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46. Stejskalová E, Jarosová M, Malis J, Sumerauer D, Urbánková H, Krsková L, Pýcha K, Schovanec J, Balcárková J, Smelhaus V, Kodetová D, Starý J: [Clinical relevance of chromosomal aberrations in bone and soft tissue tumors in children and young adults]. Klin Onkol; 2009;22(2):58-66
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  • [Title] [Clinical relevance of chromosomal aberrations in bone and soft tissue tumors in children and young adults].
  • BACKGROUND: We present the results of a cytogenetic and molecular cytogenetic analysis of a series of patients with bone and soft tissue tumors.
  • PATIENTS ANDMETHODS: We analyzed a cohort of 26 patients with Ewing sarcoma/PNET, 15 patients with rhabdomyosarcoma, 5 with synovial sarcoma and one patient with an undifferentiated sarcoma using the cytogenetic and molecular cytogenetic techniques M-FISH and arrayCGH.
  • In the RMS patients we detected the t(1;13)(p36;q14) once and the t(2;13)(q35;q14) four times, both of them characteristic for the alveolar subtype with poor prognosis and numerical aberrations, characteristic for the embryonal subtype, in five patients.
  • Four patients with synovial sarcoma had the diagnostic t(X;18)(p11.2;q11.2), one of them had a complex karyotype with a complex t(X;18;21) (p11.2;q11.2;q11.2) together with t(2;5)(q24-32;p13-14) and t(12;20)(p11;q13).
  • We correlated the karyotype of cancer cells with histopathologic morphologic analysis, clinical outcome and foreign published results.
  • CONCLUSION: Cytogenetic and molecular cytogenetic analysis is a valuable diagnostic tool in bone and soft tissue tumors, especially in less differentiated subtypes, and as such it should be an integral part of curative care.
  • [MeSH-major] Bone Neoplasms / genetics. Chromosome Aberrations. Soft Tissue Neoplasms / genetics

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  • (PMID = 19522375.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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47. Fernández-Recio J, Abagyan R, Totrov M: Improving CAPRI predictions: optimized desolvation for rigid-body docking. Proteins; 2005 Aug 1;60(2):308-13
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  • The ICM Docking and Interface Side-Chain Optimization (ICM-DISCO) showed promising predictive results during the first CAPRI experiment by successfully finding medium- or high-accuracy models in 3 of the 7 targets.
  • For that, we have defined a new desolvation descriptor for rigid-body docking, based on atomic solvation parameters (ASPs) derived from octanol-water transfer experiments.

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  • (PMID = 15981266.001).
  • [ISSN] 1097-0134
  • [Journal-full-title] Proteins
  • [ISO-abbreviation] Proteins
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Macromolecular Substances
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48. Goldstein M, Meller I, Issakov J, Orr-Urtreger A: Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. Neoplasia; 2006 May;8(5):332-43
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  • [Title] Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors.
  • Rhabdomyosarcoma, the most common pediatric soft tissue sarcoma, likely results from deregulation of the skeletal myogenesis program.
  • Using a combined approach of spectral karyotyping, array-based comparative genomic hybridization (CGH), and expression analysis, we examined 10 primary RMS tumors, including embryonal, alveolar, and the rare adult pleomorphic variant, to explore the involvement of different genes and genetic pathways in RMS tumorigenesis.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Genetic Predisposition to Disease. Neoplasms / genetics. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Alveolar / metabolism. Rhabdomyosarcoma, Embryonal / embryology. Rhabdomyosarcoma, Embryonal / genetics


49. McIntosh SA, Horgan K: Augmentation mammoplasty: effect on diagnosis of breast cancer. J Plast Reconstr Aesthet Surg; 2008;61(2):124-9
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  • [Title] Augmentation mammoplasty: effect on diagnosis of breast cancer.
  • In the USA in 2003, a total of 254 140 breast augmentation procedures were carried out [American Society of Plastic Surgeons, http://www.plasticsurgery.org/news_room/Procedural-Statistics-Press-Kit-Index.cfm9-1-2005; 2006.(1)].
  • However, as the population of women with breast implants ages, an increasing number of them will develop breast cancer; a reflection of the fact that the incidence of the disease increases with increasing age.
  • We review the literature on the radiological and tissue diagnosis of breast cancer in women with a history of previous augmentation mammaplasty.
  • [MeSH-major] Breast Implantation. Breast Neoplasms / diagnosis

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  • (PMID = 18039600.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 60
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50. Cantacessi C, Campbell BE, Young ND, Jex AR, Hall RS, Presidente PJ, Zawadzki JL, Zhong W, Aleman-Meza B, Loukas A, Sternberg PW, Gasser RB: Differences in transcription between free-living and CO2-activated third-stage larvae of Haemonchus contortus. BMC Genomics; 2010 Apr 27;11:266
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  • BACKGROUND: The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide.
  • RESULTS: Totals of 101,305 (L3) and 105,553 (xL3) expressed sequence tags (ESTs) were determined using 454 sequencing technology, and then assembled and annotated; the most abundant transcripts encoded transthyretin-like, calcium-binding EF-hand, NAD(P)-binding and nucleotide-binding proteins as well as homologues of Ancylostoma-secreted proteins (ASPs).
  • CONCLUSION: The present study indicated that some key transcriptional alterations taking place during the transition from the L3 to the xL3 stage of H. contortus involve genes predicted to be linked to the development of neuronal tissue (L3 and xL3), formation of the cuticle (L3) and digestion of host haemoglobin (xL3).

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  • (PMID = 20420710.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
  • [Other-IDs] NLM/ PMC2880303
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51. Armah HB, Parwani AV: Xp11.2 translocation renal cell carcinoma. Arch Pathol Lab Med; 2010 Jan;134(1):124-9
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  • These include a distinctive RCC that bears a translocation with the identical chromosomal breakpoints (Xp11.2, 17q25) and identical resulting ASPL-TFE3 gene fusion as alveolar soft part sarcoma.
  • [MeSH-minor] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Diagnosis, Differential. Humans. Oncogene Proteins, Fusion / genetics. Prognosis

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  • (PMID = 20073616.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
  • [Number-of-references] 30
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52. Shih PY, Wang T, Xing C, Sinha M, Song Y, Elston RC: Linkage analysis of alcohol dependence using both affected and discordant sib pairs. BMC Genet; 2005 Dec 30;6 Suppl 1:S36
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  • The basic idea of affected-sib-pair (ASP) linkage analysis is to test whether the inheritance pattern of a marker deviates from Mendelian expectation in a sample of ASPs.
  • To be robust to deviation from Mendelian transmission, here we analyzed Collaborative Study on the Genetics of Alcoholism data by modifying the ASP LOD score method to contrast the estimated distribution of the number of allele(s) shared IBD by ASPs with that by DSPs, instead of with the expected distribution under the Mendelian assumption.
  • This strategy assesses the difference in IBD sharing between ASPs and the IBD sharing between DSPs.

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  • (PMID = 16451646.001).
  • [ISSN] 1471-2156
  • [Journal-full-title] BMC genetics
  • [ISO-abbreviation] BMC Genet.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R37 GM028356; United States / NCRR NIH HHS / RR / P41 RR003655; United States / NIDDK NIH HHS / DK / DK-57292; United States / NCRR NIH HHS / RR / RR03655; United States / NIGMS NIH HHS / GM / GM28356; United States / NIDDK NIH HHS / DK / U01 DK057292; United States / NIGMS NIH HHS / GM / R01 GM028356
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC1866749
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53. Afshar AR, Abbasi F: Photoclinic. Primary alveolar soft part sarcoma of bone. Arch Iran Med; 2006 Apr;9(2):175-6, 181
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  • [Title] Photoclinic. Primary alveolar soft part sarcoma of bone.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Sarcoma, Alveolar Soft Part / surgery

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  • (PMID = 16649367.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
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5
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4. Rao PK, Missiaglia E, Shields L, Hyde G, Yuan B, Shepherd CJ, Shipley J, Lodish HF: Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells. FASEB J; 2010 Sep;24(9):3427-37
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  • Rhabdomyosarcoma is the most common soft tissue sarcoma in the pediatric population.
  • As this tumor has an undifferentiated myogenic phenotype, agents that promote differentiation hold particular promise as part of a novel therapeutic approach to combat this type of cancer.
  • Levels of miR-1 and miR-133a are drastically reduced in representative cell lines from each major rhabdomyosarcoma subtype (embryonal and alveolar).

