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1. Riggs NR, Bohnert AM, Guzman MD, Davidson D: Examining the potential of community-based after-school programs for Latino youth. Am J Community Psychol; 2010 Jun;45(3-4):417-29
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  • Results are presented from two pilot studies examining the potential influence of community-based after-school programs (ASPs) on regionally diverse Latino youth of varying ages.
  • Findings illustrate how ASPs with varying strategies, activities, and assessment tools can be evaluated in the interest of designing future large-scale investigations into ASPs and Latino positive youth development.

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  • (PMID = 20300821.001).
  • [ISSN] 1573-2770
  • [Journal-full-title] American journal of community psychology
  • [ISO-abbreviation] Am J Community Psychol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Streu R, Hawley S, Gay A, Salem B, Abrahamse P, Alderman AK: Satisfaction with career choice among U.S. plastic surgeons: results from a national survey. Plast Reconstr Surg; 2010 Aug;126(2):636-42
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  • [Title] Satisfaction with career choice among U.S. plastic surgeons: results from a national survey.
  • BACKGROUND: The authors' purpose was to describe patterns and correlates of satisfaction with career choice among U.S. plastic surgeons.
  • METHODS: A mailed, self-administered survey was sent to 708 U.S. plastic surgeons who were randomly sampled from the American Society of Plastic Surgeons registry (71 percent response rate, n = 505).
  • The dependent variable was satisfaction with the decision to become a plastic surgeon, which was created from a scale of four validated questions measuring decisional satisfaction and decisional regret.
  • Logistic regression was used to evaluate associations between satisfaction with the decision to become a plastic surgeon and independent factors.
  • RESULTS: Few respondents (4 percent) regretted becoming plastic surgeons.
  • Factors independently associated with greater satisfaction with the decision to become a plastic surgeon included group practice compared with solo practice (odds ratio, 1.65; 95 percent confidence interval, 1.0 to 2.71), resident educator (odds ratio, 1.88; 95 percent confidence interval, 1.06 to 3.31), and a highly cosmetic practice mix: primarily cosmetic versus primarily reconstructive (odds ratio, 2.42; 95 percent confidence interval, 1.25 to 4.66) and mixed versus primarily reconstructive (odds ratio, 1.59, 95 percent confidence interval, 0.92 to 2.76).
  • CONCLUSIONS: Overall, the majority of plastic surgeons are satisfied with their career choice despite the current health care and economic environment.
  • [MeSH-major] Career Choice. Job Satisfaction. Surgery, Plastic / manpower. Surveys and Questionnaires

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  • (PMID = 20375767.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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3. Vistica DT, Krosky PM, Kenney S, Raffeld M, Shoemaker RH: Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma. J Pediatr Hematol Oncol; 2008 Jan;30(1):46-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS), a rare soft tissue sarcoma, is characterized by a chromosomal translocation der(17)t(X;17)(p11;q25) resulting in the production of 2 fusion proteins encoded by regions of the genes for alveolar soft part locus (ASPL) and the transcription factor E3 (TFE3).
  • Immunohistochemical staining of formalin-fixed, paraffin-embedded ASPS tumors with the fusion-specific antibodies resulted in intense nuclear staining and differentiation between tumors that express the type 1 protein and tumors that express the type 2 protein.
  • These antibodies will be useful for the differential diagnosis of type 1 and type 2 ASPS and also in the detection of the fusion proteins in biochemical and cell biologic investigations.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism. Cell Nucleus / metabolism. Neoplasm Proteins / metabolism. Oncogene Proteins, Fusion / metabolism. Rare Diseases / metabolism. Sarcoma / metabolism
  • [MeSH-minor] Adolescent. Antibodies / chemistry. Antibodies / immunology. Child. Child, Preschool. Diagnosis, Differential. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunohistochemistry. Male. Recombinant Proteins / chemistry. Recombinant Proteins / genetics. Recombinant Proteins / immunology. Translocation, Genetic / immunology

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  • (PMID = 18176180.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Antibodies; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / Recombinant Proteins; 0 / TFE3 protein, human
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4. Piotrowski A, Stengert W, Stolarska M, Fendler W: [Acute respiratory failure in a 16-yr-old girl with alveolar soft part sarcoma]. Anestezjol Intens Ter; 2008 Jan-Mar;40(1):28-31
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  • [Title] [Acute respiratory failure in a 16-yr-old girl with alveolar soft part sarcoma].
  • [Transliterated title] Problemy diagnostyczne i terapeutyczne ostrej niewydolności oddechowej u 16-letniej dziewczynki z miesakiem tkanek miqkkich.
  • We present a patient with severe pneumonia and pleural effusion, that developed during treatment of a soft tissue sarcoma with pulmonary metastases.
  • [MeSH-major] Aspergillosis / complications. Aspergillosis / diagnosis. Lung Diseases, Fungal / complications. Lung Diseases, Fungal / diagnosis. Respiratory Insufficiency / etiology. Sarcoma / complications
  • [MeSH-minor] Adolescent. Bronchoalveolar Lavage Fluid / microbiology. Diagnosis, Differential. Drainage. Female. Humans. Immunocompromised Host. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Pleural Effusion / etiology. Pneumonia / etiology


5. Fadare O: Uncommon sarcomas of the uterine cervix: a review of selected entities. Diagn Pathol; 2006;1:30
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  • [Title] Uncommon sarcomas of the uterine cervix: a review of selected entities.
  • Sarcomas constitute less than 1% of all cervical malignancies.
  • With over 150 reported cases, rhabdomyosarcomas represent the most commonly reported sarcoma at this location.
  • In this report, a select group of the more uncommon sarcomas of the uterine cervix are reviewed, including all previously reported examples of leiomyosarcoma, liposarcoma, alveolar soft part sarcoma, Ewing sarcoma/primitive neuroectodermal tumor, undifferentiated endocervical sarcoma, and malignant peripheral nerve sheath tumor (MPNST).

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  • (PMID = 16981999.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
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6. Balgley BM, Guo T, Zhao K, Fang X, Tavassoli FA, Lee CS: Evaluation of archival time on shotgun proteomics of formalin-fixed and paraffin-embedded tissues. J Proteome Res; 2009 Feb;8(2):917-25
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  • There is increasing acceptance of the critical importance of correlating the morphologic features of tissue with the data obtained from various molecular analytic techniques.
  • Access to archived formalin-fixed and paraffin-embedded (FFPE) tissue specimens via shotgun-based proteomic analyses may, therefore, open new avenues for both prospective and retrospective translational research.
  • Optimized protein extraction and digestion procedures for handling FFPE tissues are coupled with the capillary isotachophoresis-based proteome technology to evaluate the effects of length of storage period on archival tissue proteome analysis across 10 archived uterine mesenchymal tumor tissue blocks, including 9 uterine leiomyomas dating from 1990 to 2002 and a single case of alveolar soft part sarcoma (ASPS) from 1980.
  • Low abundance proteins may be more susceptible to the long-term storage as these proteins are more difficult to be retrieved and extracted as the tissue block ages in paraffin.
  • Despite using tissue blocks stored for as many as 28 years, high confidence and comparative proteome analysis between the leiomyomas and the sarcoma is achieved.
  • Though sharing over 1800 common proteins in a core set, a total of 80 proteins unique to the sarcoma are identified distinguishing the ASPS from the leiomyomas.
  • Vacuolar proton translocating ATPase 116 kDa subunit isoform a3, one of the unique proteins expressed in the ASPS, is further validated by immunohistochemistry (IHC).

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  • (PMID = 19128014.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM073723; United States / NCI NIH HHS / CA / R42 CA122715; United States / NIGMS NIH HHS / GM / R01 GM073723-04; United States / NCI NIH HHS / CA / R41 CA122715; United States / NCI NIH HHS / CA / CA122715; United States / NIGMS NIH HHS / GM / GM073723; United States / NIGMS NIH HHS / GM / GM073723-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptides; 1HG84L3525 / Formaldehyde
  • [Other-IDs] NLM/ NIHMS91394; NLM/ PMC2664629
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7. Taulli R, Bersani F, Foglizzo V, Linari A, Vigna E, Ladanyi M, Tuschl T, Ponzetto C: The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J Clin Invest; 2009 Aug;119(8):2366-78
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  • In this work, we examined the role of the muscle-specific miRNAs miR-1 and miR-206 in human rhabdomyosarcoma (RMS), a soft tissue sarcoma thought to arise from skeletal muscle progenitors.
  • We have shown that miR-1 was barely detectable in primary RMS of both the embryonal and alveolar subtypes and that both miR-1 and miR-206 failed to be induced in RMS cell lines upon serum deprivation.
  • We propose that tissue-specific miRNAs such as miR-1 and miR-206, given their ability to modulate hundreds of transcripts and to act as nontoxic differentiating agents, may override the genomic heterogeneity of solid tumors and ultimately hold greater therapeutic potential than single gene-directed drugs.


8. Raghunandhan S, Murali S, Nagasundaram J, Sudha Maheswari S, Kameswaran M: Alveolar soft part sarcoma of tongue base - A rare presentation of a rare tumor. Indian J Otolaryngol Head Neck Surg; 2007 Dec;59(4):393-5
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  • [Title] Alveolar soft part sarcoma of tongue base - A rare presentation of a rare tumor.
  • Alveolar soft part sarcoma is a rare, aggressive malignancy of uncertain histologic origin and enigmatic clinical behaviour.
  • We report a case of alveolar soft part sarcoma involving the tongue base in an adolescent female.

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  • [Cites] Skeletal Radiol. 1995 May;24(4):267-70 [7644939.001]
  • (PMID = 23120485.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452256
  • [Keywords] NOTNLM ; Immunohistochemistry / Lingual Alveolar Soft Part Sarcoma (ASPS)
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9. Carter JE, Evans TN, Tucker JA: Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report. Acta Cytol; 2008 Jul-Aug;52(4):459-63
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  • [Title] Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report.
  • BACKGROUND: Alveolar soft part sarcoma is a rare soft tissue tumor of uncertain origin that is generally slow growing but unmistakably malignant due to its propensity for metastasis to lung, bone and brain early in the course of disease.
  • CASE: A 54-year-old African-American man presented to our institution with a 2-week history of left leg pain.
  • Imaging studies revealed a left leg soft tissue mass just below the popliteal fossa and multiple bilateral lung lesions suggestive of metastatic neoplasm.
  • A periodic acid-Schiff (PAS) stain highlighted intracytoplasmic rhomboidal crystals, a feature diagnostic of alveolar soft part sarcoma.
  • CONCLUSION: Alveolar soft part sarcoma may be diagnosed by its unique morphologic characteristics and should be considered in the differential diagnosis of all cytologically sampled soft tissue lesions.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biopsy. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Leg. Male. Microscopy, Electron. Middle Aged. Periodic Acid-Schiff Reaction. Tomography, X-Ray Computed

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  • (PMID = 18702365.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Rohrich RJ, Parker TH 3rd, Broughton G 2nd, Garza R, Leblanc D: The importance of advanced cardiac life support certification in office-based surgery. Plast Reconstr Surg; 2008 Mar;121(3):93e-101e
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A survey was recently designed and distributed to assess the experience and attitudes of board-certified plastic surgeons toward Advanced Cardiac Life Support training.
  • METHODS: A two-page, 14-question survey was mailed to the 4581 members of the American Society of Plastic Surgeons.
  • Over the past 10 years, 29 percent of plastic surgeons participated in a cardiac or respiratory arrest, and 43.9 percent of these surgeons acted as the code leader; 60.2 percent of plastic surgeons felt Advanced Cardiac Life Support certification should be required, but only 26 percent of these felt it should be mandated to maintain board certification.
  • The American Society of Plastic Surgeons and the American Society for Aesthetic Plastic Surgery have taken steps to increase patient safety, mandating that outpatient plastic surgery only be performed at accredited facilities.
  • [MeSH-major] Advanced Cardiac Life Support / education. Advanced Cardiac Life Support / standards. Ambulatory Surgical Procedures / standards. Certification / standards. Surgery, Plastic / standards

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  • (PMID = 18317091.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Cribbs RK, Shehata BM, Ricketts RR: Primary ovarian rhabdomyosarcoma in children. Pediatr Surg Int; 2008 May;24(5):593-5
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  • Although rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, primary rhabdomyosarcomas of the ovary are extremely rare, with only eight well-documented pediatric cases previously reported in the literature.
  • We present two additional cases: an alveolar RMS originating in the right ovary with metastatic spread to the splenic flexure of the colon and to both lungs in a 13-year-old African American girl, and an embryonal RMS arising in the right ovary of a 6-year-old Caucasian girl with pre-operative intra-abdominal rupture and a malignant right pleural effusion.
  • [MeSH-major] Ovarian Neoplasms / diagnosis. Rhabdomyosarcoma / diagnosis
  • [MeSH-minor] Adolescent. Biopsy, Needle. Chemotherapy, Adjuvant. Child. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Laparoscopy. Ovariectomy / methods. Tomography, X-Ray Computed

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  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
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12. Khan R, Takahashi E, Ramamurthy T, Takeda Y, Okamoto K: Salt in surroundings influences the production of serine protease into milieu by Aeromonas sobria. Microbiol Immunol; 2007;51(10):963-76
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  • However, these ASPs in milieu formed complex as with ORF2 proteins.

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  • (PMID = 17951986.001).
  • [ISSN] 0385-5600
  • [Journal-full-title] Microbiology and immunology
  • [ISO-abbreviation] Microbiol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Culture Media; 0 / Culture Media, Conditioned; 0 / Molecular Chaperones; 451W47IQ8X / Sodium Chloride; EC 3.4.21.- / Serine Endopeptidases
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13. Gurunluoglu R: Panniculectomy and redundant skin surgery in massive weight loss patients: current guidelines and recommendations for medical necessity determination. Ann Plast Surg; 2008 Dec;61(6):654-7
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  • There is certain insurance coverage criteria for panniculectomy and redundant skin surgery that every plastic surgeon participating in the surgical treatment of massive weight loss patients should be familiar with to accurately document and present the clinical findings of their patients.
  • In addition, insurance coverage criteria for redundant skin surgery and panniculectomy recommended by American Society of Plastic Surgeons (ASPS) for third-party payers were reviewed.
  • Although the criteria used by third-party payers are conceptually similar to those recommended by ASPS, in practice they are harder to meet by most weight loss patients.
  • This discrepancy leads to a group of denied patients who would otherwise be authorized for plastic surgery after massive weight loss, when actual ASPS recommendations are taken into consideration.
  • This review article points out to the fact that there is a need for development of new set of guidelines for those sites and for modification of current guidelines for medical necessity determination of panniculectomy used among third-party payers, according to actual ASPS recommendations.

