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1. Gonçalves R, Saad Junior R, Dorgan Neto V, Botter M: [A rare case of pneumothorax: metastatic adamantinoma]. J Bras Pneumol; 2008 Jun;34(6):425-9
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  • [Title] [A rare case of pneumothorax: metastatic adamantinoma].
  • [Transliterated title] Caso raro de pneumotórax: adamantinoma metastático.
  • Here, we describe two cases of lung metastasis of adamantinoma of long bones, a low-grade bone neoplasm that rarely metastasizes.
  • In both cases, the clinical presentation of the metastases was characterized by spontaneous pneumothorax secondary to tumor cavitation, a phenomenon described in only three of the studies reviewed in the literature.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Lung Neoplasms / secondary. Pneumothorax / etiology

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  • (PMID = 18622511.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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2. Kanakaraddi SV, Nagaraj G, Ravinath TM: Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation. J Bone Joint Surg Br; 2007 Mar;89(3):388-9
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  • [Title] Adamantinoma of the tibia with late skeletal metastasis: an unusual presentation.
  • Adamantinoma is a rare tumour of long bones that occurs most commonly in the tibia.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Femoral Neoplasms / secondary. Tibia

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  • (PMID = 17356156.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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3. Jain D, Jain VK, Vasishta RK, Ranjan P, Kumar Y: Adamantinoma: a clinicopathological review and update. Diagn Pathol; 2008;3:8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma: a clinicopathological review and update.
  • Adamantinoma is a primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia.
  • The etiology of the tumor is still a matter of debate.
  • The initial symptoms of adamantinoma are often indolent and nonspecific and depend on location and extent of the disease.
  • Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.
  • To assure the histological diagnosis, pathologists should employ immunohistochemistry for demonstrating the sometimes sparse epithelial cell nests when the radiological features are suggestive of adamantinoma.
  • There is paucity of compiled data over adamantinoma in the literature, hence authors tried to make a comprehensive review which must be of use to beginners and trained pathologists.
  • Our objective is to further define the clinicoradiologic features and pathologic spectra of adamantinoma.

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  • (PMID = 18279517.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2276480
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4. Lee RS, Weitzel S, Eastwood DM, Monsell F, Pringle J, Cannon SR, Briggs TW: Osteofibrous dysplasia of the tibia. Is there a need for a radical surgical approach? J Bone Joint Surg Br; 2006 May;88(5):658-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The possible link with adamantinoma is controversial and some authors believe that they are part of one histological process.
  • There were three confirmed cases of adamantinoma.
  • [MeSH-minor] Adamantinoma / pathology. Adamantinoma / radiography. Adamantinoma / surgery. Adolescent. Adult. Child. Child, Preschool. Curettage / methods. Diagnosis, Differential. Female. Fibula / transplantation. Humans. Male. Orthopedic Procedures / methods. Recurrence. Retrospective Studies

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  • [CommentIn] J Bone Joint Surg Br. 2007 Jan;89(1):141 [17259434.001]
  • (PMID = 16645116.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Namba Y, Kimata Y, Koshima I, Sugihara S, Sato T: Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report. Acta Med Okayama; 2006 Aug;60(4):233-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fibular osteoadiposal flap for treatment of tibial adamantinoma: a case report.
  • We treated a case with left tibial adamantinoma by use of a contralateral fibular osteoadiposal flap.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Fibula / surgery. Skin Transplantation. Surgical Flaps. Tibia / surgery

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  • (PMID = 16943861.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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6. Hahn SB, Kim SH, Cho NH, Choi CJ, Kim BS, Kang HJ: Treatment of osteofibrous dysplasia and associated lesions. Yonsei Med J; 2007 Jun 30;48(3):502-10

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To report long term treatment outcomes of osteofibrous dysplasia and association with adamantinoma.
  • After the initial pathology slides of the 13 patients were reviewed with immunohistochemical cytokeratin staining, one patient diagnosis was changed from osteofibrous dysplasia to osteofibrous dysplasia-like adamantinoma.
  • CONCLUSION: Some patients with osteofibrous dysplasia require close observation because of the high association risk between osteofibrous dysplasia and adamantinoma, Immunohistochemical staining may be helpful in differentiating these two diagnoses.
  • [MeSH-major] Adamantinoma / surgery. Fibrous Dysplasia of Bone / surgery

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  • (PMID = 17594160.001).
  • [ISSN] 0513-5796
  • [Journal-full-title] Yonsei medical journal
  • [ISO-abbreviation] Yonsei Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 68238-35-7 / Keratins
  • [Other-IDs] NLM/ PMC2628088
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7. Hatori M, Watanabe M, Hosaka M, Sasano H, Narita M, Kokubun S: A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature. Tohoku J Exp Med; 2006 May;209(1):53-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A classic adamantinoma arising from osteofibrous dysplasia-like adamantinoma in the lower leg: a case report and review of the literature.
  • Adamantinoma is known as a low-grade malignant biphasic tumor.
  • Classic adamantinoma is in general characterized by admixture of both epithelial and osteofibrous components that are associated with various proportions and differentiation patterns.
  • OFD-like adamantinoma is characterized by predominance of osteofibrous tissues, in which small groups of epithelial cells are only detected by careful search or immunohistochemistry.
  • There have been controversies as to the potential correlation among OFD, OFD-like adamantinoma and classic adamantinoma.
  • We report an unusual case of adamantinoma arising in the tibia, with an extensive review of the literature.
  • The present findings suggest a direct correlation between OFD-like adamantinoma and classic adamantinoma.
  • The biopsy lesion was diagnosed as classic adamantinoma.
  • The primary lesion was retrospectively diagnosed as OFD-like adamantinoma because of presence of keratin-positive epithelial cells within the stroma.
  • The retrospective histological findings of OFD-like adamantinoma in the original biopsy and of a classic adamantinoma in all sections of the later resection specimen raised the possibility of an unusual progression of OFD-like adamantinoma to a classic adamantinoma.
  • The present case and the literature review suggest that an OFD-like adamantinoma may be a precursor lesion of classic adamantinoma.
  • Therefore, the possibility of progression of OFD-like adamantinoma to a classic adamantinoma should be kept in mind, particularly when the destructive changes are seen radiologically.
  • [MeSH-major] Adamantinoma / physiopathology. Bone Diseases, Developmental / physiopathology. Leg

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  • (PMID = 16636523.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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8. Dini LI, Mendonça R, Adamy CA, Saraiva GA: Adamantinoma of the Spine: Case Report. Neurosurgery; 2006 Aug 01;59(2):E426

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of the Spine: Case Report.

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  • (PMID = 28180646.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Kitsoulis P, Charchanti A, Paraskevas G, Marini A, Karatzias G: Adamantinoma. Acta Orthop Belg; 2007 Aug;73(4):425-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma.
  • Adamantinoma is one of the rarest low-grade malignant bone tumours, representing less than 1% of them.
  • Fisher in 1913 named this tumour adamantinoma because of its similarity to ameloblastoma of the jaw.
  • Young males are more prone to develop adamantinoma than females.
  • [MeSH-major] Adamantinoma. Bone Neoplasms

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  • (PMID = 17939469.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 58
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10. A J, Kc BR, Basnet SB, Panth R, Shrestha RL, Chand P, Thapa BB: Adamantinoma of tibial shaft. JNMA J Nepal Med Assoc; 2009 Oct-Dec;48(176):331-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of tibial shaft.
  • Adamantinoma is an extremely rare primary bony neoplasm.
  • On the other hand adamantinoma mimics many benign conditions, so it is doubly important to establish correct tissue diagnosis to avoid radical surgery with morbidities.
  • Because of its rarity, diagnosing adamantinoma still remains difficult, even if when it occurs in classical sites.
  • We report a case of adamantinoma of tibial shaft diaphysis in a 23 year male.
  • In this case, because of classic clinic-radiological features, we were suspecting adamantinoma from very beginning but final diagnosis was delayed for nine months.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia

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  • (PMID = 21105562.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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11. Most MJ, Sim FH, Inwards CY: Osteofibrous dysplasia and adamantinoma. J Am Acad Orthop Surg; 2010 Jun;18(6):358-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia and adamantinoma.
  • Adamantinoma (AD) is a rare, low-grade malignant primary bone tumor that occurs most often in the tibia and/or fibula of adolescent persons and young adults; however, it has been reported in other long bones, as well.
  • More recently, published reports have described another clinical entity-differentiated or OFD-like AD-that appears to lie between OFD and AD along a spectrum of disease.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Bone Neoplasms / pathology. Bone Neoplasms / surgery. Fibrous Dysplasia of Bone / pathology. Fibrous Dysplasia of Bone / surgery

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  • (PMID = 20511441.001).
  • [ISSN] 1067-151X
  • [Journal-full-title] The Journal of the American Academy of Orthopaedic Surgeons
  • [ISO-abbreviation] J Am Acad Orthop Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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12. Cappuccio M, Montalti M, Bosco G, Gasbarrini A, Boriani S: Unusual radiographic appearance of adamantinoma. Orthopedics; 2009 Dec;32(12):926
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual radiographic appearance of adamantinoma.
  • Adamantinoma is a rare tumor with an indolent course that occurs most commonly in the tibia.
  • Microscopically, adamantinoma consists of islands of epithelial cells in a fibrous stroma.
  • This tumor most often affects the tibial diaphysis and produces lytic lesions that can cause fractures.
  • Diagnosis of adamantinoma was performed.
  • At 2-year follow-up, there were no clinical or radiological signs of recurrence of disease.
  • [MeSH-major] Adamantinoma / radiography. Adamantinoma / surgery. Bone Neoplasms / radiography. Bone Neoplasms / surgery. Tibia / radiography. Tibia / surgery

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  • [Copyright] Copyright 2009, SLACK Incorporated.
  • (PMID = 19968233.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Roque P, Mankin HJ, Rosenberg A: Adamantinoma: an unusual bone tumour. Chir Organi Mov; 2008 Dec;92(3):149-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma: an unusual bone tumour.
  • Adamantinoma is a rare tumour, which most often affects the tibia and produces lytic and sometimes destructive lesions, which can cause fractures.
  • Only three of the patients died of disease with the time until death ranging from 10 to 17 years.
  • [MeSH-major] Adamantinoma / diagnostic imaging. Adamantinoma / pathology. Bone Neoplasms / diagnostic imaging. Bone Neoplasms / pathology. Tibia / diagnostic imaging. Tibia / pathology

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  • (PMID = 19030952.001).
  • [ISSN] 1973-2538
  • [Journal-full-title] La Chirurgia degli organi di movimento
  • [ISO-abbreviation] Chir Organi Mov
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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14. Dini LI, Mendonça R, Adamy CA, Saraiva GA: Adamantinoma of the spine: case report. Neurosurgery; 2006 Aug;59(2):E426; discussion E426
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  • [Title] Adamantinoma of the spine: case report.
  • OBJECTIVE: We report a patient with a cervicothoracic spinal and a mandibular adamantinoma.
  • Adamantinoma is a rare malignant neoplasm of bone and, to our knowledge, there have been only five cases of spinal adamantinoma reported.
  • The pathogenesis of the adamantinoma, as well as the management of this extremely rare spinal tumor, is reviewed.
  • On a second procedure, posterior tumor resection and spinal stabilization were performed.
  • After the 1-year follow-up examination, a new anterior procedure was performed because of tumor recidivity and spine instability.
  • CONCLUSION: Adamantinoma, an extremely rare lesion, is a locally aggressive tumor with slow growth and the potential to metastasize.
  • Although it is an extremely rare occurrence in the spine, adamantinoma should be considered on the diagnosis of tumors of the vertebrae.
  • Neuroradiological examinations are not specific in the differentiation of this tumor from other conditions.
  • This fact, coupled with the limited experience that most physicians in general have in dealing with this tumor, makes the diagnosis and treatment of adamantinoma challenging.
  • [MeSH-major] Adamantinoma / diagnosis. Cervical Vertebrae / pathology. Radiculopathy / etiology. Spinal Neoplasms / diagnosis