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  • (PMID = 20466878.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK068348; United Kingdom / Cancer Research UK / / C5066/A9541
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs
  • [Other-IDs] NLM/ PMC3231107
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55. Wang ZH, Shi HY, Wang ZB: [Metastatic alveolar soft tissue sarcoma of the central nervous system: a clinicopathological analysis of four cases]. Ai Zheng; 2009 Nov;28(11):1214-8
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  • [Title] [Metastatic alveolar soft tissue sarcoma of the central nervous system: a clinicopathological analysis of four cases].
  • BACKGROUND AND OBJECTIVE: Metastatic alveolar soft tissue sarcoma (ASTS) of the central nervous system is rare and is easy to be misdiagnosed as other primary tumors of central nervous system.
  • This study was to analyze the clinical and pathological features of four patients with ASTS of the central nervous system and to clarify their differential diagnosis as well as prognosis.
  • The tumor cells had clear or eosinophilic cytoplasm and prominent nucleoli, arranged in alveolar structures, which were surrounded by delicate blood sinuses.
  • [MeSH-major] Cranial Fossa, Posterior. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / secondary. Skull Base Neoplasms / pathology. Skull Base Neoplasms / secondary
  • [MeSH-minor] Actins / metabolism. Adult. Desmin / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasm Recurrence, Local. Paraganglioma / diagnosis. Prognosis. Rhabdomyosarcoma / diagnosis. S100 Proteins / metabolism. Survival Rate

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  • (PMID = 19895745.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins
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56. Liu PJ, Hsieh WT, Huang SH, Liao HF, Chiang BH: Hematopoietic effect of water-soluble polysaccharides from Angelica sinensis on mice with acute blood loss. Exp Hematol; 2010 Jun;38(6):437-45
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  • MATERIALS AND METHODS: The crude extract of Angelica sinensis (AS) was separated into two fractions, polysaccharides (ASPS) and small molecular weight compounds.
  • The AS, ASPS, and small molecular weight compounds were incubated with mice spleen cells to obtain conditioned mediums, and then their hematopoietic activities were evaluated by granulocyte macrophage (GM) colony-forming assay in vitro.
  • RESULTS: We found that polysaccharide (ASPS) was the major component responsible for the hematopoietic effect of Angelica sinensis.
  • Administration of low-dose ASPS (2.3 mg ASPS/kg body weight per day) could significantly accelerate the recovery of hemoglobin level of the blood-loss mice to its original value, as compared to the control (p < 0.05).
  • Moreover, the colony-forming ability of bone marrow cells that were removed from mice that received ASPS was also markedly increased (p < 0.05) during ex vivo test.
  • CONCLUSIONS: Results of this study demonstrated the potential of ASPS for treatment of anemia.

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  • [Copyright] Copyright 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20347925.001).
  • [ISSN] 1873-2399
  • [Journal-full-title] Experimental hematology
  • [ISO-abbreviation] Exp. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / Hematopoietic Cell Growth Factors; 0 / Plant Extracts; 0 / Polysaccharides; 059QF0KO0R / Water
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57. Linardic CM, Naini S, Herndon JE 2nd, Kesserwan C, Qualman SJ, Counter CM: The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence. Cancer Res; 2007 Jul 15;67(14):6691-9
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  • Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence.
  • Despite advances in therapy, patients with a histologic variant of rhabdomyosarcoma known as alveolar rhabdomyosarcoma (ARMS) have a 5-year survival of <30%.
  • This association between PAX3-FKHR expression and p16(INK4A) loss was seen in human ARMS tumor tissue, as both human rhabdomyosarcoma cell lines and tissue microarrays showed a trend toward down-regulation of p16(INK4A) protein in alveolar subsets.

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  • (PMID = 17638879.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12 HD043494; United States / NICHD NIH HHS / HD / 5K12 HD 043494; United States / NCI NIH HHS / CA / R01 CA 94184
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / FOXO1 protein, human; 0 / Forkhead Box Protein O1; 0 / Forkhead Transcription Factors; 0 / PAX3 Transcription Factor; 0 / PAX3 protein, human; 0 / Paired Box Transcription Factors; 0 / Recombinant Fusion Proteins
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58. Mentzel T, Kuhnen C: Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch; 2006 Nov;449(5):554-60
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  • Rhabdomyosarcoma (RMS) is currently classified into embryonal RMS, including its botryoid and spindle cell variants, alveolar RMS, including a solid variant, and pleomorphic RMS.
  • In children and adolescents embryonal RMS occurs in a younger age group than alveolar RMS, and pleomorphic RMS is almost always seen in older adults.
  • All neoplasms arose in subcutaneous and deep soft tissues with dermal involvement in one case, and the size of the neoplasms ranged from 4 to 19 cm in largest diameter.
  • Follow-up information was available in five patients (range from 10 to 48 months) and revealed lung metastases in two patients who died of disease within a short period.
  • Immunohistochemically, tumour cells in RMS stain positively for CD 99 and WT1 as well, which is of importance in the differential diagnosis to other mesenchymal neoplasms, whereas fast myosin does not represent a reliable marker for RMS in adults.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17013628.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
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59. Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C: Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res; 2009 Apr 1;69(7):2902-11
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  • [Title] Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.
  • The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma of childhood, yet the outcome for the unresectable and metastatic disease is dismal and unchanged for nearly three decades.
  • To better understand the pathogenesis of this disease and to facilitate novel preclinical approaches, we previously developed a conditional mouse model of ARMS by faithfully recapitulating the genetic mutations observed in the human disease, i.e., activation of Pax3:Fkhr fusion gene with either p53 or Cdkn2a inactivation.
  • In this report, we show that this model recapitulates the immunohistochemical profile and the rapid progression of the human disease.

