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Items 1 to 100 of about 176
41. Ladoyanni E, Abdullah A, Sterne GD, Zaki I: Amelanotic melanoma--"to be or not to be". Acta Derm Venereol; 2006;86(2):189-90
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  • [Title] Amelanotic melanoma--"to be or not to be".
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged

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  • (PMID = 16648938.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Norway
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42. Dickinson RM, Young KM: Cutaneous mass aspirate from a Golden Retriever: "glandular guile". Vet Clin Pathol; 2005 Dec;34(4):421-4
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  • On cytologic evaluation of a fine-needle aspirate of the mass, the interpretation was a malignant tumor with predominantly mesenchymal features.
  • Differentials included liposarcoma, atypical amelanotic melanoma, anaplastic sarcoma, and anaplastic carcinoma.
  • Following complete excision of the mass, a diagnosis of sebaceous adenocarcinoma was made based on histologic features, positive immunostaining for pancytokeratin, and negative staining for vimentin, Melan-A, and S-100.

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  • (PMID = 16270273.001).
  • [ISSN] 0275-6382
  • [Journal-full-title] Veterinary clinical pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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43. Lee SH, Hong JS, Choi JH, Chung WS: Choroidal schwannoma. Acta Ophthalmol Scand; 2005 Dec;83(6):754-6
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  • CONCLUSIONS: We enucleated the eyeball with a clinical diagnosis of choroidal amelanotic melanoma, but the tumor was finally diagnosed as schwannoma.
  • [MeSH-minor] Aged. Diagnosis, Differential. Eye Enucleation. Female. Humans. Magnetic Resonance Imaging. Visual Acuity

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  • (PMID = 16396657.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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4
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4. Conforti F, Menichini F, Rigano D, Senatore F: Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes. Z Naturforsch C; 2009 Jul-Aug;64(7-8):490-4
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  • The in vitro cytotoxic activity assay against two human cancer cell lines, large lung carcinoma (CORL-23) and amelanotic melanoma (C32), showed that the most antiproliferative extract was the MeOH extract from flowers with a percentage of inhibition of 50.9 at 100 microg/ml against amelanotic melanoma cells.
  • The most antiproliferative compounds against amelanotic melanoma cells were kaempferol-3-O-beta-D-glucopyranoside and irisolidone with a percentage of inhibition of 100 and 96.6, respectively, and against large lung carcinoma cells with a percentage of inhibition of 82.1 and 84.6, respectively.
  • Significant activity on the amelanotic melanoma cell line was also showed by irigenin-7-O-beta-D-glucopyranoside, with a percentage of inhibition of 89.3.
  • The compounds isovitexin and isoorientin-6-O''-beta-D-glucopyranoside showed a selective activity against amelanotic melanoma cells with a percentage of inhibition of 83.2 and 79.8, respectively.
  • [MeSH-minor] Carcinoma, Large Cell / pathology. Cell Line, Tumor. Humans. Lung Neoplasms / pathology. Melanoma, Amelanotic / pathology. Plant Extracts / chemistry. Polyphenols

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  • (PMID = 19791498.001).
  • [ISSN] 0939-5075
  • [Journal-full-title] Zeitschrift für Naturforschung. C, Journal of biosciences
  • [ISO-abbreviation] Z. Naturforsch., C, J. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Flavonoids; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols
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45. Peterson J, Rowley M: Rhinophymatous amelanotic melanoma. Cutis; 2007 May;79(5):383-6
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  • [Title] Rhinophymatous amelanotic melanoma.
  • Amelanotic melanomas are well-known to mimic other dermatologic lesions and often result in delayed diagnosis and treatment.
  • We report a case of an unusual presentation of amelanotic melanoma with an appearance similar to rhinophyma.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Male. Nose / pathology. Rhinoplasty. Surgical Flaps

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  • (PMID = 17569401.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Latendresse JR, Muskhelishvili L, Warbritton A, Tolleson WH: Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice. Toxicol Pathol; 2007 Oct;35(6):827-32
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  • [Title] Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice.
  • Uveal melanoma (UM) is uncommon among wild type mice.
  • Reported here are two early stage intraocular amelanotic melanomas discovered in 2 Tyr-HRAS+ Ink4a/Arf heterozygous (1 normal CKDN2A allele) transgenic FVB/n mice.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p16 / genetics. Disease Models, Animal. Genes, ras. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / genetics. Uveal Neoplasms / pathology

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  • (PMID = 17987514.001).
  • [ISSN] 0192-6233
  • [Journal-full-title] Toxicologic pathology
  • [ISO-abbreviation] Toxicol Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; EC 1.14.18.1 / Monophenol Monooxygenase
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47. Donaldson MJ, Lim L, Harper CA, Mackenzie J, G Campbell W: Primary treatment of choroidal amelanotic melanoma with photodynamic therapy. Clin Exp Ophthalmol; 2005 Oct;33(5):548-9
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  • [Title] Primary treatment of choroidal amelanotic melanoma with photodynamic therapy.
  • The management of choroidal melanoma involves a delicate balance between preserving vision and preventing metastasis.
  • Transpupillary thermotherapy avoids these side-effects; however, it can also result in visual loss and its effectiveness is limited in amelanotic lesions.
  • Photodynamic therapy with verteporfin has shown promise in animal studies of choroidal melanoma, and has recently been used in the management of lesions that have failed to respond to conventional therapy.
  • The authors report a case of primary treatment of a small choroidal amelanotic melanoma with photodynamic therapy using verteporfin.
  • [MeSH-major] Choroid Neoplasms / drug therapy. Melanoma, Amelanotic / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use. Porphyrins / therapeutic use

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  • [CommentIn] Clin Exp Ophthalmol. 2006 Sep-Oct;34(7):721; author reply 721-2 [16970777.001]
  • (PMID = 16181294.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 129497-78-5 / verteporfin
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48. Wen YH, Giashuddin S, Shapiro RL, Velazquez E, Melamed J: Unusual occurrence of a melanoma with intermixed epithelial component: a true melanocarcinoma?: case report and review of epithelial differentiation in melanoma by light microscopy and immunohistochemistry. Am J Dermatopathol; 2007 Aug;29(4):395-9
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  • [Title] Unusual occurrence of a melanoma with intermixed epithelial component: a true melanocarcinoma?: case report and review of epithelial differentiation in melanoma by light microscopy and immunohistochemistry.
  • Histological examination showed a malignant nodular neoplasm with 2 distinct but intimately admixed components: a malignant melanoma with a spindle component and an unusual glandular component.
  • A single melanocytic marker (MITF) was expressed in both components, raising the possibility of dual differentiation in a single tumor, rather than the alternative considerations of a collision tumor or a reactive pseudoepitheliomatous hyperplasia with eccrine duct lumen formation within a melanoma.
  • This unusual tumor with both melanocytic and epithelial components may represent a true melanocarcinoma, which becomes a plausible consideration, in view of melanoma plasticity and recent experimental evidence and speculation about the role of stem cells in melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Neoplasms, Glandular and Epithelial / pathology. Neoplasms, Multiple Primary / pathology. Scalp / pathology. Skin Neoplasms / pathology

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  • (PMID = 17667176.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MITF protein, human; 0 / Microphthalmia-Associated Transcription Factor; 68238-35-7 / Keratins
  • [Number-of-references] 41
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49. Harwood M, Telang GH, Robinson-Bostom L, Jellinek N: Melanoma and squamous cell carcinoma on different nails of the same hand. J Am Acad Dermatol; 2008 Feb;58(2):323-6
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  • [Title] Melanoma and squamous cell carcinoma on different nails of the same hand.
  • Unfamiliarity with tumors of the nail apparatus can lead to a delay in diagnosis.
  • A case is presented of a patient with two separate and concurrent malignant neoplasms of the nail unit, on different nails on the same hand, each featuring an unusual clinical presentation: amelanotic melanoma presenting as longitudinal erythronychia and squamous cell carcinoma in situ presenting as longitudinal melanonychia.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Melanoma, Amelanotic / pathology. Nail Diseases / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology