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  • (PMID = 16883154.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Kitsoulis P, Mantellos G, Xenakis T: Adamantinoma of the tibia: local resection and distraction osteogenesis. Acta Chir Belg; 2009 Jan-Feb;109(1):126-9
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  • [Title] Adamantinoma of the tibia: local resection and distraction osteogenesis.
  • We describe a case of adamantinoma of the distal tibia in a 31-year-old woman.
  • [MeSH-major] Adamantinoma / surgery. Bone Neoplasms / surgery. Osteogenesis, Distraction. Tibia

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  • (PMID = 19341216.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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16. Gleason BC, Liegl-Atzwanger B, Kozakewich HP, Connolly S, Gebhardt MC, Fletcher JA, Perez-Atayde AR: Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal. Am J Surg Pathol; 2008 Mar;32(3):363-76
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  • [Title] Osteofibrous dysplasia and adamantinoma in children and adolescents: a clinicopathologic reappraisal.
  • Osteofibrous dysplasia (OFD) and adamantinoma are rare and most commonly arise in the tibia of young individuals.
  • Although OFD has typical histopathologic features, areas resembling OFD have often been noted at the periphery of otherwise classic adamantinomas, and some have suggested that OFD may be either a precursor to or a regressive phase of adamantinoma.
  • The so-called OFD-like adamantinoma encompasses some features of both OFD and adamantinoma.
  • Patients with OFD were generally younger than those with adamantinoma.
  • Osteoblastic and osteoclastic activity was more prominent in OFD than in OFD-like adamantinoma.
  • In addition to the inconspicuous small clusters of epithelial cells in OFD-like adamantinoma, isolated keratin-positive cells with a unique ultrastructural hybrid fibroblastic-epithelial phenotype were found in the stroma of all OFD and OFD-like adamantinomas.
  • Fluorescence in situ hybridization analysis revealed trisomies 7, 8, and/or 12 in the spindle cell stroma of OFD, OFD-like, and classic adamantinoma, supporting a neoplastic origin of OFD and a common histogenesis for all 3 lesions.
  • Of the 11 OFD patients with follow-up (median, 4.5 y), all 3 who underwent incisional biopsy had persistent, nonprogressive disease and 2 of 8 who underwent curettage or wide excision had recurrence; none developed adamantinoma.
  • All 6 adamantinoma patients with follow-up (3 classic and 3 OFD-like) were treated with wide excision.
  • One with classic adamantinoma died of pulmonary metastases 9 years after presentation; the other 5 were free of disease with a median follow-up of 12 years.
  • None of the classic adamantinomas evolved into OFD-like adamantinoma or OFD.
  • Although the histopathology, immunohistochemistry, ultrastructure, and cytogenetics indicate that these lesions are closely related, our data and the literature suggest that only classic adamantinoma has malignant potential.
  • OFD, OFD-like adamantinoma, and classic adamantinoma appear to show a progressive complexity of cytogenetic aberrations, perhaps indicative of a multistep neoplastic transformation.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Fibrous Dysplasia of Bone / pathology

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  • (PMID = 18300815.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Bishop JA, Ali SZ: Primary tibial adamantinoma diagnosed by fine needle aspiration. Diagn Cytopathol; 2010 Mar;38(3):198-201
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  • [Title] Primary tibial adamantinoma diagnosed by fine needle aspiration.
  • Adamantinoma is one of the rarest primary bone tumors and is almost exclusively found in the tibia.
  • Because of its scarcity, there are only a handful of reported cases of adamantinoma diagnosed by fine needle aspiration (FNA).
  • An immunostain for cytokeratin was positive, supporting the diagnosis of adamantinoma.
  • Due primarily to its rarity, the diagnosis of adamantinoma on FNA can be challenging and must be made in the context of its characteristic clinical and radiographic setting.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Bone Transplantation. Female. Humans. Immunohistochemistry. Keratins / analysis

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  • (PMID = 19774617.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 68238-35-7 / Keratins
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18. Van Rijn R, Bras J, Schaap G, van den Berg H, Maas M: Adamantinoma in childhood: report of six cases and review of the literature. Pediatr Radiol; 2006 Oct;36(10):1068-74
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  • [Title] Adamantinoma in childhood: report of six cases and review of the literature.
  • BACKGROUND: Adamantinoma is a rare slow-growing malignant bone tumour.
  • MATERIALS AND METHODS: The database of the Working Group on Paediatric Oncology, Academic Medical Centre/Emma Children's Hospital Amsterdam, was searched for cases of adamantinoma.
  • Additionally a literature study was performed to identify cases of adamantinoma in childhood.
  • RESULTS: We identified six local cases of adamantinoma of the long bones, two boys (age 3 and 8 years) and four girls (mean age 8.8 years, range 3.0-14.0 years).
  • On follow-up (mean 6.1 years, range 1.6-12.0 years) all children remained disease-free.
  • CONCLUSION: Although the incidence of adamantinoma is low, it is important to recognize this rare bone tumour, since in the early stages of the disease adequate treatment will result in an excellent prognosis.
  • [MeSH-major] Adamantinoma / diagnosis

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  • (PMID = 16906392.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 59
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19. Chandrasekar CR, Mohammed R, Rafalla AA, Grimer RJ: Adamantinoma of the calcaneum--a case report. Foot (Edinb); 2009 Mar;19(1):58-61
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  • [Title] Adamantinoma of the calcaneum--a case report.
  • Adamantinoma is rare, representing less than 1% of all primary malignant bone tumours.
  • Adamantinoma commonly occurs in the tibia.
  • Adamantinoma of the foot is extremely rare.
  • To our knowledge adamantinoma of the calcaneum has not been previously reported in the literature.
  • We report the case of a male patient, aged 33 years, who was treated for adamantinoma of the calcaneum and followed for 16 years highlighting the difficulty in diagnosis and management of this rare tumor occurring at a rare site.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Calcaneus / pathology

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  • (PMID = 20307451.001).
  • [ISSN] 1532-2963
  • [Journal-full-title] Foot (Edinburgh, Scotland)
  • [ISO-abbreviation] Foot (Edinb)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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20. Panchwagh Y, Puri A, Agarwal M, Chinoy R, Jambhekar N: Case report: metastatic adamantinoma of the tibia--an unusual presentation. Skeletal Radiol; 2006 Mar;35(3):190-3
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  • [Title] Case report: metastatic adamantinoma of the tibia--an unusual presentation.
  • A 26-year-old female with a tibial lesion diagnosed as an adamantinoma was treated with intra-lesional curettage, bone grafting and intra-medullary nailing.
  • Although cases of local recurrences and pulmonary metastases in adamantinoma are reported, this case is unusual in presenting without a local recurrence but with simultaneous skeletal and pulmonary metastases.
  • [MeSH-major] Adamantinoma / secondary. Bone Neoplasms / pathology. Femoral Neoplasms / secondary. Lung Neoplasms / secondary. Tibia

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  • (PMID = 16402219.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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21. Mathew M, Joseph B: Differentiated adamantinoma: a case report and review of literature. Indian J Pathol Microbiol; 2007 Jul;50(3):565-7
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  • [Title] Differentiated adamantinoma: a case report and review of literature.
  • Adamantinoma of the long bones are uncommon, slow growing tumors with a predilection for the tibia.
  • A special rare variant known as the osteofibrous dysplasia-like adamantinoma or differentiated adamantinoma is thought to be a precursor of the classic adamantinoma.
  • Microscopy showed a tumor composed predominantly of osteofibrous dysplasia-like areas with focal cytokeratin positive epithelial islands.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Tibia / pathology

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  • (PMID = 17883137.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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22. Mavrogenis AF, Galanakos S, Savvidou OD, Papagelopoulos PJ: Adamantinoma of the tibia mimicking a benign cystic lesion: a case report. Clin Podiatr Med Surg; 2010 Jan;27(1):157-65
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  • [Title] Adamantinoma of the tibia mimicking a benign cystic lesion: a case report.
  • Adamantinoma of the long bones is a rare primary malignant bone tumor accounting for less than 1% of all primary malignant bone tumors.
  • In this article, the authors present a case report of a patient with a distal tibia adamantinoma mimicking a benign cystic lesion.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Tibia

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  • (PMID = 19963177.001).
  • [ISSN] 1558-2302
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Flowers R, Baliga M, Guo M, Liu SS: Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings. Acta Cytol; 2006 Sep-Oct;50(5):567-73
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  • [Title] Tibial adamantinoma with local recurrence and pulmonary metastasis: report of a case with histocytologic findings.
  • BACKGROUND: Adamantinoma is a rare primary bone neoplasm of low malignant potential that may recur or metastasize in a mall percentage of patients.
  • The myriad histologic patterns may cause difficulty in distinguishing this tumor from other primary or metastatic neoplasms.
  • CASE: A 32-year-old man presented with a mass in the distal side of the left leg that was diagnosed as classic adamantinoma by open biopsy.
  • CONCLUSION: The diagnosis of adamantinoma requires knowledge of compatible clinical and radiologic studies as well as understanding of the variable histologic patterns that one may encounter.
  • Fine needle aspiration biopsy is particularly useful in the diagnosis of recurrent and metastatic adamantinoma.
  • This case report describes a distinctive cytomorphologic feature of nuclear grooves that may be a useful aid in distinguishing the tumor cells of adamantinoma from other cell types.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Neoplasms / diagnosis. Lung / pathology. Lung Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Tibia / pathology
  • [MeSH-minor] Adult. Amputation. Biomarkers, Tumor / analysis. Biomarkers, Tumor / biosynthesis. Biopsy, Fine-Needle. Cell Shape. Diagnosis, Differential. Disease Progression. Epithelial Cells / pathology. Humans. Magnetic Resonance Imaging. Male. Nuclear Envelope / pathology. Prognosis

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  • (PMID = 17017449.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Al-Daraji WI, Al-Daraji UW, Al-Mahmoud RM: Adamantinoma associated with botryomycosis: the first report of this rare association after trauma. Clin Exp Dermatol; 2008 Jul;33(4):433-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma associated with botryomycosis: the first report of this rare association after trauma.
  • We report for the first time to our knowledge a unique case of both botryomycosis and adamantinoma in the right tibia of the same patient at an area of previous trauma.
  • Although both botryomycosis and adamantinoma usually have a history of trauma, as in our patient, a causal relationship will need more cases to establish a possible link.
  • [MeSH-major] Adamantinoma / complications. Granulomatous Disease, Chronic / complications. Staphylococcal Skin Infections / complications. Tibia. Wounds, Nonpenetrating / complications

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  • (PMID = 18312455.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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25. Desai SS, Jambhekar N, Agarwal M, Puri A, Merchant N: Adamantinoma of tibia: a study of 12 cases. J Surg Oncol; 2006 Apr 1;93(5):429-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of tibia: a study of 12 cases.
  • BACKGROUND: Adamantinoma is a rare tumor of long bones that can be mistaken for a carcinoma, and numerous other lesions such as myoepithelial tumor, malignant mixed tumor of bone, fibrous dysplasia/osteofibrous dysplasia, and vascular tumors.
  • Radiologically the tumor presented as a lytic, eccentric, intracortical lesion in the tibia.
  • DISCUSSION: In this article, an attempt is made to study the morphology, biology, and the differential diagnoses of adamantinoma of long bones.
  • [MeSH-major] Adamantinoma. Bone Neoplasms. Tibia

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16550582.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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26. Izquierdo FM, Ramos LR, Sánchez-Herráez S, Hernández T, de Alava E, Hazelbag HM: Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype. Am J Surg Pathol; 2010 Sep;34(9):1388-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dedifferentiated classic adamantinoma of the tibia: a report of a case with eventual complete revertant mesenchymal phenotype.
  • We report a case of an adamantinoma with a revertant sarcomatoid transformation that showed a complete loss of epithelial differentiation.
  • On the en bloc resection specimen, areas of classic adamantinoma were found but most of the tumor corresponded to a high-grade neoplasm with 2 histologic patterns: one made up by epithelial nests with a basaloid arrangement and positive for pankeratins and so-called glandular keratins, and a second sarcomatoid component, negative for these epithelial markers.
  • However, our case represents the extreme end of the sarcomatoid dedifferentiation of a classic adamantinoma with complete sarcomatoid transformation and total loss of epithelial markers.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Sarcoma / pathology. Tibia / pathology
  • [MeSH-minor] Adult. Biomarkers / metabolism. Biomarkers, Tumor / metabolism. Cell Transformation, Neoplastic. Humans. Keratins / metabolism. Male. Mesoderm / pathology. Neoplasms, Second Primary. Phenotype. Treatment Outcome