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  • (PMID = 19034082.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Folpe AL, Deyrup AT: Alveolar soft-part sarcoma: a review and update. J Clin Pathol; 2006 Nov;59(11):1127-32
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  • [Title] Alveolar soft-part sarcoma: a review and update.
  • Alveolar soft-part sarcoma (ASPS) is a rare, distinctive sarcoma, typically occurring in young patients.
  • Recently, our understanding of the genetic events underlying the pathogenesis of ASPS has greatly increased.
  • The historical, histopathological, ultrastructural, immunohistochemical and genetic aspects of ASPS are reviewed in this article.
  • [MeSH-major] Sarcoma, Alveolar Soft Part
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Translocation, Genetic

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  • (PMID = 17071801.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 63
  • [Other-IDs] NLM/ PMC1860509
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15. Aisner SC, Beebe K, Blacksin M, Mirani N, Hameed M: Primary alveolar soft part sarcoma of fibula demonstrating ASPL-TFE3 fusion: a case report and review of the literature. Skeletal Radiol; 2008 Nov;37(11):1047-51
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  • [Title] Primary alveolar soft part sarcoma of fibula demonstrating ASPL-TFE3 fusion: a case report and review of the literature.
  • Alveolar soft part sarcoma is a rare soft tissue tumor typically affecting young adults.
  • These tumors are most often seen in the deep soft tissues of the extremities and patients generally present with advanced disease.
  • This is the first case of alveolar soft part sarcoma in bone documenting the ASPL-TFE3 gene product.
  • Herein, we report a rare presentation of alveolar soft part sarcoma presenting as a primary bone neoplasm involving the proximal fibula in a 41-year-old woman.
  • [MeSH-major] Fibula / pathology. Sarcoma, Alveolar Soft Part / diagnosis
  • [MeSH-minor] Adult. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Oncogene Proteins, Fusion. Tomography, X-Ray Computed

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  • (PMID = 18594808.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
  • [Number-of-references] 23
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16. Souid AK, Dubowy RL, Ingle AM, Conlan MG, Sun J, Blaney SM, Adamson PC: A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study. Pediatr Blood Cancer; 2010 Dec 15;55(7):1323-8
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  • There were no objective responses, but three patients (diagnoses of anaplastic astrocytoma, alveolar soft part sarcoma, and ependymoblastoma) had stable disease for 4-7 courses.

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
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  • (PMID = 20712019.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA097452-10; United States / NCI NIH HHS / CA / U01 CA097452; United States / NCI NIH HHS / CA / U01 CA097452-10; United States / NCI NIH HHS / CA / U01 CA97452
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzamides; 0 / KIF11 protein, human; 0 / Quinazolines; BKT5F9C2NI / ispinesib; EC 3.6.1.- / Kinesin
  • [Other-IDs] NLM/ NIHMS263509; NLM/ PMC3053384
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17. Carpen JD, Archer SN, Skene DJ, Smits M, von Schantz M: A single-nucleotide polymorphism in the 5'-untranslated region of the hPER2 gene is associated with diurnal preference. J Sleep Res; 2005 Sep;14(3):293-7
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  • A missense mutation in the human PER2 gene has previously been linked to advanced sleep phase syndrome (ASPS).
  • The PER2 111G allele associates with morning preference and is a potential candidate allele for ASPS.

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  • (PMID = 16120104.001).
  • [ISSN] 0962-1105
  • [Journal-full-title] Journal of sleep research
  • [ISO-abbreviation] J Sleep Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 5' Untranslated Regions; 0 / Codon, Initiator; 0 / DNA Primers; 0 / Nuclear Proteins; 0 / Nucleocytoplasmic Transport Proteins; 0 / PER2 protein, human; 0 / Period Circadian Proteins; 0 / Transcription Factors
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18. Butler AW, Breen G, Tozzi F, Craddock N, Gill M, Korszun A, Maier W, Middleton LT, Mors O, Owen MJ, Perry J, Preisig M, Rice JP, Rietschel M, Jones L, Farmer AE, Lewis CM, McGuffin P: A genomewide linkage study on suicidality in major depressive disorder confirms evidence for linkage to 2p12. Am J Med Genet B Neuropsychiatr Genet; 2010 Dec 05;153B(8):1465-73
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  • [Title] A genomewide linkage study on suicidality in major depressive disorder confirms evidence for linkage to 2p12.
  • Twin studies indicate that both suicidality and major depressive disorder (MDD) are heritable.
  • However, epidemiological evidence suggests that the inheritance of suicidality is likely to be independent of the underlying psychiatric disorder, implying a distinct genetic contribution to suicidality.
  • Affected sibling pair (ASP) variance components analysis was performed using the Depression Network cohort of 971 ASPs.
  • [MeSH-major] Chromosomes, Human, Pair 2 / genetics. Depressive Disorder, Major / genetics. Genetic Linkage. Suicidal Ideation. Suicide, Attempted
  • [MeSH-minor] Adult. Age of Onset. Chromosome Mapping. Female. Genetic Markers / genetics. Genetic Predisposition to Disease. Genome-Wide Association Study. Genotype. Humans. Lod Score. Male. Microsatellite Repeats. Middle Aged. Phenotype. Risk Factors. Siblings

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • [CommentIn] Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):864-5 author reply 866-7 [22003500.001]
  • (PMID = 20886545.001).
  • [ISSN] 1552-485X
  • [Journal-full-title] American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • [ISO-abbreviation] Am. J. Med. Genet. B Neuropsychiatr. Genet.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0701003; United Kingdom / Medical Research Council / / G0701420; United Kingdom / Medical Research Council / / G90/106
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
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19. Kanhere HA, Pai PS, Neeli SI, Kantharia R, Saoji RR, D'cruz AK: Alveolar soft part sarcoma of the head and neck. Int J Oral Maxillofac Surg; 2005 May;34(3):268-72
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  • [Title] Alveolar soft part sarcoma of the head and neck.
  • Alveolar soft part sarcoma (ASPS) of the head and neck region has been a rarely reported entity.
  • A retrospective study of the medical records at our institute, revealed thirty-eight cases of ASPS.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / therapy
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Disease-Free Survival. Female. Humans. Male. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 15741035.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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20. Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Ohara K, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y, Japanese Schizophrenia Sib-Pair Linkage Group: Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p. Am J Hum Genet; 2005 Dec;77(6):937-44
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  • We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia.
  • All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia.
  • Although linkage to these regions has received little attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis.
  • Results of the present study--which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent--indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.
  • [MeSH-minor] Genetic Markers. Genetic Predisposition to Disease. Genome, Human. Humans. Japan / epidemiology. Lod Score. Microsatellite Repeats. Pedigree. Siblings

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  • (PMID = 16380906.001).
  • [ISSN] 0002-9297
  • [Journal-full-title] American journal of human genetics
  • [ISO-abbreviation] Am. J. Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC1285184
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21. Davicioni E, Anderson MJ, Finckenstein FG, Lynch JC, Qualman SJ, Shimada H, Schofield DE, Buckley JD, Meyer WH, Sorensen PH, Triche TJ: Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group. Am J Pathol; 2009 Feb;174(2):550-64
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  • [Title] Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group.
  • Rhabdomyosarcoma (RMS) in children occurs as two major histological subtypes, embryonal (ERMS) and alveolar (ARMS).
  • ERMS is associated with an 11p15.5 loss of heterozygosity (LOH) and may be confused with nonmyogenic, non-RMS soft tissue sarcomas.
  • ARMS expresses the product of a genomic translocation that fuses FOXO1 (FKHR) with either PAX3 or PAX7 (P-F); however, at least 25% of cases lack these translocations.
  • Here, we describe a genomic-based classification scheme that is derived from the combined gene expression profiling and LOH analysis of 160 cases of RMS and non-RMS soft tissue sarcomas that is at variance with conventional histopathological schemes.
  • These objectively derived molecular classes are based solely on genomic analysis at the time of diagnosis and are highly reproducible.

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  • (PMID = 19147825.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA088199; United States / NCI NIH HHS / CA / U01 CA114757; United States / NCI NIH HHS / CA / CA-88199; United States / NCI NIH HHS / CA / U01CA-114757
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / HMGA2 Protein; 0 / TFAP2B protein, human; 0 / Transcription Factor AP-2
  • [Other-IDs] NLM/ PMC2630563
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22. Morgenstern DA, Anderson J: MYCN deregulation as a potential target for novel therapies in rhabdomyosarcoma. Expert Rev Anticancer Ther; 2006 Feb;6(2):217-24
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  • Rhabdomyosarcoma is the most common soft-tissue sarcoma of childhood.
  • Although overall outcomes have improved considerably, the outlook for patients with high-risk disease, particularly the alveolar subtype, remains bleak and there is a clear need for new chemotherapeutic strategies.
  • The importance of aberrant expression of this oncogene is well established in neuroblastoma and recent data indicate that MYCN deregulation also occurs in up to a quarter of alveolar subtype cases.

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  • (PMID = 16445374.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / MYCN protein, human; 0 / Nuclear Proteins; 0 / Nucleic Acids; 0 / Oligonucleotides, Antisense; 0 / Oncogene Proteins
  • [Number-of-references] 74
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23. Mentz HA, Ruiz-Razura A, Newall G, Patronella CK, Miniel LA: Correction of gynecomastia through a single puncture incision. Aesthetic Plast Surg; 2007 May-Jun;31(3):244-9
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  • In 2004, board-certified plastic surgeons performed 16,275 corrective procedures, and in 2005 there was a 17% increase, according to The American Society of Plastic Surgeons (ASPS) procedural statistics.
  • This report describes a surgical approach for removal of both glandular and adipose tissue using a small 3-mm areolar stab wound incision and a piecemeal glandular resection to correct gynecomastia with minimal and imperceptible external scarring.

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  • (PMID = 17380361.001).
  • [ISSN] 0364-216X
  • [Journal-full-title] Aesthetic plastic surgery
  • [ISO-abbreviation] Aesthetic Plast Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Costa AF, Gasser RB, Dias SR, Rabelo EM: Male-enriched transcription of genes encoding ASPs and Kunitz-type protease inhibitors in Ancylostoma species. Mol Cell Probes; 2009 Dec;23(6):298-303
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  • [Title] Male-enriched transcription of genes encoding ASPs and Kunitz-type protease inhibitors in Ancylostoma species.
  • Specifically, partial cDNA sequences encoding three different ASP molecules and two different Kunitz-type protease inhibitors were isolated, and the differential transcription between adult male and female worms was compared by conventional and quantitative reverse transcription (RT)-PCR for three species, A. braziliense, Ancylostoma caninum and Ancylostoma ceylanicum.

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  • (PMID = 19646525.001).
  • [ISSN] 1096-1194
  • [Journal-full-title] Molecular and cellular probes
  • [ISO-abbreviation] Mol. Cell. Probes
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ FJ593957/ FJ593958/ FJ593959/ FJ593960
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Complementary; 0 / Helminth Proteins; 0 / Serine Proteinase Inhibitors
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25. Mercado GE, Barr FG: Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances. Curr Mol Med; 2007 Feb;7(1):47-61
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  • [Title] Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances.
  • Rhabdomyosarcoma is the most frequent soft tissue sarcoma in the pediatric population.
  • Two main histopathologic variants have been described, embryonal (ERMS) and alveolar (ARMS), which demonstrate clinical and genetic differences.
  • This review highlights recent advances in numerous areas of biomedical investigation that are providing new insights into the biology, molecular pathology, and translational science of ARMS: the identification of downstream targets of PAX3-FKHR and collaborating events in the process of tumorigenesis and metastasis; generation of animal models based on the gene fusion and collaborating events; development of new assays for diagnosis, prognosis, and detection of minimal disseminated disease; and exploration of immune recognition of this tumor and the fusion protein.
  • [MeSH-major] Oncogene Proteins, Fusion / genetics. Paired Box Transcription Factors / genetics. Rhabdomyosarcoma, Alveolar / pathology
  • [MeSH-minor] Animals. Chromosomes, Human, Pair 13 / genetics. Chromosomes, Human, Pair 2 / genetics. Disease Models, Animal. Humans. Translocation, Genetic

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  • (PMID = 17311532.001).
  • [ISSN] 1566-5240
  • [Journal-full-title] Current molecular medicine
  • [ISO-abbreviation] Curr. Mol. Med.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA64202; United States / NCI NIH HHS / CA / CA87812; United States / NCI NIH HHS / CA / CA89461
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / PAX3-FOXO1A fusion protein, human; 0 / Paired Box Transcription Factors
  • [Number-of-references] 101
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26. Yamaguchi T, Kuroda N, Imamura Y, Hes O, Kawada T, Nakayama K: Imprint cytologic features in renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in an adult: a case report. Acta Cytol; 2009 Nov-Dec;53(6):693-7
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  • Ultrastructurally, neoplastic cells contained rhomboid crystals identical to those of alveolar soft part sarcoma.
  • CONCLUSION: The immunocytochemistry of TFE3 protein may be a powerful tool for accurate diagnosis when RCC associated with Xp11.2 translocation/TFE3 gene fusion is suspected by imprint cytology even in adult-onset cases, and cytotechnologists should accurately recognize cytologic findings of this tumor.

