery. Graft Survival. Humans. Male. Middle Aged. Osteoradionecrosis / rehabilitation. Osteoradionecrosis / surgery. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Plastic and Cosmetic Surgery.
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  • (PMID = 15690291.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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89. Angiero F, Borloni R, Macchi M, Stefani M: Ameloblastic carcinoma of the maxillary sinus. Anticancer Res; 2008 Nov-Dec;28(6B):3847-54
Genetic Alliance. consumer health - Ameloblastic carcinoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic carcinoma is a very rare malignant odontogenic neoplasm of the mandible and maxilla, accounting for some 66 reported cases.
  • The case of a 68-year-old man who presented a fistula with orosinus communication of 14-year duration that, after anti-aggregant therapy, began bleeding is reported.
  • The initial microscopic evaluation of the biopsy and radiographic findings were consistent with benign peripheral ameloblastoma without cellular atypia and extensive fields of acantomatous pattern, but immunohistochemical investigation found strong positivity for Bcl-2, cytokeratins CAM 5 and 6, and for Ki-67/MIB-1, changing our diagnosis.
  • Cellular features of malignancy in the surgical specimen confirmed the diagnosis of ameloblastic carcinoma.
  • This case of an aggressive ameloblastic carcinoma of the maxillary gingiva that presented with an unusual histological pattern illustrates that these tumors can create a diagnostic challenge that may require extensive surgical sampling and/or removal to establish the diagnosis.
  • [MeSH-major] Ameloblastoma / diagnosis. Maxillary Sinus Neoplasms / diagnosis

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  • (PMID = 19192639.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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90. Olgac V, Koseoglu BG, Aksakalli N: Odontogenic tumours in Istanbul: 527 cases. Br J Oral Maxillofac Surg; 2006 Oct;44(5):386-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Of these 527 tumours, 521 were benign and 6 were malignant.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Ameloblastoma / epidemiology. Child. Child, Preschool. Female. Fibroma, Ossifying / epidemiology. Humans. Male. Middle Aged. Myxoma / epidemiology. Odontoma / epidemiology. Turkey / epidemiology

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  • (PMID = 16182417.001).
  • [ISSN] 0266-4356
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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91. Roy Chowdhury SK, Ramen S, Chattopadhyay PK, Moorchung N, Rajkumar K: Ameloblastic Carcinoma of the mandible. J Maxillofac Oral Surg; 2010 Jun;9(2):198-201

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Odontogenic carcinomas are rare lesions arising from dental embryogenic residues and have been designated by a variety of terms like malignant ameloblastoma, ameloblastic carcinoma, metastatic ameloblastoma or primary intra-alveolar epidermoid carcinoma.
  • Ameloblastic carcinoma combines the histological features of ameloblastoma with cytological atypia, even in the absence of metastasis.
  • The lesion has been reported to arise either from the odontogenic cyst or the ameloblastoma.
  • Majority originate de novo and the remaining are malignant transformation of an ameloblastoma.

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  • (PMID = 22190787.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3244098
  • [Keywords] NOTNLM ; Ameloblastic carcinoma / Odontogenic malignancies
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92. Geha H, Boland FX, Francois A, Tardif A, Peron JM: [Polymorphous low-grade adenocarcinoma of the maxilla simulating an odontogenic cyst]. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):105-7
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Adénocarcinome polymorphe de bas grade du maxillaire simulant un kyste odontogénique.
  • INTRODUCTION: In 1990, the WHO classified Polymorphous Low Grade Adenocarcinoma as a low-grade malignant tumor of the minor salivary glands.
  • The diagnosis was infected odontogenic cyst associated with an impacted canine tooth.
  • Ameloblastoma was suggested on macroscopic findings; nevertheless, the pathologic end diagnosis was Polymorphic Low-Grade Adenocarcinoma of minor salivary gland origin.
  • [MeSH-minor] Cuspid. Diagnosis, Differential. Female. Humans. Middle Aged. Odontogenic Cysts / diagnosis. Tooth, Impacted / complications

  • Genetic Alliance. consumer health - Polymorphous low-grade adenocarcinoma.
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  • (PMID = 20347466.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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93. Naik V, Kale AD: Ameloblastic carcinoma: a case report. Quintessence Int; 2007 Nov-Dec;38(10):873-9
Genetic Alliance. consumer health - Ameloblastic carcinoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic carcinoma is a rare malignant lesion with characteristic histologic features and behavior that dictate a more radical surgical approach than does a simple ameloblastoma.
  • The radiographic appearance of ameloblastic carcinoma is consistent with that of ameloblastoma except for occasional presence of some focal radiopacities, apparently reflecting dystrophic calcification.
  • Histologically, the tumor cells resemble cells seen in ameloblastoma but show cytologic atypia, cellular pleomorphism, nuclear hyperchromatism, mitoses, and vascular and neural invasion.
  • It is probable that ameloblastoma, like other tumors (such as carcinoid tumors and epithelial tumors of the ovary), shows a spectrum of histologic and biologic behavior ranging from benignity at one end to frank malignancy at the other.
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • (PMID = 18197328.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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94. Pontes HA, Pontes FS, Silva BS, Cury SE, Fonseca FP, Salim RA, Pinto Júnior Ddos S: Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma. Ann Diagn Pathol; 2010 Dec;14(6):447-52
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic fibrosarcoma (AFS), regarded as the malignant counterpart of the benign ameloblastic fibroma, is an extremely rare odontogenic neoplasm with only 68 cases reported in the English literature up to 2009.
  • It is composed of a benign odontogenic epithelium, resembling that of ameloblastoma, and a malignant mesenchymal part exhibiting features of fibrosarcoma.
  • The results obtained revealed that all the proteins evaluated were overexpressed in the malignant mesenchymal portion of AFS if compared with ameloblastic fibroma, suggesting that nuclear proliferative factors such as Ki67 and proliferative cell nuclear antigen, in association to histopathologic features, may be useful markers for identifying the malignancy and that, despite the lack of molecular analysis in the case reported, Bcl-2 alteration may play a role in AFS pathogenesis.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21074695.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-bcl-2
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95. Devenney-Cakir B, Dunfee B, Subramaniam R, Sundararajan D, Mehra P, Spiegel J, Sakai O: Ameloblastic carcinoma of the mandible with metastasis to the skull and lung: advanced imaging appearance including computed tomography, magnetic resonance imaging and positron emission tomography computed tomography. Dentomaxillofac Radiol; 2010 Oct;39(7):449-53
Genetic Alliance. consumer health - Ameloblastic carcinoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ameloblastic carcinoma is a very rare malignant odontogenic tumour with characteristic histopathological and clinical features, which requires aggressive surgical treatment and surveillance and, therefore, differs from ameloblastoma.