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  • (PMID = 18222331.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Yoon TY, Kim HJ, Kim JW, Kim MK, Lee JY: Bowen's disease concealed by purpura. J Dermatol; 2007 Jan;34(1):65-7
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  • Clinically, BD is frequently misdiagnosed as superficial basal cell carcinoma, patches of dermatitis, psoriasis, lichen planus, actinic keratosis, benign lichenoid keratosis, irritated seborrheic keratosis, viral warts, amelanotic melanoma or melanoma.
  • However, angiosarcoma has not usually been mentioned in the differential diagnosis of BD before.
  • [MeSH-major] Bowen's Disease / complications. Purpura / complications. Scalp. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans

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  • (PMID = 17204105.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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51. Ren G, Miao Z, Liu H, Jiang L, Limpa-Amara N, Mahmood A, Gambhir SS, Cheng Z: Melanin-targeted preclinical PET imaging of melanoma metastasis. J Nucl Med; 2009 Oct;50(10):1692-9
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  • [Title] Melanin-targeted preclinical PET imaging of melanoma metastasis.
  • Dialkylamino-alkyl-benzamides possess an affinity for melanin, suggesting that labeling of such benzamides with (18)F could potentially produce melanin-targeted PET probes able to identify melanotic melanoma metastases in vivo with high sensitivity and specificity.
  • In vivo distribution and small-animal PET studies were conducted on mice bearing B16F10 melanoma, A375M amelanotic melanoma, and U87MG tumors, and comparative studies were performed with (18)F-FDG PET in the melanoma models.
  • In vivo, (18)F-FBZA displayed significant tumor uptake; at 2 h, 5.94 +/- 1.83 percentage injected dose (%ID) per gram was observed in B16F10 tumors and only 0.75 +/- 0.09 %ID/g and 0.56 +/- 0.13 %ID/g was observed in amelanotic A375M and U87MG tumors, respectively.
  • CONCLUSION: (18)F-FBZA specifically targets primary and metastatic melanotic melanoma lesions with high tumor uptake and may have translational potential.

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  • (PMID = 19759116.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA114747; United States / NCI NIH HHS / CA / R24 CA93862
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzamides; 0 / Fluorine Radioisotopes; 0 / Melanins; 0 / Receptors, sigma
  • [Other-IDs] NLM/ NIHMS636087; NLM/ PMC4215196
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52. Godbole D, Mojamdar M, Pal JK: Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis. Cell Biol Int; 2006 Nov;30(11):895-902
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  • [Title] Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
  • Proteasomes have been shown to be involved in the regulation of melanin biosynthesis in melanoma cells.
  • Here we report on the correlation between proteasome subunits and Tyrosinase (Tyr) activity in different cell phenotypes, and thereby regulation of melanin biosynthesis in B16F10 mouse melanoma cells.
  • Our results indicated that the quantity of proteasome subunit p27 is higher and that of the enzyme Tyr and its activity are lower in amelanotic melanoma cells, while the reverse is true in melanotic melanoma cells.
  • Proteasome subunit p27, compared to another subunit p31, shows increased co-localization with Tyr and Tyrosinase related protein 1 (Trp1) in amelanotic cells to a greater extent than that in melanotic cells.
  • On exposure to cycloheximide, increased Tyr degradation was seen in amelanotic cells, as indicated by increased co-localization of p27 and Tyr.
  • Further, exposure of amelanotic melanoma cells with proteasome-specific inhibitor MG132 resulted in an increased Tyr activity, increased levels of Tyr and Trp1, leading to increased melanin synthesis.
  • These results therefore suggest that proteasomes, particularly p27 subunit, are directly involved in the regulation of melanin biosynthesis in mouse melanoma cells.
  • [MeSH-major] Melanins / biosynthesis. Melanoma, Amelanotic / enzymology. Melanoma, Amelanotic / pathology. Monophenol Monooxygenase / metabolism. Proteasome Endopeptidase Complex / metabolism. Protein Subunits / metabolism

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  • (PMID = 16879986.001).
  • [ISSN] 1065-6995
  • [Journal-full-title] Cell biology international
  • [ISO-abbreviation] Cell Biol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Leupeptins; 0 / Melanins; 0 / Proteasome Inhibitors; 0 / Protein Subunits; 133407-82-6 / benzyloxycarbonylleucyl-leucyl-leucine aldehyde; 98600C0908 / Cycloheximide; EC 1.- / Oxidoreductases; EC 1.14.18.- / tyrosinase-related protein-1; EC 1.14.18.1 / Monophenol Monooxygenase; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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53. Bonesi M, Tundis R, Deguin B, Loizzo MR, Menichini F, Tillequin F, Menichini F: In vitro biological evaluation of novel 7-O-dialkylaminoalkyl cytotoxic pectolinarigenin derivatives against a panel of human cancer cell lines. Bioorg Med Chem Lett; 2008 Oct 15;18(20):5431-4
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  • The effect of novel pectolinarigenin derivatives bearing a dialkylaminoalkyl substituent at O-7 on cell proliferation was evaluated in vitro in a panel of seven human cancer cell lines including renal adenocarcinoma ACHN, amelanotic melanoma C32, colorectal adenocarcinoma Caco-2, lung large cell carcinoma COR-L23, malignant melanoma A375, lung carcinoma A549 and hepatocellular carcinoma Huh-7D12 cell lines.
  • None of the tested compounds affected the proliferation of skin fibroblasts 142BR suggesting a selective activity against tumor cells.

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  • (PMID = 18818071.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Chromones; 0 / Flavones; 0 / Rhodamines; 0 / pectolinarigenin; 2609-88-3 / lissamine rhodamine B
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54. Valdes A, Kulekowskis AM, Curtis L: Case report: amelanotic melanoma located on the lower extremity. Am Fam Physician; 2007 Dec 1;76(11):1614, 1618
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report: amelanotic melanoma located on the lower extremity.
  • [MeSH-major] Foot. Melanoma, Amelanotic. Skin Neoplasms

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  • [CommentOn] Am Fam Physician. 2005 Jul 15;72(2):269-76 [16050450.001]
  • (PMID = 18092703.001).
  • [ISSN] 0002-838X
  • [Journal-full-title] American family physician
  • [ISO-abbreviation] Am Fam Physician
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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55. Khaled A, Hammami H, Fazaa B, Kourda N, Kamoun MR, Ben Jilany S, Zoghlami A: Primary amelanotic anorectal melanoma: an uncommon neoplasia with poor prognosis. Pathologica; 2009 Jun;101(3):126-9
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  • [Title] Primary amelanotic anorectal melanoma: an uncommon neoplasia with poor prognosis.
  • BACKGROUND: Anorectal melanoma is a rare and aggressive mucosal cancer.
  • There is usually a delay in diagnosis because about 30% of these cancers are amelanotic and are often mistaken for benign conditions.
  • Herein, we report a case of amelanotic anorectal malignant melanoma with an unusual metastatic deposit in the vulva and also review the literature.
  • Clinical examination showed a pedunculated and ulcerated amelanotic tumour associated with three other nodules, 1 cm in diameter, localized in the vulval mucosa.
  • Histological examination and immunohistochemical staining of all tumours demonstrated malignant melanoma.
  • DISCUSSION: Nine cases of amelanotic malignant melanoma have been reported in the literature.
  • The age at diagnosis ranged from 45 to 77 years.
  • Anorectal melanoma is most common in the rectum, followed by the anal canal.
  • Our case is the tenth case of amelanotic anorectal melanoma and probably corresponds to multiple synchronous primary melanomas of the anorectal region and the vulva, with the possibility that one of the lesions is a primary melanoma and the others are satellite lesions.
  • [MeSH-major] Anus Neoplasms / pathology. Melanoma, Amelanotic / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / pathology

