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1. Hillenbrand A, Barth TF, Henne-Bruns D, Formentini A: Anorectal amelanotic melanoma. Colorectal Dis; 2008 Jul;10(6):612-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anorectal amelanotic melanoma.
  • OBJECTIVE: Anorectal melanoma is a rare, highly malignant tumour with a poor 5 year survival of 10%.
  • Most anorectal melanomas have gross and/or histologic pigmentation, however about 30% of anorectal melanomas are amelanotic.
  • METHOD: We report three cases of amelanotic anorectal melanomas and integrate our data with six case reports of amelanotic malignant melanoma from the literature.
  • Further we compare clinicopathological data and clinical outcome with large series of anorectal melanomas (both, amelanotic and pigmentated).
  • Rectal bleeding was the leading symptom in all cases with a mean duration of 4 months before diagnosis.
  • A tumour thickness of < 4 mm was correlated with long-term disease-free survival, whereas tumour thickness of 4 mm or more was correlated with systemic recurrence.
  • CONCLUSION: Early diagnosis is key for efficient treatment and improved survival rate for patients with this unusual variant of melanoma.
  • There is no difference in terms of age, time of diagnosis, stage and survival between pigmented and amelanotic anorectal melanoma.
  • [MeSH-major] Anus Neoplasms. Melanoma, Amelanotic. Rectal Neoplasms

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  • (PMID = 17944970.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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2. Gensburger M, Kodjikian L, Devouassoux-Shisheboran M, Grange JD: [Thirty-five years of follow-up before enucleation for malignant choroidal melanoma. A case report]. J Fr Ophtalmol; 2006 Mar;29(3):307-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thirty-five years of follow-up before enucleation for malignant choroidal melanoma. A case report].
  • We report the case of a patient with a unilateral chorioretinal lesion that evolved over 35 years before enucleation provided the diagnosis of amelanotic choroidal melanoma.
  • [MeSH-major] Choroid Neoplasms / surgery. Eye Enucleation. Melanoma / surgery

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  • (PMID = 16557176.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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3. von Felbert V, Abuzahra F: [Two rarely seen manifestations of malignant melanoma]. Hautarzt; 2007 May;58(5):390-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Two rarely seen manifestations of malignant melanoma].
  • [MeSH-major] Melanoma, Amelanotic / pathology. Nail Diseases / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Skin / pathology. Thyroid Neoplasms / pathology

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  • [Cites] Hautarzt. 2004 Jun;55(6):567-79; quiz 580-1 [15274247.001]
  • [Cites] Br J Dermatol. 2006 Sep;155(3):561-9 [16911282.001]
  • [Cites] J Am Acad Dermatol. 1989 Dec;21(6):1165-75 [2685057.001]
  • [Cites] Semin Cutan Med Surg. 1997 Jun;16(2):122-30 [9220551.001]
  • [Cites] Hautarzt. 1996 Nov;47(11):854-7 [9036140.001]
  • (PMID = 17447038.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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4. de Koning HD, Bovenschen HJ: Two adjacent nodules on the leg. Dermatol Online J; 2010;16(6):13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Poroma is a rare benign neoplasm (derived from the intraepidermal part of the eccrine or apocrine duct), which may clinically mimic malignant tumors such as (amelanotic) malignant melanoma and porocarcinoma.
  • Histopathological examination is the key to the correct diagnosis, which is illustrated in the present case, in which a pigmented basal cell carcinoma and a poroma are in close proximity to each other.
  • Despite a clinical differential diagnosis of melanoma, histopathology showed the typical characteristics of a poroma, a rare but much more favorable tumor.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Leg. Poroma / diagnosis. Sweat Gland Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 20579468.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Ayadi L, Chaari C, Masmoudi A, Khabir A, Masmoudi A, Ellouze Z, Turki H, Keskes H, Frikha M, Makni S, Sellami Boudawara T: [Amelanotic spitzoid melanoma of the digit: case report]. Tunis Med; 2009 Mar;87(3):210-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Amelanotic spitzoid melanoma of the digit: case report].
  • [Transliterated title] Melanome spitzoide achromique du doigt: à propos d'une observation.
  • BACKGROUND: Melanomas of digit is rare, accounting for 1% of all cutaneous melanomas.
  • AIM: Our purpose is to discuss the clinicopathological characteristics and the difficulties encountred in establishing diagnosis of this rare tumor.
  • OBSERVATION: we report the case of a 25-years-old woman, who consulted for nodular and ulcerated lesion of the right index, located in the external face of the metacarpo-phalangeal joint.
  • The nodule was biopsied and histopathologic exam concluded to spitzoid melanoma.
  • CONCLUSION: In our report, clinical presentation was misleading causing a diagnosis and therapeutic delay.
  • Pathologically, all the histological types of melanoma were described in the digit except spitzoid melanoma.
  • [MeSH-major] Fingers / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 19537017.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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6. Avilés-Izquierdo JA, Velázquez-Tarjuelo D, Lecona-Echevarría M, Lázaro-Ochaita P: [Dermoscopic features of eccrine poroma]. Actas Dermosifiliogr; 2009 Mar;100(2):133-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma.
  • Dermoscopy can improve the clinical diagnosis of this benign adnexal skin tumor.
  • [MeSH-minor] Aged. Aged, 80 and over. Buttocks. Diagnosis, Differential. Female. Humans. Skin Neoplasms / diagnosis

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  • (PMID = 19445878.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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7. Denoyer D, Greguric I, Roselt P, Neels OC, Aide N, Taylor SR, Katsifis A, Dorow DS, Hicks RJ: High-contrast PET of melanoma using (18)F-MEL050, a selective probe for melanin with predominantly renal clearance. J Nucl Med; 2010 Mar;51(3):441-7
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  • [Title] High-contrast PET of melanoma using (18)F-MEL050, a selective probe for melanin with predominantly renal clearance.
  • The aim of this study was to evaluate the novel probe (18)F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide ((18)F-MEL050) for the imaging of primary and metastatic melanoma.
  • METHODS: PET using (18)F-MEL050 was performed in murine models of melanoma.
  • The specificity of (18)F-MEL050 was studied by comparing its accumulation in pigmented B16-F0 allograft tumors with that of human amelanotic A375 xenografts using PET and high-resolution autoradiography. (18)F-MEL050 PET results were compared with (18)F-FDG PET, the current standard in melanoma molecular imaging.
  • To test the ability of (18)F-MEL050 to assess the metastatic spread of melanoma, a murine model of lung metastasis was imaged by PET/CT, and results correlated with physical assessment of tumor burden in the lungs.
  • In the B16-F0 melanoma allograft model, tumor-to-background ratio was more than 9-fold higher for (18)F-MEL050 than for (18)F-FDG (50.9 +/- 6.9 vs. 5.8 +/- 0.5).
  • No uptake was observed in the amelanotic melanoma xenografts.
  • CONCLUSION: (18)F-MEL050 has a rapid tumor uptake and high retention with specificity for melanin, suggesting great potential for noninvasive clinical evaluation of suspected metastatic melanoma.
  • [MeSH-major] Fluorine Radioisotopes / chemistry. Kidney / metabolism. Melanins / metabolism. Melanoma / radionuclide imaging. Niacinamide / analogs & derivatives. Positron-Emission Tomography. Pyridines / metabolism

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  • Hazardous Substances Data Bank. NICOTINAMIDE .
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  • (PMID = 20150254.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Fluorine Radioisotopes; 0 / Melanins; 0 / N-(2-(diethylamino)ethyl)-6-fluoronicotinamide; 0 / Pyridines; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 25X51I8RD4 / Niacinamide
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8. Khaled A, Hammami H, Fazaa B, Kourda N, Kamoun MR, Ben Jilany S, Zoghlami A: Primary amelanotic anorectal melanoma: an uncommon neoplasia with poor prognosis. Pathologica; 2009 Jun;101(3):126-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary amelanotic anorectal melanoma: an uncommon neoplasia with poor prognosis.
  • BACKGROUND: Anorectal melanoma is a rare and aggressive mucosal cancer.
  • There is usually a delay in diagnosis because about 30% of these cancers are amelanotic and are often mistaken for benign conditions.
  • Herein, we report a case of amelanotic anorectal malignant melanoma with an unusual metastatic deposit in the vulva and also review the literature.
  • Clinical examination showed a pedunculated and ulcerated amelanotic tumour associated with three other nodules, 1 cm in diameter, localized in the vulval mucosa.
  • Histological examination and immunohistochemical staining of all tumours demonstrated malignant melanoma.
  • DISCUSSION: Nine cases of amelanotic malignant melanoma have been reported in the literature.
  • The age at diagnosis ranged from 45 to 77 years.
  • Anorectal melanoma is most common in the rectum, followed by the anal canal.
  • Our case is the tenth case of amelanotic anorectal melanoma and probably corresponds to multiple synchronous primary melanomas of the anorectal region and the vulva, with the possibility that one of the lesions is a primary melanoma and the others are satellite lesions.
  • [MeSH-major] Anus Neoplasms / pathology. Melanoma, Amelanotic / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19886548.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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9. Rizvi SA, Amitava AK, Mehdi G, Sharma R, Alam MS: Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association. Indian J Ophthalmol; 2008 Sep-Oct;56(5):421-3
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  • [Title] Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association.
  • Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder of DNA repair in which the body's normal ability to repair damage caused by ultraviolet light is deficient.
  • Ocular neoplasms occurring in XP in order of frequency are squamous cell carcinoma, basal cell carcinoma and melanoma.
  • Malignant melanomas occur at an early age in patients with XP.
  • We report a case of XP with massive orbital melanoma in an eight-year-old boy which is unique due to its amelanotic presentation confirmed histopathologically.
  • [MeSH-major] Melanoma, Amelanotic / complications. Orbit. Skin Neoplasms / complications. Xeroderma Pigmentosum / complications
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Ophthalmologic Surgical Procedures / methods

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  • [Cites] Ann Intern Med. 1974 Feb;80(2):221-48 [4811796.001]
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  • (PMID = 18711275.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2636150
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10. Tundis R, Deguin B, Loizzo MR, Bonesi M, Statti GA, Tillequin F, Menichini F: Potential antitumor agents: flavones and their derivatives from Linaria reflexa Desf. Bioorg Med Chem Lett; 2005 Nov 1;15(21):4757-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The antiproliferative activity of several flavonoids isolated from Linaria reflexa Desf. (Scrophulariaceae) was evaluated in vitro by the SRB assay against the large cell lung carcinoma cell line COR-L23, hepatocellular carcinoma cell line HepG-2, renal adenocarcinoma cell line ACHN, amelanotic melanoma cell line C32, colorectal adenocarcinoma cell line Caco-2, and normal human fetal lung MRC5.

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  • (PMID = 16125932.001).
  • [ISSN] 0960-894X
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Chromones; 0 / Flavones; 28978-02-1 / pectolinarin
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11. Collins JD: A man with pain and a large nevus on his thigh. J Natl Med Assoc; 2010 Jul;102(7):647-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Bone Neoplasms / diagnosis. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Diagnosis, Differential. Fever / etiology. Humans. Male. Pain / etiology. Weight Loss

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  • (PMID = 20690329.001).
  • [ISSN] 1943-4693
  • [Journal-full-title] Journal of the National Medical Association
  • [ISO-abbreviation] J Natl Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Siddaraju N, Yaranal PJ, Mishra MM, Soundararaghavan J: Fine needle aspiration cytology in recurrent amelanotic melanoma: a case report. Acta Cytol; 2007 Sep-Oct;51(5):829-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fine needle aspiration cytology in recurrent amelanotic melanoma: a case report.
  • BACKGROUND: Amelanotic melanoma can mimic a wide variety of epithelial and nonepithelial malignant tumors.
  • Varied cytomorphology of melanoma has been described on exfoliative and fine needle aspiration cytology (FNAC).
  • We report a case of recurrent amelanotic melanoma to highlight its varied cytomorphologic features, which may cause diagnostic problems on cytologic and on histologic examinations.
  • FNAC revealed malignant cells with highly varied morphology with plasmacytoid and pleomorphic malignant cells with occasional fibrocollagenous tissue strands showing adherent neoplastic cells.
  • A cytologic diagnosis of pleomorphic malignant tumor was suggested, and the original histologic slides were reviewed; they showed a striking alveolar pattern that vaguely resembled an alveolar rhabdomyosarcoma.
  • A final diagnosis of amelanotic melanoma was made.
  • CONCLUSION: Awareness of the highly varied cytomorphology of amelanotic melanoma minimizes the diagnostic difficulty on fine needle aspiration smears.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology

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  • (PMID = 17910357.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Loizzo MR, Tundis R, Menichini F, Saab AM, Statti GA, Menichini F: Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells. Cell Prolif; 2008 Dec;41(6):1002-1012
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells.
  • Antiproliferative activity was tested on amelanotic melanoma C32 cells and on renal cell adenocarcinoma cells, using the sulphorhodamine B assay.
  • RESULTS: Cupressus sempervirens ssp. pyramidalis leaf oil exerted the highest cytotoxic activity with an IC(50)value of 104.90 microg/mL against C32, followed by activity of P. orientalis and P. asperula on the renal adenocarcinoma cell line (IC(50) of 121.93 and 139.17 microg/mL, respectively). P. orientalis essential oil was also active against amelanotic melanoma with an IC(50) of 330.04 microg/mL.
  • [MeSH-major] Carcinoma, Renal Cell / drug therapy. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / drug therapy. Melanoma, Amelanotic / drug therapy. Melanoma, Amelanotic / pathology. Oils, Volatile / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 19040575.001).
  • [ISSN] 1365-2184
  • [Journal-full-title] Cell proliferation
  • [ISO-abbreviation] Cell Prolif.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oils, Volatile; 0 / Plant Oils; 0 / Terpenes
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14. Nabeshima T, Kimura K, Kurosaka D: Amelanotic malignant melanoma of the conjunctiva in a young adult. Jpn J Ophthalmol; 2008 Sep-Oct;52(5):407-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amelanotic malignant melanoma of the conjunctiva in a young adult.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanoma, Amelanotic / pathology

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  • (PMID = 18991044.001).
  • [ISSN] 0021-5155
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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15. Oburu E, Gregori A: Relearning the lesson -- amelanotic malignant melanoma: a case report. J Med Case Rep; 2008;2:31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relearning the lesson -- amelanotic malignant melanoma: a case report.
  • Although not as common as the other melanomas, amelanotic melanoma often evades diagnosis by masquerading as other pathology.
  • We present a patient who was diagnosed and managed as having paronychia of the middle finger while in actual fact he had a subungual amelanotic melanoma.
  • Our case underlies the importance of early recognition and referral of this rare but malignant lesion by primary care physicians.

