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Items 1 to 33 of about 33
1. Kim YD, Lee CH, Lee MK, Jeong YJ, Kim JY, Park DY, Sol MY: Primary alveolar soft part sarcoma of the lung. J Korean Med Sci; 2007 Apr;22(2):369-72
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  • [Title] Primary alveolar soft part sarcoma of the lung.
  • Alveolar soft part sarcoma (ASPS) is a rare epithelial-like soft tissue sarcoma.
  • Primary pulmonary involvement of this sarcoma, without evidence of soft tissue tumor elsewhere, is very exceptional.
  • After 5 months, three metastatic lesions, involving lumbar vertebrae and occipital scalp, were found.
  • Histologically, the tumor consisted of alveolar nests of large polygonal tumor cells, the cytoplasm of which frequently revealed periodic acid-Schiff-positive, diastase-resistant intracytoplasmic rod-like structures.
  • [MeSH-major] Lung Neoplasms / pathology. Lung Neoplasms / radiography. Pulmonary Alveoli / pathology. Pulmonary Alveoli / radiography. Sarcoma / pathology. Sarcoma / radiography
  • [MeSH-minor] Adult. Female. Humans. Rare Diseases / pathology. Rare Diseases / radiography. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / radiography

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  • (PMID = 17449953.001).
  • [ISSN] 1011-8934
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2693611
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2. Lazar AJ, Das P, Tuvin D, Korchin B, Zhu Q, Jin Z, Warneke CL, Zhang PS, Hernandez V, Lopez-Terrada D, Pisters PW, Pollock RE, Lev D: Angiogenesis-promoting gene patterns in alveolar soft part sarcoma. Clin Cancer Res; 2007 Dec 15;13(24):7314-21
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  • [Title] Angiogenesis-promoting gene patterns in alveolar soft part sarcoma.
  • PURPOSE: We examined a cohort of patients with alveolar soft part sarcoma (ASPS) treated at our institution and showed the characteristic ASPSCR1-TFE3 fusion transcript in their tumors.
  • CONCLUSION: ASPS is a highly vascular and metastatic tumor with a surprisingly favorable outcome; therapeutically resistant metastases drive mortality.
  • [MeSH-major] Neovascularization, Pathologic / genetics. Sarcoma, Alveolar Soft Part / genetics

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  • (PMID = 18094412.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / TFE3 protein, human
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3. Stacchiotti S, Tamborini E, Marrari A, Brich S, Rota SA, Orsenigo M, Crippa F, Morosi C, Gronchi A, Pierotti MA, Casali PG, Pilotti S: Response to sunitinib malate in advanced alveolar soft part sarcoma. Clin Cancer Res; 2009 Feb 1;15(3):1096-104
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  • [Title] Response to sunitinib malate in advanced alveolar soft part sarcoma.
  • PURPOSE: Alveolar soft part sarcoma (ASPS) is a rare, chemoresistant soft tissue sarcoma.
  • EXPERIMENTAL DESIGN: Since July 2007, five patients with progressive metastatic ASPS have been treated with continuous SM 37.5 mg/d on a named basis.
  • [MeSH-major] Indoles / therapeutic use. Protein Kinase Inhibitors / therapeutic use. Pyrroles / therapeutic use. Sarcoma, Alveolar Soft Part / drug therapy

