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1. Stockwin LH, Vistica DT, Kenney S, Schrump DS, Butcher DO, Raffeld M, Shoemaker RH: Gene expression profiling of alveolar soft-part sarcoma (ASPS). BMC Cancer; 2009 Jan 15;9:22
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  • [Title] Gene expression profiling of alveolar soft-part sarcoma (ASPS).
  • BACKGROUND: Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft tissue sarcoma affecting predominantly adolescents and young adults.
  • METHODS: For seven patients with confirmed primary or metastatic ASPS, RNA samples were isolated immediately following surgery, reverse transcribed to cDNA and each sample hybridized to duplicate high-density human U133 plus 2.0 microarrays.
  • A subset of the most interesting genes was then validated using quantitative RT-PCR and immunohistochemistry.
  • A number of muscle-restricted transcripts (ITGB1BP3/MIBP, MYF5, MYF6 and TRIM63) were also identified, strengthening the case for a muscle cell progenitor as the origin of disease.
  • CONCLUSION: Results from this first comprehensive study of ASPS gene expression identifies several targets involved in angiogenesis, metastasis and myogenic differentiation.

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  • (PMID = 19146682.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Validation Studies
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2635365
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2. Vistica DT, Hollingshead M, Borgel SD, Kenney S, Stockwin LH, Raffeld M, Schrump DS, Burkett S, Stone G, Butcher DO, Shoemaker RH: Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapy. J Pediatr Hematol Oncol; 2009 Aug;31(8):561-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic vulnerability of an in vivo model of alveolar soft part sarcoma (ASPS) to antiangiogenic therapy.
  • In vivo growth of alveolar soft part sarcoma (ASPS) was achieved using subcutaneous xenografts in sex-matched nonobese diabetic severe combined immunodeficiency mice.
  • One tumor, currently at passage 6, has been maintained in vivo for 32 months and has maintained characteristics consistent with those of the original ASPS tumor including (1) tumor histology and staining with periodic acid Schiff/diastase, (2) the presence of the ASPL-TFE3 type 1 fusion transcript, (3) nuclear staining with antibodies to the ASPL-TFE3 type 1 fusion protein, (4) maintenance of the t(X;17)(p11;q25) translocation characteristic of ASPS, (5) stable expression of signature ASPS gene transcripts and finally, the development and maintenance of a functional vascular network, a hallmark of ASPS.
  • The ASPS xenograft tumor vasculature encompassing nests of ASPS cells is highly reactive to antibodies against the endothelial antigen CD34 and is readily accessible to intravenously administered fluorescein isothiocyanate-dextran.
  • In summary, this study describes a preclinical in vivo model for ASPS which will facilitate investigation into the biology of this slow growing soft tissue sarcoma and demonstrates the feasibility of using an antiangiogenic approach in the treatment of ASPS.

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  • (PMID = 19636271.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / N01CO12400; United States / Intramural NIH HHS / / Z99 CA999999; United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antigens, CD34; 0 / Antineoplastic Agents; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab; 7M7YKX2N15 / Topotecan
  • [Other-IDs] NLM/ NIHMS118018; NLM/ PMC2784654
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3. Aliu O, Chung KC: Readability of ASPS and ASAPS educational web sites: an analysis of consumer impact. Plast Reconstr Surg; 2010 Apr;125(4):1271-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Readability of ASPS and ASAPS educational web sites: an analysis of consumer impact.
  • BACKGROUND: Patients use the Internet to educate themselves about health-related topics, and learning about plastic surgery is a common activity for enthusiastic consumers in the United States.
  • How to educate consumers regarding plastic surgical procedures is a continued concern for plastic surgeons when faced with the growing portion of the American population having relatively low health care literacy.
  • METHODS: The authors studied the readability of patient education materials related to common plastic surgery procedures from the American Society of Plastic Surgeons (ASPS) and the American Society for Aesthetic Plastic Surgery (ASAPS) Web sites and compared them with materials on similar topics from 10 popular health information-providing sites.
  • RESULTS: The authors found that all analyzed documents on the ASPS and ASAPS Web sites targeted to the consumers were rated to be more difficult than the recommended reading grade level for most American adults, and these documents were consistently among the most difficult to read when compared with the other health information Web sites.
  • CONCLUSIONS: The Internet is an increasingly popular avenue for patients to educate themselves about plastic surgery procedures.
  • Patient education material provided on ASPS and ASAPS Web sites should be written at recommended reading grade levels to ensure that it is readable and comprehensible to the targeted audience.

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  • (PMID = 20072085.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / K24 AR053120; None / None / / K24 AR053120-01A2; United States / NIAMS NIH HHS / AR / K24 AR053120-01A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS172906; NLM/ PMC2845740
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4. Lazar AJ, Das P, Tuvin D, Korchin B, Zhu Q, Jin Z, Warneke CL, Zhang PS, Hernandez V, Lopez-Terrada D, Pisters PW, Pollock RE, Lev D: Angiogenesis-promoting gene patterns in alveolar soft part sarcoma. Clin Cancer Res; 2007 Dec 15;13(24):7314-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiogenesis-promoting gene patterns in alveolar soft part sarcoma.
  • PURPOSE: We examined a cohort of patients with alveolar soft part sarcoma (ASPS) treated at our institution and showed the characteristic ASPSCR1-TFE3 fusion transcript in their tumors.
  • EXPERIMENTAL DESIGN: Medical records of 71 patients with ASPS presenting at the University of Texas M.D.
  • RNA extracted from available fresh-frozen and formalin-fixed paraffin-embedded human ASPS tumors were analyzed for ASPSCR1-TFE3 fusion transcript expression using reverse transcription-PCR and by angiogenesis oligomicroarrays with immunohistochemical confirmation.
  • ASPSCR1-TFE3 fusion transcripts were identified in 16 of 18 ASPS samples.
  • In the three frozen samples subjected to an angiogenesis oligoarray, 18 angiogenesis-related genes were up-regulated in tumor over adjacent normal tissue.
  • Immunohistochemistry for jag-1, midkine, and angiogenin in 33 human ASPS samples confirmed these results.
  • Comparison with other sarcomas indicates that the ASPS angiogenic signature is unique.
  • CONCLUSION: ASPS is a highly vascular and metastatic tumor with a surprisingly favorable outcome; therapeutically resistant metastases drive mortality.
  • Future molecular therapies targeting overexpressed angiogenesis-promoting proteins (such as those identified here) could benefit patients with ASPS.
  • [MeSH-major] Neovascularization, Pathologic / genetics. Sarcoma, Alveolar Soft Part / genetics
  • [MeSH-minor] Adult. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Neoplasm Proteins / genetics. Oncogene Proteins, Fusion / genetics. RNA, Messenger / analysis. Reverse Transcriptase Polymerase Chain Reaction. Survival Analysis. Tissue Array Analysis

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  • (PMID = 18094412.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / TFE3 protein, human
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5. Xin FY, Rana N, Ming Z, Lang YB: Alveolar soft part sarcoma of the retro peritoneum. J Cancer Res Ther; 2010 Jan-Mar;6(1):117-9
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  • [Title] Alveolar soft part sarcoma of the retro peritoneum.
  • Alveolar Soft Part Sarcoma (ASPS), also called Alveolar Soft-Tissue Sarcoma, is a rare type of soft-tissue neoplasm with a poor long term prognosis.
  • The pathological diagnosis was ASPS.
  • [MeSH-major] Retroperitoneal Neoplasms / pathology. Sarcoma, Alveolar Soft Part / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 20479565.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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6. Ishikawa M, Ishizuka O, Nakayama T, Kobayashi S, Igawa Y, Nishizawa O, Sugimoto K, Yamashita T, Matsushita T: Alveolar soft-part sarcoma of the retroperitoneum. Int J Urol; 2006 Oct;13(10):1355-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of the retroperitoneum.
  • The pathological diagnosis was alveolar soft-part sarcoma (ASPS).
  • Alveolar soft-part sarcoma is a rare soft-tissue tumor that accounts for approximately 0.5-1% of soft-tissue sarcomas.
  • Herein is reported a case of ASPS of the retroperitoneum with radiological and pathological findings.
  • [MeSH-major] Retroperitoneal Neoplasms / diagnosis. Sarcoma, Alveolar Soft Part / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17010020.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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7. Wu J, Brinker DA, Haas M, Montgomery EA, Argani P: Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy. Int J Surg Pathol; 2005 Jan;13(1):81-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy.
  • Alveolar soft part sarcoma (ASPS) is a rare neoplasm that most commonly presents in the lower extremities.
  • Although ASPS has distinctive histologic features, it may cause diagnostic problems when it arises in unusual locations.
  • To our knowledge, only 1 case of ASPS arising within the breast has previously been reported.
  • Here, we report a second case of primary mammary ASPS.
  • The excision more clearly revealed the lesion's alveolar architecture and demonstrated cells with more eosinophilic cytoplasm, along with the xanthomatous cells.
  • The diagnosis of ASPS was confirmed by electron microscopy, which revealed characteristic membrane-bound rhomboidal crystals, as well as by nuclear labeling for TFE3 protein by immunohistochemistry.
  • With this report, we confirm the utility of a novel immunohistochmical technique for the identification of an ASPS presenting in an unusual locale.
  • [MeSH-major] Breast Neoplasms / pathology. DNA-Binding Proteins. Deoxycytidine / analogs & derivatives. Sarcoma / secondary. Soft Tissue Neoplasms / pathology. Transcription Factors. Xanthomatosis / pathology

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  • (PMID = 15735860.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA88843
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antimetabolites, Antineoplastic; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / CD68 antigen, human; 0 / DNA-Binding Proteins; 0 / TFE3 protein, human; 0 / Transcription Factors; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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8. Guntupalli S, Anderson ML, Bodurka DC: Alveolar soft part sarcoma of the cervix: case report and literature review. Arch Gynecol Obstet; 2009 Feb;279(2):263-5
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the cervix: case report and literature review.
  • Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy typically found in the extremities or chest of young adults.
  • We present a case of an alveolar soft part sarcoma arising in the endocervix of a 38-year-old premenopausal woman.
  • No evidence of metastatic disease was found after extensive surgical staging.
  • Since treatment, she has since remained disease-free for more than 5 years without additional therapy.
  • This is the second case of ASPS arising in the endocervix of which we are aware.
  • Our observations suggest simple hysterectomy suffices for optimal clinical management of cervical ASPS and that surgical staging of this disease offers little prognostic benefit.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Uterine Cervical Neoplasms / diagnosis


9. Selber JC, Nelson JA, Ashana AO, Bergey MR, Bristol MN, Sonnad SS, Serletti JM, Wu LC: Breast cancer screening prior to cosmetic breast surgery: ASPS members' Adherence to American Cancer Society Guidelines. Plast Reconstr Surg; 2009 Nov;124(5):1375-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast cancer screening prior to cosmetic breast surgery: ASPS members' Adherence to American Cancer Society Guidelines.
  • BACKGROUND: The goal of this study was to determine the self-reported breast cancer screening practices of American plastic surgeons and the degree to which those practices adhere to the American Cancer Society guidelines.
  • METHODS: The authors conducted an online survey of the members of the American Society of Plastic Surgeons.
  • Questions assessed practice composition, American Cancer Society guideline familiarity, and preoperative breast cancer screening in patients seeking aesthetic breast surgery.
  • In total, 47 percent appeared to follow the American Cancer Society guidelines, while 64 percent claimed familiarity.
  • Number of years in practice and familiarity with the American Cancer Society guidelines also resulted in more perioperative diagnoses.
  • CONCLUSIONS: Knowledge of the American Cancer Society guidelines is an essential component of effective cancer screening, but only two-thirds of plastic surgeons claim familiarity with them, and fewer than half report concordant practices.
  • As plastic surgeons who often perform surgical procedures on the breast in women with no history of breast disease, we have an obligation to understand and apply consistent, reliable breast cancer screening practices to ensure the well-being of our patients.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / prevention & control. Guideline Adherence / statistics & numerical data. Mammaplasty. Mammography. Mass Screening. Practice Patterns, Physicians' / statistics & numerical data
  • [MeSH-minor] Adult. Aged. American Cancer Society. Confounding Factors (Epidemiology). Early Detection of Cancer. Esthetics. Female. Humans. Internet. Logistic Models. Male. Middle Aged. Odds Ratio. Practice Guidelines as Topic. Sex Factors. Surveys and Questionnaires. Time Factors. United States


10. Gitau GM, Shepherd JH, Hughes G, Oriolowo A, Yiannakis D: Alveolar soft part sarcoma of the uterine cervix. Int J Gynecol Cancer; 2008 Jul-Aug;18(4):853-6
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the uterine cervix.
  • Histology and immunohistochemistry on a wedge biopsy had features consistent with alveolar soft part sarcoma (ASPS).
  • We review literature on diagnosis and treatment of genital ASPS.
  • [MeSH-major] Rhabdomyosarcoma, Alveolar / diagnosis. Uterine Cervical Neoplasms / diagnosis


11. Goldberg J, Demetri GD, Choy E, Rosen L, Pappo A, Dubois S, Geller J, Chai F, Ferrari D, Wagner AJ: Preliminary results from a phase II study of ARQ 197 in patients with microphthalmia transcription factor family (MiT)-associated tumors. J Clin Oncol; 2009 May 20;27(15_suppl):10502

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MiT tumors include clear cell sarcoma (CCS), alveolar soft part sarcoma (ASPS), and translocation-associated renal cell carcinoma (TLA RCC) and are linked biologically by a shared activated transcriptional mechanism which directly upregulates c-Met.
  • Tumors with this type of chromosomal abnormality are generally resistant to all approved therapies and, in the absence of complete surgical resection, prove invariably fatal.
  • RESULTS: To date, 28 pts (19 females, 9 males; median age = 21; 7 CCS, 17 ASPS, 4 RCC) have been treated.
  • One pt with CCS demonstrated a confirmed PR, 15 pts (10 ASPS, 2 CCS, 3 RCC) demonstrated stable disease (SD) for durations up to 29+ weeks, and 4 pts progressed.
  • An overall response rate of 5% and a disease control rate (CR+PR+SD) of 80% were demonstrated among 20 pts who were evaluable for efficacy.

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  • (PMID = 27963690.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Magnan HD, Chou T, LaQuaglia MP, Gerald W, Ladanyi M, Merchant MS: Elevated expression of VEGFR-2 and VEGFA in desmoplastic small round cell tumor (DSRCT) and activity of bevacizumab and irinotecan in a xenograft model of DSRCT. J Clin Oncol; 2009 May 20;27(15_suppl):10016

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: RNA was extracted from frozen tumor samples (DSRCT, alveolar soft part sarcoma, alveolar rhabdomyosarcoma, synovial sarcoma, and Ewing sarcoma) and a human DSRCT cell line, JN-DSRCT.
  • RESULTS: Microarray data demonstrated an average of 4.5 times higher RNA expression of VEGFR-2 (KDR) in DSRCT tumor samples as compared to the other translocation-associated sarcomas (p = 3.6 E-12).
  • VEGFR-2 was highly expressed in the JN-DSRCT line as compared to other sarcoma lines.
  • VEGFA was also highly overexpressed in the DSRCT line and tumor samples when compared to the other translocation-associated sarcomas (2.5 times, p = 1.1E-10).