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  • (PMID = 20014561.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / TFE3 protein, human
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27. Dezanzo P, Lifschitz-Mercer B, Czernobilsky B, Rosai J: Alveolar soft-part sarcoma of paranasal sinuses. Int J Surg Pathol; 2010 Feb;18(1):66-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of paranasal sinuses.
  • [MeSH-major] Paranasal Sinus Neoplasms / pathology. Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Paraganglioma / diagnosis. Periodic Acid-Schiff Reaction. Perivascular Epithelioid Cell Neoplasms / diagnosis. Young Adult

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  • (PMID = 19926641.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / TFE3 protein, human
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28. Thomas DM, O'Sullivan B, Gronchi A: Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management. Expert Rev Anticancer Ther; 2009 Aug;9(8):1145-57
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  • [Title] Current concepts and future perspectives in retroperitoneal soft-tissue sarcoma management.
  • Retroperitoneal soft-tissue sarcomas are complex, heterogeneous cancers requiring expert multidisciplinary care.
  • The most common adult subtypes are liposarcomas and leiomyosarcomas, followed by pleomorphic sarcoma/malignant fibros histiocytoma (an entity not always easily distinguishable from dedifferentiated liposarcoma).
  • Pediatric subtypes mainly comprise extraskeletal Ewing sarcoma/pPNET and alveolar rhabdomyosarcoma.
  • It may also provide useful palliation for patients with advanced slow-growing disease.
  • Chemotherapy has a limited role in the adjuvant setting for most forms of retroperitoneal sarcoma (excluding pediatric subtypes), but has an increasing role in advanced disease.
  • [MeSH-major] Retroperitoneal Neoplasms / therapy. Sarcoma / therapy

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  • (PMID = 19671034.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 93
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29. Boylston MT, Jackson C: Adult student satisfaction in an accelerated RN-to-BSN program: a follow-up study. J Prof Nurs; 2008 Sep-Oct;24(5):285-95
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  • [Title] Adult student satisfaction in an accelerated RN-to-BSN program: a follow-up study.
  • This mixed-method study revealed accelerated RN-to-BSN (bachelor of science in nursing) students' levels of satisfaction with a wide range of college services in a small university.
  • Adult student satisfaction in traditional and accelerated RN-to-BSN programs.
  • ], the Noel-Levitz Adult Student Priorities Survey (ASPS) and qualitative interview data revealed primary factors involved in nontraditional (adult) accelerated RN-to-BSN student satisfaction.
  • The ASPS assesses both satisfaction with and importance of the following factors: academic advising effectiveness, academic services, admissions and financial aid effectiveness, campus climate, instructional effectiveness, registration effectiveness, safety and security, and service excellence.

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  • (PMID = 18804082.001).
  • [ISSN] 1532-8481
  • [Journal-full-title] Journal of professional nursing : official journal of the American Association of Colleges of Nursing
  • [ISO-abbreviation] J Prof Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Sperry S, Thompson JK, Sarwer DB, Cash TF: Cosmetic surgery reality TV viewership: relations with cosmetic surgery attitudes, body image, and disordered eating. Ann Plast Surg; 2009 Jan;62(1):7-11
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  • BACKGROUND: According to the American Society of Plastic Surgeons (2007), the number of cosmetic procedures has increased to over 10 million in 2006, representing a 48% increase from 2000.
  • RESULTS: Viewership of reality cosmetic surgery shows was significantly related to more favorable cosmetic surgery attitudes, perceived pressure to have cosmetic surgery, past attainment of a cosmetic procedure, a decreased fear of surgery, as well as overall body dissatisfaction, media internalization, and disordered eating.
  • Additionally, the findings indicate that surgeons may want to assess the relevance of cosmetic surgery reality TV viewership for patients' attitudes towards and expectations about cosmetic surgery.


31. Antillon F, Castellanos M, Valverde P, Luna-Fineman S, Garrido C, Serrato T, Rodriguez-Galindo C, Casanova M, Ferrari A: Treating Pediatric soft tissue sarcomas in a country with limited resources: the experience of the Unidad Nacional de Oncologia Pediatrica in Guatemala. Pediatr Blood Cancer; 2008 Dec;51(6):760-4
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  • [Title] Treating Pediatric soft tissue sarcomas in a country with limited resources: the experience of the Unidad Nacional de Oncologia Pediatrica in Guatemala.
  • BACKGROUND: About 250-300 children with newly diagnosed cancer are treated each year at the Unidad Nacional de Oncologia Pediatrica in Guatemala City; less than 5% of them have soft tissue sarcomas (STS).
  • PATIENTS AND METHODS: We reviewed the clinical data, treatment and outcome of 80 patients, 47 cases of rhabdomyosarcoma (RMS) and 33 of non-rhabdomyosarcoma soft tissue sarcoma (NRSTS), treated between January 2000 and October 2007.
  • RESULTS: Most of the RMS patients had advanced disease at diagnosis (87% groups III-IV).
  • Outcome was satisfactory for synovial sarcoma patients, those with tumors < or =5 cm, and those with localized disease.
  • Late diagnosis and the consequently high proportion of cases of advanced disease at diagnosis, the large number of patients failing to complete the treatment, and the poor quality of local control (in RMS) adversely influence outcome.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Developing Countries. Rhabdomyosarcoma, Alveolar / drug therapy. Rhabdomyosarcoma, Embryonal / drug therapy. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 18680154.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Beets MW, Rooney L, Tilley F, Beighle A, Webster C: Evaluation of policies to promote physical activity in afterschool programs: are we meeting current benchmarks? Prev Med; 2010 Sep-Oct;51(3-4):299-301
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  • We examined the extent to which children attending ASPs meet existing national and state-level policies that specify expected levels of physical activity (PA).
  • CONCLUSIONS: The PA of children attending ASP falls below policy recommended levels; however, these policies were developed in absence of data on expected PA levels during ASPs.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20637796.001).
  • [ISSN] 1096-0260
  • [Journal-full-title] Preventive medicine
  • [ISO-abbreviation] Prev Med
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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33. Thomas P, Mathur P, Gottesman II, Nagpal R, Nimgaonkar VL, Deshpande SN: Correlates of hallucinations in schizophrenia: A cross-cultural evaluation. Schizophr Res; 2007 May;92(1-3):41-9
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  • METHODS: Patients with a clinical diagnosis of schizophrenia (SZ) or schizoaffective disorder (SZA) were diagnosed systematically using DSM IV criteria.
  • To evaluate the impact of familial factors, we separately analyzed correlations among affected sibling pairs (ASPs, n=136, Indian; n=77, US).
  • No significant concordance was observed among the ASPs after correcting for multiple comparisons.
  • [MeSH-minor] Adult. Cross-Cultural Comparison. Demography. Diagnostic and Statistical Manual of Mental Disorders. Environment. Factor Analysis, Statistical. Female. Humans. India / epidemiology. Male. Phenotype. Prevalence. Psychotic Disorders / diagnosis. Psychotic Disorders / ethnology. Psychotic Disorders / genetics. United States / epidemiology

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  • [Cites] Soc Psychiatry Psychiatr Epidemiol. 2004 May;39(5):369-74 [15133593.001]
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  • (PMID = 17350224.001).
  • [ISSN] 0920-9964
  • [Journal-full-title] Schizophrenia research
  • [ISO-abbreviation] Schizophr. Res.
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / MH53459; United States / NIMH NIH HHS / MH / R10 MH056242; United States / NIMH NIH HHS / MH / MH56242; United States / NIMH NIH HHS / MH / R01 MH056242; United States / NIMH NIH HHS / MH / MH01489
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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34. Halperin TJ, Werler MM, Mulliken JB: Gender differences in the professional and private lives of plastic surgeons. Ann Plast Surg; 2010 Jun;64(6):775-9
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  • [Title] Gender differences in the professional and private lives of plastic surgeons.
  • There are over 700 female members in the American Society of Plastic Surgeons.
  • The purpose of this study was to assess possible differences between female and male plastic surgeons with respect to their practice characteristics, duration of practice, and some aspects of their private lives.
  • We designed a 41 question survey to compare the practice features and personal demographics of female and male members of the American Society of Plastic Surgeons.
  • Male plastic surgeons were more than twice as likely as female plastic surgeons to earn an income greater than $400,000 per year (P < 0.001).
  • Female plastic surgeons are significantly more likely to be unmarried, to postpone having children or be childless, as compared to their male counterparts.
  • Furthermore, female plastic surgeons have a lower income than their male colleagues despite similar hours and practice profile.
  • Nevertheless, female plastic surgeons appear to have similar career satisfaction and are no more likely to retire earlier or more frequently than male plastic surgeons.
  • [MeSH-major] Career Choice. Physicians, Women / statistics & numerical data. Professional-Family Relations. Surgery, Plastic / manpower

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  • (PMID = 20489407.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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35. Cunha IW, Lopes A, Falzoni R, Soares FA: Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS. Appl Immunohistochem Mol Morphol; 2006 Dec;14(4):404-10
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  • [Title] Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS.
  • NO is produced by nitric oxide synthases (NOS).
  • There are three enzyme isoforms: two of them are constitutively produced (neuronal or brain NOS and endothelial NOS), and one is an inducible form (iNOS).
  • NOS expression has been shown in several epithelial tumors, but there is no report addressing NOS expression in sarcomas.
  • The authors evaluated the expression of NOS in 97 cases of various sarcomas spotted in duplicate in a tissue array paraffin block.
  • Only chondrosarcomas and liposarcomas had significant numbers of negative cases, and all pleomorphic sarcomas, alveolar soft part sarcomas, angiosarcomas, gastrointestinal stromal tumors, and synovial sarcomas showed some degree of positivity.
  • Forty-three cases (44.4%) showed eNOS immunostaining, but only 15.5% showed a strong signal, with emphasis on angiosarcomas, chondrosarcomas, alveolar soft part sarcomas, and synovial sarcoma.
  • Strong expression of iNOS was found in malignant peripheral nerve sheet tumors, liposarcomas, pleomorphic sarcomas, fibrosarcomas, chondrosarcomas, and synovial sarcomas.
  • Apparently alveolar soft part sarcomas are unusual in their capacity of expression of NOS isoforms, and in a very peculiar pattern.
  • In conclusion, sarcomas in general commonly express constitutive NOS, and only a few types of sarcomas can express iNOS, the isoenzymes capable of releasing large amounts of NO.
  • More comprehensive studies should be performed to better understand the clinical importance of NOS expression and NO production in sarcomas.

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  • (PMID = 17122636.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 1.14.13.39 / Nitric Oxide Synthase Type I; EC 1.14.13.39 / Nitric Oxide Synthase Type III
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36. Wu J, Brinker DA, Haas M, Montgomery EA, Argani P: Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy. Int J Surg Pathol; 2005 Jan;13(1):81-5
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  • [Title] Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy.
  • Alveolar soft part sarcoma (ASPS) is a rare neoplasm that most commonly presents in the lower extremities.
  • Although ASPS has distinctive histologic features, it may cause diagnostic problems when it arises in unusual locations.
  • To our knowledge, only 1 case of ASPS arising within the breast has previously been reported.
  • Here, we report a second case of primary mammary ASPS.
  • The excision more clearly revealed the lesion's alveolar architecture and demonstrated cells with more eosinophilic cytoplasm, along with the xanthomatous cells.
  • The diagnosis of ASPS was confirmed by electron microscopy, which revealed characteristic membrane-bound rhomboidal crystals, as well as by nuclear labeling for TFE3 protein by immunohistochemistry.
  • With this report, we confirm the utility of a novel immunohistochmical technique for the identification of an ASPS presenting in an unusual locale.
  • [MeSH-major] Breast Neoplasms / pathology. DNA-Binding Proteins. Deoxycytidine / analogs & derivatives. Sarcoma / secondary. Soft Tissue Neoplasms / pathology. Transcription Factors. Xanthomatosis / pathology

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  • (PMID = 15735860.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA88843
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antimetabolites, Antineoplastic; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / DNA-Binding Proteins; 0 / TFE3 protein, human; 0 / Transcription Factors; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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37. Lott S, Lopez-Beltran A, Montironi R, MacLennan GT, Cheng L: Soft tissue tumors of the urinary bladder Part II: malignant neoplasms. Hum Pathol; 2007 Jul;38(7):963-77
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  • [Title] Soft tissue tumors of the urinary bladder Part II: malignant neoplasms.
  • The second half of this two-part review will describe rare nonurothelial malignant tumors of the urinary bladder including leiomyosarcoma, rhabdomyosarcoma, angiosarcoma, malignant fibrous histiocytoma (undifferentiated sarcoma), primitive neuroectodermal tumor, malignant peripheral nerve sheath tumor, hemangiopericytoma, and alveolar soft-parts sarcoma.
  • Common clinical presentations, morphologic characteristics, and immunohistochemical features are described to aid the practicing pathologist in the identification of these entities.
  • [MeSH-major] Soft Tissue Neoplasms / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Hemangiopericytoma / pathology. Histiocytoma, Malignant Fibrous / pathology. Humans. Immunohistochemistry. Nerve Sheath Neoplasms / pathology. Neuroectodermal Tumors, Primitive / pathology. Sarcoma / pathology

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  • (PMID = 17574946.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 60
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38. Modritz D, Ladenstein R, Pötschger U, Amman G, Dieckmann K, Horcher E, Urban C, Meister B, Schmitt K, Jones R, Kaulfersch W, Haas H, Moser R, Stöllinger O, Peham M, Gadner H, Koscielniak E, Treuner J: Treatment for soft tissue sarcoma in childhood and adolescence. Austrian results within the CWS 96 study. Wien Klin Wochenschr; 2005 Mar;117(5-6):196-209
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  • [Title] Treatment for soft tissue sarcoma in childhood and adolescence. Austrian results within the CWS 96 study.
  • OBJECTIVE: The aim of the CWS 96 Study was to achieve an optimal treatment in children and adolescents with soft tissue sarcoma (STS) implementing a further refinement of risk-adapted allocation to chemotherapy, surgery and radiotherapy.
  • 59/89 patients had localised RMS-like (rhabdomayosarcoma) STS (EFS 73% +/- 7%), 14 had localised NON-RMS STS (EFS 54% +/- 16%) and 15 patients had metastatic disease at diagnosis (EFS 33% +/- 12%), 1 patient had fibromatosis.
  • The 3 year EFS according to histology in patients with RMS-like STS was 61% +/- 11% for RME (embryonal RMS ) (28 patients) and 71% +/- 15% for RMA (alveolar RMS) (10 patients).
  • [MeSH-major] Risk Assessment / methods. Sarcoma / mortality. Sarcoma / therapy
  • [MeSH-minor] Adolescent. Adult. Austria / epidemiology. Child. Child, Preschool. Cohort Studies. Disease-Free Survival. Female. Humans. Incidence. Infant. Infant, Newborn. Male. Prognosis. Risk Factors. Survival Analysis. Treatment Outcome