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  • (PMID = 19188185.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indoles; 0 / Protein Kinase Inhibitors; 0 / Pyrroles; 0 / sunitinib; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor; EC 2.7.10.1 / Receptors, Vascular Endothelial Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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4. Anderson ME, Hornicek FJ, Gebhardt MC, Raskin KA, Mankin HJ: Alveolar soft part sarcoma: a rare and enigmatic entity. Clin Orthop Relat Res; 2005 Sep;438:144-8
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  • [Title] Alveolar soft part sarcoma: a rare and enigmatic entity.
  • Alveolar soft part sarcoma is a rare malignant tumor with unusual clinical behavior.
  • Treatment of alveolar soft part sarcoma has been difficult to evaluate because of the small numbers of cases seen, but it seemed that although treatment of the primary tumor in alveolar soft part sarcoma often is successful, treatment of metastatic tumors is unsuccessful.
  • A review of outcome after treatment of primary and metastatic disease in the 15 patients in our database with alveolar soft part sarcoma was done in order to evaluate this issue.
  • Nine of 15 patients presented with metastatic disease and one further patient developed metastases.
  • Adjuvant chemotherapy was administered to one patient with localized disease and to six patients with metastatic disease.
  • Treatment of metastatic tumors involved chemotherapy in seven patients, metastectomy in three patients, and radiation in two patients.
  • All instances of the metastatic disease either recurred or progressed.
  • Overall survival was 75% at 5 years and 40% at 10 years with a mean survival of 6.5 years, despite the high number of patients with metastatic disease.
  • Current treatment results in good local control of primary tumors, but poor control of metastatic tumors.
  • New approaches to treatment of metastatic alveolar soft part sarcoma must be investigated and applied.
  • [MeSH-major] Neoplasm Metastasis / pathology. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 16131883.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; NR7O1405Q9 / Mesna; UM20QQM95Y / Ifosfamide; MAID protocol
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5. Daigeler A, Kuhnen C, Hauser J, Goertz O, Tilkorn D, Steinstraesser L, Steinau HU, Lehnhardt M: Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases. World J Surg Oncol; 2008;6:71
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  • [Title] Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases.
  • BACKGROUND: Alveolar sarcoma of the soft parts (ASPS) represents a very rare entity of soft tissue sarcoma with special features such as young peak age incidence and frequent metastasis to the brain.
  • METHODS: From the database of the BG-University Hospital Bergmannsheil, 1597 soft tissue sarcoma (STS) cases were reviewed and 11 consecutive patients with ASPS were isolated.
  • RESULTS: Patients with localized disease who received complete resection and adjuvant radiation and who did not develop recurrence or metastatic disease within 2 years after surgery had a positive outcome.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / therapy

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  • (PMID = 18593459.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
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  • [Other-IDs] NLM/ PMC2459182
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6. Madrigrano A, Beach B, Wheeler A, Wapnir I: Metastases to the breast: alveolar soft part sarcoma in adolescents. Clin Breast Cancer; 2008 Feb;8(1):92-3
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  • [Title] Metastases to the breast: alveolar soft part sarcoma in adolescents.
  • This is a case report of an 18-year-old woman with an alveolar soft part sarcoma metastatic to the breast.
  • [MeSH-major] Breast Neoplasms / secondary. Sarcoma, Alveolar Soft Part / secondary. Skin Neoplasms / pathology


7. Stockwin LH, Vistica DT, Kenney S, Schrump DS, Butcher DO, Raffeld M, Shoemaker RH: Gene expression profiling of alveolar soft-part sarcoma (ASPS). BMC Cancer; 2009 Jan 15;9:22
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  • [Title] Gene expression profiling of alveolar soft-part sarcoma (ASPS).
  • BACKGROUND: Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft tissue sarcoma affecting predominantly adolescents and young adults.
  • METHODS: For seven patients with confirmed primary or metastatic ASPS, RNA samples were isolated immediately following surgery, reverse transcribed to cDNA and each sample hybridized to duplicate high-density human U133 plus 2.0 microarrays.

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  • (PMID = 19146682.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Validation Studies
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2635365
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8. Hanzer M, Nebl A, Spendel S, Pilhatsch A, Urban C, Benesch M: Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh. Klin Padiatr; 2010 May;222(3):184-6
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  • [Title] Necrosis of a skin autograft after short-term treatment with sunitinib in a 14-year-old girl with metastatic alveolar soft part sarcoma of the thigh.
  • A 14-year-old girl was diagnosed with alveolar soft part sarcoma (ASPS) of the thigh and lung metastases.
  • [MeSH-major] Angiogenesis Inhibitors / adverse effects. Antineoplastic Agents / adverse effects. Indoles / adverse effects. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Pyrroles / adverse effects. Sarcoma, Alveolar Soft Part / drug therapy. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / drug therapy. Surgical Flaps / blood supply. Surgical Flaps / pathology. Thigh