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  • (PMID = 27962501.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Gardner K, Judson I, Leahy M, Barquin E, Marotti M, Collins B, Young H, Scurr M: Activity of cediranib, a highly potent and selective VEGF signaling inhibitor, in alveolar soft part sarcoma. J Clin Oncol; 2009 May 20;27(15_suppl):10523

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of cediranib, a highly potent and selective VEGF signaling inhibitor, in alveolar soft part sarcoma.
  • : 10523 Background: Alveolar soft part sarcoma (ASPS) is a rare entity making up <1% of soft tissue sarcomas (STS).
  • It is typically indolent but with a high incidence of metastatic disease, usually to lungs, but also to sites such as the brain.
  • This is a preliminary report of the activity of cediranib, a highly potent and selective VEGF signaling inhibitor, in this disease.
  • METHODS: Efficacy and tolerability data were collected for seven patients with ASPS.
  • RESULTS: Median age at diagnosis was 39 years (range: 26-49).
  • All patients had pulmonary metastases and two had additional sites of disease (brain, bone, intra-abdominal) at study entry.
  • Four patients had a best response of partial response, two patients had a confirmed reduction in maximum tumor diameter of ≥10% and <30% and one patient experienced stable disease.
  • CONCLUSIONS: These data demonstrate the promising preliminary activity and safety of chronic administration of cediranib in this disease.
  • Further investigation is warranted, particularly as there is no effective systemic treatment for patients with advanced ASPS.

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  • (PMID = 27963912.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Tapisiz OL, Gungor T, Ustunyurt E, Ozdal B, Bilge U, Mollamahmutoglu L: An unusual case of lingual alveolar soft part sarcoma during pregnancy. Taiwan J Obstet Gynecol; 2008 Jun;47(2):212-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual case of lingual alveolar soft part sarcoma during pregnancy.
  • OBJECTIVE: We report a case of alveolar soft part sarcoma (ASPS) of the tongue that presented in the third trimester of pregnancy.
  • CASE REPORT: An 18-year-old, gravida 1, para 0, woman with ASPS of the tongue in the 31st week of pregnancy was described.
  • Approximately 4 months after her first diagnosis, she was referred to our clinic for the delivery of her baby and additional treatment.
  • CONCLUSION: ASPS of the tongue presenting in pregnancy is an extremely rare combination, and to our knowledge, this is the first reported case in the English literature.
  • The diagnostic and therapeutic management of the pregnant patient with cancer, like ASPS, is especially difficult, because it involves both the mother and fetus.
  • [MeSH-major] Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / therapy. Sarcoma, Alveolar Soft Part / diagnosis. Sarcoma, Alveolar Soft Part / therapy. Tongue Neoplasms / diagnosis. Tongue Neoplasms / therapy

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  • (PMID = 18603509.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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15. Lee GW, Kim TH, Min HJ, Kim HJ, Jung WT, Lee OJ, Ko GH: Unusual gastrointestinal metastases from an alveolar soft part sarcoma. Dig Endosc; 2010 Apr;22(2):137-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual gastrointestinal metastases from an alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a rare subtype of soft tissue sarcoma that occurs predominantly in young patients.
  • The common metastatic sites from an ASPS include the lung, brain and bone.
  • However, metastasis of an ASPS to the gastrointestinal tract is extremely rare.
  • Here, we report a rare case of upper gastrointestinal bleeding and jejunal intussusception due to gastrointestinal metastases from an ASPS.
  • [MeSH-major] Jejunal Neoplasms / secondary. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Endoscopy, Digestive System. Humans. Intussusception / diagnosis. Intussusception / etiology. Intussusception / therapy. Male. Young Adult

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  • (PMID = 20447209.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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16. Lazar AJ, Lahat G, Myers SE, Smith KD, Zou C, Wang WL, Lopez-Terrada D, Lev D: Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray. Histopathology; 2009 Dec;55(6):750-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray.
  • AIMS: The molecular signature of alveolar soft part sarcoma (ASPS) is a specific der(17)t(X;17)(p11.2;q25) translocation, resulting in a chimeric transcription factor (ASPSCR1-TFE3).
  • When this disease is no longer amenable to surgical curative intervention, uniformly efficacious therapies are lacking.
  • The aim of this study was to evaluate the expression of potential molecular therapeutic targets in a cohort of ASPS tumour samples.
  • METHODS AND RESULTS: Immunohistochemical analysis for hepatocyte growth factor, c-Met, phosphorylated c-Met, phosphorylated AKT, phosphorylated MEK, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), p53 and vimentin was performed on an ASPS tissue microarray, yielding complete data from 26 tumours.
  • CONCLUSIONS: There is a crucial need for better anti-ASPS therapies.
  • [MeSH-major] Neoplasm Proteins / metabolism. Sarcoma, Alveolar Soft Part / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Humans. Immunohistochemistry. Tissue Array Analysis


17. Gutowski KA, ASPS Fat Graft Task Force: Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force. Plast Reconstr Surg; 2009 Jul;124(1):272-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force.
  • TASK FORCE STATEMENT: In 2007, the American Society of Plastic Surgeons formed a task force to conduct an assessment regarding the safety and efficacy of autologous fat grafting, specifically to the breast, and to make recommendations for future research.
  • [MeSH-major] Adipose Tissue / transplantation

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  • [CommentIn] Plast Reconstr Surg. 2010 Feb;125(2):758-9; author reply 759 [20124871.001]
  • (PMID = 19346997.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline
  • [Publication-country] United States
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18. Petersson F, Michal M: Minute alveolar soft part sarcoma of the endocervix: the smallest ever published case. Appl Immunohistochem Mol Morphol; 2009 Dec;17(6):553-6
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Minute alveolar soft part sarcoma of the endocervix: the smallest ever published case.
  • Alveolar soft part sarcoma (ASPS) is a distinctive mesenchymal tumor of uncertain histogenesis, which is exceedingly rare in the uterine cervix.
  • We herein report the smallest (1.6 mm) ever published case of ASPS of the endocervix with the characteristic histomorphology and immunohistochemical findings.
  • Because of its seemingly much better prognosis, it is important in routine practice to distinguish ASPS from adenocarcinoma of the cervix.
  • This is facilitated by the awareness that ASPS can occur in this location and if there is doubt about the diagnosis on routinely stained sections, the appropriate immunohistochemical study should be performed.
  • Owing to the small number of published ASPSs in the cervix, the optimal treatment strategy has yet to be determined.

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  • (PMID = 19620840.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / MyoD Protein; 0 / MyoD1 myogenic differentiation protein; 0 / TFE3 protein, human
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19. BaniHani MN, Al Manasra AR: Spontaneous regression in alveolar soft part sarcoma: case report and literature review. World J Surg Oncol; 2009;7:53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous regression in alveolar soft part sarcoma: case report and literature review.
  • BACKGROUND: Sarcomas are a type of malignant tumors that arise from connective tissue.
  • Pathological diagnosis for all lesions was Alveolar soft part sarcoma.
  • CONCLUSION: ASPS is a rare type of sarcomas that affect primarily the lower limbs.
  • [MeSH-major] Neoplasm Regression, Spontaneous. Sarcoma, Alveolar Soft Part / pathology

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  • [Cites] Ann Diagn Pathol. 2003 Oct;7(5):306-9 [14571434.001]
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  • (PMID = 19515237.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2703639
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20. Kasashima S, Minato H, Kobayashi M, Ueda Y, Oda Y, Hashimoto S, Inoue M: Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors. APMIS; 2007 Jul;115(7):861-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors.
  • Alveolar soft part sarcoma (ASPS) is a rare tumor of uncertain histogenesis, mainly localized in the extremities.
  • ASPS originating in the uterine corpus is quite rare; only eight such cases have been reported in the literature.
  • We here present another case of ASPS found in the endometrium in a 50-year-old woman.
  • Metastatic malignant tumor, including ASPS from other organs, was excluded by physical examination and imaging modalities.
  • The tumor showed characteristic histological features of ASPS: alveolar architecture with fibrovascular septa and abundant eosinophilic granular cytoplasm with periodic acid-Schiff-positive crystalline material.
  • Diffuse nuclear immunoreactivity for TFE3, a marker recently reported to be specific for ASPS, further supported the diagnosis of ASPS.
  • [MeSH-major] Endometrial Neoplasms / diagnosis. Neprilysin / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Sarcoma, Alveolar Soft Part / diagnosis

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  • (PMID = 17614855.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / TFE3 protein, human; EC 3.4.24.11 / Neprilysin
  • [Number-of-references] 15
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21. Rekhi B, Kumar R, Menon S, Medhi S, Desai SB: Calvarial metastasis of a renal cell carcinoma, mimicking a primary alveolar soft part sarcoma, in a young girl-a rare case report. Pathol Oncol Res; 2009 Mar;15(1):137-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calvarial metastasis of a renal cell carcinoma, mimicking a primary alveolar soft part sarcoma, in a young girl-a rare case report.
  • We present a rare case of a disseminated RCC in a 15-year-old girl, who primarily presented with an occipital soft tissue mass.
  • Computed tomography (CT) of the head revealed a soft tissue mass in the scalp, eroding the occipital bone and extending intracranially.
  • Biopsy examination showed overlapping features of an alveolar soft part sarcoma (ASPS) and a RCC.
  • Diagnosis of a metastatic RCC was ascertained.
  • The present case represents a rare manifestation of a RCC metastasizing at an unusual location i.e. calvarium in the youngest patient known, so far and masquerading a primary ASPS.
  • It also highlights the value of clinico-patho-radiological correlation, including CD10 as a useful IHC marker in diagnosing a RCC in young patients, especially when histopathological features overlap with ASPS.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Sarcoma, Alveolar Soft Part / radiography. Skull Neoplasms / secondary


22. Eley KA, Afzal T, Shah KA, Watt-Smith SR: Alveolar soft-part sarcoma of the tongue: report of a case and review of the literature. Int J Oral Maxillofac Surg; 2010 Aug;39(8):824-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of the tongue: report of a case and review of the literature.
  • Alveolar soft part sarcoma (ASPS) accounts for less than 1% of all sarcomas.
  • More frequently encountered within the lower limbs, the authors present a 24-year-old male with ASPS presenting as an asymptomatic swelling of the lateral tongue.
  • Histological and immunohistochemical features are diagnostic of ASPS.
  • Whilst rare, head and neck surgeons should be aware of ASPS as a potential cause of slow growing lesions, as early surgical resection is vital in view of the propensity for metastatic spread.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Tongue Neoplasms / pathology

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  • [Copyright] Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20335005.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
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23. Hanzer M, Nebl A, Spendel S, Pilhatsch A, Urban C, Benesch M: Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh. Klin Padiatr; 2010 May;222(3):184-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh.
  • A 14-year-old girl was diagnosed with alveolar soft part sarcoma (ASPS) of the thigh and lung metastases.
  • Since ASPS do not respond to conventional chemotherapy antiangiogenic treatment with peginterferon alfa-2b and thalidomide was started.
  • Immunohistochemical analysis of tumor tissue showed expression of vascular endothelial growth factor receptors (VEGFR) 1, 2, 3, and platelet derived growth factor receptor (PDGFR)-alpha and -beta.
  • [MeSH-major] Angiogenesis Inhibitors / adverse effects. Antineoplastic Agents / adverse effects. Indoles / adverse effects. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Pyrroles / adverse effects. Sarcoma, Alveolar Soft Part / drug therapy. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / drug therapy. Surgical Flaps / blood supply. Surgical Flaps / pathology. Thigh

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  • (PMID = 20514624.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib
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24. Zhong M, De Angelo P, Osborne L, Keane-Tarchichi M, Goldfischer M, Edelmann L, Yang Y, Linehan WM, Merino MJ, Aisner S, Hameed M: Dual-color, break-apart FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of Xp11 translocation renal cell carcinoma and alveolar soft part sarcoma. Am J Surg Pathol; 2010 Jun;34(6):757-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dual-color, break-apart FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of Xp11 translocation renal cell carcinoma and alveolar soft part sarcoma.
  • Both Xp11.2 translocation renal cell carcinoma (RCC) and alveolar soft part sarcoma (ASPS) are characterized by various translocations disrupting chromosome Xp11.2, which result in gene fusions involving the TFE3 transcription factor gene.
  • We developed a dual-color, break-apart fluorescence in situ hybridization (FISH) assay to identify the chromosomal break point in paraffin-embedded tissue.
  • This assay was validated using 4 cases of Xp11.2 RCC [proven by karyotype and/or reverse-transcriptase polymerase chain reaction (RT-PCR)], 2 cases of ASPS (proven by karyotype or RT-PCR), the UOK109 cell line carrying the inv(X) (p11;q12), and several negative controls (both neoplastic and non-neoplastic).
  • This break-apart FISH assay is a relatively quick procedure for detecting Xp11.2 RCC and ASPS translocations and can be applied to archival paraffin-embedded tissue.
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, X / genetics. In Situ Hybridization, Fluorescence / methods. Kidney Neoplasms / genetics. Sarcoma, Alveolar Soft Part / genetics

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  • (PMID = 20421778.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / TFE3 protein, human
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25. Kanhere HA, Pai PS, Neeli SI, Kantharia R, Saoji RR, D'cruz AK: Alveolar soft part sarcoma of the head and neck. Int J Oral Maxillofac Surg; 2005 May;34(3):268-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the head and neck.
  • Alveolar soft part sarcoma (ASPS) of the head and neck region has been a rarely reported entity.
  • A retrospective study of the medical records at our institute, revealed thirty-eight cases of ASPS.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / therapy. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / therapy
  • [MeSH-minor] Adolescent. Adult. Chemotherapy, Adjuvant. Child. Disease-Free Survival. Female. Humans. Male. Neoplasm Invasiveness. Neoplasm Metastasis. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 15741035.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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26. Montgomery JR, Conrad GR, Sinha P, Absher K: FDG PET of alveolar soft part sarcoma. Clin Nucl Med; 2010 Oct;35(10):827-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG PET of alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a very rare, but distinctive type of soft tissue sarcoma, whose name is derived from the pseudoalveolar appearance of its histology.
  • In this report, the FDG PET/CT findings of ASPS are described in a 17-year-old asthmatic female who presented with worsening respiratory symptoms and a pelvic mass.
  • In concordance with other soft tissue sarcomas, PET/CT helped to confirm the anatomic origin of the ASPS, to direct its biopsy, and to assess the distribution of disease.
  • [MeSH-major] Fluorodeoxyglucose F18. Positron-Emission Tomography. Sarcoma, Alveolar Soft Part / radionuclide imaging

