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1. Castillo O, Frisancho O, Palomino A: [Cecal amelanotic melanoma]. Rev Gastroenterol Peru; 2010 Oct-Dec;30(4):368-71
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  • [Title] [Cecal amelanotic melanoma].
  • [Transliterated title] Melanoma amelanótico en ciego.
  • Subsequently, we confirmed the presence of red blood in stools, like enterorrhagia and underwent a colonoscopy, in which two elevated lesions were found in the cecum: a pedunculated (with active bleeding, oozing) and other sessile; both were removed. the pathology showed that corresponded to amelanotic melanoma in cecal region.
  • Physical examination revealed no malignant skin lesions.
  • We report this case, because gastrointestinal bleeding is an unusual clinical presentation of malignant melanoma.
  • [MeSH-major] Cecal Neoplasms / pathology. Melanoma / pathology

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  • (PMID = 21263766.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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2. Zielińska K, Kozłowska K, Cichorek M, Wachulska M: Fas and FasL expression on cells of two transplantable melanoma lines according to their different biological properties. Folia Histochem Cytobiol; 2008;46(3):337-43
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  • [Title] Fas and FasL expression on cells of two transplantable melanoma lines according to their different biological properties.
  • In tumours (e.g. melanoma), FasL expression possibly counteracts the Fas-positive effector T cells that infiltrate into tumours, and consequently the Fas/FasL interaction can contribute to the escape of tumour cells from the systemic immune response.
  • In this study we examined differences in Fas and FasL expression on cells from the hamster melanotic melanoma line (Ma) and a more aggressive amelanotic melanoma line (Ab).
  • We also tried to find out whether the Fas/FasL expression induces an ability to undergo spontaneous apoptosis in these two transplantable melanoma lines.
  • Isolated transplantable melanoma cells were incubated for 4 and 24 hours and after that time the expression of Fas and FasL was estimated by flow cytometry.
  • The results show that there was no Fas expression, although FasL was detected on both melanoma cell lines.
  • Therefore the data reported by other authors indicate that a lack or a low level of Fas expression and an ectopic expression of FasL on melanoma cells can be an escape mechanism of the tumour, to avoid host immune responses.
  • The content of FasL-positive melanotic melanoma cells was higher than in amelanotic melanoma cells and increased with the prolongation of the incubation time.
  • FasL expression on amelanotic melanoma cells was detected after 24 hours at a level similar to that on melanotic melanoma cells after 4 hours incubation time.
  • FasL expression on melanoma cells can induce apoptosis in cytotoxic T lymphocytes and NK cells which are responsible for tumour cells elimination.
  • The results obtained suggest that the Fas/FasL system does not play any significant role in spontaneous apoptosis of two melanoma cell lines.

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  • (PMID = 19056538.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Fas Ligand Protein
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3. Dubrey S, Grocott-Mason R, Mittal T, Burke M: Massive cardiac invasion by amelanotic melanoma with obstructive clinical features. Postgrad Med J; 2008 Mar;84(989):163-6
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  • [Title] Massive cardiac invasion by amelanotic melanoma with obstructive clinical features.
  • Reports of malignant melanoma involving the heart usually describe metastatic spread of pigmented (melanotic) forms of this tumour.
  • The case is unusual in relation to the extreme size of this amelanotic melanoma at presentation and the fact that it appears to be a solitary metastasis.
  • [MeSH-major] Cardiac Tamponade / etiology. Heart Neoplasms / secondary. Melanoma, Amelanotic / secondary. Skin Neoplasms

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  • (PMID = 18372490.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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4. Nejc D, Piekarski J, Pasz-Walczak G, Wroński K, Pluta P, Jeziorski A: The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. Melanoma Res; 2005 Dec;15(6):565-9
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  • [Title] The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis.
  • We present the first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis.
  • Pathologic examination of the postoperative specimen revealed the presence of a very rare malignancy--amelanotic melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Penile Neoplasms / pathology

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  • (PMID = 16314746.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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5. Langmann G, Lechner H, Wenzel E, Mossböck G, Wackernagel W: [Transpupillary thermotherapy (TTT) for uveal melanomas. Long term results of a single TTT with an adapter for a conventional infrared laser]. Ophthalmologe; 2005 Dec;102(12):1162-7
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  • [Title] [Transpupillary thermotherapy (TTT) for uveal melanomas. Long term results of a single TTT with an adapter for a conventional infrared laser].
  • PATIENTS AND METHOD: Among 18 eyes, 10 tumors were classified as small, and 8 as medium sized (with a maximum prominence of 5.6 mm): 5 melanomas had a juxtapapillary location, 6 a macular (or juxtamacular) location, and 7 were located in the midperiphery of the fundus.
  • Amelanotic melanomas and macular melanomas seem to respond poorly to thermotherapy.
  • [MeSH-major] Hyperthermia, Induced / instrumentation. Hyperthermia, Induced / methods. Infrared Rays / therapeutic use. Laser Therapy. Melanoma / therapy. Uveal Neoplasms / therapy

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  • (PMID = 15947964.001).
  • [ISSN] 0941-293X
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
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6. Pizzichetta MA, Canzonieri V, Massarut S, Baresic T, Borsatti E, Menzies SW: Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. J Am Acad Dermatol; 2010 May;62(5):893-4
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  • [Title] Pitfalls in the dermoscopic diagnosis of amelanotic melanoma.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • [CommentOn] J Am Acad Dermatol. 2007 Mar;56(3):508-13 [17113189.001]
  • (PMID = 20398822.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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7. Chen KG, Szakács G, Annereau JP, Rouzaud F, Liang XJ, Valencia JC, Nagineni CN, Hooks JJ, Hearing VJ, Gottesman MM: Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Res; 2005 Apr;18(2):102-12
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  • [Title] Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta ) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes.
  • We identified and cloned two novel mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ABC transporter ABCB 5 in human melanoma cells.
  • We found that the melanomas included among the NCI-60 panel of cell lines preferentially expressed both ABCB 5alpha and ABCB 5beta.
  • However, ABCB 5alpha/beta expression was undetectable in two amelanotic melanomas (M14 and LOX-IMVI).
  • The expression profile of ABCB 5alpha/beta in all of the other melanomas of the panel was confirmed both by RT-PCR and by sequencing.
  • Our findings indicate that expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas.

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  • (PMID = 15760339.001).
  • [ISSN] 0893-5785
  • [Journal-full-title] Pigment cell research
  • [ISO-abbreviation] Pigment Cell Res.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / Z99 NS999999
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / ABCB5 protein, human; 0 / Biomarkers, Tumor; 0 / P-Glycoprotein; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS318566; NLM/ PMC3915408
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8. An J, Li B, Wu L, Lu H, Li N: Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res; 2009 Aug;19(4):267-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature.
  • Primary amelanotic melanoma of the female genital tract usually has a poor outcome as a consequence of delayed diagnosis and lack of standardized treatment.
  • We report two cases of this disease originating in the vulva and uterine cervix, respectively.
  • Compared with amelanotic melanoma of the female genital tract of the vulva, disease of the cervix is more likely to be misdiagnosed, identified at a later stage, and have a poorer outcome.
  • [MeSH-major] Melanoma, Amelanotic. Uterine Cervical Neoplasms. Vulvar Neoplasms


9. LeRoy BE, Knight MC, Eggleston R, Torres-Velez F, Harmon BG: Tail-base mass from a "horse of a different color". Vet Clin Pathol; 2005;34(1):69-71
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  • The cytologic and histopathologic diagnoses were amelanotic melanoma.
  • In this report, we describe the cytopathologic features of an aggressive amelanotic melanoma in a non-grey horse and emphasize the unique correlation between cytologic and histologic findings.

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  • (PMID = 15732023.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Camerin M, Magaraggia M, Soncin M, Jori G, Moreno M, Chambrier I, Cook MJ, Russell DA: The in vivo efficacy of phthalocyanine-nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma. Eur J Cancer; 2010 Jul;46(10):1910-8
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  • [Title] The in vivo efficacy of phthalocyanine-nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma.
  • The efficiency of a Zn(II)-phthalocyanine disulphide (C11Pc), a compound with both phthalocyanine units bearing seven hexyl chains and a sulphur terminated C11 chain, as a photodynamic therapy (PDT) agent was investigated in C57 mice bearing a sub-cutaneously transplanted amelanotic melanoma.
  • Biodistribution studies at selected post-injection times showed that the nanoparticle-associated C11Pc was recovered in significantly larger amounts from all the examined tissues and the serum and yielded a greater selectivity of tumour targeting: thus, the ratio between the amount of phthalocyanine recovered from the amelanotic melanoma and the skin (peritumoural tissue) increased from 2.3 to 5.5 from the free to the gold nanoparticle-bound C11Pc at 24 h after injection.
  • PDT studies with the C11Pc-loaded amelanotic melanoma showed a markedly more significant response of the tumour in the mice that had received the nanoparticle-bound photosensitiser; the PDT effect was especially extensive if the irradiation was performed at 3h after C11Pc injection when large phthalocyanine amounts were still present in the serum.
  • [MeSH-major] Indoles / therapeutic use. Melanoma, Amelanotic / drug therapy. Metal Nanoparticles / therapeutic use. Organometallic Compounds / therapeutic use. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20356732.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / C22031/A7097
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Indoles; 0 / Organometallic Compounds; 0 / Photosensitizing Agents; 14320-04-8 / Zn(II)-phthalocyanine
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11. Ohata Y, Haga T, Ogata S, Nakanishi K, Kawai T: Malignant amelanotic melanoma of the pleura without primary skin lesion:an autopsy case report. Acta Med Okayama; 2009 Dec;63(6):379-84
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  • [Title] Malignant amelanotic melanoma of the pleura without primary skin lesion:an autopsy case report.
  • Melanoma metastasizing to the lungs is common, but primary pulmonary or pleural melanoma is extremely rare.
  • We present an autopsy case of malignant melanoma of the pleura without primary skin lesion in a 49-year-old man.
  • At autopsy, a yellow-white tumor located primarily in the right visceral pleura (diagnosed as an amelanotic melanoma) was found to have invaded into the right lung, right parietal pleura, and right diaphragm, and to have metastasized into the left lung and visceral pleura, thyroid, and left adrenal gland.
  • Immuno-histochemical examination for S100 and HMB-45 would thus appear to be useful for the diagnosis of an amelanotic melanoma.
  • [MeSH-major] Lung Neoplasms. Melanoma, Amelanotic. Pleura / pathology. Skin Neoplasms

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  • (PMID = 20035295.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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12. de Almeida LS, Requena L, Rütten A, Kutzner H, Garbe C, Pestana D, Gomes MM: Desmoplastic malignant melanoma: a clinicopathologic analysis of 113 cases. Am J Dermatopathol; 2008 Jun;30(3):207-15
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  • [Title] Desmoplastic malignant melanoma: a clinicopathologic analysis of 113 cases.
  • Desmoplastic melanoma (DM) is a rare variant of spindle cell melanoma, which usually develops in sun-damaged skin of elderly patients.
  • Malignant melanoma was the initial clinical diagnosis in only 27% of the cases.
  • Fifty-one cases (45%) were classified as "pure DM" when the lesion was entirely desmoplastic, and 62 cases (55%) were considered as "combined DM" when a recognizable desmoplastic component was seen in an otherwise conventional malignant melanoma.
  • In 81% of the cases, an atypical intraepidermal melanocytic component (in situ malignant melanoma) was identified, whereas in the remaining 19% of the cases the intraepidermal component was lacking.
  • Seventy-one percent of the cases were histologically amelanotic, 23% showed a small amount of pigment, and only 6% were heavily pigmented.
  • On follow-up, 55/113 patients (49%) (with an average of 55 months) demonstrated persistence of the disease.
  • About 4% had local recurrences, 2% of lymph node invasion, 9% systemic metastases, and 12% died from the disease (2 cases of pure DM and 5 cases of combined DM).
  • Although a better prognosis has been postulated for DM when compared with conventional cutaneous malignant melanomas of the same thickness, in most cases, a DM is diagnosed only in established long-standing and thick melanomas.
  • Therefore, dermatologists and dermatopathologists should be more aware of this clinicopathologic variant of cutaneous malignant melanoma.
  • [MeSH-major] Melanoma / secondary. Skin Neoplasms / pathology