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  • (PMID = 18237392.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2267474
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16. Tundis R, Loizzo MR, Bonesi M, Menichini F, Statti GA, Menichini F: In vitro cytotoxic activity of Salsola oppositifolia Desf. (Amaranthaceae) in a panel of tumour cell lines. Z Naturforsch C; 2008 May-Jun;63(5-6):347-54
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  • The n-hexane fraction demonstrated an effective cytotoxic activity on the large lung carcinoma and amelanotic melanoma cell lines with IC50 values of 19.1 microg/ml and 24.4 microg/ml, respectively.
  • [MeSH-minor] Amaranthaceae / chemistry. Breast Neoplasms. Cell Line, Tumor. Female. Gas Chromatography-Mass Spectrometry. Humans. Kidney Neoplasms. Melanoma. Methanol. Paclitaxel / isolation & purification. Paclitaxel / pharmacology. Phenols / isolation & purification. Phenols / pharmacology. Plant Extracts / isolation & purification. Plant Extracts / pharmacology. Vinblastine / isolation & purification. Vinblastine / pharmacology

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  • (PMID = 18669019.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Phenols; 0 / Plant Extracts; 5V9KLZ54CY / Vinblastine; P88XT4IS4D / Paclitaxel; Y4S76JWI15 / Methanol
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17. Mandato VD, Kobal B, Di Stefano A, Sinkovec J, Levicnik A, Rakar S, Costagliola L: Amelanotic malignant melanoma of the uterine cervix with ten-year follow-up. Eur J Gynaecol Oncol; 2009;30(1):106-9
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  • [Title] Amelanotic malignant melanoma of the uterine cervix with ten-year follow-up.
  • BACKGROUND: Malignant melanoma (MM) accounts for 3% of cancers that affect women and results in less than 1% of cancer deaths.
  • Fewer than ten cases of amelanotic MM (AMM) have been reported in literature.
  • The patient is clinically free of disease ten years postoperatively.
  • CONCLUSION: Malignant melanoma of the cervix is often misdiagnosed because of non discriminatory features and the capacity to mimic other tumors.
  • Malignant melanoma of the cervix needs to be diagnosed as quickly as possible because a timely therapy and a long and careful follow-up might result in better survival.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology. Uterine Cervical Neoplasms / pathology


18. Abbes I, Sassi S, Dhouib R, Mrad K, Driss M, Limaiem F, Ben Romdhane K: Small cell malignant melanoma: an unusual morphologic variant. Pathologica; 2007 Dec;99(6):431-3
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  • [Title] Small cell malignant melanoma: an unusual morphologic variant.
  • Small cell melanoma is a recognized rare variant of malignant melanoma.
  • We report a case of a brown, ulcerated papule on the left third finger of an 80-year-old woman.
  • This case report draws attention to the difficulties encountered in the histological diagnosis of this rare variant of malignant melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Amputation. Antigens, Neoplasm / analysis. Biomarkers, Tumor. Female. Fingers / pathology. Fingers / surgery. Humans. Lymphatic Metastasis. MART-1 Antigen. Melanoma-Specific Antigens. Neoplasm Proteins / analysis

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  • (PMID = 18416335.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / MART-1 Antigen; 0 / MLANA protein, human; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins
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19. Gaustad JV, Benjaminsen IC, Graff BA, Brurberg KG, Ruud EB, Rofstad EK: Intratumor heterogeneity in blood perfusion in orthotopic human melanoma xenografts assessed by dynamic contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging; 2005 Jun;21(6):792-800
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  • [Title] Intratumor heterogeneity in blood perfusion in orthotopic human melanoma xenografts assessed by dynamic contrast-enhanced magnetic resonance imaging.
  • PURPOSE: To determine the intratumor heterogeneity in blood perfusion of orthotopic human melanoma xenografts by use of gadopentetate dimeglumine (Gd-DTPA)-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
  • MATERIALS AND METHODS: Orthotopic xenografts of an amelanotic human melanoma cell line (A-07) were scanned sagittally, coronally, and axially in three subsequent DCE-MRI sessions, using spoiled gradient recalled sequences, a voxel size of 0.31x0.62x2.0 mm3, and an interleaving acquisition method to avoid slice gaps.
  • CONCLUSION: Orthotopic human melanoma xenografts show significant intratumor heterogeneity in blood perfusion.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Melanoma, Experimental / blood supply

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15906326.001).
  • [ISSN] 1053-1807
  • [Journal-full-title] Journal of magnetic resonance imaging : JMRI
  • [ISO-abbreviation] J Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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20. Harrison TM, Dominguez P, Hanzlik K, Sikarskie JG, Agnew D, Bergin I, Fitzgerald SD, Kitchell BE, McNiel E: Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi). J Zoo Wildl Med; 2010 Mar;41(1):152-7
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  • [Title] Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi).
  • Immunohistochemically, the original, recurrent, and metastatic populations were strongly positive for HMB 45 and weakly positive for S-100, and the final diagnosis was metastatic amelanotic melanoma.
  • [MeSH-major] Insectivora. Melanoma, Amelanotic / veterinary

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  • (PMID = 20722271.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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21. Pizzichetta MA, Canzonieri V, Massarut S, Baresic T, Borsatti E, Menzies SW: Pitfalls in the dermoscopic diagnosis of amelanotic melanoma. J Am Acad Dermatol; 2010 May;62(5):893-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pitfalls in the dermoscopic diagnosis of amelanotic melanoma.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Necrosis

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  • [CommentOn] J Am Acad Dermatol. 2007 Mar;56(3):508-13 [17113189.001]
  • (PMID = 20398822.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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22. Kusick S, Bertram H, Oberleithner H, Ludwig T: Nanoscale imaging and quantification of local proteolytic activity. J Cell Physiol; 2005 Sep;204(3):767-74
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  • Malignant cells secrete most proteases as inactive proenzymes that undergo proteolytic cleavage for activation, and proteolytic activity is elevated in close proximity to these cells.
  • Amelanotic melanoma cells (A7-clone) were seeded on fluorescent gelatin or collagen-IV coatings.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15744770.001).
  • [ISSN] 0021-9541
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Proteins; EC 3.4.- / Peptide Hydrolases
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23. Aksu Çerman A, Demirçay Z, Demirkesen C: Amelanotic melanoma presenting as contact dermatitis. Eur J Dermatol; 2010 Nov-Dec;20(6):857-8
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  • [Title] Amelanotic melanoma presenting as contact dermatitis.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Dermatitis, Allergic Contact / diagnosis. Diagnosis, Differential. Ear, External. Female. Humans. Middle Aged

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  • (PMID = 20956099.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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24. Karakis I, McGeeney B, Demierre MF, Thiele JJ, Wolpowitz D, Bhawan J: Acquired hypopigmentation (leukoderma) as a presenting feature of metastatic amelanotic melanoma with brain involvement. Arch Neurol; 2007 Dec;64(12):1786-7
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  • [Title] Acquired hypopigmentation (leukoderma) as a presenting feature of metastatic amelanotic melanoma with brain involvement.
  • [MeSH-major] Brain Neoplasms / secondary. Hypopigmentation / etiology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 18071045.001).
  • [ISSN] 0003-9942
  • [Journal-full-title] Archives of neurology
  • [ISO-abbreviation] Arch. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antineoplastic Agents, Alkylating; 7GR28W0FJI / Dacarbazine; 7S5I7G3JQL / Dexamethasone; 85622-93-1 / temozolomide
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25. Conforti F, Loizzo MR, Statti AG, Menichini F: Cytotoxic activity of antioxidant constituents from Hypericum triquetrifolium Turra. Nat Prod Res; 2007 Jan;21(1):42-6
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  • Methanolic extract and pure compounds were tested against the large cell lung carcinoma cell line COR-L23, the hepatocellular carcinoma cell line HepG-2, renal cell adenocarcinoma ACHN, the amelanotic melanoma cell line C32 and normal human foetal lung MRC5.

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  • (PMID = 17365688.001).
  • [ISSN] 1478-6419
  • [Journal-full-title] Natural product research
  • [ISO-abbreviation] Nat. Prod. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Antioxidants; 0 / Flavonoids; 0 / Fluorescent Dyes; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols; 0 / Rhodamines; 2609-88-3 / lissamine rhodamine B
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26. Cunha D, Pacheco FA, Cardoso J: Vitiligo: a good prognostic factor in melanoma? Dermatol Online J; 2009;15(2):15
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  • [Title] Vitiligo: a good prognostic factor in melanoma?
  • The association of vitiligo with immunologic therapy for melanoma is generally regarded as a good prognostic factor.
  • The authors report the case of a 71-year-old Caucasian woman who had a malignant melanoma on the posterior aspect of the left leg in 1982.
  • Sixteen years later two amelanotic malignant melanoma metastases were observed on the left inferior limb and were excised.
  • Despite the two year gap between the appearance of vitiligo and interferon treatment, the former might be indicative of a delayed immunological response against the melanoma cells, supporting the concept of a better therapeutic outcome in this cluster of patients.
  • [MeSH-major] Interferons / therapeutic use. Melanoma / complications. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / complications. Vitiligo / complications

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  • (PMID = 19336032.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 9008-11-1 / Interferons
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27. Duggal R, Srinivasan R: Primary amelanotic melanoma of the cervix: case report with review of literature. J Gynecol Oncol; 2010 Sep;21(3):199-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary amelanotic melanoma of the cervix: case report with review of literature.
  • Primary malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis.
  • It may be misdiagnosed especially when amelanotic, in which case immunohistochemistry is useful in reaching the diagnosis.
  • We present one such case of a 65-year-old postmenopausal female patient presenting with bleeding per vaginum.
  • On histopathological examination it was originally suspected to be a poorly differentiated carcinoma or a non-epithelial malignant tumor, but was subsequently correctly diagnosed by immunohistochemical staining with the HMB-45 antibody and S-100 protein.

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  • (PMID = 20922145.001).
  • [ISSN] 2005-0399
  • [Journal-full-title] Journal of gynecologic oncology
  • [ISO-abbreviation] J Gynecol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2948230
  • [Keywords] NOTNLM ; Aamelanotic melanoma / HMB-45 antibody
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28. Braga JC, Scope A, Klaz I, Mecca P, González S, Rabinovitz H, Marghoob AA: The significance of reflectance confocal microscopy in the assessment of solitary pink skin lesions. J Am Acad Dermatol; 2009 Aug;61(2):230-41
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  • [Title] The significance of reflectance confocal microscopy in the assessment of solitary pink skin lesions.
  • BACKGROUND: Solitary pink lesions often manifest nondescript clinical and dermatoscopic primary morphologic features.
  • The differential diagnosis for pink lesions tends, therefore, to be broad, ranging from inflammatory processes to malignancy.
  • OBJECTIVE: We sought to demonstrate the use of RCM as an adjunct to the bedside diagnosis of pink lesions.
  • METHODS: We describe a series of patients with clinically and dermatoscopically equivocal pink lesions for which RCM examination allowed for a rapid and accurate diagnosis.
  • RESULTS: Lesions included basal cell carcinoma, squamous cell carcinoma, amelanotic melanoma, and inflamed seborrheic keratosis.
  • In the cases presented RCM allowed for a rapid and accurate noninvasive diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Keratosis, Actinic / pathology. Melanoma / pathology. Microscopy, Confocal. Pigmentation Disorders / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biopsy, Needle. Dermoscopy / methods. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Sampling Studies. Sensitivity and Specificity


29. Arbab AS, Janic B, Knight RA, Anderson SA, Pawelczyk E, Rad AM, Read EJ, Pandit SD, Frank JA: Detection of migration of locally implanted AC133+ stem cells by cellular magnetic resonance imaging with histological findings. FASEB J; 2008 Sep;22(9):3234-46
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  • AC133(+) cells labeled with ferumoxide-protamine sulfate were mixed with either rat glioma or human melanoma cells and implanted in flank of nude mice.

