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1. Zielińska K, Kozłowska K, Cichorek M, Wachulska M: Fas and FasL expression on cells of two transplantable melanoma lines according to their different biological properties. Folia Histochem Cytobiol; 2008;46(3):337-43
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  • [Title] Fas and FasL expression on cells of two transplantable melanoma lines according to their different biological properties.
  • In tumours (e.g. melanoma), FasL expression possibly counteracts the Fas-positive effector T cells that infiltrate into tumours, and consequently the Fas/FasL interaction can contribute to the escape of tumour cells from the systemic immune response.
  • In this study we examined differences in Fas and FasL expression on cells from the hamster melanotic melanoma line (Ma) and a more aggressive amelanotic melanoma line (Ab).
  • We also tried to find out whether the Fas/FasL expression induces an ability to undergo spontaneous apoptosis in these two transplantable melanoma lines.
  • Isolated transplantable melanoma cells were incubated for 4 and 24 hours and after that time the expression of Fas and FasL was estimated by flow cytometry.
  • The results show that there was no Fas expression, although FasL was detected on both melanoma cell lines.
  • Therefore the data reported by other authors indicate that a lack or a low level of Fas expression and an ectopic expression of FasL on melanoma cells can be an escape mechanism of the tumour, to avoid host immune responses.
  • The content of FasL-positive melanotic melanoma cells was higher than in amelanotic melanoma cells and increased with the prolongation of the incubation time.
  • FasL expression on amelanotic melanoma cells was detected after 24 hours at a level similar to that on melanotic melanoma cells after 4 hours incubation time.
  • FasL expression on melanoma cells can induce apoptosis in cytotoxic T lymphocytes and NK cells which are responsible for tumour cells elimination.
  • The results obtained suggest that the Fas/FasL system does not play any significant role in spontaneous apoptosis of two melanoma cell lines.

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  • (PMID = 19056538.001).
  • [ISSN] 1897-5631
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Fas Ligand Protein
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2. Grenader T, Isacson R, Reinus C, Rosengarten O, Barenholz O, Hyman J, Gabizon A, Beller U: Primary amelanotic melanoma of the vagina. Onkologie; 2008 Sep;31(8-9):474-6
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  • [Title] Primary amelanotic melanoma of the vagina.
  • BACKGROUND: Primary malignant melanoma of the vagina is extremely rare, accounting for 0.3-0.8% of all malignant melanomas.
  • True amelanotic vaginal melanoma showing no melanin on histological examination is exceedingly rare, accounting for only 2% of all vaginal melanomas.
  • CASE REPORT: We describe a 31-year-old female patient who presented with locally advanced amelanotic melanoma of the vagina, with no evidence of metastatic spread on the computerized tomography (CT) scan, but who was subsequently diagnosed as suffering from metastatic disease by positron emission tomography (PET)-CT performed a few weeks following posterior pelvic exenteration.
  • CONCLUSION: Specific immunohistochemical staining with melanoma markers should be performed to confirm or exclude a diagnosis of amelanotic melanoma in all patients presenting with a vaginal mass composed of undifferentiated epithelioid malignant cells.
  • Fluorodeoxyglucose (FDG)-PET-CT should be performed as part of the preoperative evaluation, to identify the presence or absence of metastatic disease in all patients with vaginal melanoma.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / surgery. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / surgery

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18787356.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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3. Nejc D, Piekarski J, Pasz-Walczak G, Wroński K, Pluta P, Jeziorski A: The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. Melanoma Res; 2005 Dec;15(6):565-9
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  • [Title] The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis.
  • We present the first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis.
  • Pathologic examination of the postoperative specimen revealed the presence of a very rare malignancy--amelanotic melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Penile Neoplasms / pathology

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  • (PMID = 16314746.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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4. Wachulska M, Kozłowska K, Cichorek M: The DNA ploidy and proliferative activity of transplantable melanoma cells in regard to their secretory function. Neoplasma; 2005;52(4):280-6
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  • [Title] The DNA ploidy and proliferative activity of transplantable melanoma cells in regard to their secretory function.
  • The study concerns DNA ploidy and proliferative activity of the cells of two hamster transplantable melanoma lines - differing in many biological features - in the light of possible changes in their secretory activity.
  • Our results indicate that melanotic melanoma cells (Ma) have a near-tetraploid DNAcontent and about 18% of proliferating cells, while amelanotic melanoma cells (Ab) - have a near-triploid DNA content and almost twice as many proliferating cells.
  • The Ab cells, in comparison with Ma cells, secreted in vitro less total protein and most of the cytokines examined except OSM, but a spontaneous alteration of transplantable melanoma was accompanied by an increase of the quantity and dynamics of NO secretion.
  • So, the cells of two melanoma lines have their own characteristic pattern of secretory function.
  • But, the aneuploidy which accompanied the changes in cell differentiation of the studied melanoma lines, although seemed to reflect their changes in the proliferative activity, nevertheless did not reflect, in a direct way, differences in the secretion of the substances studied.
  • [MeSH-major] DNA, Neoplasm / analysis. Melanoma / pathology. Melanoma / secretion. Ploidies. Skin Neoplasms / pathology. Skin Neoplasms / secretion


5. Mensing C, Livingstone E, Schwarz T, Hauschild A: Eczematous malignant melanoma: a wolf in sheep's clothing. Onkologie; 2009 Apr;32(4):206-8
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  • [Title] Eczematous malignant melanoma: a wolf in sheep's clothing.
  • BACKGROUND: The clinical diagnosis of amelanotic melanoma is still a challenge.
  • CASE REPORT: A 72-year-old patient was first referred to us for the excision of a melanoma of the chin.
  • In the first examination, we discovered another melanoma of the trunk.
  • Both malignancies were excised and histopathology confirmed the clinical diagnosis of melanomas with Clark level II and III, respectively.
  • Surprisingly, the pathology report showed typical features of a malignant melanoma.
  • The diagnosis was confirmed by 3 further punch biopsies (Clark level III, Breslow 0.6 mm).
  • CONCLUSIONS: Amelanotic melanoma may appear as an erythematous macula or plaque; clinical symptoms are erythema, edema, pruritus or a slow increase in size and hypopigmentation or discoloration.
  • [MeSH-major] Eczema / diagnosis. Eczema / etiology. Melanoma / complications. Melanoma / diagnosis. Skin Neoplasms / complications. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19372718.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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6. Cahill S, Cryer JR, Otter SJ, Ramesar K: An amelanotic malignant melanoma masquerading as hypergranulation tissue. Foot Ankle Surg; 2009;15(3):158-60
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  • [Title] An amelanotic malignant melanoma masquerading as hypergranulation tissue.
  • We report a case of amelanotic malignant melanoma occurring in the nail sulcus of the hallux, which on initial presentation was mistaken for hypergranulation tissue due to an in-growing toenail.
  • We highlight the importance of this differential diagnosis as such lesions can have serious sequelae.
  • [MeSH-major] Melanoma / physiopathology. Melanoma / surgery. Skin Neoplasms / physiopathology. Skin Neoplasms / surgery

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  • (PMID = 19635427.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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7. Patel GA, Ragi G, Krysicki J, Schwartz RA: Subungual melanoma: a deceptive disorder. Acta Dermatovenerol Croat; 2008;16(4):236-42
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  • [Title] Subungual melanoma: a deceptive disorder.
  • Subungual melanoma is an uncommon form of acral melanoma that arises within the nail bed.
  • Up to 33% of subungual melanomas are amelanotic.
  • Non-specific features and symptoms along with a high incidence of amelanosis often lead to delayed diagnosis, disease progression, and a poor prognosis with challenging treatment options.
  • [MeSH-major] Melanoma / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19111151.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 40
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8. Nihal M, Ahmad N, Mukhtar H, Wood GS: Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. Int J Cancer; 2005 Apr 20;114(4):513-21
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  • [Title] Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma.
  • Melanoma accounts for only about 4% of all skin cancer cases but most of skin cancer-related deaths.
  • Standard systemic therapies such as interferon (IFN) have not been adequately effective in the management of melanoma.
  • Chemoprevention by naturally occurring agents present in food and beverages has shown benefits in certain cancers including nonmelanoma skin cancers.
  • Here, employing 2 human melanoma cell lines (A-375 amelanotic malignant melanoma and Hs-294T metastatic melanoma) and normal human epidermal melanocytes (NHEM), we studied the antiproliferative effects of epigallocatechin-3-gallate (EGCG), the major polyphenolic antioxidant present in green tea.
  • EGCG treatment was found to result in a dose-dependent decrease in the viability and growth of both melanoma cell lines.
  • EGCG treatment of the melanoma cell lines resulted in decreased cell proliferation (as assessed by Ki-67 and PCNA protein levels) and induction of apoptosis (as assessed cleavage of PARP, TUNEL assay and JC-1 assay).
  • EGCG also significantly inhibited the colony formation ability of the melanoma cells studied.
  • EGCG treatment of melanoma cells resulted in a downmodulation of anti-apoptotic protein Bcl2, upregulation of proapoptotic Bax and activation of caspases -3, -7 and -9.
  • Our data suggest that EGCG causes significant induction of cell cycle arrest and apoptosis of melanoma cells that is mediated via modulations in the cki-cyclin-cdk network and Bcl2 family proteins.
  • Thus, EGCG, alone or in conjunction with current therapies, could be useful for the management of melanoma.
  • [MeSH-major] Anticarcinogenic Agents / pharmacology. Apoptosis. Catechin / analogs & derivatives. Catechin / pharmacology. Melanoma / drug therapy. Melanoma / prevention & control

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  • (PMID = 15609335.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR002136-06
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / BAX protein, human; 0 / CDKN1A protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; 8R1V1STN48 / Catechin; 9002-18-0 / Agar; BQM438CTEL / epigallocatechin gallate; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / CASP7 protein, human; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 7; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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9. Manganoni AM, Farisoglio C, Tucci G, Facchetti F, Ungari M, Calzavara-Pinton PG: Thin primary cutaneous melanoma in childhood and adolescence: report of 12 cases. Pediatr Dermatol; 2009 May-Jun;26(3):356-7
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  • [Title] Thin primary cutaneous melanoma in childhood and adolescence: report of 12 cases.
  • Approximately, 1-4% of all new melanoma cases occur in patients younger than 20 years.
  • The clinical presentation of melanoma in the young is often challenging.
  • We report the experience of the Melanoma Unit of University Hospital Spedali Civili of Brescia, Italy.
  • Study subjects were drawn from 1470 patients with histologically confirmed melanoma.
  • From this group, melanoma developed in 12 patients younger than 19 years.
  • For each melanoma diagnosed, histologic characteristics, treatment, and outcomes were evaluated.
  • In many cases reported in literature lesions are amelanotic, nodular, and resemble pyogenic granuloma.
  • From our case studies it was found that the clinical characteristics detected in melanomas diagnosed in childhood and adolescence have been the same as those described in adults and that the ABCDE clinical criteria may be helpful basics of melanoma.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19706109.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Tolleson WH, Doss JC, Latendresse J, Warbritton AR, Melchior WB Jr, Chin L, Dubielzig RR, Albert DM: Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. Arch Ophthalmol; 2005 Aug;123(8):1088-94
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  • [Title] Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
  • OBJECTIVE: To characterize a murine model of spontaneous amelanotic melanoma arising in the uvea of transgenic mice bearing a targeted deletion of the Ink4a/Arf tumor suppressor locus (exons 2 and 3) and expressing human H-ras controlled by the human tyrosinase promoter.
  • CONCLUSION: Spontaneous uveal malignant melanomas occurring in male Tyr-RAS+ Ink4a/Arf-/- transgenic mice arise within the choroid or ciliary body and share histopathological features characteristic of human uveal melanoma.
  • CLINICAL RELEVANCE: Uveal melanoma research has benefited from xenograft models, but engineered mouse models of spontaneous uveal amelanotic melanoma will undoubtedly further our understanding of the genetic underpinning for this disease.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Gene Deletion. Genes, ras / genetics. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / genetics. Tumor Suppressor Protein p14ARF / genetics. Uveal Neoplasms / pathology

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  • (PMID = 16087843.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 01917; United States / NCI NIH HHS / CA / R01 CA 93947
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; EC 1.14.18.1 / Monophenol Monooxygenase
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11. Abe Y, Takeuchi M, Matsuzaki K, Uehara H, Furumoto H, Nishitani H: A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging. Jpn J Radiol; 2009 Dec;27(10):458-61
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  • [Title] A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging.
  • Ovarian metastasis from malignant melanoma is rare and usually appears as a solid ovarian mass.
  • We report a case of ovarian metastasis from cutaneous malignant melanoma that proved to be a diagnostic dilemma.
  • [MeSH-major] Magnetic Resonance Imaging. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / secondary. Ovarian Cysts / diagnosis. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Ascites / etiology. Diagnosis, Differential. Fatal Outcome. Female. Gadolinium. Humans. Melanoma / diagnosis. Melanoma / secondary. Time Factors. Treatment Outcome


12. Ashidi JS, Houghton PJ, Hylands PJ, Efferth T: Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves. J Ethnopharmacol; 2010 Mar 24;128(2):501-12
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  • Three cancer cell lines (human breast adenocarcinoma cell line MCF-7, human large cell lung carcinoma cell line COR-L23 and human amelanotic melanoma C32) and one normal cell line (normal human keratinocytes SVK-14) were used for the screening of the extracts and the fractions obtained.