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  • [CommentIn] Wien Klin Wochenschr. 2005 Mar;117(5-6):176-9 [15875755.001]
  • (PMID = 15875759.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Austria
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39. Cecchetto G, Alaggio R, Dall'Igna P, Bisogno G, Ferrari A, Gigante C, Casanova M, Sotti G, Zanetti I, Carli M: Localized unresectable non-rhabdo soft tissue sarcomas of the extremities in pediatric age: results from the Italian studies. Cancer; 2005 Nov 1;104(9):2006-12
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  • [Title] Localized unresectable non-rhabdo soft tissue sarcomas of the extremities in pediatric age: results from the Italian studies.
  • BACKGROUND: Treatment of initially unresectable nonrhabdo soft tissue sarcomas (NRSTS) in pediatric age is debated, due to their different chemosensitivity.
  • Aggressive delayed surgery of residual disease, including compartmental resections, was recommended.
  • Chemosensitive (CTs) sarcomas, 21: synovial sarcoma, 11; extraosseous Ewing sarcomas, 5; primitive peripheral neuroectodermic tumors, 5.
  • Nonchemosensitive (CTns) sarcomas, 31: fibrosarcoma, 11; malignant peripheral nerve sheet tumors, 10; liposarcoma, 2; hemangiopericitoma adult type, 2; epithelioid sarcoma, 2; and alveolar soft part sarcoma, leiomyosarcoma, clear cell sarcoma, and sarcoma NOS, each 1.
  • Nineteen of 21 patients with CTs-NRSTS were alive without disease: the 5-year overall survival (OS) and progression-free survival (PFS) were 94.4% and 79.3%, respectively; 23 of 31 patients with CTns-NRSTS were alive without disease: 5-year OS and PFS were 75.3% and 68.3%, respectively.
  • Tumor size < 5 cm, distal site, and tumor grading for CTns sarcomas were often linked to a favorable outcome; no conclusive results were detected concerning age of the patients or T status of the tumor.
  • [MeSH-major] Extremities. Sarcoma / diagnosis

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 16161038.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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40. Kasashima S, Minato H, Kobayashi M, Ueda Y, Oda Y, Hashimoto S, Inoue M: Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors. APMIS; 2007 Jul;115(7):861-5
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  • [Title] Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors.
  • Alveolar soft part sarcoma (ASPS) is a rare tumor of uncertain histogenesis, mainly localized in the extremities.
  • ASPS originating in the uterine corpus is quite rare; only eight such cases have been reported in the literature.
  • We here present another case of ASPS found in the endometrium in a 50-year-old woman.
  • Metastatic malignant tumor, including ASPS from other organs, was excluded by physical examination and imaging modalities.
  • The tumor showed characteristic histological features of ASPS: alveolar architecture with fibrovascular septa and abundant eosinophilic granular cytoplasm with periodic acid-Schiff-positive crystalline material.
  • Diffuse nuclear immunoreactivity for TFE3, a marker recently reported to be specific for ASPS, further supported the diagnosis of ASPS.
  • [MeSH-major] Endometrial Neoplasms / diagnosis. Neprilysin / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Sarcoma, Alveolar Soft Part / diagnosis

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  • (PMID = 17614855.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / TFE3 protein, human; EC 3.4.24.11 / Neprilysin
  • [Number-of-references] 15
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41. Seitz G, Warmann SW, Vokuhl CO, Heitmann H, Treuner C, Leuschner I, Fuchs J: Effects of standard chemotherapy on tumor growth and regulation of multidrug resistance genes and proteins in childhood rhabdomyosarcoma. Pediatr Surg Int; 2007 May;23(5):431-9
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  • The aim of this study was to investigate the development of multidrug resistance in cell lines and in xenografts of alveolar and embryonal RMS treated according to the German Soft Tissue Sarcoma Study (CWS).
  • Alveolar and embryonal RMS cell lines were treated with Vincristine, Topotecan, Carboplatin, Actinomycin D, or Ifosfamide.
  • Nude mice (NMRI nu/nu, n = 10 per group) underwent xenotransplantation of human embryonal or alveolar RMS.
  • In the cell lines, an up-regulation of MDR-1 gene was found in alveolar rhabdomyosarcoma.
  • Standard chemotherapy of alveolar rhabdomyosarcoma resulted in a significant reduction of tumor growth (P < 0.05) in all groups.
  • RT-PCR revealed a MDR1-dependent mechanism in alveolar rhabdomyosarcoma.
  • [MeSH-major] Drug Resistance, Neoplasm / drug effects. Gene Expression Regulation, Neoplastic / drug effects. Genes, MDR / genetics. Multidrug Resistance-Associated Proteins / drug effects. Rhabdomyosarcoma, Alveolar / drug therapy. Rhabdomyosarcoma, Embryonal / drug therapy. Soft Tissue Neoplasms / drug therapy
  • [MeSH-minor] Analysis of Variance. Animals. Antineoplastic Agents / administration & dosage. Antineoplastic Agents / therapeutic use. Disease Models, Animal. Drug Administration Schedule. Female. Humans. Immunohistochemistry / methods. Mice. Mice, Nude. Neoplasm Proteins / drug effects. Polymerase Chain Reaction / methods. Xenograft Model Antitumor Assays

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  • (PMID = 17211591.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Multidrug Resistance-Associated Proteins; 0 / Neoplasm Proteins
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42. Lin WY, Schaid DJ: Identifying single-nucleotide polymorphisms responsible for the linkage signal of rheumatoid arthritis on chromosome 6 by joint modeling of linkage and association. BMC Proc; 2007;1 Suppl 1:S40
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  • We found that the LOD score for testing association in the presence of linkage dramatically increased when unrelated controls were added to affected sib pairs (ASPs), and that choosing a sufficient number of flanking markers is critical in order to distinguish between perfect linkage disequilibrium (which leads to the conclusion of a measured SNP explaining a linkage signal) and incomplete linkage disequilibrium (which leads to the conclusion of other undetected causal variants in a linkage region).

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  • (PMID = 18466539.001).
  • [ISSN] 1753-6561
  • [Journal-full-title] BMC proceedings
  • [ISO-abbreviation] BMC Proc
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM067768
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2367551
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43. Lineaweaver WC: Bad timing: the uncoupling of the American Society of Plastic Surgeons from the American College of Surgeons. Microsurgery; 2005;25(1):1-2
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  • [Title] Bad timing: the uncoupling of the American Society of Plastic Surgeons from the American College of Surgeons.

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  • (PMID = 15643659.001).
  • [ISSN] 0738-1085
  • [Journal-full-title] Microsurgery
  • [ISO-abbreviation] Microsurgery
  • [Language] eng
  • [Publication-type] Editorial
  • [Publication-country] United States
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44. Strunk T, Bastian PJ, Ellinger J, Biermann K, Müller SC: [Aggressive course of a malignant alveolar soft tissue sarcoma]. Urologe A; 2007 Oct;46(10):1422-4
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  • [Title] [Aggressive course of a malignant alveolar soft tissue sarcoma].
  • Alveolar soft part sarcoma is a rare soft tissue tumor.
  • Most patients who are affected by this sarcoma are between 15 and 35 years old.
  • Publications concerning this sarcoma subform are rare and the best therapeutic procedure is not yet clear.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Neoplasms, Second Primary / diagnosis. Sarcoma, Alveolar Soft Part / diagnosis
  • [MeSH-minor] Aged. Capillaries / pathology. Diagnosis, Differential. Disease Progression. Fatal Outcome. Humans. Lymph Node Excision. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Lymphoma, Non-Hodgkin / pathology. Male. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Radiotherapy, Adjuvant. Retreatment. Testicular Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 17641862.001).
  • [ISSN] 0340-2592
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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45. Flannery T, Kano H, Niranjan A, Monaco EA 3rd, Flickinger JC, Kofler J, Lunsford LD, Kondziolka D: Gamma knife radiosurgery as a therapeutic strategy for intracranial sarcomatous metastases. Int J Radiat Oncol Biol Phys; 2010 Feb 1;76(2):513-9
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  • The primary pathology was metastatic leiomyosarcoma (4 patients), osteosarcoma (3 patients), soft-tissue sarcoma (5 patients), chondrosarcoma (2 patients), alveolar soft part sarcoma (2 patients), and rhabdomyosarcoma, Ewing's sarcoma, liposarcoma, neurofibrosarcoma, and synovial sarcoma (1 patient each).
  • Twenty patients received multimodality management for their primary tumor, and 1 patient had no evidence of systemic disease.
  • Three patients had progressive intracranial disease despite fractionated whole-brain radiotherapy before SRS.
  • The median survival after diagnosis of intracranial metastasis was 16 months, and the 1-year survival rate was 61%.
  • However, many patients, including those who also received fractionated whole-brain radiotherapy, developed progressive new brain disease.
  • [MeSH-major] Brain Neoplasms / surgery. Radiosurgery. Sarcoma / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19467792.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. Stejskalová E, Jarosová M, Malis J, Sumerauer D, Urbánková H, Krsková L, Pýcha K, Schovanec J, Balcárková J, Smelhaus V, Kodetová D, Starý J: [Clinical relevance of chromosomal aberrations in bone and soft tissue tumors in children and young adults]. Klin Onkol; 2009;22(2):58-66
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  • [Title] [Clinical relevance of chromosomal aberrations in bone and soft tissue tumors in children and young adults].
  • BACKGROUND: We present the results of a cytogenetic and molecular cytogenetic analysis of a series of patients with bone and soft tissue tumors.
  • PATIENTS ANDMETHODS: We analyzed a cohort of 26 patients with Ewing sarcoma/PNET, 15 patients with rhabdomyosarcoma, 5 with synovial sarcoma and one patient with an undifferentiated sarcoma using the cytogenetic and molecular cytogenetic techniques M-FISH and arrayCGH.
  • In the RMS patients we detected the t(1;13)(p36;q14) once and the t(2;13)(q35;q14) four times, both of them characteristic for the alveolar subtype with poor prognosis and numerical aberrations, characteristic for the embryonal subtype, in five patients.
  • Four patients with synovial sarcoma had the diagnostic t(X;18)(p11.2;q11.2), one of them had a complex karyotype with a complex t(X;18;21) (p11.2;q11.2;q11.2) together with t(2;5)(q24-32;p13-14) and t(12;20)(p11;q13).
  • We correlated the karyotype of cancer cells with histopathologic morphologic analysis, clinical outcome and foreign published results.
  • CONCLUSION: Cytogenetic and molecular cytogenetic analysis is a valuable diagnostic tool in bone and soft tissue tumors, especially in less differentiated subtypes, and as such it should be an integral part of curative care.
  • [MeSH-major] Bone Neoplasms / genetics. Chromosome Aberrations. Soft Tissue Neoplasms / genetics

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  • (PMID = 19522375.001).
  • [ISSN] 0862-495X
  • [Journal-full-title] Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti
  • [ISO-abbreviation] Klin Onkol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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47. Fernández-Recio J, Abagyan R, Totrov M: Improving CAPRI predictions: optimized desolvation for rigid-body docking. Proteins; 2005 Aug 1;60(2):308-13
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  • The ICM Docking and Interface Side-Chain Optimization (ICM-DISCO) showed promising predictive results during the first CAPRI experiment by successfully finding medium- or high-accuracy models in 3 of the 7 targets.
  • For that, we have defined a new desolvation descriptor for rigid-body docking, based on atomic solvation parameters (ASPs) derived from octanol-water transfer experiments.

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  • (PMID = 15981266.001).
  • [ISSN] 1097-0134
  • [Journal-full-title] Proteins
  • [ISO-abbreviation] Proteins
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Macromolecular Substances
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48. Goldstein M, Meller I, Issakov J, Orr-Urtreger A: Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors. Neoplasia; 2006 May;8(5):332-43
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  • [Title] Novel genes implicated in embryonal, alveolar, and pleomorphic rhabdomyosarcoma: a cytogenetic and molecular analysis of primary tumors.
  • Rhabdomyosarcoma, the most common pediatric soft tissue sarcoma, likely results from deregulation of the skeletal myogenesis program.
  • Using a combined approach of spectral karyotyping, array-based comparative genomic hybridization (CGH), and expression analysis, we examined 10 primary RMS tumors, including embryonal, alveolar, and the rare adult pleomorphic variant, to explore the involvement of different genes and genetic pathways in RMS tumorigenesis.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Genetic Predisposition to Disease. Neoplasms / genetics. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Alveolar / metabolism. Rhabdomyosarcoma, Embryonal / embryology. Rhabdomyosarcoma, Embryonal / genetics


49. McIntosh SA, Horgan K: Augmentation mammoplasty: effect on diagnosis of breast cancer. J Plast Reconstr Aesthet Surg; 2008;61(2):124-9
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  • [Title] Augmentation mammoplasty: effect on diagnosis of breast cancer.
  • In the USA in 2003, a total of 254 140 breast augmentation procedures were carried out [American Society of Plastic Surgeons, http://www.plasticsurgery.org/news_room/Procedural-Statistics-Press-Kit-Index.cfm9-1-2005; 2006.(1)].
  • However, as the population of women with breast implants ages, an increasing number of them will develop breast cancer; a reflection of the fact that the incidence of the disease increases with increasing age.
  • We review the literature on the radiological and tissue diagnosis of breast cancer in women with a history of previous augmentation mammaplasty.
  • [MeSH-major] Breast Implantation. Breast Neoplasms / diagnosis

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  • (PMID = 18039600.001).
  • [ISSN] 1748-6815
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 60
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50. Cantacessi C, Campbell BE, Young ND, Jex AR, Hall RS, Presidente PJ, Zawadzki JL, Zhong W, Aleman-Meza B, Loukas A, Sternberg PW, Gasser RB: Differences in transcription between free-living and CO2-activated third-stage larvae of Haemonchus contortus. BMC Genomics; 2010 Apr 27;11:266
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  • BACKGROUND: The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide.
  • RESULTS: Totals of 101,305 (L3) and 105,553 (xL3) expressed sequence tags (ESTs) were determined using 454 sequencing technology, and then assembled and annotated; the most abundant transcripts encoded transthyretin-like, calcium-binding EF-hand, NAD(P)-binding and nucleotide-binding proteins as well as homologues of Ancylostoma-secreted proteins (ASPs).
  • CONCLUSION: The present study indicated that some key transcriptional alterations taking place during the transition from the L3 to the xL3 stage of H. contortus involve genes predicted to be linked to the development of neuronal tissue (L3 and xL3), formation of the cuticle (L3) and digestion of host haemoglobin (xL3).