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  • (PMID = 19886548.001).
  • [ISSN] 0031-2983
  • [Journal-full-title] Pathologica
  • [ISO-abbreviation] Pathologica
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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56. Chen KG, Leapman RD, Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ, Gottesman MM: Influence of melanosome dynamics on melanoma drug sensitivity. J Natl Cancer Inst; 2009 Sep 16;101(18):1259-71
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  • [Title] Influence of melanosome dynamics on melanoma drug sensitivity.
  • BACKGROUND: Malignant melanomas are intrinsically resistant to many conventional treatments, such as radiation and chemotherapy, for reasons that are poorly understood.
  • RESULTS: Endogenous melanogenic cytotoxicity, produced by damaged melanosomes, resulted in pronounced cell growth inhibition in MNT-1 cells compared with amelanotic SK-MEL-28 cells.
  • CONCLUSIONS: Melanosome dynamics (including their biogenesis, density, status, and structural integrity) regulate the drug resistance of melanoma cells.
  • Manipulation of melanosome functions may be an effective way to enhance the therapeutic activity of anticancer drugs against melanoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / pharmacology. Drug Resistance, Neoplasm. Melanoma / drug therapy. Melanoma / pathology. Melanosomes / drug effects. Melanosomes / ultrastructure. Skin Neoplasms / drug therapy. Skin Neoplasms / pathology
  • [MeSH-minor] Animals. Cell Death / drug effects. Cell Line, Tumor. Cisplatin / pharmacology. Cyclosporins / pharmacology. Doxorubicin / pharmacology. Fluorescent Antibody Technique, Indirect. Humans. Melanoma, Experimental / drug therapy. Melanoma, Experimental / pathology. Mice. Microscopy, Confocal. Microscopy, Electron. Verapamil / pharmacology. Vinblastine / pharmacology

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  • (PMID = 19704071.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 NS999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclosporins; 121584-18-7 / valspodar; 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; CJ0O37KU29 / Verapamil; Q20Q21Q62J / Cisplatin
  • [Other-IDs] NLM/ PMC2744727
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57. Menzies SW, Kreusch J, Byth K, Pizzichetta MA, Marghoob A, Braun R, Malvehy J, Puig S, Argenziano G, Zalaudek I, Rabinovitz HS, Oliviero M, Cabo H, Ahlgrimm-Siess V, Avramidis M, Guitera P, Soyer HP, Ghigliotti G, Tanaka M, Perusquia AM, Pagnanelli G, Bono R, Thomas L, Pellacani G, Langford D, Piccolo D, Terstappen K, Stanganelli I, Llambrich A, Johr R: Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. Arch Dermatol; 2008 Sep;144(9):1120-7
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  • [Title] Dermoscopic evaluation of amelanotic and hypomelanotic melanoma.
  • OBJECTIVE: To determine the predictive dermoscopic features of amelanotic and hypomelanotic melanoma.
  • DESIGN: A total of 105 melanomas (median Breslow thickness, 0.76 mm), 170 benign melanocytic lesions, and 222 nonmelanocytic lesions lacking significant pigment (amelanotic, partially pigmented, and light colored) were imaged using glass-plate dermoscopy devices and scored for 99 dermoscopic features.
  • MAIN OUTCOME MEASURES: Sensitivity, specificity, and odds ratios for individual features and models for the diagnosis of melanoma and malignancy.
  • RESULTS: The most significant negative predictors of melanoma were having multiple (>3) milialike cysts (odds ratio, 0.09; 95% confidence interval, 0.01-0.64), comma vessels with a regular distribution (0.10; 0.01-0.70), comma vessels as the predominant vessel type (0.16; 0.05-0.52), symmetrical pigmentation pattern (0.18; 0.09-0.39), irregular blue-gray globules (0.20; 0.05-0.87), and multiple blue-gray globules (0.28; 0.10-0.81).
  • A model distinguishing all malignant lesions from benign lesions had a sensitivity of 96% and a specificity of 37%.
  • Conclusion Although the diagnostic accuracy of dermoscopy for melanoma lacking significant pigment is inferior to that of more pigmented lesions, features distinguishing the former from benign lesions can be visualized on dermoscopic evaluation.
  • [MeSH-major] Dermoscopy. Melanoma / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology. Skin Pigmentation
  • [MeSH-minor] Diagnosis, Differential. Humans. Models, Biological. Observer Variation. Predictive Value of Tests. Sensitivity and Specificity


58. Traynor NJ, McKenzie RC, Beckett GJ, Gibbs NK: Selenomethionine inhibits ultraviolet radiation-induced p53 transactivation. Photodermatol Photoimmunol Photomed; 2006 Dec;22(6):297-303
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  • BACKGROUND: Ultraviolet (UV) radiation damages the cellular DNA of skin cells.
  • METHODS: We examined whether selenomethionine could protect human skin cells from UV radiation-induced p53 transactivation, using a pRGCDeltafos-lacZ p53-dependent reporter construct stably transfected in an amelanotic melanoma cell line (Arn-8) which expresses wild-type p53.
  • [MeSH-major] Radiation-Protective Agents / pharmacology. Selenomethionine / pharmacology. Skin / drug effects. Skin / radiation effects. Ultraviolet Rays

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  • (PMID = 17100737.001).
  • [ISSN] 0905-4383
  • [Journal-full-title] Photodermatology, photoimmunology & photomedicine
  • [ISO-abbreviation] Photodermatol Photoimmunol Photomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Radiation-Protective Agents; 0 / Tumor Suppressor Protein p53; 964MRK2PEL / Selenomethionine
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59. Wachulska M, Kozłowska K, Cichorek M: The DNA ploidy and proliferative activity of transplantable melanoma cells in regard to their secretory function. Neoplasma; 2005;52(4):280-6
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  • [Title] The DNA ploidy and proliferative activity of transplantable melanoma cells in regard to their secretory function.
  • The study concerns DNA ploidy and proliferative activity of the cells of two hamster transplantable melanoma lines - differing in many biological features - in the light of possible changes in their secretory activity.
  • Our results indicate that melanotic melanoma cells (Ma) have a near-tetraploid DNAcontent and about 18% of proliferating cells, while amelanotic melanoma cells (Ab) - have a near-triploid DNA content and almost twice as many proliferating cells.
  • The Ab cells, in comparison with Ma cells, secreted in vitro less total protein and most of the cytokines examined except OSM, but a spontaneous alteration of transplantable melanoma was accompanied by an increase of the quantity and dynamics of NO secretion.
  • So, the cells of two melanoma lines have their own characteristic pattern of secretory function.
  • But, the aneuploidy which accompanied the changes in cell differentiation of the studied melanoma lines, although seemed to reflect their changes in the proliferative activity, nevertheless did not reflect, in a direct way, differences in the secretion of the substances studied.
  • [MeSH-major] DNA, Neoplasm / analysis. Melanoma / pathology. Melanoma / secretion. Ploidies. Skin Neoplasms / pathology. Skin Neoplasms / secretion