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20064598.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Flavanones; 0 / Sitosterols; 0 / pinostrobin; 5LI01C78DD / gamma-sitosterol; 6SMK8R7TGJ / Oleanolic Acid; KM8353IPSO / amyrin
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13. Yeşil S, Demir T, Akinci B, Pabuccuoglu U, Ilknur T, Saklamaz A: Amelanotic melanoma misdiagnosed as a diabetic foot ulcer. J Diabetes Complications; 2007 Sep-Oct;21(5):335-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amelanotic melanoma misdiagnosed as a diabetic foot ulcer.
  • Amelanotic melanoma often leads to delayed clinical diagnosis because of its wide range of clinical appearances and lack of pigmentation.
  • Misdiagnosis of amelanotic melanoma is also common, particularly when it is located at the foot.
  • Further investigation of the patient in our clinic revealed plantar amelanotic melanoma.
  • [MeSH-major] Diabetic Foot / diagnosis. Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diabetic Angiopathies / diagnosis. Diagnostic Errors. Hemoglobin A, Glycosylated / metabolism. Humans. Male

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  • (PMID = 17825759.001).
  • [ISSN] 1056-8727
  • [Journal-full-title] Journal of diabetes and its complications
  • [ISO-abbreviation] J. Diabetes Complicat.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobin A, Glycosylated
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14. Arican O, Sasmaz S, Coban YK, Ciralik H: Subungual amelanotic malignant melanoma. Saudi Med J; 2006 Feb;27(2):247-9
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  • [Title] Subungual amelanotic malignant melanoma.
  • Histopathological examination of toenail specimen revealed the presence of nests of atypical tumor cells that led to the diagnosis of amelanotic malignant melanoma.
  • We presented a case of subungual amelanotic melanoma, as it is rare disease, early and correct diagnosis is very important.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 16501687.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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15. Ishii H, Joshita T, Matsuyama N, Uchida T, Ishikawa A, Ebihara Y: Immunohistochemical and ultrastructural investigation on cutaneous neuroendocrine carcinoma: report of a case and review of the literature. Med Mol Morphol; 2006 Sep;39(3):164-8
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  • We report a tumor in an 80-year-old man that was difficult to distinguish from other tumors, i.e., small cell carcinoma of the lung, PNET/Ewing tumor, malignant lymphoma, or malignant melanoma (amelanotic), and which was finally identified as cutaneous neuroendocrine carcinoma using immunohistochemical and ultrastructural methods.
  • Immunohistochemistry tests gave negative results for LCA, UCHL-1, CD3, and CD20, thereby excluding malignant lymphoma, and the negative results for S-100 protein and HMB-45 ruled out malignant melanoma.
  • We therefore diagnosed the primary carcinoma of the skin as cutaneous neuroendocrine carcinoma.
  • [MeSH-major] Carcinoma, Neuroendocrine / ultrastructure. Skin Neoplasms / ultrastructure
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Fatal Outcome. Humans. Immunohistochemistry. Male

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  • [Cites] Histopathology. 1992 May;20(5):437-9 [1587495.001]
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  • (PMID = 16998628.001).
  • [ISSN] 1860-1480
  • [Journal-full-title] Medical molecular morphology
  • [ISO-abbreviation] Med Mol Morphol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Castillo O, Frisancho O, Palomino A: [Cecal amelanotic melanoma]. Rev Gastroenterol Peru; 2010 Oct-Dec;30(4):368-71
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  • [Title] [Cecal amelanotic melanoma].
  • [Transliterated title] Melanoma amelanótico en ciego.
  • Subsequently, we confirmed the presence of red blood in stools, like enterorrhagia and underwent a colonoscopy, in which two elevated lesions were found in the cecum: a pedunculated (with active bleeding, oozing) and other sessile; both were removed. the pathology showed that corresponded to amelanotic melanoma in cecal region.
  • Physical examination revealed no malignant skin lesions.
  • We report this case, because gastrointestinal bleeding is an unusual clinical presentation of malignant melanoma.
  • [MeSH-major] Cecal Neoplasms / pathology. Melanoma / pathology

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  • (PMID = 21263766.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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17. Frankenthaler A, Sullivan RJ, Wang W, Renzi S, Seery V, Lee MY, Atkins MB: Impact of concomitant immunosuppression on the presentation and prognosis of patients with melanoma. Melanoma Res; 2010 Dec;20(6):496-500
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  • [Title] Impact of concomitant immunosuppression on the presentation and prognosis of patients with melanoma.
  • Melanoma has been reported to be susceptible to immune control, although the degree of impact of immunosuppression on the course of this disease is uncertain.
  • The Beth Israel Deaconess Medical Center's Cutaneous Oncology Program database was examined to identify patients receiving immunosuppressive therapy at the time of melanoma diagnosis.
  • Nineteen patients were identified with melanoma and concomitant immunosuppression in a database of 1839 patients.
  • Compared with the remaining database, patients on immunosuppression were more likely to be women (84 vs. 44%) with an amelanotic primary melanoma (21 vs. 5.3%).
  • Patients with immunosuppression were equally likely to relapse, but more likely to have died of melanoma than controls (42 vs. 23%) (P=0.01, log-rank test).
  • These findings suggest that immunosuppressive therapy is associated with a more aggressive disease course in patients with melanoma.
  • The additional observation that the stage-specific recurrence rates were similar, however, suggests that routine dermatologic screening of immunosuppressed patients may lead to earlier diagnosis and improved outcomes.
  • [MeSH-major] Immunosuppressive Agents / administration & dosage. Melanoma / immunology. Skin Neoplasms / immunology

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  • (PMID = 20823779.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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18. Camerin M, Rello S, Villanueva A, Ping X, Kenney ME, Rodgers MA, Jori G: Photothermal sensitisation as a novel therapeutic approach for tumours: studies at the cellular and animal level. Eur J Cancer; 2005 May;41(8):1203-12
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  • Irradiation of B78H1 murine amelanotic melanoma cells with 850 nm light emitted from a Ti:sapphire laser, operated in a pulsed mode at high fluence rates and in the presence of Ni(II)-octabutoxy-naphthalocyanine (NiNc), promoted a photothermally sensitised process leading to fast and irreversible cell death.
  • Very similar results were obtained upon irradiation of NiNc-loaded C32 human amelanotic melanoma cells and transformed murine HT-1080 and HaCaT fibroblasts.
  • From these results, photothermal sensitisation appears to be a general phenomenon and preliminary studies with mice bearing subcutaneously transplanted amelanotic melanomas, irradiated with 850 nm light 24 h after intravenous injection of NiNc, suggest that this approach has potential for the therapy of some types of skin tumours.
  • [MeSH-major] Melanoma, Amelanotic / drug therapy. Metalloporphyrins / therapeutic use. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use

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  • (PMID = 15911245.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 91027
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Metalloporphyrins; 0 / Photosensitizing Agents; 0 / octabutoxynaphthalocyaninenickel(II)
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19. Seya T, Tanaka N, Shinji S, Shinji E, Yokoi K, Horiba K, Kanazawa Y, Yamada T, Oaki Y, Tajiri T: Case of rectal malignant melanoma showing immunohistochemical variability in a tumor. J Nippon Med Sch; 2007 Oct;74(5):377-81
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  • [Title] Case of rectal malignant melanoma showing immunohistochemical variability in a tumor.
  • We report on a patient with rectal malignant melanoma.
  • With the diagnosis of neuroendocrine carcinoma of the rectum, abdominoperineal resection was performed.
  • However, the final pathological diagnosis of the surgically resected specimen was malignant amelanotic melanoma of the rectum.
  • As preoperative pathological diagnosis showed rare rectal tumor, we measured the chemosensitivity of the rectal tumor using the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) to determine the most appropriate chemotherapy regimen for the patient.
  • However, there were no anticancer drugs tested by CD-DST for malignant melanoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Melanoma / diagnosis. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Antigens, Neoplasm. Antineoplastic Combined Chemotherapy Protocols / pharmacology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Digestive System Surgical Procedures. Drug Resistance, Neoplasm. Drug Screening Assays, Antitumor / methods. Fatal Outcome. Humans. Immunohistochemistry. Interferon-beta / administration & dosage. Male. Melanoma-Specific Antigens. Neoadjuvant Therapy. Tumor Cells, Cultured

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  • (PMID = 17965534.001).
  • [ISSN] 1345-4676
  • [Journal-full-title] Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
  • [ISO-abbreviation] J Nippon Med Sch
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 77238-31-4 / Interferon-beta; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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20. Camerin M, Rodgers MA, Kenney ME, Jori G: Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity. Photochem Photobiol Sci; 2005 Mar;4(3):251-3
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  • Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation.
  • [MeSH-minor] Air. Animals. Cell Line, Tumor. Lasers. Melanoma, Experimental / drug therapy. Metalloporphyrins / therapeutic use. Mice. Nitrogen. Time Factors

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  • (PMID = 15738991.001).
  • [ISSN] 1474-905X
  • [Journal-full-title] Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • [ISO-abbreviation] Photochem. Photobiol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Metalloporphyrins; 0 / octabutoxynaphthalocyaninenickel(II); N762921K75 / Nitrogen
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21. Ferrari A, Bono A, Baldi M, Collini P, Casanova M, Pennacchioli E, Terenziani M, Marcon I, Santinami M, Bartoli C: Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution. Pediatrics; 2005 Mar;115(3):649-54
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  • [Title] Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution.
  • OBJECTIVE: To ascertain whether childhood melanoma presents any peculiar clinical features or differences in prognosis with respect to adults, we retrospectively analyzed the data from 33 patients who were up to 14 years of age and treated for cutaneous melanoma at the Istituto Nazionale Tumori, Milan, over a 25-year period.
  • METHODS: Primary lesions were amelanotic in half of the cases and raised in 73%.
  • Nine children had nodal involvement at diagnosis, 2 in-transit metastases, and 1 distant spread.
  • CONCLUSION: By comparison with adult cases, childhood melanoma can have a higher percentage of atypical clinical features (amelanotic and raised lesions), nodular histotype, and thick lesions.
  • Although we have no data to support any suggestion of biological differences between young children and adolescents or adults, our findings give the impression that melanoma behaves differently in the younger age group.
  • [MeSH-major] Melanoma. Skin Neoplasms

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  • [CommentIn] Pediatrics. 2005 Mar;115(3):802-3 [15741391.001]
  • (PMID = 15741367.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Kurotaki T, Tomonari Y, Kanno T, Wako Y, Tsuchitani M: Malignant amelanotic melanoma behind the left eye in a female Crj:CD(SD)IGS rat: a case report. Vet Pathol; 2008 Sep;45(5):681-4
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  • [Title] Malignant amelanotic melanoma behind the left eye in a female Crj:CD(SD)IGS rat: a case report.
  • It consisted of various tumor cells; namely, spindle-shaped, epithelioid, anaplastic melanoma cells, and had prominent eosinophilic cytoplasm and nuclei with a greater variation in size.
  • This is the first report describing an amelanotic melanoma in the head of an albino rat.
  • [MeSH-major] Bone Neoplasms / veterinary. Eye Neoplasms / veterinary. Melanoma, Amelanotic / veterinary. Rodent Diseases / pathology

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  • (PMID = 18725473.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Vad NM, Kandala PK, Srivastava SK, Moridani MY: Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach. Chem Biol Interact; 2010 Feb 12;183(3):462-71
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  • [Title] Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach.
  • The aim of this study was to identify a phenolic prodrug compound that is minimally metabolized by rat liver microsomes, but yet could form quinone reactive intermediates in melanoma cells as a result of its bioactivation by tyrosinase.
  • In current work, we investigated 24 phenolic compounds for their metabolism by tyrosinase, rat liver microsomes and their toxicity towards murine B16-F0 and human SK-MEL-28 melanoma cells.
  • A linear correlation was found between toxicities of phenolic analogs towards SK-MEL-28 and B16-F0 melanoma cells, suggesting similar mechanisms of toxicity in both cell lines.
  • 4-HEB (IC(50) 48h, 75muM) showed selective toxicity towards five melanocytic melanoma cell lines SK-MEL-28, SK-MEL-5, MeWo, B16-F0 and B16-F10, which express functional tyrosinase, compared to four non-melanoma cells lines SW-620, Saos-2, PC3 and BJ cells and two amelanotic SK-MEL-24, C32 cells, which do not express functional tyrosinase.
  • Our findings suggest that presence of a phenolic group in 4-HEB is critical for its selective toxicity towards melanoma cells.