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  • (PMID = 20420710.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide
  • [Other-IDs] NLM/ PMC2880303
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51. Armah HB, Parwani AV: Xp11.2 translocation renal cell carcinoma. Arch Pathol Lab Med; 2010 Jan;134(1):124-9
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  • These include a distinctive RCC that bears a translocation with the identical chromosomal breakpoints (Xp11.2, 17q25) and identical resulting ASPL-TFE3 gene fusion as alveolar soft part sarcoma.
  • [MeSH-minor] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Diagnosis, Differential. Humans. Oncogene Proteins, Fusion / genetics. Prognosis

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  • (PMID = 20073616.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
  • [Number-of-references] 30
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52. Shih PY, Wang T, Xing C, Sinha M, Song Y, Elston RC: Linkage analysis of alcohol dependence using both affected and discordant sib pairs. BMC Genet; 2005 Dec 30;6 Suppl 1:S36
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  • The basic idea of affected-sib-pair (ASP) linkage analysis is to test whether the inheritance pattern of a marker deviates from Mendelian expectation in a sample of ASPs.
  • To be robust to deviation from Mendelian transmission, here we analyzed Collaborative Study on the Genetics of Alcoholism data by modifying the ASP LOD score method to contrast the estimated distribution of the number of allele(s) shared IBD by ASPs with that by DSPs, instead of with the expected distribution under the Mendelian assumption.
  • This strategy assesses the difference in IBD sharing between ASPs and the IBD sharing between DSPs.

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  • (PMID = 16451646.001).
  • [ISSN] 1471-2156
  • [Journal-full-title] BMC genetics
  • [ISO-abbreviation] BMC Genet.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R37 GM028356; United States / NCRR NIH HHS / RR / P41 RR003655; United States / NIDDK NIH HHS / DK / DK-57292; United States / NCRR NIH HHS / RR / RR03655; United States / NIGMS NIH HHS / GM / GM28356; United States / NIDDK NIH HHS / DK / U01 DK057292; United States / NIGMS NIH HHS / GM / R01 GM028356
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC1866749
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53. Afshar AR, Abbasi F: Photoclinic. Primary alveolar soft part sarcoma of bone. Arch Iran Med; 2006 Apr;9(2):175-6, 181
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  • [Title] Photoclinic. Primary alveolar soft part sarcoma of bone.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Sarcoma, Alveolar Soft Part / surgery

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  • (PMID = 16649367.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
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54. Rao PK, Missiaglia E, Shields L, Hyde G, Yuan B, Shepherd CJ, Shipley J, Lodish HF: Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells. FASEB J; 2010 Sep;24(9):3427-37
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  • Rhabdomyosarcoma is the most common soft tissue sarcoma in the pediatric population.
  • As this tumor has an undifferentiated myogenic phenotype, agents that promote differentiation hold particular promise as part of a novel therapeutic approach to combat this type of cancer.
  • Levels of miR-1 and miR-133a are drastically reduced in representative cell lines from each major rhabdomyosarcoma subtype (embryonal and alveolar).

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  • (PMID = 20466878.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK068348; United Kingdom / Cancer Research UK / / C5066/A9541
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs
  • [Other-IDs] NLM/ PMC3231107
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55. Wang ZH, Shi HY, Wang ZB: [Metastatic alveolar soft tissue sarcoma of the central nervous system: a clinicopathological analysis of four cases]. Ai Zheng; 2009 Nov;28(11):1214-8
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  • [Title] [Metastatic alveolar soft tissue sarcoma of the central nervous system: a clinicopathological analysis of four cases].
  • BACKGROUND AND OBJECTIVE: Metastatic alveolar soft tissue sarcoma (ASTS) of the central nervous system is rare and is easy to be misdiagnosed as other primary tumors of central nervous system.
  • This study was to analyze the clinical and pathological features of four patients with ASTS of the central nervous system and to clarify their differential diagnosis as well as prognosis.
  • The tumor cells had clear or eosinophilic cytoplasm and prominent nucleoli, arranged in alveolar structures, which were surrounded by delicate blood sinuses.
  • [MeSH-major] Cranial Fossa, Posterior. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / secondary. Skull Base Neoplasms / pathology. Skull Base Neoplasms / secondary
  • [MeSH-minor] Actins / metabolism. Adult. Desmin / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Neoplasm Recurrence, Local. Paraganglioma / diagnosis. Prognosis. Rhabdomyosarcoma / diagnosis. S100 Proteins / metabolism. Survival Rate

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  • (PMID = 19895745.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins
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56. Liu PJ, Hsieh WT, Huang SH, Liao HF, Chiang BH: Hematopoietic effect of water-soluble polysaccharides from Angelica sinensis on mice with acute blood loss. Exp Hematol; 2010 Jun;38(6):437-45
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  • MATERIALS AND METHODS: The crude extract of Angelica sinensis (AS) was separated into two fractions, polysaccharides (ASPS) and small molecular weight compounds.
  • The AS, ASPS, and small molecular weight compounds were incubated with mice spleen cells to obtain conditioned mediums, and then their hematopoietic activities were evaluated by granulocyte macrophage (GM) colony-forming assay in vitro.
  • RESULTS: We found that polysaccharide (ASPS) was the major component responsible for the hematopoietic effect of Angelica sinensis.
  • Administration of low-dose ASPS (2.3 mg ASPS/kg body weight per day) could significantly accelerate the recovery of hemoglobin level of the blood-loss mice to its original value, as compared to the control (p < 0.05).
  • Moreover, the colony-forming ability of bone marrow cells that were removed from mice that received ASPS was also markedly increased (p < 0.05) during ex vivo test.
  • CONCLUSIONS: Results of this study demonstrated the potential of ASPS for treatment of anemia.

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  • [Copyright] Copyright 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20347925.001).
  • [ISSN] 1873-2399
  • [Journal-full-title] Experimental hematology
  • [ISO-abbreviation] Exp. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / Hematopoietic Cell Growth Factors; 0 / Plant Extracts; 0 / Polysaccharides; 059QF0KO0R / Water
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57. Linardic CM, Naini S, Herndon JE 2nd, Kesserwan C, Qualman SJ, Counter CM: The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence. Cancer Res; 2007 Jul 15;67(14):6691-9
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  • Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence.
  • Despite advances in therapy, patients with a histologic variant of rhabdomyosarcoma known as alveolar rhabdomyosarcoma (ARMS) have a 5-year survival of <30%.
  • This association between PAX3-FKHR expression and p16(INK4A) loss was seen in human ARMS tumor tissue, as both human rhabdomyosarcoma cell lines and tissue microarrays showed a trend toward down-regulation of p16(INK4A) protein in alveolar subsets.

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  • (PMID = 17638879.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12 HD043494; United States / NICHD NIH HHS / HD / 5K12 HD 043494; United States / NCI NIH HHS / CA / R01 CA 94184
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / FOXO1 protein, human; 0 / Forkhead Box Protein O1; 0 / Forkhead Transcription Factors; 0 / PAX3 Transcription Factor; 0 / PAX3 protein, human; 0 / Paired Box Transcription Factors; 0 / Recombinant Fusion Proteins
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58. Mentzel T, Kuhnen C: Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch; 2006 Nov;449(5):554-60
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  • Rhabdomyosarcoma (RMS) is currently classified into embryonal RMS, including its botryoid and spindle cell variants, alveolar RMS, including a solid variant, and pleomorphic RMS.
  • In children and adolescents embryonal RMS occurs in a younger age group than alveolar RMS, and pleomorphic RMS is almost always seen in older adults.
  • All neoplasms arose in subcutaneous and deep soft tissues with dermal involvement in one case, and the size of the neoplasms ranged from 4 to 19 cm in largest diameter.
  • Follow-up information was available in five patients (range from 10 to 48 months) and revealed lung metastases in two patients who died of disease within a short period.
  • Immunohistochemically, tumour cells in RMS stain positively for CD 99 and WT1 as well, which is of importance in the differential diagnosis to other mesenchymal neoplasms, whereas fast myosin does not represent a reliable marker for RMS in adults.
  • [MeSH-major] Rhabdomyosarcoma / pathology. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17013628.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD99; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules
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59. Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C: Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma. Cancer Res; 2009 Apr 1;69(7):2902-11
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  • [Title] Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.
  • The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma of childhood, yet the outcome for the unresectable and metastatic disease is dismal and unchanged for nearly three decades.
  • To better understand the pathogenesis of this disease and to facilitate novel preclinical approaches, we previously developed a conditional mouse model of ARMS by faithfully recapitulating the genetic mutations observed in the human disease, i.e., activation of Pax3:Fkhr fusion gene with either p53 or Cdkn2a inactivation.
  • In this report, we show that this model recapitulates the immunohistochemical profile and the rapid progression of the human disease.

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  • (PMID = 19339268.001).
  • [ISSN] 1538-7445
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA074907-06; United States / NCI NIH HHS / CA / CA090438-06; United States / NCI NIH HHS / CA / CA064202-07; United States / NCI NIH HHS / CA / CA064202-13; United States / NCI NIH HHS / CA / R01 CA064202-08S1; United States / NCI NIH HHS / CA / P30CA54174; United States / NCI NIH HHS / CA / R01 CA064202-11; United States / NCI NIH HHS / CA / CA064202-08S1; United States / NCI NIH HHS / CA / R01 CA074907-09; United States / NCI NIH HHS / CA / K08 CA090438; United States / NCI NIH HHS / CA / CA074907-11; United States / NCI NIH HHS / CA / CA64202; United States / NCI NIH HHS / CA / R01 CA064202-06; United States / NCI NIH HHS / CA / R01 CA074907; United States / NCI NIH HHS / CA / CA064202-08; United States / NCI NIH HHS / CA / CA074907-07; United States / NCI NIH HHS / CA / R01 CA064202-14; United States / NCI NIH HHS / CA / R01 CA064202-13; United States / NCI NIH HHS / CA / R01 CA064202-07; United States / NCI NIH HHS / CA / R29 CA074907; United States / NCI NIH HHS / CA / CA074907-08; United States / NCI NIH HHS / CA / R01 CA064202-09; United States / NCI NIH HHS / CA / R01 CA064202; United States / NCI NIH HHS / CA / CA074907; United States / NCI NIH HHS / CA / CA074907-10A1; United States / NCI NIH HHS / CA / CA064202-11; United States / NCI NIH HHS / CA / CA074907-09; United States / NCI NIH HHS / CA / CA074907-06; United States / NCI NIH HHS / CA / R01 CA064202-08; United States / NCI NIH HHS / CA / R01 CA074907-11; United States / NCI NIH HHS / CA / CA064202-14; United States / NCI NIH HHS / CA / CA064202-10A1; United States / NCI NIH HHS / CA / R01 CA074907-07; United States / NCI NIH HHS / CA / P30 CA054174; United States / NCI NIH HHS / CA / CA064202-12; United States / NCI NIH HHS / CA / R01 CA074907-08; United States / NCI NIH HHS / CA / CA064202-06; United States / NCI NIH HHS / CA / R01 CA064202-12; United States / NCI NIH HHS / CA / K08 CA090438-06; United States / NCI NIH HHS / CA / R01 CA064202-10A1; United States / NCI NIH HHS / CA / CA064202-09; United States / NCI NIH HHS / CA / R01 CA074907-10A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn2a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Forkhead Transcription Factors; 0 / Foxo1 protein, mouse; 0 / Oncogene Proteins, Fusion; 0 / PAX3-FKHR fusion protein, human; 0 / Paired Box Transcription Factors; 0 / Tumor Suppressor Protein p53; 138016-91-8 / Pax3 protein, mouse
  • [Other-IDs] NLM/ NIHMS96027; NLM/ PMC2789740
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60. Rohrich RJ: The 10-year American Society of Plastic Surgeons' history update. Plast Reconstr Surg; 2006 Oct;118(5 Suppl):1S
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The 10-year American Society of Plastic Surgeons' history update.
  • [MeSH-major] Societies, Medical / history. Surgery, Plastic

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  • (PMID = 17006312.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Editorial; Historical Article
  • [Publication-country] United States
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61. Okoro SA, Barone C, Bohnenblust M, Wang HT: Breast reduction trend among plastic surgeons: a national survey. Plast Reconstr Surg; 2008 Nov;122(5):1312-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast reduction trend among plastic surgeons: a national survey.
  • The authors' goal was to survey members of the American Society of Plastic Surgeons to identify their preferences and practices and report their opinion regarding issues related to the various breast reduction techniques.
  • METHODS: In the fall of 2006, a one-page anonymous survey was sent to 5112 plastic surgeons who were members of the American Society of Plastic Surgeons.
  • RESULTS: Of the 5112 plastic surgeons surveyed, 2665 (52 percent) responded to the survey.
  • Plastic surgeons are becoming more cognizant of the risk of deep venous thrombosis among their patients.
  • [MeSH-major] Mammaplasty / trends. Professional Practice / trends. Surgery, Plastic / trends

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  • (PMID = 18971713.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Villani F, Caviggioli F, Giannasi S, Klinger M, Klinger F: Current applications and safety of autologous fat grafts: a report of the ASPS Fat Graft Task Force. Plast Reconstr Surg; 2010 Feb;125(2):758-9; author reply 759
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  • [Title] Current applications and safety of autologous fat grafts: a report of the ASPS Fat Graft Task Force.
  • [MeSH-major] Adipose Tissue / transplantation. Evidence-Based Medicine. Practice Guidelines as Topic. Reconstructive Surgical Procedures / standards. Surgery, Plastic / standards