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  • (PMID = 20717000.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / CAM 5.2 antigen; 68238-35-7 / Keratins
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27. Frey SP, Hardes J, Ahrens H, Winkelmann W, Gosheger G: Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature. J Cancer Res Clin Oncol; 2008 Apr;134(4):427-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Total tibia replacement using an allograft (in a patient with adamantinoma). Case report and review of literature.
  • INTRODUCTION: Adamantinoma is a very rare, low-grade, malignant bone tumour that accounts for approximately 0.4% of all primary bone tumours.
  • CASE PRESENTATION: We present a case of adamantinoma of the tibia, in which a resection of the whole tibia and reconstruction with a total tibia allograft was necessary.
  • It is often difficult to distinguish an adamantinoma from other tumours.
  • The most frequent described method to treat adamantinoma is wide resection and the use of an allograft.
  • [MeSH-major] Adamantinoma / surgery. Tibia / surgery

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  • [Language] eng
  • [Publication-type] Journal Article; Review
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28. Szendroi M, Antal I, Arató G: Adamantinoma of long bones: a long-term follow-up study of 11 cases. Pathol Oncol Res; 2009 Jun;15(2):209-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of long bones: a long-term follow-up study of 11 cases.
  • The aim of this study was to evaluate the clinicopathological features and prognostic significances of 11 histologically proven adamantinoma cases based on an average 12,7 year long follow-up.
  • The initial diagnosis at referral was other than adamantinoma in six patients (fibrous dysplasia, carcinoma metastasis, osteofibrous dysplasia, bone cyst, non-ossifying fibroma), referring to the differential diagnostic problems.
  • All adamantinoma were positive for cytokeratins often in coexpression with vimentin.
  • Intralesional curettage (2 pts) was followed by recurrence of the tumor.
  • One patient died 9 years after recognition of the tumor of pulmonary metastases.
  • Adamantinoma of the long bones is a low grade malignant tumor, which clinical outcome is difficult to predict based on histology or surgical stage of the tumor.
  • Wide surgical margin, e.g. resection the tumor reduces the rate of recurrence.
  • This study underlines that recurrences do occur even decades after recognition the tumor, therefore a life-long follow-up of the patient is necessary.
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Tibia

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  • (PMID = 19048403.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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29. Khanna M, Delaney D, Tirabosco R, Saifuddin A: Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis. Skeletal Radiol; 2008 Dec;37(12):1077-84

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma and adamantinoma: correlation of radiological imaging features with surgical histology and assessment of the use of radiology in contributing to needle biopsy diagnosis.
  • OBJECTIVES: The aim of this study was to correlate the imaging features with surgical histology for tibial osteofibrous dysplasia (OFD), osteofibrous dysplasia-like adamantinoma (OFD/LA) and classical adamantinoma and to determine the additional role of imaging in suggesting a correct diagnosis in cases of needle biopsy misdiagnosis.
  • RESULTS: The 24 cases comprised five OFD, 11 OFD/LA and eight adamantinoma based on surgical resection histology.
  • The mean length of OFD was 6.1 cm (range 2-8.5 cm), for OFD/LA was 6.5 cm (range 2-13 cm) and for adamantinoma was 13.2 cm (range 6.5-26 cm).
  • Four of 19 cases had a different needle biopsy result compared to the final histology, three cases being upgraded from an OFD/LA or OFD to classical adamantinoma.
  • The radiological features of these three cases were more in keeping with a diagnosis of adamantinoma.
  • CONCLUSIONS: A diagnosis of classical adamantinoma is suggested by an extensive lesion with moth-eaten margins and complete involvement of the medullary cavity on axial MR imaging.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / surgery. Fibrous Dysplasia of Bone / diagnosis. Fibrous Dysplasia of Bone / surgery

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  • (PMID = 18690429.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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30. Fujii H, Honoki K, Enomoto Y, Kasai T, Kido A, Amano I, Kumamoto M, Morishita T, Mii Y, Nonomura A, Takakura Y: Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report. Virchows Arch; 2006 Nov;449(5):579-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma-like Ewing's sarcoma with EWS-FLI1 fusion gene: a case report.
  • Recent studies have advocated the genotypic and phenotypic delineation of a novel Ewing's sarcoma histologic variant showing epithelial features defined as "adamantinoma-like Ewing's sarcoma".
  • The diagnosis of the lesion was confirmed as Ewing's sarcoma by the presence of the EWS-FLI1 fusion transcript, and could be defined as the so-called "adamantinoma-like Ewing's sarcoma".
  • [MeSH-major] Adamantinoma / pathology. Bone Neoplasms / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. Sarcoma, Ewing / pathology

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  • (PMID = 17016721.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / EWS-FLI fusion protein; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS
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31. Piña-Oviedo S, Del Valle L, Padilla-Longoria R, Mendoza-Ramón H, Ortiz-Hidalgo C: Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin. Pathol Oncol Res; 2008 Dec;14(4):497-502
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin.
  • Although cases of adamantinoma located to the axial skeleton have been reported either as recurrent or metastatic disease, only two cases of primary adamantinoma located to the thoracic wall have been previously described.
  • In this study we present the clinical, radiological and histopathological features of a 24-year-old male with a slow growing, solid-cystic, painful mass, located to the right 11th rib, which was morphological and immunohistochemically diagnosed as a primary classic adamantinoma.
  • [MeSH-major] Adamantinoma / pathology. Ribs / pathology

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  • (PMID = 18409022.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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32. Mavrogenis AF, Sakellariou VI, Tsibidakis H, Papagelopoulos PJ: Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant. J Int Med Res; 2009 Jul-Aug;37(4):1238-45

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adamantinoma of the tibia treated with a new intramedullary diaphyseal segmental defect implant.
  • Histological diagnosis was consistent with adamantinoma, a rare primary bone tumour.
  • [MeSH-major] Adamantinoma / pathology. Adamantinoma / surgery. Limb Salvage / methods. Tibia / pathology. Tibia / surgery

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  • (PMID = 19761710.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Makhson AN, Bulycheva IV, Kuz'min IV, Pavlenko TV: [Adamantinoma of long tubal bones]. Arkh Patol; 2006 Jan-Feb;68(1):14-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adamantinoma of long tubal bones].
  • Immunohistochemistry helps in differential diagnosis of this tumor.
  • The surgeons should be warned against enucleation of the tumor.
  • [MeSH-major] Adamantinoma / ultrastructure. Femoral Neoplasms / ultrastructure. Tibia / ultrastructure

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  • (PMID = 16544529.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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34. Łapienis M, Kaczmarczyk D, Zimmer-Nowicka J, Niedźwiecka I, Jesionek-Kupnicka D, Morawiec-Bajda A: [Ameloblastoma of the maxillary sinus--a case report]. Otolaryngol Pol; 2008;62(6):784-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ameloblastoma of the maxillary sinus--a case report].
  • [Transliterated title] Szkliwiak zatoki szczekowej--opis przypadku.
  • Ameloblastoma (adamantinoma) is a benign neoplasm deriving from the enamel organ.
  • About 20% of described cases of ameloblastoma relate to the jaw, its very rare location is gingiva or cheak tunica mucosa.
  • The essay presents a case of ameloblastoma of a maxillary sinus in a 65-year-old man.
  • The diagnostic and treatment algorithm in ameloblastoma is discussed.
  • [MeSH-major] Ameloblastoma / pathology. Ameloblastoma / surgery. Maxillary Sinus Neoplasms / pathology. Maxillary Sinus Neoplasms / surgery

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  • (PMID = 19205533.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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35. Farah-Klibi F, Ferchichi L, Beyâa Rassou H, Zairi I, Rameh S, Adouani A, Ben Jilani SB, Zermani R: [Adenomatoid odontogenic tumor: two cases]. Rev Stomatol Chir Maxillofac; 2007 Feb;108(1):61-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Adenomatoid odontogenic tumor: two cases].
  • INTRODUCTION: Adenomatoid odontogenic tumor, initially referred to as adenoameloblastoma, is a rare and benign odontogenic tumor.
  • CASE REPORTS: We report two cases of adenomatoid odontogenic tumor, which illustrate the radiological and anatomic features of this tumor.
  • DISCUSSION: The clinical, radiological and histological features of adenomatoid odontogenic tumor are distinct from those of ameloblastoma.
  • This tumor is frequently misdiagnosed as other odontogenic cysts or tumors.
  • We discuss the anatomoclinical features and the histogenesis of this rare tumor.

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  • (PMID = 17275864.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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36. Park YK, Ryu KN, Han CS: Synchronous intracortical adamantinomas with keratin cyst formation. Skeletal Radiol; 2006 Mar;35(3):185-9
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  • Adamantinoma of the long bones is a rare primary bone tumor of uncertain embryogenesis.
  • This keratin cyst formation is quite an unusual finding in classic adamantinoma.
  • [MeSH-major] Adamantinoma / diagnosis. Bone Cysts / diagnosis. Bone Neoplasms / diagnosis. Fibula / pathology. Keratins / analysis. Magnetic Resonance Imaging. Tibia / pathology

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  • (PMID = 16217667.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 68238-35-7 / Keratins
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37. Motamedi MH, Shafeie HA, Azizi T: Salvage of an impacted canine associated with an adenomatoid odontogenic tumour: a case report. Br Dent J; 2005 Jul 23;199(2):89-90

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The adenomatoid odontogenic tumour (AOT) has been known by a number of descriptive names (adenoameloblastoma, ameloblastic adenomatoid tumour, glandular ameloblastoma, and adenomatoid ameloblastoma) since it was first reported and later recognised as a distinct odontogenic lesion unrelated to ameloblastoma.
  • Although it was considered to be a variant of ameloblastoma at one time leading surgeons to perform unduly aggressive surgery, the treatment outcome experience has borne out the benign, nonaggressive nature of this lesion.

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  • (PMID = 16041334.001).
  • [ISSN] 0007-0610
  • [Journal-full-title] British dental journal
  • [ISO-abbreviation] Br Dent J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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38. Spiegelberg BG, Sewell MD, Coltman T, Blunn GW, Flanagan AM, Cannon SR, Briggs TW: Below-knee amputation through a joint-sparing proximal tibial replacement for recurrent tumour. J Bone Joint Surg Br; 2009 Jun;91(6):815-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report a case which highlights the progression of osteofibrous dysplasia to adamantinoma and questions whether intralesional curettage is the appropriate treatment.
  • [MeSH-major] Adamantinoma / surgery. Amputation / methods. Bone Diseases, Developmental / surgery. Bone Neoplasms / surgery. Neoplasm Recurrence, Local / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Humans. Pain / surgery. Skiing / injuries. Tibial Fractures / complications

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  • [ErratumIn] J Bone Joint Surg Br. 2009 Aug;91(8):1120. Speigelberg, B G I [corrected to Spiegelberg B G I]
  • (PMID = 19483239.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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39. Napp M, Stengel BA, Buschmann J, Döhler JR: [Osteofibrous dysplasia campanacci of the tibia. A 12-year follow-up]. Chirurg; 2009 Mar;80(3):241-4
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  • This article concerns a rare tumor-like lesion primarily in the tibial diaphysis in young patients.
  • Despite the controversial indication, we recommend this method due to the disorder's putative relationship with malignant adamantinoma.