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  • [Copyright] Published by Elsevier Ireland Ltd.
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  • (PMID = 19944085.001).
  • [ISSN] 1872-7786
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R15 CA122044; United States / NCI NIH HHS / CA / R15 CA122044-01A1; United States / NCI NIH HHS / CA / 1R15CA122044-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Phenols; 0 / Prodrugs; 0 / Reactive Oxygen Species; EC 1.14.18.1 / Monophenol Monooxygenase; GAN16C9B8O / Glutathione
  • [Other-IDs] NLM/ NIHMS167020; NLM/ PMC2821678
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24. Jeong TJ, Lee EJ, Haw S, Shin MK, Haw CR: Coexistence of amelanotic melanoma and liposarcoma. Ann Dermatol; 2009 Nov;21(4):409-12
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  • [Title] Coexistence of amelanotic melanoma and liposarcoma.
  • An amelanotic malignant melanoma is characterized by little or no pigment.
  • We encountered a case of amelanotic melanoma with a concurrent liposarcoma.
  • These findings were consistent with amelanotic melanoma.
  • However, an association between melanoma and liposarcoma is rare.

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  • (PMID = 20523835.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2861252
  • [Keywords] NOTNLM ; Amelanotic melanoma / Liposarcoma
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25. An J, Li B, Wu L, Lu H, Li N: Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res; 2009 Aug;19(4):267-70
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  • [Title] Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature.
  • Primary amelanotic melanoma of the female genital tract usually has a poor outcome as a consequence of delayed diagnosis and lack of standardized treatment.
  • Compared with amelanotic melanoma of the female genital tract of the vulva, disease of the cervix is more likely to be misdiagnosed, identified at a later stage, and have a poorer outcome.
  • [MeSH-major] Melanoma, Amelanotic. Uterine Cervical Neoplasms. Vulvar Neoplasms


26. McGregor DH, Cherian R, Romanas MM, Ulusarac O, Mathur SC, Feldman MM: Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma. Ann Clin Lab Sci; 2008;38(2):157-62
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  • [Title] Amelanotic malignant melanoma: two collision tumors presenting as basal cell carcinoma and atypical fibroxanthoma.
  • Collision (contiguous) tumors of the skin can result in misleading clinicopathological presentations, and the choice of appropriate diagnostic techniques may prevent incomplete diagnosis and management.
  • We report 2 cases of collision tumors involving amelanotic malignant melanoma of the back.
  • Subsequent excision showed that the lesion was largely composed of amelanotic melanoma underlying a relatively small and thin basal cell carcinoma, and this probably would have been demonstrated in a punch (rather than shave) biopsy.
  • The other patient is a 71-yr-old male with a 1 cm exophytic lesion on the back, which was determined microscopically to be melanoma, and a 0.6 cm papule on the back.
  • This lesion was composed of 2 distinct contiguous neoplastic infiltrates, the predominant component being an atypical fibroxanthoma and the smaller component an amelanotic melanoma (primary vs metastatic), with diagnostic confirmation requiring multiple immunohistochemical stains.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Histiocytoma, Benign Fibrous / diagnosis. Melanoma, Amelanotic / diagnosis. Neoplasms, Multiple Primary / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antigens, Neoplasm / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 18469362.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor
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27. Inoue T, Misago N, Narisawa Y: Metastatic myxoid melanoma with partial regression of the primary lesion. J Cutan Pathol; 2007 Jun;34(6):508-12
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  • [Title] Metastatic myxoid melanoma with partial regression of the primary lesion.
  • Myxoid melanoma is a rare variant of malignant melanoma.
  • The diagnostic problems are obviously increased when it presents as amelanotic metastasis in a lymph node.
  • In the pigmented lesion of the right forearm, there were small clusters of tumor cells with melanin granules, suggesting malignant melanoma.
  • In the present case, myxoid metastasis occurred with the partial spontaneous disappearance of the primary nonmyxoid malignant melanoma.
  • [MeSH-major] Melanoma / secondary. Mucus / metabolism. Neoplasm Regression, Spontaneous. Skin Neoplasms / pathology

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  • (PMID = 17518782.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Melanins
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28. Kranzfelder M, Seidl S, Dobritz M, Brücher BL: Amelanotic esophageal malignant melanoma: case report and short review of the literature. Case Rep Gastroenterol; 2008;2(2):224-31
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  • [Title] Amelanotic esophageal malignant melanoma: case report and short review of the literature.
  • Malignant melanoma in the esophagus is a rare condition which has been described only occasionally in case reports or in larger series of patients with esophageal disease.
  • We describe here the very rare case of a patient who presented initially with a 2-month history of dysphagia and weight loss which led to the endoscopic diagnosis of an unclear lesion in the distal esophagus.
  • As there were no signs of skin melanoma and there was an absence of pigmentation, a diagnosis of primary amelanotic malignant melanoma was made.
  • At the end of May 2007, 4 months after the primary diagnosis, the patient died due to acute renal failure.

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  • (PMID = 21327177.001).
  • [ISSN] 1662-0631
  • [Journal-full-title] Case reports in gastroenterology
  • [ISO-abbreviation] Case Rep Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3037985
  • [Keywords] NOTNLM ; Esophageal cancer / FDG-PET / Malignant melanoma
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29. Chun JK, Singer E, Kong A, Phelps R, Weltz C: Desmoplastic amelanotic melanoma in an irradiated burn scar. Dermatol Surg; 2006 Jan;32(1):161-4
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  • [Title] Desmoplastic amelanotic melanoma in an irradiated burn scar.
  • [MeSH-major] Burns / complications. Cicatrix / complications. Cicatrix / radiotherapy. Melanoma, Amelanotic / etiology. Skin Neoplasms / etiology

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  • (PMID = 16393619.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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30. Tundis R, Loizzo MR, Bonesi M, Menichini F, Dodaro D, Passalacqua NG, Statti G, Menichini F: In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines. Nat Prod Res; 2009;23(18):1707-18
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  • This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianus Lacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, amelanotic melanoma C32 and human breast adenocarcinoma MCF-7 cell lines.

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  • (PMID = 19921589.001).
  • [ISSN] 1478-6427
  • [Journal-full-title] Natural product research
  • [ISO-abbreviation] Nat. Prod. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Hexanes; 0 / Monoterpenes; 0 / Plant Extracts; 0 / Pyrrolizidine Alkaloids; 0 / Sesquiterpenes; 2DDG612ED8 / n-hexane; 54W56MD2WD / humulene; BHW853AU9H / caryophyllene; D81QY6I88E / linalool
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31. Collins JD: A man with pain and a large nevus on his thigh. J Natl Med Assoc; 2010 Jul;102(7):647-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Bone Neoplasms / diagnosis. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Diagnosis, Differential. Fever / etiology. Humans. Male. Pain / etiology. Weight Loss

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  • (PMID = 20690329.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Altamura D, Piccolo D, Lozzi GP, Peris K: Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma. J Am Acad Dermatol; 2005 Sep;53(3):539-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma.
  • [MeSH-major] Acrospiroma / diagnosis. Dermoscopy. Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16112378.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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33. Klopper JP, Sharma V, Bissonnette R, Haugen BR: Combination PPARgamma and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2. PPAR Res; 2010;2010:729876
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combination PPARgamma and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2.
  • Nuclear hormone receptors, including RXR and PPARgamma, represent novel therapeutic targets in melanoma.
  • We have previously shown that the DRO subline of the amelanotic melanoma A375 responds to rexinoid and thiazolidinedione (TZD) treatment in vitro and in vivo.
  • In summary, we have identified potential downstream mediators of rexinoid and TZD treatment in a poorly differentiated melanoma and found that alterations in S100A2 expression affect RXR and PPARgamma signaling in A375(DRO) cells.

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  • (PMID = 19859558.001).
  • [ISSN] 1687-4765
  • [Journal-full-title] PPAR research
  • [ISO-abbreviation] PPAR Res
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA100560
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2763133
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34. Nalamwar R, Kharkar V, Mahajan S, Chikhalkar S, Khopkar U: Nodular amelanotic melanoma. Indian J Dermatol Venereol Leprol; 2010 May-Jun;76(3):273-5
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  • [Title] Nodular amelanotic melanoma.
  • Malignant cells were positive for S100 and human melanin black 45(HMB 45).
  • Hence, a diagnosis of amelanotic melanoma (AM)--Clarke level IV and TNM stage III was reached.
  • Fine needle aspiration cytology (FNAC) from the right inguinal nodes confirmed metastasis of melanoma.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery

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  • (PMID = 20445300.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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35. Wang S, Thamboo TP, Nga ME, Zin T, Cheng A, Tan KB: C-kit positive amelanotic melanoma of the oesophagus: a potential diagnostic pitfall. Pathology; 2008 Aug;40(5):527-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] C-kit positive amelanotic melanoma of the oesophagus: a potential diagnostic pitfall.
  • [MeSH-major] Esophageal Neoplasms / metabolism. Esophageal Neoplasms / pathology. Melanoma, Amelanotic / metabolism. Proto-Oncogene Proteins c-kit / biosynthesis
  • [MeSH-minor] Aged, 80 and over. Diabetes Mellitus / pathology. Diagnosis, Differential. Female. Gastrointestinal Stromal Tumors / pathology. Humans. Hypertension / complications. Immunohistochemistry

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  • (PMID = 18604743.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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36. Kusick S, Bertram H, Oberleithner H, Ludwig T: Nanoscale imaging and quantification of local proteolytic activity. J Cell Physiol; 2005 Sep;204(3):767-74
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  • Malignant cells secrete most proteases as inactive proenzymes that undergo proteolytic cleavage for activation, and proteolytic activity is elevated in close proximity to these cells.
  • Amelanotic melanoma cells (A7-clone) were seeded on fluorescent gelatin or collagen-IV coatings.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15744770.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins; EC 3.4.- / Peptide Hydrolases
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37. Morita N, Hiratsuka J, Kondoh H, Uno M, Asano T, Niki Y, Sakurai Y, Ono K, Harada T, Imajo Y: Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene. Cancer Res; 2006 Apr 1;66(7):3747-53
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  • [Title] Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
  • In melanoma, (10)B-para-boronophenylalanine (BPA) accumulation is proportional to melanin-producing activity.
  • This study was done to confirm enhancement of the tumor-suppressive effect of BNCT on amelanotic melanoma by intratumoral injection of the tyrosinase gene.
  • D178 or FF amelanotic melanomas were implanted s.c. in Syrian hamsters.
  • In vivo transfection with the tyrosinase gene increased BPA accumulation in the tumors, the BNCT tumor-suppressive effect on amelanotic melanoma being significantly enhanced.
  • These findings suggest a potential new clinical strategy for the treatment of amelanotic melanoma with BNCT.
  • [MeSH-major] Boron Neutron Capture Therapy / methods. Genetic Therapy / methods. Melanoma, Amelanotic / enzymology. Melanoma, Amelanotic / radiotherapy. Monophenol Monooxygenase / genetics. Skin Neoplasms / enzymology. Skin Neoplasms / radiotherapy

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  • (PMID = 16585201.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Boron Compounds; 0 / Radiation-Sensitizing Agents; 47E5O17Y3R / Phenylalanine; EC 1.14.18.1 / Monophenol Monooxygenase; UID84303EL / 4-boronophenylalanine
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38. Jain V, Dabir S, Shome D, Dadu T, Natarajan S: Aspergillus iris granuloma: a case report with review of literature. Surv Ophthalmol; 2009 Mar-Apr;54(2):286-91
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  • Differential diagnoses of a fungal granuloma, a medulloepithelioma, and an amelanotic melanoma were considered.
  • Definitive differentiation of this rare entity from a foreign body, amelanotic melanoma, and other inflammatory conditions such as sarcoidosis and tuberculosis, may be possible only on microbiological and histo-pathological evaluation.