60. Camerin M, Magaraggia M, Soncin M, Jori G, Moreno M, Chambrier I, Cook MJ, Russell DA: The in vivo efficacy of phthalocyanine-nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma. Eur J Cancer; 2010 Jul;46(10):1910-8
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  • [Title] The in vivo efficacy of phthalocyanine-nanoparticle conjugates for the photodynamic therapy of amelanotic melanoma.
  • The efficiency of a Zn(II)-phthalocyanine disulphide (C11Pc), a compound with both phthalocyanine units bearing seven hexyl chains and a sulphur terminated C11 chain, as a photodynamic therapy (PDT) agent was investigated in C57 mice bearing a sub-cutaneously transplanted amelanotic melanoma.
  • Biodistribution studies at selected post-injection times showed that the nanoparticle-associated C11Pc was recovered in significantly larger amounts from all the examined tissues and the serum and yielded a greater selectivity of tumour targeting: thus, the ratio between the amount of phthalocyanine recovered from the amelanotic melanoma and the skin (peritumoural tissue) increased from 2.3 to 5.5 from the free to the gold nanoparticle-bound C11Pc at 24 h after injection.
  • PDT studies with the C11Pc-loaded amelanotic melanoma showed a markedly more significant response of the tumour in the mice that had received the nanoparticle-bound photosensitiser; the PDT effect was especially extensive if the irradiation was performed at 3h after C11Pc injection when large phthalocyanine amounts were still present in the serum.
  • [MeSH-major] Indoles / therapeutic use. Melanoma, Amelanotic / drug therapy. Metal Nanoparticles / therapeutic use. Organometallic Compounds / therapeutic use. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20356732.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / C22031/A7097
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Indoles; 0 / Organometallic Compounds; 0 / Photosensitizing Agents; 14320-04-8 / Zn(II)-phthalocyanine
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61. Roy S, Dhingra K, Mandal S, Khurana N: Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump. Melanoma Res; 2008 Dec;18(6):447-50
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  • [Title] Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump.
  • Past history was unremarkable for skin lesions, biopsy or any surgery.
  • The lump was hard and freely mobile with normal overlying skin, nipple, and areola.
  • Careful examination of the skin did not reveal any lesion.
  • Immunoreactivity for S-100 and HMB-45, confirmed the diagnosis of amelanotic melanoma.
  • It is important to be aware of this atypical presentation of amelanotic melanoma in the breast and to utilize immunohistochemistry to differentiate from other commoner high-grade malignant tumors.
  • [MeSH-major] Breast Neoplasms / secondary. Melanoma, Amelanotic / secondary. Neoplasms, Unknown Primary / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Antigens, Neoplasm / metabolism. Female. Humans. Melanoma-Specific Antigens. Neoplasm Proteins / metabolism. S100 Proteins / metabolism

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  • (PMID = 18971788.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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62. de Giorgi V, Sestini S, Massi D, Maio V, Giannotti B: Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study. J Am Acad Dermatol; 2006 Feb;54(2):341-4
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  • [Title] Dermoscopy for "true" amelanotic melanoma: a clinical dermoscopic-pathologic case study.
  • Completely amelanotic melanomas are rare and therefore often misclassified, with tragic consequences for patients.
  • The analysis of the vascular pattern, which is often the only dermoscopic parameter to be seen, is therefore essential for a correct diagnosis.
  • We present a case of "true" amelanotic melanoma on the forehead of an 89-year-old man, which clinically mimicked squamous cell carcinoma.
  • The dermoscopic diagnostic algorithms routinely used for pigmented lesions are not helpful in diagnosing amelanotic melanoma because they are based on specific parameters not normally seen in amelanotic lesions.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / pathology
  • [MeSH-minor] Aged. Algorithms. Humans. Male. Melanocytes / pathology. Skin Neoplasms / pathology

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  • [CommentIn] J Am Acad Dermatol. 2006 Oct;55(4):728 [17010767.001]
  • (PMID = 16443072.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Castillo O, Frisancho O, Palomino A: [Cecal amelanotic melanoma]. Rev Gastroenterol Peru; 2010 Oct-Dec;30(4):368-71
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  • [Title] [Cecal amelanotic melanoma].
  • [Transliterated title] Melanoma amelanótico en ciego.
  • Subsequently, we confirmed the presence of red blood in stools, like enterorrhagia and underwent a colonoscopy, in which two elevated lesions were found in the cecum: a pedunculated (with active bleeding, oozing) and other sessile; both were removed. the pathology showed that corresponded to amelanotic melanoma in cecal region.
  • Physical examination revealed no malignant skin lesions.
  • We report this case, because gastrointestinal bleeding is an unusual clinical presentation of malignant melanoma.
  • [MeSH-major] Cecal Neoplasms / pathology. Melanoma / pathology

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  • (PMID = 21263766.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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64. Elizalde J, Ubia S, Barraquer RI: Adenoma of the nonpigmented ciliary epithelium. Eur J Ophthalmol; 2006 Jul-Aug;16(4):630-3
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  • Adenoma of the non pigmented ciliary epithelium may mimic an amelanotic melanoma.
  • Partial lamellar sclerouvectomy is an effective method to manage this condition and to confirm the diagnosis.

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  • (PMID = 16952109.001).
  • [ISSN] 1120-6721
  • [Journal-full-title] European journal of ophthalmology
  • [ISO-abbreviation] Eur J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Wain EM, Stefanato CM, Barlow RJ: A clinicopathological surprise: amelanotic malignant melanoma. Clin Exp Dermatol; 2008 May;33(3):365-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinicopathological surprise: amelanotic malignant melanoma.
  • [MeSH-major] Melanocytes / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Mohs Surgery / methods. Treatment Outcome

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  • (PMID = 18419612.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 6
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66. Gosselink CP, Sindone JL, Meadows BJ, Mohammadi A, Rosa M: Amelanotic subungual melanoma: a case report. J Foot Ankle Surg; 2009 Mar-Apr;48(2):220-4
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  • [Title] Amelanotic subungual melanoma: a case report.
  • Subungual melanoma is a disorder that accounts for 2% to 3% of all melanoma cases.
  • We report the case of a 31-year-old male patient presenting with a rapidly growing mass localized to the hallux, which eventually resulted in the diagnosis of an ulcerated amelanotic subungual melanoma.
  • Because of their lack of pigmentation, amelanotic melanoma is frequently misdiagnosed for other more common forms of cutaneous compromise, and a delay in proper treatment because of failure to make the diagnosis can greatly decrease the likelihood of a favorable outcome.
  • [MeSH-major] Hallux. Melanoma, Amelanotic / pathology. Nail Diseases / pathology. Skin Neoplasms / pathology

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  • (PMID = 19232976.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Sbai MA, Boussen M, Mankai I, Souissi M, Day SC, Korbi A, Tebib M: [Amelanotic malignant melanoma of the great toe]. Tunis Med; 2010 Feb;88(2):130-1
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  • [Title] [Amelanotic malignant melanoma of the great toe].
  • [Transliterated title] Mélanome malin achromique de l'hallux.
  • [MeSH-major] Hallux / surgery. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 20415177.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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68. Auer-Grumbach M: Hereditary sensory neuropathy type I. Orphanet J Rare Dis; 2008;3:7
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  • Hereditary sensory neuropathy type I (HSN I) is a slowly progressive neurological disorder characterised by prominent predominantly distal sensory loss, autonomic disturbances, autosomal dominant inheritance, and juvenile or adulthood disease onset.
  • Variable distal muscle weakness and wasting, and chronic skin ulcers are characteristic.
  • Diagnosis is based on the clinical observation and is supported by a family history.
  • Definitive diagnosis is based on the detection of mutations by direct sequencing of the SPTLC1 and RAB7 genes.
  • Correct clinical assessment and genetic confirmation of the diagnosis are important for appropriate genetic counselling and prognosis.
  • Differential diagnosis includes the other hereditary sensory and autonomic neuropathies (HSAN), especially HSAN II, as well as diabetic foot syndrome, alcoholic neuropathy, neuropathies caused by other neurotoxins/drugs, immune mediated neuropathy, amyloidosis, spinal cord diseases, tabes dorsalis, lepra neuropathy, or decaying skin tumours like amelanotic melanoma.
  • The disorder is slowly progressive and does not influence life expectancy but is often severely disabling after a long duration of the disease.