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  • (PMID = 20838301.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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27. Altuğ T, Inci E, Güvenç MG, Edizer DT, Dervişoğlu S: Alveolar soft part sarcoma of the larynx. Eur Arch Otorhinolaryngol; 2007 Apr;264(4):445-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the larynx.
  • Alveolar soft part sarcoma (ASPS) is a rare malignancy.
  • In this article, we report a case of ASPS occurring in the larynx, an extremely rare location for this rather unusual tumor.
  • To our knowledge, only three cases of laryngeal ASPS have been previously reported in the English literature.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Disease Progression. Female. Hoarseness / diagnosis. Humans. Laryngectomy / methods. Laryngoscopy. Respiratory Sounds / diagnosis. Tomography, X-Ray Computed

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  • [Cites] AJNR Am J Neuroradiol. 2005 Jun-Jul;26(6):1331-5 [15956492.001]
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  • (PMID = 17063352.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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28. Hoshino M, Ogose A, Kawashima H, Izumi T, Hotta T, Hatano H, Morita T, Otsuka H, Umezu H, Yanoma S, Tsukuda M, Endo N: Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma. Cancer Genet Cytogenet; 2009 Apr 15;190(2):75-80
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a distinct, rare soft tissue tumor with an unknown histogenesis and a tendency for late widespread metastases to lung, bone, and brain.
  • It is now clear that they are caused by a specific unbalanced translocation, der(17)t(X;17)(p11;q25), which results in the formation of an ASPSCR1-TFE3 (alias ASPL-TFE3) fusion gene.
  • The rearrangement results in the expression of chimeric transcripts, which can be identified by means of reverse transcriptase-polymerase chain reaction (RT-PCR).
  • We investigated the histogenesis of ASPS and attempted to detect circulating ASPS tumor cells in peripheral blood.
  • The immunohistochemical and genetic details of four cases and one cell line of ASPS were examined.
  • An immunohistochemical analysis and RT-PCR did not detect myogenic differentiation gene MYOD1.
  • The sensitivity of nested RT-PCR for detection of circulating ASPS cells was assessed by demonstrating that the tumor cell-associated gene translocation could be detected in 50 tumor cells/2 mL of blood.
  • Clinically, it was detectable in a peripheral blood sample (2 mL) of ASPS patient with distant metastases.
  • The findings suggest that ASPS is not of skeletal muscle origin.
  • ASPS tumor cells in the peripheral blood could be monitored by RT-PCR.
  • [MeSH-major] Neoplastic Cells, Circulating. Sarcoma, Alveolar Soft Part / pathology

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  • (PMID = 19380023.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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29. Hillyer S, Vicens JC, Levinson H, Bhayani R, Mesea L, Chaudhry R, Fayans E, Fogler R: Alveolar soft-part sarcoma of the tongue in a 17-month-old. Ear Nose Throat J; 2009 Oct;88(10):E4-9
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  • [Title] Alveolar soft-part sarcoma of the tongue in a 17-month-old.
  • Alveolar soft-part sarcoma (ASPS) is a rare and often fatal tumor.
  • ASPS accounts for 5% of all pediatric soft-tissue sarcomas other than rhabdomyosarcomas.
  • In children, ASPS rarely occurs in the oral cavity, and to the best of our knowledge, only 12 cases of ASPS of the tongue occurring during the first decade of life have been previously reported in the literature.
  • Because of the rarity of lingual ASPS in children, no specific treatment protocols have been developed, which makes its management difficult.
  • We report a new case of lingual ASPS in a young child.
  • Postoperatively, she has remained disease-free during 4 years of follow-up.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Infant. Magnetic Resonance Imaging. Neoplasm Staging. Neoplasm, Residual / diagnosis. Neoplasm, Residual / pathology. Neoplasm, Residual / surgery. Radionuclide Imaging. Sodium Pertechnetate Tc 99m. Tomography, X-Ray Computed. Tongue / pathology. Tongue / surgery

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  • (PMID = 19826991.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] A0730CX801 / Sodium Pertechnetate Tc 99m
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30. Rocha LA, Rizo VH, Romañach MJ, de Almeida OP, Vargas PA: Oral metastasis of alveolar soft-part sarcoma: a case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Apr;109(4):587-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral metastasis of alveolar soft-part sarcoma: a case report and review of literature.
  • Alveolar soft-part sarcoma (ASPS) is a rare malignant neoplasm with uncertain histogenesis and with a distinctive morphology.
  • It has been described in the oral cavity, but this is the first report of ASPS metastasizing to the maxillary tuber region.
  • A 27-year-old male patient, who was under chemotherapy treatment for ASPS of the thigh, presented in our dental clinic with a painless and pedunculated nodule on the right tuber maxillae.
  • An incisional biopsy was performed and the diagnosis of metastatic ASPS was made.
  • Unfortunately, the patient died 2 months after the diagnosis of the oral metastasis.
  • Metastases of ASPS to the mouth are very rare and indicate a poor prognosis.
  • [MeSH-major] Gingival Neoplasms / secondary. Maxilla / pathology. Sarcoma, Alveolar Soft Part / secondary
  • [MeSH-minor] Adult. Brain Neoplasms / secondary. Cell Nucleolus / ultrastructure. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Diagnosis, Differential. Fatal Outcome. Gingival Diseases / diagnosis. Granuloma, Giant Cell / diagnosis. Granuloma, Pyogenic / diagnosis. Humans. Male. Muscle Neoplasms / pathology. Thigh / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20303057.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Folpe AL, Deyrup AT: Alveolar soft-part sarcoma: a review and update. J Clin Pathol; 2006 Nov;59(11):1127-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma: a review and update.
  • Alveolar soft-part sarcoma (ASPS) is a rare, distinctive sarcoma, typically occurring in young patients.
  • Recently, our understanding of the genetic events underlying the pathogenesis of ASPS has greatly increased.
  • The historical, histopathological, ultrastructural, immunohistochemical and genetic aspects of ASPS are reviewed in this article.
  • [MeSH-major] Sarcoma, Alveolar Soft Part
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Translocation, Genetic

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  • (PMID = 17071801.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 63
  • [Other-IDs] NLM/ PMC1860509
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32. Roma AA, Yang B, Senior ME, Goldblum JR: TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report. Int J Gynecol Pathol; 2005 Apr;24(2):131-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report.
  • SUMMARY: : Alveolar soft part sarcoma (ASPS) is an uncommon neoplasm that has only rarely been reported in the female genital tract.
  • We report a case of incidentally discovered ASPS in the uterine cervix of a 39-year-old woman that exhibited immunoreactivity for TFE3, a recently described marker of ASPS.
  • Strong nuclear immunoreactivity for TFE3 in tumors characterized by a chromosomal translocation involving the TFE3 gene has been reported in ASPS and a subset of pediatric renal cell carcinomas.
  • To the best of our knowledge, this is the first report of ASPS of the female genital tract with immunoreactivity for TFE3.
  • [MeSH-major] Biomarkers, Tumor / analysis. DNA-Binding Proteins / metabolism. Sarcoma, Alveolar Soft Part / pathology. Transcription Factors / metabolism. Uterine Neoplasms / pathology

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  • (PMID = 15782069.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / DNA-Binding Proteins; 0 / TFE3 protein, human; 0 / Transcription Factors
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33. Chen YD, Hsieh MS, Yao MS, Lin YH, Chan WP: MRI of alveolar soft-part sarcoma. Comput Med Imaging Graph; 2006 Dec;30(8):479-82
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI of alveolar soft-part sarcoma.
  • Alveolar soft-part sarcoma (ASPS) is rare.
  • We present a case of a 30-year-old woman with a 6-month history of a palpable mass in her left thigh.
  • Histologic findings were compatible with ASPS.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17056231.001).
  • [ISSN] 0895-6111
  • [Journal-full-title] Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
  • [ISO-abbreviation] Comput Med Imaging Graph
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Marchac A, Picard A, Landman-Parker J, Larroquet M, Vazquez MP, Franchi G: [A pediatric case of Alveolar Soft Part Sarcoma]. Rev Stomatol Chir Maxillofac; 2007 Dec;108(6):547-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A pediatric case of Alveolar Soft Part Sarcoma].
  • [Transliterated title] Sarcome alvéolaire de la langue: un cas pédiatrique.
  • INTRODUCTION: Alveolar Soft Part Sarcoma (ASPS) is a rare malignant tumor arising from skeletal muscles and occurring usually in young adults.
  • At time of diagnosis the disease is usually advanced and lung metastasis are present in 65% of the cases.
  • The translocation (X; 17), producing an ASPL-TFE3 transcript fusion which is detected on tumoral cells wall, is specific of ASPS.
  • CLINICAL REPORT: We report the case of a child with an ASPS of the tongue and lung metastasis.
  • Firstly this type of sarcoma is very exceptional in a 2-year-old child.
  • Secondly ASPS is not usually susceptible to chemotherapy.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Tongue Neoplasms / diagnosis

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  • (PMID = 17964622.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. Park YJ, Huh SJ, Han J, Kim B, Lee JW, Bae DS: A case of alveolar soft part sarcoma with vaginal metastasis: successful control of vaginal bleeding with external beam irradiation. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1166-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of alveolar soft part sarcoma with vaginal metastasis: successful control of vaginal bleeding with external beam irradiation.
  • Alveolar soft part sarcoma (ASPS) of the vagina is an exceptionally rare neoplasm.
  • Furthermore, vaginal metastasis of ASPS has not been reported.
  • A 28-year-old woman with a history of a right thigh mass diagnosed as ASPS excised 8 years ago presented to the emergency room with massive vaginal bleeding and anemia.
  • Biopsy of a vaginal mass revealed that the tumor was a vaginal metastasis of ASPS.
  • This is the first case of vaginal metastasis of ASPS reported in the literature that was manifested by intractable vaginal bleeding, which was controlled successfully with radiation therapy.
  • [MeSH-major] Hemorrhage / radiotherapy. Lung Neoplasms / therapy. Sarcoma / therapy. Vaginal Neoplasms / radiotherapy


36. Kusafuka K, Muramatsu K, Yabuzaki T, Ishiki H, Asano R, Kamijo T, Iida Y, Ebihara M, Onitsuka T, Kameya T: Alveolar soft part sarcoma of the larynx: a case report of an unusual location with immunohistochemical and ultrastructural analyses. Head Neck; 2008 Sep;30(9):1257-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the larynx: a case report of an unusual location with immunohistochemical and ultrastructural analyses.
  • BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare mesenchymal neoplasm of uncertain origin.
  • In this article, we report a case of ASPS occurring in the larynx, an extremely rare location for this rather unusual tumor.
  • The tumor showed a proliferation of large polygonal cells with periodic-acid-Schiff-positive diastase-resistant intracytoplasmic granules, arranged in an alveolar growth pattern.
  • This case was finally diagnosed as ASPS of the larynx.
  • CONCLUSION: We discuss the histogenesis and differential diagnosis of ASPS with immunohistochemical and ultrastructural findings.
  • TFE3 immunohistochemistry was found to be a very useful marker for the diagnosis of ASPS.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Laryngoscopy / methods. Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Adult. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / analysis. Biopsy, Needle. Disease Progression. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neoplasm Staging. Rare Diseases. Risk Assessment. Treatment Outcome

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  • (PMID = 18286485.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / TFE3 protein, human
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37. Benetos IS, Mavrogenis AF, Soultanis KCh, Zoubos AB, Papagelopoulos PJ, Soucacos PN: Alveolar soft part sarcoma of the forearm: a case report. J Surg Orthop Adv; 2006;15(4):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the forearm: a case report.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma that most commonly arises in the deep soft tissues of the lower extremities of adults.
  • Median survival of patients with metastatic ASPS has been reported to be from 3 to 3.3 years.
  • In this article, a case of an 11-year-old male with primary ASPS of the right forearm is presented.
  • Three years after diagnosis, the patient developed pulmonary metastases.
  • Chemotherapy was unsuccessfully used to control the metastatic disease.
  • This time to death after the development of metastases vastly exceeded the previously reported survival rates of patients with metastatic ASPS.
  • [MeSH-major] Forearm. Sarcoma, Alveolar Soft Part / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 17313933.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Zhu FP, Lu GM, Zhang LJ, Wang JD, An XJ, Dong YC: Primary alveolar soft part sarcoma of vertebra: a case report and literature review. Skeletal Radiol; 2009 Aug;38(8):825-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary alveolar soft part sarcoma of vertebra: a case report and literature review.
  • Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor, which rarely occurs in bone.
  • We present a case of ASPS in a 23-year-old man with a 2-month history of back pain.
  • Computed tomography scanning and magnetic resonance images demonstrated a destructive process in the 12th thoracic vertebra associated with a unilateral soft tissue mass.
  • The tumor showed evidence of hypervascularity on MRI; it obviously was enhanced on T1-weighted images after injection of Gd-GDPA, and signal voids were shown on all pulse sequences which may help to differentiate ASPS from other tumors of the vertebra.
  • We believe that this is the first case of ASPS arising in a vertebra.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Magnetic Resonance Imaging / methods. Spinal Neoplasms / diagnosis. Thoracic Vertebrae / diagnostic imaging. Thoracic Vertebrae / pathology. Tomography, X-Ray Computed / methods

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  • (PMID = 19347336.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
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39. Lai YC, Chiou HJ, Wu HT, Chou YH, Wang HK, Chen PC: Ultrasonographic and MR findings of alveolar soft part sarcoma. J Chin Med Assoc; 2009 Jun;72(6):336-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasonographic and MR findings of alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma, commonly occurring in children and adolescents.
  • We present a 19-year-old female with ASPS in her right lower leg.
  • In a mass with hypervascularity and very low RI on sonography and hypervascularity with flow voids on magnetic resonance imaging, ASPS should be considered.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Thigh

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  • (PMID = 19541571.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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40. Vistica DT, Krosky PM, Kenney S, Raffeld M, Shoemaker RH: Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma. J Pediatr Hematol Oncol; 2008 Jan;30(1):46-52
eagle-i research resources. PMID 18176180 (Special Collections) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS), a rare soft tissue sarcoma, is characterized by a chromosomal translocation der(17)t(X;17)(p11;q25) resulting in the production of 2 fusion proteins encoded by regions of the genes for alveolar soft part locus (ASPL) and the transcription factor E3 (TFE3).
  • Immunohistochemical staining of formalin-fixed, paraffin-embedded ASPS tumors with the fusion-specific antibodies resulted in intense nuclear staining and differentiation between tumors that express the type 1 protein and tumors that express the type 2 protein.
  • These antibodies will be useful for the differential diagnosis of type 1 and type 2 ASPS and also in the detection of the fusion proteins in biochemical and cell biologic investigations.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism. Cell Nucleus / metabolism. Neoplasm Proteins / metabolism. Oncogene Proteins, Fusion / metabolism. Rare Diseases / metabolism. Sarcoma / metabolism
  • [MeSH-minor] Adolescent. Antibodies / chemistry. Antibodies / immunology. Child. Child, Preschool. Diagnosis, Differential. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunohistochemistry. Male. Recombinant Proteins / chemistry. Recombinant Proteins / genetics. Recombinant Proteins / immunology. Translocation, Genetic / immunology