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  • (PMID = 18496419.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins; 0 / Vimentin
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13. Hillenbrand A, Barth TF, Henne-Bruns D, Formentini A: Anorectal amelanotic melanoma. Colorectal Dis; 2008 Jul;10(6):612-5
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  • [Title] Anorectal amelanotic melanoma.
  • OBJECTIVE: Anorectal melanoma is a rare, highly malignant tumour with a poor 5 year survival of 10%.
  • Most anorectal melanomas have gross and/or histologic pigmentation, however about 30% of anorectal melanomas are amelanotic.
  • METHOD: We report three cases of amelanotic anorectal melanomas and integrate our data with six case reports of amelanotic malignant melanoma from the literature.
  • Further we compare clinicopathological data and clinical outcome with large series of anorectal melanomas (both, amelanotic and pigmentated).
  • A tumour thickness of < 4 mm was correlated with long-term disease-free survival, whereas tumour thickness of 4 mm or more was correlated with systemic recurrence.
  • CONCLUSION: Early diagnosis is key for efficient treatment and improved survival rate for patients with this unusual variant of melanoma.
  • There is no difference in terms of age, time of diagnosis, stage and survival between pigmented and amelanotic anorectal melanoma.
  • [MeSH-major] Anus Neoplasms. Melanoma, Amelanotic. Rectal Neoplasms

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  • (PMID = 17944970.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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14. Ashidi JS, Houghton PJ, Hylands PJ, Efferth T: Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves. J Ethnopharmacol; 2010 Mar 24;128(2):501-12
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  • ETHNOPHARMACOLOGICAL RELEVANCE: There is only scant literature on the anticancer components of medicinal plants from Nigeria, yet traditional healers in the area under study claim to have been managing the disease in their patients with some success using the species studied.
  • Three cancer cell lines (human breast adenocarcinoma cell line MCF-7, human large cell lung carcinoma cell line COR-L23 and human amelanotic melanoma C32) and one normal cell line (normal human keratinocytes SVK-14) were used for the screening of the extracts and the fractions obtained.

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20064598.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Flavanones; 0 / Sitosterols; 0 / pinostrobin; 5LI01C78DD / gamma-sitosterol; 6SMK8R7TGJ / Oleanolic Acid; KM8353IPSO / amyrin
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15. Zamberk-Majlis P, Velázquez-Tarjuelo D, Avilés-Izquierdo JA, Lázaro-Ochaita P: [Dermoscopic characterization of 3 cases of fibroepithelioma of Pinkus]. Actas Dermosifiliogr; 2009 Dec;100(10):899-902
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  • Clinical diagnosis often requires differentiation from benign lesions such as acrochordon, intradermal melanocytic nevus, neurofibroma, seborrheic keratosis, and even malignant lesions such as amelanotic melanoma.

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  • (PMID = 20038369.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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16. Samaila MO, Mbibu HN, Oluwole OP: Human mycetoma. Surg Infect (Larchmt); 2007 Oct;8(5):519-22
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  • However, the disease may present without these characteristic features, thus causing diagnostic difficulty with other chronic granulomatous infections such as tuberculosis or benign skin lesions.
  • The range of clinical misdiagnoses included skin tuberculosis, fibroma, amelanotic melanoma, basal-cell carcinoma, and brain tumor.
  • CONCLUSION: Mycetoma is a disease with sporadic occurrence in our environment.

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  • (PMID = 17999585.001).
  • [ISSN] 1096-2964
  • [Journal-full-title] Surgical infections
  • [ISO-abbreviation] Surg Infect (Larchmt)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Wain EM, Stefanato CM, Barlow RJ: A clinicopathological surprise: amelanotic malignant melanoma. Clin Exp Dermatol; 2008 May;33(3):365-6
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  • [Title] A clinicopathological surprise: amelanotic malignant melanoma.
  • [MeSH-major] Melanocytes / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 18419612.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 6
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18. Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G: How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. J Am Acad Dermatol; 2010 Sep;63(3):377-86; quiz 387-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In contrast to the rarity of amelanotic melanoma, nonmelanoma skin cancer commonly lacks pigmentation.
  • Dermoscopic vascular patterns of several nonmelanocytic nonpigmented skin tumors, such as sebaceous hyperplasia, seborrheic keratosis, clear cell acanthoma, Bowen disease, or nodular cystic basal cell carcinoma are highly specific, allowing a ready diagnosis in most cases.
  • In the second part of this review of dermoscopic vascular structures of nonpigmented skin tumors, the dermoscopic patterns associated with benign and malignant nonmelanocytic skin tumors and recommendations for the management of these tumors will be discussed.
  • [MeSH-minor] Blood Vessels / pathology. Bowen's Disease / blood supply. Bowen's Disease / diagnosis. Bowen's Disease / pathology. Carcinoma, Basal Cell / blood supply. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Education, Medical, Continuing. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / pathology. Male. Melanoma, Amelanotic / blood supply. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology


19. Gualandri L, Betti R, Crosti C: Clinical features of 36 cases of amelanotic melanomas and considerations about the relationship between histologic subtypes and diagnostic delay. J Eur Acad Dermatol Venereol; 2009 Mar;23(3):283-7
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  • [Title] Clinical features of 36 cases of amelanotic melanomas and considerations about the relationship between histologic subtypes and diagnostic delay.
  • BACKGROUND: Amelanotic melanomas (AM) are a difficult diagnostic challenge for clinicians.
  • OBJECTIVE: To consider the clinical presentation of AM, the histologic subtypes involved, the relationship with the diagnostic delay and the possible involvement in overall prognosis.
  • PATIENTS/METHODS: Patients who were observed in our department to be affected by cutaneous melanomas were recorded.
  • AM were divided in three main clinical types: an erythematous macule or patch on sun-exposed skin, a dermal plaque or nodule without a particular epidermal change, an exophytic nodule.
  • Only pure AM were considered.
  • Histological subtypes considered were superficial spreading melanoma, nodular melanoma, and lentigo maligna melanoma.
  • Diagnostic delay considered from when the patients first noticed the lesion on the site where the melanoma was diagnosed and when the physician or the patient first proposed the removal was recorded.
  • RESULTS: Thirty-six cases of AM out of a total of 500 melanomas (7.2%) were collected.
  • Mean Breslow thickness of AM was 1.72 mm compared to 0.61 mm of pigmented cases.
  • Nodular histotype was highly represented in AM (30.5% of cases) with respect to pigmented nodular melanomas (2.9%).
  • The diagnostic delay did not differ between amelanotic and pigmented melanomas, nor between nodular AM and nodular pigmented melanomas.
  • CONCLUSION: The great prevalence of clinical and histological nodular cases, the higher mean Breslow thickness (considered as the most important factor of prognosis) of AM compared with a not significant greater diagnostic delay may point out that a good percentage of AM have an intrinsic faster speed of growth with a worse prognosis irrespectively of the diagnostic performance.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology

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  • (PMID = 19207640.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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20. de Koning HD, Bovenschen HJ: Two adjacent nodules on the leg. Dermatol Online J; 2010;16(6):13
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  • Poroma is a rare benign neoplasm (derived from the intraepidermal part of the eccrine or apocrine duct), which may clinically mimic malignant tumors such as (amelanotic) malignant melanoma and porocarcinoma.
  • Despite a clinical differential diagnosis of melanoma, histopathology showed the typical characteristics of a poroma, a rare but much more favorable tumor.

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  • (PMID = 20579468.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Cichorek M, Kozłowska K, Bryl E: The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. Cancer Biol Ther; 2007 Mar;6(3):346-53
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  • [Title] The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell.
  • Loss of pigment in hamster amelanotic melanoma line is accompanied by a faster growth rate, higher tumorigenicity and shorter animal survival time.
  • Thus, the malignancy of melanoma increases during the alteration of melanotic (Ma) into amelanotic (Ab) line.
  • As changes in the ability to undergo a spontaneous or induced apoptosis, and the role of caspases in this process during melanoma progression are not well defined, they were investigated in this work.
  • Cytochrome c release into cytosol, and the activation of effector caspases, estimated by PARP degradation clearly showed that during the spontaneous death in the cells from both melanoma lines intrinsic way of apoptosis was activated.
  • Confocal and cytometric flow analyses indicate that camptothecin (CPT) induced apoptosis with caspase activation by the intrinsic way only in the amelanotic melanoma cells, even though cells of the Ma line also underwent CPT-induced apoptosis (the content of TUNEL-positive cells increased).
  • Thus, our results suggest that melanoma progression, associated with a decreased ability to undergo spontaneous apoptosis but an increased susceptibility to CPT-induced apoptosis, relates to different levels of caspase activation; they also show that intrinsic way of apoptotis depends on the phenotype of melanoma cells, being more pronounced in the melanotic melanoma cells.
  • On the other hand, melanotic melanoma cells resistance to camptothecin-induced apoptosis suggests that the melanogenic apparatus or melanin itself may have the protective effect on the ability of the melanoma cells to undergo apoptosis.
  • [MeSH-major] Apoptosis. Caspases / metabolism. Melanoma, Amelanotic / enzymology. Melanoma, Experimental / enzymology. Skin Neoplasms / enzymology
  • [MeSH-minor] Animals. Antineoplastic Agents / toxicity. Camptothecin / toxicity. Cell Line, Tumor. Cricetinae. Cytochromes c / metabolism. Disease Progression. Flow Cytometry. Male. Melanins / metabolism. Mesocricetus. Microscopy, Confocal. Poly(ADP-ribose) Polymerases / metabolism

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  • (PMID = 17312383.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Melanins; 9007-43-6 / Cytochromes c; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspases; XT3Z54Z28A / Camptothecin
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22. Avilés-Izquierdo JA, Velázquez-Tarjuelo D, Lecona-Echevarría M, Lázaro-Ochaita P: [Dermoscopic features of eccrine poroma]. Actas Dermosifiliogr; 2009 Mar;100(2):133-6
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  • Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma.

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  • (PMID = 19445878.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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23. Camerin M, Rodgers MA, Kenney ME, Jori G: Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity. Photochem Photobiol Sci; 2005 Mar;4(3):251-3
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  • Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation.
  • [MeSH-minor] Air. Animals. Cell Line, Tumor. Lasers. Melanoma, Experimental / drug therapy. Metalloporphyrins / therapeutic use. Mice. Nitrogen. Time Factors

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  • (PMID = 15738991.001).
  • [ISSN] 1474-905X
  • [Journal-full-title] Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • [ISO-abbreviation] Photochem. Photobiol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Metalloporphyrins; 0 / octabutoxynaphthalocyaninenickel(II); N762921K75 / Nitrogen
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24. Chun JK, Singer E, Kong A, Phelps R, Weltz C: Desmoplastic amelanotic melanoma in an irradiated burn scar. Dermatol Surg; 2006 Jan;32(1):161-4
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  • [Title] Desmoplastic amelanotic melanoma in an irradiated burn scar.
  • [MeSH-major] Burns / complications. Cicatrix / complications. Cicatrix / radiotherapy. Melanoma, Amelanotic / etiology. Skin Neoplasms / etiology