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  • (PMID = 20514624.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib
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9. Lee GW, Kim TH, Min HJ, Kim HJ, Jung WT, Lee OJ, Ko GH: Unusual gastrointestinal metastases from an alveolar soft part sarcoma. Dig Endosc; 2010 Apr;22(2):137-9
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  • [Title] Unusual gastrointestinal metastases from an alveolar soft part sarcoma.
  • Alveolar soft part sarcoma (ASPS) is a rare subtype of soft tissue sarcoma that occurs predominantly in young patients.
  • The common metastatic sites from an ASPS include the lung, brain and bone.
  • [MeSH-major] Jejunal Neoplasms / secondary. Sarcoma, Alveolar Soft Part / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 20447209.001).
  • [ISSN] 1443-1661
  • [Journal-full-title] Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • [ISO-abbreviation] Dig Endosc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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10. Bodi I, Gonzalez D, Epaliyange P, Gullan R, Fisher C: Meningeal alveolar soft part sarcoma confirmed by characteristic ASPCR1-TFE3 fusion. Neuropathology; 2009 Aug;29(4):460-5
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  • [Title] Meningeal alveolar soft part sarcoma confirmed by characteristic ASPCR1-TFE3 fusion.
  • Sarcoma metastatic to the brain is uncommon and rarely occurs as the initial manifestation of tumor.
  • Alveolar soft part sarcoma (ASPS) is a rare but well-studied subtype of sarcoma.
  • ASPS typically arise from the soft tissues of the extremities and develop multiple metastatic deposits usually with a long clinical course.
  • This case may represent primary meningeal ASPS although metastatic deposit from an undiscovered primary site cannot be entirely excluded.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Biomarkers, Tumor / genetics. Gene Fusion / genetics. Meningeal Neoplasms / genetics. Sarcoma, Alveolar Soft Part / genetics

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  • (PMID = 18713311.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / TFE3 protein, human
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11. Guntupalli S, Anderson ML, Bodurka DC: Alveolar soft part sarcoma of the cervix: case report and literature review. Arch Gynecol Obstet; 2009 Feb;279(2):263-5
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  • [Title] Alveolar soft part sarcoma of the cervix: case report and literature review.
  • Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy typically found in the extremities or chest of young adults.
  • We present a case of an alveolar soft part sarcoma arising in the endocervix of a 38-year-old premenopausal woman.
  • No evidence of metastatic disease was found after extensive surgical staging.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / diagnosis. Uterine Cervical Neoplasms / diagnosis


12. Kasashima S, Minato H, Kobayashi M, Ueda Y, Oda Y, Hashimoto S, Inoue M: Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors. APMIS; 2007 Jul;115(7):861-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the endometrium with expression of CD10 and hormone receptors.
  • Alveolar soft part sarcoma (ASPS) is a rare tumor of uncertain histogenesis, mainly localized in the extremities.
  • Metastatic malignant tumor, including ASPS from other organs, was excluded by physical examination and imaging modalities.
  • The tumor showed characteristic histological features of ASPS: alveolar architecture with fibrovascular septa and abundant eosinophilic granular cytoplasm with periodic acid-Schiff-positive crystalline material.
  • [MeSH-major] Endometrial Neoplasms / diagnosis. Neprilysin / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Sarcoma, Alveolar Soft Part / diagnosis

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  • (PMID = 17614855.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 0 / TFE3 protein, human; EC 3.4.24.11 / Neprilysin
  • [Number-of-references] 15
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13. Gardner K, Judson I, Leahy M, Barquin E, Marotti M, Collins B, Young H, Scurr M: Activity of cediranib, a highly potent and selective VEGF signaling inhibitor, in alveolar soft part sarcoma. J Clin Oncol; 2009 May 20;27(15_suppl):10523

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activity of cediranib, a highly potent and selective VEGF signaling inhibitor, in alveolar soft part sarcoma.
  • : 10523 Background: Alveolar soft part sarcoma (ASPS) is a rare entity making up <1% of soft tissue sarcomas (STS).
  • It is typically indolent but with a high incidence of metastatic disease, usually to lungs, but also to sites such as the brain.