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  • (PMID = 19298905.001).
  • [ISSN] 0039-6257
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Aza Compounds; 0 / DNA, Fungal; 0 / Fluoroquinolones; 0 / Quinolines; 7C0697DR9I / Atropine; 8O0C852CPO / Natamycin; U188XYD42P / moxifloxacin
  • [Number-of-references] 18
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39. Conforti F, Ioele G, Statti GA, Marrelli M, Ragno G, Menichini F: Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem Toxicol; 2008 Oct;46(10):3325-32
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  • Sixteen edible plants from Southern Italy were evaluated for their in vitro antiproliferative properties, using the sulforodamine B (SRB) assay, on four human cancer cell lines: breast cancer MCF-7, prostate cancer LNCaP, amelanotic melanoma C32 and renal adenocarcinoma ACHN.
  • Mentha aquatica showed a selective antiproliferative activity on breast cancer while significant activity was exerted by Cichorium intybus on melanoma.

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  • (PMID = 18768152.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Plant Extracts
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40. Blum A: [Therapy of amelanotic melanoma]. Dtsch Med Wochenschr; 2005 May 20;130(20):1277
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapy of amelanotic melanoma].
  • [MeSH-major] Melanoma, Amelanotic / therapy. Skin Neoplasms / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Sentinel Lymph Node Biopsy. Skin / pathology. Time Factors

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  • (PMID = 15889328.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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41. Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G: How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. J Am Acad Dermatol; 2010 Sep;63(3):377-86; quiz 387-8
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  • [Title] How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors.
  • Nonmelanoma skin cancer refers to a broad class of tumors, including actinic keratosis, basal cell carcinoma, and squamous cell carcinoma, and as a group these are the most frequent cancers occurring in light skinned humans.
  • In contrast to the rarity of amelanotic melanoma, nonmelanoma skin cancer commonly lacks pigmentation.
  • Dermoscopy improves the clinical diagnosis of nonpigmented skin tumors by allowing the visualization of specific vascular structures that are usually not visible to the naked eye.
  • Dermoscopic vascular patterns of several nonmelanocytic nonpigmented skin tumors, such as sebaceous hyperplasia, seborrheic keratosis, clear cell acanthoma, Bowen disease, or nodular cystic basal cell carcinoma are highly specific, allowing a ready diagnosis in most cases.
  • In the second part of this review of dermoscopic vascular structures of nonpigmented skin tumors, the dermoscopic patterns associated with benign and malignant nonmelanocytic skin tumors and recommendations for the management of these tumors will be discussed.
  • [MeSH-major] Dermoscopy / methods. Skin / blood supply. Skin Neoplasms / blood supply. Skin Neoplasms / diagnosis
  • [MeSH-minor] Blood Vessels / pathology. Bowen's Disease / blood supply. Bowen's Disease / diagnosis. Bowen's Disease / pathology. Carcinoma, Basal Cell / blood supply. Carcinoma, Basal Cell / diagnosis. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Education, Medical, Continuing. Female. Humans. Keratosis, Seborrheic / diagnosis. Keratosis, Seborrheic / pathology. Male. Melanoma, Amelanotic / blood supply. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology


42. Jasaitiene D, Valiukeviciene S, Makstiene J, Juodzbaliene EB: Metastatic amelanotic nodular melanoma during pregnancy. Medicina (Kaunas); 2008;44(6):467-71
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  • [Title] Metastatic amelanotic nodular melanoma during pregnancy.
  • This case report presents a very aggressive course of amelanotic nodular melanoma during pregnancy resulting in death five months after delivery.
  • A 34 year-old Caucasian woman at 19th week of the second pregnancy was diagnosed having amelanotic nodular melanoma (tumor thickness - 2.5 mm) with metastases to the regional right inguinal lymph node.
  • Amelanotic nodular melanoma represents malignant melanocytic tumor of the skin, which clinically mimics a variety of benign and malignant skin conditions and therefore commonly leads to delayed diagnosis.
  • Since pregnancy limits the prescription of immunotherapy and chemotherapy, the prognosis for melanoma during pregnancy detected later than in the second stage is poor and can be illustrated by our reported case.
  • Such patients seems to be at higher risk to develop metastasis of melanoma in the internal organs and occasionally even in the fetus; therefore, they should be timely informed about that.
  • [MeSH-major] Melanoma, Amelanotic / secondary. Pregnancy Complications, Neoplastic. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Female. Humans. Immunohistochemistry. Infant, Newborn. Lymph Node Excision. Lymphatic Metastasis. Pregnancy. Pregnancy Trimester, Second. Pregnancy Trimester, Third. Prognosis. Puerperal Disorders / mortality. Skin / pathology. Time Factors


43. Hargis AM, Baldessari AE, Walder EJ: Intraepidermal adenocarcinoma in the perianal skin of two cats, a condition resembling human extramammary Paget's disease. Vet Dermatol; 2008 Feb;19(1):31-7
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  • [Title] Intraepidermal adenocarcinoma in the perianal skin of two cats, a condition resembling human extramammary Paget's disease.
  • This report describes two cats with lesions in perianal skin consisting of atypical intraepidermal neoplastic cells.
  • Differential diagnoses included intraepidermal adenocarcinoma, in situ squamous or basal cell carcinoma, junctional amelanotic melanoma, and epitheliotropic tumours of histiocytic or lymphocytic origin.
  • The clinical features, histological appearance, and immunohistochemical staining of the skin lesions were consistent with those described for human perianal extramammary Paget's disease.
  • [MeSH-major] Adenocarcinoma / veterinary. Cat Diseases / diagnosis. Perineum / pathology. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Diagnosis, Differential. Female. Humans. Paget Disease, Extramammary

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  • (PMID = 18177290.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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44. Zamberk-Majlis P, Velázquez-Tarjuelo D, Avilés-Izquierdo JA, Lázaro-Ochaita P: [Dermoscopic characterization of 3 cases of fibroepithelioma of Pinkus]. Actas Dermosifiliogr; 2009 Dec;100(10):899-902
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  • [Transliterated title] Fibroepitelioma de Pinkus. Descripción dermatoscópica de 3 casos.
  • Clinical diagnosis often requires differentiation from benign lesions such as acrochordon, intradermal melanocytic nevus, neurofibroma, seborrheic keratosis, and even malignant lesions such as amelanotic melanoma.
  • Dermoscopy of this type of lesion is not extensively described in the literature, though it usually presents certain specific characteristics that suggest the diagnosis and, therefore, an appropriate therapeutic approach.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy. Skin Neoplasms / pathology

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  • (PMID = 20038369.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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45. Betti R, Menni S, Crosti C: A reddish nodule on the glans penis--quiz case. Arch Dermatol; 2006 Apr;142(4):515-20
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  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Metastasis. Penis / pathology

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  • (PMID = 16618877.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Yhee JY, Hong SW, Yu CH, Doster AR, Blas-Machado U, Lyoo YS, Sur JH: Immunohistochemical application of an antibody specific for human CD1a to the diagnosis of canine mast cell tumour. J Comp Pathol; 2008 Jul;139(1):40-6
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  • [Title] Immunohistochemical application of an antibody specific for human CD1a to the diagnosis of canine mast cell tumour.
  • This antibody did not label neoplastic cells in cases of canine histiocytoma, plasmacytoma or amelanotic melanoma; therefore, the reagent may be a valuable marker for the diagnosis of canine MCTs, especially those tumours of histological grade III.
  • [MeSH-major] Antibodies, Monoclonal. Antigens, CD1 / immunology. Dog Diseases / diagnosis. Mastocytosis / veterinary. Skin Neoplasms / veterinary

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  • (PMID = 18602642.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD1; 0 / CD1a antigen
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47. Yanagi T, Akiyama M, Kasai M, Yamakura M, Nishio M, Shimizu H: Multiple skin metastases of amelanotic melanoma originating from the sinonasal mucosa. Acta Derm Venereol; 2005;85(6):554-5
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  • [Title] Multiple skin metastases of amelanotic melanoma originating from the sinonasal mucosa.
  • [MeSH-major] Maxillary Sinus Neoplasms / pathology. Melanoma, Amelanotic / secondary. Skin Neoplasms / secondary

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  • (PMID = 16396817.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
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48. Ladoyanni E, Abdullah A, Sterne GD, Zaki I: Amelanotic melanoma--"to be or not to be". Acta Derm Venereol; 2006;86(2):189-90
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  • [Title] Amelanotic melanoma--"to be or not to be".
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 16648938.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
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49. Dainichi T, Kobayashi C, Fujita S, Shiramizu K, Ishiko T, Kiryu H, Urabe K, Tsuneyoshi M, Furue M: Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis. J Dermatol; 2007 Oct;34(10):716-9
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  • [Title] Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis.
  • Herein, we report a rare case of amelanotic spindle-cell melanoma on the interdigit of the left fifth toe of an 83-year-old woman.
  • Two biopsies could not lead us to the correct diagnosis until the totally excised specimen was evaluated with immunohistochemical analysis including S-100 and other melanocyte markers.
  • This case suggests that refractory interdigital dermatophytoses should be treated by considering the possibility of concomitant malignant neoplasms, and immunohistochemical analysis is indispensable for differential diagnosis of malignant neoplasms suggesting nonspecific granulation.
  • [MeSH-major] Dermatomycoses / diagnosis. Foot Diseases / diagnosis. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Antigens, Neoplasm. Diagnosis, Differential. Fatal Outcome. Female. Humans. Immunohistochemistry. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. S100 Proteins / analysis

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  • (PMID = 17908146.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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50. Dickinson RM, Young KM: Cutaneous mass aspirate from a Golden Retriever: "glandular guile". Vet Clin Pathol; 2005 Dec;34(4):421-4
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  • On cytologic evaluation of a fine-needle aspirate of the mass, the interpretation was a malignant tumor with predominantly mesenchymal features.
  • Differentials included liposarcoma, atypical amelanotic melanoma, anaplastic sarcoma, and anaplastic carcinoma.
  • Following complete excision of the mass, a diagnosis of sebaceous adenocarcinoma was made based on histologic features, positive immunostaining for pancytokeratin, and negative staining for vimentin, Melan-A, and S-100.