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  • (PMID = 19339268.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA074907-06; United States / NCI NIH HHS / CA / CA090438-06; United States / NCI NIH HHS / CA / CA064202-07; United States / NCI NIH HHS / CA / CA064202-13; United States / NCI NIH HHS / CA / R01 CA064202-08S1; United States / NCI NIH HHS / CA / P30CA54174; United States / NCI NIH HHS / CA / R01 CA064202-11; United States / NCI NIH HHS / CA / CA064202-08S1; United States / NCI NIH HHS / CA / R01 CA074907-09; United States / NCI NIH HHS / CA / K08 CA090438; United States / NCI NIH HHS / CA / CA074907-11; United States / NCI NIH HHS / CA / CA64202; United States / NCI NIH HHS / CA / R01 CA064202-06; United States / NCI NIH HHS / CA / R01 CA074907; United States / NCI NIH HHS / CA / CA064202-08; United States / NCI NIH HHS / CA / CA074907-07; United States / NCI NIH HHS / CA / R01 CA064202-14; United States / NCI NIH HHS / CA / R01 CA064202-13; United States / NCI NIH HHS / CA / R01 CA064202-07; United States / NCI NIH HHS / CA / R29 CA074907; United States / NCI NIH HHS / CA / CA074907-08; United States / NCI NIH HHS / CA / R01 CA064202-09; United States / NCI NIH HHS / CA / R01 CA064202; United States / NCI NIH HHS / CA / CA074907; United States / NCI NIH HHS / CA / CA074907-10A1; United States / NCI NIH HHS / CA / CA064202-11; United States / NCI NIH HHS / CA / CA074907-09; United States / NCI NIH HHS / CA / CA074907-06; United States / NCI NIH HHS / CA / R01 CA064202-08; United States / NCI NIH HHS / CA / R01 CA074907-11; United States / NCI NIH HHS / CA / CA064202-14; United States / NCI NIH HHS / CA / CA064202-10A1; United States / NCI NIH HHS / CA / R01 CA074907-07; United States / NCI NIH HHS / CA / P30 CA054174; United States / NCI NIH HHS / CA / CA064202-12; United States / NCI NIH HHS / CA / R01 CA074907-08; United States / NCI NIH HHS / CA / CA064202-06; United States / NCI NIH HHS / CA / R01 CA064202-12; United States / NCI NIH HHS / CA / K08 CA090438-06; United States / NCI NIH HHS / CA / R01 CA064202-10A1; United States / NCI NIH HHS / CA / CA064202-09; United States / NCI NIH HHS / CA / R01 CA074907-10A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Forkhead Transcription Factors; 0 / Foxo1 protein, mouse; 0 / Oncogene Proteins, Fusion; 0 / PAX3-FKHR fusion protein, human; 0 / Paired Box Transcription Factors; 0 / Tumor Suppressor Protein p53; 138016-91-8 / Pax3 protein, mouse
  • [Other-IDs] NLM/ NIHMS96027; NLM/ PMC2789740
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60. Rohrich RJ: The 10-year American Society of Plastic Surgeons' history update. Plast Reconstr Surg; 2006 Oct;118(5 Suppl):1S
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The 10-year American Society of Plastic Surgeons' history update.
  • [MeSH-major] Societies, Medical / history. Surgery, Plastic

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  • (PMID = 17006312.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Editorial; Historical Article
  • [Publication-country] United States
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61. Okoro SA, Barone C, Bohnenblust M, Wang HT: Breast reduction trend among plastic surgeons: a national survey. Plast Reconstr Surg; 2008 Nov;122(5):1312-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast reduction trend among plastic surgeons: a national survey.
  • The authors' goal was to survey members of the American Society of Plastic Surgeons to identify their preferences and practices and report their opinion regarding issues related to the various breast reduction techniques.
  • METHODS: In the fall of 2006, a one-page anonymous survey was sent to 5112 plastic surgeons who were members of the American Society of Plastic Surgeons.
  • RESULTS: Of the 5112 plastic surgeons surveyed, 2665 (52 percent) responded to the survey.
  • Plastic surgeons are becoming more cognizant of the risk of deep venous thrombosis among their patients.
  • [MeSH-major] Mammaplasty / trends. Professional Practice / trends. Surgery, Plastic / trends

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  • (PMID = 18971713.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Villani F, Caviggioli F, Giannasi S, Klinger M, Klinger F: Current applications and safety of autologous fat grafts: a report of the ASPS Fat Graft Task Force. Plast Reconstr Surg; 2010 Feb;125(2):758-9; author reply 759
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  • [Title] Current applications and safety of autologous fat grafts: a report of the ASPS Fat Graft Task Force.
  • [MeSH-major] Adipose Tissue / transplantation. Evidence-Based Medicine. Practice Guidelines as Topic. Reconstructive Surgical Procedures / standards. Surgery, Plastic / standards

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  • [CommentOn] Plast Reconstr Surg. 2009 Jul;124(1):272-80 [19346997.001]
  • (PMID = 20124871.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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63. Lazar AJ, Lahat G, Myers SE, Smith KD, Zou C, Wang WL, Lopez-Terrada D, Lev D: Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray. Histopathology; 2009 Dec;55(6):750-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray.
  • AIMS: The molecular signature of alveolar soft part sarcoma (ASPS) is a specific der(17)t(X;17)(p11.2;q25) translocation, resulting in a chimeric transcription factor (ASPSCR1-TFE3).
  • When this disease is no longer amenable to surgical curative intervention, uniformly efficacious therapies are lacking.
  • The aim of this study was to evaluate the expression of potential molecular therapeutic targets in a cohort of ASPS tumour samples.
  • METHODS AND RESULTS: Immunohistochemical analysis for hepatocyte growth factor, c-Met, phosphorylated c-Met, phosphorylated AKT, phosphorylated MEK, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), p53 and vimentin was performed on an ASPS tissue microarray, yielding complete data from 26 tumours.
  • CONCLUSIONS: There is a crucial need for better anti-ASPS therapies.
  • [MeSH-major] Neoplasm Proteins / metabolism. Sarcoma, Alveolar Soft Part / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Tissue Array Analysis


64. Miron I, Miron L, Dumitraş S, Aprodu G, Ciobanu A, Tansanu I: [Statistical study of the evolution over ten years of the clinical and therapeutic approach in childhood soft tissue sarcoma]. Rev Med Chir Soc Med Nat Iasi; 2007 Apr-Jun;111(2):358-62
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  • [Title] [Statistical study of the evolution over ten years of the clinical and therapeutic approach in childhood soft tissue sarcoma].
  • [Transliterated title] Studiul statistic clinico-terapeutic si evolutiv pe 10 ani in sarcoamele de tesuturi moi la copii si tineri.
  • Soft tissue sarcoma has a primitive mesenchymal origin and represents a heterogeneous group of malignant entities with a continuous rising frequency in the age range below 18.
  • We included in the study a well-known category of soft tissue tumors called of uncertain malignancy.
  • Maria" Clinical Emergency Hospital Iaşi on a group of 58 de patients ranging between 0 and 18 years old.
  • Based on histological examination 19 cases (32.75%) were of rhabdomyosarcoma type with following subtypes: alveolar--7 patients, embryonic-- 9 cases, fusiform - 2 cases, bothrioid--1 case), 8 cases were undifferentiated soft tissue sarcomas and one patient had a tumor of pleiomorphic type; 13 children (22.41%) had non-rhabdomyosarcoma soft tissue sarcomas: 6 fibrosarcomas, 2 synovial sarcomas, 1 leiomyosarcoma, 1 Kaposi sarcoma, 1 case of malignant peripheral nerve sheath tumor, 1 case of angioma tumor, one liposarcoma; 16 cases were included in soft tissue tumors of uncertain origin (fibromatosis--6 cases, fibrous histiocytoma--4 cases, hamartoma--cases, myoblastoma--1 case, fibro-xanthoma--1 case, hemangioendothelioma--1 case); 1 PPNET (Askin tumor).
  • CONCLUSIONS: The continuously augmented incidence of soft tissue sarcoma in young ages and the advanced stages initial presentations of tumors require a much more serious and rhythmic survey at general practitioner level.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / therapy. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / therapy