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  • (PMID = 27963912.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Benetos IS, Mavrogenis AF, Soultanis KCh, Zoubos AB, Papagelopoulos PJ, Soucacos PN: Alveolar soft part sarcoma of the forearm: a case report. J Surg Orthop Adv; 2006;15(4):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma of the forearm: a case report.
  • Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma that most commonly arises in the deep soft tissues of the lower extremities of adults.
  • Median survival of patients with metastatic ASPS has been reported to be from 3 to 3.3 years.
  • Chemotherapy was unsuccessfully used to control the metastatic disease.
  • This time to death after the development of metastases vastly exceeded the previously reported survival rates of patients with metastatic ASPS.
  • [MeSH-major] Forearm. Sarcoma, Alveolar Soft Part / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 17313933.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Kayton ML, Meyers P, Wexler LH, Gerald WL, LaQuaglia MP: Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults. J Pediatr Surg; 2006 Jan;41(1):187-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults.
  • PURPOSE: Alveolar soft part sarcoma is a rare soft tissue neoplasm that can affect children and adolescents.
  • To define the clinical presentation, treatment, and outcome of young people with this rare sarcoma, we reviewed our clinical experience.
  • METHODS: After institutional review board approval, we examined the records of all patients younger than 25 years old who received treatment at our institution for alveolar soft part sarcoma in the past 30 years.
  • Metastatic sites included lymph nodes, lung, and brain.
  • CONCLUSIONS: Achievement of complete microscopic resection is critical in localized alveolar soft part sarcoma, but incomplete excision and misdiagnosis are often encountered.
  • [MeSH-major] Sarcoma / pathology. Sarcoma / surgery


16. Eley KA, Afzal T, Shah KA, Watt-Smith SR: Alveolar soft-part sarcoma of the tongue: report of a case and review of the literature. Int J Oral Maxillofac Surg; 2010 Aug;39(8):824-6
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  • [Title] Alveolar soft-part sarcoma of the tongue: report of a case and review of the literature.
  • Alveolar soft part sarcoma (ASPS) accounts for less than 1% of all sarcomas.
  • Whilst rare, head and neck surgeons should be aware of ASPS as a potential cause of slow growing lesions, as early surgical resection is vital in view of the propensity for metastatic spread.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Tongue Neoplasms / pathology

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  • [Copyright] Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20335005.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
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17. Moyano S, Aguilera P, Petit A, de Alava E, Mascaró JM, Palou J, Ferrando J, Alos L: Alveolar soft part sarcoma presenting with cutaneous metastases: report of a case with immunohistochemical and molecular characterization. J Am Acad Dermatol; 2009 Jul;61(1):117-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma presenting with cutaneous metastases: report of a case with immunohistochemical and molecular characterization.
  • Alveolar soft part sarcoma (ASPS) is an uncommon neoplasm of uncertain histogenesis that usually behaves as a painless, slow-growing mass that metastasizes early.
  • We report a 21-year-old woman with cutaneous metastases of ASPS, whose histologic characteristics gave rise to a wide range of differential diagnoses of both primary and metastatic cutaneous neoplasms.
  • The molecular study identified a type 2 alveolar soft part locus-transcription factor E3 (ASPL-TFE3) fusion, secondary to der(17)t(X;17)(p11.2;q25) translocation.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / secondary. Skin Neoplasms / secondary

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  • (PMID = 19539846.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Rocha LA, Rizo VH, Romañach MJ, de Almeida OP, Vargas PA: Oral metastasis of alveolar soft-part sarcoma: a case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Apr;109(4):587-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral metastasis of alveolar soft-part sarcoma: a case report and review of literature.
  • Alveolar soft-part sarcoma (ASPS) is a rare malignant neoplasm with uncertain histogenesis and with a distinctive morphology.
  • An incisional biopsy was performed and the diagnosis of metastatic ASPS was made.
  • [MeSH-major] Gingival Neoplasms / secondary. Maxilla / pathology. Sarcoma, Alveolar Soft Part / secondary