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  • (PMID = 20841465.001).
  • [ISSN] 0250-832X
  • [Journal-full-title] Dento maxillo facial radiology
  • [ISO-abbreviation] Dentomaxillofac Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC3520182
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96. Kim K, Velez I, Kaltman SI, Lopez E, Stern D: Odontogenic carcinoma differentiation into rhabdomyosarcoma: report of a rare case. Quintessence Int; 2009 Nov-Dec;40(10):837-42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Odontogenic carcinoma differentiation into rhabdomyosarcoma: report of a rare case.
  • Within the English-language literature, only 2 cases are reported of an odontogenic tumor with muscle differentiation: a benign odontogenic tumor (ameloblastoma) with differentiation into a rhabdomyosarcoma and an odontogenic sarcoma with smooth-muscle differentiation.
  • The general practitioner should be aware that odontogenic lesions may be malignant, even though this is extremely rare, and all tissue removed from the oral cavity should be submitted for biopsy.
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Follow-Up Studies. Gingival Diseases / diagnosis. Granuloma, Giant Cell / diagnosis. Granuloma, Pyogenic / diagnosis. Humans. Male. Maxillary Neoplasms / pathology

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  • (PMID = 19898715.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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97. Kitsoulis P, Charchanti A, Paraskevas G, Marini A, Karatzias G: Adamantinoma. Acta Orthop Belg; 2007 Aug;73(4):425-31
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma.
  • Adamantinoma is one of the rarest low-grade malignant bone tumours, representing less than 1% of them.
  • Fisher in 1913 named this tumour adamantinoma because of its similarity to ameloblastoma of the jaw.
  • It usually arises in the center of long bones, and 97% of all reported cases were in long tubular bones and mainly in the tibial mid shaft (80-85%).
  • Other long bones not uncommonly affected are the humerus, ulna, femur, fibula and radius.
  • Ribs, spine, metatarsal and carpal bones are very rarely affected.
  • Young males are more prone to develop adamantinoma than females.
  • The tumour usually spreads to the lungs, the regional lymph nodes, or other bones.
  • [MeSH-major] Adamantinoma. Bone Neoplasms

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  • (PMID = 17939469.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 58
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98. Kamulegeya A, Kalyanyama BM: Oral maxillofacial neoplasms in an East African population a 10 year retrospective study of 1863 cases using histopathological reports. BMC Oral Health; 2008;8:19

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: In the period between June 1989 and July 1999, 565 and 1298 neoplastic oro-facial cases were retrieved of which 284 (50.53%) and 967 (74.54%) were malignant neoplasms at Muhimbili and Mulago hospitals respectively.
  • Overall 67.28% of the diagnoses recorded were malignant with Kaposi's sarcoma (21.98%), Burkiits lymphoma (20.45%), and squamous cell carcinoma (15.22%) dominating that group while ameloblastoma (9.23%), fibromas (7.3%) and pleomorphic adenoma (4.95%) dominated the benign group.The high frequency of malignancies could be due to inclusion criteria and the clinical practice of selective histopathology investigation.

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  • (PMID = 18651958.001).
  • [ISSN] 1472-6831
  • [Journal-full-title] BMC oral health
  • [ISO-abbreviation] BMC Oral Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2561014
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99. Nguyen BD: Malignant ameloblastoma with thoracic vertebral metastasis: PET/CT and MR imaging. Clin Nucl Med; 2005 Jun;30(6):450-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant ameloblastoma with thoracic vertebral metastasis: PET/CT and MR imaging.
  • [MeSH-major] Ameloblastoma / diagnosis. Ameloblastoma / secondary. Fluorodeoxyglucose F18. Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / secondary. Spinal Neoplasms / diagnosis. Spinal Neoplasms / secondary. Thoracic Vertebrae

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  • (PMID = 15891309.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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100. Zhang Y, Ma XL, Zheng Y: [A case with malignant ameloblastoma of larynx]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 May;43(5):389-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case with malignant ameloblastoma of larynx].
  • [MeSH-major] Ameloblastoma. Laryngeal Neoplasms

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  • (PMID = 18717322.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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