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  • (PMID = 17983168.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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65. Thway K, Rockcliffe S, Gonzalez D, Swansbury J, Min T, Thompson L, Fisher C: Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre. J Clin Pathol; 2010 Jun;63(6):508-12
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  • [Title] Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre.
  • AIMS: Diagnosis of soft tissue sarcomas can be difficult.
  • This study assessed the utility of a molecular genetics/cytogenetics service as part of the routine diagnostic service at the Royal Marsden Hospital.
  • METHODS: A retrospective audit was performed over a 15-month period to evaluate the diagnostic usefulness for soft tissue sarcomas with translocations of fluorescence in situ hybridisation (FISH) and reverse-transcriptase PCR (RT-PCR) in paraffin-embedded (PE) material.
  • RESULTS: Molecular investigations were performed on PE material in 158 samples (total 194 RT-PCR and 174 FISH tests), of which 85 were referral cases.
  • Synovial sarcoma, Ewing sarcoma and low-grade fibromyxoid sarcoma were the most commonly tested tumours.
  • Myxoid liposarcoma showed the best histological and molecular concordance, and alveolar rhabdomyosarcoma showed the best agreement between methods.
  • FISH had a higher sensitivity for detecting tumours (73%, compared with 59% for RT-PCR) with a better success rate than RT-PCR, although the latter was specific in identifying the partner gene for each fusion.
  • In particular, referral blocks in which methods of tissue fixation and processing were not certain resulted in higher RT-PCR failure rates.
  • CONCLUSIONS: FISH and RT-PCR on PE tissue are practical and effective ancillary tools in the diagnosis of soft tissue sarcomas.
  • PCR is less sensitive than FISH, and the use of both techniques is optimal for maximising the detection rate of translocation-positive sarcomas.
  • [MeSH-major] Oncogene Fusion. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Epidemiologic Methods. Humans. In Situ Hybridization, Fluorescence / methods. Paraffin Embedding. Reverse Transcriptase Polymerase Chain Reaction / methods. Translocation, Genetic


66. Aulmann S, Longerich T, Schirmacher P, Mechtersheimer G, Penzel R: Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. Histopathology; 2007 Jun;50(7):881-6
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  • [Title] Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.
  • AIMS: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, non-reciprocal translocation der(17)t(X;17)(p11.2;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TFE3.
  • Although diagnosis is straightforward in classical cases, tumours with atypical morphological features may be difficult to classify solely on the basis of conventional histopathology.
  • The aim of this study was to analyse the chromosomal breakpoints in paraffin-embedded tissue.
  • METHODS AND RESULTS: Three male and two female ASPS patients including one case with uncommon histology were investigated by fluorescence in situ hybridization with split- and fusion-probes.
  • Hybridization results showed a t(X;17)(p11.2;q25) in all tumours with a duplication of the telomeric part of chromosome Xp.
  • CONCLUSIONS: Molecular confirmation of ASPSCR1-TFE3 gene fusion is applicable to routinely processed archival and diagnostic tumour samples and aids in the differential diagnosis of ASPS.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Neoplasm Proteins / genetics. Oncogene Fusion. Oncogene Proteins, Fusion / genetics. Sarcoma, Alveolar Soft Part / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 17543078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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67. Khanna P, Paidas CN, Gilbert-Barness E: Alveolar soft part sarcoma: clinical, histopathological, molecular, and ultrastructural aspects. Fetal Pediatr Pathol; 2008;27(1):31-40
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  • [Title] Alveolar soft part sarcoma: clinical, histopathological, molecular, and ultrastructural aspects.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor occurring mainly in the adolescents and young adults.
  • The histopathological, ultrastructural, immunohistochemical, and genetic aspects of ASPS are discussed.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18568987.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / S100 Proteins; 0 / Synaptophysin
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68. Morris WR, Padgett DM, Osborn FD, Fleming JC: Pathologic quiz case: an orbital mass in a 45-year-old woman. Alveolar soft part sarcoma. Arch Pathol Lab Med; 2005 Apr;129(4):534-6
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  • [Title] Pathologic quiz case: an orbital mass in a 45-year-old woman. Alveolar soft part sarcoma.
  • [MeSH-major] Orbital Neoplasms / pathology. Sarcoma, Alveolar Soft Part / pathology

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  • (PMID = 15794682.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Kebudi R, Ayan I, Görgün O, Ağaoğlu FY, Vural S, Darendeliler E: Brain metastasis in pediatric extracranial solid tumors: survey and literature review. J Neurooncol; 2005 Jan;71(1):43-8
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  • The diagnosis was sarcomas in 12 patients: 5 osteosarcomas, 4 Ewing's sarcoma family tumors, 1 rhabdomyosarcoma, 1 clear cell sarcoma of the soft tissue, 1 alveolar soft part sarcoma.
  • Four patients (25%) had brain metastasis at diagnosis.
  • Twelve (75%) developed brain metastasis during therapy or relapse at a median duration of 16 (1-70) months from initial diagnosis.
  • Treatment included surgery, followed by postoperative radiotherapy (RT) and chemotherapy (CT) in 1, S and RT in 1, S in 1, RT and CT in 6, RT in 1, CT in 1 and no treatment in 5.
  • Only one patient with alveolar soft part sarcoma is alive with disease 20 months from diagnosis of brain metastasis.
  • Although, the outcome for these patients is dismal in this series and in the literature; reports of long term survival in a few cases with Wilms' tumor, osteosarcoma and alveolar soft part sarcoma who had isolated brain metastasis, suggest that a subset of patients may benefit from therapy.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / secondary. Sarcoma / epidemiology. Sarcoma / secondary

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  • (PMID = 15719274.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 43
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70. D'Amico RA, Saltz R, Rohrich RJ, Kinney B, Haeck P, Gold AH, Singer R, Jewell ML, Eaves F 3rd: Risks and opportunities for plastic surgeons in a widening cosmetic medicine market: future demand, consumer preferences, and trends in practitioners' services. Plast Reconstr Surg; 2008 May;121(5):1787-92
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  • [Title] Risks and opportunities for plastic surgeons in a widening cosmetic medicine market: future demand, consumer preferences, and trends in practitioners' services.
  • BACKGROUND: The American Society of Plastic Surgeons and the American Society for Aesthetic Plastic Surgery launched a joint Cosmetic Medicine Task Force to address the growing trend of non-plastic surgeons entering the cosmetic medicine field.
  • The task force commissioned two surveys in 2007 to determine consumer attitudes about choosing cosmetic medicine providers and to learn about the cosmetic services that plastic surgeons offer.
  • RESULTS: Compared with other practitioners, plastic surgeons enjoy higher rates of satisfaction among their patients who undergo noninvasive procedures.
  • Injectables present a particularly promising market for plastic surgeons.
  • Half of consumers surveyed said they were very concerned about complications associated with injectables, and generally, the higher the perceived risk of the procedure, the higher the likelihood that a patient would choose a plastic surgeon to perform it.
  • However, almost half of consumers said that if they had a positive experience with a non-plastic surgeon core provider for a noninvasive procedure, that physician would likely be their first choice for a surgical procedure.
  • CONCLUSIONS: These findings suggest that plastic surgeons, and especially those who are building young practices, must expand their offerings of nonsurgical cosmetic services to remain at the core of the cosmetic medicine field.
  • [MeSH-major] Consumer Behavior. Delivery of Health Care / trends. Health Services Needs and Demand / trends. Marketing of Health Services / trends. Surgery, Plastic / trends

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  • (PMID = 18454004.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Hoshino M, Ogose A, Kawashima H, Izumi T, Hotta T, Hatano H, Morita T, Otsuka H, Umezu H, Yanoma S, Tsukuda M, Endo N: Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma. Cancer Genet Cytogenet; 2009 Apr 15;190(2):75-80
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  • [Title] Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a distinct, rare soft tissue tumor with an unknown histogenesis and a tendency for late widespread metastases to lung, bone, and brain.
  • It is now clear that they are caused by a specific unbalanced translocation, der(17)t(X;17)(p11;q25), which results in the formation of an ASPSCR1-TFE3 (alias ASPL-TFE3) fusion gene.
  • The rearrangement results in the expression of chimeric transcripts, which can be identified by means of reverse transcriptase-polymerase chain reaction (RT-PCR).
  • We investigated the histogenesis of ASPS and attempted to detect circulating ASPS tumor cells in peripheral blood.
  • The immunohistochemical and genetic details of four cases and one cell line of ASPS were examined.
  • An immunohistochemical analysis and RT-PCR did not detect myogenic differentiation gene MYOD1.
  • The sensitivity of nested RT-PCR for detection of circulating ASPS cells was assessed by demonstrating that the tumor cell-associated gene translocation could be detected in 50 tumor cells/2 mL of blood.
  • Clinically, it was detectable in a peripheral blood sample (2 mL) of ASPS patient with distant metastases.
  • The findings suggest that ASPS is not of skeletal muscle origin.
  • ASPS tumor cells in the peripheral blood could be monitored by RT-PCR.
  • [MeSH-major] Neoplastic Cells, Circulating. Sarcoma, Alveolar Soft Part / pathology