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  • (PMID = 16393619.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. André J, Moulonguet I, Goettmann-Bonvallot S: In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. Arch Dermatol; 2010 Apr;146(4):418-21
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  • [Title] In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases.
  • BACKGROUND: Nail apparatus melanoma is known to be associated with a poor prognosis, mainly because of a delay in diagnosis that is made at an invasive stage.
  • This delay is particularly true in cases involving amelanotic melanoma.
  • To our knowledge, only 1 case of in situ amelanotic melanoma of the nail unit has previously been described.
  • We report 3 cases of in situ amelanotic melanoma with clinical lichenoid features.
  • OBSERVATIONS: We describe 3 cases of in situ amelanotic melanoma of the nail unit.
  • Histologic examination revealed in situ amelanotic melanoma extending from the proximal matrix up to the distal part of the nail bed.
  • CONCLUSIONS: Monodactylic lichenoid nail changes should be added to the more conventional signs of incipient nail melanoma.
  • [MeSH-major] Lichen Planus / diagnosis. Melanoma, Amelanotic / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20404232.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Altamura D, Piccolo D, Lozzi GP, Peris K: Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma. J Am Acad Dermatol; 2005 Sep;53(3):539-41
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  • [Title] Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma.
  • [MeSH-major] Acrospiroma / diagnosis. Dermoscopy. Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16112378.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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27. Yu CH, Chen HH, Liu CM, Jeng YM, Wang JT, Wang YP, Liu BY, Sun A, Chiang CP: HMB-45 may be a more sensitive maker than S-100 or Melan-A for immunohistochemical diagnosis of primary oral and nasal mucosal melanomas. J Oral Pathol Med; 2005 Oct;34(9):540-5
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  • [Title] HMB-45 may be a more sensitive maker than S-100 or Melan-A for immunohistochemical diagnosis of primary oral and nasal mucosal melanomas.
  • BACKGROUND: Primary mucosal melanomas (MMs) of the head and neck are a rare entity.
  • Melanomas with characteristic melanin-pigmented tumor cells are easy to diagnose, but those without melanin-pigmented tumor cells, amelanotic melanomas, are difficult to identify and need immunohistochemistry (IHC) to confirm the final diagnosis.
  • [MeSH-major] Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Melanoma / diagnosis. Mouth Neoplasms / diagnosis. Neoplasm Proteins / analysis. Nose Neoplasms / diagnosis. S100 Proteins / analysis
  • [MeSH-minor] Adult. Aged. Cell Nucleus / pathology. Coloring Agents. Cytoplasm / pathology. Female. Humans. Immunohistochemistry. MART-1 Antigen. Male. Melanocytes / pathology. Melanoma-Specific Antigens. Middle Aged. Mouth Mucosa / pathology. Nasal Mucosa / pathology. Sensitivity and Specificity

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  • (PMID = 16138892.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Coloring Agents; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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28. Pietzner K, Noske A, Cho CH, Kiecker F, Sehouli J: Amelanotic metastasis of melanoma mimicking ovarian cancer: a case report and review of the literature. Anticancer Res; 2008 Jan-Feb;28(1B):563-6
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  • [Title] Amelanotic metastasis of melanoma mimicking ovarian cancer: a case report and review of the literature.
  • Ovarian manifestation of metastatic amelanotic melanoma is exceptionally rare and can lead to the clinical and even histological misdiagnosis of ovarian cancer.
  • She was histologically diagnosed with malignant ovarian tumour and was referred for radical surgery.
  • Postoperative final histological examination and immunohistochemical staining of the tumour revealed an amelanotic epithelioid melanoma.
  • This report discusses the differential diagnosis and clinical management of both metastatic amelanotic malignant melanoma of the ovary and epithelial ovarian cancer.
  • [MeSH-major] Melanoma, Amelanotic / secondary. Ovarian Neoplasms / diagnosis. Skin Neoplasms / secondary

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  • (PMID = 18383903.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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29. Tundis R, Loizzo MR, Bonesi M, Menichini F, Dodaro D, Passalacqua NG, Statti G, Menichini F: In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines. Nat Prod Res; 2009;23(18):1707-18
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  • This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianus Lacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, amelanotic melanoma C32 and human breast adenocarcinoma MCF-7 cell lines.

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  • (PMID = 19921589.001).
  • [ISSN] 1478-6427
  • [Journal-full-title] Natural product research
  • [ISO-abbreviation] Nat. Prod. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hexanes; 0 / Monoterpenes; 0 / Plant Extracts; 0 / Pyrrolizidine Alkaloids; 0 / Sesquiterpenes; 2DDG612ED8 / n-hexane; 54W56MD2WD / humulene; BHW853AU9H / caryophyllene; D81QY6I88E / linalool
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30. Camerin M, Rello-Varona S, Villanueva A, Rodgers MA, Jori G: Metallo-naphthalocyanines as photothermal sensitisers for experimental tumours: in vitro and in vivo studies. Lasers Surg Med; 2009 Nov;41(9):665-73
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  • STUDY DESIGN/MATERIALS AND METHODS: Two octabutoxy-naphthalocyanines centrally coordinated with Pd(II) or Pt(II) ions were prepared by chemical synthesis and tested for their affinity and photothermal sensitisation activity toward a selected tumour cell line, namely B78H1 amelanotic melanoma.
  • The results thus obtained provided a basis for subsequent in vivo studies, aimed at defining the phototherapeutic efficiency of the two metallo-naphthalocyanines: the photosensitisers were i.v. injected into C57BL/6 mice bearing a subcutaneously transplanted amelanotic melanoma and at 24 hours post-injection the tumour area was irradiated by the Ti:sapphire laser using the same protocol as above detailed.
  • RESULTS: Both naphthalocyanines exhibited a high affinity for the amelanotic melanoma cells.
  • Lastly, both metallo-naphthalocyanines, and in particular the Pd(II) derivative, promoted an important response by the amelanotic melanoma, when the neoplastic tissue was irradiated by the pulsed Ti:sapphire laser.
  • [MeSH-major] Laser Therapy. Melanoma, Amelanotic / radiotherapy. Metalloporphyrins / therapeutic use. Organometallic Compounds / therapeutic use. Photochemotherapy / methods. Skin Neoplasms / radiotherapy

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  • [Copyright] Copyright 2009 Wiley-Liss, Inc.
  • (PMID = 19790243.001).
  • [ISSN] 1096-9101
  • [Journal-full-title] Lasers in surgery and medicine
  • [ISO-abbreviation] Lasers Surg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metalloporphyrins; 0 / Organometallic Compounds; 0 / palladium 5,9,14,18,23,27,32,36-octabutoxynaphthalocyanine; 49DFR088MY / Platinum; 5TWQ1V240M / Palladium
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31. Gao N, Li LJ, Li Y, Wang L: Primary amelanotic malignant melanoma of the parotid gland: a case report. J Int Med Res; 2008 Nov-Dec;36(6):1435-9
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  • [Title] Primary amelanotic malignant melanoma of the parotid gland: a case report.
  • Amelanotic malignant melanoma in the oral region is extremely rare and has not previously been reported in the parotid gland.
  • This present case report describes an amelanotic malignant melanoma in the parotid gland, with no other primary lesion detectable.
  • Amelanotic malignant melanoma is a melanoma subtype with little or no pigmentation and, because of this lack of pigmentation and its wide-ranging clinical appearance, it often defies clinical diagnosis.
  • Where it is suspected, positive expression of S-100 protein and human melanoma black 45(HMB45) using immunohistochemical analysis can be considered reliable methods of confirming diagnosis.
  • [MeSH-major] Melanoma, Amelanotic / secondary. Parotid Gland / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, Neoplasm / analysis. Biomarkers, Tumor / analysis. Fatal Outcome. Humans. Lymph Nodes / pathology. Male. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 19094455.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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32. Klopper JP, Sharma V, Bissonnette R, Haugen BR: Combination PPARgamma and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2. PPAR Res; 2010;2010:729876
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  • [Title] Combination PPARgamma and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2.
  • Nuclear hormone receptors, including RXR and PPARgamma, represent novel therapeutic targets in melanoma.
  • We have previously shown that the DRO subline of the amelanotic melanoma A375 responds to rexinoid and thiazolidinedione (TZD) treatment in vitro and in vivo.
  • In summary, we have identified potential downstream mediators of rexinoid and TZD treatment in a poorly differentiated melanoma and found that alterations in S100A2 expression affect RXR and PPARgamma signaling in A375(DRO) cells.

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  • [Cites] J Clin Endocrinol Metab. 2008 Nov;93(11):4331-41 [18713817.001]
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  • (PMID = 19859558.001).
  • [ISSN] 1687-4765
  • [Journal-full-title] PPAR research
  • [ISO-abbreviation] PPAR Res
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA100560
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2763133
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33. Seya T, Tanaka N, Shinji S, Shinji E, Yokoi K, Horiba K, Kanazawa Y, Yamada T, Oaki Y, Tajiri T: Case of rectal malignant melanoma showing immunohistochemical variability in a tumor. J Nippon Med Sch; 2007 Oct;74(5):377-81
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  • [Title] Case of rectal malignant melanoma showing immunohistochemical variability in a tumor.
  • We report on a patient with rectal malignant melanoma.
  • However, the final pathological diagnosis of the surgically resected specimen was malignant amelanotic melanoma of the rectum.
  • However, there were no anticancer drugs tested by CD-DST for malignant melanoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Melanoma / diagnosis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, Neoplasm. Antineoplastic Combined Chemotherapy Protocols / pharmacology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Digestive System Surgical Procedures. Drug Resistance, Neoplasm. Drug Screening Assays, Antitumor / methods. Fatal Outcome. Humans. Immunohistochemistry. Interferon-beta / administration & dosage. Male. Melanoma-Specific Antigens. Neoadjuvant Therapy. Tumor Cells, Cultured

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  • (PMID = 17965534.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 77238-31-4 / Interferon-beta; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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34. Mercadier B, Hu W, Valentin S, Sassolas B: [Amelanotic malignant melanoma: about three cases]. Ann Chir Plast Esthet; 2007 Feb;52(1):68-70
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  • [Title] [Amelanotic malignant melanoma: about three cases].
  • [Transliterated title] Mélanome malin achromique : à propos de trois cas.
  • The amelanotic melanoma is a rare type of malignant melanoma.
  • The purpose of this report is to point out this aspect of melanoma, whose diagnostic delay is frequent.
  • We describe one localisation on the penis, rare in this kind of melanoma and two cases of the extremities, more frequent localization of the amelanotic melanoma.
  • The therapeutic issues and recommendation are similar to the classical pigmented malignant melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 17030390.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. Wang S, Thamboo TP, Nga ME, Zin T, Cheng A, Tan KB: C-kit positive amelanotic melanoma of the oesophagus: a potential diagnostic pitfall. Pathology; 2008 Aug;40(5):527-30
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  • [Title] C-kit positive amelanotic melanoma of the oesophagus: a potential diagnostic pitfall.
  • [MeSH-major] Esophageal Neoplasms / metabolism. Esophageal Neoplasms / pathology. Melanoma, Amelanotic / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis

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  • (PMID = 18604743.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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36. Kusick S, Bertram H, Oberleithner H, Ludwig T: Nanoscale imaging and quantification of local proteolytic activity. J Cell Physiol; 2005 Sep;204(3):767-74
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  • Malignant cells secrete most proteases as inactive proenzymes that undergo proteolytic cleavage for activation, and proteolytic activity is elevated in close proximity to these cells.
  • Amelanotic melanoma cells (A7-clone) were seeded on fluorescent gelatin or collagen-IV coatings.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15744770.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins; EC 3.4.- / Peptide Hydrolases
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37. De Simone P, Gelin M, El Nakadi I: Amelanotic malignant melanoma of the esophagus. Report of a case. Minerva Chir; 2006 Feb;61(1):45-9
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  • [Title] Amelanotic malignant melanoma of the esophagus. Report of a case.
  • Primary malignant melanomas of the esophagus are rare neoplasms with aggressive behavior and tendency to lymphatic and hematogenous spread.
  • We report on a patient affected with a primary amelanotic melanoma of the esophagus synchronous to a squamous cell carcinoma of the epiglottis and treated by subtotal esophagectomy.
  • Review of patient's medical history and exploration of skin and mucous membranes failed to reveal malignant lesions and definitive diagnosis was primary amelanotic malignant melanoma of the esophagus.
  • The patient died 16 months after surgery of disseminated disease.
  • In conclusion the present case confirms that primary malignant melanomas of the esophagus have a dismal outcome even in cases of early-stage lesions amenable to surgical resection.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Epiglottis. Esophageal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Melanoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16568022.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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38. Brozyna AA, VanMiddlesworth L, Slominski AT: Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy. Int J Cancer; 2008 Sep 15;123(6):1448-56
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  • [Title] Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy.
  • Melanin pigment displays strong photo- and radioprotective properties, suggesting that inhibition melanogenesis could increase sensitivity of melanoma to ionizing radiation.
  • We tested this concept in human melanoma cells cultured in either Ham's F10 medium to maintain amelanotic phenotype or DMEM to induce/stimulate melanin production, respectively; N-phenylthiourea (PTU) and D-penicillamine were used as an inhibitor of melanogenesis.
  • Amelanotic cells or cells with various melanin content were exposed to gamma radiation and tested for viability and colony forming capability.
  • Gamma radiation at doses of 2-15 Gy inhibited cell viability and colony forming efficiency in dose- and time-dependent manner, but pigmented melanoma cells were significantly more resistant to gamma radiation than nonpigmented cells (p < 0.05-0.001).
  • Both PTU and D-penicillamine inhibited strongly tyrosinase activity and melanin production in melanoma cells (p < 0.05-0.001).
  • Furthermore, inhibition of melanogenesis by PTU or D-penicillamine resulted in enhancement of melanoma cells sensitivity to killing by gamma rays.
  • In conclusion, the results of these cell culture experiments give support to a clinical trial of pharmacologically induced decrease in melanin synthesis to enhance the efficacy of radiotherapy in advanced melanomas.
  • [MeSH-major] Melanins / metabolism. Melanoma / radiotherapy. Radiation Tolerance / physiology
  • [MeSH-minor] Cell Line, Tumor. Cell Survival / radiation effects. Humans. Melanoma, Amelanotic / radiotherapy. Penicillamine / pharmacology. Phenylthiourea / pharmacology. Radiation, Ionizing. Radiation-Sensitizing Agents / pharmacology