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  • (PMID = 18556461.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA122031; United States / Intramural NIH HHS / / Z01 CL090007-01; United States / NCI NIH HHS / CA / 5R01CA122031
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Chemokine CXCL12; 0 / Cxcl12 protein, mouse; 0 / Glycoproteins; 0 / Hif1a protein, mouse; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Magnetite Nanoparticles; 0 / Oxides; 0 / Peptides; 0 / Platelet-Derived Growth Factor; 0 / Protamines; 0 / Vascular Endothelial Growth Factor A; E1UOL152H7 / Iron; EC 3.4.24.24 / Matrix Metalloproteinase 2; G6N3J05W84 / ferumoxides; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
  • [Other-IDs] NLM/ PMC2518252
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30. Hasegawa S, Maruyama K, Takenaka H, Furukawa T, Saga T: A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution. Proc Natl Acad Sci U S A; 2009 Aug 18;106(33):13832-7
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  • We established medaka melanoma (MM) cells stably expressing GFP and transplanted them into nonirradiated and irradiated medaka.
  • [MeSH-major] Disease Models, Animal. Microscopy, Fluorescence / instrumentation. Neoplasm Transplantation / methods
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Proliferation. Cell Transplantation. Green Fluorescent Proteins / metabolism. Humans. Melanoma, Amelanotic / metabolism. Melanoma, Amelanotic / pathology. Neoplasm Metastasis. Oryzias. X-Rays

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  • [Cites] Cell. 2008 Dec 12;135(6):987-90 [19070562.001]
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  • (PMID = 19666513.001).
  • [ISSN] 1091-6490
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147336-22-9 / Green Fluorescent Proteins
  • [Other-IDs] NLM/ PMC2728980
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31. Cichorek M, Kozłowska K, Bryl E: The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell. Cancer Biol Ther; 2007 Mar;6(3):346-53
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  • [Title] The activity of caspases in spontaneous and camptothecin-induced death of melanotic and amelanotic melanoma cell.
  • Loss of pigment in hamster amelanotic melanoma line is accompanied by a faster growth rate, higher tumorigenicity and shorter animal survival time.
  • Thus, the malignancy of melanoma increases during the alteration of melanotic (Ma) into amelanotic (Ab) line.
  • As changes in the ability to undergo a spontaneous or induced apoptosis, and the role of caspases in this process during melanoma progression are not well defined, they were investigated in this work.
  • Cytochrome c release into cytosol, and the activation of effector caspases, estimated by PARP degradation clearly showed that during the spontaneous death in the cells from both melanoma lines intrinsic way of apoptosis was activated.
  • Confocal and cytometric flow analyses indicate that camptothecin (CPT) induced apoptosis with caspase activation by the intrinsic way only in the amelanotic melanoma cells, even though cells of the Ma line also underwent CPT-induced apoptosis (the content of TUNEL-positive cells increased).
  • Thus, our results suggest that melanoma progression, associated with a decreased ability to undergo spontaneous apoptosis but an increased susceptibility to CPT-induced apoptosis, relates to different levels of caspase activation; they also show that intrinsic way of apoptotis depends on the phenotype of melanoma cells, being more pronounced in the melanotic melanoma cells.
  • On the other hand, melanotic melanoma cells resistance to camptothecin-induced apoptosis suggests that the melanogenic apparatus or melanin itself may have the protective effect on the ability of the melanoma cells to undergo apoptosis.
  • [MeSH-major] Apoptosis. Caspases / metabolism. Melanoma, Amelanotic / enzymology. Melanoma, Experimental / enzymology. Skin Neoplasms / enzymology
  • [MeSH-minor] Animals. Antineoplastic Agents / toxicity. Camptothecin / toxicity. Cell Line, Tumor. Cricetinae. Cytochromes c / metabolism. Disease Progression. Flow Cytometry. Male. Melanins / metabolism. Mesocricetus. Microscopy, Confocal. Poly(ADP-ribose) Polymerases / metabolism

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  • (PMID = 17312383.001).
  • [ISSN] 1538-4047
  • [Journal-full-title] Cancer biology & therapy
  • [ISO-abbreviation] Cancer Biol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Melanins; 9007-43-6 / Cytochromes c; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / Caspases; XT3Z54Z28A / Camptothecin
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32. de Giorgi V, Sestini S, Massi D, Maio V, Giannotti B: Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study. J Am Acad Dermatol; 2006 Feb;54(2):341-4
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  • [Title] Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study.
  • Completely amelanotic melanomas are rare and therefore often misclassified, with tragic consequences for patients.
  • The analysis of the vascular pattern, which is often the only dermoscopic parameter to be seen, is therefore essential for a correct diagnosis.
  • We present a case of "true" amelanotic melanoma on the forehead of an 89-year-old man, which clinically mimicked squamous cell carcinoma.
  • The dermoscopic diagnostic algorithms routinely used for pigmented lesions are not helpful in diagnosing amelanotic melanoma because they are based on specific parameters not normally seen in amelanotic lesions.
  • In the light of our experience, pattern analysis is the most reliable method for diagnosing these particular lesions correctly because it allows in-depth morphologic analysis of the few parameters found.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology
  • [MeSH-minor] Aged. Algorithms. Humans. Male. Melanocytes / pathology. Skin Neoplasms / pathology

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  • [CommentIn] J Am Acad Dermatol. 2006 Oct;55(4):728 [17010767.001]
  • (PMID = 16443072.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Kanoh M, Amoh Y, Tanabe K, Maejima H, Takasu H, Katsuoka K: Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma. J Dermatol; 2010 Jun;37(6):505-11
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  • [Title] Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma.
  • In the present study, we examined the expression of the hair follicle and neural stem cell marker nestin, as well as S-100 and HMB-45, in melanoma.
  • Nestin immunoreactivity was observed in the HMB-45-negative melanoma cells in all five cases of amelanotic nodular melanomas.
  • Moreover, nestin immunoreactivity was observed in the dermal parts in seven of 10 cases of melanotic nodular melanomas.
  • Especially, nestin immunoreactivity was observed in the HMB-45-negative melanoma cells in the dermal parts of all 10 cases of HMB-45-negative amelanotic and melanotic nodular melanomas.
  • On the other hand, nestin expression was negative in 10 of 12 cases of superficial spreading melanoma.
  • These results suggest that nestin is an important marker of HMB-45-negative melanoma cells in the dermal parts of patients with nodular melanoma.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Intermediate Filament Proteins / metabolism. Melanoma / metabolism. Nerve Tissue Proteins / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / metabolism. Female. Humans. Immunohistochemistry. Male. Melanoma-Specific Antigens. Middle Aged. Neoplasm Proteins / metabolism. Nestin. Skin / pathology. Young Adult

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  • (PMID = 20536663.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / Melanoma-Specific Antigens; 0 / NES protein, human; 0 / Neoplasm Proteins; 0 / Nerve Tissue Proteins; 0 / Nes protein, mouse; 0 / Nestin
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34. Soucek P, Cihelkova I: Photodynamic therapy with verteporfin in subfoveal amelanotic choroidal melanoma (A controlled case). Neuro Endocrinol Lett; 2006 Feb-Apr;27(1-2):145-8
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  • [Title] Photodynamic therapy with verteporfin in subfoveal amelanotic choroidal melanoma (A controlled case).
  • A 57-year old man with 2.7 mm thick subfoveal amelanotic choroidal melanoma of the right eye was indicated for photodynamic therapy with verteporfin.
  • The disease did not recur during 24-month follow-up.
  • [MeSH-major] Eye Neoplasms / therapy. Melanoma, Amelanotic / therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use. Porphyrins / therapeutic use

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  • (PMID = 16648785.001).
  • [ISSN] 0172-780X
  • [Journal-full-title] Neuro endocrinology letters
  • [ISO-abbreviation] Neuro Endocrinol. Lett.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 129497-78-5 / verteporfin
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35. Ludwig T, Fakih S, Bertram H, Krebs B, Oberleithner H: New imidazole-coordinated chemotherapeutics with low epithelial toxicity. Cell Biochem Biophys; 2006;45(1):31-41
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  • The chlorine substituted NICE had no effect on epithelial integrity but markedly cytotoxic activity against amelanotic melanoma cells.

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  • (PMID = 16679562.001).
  • [ISSN] 1085-9195
  • [Journal-full-title] Cell biochemistry and biophysics
  • [ISO-abbreviation] Cell Biochem. Biophys.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Imidazoles; 0 / Ligands; 0 / Organic Cation Transport Proteins; 0 / Organoplatinum Compounds; BG3F62OND5 / Carboplatin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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36. Heidemann J, Lebiedz P, Herbst H, Spahn TW, Domagk D, Domschke W, Kucharzik T: Amelanotic malignant melanoma of the esophagus: case report. Z Gastroenterol; 2005 Jun;43(6):597-600
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  • [Title] Amelanotic malignant melanoma of the esophagus: case report.
  • We present the case of a primary malignant esophageal melanoma arising in a 75-year-old male, initially diagnosed as anaplastic squamous cell carcinoma.
  • After resection of the tumor, histological work-up was indicative of a marked morphological heterogeneity, resembling a focally amelanotic primary malignant melanoma.
  • Primary malignant melanomas of the esophagus are exceptionally rare.
  • An exact preoperative diagnosis is critical with respect to the appropriate therapeutic strategy.
  • [MeSH-major] Carcinoma, Squamous Cell / radiography. Esophageal Neoplasms / pathology. Esophageal Neoplasms / radiography. Melanoma / pathology. Melanoma / radiography
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Rare Diseases / pathology. Rare Diseases / radiography

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  • (PMID = 15986290.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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37. Matusiak L, Bieniek A, Wozniak Z, Szepietowski JC: Amelanotic malignant melanoma in an acral location. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Jun;17(2):72-4
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  • [Title] Amelanotic malignant melanoma in an acral location.
  • We present the case of a 74-year-old white female admitted to the Department of Dermatology because of a tumor in the IV-V interdigital area of her right foot.
  • The biopsy, stained with H and E, revealed an anaplastic malignant tumor.
  • Additional immunochemical staining with Melan A allowed us to make the final diagnosis: amelanotic malignant melanoma (MM).
  • The melanoma was removed by amputation of digits IV and V, with partial removal of the metatarsal bones (Clark degree 5, Breslow thickness 9 mm).
  • [MeSH-major] Foot Dermatoses / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 18709293.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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38. Wu CY, Gao HW, Chiang CP: Malignant amelanotic melanoma developing from an intradermal naevus in a patient with oculocutaneous albinism. Clin Exp Dermatol; 2009 Dec;34(8):e590-3
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  • [Title] Malignant amelanotic melanoma developing from an intradermal naevus in a patient with oculocutaneous albinism.
  • Histopathologically, the tumour revealed benign naevus cells in the upper dermis and atypical malignant tumour cells in the deeper dermis.
  • Amelanotic malignant melanoma (MM) originating from a pre-existing intradermal naevus was diagnosed.
  • [MeSH-major] Albinism, Oculocutaneous / pathology. Melanoma / pathology. Nevus, Intradermal / pathology. Skin Neoplasms / pathology


39. Hargis AM, Baldessari AE, Walder EJ: Intraepidermal adenocarcinoma in the perianal skin of two cats, a condition resembling human extramammary Paget's disease. Vet Dermatol; 2008 Feb;19(1):31-7
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  • [Title] Intraepidermal adenocarcinoma in the perianal skin of two cats, a condition resembling human extramammary Paget's disease.
  • In humans, mammary and extramammary Paget's disease is an uncommon to rare manifestation of intraepidermal adenocarcinoma arising from simple epithelium, usually glandular in origin.
  • This report describes two cats with lesions in perianal skin consisting of atypical intraepidermal neoplastic cells.
  • Differential diagnoses included intraepidermal adenocarcinoma, in situ squamous or basal cell carcinoma, junctional amelanotic melanoma, and epitheliotropic tumours of histiocytic or lymphocytic origin.
  • In one cat the clinical lesions consisted of a pruritic erythematous eruption surrounding the anus.
  • The clinical features, histological appearance, and immunohistochemical staining of the skin lesions were consistent with those described for human perianal extramammary Paget's disease.
  • [MeSH-major] Adenocarcinoma / veterinary. Cat Diseases / diagnosis. Perineum / pathology. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Diagnosis, Differential. Female. Humans. Paget Disease, Extramammary

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  • (PMID = 18177290.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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40. Becerra EM, Saornil MA, Blanco G, Méndez MC, Muiños Y, Esteban MR: Cavitary choroidal melanoma. Can J Ophthalmol; 2005 Oct;40(5):619-22
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  • [Title] Cavitary choroidal melanoma.
  • CASE REPORT: We report an unusual case of cavitary choroidal melanoma.
  • The results of ultrasonography, magnetic resonance imaging, computed tomography, and immunohistochemical studies are presented for a 38-year-old woman who developed an amelanotic tumor in the posterior choroid.
  • Enucleation was performed and histopathologic examination showed a choroidal melanoma of spindle cell type, with intratumoral cavitations lined by flattened tumor cells.
  • Uveal melanoma should be included in the differential diagnosis of choroidal cavitary lesions.
  • As far as we know, this is the second documented clinicopathologic correlation of a cavitary choroidal melanoma.