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  • (PMID = 18348718.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 35
  • [Other-IDs] NLM/ PMC2311280
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69. von Felbert V, Abuzahra F: [Two rarely seen manifestations of malignant melanoma]. Hautarzt; 2007 May;58(5):390-2
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  • [Title] [Two rarely seen manifestations of malignant melanoma].
  • [MeSH-major] Melanoma, Amelanotic / pathology. Nail Diseases / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasms, Multiple Primary / pathology. Skin / pathology. Thyroid Neoplasms / pathology

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  • (PMID = 17447038.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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70. Rizvi SA, Amitava AK, Mehdi G, Sharma R, Alam MS: Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association. Indian J Ophthalmol; 2008 Sep-Oct;56(5):421-3
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  • [Title] Orbital amelanotic melanoma in xeroderma pigmentosum: a rare association.
  • Xeroderma pigmentosum (XP) is an autosomal recessive genetic disorder of DNA repair in which the body's normal ability to repair damage caused by ultraviolet light is deficient.
  • Ocular neoplasms occurring in XP in order of frequency are squamous cell carcinoma, basal cell carcinoma and melanoma.
  • Malignant melanomas occur at an early age in patients with XP.
  • We report a case of XP with massive orbital melanoma in an eight-year-old boy which is unique due to its amelanotic presentation confirmed histopathologically.
  • [MeSH-major] Melanoma, Amelanotic / complications. Orbit. Skin Neoplasms / complications. Xeroderma Pigmentosum / complications
  • [MeSH-minor] Child. Diagnosis, Differential. Humans. Male. Ophthalmologic Surgical Procedures / methods

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  • (PMID = 18711275.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2636150
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71. Morita N, Hiratsuka J, Kondoh H, Uno M, Asano T, Niki Y, Sakurai Y, Ono K, Harada T, Imajo Y: Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene. Cancer Res; 2006 Apr 1;66(7):3747-53
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  • [Title] Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
  • In melanoma, (10)B-para-boronophenylalanine (BPA) accumulation is proportional to melanin-producing activity.
  • This study was done to confirm enhancement of the tumor-suppressive effect of BNCT on amelanotic melanoma by intratumoral injection of the tyrosinase gene.
  • D178 or FF amelanotic melanomas were implanted s.c. in Syrian hamsters.
  • In vivo transfection with the tyrosinase gene increased BPA accumulation in the tumors, the BNCT tumor-suppressive effect on amelanotic melanoma being significantly enhanced.
  • These findings suggest a potential new clinical strategy for the treatment of amelanotic melanoma with BNCT.
  • [MeSH-major] Boron Neutron Capture Therapy / methods. Genetic Therapy / methods. Melanoma, Amelanotic / enzymology. Melanoma, Amelanotic / radiotherapy. Monophenol Monooxygenase / genetics. Skin Neoplasms / enzymology. Skin Neoplasms / radiotherapy

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  • (PMID = 16585201.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Boron Compounds; 0 / Radiation-Sensitizing Agents; 47E5O17Y3R / Phenylalanine; EC 1.14.18.1 / Monophenol Monooxygenase; UID84303EL / 4-boronophenylalanine
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72. Sbano P, Nami N, Grimaldi L, Rubegni P: True amelanotic melanoma: the great masquerader. J Plast Reconstr Aesthet Surg; 2010 Mar;63(3):e307-8
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  • [Title] True amelanotic melanoma: the great masquerader.
  • [MeSH-major] Dermoscopy. Melanoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19713163.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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73. Jacob S, Pye E, Hbahbih M, Messios N, Rajabally YA: Rapidly progressive bilateral ophthalmoplegia and enlarging sellar mass caused by amelanotic melanoma. J Neuroophthalmol; 2006 Mar;26(1):49-50
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  • [Title] Rapidly progressive bilateral ophthalmoplegia and enlarging sellar mass caused by amelanotic melanoma.
  • Hypophysectomy disclosed an amelanotic melanoma.
  • Despite local radiation treatment, the tumor continued to grow and the patient became blind and died within several months of diagnosis.
  • There are seven reported cases of melanoma arising primarily in the sella turcica.
  • Two cases of metastatic melanoma to the cavernous sinuses have been reported.
  • Amelanotic melanoma has not been reported as a cause of cavernous sinus syndrome.
  • [MeSH-major] Melanoma, Amelanotic / complications. Ophthalmoplegia / etiology. Pituitary Neoplasms / complications. Sella Turcica / pathology
  • [MeSH-minor] Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Hypophysectomy. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16518168.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Lazarević V, Tiodorović J, Tiodorović-Zivković D, Stanojević M, Popović D, Janković A: Immunophenotyping of amelanotic melanoma. A case report. Acta Dermatovenerol Alp Pannonica Adriat; 2006 Sep;15(3):141-3
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  • [Title] Immunophenotyping of amelanotic melanoma. A case report.
  • Amelanotic malignant melanoma (AMM) is a subtype of cutaneous melanoma with little or no pigment upon visual inspection.
  • The lack of pigmentation is the reason for late diagnosis of lesions and a poor prognosis.
  • In doubtful cases, immunophenotyping with monoclonal antibodies HMB-45 and S-100 is important for confirming the correct diagnosis of AMM.
  • [MeSH-major] Melanoma, Amelanotic / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antibodies / therapeutic use. Antibodies, Monoclonal / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Immunophenotyping. Keratins / immunology. Middle Aged. S100 Proteins / immunology

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  • (PMID = 17053850.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antibodies, Monoclonal; 0 / S100 Proteins; 68238-35-7 / Keratins
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75. Kurotaki T, Tomonari Y, Kanno T, Wako Y, Tsuchitani M: A novel immunohistochemical marker of normal and neoplastic melanocytes in formalin-fixed, paraffin-embedded tissues of albino rats. Vet Pathol; 2008 May;45(3):383-7
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  • In albino rats, spontaneous occurrence of melanocytic tumors is rare, with diagnosis difficult.
  • The samples consisted of 11 (1.57%) amelanotic melanomas in 700 rats (2 studies), 23 non-melanocytic tumors, and a wide variety of normal tissues.
  • In amelanotic melanoma, the tumor cells consisted of spindle cells with eosinophilic cytoplasm without melanin granules.
  • PNL2 consistently stained cytoplasm in all amelanotic melanoma cells.
  • [MeSH-major] Melanocytes / cytology. Melanocytes / pathology. Melanoma / pathology

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  • (PMID = 18487499.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Mercadier B, Hu W, Valentin S, Sassolas B: [Amelanotic malignant melanoma: about three cases]. Ann Chir Plast Esthet; 2007 Feb;52(1):68-70
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  • [Title] [Amelanotic malignant melanoma: about three cases].
  • [Transliterated title] Mélanome malin achromique : à propos de trois cas.
  • The amelanotic melanoma is a rare type of malignant melanoma.
  • The purpose of this report is to point out this aspect of melanoma, whose diagnostic delay is frequent.
  • We describe one localisation on the penis, rare in this kind of melanoma and two cases of the extremities, more frequent localization of the amelanotic melanoma.
  • The therapeutic issues and recommendation are similar to the classical pigmented malignant melanoma.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 17030390.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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77. Stroh C, Manger T: [Primary amelanotic anorectal melanoma--a case report]. Zentralbl Chir; 2007 Dec;132(6):560-3
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  • [Title] [Primary amelanotic anorectal melanoma--a case report].
  • [Transliterated title] Das primäre amelanotische Melanom des Rektums - Ein Fallbericht.
  • BACKGROUND: The amelanotic melanoma of the rectal mucosa is very rare with an unfavourable prognosis.
  • Therefore transrectal ultrasound is of major importance in the preoperative staging and postoperative follow-up especially in diagnosis of local recurrence by using the ultrasound-guided, transrectal aspiration.
  • METHODS: In literature 5 cases of amelanotic malignant melanoma were reported.
  • The overall survival time is 10 months after diagnosis.
  • RESULTS: We report about a 55-year-old female patient with an amelanotic melanoma of rectal mucosa.
  • The patient died 36 months after diagnosis.
  • CONCLUSION: The prognosis of primary malignant anorectal melanoma is poor, irrespective of surgical treatment.
  • Wide local resection is the first choice for primary anorectal melanoma.
  • Chemotherapy, radiotherapy and immunotherapy should be considered in the treatment of anorectal melanoma to influence the overall survival.
  • [MeSH-major] Melanoma, Amelanotic / surgery. Rectal Neoplasms / surgery