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  • [CommentOn] Plast Reconstr Surg. 2009 Jul;124(1):272-80 [19346997.001]
  • (PMID = 20124871.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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63. Lazar AJ, Lahat G, Myers SE, Smith KD, Zou C, Wang WL, Lopez-Terrada D, Lev D: Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray. Histopathology; 2009 Dec;55(6):750-5
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  • [Title] Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray.
  • AIMS: The molecular signature of alveolar soft part sarcoma (ASPS) is a specific der(17)t(X;17)(p11.2;q25) translocation, resulting in a chimeric transcription factor (ASPSCR1-TFE3).
  • When this disease is no longer amenable to surgical curative intervention, uniformly efficacious therapies are lacking.
  • The aim of this study was to evaluate the expression of potential molecular therapeutic targets in a cohort of ASPS tumour samples.
  • METHODS AND RESULTS: Immunohistochemical analysis for hepatocyte growth factor, c-Met, phosphorylated c-Met, phosphorylated AKT, phosphorylated MEK, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), p53 and vimentin was performed on an ASPS tissue microarray, yielding complete data from 26 tumours.
  • CONCLUSIONS: There is a crucial need for better anti-ASPS therapies.
  • [MeSH-major] Neoplasm Proteins / metabolism. Sarcoma, Alveolar Soft Part / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Tissue Array Analysis


64. Miron I, Miron L, Dumitraş S, Aprodu G, Ciobanu A, Tansanu I: [Statistical study of the evolution over ten years of the clinical and therapeutic approach in childhood soft tissue sarcoma]. Rev Med Chir Soc Med Nat Iasi; 2007 Apr-Jun;111(2):358-62
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  • [Title] [Statistical study of the evolution over ten years of the clinical and therapeutic approach in childhood soft tissue sarcoma].
  • [Transliterated title] Studiul statistic clinico-terapeutic si evolutiv pe 10 ani in sarcoamele de tesuturi moi la copii si tineri.
  • Soft tissue sarcoma has a primitive mesenchymal origin and represents a heterogeneous group of malignant entities with a continuous rising frequency in the age range below 18.
  • We included in the study a well-known category of soft tissue tumors called of uncertain malignancy.
  • Maria" Clinical Emergency Hospital Iaşi on a group of 58 de patients ranging between 0 and 18 years old.
  • Based on histological examination 19 cases (32.75%) were of rhabdomyosarcoma type with following subtypes: alveolar--7 patients, embryonic-- 9 cases, fusiform - 2 cases, bothrioid--1 case), 8 cases were undifferentiated soft tissue sarcomas and one patient had a tumor of pleiomorphic type; 13 children (22.41%) had non-rhabdomyosarcoma soft tissue sarcomas: 6 fibrosarcomas, 2 synovial sarcomas, 1 leiomyosarcoma, 1 Kaposi sarcoma, 1 case of malignant peripheral nerve sheath tumor, 1 case of angioma tumor, one liposarcoma; 16 cases were included in soft tissue tumors of uncertain origin (fibromatosis--6 cases, fibrous histiocytoma--4 cases, hamartoma--cases, myoblastoma--1 case, fibro-xanthoma--1 case, hemangioendothelioma--1 case); 1 PPNET (Askin tumor).
  • CONCLUSIONS: The continuously augmented incidence of soft tissue sarcoma in young ages and the advanced stages initial presentations of tumors require a much more serious and rhythmic survey at general practitioner level.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / therapy. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / therapy

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  • (PMID = 17983168.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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65. Thway K, Rockcliffe S, Gonzalez D, Swansbury J, Min T, Thompson L, Fisher C: Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre. J Clin Pathol; 2010 Jun;63(6):508-12
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  • [Title] Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre.
  • AIMS: Diagnosis of soft tissue sarcomas can be difficult.
  • This study assessed the utility of a molecular genetics/cytogenetics service as part of the routine diagnostic service at the Royal Marsden Hospital.
  • METHODS: A retrospective audit was performed over a 15-month period to evaluate the diagnostic usefulness for soft tissue sarcomas with translocations of fluorescence in situ hybridisation (FISH) and reverse-transcriptase PCR (RT-PCR) in paraffin-embedded (PE) material.
  • RESULTS: Molecular investigations were performed on PE material in 158 samples (total 194 RT-PCR and 174 FISH tests), of which 85 were referral cases.
  • Synovial sarcoma, Ewing sarcoma and low-grade fibromyxoid sarcoma were the most commonly tested tumours.
  • Myxoid liposarcoma showed the best histological and molecular concordance, and alveolar rhabdomyosarcoma showed the best agreement between methods.
  • FISH had a higher sensitivity for detecting tumours (73%, compared with 59% for RT-PCR) with a better success rate than RT-PCR, although the latter was specific in identifying the partner gene for each fusion.
  • In particular, referral blocks in which methods of tissue fixation and processing were not certain resulted in higher RT-PCR failure rates.
  • CONCLUSIONS: FISH and RT-PCR on PE tissue are practical and effective ancillary tools in the diagnosis of soft tissue sarcomas.
  • PCR is less sensitive than FISH, and the use of both techniques is optimal for maximising the detection rate of translocation-positive sarcomas.
  • [MeSH-major] Oncogene Fusion. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Epidemiologic Methods. Humans. In Situ Hybridization, Fluorescence / methods. Paraffin Embedding. Reverse Transcriptase Polymerase Chain Reaction / methods. Translocation, Genetic


66. Aulmann S, Longerich T, Schirmacher P, Mechtersheimer G, Penzel R: Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. Histopathology; 2007 Jun;50(7):881-6
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  • [Title] Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.
  • AIMS: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, non-reciprocal translocation der(17)t(X;17)(p11.2;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TFE3.
  • Although diagnosis is straightforward in classical cases, tumours with atypical morphological features may be difficult to classify solely on the basis of conventional histopathology.
  • The aim of this study was to analyse the chromosomal breakpoints in paraffin-embedded tissue.
  • METHODS AND RESULTS: Three male and two female ASPS patients including one case with uncommon histology were investigated by fluorescence in situ hybridization with split- and fusion-probes.
  • Hybridization results showed a t(X;17)(p11.2;q25) in all tumours with a duplication of the telomeric part of chromosome Xp.
  • CONCLUSIONS: Molecular confirmation of ASPSCR1-TFE3 gene fusion is applicable to routinely processed archival and diagnostic tumour samples and aids in the differential diagnosis of ASPS.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Neoplasm Proteins / genetics. Oncogene Fusion. Oncogene Proteins, Fusion / genetics. Sarcoma, Alveolar Soft Part / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 17543078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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67. Khanna P, Paidas CN, Gilbert-Barness E: Alveolar soft part sarcoma: clinical, histopathological, molecular, and ultrastructural aspects. Fetal Pediatr Pathol; 2008;27(1):31-40
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  • [Title] Alveolar soft part sarcoma: clinical, histopathological, molecular, and ultrastructural aspects.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor occurring mainly in the adolescents and young adults.
  • The histopathological, ultrastructural, immunohistochemical, and genetic aspects of ASPS are discussed.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18568987.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / S100 Proteins; 0 / Synaptophysin
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68. Morris WR, Padgett DM, Osborn FD, Fleming JC: Pathologic quiz case: an orbital mass in a 45-year-old woman. Alveolar soft part sarcoma. Arch Pathol Lab Med; 2005 Apr;129(4):534-6
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  • [Title] Pathologic quiz case: an orbital mass in a 45-year-old woman. Alveolar soft part sarcoma.
  • [MeSH-major] Orbital Neoplasms / pathology. Sarcoma, Alveolar Soft Part / pathology

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  • (PMID = 15794682.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Kebudi R, Ayan I, Görgün O, Ağaoğlu FY, Vural S, Darendeliler E: Brain metastasis in pediatric extracranial solid tumors: survey and literature review. J Neurooncol; 2005 Jan;71(1):43-8
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  • The diagnosis was sarcomas in 12 patients: 5 osteosarcomas, 4 Ewing's sarcoma family tumors, 1 rhabdomyosarcoma, 1 clear cell sarcoma of the soft tissue, 1 alveolar soft part sarcoma.
  • Four patients (25%) had brain metastasis at diagnosis.
  • Twelve (75%) developed brain metastasis during therapy or relapse at a median duration of 16 (1-70) months from initial diagnosis.
  • Treatment included surgery, followed by postoperative radiotherapy (RT) and chemotherapy (CT) in 1, S and RT in 1, S in 1, RT and CT in 6, RT in 1, CT in 1 and no treatment in 5.
  • Only one patient with alveolar soft part sarcoma is alive with disease 20 months from diagnosis of brain metastasis.
  • Although, the outcome for these patients is dismal in this series and in the literature; reports of long term survival in a few cases with Wilms' tumor, osteosarcoma and alveolar soft part sarcoma who had isolated brain metastasis, suggest that a subset of patients may benefit from therapy.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / secondary. Sarcoma / epidemiology. Sarcoma / secondary

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  • (PMID = 15719274.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 43
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70. D'Amico RA, Saltz R, Rohrich RJ, Kinney B, Haeck P, Gold AH, Singer R, Jewell ML, Eaves F 3rd: Risks and opportunities for plastic surgeons in a widening cosmetic medicine market: future demand, consumer preferences, and trends in practitioners' services. Plast Reconstr Surg; 2008 May;121(5):1787-92
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  • [Title] Risks and opportunities for plastic surgeons in a widening cosmetic medicine market: future demand, consumer preferences, and trends in practitioners' services.
  • BACKGROUND: The American Society of Plastic Surgeons and the American Society for Aesthetic Plastic Surgery launched a joint Cosmetic Medicine Task Force to address the growing trend of non-plastic surgeons entering the cosmetic medicine field.
  • The task force commissioned two surveys in 2007 to determine consumer attitudes about choosing cosmetic medicine providers and to learn about the cosmetic services that plastic surgeons offer.
  • RESULTS: Compared with other practitioners, plastic surgeons enjoy higher rates of satisfaction among their patients who undergo noninvasive procedures.
  • Injectables present a particularly promising market for plastic surgeons.
  • Half of consumers surveyed said they were very concerned about complications associated with injectables, and generally, the higher the perceived risk of the procedure, the higher the likelihood that a patient would choose a plastic surgeon to perform it.
  • However, almost half of consumers said that if they had a positive experience with a non-plastic surgeon core provider for a noninvasive procedure, that physician would likely be their first choice for a surgical procedure.
  • CONCLUSIONS: These findings suggest that plastic surgeons, and especially those who are building young practices, must expand their offerings of nonsurgical cosmetic services to remain at the core of the cosmetic medicine field.
  • [MeSH-major] Consumer Behavior. Delivery of Health Care / trends. Health Services Needs and Demand / trends. Marketing of Health Services / trends. Surgery, Plastic / trends

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  • (PMID = 18454004.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Hoshino M, Ogose A, Kawashima H, Izumi T, Hotta T, Hatano H, Morita T, Otsuka H, Umezu H, Yanoma S, Tsukuda M, Endo N: Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma. Cancer Genet Cytogenet; 2009 Apr 15;190(2):75-80
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  • [Title] Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a distinct, rare soft tissue tumor with an unknown histogenesis and a tendency for late widespread metastases to lung, bone, and brain.
  • It is now clear that they are caused by a specific unbalanced translocation, der(17)t(X;17)(p11;q25), which results in the formation of an ASPSCR1-TFE3 (alias ASPL-TFE3) fusion gene.
  • The rearrangement results in the expression of chimeric transcripts, which can be identified by means of reverse transcriptase-polymerase chain reaction (RT-PCR).
  • We investigated the histogenesis of ASPS and attempted to detect circulating ASPS tumor cells in peripheral blood.
  • The immunohistochemical and genetic details of four cases and one cell line of ASPS were examined.
  • An immunohistochemical analysis and RT-PCR did not detect myogenic differentiation gene MYOD1.
  • The sensitivity of nested RT-PCR for detection of circulating ASPS cells was assessed by demonstrating that the tumor cell-associated gene translocation could be detected in 50 tumor cells/2 mL of blood.
  • Clinically, it was detectable in a peripheral blood sample (2 mL) of ASPS patient with distant metastases.
  • The findings suggest that ASPS is not of skeletal muscle origin.
  • ASPS tumor cells in the peripheral blood could be monitored by RT-PCR.
  • [MeSH-major] Neoplastic Cells, Circulating. Sarcoma, Alveolar Soft Part / pathology

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  • (PMID = 19380023.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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72. Roma AA, Yang B, Senior ME, Goldblum JR: TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report. Int J Gynecol Pathol; 2005 Apr;24(2):131-5
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  • [Title] TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report.
  • SUMMARY: : Alveolar soft part sarcoma (ASPS) is an uncommon neoplasm that has only rarely been reported in the female genital tract.
  • We report a case of incidentally discovered ASPS in the uterine cervix of a 39-year-old woman that exhibited immunoreactivity for TFE3, a recently described marker of ASPS.
  • Strong nuclear immunoreactivity for TFE3 in tumors characterized by a chromosomal translocation involving the TFE3 gene has been reported in ASPS and a subset of pediatric renal cell carcinomas.
  • To the best of our knowledge, this is the first report of ASPS of the female genital tract with immunoreactivity for TFE3.
  • [MeSH-major] Biomarkers, Tumor / analysis. DNA-Binding Proteins / metabolism. Sarcoma, Alveolar Soft Part / pathology. Transcription Factors / metabolism. Uterine Neoplasms / pathology

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  • (PMID = 15782069.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TFE3 protein, human; 0 / Transcription Factors
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73. Huh WW, Skapek SX: Childhood rhabdomyosarcoma: new insight on biology and treatment. Curr Oncol Rep; 2010 Nov;12(6):402-10
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  • Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood.
  • The two most common histologic variants are the embryonal and alveolar subtypes.
  • Although successive collaborative group clinical trials have improved survival rates for many RMS patients, the outcome for those patients with metastatic or recurrent disease remains poor.
  • Recent studies have pointed to a possible mesenchymal stem cell as the progenitor for alveolar RMS.
  • [MeSH-major] Rhabdomyosarcoma, Alveolar / diagnosis. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Alveolar / therapy. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / genetics. Rhabdomyosarcoma, Embryonal / therapy. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Animals. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Child. Child, Preschool. Clinical Trials as Topic. Combined Modality Therapy. Disease Progression. Female. Humans. Male. Mesenchymal Stromal Cells / pathology. Mice. Neoplasm Metastasis. Neoplasm Staging. Neoplastic Stem Cells / metabolism. Neoplastic Stem Cells / pathology. Prognosis. Protein Kinase Inhibitors / administration & dosage. Risk Factors. Secondary Prevention. Signal Transduction / drug effects. Signal Transduction / genetics. Sirolimus / administration & dosage. Survival Rate. TOR Serine-Threonine Kinases / antagonists & inhibitors. Tomography

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  • (PMID = 20820958.001).
  • [ISSN] 1534-6269
  • [Journal-full-title] Current oncology reports
  • [ISO-abbreviation] Curr Oncol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; EC 2.7.1.1 / TOR Serine-Threonine Kinases; W36ZG6FT64 / Sirolimus
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74. Zhu FP, Lu GM, Zhang LJ, Wang JD, An XJ, Dong YC: Primary alveolar soft part sarcoma of vertebra: a case report and literature review. Skeletal Radiol; 2009 Aug;38(8):825-9
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  • [Title] Primary alveolar soft part sarcoma of vertebra: a case report and literature review.
  • Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor, which rarely occurs in bone.
  • We present a case of ASPS in a 23-year-old man with a 2-month history of back pain.
  • Computed tomography scanning and magnetic resonance images demonstrated a destructive process in the 12th thoracic vertebra associated with a unilateral soft tissue mass.
  • The tumor showed evidence of hypervascularity on MRI; it obviously was enhanced on T1-weighted images after injection of Gd-GDPA, and signal voids were shown on all pulse sequences which may help to differentiate ASPS from other tumors of the vertebra.
  • We believe that this is the first case of ASPS arising in a vertebra.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Magnetic Resonance Imaging / methods. Spinal Neoplasms / diagnosis. Thoracic Vertebrae / diagnostic imaging. Thoracic Vertebrae / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 19347336.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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75. Tang Z, Mallikaratchy P, Yang R, Kim Y, Zhu Z, Wang H, Tan W: Aptamer switch probe based on intramolecular displacement. J Am Chem Soc; 2008 Aug 27;130(34):11268-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Both of these ASPs presented excellent selectivity and prompt response toward their targets.