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  • (PMID = 16391628.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / Vimentin
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41. Chun JK, Singer E, Kong A, Phelps R, Weltz C: Desmoplastic amelanotic melanoma in an irradiated burn scar. Dermatol Surg; 2006 Jan;32(1):161-4
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  • [Title] Desmoplastic amelanotic melanoma in an irradiated burn scar.
  • [MeSH-major] Burns / complications. Cicatrix / complications. Cicatrix / radiotherapy. Melanoma, Amelanotic / etiology. Skin Neoplasms / etiology

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  • (PMID = 16393619.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Camerin M, Rello S, Villanueva A, Ping X, Kenney ME, Rodgers MA, Jori G: Photothermal sensitisation as a novel therapeutic approach for tumours: studies at the cellular and animal level. Eur J Cancer; 2005 May;41(8):1203-12
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  • Irradiation of B78H1 murine amelanotic melanoma cells with 850 nm light emitted from a Ti:sapphire laser, operated in a pulsed mode at high fluence rates and in the presence of Ni(II)-octabutoxy-naphthalocyanine (NiNc), promoted a photothermally sensitised process leading to fast and irreversible cell death.
  • This resulted in the ejection of a consistent mass of cytoplasmic material from the irradiated cells that was detected by scanning electron microscopy.
  • Very similar results were obtained upon irradiation of NiNc-loaded C32 human amelanotic melanoma cells and transformed murine HT-1080 and HaCaT fibroblasts.
  • From these results, photothermal sensitisation appears to be a general phenomenon and preliminary studies with mice bearing subcutaneously transplanted amelanotic melanomas, irradiated with 850 nm light 24 h after intravenous injection of NiNc, suggest that this approach has potential for the therapy of some types of skin tumours.
  • [MeSH-major] Melanoma, Amelanotic / drug therapy. Metalloporphyrins / therapeutic use. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use

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  • (PMID = 15911245.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 91027
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Metalloporphyrins; 0 / Photosensitizing Agents; 0 / octabutoxynaphthalocyaninenickel(II)
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43. Castillo O, Frisancho O, Palomino A: [Cecal amelanotic melanoma]. Rev Gastroenterol Peru; 2010 Oct-Dec;30(4):368-71
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  • [Title] [Cecal amelanotic melanoma].
  • [Transliterated title] Melanoma amelanótico en ciego.
  • Subsequently, we confirmed the presence of red blood in stools, like enterorrhagia and underwent a colonoscopy, in which two elevated lesions were found in the cecum: a pedunculated (with active bleeding, oozing) and other sessile; both were removed. the pathology showed that corresponded to amelanotic melanoma in cecal region.
  • Physical examination revealed no malignant skin lesions.
  • We report this case, because gastrointestinal bleeding is an unusual clinical presentation of malignant melanoma.
  • [MeSH-major] Cecal Neoplasms / pathology. Melanoma / pathology

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  • (PMID = 21263766.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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44. André J, Moulonguet I, Goettmann-Bonvallot S: In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases. Arch Dermatol; 2010 Apr;146(4):418-21
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  • [Title] In situ amelanotic melanoma of the nail unit mimicking lichen planus: report of 3 cases.
  • BACKGROUND: Nail apparatus melanoma is known to be associated with a poor prognosis, mainly because of a delay in diagnosis that is made at an invasive stage.
  • This delay is particularly true in cases involving amelanotic melanoma.
  • To our knowledge, only 1 case of in situ amelanotic melanoma of the nail unit has previously been described.
  • We report 3 cases of in situ amelanotic melanoma with clinical lichenoid features.
  • OBSERVATIONS: We describe 3 cases of in situ amelanotic melanoma of the nail unit.
  • Histologic examination revealed in situ amelanotic melanoma extending from the proximal matrix up to the distal part of the nail bed.
  • CONCLUSIONS: Monodactylic lichenoid nail changes should be added to the more conventional signs of incipient nail melanoma.
  • [MeSH-major] Lichen Planus / diagnosis. Melanoma, Amelanotic / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 20404232.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Mercadier B, Hu W, Valentin S, Sassolas B: [Amelanotic malignant melanoma: about three cases]. Ann Chir Plast Esthet; 2007 Feb;52(1):68-70
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  • [Title] [Amelanotic malignant melanoma: about three cases].
  • [Transliterated title] Mélanome malin achromique : à propos de trois cas.
  • The amelanotic melanoma is a rare type of malignant melanoma.
  • The purpose of this report is to point out this aspect of melanoma, whose diagnostic delay is frequent.
  • We describe one localisation on the penis, rare in this kind of melanoma and two cases of the extremities, more frequent localization of the amelanotic melanoma.
  • The therapeutic issues and recommendation are similar to the classical pigmented malignant melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 17030390.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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46. Babilas P, Liebsch G, Schacht V, Klimant I, Wolfbeis OS, Szeimies RM, Abels C: In vivo phosphorescence imaging of pO2 using planar oxygen sensors. Microcirculation; 2005 Sep;12(6):477-87
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  • Due to intrinsically referencing via lifetime encoding there was no modification of the sensor response in vivo in the dorsal skinfold chamber model with amelanotic melanoma (A-MEL-3) in awake hamsters when compared to the in vitro calibration. pO(2) measurements over normal tissue (25.8 +/- 5.1 mm Hg) and tumor tissue (9.2 +/- 5.1 mm Hg) were in excellent agreement with previous results obtained in this model using a surface multiwire electrode.
  • [MeSH-major] Luminescent Measurements. Melanoma, Experimental / metabolism. Metalloporphyrins / analysis. Oximetry. Oxygen Consumption

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  • (PMID = 16147465.001).
  • [ISSN] 1073-9688
  • [Journal-full-title] Microcirculation (New York, N.Y. : 1994)
  • [ISO-abbreviation] Microcirculation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metalloporphyrins; 0 / Polystyrenes
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47. Fulciniti F, Ascierto PA, Simeone E, Bove P, Losito S, Russo S, Gallo MS, Greggi S: Nevoid melanoma of the vagina: report of one case diagnosed on thin layer cytological preparations. Cytojournal; 2007;4:14
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  • [Title] Nevoid melanoma of the vagina: report of one case diagnosed on thin layer cytological preparations.
  • BACKGROUND: Primary melanoma of the vagina is an extremely rare neoplasm with approximately 250 reported cases in the world literature 1234.
  • In its amelanotic variant this lesion may raise several differential diagnostic problems in cytological specimens 5.
  • The aim of this paper is to describe the cytomorphological presentation of primary vaginal melanoma on LBP since it has not previously been reported up to now, to our knowledge.
  • A cytopathological diagnosis of amelanotic melanoma was rendered.
  • CONCLUSION: amelanotic melanoma may be successfully diagnosed on LBP cytological preparations.
  • Thin layer preparations may enhance the diagnostic cytomorphological clues to its diagnosis and may permit an adequate immunocytochemical characterization of the neoplasm.

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  • [Cites] Int J Gynecol Cancer. 2004 May-Jun;14(3):553-7 [15228434.001]
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  • (PMID = 17608945.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1934920
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48. Nakahara T, Tamaki Y, Tominaga N, Ide Y, Nasu M, Ohyama A, Sato S, Ishiwata I, Ishikawa H: Novel amelanotic and melanotic cell lines NM78-AM and NM78-MM derived from a human oral malignant melanoma. Hum Cell; 2010 Feb 01;23(1):15-25
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  • [Title] Novel amelanotic and melanotic cell lines NM78-AM and NM78-MM derived from a human oral malignant melanoma.
  • Abstract Novel cell lines, designated NM78-AM and NM78-MM, have been established from a malignant melanoma of the cheek oral mucosa.
  • NM78-AM cells were spherical, grew in suspension as clusters, and produced no melanin.
  • Initially, NM78-AM cells were grown on fibroblast feeder cells or in growth media supplemented with 10% conditioned medium from fibroblasts, but eventually grew in standard growth media alone.
  • NM78-AM cells had interdigitating microvilli and formed cell clusters.
  • NM78-AM cells were slightly sensitive to actinomycin D, but not to cisplatin, irinotecan, the irinotecan metabolite SN-38, taxol, taxotere, bleomycin and methotrexate; NM78-MM cells were sensitive to cisplatin, and not to taxol, taxotere, carboplatin, and irinotecan.
  • These new cell lines, NM78-AM and NM78-MM, will be very important for the development of new chemotherapeutics for oral malignant melanoma.
  • [MeSH-major] Melanoma / pathology. Mouth Neoplasms / pathology


49. Cahill S, Cryer JR, Otter SJ, Ramesar K: An amelanotic malignant melanoma masquerading as hypergranulation tissue. Foot Ankle Surg; 2009;15(3):158-60
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  • [Title] An amelanotic malignant melanoma masquerading as hypergranulation tissue.
  • We report a case of amelanotic malignant melanoma occurring in the nail sulcus of the hallux, which on initial presentation was mistaken for hypergranulation tissue due to an in-growing toenail.
  • We highlight the importance of this differential diagnosis as such lesions can have serious sequelae.
  • [MeSH-major] Melanoma / physiopathology. Melanoma / surgery. Skin Neoplasms / physiopathology. Skin Neoplasms / surgery

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  • (PMID = 19635427.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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50. Nejc D, Piekarski J, Pasz-Walczak G, Wroński K, Pluta P, Jeziorski A: The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. Melanoma Res; 2005 Dec;15(6):565-9
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  • [Title] The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis.
  • We present the first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis.
  • Pathologic examination of the postoperative specimen revealed the presence of a very rare malignancy--amelanotic melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Penile Neoplasms / pathology

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  • (PMID = 16314746.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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51. Conforti F, Menichini F, Rigano D, Senatore F: Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes. Z Naturforsch C; 2009 Jul-Aug;64(7-8):490-4
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  • The in vitro cytotoxic activity assay against two human cancer cell lines, large lung carcinoma (CORL-23) and amelanotic melanoma (C32), showed that the most antiproliferative extract was the MeOH extract from flowers with a percentage of inhibition of 50.9 at 100 microg/ml against amelanotic melanoma cells.
  • The most antiproliferative compounds against amelanotic melanoma cells were kaempferol-3-O-beta-D-glucopyranoside and irisolidone with a percentage of inhibition of 100 and 96.6, respectively, and against large lung carcinoma cells with a percentage of inhibition of 82.1 and 84.6, respectively.
  • Significant activity on the amelanotic melanoma cell line was also showed by irigenin-7-O-beta-D-glucopyranoside, with a percentage of inhibition of 89.3.
  • The compounds isovitexin and isoorientin-6-O''-beta-D-glucopyranoside showed a selective activity against amelanotic melanoma cells with a percentage of inhibition of 83.2 and 79.8, respectively.
  • [MeSH-minor] Carcinoma, Large Cell / pathology. Cell Line, Tumor. Humans. Lung Neoplasms / pathology. Melanoma, Amelanotic / pathology. Plant Extracts / chemistry. Polyphenols

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  • (PMID = 19791498.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Flavonoids; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols
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52. Stringa O, Valdez R, Beguerie JR, Abbruzzese M, Lioni M, Nadales A, Iudica F, Venditti J, San Roman A: Primary amelanotic melanoma of the esophagus. Int J Dermatol; 2006 Oct;45(10):1207-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary amelanotic melanoma of the esophagus.
  • Primary melanoma of the esophagus (PME) is an uncommon malignancy with less than 250 cases reported in the literature.
  • Amelanotic PME is exceedingly rare and accounts for 10-25% of melanomas of the esophagus.
  • No skin or eye melanoma lesions were found.
  • Peritumoral lymph nodes revealed malignant invasion.
  • A diagnosis of primary amelanotic melanoma of the esophagus was made.
  • Fourteen months after diagnosis the patient developed disseminated PME.
  • [MeSH-major] Esophageal Neoplasms / pathology. Melanoma, Amelanotic / pathology