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  • (PMID = 18690418.001).
  • [ISSN] 1433-0385
  • [Journal-full-title] Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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40. Deyrup AT, Montag AG: Epithelioid and epithelial neoplasms of bone. Arch Pathol Lab Med; 2007 Feb;131(2):205-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Metastasis / pathology

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  • (PMID = 17284104.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 86
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41. Folpe AL, Goldblum JR, Rubin BP, Shehata BM, Liu W, Dei Tos AP, Weiss SW: Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases. Am J Surg Pathol; 2005 Aug;29(8):1025-33
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  • [Title] Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases.
  • More than 85% of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), or "Ewing family of tumors" (EFTs), have the translocation, t (11;22) (q24;q12), with others having variant translocations.
  • We therefore studied a large group of genetically confirmed EFTs to more completely understand the morphologic and immunophenotypic spectrum of this rare sarcoma.
  • Histologically, 46 cases (73%) showed only typical features of ES, 9 cases (16%) showed features of PNET, 3 cases (5%) showed "adamantinoma-like" features, 3 cases (5%) corresponded to "atypical Ewing sarcoma," 3 cases (5%) showed principally intersecting fascicles of spindled cells, and 2 cases had abundant hyalinized matrix.
  • HMWCK was expressed only in "adamantinoma-like" EFTs, none of which expressed DES.
  • In conclusion, most, but not all, EFTs can be accurately diagnosed using time-honored morphologic criteria and ancillary immunohistochemistry.
  • However, genetic confirmation remains essential for the diagnosis of unusual morphologic variants of EFT, including "adamantinoma-like," spindled, sclerosing, and clear cell/anaplastic variants.
  • Therefore, to exclude or confirm the diagnosis of Ewing's sarcoma in round cell sarcomas having a variety of patterns but not specifically conforming to a tumor of known lineage (eg, rhabdomyosarcoma), cytogenetics, and/or molecular analysis is required.

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  • (PMID = 16006796.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Desmin; 0 / FLII protein, human; 0 / Gelsolin; 0 / Microfilament Proteins; 0 / Receptors, Cytoplasmic and Nuclear; 68238-35-7 / Keratins; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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42. Weber K, Damron TA, Frassica FJ, Sim FH: Malignant bone tumors. Instr Course Lect; 2008;57:673-88
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  • Rare tumors such as chordoma and adamantinoma have anatomic predilections for the sacrum and tibia, respectively.
  • The primary symptom of a patient with a malignant bone tumor is pain, which often occurs at rest or at night.
  • Patients with a likely malignancy require thorough staging to determine the extent of disease and a well-planned biopsy for accurate diagnosis.
  • Knowledge of specific tumor characteristics and treatment options for osteosarcoma, Ewing's sarcoma, chondrosarcoma, malignant fibrous histiocytoma, chordoma, and adamantinoma is important.

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  • (PMID = 18399615.001).
  • [ISSN] 0065-6895
  • [Journal-full-title] Instructional course lectures
  • [ISO-abbreviation] Instr Course Lect
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 42
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43. Requena L, Kutzner H: Seborrheic keratosis with pseudorosettes and adamantinoid seborrheic keratosis: two new histopathologic variants. J Cutan Pathol; 2006 Sep;33 Suppl 2:42-5
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  • RESULTS: One lesion showed abundant intercellular mucin, closely resembling to adamantinoma, and therefore was named adamantinoid seborrheic keratosis.
  • [MeSH-major] Adamantinoma / pathology. Keratinocytes / pathology. Keratosis, Seborrheic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16972954.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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44. Almeida Herrero F, Silvestre Muñoz A, Martinez Rodriguez M, Gomar Sancho F: Ossifying fibroma of long bones in adults: a case report. Acta Orthop Belg; 2006 Dec;72(6):786-9
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  • No epitheloid cells are found as in adamantinoma.

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  • (PMID = 17260623.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Bone Substitutes
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45. Ieni A, Barresi V, Grosso M, Rosa MA, Tuccari G: Lactoferrin immuno-expression in human normal and neoplastic bone tissue. J Bone Miner Metab; 2009;27(3):364-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lactoferrin (Lf) expression was investigated by using a Lf monoclonal antibody in 50 formalin-fixed and paraffin-embedded human bone tumours [10 giant cell tumours (GCTs), 7 osteoid osteomas, 6 ossifying fibromas, 19 enchondromas, 2 chondroblastomas, 2 chondrosarcomas, 2 chondroblastic osteosarcomas, 1 myeloma and 1 adamantinoma] as well as in 8 samples of adult and foetal human normal bone specimens.
  • Lf immuno-expression with a variable ID score was encountered in 19/50 tumours and specifically in 10/10 GCTs, in 5/7 osteoid osteomas, in 2/2 chondroblastomas as well as in the adamantinoma and in the myeloma.

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  • (PMID = 19240970.001).
  • [ISSN] 0914-8779
  • [Journal-full-title] Journal of bone and mineral metabolism
  • [ISO-abbreviation] J. Bone Miner. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] EC 3.4.21.- / Lactoferrin
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46. Sakellariou VI, Mavrogenis AF, Papagelopoulos PJ: Limb salvage surgery using the intramedullary diaphyseal segmental defect fixation system. J Long Term Eff Med Implants; 2008;18(1):59-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histological diagnosis included adamantinoma, synovial sarcoma, multiple myeloma, metastatic renal cell carcinoma, myeloid carcinoma of the thyroid gland, and adenocarcinoma of the stomach.
  • At the latest examination, five patients were free of local or distant disease and one patient had deceased with distant disease, without evidence of local recurrence.

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  • (PMID = 19348612.001).
  • [ISSN] 1050-6934
  • [Journal-full-title] Journal of long-term effects of medical implants
  • [ISO-abbreviation] J Long Term Eff Med Implants
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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47. Vera Sempere FJ, Artes Martínez MJ, Vera Sirera B, Bonet Marco J: Follicular adenomatoid odontogenic tumor: immunohistochemical study. Med Oral Patol Oral Cir Bucal; 2006 Jul;11(4):E305-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Follicular adenomatoid odontogenic tumor: immunohistochemical study.
  • Adenomatoid odontogenic tumor (AOT) is an uncommon benign odontogenic lesion that affects young patients, with female predominance, mainly in second decade, showing a radiolucent unilocular image associated with an unerupted tooth, usually a canine.
  • In spite of previous and confusing denominations, such as adenoameloblastoma or adenomatoid ameloblastic tumor, AOT is a benign tumor with a very low rate of recurrence, that show a peculiar morphological picture (basaloid appearance with glandular-like structures, calcifying areas, and amiloid-like material) that allow its histopathological recognition.

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  • (PMID = 16816813.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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48. Ulmar B, Delling G, Werner M, Huch K, Reichel H: Classical and atypical location of adamantinomas--presentation of two cases. Onkologie; 2006 Jun;29(6):276-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The diagnostic work-up including biopsy verified an adamantinoma in both cases.
  • In the younger patient, the tumor was located in the metatarsals 4 and 5, in the older patient in the left tibial diaphyses.
  • In both patients, an en-bloc resection of the tumor with wide surgical margins was performed.
  • [MeSH-major] Adamantinoma / diagnosis. Adamantinoma / surgery. Bone Neoplasms / diagnosis. Bone Neoplasms / surgery. Metatarsal Bones / surgery. Tibia / surgery

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  • (PMID = 16783903.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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49. Choi E, Wert M, Guerrieri C, Tucci J: A pathologic fracture of an intracortical chondroma masking as an osteoid osteoma. Orthopedics; 2010 Nov;33(11):845
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The differential diagnosis of a tibial intracortical diaphyseal lesion includes osteoid osteoma, periosteal chondroma, nonossifying fibroma, osteofibrous dysplasia, and adamantinoma.

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 21053879.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Papagelopoulos PJ, Savvidou OD, Mavrogenis AF, Galanis EC, Shaughnessy WJ, Unni KK, Sim FH: Lateral malleolus en bloc resection and ankle reconstruction for malignant tumors. Clin Orthop Relat Res; 2005 Aug;(437):209-18
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  • There were four osteosarcomas, three chondrosarcomas, two Ewing's sarcomas, and one adamantinoma.
  • At the latest followup, all 10 patients showed no evidence of disease.
  • Five patients who had primary or late ankle arthrodesis had a Musculoskeletal Tumor Society and International Society of Limb Salvage functional score of 28 points (92%), and two adolescents who had postoperative bracing alone had a functional score of 24 points (80%).

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  • (PMID = 16056051.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Llombart-Bosch A, Machado I, Navarro S, Bertoni F, Bacchini P, Alberghini M, Karzeladze A, Savelov N, Petrov S, Alvarado-Cabrero I, Mihaila D, Terrier P, Lopez-Guerrero JA, Picci P: Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch; 2009 Nov;455(5):397-411
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ewing's sarcoma (ES)/peripheral neuroectodermal tumor (PNET) are malignant neoplasms affecting children and young adults.
  • This study confirms the structural heterogeneity of ES/PNET, distinguishing three major subtypes: conventional ES (280 cases); PNET (53 cases); and atypical ES/PNET (80), including large cells, vascular-like patterns, spindle pattern, and adamantinoma-like configuration.
  • [MeSH-major] Antibodies. Biomarkers, Tumor / analysis. Bone Neoplasms / pathology. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Sarcoma, Ewing / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD / biosynthesis. Antigens, CD57 / biosynthesis. Antigens, CD99. Caveolin 1 / biosynthesis. Cell Adhesion Molecules / biosynthesis. Child. Child, Preschool. Disease Progression. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Infant. Kaplan-Meier Estimate. Male. Middle Aged. Prognosis. Proto-Oncogene Protein c-fli-1 / biosynthesis. Young Adult

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  • (PMID = 19841938.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, CD; 0 / Antigens, CD57; 0 / Antigens, CD99; 0 / Biomarkers, Tumor; 0 / CAV1 protein, human; 0 / CD99 protein, human; 0 / Caveolin 1; 0 / Cell Adhesion Molecules; 0 / FLI1 protein, human; 0 / Proto-Oncogene Protein c-fli-1
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52. Weinreb I, Goldstein D, Perez-Ordoñez B: Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. Am J Surg Pathol; 2008 Nov;32(11):1742-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome.
  • Focally, the tumor abruptly produced keratinizing cells and frank squamous pearls.
  • The tumor showed diffuse expression of CD99, high molecular weight keratin, p63, cytokeratin (CK) 5/6, AE1/AE3, CAM5.2, CK19, and focal CK14.
  • Subsequently, the tumor was shown to harbor the t(11;22) involving EWSR1 and FLI-1 by reverse transcription-polymerase chain reaction, characteristic of EFT's, which was confirmed by dual color break apart fluorescence in-situ hybridization analysis.
  • This tumor is related to, if not an example of the recently described "adamantinoma-like" EFT and demonstrates a potential diagnostic pitfall.
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Keratins / biosynthesis. Male. Membrane Proteins / biosynthesis. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Protein c-fli-1 / genetics. RNA-Binding Protein EWS. Reverse Transcriptase Polymerase Chain Reaction. Translocation, Genetic. Vagus Nerve / pathology

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  • (PMID = 18769338.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / EWS-FLI fusion protein; 0 / Membrane Proteins; 0 / Oncogene Proteins, Fusion; 0 / Proto-Oncogene Protein c-fli-1; 0 / RNA-Binding Protein EWS; 68238-35-7 / Keratins
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53. Ramseier LE, Malinin TI, Temple HT, Mnaymneh WA, Exner GU: Allograft reconstruction for bone sarcoma of the tibia in the growing child. J Bone Joint Surg Br; 2006 Jan;88(1):95-9
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  • Two had Ewing's sarcoma, one an adamantinoma and 16 osteosarcoma, one with multifocal disease.
  • Five patients have died; the other 14 were free from disease at the time of follow-up.
  • [MeSH-minor] Adamantinoma / surgery. Adolescent. Child. Female. Follow-Up Studies. Humans. Leg Length Inequality / etiology. Male. Reoperation / methods. Sarcoma, Ewing / surgery. Treatment Outcome. Wound Healing

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  • (PMID = 16365128.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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54. Jeon DG, Lee SY, Kim JW: Bone primary sarcomas undergone unplanned intralesional procedures - the possibility of limb salvage and their oncologic results. J Surg Oncol; 2006 Dec 1;94(7):592-8
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  • An unplanned surgical excision occurs when tumors are removed without the appropriate preoperative evaluation and consideration for the need to obtain tumor-free margins.
  • Residual tumor tissue as a result of unplanned excision of soft tissue sarcoma is a risk factor for local recurrence.
  • There were 22 (88%) cases of osteosarcomas, 2 (8%) MFH of bone and 1 (4%) adamantinoma.