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  • (PMID = 18176180.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Antibodies; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / Recombinant Proteins; 0 / TFE3 protein, human
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41. Wakely PE Jr, McDermott JE, Ali SZ: Cytopathology of alveolar soft part sarcoma: a report of 10 cases. Cancer; 2009 Dec 25;117(6):500-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytopathology of alveolar soft part sarcoma: a report of 10 cases.
  • BACKGROUND: Alveolar soft part sarcoma (ASPS) rarely is subjected to cytopathologic evaluation.
  • The objectives of the current study were to evaluate the cytomorphology of 10 ASPS cases on fine-needle aspiration (FNA) or imprint cytology, review the literature, and highlight potential diagnostic pitfalls.
  • METHODS: The authors searched their files for all lesions that were signed out as ASPS or suspicious for ASPS and searched the surgical pathology files for any cases of ASPS that had corresponding cytology.
  • RESULTS: Ten cases of ASPS were retrieved from 7 patients (male-to-female ratio, 4:3; mean age, 22 years).
  • All had subsequent tissue confirmation.
  • Nine cases were diagnosed correctly as ASPS/consistent with ASPS, and 1 specimen was diagnosed as "tumor, not otherwise specified".
  • CONCLUSIONS: The results of the current study indicated that ASPS has cytomorphology that overlaps with several other neoplasms, including renal cell carcinoma.
  • Nonetheless, the morphologic features, when combined with the clinical presentation, radiologic findings, and ancillary testing, may allow for a specific diagnosis.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology
  • [MeSH-minor] Adult. Child. Diagnosis, Differential. Female. Humans. Male

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  • [Copyright] (c) 2009 American Cancer Society.
  • (PMID = 19787801.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Jun HJ, Lee J, Lim DH, Park JO, Ahn G, Seo SW, Sung KS, Lim DH, Yoo KH, Choi YL: Expression of MET in alveolar soft part sarcoma. Med Oncol; 2010 Jun;27(2):459-65
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of MET in alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma which is characterized by the presence of a specific chromosomal translocation encoding the chimeric transcription factor (ASPL-TFE3) that activates expression of MET.
  • We reviewed the clinical features and treatment outcome of 12 ASPS patients.
  • The high expression of MET in ASPL-TFE3 (+) ASPS may further support the potential role of targeted agents against MET in this rare, chemoresistant tumor.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Proto-Oncogene Proteins c-met / biosynthesis. Receptors, Growth Factor / biosynthesis. Sarcoma, Alveolar Soft Part / pathology

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  • (PMID = 19472090.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Growth Factor; EC 2.7.10.1 / MET protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
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43. Sidi V, Fragandrea I, Hatzipantelis E, Kyriakopoulos C, Papanikolaou A, Bandouraki M, Koliouskas DE: Alveolar soft-part sarcoma of the extremity: a case report. Hippokratia; 2008;12(4):251-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of the extremity: a case report.
  • Alveolar soft-part sarcoma (ASPS) is a rare form of soft tissue sarcoma and is most often seen in adolescents and young adults.
  • An 11- year-old boy with ASPS which presented with a markedly vascular tumor in the left thigh, and multiple bilateral pulmonary metastases 8 months after diagnosis is described.
  • The patient has remained disease-free for over 5 years since the initial diagnosis.

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  • [Cites] Cancer. 1989 Jan 1;63(1):1-13 [2642727.001]
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  • (PMID = 19158970.001).
  • [ISSN] 1790-8019
  • [Journal-full-title] Hippokratia
  • [ISO-abbreviation] Hippokratia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Other-IDs] NLM/ PMC2580048
  • [Keywords] NOTNLM ; alveolar soft – part sarcoma / children / long term survival / metastases / pulmonary
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44. Bu X, Bernstein L: A proposed explanation for female predominance in alveolar soft part sarcoma. Noninactivation of X; autosome translocation fusion gene? Cancer; 2005 Mar 15;103(6):1245-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A proposed explanation for female predominance in alveolar soft part sarcoma. Noninactivation of X; autosome translocation fusion gene?
  • BACKGROUND: Alveolar soft-part sarcoma (ASPS) is a rare malignant soft tissue tumor with both clinically and morphologically distinct features.
  • Recently, ASPS was found to have a nonreciprocal der(17)t(X;17) translocation with the corresponding fusion gene located in chromosome 17.
  • Because females have an extra X-chromosome, their likelihood of developing an X;autosome translocation is theoretically double that of males, and thus, this extra X-chromosome is a likely explanation for female predominance of ASPS.
  • METHODS: The authors used data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry program, which included 87 ASPS cases (33 males and 54 females), and published ASPS cases, which included 317 cases (121 males and 196 females), to test our hypothesis.
  • CONCLUSIONS: Therefore, the authors found a statistical association between the female predominance observed in ASPS and female possession of an extra X-chromosome/noninactivation of the ASPS X;autosome translocation fusion gene.
  • [MeSH-major] Chromosomes, Human, Pair 17. Sarcoma, Alveolar Soft Part / epidemiology. Sarcoma, Alveolar Soft Part / genetics. Soft Tissue Neoplasms / epidemiology. Soft Tissue Neoplasms / genetics. Translocation, Genetic
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. California / epidemiology. Child. Child, Preschool. Female. Genetic Predisposition to Disease. Humans. Incidence. Infant. Male. Middle Aged. Probability. Prognosis. Registries. Retrospective Studies. Risk Assessment. SEER Program. Sex Factors. Survival Analysis

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  • (PMID = 15693033.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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45. Kim YD, Lee CH, Lee MK, Jeong YJ, Kim JY, Park DY, Sol MY: Primary alveolar soft part sarcoma of the lung. J Korean Med Sci; 2007 Apr;22(2):369-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary alveolar soft part sarcoma of the lung.
  • Alveolar soft part sarcoma (ASPS) is a rare epithelial-like soft tissue sarcoma.
  • Primary pulmonary involvement of this sarcoma, without evidence of soft tissue tumor elsewhere, is very exceptional.
  • We present a case of primary ASPS of the lung in a 42-yr-old woman.
  • Histologically, the tumor consisted of alveolar nests of large polygonal tumor cells, the cytoplasm of which frequently revealed periodic acid-Schiff-positive, diastase-resistant intracytoplasmic rod-like structures.
  • [MeSH-major] Lung Neoplasms / pathology. Lung Neoplasms / radiography. Pulmonary Alveoli / pathology. Pulmonary Alveoli / radiography. Sarcoma / pathology. Sarcoma / radiography
  • [MeSH-minor] Adult. Female. Humans. Rare Diseases / pathology. Rare Diseases / radiography. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / radiography

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  • [Cites] Oncology. 2000 May;58(4):319-23 [10838498.001]
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  • (PMID = 17449953.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2693611
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46. Akiyama Y, Baba T, Ibayashi Y, Asai Y, Houkin K: Alveolar soft part sarcoma in brain with cardiac metastasis: a case report. Int J Cardiol; 2007 Jan 18;114(3):e93-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma in brain with cardiac metastasis: a case report.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm.
  • The coexistence of ASPS with cardiac metastasis is quite rare, in particular.
  • In general, the sarcoma is a malignant disease and grows very fast.
  • However, the mean survival time of patients with ASPS is relatively long.
  • Patients who are diagnosed with localized disease usually have a favorable prognosis, while those who present with widespread metastases usually have a poor prognosis and ultimately, succumb to their disease.
  • Because of the long-term period with symptomatic brain tumors in this disease, the patients should be treated even in the presence of multiple metastases in other organs.
  • [MeSH-major] Brain Neoplasms / secondary. Heart Neoplasms / secondary. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Intestinal Neoplasms / secondary. Intestinal Neoplasms / surgery. Lung Neoplasms / secondary. Lung Neoplasms / surgery. Male. Radiosurgery. Thigh

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  • (PMID = 17055085.001).
  • [ISSN] 1874-1754
  • [Journal-full-title] International journal of cardiology
  • [ISO-abbreviation] Int. J. Cardiol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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47. Amin MB, Patel RM, Oliveira P, Cabrera R, Carneiro V, Preto M, Balzer B, Folpe AL: Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence: a unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3. Am J Surg Pathol; 2006 Oct;30(10):1322-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence: a unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3.
  • Alveolar soft-part sarcoma (ASPS) is a rare, clinically, morphologically, ultrastructurally, and cytogenetically distinctive malignant mesenchymal tumor that most classically occurs in the extremities of adolescents and young adults, but has also been described in a number of unusual sites.
  • The molecular signature of ASPS is a specific der(17)t(X;17)(p11.2;q25) translocation, which results in the fusion of TFE3 transcription factor gene (from Xp11) with ASPL at 17q25.
  • Herein, we report a unique case of ASPS presenting in the bladder with subsequent urethral recurrence in a 25-year-old woman.
  • We emphasize the differential diagnoses engendered by ASPS including common, not-so-common, and rare tumors involving the urinary bladder that have a nested architecture, and both clear and eosinophilic cytoplasm, and demonstrate the utility of a broad immunohistochemistry panel including TFE3 for diagnosis.
  • [MeSH-major] Neoplasm Recurrence, Local. Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Urethra / pathology. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / analysis. Biomarkers, Tumor / analysis. Diagnosis, Differential. Disease-Free Survival. Female. Humans. Immunohistochemistry. Ultrasonography

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  • (PMID = 17001165.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / TFE3 protein, human
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48. Almansori M, Turner AR, Girgis S, Vethanayagam D: Alveolar soft-part sarcoma presenting with eosinophilia and shunt. Can Respir J; 2005 Oct;12(7):389-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma presenting with eosinophilia and shunt.
  • Alveolar soft-part sarcoma (ASPS) is a rare soft tissue tumour found in young adults that usually arises in skeletal muscle and occurs most frequently in the lower limbs.
  • Radiological and pathological findings of ASPS in a 34-year-old man who presented with increasing shortness of breath over a period of four to six weeks with peripheral blood eosinophilia, hypoxemia and a significant arteriovenous shunt are reported.
  • The present article is the fourth report of eosinophilia in association with sarcoma, and the first involving ASPS.
  • [MeSH-major] Eosinophilia / complications. Pulmonary Circulation. Sarcoma, Alveolar Soft Part / complications. Soft Tissue Neoplasms / complications

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  • (PMID = 16307030.001).
  • [ISSN] 1198-2241
  • [Journal-full-title] Canadian respiratory journal
  • [ISO-abbreviation] Can. Respir. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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49. Van Buren R, Stewart J 3rd: Alveolar soft part sarcoma presenting as a breast mass in a 13-year-old female. Diagn Cytopathol; 2009 Feb;37(2):122-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma presenting as a breast mass in a 13-year-old female.
  • We report a clinically unsuspected case of alveolar soft part sarcoma (ASPS) presenting in the breast of a 13-year-old female.
  • ASPS is a rare neoplasm that is usually present in the head, neck, or lower extremities.
  • This rare case presentation gives us the opportunity to review the differential diagnosis of adolescent breast lesions.
  • We also will review diagnostic features of ASPS on fine-needle aspiration.
  • These are relatively rare disease processes about which many cytopathology professionals may be unfamiliar.
  • [MeSH-major] Breast Neoplasms / diagnosis. Sarcoma, Alveolar Soft Part / diagnosis
  • [MeSH-minor] Adolescent. Biopsy, Fine-Needle. Breast / pathology. Breast Diseases / diagnosis. Breast Diseases / pathology. Diagnosis, Differential. Female. Humans

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  • (PMID = 19021216.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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50. Genin O, Rechavi G, Nagler A, Ben-Itzhak O, Nazemi KJ, Pines M: Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment? Neoplasia; 2008 Sep;10(9):940-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment?
  • Alveolar soft-part sarcoma (ASPS) is a rare neoplasm with chromosomal translocation that results in ASPL-TFE3 fusion.
  • We demonstrated that the ASPS metastases include also stromal myofibroblasts.
  • The pulmonary ASPS myofibroblasts synthesize serum response factor (SRF), a repressor of Smad3-mediated TGFbeta signaling essential for myofibroblast differentiation and Smad3.
  • These results suggest that the myofibroblasts may serve as a novel target for treatment of ASPS metastases.
  • [MeSH-major] Brain Neoplasms / secondary. Lung Neoplasms / secondary. Muscle Neoplasms / pathology. Sarcoma, Alveolar Soft Part / genetics. Smad3 Protein / metabolism

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  • (PMID = 18714394.001).
  • [ISSN] 1476-5586
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Oncogene Proteins, Fusion; 0 / SMAD3 protein, human; 0 / Serum Response Factor; 0 / Smad3 Protein; 0 / cytoglobin; 9004-22-2 / Globins; EC 1.14.11.2 / Procollagen-Proline Dioxygenase
  • [Other-IDs] NLM/ PMC2517638
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51. Kacerovska D, Michal M, Nemcova J, Vanecek T, Kreuzberg B, Mrazkova P, Koudela K Jr, Kazakov DV: Crystal-deficient alveolar soft-part sarcoma with cutaneous involvement: a case report. Am J Dermatopathol; 2009 May;31(3):272-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Crystal-deficient alveolar soft-part sarcoma with cutaneous involvement: a case report.
  • Alveolar soft-part sarcoma (ASPS) is a rare distinctive sarcoma, in most cases involving deep soft tissues of the extremities.
  • It is associated with a specific unbalanced translocation, der(17)t(X;17)(p11;q25) that results in the formation of an ASPL-TFE3 fusion gene.
  • Microscopically, it is typified by an alveolar growth of large cells containing typical periodic acid-Schiff-positive rod-shaped crystals, often serving as a diagnostic clue.
  • Other distinctive features include nuclear immunoreactivity for transcription factor 3 (TFE3) protein and a typical ultrastructural finding of large crystals with a rectangular or rhomboid shape.
  • The authors present an unusual case of ASPS with cutaneous involvement, which did not exhibit typical large crystals; there were striking round granules.
  • To the best of our knowledge, cutaneous involvement of a crystal-deficient ASPS has not been reported.
  • [MeSH-major] Cytoplasmic Granules / pathology. Sarcoma, Alveolar Soft Part / pathology. Skin / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19384069.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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52. Huang HY, Lui MY, Ladanyi M: Nonrandom cell-cycle timing of a somatic chromosomal translocation: The t(X;17) of alveolar soft-part sarcoma occurs in G2. Genes Chromosomes Cancer; 2005 Oct;44(2):170-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonrandom cell-cycle timing of a somatic chromosomal translocation: The t(X;17) of alveolar soft-part sarcoma occurs in G2.
  • Alveolar soft-part sarcoma (ASPS) is a rare malignant soft-tissue tumor of uncertain lineage that provides an opportunity to address this question.
  • The great majority of ASPSs have relatively simple near-diploid karyotypes characterized by an unbalanced der(17)t(X;17)(p11.2;q25), resulting in nonreciprocal fusion of TFE3 with ASPSCR1 (a.k.a.
  • The presence of a normal X along with the der(17)t(X;17) in ASPSs that occur in men has been well described in previous cytogenetic reports and is most readily explained by a translocation in the G2 phase of the cell cycle.
  • To establish whether formation in G2 is a general feature of the t(X;17), we examined polymorphic loci in Xp11.2-->qter in ASPS from 9 women, including 7 with an unbalanced t(X;17).
  • Given that the two derivative chromosomes of a translocation in G2 would be expected to segregate together half the time, the predominance of an unbalanced der(17)t(X;17) also raises the possibility of a selective advantage in ASPS cells for gain of Xp11.2-->pter or loss of 17q25.3-->qter or retention of an active copy of TFE3.
  • [MeSH-major] Chromosomes, Human, Pair 17. Chromosomes, Human, X. G2 Phase. Sarcoma / genetics. Translocation, Genetic