53. Graff BA, Benjaminsen IC, Melås EA, Brurberg KG, Rofstad EK: Changes in intratumor heterogeneity in blood perfusion in intradermal human melanoma xenografts during tumor growth assessed by DCE-MRI. Magn Reson Imaging; 2005 Nov;23(9):961-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Changes in intratumor heterogeneity in blood perfusion in intradermal human melanoma xenografts during tumor growth assessed by DCE-MRI.
  • The purpose of this study was to use dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to search for systematic intratumor heterogeneity in blood perfusion in human melanoma xenografts growing intradermally in BALB/c-nu/nu mice.
  • Six xenografted tumors of an amelanotic human melanoma line (A-07) were included in the study.
  • In conclusion, intradermal human melanoma xenografts show significant systematic intratumor heterogeneity in blood perfusion.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Melanoma, Experimental / blood supply. Skin Neoplasms / blood supply

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  • (PMID = 16310112.001).
  • [ISSN] 0730-725X
  • [Journal-full-title] Magnetic resonance imaging
  • [ISO-abbreviation] Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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54. Jin B, Goldsmith A, Budev H, Al-Abbadi M: Primary melanoma of the uterine cervix after supracervical hysterectomy. A case report. Acta Cytol; 2007 Jan-Feb;51(1):86-8
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  • [Title] Primary melanoma of the uterine cervix after supracervical hysterectomy. A case report.
  • BACKGROUND: Primary malignant melanomas of the uterine cervix are uncommon.
  • The dysplastic cells were amelanotic and demonstrated immunoreactivity to S-100 protein and HMB-45.
  • Diagnosis of malignant melanoma was made.
  • Residual malignant melanoma involving the ectocervical squamous mucosa was noted, but bilateral pelvic lymph nodes were negative for metastatic melanoma.
  • The patient had no prior history of cutaneous melanoma or other malignancies.
  • CONCLUSION: To our knowledge, this is the first published case report of primary melanoma of the cervix occurring after supracervical hysterectomy.
  • Although uncommon, melanoma should be considered in the differential diagnosis of high grade dysplasia.
  • [MeSH-major] Melanoma / pathology. Uterine Cervical Neoplasms / pathology


55. Blum A: [Therapy of amelanotic melanoma]. Dtsch Med Wochenschr; 2005 May 20;130(20):1277
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Therapy of amelanotic melanoma].
  • [MeSH-major] Melanoma, Amelanotic / therapy. Skin Neoplasms / therapy
  • [MeSH-minor] Diagnosis, Differential. Humans. Sentinel Lymph Node Biopsy. Skin / pathology. Time Factors

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  • (PMID = 15889328.001).
  • [ISSN] 0012-0472
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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56. Andonegui-Navarro J, Aranguren-Laflin M, Aliseda-Pérez-de-Madrid D, Rebollo-Aguayo A: [Asymptomatic vasoproliferative retinal tumor]. Arch Soc Esp Oftalmol; 2005 Nov;80(11):675-7
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  • [Transliterated title] Tumor vasoproliferativo de la retina asintomático.
  • The differential diagnoses needing consideration are a retinal hemangioma associated with von Hippel-Lindau disease, an amelanotic choroidal melanoma and an ocular metastasis from a tumor elsewhere.

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  • (PMID = 16311959.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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57. González-García R, Naval-Gías L, Martos PL, Nam-Cha SH, Rodríguez-Campo FJ, Muñoz-Guerra MF, Sastre-Pérez J: Melanoma of the oral mucosa. Clinical cases and review of the literature. Med Oral Patol Oral Cir Bucal; 2005 May-Jul;10(3):264-71
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  • [Title] Melanoma of the oral mucosa. Clinical cases and review of the literature.
  • The appearance of primary melanomas of the oral mucosa is uncommon.
  • The difficulty to obtain free surgical margins, the elevated tendency to invade in depth and the early haematogenous metastasis have been referred as features which may explain its bad prognosis, even in comparison with cutaneous melanoma.
  • Due to the absence of any treatment modality which may substantially increase long-term survival, we suggest the use of resective surgery with wide margins and early diagnosis by means of biopsy for suspicious melanotic-pigmented lesions.
  • In this work we present 2 new cases of primary melanoma of the oral mucosa, with a follow-up period of 72 and 12 months respectively, and we make a review of the literature in relation with this rare entity.
  • [MeSH-major] Gingival Neoplasms / pathology. Melanoma / pathology. Mouth Mucosa / pathology. Palatal Neoplasms / pathology
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Immunohistochemistry. Melanoma, Amelanotic / pathology. Melanoma, Amelanotic / surgery. Middle Aged. Prognosis

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  • (PMID = 15876972.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 24
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58. Menichini F, Tundis R, Loizzo MR, Bonesi M, Provenzano E, de Cindio B, Menichini F: In vitro photo-induced cytotoxic activity of Citrus bergamia and C. medica L. cv. Diamante peel essential oils and identified active coumarins. Pharm Biol; 2010 Sep;48(9):1059-65
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  • In order to evaluate the cytotoxic activity two melanoma models, such as amelanotic melanoma C32 and malignant melanoma A375, were used.
  • This phototoxicity may be considered as a treatment option in some cases of lentigo maligna or lentigo maligna melanoma.
  • [MeSH-minor] Cell Line, Tumor. Cell Survival / drug effects. Cell Survival / radiation effects. Drug Discovery. Drug Evaluation, Preclinical. Gas Chromatography-Mass Spectrometry. Humans. Inhibitory Concentration 50. Melanoma / drug therapy. Melanoma, Amelanotic / drug therapy. Methoxsalen / analogs & derivatives. Methoxsalen / analysis. Methoxsalen / chemistry. Methoxsalen / pharmacology. Methoxsalen / radiation effects. Photochemotherapy. Phytotherapy. Time Factors. Ultraviolet Rays

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  • (PMID = 20690896.001).
  • [ISSN] 1744-5116
  • [Journal-full-title] Pharmaceutical biology
  • [ISO-abbreviation] Pharm Biol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Coumarins; 0 / Oils, Volatile; 4FVK84C92X / 5-methoxypsoralen; JWE1QQ247N / 5,7-dimethoxycoumarin; U4VJ29L7BQ / Methoxsalen
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59. Latendresse JR, Muskhelishvili L, Warbritton A, Tolleson WH: Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice. Toxicol Pathol; 2007 Oct;35(6):827-32
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  • [Title] Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice.
  • Uveal melanoma (UM) is uncommon among wild type mice.
  • Efforts to develop transgenic mice to study this disease have resulted in pigmented tumors derived from the retinal pigment epithelium (RPE) or mixed tumors of RPE and UM complicating the study of UM specifically.
  • Reported here are two early stage intraocular amelanotic melanomas discovered in 2 Tyr-HRAS+ Ink4a/Arf heterozygous (1 normal CKDN2A allele) transgenic FVB/n mice.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Disease Models, Animal. Genes, ras. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / genetics. Uveal Neoplasms / pathology

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  • (PMID = 17987514.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; EC 1.14.18.1 / Monophenol Monooxygenase
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60. Arndt S, Echternach M, Aschendorff A, Schipper J, Maier W: [Malignant rhino- and otobasal mucosal melanomas--therapy and outcome]. Laryngorhinootologie; 2008 Jun;87(6):412-6
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  • [Title] [Malignant rhino- and otobasal mucosal melanomas--therapy and outcome].
  • BACKGROUND: Malignant melanoma of the rhinobasal mucosa is very rare and makes up less than one percent of all malignant melanomas.
  • MATERIALS AND METHODS: In a retrospective quality assessment, we analysed the charts of fifteen consecutive patients suffering from malignant melanoma of the skull base who where treated in our department since 1993.
  • Thus, melanoma was an accidental finding of a biopsy or sinus surgery in most patients, including all cases with amelanotic melanoma.
  • In these patients the disease specific survival was slightly better than in patients treated with surgery only.
  • [MeSH-major] Melanoma / surgery. Nose Neoplasms / surgery. Palatal Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Interferon-alpha / therapeutic use. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Orbit Evisceration. Palliative Care. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis

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  • (PMID = 18506652.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Interferon-alpha
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61. Russo A, Coupland SE, O'Keefe M, Damato BE: Choroidal melanoma in a 7-year-old child treated by trans-scleral local resection. Graefes Arch Clin Exp Ophthalmol; 2010 May;248(5):747-9
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  • [Title] Choroidal melanoma in a 7-year-old child treated by trans-scleral local resection.
  • PURPOSE: To report a choroidal melanoma in a 7-year-old child treated by trans-scleral local resection and adjuvant brachytherapy with a family history of neurofibromatosis type I (NF1) and cutaneous melanoma.
  • PATIENT AND METHODS: A 7-year-old child was referred for treatment of a choroidal tumor in her left eye with a differential diagnosis of melanoma, neurilemmoma, leiomyoma, and neurofibroma.
  • RESULTS: Histopathology and immunohistochemistry of the specimen diagnosed an amelanotic melanoma of spindle cell type, with a moderately high number of mitoses (7/40 HPF).
  • [MeSH-major] Choroid Neoplasms / surgery. Melanoma / surgery. Ophthalmologic Surgical Procedures

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  • [Cites] Acta Ophthalmol (Copenh). 1970;48(6):1113-28 [5537253.001]
  • [Cites] Ann Surg. 1972 Jan;175(1):86-104 [4621893.001]
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  • (PMID = 20143236.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Ruthenium Radioisotopes
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62. Inoue T, Misago N, Narisawa Y: Metastatic myxoid melanoma with partial regression of the primary lesion. J Cutan Pathol; 2007 Jun;34(6):508-12
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  • [Title] Metastatic myxoid melanoma with partial regression of the primary lesion.
  • Myxoid melanoma is a rare variant of malignant melanoma.
  • The diagnostic problems are obviously increased when it presents as amelanotic metastasis in a lymph node.
  • In the pigmented lesion of the right forearm, there were small clusters of tumor cells with melanin granules, suggesting malignant melanoma.
  • In the present case, myxoid metastasis occurred with the partial spontaneous disappearance of the primary nonmyxoid malignant melanoma.
  • [MeSH-major] Melanoma / secondary. Mucus / metabolism. Neoplasm Regression, Spontaneous. Skin Neoplasms / pathology

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  • (PMID = 17518782.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Melanins
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63. Stroh C, Manger T: [Primary amelanotic anorectal melanoma--a case report]. Zentralbl Chir; 2007 Dec;132(6):560-3
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  • [Title] [Primary amelanotic anorectal melanoma--a case report].
  • [Transliterated title] Das primäre amelanotische Melanom des Rektums - Ein Fallbericht.
  • BACKGROUND: The amelanotic melanoma of the rectal mucosa is very rare with an unfavourable prognosis.
  • Therefore transrectal ultrasound is of major importance in the preoperative staging and postoperative follow-up especially in diagnosis of local recurrence by using the ultrasound-guided, transrectal aspiration.
  • METHODS: In literature 5 cases of amelanotic malignant melanoma were reported.
  • The overall survival time is 10 months after diagnosis.
  • RESULTS: We report about a 55-year-old female patient with an amelanotic melanoma of rectal mucosa.
  • The patient died 36 months after diagnosis.
  • CONCLUSION: The prognosis of primary malignant anorectal melanoma is poor, irrespective of surgical treatment.
  • Wide local resection is the first choice for primary anorectal melanoma.
  • Chemotherapy, radiotherapy and immunotherapy should be considered in the treatment of anorectal melanoma to influence the overall survival.
  • [MeSH-major] Melanoma, Amelanotic / surgery. Rectal Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. Disease Progression. Endosonography. Fatal Outcome. Female. Follow-Up Studies. Humans. Intestinal Mucosa / pathology. Intestinal Mucosa / surgery. Intestinal Mucosa / ultrasonography. Lymph Node Excision. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Neoplasm Recurrence, Local / ultrasonography. Neoplasm Staging. Palliative Care. Proctoscopy. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 18098086.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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64. Bongiorno MR, Lodato G, Affronti A, Aragona F, Aricò M: Amelanotic conjunctival melanoma. Cutis; 2006 Jun;77(6):377-81
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  • [Title] Amelanotic conjunctival melanoma.
  • Conjunctival melanoma is a rare condition of the eye pigment predominantly affecting white adults.
  • We describe a 32-year-old white man with an amelanotic malignant melanoma of the conjunctiva that is not associated with primary acquired melanosis (PAM) or melanocytic nevus.
  • HMB45 protein was highly positive in the melanoma cells.
  • The de novo amelanotic malignant melanoma of the conjunctiva we describe is an extremely uncommon tumor mainly affecting white adults.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / pathology. Melanoma, Amelanotic / pathology