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  • (PMID = 16270273.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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51. Mandato VD, Kobal B, Di Stefano A, Sinkovec J, Levicnik A, Rakar S, Costagliola L: Amelanotic malignant melanoma of the uterine cervix with ten-year follow-up. Eur J Gynaecol Oncol; 2009;30(1):106-9
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  • [Title] Amelanotic malignant melanoma of the uterine cervix with ten-year follow-up.
  • BACKGROUND: Malignant melanoma (MM) accounts for 3% of cancers that affect women and results in less than 1% of cancer deaths.
  • Fewer than ten cases of amelanotic MM (AMM) have been reported in literature.
  • CONCLUSION: Malignant melanoma of the cervix is often misdiagnosed because of non discriminatory features and the capacity to mimic other tumors.
  • Malignant melanoma of the cervix needs to be diagnosed as quickly as possible because a timely therapy and a long and careful follow-up might result in better survival.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology. Uterine Cervical Neoplasms / pathology


52. Lee SH, Hong JS, Choi JH, Chung WS: Choroidal schwannoma. Acta Ophthalmol Scand; 2005 Dec;83(6):754-6
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  • CONCLUSIONS: We enucleated the eyeball with a clinical diagnosis of choroidal amelanotic melanoma, but the tumor was finally diagnosed as schwannoma.
  • [MeSH-minor] Aged. Diagnosis, Differential. Eye Enucleation. Female. Humans. Magnetic Resonance Imaging. Visual Acuity

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  • (PMID = 16396657.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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53. Conforti F, Menichini F, Rigano D, Senatore F: Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes. Z Naturforsch C; 2009 Jul-Aug;64(7-8):490-4
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  • The in vitro cytotoxic activity assay against two human cancer cell lines, large lung carcinoma (CORL-23) and amelanotic melanoma (C32), showed that the most antiproliferative extract was the MeOH extract from flowers with a percentage of inhibition of 50.9 at 100 microg/ml against amelanotic melanoma cells.
  • The most antiproliferative compounds against amelanotic melanoma cells were kaempferol-3-O-beta-D-glucopyranoside and irisolidone with a percentage of inhibition of 100 and 96.6, respectively, and against large lung carcinoma cells with a percentage of inhibition of 82.1 and 84.6, respectively.
  • Significant activity on the amelanotic melanoma cell line was also showed by irigenin-7-O-beta-D-glucopyranoside, with a percentage of inhibition of 89.3.
  • The compounds isovitexin and isoorientin-6-O''-beta-D-glucopyranoside showed a selective activity against amelanotic melanoma cells with a percentage of inhibition of 83.2 and 79.8, respectively.
  • [MeSH-minor] Carcinoma, Large Cell / pathology. Cell Line, Tumor. Humans. Lung Neoplasms / pathology. Melanoma, Amelanotic / pathology. Plant Extracts / chemistry. Polyphenols

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  • (PMID = 19791498.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Flavonoids; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols
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54. Peterson J, Rowley M: Rhinophymatous amelanotic melanoma. Cutis; 2007 May;79(5):383-6
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  • [Title] Rhinophymatous amelanotic melanoma.
  • Amelanotic melanomas are well-known to mimic other dermatologic lesions and often result in delayed diagnosis and treatment.
  • We report a case of an unusual presentation of amelanotic melanoma with an appearance similar to rhinophyma.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Nose / pathology. Rhinoplasty. Surgical Flaps

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  • (PMID = 17569401.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Latendresse JR, Muskhelishvili L, Warbritton A, Tolleson WH: Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice. Toxicol Pathol; 2007 Oct;35(6):827-32
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  • [Title] Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice.
  • Uveal melanoma (UM) is uncommon among wild type mice.
  • Reported here are two early stage intraocular amelanotic melanomas discovered in 2 Tyr-HRAS+ Ink4a/Arf heterozygous (1 normal CKDN2A allele) transgenic FVB/n mice.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Disease Models, Animal. Genes, ras. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / genetics. Uveal Neoplasms / pathology

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  • (PMID = 17987514.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; EC 1.14.18.1 / Monophenol Monooxygenase
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56. Donaldson MJ, Lim L, Harper CA, Mackenzie J, G Campbell W: Primary treatment of choroidal amelanotic melanoma with photodynamic therapy. Clin Exp Ophthalmol; 2005 Oct;33(5):548-9
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  • [Title] Primary treatment of choroidal amelanotic melanoma with photodynamic therapy.
  • The management of choroidal melanoma involves a delicate balance between preserving vision and preventing metastasis.
  • Transpupillary thermotherapy avoids these side-effects; however, it can also result in visual loss and its effectiveness is limited in amelanotic lesions.
  • Photodynamic therapy with verteporfin has shown promise in animal studies of choroidal melanoma, and has recently been used in the management of lesions that have failed to respond to conventional therapy.
  • The authors report a case of primary treatment of a small choroidal amelanotic melanoma with photodynamic therapy using verteporfin.
  • [MeSH-major] Choroid Neoplasms / drug therapy. Melanoma, Amelanotic / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use. Porphyrins / therapeutic use

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  • [CommentIn] Clin Exp Ophthalmol. 2006 Sep-Oct;34(7):721; author reply 721-2 [16970777.001]
  • (PMID = 16181294.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 129497-78-5 / verteporfin
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57. Lorentzen HF, Weismann K, Rossen K, Klem Thomsen H: Poppyfield bleeding: a new dermatoscopic sign and its histopathological background. Acta Derm Venereol; 2007;87(2):149-51
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  • Dermatoscopy increases the accuracy of diagnosis of melanoma.
  • An atypical vascular pattern may be an indicator of cutaneous malignant melanoma (CMM).
  • Age of the patients and Breslow thickness of the cutaneous malignant melanoma were similar in the two groups.
  • It may be a dermatoscopic reflection of increased vascular density described in primary CMMs compared with adjacent skin and may also reflect the presence of primitive vessels in CMMs displaying increased fragility.
  • [MeSH-major] Dermoscopy / methods. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Humans. Melanoma, Amelanotic / blood supply. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology

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  • (PMID = 17340022.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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58. Ren G, Miao Z, Liu H, Jiang L, Limpa-Amara N, Mahmood A, Gambhir SS, Cheng Z: Melanin-targeted preclinical PET imaging of melanoma metastasis. J Nucl Med; 2009 Oct;50(10):1692-9
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  • [Title] Melanin-targeted preclinical PET imaging of melanoma metastasis.
  • Dialkylamino-alkyl-benzamides possess an affinity for melanin, suggesting that labeling of such benzamides with (18)F could potentially produce melanin-targeted PET probes able to identify melanotic melanoma metastases in vivo with high sensitivity and specificity.
  • In vivo distribution and small-animal PET studies were conducted on mice bearing B16F10 melanoma, A375M amelanotic melanoma, and U87MG tumors, and comparative studies were performed with (18)F-FDG PET in the melanoma models.
  • In vivo, (18)F-FBZA displayed significant tumor uptake; at 2 h, 5.94 +/- 1.83 percentage injected dose (%ID) per gram was observed in B16F10 tumors and only 0.75 +/- 0.09 %ID/g and 0.56 +/- 0.13 %ID/g was observed in amelanotic A375M and U87MG tumors, respectively.
  • CONCLUSION: (18)F-FBZA specifically targets primary and metastatic melanotic melanoma lesions with high tumor uptake and may have translational potential.

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  • (PMID = 19759116.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA114747; United States / NCI NIH HHS / CA / R24 CA93862
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzamides; 0 / Fluorine Radioisotopes; 0 / Melanins; 0 / Receptors, sigma
  • [Other-IDs] NLM/ NIHMS636087; NLM/ PMC4215196
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59. Godbole D, Mojamdar M, Pal JK: Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis. Cell Biol Int; 2006 Nov;30(11):895-902
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
  • Proteasomes have been shown to be involved in the regulation of melanin biosynthesis in melanoma cells.
  • Here we report on the correlation between proteasome subunits and Tyrosinase (Tyr) activity in different cell phenotypes, and thereby regulation of melanin biosynthesis in B16F10 mouse melanoma cells.
  • Our results indicated that the quantity of proteasome subunit p27 is higher and that of the enzyme Tyr and its activity are lower in amelanotic melanoma cells, while the reverse is true in melanotic melanoma cells.
  • Proteasome subunit p27, compared to another subunit p31, shows increased co-localization with Tyr and Tyrosinase related protein 1 (Trp1) in amelanotic cells to a greater extent than that in melanotic cells.
  • On exposure to cycloheximide, increased Tyr degradation was seen in amelanotic cells, as indicated by increased co-localization of p27 and Tyr.
  • Further, exposure of amelanotic melanoma cells with proteasome-specific inhibitor MG132 resulted in an increased Tyr activity, increased levels of Tyr and Trp1, leading to increased melanin synthesis.
  • These results therefore suggest that proteasomes, particularly p27 subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells.
  • [MeSH-major] Melanins / biosynthesis. Melanoma, Amelanotic / enzymology. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / metabolism. Proteasome Endopeptidase Complex / metabolism. Protein Subunits / metabolism

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  • (PMID = 16879986.001).
  • [ISSN] 1065-6995
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leupeptins; 0 / Melanins; 0 / Proteasome Inhibitors; 0 / Protein Subunits; 133407-82-6 / benzyloxycarbonylleucyl-leucyl-leucine aldehyde; 98600C0908 / Cycloheximide; EC 1.- / Oxidoreductases; EC 1.14.18.- / tyrosinase-related protein-1; EC 1.14.18.1 / Monophenol Monooxygenase; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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60. Valdes A, Kulekowskis AM, Curtis L: Case report: amelanotic melanoma located on the lower extremity. Am Fam Physician; 2007 Dec 1;76(11):1614, 1618
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report: amelanotic melanoma located on the lower extremity.
  • [MeSH-major] Foot. Melanoma, Amelanotic. Skin Neoplasms

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  • [CommentOn] Am Fam Physician. 2005 Jul 15;72(2):269-76 [16050450.001]
  • (PMID = 18092703.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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61. Loizzo MR, Tundis R, Menichini F, Saab AM, Statti GA, Menichini F: Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. Cell Prolif; 2008 Dec;41(6):1002-1012
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  • [Title] Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells.
  • Antiproliferative activity was tested on amelanotic melanoma C32 cells and on renal cell adenocarcinoma cells, using the sulphorhodamine B assay.
  • RESULTS: Cupressus sempervirens ssp. pyramidalis leaf oil exerted the highest cytotoxic activity with an IC(50)value of 104.90 microg/mL against C32, followed by activity of P. orientalis and P. asperula on the renal adenocarcinoma cell line (IC(50) of 121.93 and 139.17 microg/mL, respectively). P. orientalis essential oil was also active against amelanotic melanoma with an IC(50) of 330.04 microg/mL.
  • [MeSH-major] Carcinoma, Renal Cell / drug therapy. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / drug therapy. Melanoma, Amelanotic / drug therapy. Melanoma, Amelanotic / pathology. Oils, Volatile / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 19040575.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oils, Volatile; 0 / Plant Oils; 0 / Terpenes
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62. Rütten A: [Malignant melanoma in children and adolescents]. Pathologe; 2007 Nov;28(6):437-44
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  • [Title] [Malignant melanoma in children and adolescents].
  • According to data from the literature and to new data from the German central registry for malignant melanomas from the German Society of Dermatology, a summary is given about the occurrence of malignant melanoma in children and adolescents up to 18 years of age.
  • During the first 10 years of life the occurrence of a melanoma is extremely rare, but slowly increases after the first decade.
  • Several studies have shown that young people often have amelanotic tumors resembling pyogenic granuloma.
  • A reason might be a delay in the clinical diagnosis of malignant melanoma in children and young adults.
  • Clinical and histopathological examples of melanoma in young people are demonstrated.
  • Pitfalls in differential diagnosis and simulators of malignant melanoma are described and illustrated by examples of a medium sized congenital nevus with extensive intraepithelial spread of single melanocytes resembling a superficial spreading melanoma and by a compound nevus in association with a lichen sclerosus et atrophicus.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Child. Diagnosis, Differential. Foot Diseases / pathology. Germany / epidemiology. Humans. Incidence. Nevus, Pigmented / pathology. Registries

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  • (PMID = 17874108.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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63. Panasiti V, Devirgiliis V, Curzio M, Roberti V, Gobbi S, Masciangelo R, Mastrecchia B, Calvieri S, Bottoni U: The reticular point of view in dermatoscopy. J Am Acad Dermatol; 2009 Oct;61(4):605-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Different dermatoscopic algorithms have been developed to evaluate pigmented lesions of the skin, with pattern analysis being the most commonly used.
  • We sought to develop and evaluate a diagnostic scoring system, the reticular point of view, to distinguish common melanocytic nevus from dysplastic nevus and from melanoma.
  • Regarding the diagnosis of melanoma, only the presence of large holes, areas of abrupt cut off, and linear extensions revealed statistical significance.
  • It is not applicable in nodular, thick, and amelanotic melanomas that are usually lacking in pigment network.
  • CONCLUSION: Although pattern analysis represents the most effective analytical method in dermatoscopy, our scoring system may be useful to distinguish between benign lesions, which need only clinical follow-up, and malignant lesions, which need surgical excision.
  • [MeSH-major] Algorithms. Dermoscopy / methods. Dysplastic Nevus Syndrome / diagnosis. Melanoma / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. ROC Curve. Reproducibility of Results. Sensitivity and Specificity. Severity of Illness Index. Skin Pigmentation