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • (PMID = 18567001.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins; 0 / Radiation-Sensitizing Agents; 6F82C6Q54C / Phenylthiourea; GNN1DV99GX / Penicillamine
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39. Jain V, Dabir S, Shome D, Dadu T, Natarajan S: Aspergillus iris granuloma: a case report with review of literature. Surv Ophthalmol; 2009 Mar-Apr;54(2):286-91
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  • Differential diagnoses of a fungal granuloma, a medulloepithelioma, and an amelanotic melanoma were considered.
  • Definitive differentiation of this rare entity from a foreign body, amelanotic melanoma, and other inflammatory conditions such as sarcoidosis and tuberculosis, may be possible only on microbiological and histo-pathological evaluation.

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  • (PMID = 19298905.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Aza Compounds; 0 / DNA, Fungal; 0 / Fluoroquinolones; 0 / Quinolines; 7C0697DR9I / Atropine; 8O0C852CPO / Natamycin; U188XYD42P / moxifloxacin
  • [Number-of-references] 18
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40. Conforti F, Ioele G, Statti GA, Marrelli M, Ragno G, Menichini F: Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem Toxicol; 2008 Oct;46(10):3325-32
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  • Sixteen edible plants from Southern Italy were evaluated for their in vitro antiproliferative properties, using the sulforodamine B (SRB) assay, on four human cancer cell lines: breast cancer MCF-7, prostate cancer LNCaP, amelanotic melanoma C32 and renal adenocarcinoma ACHN.
  • Mentha aquatica showed a selective antiproliferative activity on breast cancer while significant activity was exerted by Cichorium intybus on melanoma.

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  • (PMID = 18768152.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Plant Extracts
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41. Blum A: [Therapy of amelanotic melanoma]. Dtsch Med Wochenschr; 2005 May 20;130(20):1277
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapy of amelanotic melanoma].
  • [MeSH-major] Melanoma, Amelanotic / therapy. Skin Neoplasms / therapy

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  • (PMID = 15889328.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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42. Pirenne Y, Bouckaert W, Vangertruyden G: Rectal melanoma--a rare tumour. Acta Chir Belg; 2008 Nov-Dec;108(6):756-8
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  • [Title] Rectal melanoma--a rare tumour.
  • Malignant rectal melanoma is a rare tumour.
  • Biopsies proved it to be an amelanotic malignant melanoma, as protein S100, melanoma antigen HMB45 and Melan-A expression were found.
  • Histology confirmed an amelanotic malignant melanoma.
  • With this case we want to illustrate that malignant rectal melanoma can be difficult to diagnose, as patients have non-specific symptoms, and histology may be misleading.
  • One should always check for protein S-100, melanoma antigen HMN-45 and Melan-A expression, as they are strongly suggestive of melanoma.
  • Rectal melanoma has a poor outcome with a 5-year survival rate of between 10-20%.
  • The extent of the disease correlates with the overall survival.
  • [MeSH-major] Melanoma, Amelanotic / surgery. Rectal Neoplasms / surgery

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  • (PMID = 19241934.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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43. Kurotaki T, Tomonari Y, Kanno T, Wako Y, Tsuchitani M: A novel immunohistochemical marker of normal and neoplastic melanocytes in formalin-fixed, paraffin-embedded tissues of albino rats. Vet Pathol; 2008 May;45(3):383-7
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  • The samples consisted of 11 (1.57%) amelanotic melanomas in 700 rats (2 studies), 23 non-melanocytic tumors, and a wide variety of normal tissues.
  • In amelanotic melanoma, the tumor cells consisted of spindle cells with eosinophilic cytoplasm without melanin granules.
  • PNL2 consistently stained cytoplasm in all amelanotic melanoma cells.
  • [MeSH-major] Melanocytes / cytology. Melanocytes / pathology. Melanoma / pathology

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  • (PMID = 18487499.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Trzcinski R, Kujawski R, Mik M, Sygut A, Dziki L, Dziki A: Malignant melanoma of the anorectum--a rare entity. Langenbecks Arch Surg; 2010 Aug;395(6):757-60
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  • [Title] Malignant melanoma of the anorectum--a rare entity.
  • OBJECTIVE: Primary anorectal melanoma is a rare entity with a poor prognosis accounting for approximately 0.1-4.6% of anal tumours and 0.5-1.6% of all melanomas.
  • Almost 60% of patients have already disseminated disease at initial diagnosis.
  • METHOD: We report four cases of anorectal melanoma treated at our department from November 2006 to September 2008, as well as a review of the literature.
  • Three of our four patients had amelanotic melanomas.
  • Three patients died on account of dissemination of melanoma, one patient is still alive.
  • CONCLUSION: Anal melanoma remains a deadly problem.
  • Clear guidelines for the therapy of anorectal melanoma have not been established.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / therapy. Melanoma / diagnosis. Melanoma / therapy. Rectal Neoplasms / diagnosis. Rectal Neoplasms / therapy

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  • (PMID = 20066546.001).
  • [ISSN] 1435-2451
  • [Journal-full-title] Langenbeck's archives of surgery
  • [ISO-abbreviation] Langenbecks Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
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45. Ishii H, Joshita T, Matsuyama N, Uchida T, Ishikawa A, Ebihara Y: Immunohistochemical and ultrastructural investigation on cutaneous neuroendocrine carcinoma: report of a case and review of the literature. Med Mol Morphol; 2006 Sep;39(3):164-8
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  • We report a tumor in an 80-year-old man that was difficult to distinguish from other tumors, i.e., small cell carcinoma of the lung, PNET/Ewing tumor, malignant lymphoma, or malignant melanoma (amelanotic), and which was finally identified as cutaneous neuroendocrine carcinoma using immunohistochemical and ultrastructural methods.
  • Immunohistochemistry tests gave negative results for LCA, UCHL-1, CD3, and CD20, thereby excluding malignant lymphoma, and the negative results for S-100 protein and HMB-45 ruled out malignant melanoma.

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  • (PMID = 16998628.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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46. Khaled A, Hammami H, Fazaa B, Kourda N, Kamoun MR, Ben Jilany S, Zoghlami A: Primary amelanotic anorectal melanoma: an uncommon neoplasia with poor prognosis. Pathologica; 2009 Jun;101(3):126-9
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  • [Title] Primary amelanotic anorectal melanoma: an uncommon neoplasia with poor prognosis.
  • BACKGROUND: Anorectal melanoma is a rare and aggressive mucosal cancer.
  • There is usually a delay in diagnosis because about 30% of these cancers are amelanotic and are often mistaken for benign conditions.
  • Herein, we report a case of amelanotic anorectal malignant melanoma with an unusual metastatic deposit in the vulva and also review the literature.
  • Clinical examination showed a pedunculated and ulcerated amelanotic tumour associated with three other nodules, 1 cm in diameter, localized in the vulval mucosa.
  • Histological examination and immunohistochemical staining of all tumours demonstrated malignant melanoma.
  • DISCUSSION: Nine cases of amelanotic malignant melanoma have been reported in the literature.
  • Anorectal melanoma is most common in the rectum, followed by the anal canal.
  • Our case is the tenth case of amelanotic anorectal melanoma and probably corresponds to multiple synchronous primary melanomas of the anorectal region and the vulva, with the possibility that one of the lesions is a primary melanoma and the others are satellite lesions.
  • [MeSH-major] Anus Neoplasms / pathology. Melanoma, Amelanotic / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19886548.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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47. Schöttler L, Körber A, Denisjuk N, Freise J, Dissemond J: [Malignant melanoma masquerading as a neurotrophic ulcer]. Med Klin (Munich); 2009 Sep 15;104(9):723-6
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  • [Title] [Malignant melanoma masquerading as a neurotrophic ulcer].
  • [Transliterated title] Malignes Melanom imitiert ein neurotrophes Ulkus.
  • After the initial examination in the outpatient wound healing clinic, a malignant melanoma already showing invasive growth with a penetration depth of 4.6 mm was detected in a biopsy.
  • CONCLUSION: Malignant melanoma is a primary cutaneous malignant tumor.
  • Ulcerated and amelanotic melanomas still present a considerable clinical challenge due to the likelihood of being mistaken for benign diseases and the occurrence of filiae when diagnosis is made too late.
  • This case report demonstrates the importance of differential diagnostic consideration of neoplasias, for example malignant melanoma, in cases of unclear, therapy-refractory wounds and discusses the relevant aspects in avoiding an unnecessary prolongation of diagnostics.
  • [MeSH-major] Diabetic Foot / diagnosis. Diabetic Nephropathies / diagnosis. Heel. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19779677.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 9008-11-1 / Interferons
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48. Ladoyanni E, Abdullah A, Sterne GD, Zaki I: Amelanotic melanoma--"to be or not to be". Acta Derm Venereol; 2006;86(2):189-90
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  • [Title] Amelanotic melanoma--"to be or not to be".
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16648938.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
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49. Dickinson RM, Young KM: Cutaneous mass aspirate from a Golden Retriever: "glandular guile". Vet Clin Pathol; 2005 Dec;34(4):421-4
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  • On cytologic evaluation of a fine-needle aspirate of the mass, the interpretation was a malignant tumor with predominantly mesenchymal features.
  • Differentials included liposarcoma, atypical amelanotic melanoma, anaplastic sarcoma, and anaplastic carcinoma.

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  • (PMID = 16270273.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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50. Lee SH, Hong JS, Choi JH, Chung WS: Choroidal schwannoma. Acta Ophthalmol Scand; 2005 Dec;83(6):754-6
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  • CONCLUSIONS: We enucleated the eyeball with a clinical diagnosis of choroidal amelanotic melanoma, but the tumor was finally diagnosed as schwannoma.