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20303057.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Lim HS, Heo SH, Park JG, Kang HK: Metastatic alveolar soft part sarcoma of the breast. J Ultrasound Med; 2006 Jul;25(7):929-32
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  • [Title] Metastatic alveolar soft part sarcoma of the breast.
  • [MeSH-major] Breast Neoplasms / secondary. Sarcoma / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 16798907.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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20. Wang ZH, Shi HY, Wang ZB: [Metastatic alveolar soft tissue sarcoma of the central nervous system: a clinicopathological analysis of four cases]. Ai Zheng; 2009 Nov;28(11):1214-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Metastatic alveolar soft tissue sarcoma of the central nervous system: a clinicopathological analysis of four cases].
  • BACKGROUND AND OBJECTIVE: Metastatic alveolar soft tissue sarcoma (ASTS) of the central nervous system is rare and is easy to be misdiagnosed as other primary tumors of central nervous system.
  • The metastatic lesions were located in the posterior cranial fossa, closely associated with the meninges.
  • The tumor cells had clear or eosinophilic cytoplasm and prominent nucleoli, arranged in alveolar structures, which were surrounded by delicate blood sinuses.
  • CONCLUSION: ASTS of the central nervous system was mostly metastatic and should be differentiated from other CNS tumors such as meningioma, melonocytic tumor, rhabdomyosarcoma and paraganglioma.
  • Metastatic ASTS of the central nervous system had poor prognosis and the five-year survival rate was low.
  • [MeSH-major] Cranial Fossa, Posterior. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / secondary. Skull Base Neoplasms / pathology. Skull Base Neoplasms / secondary

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  • (PMID = 19895745.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / S100 Proteins
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21. Rekhi B, Kumar R, Menon S, Medhi S, Desai SB: Calvarial metastasis of a renal cell carcinoma, mimicking a primary alveolar soft part sarcoma, in a young girl-a rare case report. Pathol Oncol Res; 2009 Mar;15(1):137-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Calvarial metastasis of a renal cell carcinoma, mimicking a primary alveolar soft part sarcoma, in a young girl-a rare case report.
  • We present a rare case of a disseminated RCC in a 15-year-old girl, who primarily presented with an occipital soft tissue mass.
  • Computed tomography (CT) of the head revealed a soft tissue mass in the scalp, eroding the occipital bone and extending intracranially.
  • Biopsy examination showed overlapping features of an alveolar soft part sarcoma (ASPS) and a RCC.
  • Diagnosis of a metastatic RCC was ascertained.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Sarcoma, Alveolar Soft Part / diagnostic imaging. Skull Neoplasms / secondary


22. Pennacchioli E, Fiore M, Collini P, Radaelli S, Dileo P, Stacchiotti S, Casali PG, Gronchi A: Alveolar soft part sarcoma: clinical presentation, treatment, and outcome in a series of 33 patients at a single institution. Ann Surg Oncol; 2010 Dec;17(12):3229-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alveolar soft part sarcoma: clinical presentation, treatment, and outcome in a series of 33 patients at a single institution.
  • BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare soft tissue tumor that usually affects young patients.
  • A comprehensive retrospective review was performed of clinical presentation, treatment, outcome, and patterns of failure in a consecutive series of patients with localized or metastatic ASPS between 1975 and 2008.
  • Metastatic sites included lymph nodes, lung, bone, and liver.
  • Metastectomies were performed in 33% of metastatic cases (7 of 21 patients).
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / therapy