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  • (PMID = 15952162.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA95785
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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53. Kim HS, Lee HK, Weon YC, Kim HJ: Alveolar soft-part sarcoma of the head and neck: clinical and imaging features in five cases. AJNR Am J Neuroradiol; 2005 Jun-Jul;26(6):1331-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft-part sarcoma of the head and neck: clinical and imaging features in five cases.
  • BACKGROUND AND PURPOSE: Alveolar soft-part sarcoma (ASPS) of the head and neck is an extremely rare malignancy.
  • The purpose of this study was to describe the clinical and imaging features of ASPS of the head and neck.
  • METHODS: Between January 1990 and May 2004 at our institution, five head and neck ASPS were diagnosed in five patients (two male and three female patients; age range, 4-22 years).
  • CONCLUSION: ASPS should be included in the differential diagnosis of head and neck tumor when a slow-growing, large mass with high signal intensity and flow voids on T2-weighted images and strong enhancement on contrast-enhanced CT or MR image is seen, particularly in young female patients.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Magnetic Resonance Imaging. Sarcoma, Alveolar Soft Part / diagnosis. Tomography, X-Ray Computed


54. Bodi I, Gonzalez D, Epaliyange P, Gullan R, Fisher C: Meningeal alveolar soft part sarcoma confirmed by characteristic ASPCR1-TFE3 fusion. Neuropathology; 2009 Aug;29(4):460-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meningeal alveolar soft part sarcoma confirmed by characteristic ASPCR1-TFE3 fusion.
  • Sarcoma metastatic to the brain is uncommon and rarely occurs as the initial manifestation of tumor.
  • Alveolar soft part sarcoma (ASPS) is a rare but well-studied subtype of sarcoma.
  • The histological features were strongly suggestive of ASPS.
  • At the molecular level RT-PCR and sequencing analysis demonstrated ASPCR1-TFE3 fusion confirming the histological diagnosis of ASPS.
  • ASPS typically arise from the soft tissues of the extremities and develop multiple metastatic deposits usually with a long clinical course.
  • This case may represent primary meningeal ASPS although metastatic deposit from an undiscovered primary site cannot be entirely excluded.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Biomarkers, Tumor / genetics. Gene Fusion / genetics. Meningeal Neoplasms / genetics. Sarcoma, Alveolar Soft Part / genetics

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  • (PMID = 18713311.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / TFE3 protein, human
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55. Khanna P, Paidas CN, Gilbert-Barness E: Alveolar soft part sarcoma: clinical, histopathological, molecular, and ultrastructural aspects. Fetal Pediatr Pathol; 2008;27(1):31-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma: clinical, histopathological, molecular, and ultrastructural aspects.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor occurring mainly in the adolescents and young adults.
  • The histopathological, ultrastructural, immunohistochemical, and genetic aspects of ASPS are discussed.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18568987.001).
  • [ISSN] 1551-3823
  • [Journal-full-title] Fetal and pediatric pathology
  • [ISO-abbreviation] Fetal Pediatr Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / S100 Proteins; 0 / Synaptophysin
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56. Moyano S, Aguilera P, Petit A, de Alava E, Mascaró JM, Palou J, Ferrando J, Alos L: Alveolar soft part sarcoma presenting with cutaneous metastases: report of a case with immunohistochemical and molecular characterization. J Am Acad Dermatol; 2009 Jul;61(1):117-20
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma presenting with cutaneous metastases: report of a case with immunohistochemical and molecular characterization.
  • Alveolar soft part sarcoma (ASPS) is an uncommon neoplasm of uncertain histogenesis that usually behaves as a painless, slow-growing mass that metastasizes early.
  • We report a 21-year-old woman with cutaneous metastases of ASPS, whose histologic characteristics gave rise to a wide range of differential diagnoses of both primary and metastatic cutaneous neoplasms.
  • The molecular study identified a type 2 alveolar soft part locus-transcription factor E3 (ASPL-TFE3) fusion, secondary to der(17)t(X;17)(p11.2;q25) translocation.
  • A computed tomography scan performed after the diagnosis was made disclosed a 13-cm primary tumor in the left buttock.
  • Cutaneous metastases presenting as the first sign of ASPS have not been reported previously.
  • We emphasize the difficulties in making the diagnosis of ASPS when it presents in an unusual manner.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / secondary. Skin Neoplasms / secondary

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  • (PMID = 19539846.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Rodríguez-Velasco A, Fermán-Cano F, Cerecedo-Díaz F: Rare tumor of the tongue in a child: alveolar soft part sarcoma. Pediatr Dev Pathol; 2009 Mar-Apr;12(2):147-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rare tumor of the tongue in a child: alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a rare, malignant tumor of uncertain histogenesis that has no benign counterpart.
  • Because of the indolent growth and lack of pain associated with the mass, 20% of patients have metastases at the time of initial diagnosis.
  • When ASPS presents in the tongue region, however, the patients involved are usually children and have a better prognosis than patients affected in the extremities.
  • Because metastases may occur after several decades, children with ASPS should be followed throughout adolescence and well into adulthood.
  • Only 10 cases of ASPS occurring in the tongues of children younger than 5 years of age were indexed by MEDLINE between 1952 and 2006.
  • Here, we describe the 1st case consistent with typical ASPS of the tongue in 15 years at our hospital.
  • The patient is a 2-year-old girl who has been disease-free for 32 months.
  • [MeSH-major] Sarcoma / pathology. Soft Tissue Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / analysis. Child, Preschool. Cyclophosphamide / therapeutic use. Dactinomycin / therapeutic use. Disease-Free Survival. Female. Humans. Vimentin / analysis. Vincristine / therapeutic use

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  • (PMID = 18630993.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Vimentin; 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; VAC protocol
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58. Pang LJ, Chang B, Zou H, Qi Y, Jiang JF, Li HA, Hu WH, Chen YZ, Liu CX, Zhang WJ, Li F: Alveolar soft part sarcoma: a bimarker diagnostic strategy using TFE3 immunoassay and ASPL-TFE3 fusion transcripts in paraffin-embedded tumor tissues. Diagn Mol Pathol; 2008 Dec;17(4):245-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma: a bimarker diagnostic strategy using TFE3 immunoassay and ASPL-TFE3 fusion transcripts in paraffin-embedded tumor tissues.
  • Alveolar soft part sarcoma (ASPS) is a malignancy with low incidence, but with poor prognosis if misdiagnosed.
  • Immunohistochemical assay using TFE3 antibody has been shown to be a sensitive technique for ASPS diagnosis.
  • A specific chromosomal translocation, t(X;17)(p11.2;q25), results in the ASPL-TFE3 fusion gene: it is detectable using reverse-transcription polymerase chain reaction (RT-PCR) in frozen tumor tissues of ASPS.
  • However, the diagnostic usefulness of these markers has not been investigated in Chinese ASPS patients.
  • Here, we report the first systematic study applying TFE3 immunoassay and ASPL-TFE3 fusion transcript detection to archival paraffin-embedded tissues in a large Chinese ASPS patient population.
  • Sixteen patients had been diagnosed with ASPS (age, 3 to 58 y; 3 male patients and 13 female patients).
  • ASPS tumors showed the best immunoreactivity to the TFE3 antibody (16/16).
  • Using a strategy of RT-PCR, followed by a nested PCR with a different primer set, we were able to detect the expression of the chimeric ASPL-TFE3 mRNA in 11 of the 16 ASPS tumors.
  • Our results demonstrate that the "bimarker strategy," a combination of TFE3 immunostaining and ASPL-TFE3 chimeric transcript detection, might have sufficient sensitivity and specificity in diagnosing most of the ASPSs.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / analysis. Oncogene Proteins, Fusion / genetics. Pathology, Surgical / methods. RNA Precursors / analysis. Sarcoma, Alveolar Soft Part / diagnosis

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  • (PMID = 18382356.001).
  • [ISSN] 1533-4066
  • [Journal-full-title] Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • [ISO-abbreviation] Diagn. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / RNA Precursors; 0 / TFE3 protein, human
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59. do Nascimento Souza KC, Faria PR, Costa IM, Duriguetto AF Jr, Loyola AM: Oral alveolar soft-part sarcoma: review of literature and case report with immunohistochemistry study for prognostic markers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Jan;99(1):64-70
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  • [Title] Oral alveolar soft-part sarcoma: review of literature and case report with immunohistochemistry study for prognostic markers.
  • OBJECTIVE: To describe a case of alveolar soft-part sarcoma (ASPS) affecting the tongue of a child and to study prognostic imunohistochemical markers for the disease.
  • STUDY DESIGN: Tissue sections were incubated with primary antibodies reactive to neuron-specific enolase (NSE), vimentin, desmin, S-100 protein, cytokeratins AE1-AE3, EMA, neurofilament, synaptophysin, and muscle-specific actin (MSA), and for prognostic markers, including Ki-67, p53, bcl-2, bax, and nm23.
  • RESULTS: Histologically, the tumor showed a proliferation of large polygonal cells with PAS-positive diastase-resistant intracytoplasmatic material, arranged in an alveolar growth pattern.
  • CONCLUSION: These immunohistochemical findings may reflect the less aggressive behavior of ASPS in oral tissues.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Tongue Neoplasms / pathology

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  • (PMID = 15599350.001).
  • [ISSN] 1079-2104
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, Neoplasm; 0 / BAX protein, human; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / Ki-67 Antigen; 0 / Mucin-1; 0 / NM23 Nucleoside Diphosphate Kinases; 0 / Neurofilament Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / S100 Proteins; 0 / Synaptophysin; 0 / Tumor Suppressor Protein p53; 0 / Vimentin; 0 / bcl-2-Associated X Protein; 68238-35-7 / Keratins; EC 2.7.4.6 / NME1 protein, human; EC 2.7.4.6 / Nucleoside-Diphosphate Kinase; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Number-of-references] 42
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60. Baglam T, Kalender ME, Durucu C, Bakir K, Karatas E, Kara F, Kanlikama M: Alveolar soft part sarcoma of the tongue. J Craniofac Surg; 2009 Nov;20(6):2160-2
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  • [Title] Alveolar soft part sarcoma of the tongue.
  • Alveolar soft part sarcoma is a rare type of sarcoma that usually affects young adult women.
  • Herein, we present an unusual case of alveolar soft part sarcoma of the tongue in an 18-year-old woman.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Tongue Neoplasms / pathology

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  • (PMID = 19884839.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Balgley BM, Guo T, Zhao K, Fang X, Tavassoli FA, Lee CS: Evaluation of archival time on shotgun proteomics of formalin-fixed and paraffin-embedded tissues. J Proteome Res; 2009 Feb;8(2):917-25
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  • There is increasing acceptance of the critical importance of correlating the morphologic features of tissue with the data obtained from various molecular analytic techniques.
  • Access to archived formalin-fixed and paraffin-embedded (FFPE) tissue specimens via shotgun-based proteomic analyses may, therefore, open new avenues for both prospective and retrospective translational research.
  • Optimized protein extraction and digestion procedures for handling FFPE tissues are coupled with the capillary isotachophoresis-based proteome technology to evaluate the effects of length of storage period on archival tissue proteome analysis across 10 archived uterine mesenchymal tumor tissue blocks, including 9 uterine leiomyomas dating from 1990 to 2002 and a single case of alveolar soft part sarcoma (ASPS) from 1980.
  • Low abundance proteins may be more susceptible to the long-term storage as these proteins are more difficult to be retrieved and extracted as the tissue block ages in paraffin.
  • Despite using tissue blocks stored for as many as 28 years, high confidence and comparative proteome analysis between the leiomyomas and the sarcoma is achieved.
  • Though sharing over 1800 common proteins in a core set, a total of 80 proteins unique to the sarcoma are identified distinguishing the ASPS from the leiomyomas.
  • Vacuolar proton translocating ATPase 116 kDa subunit isoform a3, one of the unique proteins expressed in the ASPS, is further validated by immunohistochemistry (IHC).