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  • (PMID = 18098086.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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78. Sayk F, Mahnken A, Stellmacher F, Dalhoff K, Merz H: [Cancer-to-cancer metastasis: amelanotic melanoma into renal cell carcinoma]. Dtsch Med Wochenschr; 2010 Mar;135(11):507-10
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  • [Title] [Cancer-to-cancer metastasis: amelanotic melanoma into renal cell carcinoma].
  • DIAGNOSIS: The autopsy revealed that he was affected by two malignant neoplasms simultaneously: an amelanotic malignant melanoma metastasizing into a localized renal cell carcinoma.
  • This is the third reported case of a malignant melanoma as donor tumor spreading into a renal cell carcinoma.
  • The amelanotic character of the melanoma exerted a special diagnostic challenge.
  • Clinical and autopsy findings as well as the immunophenotypical features of the metastatic amelanotic melanoma (HMB-45, Melan-A/MART-1, S100) and the renal cell carcinoma are described with a review of the relevant literature.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Melanoma, Amelanotic / pathology

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 20221965.001).
  • [ISSN] 1439-4413
  • [Journal-full-title] Deutsche medizinische Wochenschrift (1946)
  • [ISO-abbreviation] Dtsch. Med. Wochenschr.
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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79. Harasymowycz P, Boucher MC, Corriveau C, Gauthier D, Allaire G: Choroidal amelanotic melanoma in a patient with oculocutaneous albinism. Can J Ophthalmol; 2005 Dec;40(6):754-8
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  • [Title] Choroidal amelanotic melanoma in a patient with oculocutaneous albinism.
  • CASE REPORT: We describe the clinical presentation of a choroidal amelanotic melanoma in a 46-year-old woman with oculocutaneous albinism.
  • Microscopic findings and histopathological features, demonstrating a spindle B-cell melanoma of the choroid, are also reviewed.
  • COMMENTS: Magnetic resonance imaging may be helpful in diagnosing amelanotic melanoma in patients with oculocutaneous albinism.

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  • (PMID = 16391642.001).
  • [ISSN] 0008-4182
  • [Journal-full-title] Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
  • [ISO-abbreviation] Can. J. Ophthalmol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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80. Harrison TM, Dominguez P, Hanzlik K, Sikarskie JG, Agnew D, Bergin I, Fitzgerald SD, Kitchell BE, McNiel E: Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi). J Zoo Wildl Med; 2010 Mar;41(1):152-7
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  • [Title] Treatment of an amelanotic melanoma using radiation therapy in a lesser Madagascar hedgehog tenrec (Echinops telfairi).
  • Immunohistochemically, the original, recurrent, and metastatic populations were strongly positive for HMB 45 and weakly positive for S-100, and the final diagnosis was metastatic amelanotic melanoma.
  • [MeSH-major] Insectivora. Melanoma, Amelanotic / veterinary

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  • (PMID = 20722271.001).
  • [ISSN] 1042-7260
  • [Journal-full-title] Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • [ISO-abbreviation] J. Zoo Wildl. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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81. Cavicchini S, Tourlaki A, Bottini S: Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma. Arch Dermatol; 2007 Apr;143(4):556
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  • [Title] Dermoscopic vascular patterns in nodular "pure" amelanotic melanoma.
  • [MeSH-major] Dermoscopy. Melanoma, Amelanotic / blood supply. Skin Neoplasms / blood supply

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  • (PMID = 17438200.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Pouckova P, Skvor J, Gotte G, Vottariello F, Slavik JT, Matousek J, Laurents DV, Libonati M, Soucek J: Some biological actions of PEG-conjugated RNase A oligomers. Neoplasma; 2006;53(1):79-85
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  • In this work we show that the chemical conjugation of PEG to the RNase A C-dimer, and to the two RNase A trimers (NC-trimer and C- trimer) decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB900518 amelanotic melanoma transplanted in athymic nude mice.
  • [MeSH-minor] Animals. Antispermatogenic Agents / pharmacology. Cell Line, Tumor. Dimerization. Embryo, Mammalian / drug effects. Humans. Male. Melanoma, Experimental / drug therapy. Mice. Neoplasm Transplantation. Spermatogenesis / drug effects

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  • (PMID = 16416018.001).
  • [ISSN] 0028-2685
  • [Journal-full-title] Neoplasma
  • [ISO-abbreviation] Neoplasma
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antispermatogenic Agents; 0 / Peptide Fragments; 30IQX730WE / Polyethylene Glycols; EC 3.1.27.5 / Ribonuclease, Pancreatic
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83. Koszałka P, Szmit E, Myśliwski A, Bigda J: Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters. Arch Immunol Ther Exp (Warsz); 2007 Jul-Aug;55(4):267-79
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  • [Title] Anti-tumor action of tumor necrosis factor against Bomirski Ab melanoma in hamsters.
  • MATERIALS AND METHODS: The effects of intratumoral injection of rat TNF into hamsters bearing Bomirski Ab amelanotic melanoma, a fast growing tumor of high metastatic potential, were tested.
  • In vitro assays indicated a direct cytotoxic effect of TNF against Ab melanoma cells, most probably as an outcome of apoptosis.
  • Intratumoral application of TNF also caused some modulation of cytokine response in melanoma-bearing hamsters as evidenced by increased levels of IL-6 in blood serum.
  • CONCLUSIONS: This study established Bomirski Ab melanoma as a useful model for complex analysis of the anti-tumor activity of TNF.
  • [MeSH-major] Angiogenesis Inhibitors / metabolism. Melanoma, Experimental / metabolism. Neovascularization, Pathologic / metabolism. Recombinant Proteins / metabolism. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 17659374.001).
  • [ISSN] 0004-069X
  • [Journal-full-title] Archivum immunologiae et therapiae experimentalis
  • [ISO-abbreviation] Arch. Immunol. Ther. Exp. (Warsz.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Cyclohexanes; 0 / Interleukin-6; 0 / Recombinant Proteins; 0 / Sesquiterpenes; 0 / Tumor Necrosis Factor-alpha; 129298-91-5 / O-(chloroacetylcarbamoyl)fumagillol
  • [Other-IDs] NLM/ PMC2766459
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84. Hillenbrand A, Barth TF, Henne-Bruns D, Formentini A: Anorectal amelanotic melanoma. Colorectal Dis; 2008 Jul;10(6):612-5
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  • [Title] Anorectal amelanotic melanoma.
  • OBJECTIVE: Anorectal melanoma is a rare, highly malignant tumour with a poor 5 year survival of 10%.
  • Most anorectal melanomas have gross and/or histologic pigmentation, however about 30% of anorectal melanomas are amelanotic.
  • METHOD: We report three cases of amelanotic anorectal melanomas and integrate our data with six case reports of amelanotic malignant melanoma from the literature.
  • Further we compare clinicopathological data and clinical outcome with large series of anorectal melanomas (both, amelanotic and pigmentated).
  • Rectal bleeding was the leading symptom in all cases with a mean duration of 4 months before diagnosis.
  • CONCLUSION: Early diagnosis is key for efficient treatment and improved survival rate for patients with this unusual variant of melanoma.
  • There is no difference in terms of age, time of diagnosis, stage and survival between pigmented and amelanotic anorectal melanoma.
  • [MeSH-major] Anus Neoplasms. Melanoma, Amelanotic. Rectal Neoplasms

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  • (PMID = 17944970.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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85. Matusiak L, Bieniek A, Wozniak Z, Szepietowski JC: Amelanotic malignant melanoma in an acral location. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Jun;17(2):72-4
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  • [Title] Amelanotic malignant melanoma in an acral location.
  • The biopsy, stained with H and E, revealed an anaplastic malignant tumor.
  • Additional immunochemical staining with Melan A allowed us to make the final diagnosis: amelanotic malignant melanoma (MM).
  • The melanoma was removed by amputation of digits IV and V, with partial removal of the metatarsal bones (Clark degree 5, Breslow thickness 9 mm).
  • [MeSH-major] Foot Dermatoses / pathology. Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology