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  • (PMID = 20593242.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Luo J, Melnick S, Rossi A, Burke RP, Pfeifer JD, Dehner LP: Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration. Pediatr Dev Pathol; 2008 Mar-Apr;11(2):142-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cardiac alveolar soft part sarcoma. A report of the first observed case with molecular diagnostics corroboration.
  • A case of primary alveolar soft part sarcoma (ASPS) of the heart is reported in an 11-year-old female as 1 of 16 cases of ASPS presenting in the first 2 decades of life in our institutional 17-year review period.
  • The classic alveolar or organoid pattern was inconspicuous as compared to a more diffuse or formless pattern consisting of a population of uniform round cells with abundant eosinophilic cytoplasm, but in addition there was a second, minor population of gigantiform tumor cells with a variety of unusual shapes.
  • The only other examples of ASPS involving the heart were 3 cases in the literature of metastatic disease from tumors arising in the soft tissues.
  • [MeSH-major] Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics. Heart Neoplasms / pathology. Neoplasm Proteins / genetics. Oncogene Proteins, Fusion / genetics. Sarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17378669.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ASPSCR1 protein, human; 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Neoplasm; 0 / TFE3 protein, human
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24. Carter JE, Evans TN, Tucker JA: Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report. Acta Cytol; 2008 Jul-Aug;52(4):459-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytologic diagnosis of alveolar soft part sarcoma of the lower extremity by fine needle aspiration and correlation with core biopsy: a case report.
  • BACKGROUND: Alveolar soft part sarcoma is a rare soft tissue tumor of uncertain origin that is generally slow growing but unmistakably malignant due to its propensity for metastasis to lung, bone and brain early in the course of disease.
  • Imaging studies revealed a left leg soft tissue mass just below the popliteal fossa and multiple bilateral lung lesions suggestive of metastatic neoplasm.
  • A periodic acid-Schiff (PAS) stain highlighted intracytoplasmic rhomboidal crystals, a feature diagnostic of alveolar soft part sarcoma.
  • CONCLUSION: Alveolar soft part sarcoma may be diagnosed by its unique morphologic characteristics and should be considered in the differential diagnosis of all cytologically sampled soft tissue lesions.
  • [MeSH-major] Sarcoma, Alveolar Soft Part / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18702365.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Fox BD, Patel A, Suki D, Rao G: Surgical management of metastatic sarcoma to the brain. J Neurosurg; 2009 Jan;110(1):181-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of metastatic sarcoma to the brain.
  • OBJECT: Metastatic sarcoma to the brain is rare and represents a therapeutic challenge due to its relative resistance to radio- and chemotherapy.
  • The authors reviewed a series of patients with metastatic sarcoma to the brain treated surgically to determine outcomes and identify predictors of survival in these patients.
  • METHODS: A retrospective review of prospectively collected data was undertaken on patients undergoing surgery between 1993 and 2005 for metastatic sarcoma to the brain at The University of Texas, M.D.
  • RESULTS: During the study period, 62 patients underwent 84 operations for metastatic sarcoma to the brain.
  • In multivariate and univariate analysis, control of systemic disease, and sarcomas originating from bone, cartilage, or soft tissue were predictors of survival.
  • In patients with alveolar soft-part sarcoma, there was a significantly increased survival advantage compared with all other histological subgroups.
  • CONCLUSIONS: The authors' results suggest that in selected patients, resection of metastatic sarcoma to the brain is associated with a relatively low risk of operative death and results in improvement in neurological function.
  • Patients with systemic control of their primary disease and certain histological subtypes (specifically alveolar soft-part sarcoma) have improved overall and progression-free survival.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / surgery. Neurosurgical Procedures. Sarcoma / secondary. Sarcoma / surgery


26. D'Angelo P, Carli M, Ferrari A, Manzitti C, Mura R, Miglionico L, Di Cataldo A, Grigoli A, Cecchetto G, Bisogno G, AIEOP Soft Tissue Sarcoma Committee: Breast metastases in children and adolescents with rhabdomyosarcoma: Experience of the Italian Soft Tissue Sarcoma Committee. Pediatr Blood Cancer; 2010 Dec 15;55(7):1306-9
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  • [Title] Breast metastases in children and adolescents with rhabdomyosarcoma: Experience of the Italian Soft Tissue Sarcoma Committee.
  • Aim of the study was to evaluate clinical characteristics, treatment, and subsequent outcome, of patients with RMS metastasis in the breast, enrolled in four consecutive Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP) Soft Tissue Sarcoma Committee protocols during the last 20 years, in order to obtain information to establish a more adequate diagnostic and therapeutic approach.
  • RESULTS: From 1988 to 2008, among 189 patients with metastatic RMS, we identified 7 (3.7%) patients with RMS with breast involvement at diagnosis.
  • All patients were females, aged 13-17 years with alveolar histology and multiple metastasis sites (2-5).
  • CONCLUSIONS: Our data suggest that investigations of the mammary region should be part of the usual diagnostic workup in adolescent girls with alveolar RMS, especially if the primary tumor arises in the extremities.