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  • (PMID = 16396657.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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51. Conforti F, Menichini F, Rigano D, Senatore F: Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes. Z Naturforsch C; 2009 Jul-Aug;64(7-8):490-4
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  • The in vitro cytotoxic activity assay against two human cancer cell lines, large lung carcinoma (CORL-23) and amelanotic melanoma (C32), showed that the most antiproliferative extract was the MeOH extract from flowers with a percentage of inhibition of 50.9 at 100 microg/ml against amelanotic melanoma cells.
  • The most antiproliferative compounds against amelanotic melanoma cells were kaempferol-3-O-beta-D-glucopyranoside and irisolidone with a percentage of inhibition of 100 and 96.6, respectively, and against large lung carcinoma cells with a percentage of inhibition of 82.1 and 84.6, respectively.
  • Significant activity on the amelanotic melanoma cell line was also showed by irigenin-7-O-beta-D-glucopyranoside, with a percentage of inhibition of 89.3.
  • The compounds isovitexin and isoorientin-6-O''-beta-D-glucopyranoside showed a selective activity against amelanotic melanoma cells with a percentage of inhibition of 83.2 and 79.8, respectively.
  • [MeSH-minor] Carcinoma, Large Cell / pathology. Cell Line, Tumor. Humans. Lung Neoplasms / pathology. Melanoma, Amelanotic / pathology. Plant Extracts / chemistry. Polyphenols

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  • (PMID = 19791498.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Flavonoids; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols
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52. Donaldson MJ, Lim L, Harper CA, Mackenzie J, G Campbell W: Primary treatment of choroidal amelanotic melanoma with photodynamic therapy. Clin Exp Ophthalmol; 2005 Oct;33(5):548-9
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  • [Title] Primary treatment of choroidal amelanotic melanoma with photodynamic therapy.
  • The management of choroidal melanoma involves a delicate balance between preserving vision and preventing metastasis.
  • Transpupillary thermotherapy avoids these side-effects; however, it can also result in visual loss and its effectiveness is limited in amelanotic lesions.
  • Photodynamic therapy with verteporfin has shown promise in animal studies of choroidal melanoma, and has recently been used in the management of lesions that have failed to respond to conventional therapy.
  • The authors report a case of primary treatment of a small choroidal amelanotic melanoma with photodynamic therapy using verteporfin.
  • [MeSH-major] Choroid Neoplasms / drug therapy. Melanoma, Amelanotic / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use. Porphyrins / therapeutic use

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  • [CommentIn] Clin Exp Ophthalmol. 2006 Sep-Oct;34(7):721; author reply 721-2 [16970777.001]
  • (PMID = 16181294.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 129497-78-5 / verteporfin
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53. Morita N, Hiratsuka J, Kondoh H, Uno M, Asano T, Niki Y, Sakurai Y, Ono K, Harada T, Imajo Y: Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene. Cancer Res; 2006 Apr 1;66(7):3747-53
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  • [Title] Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
  • In melanoma, (10)B-para-boronophenylalanine (BPA) accumulation is proportional to melanin-producing activity.
  • This study was done to confirm enhancement of the tumor-suppressive effect of BNCT on amelanotic melanoma by intratumoral injection of the tyrosinase gene.
  • D178 or FF amelanotic melanomas were implanted s.c. in Syrian hamsters.
  • In vivo transfection with the tyrosinase gene increased BPA accumulation in the tumors, the BNCT tumor-suppressive effect on amelanotic melanoma being significantly enhanced.
  • These findings suggest a potential new clinical strategy for the treatment of amelanotic melanoma with BNCT.
  • [MeSH-major] Boron Neutron Capture Therapy / methods. Genetic Therapy / methods. Melanoma, Amelanotic / enzymology. Melanoma, Amelanotic / radiotherapy. Monophenol Monooxygenase / genetics. Skin Neoplasms / enzymology. Skin Neoplasms / radiotherapy

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  • (PMID = 16585201.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Boron Compounds; 0 / Radiation-Sensitizing Agents; 47E5O17Y3R / Phenylalanine; EC 1.14.18.1 / Monophenol Monooxygenase; UID84303EL / 4-boronophenylalanine
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54. Harwood M, Telang GH, Robinson-Bostom L, Jellinek N: Melanoma and squamous cell carcinoma on different nails of the same hand. J Am Acad Dermatol; 2008 Feb;58(2):323-6
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  • [Title] Melanoma and squamous cell carcinoma on different nails of the same hand.
  • A case is presented of a patient with two separate and concurrent malignant neoplasms of the nail unit, on different nails on the same hand, each featuring an unusual clinical presentation: amelanotic melanoma presenting as longitudinal erythronychia and squamous cell carcinoma in situ presenting as longitudinal melanonychia.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Melanoma, Amelanotic / pathology. Nail Diseases / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 18222331.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Yoon TY, Kim HJ, Kim JW, Kim MK, Lee JY: Bowen's disease concealed by purpura. J Dermatol; 2007 Jan;34(1):65-7
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  • [Title] Bowen's disease concealed by purpura.
  • Bowen's disease (BD) is a squamous cell carcinoma in situ characterized by a well-demarcated scaly erythematous thin plaque with an irregular outline.
  • Clinically, BD is frequently misdiagnosed as superficial basal cell carcinoma, patches of dermatitis, psoriasis, lichen planus, actinic keratosis, benign lichenoid keratosis, irritated seborrheic keratosis, viral warts, amelanotic melanoma or melanoma.
  • [MeSH-major] Bowen's Disease / complications. Purpura / complications. Scalp. Skin Neoplasms / complications

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  • (PMID = 17204105.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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56. Ren G, Miao Z, Liu H, Jiang L, Limpa-Amara N, Mahmood A, Gambhir SS, Cheng Z: Melanin-targeted preclinical PET imaging of melanoma metastasis. J Nucl Med; 2009 Oct;50(10):1692-9
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  • [Title] Melanin-targeted preclinical PET imaging of melanoma metastasis.
  • Dialkylamino-alkyl-benzamides possess an affinity for melanin, suggesting that labeling of such benzamides with (18)F could potentially produce melanin-targeted PET probes able to identify melanotic melanoma metastases in vivo with high sensitivity and specificity.
  • In vivo distribution and small-animal PET studies were conducted on mice bearing B16F10 melanoma, A375M amelanotic melanoma, and U87MG tumors, and comparative studies were performed with (18)F-FDG PET in the melanoma models.
  • In vivo, (18)F-FBZA displayed significant tumor uptake; at 2 h, 5.94 +/- 1.83 percentage injected dose (%ID) per gram was observed in B16F10 tumors and only 0.75 +/- 0.09 %ID/g and 0.56 +/- 0.13 %ID/g was observed in amelanotic A375M and U87MG tumors, respectively.
  • CONCLUSION: (18)F-FBZA specifically targets primary and metastatic melanotic melanoma lesions with high tumor uptake and may have translational potential.

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  • (PMID = 19759116.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA114747; United States / NCI NIH HHS / CA / R24 CA93862
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzamides; 0 / Fluorine Radioisotopes; 0 / Melanins; 0 / Receptors, sigma
  • [Other-IDs] NLM/ NIHMS636087; NLM/ PMC4215196
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57. Godbole D, Mojamdar M, Pal JK: Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis. Cell Biol Int; 2006 Nov;30(11):895-902
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  • [Title] Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
  • Proteasomes have been shown to be involved in the regulation of melanin biosynthesis in melanoma cells.
  • Here we report on the correlation between proteasome subunits and Tyrosinase (Tyr) activity in different cell phenotypes, and thereby regulation of melanin biosynthesis in B16F10 mouse melanoma cells.
  • Our results indicated that the quantity of proteasome subunit p27 is higher and that of the enzyme Tyr and its activity are lower in amelanotic melanoma cells, while the reverse is true in melanotic melanoma cells.
  • Proteasome subunit p27, compared to another subunit p31, shows increased co-localization with Tyr and Tyrosinase related protein 1 (Trp1) in amelanotic cells to a greater extent than that in melanotic cells.
  • On exposure to cycloheximide, increased Tyr degradation was seen in amelanotic cells, as indicated by increased co-localization of p27 and Tyr.
  • Further, exposure of amelanotic melanoma cells with proteasome-specific inhibitor MG132 resulted in an increased Tyr activity, increased levels of Tyr and Trp1, leading to increased melanin synthesis.
  • These results therefore suggest that proteasomes, particularly p27 subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells.
  • [MeSH-major] Melanins / biosynthesis. Melanoma, Amelanotic / enzymology. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / metabolism. Proteasome Endopeptidase Complex / metabolism. Protein Subunits / metabolism

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  • (PMID = 16879986.001).
  • [ISSN] 1065-6995
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leupeptins; 0 / Melanins; 0 / Proteasome Inhibitors; 0 / Protein Subunits; 133407-82-6 / benzyloxycarbonylleucyl-leucyl-leucine aldehyde; 98600C0908 / Cycloheximide; EC 1.- / Oxidoreductases; EC 1.14.18.- / tyrosinase-related protein-1; EC 1.14.18.1 / Monophenol Monooxygenase; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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58. Valdes A, Kulekowskis AM, Curtis L: Case report: amelanotic melanoma located on the lower extremity. Am Fam Physician; 2007 Dec 1;76(11):1614, 1618
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  • [Title] Case report: amelanotic melanoma located on the lower extremity.
  • [MeSH-major] Foot. Melanoma, Amelanotic. Skin Neoplasms

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  • [CommentOn] Am Fam Physician. 2005 Jul 15;72(2):269-76 [16050450.001]
  • (PMID = 18092703.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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59. Traynor NJ, McKenzie RC, Beckett GJ, Gibbs NK: Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation. Photodermatol Photoimmunol Photomed; 2006 Dec;22(6):297-303
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  • METHODS: We examined whether selenomethionine could protect human skin cells from UV radiation-induced p53 transactivation, using a pRGCDeltafos-lacZ p53-dependent reporter construct stably transfected in an amelanotic melanoma cell line (Arn-8) which expresses wild-type p53.

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  • (PMID = 17100737.001).
  • [ISSN] 0905-4383
  • [Journal-full-title] Photodermatology, photoimmunology & photomedicine
  • [ISO-abbreviation] Photodermatol Photoimmunol Photomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Radiation-Protective Agents; 0 / Tumor Suppressor Protein p53; 964MRK2PEL / Selenomethionine
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60. Wachulska M, Kozłowska K, Cichorek M: The DNA ploidy and proliferative activity of transplantable melanoma cells in regard to their secretory function. Neoplasma; 2005;52(4):280-6
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  • [Title] The DNA ploidy and proliferative activity of transplantable melanoma cells in regard to their secretory function.
  • The study concerns DNA ploidy and proliferative activity of the cells of two hamster transplantable melanoma lines - differing in many biological features - in the light of possible changes in their secretory activity.
  • Our results indicate that melanotic melanoma cells (Ma) have a near-tetraploid DNAcontent and about 18% of proliferating cells, while amelanotic melanoma cells (Ab) - have a near-triploid DNA content and almost twice as many proliferating cells.
  • The Ab cells, in comparison with Ma cells, secreted in vitro less total protein and most of the cytokines examined except OSM, but a spontaneous alteration of transplantable melanoma was accompanied by an increase of the quantity and dynamics of NO secretion.
  • So, the cells of two melanoma lines have their own characteristic pattern of secretory function.
  • But, the aneuploidy which accompanied the changes in cell differentiation of the studied melanoma lines, although seemed to reflect their changes in the proliferative activity, nevertheless did not reflect, in a direct way, differences in the secretion of the substances studied.
  • [MeSH-major] DNA, Neoplasm / analysis. Melanoma / pathology. Melanoma / secretion. Ploidies. Skin Neoplasms / pathology. Skin Neoplasms / secretion


61. Rütten A: [Malignant melanoma in children and adolescents]. Pathologe; 2007 Nov;28(6):437-44
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  • [Title] [Malignant melanoma in children and adolescents].
  • According to data from the literature and to new data from the German central registry for malignant melanomas from the German Society of Dermatology, a summary is given about the occurrence of malignant melanoma in children and adolescents up to 18 years of age.
  • During the first 10 years of life the occurrence of a melanoma is extremely rare, but slowly increases after the first decade.
  • Several studies have shown that young people often have amelanotic tumors resembling pyogenic granuloma.
  • This correlates with a histopathological high number of nodular melanomas in this age group.
  • A reason might be a delay in the clinical diagnosis of malignant melanoma in children and young adults.
  • Clinical and histopathological examples of melanoma in young people are demonstrated.
  • Pitfalls in differential diagnosis and simulators of malignant melanoma are described and illustrated by examples of a medium sized congenital nevus with extensive intraepithelial spread of single melanocytes resembling a superficial spreading melanoma and by a compound nevus in association with a lichen sclerosus et atrophicus.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17874108.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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62. Patel GA, Ragi G, Krysicki J, Schwartz RA: Subungual melanoma: a deceptive disorder. Acta Dermatovenerol Croat; 2008;16(4):236-42
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  • [Title] Subungual melanoma: a deceptive disorder.
  • Subungual melanoma is an uncommon form of acral melanoma that arises within the nail bed.
  • The incidence for acral melanomas is similar worldwide, but the proportion is higher in dark-skinned individuals.
  • The subungual form represents about 2% of cutaneous non-sun induced melanomas in the western world, and up to 75% in Africans, 10% in Japanese, and 25% in the Chinese of Hong Kong.
  • Up to 33% of subungual melanomas are amelanotic.
  • Non-specific features and symptoms along with a high incidence of amelanosis often lead to delayed diagnosis, disease progression, and a poor prognosis with challenging treatment options.
  • [MeSH-major] Melanoma / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19111151.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 40
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63. Elizalde J, Ubia S, Barraquer RI: Adenoma of the nonpigmented ciliary epithelium. Eur J Ophthalmol; 2006 Jul-Aug;16(4):630-3
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  • Adenoma of the non pigmented ciliary epithelium may mimic an amelanotic melanoma.