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  • (PMID = 18709293.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovenia
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86. Mesa M, Quesada JL, Piñas J: Metastasis of amelanotic melanoma of unknown origin in the parotid gland. Br J Oral Maxillofac Surg; 2009 Oct;47(7):569-71
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  • [Title] Metastasis of amelanotic melanoma of unknown origin in the parotid gland.
  • We report a rare case of metastasis of an amelanotic melanoma of the parotid gland.
  • To our knowledge this is the first report of a metastasis of an amelanotic melanoma in a parotid lymph node.
  • [MeSH-major] Melanoma, Amelanotic / secondary. Neoplasms, Unknown Primary / pathology. Parotid Neoplasms / secondary
  • [MeSH-minor] Aged. Antigens, Neoplasm / analysis. Biopsy, Fine-Needle. Female. Humans. Lymphatic Metastasis / pathology. Magnetic Resonance Imaging. Melanoma-Specific Antigens. Neoplasm Proteins / analysis. S100 Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 19167137.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Melanoma-Specific Antigens; 0 / Neoplasm Proteins; 0 / S100 Proteins
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87. Gelpi E, Popovic M, Preusser M, Budka H, Hainfellner J: Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis. Neuropathology; 2005 Sep;25(3):241-6
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  • [Title] Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis.
  • In these cases, the differential diagnosis needs to exclude other malignancies, for example, glioblastoma or malignant fibrous histiocytoma.
  • These features led to the tentative diagnosis of amelanotic melanoma, and the patient was irradiated.
  • We conclude that non-standard GFAP staining protocols may enhance sensitivity and thus lead to detection of a low level of GFAP expression in tumor specimens, in which PXA is considered in the differential diagnosis.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Immunohistochemistry / methods. Melanoma / pathology. Microscopy, Confocal. Microscopy, Electron, Transmission. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology

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  • (PMID = 16193842.001).
  • [ISSN] 0919-6544
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein
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88. Cichorek M, Kozłowska K, Wachulska M, Zielińska K: Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth. Folia Histochem Cytobiol; 2006;44(1):31-6
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  • [Title] Spontaneous apoptosis of melanotic and amelanotic melanoma cells in different phases of cell cycle: relation to tumor growth.
  • Since the spontaneous alteration of native melanotic (Ma) into amelanotic (Ab) transplantable melanoma line it has been observed that this alteration is accompanied by the acceleration of growth of Ab line.
  • Apoptosis estimated by the TUNEL method, alterations in the plasma membrane structure (annexin V staining), changes in the mitochondrial transmembrane potential--delta psi m (JC-1 staining) showed that amelanotic melanoma cells have decreased ability to undergo spontaneous apoptosis.
  • The obtained results showing that in the native melanotic line about 30% of cells are in S+G2/M phases and that 33% of these cells undergo apoptosis could lead to the conclusion that the slower growth of this melanoma line is the result of lower proliferation activity and higher rate of apoptosis of these tumor cells.
  • The number of cells in S+G2/M phases in amelanotic melanoma line increases up to 40% and only 7% of them undergo apoptosis.
  • This observation seems to suggest that the expansive growth of this melanoma line depends mainly on the decreased ability to undergo spontaneous apoptosis, especially in case of cells from S+G2/M phases.
  • Moreover, the obtained results indicate that alteration of melanotic line into amelanotic one, accompanied by differences in many biological features also concerns basic cell processes such as cell cycle and cell death.

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  • (PMID = 16584089.001).
  • [ISSN] 0239-8508
  • [Journal-full-title] Folia histochemica et cytobiologica
  • [ISO-abbreviation] Folia Histochem. Cytobiol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Annexin A5; 0 / Phosphatidylserines
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89. Sinicropi MS, Caruso A, Conforti F, Marrelli M, El Kashef H, Lancelot JC, Rault S, Statti GA, Menichini F: Synthesis, inhibition of NO production and antiproliferative activities of some indole derivatives. J Enzyme Inhib Med Chem; 2009 Oct;24(5):1148-53
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  • The compounds prepared were evaluated for their inhibition of NO production, antioxidant activity and also for their ability to inhibit in vitro the growth of four human tumor cell lines: large lung carcinoma (COR-L23), alveolar basal epithelial carcinoma (A549), amelanotic melanoma (C32) and melanoma (A375).
  • Compound 5a was the most active against melanotic melanoma (IC(50) = 11.8 microM) while the other compounds exhibited weak cytotoxicity with IC(50) values >50 microM on all cell lines.

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  • (PMID = 19555184.001).
  • [ISSN] 1475-6374
  • [Journal-full-title] Journal of enzyme inhibition and medicinal chemistry
  • [ISO-abbreviation] J Enzyme Inhib Med Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Pyrans; 31C4KY9ESH / Nitric Oxide
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90. Silver EA, Hofmann AE, Williams D, Srolovitz H, Tahiri Y, Khanna M: Large amelanotic melanoma and vitiligo. Arch Dermatol; 2009 Oct;145(10):1198-9
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  • [Title] Large amelanotic melanoma and vitiligo.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Palliative Care. Skin Neoplasms / pathology. Vitiligo / diagnosis
  • [MeSH-minor] Adult. Back. Biopsy, Needle. Fatal Outcome. Female. Hand Dermatoses / diagnosis. Humans. Immunohistochemistry. Neoplasm Staging. Positron-Emission Tomography. Terminally Ill


91. Menichini F, Tundis R, Loizzo MR, Bonesi M, Provenzano E, de Cindio B, Menichini F: In vitro photo-induced cytotoxic activity of Citrus bergamia and C. medica L. cv. Diamante peel essential oils and identified active coumarins. Pharm Biol; 2010 Sep;48(9):1059-65
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  • In order to evaluate the cytotoxic activity two melanoma models, such as amelanotic melanoma C32 and malignant melanoma A375, were used.
  • This phototoxicity may be considered as a treatment option in some cases of lentigo maligna or lentigo maligna melanoma.
  • [MeSH-minor] Cell Line, Tumor. Cell Survival / drug effects. Cell Survival / radiation effects. Drug Discovery. Drug Evaluation, Preclinical. Gas Chromatography-Mass Spectrometry. Humans. Inhibitory Concentration 50. Melanoma / drug therapy. Melanoma, Amelanotic / drug therapy. Methoxsalen / analogs & derivatives. Methoxsalen / analysis. Methoxsalen / chemistry. Methoxsalen / pharmacology. Methoxsalen / radiation effects. Photochemotherapy. Phytotherapy. Time Factors. Ultraviolet Rays

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  • (PMID = 20690896.001).
  • [ISSN] 1744-5116
  • [Journal-full-title] Pharmaceutical biology
  • [ISO-abbreviation] Pharm Biol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Coumarins; 0 / Oils, Volatile; 4FVK84C92X / 5-methoxypsoralen; JWE1QQ247N / 5,7-dimethoxycoumarin; U4VJ29L7BQ / Methoxsalen
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92. Bapst JP, Calame M, Tanner H, Eberle AN: Glycosylated DOTA-alpha-melanocyte-stimulating hormone analogues for melanoma targeting: influence of the site of glycosylation on in vivo biodistribution. Bioconjug Chem; 2009 May 20;20(5):984-93
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  • [Title] Glycosylated DOTA-alpha-melanocyte-stimulating hormone analogues for melanoma targeting: influence of the site of glycosylation on in vivo biodistribution.
  • alpha-Melanocyte-stimulating hormone (alpha-MSH) is known to bind to the melanocortin receptor 1 (MC1R) which is overexpressed on melanotic and amelanotic melanoma cells. alpha-MSH analogues are potential candidates for specific targeting of melanoma metastases.
  • The peptides were evaluated in vitro for MC1R binding and bioactivity and, after labeling with (111)In, for in vitro cellular uptake and in vivo tissue distribution in mice carrying B16F1 melanoma tumors.
  • The glycopeptides showed excellent binding affinities in the low nanomolar to subnanomolar range using both murine and human melanoma cell lines.
  • [MeSH-major] Glycopeptides / metabolism. Glycopeptides / pharmacokinetics. Heterocyclic Compounds, 1-Ring / chemistry. Melanoma / metabolism. alpha-MSH / analogs & derivatives