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  • (PMID = 19380023.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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72. Roma AA, Yang B, Senior ME, Goldblum JR: TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report. Int J Gynecol Pathol; 2005 Apr;24(2):131-5
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  • [Title] TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report.
  • SUMMARY: : Alveolar soft part sarcoma (ASPS) is an uncommon neoplasm that has only rarely been reported in the female genital tract.
  • We report a case of incidentally discovered ASPS in the uterine cervix of a 39-year-old woman that exhibited immunoreactivity for TFE3, a recently described marker of ASPS.
  • Strong nuclear immunoreactivity for TFE3 in tumors characterized by a chromosomal translocation involving the TFE3 gene has been reported in ASPS and a subset of pediatric renal cell carcinomas.
  • To the best of our knowledge, this is the first report of ASPS of the female genital tract with immunoreactivity for TFE3.
  • [MeSH-major] Biomarkers, Tumor / analysis. DNA-Binding Proteins / metabolism. Sarcoma, Alveolar Soft Part / pathology. Transcription Factors / metabolism. Uterine Neoplasms / pathology

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  • (PMID = 15782069.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TFE3 protein, human; 0 / Transcription Factors
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73. Huh WW, Skapek SX: Childhood rhabdomyosarcoma: new insight on biology and treatment. Curr Oncol Rep; 2010 Nov;12(6):402-10
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  • Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood.
  • The two most common histologic variants are the embryonal and alveolar subtypes.
  • Although successive collaborative group clinical trials have improved survival rates for many RMS patients, the outcome for those patients with metastatic or recurrent disease remains poor.
  • Recent studies have pointed to a possible mesenchymal stem cell as the progenitor for alveolar RMS.
  • [MeSH-major] Rhabdomyosarcoma, Alveolar / diagnosis. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Alveolar / therapy. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / genetics. Rhabdomyosarcoma, Embryonal / therapy. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Animals. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Child. Child, Preschool. Clinical Trials as Topic. Combined Modality Therapy. Disease Progression. Female. Humans. Male. Mesenchymal Stromal Cells / pathology. Mice. Neoplasm Metastasis. Neoplasm Staging. Neoplastic Stem Cells / metabolism. Neoplastic Stem Cells / pathology. Prognosis. Protein Kinase Inhibitors / administration & dosage. Risk Factors. Secondary Prevention. Signal Transduction / drug effects. Signal Transduction / genetics. Sirolimus / administration & dosage. Survival Rate. TOR Serine-Threonine Kinases / antagonists & inhibitors. Tomography

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  • (PMID = 20820958.001).
  • [ISSN] 1534-6269
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; EC 2.7.1.1 / TOR Serine-Threonine Kinases; W36ZG6FT64 / Sirolimus
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74. Zhu FP, Lu GM, Zhang LJ, Wang JD, An XJ, Dong YC: Primary alveolar soft part sarcoma of vertebra: a case report and literature review. Skeletal Radiol; 2009 Aug;38(8):825-9
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  • [Title] Primary alveolar soft part sarcoma of vertebra: a case report and literature review.
  • Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor, which rarely occurs in bone.
  • We present a case of ASPS in a 23-year-old man with a 2-month history of back pain.
  • Computed tomography scanning and magnetic resonance images demonstrated a destructive process in the 12th thoracic vertebra associated with a unilateral soft tissue mass.
  • The tumor showed evidence of hypervascularity on MRI; it obviously was enhanced on T1-weighted images after injection of Gd-GDPA, and signal voids were shown on all pulse sequences which may help to differentiate ASPS from other tumors of the vertebra.
  • We believe that this is the first case of ASPS arising in a vertebra.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Magnetic Resonance Imaging / methods. Spinal Neoplasms / diagnosis. Thoracic Vertebrae / diagnostic imaging. Thoracic Vertebrae / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 19347336.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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75. Tang Z, Mallikaratchy P, Yang R, Kim Y, Zhu Z, Wang H, Tan W: Aptamer switch probe based on intramolecular displacement. J Am Chem Soc; 2008 Aug 27;130(34):11268-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Both of these ASPs presented excellent selectivity and prompt response toward their targets.

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  • (PMID = 18680291.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aptamers, Nucleotide; 0 / DNA Probes; 0 / DNA, Complementary; 0 / Fluorescent Dyes; 30IQX730WE / Polyethylene Glycols; 8L70Q75FXE / Adenosine Triphosphate; 9007-49-2 / DNA; EC 3.4.21.5 / Thrombin
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76. Campbell B, Seymour JF, Wheeler G, Sexton M: Alveolar soft-part sarcoma: a cardiac metastasis as a rare site of relapse. Am J Clin Oncol; 2006 Aug;29(4):422-3
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  • [Title] Alveolar soft-part sarcoma: a cardiac metastasis as a rare site of relapse.
  • [MeSH-major] Heart Neoplasms / secondary. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 16891875.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Kohashi K, Oda Y, Yamamoto H, Tamiya S, Takahira T, Takahashi Y, Tajiri T, Taguchi T, Suita S, Tsuneyoshi M: Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype. J Cancer Res Clin Oncol; 2008 Oct;134(10):1097-103
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  • [Title] Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype.
  • PURPOSE: Rhabdomyosarcoma (RMS), which is the most common pediatric soft tissue sarcoma, is classified into two major histologic subtypes, embryonal RMS (ERMS) and alveolar RMS (ARMS).
  • In addition, immunohistochemical pRB LI may have the potential to be a useful ancillary tool in the differential diagnosis of RMS subtypes.
  • [MeSH-major] Retinoblastoma Protein / biosynthesis. Retinoblastoma Protein / genetics. Rhabdomyosarcoma, Alveolar / diagnosis. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / genetics
  • [MeSH-minor] Base Sequence. Diagnosis, Differential. Gene Expression. Humans. Immunohistochemistry. Mutation. Reverse Transcriptase Polymerase Chain Reaction


78. Baglam T, Kalender ME, Durucu C, Bakir K, Karatas E, Kara F, Kanlikama M: Alveolar soft part sarcoma of the tongue. J Craniofac Surg; 2009 Nov;20(6):2160-2
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  • [Title] Alveolar soft part sarcoma of the tongue.
  • Alveolar soft part sarcoma is a rare type of sarcoma that usually affects young adult women.
  • Herein, we present an unusual case of alveolar soft part sarcoma of the tongue in an 18-year-old woman.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Tongue Neoplasms / pathology

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  • (PMID = 19884839.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Messieha Z, Cruz-Gonzalez W, Hakim MI: Retrospective outcomes evaluation of 100 parenteral moderate and deep sedations conducted in a general practice dental residency. Anesth Prog; 2008;55(4):116-20
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  • An abstract of this study was presented at the American Association for Dental Research (AADR) Dental Anesthesiology Research Group in Honolulu, Hawaii, in March of 2004.
  • This study was conducted to correlate the intraoperative and postoperative morbidity associated with moderate and deep sedation, also known as monitored anesthesia care (MAC), provided in a General Practice Residency (GPR) clinic under the supervision of a dentist anesthesiologist.
  • Eleven morbidity criteria were assessed and were correlated with patient age, gender, American Society of Anesthesiology Physical Status Classification (ASAPS), duration of procedure, and anesthetic protocol.
  • No ASPS IV or V was noted.