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17066433.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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55. Wysluch A, Hölzle F, Maurer P: [Giant ameloblastoma of the jaw]. HNO; 2009 Nov;57(11):1193-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant ameloblastoma of the jaw].
  • [Transliterated title] Monströses Ameloblastom des Unterkiefers.
  • Ameloblastomas represent benign, epithelial alveolar tumors, which originate from epithelial enamel cells (ameloblasts).
  • As demonstrated by the case of a 71-year-old patient with giant ameloblastoma of the upper jaw, early resection is recommended.
  • [MeSH-major] Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis

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  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Dec;104(6):e17-24 [17942338.001]
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  • (PMID = 19727626.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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56. Wang J, Zhang RY: [Ectopic hamartomatous thymoma: a clinicopathological and immunohistochemical study of two cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Jul;34(7):397-401
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  • They formed small solid islands and adamantinoma-like "nastomosing cords", or appeared as lining cells in large cystic spaces.
  • CONCLUSIONS: EHT is a benign tumor that occurs predominantly in the lower neck region of young to middle-aged males.
  • Immunohistochemical study revealed myoepithelial differentiation of the spindle cells, suggesting EHT is a mixed tumor composed of epithelial and myoepithelial cells.
  • EHT possibly originates from the remnants of cervical sinus of His, and therefore, may be renamed as branchial anlage mixed tumor.

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  • (PMID = 16251042.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anion Exchange Protein 1, Erythrocyte; 0 / Keratins, Type II; 0 / Mucin-1; 0 / Vimentin
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57. Abada RL, Kadiri F, Tawfik N, Benchakroun N, Bouchbika Z, Chekkoury AI, Benchakroun Y, Benider A: [Multiple metastases of a mandibular ameloblastoma]. Rev Stomatol Chir Maxillofac; 2005 Jun;106(3):177-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Multiple metastases of a mandibular ameloblastoma].
  • INTRODUCTION: Ameloblastoma is a benign odontogenic tumor which can be locally aggressive and invasive.
  • Metastases are rare but possible and must be considered as a malignant form of the tumor.
  • OBSERVATION: A 50-year-old woman presented a jugal metastasis of a mandibular ameloblastom which had been treated several times 28 years earlier.
  • DISCUSSION: The absence of any histological sign of malignity in the primary tumor and in the metastases, as observed in our patient, is remarkable.
  • Progression is very slow, like for the primary tumor.
  • Several factors predictive of metastasis have been described: female gender, age at onset of primary tumor (2nd to 3rd decade) and multiple local recurrences.
  • [MeSH-major] Ameloblastoma / secondary. Mandibular Neoplasms / pathology

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  • (PMID = 15976707.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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58. Black CC, Addante RR, Mohila CA: Intraosseous ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Nov;110(5):585-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraosseous ameloblastoma.
  • Ameloblastomas are benign slow-growing aggressive neoplasms with a poorly understood potential for rare metastasis.
  • Microscopically, ameloblastomas are recognizable from their recapitulation of embryologic ameloblasts and stellate reticulum.
  • Treatment planning for a given tumor includes consideration of location, primary versus recurrent, size, presence of cortical perforation, and age and health of the patient.
  • [MeSH-major] Ameloblastoma / diagnosis. Jaw Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 May;111(5):536; author reply 536-8 [21306924.001]
  • (PMID = 20580278.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Vallicioni J, Loum B, Dassonville O, Poissonnet G, Ettore F, Demard F: [Ameloblastomas]. Ann Otolaryngol Chir Cervicofac; 2007 Sep;124(4):166-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ameloblastomas].
  • OBJECTIVES: The aim of this work was to report on the clinical, radiological and histological characteristics of ameloblastomas concerning bone structures of the face, rare but not exceptional tumours, and to communicate our experience of their treatment.
  • MATERIAL AND METHODS: The authors reexamined six recent cases of patients presenting with ameloblastoma at the centre Antoine Lacassagne in Nice.
  • The diagnostic context, the treatment and the development of the disease are given in detail, emphasizing the frequency of local relapse of this histologically benign condition.
  • RESULTS: The study of these cases confirmed the benefit of surgical treatment of ameloblastoma.
  • [MeSH-major] Ameloblastoma / epidemiology. Ameloblastoma / pathology. Mandibular Neoplasms / epidemiology. Mandibular Neoplasms / pathology

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  • (PMID = 17673157.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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60. Mendenhall WM, Werning JW, Fernandes R, Malyapa RS, Mendenhall NP: Ameloblastoma. Am J Clin Oncol; 2007 Dec;30(6):645-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma.
  • The purpose of this article is to review the pertinent literature and discuss the optimal treatment and outcomes for patients with ameloblastoma.
  • Ameloblastoma is an uncommon benign, locally aggressive odontogenic neoplasm that usually occurs in the vicinity of the mandibular molars or ramus.
  • Uncontrolled, ameloblastoma may cause significant morbidity and occasionally death.
  • The majority of ameloblastomas are multicystic, which are more difficult to eradicate than the unicystic and peripheral varieties.
  • In contrast, conservative procedures such as enucleation and/or curettage result in local control rates of approximately 80% and 50% for unicystic and multicystic ameloblastomas, respectively.
  • Limited experience with radiotherapy indicates that it may reduce the risk of progression and result in long-term local control in the occasional patient with incompletely resectable disease.
  • The optimal treatment for ameloblastoma is wide en bloc resection.
  • Radiotherapy may improve the likelihood of local control in the occasional patient with incompletely resectable tumor.
  • [MeSH-major] Ameloblastoma / radiotherapy. Ameloblastoma / surgery. Jaw Neoplasms / radiotherapy. Jaw Neoplasms / surgery

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  • (PMID = 18091060.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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61. Gilijamse M, Leemans CR, Winters HA, Schulten EA, van der Waal I: Metastasizing ameloblastoma. Int J Oral Maxillofac Surg; 2007 May;36(5):462-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasizing ameloblastoma.
  • Ameloblastomas are locally invasive tumours of odontogenic origin with a high propensity for local recurrence.
  • Here is presented a case of a 26-year-old woman with a recurrent ameloblastoma of the mandible and a metastatic lymph node in the homolateral neck.
  • [MeSH-major] Ameloblastoma / secondary. Lymphatic Metastasis / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 17275258.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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62. Atalay B, Soluk M, Brkić A, Emes Y, Cetin O, Olgac V: Desmoplastic ameloblastoma. J Craniofac Surg; 2009 Nov;20(6):2256-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic ameloblastoma.
  • Ameloblastoma is a rare benign odontogenic epithelial tumor characterized by abnormal cell growth, which easily infiltrates and destroys surrounding bony tissues.
  • One of the 3 clinical variants of ameloblastoma is desmoplastic type, with involvement of the maxillary arch more often than the mandible.
  • Its histopathologic variant characterized by extensive squamous metaplasia, islands of tumor cells, and sometimes keratin formation is known as desmoplastic acanthomatous ameloblastoma.The aim of this report was to present an unusual case of symphysis located desmoplastic acanthomatous ameloblastoma in a 56-year-old female patient, who was experiencing laryngeal carcinoma 2 years ago.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Neoplasms, Second Primary / pathology

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  • (PMID = 19934686.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Essaadi M, Sif A, Benzaouia A, Rouadi S, Abada RL, Mahtar M, Roubal M, Janah A, Kadiri F, Rifki A: [Recurrent ameloblastoma on a rib graft after 33 years (a case report and review of the literature)]. Rev Laryngol Otol Rhinol (Bord); 2010;131(4-5):303-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Recurrent ameloblastoma on a rib graft after 33 years (a case report and review of the literature)].
  • INTRODUCTION: The recurrence of an ameloblastoma is generally due to insufficient margins of resection or to the aggressiveness of the tumour which is regarded as locally malignant.
  • We report the case of a recurrent ameloblastoma on autologus rib graft which occurred 33 years after the surgery.
  • The histopathologic diagnosis was an ameloblastoma with healthy limits and without invasion of the soft tissues.
  • CONCLUSION: The pathogenesis of the recurrence of an ameloblastoma on autologus osseous graft is still not well understood.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Ribs / transplantation

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  • (PMID = 21866745.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] France
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64. Zhang J, Gu Z, Jiang L, Zhao J, Tian M, Zhou J, Duan Y: Ameloblastoma in children and adolescents. Br J Oral Maxillofac Surg; 2010 Oct;48(7):549-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma in children and adolescents.
  • This study first reviewed the data of 37 patients aged 18 years and younger with ameloblastoma over a 16-year period and then reviewed the literature on this subject from 1970 to 2009.
  • Of 37 patients with ameloblastoma, 23 were male and 14 were female, a ratio of 1.6:1.
  • A series of literature review disclosed 233 well-documented cases of ameloblastoma in children and adolescents.
  • Owing to a high recurrent rate of ameloblastoma, solid type of tumors should be approached with radical surgical treatment, while conservative measure can be applied selectively to unicystic type.
  • Long-term follow-up is important because recurrence may appear years after tumor removal.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • [Copyright] Copyright © 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19783332.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Scotland
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65. Bozza F, Marcelli VA, Pistilli R, Govoni FA, Marsico C: Maxillary ameloblastoma. Minerva Stomatol; 2006 Apr;55(4):215-22

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Maxillary ameloblastoma.
  • Maxillary ameloblastoma is a rare odontogenic neoplasm that is histologically benign and originates from epithelial cells present in bone tissue.
  • The risk, in particularly extensive forms, that the ameloblastoma will invade extra-maxillary structures such as the orbit, the pterygomaxillary fossa, the infratemporal fossa and the base of the skull, means that surgical treatment is difficult if it is to be oncologically radical while respecting function and aesthetics.
  • Our experience in treating 2 cases of maxillary ameloblastoma is reported.
  • [MeSH-major] Ameloblastoma / surgery. Maxillary Neoplasms / surgery

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  • (PMID = 16618996.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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66. Bansal M, Chaturvedi TP, Bansal R, Kumar M: Acanthomatous ameloblastoma of anterior maxilla. J Indian Soc Pedod Prev Dent; 2010 Jul-Sep;28(3):209-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acanthomatous ameloblastoma of anterior maxilla.
  • The unusual case of acanthomatous ameloblastoma occurring in maxillary left anterior region in a 13-year-old female child is presented with chief complaint of swelling in the upper left anterior region since one year and spacing between maxillary left central incisor and canine.
  • Microscopic examination of surgically excised specimen revealed solid epithelial cell nests with peripheral palisading ameloblastic cells and the central squamous cell assemblage that was consistent with the findings of acanthomatous ameloblastoma type.
  • Acanthomatous ameloblastoma is the extremely rare variant.
  • [MeSH-major] Ameloblastoma / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 21157056.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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67. Odukoya O, Effiom OA: Clinicopathological study of 100 Nigerian cases of ameloblastoma. Niger Postgrad Med J; 2008 Mar;15(1):1-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological study of 100 Nigerian cases of ameloblastoma.
  • SUMMARY: Clinicopathological analysis and growth rate study of 100 cases of ameloblastoma was undertaken.
  • The estimated monthly growth rate (EMGR) of ameloblastoma was observed to be slower in males although the mean tumour volume recorded in females was lower than males in the series.
  • The biologic aggression of 4 various types of ameloblastoma was predicted using EMGR and average volume of tumour at hospital presentation as predictive markers.
  • Solid multicystic ameloblastoma was observed with the fastest EMGR of 0.81 cm(3)/month.
  • Peripheral ameloblastoma was observed with the slowest EMGR of 0.17 cm(3)/ month.
  • It was concluded that all the 4 types of ameloblastoma observed were clinically distinct and showed varying biologic aggression.
  • It is therefore necessary to distinguish between the various clinical types of ameloblastoma before a clinician proceeds with definitive treatment.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology