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  • (PMID = 19128014.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM073723; United States / NCI NIH HHS / CA / R42 CA122715; United States / NIGMS NIH HHS / GM / R01 GM073723-04; United States / NCI NIH HHS / CA / R41 CA122715; United States / NCI NIH HHS / CA / CA122715; United States / NIGMS NIH HHS / GM / GM073723; United States / NIGMS NIH HHS / GM / GM073723-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Peptides; 1HG84L3525 / Formaldehyde
  • [Other-IDs] NLM/ NIHMS91394; NLM/ PMC2664629
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62. Aulmann S, Longerich T, Schirmacher P, Mechtersheimer G, Penzel R: Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. Histopathology; 2007 Jun;50(7):881-6
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  • [Title] Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.
  • AIMS: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumour with unique morphology and a recurrent, non-reciprocal translocation der(17)t(X;17)(p11.2;q25) leading to the fusion of ASPSCR1 (also known as ASPL) to the transcription factor TFE3.
  • Although diagnosis is straightforward in classical cases, tumours with atypical morphological features may be difficult to classify solely on the basis of conventional histopathology.
  • The aim of this study was to analyse the chromosomal breakpoints in paraffin-embedded tissue.
  • METHODS AND RESULTS: Three male and two female ASPS patients including one case with uncommon histology were investigated by fluorescence in situ hybridization with split- and fusion-probes.
  • Hybridization results showed a t(X;17)(p11.2;q25) in all tumours with a duplication of the telomeric part of chromosome Xp.
  • CONCLUSIONS: Molecular confirmation of ASPSCR1-TFE3 gene fusion is applicable to routinely processed archival and diagnostic tumour samples and aids in the differential diagnosis of ASPS.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Neoplasm Proteins / genetics. Oncogene Fusion. Oncogene Proteins, Fusion / genetics. Sarcoma, Alveolar Soft Part / genetics. Soft Tissue Neoplasms / genetics

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  • (PMID = 17543078.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
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63. Luo J, Melnick S, Rossi A, Burke RP, Pfeifer JD, Dehner LP: Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration. Pediatr Dev Pathol; 2008 Mar-Apr;11(2):142-7
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  • [Title] Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration.
  • A case of primary alveolar soft part sarcoma (ASPS) of the heart is reported in an 11-year-old female as 1 of 16 cases of ASPS presenting in the first 2 decades of life in our institutional 17-year review period.
  • The classic alveolar or organoid pattern was inconspicuous as compared to a more diffuse or formless pattern consisting of a population of uniform round cells with abundant eosinophilic cytoplasm, but in addition there was a second, minor population of gigantiform tumor cells with a variety of unusual shapes.
  • Other unusual features for ASPS in our case included a lymphohistocytic reaction and zonal necrosis.
  • The only other examples of ASPS involving the heart were 3 cases in the literature of metastatic disease from tumors arising in the soft tissues.
  • This initial case of primary cardiac ASPS joins the list of other types of sarcomas in children that have been reported as primary neoplasms of the heart.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Heart Neoplasms / pathology. Neoplasm Proteins / genetics. Oncogene Proteins, Fusion / genetics. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17378669.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Neoplasm; 0 / TFE3 protein, human
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64. Costa AF, Gasser RB, Dias SR, Rabelo EM: Male-enriched transcription of genes encoding ASPs and Kunitz-type protease inhibitors in Ancylostoma species. Mol Cell Probes; 2009 Dec;23(6):298-303

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  • [Title] Male-enriched transcription of genes encoding ASPs and Kunitz-type protease inhibitors in Ancylostoma species.
  • Specifically, partial cDNA sequences encoding three different ASP molecules and two different Kunitz-type protease inhibitors were isolated, and the differential transcription between adult male and female worms was compared by conventional and quantitative reverse transcription (RT)-PCR for three species, A. braziliense, Ancylostoma caninum and Ancylostoma ceylanicum.

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  • (PMID = 19646525.001).
  • [ISSN] 1096-1194
  • [Journal-full-title] Molecular and cellular probes
  • [ISO-abbreviation] Mol. Cell. Probes
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ FJ593957/ FJ593958/ FJ593959/ FJ593960
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Complementary; 0 / Helminth Proteins; 0 / Serine Proteinase Inhibitors
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65. Huang HJ, Jiang CH, Chen SJ: [Alveolar soft part sarcoma of the tongue root: a case report]. Hua Xi Kou Qiang Yi Xue Za Zhi; 2008 Aug;26(4):454-6
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  • [Title] [Alveolar soft part sarcoma of the tongue root: a case report].
  • Alveolar soft part sarcoma is a rare, aggressive malignancy of uncertain histological origin with a propensity for vascular invasion and distant metastasis.
  • The case presented involves a 31-year-old woman with alveolar soft part sarcoma in the tongue root.
  • The clinical features, pathogenesis, diagnosis and treatment were discussed.
  • [MeSH-major] Sarcoma, Alveolar Soft Part. Tongue Neoplasms

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  • (PMID = 18780514.001).
  • [ISSN] 1000-1182
  • [Journal-full-title] Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
  • [ISO-abbreviation] Hua Xi Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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66. Trabelsi A, Ben Abdelkrim S, Taher Yacoubi M, Mlika S, Hmissa S, Mokni M, Korbi S: [Primary alveolar soft part sarcoma of the lung]. Rev Mal Respir; 2009 Mar;26(3):329-32
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  • [Title] [Primary alveolar soft part sarcoma of the lung].
  • [Transliterated title] Sarcome alvéolaire primitif du poumon.
  • BACKGROUND: Alveolar soft part sarcoma is rare; it mainly appears in the lower extremities in adults and the head and neck in children.
  • Diagnosis of primary alveolar sarcoma of the lung was made by histological examination of a biopsy specimen and elimination of a primary soft tissue tumour elsewhere.
  • CONCLUSION: Primary alveolar sarcoma of the lung is exceptionally rare and the diagnosis should only be made after eliminating a soft tissue tumour elsewhere.
  • [MeSH-major] Lung Neoplasms / pathology. Sarcoma, Alveolar Soft Part / pathology

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  • (PMID = 19367208.001).
  • [ISSN] 0761-8425
  • [Journal-full-title] Revue des maladies respiratoires
  • [ISO-abbreviation] Rev Mal Respir
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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67. Stacchiotti S, Tamborini E, Marrari A, Brich S, Rota SA, Orsenigo M, Crippa F, Morosi C, Gronchi A, Pierotti MA, Casali PG, Pilotti S: Response to sunitinib malate in advanced alveolar soft part sarcoma. Clin Cancer Res; 2009 Feb 1;15(3):1096-104
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  • [Title] Response to sunitinib malate in advanced alveolar soft part sarcoma.
  • PURPOSE: Alveolar soft part sarcoma (ASPS) is a rare, chemoresistant soft tissue sarcoma.
  • ASPS harbors the t(17-X) (p11.2;q25) translocation, resulting in the ASPACR1-TFE3 fusion protein, causing MET autophosphorylation and activation of downstream signaling.
  • EXPERIMENTAL DESIGN: Since July 2007, five patients with progressive metastatic ASPS have been treated with continuous SM 37.5 mg/d on a named basis.
  • One had a RECIST stable disease.
  • CONCLUSION: SM may have antitumor activity in ASPS, possibly through a mechanism involving PDGFR and RET.
  • [MeSH-major] Indoles / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Pyrroles / therapeutic use. Sarcoma, Alveolar Soft Part / drug therapy

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  • (PMID = 19188185.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indoles; 0 / Protein Kinase Inhibitors; 0 / Pyrroles; 0 / sunitinib; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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68. Madrigrano A, Beach B, Wheeler A, Wapnir I: Metastases to the breast: alveolar soft part sarcoma in adolescents. Clin Breast Cancer; 2008 Feb;8(1):92-3
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  • [Title] Metastases to the breast: alveolar soft part sarcoma in adolescents.
  • This is a case report of an 18-year-old woman with an alveolar soft part sarcoma metastatic to the breast.
  • [MeSH-major] Breast Neoplasms / secondary. Sarcoma, Alveolar Soft Part / secondary. Skin Neoplasms / pathology


69. Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Laé M, Fisher DE, Ladanyi M: TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res; 2007 Feb 1;67(3):919-29
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Oncogenic TFE3 fusion proteins define a subset of pediatric renal adenocarcinomas and one fusion (ASPL-TFE3) is also characteristic of alveolar soft part sarcoma (ASPS).
  • By expression profiling, we identified the MET receptor tyrosine kinase gene as significantly overexpressed in ASPS relative to four other types of primitive sarcomas.
  • [MeSH-minor] Animals. COS Cells. Cell Growth Processes / drug effects. Cell Growth Processes / physiology. Cercopithecus aethiops. HeLa Cells. Humans. Indoles / pharmacology. Phosphorylation. Promoter Regions, Genetic. Sarcoma / enzymology. Sarcoma / genetics. Sarcoma / metabolism. Sarcoma / pathology. Signal Transduction. Sulfones / pharmacology. Transcription, Genetic. Up-Regulation

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  • (PMID = 17283122.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 100400; United States / NCI NIH HHS / CA / CA 102309; United States / NCI NIH HHS / CA / CA 97585
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Indoles; 0 / Oncogene Proteins, Fusion; 0 / Sulfones; 0 / TFE3 protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-met
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70. Salvati M, D'Elia A, Frati A, Santoro A: Sarcoma metastatic to the brain: a series of 35 cases and considerations from 27 years of experience. J Neurooncol; 2010 Jul;98(3):373-7
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  • [Title] Sarcoma metastatic to the brain: a series of 35 cases and considerations from 27 years of experience.
  • The authors report their 27-year experience regarding 35 cases of supratentorial brain metastasis from sarcoma treated in a single institution: these included ten osteosarcomas, seven leiomyosarcomas, five Ewing sarcomas, four malignant fibrous histiocytomas, three alveolar soft-part sarcomas (ASPS), two rhabdomyosarcomas, one liposarcoma, and three unclassified sarcomas.
  • Of the three patients with ASPS, the first two were alive at 15 and 20 months (before being lost to follow-up) whereas the third patient is alive at 24 month follow-up.
  • The authors conclude that surgery is more effective in treating selected patients with sarcoma metastatic to the brain, and that patients with metastasis from ASPS have good prognosis when submitted to surgical treatment.
  • Finally, it seems that surgical indications for multiple brain metastases from sarcoma have increased during the last ten years.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / therapy. Cranial Irradiation / methods. Sarcoma / pathology

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  • (PMID = 20039192.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Günay C, Atalar H, Kaygusuz G, Yildiz Y, Sağlik Y: [Alveolar soft part sarcoma of the extremities: an evaluation of four cases]. Acta Orthop Traumatol Turc; 2007 Aug-Oct;41(4):326-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Alveolar soft part sarcoma of the extremities: an evaluation of four cases].
  • We presented four patients (3 women, 1 man; mean age 40 years; range 20 to 56 years) who had alveolar soft part sarcoma in the left arm, right elbow, right tibia, and left thigh, respectively.
  • Two patients had lung metastasis at the time of diagnosis.
  • T1- and T2-weighted magnetic resonance images of all the patients showed a soft tissue lesion with hyperintense signal changes and heterogeneous contrast enhancement.
  • Two patients with involvement of the left arm and right elbow died within three years after diagnosis.
  • One patient with tibial involvement remained disease-free during 10 months of follow-up.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Arm. Diagnosis, Differential. Elbow. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Metastasis. Thigh. Tibia

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  • (PMID = 18180565.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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72. Aisner SC, Beebe K, Blacksin M, Mirani N, Hameed M: Primary alveolar soft part sarcoma of fibula demonstrating ASPL-TFE3 fusion: a case report and review of the literature. Skeletal Radiol; 2008 Nov;37(11):1047-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary alveolar soft part sarcoma of fibula demonstrating ASPL-TFE3 fusion: a case report and review of the literature.
  • Alveolar soft part sarcoma is a rare soft tissue tumor typically affecting young adults.
  • These tumors are most often seen in the deep soft tissues of the extremities and patients generally present with advanced disease.
  • This is the first case of alveolar soft part sarcoma in bone documenting the ASPL-TFE3 gene product.
  • Herein, we report a rare presentation of alveolar soft part sarcoma presenting as a primary bone neoplasm involving the proximal fibula in a 41-year-old woman.
  • [MeSH-major] Fibula / pathology. Sarcoma, Alveolar Soft Part / diagnosis
  • [MeSH-minor] Adult. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Oncogene Proteins, Fusion. Tomography, X-Ray Computed

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  • [Cites] Skeletal Radiol. 2000 Dec;29(12 ):680-9 [11271548.001]
  • [Cites] Skeletal Radiol. 1993;22(5):386-9 [8372371.001]
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  • (PMID = 18594808.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Oncogene Proteins, Fusion; 0 / TFE3 protein, human
  • [Number-of-references] 23
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73. Shaddix KK, Fakhre GP, Nields WW, Steers JL, Hewitt WR, Menke DM: Primary alveolar soft-part sarcoma of the liver: anomalous presentation of a rare disease. Am Surg; 2008 Jan;74(1):43-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary alveolar soft-part sarcoma of the liver: anomalous presentation of a rare disease.
  • Alveolar soft-part sarcoma is a highly vascular soft-tissue tumor that is uniformly malignant.
  • It comprises less than 1 per cent of all soft-tissue sarcomas.
  • Patients with alveolar soft-part sarcoma most frequently are aged 15 to 35 years, and the soft tissues of the lower extremities typically are affected.
  • Alveolar soft-part sarcoma has been described as a primary lesion in the trunk, upper extremities, and retroperitoneum; more novel locations include the mediastinum, female genital tract, stomach, bone, and larynx.
  • Numerous case reports describe alveolar soft-part sarcoma in diverse anatomic locations, but this report is, to our knowledge, the first documentation of primary alveolar soft-part sarcoma of the liver.
  • Despite surgical resection and numerous chemotherapeutic regimens, this patient had widespread metastasis and died approximately 2 years after the diagnosis was established.
  • [MeSH-major] Liver Neoplasms / diagnosis. Sarcoma, Alveolar Soft Part / diagnosis

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  • (PMID = 18274427.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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74. Xu LB, Yu SJ, Shao YF, Zhang HT, Zhao ZG: [Clinical features and prognosis of alveolar soft part sarcoma]. Zhonghua Zhong Liu Za Zhi; 2007 Oct;29(10):778-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical features and prognosis of alveolar soft part sarcoma].
  • OBJECTIVE: To investigate the clinical feature, suitable treatment and prognosis of alveolar soft part sarcoma.
  • CONCLUSION: Alveolar soft part sarcoma usually grows slowly.
  • To achieve microscopically complete resection is quite critical to localized alveolar soft part sarcoma.
  • [MeSH-major] Lung Neoplasms / secondary. Sarcoma, Alveolar Soft Part / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 18396693.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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75. Raghunandhan S, Murali S, Nagasundaram J, Sudha Maheswari S, Kameswaran M: Alveolar soft part sarcoma of tongue base - A rare presentation of a rare tumor. Indian J Otolaryngol Head Neck Surg; 2007 Dec;59(4):393-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of tongue base - A rare presentation of a rare tumor.
  • Alveolar soft part sarcoma is a rare, aggressive malignancy of uncertain histologic origin and enigmatic clinical behaviour.
  • We report a case of alveolar soft part sarcoma involving the tongue base in an adolescent female.

