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1. Taylor A, Wang D, Patel K, Whittall R, Wood G, Farrer M, Neely RD, Fairgrieve S, Nair D, Barbir M, Jones JL, Egan S, Everdale R, Lolin Y, Hughes E, Cooper JA, Hadfield SG, Norbury G, Humphries SE: Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project. Clin Genet; 2010 Jun;77(6):572-80
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  • [Title] Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project.
  • Cascade testing using DNA-mutation information is now recommended in the UK for patients with familial hypercholesterolaemia (FH).
  • We compared the detection rate and mutation spectrum in FH patients with a clinical diagnosis of definite (DFH) and possible (PFH) FH.
  • Six hundred and thirty-five probands from six UK centres were tested for 18 low-density lipoprotein receptor gene (LDLR) mutations, APOB p.Arg3527Gln and PCSK9 p.Asp374Tyr using a commercial amplification refractory mutation system (ARMS) kit.
  • Samples with no mutation detected were screened in all exons by single strand conformation polymorphism analysis (SSCP)/denaturing high performance liquid chromatography electrophoresis (dHPLC)/direct-sequencing, followed by multiplex ligation-dependent probe amplification (MLPA) to detect deletions and duplications in LDLR.The detection rate was significantly higher in the 190 DFH patients compared to the 394 PFH patients (56.3% and 28.4%, p > 0.00001).
  • The ARMS kit detected 100 (44%) and the MLPA kit 11 (4.7%).
  • Twenty-eight (12%) of the patients had the APOB p.Arg3527Gln and four (1.7%) had the PCSK9 p.Asp374Tyr mutation.
  • Of the 296 relatives tested from 100 families, a mutation was identified in 56.1%.
  • The utility of the ARMS kit was confirmed, but sequencing is still required in a comprehensive diagnostic service for FH.
  • Even in subjects with a low clinical suspicion of FH, and in those of Indian origin, mutation testing has an acceptable detection rate.
  • [MeSH-major] Hypercholesterolemia / genetics. Mutation

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  • (PMID = 20236128.001).
  • [ISSN] 1399-0004
  • [Journal-full-title] Clinical genetics
  • [ISO-abbreviation] Clin. Genet.
  • [Language] eng
  • [Grant] United Kingdom / British Heart Foundation / / RG/08/008/25291; United Kingdom / British Heart Foundation / / PG2008/015; United Kingdom / Department of Health / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Apolipoproteins B; 0 / Receptors, LDL
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2. Sutachan JJ, Chao MV, Ninan I: Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa. J Neurosci Res; 2010 Dec;88(16):3447-56
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  • [Title] Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin repeat-rich membrane spanning/kinase D-interacting substrate of 220 kDa.
  • The ankyrin repeat-rich membrane spanning (ARMS)/kinase D-interacting substrate of 220 kDa (Kidins220) scaffolding protein is expressed during the establishment of γ-aminobutyric acid (GABA) neurotransmission and is highly regulated by activity.
  • To evaluate whether ARMS/Kidins220 expression affects GABAergic neurotransmission, we modified the ARMS/Kidins220 levels during the period of its maximum expression in culture (DIV 1-10).
  • Whereas a decrease in ARMS/Kidins220 levels suppressed GABAergic neurotransmission, overexpression of ARMS/Kidins220 produced an increase in GABAergic neurotransmission in hippocampal neurons.
  • In addition, we found that ARMS/Kidins220 regulates GABAergic neurotransmission by a presynaptic mechanism.
  • Our results suggest that the ARMS/Kidins220 scaffold protein plays a critical role in the regulation of inhibitory transmission in hippocampal neurons.
  • [MeSH-major] Cytoskeletal Proteins / metabolism. Inhibitory Postsynaptic Potentials / physiology. Membrane Proteins / metabolism. Neurons / metabolism. Phosphoproteins / metabolism. gamma-Aminobutyric Acid / metabolism
  • [MeSH-minor] Animals. Ankyrin Repeat. Cells, Cultured. Gene Expression Regulation / physiology. Hippocampus / cytology. Hippocampus / metabolism. Rats. Rats, Sprague-Dawley. Receptors, GABA-A / metabolism. Synaptic Transmission / physiology