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  • (PMID = 18680291.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aptamers, Nucleotide; 0 / DNA Probes; 0 / DNA, Complementary; 0 / Fluorescent Dyes; 30IQX730WE / Polyethylene Glycols; 8L70Q75FXE / Adenosine Triphosphate; 9007-49-2 / DNA; EC 3.4.21.5 / Thrombin
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76. Campbell B, Seymour JF, Wheeler G, Sexton M: Alveolar soft-part sarcoma: a cardiac metastasis as a rare site of relapse. Am J Clin Oncol; 2006 Aug;29(4):422-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma: a cardiac metastasis as a rare site of relapse.
  • [MeSH-major] Heart Neoplasms / secondary. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 16891875.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Kohashi K, Oda Y, Yamamoto H, Tamiya S, Takahira T, Takahashi Y, Tajiri T, Taguchi T, Suita S, Tsuneyoshi M: Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype. J Cancer Res Clin Oncol; 2008 Oct;134(10):1097-103
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  • [Title] Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype.
  • PURPOSE: Rhabdomyosarcoma (RMS), which is the most common pediatric soft tissue sarcoma, is classified into two major histologic subtypes, embryonal RMS (ERMS) and alveolar RMS (ARMS).
  • In addition, immunohistochemical pRB LI may have the potential to be a useful ancillary tool in the differential diagnosis of RMS subtypes.
  • [MeSH-major] Retinoblastoma Protein / biosynthesis. Retinoblastoma Protein / genetics. Rhabdomyosarcoma, Alveolar / diagnosis. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Embryonal / diagnosis. Rhabdomyosarcoma, Embryonal / genetics
  • [MeSH-minor] Base Sequence. Diagnosis, Differential. Gene Expression. Humans. Immunohistochemistry. Mutation. Reverse Transcriptase Polymerase Chain Reaction


78. Baglam T, Kalender ME, Durucu C, Bakir K, Karatas E, Kara F, Kanlikama M: Alveolar soft part sarcoma of the tongue. J Craniofac Surg; 2009 Nov;20(6):2160-2
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  • [Title] Alveolar soft part sarcoma of the tongue.
  • Alveolar soft part sarcoma is a rare type of sarcoma that usually affects young adult women.
  • Herein, we present an unusual case of alveolar soft part sarcoma of the tongue in an 18-year-old woman.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Tongue Neoplasms / pathology

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  • (PMID = 19884839.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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79. Messieha Z, Cruz-Gonzalez W, Hakim MI: Retrospective outcomes evaluation of 100 parenteral moderate and deep sedations conducted in a general practice dental residency. Anesth Prog; 2008;55(4):116-20
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  • An abstract of this study was presented at the American Association for Dental Research (AADR) Dental Anesthesiology Research Group in Honolulu, Hawaii, in March of 2004.
  • This study was conducted to correlate the intraoperative and postoperative morbidity associated with moderate and deep sedation, also known as monitored anesthesia care (MAC), provided in a General Practice Residency (GPR) clinic under the supervision of a dentist anesthesiologist.
  • Eleven morbidity criteria were assessed and were correlated with patient age, gender, American Society of Anesthesiology Physical Status Classification (ASAPS), duration of procedure, and anesthetic protocol.
  • No ASPS IV or V was noted.

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  • (PMID = 19108595.001).
  • [ISSN] 0003-3006
  • [Journal-full-title] Anesthesia progress
  • [ISO-abbreviation] Anesth Prog
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Dissociative; 0 / Anesthetics, Intravenous; 0 / Antiemetics; 4AF302ESOS / Ondansetron; 690G0D6V8H / Ketamine; R60L0SM5BC / Midazolam; YI7VU623SF / Propofol
  • [Other-IDs] NLM/ PMC2614649
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80. Biernacka JM, Cordell HJ: Exploring causality via identification of SNPs or haplotypes responsible for a linkage signal. Genet Epidemiol; 2007 Nov;31(7):727-40
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  • In a small chromosomal region, a number of polymorphisms may be both linked to and associated with a disease.
  • Recently, several methods have been proposed to aid in the identification of disease associated polymorphisms that may explain an observed linkage signal, using genotype data from affected sib pairs (ASPs) [Li et al. [2005] Am. J. Hum. Genet.
  • We extend variations of these methods to test for complete LD between a disease locus and haplotypes composed of two or more tightly linked candidate SNPs.
  • We study properties of the proposed methods by simulation and apply them to type 1 diabetes data for ASPs and their parents at candidate SNP and microsatellite marker loci in the Insulin (INS) gene region.

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  • [Cites] Genet Epidemiol. 2000;19 Suppl 1:S64-70 [11055372.001]
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  • (PMID = 17508343.001).
  • [ISSN] 0741-0395
  • [Journal-full-title] Genetic epidemiology
  • [ISO-abbreviation] Genet. Epidemiol.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 074524
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insulin
  • [Other-IDs] NLM/ PMC2682330
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81. Suvilampi J, Lehtomäki A, Rintala J: Comparative study of laboratory-scale thermophilic and mesophilic activated sludge processes. Water Res; 2005 Mar;39(5):741-50
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  • Laboratory-scale mesophilic (20-35 degrees C) and thermophilic (55 degrees C) activated sludge processes (ASPs) treating diluted molasses wastewater were compared in effluent quality, removal of different COD fractions, sludge yield, floc size, and sludge settleability.
  • In the ASPs, the hydraulic retention time was 12h in both processes, corresponding to a volumetric loading rate of 3.2+/-1.0 kg COD(filt) m(-3)d(-1).
  • Both ASPs gave high (90%) COD(sol) removals.

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  • (PMID = 15743618.001).
  • [ISSN] 0043-1354
  • [Journal-full-title] Water research
  • [ISO-abbreviation] Water Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Sewage; 1327-41-9 / aluminum oxychloride; 5QB0T2IUN0 / Aluminum Hydroxide; S88TT14065 / Oxygen
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82. Tanas MR, Rubin BP, Tubbs RR, Billings SD, Downs-Kelly E, Goldblum JR: Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience. Arch Pathol Lab Med; 2010 Dec;134(12):1797-803
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  • [Title] Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience.
  • OBJECTIVE: To determine the utility of FISH in the diagnosis of mesenchymal neoplasms.
  • DESIGN: Two hundred thirty soft tissue cases analyzed by FISH were reviewed retrospectively.
  • RESULTS: Morphologic patterns where FISH was used included high-grade round cell sarcomas (n  =  67), nonmyogenic spindle cell sarcomas (n  =  40), low-grade myxoid neoplasms (n  =  34), adipocytic neoplasms (n  =  20), and melanocytic neoplasms (n  =  19).
  • SYT FISH (96% of monophasic synovial sarcomas were positive; 0% of malignant peripheral nerve sheath tumor were positive) and DDIT3 FISH (100% of myxoid/round cell liposarcomas; no other neoplasm positive) were very sensitive and specific.
  • EWSR1 FISH was very sensitive and specific in the differential diagnosis of melanocytic neoplasms (88% of clear cell sarcomas were positive; all melanomas were negative).
  • EWSR1 FISH was sensitive among high-grade round cell sarcomas (positive in 100% of desmoplastic small round cell tumors and 96% of Ewing sarcoma/primitive neuroectodermal tumors) but not specific because clear cell sarcoma, extraskeletal myxoid chondrosarcoma, and a subset of round cell liposarcomas also harbor rearrangements of EWSR1.
  • FUS FISH was very sensitive in detecting low-grade fibromyxoid sarcomas (91% positive) but not specific because most myxoid/round cell liposarcomas also contain rearrangements of FUS.
  • FOXO1A FISH was positive in ∼70% of cases of alveolar rhabdomyosarcoma.
  • CONCLUSION: FISH is a useful adjunct in the diagnosis of mesenchymal neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Melanoma / diagnosis. Neoplasms, Adipose Tissue / diagnosis. Sarcoma / diagnosis. Soft Tissue Neoplasms / diagnosis


83. Lin YY, Hsieh TC, Kao CH, Wang CH, Wu YC, Yen KY, Sun SS: Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma. Clin Nucl Med; 2009 Nov;34(11):806-7
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  • [Title] Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / radionuclide imaging. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / radionuclide imaging

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  • (PMID = 19851182.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Stachowski J, Botts K, Rine L, Kato D, Pollock J: Mesotherapy: cosmetic applications. Int J Pharm Compd; 2006 Sep-Oct;10(5):331-4
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  • Mainly owing to the absence of safety and efficacy data pertaining to mesotherapy, liposuction is currently the only method for fat removal that is endorsed by the American Society of Plastic Surgeons .

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  • (PMID = 23974310.001).
  • [ISSN] 1092-4221
  • [Journal-full-title] International journal of pharmaceutical compounding
  • [ISO-abbreviation] Int J Pharm Compd
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Drew RH: Antimicrobial stewardship programs: how to start and steer a successful program. J Manag Care Pharm; 2009 Mar;15(2 Suppl):S18-23
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  • BACKGROUND: Antimicrobial stewardship programs (ASPs) promote the appropriate use of antimicrobials by selecting the appropriate dose, duration, and route of administration.
  • Other supplemental strategies involve education, guidelines and clinical pathways, antimicrobial order forms, de-escalation of therapy, intravenous-to-oral (IV-to-PO) switch therapy, and dose optimization.
  • Several barriers exist to successful implementation of ASPs.
  • CONCLUSION: ASPs have the potential to reduce antimicrobial resistance, health care costs, and drug-related adverse events while improving clinical outcomes.
  • The efforts and expense required to implement and maintain ASPs are more than justified given their potential benefits to both the hospital and the patient.


86. Hallock GG, Hallock EA: The Venus de Milo: an icon of reconstructive surgery and the American Society of Plastic Surgeons. Plast Reconstr Surg; 2005 Jun;115(7):2074-9
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  • [Title] The Venus de Milo: an icon of reconstructive surgery and the American Society of Plastic Surgeons.
  • [MeSH-major] Emblems and Insignia. Sculpture. Societies, Medical. Surgery, Plastic

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  • (PMID = 15923858.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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87. Sidi V, Fragandrea I, Hatzipantelis E, Kyriakopoulos C, Papanikolaou A, Bandouraki M, Koliouskas DE: Alveolar soft-part sarcoma of the extremity: a case report. Hippokratia; 2008;12(4):251-3
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  • [Title] Alveolar soft-part sarcoma of the extremity: a case report.
  • Alveolar soft-part sarcoma (ASPS) is a rare form of soft tissue sarcoma and is most often seen in adolescents and young adults.
  • An 11- year-old boy with ASPS which presented with a markedly vascular tumor in the left thigh, and multiple bilateral pulmonary metastases 8 months after diagnosis is described.
  • The patient has remained disease-free for over 5 years since the initial diagnosis.

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  • (PMID = 19158970.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2580048
  • [Keywords] NOTNLM ; alveolar soft – part sarcoma / children / long term survival / metastases / pulmonary
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88. Mizuno H, Hyakusoku H: Fat grafting to the breast and adipose-derived stem cells: recent scientific consensus and controversy. Aesthet Surg J; 2010 May-Jun;30(3):381-7
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  • However, new guidelines issued by the American Society of Plastic Surgeons in 2009 announced that fat grafting to the breast is not a strongly recommended procedure, as there are limited scientific data on the safety and efficacy of this particular type of fat transfer.
  • Recent progress by several groups has revealed that multipotent adult stem cells are present in human adipose tissue.
  • This cell population, termed adipose-derived stem cells (ADSC), represents a promising approach to future cell-based therapies, such as tissue engineering and regeneration.
  • Although tissue augmentation by fat grafting does have several advantages in that it is a noninvasive procedure and results in minimal scarring, it is essential that such a procedure be supported by evidence-based medicine and that further basic scientific and clinical research is conducted to ensure that fat grafting is a safe and effective procedure.