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  • (PMID = 19108595.001).
  • [ISSN] 0003-3006
  • [Journal-full-title] Anesthesia progress
  • [ISO-abbreviation] Anesth Prog
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Dissociative; 0 / Anesthetics, Intravenous; 0 / Antiemetics; 4AF302ESOS / Ondansetron; 690G0D6V8H / Ketamine; R60L0SM5BC / Midazolam; YI7VU623SF / Propofol
  • [Other-IDs] NLM/ PMC2614649
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80. Biernacka JM, Cordell HJ: Exploring causality via identification of SNPs or haplotypes responsible for a linkage signal. Genet Epidemiol; 2007 Nov;31(7):727-40
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  • In a small chromosomal region, a number of polymorphisms may be both linked to and associated with a disease.
  • Recently, several methods have been proposed to aid in the identification of disease associated polymorphisms that may explain an observed linkage signal, using genotype data from affected sib pairs (ASPs) [Li et al. [2005] Am. J. Hum. Genet.
  • We extend variations of these methods to test for complete LD between a disease locus and haplotypes composed of two or more tightly linked candidate SNPs.
  • We study properties of the proposed methods by simulation and apply them to type 1 diabetes data for ASPs and their parents at candidate SNP and microsatellite marker loci in the Insulin (INS) gene region.

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  • (PMID = 17508343.001).
  • [ISSN] 0741-0395
  • [Journal-full-title] Genetic epidemiology
  • [ISO-abbreviation] Genet. Epidemiol.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 074524
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin
  • [Other-IDs] NLM/ PMC2682330
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81. Suvilampi J, Lehtomäki A, Rintala J: Comparative study of laboratory-scale thermophilic and mesophilic activated sludge processes. Water Res; 2005 Mar;39(5):741-50
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  • Laboratory-scale mesophilic (20-35 degrees C) and thermophilic (55 degrees C) activated sludge processes (ASPs) treating diluted molasses wastewater were compared in effluent quality, removal of different COD fractions, sludge yield, floc size, and sludge settleability.
  • In the ASPs, the hydraulic retention time was 12h in both processes, corresponding to a volumetric loading rate of 3.2+/-1.0 kg COD(filt) m(-3)d(-1).
  • Both ASPs gave high (90%) COD(sol) removals.

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  • (PMID = 15743618.001).
  • [ISSN] 0043-1354
  • [Journal-full-title] Water research
  • [ISO-abbreviation] Water Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sewage; 1327-41-9 / aluminum oxychloride; 5QB0T2IUN0 / Aluminum Hydroxide; S88TT14065 / Oxygen
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82. Tanas MR, Rubin BP, Tubbs RR, Billings SD, Downs-Kelly E, Goldblum JR: Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience. Arch Pathol Lab Med; 2010 Dec;134(12):1797-803
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  • [Title] Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience.
  • OBJECTIVE: To determine the utility of FISH in the diagnosis of mesenchymal neoplasms.
  • DESIGN: Two hundred thirty soft tissue cases analyzed by FISH were reviewed retrospectively.
  • RESULTS: Morphologic patterns where FISH was used included high-grade round cell sarcomas (n  =  67), nonmyogenic spindle cell sarcomas (n  =  40), low-grade myxoid neoplasms (n  =  34), adipocytic neoplasms (n  =  20), and melanocytic neoplasms (n  =  19).
  • SYT FISH (96% of monophasic synovial sarcomas were positive; 0% of malignant peripheral nerve sheath tumor were positive) and DDIT3 FISH (100% of myxoid/round cell liposarcomas; no other neoplasm positive) were very sensitive and specific.
  • EWSR1 FISH was very sensitive and specific in the differential diagnosis of melanocytic neoplasms (88% of clear cell sarcomas were positive; all melanomas were negative).
  • EWSR1 FISH was sensitive among high-grade round cell sarcomas (positive in 100% of desmoplastic small round cell tumors and 96% of Ewing sarcoma/primitive neuroectodermal tumors) but not specific because clear cell sarcoma, extraskeletal myxoid chondrosarcoma, and a subset of round cell liposarcomas also harbor rearrangements of EWSR1.
  • FUS FISH was very sensitive in detecting low-grade fibromyxoid sarcomas (91% positive) but not specific because most myxoid/round cell liposarcomas also contain rearrangements of FUS.
  • FOXO1A FISH was positive in ∼70% of cases of alveolar rhabdomyosarcoma.
  • CONCLUSION: FISH is a useful adjunct in the diagnosis of mesenchymal neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Melanoma / diagnosis. Neoplasms, Adipose Tissue / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis


83. Lin YY, Hsieh TC, Kao CH, Wang CH, Wu YC, Yen KY, Sun SS: Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma. Clin Nucl Med; 2009 Nov;34(11):806-7
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  • [Title] Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / radionuclide imaging. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / radionuclide imaging

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  • (PMID = 19851182.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Stachowski J, Botts K, Rine L, Kato D, Pollock J: Mesotherapy: cosmetic applications. Int J Pharm Compd; 2006 Sep-Oct;10(5):331-4
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  • Mainly owing to the absence of safety and efficacy data pertaining to mesotherapy, liposuction is currently the only method for fat removal that is endorsed by the American Society of Plastic Surgeons .

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  • (PMID = 23974310.001).
  • [ISSN] 1092-4221
  • [Journal-full-title] International journal of pharmaceutical compounding
  • [ISO-abbreviation] Int J Pharm Compd
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Drew RH: Antimicrobial stewardship programs: how to start and steer a successful program. J Manag Care Pharm; 2009 Mar;15(2 Suppl):S18-23
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  • BACKGROUND: Antimicrobial stewardship programs (ASPs) promote the appropriate use of antimicrobials by selecting the appropriate dose, duration, and route of administration.
  • Other supplemental strategies involve education, guidelines and clinical pathways, antimicrobial order forms, de-escalation of therapy, intravenous-to-oral (IV-to-PO) switch therapy, and dose optimization.
  • Several barriers exist to successful implementation of ASPs.
  • CONCLUSION: ASPs have the potential to reduce antimicrobial resistance, health care costs, and drug-related adverse events while improving clinical outcomes.
  • The efforts and expense required to implement and maintain ASPs are more than justified given their potential benefits to both the hospital and the patient.


86. Hallock GG, Hallock EA: The Venus de Milo: an icon of reconstructive surgery and the American Society of Plastic Surgeons. Plast Reconstr Surg; 2005 Jun;115(7):2074-9
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  • [Title] The Venus de Milo: an icon of reconstructive surgery and the American Society of Plastic Surgeons.
  • [MeSH-major] Emblems and Insignia. Sculpture. Societies, Medical. Surgery, Plastic

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  • (PMID = 15923858.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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87. Sidi V, Fragandrea I, Hatzipantelis E, Kyriakopoulos C, Papanikolaou A, Bandouraki M, Koliouskas DE: Alveolar soft-part sarcoma of the extremity: a case report. Hippokratia; 2008;12(4):251-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of the extremity: a case report.
  • Alveolar soft-part sarcoma (ASPS) is a rare form of soft tissue sarcoma and is most often seen in adolescents and young adults.
  • An 11- year-old boy with ASPS which presented with a markedly vascular tumor in the left thigh, and multiple bilateral pulmonary metastases 8 months after diagnosis is described.
  • The patient has remained disease-free for over 5 years since the initial diagnosis.