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • (PMID = 20730885.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Salvati M, D'Elia A, Frati A, Santoro A: Sarcoma metastatic to the brain: a series of 35 cases and considerations from 27 years of experience. J Neurooncol; 2010 Jul;98(3):373-7
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  • [Title] Sarcoma metastatic to the brain: a series of 35 cases and considerations from 27 years of experience.
  • The authors report their 27-year experience regarding 35 cases of supratentorial brain metastasis from sarcoma treated in a single institution: these included ten osteosarcomas, seven leiomyosarcomas, five Ewing sarcomas, four malignant fibrous histiocytomas, three alveolar soft-part sarcomas (ASPS), two rhabdomyosarcomas, one liposarcoma, and three unclassified sarcomas.
  • The authors conclude that surgery is more effective in treating selected patients with sarcoma metastatic to the brain, and that patients with metastasis from ASPS have good prognosis when submitted to surgical treatment.
  • Finally, it seems that surgical indications for multiple brain metastases from sarcoma have increased during the last ten years.
  • [MeSH-major] Brain Neoplasms / secondary. Brain Neoplasms / therapy. Cranial Irradiation / methods. Sarcoma / pathology

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  • (PMID = 20039192.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Azizi AA, Haberler C, Czech T, Gupper A, Prayer D, Breitschopf H, Acker T, Slavc I: Vascular-endothelial-growth-factor (VEGF) expression and possible response to angiogenesis inhibitor bevacizumab in metastatic alveolar soft part sarcoma. Lancet Oncol; 2006 Jun;7(6):521-3
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  • [Title] Vascular-endothelial-growth-factor (VEGF) expression and possible response to angiogenesis inhibitor bevacizumab in metastatic alveolar soft part sarcoma.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antibodies, Monoclonal / therapeutic use. Brain Neoplasms / drug therapy. Brain Neoplasms / secondary. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Muscle Neoplasms / drug therapy. Psoas Muscles. Sarcoma, Alveolar Soft Part / drug therapy. Vascular Endothelial Growth Factor A / metabolism

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  • [ErratumIn] Lancet Oncol. 2006 Jul;7(7):533
  • (PMID = 16750504.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / RNA, Messenger; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab
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29. Cecchetto G, Alaggio R, Dall'Igna P, Bisogno G, Ferrari A, Gigante C, Casanova M, Sotti G, Zanetti I, Carli M: Localized unresectable non-rhabdo soft tissue sarcomas of the extremities in pediatric age: results from the Italian studies. Cancer; 2005 Nov 1;104(9):2006-12
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  • [Title] Localized unresectable non-rhabdo soft tissue sarcomas of the extremities in pediatric age: results from the Italian studies.
  • BACKGROUND: Treatment of initially unresectable nonrhabdo soft tissue sarcomas (NRSTS) in pediatric age is debated, due to their different chemosensitivity.
  • Chemosensitive (CTs) sarcomas, 21: synovial sarcoma, 11; extraosseous Ewing sarcomas, 5; primitive peripheral neuroectodermic tumors, 5.
  • Nonchemosensitive (CTns) sarcomas, 31: fibrosarcoma, 11; malignant peripheral nerve sheet tumors, 10; liposarcoma, 2; hemangiopericitoma adult type, 2; epithelioid sarcoma, 2; and alveolar soft part sarcoma, leiomyosarcoma, clear cell sarcoma, and sarcoma NOS, each 1.
  • Relapses were cured in several cases of CTs tumors, whereas almost all patients with relapsed CTns tumors died due to the high rate of metastatic spread.
  • [MeSH-major] Extremities. Sarcoma / diagnosis