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  • [CommentIn] Aesthet Surg J. 2010 May-Jun;30(3):387-9 [20601561.001]
  • (PMID = 20601560.001).
  • [ISSN] 1527-330X
  • [Journal-full-title] Aesthetic surgery journal
  • [ISO-abbreviation] Aesthet Surg J
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 59
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89. Raney RB, Chintagumpala M, Anderson J, Pappo A, Qualman S, Wharam M, Wiener E, Meyer W, Soft-Tissue Sarcoma Committee of the Children's Oncology Group, Arcadia, California: Results of treatment of patients with superficial facial rhabdomyosarcomas on protocols of the Intergroup Rhabdomyosarcoma Study Group (IRSG), 1984-1997. Pediatr Blood Cancer; 2008 May;50(5):958-64
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  • RESULTS: Thirty-two patients were males; 35 patients were 1-9 years old at diagnosis.
  • Patients (46/47) had localized disease: 18 biopsy only (Group III), 17 microscopic residual tumor (Group II), and 11 complete resection without residual tumor (Group I).
  • Eight-year EFS rates were 72% for 22 patients with embryonal RMS and 53% for 23 patients with alveolar RMS (P = 0.28).

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
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  • (PMID = 18240175.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U10 CA072989; United States / NCI NIH HHS / CA / U10 CA029511; United States / NCI NIH HHS / CA / U10 CA072989-04; United States / NCI NIH HHS / CA / CA-24507; United States / NCI NIH HHS / CA / CA-72989; None / None / / U10 CA072989-04; United States / NCI NIH HHS / CA / U10 CA024507-26; None / None / / U10 CA024507-26; United States / NCI NIH HHS / CA / U10 CA029511-28; United States / NCI NIH HHS / CA / CA-29511; United States / NCI NIH HHS / CA / U10 CA024507
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS319313; NLM/ PMC3357210
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90. Benetos IS, Mavrogenis AF, Soultanis KCh, Zoubos AB, Papagelopoulos PJ, Soucacos PN: Alveolar soft part sarcoma of the forearm: a case report. J Surg Orthop Adv; 2006;15(4):209-13
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  • [Title] Alveolar soft part sarcoma of the forearm: a case report.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma that most commonly arises in the deep soft tissues of the lower extremities of adults.
  • Median survival of patients with metastatic ASPS has been reported to be from 3 to 3.3 years.
  • In this article, a case of an 11-year-old male with primary ASPS of the right forearm is presented.
  • Three years after diagnosis, the patient developed pulmonary metastases.
  • Chemotherapy was unsuccessfully used to control the metastatic disease.
  • This time to death after the development of metastases vastly exceeded the previously reported survival rates of patients with metastatic ASPS.
  • [MeSH-major] Forearm. Sarcoma, Alveolar Soft Part / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 17313933.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Haeck PC, Hait P: Into the twenty-first century: the history of the American Society of Plastic Surgeons from 1995 to 2006. Plast Reconstr Surg; 2006 Oct;118(5 Suppl):2S-31S
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Into the twenty-first century: the history of the American Society of Plastic Surgeons from 1995 to 2006.
  • [MeSH-major] Societies, Medical / history. Surgery, Plastic

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  • (PMID = 17006313.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
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92. Wakely PE Jr, McDermott JE, Ali SZ: Cytopathology of alveolar soft part sarcoma: a report of 10 cases. Cancer; 2009 Dec 25;117(6):500-7
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  • [Title] Cytopathology of alveolar soft part sarcoma: a report of 10 cases.
  • BACKGROUND: Alveolar soft part sarcoma (ASPS) rarely is subjected to cytopathologic evaluation.
  • The objectives of the current study were to evaluate the cytomorphology of 10 ASPS cases on fine-needle aspiration (FNA) or imprint cytology, review the literature, and highlight potential diagnostic pitfalls.
  • METHODS: The authors searched their files for all lesions that were signed out as ASPS or suspicious for ASPS and searched the surgical pathology files for any cases of ASPS that had corresponding cytology.
  • RESULTS: Ten cases of ASPS were retrieved from 7 patients (male-to-female ratio, 4:3; mean age, 22 years).
  • All had subsequent tissue confirmation.
  • Nine cases were diagnosed correctly as ASPS/consistent with ASPS, and 1 specimen was diagnosed as "tumor, not otherwise specified".
  • CONCLUSIONS: The results of the current study indicated that ASPS has cytomorphology that overlaps with several other neoplasms, including renal cell carcinoma.
  • Nonetheless, the morphologic features, when combined with the clinical presentation, radiologic findings, and ancillary testing, may allow for a specific diagnosis.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Adult. Child. Diagnosis, Differential. Female. Humans. Male

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  • [Copyright] (c) 2009 American Cancer Society.
  • (PMID = 19787801.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Fox BD, Patel A, Suki D, Rao G: Surgical management of metastatic sarcoma to the brain. J Neurosurg; 2009 Jan;110(1):181-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of metastatic sarcoma to the brain.
  • OBJECT: Metastatic sarcoma to the brain is rare and represents a therapeutic challenge due to its relative resistance to radio- and chemotherapy.
  • The authors reviewed a series of patients with metastatic sarcoma to the brain treated surgically to determine outcomes and identify predictors of survival in these patients.
  • METHODS: A retrospective review of prospectively collected data was undertaken on patients undergoing surgery between 1993 and 2005 for metastatic sarcoma to the brain at The University of Texas, M.D.
  • RESULTS: During the study period, 62 patients underwent 84 operations for metastatic sarcoma to the brain.
  • In multivariate and univariate analysis, control of systemic disease, and sarcomas originating from bone, cartilage, or soft tissue were predictors of survival.
  • Patients with control of systemic disease had survival advantage when compared with those who did not.
  • In patients with alveolar soft-part sarcoma, there was a significantly increased survival advantage compared with all other histological subgroups.
  • CONCLUSIONS: The authors' results suggest that in selected patients, resection of metastatic sarcoma to the brain is associated with a relatively low risk of operative death and results in improvement in neurological function.
  • Patients with systemic control of their primary disease and certain histological subtypes (specifically alveolar soft-part sarcoma) have improved overall and progression-free survival.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Neurosurgical Procedures. Sarcoma / secondary. Sarcoma / surgery


94. Nielsen LJ, Olsen LF, Ozalp VC: Aptamers embedded in polyacrylamide nanoparticles: a tool for in vivo metabolite sensing. ACS Nano; 2010 Aug 24;4(8):4361-70
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  • The AptaNPs comprise 30 nm polyacrylamide nanoparticles, prepared by inverse microemulsion polymerization, which contain water-soluble aptamer switch probes (ASPs) trapped in the porous matrix of the nanoparticles.

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  • (PMID = 20731422.001).
  • [ISSN] 1936-086X
  • [Journal-full-title] ACS nano
  • [ISO-abbreviation] ACS Nano
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / Adenine Nucleotides; 0 / Aptamers, Nucleotide; 0 / DNA Probes; 0 / Emulsions; 9003-05-8 / polyacrylamide
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95. Zarrin-Khameh N, Kaye KS: Alveolar soft part sarcoma. Arch Pathol Lab Med; 2007 Mar;131(3):488-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma.
  • This article provides an overview of the pathology of alveolar soft part sarcoma, focused on its morphology, special stains useful in diagnosis, and the clinical and radiographic features of the disease.
  • Alveolar soft part sarcoma is a rare neoplasm of unknown histogenesis with poor prognosis.
  • Although there are several immunohistochemical stains available to help reach the diagnosis, the morphology of the tumor should be considered the main diagnostic feature.
  • The periodic acid-Schiff stain is the best single stain that supports the diagnosis.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Adolescent. Adult. Diagnosis, Differential. Female. Humans. Male. Prognosis

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  • (PMID = 17516754.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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96. Rohrich RJ, McGrath MH, Lawrence TW, ASPS Plastic Surgery Workforce Task Force, AAMC Center for Workforce Studies: Plastic surgeons over 50: practice patterns, satisfaction, and retirement plans. Plast Reconstr Surg; 2008 Apr;121(4):1458-74; discussion 1475-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plastic surgeons over 50: practice patterns, satisfaction, and retirement plans.
  • BACKGROUND: Approximately 56 percent of all currently active plastic surgeons in the United States are older than 50 years and are likely to retire in the next 10 to 20 years.
  • The 2006 Survey of Plastic Surgeons Over the Age of 50 was designed to provide insight regarding the practice patterns, retirement plans, and issues of importance to plastic surgeons older than 50 to provide an indicator of future workforce needs for the specialty.
  • METHODS: The survey was part of a larger study of physicians older than 50 across all specialties conducted by the Association of American Medical Colleges Center for Workforce Studies, in collaboration with the American Society of Plastic Surgeons, the American Medical Association, the Council of Medical Specialty Societies, and seven additional medical specialty associations.
  • Surveys were mailed to 1434 active and retired plastic surgeons aged 50 to 79 years; the response rate was 59.1 percent.
  • RESULTS: Full-time reconstructive plastic surgeons older than 50 spend more hours per week practicing medicine (56.5 hours per week) than cosmetic plastic surgeons (49.7 hours per week) and all physicians (53.7 hours per week).
  • Plastic surgeons retire slightly earlier than other physicians and cite rising malpractice costs, insufficient reimbursement, and increasing competition as important factors when considering retirement.
  • CONCLUSIONS: There are significant differences in the practices, satisfaction, and factors influencing retirement plans for plastic surgeons that focus on cosmetic versus reconstructive surgery.
  • Further study of these two components of plastic surgery may be warranted.
  • [MeSH-major] Job Satisfaction. Practice Patterns, Physicians'. Retirement. Surgery, Plastic

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  • (PMID = 18349669.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Farkas V, Vass E, Hanssens I, Majer Z, Hollósi M: Cyclic peptide models of the Ca2+-binding loop of alpha-lactalbumin. Bioorg Med Chem; 2005 Sep 1;13(17):5310-20
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  • Infrared spectra showed that in the Ca2+ complex of model comprising the binding Asp residues of LA, the cation is coordinated to the COO- groups of all three Asps, while in the complex of model comprising nonbinding Asp residues of LA, the two neighboring Asp side chains form a bridged Ca2+-binding system.

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  • (PMID = 16046135.001).
  • [ISSN] 0968-0896
  • [Journal-full-title] Bioorganic & medicinal chemistry
  • [ISO-abbreviation] Bioorg. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Peptides, Cyclic; 9013-90-5 / Lactalbumin; SY7Q814VUP / Calcium
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98. Parham DM, Qualman SJ, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, Meyer WH, Soft Tissue Sarcoma Committee of the Children's Oncology Group: Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group. Am J Surg Pathol; 2007 Jun;31(6):895-901
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  • [Title] Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group.
  • At the molecular level, alveolar rhabdomyosarcomas (ARMS) are characterized by 3 mutually exclusive PAX/FKHR conditions: PAX3/FKHR fusion (present in 60% of cases), PAX7/FKHR fusion (present in 20%), and PAX/FKHR fusion-negativity (present in 20%).
  • The possibility of morphologic variation among these molecular subtypes has not been investigated.
  • Of these features, only totally solid alveolar architecture reached significance (P=0.00014), with 7 of 16 PAX/FKHR-negative cases lacking this feature, compared with 0 of 36 PAX3/FKHR cases and 2/13 PAX7/FKHR cases.
  • These preliminary results indicate that in general, only totally solid alveolar architecture in ARMS may predict the absence of a PAX/FKHR fusion.
  • No features seemed to predict the presence of a particular fusion type.
  • [MeSH-major] Oncogene Proteins, Fusion / genetics. Rhabdomyosarcoma, Alveolar / genetics. Rhabdomyosarcoma, Alveolar / pathology

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  • (PMID = 17527077.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 98543; United States / NCI NIH HHS / CA / CA24507; United States / NCI NIH HHS / CA / CA72989; United States / NCI NIH HHS / CA / CA81659; United States / NCI NIH HHS / CA / CA89461; United States / NCI NIH HHS / CA / CA98413; United States / NCI NIH HHS / CA / CA98543
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FOXO1 protein, human; 0 / Forkhead Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / PAX3 protein, human; 0 / PAX7 Transcription Factor; 0 / PAX7 protein, human; 0 / Paired Box Transcription Factors
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99. Zibat A, Missiaglia E, Rosenberger A, Pritchard-Jones K, Shipley J, Hahn H, Fulda S: Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma. Oncogene; 2010 Dec 2;29(48):6323-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma.
  • Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and comprises two major histological subtypes: alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS).
  • [MeSH-major] Hedgehog Proteins / physiology. Rhabdomyosarcoma, Alveolar / metabolism. Rhabdomyosarcoma, Embryonal / metabolism. Signal Transduction / physiology
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Gene Fusion. Humans. Infant. Kruppel-Like Transcription Factors / analysis. Male. Myogenic Regulatory Factor 5 / analysis. Nerve Tissue Proteins / analysis. Prognosis. Receptors, Cell Surface / analysis. Transcription Factors / analysis

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  • (PMID = 20818440.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / GLI1 protein, human; 0 / GLI3 protein, human; 0 / Hedgehog Proteins; 0 / Kruppel-Like Transcription Factors; 0 / MYF5 protein, human; 0 / Myogenic Regulatory Factor 5; 0 / Nerve Tissue Proteins; 0 / Receptors, Cell Surface; 0 / Transcription Factors; 0 / patched receptors
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100. Hersh AL, Beekmann SE, Polgreen PM, Zaoutis TE, Newland JG: Antimicrobial stewardship programs in pediatrics. Infect Control Hosp Epidemiol; 2009 Dec;30(12):1211-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To describe the prevalence, characteristics, and barriers to implementation of antimicrobial stewardship programs (ASPs) in pediatrics.
  • RESULTS: Of 246 pediatric infectious disease consultants surveyed, 147 (60%) responded.
  • The percentage of respondents from freestanding children's hospitals who were planning ASPs was higher than the percentage of respondents from other settings who were planning ASPs (P = .04).
  • Many programs were not monitoring important end points associated with ASPs, including cost and number of antibiotic-days.
  • CONCLUSIONS: The prevalence of ASPs in pediatrics is limited, and opportunities exist to improve current programs.

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  • (PMID = 19852666.001).
  • [ISSN] 1559-6834
  • [Journal-full-title] Infection control and hospital epidemiology
  • [ISO-abbreviation] Infect Control Hosp Epidemiol
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / T32HD044331; United States / NCPDCID CDC HHS / CI / U50 CI000358
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents
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