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  • [Cites] Cancer. 1989 Jan 1;63(1):1-13 [2642727.001]
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  • (PMID = 19158970.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2580048
  • [Keywords] NOTNLM ; alveolar soft – part sarcoma / children / long term survival / metastases / pulmonary
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88. Mizuno H, Hyakusoku H: Fat grafting to the breast and adipose-derived stem cells: recent scientific consensus and controversy. Aesthet Surg J; 2010 May-Jun;30(3):381-7
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  • However, new guidelines issued by the American Society of Plastic Surgeons in 2009 announced that fat grafting to the breast is not a strongly recommended procedure, as there are limited scientific data on the safety and efficacy of this particular type of fat transfer.
  • Recent progress by several groups has revealed that multipotent adult stem cells are present in human adipose tissue.
  • This cell population, termed adipose-derived stem cells (ADSC), represents a promising approach to future cell-based therapies, such as tissue engineering and regeneration.
  • Although tissue augmentation by fat grafting does have several advantages in that it is a noninvasive procedure and results in minimal scarring, it is essential that such a procedure be supported by evidence-based medicine and that further basic scientific and clinical research is conducted to ensure that fat grafting is a safe and effective procedure.

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  • [CommentIn] Aesthet Surg J. 2010 May-Jun;30(3):387-9 [20601561.001]
  • (PMID = 20601560.001).
  • [ISSN] 1527-330X
  • [Journal-full-title] Aesthetic surgery journal
  • [ISO-abbreviation] Aesthet Surg J
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 59
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89. Raney RB, Chintagumpala M, Anderson J, Pappo A, Qualman S, Wharam M, Wiener E, Meyer W, Soft-Tissue Sarcoma Committee of the Children's Oncology Group, Arcadia, California: Results of treatment of patients with superficial facial rhabdomyosarcomas on protocols of the Intergroup Rhabdomyosarcoma Study Group (IRSG), 1984-1997. Pediatr Blood Cancer; 2008 May;50(5):958-64
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  • RESULTS: Thirty-two patients were males; 35 patients were 1-9 years old at diagnosis.
  • Patients (46/47) had localized disease: 18 biopsy only (Group III), 17 microscopic residual tumor (Group II), and 11 complete resection without residual tumor (Group I).
  • Eight-year EFS rates were 72% for 22 patients with embryonal RMS and 53% for 23 patients with alveolar RMS (P = 0.28).

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18240175.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA072989; United States / NCI NIH HHS / CA / U10 CA029511; United States / NCI NIH HHS / CA / U10 CA072989-04; United States / NCI NIH HHS / CA / CA-24507; United States / NCI NIH HHS / CA / CA-72989; None / None / / U10 CA072989-04; United States / NCI NIH HHS / CA / U10 CA024507-26; None / None / / U10 CA024507-26; United States / NCI NIH HHS / CA / U10 CA029511-28; United States / NCI NIH HHS / CA / CA-29511; United States / NCI NIH HHS / CA / U10 CA024507
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS319313; NLM/ PMC3357210
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90. Benetos IS, Mavrogenis AF, Soultanis KCh, Zoubos AB, Papagelopoulos PJ, Soucacos PN: Alveolar soft part sarcoma of the forearm: a case report. J Surg Orthop Adv; 2006;15(4):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the forearm: a case report.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma that most commonly arises in the deep soft tissues of the lower extremities of adults.
  • Median survival of patients with metastatic ASPS has been reported to be from 3 to 3.3 years.
  • In this article, a case of an 11-year-old male with primary ASPS of the right forearm is presented.
  • Three years after diagnosis, the patient developed pulmonary metastases.
  • Chemotherapy was unsuccessfully used to control the metastatic disease.
  • This time to death after the development of metastases vastly exceeded the previously reported survival rates of patients with metastatic ASPS.
  • [MeSH-major] Forearm. Sarcoma, Alveolar Soft Part / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 17313933.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Haeck PC, Hait P: Into the twenty-first century: the history of the American Society of Plastic Surgeons from 1995 to 2006. Plast Reconstr Surg; 2006 Oct;118(5 Suppl):2S-31S
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  • [Title] Into the twenty-first century: the history of the American Society of Plastic Surgeons from 1995 to 2006.
  • [MeSH-major] Societies, Medical / history. Surgery, Plastic

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  • (PMID = 17006313.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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92. Wakely PE Jr, McDermott JE, Ali SZ: Cytopathology of alveolar soft part sarcoma: a report of 10 cases. Cancer; 2009 Dec 25;117(6):500-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytopathology of alveolar soft part sarcoma: a report of 10 cases.
  • BACKGROUND: Alveolar soft part sarcoma (ASPS) rarely is subjected to cytopathologic evaluation.
  • The objectives of the current study were to evaluate the cytomorphology of 10 ASPS cases on fine-needle aspiration (FNA) or imprint cytology, review the literature, and highlight potential diagnostic pitfalls.
  • METHODS: The authors searched their files for all lesions that were signed out as ASPS or suspicious for ASPS and searched the surgical pathology files for any cases of ASPS that had corresponding cytology.
  • RESULTS: Ten cases of ASPS were retrieved from 7 patients (male-to-female ratio, 4:3; mean age, 22 years).
  • All had subsequent tissue confirmation.
  • Nine cases were diagnosed correctly as ASPS/consistent with ASPS, and 1 specimen was diagnosed as "tumor, not otherwise specified".
  • CONCLUSIONS: The results of the current study indicated that ASPS has cytomorphology that overlaps with several other neoplasms, including renal cell carcinoma.
  • Nonetheless, the morphologic features, when combined with the clinical presentation, radiologic findings, and ancillary testing, may allow for a specific diagnosis.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Adult. Child. Diagnosis, Differential. Female. Humans. Male

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  • [Copyright] (c) 2009 American Cancer Society.
  • (PMID = 19787801.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Fox BD, Patel A, Suki D, Rao G: Surgical management of metastatic sarcoma to the brain. J Neurosurg; 2009 Jan;110(1):181-6
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  • [Title] Surgical management of metastatic sarcoma to the brain.
  • OBJECT: Metastatic sarcoma to the brain is rare and represents a therapeutic challenge due to its relative resistance to radio- and chemotherapy.
  • The authors reviewed a series of patients with metastatic sarcoma to the brain treated surgically to determine outcomes and identify predictors of survival in these patients.
  • METHODS: A retrospective review of prospectively collected data was undertaken on patients undergoing surgery between 1993 and 2005 for metastatic sarcoma to the brain at The University of Texas, M.D.
  • RESULTS: During the study period, 62 patients underwent 84 operations for metastatic sarcoma to the brain.
  • In multivariate and univariate analysis, control of systemic disease, and sarcomas originating from bone, cartilage, or soft tissue were predictors of survival.
  • Patients with control of systemic disease had survival advantage when compared with those who did not.
  • In patients with alveolar soft-part sarcoma, there was a significantly increased survival advantage compared with all other histological subgroups.
  • CONCLUSIONS: The authors' results suggest that in selected patients, resection of metastatic sarcoma to the brain is associated with a relatively low risk of operative death and results in improvement in neurological function.
  • Patients with systemic control of their primary disease and certain histological subtypes (specifically alveolar soft-part sarcoma) have improved overall and progression-free survival.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Neurosurgical Procedures. Sarcoma / secondary. Sarcoma / surgery


94. Nielsen LJ, Olsen LF, Ozalp VC: Aptamers embedded in polyacrylamide nanoparticles: a tool for in vivo metabolite sensing. ACS Nano; 2010 Aug 24;4(8):4361-70
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  • The AptaNPs comprise 30 nm polyacrylamide nanoparticles, prepared by inverse microemulsion polymerization, which contain water-soluble aptamer switch probes (ASPs) trapped in the porous matrix of the nanoparticles.