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  • (PMID = 16952109.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. McGregor DH, Cherian R, Romanas MM, Ulusarac O, Mathur SC, Feldman MM: Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma. Ann Clin Lab Sci; 2008;38(2):157-62
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  • [Title] Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma.
  • We report 2 cases of collision tumors involving amelanotic malignant melanoma of the back.
  • Subsequent excision showed that the lesion was largely composed of amelanotic melanoma underlying a relatively small and thin basal cell carcinoma, and this probably would have been demonstrated in a punch (rather than shave) biopsy.
  • The other patient is a 71-yr-old male with a 1 cm exophytic lesion on the back, which was determined microscopically to be melanoma, and a 0.6 cm papule on the back.
  • This lesion was composed of 2 distinct contiguous neoplastic infiltrates, the predominant component being an atypical fibroxanthoma and the smaller component an amelanotic melanoma (primary vs metastatic), with diagnostic confirmation requiring multiple immunohistochemical stains.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma, Amelanotic / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 18469362.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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65. Gosselink CP, Sindone JL, Meadows BJ, Mohammadi A, Rosa M: Amelanotic subungual melanoma: a case report. J Foot Ankle Surg; 2009 Mar-Apr;48(2):220-4
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  • [Title] Amelanotic subungual melanoma: a case report.
  • Subungual melanoma is a disorder that accounts for 2% to 3% of all melanoma cases.
  • We report the case of a 31-year-old male patient presenting with a rapidly growing mass localized to the hallux, which eventually resulted in the diagnosis of an ulcerated amelanotic subungual melanoma.
  • Because of their lack of pigmentation, amelanotic melanoma is frequently misdiagnosed for other more common forms of cutaneous compromise, and a delay in proper treatment because of failure to make the diagnosis can greatly decrease the likelihood of a favorable outcome.
  • [MeSH-major] Hallux. Melanoma, Amelanotic / pathology. Nail Diseases / pathology. Skin Neoplasms / pathology

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  • (PMID = 19232976.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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66. Cemil B, Emmez H, Oztanir N, Tokgoz N, Dogulu F: A cystic amelanotic melanoma metastasis to the brain: case report. Neurocirugia (Astur); 2008 Aug;19(4):365-7
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  • [Title] A cystic amelanotic melanoma metastasis to the brain: case report.
  • As far as we know, cyst formation in intracranial melanoma is rare, and only 15 cases of intracranial amelanotic melanoma have been reported until now.
  • The imaging features of metastatic melanomas are distinctive due to the presence of melanin and the propensity for hemorrhage.
  • [MeSH-major] Brain Neoplasms / secondary. Cysts / pathology. Melanoma, Amelanotic / secondary

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  • (PMID = 18726049.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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67. Matusiak L, Bieniek A, Wozniak Z, Szepietowski JC: Amelanotic malignant melanoma in an acral location. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Jun;17(2):72-4
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  • [Title] Amelanotic malignant melanoma in an acral location.
  • The biopsy, stained with H and E, revealed an anaplastic malignant tumor.
  • Additional immunochemical staining with Melan A allowed us to make the final diagnosis: amelanotic malignant melanoma (MM).
  • The melanoma was removed by amputation of digits IV and V, with partial removal of the metatarsal bones (Clark degree 5, Breslow thickness 9 mm).
  • [MeSH-major] Foot Dermatoses / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 18709293.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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68. de Giorgi V, Sestini S, Massi D, Maio V, Giannotti B: Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study. J Am Acad Dermatol; 2006 Feb;54(2):341-4
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  • [Title] Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study.
  • Completely amelanotic melanomas are rare and therefore often misclassified, with tragic consequences for patients.
  • We present a case of "true" amelanotic melanoma on the forehead of an 89-year-old man, which clinically mimicked squamous cell carcinoma.
  • The dermoscopic diagnostic algorithms routinely used for pigmented lesions are not helpful in diagnosing amelanotic melanoma because they are based on specific parameters not normally seen in amelanotic lesions.
  • In the light of our experience, pattern analysis is the most reliable method for diagnosing these particular lesions correctly because it allows in-depth morphologic analysis of the few parameters found.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology

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  • [CommentIn] J Am Acad Dermatol. 2006 Oct;55(4):728 [17010767.001]
  • (PMID = 16443072.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Auer-Grumbach M: Hereditary sensory neuropathy type I. Orphanet J Rare Dis; 2008;3:7
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  • Hereditary sensory neuropathy type I (HSN I) is a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset.
  • Disease onset varies between the 2nd and 5th decade of life.
  • Differential diagnosis includes the other hereditary sensory and autonomic neuropathies (HSAN), especially HSAN II, as well as diabetic foot syndrome, alcoholic neuropathy, neuropathies caused by other neurotoxins/drugs, immune mediated neuropathy, amyloidosis, spinal cord diseases, tabes dorsalis, lepra neuropathy, or decaying skin tumours like amelanotic melanoma.
  • The disorder is slowly progressive and does not influence life expectancy but is often severely disabling after a long duration of the disease.

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  • (PMID = 18348718.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 35
  • [Other-IDs] NLM/ PMC2311280
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70. Bapst JP, Froidevaux S, Calame M, Tanner H, Eberle AN: Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity. J Recept Signal Transduct Res; 2007;27(5-6):383-409
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  • Dimeric analogs of alpha-melanocyte-stimulating hormone (alpha-MSH) labeled with radiometals are potential candidates for diagnosis and therapy of melanoma by receptor-mediated tumor targeting.
  • Both melanotic and amelanotic melanomas (over-)express the melanocortin-1 receptor (MC1-R), the target for alpha-MSH.
  • In the past, dimerized MSH analogs have been shown to display increased receptor affinity compared to monomeric MSH, offering the possibility of improving the ratio between specific uptake of radiolabeled alpha-MSH by melanoma and nonspecific uptake by the kidneys.
  • In vitro, all three peptides were more potent ligands of the mouse B16-F1 melanoma cell melanocortin-1 receptor (MC1-R) than DOTA-NAPamide, which served as standard.
  • Using human HBL melanoma cells, the binding activity of diHexa(NC-NC)-Gly-Lys(DOTA)-amide was sixfold higher than that of DOTA-NAPamide.
  • It appears that despite the higher affinity to the MC1-R of the peptide dimers and their excellent internalization in vitro, the uptake by melanoma tumors in vivo was lower, possibly because of reduced tissue penetration.
  • [MeSH-major] Heterocyclic Compounds, 1-Ring / metabolism. Melanoma, Experimental / metabolism. Oligopeptides / metabolism. alpha-MSH / analogs & derivatives

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  • (PMID = 18097939.001).
  • [ISSN] 1079-9893
  • [Journal-full-title] Journal of receptor and signal transduction research
  • [ISO-abbreviation] J. Recept. Signal Transduct. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chelating Agents; 0 / Heterocyclic Compounds, 1-Ring; 0 / Indium Radioisotopes; 0 / Oligopeptides; 581-05-5 / alpha-MSH; 60239-18-1 / 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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71. Martínez-Hernández-Magro P, Villanueva-Sáenz E, Chávez-Colunga LB: [Anal malignant melanoma. Case report and literature review]. Rev Gastroenterol Mex; 2009;74(1):39-44
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  • [Title] [Anal malignant melanoma. Case report and literature review].
  • [Transliterated title] Melanoma maligno anal. Reporte de casos y revisión de la literatura.
  • OBJECTIVE: To present two cases of anorectal malignant melanoma as due to its non specific presentation and rarity they are often misdiagnosed like hemorrhoids.
  • BACKGROUND: Anal melanomas are rare tumors that constitute less than 1% of the malignant colorectal tumors and represent both a diagnostic and therapeutic challenge to physicians.
  • They are generally pigmented but could be amelanotic in 29% of the cases and they are associated with poor prognosis, regardless of the surgical procedure used.
  • Melanomas are often misdiagnosed by a lot of anorectal conditions and diagnosis must be suspected in patients with an anal mass.
  • CASE REPORT: We present two anorectal cases of malignant melanoma treated by wide local excision, the principal complain in both patients was the presence of an anal mass and bleeding.
  • CONCLUSIONS: Anal melanoma is a rare entity with a poor prognosis.
  • [MeSH-major] Anus Neoplasms / pathology. Melanoma / pathology

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  • (PMID = 19666318.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
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72. Stringa O, Valdez R, Beguerie JR, Abbruzzese M, Lioni M, Nadales A, Iudica F, Venditti J, San Roman A: Primary amelanotic melanoma of the esophagus. Int J Dermatol; 2006 Oct;45(10):1207-10
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  • [Title] Primary amelanotic melanoma of the esophagus.
  • Primary melanoma of the esophagus (PME) is an uncommon malignancy with less than 250 cases reported in the literature.
  • Amelanotic PME is exceedingly rare and accounts for 10-25% of melanomas of the esophagus.
  • No skin or eye melanoma lesions were found.
  • Peritumoral lymph nodes revealed malignant invasion.
  • A diagnosis of primary amelanotic melanoma of the esophagus was made.
  • [MeSH-major] Esophageal Neoplasms / pathology. Melanoma, Amelanotic / pathology


73. Lovato L, Salerni G, Puig S, Carrera C, Palou J, Malvehy J: Adult xanthogranuloma mimicking basal cell carcinoma: dermoscopy, reflectance confocal microscopy and pathological correlation. Dermatology; 2010;220(1):66-70
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  • Juvenile xanthogranuloma in adulthood is an infrequent non-Langerhans cell histiocytosis, which may simulate malignant tumors such as basal cell carcinoma (BCC) or amelanotic melanoma.