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  • (PMID = 18408774.001).
  • [ISSN] 1117-1936
  • [Journal-full-title] The Nigerian postgraduate medical journal
  • [ISO-abbreviation] Niger Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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68. Brooks JK, Al-Mubarak H, Ribera MJ, Cohen PD, Ross DS, Scheper MA: Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma. Quintessence Int; 2010 Mar;41(3):209-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma.
  • Ameloblastomas are benign aggressive odontogentic tumors that exhibit insidious growth rates with attainment of extensive dimesions.
  • Because ameloblastomas are not usually symptomatic until late in their clinical course, few are detected early.
  • This article reports an atypical case of a small, painful ameloblastoma arising between the roots of the mandibular left canine and lateral incisor in a 66-year-old female.
  • Histopathology revealed a "hybrid" ameloblastoma with a pronounced desmoplastic pattern and acanthomatous changes.
  • Timely recognition and intervention of ameloblastomas may improve treatment outcomes.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 20213021.001).
  • [ISSN] 1936-7163
  • [Journal-full-title] Quintessence international (Berlin, Germany : 1985)
  • [ISO-abbreviation] Quintessence Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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69. Matijević M, Leović D, Popić B, Zubcić V, Kopić V, Prlić A, Siber S, Dinjar K: The importance of thorough preoperative diagnostics of maxillary ameloblastoma: report of three cases. Coll Antropol; 2010 Dec;34(4):1445-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The importance of thorough preoperative diagnostics of maxillary ameloblastoma: report of three cases.
  • Ameloblastoma, especially maxillary, is a rare benign neoplasm of odontogenic origin.
  • Diagnosis of significant number of lesions is usually established postoperatively, because ameloblastoma, especially the unicystic form, mimics wide range of more frequent jaw lesions.
  • From January 1993 to December 2005, three cases of the maxillary ameloblastoma were surgically treated at our Department.
  • The authors present clinical, radiological and pathohistological features of the ameloblastomas in this rare localization with special attention to need of accurate preoperative diagnostics.
  • [MeSH-major] Ameloblastoma / diagnosis. Maxillary Neoplasms / diagnosis

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  • (PMID = 21874736.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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70. Sauk JJ, Nikitakis NG, Scheper MA: Are we on the brink of nonsurgical treatment for ameloblastoma? Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jul;110(1):68-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are we on the brink of nonsurgical treatment for ameloblastoma?
  • OBJECTIVE: Recent identification of altered molecular signaling pathways in neoplasia has begun to elucidate mechanisms of oncogenesis, differentiation, and tumor progression, and to suggest plausible nonsurgical considerations for treatment.
  • Here we review the sonic hedgehog (SHH) and PI3K/Akt/mTOR signaling pathways, their role in ameloblastoma, a locally aggressive odontogenic tumor, and evidence for consideration of therapeutic approaches that target these molecular pathways.
  • STUDY DESIGN: This is a comprehensive review of the literature regarding alterations in signaling mechanisms associated with ameloblastomas.
  • In addition, this review attempts to explore and discuss possible inhibitors to these pathways that may have utility in treating ameloblastoma.
  • RESULTS: The expression of SHH signaling molecules in ameloblastomas at the mRNA and protein levels has intimated that these molecules may play a role in cell proliferation of these tumors.
  • Immunohistochemical analysis has revealed aberrant signaling in the PI3K/Akt/mTOR pathway in ameloblastomas and appears to be a valuable tool for elucidating pathogenesis and aggressiveness, and selecting optimal therapeutics.
  • CONCLUSION: The understanding of altered pathways in ameloblastoma may soon provide nonsurgical options for the treatment of this condition.
  • [MeSH-major] Ameloblastoma / drug therapy. Signal Transduction / drug effects

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20418126.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / GLI1 protein, human; 0 / Hedgehog Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / SHH protein, human; 0 / Transcription Factors; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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71. Jiang LJ, Shao CK, He D, Li WG, Wu XZ, Cai DZ: [Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma]. Ai Zheng; 2008 Dec;27(12):1263-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma].
  • BACKGROUND & OBJECTIVE: Matrix metalloproteinases (MMPs) are involved in local invasion of ameloblastomas.
  • This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts.
  • METHODS: EMMPRIN expression and MVD in 41 specimens of ameloblastoma and 40 specimens of odontogenic cyst were examined by SP immuno-histochemistry.
  • RESULTS: EMMPRIN was detected in all specimens of ameloblastomas and odontogenic cysts.
  • The strong positive rate of EMMPRIN was significantly higher in ameloblastomas than in odontogenic cysts (85.4% vs. 62.5%, P<0.05).
  • CONCLUSION: EMMPRIN may play an important role during the progression of ameloblastoma via controlling angiogenesis and degradation of extracellular MMPs.
  • [MeSH-major] Ameloblastoma / metabolism. Antigens, CD147 / metabolism. Jaw Neoplasms / metabolism. Microvessels / pathology

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  • (PMID = 19079990.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 136894-56-9 / Antigens, CD147
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72. de Souza Andrade ES, Miguel MC, de Almeida Freitas R, Pereira Pinto L, Batista de Souza L: Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs. Int J Surg Pathol; 2008 Jul;16(3):277-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoexpression of integrins in ameloblastoma, adenomatoid odontogenic tumor, and human tooth germs.
  • The expression of integrins alpha2beta1, alpha3beta1, and alpha5beta1 in 30 ameloblastomas (20 solid and 10 unicystic tumors), 12 adenomatoid odontogenic tumors (AOTs), and 5 human tooth germs in different stages of odontogenesis was analyzed.
  • No difference in the immunoexpression of the integrins was observed between solid and unicystic ameloblastomas.
  • When these two ameloblastoma types were pooled into a single group, the following significant differences were found: immunoexpression of integrin alpha2beta1 was stronger in ameloblastomas than in AOTs and tooth germs, and the expression of integrin alpha5beta1 was stronger in ameloblastomas than in AOTs.
  • [MeSH-major] Ameloblastoma / metabolism. Biomarkers, Tumor / metabolism. Jaw Neoplasms / metabolism. Receptors, Collagen / metabolism. Tooth Germ / metabolism

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  • (PMID = 18573784.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Integrin alpha2beta1; 0 / Integrin alpha3beta1; 0 / Integrin alpha5beta1; 0 / Receptors, Collagen
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73. Etit D, Uyaroglu MA, Erdogan N: Mixed odontogenic tumor: ameloblastoma and calcifying epithelial odontogenic tumor. Indian J Pathol Microbiol; 2010 Jan-Mar;53(1):122-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed odontogenic tumor: ameloblastoma and calcifying epithelial odontogenic tumor.
  • Odontogenic tumors constitute a group of heterogeneous disease derived from epithelial, mesenchymal and/or ectomesenchymal elements.
  • Ameloblastoma is the best known and the most frequent form of odontogenic tumors.
  • Calcifying epithelial odontogenic tumor (CEOT), known as Pindborg tumor, is locally invasive lesion which has a characteristic amiloid deposition.
  • Here a case of a peripheral ameloblastoma associated with CEOT is presented with clinical and morphological features.
  • [MeSH-major] Ameloblastoma / diagnosis. Ameloblastoma / pathology. Odontogenic Tumors / diagnosis. Odontogenic Tumors / pathology

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  • (PMID = 20090240.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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74. Ramesh RS, Manjunath S, Ustad TH, Pais S, Shivakumar K: Unicystic ameloblastoma of the mandible--an unusual case report and review of literature. Head Neck Oncol; 2010;2:1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unicystic ameloblastoma of the mandible--an unusual case report and review of literature.
  • Ameloblastoma is a true neoplasm of odontogenic epithelial origin.
  • Its incidence, combined with its clinical behavior, makes ameloblastoma the most significant odontogenic neoplasm.
  • Unicystic ameloblastoma (UA) refers to those cystic lesions that show clinical, radiographic, or gross features of a mandibular cyst, but on histologic examination show a typical ameloblastomatous epithelium lining part of the cyst cavity, with or without luminal and/or mural tumor growth.
  • It accounts for 5-15% of all intraosseous ameloblastomas.
  • We report a case of unicystic ameloblastoma in a 30-year-old female, and review the literature.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • [Cites] Int J Oral Maxillofac Surg. 2006 Aug;35(8):681-90 [16782308.001]
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  • (PMID = 20157425.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2821325
  • [General-notes] NLM/ Original DateCompleted: 20100629
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75. Kitkumthorn N, Yanatatsaneejit P, Rabalert J, Dhammawipark C, Mutirangura A: Association of P53 codon 72 polymorphism and ameloblastoma. Oral Dis; 2010 Oct;16(7):631-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of P53 codon 72 polymorphism and ameloblastoma.
  • OBJECTIVE: To test the hypothesis that P53 codon 72 polymorphism was associated with an increased risk of developing ameloblastoma in the Thai population.
  • MATERIALS AND METHODS: Seventy-eight ameloblastomas and 94 healthy controls were genotyped for the P53 codon 72 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • RESULTS: The frequencies of the Arg/Arg, Arg/Pro and Pro/Pro genotypes were 28.72%, 50.00% and 21.28%, respectively, in the controls; and 44.87%, 51.28% and 3.85%, respectively, in ameloblastomas.
  • Therefore, P53 Arg is an ameloblastoma-susceptible allele [OR (95% CI) = 2.06 (1.28-3.31), P = 0.002].
  • Moreover, when compared with homozygous P53 Pro, people who carried the Arg allele had a remarkably high risk of developing ameloblastoma [adjusted OR (95% CI) = 7.26 (2.34-23.41), P < 10(-3)].
  • CONCLUSION: The Arg allele of P53 gene codon 72 may increase susceptibility, and P53 may be important in the aetiology of ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Codon / genetics. Polymorphism, Restriction Fragment Length / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Alleles. Arginine / genetics. Cytosine. Double-Blind Method. Female. Gene Frequency / genetics. Genetic Predisposition to Disease / genetics. Genotype. Guanine. Homozygote. Humans. Male. Polymerase Chain Reaction. Proline / genetics. Sex Factors. Thailand

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  • (PMID = 20412452.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Codon; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; 5Z93L87A1R / Guanine; 8J337D1HZY / Cytosine; 94ZLA3W45F / Arginine; 9DLQ4CIU6V / Proline
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76. Keskin M, Karabekmez FE, Ozkan BT, Tosun Z, Avunduk MC, Savaci N: Simultaneous occurrence of facial fibrous dysplasia and ameloblastoma. J Craniomaxillofac Surg; 2009 Mar;37(2):102-5
Genetic Alliance. consumer health - Fibrous Dysplasia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous occurrence of facial fibrous dysplasia and ameloblastoma.
  • BACKGROUND: Both fibrous dysplasia (FD) and ameloblastoma are benign but locally aggressive tumours of the craniofacial region.
  • She was diagnosed as FD of the maxilla, temporal bone and sphenoid sinus together with ameloblastoma of the mandible after surgery and histopathological evaluation.
  • CONCLUSION: The case that we present here is unique in that two separate pathological conditions, FD of the upper face, and ameloblastoma of the mandible coexisted.
  • Although cases of synchronous or metachronous occurrence of FD and ameloblastoma with other pathology have been previously described, this to our knowledge, is the first reported case of true coexistence of FD and ameloblastoma.
  • [MeSH-major] Ameloblastoma / complications. Fibrous Dysplasia, Monostotic / complications. Mandibular Neoplasms / complications. Maxillary Diseases / complications

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  • (PMID = 19064325.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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77. Thillaikarasi R, Balaji J, Gupta B, Ilayarja V, Vani NV, Vidula B, Saravanan B, Ponniah I: Cystic granular cell ameloblastoma. J Maxillofac Oral Surg; 2010 Sep;9(3):310-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic granular cell ameloblastoma.
  • Ameloblastoma is a locally aggressive benign epithelial odontogenic tumor, while unicystic ameloblastoma is a relatively less aggressive variant.
  • Although rare in unicystic or cystic ameloblastoma, granular cell change in ameloblastoma is a recognized phenomenon.
  • The purpose of the present article is to report a case of cystic granular cell ameloblastoma in 34-year old female.