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  • (PMID = 20731422.001).
  • [ISSN] 1936-086X
  • [Journal-full-title] ACS nano
  • [ISO-abbreviation] ACS Nano
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / Adenine Nucleotides; 0 / Aptamers, Nucleotide; 0 / DNA Probes; 0 / Emulsions; 9003-05-8 / polyacrylamide
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95. Zarrin-Khameh N, Kaye KS: Alveolar soft part sarcoma. Arch Pathol Lab Med; 2007 Mar;131(3):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma.
  • This article provides an overview of the pathology of alveolar soft part sarcoma, focused on its morphology, special stains useful in diagnosis, and the clinical and radiographic features of the disease.
  • Alveolar soft part sarcoma is a rare neoplasm of unknown histogenesis with poor prognosis.
  • Although there are several immunohistochemical stains available to help reach the diagnosis, the morphology of the tumor should be considered the main diagnostic feature.
  • The periodic acid-Schiff stain is the best single stain that supports the diagnosis.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Prognosis

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  • (PMID = 17516754.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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96. Rohrich RJ, McGrath MH, Lawrence TW, ASPS Plastic Surgery Workforce Task Force, AAMC Center for Workforce Studies: Plastic surgeons over 50: practice patterns, satisfaction, and retirement plans. Plast Reconstr Surg; 2008 Apr;121(4):1458-74; discussion 1475-7
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  • [Title] Plastic surgeons over 50: practice patterns, satisfaction, and retirement plans.
  • BACKGROUND: Approximately 56 percent of all currently active plastic surgeons in the United States are older than 50 years and are likely to retire in the next 10 to 20 years.
  • The 2006 Survey of Plastic Surgeons Over the Age of 50 was designed to provide insight regarding the practice patterns, retirement plans, and issues of importance to plastic surgeons older than 50 to provide an indicator of future workforce needs for the specialty.
  • METHODS: The survey was part of a larger study of physicians older than 50 across all specialties conducted by the Association of American Medical Colleges Center for Workforce Studies, in collaboration with the American Society of Plastic Surgeons, the American Medical Association, the Council of Medical Specialty Societies, and seven additional medical specialty associations.
  • Surveys were mailed to 1434 active and retired plastic surgeons aged 50 to 79 years; the response rate was 59.1 percent.
  • RESULTS: Full-time reconstructive plastic surgeons older than 50 spend more hours per week practicing medicine (56.5 hours per week) than cosmetic plastic surgeons (49.7 hours per week) and all physicians (53.7 hours per week).
  • Plastic surgeons retire slightly earlier than other physicians and cite rising malpractice costs, insufficient reimbursement, and increasing competition as important factors when considering retirement.
  • CONCLUSIONS: There are significant differences in the practices, satisfaction, and factors influencing retirement plans for plastic surgeons that focus on cosmetic versus reconstructive surgery.
  • Further study of these two components of plastic surgery may be warranted.
  • [MeSH-major] Job Satisfaction. Practice Patterns, Physicians'. Retirement. Surgery, Plastic

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  • (PMID = 18349669.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Farkas V, Vass E, Hanssens I, Majer Z, Hollósi M: Cyclic peptide models of the Ca2+-binding loop of alpha-lactalbumin. Bioorg Med Chem; 2005 Sep 1;13(17):5310-20
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  • Infrared spectra showed that in the Ca2+ complex of model comprising the binding Asp residues of LA, the cation is coordinated to the COO- groups of all three Asps, while in the complex of model comprising nonbinding Asp residues of LA, the two neighboring Asp side chains form a bridged Ca2+-binding system.

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  • (PMID = 16046135.001).
  • [ISSN] 0968-0896
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Peptides, Cyclic; 9013-90-5 / Lactalbumin; SY7Q814VUP / Calcium
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98. Parham DM, Qualman SJ, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, Meyer WH, Soft Tissue Sarcoma Committee of the Children's Oncology Group: Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Am J Surg Pathol; 2007 Jun;31(6):895-901
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  • [Title] Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.
  • At the molecular level, alveolar rhabdomyosarcomas (ARMS) are characterized by 3 mutually exclusive PAX/FKHR conditions: PAX3/FKHR fusion (present in 60% of cases), PAX7/FKHR fusion (present in 20%), and PAX/FKHR fusion-negativity (present in 20%).
  • The possibility of morphologic variation among these molecular subtypes has not been investigated.
  • Of these features, only totally solid alveolar architecture reached significance (P=0.00014), with 7 of 16 PAX/FKHR-negative cases lacking this feature, compared with 0 of 36 PAX3/FKHR cases and 2/13 PAX7/FKHR cases.
  • These preliminary results indicate that in general, only totally solid alveolar architecture in ARMS may predict the absence of a PAX/FKHR fusion.
  • No features seemed to predict the presence of a particular fusion type.
  • [MeSH-major] Oncogene Proteins, Fusion / genetics. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Alveolar / pathology

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  • (PMID = 17527077.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 98543; United States / NCI NIH HHS / CA / CA24507; United States / NCI NIH HHS / CA / CA72989; United States / NCI NIH HHS / CA / CA81659; United States / NCI NIH HHS / CA / CA89461; United States / NCI NIH HHS / CA / CA98413; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FOXO1 protein, human; 0 / Forkhead Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / PAX3 protein, human; 0 / PAX7 Transcription Factor; 0 / PAX7 protein, human; 0 / Paired Box Transcription Factors
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99. Zibat A, Missiaglia E, Rosenberger A, Pritchard-Jones K, Shipley J, Hahn H, Fulda S: Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma. Oncogene; 2010 Dec 2;29(48):6323-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma.
  • Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and comprises two major histological subtypes: alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS).
  • [MeSH-major] Hedgehog Proteins / physiology. Rhabdomyosarcoma, Alveolar / metabolism. Rhabdomyosarcoma, Embryonal / metabolism. Signal Transduction / physiology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Gene Fusion. Humans. Infant. Kruppel-Like Transcription Factors / analysis. Male. Myogenic Regulatory Factor 5 / analysis. Nerve Tissue Proteins / analysis. Prognosis. Receptors, Cell Surface / analysis. Transcription Factors / analysis

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  • (PMID = 20818440.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / GLI3 protein, human; 0 / Hedgehog Proteins; 0 / Kruppel-Like Transcription Factors; 0 / MYF5 protein, human; 0 / Myogenic Regulatory Factor 5; 0 / Nerve Tissue Proteins; 0 / Receptors, Cell Surface; 0 / Transcription Factors; 0 / patched receptors
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100. Hersh AL, Beekmann SE, Polgreen PM, Zaoutis TE, Newland JG: Antimicrobial stewardship programs in pediatrics. Infect Control Hosp Epidemiol; 2009 Dec;30(12):1211-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To describe the prevalence, characteristics, and barriers to implementation of antimicrobial stewardship programs (ASPs) in pediatrics.
  • RESULTS: Of 246 pediatric infectious disease consultants surveyed, 147 (60%) responded.
  • The percentage of respondents from freestanding children's hospitals who were planning ASPs was higher than the percentage of respondents from other settings who were planning ASPs (P = .04).
  • Many programs were not monitoring important end points associated with ASPs, including cost and number of antibiotic-days.
  • CONCLUSIONS: The prevalence of ASPs in pediatrics is limited, and opportunities exist to improve current programs.

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  • (PMID = 19852666.001).
  • [ISSN] 1559-6834
  • [Journal-full-title] Infection control and hospital epidemiology
  • [ISO-abbreviation] Infect Control Hosp Epidemiol
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / T32HD044331; United States / NCPDCID CDC HHS / CI / U50 CI000358
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents
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