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] J Cutan Pathol. 2017 Sep;44(9):809-810 [28671710.001]
  • (PMID = 19996569.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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74. Stasek M, Spicka P, Zapletal P, Stefanicka D, Sisma P: [Non-pigmented subungual malignancies--crux chirurgiae minoris]. Rozhl Chir; 2009 Mar;88(3):147-50
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  • BACKGROUND: Incidence of amelanotic subungual malignancies is small, but they are not extremely rare and are often omitted in the diagnostic algorithm of subungual lesions.
  • METHODS: Retrospective analysis of four amelanotic subungual tumours--2 subungual melanomas and 2 spinocellular carcinomas.
  • There is fatal risk of delayed diagnosis especially in subungual melanoma cases, and mostly mutilation risk in spinocellular carcinoma cases.
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / surgery. Humans. Melanoma / diagnosis. Melanoma / surgery

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  • (PMID = 19526948.001).
  • [ISSN] 0035-9351
  • [Journal-full-title] Rozhledy v chirurgii : měsíčník Československé chirurgické společnosti
  • [ISO-abbreviation] Rozhl Chir
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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75. Ghariani N, Boussofara L, Kenani N, Ghannouchi N, Mebazaa A, Denguezli M, Belajouza C, Nouira R: Post traumatic amelanotic subungual melanoma. Dermatol Online J; 2008;14(1):13
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  • [Title] Post traumatic amelanotic subungual melanoma.
  • Subungual melanomas are rare; a delay in the diagnosis is common and is associated with advanced stage.
  • We report a case of subungual melanoma that was observed in an 86 year old man.
  • A direct role of the trauma in the pathogenesis of melanoma remains unclear.
  • [MeSH-major] Melanoma / pathology. Nail Diseases / pathology. Nails / injuries. Skin Neoplasms / pathology

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  • (PMID = 18319030.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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76. Stroh C, Manger T: [Primary amelanotic anorectal melanoma--a case report]. Zentralbl Chir; 2007 Dec;132(6):560-3
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  • [Title] [Primary amelanotic anorectal melanoma--a case report].
  • [Transliterated title] Das primäre amelanotische Melanom des Rektums - Ein Fallbericht.
  • BACKGROUND: The amelanotic melanoma of the rectal mucosa is very rare with an unfavourable prognosis.
  • METHODS: In literature 5 cases of amelanotic malignant melanoma were reported.
  • RESULTS: We report about a 55-year-old female patient with an amelanotic melanoma of rectal mucosa.
  • CONCLUSION: The prognosis of primary malignant anorectal melanoma is poor, irrespective of surgical treatment.
  • Wide local resection is the first choice for primary anorectal melanoma.
  • Chemotherapy, radiotherapy and immunotherapy should be considered in the treatment of anorectal melanoma to influence the overall survival.
  • [MeSH-major] Melanoma, Amelanotic / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. Disease Progression. Endosonography. Fatal Outcome. Female. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Intestinal Mucosa / ultrasonography. Lymph Node Excision. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Recurrence, Local / ultrasonography. Neoplasm Staging. Palliative Care. Proctoscopy. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 18098086.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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77. Sbano P, Nami N, Grimaldi L, Rubegni P: True amelanotic melanoma: the great masquerader. J Plast Reconstr Aesthet Surg; 2010 Mar;63(3):e307-8
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  • [Title] True amelanotic melanoma: the great masquerader.
  • [MeSH-major] Dermoscopy. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19713163.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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78. Jacob S, Pye E, Hbahbih M, Messios N, Rajabally YA: Rapidly progressive bilateral ophthalmoplegia and enlarging sellar mass caused by amelanotic melanoma. J Neuroophthalmol; 2006 Mar;26(1):49-50
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  • [Title] Rapidly progressive bilateral ophthalmoplegia and enlarging sellar mass caused by amelanotic melanoma.
  • Hypophysectomy disclosed an amelanotic melanoma.
  • There are seven reported cases of melanoma arising primarily in the sella turcica.
  • Two cases of metastatic melanoma to the cavernous sinuses have been reported.
  • Amelanotic melanoma has not been reported as a cause of cavernous sinus syndrome.
  • [MeSH-major] Melanoma, Amelanotic / complications. Ophthalmoplegia / etiology. Pituitary Neoplasms / complications. Sella Turcica / pathology
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Hypophysectomy. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16518168.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Said A, Tundis R, Hawas UW, El-Kousy SM, Rashed K, Menichini F, Bonesi M, Huefner A, Loizzo MR, Menichinib F: In vitro antioxidant and antiproliferative activities of flavonoids from Ailanthus excelsa (Roxb.) (Simaroubaceae) leaves. Z Naturforsch C; 2010 Mar-Apr;65(3-4):180-6
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  • Compounds 1 and 3 inhibited cell growth in both amelanotic melanoma and malignant melanoma cells.

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  • (PMID = 20469635.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Biphenyl Compounds; 0 / Flavonoids; 0 / Free Radical Scavengers; 0 / Picrates; 1898-66-4 / 2,2-diphenyl-1-picrylhydrazyl
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80. Zaballos P, Carulla M, Ozdemir F, Zalaudek I, Bañuls J, Llambrich A, Puig S, Argenziano G, Malvehy J: Dermoscopy of pyogenic granuloma: a morphological study. Br J Dermatol; 2010 Dec;163(6):1229-37
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  • BACKGROUND: Pyogenic granuloma is a common, benign, vascular lesion of the skin and mucous membranes which is a simulator of amelanotic/hypomelanotic melanoma and other tumours.
  • METHODS: Digital dermoscopic images of histopathologically proven cases of 122 pyogenic granulomas and 140 other tumours (28 amelanotic melanomas, seven melanoma metastases, 22 basal cell carcinomas and 83 other tumours) were collected from university hospitals in Spain, Italy, Austria and Turkey.
  • Two other patterns (RHA + WC and RHA + WC + WRL + VS) showed 100% specificity when compared with melanoma (P < 0·001 and P < 0·05, respectively).
  • CONCLUSIONS: Even though some dermoscopic patterns are useful in the recognition of pyogenic granulomas, dermoscopy is not a substitute for histology, mostly when vessels are present, as melanoma cannot be ruled out.

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20846306.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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81. Harasymowycz P, Boucher MC, Corriveau C, Gauthier D, Allaire G: Choroidal amelanotic melanoma in a patient with oculocutaneous albinism. Can J Ophthalmol; 2005 Dec;40(6):754-8
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  • [Title] Choroidal amelanotic melanoma in a patient with oculocutaneous albinism.
  • CASE REPORT: We describe the clinical presentation of a choroidal amelanotic melanoma in a 46-year-old woman with oculocutaneous albinism.
  • Microscopic findings and histopathological features, demonstrating a spindle B-cell melanoma of the choroid, are also reviewed.
  • COMMENTS: Magnetic resonance imaging may be helpful in diagnosing amelanotic melanoma in patients with oculocutaneous albinism.

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  • (PMID = 16391642.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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82. Harrison TM, Dominguez P, Hanzlik K, Sikarskie JG, Agnew D, Bergin I, Fitzgerald SD, Kitchell BE, McNiel E: Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi). J Zoo Wildl Med; 2010 Mar;41(1):152-7
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  • [Title] Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi).
  • Immunohistochemically, the original, recurrent, and metastatic populations were strongly positive for HMB 45 and weakly positive for S-100, and the final diagnosis was metastatic amelanotic melanoma.
  • [MeSH-major] Insectivora. Melanoma, Amelanotic / veterinary

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  • (PMID = 20722271.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Cavicchini S, Tourlaki A, Bottini S: Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma. Arch Dermatol; 2007 Apr;143(4):556
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  • [Title] Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / blood supply. Skin Neoplasms / blood supply

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  • (PMID = 17438200.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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84. Pouckova P, Skvor J, Gotte G, Vottariello F, Slavik JT, Matousek J, Laurents DV, Libonati M, Soucek J: Some biological actions of PEG-conjugated RNase A oligomers. Neoplasma; 2006;53(1):79-85
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  • In this work we show that the chemical conjugation of PEG to the RNase A C-dimer, and to the two RNase A trimers (NC-trimer and C- trimer) decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB900518 amelanotic melanoma transplanted in athymic nude mice.
  • [MeSH-minor] Animals. Antispermatogenic Agents / pharmacology. Cell Line, Tumor. Dimerization. Embryo, Mammalian / drug effects. Humans. Male. Melanoma, Experimental / drug therapy. Mice. Neoplasm Transplantation. Spermatogenesis / drug effects

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  • (PMID = 16416018.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antispermatogenic Agents; 0 / Peptide Fragments; 30IQX730WE / Polyethylene Glycols; EC 3.1.27.5 / Ribonuclease, Pancreatic
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85. Koszałka P, Szmit E, Myśliwski A, Bigda J: Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters. Arch Immunol Ther Exp (Warsz); 2007 Jul-Aug;55(4):267-79
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  • [Title] Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters.
  • MATERIALS AND METHODS: The effects of intratumoral injection of rat TNF into hamsters bearing Bomirski Ab amelanotic melanoma, a fast growing tumor of high metastatic potential, were tested.
  • In vitro assays indicated a direct cytotoxic effect of TNF against Ab melanoma cells, most probably as an outcome of apoptosis.
  • Intratumoral application of TNF also caused some modulation of cytokine response in melanoma-bearing hamsters as evidenced by increased levels of IL-6 in blood serum.
  • CONCLUSIONS: This study established Bomirski Ab melanoma as a useful model for complex analysis of the anti-tumor activity of TNF.
  • [MeSH-major] Angiogenesis Inhibitors / metabolism. Melanoma, Experimental / metabolism. Neovascularization, Pathologic / metabolism. Recombinant Proteins / metabolism. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17659374.001).
  • [ISSN] 0004-069X
  • [Journal-full-title] Archivum immunologiae et therapiae experimentalis
  • [ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Cyclohexanes; 0 / Interleukin-6; 0 / Recombinant Proteins; 0 / Sesquiterpenes; 0 / Tumor Necrosis Factor-alpha; 129298-91-5 / O-(chloroacetylcarbamoyl)fumagillol
  • [Other-IDs] NLM/ PMC2766459
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86. Cahill S, Cryer JR, Otter SJ, Ramesar K: An amelanotic malignant melanoma masquerading as hypergranulation tissue. Foot Ankle Surg; 2009;15(3):158-60
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  • [Title] An amelanotic malignant melanoma masquerading as hypergranulation tissue.
  • We report a case of amelanotic malignant melanoma occurring in the nail sulcus of the hallux, which on initial presentation was mistaken for hypergranulation tissue due to an in-growing toenail.
  • [MeSH-major] Melanoma / physiopathology. Melanoma / surgery. Skin Neoplasms / physiopathology. Skin Neoplasms / surgery

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  • (PMID = 19635427.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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87. Nabeshima T, Kimura K, Kurosaka D: Amelanotic malignant melanoma of the conjunctiva in a young adult. Jpn J Ophthalmol; 2008 Sep-Oct;52(5):407-8
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  • [Title] Amelanotic malignant melanoma of the conjunctiva in a young adult.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanoma, Amelanotic / pathology

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  • (PMID = 18991044.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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88. Ghiorzo P, Pastorino L, Pizzichetta MA, Bono R, Queirolo P, Talamini R, Annessi G, Bruno W, Nasti S, Gargiulo S, Battistuzzi L, Sini MC, Palmieri G, Scarrà GB, Italian Melanoma Intergroup: CDKN2A and MC1R analysis in amelanotic and pigmented melanoma. Melanoma Res; 2009 Jun;19(3):142-5
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  • [Title] CDKN2A and MC1R analysis in amelanotic and pigmented melanoma.
  • Amelanotic melanoma (AM) is a rare subtype of melanoma with little or no clinically visible pigment; it is more difficult to diagnose than pigmented melanoma (PM), and has a worse prognosis.
  • In the attempt to find a genetic explanation for the distinction between AM and PM, we conducted a case-case study, matching AM and PM patients, and testing them for germline mutations in high- (p16INK4A, p14ARF, CDK4) and low-penetrance (MC1R) melanoma susceptibility genes.
  • Similar CDKN2A mutations were found in both sets of melanomas.
  • A p14ARF splice germline mutation was detected for the first time in an Italian family with AM.
  • This rare mutation, which has been described only once previously, may be involved in predisposition to the amelanotic phenotype in combination with germline MC1R variants and coordinate somatic expression of pigmentation genes and their regulators.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Melanoma, Amelanotic / genetics. Receptor, Melanocortin, Type 1 / genetics. Skin Neoplasms / genetics. Tumor Suppressor Protein p14ARF / genetics
  • [MeSH-minor] Alternative Splicing. Female. Genetic Predisposition to Disease. Humans. Italy / epidemiology. Male. Mutation / genetics. Pedigree. Penetrance. Pigmentation / genetics

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  • (PMID = 19339902.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Receptor, Melanocortin, Type 1; 0 / Tumor Suppressor Protein p14ARF
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89. Mesa M, Quesada JL, Piñas J: Metastasis of amelanotic melanoma of unknown origin in the parotid gland. Br J Oral Maxillofac Surg; 2009 Oct;47(7):569-71
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  • [Title] Metastasis of amelanotic melanoma of unknown origin in the parotid gland.
  • We report a rare case of metastasis of an amelanotic melanoma of the parotid gland.
  • To our knowledge this is the first report of a metastasis of an amelanotic melanoma in a parotid lymph node.
  • [MeSH-major] Melanoma, Amelanotic / secondary. Neoplasms, Unknown Primary / pathology. Parotid Neoplasms / secondary
  • [MeSH-minor] Aged. Antigens, Neoplasm / analysis. Biopsy, Fine-Needle. Female. Humans. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. S100 Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 19167137.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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90. Gelpi E, Popovic M, Preusser M, Budka H, Hainfellner J: Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis. Neuropathology; 2005 Sep;25(3):241-6
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  • In these cases, the differential diagnosis needs to exclude other malignancies, for example, glioblastoma or malignant fibrous histiocytoma.
  • These features led to the tentative diagnosis of amelanotic melanoma, and the patient was irradiated.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry / methods. Melanoma / pathology. Microscopy, Confocal. Microscopy, Electron, Transmission. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16193842.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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91. Nakamoto T, Inoue Y, Ueki T, Niimi N, Iwasaki Y: Primary amelanotic malignant melanoma of the female urethra. Int J Urol; 2007 Feb;14(2):153-5
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  • [Title] Primary amelanotic malignant melanoma of the female urethra.
  • The case is reported of amelanotic malignant melanoma of the female urethra mimicking urethral caruncle.
  • Urethral carunclectomy was performed, but histological diagnosis was amelanotic malignant melanoma.
  • [MeSH-major] Melanoma, Amelanotic. Urethral Neoplasms