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  • (PMID = 16838771.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Sbai MA, Boussen M, Mankai I, Souissi M, Day SC, Korbi A, Tebib M: [Amelanotic malignant melanoma of the great toe]. Tunis Med; 2010 Feb;88(2):130-1
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  • [Title] [Amelanotic malignant melanoma of the great toe].
  • [Transliterated title] Mélanome malin achromique de l'hallux.
  • [MeSH-major] Hallux / surgery. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 20415177.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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66. Lorentzen HF, Weismann K, Rossen K, Klem Thomsen H: Poppyfield bleeding: a new dermatoscopic sign and its histopathological background. Acta Derm Venereol; 2007;87(2):149-51
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  • Dermatoscopy increases the accuracy of diagnosis of melanoma.
  • An atypical vascular pattern may be an indicator of cutaneous malignant melanoma (CMM).
  • Age of the patients and Breslow thickness of the cutaneous malignant melanoma were similar in the two groups.
  • It may be a dermatoscopic reflection of increased vascular density described in primary CMMs compared with adjacent skin and may also reflect the presence of primitive vessels in CMMs displaying increased fragility.
  • [MeSH-major] Dermoscopy / methods. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Humans. Melanoma, Amelanotic / blood supply. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology

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  • (PMID = 17340022.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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67. Knaggs S, Malkin H, Osborn HM, Williams NA, Yaqoob P: New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT). Org Biomol Chem; 2005 Nov 7;3(21):4002-10
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  • Finally, HPLC studies and preliminary cytotoxicity studies in a melanotic and an amelanotic cell line, that illustrate the feasibility of the approach, are presented.
  • [MeSH-major] Drug Delivery Systems / methods. Melanocytes / drug effects. Melanoma / drug therapy. Prodrugs / chemical synthesis

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  • (PMID = 16240021.001).
  • [ISSN] 1477-0520
  • [Journal-full-title] Organic & biomolecular chemistry
  • [ISO-abbreviation] Org. Biomol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminophenols; 0 / Prodrugs; 38411-80-2 / 6-aminodopamine; 8W8T17847W / Urea; EC 1.14.18.1 / Monophenol Monooxygenase; R7P8FRP05V / 4-aminophenol; VTD58H1Z2X / Dopamine
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68. García-Fernández AJ, Rodríguez RA, Pérez-Pertejo Y, Balaña-Fouce R: Characterization of putrescine uptake in hamster amelanocytic melanoma AMEL-3 cells. Mol Cells; 2005 Aug 31;20(1):127-35
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  • [Title] Characterization of putrescine uptake in hamster amelanocytic melanoma AMEL-3 cells.
  • The uptake of putrescine, spermidine and spermine by Fortner's hamster amelanocytic melanoma AMEL-3 cells was observed in this study to be time-dependent, temperature-sensitive, pH-dependent and saturable.
  • [MeSH-minor] Amidines / pharmacology. Animals. Biological Transport / drug effects. Cell Cycle / drug effects. Cricetinae. Dose-Response Relationship, Drug. Down-Regulation / drug effects. Ethylmaleimide / pharmacology. Hydrogen-Ion Concentration. Kinetics. Melanoma, Amelanotic. Mesocricetus. Skin Neoplasms / metabolism. Spermidine / metabolism. Spermine / metabolism. Sulfhydryl Reagents / pharmacology. Time Factors. Tumor Cells, Cultured

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  • (PMID = 16258251.001).
  • [ISSN] 1016-8478
  • [Journal-full-title] Molecules and cells
  • [ISO-abbreviation] Mol. Cells
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Amidines; 0 / Sulfhydryl Reagents; 2FZ7Y3VOQX / Spermine; O3C74ACM9V / Ethylmaleimide; U87FK77H25 / Spermidine; V10TVZ52E4 / Putrescine
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69. Traynor NJ, McKenzie RC, Beckett GJ, Gibbs NK: Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation. Photodermatol Photoimmunol Photomed; 2006 Dec;22(6):297-303
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  • BACKGROUND: Ultraviolet (UV) radiation damages the cellular DNA of skin cells.
  • METHODS: We examined whether selenomethionine could protect human skin cells from UV radiation-induced p53 transactivation, using a pRGCDeltafos-lacZ p53-dependent reporter construct stably transfected in an amelanotic melanoma cell line (Arn-8) which expresses wild-type p53.
  • [MeSH-major] Radiation-Protective Agents / pharmacology. Selenomethionine / pharmacology. Skin / drug effects. Skin / radiation effects. Ultraviolet Rays

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  • (PMID = 17100737.001).
  • [ISSN] 0905-4383
  • [Journal-full-title] Photodermatology, photoimmunology & photomedicine
  • [ISO-abbreviation] Photodermatol Photoimmunol Photomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Radiation-Protective Agents; 0 / Tumor Suppressor Protein p53; 964MRK2PEL / Selenomethionine
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70. Mondin V, Rinaldo A, Shaha A, Cureoglu S, Devaney KO, Suárez C, Ferlito A: Malignant melanoma of the auricle. Acta Otolaryngol; 2005 Nov;125(11):1140-4
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  • [Title] Malignant melanoma of the auricle.
  • Malignant melanomas are found in a variety of locations, ranging from sun-exposed skin to the nasal cavity and paranasal sinuses.
  • Melanomas arising in the head and neck region comprise some 20% of all melanomas; of these, 7-15% occur in the vicinity of the external ear (most often on the helix).
  • Auricular melanomas, like those arising elsewhere, are rare in childhood and are most often first diagnosed in men in their 50s.
  • Melanomas of the external ear may present as flat pigmented lesions or as raised mass lesions; amelanotic (non-pigmented) variants exist as well.
  • Auricular melanomas are frequently recognized pathologically as either superficial spreading melanomas or nodular melanomas.
  • Key pathologic prognostic features of auricular melanomas include the histological subtype, tumor thickness, level of invasion and presence of ulceration.
  • [MeSH-major] Ear Neoplasms / diagnosis. Ear, External. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16353384.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 42
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71. Michard Q, Commo S, Belaidi JP, Alleaume AM, Michelet JF, Daronnat E, Eilstein J, Duche D, Marrot L, Bernard BA: TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress. Free Radic Biol Med; 2008 Mar 15;44(6):1023-31
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  • Here we studied a possible role of TRP-2 in the oxidative stress response in the amelanotic WM35 melanoma cell line.
  • [MeSH-major] Epithelial Cells / metabolism. Intramolecular Oxidoreductases / metabolism. Melanoma / metabolism. Oxidative Stress / physiology

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  • (PMID = 18206123.001).
  • [ISSN] 0891-5849
  • [Journal-full-title] Free radical biology & medicine
  • [ISO-abbreviation] Free Radic. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.3.12 / dopachrome isomerase; GAN16C9B8O / Glutathione
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72. Vad NM, Yount G, Moridani MY: Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines. Melanoma Res; 2008 Dec;18(6):386-99
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  • [Title] Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
  • In the current work, we investigated the biochemical toxicity of acetylsalicylic acid (ASA; Aspirin) in human melanoma cell lines using tyrosinase enzyme as a molecular cancer therapeutic target.
  • ASA at 100 micromol/l was selectively toxic toward human melanocytic SK-MEL-28, MeWo, and SK-MEL-5 and murine melanocytic B16-F0 and B16-F10 melanoma cell lines.
  • However, ASA was not significantly toxic to human amelanotic C32 melanoma cell line, which does not express tyrosinase enzyme, and human nonmelanoma BJ, SW-620, Saos, and PC-3 cells.
  • Dicoumarol, a diaphorase inhibitor, and 1-bromoheptane, a GSH depleting agent, increased ASA toxicity toward SK-MEL-28 cells indicating quinone formation and intracellular GSH depletion played important mechanistic roles in ASA-induced melanoma toxicity.
  • ASA led to significant intracellular GSH depletion in melanocytic SK-MEL-28 melanoma cells but not in amelanotic C32 melanoma cells.
  • ASA also led to significant reactive oxygen species (ROS) formation in melanocytic SK-MEL-28 melanoma cells but not in amelanotic C32 melanoma cells.
  • Our investigation suggests that quinone species, intracellular GSH depletion, ROS formation, and mitochondrial toxicity significantly contributed toward ASA selective toxicity in melanocytic SK-MEL-28 melanoma cells.
  • [MeSH-major] Anti-Inflammatory Agents, Non-Steroidal / pharmacology. Antineoplastic Agents / pharmacology. Aspirin / pharmacology. Melanocytes / drug effects. Melanoma / metabolism. Skin Neoplasms / metabolism

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  • (PMID = 18971789.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R15CA122044-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Antineoplastic Agents; 0 / Benzoquinones; 0 / Reactive Oxygen Species; 3T006GV98U / benzoquinone; EC 1.14.18.1 / Monophenol Monooxygenase; GAN16C9B8O / Glutathione; R16CO5Y76E / Aspirin
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73. Betti R, Menni S, Crosti C: A reddish nodule on the glans penis--quiz case. Arch Dermatol; 2006 Apr;142(4):515-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Male. Middle Aged. Neoplasm Metastasis. Penis / pathology

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  • (PMID = 16618877.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Schöttler L, Körber A, Denisjuk N, Freise J, Dissemond J: [Malignant melanoma masquerading as a neurotrophic ulcer]. Med Klin (Munich); 2009 Sep 15;104(9):723-6
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  • [Title] [Malignant melanoma masquerading as a neurotrophic ulcer].
  • [Transliterated title] Malignes Melanom imitiert ein neurotrophes Ulkus.
  • After the initial examination in the outpatient wound healing clinic, a malignant melanoma already showing invasive growth with a penetration depth of 4.6 mm was detected in a biopsy.
  • After diagnosis and exclusion of metastases, a phase-adapted complete excision was carried out.
  • CONCLUSION: Malignant melanoma is a primary cutaneous malignant tumor.
  • Its thickness at the time of the initial diagnosis is crucial to the prognosis.
  • Ulcerated and amelanotic melanomas still present a considerable clinical challenge due to the likelihood of being mistaken for benign diseases and the occurrence of filiae when diagnosis is made too late.
  • This case report demonstrates the importance of differential diagnostic consideration of neoplasias, for example malignant melanoma, in cases of unclear, therapy-refractory wounds and discusses the relevant aspects in avoiding an unnecessary prolongation of diagnostics.
  • [MeSH-major] Diabetic Foot / diagnosis. Diabetic Nephropathies / diagnosis. Heel. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Interferons / therapeutic use. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Sentinel Lymph Node Biopsy

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  • [Cites] Br J Dermatol. 2002 Apr;146 Suppl 61:24-30 [11966729.001]
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  • [Cites] Cancer. 2005 Feb 1;103(3):616-24 [15630700.001]
  • (PMID = 19779677.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 9008-11-1 / Interferons
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75. Rigano D, Conforti F, Formisano C, Menichini F, Senatore F: Comparative free radical scavenging potential and cytotoxicity of different extracts from Iris pseudopumila Tineo flowers and rhizomes. Nat Prod Res; 2009;23(1):17-25
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  • The chloroform extract from rhizomes demonstrated a good cytotoxic activity against amelanotic melanoma cancer cell line (C32) with an IC(50) of 57 microg mL(-1).

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  • (PMID = 19140069.001).
  • [ISSN] 1478-6427
  • [Journal-full-title] Natural product research
  • [ISO-abbreviation] Nat. Prod. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Biphenyl Compounds; 0 / Free Radical Scavengers; 0 / Picrates; 0 / Plant Extracts; 1898-66-4 / 2,2-diphenyl-1-picrylhydrazyl
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76. Schobert CS, Labelle P, Dubielzig RR: Feline conjunctival melanoma: histopathological characteristics and clinical outcomes. Vet Ophthalmol; 2010 Jan;13(1):43-6
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  • [Title] Feline conjunctival melanoma: histopathological characteristics and clinical outcomes.
  • PURPOSE: We report on the histopathology and clinical features of 21 cases of feline conjunctival melanoma.
  • Sixteen tumors were pigmented while five were amelanotic.
  • Survival time post-diagnosis ranged from 0.5 to 36 months.
  • CONCLUSIONS: Feline conjunctival melanoma is most frequently found on the bulbar conjunctiva, are mostly round cells and suggest that conjunctival melanoma in cats has a poorer long term prognosis than the same neoplasm in dogs.
  • [MeSH-major] Cat Diseases / pathology. Conjunctival Neoplasms / veterinary. Melanoma / veterinary

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  • (PMID = 20149175.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Vad NM, Kudugunti SK, Graber D, Bailey N, Srivenugopal K, Moridani MY: Efficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice. Int J Oncol; 2009 Jul;35(1):193-204
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  • [Title] Efficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.
  • Previously, we reported that acetaminophen (APAP) showed selective toxicity towards melanoma cell lines.
  • In the current study, we investigated further the role of tyrosinase in APAP toxicity in SK-MEL-28 melanoma cells in the presence of a short hairpin RNA (shRNA) plasmid, silencing tyrosinase gene.
  • It was also found that APAP selectively caused escalation in reactive oxygen species (ROS) formation and intracellular GSH (ICG) depletion in melanocytic human SK-MEL-28 and murine B16-F0 melanoma cells that express functional tyrosinase whereas it lacked significant effects on ROS formation and ICG in amelanotic C32 melanoma cells that do not express functional tyrosinase.
  • These findings suggest that tyrosinase plays a major role in APAP selective induced toxicity in melanocytic melanoma cell lines.
  • Furthermore, the in vivo efficacy and toxicity of APAP in the skin melanoma tumor model in mice was investigated.
  • Mice receiving APAP at 60, 80, 100 and 300 mg/kg/day, day 7 through 13 post melanoma cell inoculation demonstrated tumor size growth inhibition by 7+/-14, 30+/-17, 45+/-11 and 57+/-3%, respectively.
  • Mice receiving APAP day 1 through 13 post melanoma cell inoculation showed tumor size growth inhibition by 11+/-7, 33+/-9, 36+/-20 and 44+/-28%, respectively.
  • [MeSH-major] Acetaminophen / pharmacology. Antineoplastic Agents / pharmacology. Melanoma, Experimental / drug therapy. Skin Neoplasms / drug therapy