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  • (PMID = 22190813.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3177435
  • [Keywords] NOTNLM ; Ameloblastoma / Cystic / Granular cell / Odontogenic
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78. Adebiyi KE, Ugboko VI, Omoniyi-Esan GO, Ndukwe KC, Oginni FO: Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med; 2006;2:42

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population.
  • BACKGROUND: This study was carried out to establish the relative incidence and provide clinico-pathologic information on the various histological types of ameloblastoma seen at the Obafemi Awolowo University Teaching Hospital complex, Ile-Ife in order to provide a baseline data which will be of significance to the pathologist and clinician.
  • METHODS: Clinico-pathologic data on a total of 77 histologically diagnosed cases of ameloblastoma archieved at the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife over a 15 year period were obtained and analysed descriptively.
  • RESULTS: Follicular ameloblastoma was the most common histological type (50 cases, 64.9%), followed by plexiform ameloblastoma (10 cases, 13.0%).
  • 4 (5.2%) cases of desmoplastic and 3 (3.9%) cases of acanthomatous ameloblastoma were seen while the basal cell variant accounted for 2 (2.6%) cases.
  • Ameloblastoma occurred over an age range of 11 to 70 years with a peak age incidence in the 3rd decade.
  • CONCLUSION: This study provides a baseline data on variants of ameloblastoma as obtained in a suburban Nigerian population.
  • Since variants of ameloblastoma differ in biologic behaviour, the data collected in this study provides clinicopathologic information which is of significance to the pathologist and clinician.
  • [MeSH-major] Ameloblastoma / pathology. Jaw Neoplasms / pathology. Suburban Population

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  • [Cites] Oral Surg Oral Med Oral Pathol. 1967 Sep;24(3):392-403 [5233386.001]
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  • (PMID = 17125498.001).
  • [ISSN] 1746-160X
  • [Journal-full-title] Head & face medicine
  • [ISO-abbreviation] Head Face Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1675998
  • [General-notes] NLM/ Original DateCompleted: 20070724
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79. Lim J, Ahn H, Min S, Hong SD, Lee JI, Hong SP: Oligonucleotide microarray analysis of ameloblastoma compared with dentigerous cyst. J Oral Pathol Med; 2006 May;35(5):278-85

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oligonucleotide microarray analysis of ameloblastoma compared with dentigerous cyst.
  • BACKGROUND: Ameloblastoma is a benign, but locally invasive tumor known for its high rate of recurrence.
  • Our aim was to identify possible genes involved in the development and progression of ameloblastoma, using microarray analysis with dentigerous cyst as a control.
  • METHODS: Total RNA was extracted from two fresh dentigerous cysts and ameloblastoma specimens.
  • CONCLUSIONS: We identified important genes related to the development and progression of ameloblastoma through a large-scale gene expression analysis.
  • This study will stimulate further investigations on genes significant for early diagnosis and prognosis of ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Dentigerous Cyst / genetics. Mandibular Neoplasms / genetics

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  • (PMID = 16630291.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Neoplasm
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80. Qian Y, Huang HZ: The role of RANKL and MMP-9 in the bone resorption caused by ameloblastoma. J Oral Pathol Med; 2010 Sep;39(8):592-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of RANKL and MMP-9 in the bone resorption caused by ameloblastoma.
  • BACKGROUND: Ameloblastoma, a common odontogenic tumor located in jaws, generally leads to severe damage to patient's complexion and masticatory function.
  • To expand in jaws, ameloblastoma must have a mechanism of resorbing the surrounding bone.
  • Our objective was to explore the bone-resorption mechanism of ameloblastoma by observing the role of Receptor activator of nuclear factor kappa B ligand (RANKL) and matrix metalloproteinase-9 (MMP-9) in the bone-resorption process.
  • METHODS: In the study, the expression of RANKL and MMP-9 in ameloblastoma was detected using immunohistochemistry (IHC) and RT-PCR.
  • Then, co-culture system of ameloblastoma cells and bone marrow cells from neonatal rabbit was erected to observe the potential of ameloblastoma cells to induce osteoclastogenesis.
  • RESULTS: The expression of RANKL and MMP-9 in ameloblastoma was confirmed.
  • Ameloblastoma cells were found to induce bone marrow cells from neonatal rabbit differentiate into osteoclasts with bone-resorption activity.
  • CONCLUSIONS: Ameloblastoma cells had the potential to induce osteoclastogenesis.
  • Moreover, RANKL played an essential role in the in vitro osteoclast formation and bone resorption induced by ameloblastoma cells.
  • [MeSH-major] Ameloblastoma / complications. Bone Resorption / etiology. Matrix Metalloproteinase 9 / physiology. RANK Ligand / physiology

  • Hazardous Substances Data Bank. CALCIUM, ELEMENTAL .
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  • [Copyright] © 2010 John Wiley & Sons A/S.
  • (PMID = 20412401.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Isoenzymes; 0 / Matrix Metalloproteinase Inhibitors; 0 / Osteoprotegerin; 0 / RANK Ligand; 0 / TNFSF11 protein, human; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.1.3.- / tartrate-resistant acid phosphatase; EC 3.1.3.2 / Acid Phosphatase; EC 3.4.24.35 / Matrix Metalloproteinase 9; SY7Q814VUP / Calcium
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81. Sham E, Leong J, Maher R, Schenberg M, Leung M, Mansour AK: Mandibular ameloblastoma: clinical experience and literature review. ANZ J Surg; 2009 Oct;79(10):739-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mandibular ameloblastoma: clinical experience and literature review.
  • BACKGROUND: Ameloblastoma is a locally aggressive odontogenic tumour of the mandible and maxilla that, if neglected, can cause severe facial disfigurement and functional impairment.
  • A thorough understanding of its clinicopathological behaviour is essential to avoid recurrence associated with inadequately treated disease.
  • Currently, wide resection and immediate reconstruction is the treatment of choice in most cases of mandibular ameloblastoma.
  • We present our experience in the management of this disease and review the current status of the literature.
  • METHOD: Retrospective review of all patients between 1996 and 2006 with histologically confirmed ameloblastoma.
  • A literature review on the current understanding of this disease and its management is then presented.
  • CONCLUSION: Management of ameloblastoma remains a challenge and requires a thorough understanding of the behaviour of its different clinicopathological variants.
  • [MeSH-major] Ameloblastoma. Mandibular Neoplasms

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  • (PMID = 19878171.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Number-of-references] 42
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82. Belli E, Rendine G, Mazzone N: Ameloblastoma relapse after 50 years from resection treatment. J Craniofac Surg; 2009 Jul;20(4):1146-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma relapse after 50 years from resection treatment.
  • Ameloblastoma is a slow-growing, locally invasive, epithelial odontogenic tumor of the jaws with a high rate of recurrence if not removed adequately but with virtually no tendency to metastasize (World Health Organization Classification of Tumors: Pathology and Genetics of Head and Neck Tumours, 2005).
  • This paper presents a case of a woman who was treated in 1961, when she was 25 years old, for an ameloblastoma in the right posterior region of the mandible.
  • After 50 years, the ameloblastoma relapsed, and another surgical treatment was necessary.
  • [MeSH-major] Ameloblastoma / pathology. Ameloblastoma / surgery. Mandibular Neoplasms / pathology. Mandibular Neoplasms / surgery. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery

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  • (PMID = 19553848.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Jeblaoui Y, Ben Neji N, Haddad S, Ouertatani L, Hchicha S: [Algorithm for the treatment of ameloblastoma in Tunisia]. Rev Stomatol Chir Maxillofac; 2007 Nov;108(5):419-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Algorithm for the treatment of ameloblastoma in Tunisia].
  • INTRODUCTION: Ameloblastoma is a benign but locally aggressive and infiltrative odontogenic neoplasm.
  • Numerous methods of treatment have been proposed but the latest studies showed that a radical treatment is the recommended protocol for the surgical management of ameloblastomas.
  • The purpose of this study was to review the clinical features and surgical treatment of ameloblastomas treated in our department and to propose an algorithm for the treatment adapted to our country.
  • Data with respect to the patients' ages, sex, tumor locations, and surgical treatment history, as well as radiographic findings and number of recurrences, was analyzed.
  • Sixty-two percent of ameloblastomas were located in the mandibular angle.
  • [MeSH-major] Ameloblastoma / surgery. Mandibular Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Oral Surgical Procedures / methods

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  • (PMID = 17572460.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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84. Correnti M, Rossi M, Avila M, Perrone M, Rivera H: Human papillomavirus in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Sep;110(3):e20-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus in ameloblastoma.
  • OBJECTIVE: Ameloblastomas are benign epithelial tumors of odontogenic origin, with a high recurrence rate and local aggressiveness.
  • A few preliminary studies have demonstrated HPV presence mainly in peripheral ameloblastomas.
  • The purpose of this study was to detect HPV-DNA in intraosseous ameloblastomas.
  • METHODS: Eighteen cases of intraosseous ameloblastomas of different histological variants were selected.
  • Four of the unicystic ameloblastomas were HPV positive; of these, all presented koilocytic changes and were associated with dentigerous cysts, whereas only 2 positive cases corresponded to solid ameloblastomas.
  • CONCLUSIONS: We may conclude that HPV low and high risk was detected in our sample of intraosseous ameloblastomas.
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Ameloblastoma / virology. Mandibular Neoplasms / virology. Papillomavirus Infections / diagnosis

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20727492.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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85. Kawabata T, Takahashi K, Sugai M, Murashima-Suginami A, Ando S, Shimizu A, Kosugi S, Sato T, Nishida M, Murakami K, Iizuka T: Polymorphisms in PTCH1 affect the risk of ameloblastoma. J Dent Res; 2005 Sep;84(9):812-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Polymorphisms in PTCH1 affect the risk of ameloblastoma.
  • Ameloblastoma is the most common odontogenic tumor, but the genetic nature of the changes in the tumor cells has been unclear.
  • Both CTNNB1 and PTCH1 are important in tooth development and are expressed in ameloblastoma.
  • The aim of this study was to investigate whether genetic alterations of CTNNB1 and PTCH1 are present in ameloblastoma.
  • We investigated 14 cases of ameloblastoma.
  • The polymorphisms found in the ameloblastoma patients were further examined in a subsequent case-control study.
  • We found a CTNNB1 mutation in one case of plexiform-type ameloblastoma.
  • The proportion of CGG8 alleles was significantly higher in the ameloblastoma group.
  • The results of this study indicate a possible relationship between the CGG8 allele in PTCH1 and the risk for ameloblastoma.
  • [MeSH-major] Ameloblastoma / genetics. Receptors, Cell Surface / genetics

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  • (PMID = 16109989.001).
  • [ISSN] 0022-0345
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / PTCH protein, human; 0 / Patched Receptors; 0 / Patched-1 Receptor; 0 / Receptors, Cell Surface; 0 / Trans-Activators; 0 / beta Catenin
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86. Ide F, Mishima K, Miyazaki Y, Saito I, Kusama K: Peripheral ameloblastoma in-situ: an evidential fact of surface epithelium origin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Nov;108(5):763-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral ameloblastoma in-situ: an evidential fact of surface epithelium origin.
  • The proposed origin from the adult gingival epithelium for peripheral ameloblastoma is difficult to prove and still remains unresolved.
  • In addition to the morphologic overlap, early ameloblastoma epithelia shared antigenic properties with tumor cells of representative control examples of peripheral ameloblastoma.
  • This is the first description of an in situ lesion of peripheral ameloblastoma, to our knowledge, and its multifocal ameloblastoma changes can be accepted as a direct proof of origin from the surface epithelium.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Neoplasms / pathology

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  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May;109(5):655-6; author reply 656-7 [20416531.001]
  • (PMID = 19748296.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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87. Sun ZJ, Wu YR, Cheng N, Zwahlen RA, Zhao YF: Desmoplastic ameloblastoma - A review. Oral Oncol; 2009 Sep;45(9):752-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoplastic ameloblastoma - A review.
  • Among the ameloblastomas, the desmoplastic variation is rare.
  • The desmoplastic ameloblastoma (DA) is characterized by specific clinical, imaging, and histological features.
  • In conclusion, these retrospective results confirm the statement that DA is a variation among ameloblastomas.
  • DA present clinicoradiographic and histologic distinct features, when compared with "conventional ameloblastomas".
  • [MeSH-major] Ameloblastoma / epidemiology. Mandibular Neoplasms / epidemiology. Maxillary Neoplasms / epidemiology

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  • (PMID = 19631576.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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88. Smullin SE, Faquin W, Susarla SM, Kaban LB: Peripheral desmoplastic ameloblastoma: report of a case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Jan;105(1):37-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral desmoplastic ameloblastoma: report of a case and literature review.
  • The desmoplastic variant of ameloblastoma is a rare, locally invasive, benign tumor of the jaws, typically found in the anterior regions of the maxilla and mandible.
  • This ameloblastoma variant has been described as an intraosseous tumor; to our knowledge, there have been no published cases of a peripheral desmoplastic ameloblastoma.
  • The purpose of this case report is to describe a patient with a desmoplastic ameloblastoma localized to the soft tissue of the palate with no osseous involvement.
  • [MeSH-major] Ameloblastoma / pathology. Palatal Neoplasms / pathology

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  • (PMID = 17764981.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 14
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89. Rastogi V, Pandilwar PK, Maitra S: Ameloblastoma: an evidence based study. J Maxillofac Oral Surg; 2010 Jun;9(2):173-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ameloblastoma: an evidence based study.
  • OBJECTIVE: The purpose of this study is to present a series of 46 cases of ameloblastoma-38 in mandible and 8 in maxilla treated in the Oral and Maxillofacial Surgery Department of Government Dental College and Hospital, Nagpur during 1997-2006 with emphasis on various treatment modalities used in treating different types of ameloblastoma and how to define the safe margin for different clinical and histopathological types of ameloblastoma with their follow-up.
  • RESULT: In a follow-up period of 1-9 years recurrence was observed in six cases, two in patients treated with enucleation and curettage, three in patients treated with segmental resection and one in patient with peripheral ameloblastoma treated with soft tissue resection.