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  • (PMID = 17302574.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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92. Grenader T, Isacson R, Reinus C, Rosengarten O, Barenholz O, Hyman J, Gabizon A, Beller U: Primary amelanotic melanoma of the vagina. Onkologie; 2008 Sep;31(8-9):474-6
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  • [Title] Primary amelanotic melanoma of the vagina.
  • BACKGROUND: Primary malignant melanoma of the vagina is extremely rare, accounting for 0.3-0.8% of all malignant melanomas.
  • True amelanotic vaginal melanoma showing no melanin on histological examination is exceedingly rare, accounting for only 2% of all vaginal melanomas.
  • CASE REPORT: We describe a 31-year-old female patient who presented with locally advanced amelanotic melanoma of the vagina, with no evidence of metastatic spread on the computerized tomography (CT) scan, but who was subsequently diagnosed as suffering from metastatic disease by positron emission tomography (PET)-CT performed a few weeks following posterior pelvic exenteration.
  • CONCLUSION: Specific immunohistochemical staining with melanoma markers should be performed to confirm or exclude a diagnosis of amelanotic melanoma in all patients presenting with a vaginal mass composed of undifferentiated epithelioid malignant cells.
  • Fluorodeoxyglucose (FDG)-PET-CT should be performed as part of the preoperative evaluation, to identify the presence or absence of metastatic disease in all patients with vaginal melanoma.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / surgery. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / surgery

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18787356.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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93. Cichorek M, Kozłowska K, Wachulska M, Zielińska K: Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. Folia Histochem Cytobiol; 2006;44(1):31-6
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  • [Title] Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth.
  • Since the spontaneous alteration of native melanotic (Ma) into amelanotic (Ab) transplantable melanoma line it has been observed that this alteration is accompanied by the acceleration of growth of Ab line.
  • Apoptosis estimated by the TUNEL method, alterations in the plasma membrane structure (annexin V staining), changes in the mitochondrial transmembrane potential--delta psi m (JC-1 staining) showed that amelanotic melanoma cells have decreased ability to undergo spontaneous apoptosis.
  • The obtained results showing that in the native melanotic line about 30% of cells are in S+G2/M phases and that 33% of these cells undergo apoptosis could lead to the conclusion that the slower growth of this melanoma line is the result of lower proliferation activity and higher rate of apoptosis of these tumor cells.
  • The number of cells in S+G2/M phases in amelanotic melanoma line increases up to 40% and only 7% of them undergo apoptosis.
  • This observation seems to suggest that the expansive growth of this melanoma line depends mainly on the decreased ability to undergo spontaneous apoptosis, especially in case of cells from S+G2/M phases.
  • Moreover, the obtained results indicate that alteration of melanotic line into amelanotic one, accompanied by differences in many biological features also concerns basic cell processes such as cell cycle and cell death.

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  • (PMID = 16584089.001).
  • [ISSN] 0239-8508
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Phosphatidylserines
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94. Panasiti V, Devirgiliis V, Curzio M, Roberti V, Gobbi S, Masciangelo R, Mastrecchia B, Calvieri S, Bottoni U: The reticular point of view in dermatoscopy. J Am Acad Dermatol; 2009 Oct;61(4):605-10
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  • We sought to develop and evaluate a diagnostic scoring system, the reticular point of view, to distinguish common melanocytic nevus from dysplastic nevus and from melanoma.
  • RESULTS: Among the lesions excised, histopathologic examination revealed 33 (10.28%) melanomas.
  • Regarding the diagnosis of melanoma, only the presence of large holes, areas of abrupt cut off, and linear extensions revealed statistical significance.
  • It is not applicable in nodular, thick, and amelanotic melanomas that are usually lacking in pigment network.
  • CONCLUSION: Although pattern analysis represents the most effective analytical method in dermatoscopy, our scoring system may be useful to distinguish between benign lesions, which need only clinical follow-up, and malignant lesions, which need surgical excision.
  • [MeSH-major] Algorithms. Dermoscopy / methods. Dysplastic Nevus Syndrome / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19703721.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Sinicropi MS, Caruso A, Conforti F, Marrelli M, El Kashef H, Lancelot JC, Rault S, Statti GA, Menichini F: Synthesis, inhibition of NO production and antiproliferative activities of some indole derivatives. J Enzyme Inhib Med Chem; 2009 Oct;24(5):1148-53
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  • The compounds prepared were evaluated for their inhibition of NO production, antioxidant activity and also for their ability to inhibit in vitro the growth of four human tumor cell lines: large lung carcinoma (COR-L23), alveolar basal epithelial carcinoma (A549), amelanotic melanoma (C32) and melanoma (A375).
  • Compound 5a was the most active against melanotic melanoma (IC(50) = 11.8 microM) while the other compounds exhibited weak cytotoxicity with IC(50) values >50 microM on all cell lines.

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  • (PMID = 19555184.001).
  • [ISSN] 1475-6374
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Pyrans; 31C4KY9ESH / Nitric Oxide
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96. Rizvi SA, Amitava AK, Mehdi G, Sharma R, Alam MS: Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association. Indian J Ophthalmol; 2008 Sep-Oct;56(5):421-3
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  • [Title] Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association.
  • Ocular neoplasms occurring in XP in order of frequency are squamous cell carcinoma, basal cell carcinoma and melanoma.
  • Malignant melanomas occur at an early age in patients with XP.
  • We report a case of XP with massive orbital melanoma in an eight-year-old boy which is unique due to its amelanotic presentation confirmed histopathologically.
  • [MeSH-major] Melanoma, Amelanotic / complications. Orbit. Skin Neoplasms / complications. Xeroderma Pigmentosum / complications

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  • (PMID = 18711275.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2636150
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97. Silver EA, Hofmann AE, Williams D, Srolovitz H, Tahiri Y, Khanna M: Large amelanotic melanoma and vitiligo. Arch Dermatol; 2009 Oct;145(10):1198-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large amelanotic melanoma and vitiligo.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Palliative Care. Skin Neoplasms / pathology. Vitiligo / diagnosis


98. Arevalo A, Altamura D, Avramidis M, Blum A, Menzies S: The significance of eccentric and central hyperpigmentation, multifocal hyper/hypopigmentation, and the multicomponent pattern in melanocytic lesions lacking specific dermoscopic features of melanoma. Arch Dermatol; 2008 Nov;144(11):1440-4
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  • [Title] The significance of eccentric and central hyperpigmentation, multifocal hyper/hypopigmentation, and the multicomponent pattern in melanocytic lesions lacking specific dermoscopic features of melanoma.
  • OBJECTIVE: To examine the significance of eccentric hyperpigmentation (EH), central hyperpigmentation (CH), multifocal hyper/hypopigmentation (MH/HP), and the multicomponent pattern (MCP) in melanocytic lesions lacking specific dermoscopic features of melanoma.
  • DESIGN: A total of 3367 benign and malignant melanocytic lesions (n = 341 melanomas, excluding lentigo maligna and lentigo maligna melanoma) were examined to identify those lesions lacking specific dermoscopic features of melanoma but having any of the global patterns of EH, CH, MH/HP, and MCP.
  • SETTING: Dermoscopic images were collected from lesions excised or undergoing sequential digital monitoring from the Sydney Melanoma Diagnostic Centre, a tertiary referral institution located in Sydney, Australia.
  • MAIN OUTCOME MEASURE: The odds ratio (OR) for melanoma of EH, CH, MH/HP, and MCP.
  • RESULTS: While EH (OR, 3.3; 95% confidence interval [CI], 2.5-4.6) and MCP (OR, 15.4; 95% CI, 11.9-19.9) were significant predictors of melanoma when total melanomas vs nevi were analyzed, there was no significant difference between the frequency of any of the global patterns in melanomas vs benign nevi lacking specific dermoscopic features of melanoma.
  • CONCLUSION: Based on our study results and previous prevalence data on these global patterns in benign nevi, we do not believe that lesions with EH or MCP require closer observation than other benign nevi lacking specific dermoscopic features of melanoma.
  • [MeSH-major] Dermoscopy. Hyperpigmentation / pathology. Hypopigmentation / pathology. Melanoma / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Australia. Biopsy, Needle. Cohort Studies. Confidence Intervals. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology. Observer Variation. Odds Ratio. Probability. Registries. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity


99. Siddaraju N, Yaranal PJ, Mishra MM, Soundararaghavan J: Fine needle aspiration cytology in recurrent amelanotic melanoma: a case report. Acta Cytol; 2007 Sep-Oct;51(5):829-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology in recurrent amelanotic melanoma: a case report.
  • BACKGROUND: Amelanotic melanoma can mimic a wide variety of epithelial and nonepithelial malignant tumors.
  • Varied cytomorphology of melanoma has been described on exfoliative and fine needle aspiration cytology (FNAC).
  • We report a case of recurrent amelanotic melanoma to highlight its varied cytomorphologic features, which may cause diagnostic problems on cytologic and on histologic examinations.
  • FNAC revealed malignant cells with highly varied morphology with plasmacytoid and pleomorphic malignant cells with occasional fibrocollagenous tissue strands showing adherent neoplastic cells.
  • A cytologic diagnosis of pleomorphic malignant tumor was suggested, and the original histologic slides were reviewed; they showed a striking alveolar pattern that vaguely resembled an alveolar rhabdomyosarcoma.
  • A final diagnosis of amelanotic melanoma was made.
  • CONCLUSION: Awareness of the highly varied cytomorphology of amelanotic melanoma minimizes the diagnostic difficulty on fine needle aspiration smears.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Skin Cancer.
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  • (PMID = 17910357.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Menichini F, Tundis R, Loizzo MR, Bonesi M, Provenzano E, de Cindio B, Menichini F: In vitro photo-induced cytotoxic activity of Citrus bergamia and C. medica L. cv. Diamante peel essential oils and identified active coumarins. Pharm Biol; 2010 Sep;48(9):1059-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In order to evaluate the cytotoxic activity two melanoma models, such as amelanotic melanoma C32 and malignant melanoma A375, were used.
  • This phototoxicity may be considered as a treatment option in some cases of lentigo maligna or lentigo maligna melanoma.
  • [MeSH-minor] Cell Line, Tumor. Cell Survival / drug effects. Cell Survival / radiation effects. Drug Discovery. Drug Evaluation, Preclinical. Gas Chromatography-Mass Spectrometry. Humans. Inhibitory Concentration 50. Melanoma / drug therapy. Melanoma, Amelanotic / drug therapy. Methoxsalen / analogs & derivatives. Methoxsalen / analysis. Methoxsalen / chemistry. Methoxsalen / pharmacology. Methoxsalen / radiation effects. Photochemotherapy. Phytotherapy. Time Factors. Ultraviolet Rays

  • Hazardous Substances Data Bank. 8-METHOXYPSORALEN .
  • Hazardous Substances Data Bank. 5-METHOXYPSORALEN .
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  • (PMID = 20690896.001).
  • [ISSN] 1744-5116
  • [Journal-full-title] Pharmaceutical biology
  • [ISO-abbreviation] Pharm Biol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Coumarins; 0 / Oils, Volatile; 4FVK84C92X / 5-methoxypsoralen; JWE1QQ247N / 5,7-dimethoxycoumarin; U4VJ29L7BQ / Methoxsalen
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