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  • (PMID = 19703721.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Sbano P, Nami N, Grimaldi L, Rubegni P: True amelanotic melanoma: the great masquerader. J Plast Reconstr Aesthet Surg; 2010 Mar;63(3):e307-8
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  • [Title] True amelanotic melanoma: the great masquerader.
  • [MeSH-major] Dermoscopy. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19713163.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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65. Goodman G, Bercovich D: Melanin directly converts light for vertebrate metabolic use: heuristic thoughts on birds, Icarus and dark human skin. Med Hypotheses; 2008 Aug;71(2):190-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanin directly converts light for vertebrate metabolic use: heuristic thoughts on birds, Icarus and dark human skin.
  • Pigments serve many visually obvious animal functions (e.g. hair, skin, eyes, feathers, scales).
  • Clinicians and researchers are well acquainted with melanin in skin and ocular pathologies and now increasingly are with internal, melanized, pathology-associated sites not obviously subject to light radiation (e.g. brain, cochlea).
  • At both types of sites some findings puzzle: positive and negative neuromelanin effects in Parkinsons; unexpected melanocyte action in the cochlea, in deafness; melanin reduces DNA damage, but can promote melanoma; in melanotic cells, mitochondrial number was 83% less, respiration down 30%, but development similar to normal amelanotic cells.
  • [MeSH-major] Melanins / physiology. Skin / pathology
  • [MeSH-minor] Animals. Birds. Capillaries / metabolism. DNA Damage. Humans. Light. Melanocytes / metabolism. Melanoma / etiology. Microscopy, Electron, Scanning. Models, Biological. Retinal Vessels / anatomy & histology. Retinal Vessels / metabolism. Ultraviolet Rays. Vertebrates

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  • (PMID = 18479839.001).
  • [ISSN] 0306-9877
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Melanins
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66. Blum A, Metzler G, Bauer J: Polymorphous vascular patterns in dermoscopy as a sign of malignant skin tumors. A case of an amelanotic melanoma and a porocarcinoma. Dermatology; 2005;210(1):58-9
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  • [Title] Polymorphous vascular patterns in dermoscopy as a sign of malignant skin tumors. A case of an amelanotic melanoma and a porocarcinoma.
  • BACKGROUND: Using dermoscopy (dermatoscopy, epiluminescence microscopy), malignant skin tumors can be detected earlier and unnecessary excisions of benign tumors can be avoided.
  • OBJECTIVE: Description of the dermoscopic vascular patterns of an amelanotic melanoma and a porocarcinoma.
  • METHODS: Dermoscopy of an amelanotic melanoma and a porocarcinoma at 10-fold magnification.
  • CONCLUSION: A reddish tumor without any pigmented network, globules or streaks but with polymorphous vascular patterns must be considered a malignant melanocytic or nonmelanocytic skin tumor.
  • [MeSH-major] Melanoma / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Buttocks. Diagnosis, Differential. Female. Humans. Leg. Male. Microscopy / methods. Middle Aged

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  • (PMID = 15604548.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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67. Elizalde J, Ubia S, Barraquer RI: Adenoma of the nonpigmented ciliary epithelium. Eur J Ophthalmol; 2006 Jul-Aug;16(4):630-3
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  • Adenoma of the non pigmented ciliary epithelium may mimic an amelanotic melanoma.
  • Partial lamellar sclerouvectomy is an effective method to manage this condition and to confirm the diagnosis.

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  • (PMID = 16952109.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Wen YH, Giashuddin S, Shapiro RL, Velazquez E, Melamed J: Unusual occurrence of a melanoma with intermixed epithelial component: a true melanocarcinoma?: case report and review of epithelial differentiation in melanoma by light microscopy and immunohistochemistry. Am J Dermatopathol; 2007 Aug;29(4):395-9
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  • [Title] Unusual occurrence of a melanoma with intermixed epithelial component: a true melanocarcinoma?: case report and review of epithelial differentiation in melanoma by light microscopy and immunohistochemistry.
  • Histological examination showed a malignant nodular neoplasm with 2 distinct but intimately admixed components: a malignant melanoma with a spindle component and an unusual glandular component.
  • A single melanocytic marker (MITF) was expressed in both components, raising the possibility of dual differentiation in a single tumor, rather than the alternative considerations of a collision tumor or a reactive pseudoepitheliomatous hyperplasia with eccrine duct lumen formation within a melanoma.
  • This unusual tumor with both melanocytic and epithelial components may represent a true melanocarcinoma, which becomes a plausible consideration, in view of melanoma plasticity and recent experimental evidence and speculation about the role of stem cells in melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Neoplasms, Glandular and Epithelial / pathology. Neoplasms, Multiple Primary / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 17667176.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 68238-35-7 / Keratins
  • [Number-of-references] 41
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69. Mondin V, Rinaldo A, Shaha A, Cureoglu S, Devaney KO, Suárez C, Ferlito A: Malignant melanoma of the auricle. Acta Otolaryngol; 2005 Nov;125(11):1140-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant melanoma of the auricle.
  • Malignant melanomas are found in a variety of locations, ranging from sun-exposed skin to the nasal cavity and paranasal sinuses.
  • Melanomas of the external ear may present as flat pigmented lesions or as raised mass lesions; amelanotic (non-pigmented) variants exist as well.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear, External. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16353384.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 42
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70. Zand S, Lio PA, Mackool BT, Duncan LM: A slightly erythematous, firm papule on the upper arm--quiz case. Arch Dermatol; 2005 Jan;141(1):93-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Arm. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 15655153.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Pizzichetta MA, Canzonieri V, Massarut S, Baresic T, Borsatti E, Menzies SW: Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. J Am Acad Dermatol; 2010 May;62(5):893-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pitfalls in the dermoscopic diagnosis of amelanotic melanoma.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Necrosis

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  • [CommentOn] J Am Acad Dermatol. 2007 Mar;56(3):508-13 [17113189.001]
  • (PMID = 20398822.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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72. Dubrey S, Grocott-Mason R, Mittal T, Burke M: Massive cardiac invasion by amelanotic melanoma with obstructive clinical features. Postgrad Med J; 2008 Mar;84(989):163-6
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  • [Title] Massive cardiac invasion by amelanotic melanoma with obstructive clinical features.
  • Reports of malignant melanoma involving the heart usually describe metastatic spread of pigmented (melanotic) forms of this tumour.
  • The case is unusual in relation to the extreme size of this amelanotic melanoma at presentation and the fact that it appears to be a solitary metastasis.
  • [MeSH-major] Cardiac Tamponade / etiology. Heart Neoplasms / secondary. Melanoma, Amelanotic / secondary. Skin Neoplasms

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  • (PMID = 18372490.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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73. Liébana ES, González DJ, Martín M, Saiz A: Atypical presentation of cardiac metastasis of amelanotic melanoma. Int J Cardiovasc Imaging; 2009 Apr;25(4):343-4
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  • [Title] Atypical presentation of cardiac metastasis of amelanotic melanoma.
  • We present the case of a 67-year-old patient, asymptomatic, with a prior diagnosis of amelanotic cutaneous melanoma with positive ganglions (2002), who was referred for thoracic-abdominal-pelvic computed tomography (CT) as part of routine follow-up (2007).
  • [MeSH-major] Heart Neoplasms / diagnosis. Heart Neoplasms / secondary. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Contrast Media. Diagnosis, Differential. Gadolinium DTPA. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • [Cites] Radiographics. 2001 Mar-Apr;21(2):439-49 [11259706.001]
  • [Cites] Int J Cardiovasc Imaging. 2004 Dec;20(6):523-6; discussion 527-8 [15856636.001]
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  • (PMID = 19214775.001).
  • [ISSN] 1875-8312
  • [Journal-full-title] The international journal of cardiovascular imaging
  • [ISO-abbreviation] Int J Cardiovasc Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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74. Gosselink CP, Sindone JL, Meadows BJ, Mohammadi A, Rosa M: Amelanotic subungual melanoma: a case report. J Foot Ankle Surg; 2009 Mar-Apr;48(2):220-4
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  • [Title] Amelanotic subungual melanoma: a case report.
  • Subungual melanoma is a disorder that accounts for 2% to 3% of all melanoma cases.
  • We report the case of a 31-year-old male patient presenting with a rapidly growing mass localized to the hallux, which eventually resulted in the diagnosis of an ulcerated amelanotic subungual melanoma.
  • Because of their lack of pigmentation, amelanotic melanoma is frequently misdiagnosed for other more common forms of cutaneous compromise, and a delay in proper treatment because of failure to make the diagnosis can greatly decrease the likelihood of a favorable outcome.
  • [MeSH-major] Hallux. Melanoma, Amelanotic / pathology. Nail Diseases / pathology. Skin Neoplasms / pathology

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  • (PMID = 19232976.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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75. Zalaudek I, Ferrara G, Argenziano G, Kerl H: [Three important rules in dermatoscopy]. J Dtsch Dermatol Ges; 2007 May;5(5):422-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Dermoscopy / methods. Dermoscopy / standards. Melanoma, Amelanotic / pathology. Practice Guidelines as Topic. Practice Patterns, Physicians' / standards. Skin Neoplasms / pathology

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  • (PMID = 17451389.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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76. Minagawa A, Koga H, Sakaizawa K, Sano K, Saida T: Dermoscopic and histopathological findings of polymorphous vessels in amelanotic cutaneous metastasis of pigmented cutaneous melanoma. Br J Dermatol; 2009 May;160(5):1134-6
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  • [Title] Dermoscopic and histopathological findings of polymorphous vessels in amelanotic cutaneous metastasis of pigmented cutaneous melanoma.
  • [MeSH-major] Bowen's Disease / pathology. Melanoma / blood supply. Skin Neoplasms / blood supply

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  • (PMID = 19302066.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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77. Camerin M, Magaraggia M, Soncin M, Jori G, Moreno M, Chambrier I, Cook MJ, Russell DA: The in vivo efficacy of phthalocyanine-nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma. Eur J Cancer; 2010 Jul;46(10):1910-8
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  • [Title] The in vivo efficacy of phthalocyanine-nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma.
  • The efficiency of a Zn(II)-phthalocyanine disulphide (C11Pc), a compound with both phthalocyanine units bearing seven hexyl chains and a sulphur terminated C11 chain, as a photodynamic therapy (PDT) agent was investigated in C57 mice bearing a sub-cutaneously transplanted amelanotic melanoma.
  • Biodistribution studies at selected post-injection times showed that the nanoparticle-associated C11Pc was recovered in significantly larger amounts from all the examined tissues and the serum and yielded a greater selectivity of tumour targeting: thus, the ratio between the amount of phthalocyanine recovered from the amelanotic melanoma and the skin (peritumoural tissue) increased from 2.3 to 5.5 from the free to the gold nanoparticle-bound C11Pc at 24 h after injection.
  • PDT studies with the C11Pc-loaded amelanotic melanoma showed a markedly more significant response of the tumour in the mice that had received the nanoparticle-bound photosensitiser; the PDT effect was especially extensive if the irradiation was performed at 3h after C11Pc injection when large phthalocyanine amounts were still present in the serum.
  • [MeSH-major] Indoles / therapeutic use. Melanoma, Amelanotic / drug therapy. Metal Nanoparticles / therapeutic use. Organometallic Compounds / therapeutic use. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20356732.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / C22031/A7097
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Indoles; 0 / Organometallic Compounds; 0 / Photosensitizing Agents; 14320-04-8 / Zn(II)-phthalocyanine
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78. Schöttler L, Körber A, Denisjuk N, Freise J, Dissemond J: [Malignant melanoma masquerading as a neurotrophic ulcer]. Med Klin (Munich); 2009 Sep 15;104(9):723-6
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  • [Title] [Malignant melanoma masquerading as a neurotrophic ulcer].
  • [Transliterated title] Malignes Melanom imitiert ein neurotrophes Ulkus.
  • After the initial examination in the outpatient wound healing clinic, a malignant melanoma already showing invasive growth with a penetration depth of 4.6 mm was detected in a biopsy.
  • After diagnosis and exclusion of metastases, a phase-adapted complete excision was carried out.
  • CONCLUSION: Malignant melanoma is a primary cutaneous malignant tumor.
  • Its thickness at the time of the initial diagnosis is crucial to the prognosis.
  • Ulcerated and amelanotic melanomas still present a considerable clinical challenge due to the likelihood of being mistaken for benign diseases and the occurrence of filiae when diagnosis is made too late.
  • This case report demonstrates the importance of differential diagnostic consideration of neoplasias, for example malignant melanoma, in cases of unclear, therapy-refractory wounds and discusses the relevant aspects in avoiding an unnecessary prolongation of diagnostics.
  • [MeSH-major] Diabetic Foot / diagnosis. Diabetic Nephropathies / diagnosis. Heel. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Interferons / therapeutic use. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Sentinel Lymph Node Biopsy