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  • (PMID = 19388674.001).
  • [ISSN] 1520-4812
  • [Journal-full-title] Bioconjugate chemistry
  • [ISO-abbreviation] Bioconjug. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carbohydrates; 0 / Glycopeptides; 0 / Heterocyclic Compounds, 1-Ring; 0 / Peptide Fragments; 0 / Receptor, Melanocortin, Type 1; 0 / alpha-MSH (4-11), acetyl0Nle(4)-Asp(5)-Phe(7)-; 581-05-5 / alpha-MSH; 60239-18-1 / 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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93. Das P, Kumar N, Ahuja A, Jain A, Ray R, Sarkar C, Gupta SD: Primary malignant melanoma at unusual sites: an institutional experience with review of literature. Melanoma Res; 2010 Jun;20(3):233-9
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  • [Title] Primary malignant melanoma at unusual sites: an institutional experience with review of literature.
  • Apart from the skin and choroid plexus, primary malignant melanoma is rare at the other sites and lacks organized documentation.
  • Here, we have tried to enumerate the primary malignant melanomas at various atypical sites, supported by literature review.
  • Although many were amelanotic, no specific histology was noted.
  • In conclusion, malignant melanomas can arise in unconventional areas.
  • [MeSH-major] Melanoma / diagnosis. Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Genital Neoplasms, Female / diagnosis. Genital Neoplasms, Female / pathology. Humans. Immunohistochemistry / methods. Male. Medical Oncology / methods. Middle Aged. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 20386135.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 44
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94. Soucek P, Cihelkova I: Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment. Clin Exp Ophthalmol; 2006 Sep-Oct;34(7):721; author reply 721-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary treatment of choroidal amelanotic melanoma with photodynamic therapy--comment.
  • [MeSH-major] Choroid Neoplasms / drug therapy. Melanoma, Amelanotic / drug therapy. Photochemotherapy. Photosensitizing Agents / therapeutic use. Porphyrins / therapeutic use

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  • [CommentOn] Clin Exp Ophthalmol. 2005 Oct;33(5):548-9 [16181294.001]
  • (PMID = 16970777.001).
  • [ISSN] 1442-6404
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; 129497-78-5 / verteporfin
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95. Ludwig T, Fakih S, Bertram H, Krebs B, Oberleithner H: New imidazole-coordinated chemotherapeutics with low epithelial toxicity. Cell Biochem Biophys; 2006;45(1):31-41
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  • The chlorine substituted NICE had no effect on epithelial integrity but markedly cytotoxic activity against amelanotic melanoma cells.

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  • (PMID = 16679562.001).
  • [ISSN] 1085-9195
  • [Journal-full-title] Cell biochemistry and biophysics
  • [ISO-abbreviation] Cell Biochem. Biophys.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Imidazoles; 0 / Ligands; 0 / Organic Cation Transport Proteins; 0 / Organoplatinum Compounds; BG3F62OND5 / Carboplatin; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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96. Babilas P, Liebsch G, Schacht V, Klimant I, Wolfbeis OS, Szeimies RM, Abels C: In vivo phosphorescence imaging of pO2 using planar oxygen sensors. Microcirculation; 2005 Sep;12(6):477-87
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  • Due to intrinsically referencing via lifetime encoding there was no modification of the sensor response in vivo in the dorsal skinfold chamber model with amelanotic melanoma (A-MEL-3) in awake hamsters when compared to the in vitro calibration. pO(2) measurements over normal tissue (25.8 +/- 5.1 mm Hg) and tumor tissue (9.2 +/- 5.1 mm Hg) were in excellent agreement with previous results obtained in this model using a surface multiwire electrode.
  • [MeSH-major] Luminescent Measurements. Melanoma, Experimental / metabolism. Metalloporphyrins / analysis. Oximetry. Oxygen Consumption

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  • (PMID = 16147465.001).
  • [ISSN] 1073-9688
  • [Journal-full-title] Microcirculation (New York, N.Y. : 1994)
  • [ISO-abbreviation] Microcirculation
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Metalloporphyrins; 0 / Polystyrenes
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97. Mandato VD, Kobal B, Di Stefano A, Sinkovec J, Levicnik A, Rakar S, Costagliola L: Amelanotic malignant melanoma of the uterine cervix with ten-year follow-up. Eur J Gynaecol Oncol; 2009;30(1):106-9
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  • [Title] Amelanotic malignant melanoma of the uterine cervix with ten-year follow-up.
  • BACKGROUND: Malignant melanoma (MM) accounts for 3% of cancers that affect women and results in less than 1% of cancer deaths.
  • Fewer than ten cases of amelanotic MM (AMM) have been reported in literature.
  • CONCLUSION: Malignant melanoma of the cervix is often misdiagnosed because of non discriminatory features and the capacity to mimic other tumors.
  • Malignant melanoma of the cervix needs to be diagnosed as quickly as possible because a timely therapy and a long and careful follow-up might result in better survival.
  • [MeSH-major] Melanoma, Amelanotic / pathology. Skin Neoplasms / pathology. Uterine Cervical Neoplasms / pathology


98. Zamberk-Majlis P, Velázquez-Tarjuelo D, Avilés-Izquierdo JA, Lázaro-Ochaita P: [Dermoscopic characterization of 3 cases of fibroepithelioma of Pinkus]. Actas Dermosifiliogr; 2009 Dec;100(10):899-902
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  • [Transliterated title] Fibroepitelioma de Pinkus. Descripción dermatoscópica de 3 casos.
  • Clinical diagnosis often requires differentiation from benign lesions such as acrochordon, intradermal melanocytic nevus, neurofibroma, seborrheic keratosis, and even malignant lesions such as amelanotic melanoma.
  • Dermoscopy of this type of lesion is not extensively described in the literature, though it usually presents certain specific characteristics that suggest the diagnosis and, therefore, an appropriate therapeutic approach.
  • [MeSH-major] Carcinoma, Basal Cell / pathology. Dermoscopy. Skin Neoplasms / pathology

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  • (PMID = 20038369.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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99. Baran R: The red nail--always benign? Actas Dermosifiliogr; 2009 Nov;100 Suppl 1:106-13
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  • Red nail is a common disorder.
  • Only the former type can show histologically Bowen's disease or an amelanotic melanoma.
  • Subungual warty dyskeratoma is rare, but other dermatoses such as lichen planus, psoriasis, mail melanoma and various tumours have to be ruled out.

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  • (PMID = 20096204.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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100. Zerfas PM, Brinster LR, Starost MF, Burkholder TH, Raffeld M, Eckhaus MA: Amelanotic melanoma in a New Zealand White Rabbit (Oryctolagus cuniculus). Vet Pathol; 2010 Sep;47(5):977-81
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  • [Title] Amelanotic melanoma in a New Zealand White Rabbit (Oryctolagus cuniculus).
  • Positive staining with MART-1 (a melanocyte protein marker) combined with transmission electron microscopy revealing type II melanosomes confirmed the diagnosis of an amelanotic melanoma.
  • [MeSH-major] Facial Neoplasms / veterinary. Lymphatic Metastasis / pathology. Melanoma, Amelanotic / veterinary. Neoplasm Recurrence, Local / veterinary. Rabbits

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  • (PMID = 20460451.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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