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  • (PMID = 19513568.001).
  • [ISSN] 1019-6439
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1R15CA122044-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Reactive Oxygen Species; 0 / Sulfhydryl Compounds; 0U46U6E8UK / NAD; 362O9ITL9D / Acetaminophen; EC 1.14.18.1 / Monophenol Monooxygenase; ER0CTH01H9 / Phenacetin; GAN16C9B8O / Glutathione; PQ6CK8PD0R / Ascorbic Acid
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78. Altamura D, Piccolo D, Lozzi GP, Peris K: Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma. J Am Acad Dermatol; 2005 Sep;53(3):539-41
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  • [Title] Eccrine poroma in an unusual site: a clinical and dermoscopic simulator of amelanotic melanoma.
  • [MeSH-major] Acrospiroma / diagnosis. Dermoscopy. Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • (PMID = 16112378.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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79. Ji Q, Gondek D, Hurwitz AA: Provision of granulocyte-macrophage colony-stimulating factor converts an autoimmune response to a self-antigen into an antitumor response. J Immunol; 2005 Aug 1;175(3):1456-63
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  • In this study, we studied immune responses against the murine B16 melanoma using a tyrosinase-related protein 2 (TRP-2) peptide as a model tumor/self-Ag.
  • The addition of an irradiated GM-CSF-expressing, amelanotic tumor cell vaccine significantly delayed s.c.
  • [MeSH-major] Autoantigens / immunology. Granulocyte-Macrophage Colony-Stimulating Factor / physiology. Melanoma, Experimental / immunology. Melanoma, Experimental / prevention & control

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  • (PMID = 16034082.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Blocking; 0 / Antigens, CD; 0 / Antigens, Differentiation; 0 / Antigens, Neoplasm; 0 / Autoantigens; 0 / CTLA-4 Antigen; 0 / Cancer Vaccines; 0 / Ctla4 protein, mouse; 0 / Epitopes, T-Lymphocyte; 0 / Membrane Proteins; 0 / Peptide Fragments; 0 / Trp2 protein, vertebrate; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.3.12 / dopachrome isomerase
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80. Schallreuter KU, Hasse S, Rokos H, Chavan B, Shalbaf M, Spencer JD, Wood JM: Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells. Exp Dermatol; 2009 Aug;18(8):680-8
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  • [Title] Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells.
  • For this purpose, we utilized human primary melanocyte cell cultures and human melanoma cells with different pigmentation capacity applying immunofluorescence, RT-PCR, Western blotting and determination of melanin content.
  • Moreover, we show that cholesterol increases melanogenesis in these cells and in human melanoma cells of intermediate pigmentation (FM55) in a time- and dose-dependent manner.
  • Cellular cholesterol levels in melanoma cells with different pigmentation patterns, epidermal melanocytes and keratinocytes do not differ except in the amelanotic (FM3) melanoma cell line.
  • [MeSH-major] Cholesterol / metabolism. Epidermis / cytology. Melanocytes / cytology. Melanoma / pathology

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  • (PMID = 19469904.001).
  • [ISSN] 1600-0625
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apolipoprotein B-100; 0 / Receptors, Estrogen; 0 / Receptors, LDL; 1406-16-2 / Vitamin D; 97C5T2UQ7J / Cholesterol; E0399OZS9N / Cyclic AMP
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81. Vazquez-Lopez F, Mas-Vidal A, Sanchez-Martin J, Pérez-Oliva N, Argenziano G: Perifollicular white halo: a dermoscopic subpattern of melanocytic and nonmelanocytic skin lesions. Arch Dermatol; 2009 Nov;145(11):1350
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  • [Title] Perifollicular white halo: a dermoscopic subpattern of melanocytic and nonmelanocytic skin lesions.
  • [MeSH-major] Dermoscopy / methods. Melanoma, Amelanotic / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Biopsy, Needle. Diagnosis, Differential. Hair Follicle / pathology. Humans. Immunohistochemistry

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  • (PMID = 19917980.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Yoon TY, Kim HJ, Kim JW, Kim MK, Lee JY: Bowen's disease concealed by purpura. J Dermatol; 2007 Jan;34(1):65-7
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  • [Title] Bowen's disease concealed by purpura.
  • Bowen's disease (BD) is a squamous cell carcinoma in situ characterized by a well-demarcated scaly erythematous thin plaque with an irregular outline.
  • Clinically, BD is frequently misdiagnosed as superficial basal cell carcinoma, patches of dermatitis, psoriasis, lichen planus, actinic keratosis, benign lichenoid keratosis, irritated seborrheic keratosis, viral warts, amelanotic melanoma or melanoma.
  • However, angiosarcoma has not usually been mentioned in the differential diagnosis of BD before.
  • [MeSH-major] Bowen's Disease / complications. Purpura / complications. Scalp. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 17204105.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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83. Conforti F, Ioele G, Statti GA, Marrelli M, Ragno G, Menichini F: Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem Toxicol; 2008 Oct;46(10):3325-32
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  • Sixteen edible plants from Southern Italy were evaluated for their in vitro antiproliferative properties, using the sulforodamine B (SRB) assay, on four human cancer cell lines: breast cancer MCF-7, prostate cancer LNCaP, amelanotic melanoma C32 and renal adenocarcinoma ACHN.
  • Mentha aquatica showed a selective antiproliferative activity on breast cancer while significant activity was exerted by Cichorium intybus on melanoma.

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  • (PMID = 18768152.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Plant Extracts
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84. Blum A: 1st congress of the International Dermoscopy Society. Dermatology; 2006;213(4):337-40
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  • [MeSH-major] Dermoscopy. Skin Neoplasms / diagnosis
  • [MeSH-minor] Carcinoma, Basal Cell / diagnosis. Europe. Humans. Melanoma / diagnosis. Melanoma, Amelanotic / diagnosis. Nevus / diagnosis. Societies, Medical

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  • (PMID = 17135742.001).
  • [ISSN] 1018-8665
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Switzerland
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85. Hantschke M: [Hypopigmented melanocytic tumors with spindle cells. A review]. Pathologe; 2007 Nov;28(6):403-10
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  • Hypopigmented and amelanotic blue nevi are variants of the common and cell-rich blue nevus with an enhanced difficulty to make a correct diagnosis due to the lack of pigment.
  • All of the above benign melanocytic tumors with proliferations of hypopigmented spindle cells can more or less show aspects of desmoplastic melanoma.
  • The differential diagnosis of these entities demands a combination of clinical and histological parameters as well as supporting immunostaining.
  • Regarding desmoplastic melanoma, diagnoses frequently made are benign spindle cell neoplasms, scar or unspecific inflammatory condition.
  • As the histological aspects can be so misleading, attention is necessary in order to make the correct diagnosis.
  • Particular care must be taken to rule out desmoplastic melanoma in the case of spindle cell proliferations, a cicatricial or inflammatory process in the classical settings of face, volar skin, or mucous membranes.
  • The spindle cell melanoma must be distinguished from other types of malignant spindle cell neoplasms, which can involve the skin.
  • The differential diagnosis with such tumors is entrusted mainly to immunostaining.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology

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  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
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86. Koszałka P, Szmit E, Myśliwski A, Bigda J: Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters. Arch Immunol Ther Exp (Warsz); 2007 Jul-Aug;55(4):267-79
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  • [Title] Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters.
  • MATERIALS AND METHODS: The effects of intratumoral injection of rat TNF into hamsters bearing Bomirski Ab amelanotic melanoma, a fast growing tumor of high metastatic potential, were tested.
  • In vitro assays indicated a direct cytotoxic effect of TNF against Ab melanoma cells, most probably as an outcome of apoptosis.
  • Intratumoral application of TNF also caused some modulation of cytokine response in melanoma-bearing hamsters as evidenced by increased levels of IL-6 in blood serum.
  • CONCLUSIONS: This study established Bomirski Ab melanoma as a useful model for complex analysis of the anti-tumor activity of TNF.
  • [MeSH-major] Angiogenesis Inhibitors / metabolism. Melanoma, Experimental / metabolism. Neovascularization, Pathologic / metabolism. Recombinant Proteins / metabolism. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17659374.001).
  • [ISSN] 0004-069X
  • [Journal-full-title] Archivum immunologiae et therapiae experimentalis
  • [ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Cyclohexanes; 0 / Interleukin-6; 0 / Recombinant Proteins; 0 / Sesquiterpenes; 0 / Tumor Necrosis Factor-alpha; 129298-91-5 / O-(chloroacetylcarbamoyl)fumagillol
  • [Other-IDs] NLM/ PMC2766459
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87. Bonesi M, Tundis R, Deguin B, Loizzo MR, Menichini F, Tillequin F, Menichini F: In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. Bioorg Med Chem Lett; 2008 Oct 15;18(20):5431-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The effect of novel pectolinarigenin derivatives bearing a dialkylaminoalkyl substituent at O-7 on cell proliferation was evaluated in vitro in a panel of seven human cancer cell lines including renal adenocarcinoma ACHN, amelanotic melanoma C32, colorectal adenocarcinoma Caco-2, lung large cell carcinoma COR-L23, malignant melanoma A375, lung carcinoma A549 and hepatocellular carcinoma Huh-7D12 cell lines.
  • None of the tested compounds affected the proliferation of skin fibroblasts 142BR suggesting a selective activity against tumor cells.

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  • (PMID = 18818071.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Chromones; 0 / Flavones; 0 / Rhodamines; 0 / pectolinarigenin; 2609-88-3 / lissamine rhodamine B
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88. Patel GA, Ragi G, Krysicki J, Schwartz RA: Subungual melanoma: a deceptive disorder. Acta Dermatovenerol Croat; 2008;16(4):236-42
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  • [Title] Subungual melanoma: a deceptive disorder.
  • Subungual melanoma is an uncommon form of acral melanoma that arises within the nail bed.
  • The incidence for acral melanomas is similar worldwide, but the proportion is higher in dark-skinned individuals.
  • The subungual form represents about 2% of cutaneous non-sun induced melanomas in the western world, and up to 75% in Africans, 10% in Japanese, and 25% in the Chinese of Hong Kong.
  • Up to 33% of subungual melanomas are amelanotic.
  • Non-specific features and symptoms along with a high incidence of amelanosis often lead to delayed diagnosis, disease progression, and a poor prognosis with challenging treatment options.
  • [MeSH-major] Melanoma / diagnosis. Nail Diseases / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19111151.001).
  • [ISSN] 1330-027X
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 40
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89. Cichorek M, Kozłowska K, Bryl E: Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells. Neoplasma; 2007;54(1):29-36
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  • [Title] Mitochondrial transmembrane potential in spontaneous and camptothecin-induced apoptosis of melanotic and amelanotic melanoma cells.
  • In this work we tried to estimate the role of mitochondria in the ability of cells of two: melanotic and amelanotic transplantable melanoma lines to undergo spontaneous and camptothecin-induced apoptosis.
  • The results of our investigations showed in both transplantable melanoma cells the features indicating apoptosis: DeltaPsi changes, cytochrome c release and PARP cleavage, but the degree of observed changes depended on the phenotype of melanoma cells examined.
  • After camptothecin treatment the changes were more pronounced in the amelanotic melanoma cells- the more aggressive line.
  • [MeSH-minor] Animals. Antineoplastic Agents, Phytogenic / pharmacology. Blotting, Western. Cricetinae. Cytochromes c / secretion. Cytosol / drug effects. Cytosol / metabolism. Flow Cytometry. Male. Melanoma / metabolism. Melanoma / pathology. Melanoma / physiopathology. Mesocricetus. Poly(ADP-ribose) Polymerases / metabolism. Time Factors. Tumor Cells, Cultured

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  • (PMID = 17203890.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 9007-43-6 / Cytochromes c; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; XT3Z54Z28A / Camptothecin
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90. Ashidi JS, Houghton PJ, Hylands PJ, Efferth T: Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves. J Ethnopharmacol; 2010 Mar 24;128(2):501-12
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  • ETHNOPHARMACOLOGICAL RELEVANCE: There is only scant literature on the anticancer components of medicinal plants from Nigeria, yet traditional healers in the area under study claim to have been managing the disease in their patients with some success using the species studied.
  • Three cancer cell lines (human breast adenocarcinoma cell line MCF-7, human large cell lung carcinoma cell line COR-L23 and human amelanotic melanoma C32) and one normal cell line (normal human keratinocytes SVK-14) were used for the screening of the extracts and the fractions obtained.