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 16161038.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Kayton ML: Pulmonary metastasectomy in pediatric patients. Thorac Surg Clin; 2006 May;16(2):167-83, vi
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Because many pediatric metastatic tumors are rare, surgeons have grouped together patients of different histologies for the generation and analysis of case series.
  • By examining tumor types individually, however, it is seen that certain histologies (adrenocortical carcinoma, alveolar soft part sarcoma, osteosarcoma) mandate surgical metastasectomy for patient survival.
  • Other pediatric tumors (Wilms tumor, Ewing's sarcoma) are radiation sensitive, and the application of metastasectomy is controversial.
  • [MeSH-minor] Biopsy. Child. Humans. Infant. Minimally Invasive Surgical Procedures. Neoplasms, Complex and Mixed / diagnosis. Neoplasms, Complex and Mixed / secondary. Neoplasms, Complex and Mixed / surgery. Neoplasms, Glandular and Epithelial / diagnosis. Neoplasms, Glandular and Epithelial / secondary. Neoplasms, Glandular and Epithelial / surgery. Pulmonary Surgical Procedures. Sarcoma / diagnosis. Sarcoma / secondary. Sarcoma / surgery

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  • (PMID = 16805206.001).
  • [ISSN] 1547-4127
  • [Journal-full-title] Thoracic surgery clinics
  • [ISO-abbreviation] Thorac Surg Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 91
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31. Kebudi R, Ayan I, Görgün O, Ağaoğlu FY, Vural S, Darendeliler E: Brain metastasis in pediatric extracranial solid tumors: survey and literature review. J Neurooncol; 2005 Jan;71(1):43-8
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  • The diagnosis was sarcomas in 12 patients: 5 osteosarcomas, 4 Ewing's sarcoma family tumors, 1 rhabdomyosarcoma, 1 clear cell sarcoma of the soft tissue, 1 alveolar soft part sarcoma.
  • Only one patient with alveolar soft part sarcoma is alive with disease 20 months from diagnosis of brain metastasis.
  • CONCLUSIONS: Children with metastatic cancer who develop headaches or any other neurologic symptom should be investigated for possible brain metastasis.
  • Although, the outcome for these patients is dismal in this series and in the literature; reports of long term survival in a few cases with Wilms' tumor, osteosarcoma and alveolar soft part sarcoma who had isolated brain metastasis, suggest that a subset of patients may benefit from therapy.
  • [MeSH-major] Brain Neoplasms / epidemiology. Brain Neoplasms / secondary. Sarcoma / epidemiology. Sarcoma / secondary

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  • (PMID = 15719274.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 43
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32. Flannery T, Kano H, Niranjan A, Monaco EA 3rd, Flickinger JC, Kofler J, Lunsford LD, Kondziolka D: Gamma knife radiosurgery as a therapeutic strategy for intracranial sarcomatous metastases. Int J Radiat Oncol Biol Phys; 2010 Feb 1;76(2):513-9
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  • The primary pathology was metastatic leiomyosarcoma (4 patients), osteosarcoma (3 patients), soft-tissue sarcoma (5 patients), chondrosarcoma (2 patients), alveolar soft part sarcoma (2 patients), and rhabdomyosarcoma, Ewing's sarcoma, liposarcoma, neurofibrosarcoma, and synovial sarcoma (1 patient each).
  • [MeSH-major] Brain Neoplasms / surgery. Radiosurgery. Sarcoma / surgery

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 19467792.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. Lin YY, Hsieh TC, Kao CH, Wang CH, Wu YC, Yen KY, Sun SS: Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma. Clin Nucl Med; 2009 Nov;34(11):806-7
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  • [Title] Bone scintigraphic images of a patient with unusual metastatic alveolar soft-part sarcoma.
  • [MeSH-major] Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Sarcoma, Alveolar Soft Part / pathology. Sarcoma, Alveolar Soft Part / radionuclide imaging. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / radionuclide imaging

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  • (PMID = 19851182.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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