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  • (PMID = 22190781.001).
  • [ISSN] 0974-942X
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3244084
  • [Keywords] NOTNLM ; Ameloblastoma / Biopsy / Malignant / Mandible / Multicystic
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90. Yavagal C, Anegundi RT, Shetty S: Unicystic plexiform ameloblastoma: an insight for pediatric dentists. J Indian Soc Pedod Prev Dent; 2009 Jan-Mar;27(1):70-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unicystic plexiform ameloblastoma: an insight for pediatric dentists.
  • Ameloblastomas have been categorized broadly into three biologic variants: cystic (unicystic), solid, and peripheral.
  • The term plexiform unicystic ameloblastoma refers to a pattern of epithelial proliferation that has been described in cystic lesions of the jaws.
  • Although the histology suggests that cystic ameloblastomas follow a biologically low-grade course, recent evidence suggests that they may often behave clinically as biologically aggressive tumors.
  • A literature review on the topic has been added along with a case report highlighting the state-of-the-art approach and management of such ameloblastomas, in pediatric patients.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology

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  • (PMID = 19414980.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 14
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91. Fregnani ER, da Cruz Perez DE, Soares FA, Alves FA: Synchronous ameloblastoma and orthokeratinized odontogenic cyst of the mandible. J Oral Pathol Med; 2006 Oct;35(9):573-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous ameloblastoma and orthokeratinized odontogenic cyst of the mandible.
  • The simultaneous occurrence of ameloblastomas with odontogenic cysts or other non-odontogenic lesions have already been described as combined lesions.
  • However, we are unaware of any report in the English literature of simultaneous occurrence of ameloblastoma and orthokeratinized odontogenic cyst (OOC) occurring as completely distinct lesions.
  • This report shows a case of synchronous ameloblastoma and OOC, located on posterior regions of the mandible, but in distinct sides.
  • [MeSH-major] Ameloblastoma / diagnosis. Mandibular Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Odontogenic Cysts / diagnosis

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  • (PMID = 16968239.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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92. Ereño C, Etxegarai L, Corral M, Basurko JM, Bilbao FJ, López JI: Primary sinonasal ameloblastoma. APMIS; 2005 Feb;113(2):148-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary sinonasal ameloblastoma.
  • A case of primary ameloblastoma of the right sinonasal tract in a 66-year-old man is reported.
  • [MeSH-major] Ameloblastoma / pathology. Nose Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 15723691.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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93. LeCorn DW, Bhattacharyya I, Vertucci FJ: Peripheral ameloblastoma: a case report and review of the literature. J Endod; 2006 Feb;32(2):152-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral ameloblastoma: a case report and review of the literature.
  • Peripheral ameloblastoma is a rare, benign odontogenic tumor that histologically resembles an intraosseous ameloblastoma but develops in the soft tissues of the gingiva and mucosa and exhibits an innocuous clinical behavior.
  • We report a case of a recurrent peripheral ameloblastoma in a 61-year-old man that presented as a painless swelling on the maxillary anterior labial attached gingiva.
  • The peripheral ameloblastoma should be included in the differential diagnosis of a gingival lesion clinically resembling any of the myriads of entities seen on the gingiva including a pyogenic granuloma, peripheral giant cell granuloma, or parulis/gumboil.
  • [MeSH-major] Ameloblastoma / pathology. Gingival Neoplasms / pathology

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  • (PMID = 16427467.001).
  • [ISSN] 0099-2399
  • [Journal-full-title] Journal of endodontics
  • [ISO-abbreviation] J Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 11
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94. Vanoven BJ, Parker NP, Petruzzelli GJ: Peripheral ameloblastoma of the maxilla: a case report and literature review. Am J Otolaryngol; 2008 Sep-Oct;29(5):357-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral ameloblastoma of the maxilla: a case report and literature review.
  • Peripheral ameloblastoma is a rare, benign, extraosseous neoplasm of the odontogenic epithelium.
  • We report a case of peripheral ameloblastoma, detail our surgical therapy and review important elements in the pathological diagnosis and treatment of this unusual neoplasm.
  • [MeSH-major] Ameloblastoma / pathology. Ameloblastoma / surgery. Maxillary Neoplasms / pathology. Maxillary Neoplasms / surgery

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  • (PMID = 18722894.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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95. Kumamoto H, Ohki K: Detection of Notch signaling molecules in ameloblastomas. J Oral Pathol Med; 2008 Apr;37(4):228-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Detection of Notch signaling molecules in ameloblastomas.
  • BACKGROUND: To evaluate the roles of Notch signaling in the oncogenesis and cytodifferentiation of odontogenic tumors, expression of Notch receptors and ligands was analyzed in ameloblastomas as well as in tooth germs.
  • METHODS: Tissue specimens of nine tooth germs and 32 ameloblastomas were examined by reverse transcriptase polymerase chain reaction and by in situ hybridization to determine the expression of Notch1, Notch2, Notch3, Delta1, and Jagged1.
  • Ameloblastomas showed expression of Notch receptors and ligands in central polyhedral neoplastic cells.
  • Expression of Notch receptors and ligands was not found in keratinizing cells or granular cells in ameloblastoma variants.
  • CONCLUSION: Expression of Notch receptors and ligands in tooth germs and ameloblastomas suggests that Notch signaling might control cell differentiation and proliferation of normal and neoplastic odontogenic epithelium.
  • [MeSH-major] Ameloblastoma / chemistry. Intercellular Signaling Peptides and Proteins / analysis. Jaw Neoplasms / chemistry. Receptors, Notch / analysis. Tooth Germ / chemistry

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  • (PMID = 18221321.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Intercellular Signaling Peptides and Proteins; 0 / RNA, Messenger; 0 / Receptors, Notch
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96. Sukarawan W, Simmons D, Suggs C, Long K, Wright JT: WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviors. Am J Pathol; 2010 Jan;176(1):461-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] WNT5A expression in ameloblastoma and its roles in regulating enamel epithelium tumorigenic behaviors.
  • In this study we demonstrated that WNT5A expression was intense in both the epithelial component of ameloblastomas, the most common epithelial odontogenic tumor, and in this tumor's likely precursor cell, the enamel epithelium located at the cervical loop of normal developing human tooth buds.
  • Additionally, when WNT5A was overexpressed in enamel epithelium cells (LS-8), the clones expressing high levels of WNT5A (S) exhibited characteristics of tumorigenic cells, including growth factor independence, loss of anchorage dependence, loss of contact inhibition, and tumor formation in immunocompromised mice.
  • Taken together, our data indicate that WNT5A signaling is important in modulating tumorigenic behaviors of enamel epithelium cells in ameloblastomas.

  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
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  • (PMID = 20008136.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / DE533921
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Proto-Oncogene Proteins; 0 / WNT5A protein, human; 0 / Wnt Proteins; 0 / Wnt5a protein, mouse
  • [Other-IDs] NLM/ PMC2797904
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97. Maria A, Sharma Y: Granular cell - Peripheral ameloblastoma: a rare variant. J Maxillofac Oral Surg; 2009 Sep;8(3):294-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell - Peripheral ameloblastoma: a rare variant.
  • Ameloblastoma is an epithelial odontogenic tumour of the jaw and exhibits diverse microscopic patterns which occurs either singly or in combination with other patterns.
  • Peripheral ameloblastoma is a rare odontogenic soft tissue tumor, derived from epithelial and/or mesenchymal elements being part of the tooth-forming apparatus.
  • The lesions responsible for approximately 1% to 5% of all cases of ameloblastoma affecting alveolar mucosa and gingiva occurring mainly, in the middle age.
  • This article describes a case of peripheral ameloblastoma affecting a 35-year-old female.
  • The occurrence and pathogenesis of peripheral ameloblastomas in general, are reviewed.

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  • (PMID = 23139530.001).
  • [ISSN] 0972-8279
  • [Journal-full-title] Journal of maxillofacial and oral surgery
  • [ISO-abbreviation] J Maxillofac Oral Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3454237
  • [Keywords] NOTNLM ; Granular cell ameloblastoma / Peripheral ameloblastoma
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98. Punnya AV, Rekha K: "Ameloblastoma with mucous cells": review of literature and presentation of 2 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Dec;106(6):e20-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Ameloblastoma with mucous cells": review of literature and presentation of 2 cases.
  • Ameloblastoma, a relatively rare benign odontogenic tumor; originates from the odontogenic epithelium and has been studied extensively for its unique clinicopathologic features.
  • The occurrence of mucous cells in ameloblastoma is an exceptionally rare phenomenon and to date only 4 well established cases have been reported.
  • In the present paper, 2 more cases of ameloblastoma showing evidence of mucous cells are reported, along with a review of pertinent literature.
  • A brief clinicopathologic analysis of all the reported cases, an insight into possible histogenesis of these cells in ameloblastoma, and diagnostic difficulties encountered due to this finding are also discussed.
  • An interesting finding in our review is that all of the the cases of ameloblastoma exhibiting mucous cells occurred in the anterior region of the jaw with a predilection to mandible.
  • [MeSH-major] Ameloblastoma / pathology. Mandibular Neoplasms / pathology. Maxillary Neoplasms / pathology

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  • (PMID = 19000605.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Mucins
  • [Number-of-references] 28
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99. Montoro JR, Tavares MG, Melo DH, Franco Rde L, Mello-Filho FV, Xavier SP, Trivellato AE, Lucas AS: Mandibular ameloblastoma treated by bone resection and immediate reconstruction. Braz J Otorhinolaryngol; 2008 Jan-Feb;74(1):155-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mandibular ameloblastoma treated by bone resection and immediate reconstruction.
  • Multicystic ameloblastoma mainly affects adult patients between the third and seventh decades of life, frequently in the posterior region of the mandible.
  • The objective of this study is to show that multidisciplinary treatment of ameloblastomas helps in total lesion excision associated with complete reconstruction of the damaged area.
  • We present a 47-year-old male patient with an ameloblastoma in the posterior mandible who was treated with complete resection of a mandibular segment.
  • [MeSH-major] Ameloblastoma / surgery. Dental Implantation, Endosseous. Mandibular Neoplasms / surgery

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  • (PMID = 18392519.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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100. Muvova L, Dilu N, Sokolo M: [The treatment of choice for recurrent ameloblastoma]. Odontostomatol Trop; 2005 Jun;28(110):13-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The treatment of choice for recurrent ameloblastoma].
  • 92 patients with recurring ameloblastoma of jawbones were followed.
  • What implies that the preserving surgery on the recurring ameloblastoma is more beneficial than negative with the two races with more than 80%.
  • The authors thus concluded that this surgical method still keeps its place of choice in the treatment of the repetitions of the ameloblastoma and that this factor has a prognostic value.
  • [MeSH-major] Ameloblastoma / surgery. Jaw Neoplasms / surgery. Neoplasm Recurrence, Local / surgery

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  • (PMID = 16245761.001).
  • [ISSN] 0251-172X
  • [Journal-full-title] Odonto-stomatologie tropicale = Tropical dental journal
  • [ISO-abbreviation] Odontostomatol Trop
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Senegal
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