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  • [Copyright] Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20064598.001).
  • [ISSN] 1872-7573
  • [Journal-full-title] Journal of ethnopharmacology
  • [ISO-abbreviation] J Ethnopharmacol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Flavanones; 0 / Sitosterols; 0 / pinostrobin; 5LI01C78DD / gamma-sitosterol; 6SMK8R7TGJ / Oleanolic Acid; KM8353IPSO / amyrin
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91. Liu W, Dowling JP, Murray WK, McArthur GA, Thompson JF, Wolfe R, Kelly JW: Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. Arch Dermatol; 2006 Dec;142(12):1551-8
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  • [Title] Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas.
  • OBJECTIVES: To investigate the spectrum of growth rates in melanomas and to identify clinical associations of rapidly growing melanomas.
  • DESIGN: Clinical interview, skin examination, and pathology review.
  • SETTING: Three tertiary melanoma referral centers and 2 private dermatology practices.
  • PATIENTS: A total of 404 consecutive patients with invasive primary cutaneous melanomas.
  • MAIN OUTCOME MEASURE: A surrogate for rate of growth in primary invasive melanoma was calculated as the ratio of Breslow thickness to time to melanoma development based on a previously reported assessment tool.
  • RESULTS: One third of the melanomas grew 0.5 mm per month or more.
  • The median monthly growth rate was 0.12 mm for superficial spreading melanomas, 0.13 mm for lentigo maligna melanomas, and 0.49 mm for nodular melanomas.
  • Rapidly growing melanomas were more often symmetrical (GMR = 2.5), elevated (GMR = 1.4), amelanotic (GMR = 1.7), regular in border (GMR = 2.5), and symptomatic (GMR = 1.7).
  • CONCLUSIONS: Rapid growth of primary cutaneous melanomas is associated with aggressive histologic features and atypical clinical features.
  • [MeSH-major] Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Risk Factors. Sex Factors. Surveys and Questionnaires


92. Ghariani N, Boussofara L, Kenani N, Ghannouchi N, Mebazaa A, Denguezli M, Belajouza C, Nouira R: Post traumatic amelanotic subungual melanoma. Dermatol Online J; 2008;14(1):13
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  • [Title] Post traumatic amelanotic subungual melanoma.
  • Subungual melanomas are rare; a delay in the diagnosis is common and is associated with advanced stage.
  • Trauma may play a role in the pathogenesis or just draw attention to a skin tumor that may be more susceptible to injury.
  • We report a case of subungual melanoma that was observed in an 86 year old man.
  • The preceding trauma history and misleading clinical appearance delayed the diagnosis slightly.
  • A direct role of the trauma in the pathogenesis of melanoma remains unclear.
  • [MeSH-major] Melanoma / pathology. Nail Diseases / pathology. Nails / injuries. Skin Neoplasms / pathology

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  • (PMID = 18319030.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. Kim SJ, Park HJ, Lee JY, Cho BK: A Case of Amelanotic Subungual Melanoma. Ann Dermatol; 2008 Mar;20(1):26-8
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  • [Title] A Case of Amelanotic Subungual Melanoma.
  • Amelanotic subungual melanoma is a rare dermatosis, and it is frequently misdiagnosed probably because of its nonspecific clinical features.
  • We herein report on a case of amelanotic subungual melanoma extended to the adjacent skin in a 36-year-old Korean woman.
  • This case is interesting in that clinically, it needed differentiation from Bowen's disease, lichen planus, sarcoidosis, etc. and very early invading features of the melanoma were observed on the histopathologic section.

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  • (PMID = 27303154.001).
  • [ISSN] 1013-9087
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC4904044
  • [Keywords] NOTNLM ; Amelanotic subungual melanoma
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94. Chetty NC, Osborne V, Harland C: Amelanotic melanoma in situ: lack of sustained response to photodynamic therapy. Clin Exp Dermatol; 2008 Mar;33(2):204-6
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  • [Title] Amelanotic melanoma in situ: lack of sustained response to photodynamic therapy.
  • [MeSH-major] Melanoma, Amelanotic / drug therapy. Neoplasm Recurrence, Local / drug therapy. Photochemotherapy. Skin Neoplasms / drug therapy

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  • (PMID = 18021273.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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95. Nihal M, Ahmad N, Mukhtar H, Wood GS: Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma. Int J Cancer; 2005 Apr 20;114(4):513-21
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  • [Title] Anti-proliferative and proapoptotic effects of (-)-epigallocatechin-3-gallate on human melanoma: possible implications for the chemoprevention of melanoma.
  • Melanoma accounts for only about 4% of all skin cancer cases but most of skin cancer-related deaths.
  • Standard systemic therapies such as interferon (IFN) have not been adequately effective in the management of melanoma.
  • Therefore, novel approaches are needed for prevention and treatment of this disease.
  • Chemoprevention by naturally occurring agents present in food and beverages has shown benefits in certain cancers including nonmelanoma skin cancers.
  • Here, employing 2 human melanoma cell lines (A-375 amelanotic malignant melanoma and Hs-294T metastatic melanoma) and normal human epidermal melanocytes (NHEM), we studied the antiproliferative effects of epigallocatechin-3-gallate (EGCG), the major polyphenolic antioxidant present in green tea.
  • EGCG treatment was found to result in a dose-dependent decrease in the viability and growth of both melanoma cell lines.
  • EGCG treatment of the melanoma cell lines resulted in decreased cell proliferation (as assessed by Ki-67 and PCNA protein levels) and induction of apoptosis (as assessed cleavage of PARP, TUNEL assay and JC-1 assay).
  • EGCG also significantly inhibited the colony formation ability of the melanoma cells studied.
  • EGCG treatment of melanoma cells resulted in a downmodulation of anti-apoptotic protein Bcl2, upregulation of proapoptotic Bax and activation of caspases -3, -7 and -9.
  • Our data suggest that EGCG causes significant induction of cell cycle arrest and apoptosis of melanoma cells that is mediated via modulations in the cki-cyclin-cdk network and Bcl2 family proteins.
  • Thus, EGCG, alone or in conjunction with current therapies, could be useful for the management of melanoma.
  • [MeSH-major] Anticarcinogenic Agents / pharmacology. Apoptosis. Catechin / analogs & derivatives. Catechin / pharmacology. Melanoma / drug therapy. Melanoma / prevention & control

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  • (PMID = 15609335.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR002136-06
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / BAX protein, human; 0 / CDKN1A protein, human; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; 8R1V1STN48 / Catechin; 9002-18-0 / Agar; BQM438CTEL / epigallocatechin gallate; EC 2.4.2.30 / Poly(ADP-ribose) Polymerases; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / CASP7 protein, human; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 7; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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96. Tolleson WH, Doss JC, Latendresse J, Warbritton AR, Melchior WB Jr, Chin L, Dubielzig RR, Albert DM: Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. Arch Ophthalmol; 2005 Aug;123(8):1088-94
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  • [Title] Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
  • OBJECTIVE: To characterize a murine model of spontaneous amelanotic melanoma arising in the uvea of transgenic mice bearing a targeted deletion of the Ink4a/Arf tumor suppressor locus (exons 2 and 3) and expressing human H-ras controlled by the human tyrosinase promoter.
  • RESULTS: Uveal melanomas were locally invasive but confined to the eye, with no evidence of metastasis.
  • The retinal pigment epithelium was intact above small melanomas, and electron microscopy of the tumors failed to show the presence of basement membrane formation or desmosomes.
  • CONCLUSION: Spontaneous uveal malignant melanomas occurring in male Tyr-RAS+ Ink4a/Arf-/- transgenic mice arise within the choroid or ciliary body and share histopathological features characteristic of human uveal melanoma.
  • CLINICAL RELEVANCE: Uveal melanoma research has benefited from xenograft models, but engineered mouse models of spontaneous uveal amelanotic melanoma will undoubtedly further our understanding of the genetic underpinning for this disease.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Gene Deletion. Genes, ras / genetics. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / genetics. Tumor Suppressor Protein p14ARF / genetics. Uveal Neoplasms / pathology
  • [MeSH-minor] Animals. Biomarkers, Tumor / analysis. Disease Models, Animal. Genotype. Male. Mice. Mice, Transgenic

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  • (PMID = 16087843.001).
  • [ISSN] 0003-9950
  • [Journal-full-title] Archives of ophthalmology (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch. Ophthalmol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 01917; United States / NCI NIH HHS / CA / R01 CA 93947
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; EC 1.14.18.1 / Monophenol Monooxygenase
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97. Sayk F, Mahnken A, Stellmacher F, Dalhoff K, Merz H: [Cancer-to-cancer metastasis: amelanotic melanoma into renal cell carcinoma]. Dtsch Med Wochenschr; 2010 Mar;135(11):507-10
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  • [Title] [Cancer-to-cancer metastasis: amelanotic melanoma into renal cell carcinoma].
  • DIAGNOSIS: The autopsy revealed that he was affected by two malignant neoplasms simultaneously: an amelanotic malignant melanoma metastasizing into a localized renal cell carcinoma.
  • This is the third reported case of a malignant melanoma as donor tumor spreading into a renal cell carcinoma.
  • The amelanotic character of the melanoma exerted a special diagnostic challenge.
  • Clinical and autopsy findings as well as the immunophenotypical features of the metastatic amelanotic melanoma (HMB-45, Melan-A/MART-1, S100) and the renal cell carcinoma are described with a review of the relevant literature.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Melanoma, Amelanotic / pathology

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 20221965.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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98. Suzuki Y, Aoyama N, Minamide J, Takata K, Ogata T: Amelanotic malignant melanoma of the esophagus: report of a patient with recurrence successfully treated with chemoendocrine therapy. Int J Clin Oncol; 2005 Jun;10(3):204-7
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  • [Title] Amelanotic malignant melanoma of the esophagus: report of a patient with recurrence successfully treated with chemoendocrine therapy.
  • We report a case of primary amelanotic malignant melanoma of the esophagus, an extremely rare disease.
  • In general, the prognosis of esophageal malignant melanoma is very poor.
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Esophageal Neoplasms / drug therapy. Melanoma / drug therapy

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  • (PMID = 15990972.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0S726V972K / Nimustine; 5J49Q6B70F / Vincristine; 77238-31-4 / Interferon-beta; 7GR28W0FJI / Dacarbazine; Q20Q21Q62J / Cisplatin
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99. Bapst JP, Froidevaux S, Calame M, Tanner H, Eberle AN: Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity. J Recept Signal Transduct Res; 2007;27(5-6):383-409
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dimeric analogs of alpha-melanocyte-stimulating hormone (alpha-MSH) labeled with radiometals are potential candidates for diagnosis and therapy of melanoma by receptor-mediated tumor targeting.
  • Both melanotic and amelanotic melanomas (over-)express the melanocortin-1 receptor (MC1-R), the target for alpha-MSH.
  • In the past, dimerized MSH analogs have been shown to display increased receptor affinity compared to monomeric MSH, offering the possibility of improving the ratio between specific uptake of radiolabeled alpha-MSH by melanoma and nonspecific uptake by the kidneys.
  • In vitro, all three peptides were more potent ligands of the mouse B16-F1 melanoma cell melanocortin-1 receptor (MC1-R) than DOTA-NAPamide, which served as standard.
  • Using human HBL melanoma cells, the binding activity of diHexa(NC-NC)-Gly-Lys(DOTA)-amide was sixfold higher than that of DOTA-NAPamide.
  • It appears that despite the higher affinity to the MC1-R of the peptide dimers and their excellent internalization in vitro, the uptake by melanoma tumors in vivo was lower, possibly because of reduced tissue penetration.
  • [MeSH-major] Heterocyclic Compounds, 1-Ring / metabolism. Melanoma, Experimental / metabolism. Oligopeptides / metabolism. alpha-MSH / analogs & derivatives

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  • (PMID = 18097939.001).
  • [ISSN] 1079-9893
  • [Journal-full-title] Journal of receptor and signal transduction research
  • [ISO-abbreviation] J. Recept. Signal Transduct. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chelating Agents; 0 / Heterocyclic Compounds, 1-Ring; 0 / Indium Radioisotopes; 0 / Oligopeptides; 581-05-5 / alpha-MSH; 60239-18-1 / 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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100. Oyamada T, Tanaka H, Park CH, Ueki H, Komiya T, Arai S: Pathology of canine oral malignant melanoma with cartilage and/or osteoid formation. J Vet Med Sci; 2007 Nov;69(11):1155-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathology of canine oral malignant melanoma with cartilage and/or osteoid formation.
  • Of 197 cases of canine oral malignant melanoma, 29 cases with myxoid, cartilage, and osteoid formation were studied pathologically and immunohistochemically.
  • Melanin-producing melanocytes were proliferating in the collagenous matrixes, while amelanotic cells were in the osteoid matrixes.

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  • (PMID = 18057830.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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