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  • [Cites] Skeletal Radiol. 1995 May;24(4):267-70 [7644939.001]
  • (PMID = 23120485.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452256
  • [Keywords] NOTNLM ; Immunohistochemistry / Lingual Alveolar Soft Part Sarcoma (ASPS)
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76. Pennacchioli E, Fiore M, Collini P, Radaelli S, Dileo P, Stacchiotti S, Casali PG, Gronchi A: Alveolar soft part sarcoma: clinical presentation, treatment, and outcome in a series of 33 patients at a single institution. Ann Surg Oncol; 2010 Dec;17(12):3229-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma: clinical presentation, treatment, and outcome in a series of 33 patients at a single institution.
  • BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor that usually affects young patients.
  • A comprehensive retrospective review was performed of clinical presentation, treatment, outcome, and patterns of failure in a consecutive series of patients with localized or metastatic ASPS between 1975 and 2008.
  • METHODS: Demographics, tumor sizes, sites and extent of disease, treatments provided, progression-free survival, and overall survival were evaluated.
  • CONCLUSIONS: Prognosis of ASPS is basically related to the characteristics of the disease and the quality of surgery.
  • New agents are eagerly needed to complement surgery to eradicate this disease.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / therapy

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  • (PMID = 20593242.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Daigeler A, Kuhnen C, Hauser J, Goertz O, Tilkorn D, Steinstraesser L, Steinau HU, Lehnhardt M: Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases. World J Surg Oncol; 2008;6:71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases.
  • BACKGROUND: Alveolar sarcoma of the soft parts (ASPS) represents a very rare entity of soft tissue sarcoma with special features such as young peak age incidence and frequent metastasis to the brain.
  • METHODS: From the database of the BG-University Hospital Bergmannsheil, 1597 soft tissue sarcoma (STS) cases were reviewed and 11 consecutive patients with ASPS were isolated.
  • RESULTS: Patients with localized disease who received complete resection and adjuvant radiation and who did not develop recurrence or metastatic disease within 2 years after surgery had a positive outcome.
  • All patients who developed recurrent disease also suffered from distant metastasis, reflecting the aggressive biology of the tumor.
  • CONCLUSION: Due to the limited number of patients with ASPS, prospective studies would have to span decades to gather a significant collective of patients; therefore, it is not possible to comment meaningfully on a possible benefit of neoadjuvant or adjuvant therapy.
  • In cases with recurrent disease or metastasis, the prognosis is bad and further treatment will be restricted to palliation in most cases.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / therapy

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  • (PMID = 18593459.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2459182
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78. Silas OA, Adoga AA, Manasseh AN, Echejoh GO, Vhriterhire RA, Mandong BM: Persistent alveolar soft-part sarcoma with liver metastasis: a case report. J Med Case Rep; 2010;4:233

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent alveolar soft-part sarcoma with liver metastasis: a case report.
  • INTRODUCTION: Alveolar soft-part sarcomas are rare, slow-growing tumors that metastasize commonly via vascular routes to the lungs, bones, lymph nodes and brain, causing morbidity and mortality.
  • It was initially diagnosed as soft-tissue sarcoma, and its associated systemic effects lead to his death before a histological diagnosis could be obtained.
  • CONCLUSIONS: Alveolar soft-part sarcoma with metastasis to the liver can occur in our region (northeast Africa), and a high index of suspicion is required to make an early diagnosis, followed by prompt surgical excision with clear margins in order to prevent mortality.

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  • (PMID = 20673324.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2922299
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79. Kayton ML, Meyers P, Wexler LH, Gerald WL, LaQuaglia MP: Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults. J Pediatr Surg; 2006 Jan;41(1):187-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults.
  • PURPOSE: Alveolar soft part sarcoma is a rare soft tissue neoplasm that can affect children and adolescents.
  • To define the clinical presentation, treatment, and outcome of young people with this rare sarcoma, we reviewed our clinical experience.
  • METHODS: After institutional review board approval, we examined the records of all patients younger than 25 years old who received treatment at our institution for alveolar soft part sarcoma in the past 30 years.
  • Demographics, tumor sizes, sites and extent of disease, treatments used, progression-free survival, and overall follow-up were evaluated.
  • Primary disease sites were thigh (n = 8), trunk (n = 6), retroperitoneum (n = 2), and scalp, neck, forearm, and calf (n = 1 each).
  • Although wide local excision provided the best chance for a patient to remain free of disease, 14 (70%) of 20 patients exhibited metastases either at presentation or later.
  • Younger patients tended to have Intergroup Rhabdomyosarcoma Study group I disease.
  • CONCLUSIONS: Achievement of complete microscopic resection is critical in localized alveolar soft part sarcoma, but incomplete excision and misdiagnosis are often encountered.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / surgery
  • [MeSH-minor] Adolescent. Adult. Age Factors. Child. Disease Progression. Embolization, Therapeutic. Female. Follow-Up Studies. Humans. Male. Neoplasm Metastasis. Retrospective Studies. Survival Analysis. Treatment Outcome


80. Noussios G, Chouridis P, Petropoulos I, Karagiannidis K, Kontzoglou G: Alveolar soft part sarcoma of the tongue in a 3-year-old boy: a case report. J Med Case Rep; 2010;4:130

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the tongue in a 3-year-old boy: a case report.
  • INTRODUCTION: Alveolar soft tissue sarcoma of the tongue is a very rare and aggressive tumor which occurs in infancy with a relatively controversial histogenesis.
  • CASE PRESENTATION: We present the case of a three-year-old Caucasian boy who was admitted to our department with a history of dysphagia and two episodes of oral bleeding which had lasted for a period of six months.
  • A thorough histological examination together with imaging techniques form the basis of a reliable diagnosis.
  • CONCLUSION: Alveolar soft tissue sarcoma of the tongue is a rare tumor which occurs in infancy and which is often misdiagnosed pre-operatively.
  • It should therefore be included in the differential diagnosis of oral pediatric lesions.

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  • (PMID = 20459684.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2873458
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81. Owens RC Jr, Shorr AF, Deschambeault AL: Antimicrobial stewardship: shepherding precious resources. Am J Health Syst Pharm; 2009 Jun 15;66(12 Suppl 4):S15-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Differences in antimicrobial stewardship program (ASP) strategies, evidences supporting the benefits of ASPs, barriers to implementing ASPs, and suggestions for overcoming the barriers are discussed.
  • Prior authorization and prospective audit with feedback are two distinct methods of ASPs.
  • Supplemental and combined strategies of ASPs also exist.
  • Tangible benefits have been demonstrated with using ASPs, such as a reduction in antimicrobial consumption and reductions in costs.
  • However, barriers to ASP implementation exist such as acquiring funding for an ASP, a lack of pharmacy leadership supporting ASPs, a shortage of adequately trained infectious disease physicians and pharmacists, competition for funding with other programs in the hospital, and communicating with antagonizing colleagues.
  • CONCLUSION: In the setting of increasing antimicrobial resistance, ASPs provide a formalized, practical, and manageable approach to improving the use of antimicrobials in our health care systems where their use is widespread and often suboptimal.

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  • (PMID = 19502223.001).
  • [ISSN] 1535-2900
  • [Journal-full-title] American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • [ISO-abbreviation] Am J Health Syst Pharm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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82. Hanson MD, Niec A, Pietrantonio AM, Johnson S, Young M, High B, MacMillan H, Eva KW: Effects associated with adolescent standardized patient simulation of depression and suicidal ideation. Acad Med; 2007 Oct;82(10 Suppl):S61-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Because of common use of adolescent simulated patients (ASPs), clarification of the risk of negative effects associated with high-stress simulations is essential.
  • METHOD: ASPs participated in a suicidality role or pediatric role.
  • ASPs in the suicidality role showed behavioral effects consistent with a negative reaction, and two reported brief depression.
  • CONCLUSIONS: ASPs participated in a suicidality simulation without evidence of suicide contagion.
  • However, ASPs' behavioral reactions and self-reported depression suggested a transient depressive reaction.


83. Hanson MD, Johnson S, Niec A, Pietrantonio AM, High B, MacMillan H, Eva KW: Does mental illness stigma contribute to adolescent standardized patients' discomfort with simulations of mental illness and adverse psychosocial experiences? Acad Psychiatry; 2008 Mar-Apr;32(2):98-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: ASPs were randomly assigned to one of two simulation conditions: one was associated with mental illness stigma and one was not.
  • After training, ASPs completed the adapted Project Role Questionnaire to rate anticipated role discomfort with hypothetical adolescent psychiatric conditions/adverse psychosocial experiences and to respond to open-ended questions regarding this discomfort.
  • RESULTS: Twenty-four ASPs participated.
  • A significant effect of simulation was observed, indicating that ASPs participating in the simulation associated with mental illness stigma anticipated greater comfort with portraying subsequent stigma-associated roles than did ASPs in the simulation not associated with stigma.
  • ASPs' narrative responses regarding their reasons for anticipating discomfort focused upon the role of knowledge-related factors.
  • CONCLUSION: ASPs' work with a psychiatric case simulation was associated with greater anticipated comfort with hypothetical simulations of psychiatric/adverse psychosocial conditions in comparison to ASPs lacking a similar work experience.
  • The ASPs provided explanations for this anticipated discomfort that were suggestive of stigma-related knowledge factors.
  • [MeSH-major] Adaptation, Psychological. Adolescent Psychiatry / education. Depressive Disorder / psychology. Patient Simulation. Prejudice. Psychology, Adolescent. Suicide / psychology

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  • (PMID = 18349328.001).
  • [ISSN] 1042-9670
  • [Journal-full-title] Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
  • [ISO-abbreviation] Acad Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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84. Cunha IW, Lopes A, Falzoni R, Soares FA: Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS. Appl Immunohistochem Mol Morphol; 2006 Dec;14(4):404-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sarcomas often express constitutive nitric oxide synthases (NOS) but infrequently inducible NOS.
  • NO is produced by nitric oxide synthases (NOS).
  • There are three enzyme isoforms: two of them are constitutively produced (neuronal or brain NOS and endothelial NOS), and one is an inducible form (iNOS).
  • NOS expression has been shown in several epithelial tumors, but there is no report addressing NOS expression in sarcomas.
  • The authors evaluated the expression of NOS in 97 cases of various sarcomas spotted in duplicate in a tissue array paraffin block.
  • Only chondrosarcomas and liposarcomas had significant numbers of negative cases, and all pleomorphic sarcomas, alveolar soft part sarcomas, angiosarcomas, gastrointestinal stromal tumors, and synovial sarcomas showed some degree of positivity.
  • Forty-three cases (44.4%) showed eNOS immunostaining, but only 15.5% showed a strong signal, with emphasis on angiosarcomas, chondrosarcomas, alveolar soft part sarcomas, and synovial sarcoma.
  • Strong expression of iNOS was found in malignant peripheral nerve sheet tumors, liposarcomas, pleomorphic sarcomas, fibrosarcomas, chondrosarcomas, and synovial sarcomas.
  • Apparently alveolar soft part sarcomas are unusual in their capacity of expression of NOS isoforms, and in a very peculiar pattern.
  • In conclusion, sarcomas in general commonly express constitutive NOS, and only a few types of sarcomas can express iNOS, the isoenzymes capable of releasing large amounts of NO.
  • More comprehensive studies should be performed to better understand the clinical importance of NOS expression and NO production in sarcomas.

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  • (PMID = 17122636.001).
  • [ISSN] 1541-2016
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 1.14.13.39 / Nitric Oxide Synthase Type I; EC 1.14.13.39 / Nitric Oxide Synthase Type III
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85. Black WD, Studdert MJ: Formerly unclassified, acid-stable equine picornaviruses are a third equine rhinitis B virus serotype in the genus Erbovirus. J Gen Virol; 2006 Oct;87(Pt 10):3023-7
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Acid-stable equine picornaviruses (ASPs) were identified as a distinct serotype of equine picornaviruses that were isolated from nasal swabs taken from horses with acute febrile respiratory disease in the UK and Japan, and were placed in the group of unclassified picornaviruses.
  • The ASPs belong to the same phylogenetic group, composed of five acid-stable ERBV1 isolates.
  • ERBV1 rabbit antiserum neutralized the ASP isolates at approximately 1/10 titre relative to acid-stable and acid-labile ERBV1 isolates, supporting prior findings that ASPs are a distinct serotype, albeit cross-neutralizing weakly with ERBV1.

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  • (PMID = 16963761.001).
  • [ISSN] 0022-1317
  • [Journal-full-title] The Journal of general virology
  • [ISO-abbreviation] J. Gen. Virol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ DQ108383/ DQ108384/ DQ108385
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Acids; 0 / Viral Structural Proteins
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86. Liu PJ, Hsieh WT, Huang SH, Liao HF, Chiang BH: Hematopoietic effect of water-soluble polysaccharides from Angelica sinensis on mice with acute blood loss. Exp Hematol; 2010 Jun;38(6):437-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: The crude extract of Angelica sinensis (AS) was separated into two fractions, polysaccharides (ASPS) and small molecular weight compounds.
  • The AS, ASPS, and small molecular weight compounds were incubated with mice spleen cells to obtain conditioned mediums, and then their hematopoietic activities were evaluated by granulocyte macrophage (GM) colony-forming assay in vitro.
  • RESULTS: We found that polysaccharide (ASPS) was the major component responsible for the hematopoietic effect of Angelica sinensis.
  • Administration of low-dose ASPS (2.3 mg ASPS/kg body weight per day) could significantly accelerate the recovery of hemoglobin level of the blood-loss mice to its original value, as compared to the control (p < 0.05).
  • Moreover, the colony-forming ability of bone marrow cells that were removed from mice that received ASPS was also markedly increased (p < 0.05) during ex vivo test.
  • CONCLUSIONS: Results of this study demonstrated the potential of ASPS for treatment of anemia.

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  • [Copyright] Copyright 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20347925.001).
  • [ISSN] 1873-2399
  • [Journal-full-title] Experimental hematology
  • [ISO-abbreviation] Exp. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / Hematopoietic Cell Growth Factors; 0 / Plant Extracts; 0 / Polysaccharides; 059QF0KO0R / Water
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87. Carter JE, Evans TN, Tucker JA: Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report. Acta Cytol; 2008 Jul-Aug;52(4):459-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report.
  • BACKGROUND: Alveolar soft part sarcoma is a rare soft tissue tumor of uncertain origin that is generally slow growing but unmistakably malignant due to its propensity for metastasis to lung, bone and brain early in the course of disease.
  • CASE: A 54-year-old African-American man presented to our institution with a 2-week history of left leg pain.
  • Imaging studies revealed a left leg soft tissue mass just below the popliteal fossa and multiple bilateral lung lesions suggestive of metastatic neoplasm.
  • A periodic acid-Schiff (PAS) stain highlighted intracytoplasmic rhomboidal crystals, a feature diagnostic of alveolar soft part sarcoma.
  • CONCLUSION: Alveolar soft part sarcoma may be diagnosed by its unique morphologic characteristics and should be considered in the differential diagnosis of all cytologically sampled soft tissue lesions.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biopsy. Biopsy, Fine-Needle. Diagnosis, Differential. Humans. Leg. Male. Microscopy, Electron. Middle Aged. Periodic Acid-Schiff Reaction. Tomography, X-Ray Computed

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  • (PMID = 18702365.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Drew RH: Antimicrobial stewardship programs: how to start and steer a successful program. J Manag Care Pharm; 2009 Mar;15(2 Suppl):S18-23
MedlinePlus Health Information. consumer health - Infection Control.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Antimicrobial stewardship programs (ASPs) promote the appropriate use of antimicrobials by selecting the appropriate dose, duration, and route of administration.
  • Other supplemental strategies involve education, guidelines and clinical pathways, antimicrobial order forms, de-escalation of therapy, intravenous-to-oral (IV-to-PO) switch therapy, and dose optimization.
  • Several barriers exist to successful implementation of ASPs.
  • CONCLUSION: ASPs have the potential to reduce antimicrobial resistance, health care costs, and drug-related adverse events while improving clinical outcomes.
  • The efforts and expense required to implement and maintain ASPs are more than justified given their potential benefits to both the hospital and the patient.