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  • [Cites] Br J Dermatol. 2002 Apr;146 Suppl 61:24-30 [11966729.001]
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  • (PMID = 19779677.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 9008-11-1 / Interferons
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79. Choi TY, Sohn KC, Kim JH, Kim SM, Kim CH, Hwang JS, Lee JH, Kim CD, Yoon TJ: Impact of NAD(P)H:quinone oxidoreductase-1 on pigmentation. J Invest Dermatol; 2010 Mar;130(3):784-92
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  • We obtained metastasized melanoma tissue from a primary acral lentiginous melanoma (ALM) patient and established a melanoma cell line named primary culture of melanoma cell derived from lymph node (PML)-1.
  • To identify genes differentially regulated in PML-1 melanoma cells, we performed DNA microarray and two-dimensional matrix-assisted laser desorption ionization-time of flight mass spectrometry analyses.
  • Reverse transcription-PCR and western blot analyses showed that NQO1 was markedly decreased in PML-1 cells and in several amelanotic melanoma cell lines.
  • [MeSH-major] NAD(P)H Dehydrogenase (Quinone) / genetics. NAD(P)H Dehydrogenase (Quinone) / metabolism. Skin Pigmentation / genetics
  • [MeSH-minor] Adenoviridae / genetics. Alkaloids / biosynthesis. Animals. Biomarkers, Tumor / metabolism. Cell Line, Tumor. Gene Expression / physiology. Humans. Lymph Nodes / cytology. Melanins / biosynthesis. Melanocytes / cytology. Melanocytes / physiology. Melanoma / metabolism. Melanoma / physiopathology. Monophenol Monooxygenase / metabolism. Recombinant Proteins / genetics. Recombinant Proteins / metabolism. Skin Neoplasms / metabolism. Skin Neoplasms / physiopathology. Zebrafish

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  • [CommentIn] J Invest Dermatol. 2010 Mar;130(3):645-7 [20145642.001]
  • (PMID = 19759547.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Biomarkers, Tumor; 0 / Melanins; 0 / Recombinant Proteins; 6801-22-5 / melinonine F; EC 1.14.18.1 / Monophenol Monooxygenase; EC 1.6.5.2 / NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2 / NQO1 protein, human
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80. Vanover JC, Spry ML, Hamilton L, Wakamatsu K, Ito S, D'Orazio JA: Stem cell factor rescues tyrosinase expression and pigmentation in discreet anatomic locations in albino mice. Pigment Cell Melanoma Res; 2009 Dec;22(6):827-38
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  • Here, we extend this animal model by developing a compound mutant transgenic amelanotic animal defective at both the melanocortin 1 receptor (Mc1r) and tyrosinase (Tyr) loci.
  • Lastly, UV sensitivity of K14-Scf congenic animals depended mainly on the amount of eumelanin present in the skin.

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  • (PMID = 19682281.001).
  • [ISSN] 1755-148X
  • [Journal-full-title] Pigment cell & melanoma research
  • [ISO-abbreviation] Pigment Cell Melanoma Res
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R03 CA125782-01A1; United States / NIEHS NIH HHS / ES / T32 ES007266; United States / NCI NIH HHS / CA / R03 CA125782; United States / NIEHS NIH HHS / ES / T32 ES-07266-17; United States / NCI NIH HHS / CA / R21 CA127052; United States / NCI NIH HHS / CA / R21 CA127052-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Stem Cell Factor; EC 1.14.18.1 / Monophenol Monooxygenase; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
  • [Other-IDs] NLM/ NIHMS804777; NLM/ PMC4962694
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81. Cichorek M, Kozłowska K, Bryl E: The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. Cancer Biol Ther; 2007 Mar;6(3):346-53
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  • [Title] The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell.
  • Loss of pigment in hamster amelanotic melanoma line is accompanied by a faster growth rate, higher tumorigenicity and shorter animal survival time.
  • Thus, the malignancy of melanoma increases during the alteration of melanotic (Ma) into amelanotic (Ab) line.
  • As changes in the ability to undergo a spontaneous or induced apoptosis, and the role of caspases in this process during melanoma progression are not well defined, they were investigated in this work.
  • Cytochrome c release into cytosol, and the activation of effector caspases, estimated by PARP degradation clearly showed that during the spontaneous death in the cells from both melanoma lines intrinsic way of apoptosis was activated.
  • Confocal and cytometric flow analyses indicate that camptothecin (CPT) induced apoptosis with caspase activation by the intrinsic way only in the amelanotic melanoma cells, even though cells of the Ma line also underwent CPT-induced apoptosis (the content of TUNEL-positive cells increased).
  • Thus, our results suggest that melanoma progression, associated with a decreased ability to undergo spontaneous apoptosis but an increased susceptibility to CPT-induced apoptosis, relates to different levels of caspase activation; they also show that intrinsic way of apoptotis depends on the phenotype of melanoma cells, being more pronounced in the melanotic melanoma cells.
  • On the other hand, melanotic melanoma cells resistance to camptothecin-induced apoptosis suggests that the melanogenic apparatus or melanin itself may have the protective effect on the ability of the melanoma cells to undergo apoptosis.
  • [MeSH-major] Apoptosis. Caspases / metabolism. Melanoma, Amelanotic / enzymology. Melanoma, Experimental / enzymology. Skin Neoplasms / enzymology

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  • (PMID = 17312383.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Melanins; 9007-43-6 / Cytochromes c; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspases; XT3Z54Z28A / Camptothecin
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82. Matusiak L, Bieniek A, Wozniak Z, Szepietowski JC: Amelanotic malignant melanoma in an acral location. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Jun;17(2):72-4
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  • [Title] Amelanotic malignant melanoma in an acral location.
  • The biopsy, stained with H and E, revealed an anaplastic malignant tumor.
  • Additional immunochemical staining with Melan A allowed us to make the final diagnosis: amelanotic malignant melanoma (MM).
  • The melanoma was removed by amputation of digits IV and V, with partial removal of the metatarsal bones (Clark degree 5, Breslow thickness 9 mm).
  • [MeSH-major] Foot Dermatoses / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 18709293.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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83. Chen KG, Leapman RD, Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ, Gottesman MM: Influence of melanosome dynamics on melanoma drug sensitivity. J Natl Cancer Inst; 2009 Sep 16;101(18):1259-71
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  • [Title] Influence of melanosome dynamics on melanoma drug sensitivity.
  • BACKGROUND: Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood.
  • RESULTS: Endogenous melanogenic cytotoxicity, produced by damaged melanosomes, resulted in pronounced cell growth inhibition in MNT-1 cells compared with amelanotic SK-MEL-28 cells.
  • CONCLUSIONS: Melanosome dynamics (including their biogenesis, density, status, and structural integrity) regulate the drug resistance of melanoma cells.
  • Manipulation of melanosome functions may be an effective way to enhance the therapeutic activity of anticancer drugs against melanoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / pharmacology. Drug Resistance, Neoplasm. Melanoma / drug therapy. Melanoma / pathology. Melanosomes / drug effects. Melanosomes / ultrastructure. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology
  • [MeSH-minor] Animals. Cell Death / drug effects. Cell Line, Tumor. Cisplatin / pharmacology. Cyclosporins / pharmacology. Doxorubicin / pharmacology. Fluorescent Antibody Technique, Indirect. Humans. Melanoma, Experimental / drug therapy. Melanoma, Experimental / pathology. Mice. Microscopy, Confocal. Microscopy, Electron. Verapamil / pharmacology. Vinblastine / pharmacology

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  • (PMID = 19704071.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 NS999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclosporins; 121584-18-7 / valspodar; 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; CJ0O37KU29 / Verapamil; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ PMC2744727
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84. Jacob S, Pye E, Hbahbih M, Messios N, Rajabally YA: Rapidly progressive bilateral ophthalmoplegia and enlarging sellar mass caused by amelanotic melanoma. J Neuroophthalmol; 2006 Mar;26(1):49-50
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  • [Title] Rapidly progressive bilateral ophthalmoplegia and enlarging sellar mass caused by amelanotic melanoma.
  • Hypophysectomy disclosed an amelanotic melanoma.
  • Despite local radiation treatment, the tumor continued to grow and the patient became blind and died within several months of diagnosis.
  • There are seven reported cases of melanoma arising primarily in the sella turcica.
  • Two cases of metastatic melanoma to the cavernous sinuses have been reported.
  • Amelanotic melanoma has not been reported as a cause of cavernous sinus syndrome.
  • [MeSH-major] Melanoma, Amelanotic / complications. Ophthalmoplegia / etiology. Pituitary Neoplasms / complications. Sella Turcica / pathology
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Hypophysectomy. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16518168.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Blum A: 1st congress of the International Dermoscopy Society. Dermatology; 2006;213(4):337-40
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  • [MeSH-major] Dermoscopy. Skin Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Europe. Humans. Melanoma / diagnosis. Melanoma, Amelanotic / diagnosis. Nevus / diagnosis. Societies, Medical

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  • (PMID = 17135742.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Switzerland
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86. Abbes I, Sassi S, Dhouib R, Mrad K, Driss M, Limaiem F, Ben Romdhane K: Small cell malignant melanoma: an unusual morphologic variant. Pathologica; 2007 Dec;99(6):431-3
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  • [Title] Small cell malignant melanoma: an unusual morphologic variant.
  • Small cell melanoma is a recognized rare variant of malignant melanoma.
  • This case report draws attention to the difficulties encountered in the histological diagnosis of this rare variant of malignant melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Amputation. Antigens, Neoplasm / analysis. Biomarkers, Tumor. Female. Fingers / pathology. Fingers / surgery. Humans. Lymphatic Metastasis. MART-1 Antigen. Melanoma-Specific Antigens. Neoplasm Proteins / analysis

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  • (PMID = 18416335.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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87. De Simone P, Gelin M, El Nakadi I: Amelanotic malignant melanoma of the esophagus. Report of a case. Minerva Chir; 2006 Feb;61(1):45-9
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  • [Title] Amelanotic malignant melanoma of the esophagus. Report of a case.
  • Primary malignant melanomas of the esophagus are rare neoplasms with aggressive behavior and tendency to lymphatic and hematogenous spread.
  • We report on a patient affected with a primary amelanotic melanoma of the esophagus synchronous to a squamous cell carcinoma of the epiglottis and treated by subtotal esophagectomy.
  • Review of patient's medical history and exploration of skin and mucous membranes failed to reveal malignant lesions and definitive diagnosis was primary amelanotic malignant melanoma of the esophagus.
  • In conclusion the present case confirms that primary malignant melanomas of the esophagus have a dismal outcome even in cases of early-stage lesions amenable to surgical resection.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Epiglottis. Esophageal Neoplasms / pathology. Laryngeal Neoplasms / pathology. Melanoma / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 16568022.001).
  • [ISSN] 0026-4733
  • [Journal-full-title] Minerva chirurgica
  • [ISO-abbreviation] Minerva Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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88. Kurotaki T, Tomonari Y, Kanno T, Wako Y, Tsuchitani M: A novel immunohistochemical marker of normal and neoplastic melanocytes in formalin-fixed, paraffin-embedded tissues of albino rats. Vet Pathol; 2008 May;45(3):383-7
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  • In albino rats, spontaneous occurrence of melanocytic tumors is rare, with diagnosis difficult.
  • The samples consisted of 11 (1.57%) amelanotic melanomas in 700 rats (2 studies), 23 non-melanocytic tumors, and a wide variety of normal tissues.
  • In amelanotic melanoma, the tumor cells consisted of spindle cells with eosinophilic cytoplasm without melanin granules.
  • PNL2 consistently stained cytoplasm in all amelanotic melanoma cells.
  • [MeSH-major] Melanocytes / cytology. Melanocytes / pathology. Melanoma / pathology