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  • (PMID = 19236137.001).
  • [ISSN] 1083-4087
  • [Journal-full-title] Journal of managed care pharmacy : JMCP
  • [ISO-abbreviation] J Manag Care Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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89. Liu TS, Miller TA: Economic analysis of the future growth of cosmetic surgery procedures. Plast Reconstr Surg; 2008 Jun;121(6):404e-412e
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is unknown whether this growth will continue for the next decade and, if so, what impact it will it have on the plastic surgeon workforce.
  • METHODS: The authors analyzed annual U.S. cosmetic surgery procedure volume reported by the American Society of Plastic Surgeons (ASPS) National Clearinghouse of Plastic Surgery Statistics between 1992 and 2005.
  • Reconstructive plastic surgery volume was not included in the analysis.
  • ASPS members are projected to perform 299 surgical and 2165 nonsurgical annual procedures.
  • Non-ASPS members are projected to perform 39 surgical and 1448 nonsurgical annual procedures.
  • The growth of surgical procedures will be met by ASPS members.
  • [MeSH-major] Health Services Needs and Demand / economics. Surgery, Plastic / economics. Surgery, Plastic / trends

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  • (PMID = 18520867.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Meyvis Y, Callewaert N, Gevaert K, Timmerman E, Van Durme J, Schymkowitz J, Rousseau F, Vercruysse J, Claerebout E, Geldhof P: Hybrid N-glycans on the host protective activation-associated secreted proteins of Ostertagia ostertagi and their importance in immunogenicity. Mol Biochem Parasitol; 2008 Sep;161(1):67-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Previous vaccination trials with calves have shown that intramuscular immunization with natively purified activation-associated secreted proteins (ASPs) of Ostertagia ostertagi induces protection against a homologous challenge infection with a 74% reduction in cumulative faecal egg counts and a significant reduction in worm length.
  • However, immunized calves failed to recognize native ASPs and no protection was observed.
  • Therefore, we investigated whether glycans and/or structural epitopes are key features in the induction of a protective immune response.
  • The results show that ASPs carry two hybrid N-glycosylations with a complex alpha-1,3-arm, an unprocessed alpha-1,6-arm and an alpha-1,6-fucose core.

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  • [ErratumIn] Mol Biochem Parasitol. 2009 Feb;163(2):127
  • (PMID = 18585797.001).
  • [ISSN] 0166-6851
  • [Journal-full-title] Molecular and biochemical parasitology
  • [ISO-abbreviation] Mol. Biochem. Parasitol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Helminth; 0 / Antigens, Helminth; 0 / Polysaccharides; 0 / Recombinant Proteins
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91. Njoku JC, Hermsen ED: Antimicrobial stewardship in the intensive care unit: a focus on potential pitfalls. J Pharm Pract; 2010 Feb;23(1):50-60
MedlinePlus Health Information. consumer health - Infection Control.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thus, many health care institutions have adopted antimicrobial stewardship programs (ASPs) as a mechanism to ensure more appropriate antimicrobial use.
  • ASPs can have a significant impact in the ICU, leading to improved antimicrobial use and resistance patterns and decreased infection rates and costs, due to the inherent nature of infections encountered and high and often inappropriate antibiotic utilization in this setting.
  • However, certain challenges exist for ASPs in the ICU including issues with infrastructure and personnel, information technology, the core ASP strategy, patient-specific factors, conversion of intravenous to oral therapy, and dose optimization.

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  • [Copyright] © The Author(s) 2010
  • (PMID = 21507793.001).
  • [ISSN] 1531-1937
  • [Journal-full-title] Journal of pharmacy practice
  • [ISO-abbreviation] J Pharm Pract
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents
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92. De Geest S, Sullivan Marx EM, Rich V, Spichiger E, Schwendimann R, Spirig R, Van Malderen G: Developing a financial framework for academic service partnerships: models of the United States and Europe. J Nurs Scholarsh; 2010 Sep 1;42(3):295-304
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Academic service partnerships (ASPs) are structured linkages between academe and service which have demonstrated higher levels of innovation.
  • In the absence of descriptions in the literature on financial frameworks to support ASPs, the purpose of this paper is to present the supporting financial frameworks of a Swiss and a U.S. ASP.
  • The U.S. model presented consists of a variety of ASPs, all linked to the School of Nursing of the University of Pennsylvania.
  • Joint appointments are used as an instrument to realize these ASPs.
  • CONCLUSIONS: In operationalizing an ASP, careful budgetary planning should be an integral part of the preparation and evaluation of the collaboration.

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  • (PMID = 20738740.001).
  • [ISSN] 1547-5069
  • [Journal-full-title] Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing
  • [ISO-abbreviation] J Nurs Scholarsh
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Jianhua C, Yujun W, Ruibo J, Min W, Wutong W: Probing the antigenicity of E. coli L-asparaginase by mutational analysis. Mol Biotechnol; 2006 May;33(1):57-65

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Four mutant recombinant L-ASPs were constructed and expressed in E. coli, and then purified.
  • The activities of wild-type and mL-ASPs in the fermentative medium were all about 130 U/mL.

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  • (PMID = 16691007.001).
  • [ISSN] 1073-6085
  • [Journal-full-title] Molecular biotechnology
  • [ISO-abbreviation] Mol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens; 0 / Cell Extracts; 0 / Recombinant Proteins; EC 3.5.1.1 / Asparaginase
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94. Hersh AL, Beekmann SE, Polgreen PM, Zaoutis TE, Newland JG: Antimicrobial stewardship programs in pediatrics. Infect Control Hosp Epidemiol; 2009 Dec;30(12):1211-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To describe the prevalence, characteristics, and barriers to implementation of antimicrobial stewardship programs (ASPs) in pediatrics.
  • RESULTS: Of 246 pediatric infectious disease consultants surveyed, 147 (60%) responded.
  • The percentage of respondents from freestanding children's hospitals who were planning ASPs was higher than the percentage of respondents from other settings who were planning ASPs (P = .04).
  • Many programs were not monitoring important end points associated with ASPs, including cost and number of antibiotic-days.
  • CONCLUSIONS: The prevalence of ASPs in pediatrics is limited, and opportunities exist to improve current programs.

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  • (PMID = 19852666.001).
  • [ISSN] 1559-6834
  • [Journal-full-title] Infection control and hospital epidemiology
  • [ISO-abbreviation] Infect Control Hosp Epidemiol
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / T32HD044331; United States / NCPDCID CDC HHS / CI / U50 CI000358
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents
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95. Gurunluoglu R: Panniculectomy and redundant skin surgery in massive weight loss patients: current guidelines and recommendations for medical necessity determination. Ann Plast Surg; 2008 Dec;61(6):654-7
MedlinePlus Health Information. consumer health - Weight Loss Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • There is certain insurance coverage criteria for panniculectomy and redundant skin surgery that every plastic surgeon participating in the surgical treatment of massive weight loss patients should be familiar with to accurately document and present the clinical findings of their patients.
  • In addition, insurance coverage criteria for redundant skin surgery and panniculectomy recommended by American Society of Plastic Surgeons (ASPS) for third-party payers were reviewed.
  • Although the criteria used by third-party payers are conceptually similar to those recommended by ASPS, in practice they are harder to meet by most weight loss patients.
  • This discrepancy leads to a group of denied patients who would otherwise be authorized for plastic surgery after massive weight loss, when actual ASPS recommendations are taken into consideration.
  • This review article points out to the fact that there is a need for development of new set of guidelines for those sites and for modification of current guidelines for medical necessity determination of panniculectomy used among third-party payers, according to actual ASPS recommendations.

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  • (PMID = 19034082.001).
  • [ISSN] 1536-3708
  • [Journal-full-title] Annals of plastic surgery
  • [ISO-abbreviation] Ann Plast Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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96. Howson JM, Barratt BJ, Todd JA, Cordell HJ: Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci. Genet Epidemiol; 2005 Jul;29(1):51-67
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We compared different ascertainment schemes for genetic association analysis: affected sib-pairs (ASPs), case-parent trios, and unrelated cases and controls.
  • We found, with empirical type 1 diabetes data at four known disease loci, that studies based on case-parent trios and on unmatched cases and controls often gave higher odds ratio estimates and stronger significance test values than ASP designs.
  • We used simulations and a simplified disease model involving two interacting loci, one of large effect and one smaller, to examine interaction models that could cause such an effect.
  • ASPs showed the greatest power for association testing under most models of interaction except under additive and certain epistatic crossover models, for which case/controls and case-parent trios did better.
  • Under nonmultiplicative interactions, GRRs at the minor locus as estimated from ASPs could be biased upwards or downwards, resulting in either an increase or decrease in power compared to the case/control or trio design.
  • For the four known type 1 diabetes loci, we observed decreased risks with ASPs, which could be due to additive interactions with the remaining susceptibility loci.
  • Thus, the optimal ascertainment strategy in genetic association studies depends on the unknown underlying multilocus genetic model, and on whether the goal of the study is to detect an effect or to accurately estimate the resulting disease risks.
  • [MeSH-major] Diabetes Mellitus, Type 1 / genetics. Genetic Linkage / genetics. Genetic Predisposition to Disease / genetics

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15892093.001).
  • [ISSN] 0741-0395
  • [Journal-full-title] Genetic epidemiology
  • [ISO-abbreviation] Genet. Epidemiol.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 074524; United Kingdom / Wellcome Trust / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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97. Engelmark MT, Ivansson EL, Magnusson JJ, Gustavsson IM, Wyöni PI, Ingman M, Magnusson PK, Gyllensten UB: Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. Hum Genet; 2008 Jun;123(5):437-43
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

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  • [Title] Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis.
  • Cervical cancer is a multifactorial disease influenced by both environmental and genetic factors.
  • We have previously found linkage to 9q32 in a genomewide scan of affected sib-pairs (ASPs) with cervical cancer and to the thymic stromal co-transporter (TSCOT), a candidate gene in this region.
  • Here we examined the contribution of 9q32 and TSCOT to cervical cancer susceptibility using at larger material of 641 ASPs, 278 of which were included in the earlier genome-scan.
  • Since heritable forms of cancer frequently show stronger genetic effects in families with early onset of disease, we stratified the ASPs into two groups based on mean age at diagnosis (MAAD) within sib-pairs.
  • Surprisingly, ASPs with high MAAD (30.5-47.5 years) showed increased sharing at all microsatellite markers at 9q31.1-33.1 and linkage signals of up to MLS = 2.74 for TSCOT SNPs, while ASPs with low MAAD (19-30 years) showed no deviation from random genetic sharing (MLS = 0.00).
  • [MeSH-major] Chromosomes, Human, Pair 9 / genetics. Genetic Linkage / genetics. Polymorphism, Single Nucleotide / genetics. Siblings. Symporters / genetics. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Female. Genetic Predisposition to Disease / epidemiology. Genotype. Humans. Lod Score. Microsatellite Repeats / genetics. Middle Aged. Sweden / epidemiology

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  • (PMID = 18392855.001).
  • [ISSN] 1432-1203
  • [Journal-full-title] Human genetics
  • [ISO-abbreviation] Hum. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / SLC46A2 protein, human; 0 / Symporters
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98. Durlak JA, Mahoney JL, Bohnert AM, Parente ME: Developing and improving after-school programs to enhance youth's personal growth and adjustment: a special issue of AJCP. Am J Community Psychol; 2010 Jun;45(3-4):285-93
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Participating in after-school programs (ASPs) has become a common experience for children.
  • This special issue provides a perspective on the current status of research on ASPs.
  • This introductory article overviews the historical and current context of ASPs and then describes a developmental ecological model to guide research in this area.

  • MedlinePlus Health Information. consumer health - Child Development.
  • MedlinePlus Health Information. consumer health - Toddler Development.
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  • (PMID = 20358278.001).
  • [ISSN] 1573-2770
  • [Journal-full-title] American journal of community psychology
  • [ISO-abbreviation] Am J Community Psychol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Shih PY, Wang T, Xing C, Sinha M, Song Y, Elston RC: Linkage analysis of alcohol dependence using both affected and discordant sib pairs. BMC Genet; 2005 Dec 30;6 Suppl 1:S36
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The basic idea of affected-sib-pair (ASP) linkage analysis is to test whether the inheritance pattern of a marker deviates from Mendelian expectation in a sample of ASPs.
  • To be robust to deviation from Mendelian transmission, here we analyzed Collaborative Study on the Genetics of Alcoholism data by modifying the ASP LOD score method to contrast the estimated distribution of the number of allele(s) shared IBD by ASPs with that by DSPs, instead of with the expected distribution under the Mendelian assumption.
  • This strategy assesses the difference in IBD sharing between ASPs and the IBD sharing between DSPs.

  • Genetic Alliance. consumer health - Alcohol dependence.
  • MedlinePlus Health Information. consumer health - Alcoholism and Alcohol Abuse.
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  • (PMID = 16451646.001).
  • [ISSN] 1471-2156
  • [Journal-full-title] BMC genetics
  • [ISO-abbreviation] BMC Genet.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R37 GM028356; United States / NCRR NIH HHS / RR / P41 RR003655; United States / NIDDK NIH HHS / DK / DK-57292; United States / NCRR NIH HHS / RR / RR03655; United States / NIGMS NIH HHS / GM / GM28356; United States / NIDDK NIH HHS / DK / U01 DK057292; United States / NIGMS NIH HHS / GM / R01 GM028356
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC1866749
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100. Visser A, Van Zeveren AM, Meyvis Y, Peelaers I, Van den Broeck W, Gevaert K, Vercruysse J, Claerebout E, Geldhof P: Gender-enriched transcription of activation associated secreted proteins in Ostertagia ostertagi. Int J Parasitol; 2008 Mar;38(3-4):455-65

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Activation associated secreted proteins (ASP) are members of a nematode-specific protein family belonging to the SCP/Tpx-1/Ag5/PR-1/Sc7 family.
  • Three different types of molecules have been identified in this family: two-domain ASPs and single-domain ASPs showing homology to either the C-terminal or N-terminal domain of the two-domain ASP.
  • Here we report that the abomasal cattle parasite Ostertagia ostertagi produces at least 15 ASPs, including two-domain and C- and N-type single-domain ASPs.
  • The latter was especially the case for the N-type single-domain ASPs Oo-ASP1 and Oo-ASP2 and also for Oo-ASP3, which is homologous with the Haemonchus contortus and Ancylostoma caninum C-type single-domain ASPs.

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  • (PMID = 17961575.001).
  • [ISSN] 0020-7519
  • [Journal-full-title] International journal for parasitology
  • [ISO-abbreviation] Int. J. Parasitol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AM747038/ AM747039
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Helminth Proteins
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