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  • (PMID = 18487499.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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89. Braga JC, Scope A, Klaz I, Mecca P, González S, Rabinovitz H, Marghoob AA: The significance of reflectance confocal microscopy in the assessment of solitary pink skin lesions. J Am Acad Dermatol; 2009 Aug;61(2):230-41
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  • [Title] The significance of reflectance confocal microscopy in the assessment of solitary pink skin lesions.
  • The differential diagnosis for pink lesions tends, therefore, to be broad, ranging from inflammatory processes to malignancy.
  • OBJECTIVE: We sought to demonstrate the use of RCM as an adjunct to the bedside diagnosis of pink lesions.
  • METHODS: We describe a series of patients with clinically and dermatoscopically equivocal pink lesions for which RCM examination allowed for a rapid and accurate diagnosis.
  • RESULTS: Lesions included basal cell carcinoma, squamous cell carcinoma, amelanotic melanoma, and inflamed seborrheic keratosis.
  • In the cases presented RCM allowed for a rapid and accurate noninvasive diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Keratosis, Actinic / pathology. Melanoma / pathology. Microscopy, Confocal. Pigmentation Disorders / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Dermoscopy / methods. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Sampling Studies. Sensitivity and Specificity


90. Stroh C, Manger T: [Primary amelanotic anorectal melanoma--a case report]. Zentralbl Chir; 2007 Dec;132(6):560-3
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  • [Title] [Primary amelanotic anorectal melanoma--a case report].
  • [Transliterated title] Das primäre amelanotische Melanom des Rektums - Ein Fallbericht.
  • BACKGROUND: The amelanotic melanoma of the rectal mucosa is very rare with an unfavourable prognosis.
  • Therefore transrectal ultrasound is of major importance in the preoperative staging and postoperative follow-up especially in diagnosis of local recurrence by using the ultrasound-guided, transrectal aspiration.
  • METHODS: In literature 5 cases of amelanotic malignant melanoma were reported.
  • The overall survival time is 10 months after diagnosis.
  • RESULTS: We report about a 55-year-old female patient with an amelanotic melanoma of rectal mucosa.
  • The patient died 36 months after diagnosis.
  • CONCLUSION: The prognosis of primary malignant anorectal melanoma is poor, irrespective of surgical treatment.
  • Wide local resection is the first choice for primary anorectal melanoma.
  • Chemotherapy, radiotherapy and immunotherapy should be considered in the treatment of anorectal melanoma to influence the overall survival.
  • [MeSH-major] Melanoma, Amelanotic / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18098086.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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91. Sayk F, Mahnken A, Stellmacher F, Dalhoff K, Merz H: [Cancer-to-cancer metastasis: amelanotic melanoma into renal cell carcinoma]. Dtsch Med Wochenschr; 2010 Mar;135(11):507-10
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  • [Title] [Cancer-to-cancer metastasis: amelanotic melanoma into renal cell carcinoma].
  • DIAGNOSIS: The autopsy revealed that he was affected by two malignant neoplasms simultaneously: an amelanotic malignant melanoma metastasizing into a localized renal cell carcinoma.
  • This is the third reported case of a malignant melanoma as donor tumor spreading into a renal cell carcinoma.
  • The amelanotic character of the melanoma exerted a special diagnostic challenge.
  • Clinical and autopsy findings as well as the immunophenotypical features of the metastatic amelanotic melanoma (HMB-45, Melan-A/MART-1, S100) and the renal cell carcinoma are described with a review of the relevant literature.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Melanoma, Amelanotic / pathology

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 20221965.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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92. Harasymowycz P, Boucher MC, Corriveau C, Gauthier D, Allaire G: Choroidal amelanotic melanoma in a patient with oculocutaneous albinism. Can J Ophthalmol; 2005 Dec;40(6):754-8
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  • [Title] Choroidal amelanotic melanoma in a patient with oculocutaneous albinism.
  • CASE REPORT: We describe the clinical presentation of a choroidal amelanotic melanoma in a 46-year-old woman with oculocutaneous albinism.
  • Microscopic findings and histopathological features, demonstrating a spindle B-cell melanoma of the choroid, are also reviewed.
  • COMMENTS: Magnetic resonance imaging may be helpful in diagnosing amelanotic melanoma in patients with oculocutaneous albinism.

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  • (PMID = 16391642.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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93. Harrison TM, Dominguez P, Hanzlik K, Sikarskie JG, Agnew D, Bergin I, Fitzgerald SD, Kitchell BE, McNiel E: Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi). J Zoo Wildl Med; 2010 Mar;41(1):152-7
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  • [Title] Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi).
  • Immunohistochemically, the original, recurrent, and metastatic populations were strongly positive for HMB 45 and weakly positive for S-100, and the final diagnosis was metastatic amelanotic melanoma.
  • [MeSH-major] Insectivora. Melanoma, Amelanotic / veterinary

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  • (PMID = 20722271.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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94. Avilés-Izquierdo JA, Velázquez-Tarjuelo D, Lecona-Echevarría M, Lázaro-Ochaita P: [Dermoscopic features of eccrine poroma]. Actas Dermosifiliogr; 2009 Mar;100(2):133-6
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  • Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma.
  • Dermoscopy can improve the clinical diagnosis of this benign adnexal skin tumor.
  • [MeSH-minor] Aged. Aged, 80 and over. Buttocks. Diagnosis, Differential. Female. Humans. Skin Neoplasms / diagnosis

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  • (PMID = 19445878.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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95. Cavicchini S, Tourlaki A, Bottini S: Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma. Arch Dermatol; 2007 Apr;143(4):556
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  • [Title] Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / blood supply. Skin Neoplasms / blood supply

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  • (PMID = 17438200.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Ghiorzo P, Pastorino L, Pizzichetta MA, Bono R, Queirolo P, Talamini R, Annessi G, Bruno W, Nasti S, Gargiulo S, Battistuzzi L, Sini MC, Palmieri G, Scarrà GB, Italian Melanoma Intergroup: CDKN2A and MC1R analysis in amelanotic and pigmented melanoma. Melanoma Res; 2009 Jun;19(3):142-5
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  • [Title] CDKN2A and MC1R analysis in amelanotic and pigmented melanoma.
  • Amelanotic melanoma (AM) is a rare subtype of melanoma with little or no clinically visible pigment; it is more difficult to diagnose than pigmented melanoma (PM), and has a worse prognosis.
  • In the attempt to find a genetic explanation for the distinction between AM and PM, we conducted a case-case study, matching AM and PM patients, and testing them for germline mutations in high- (p16INK4A, p14ARF, CDK4) and low-penetrance (MC1R) melanoma susceptibility genes.
  • This rare mutation, which has been described only once previously, may be involved in predisposition to the amelanotic phenotype in combination with germline MC1R variants and coordinate somatic expression of pigmentation genes and their regulators.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Melanoma, Amelanotic / genetics. Receptor, Melanocortin, Type 1 / genetics. Skin Neoplasms / genetics. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 19339902.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Receptor, Melanocortin, Type 1; 0 / Tumor Suppressor Protein p14ARF
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97. André J, Moulonguet I, Goettmann-Bonvallot S: In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. Arch Dermatol; 2010 Apr;146(4):418-21
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  • [Title] In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases.
  • BACKGROUND: Nail apparatus melanoma is known to be associated with a poor prognosis, mainly because of a delay in diagnosis that is made at an invasive stage.
  • This delay is particularly true in cases involving amelanotic melanoma.
  • To our knowledge, only 1 case of in situ amelanotic melanoma of the nail unit has previously been described.
  • We report 3 cases of in situ amelanotic melanoma with clinical lichenoid features.
  • OBSERVATIONS: We describe 3 cases of in situ amelanotic melanoma of the nail unit.
  • Histologic examination revealed in situ amelanotic melanoma extending from the proximal matrix up to the distal part of the nail bed.
  • CONCLUSIONS: Monodactylic lichenoid nail changes should be added to the more conventional signs of incipient nail melanoma.
  • [MeSH-major] Lichen Planus / diagnosis. Melanoma, Amelanotic / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 20404232.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Pouckova P, Skvor J, Gotte G, Vottariello F, Slavik JT, Matousek J, Laurents DV, Libonati M, Soucek J: Some biological actions of PEG-conjugated RNase A oligomers. Neoplasma; 2006;53(1):79-85
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  • In this work we show that the chemical conjugation of PEG to the RNase A C-dimer, and to the two RNase A trimers (NC-trimer and C- trimer) decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB900518 amelanotic melanoma transplanted in athymic nude mice.
  • [MeSH-minor] Animals. Antispermatogenic Agents / pharmacology. Cell Line, Tumor. Dimerization. Embryo, Mammalian / drug effects. Humans. Male. Melanoma, Experimental / drug therapy. Mice. Neoplasm Transplantation. Spermatogenesis / drug effects

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  • (PMID = 16416018.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antispermatogenic Agents; 0 / Peptide Fragments; 30IQX730WE / Polyethylene Glycols; EC 3.1.27.5 / Ribonuclease, Pancreatic
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99. Koszałka P, Szmit E, Myśliwski A, Bigda J: Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters. Arch Immunol Ther Exp (Warsz); 2007 Jul-Aug;55(4):267-79
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  • [Title] Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters.
  • MATERIALS AND METHODS: The effects of intratumoral injection of rat TNF into hamsters bearing Bomirski Ab amelanotic melanoma, a fast growing tumor of high metastatic potential, were tested.
  • In vitro assays indicated a direct cytotoxic effect of TNF against Ab melanoma cells, most probably as an outcome of apoptosis.
  • Intratumoral application of TNF also caused some modulation of cytokine response in melanoma-bearing hamsters as evidenced by increased levels of IL-6 in blood serum.
  • CONCLUSIONS: This study established Bomirski Ab melanoma as a useful model for complex analysis of the anti-tumor activity of TNF.
  • [MeSH-major] Angiogenesis Inhibitors / metabolism. Melanoma, Experimental / metabolism. Neovascularization, Pathologic / metabolism. Recombinant Proteins / metabolism. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17659374.001).
  • [ISSN] 0004-069X
  • [Journal-full-title] Archivum immunologiae et therapiae experimentalis
  • [ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Cyclohexanes; 0 / Interleukin-6; 0 / Recombinant Proteins; 0 / Sesquiterpenes; 0 / Tumor Necrosis Factor-alpha; 129298-91-5 / O-(chloroacetylcarbamoyl)fumagillol
  • [Other-IDs] NLM/ PMC2766459
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100. Kato H, Inoue Y, Ishihara T, Kageshita T, Ihn H: Amelanotic malignant melanoma where primary lesion was discovered 5 years after metastasis in the lymph node. J Dermatol; 2010 Aug;37(8):730-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amelanotic malignant melanoma where primary lesion was discovered 5 years after metastasis in the lymph node.
  • He was diagnosed as having a malignant tumor of the soft tissues at a local hospital; however, an exact diagnosis was not obtained.
  • He was diagnosed as having amelanotic malignant melanoma and the lesion was resected.
  • In our hospital, we have experienced 16 cases of amelanotic malignant melanoma.
  • Generally, it is reported that the patients with amelanotic malignant melanoma have a poor prognosis, but we have observed no difference in the outcome between the patients with amelanotic malignant melanoma and those with malignant melanoma.
  • [MeSH-major] Foot Diseases / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Foot Injuries and Disorders.
  • MedlinePlus Health Information. consumer health - Skin Cancer.
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Hazardous Substances Data Bank. DACARBAZINE .
  • Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .
  • Hazardous Substances Data Bank. VINCRISTINE .
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  • (PMID = 20649717.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; CYVADIC protocol
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