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • (PMID = 20936698.001).
  • [ISSN] 1097-4547
  • [Journal-full-title] Journal of neuroscience research
  • [ISO-abbreviation] J. Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / Kidins220 protein, rat; 0 / Membrane Proteins; 0 / Phosphoproteins; 0 / Receptors, GABA-A; 56-12-2 / gamma-Aminobutyric Acid
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3. Jain S, Xu R, Prieto VG, Lee P: Molecular classification of soft tissue sarcomas and its clinical applications. Int J Clin Exp Pathol; 2010;3(4):416-28
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  • Sarcomas are a heterogeneous group of tumors that are traditionally classified according to the morphology and type of tissue that they resemble, such as rhabdomyosarcoma, which resembles skeletal muscle.
  • These specific genetic alterations are an important adjunct to standard morphological and immunohistochemical diagnoses, and in some cases have a prognostic value, e. g., Ewing family tumors, synovial sarcoma, and alveolar rhabdomyosarcoma.
  • In addition, these studies may also serve as markers to detect minimal residual disease and can aid in staging or monitor the efficacy of therapy.

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  • (PMID = 20490332.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
  • [Other-IDs] NLM/ PMC2872748
  • [Keywords] NOTNLM ; Sarcomas / molecular classification / molecular genetics / soft tissue tumors / specific genetic translocation
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4. Legendre BW, Nelson BL: Alveolar rhabdomyosarcoma of the paranasal sinuses. Head Neck Pathol; 2008 Dec;2(4):302-4
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  • [Title] Alveolar rhabdomyosarcoma of the paranasal sinuses.
  • [MeSH-major] Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinuses / pathology. Rhabdomyosarcoma, Alveolar / diagnosis

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  • (PMID = 20614299.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807579
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5. Ganesan P, Thulkar S, Rajan A, Bakhshi S: Solid variant of alveolar rhabdomyosarcoma mimicking non-Hodgkin lymphoma: case report and review of literature. J Pediatr Hematol Oncol; 2008 Oct;30(10):772-4
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  • [Title] Solid variant of alveolar rhabdomyosarcoma mimicking non-Hodgkin lymphoma: case report and review of literature.
  • Alveolar rhabdomyosarcoma is a high-grade neoplasm, which forms about 30% of rhabdomyosarcomas.
  • A histopathologic diagnosis of solid variant of alveolar rhabdomyosarcoma was made.
  • The patient was treated with salvage chemotherapy but had progressive disease.
  • In addition, the importance of biopsy in the diagnosis of suspected lymphomas and the pitfalls of needle aspirations are briefly discussed.
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Rhabdomyosarcoma, Alveolar / diagnosis
  • [MeSH-minor] Adolescent. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diagnosis, Differential. Female. Humans. Leg. Muscle, Skeletal. Salvage Therapy


6. de Sèze M, Falgairolle M, Viel S, Assaiante C, Cazalets JR: Sequential activation of axial muscles during different forms of rhythmic behavior in man. Exp Brain Res; 2008 Feb;185(2):237-47
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  • Subjects performed several rhythmic behaviors: forward walking (FW), backward walking (BW), amble walking (where the subjects moved their arms in phase with the ipsilateral leg), walking on hands and knees (HK) and walking on hands with the knees on the edge of a treadmill (Hand).
  • In a final task, the subjects were standing and were asked to swing (Swing) only their arms as if they were walking.

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  • (PMID = 17940760.001).
  • [ISSN] 1432-1106
  • [Journal-full-title] Experimental brain research
  • [ISO-abbreviation] Exp Brain Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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7. Cattel L, Airoldi M, Delprino L, Passera R, Milla P, Pedani F: Pharmacokinetic evaluation of gemcitabine and 2',2'-difluorodeoxycytidine-5'-triphosphate after prolonged infusion in patients affected by different solid tumors. Ann Oncol; 2006 May;17 Suppl 5:v142-7
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  • RESULTS: Patients were randomly assigned to one of the four arms.
  • Gemcitabine triphosphate was determined in the four arms in white blood cells; for infusion times from 0.5 to 3 h there was a progressive enhancement of gemcitabine triphosphate levels.

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  • (PMID = 16807444.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0W860991D6 / Deoxycytidine; 110988-86-8 / 2',2'-difluorodeoxycytidine 5'-triphosphate; 65-47-4 / Cytidine Triphosphate; B76N6SBZ8R / gemcitabine
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8. Verheijen RH, Massuger LF, Benigno BB, Epenetos AA, Lopes A, Soper JT, Markowska J, Vyzula R, Jobling T, Stamp G, Spiegel G, Thurston D, Falke T, Lambert J, Seiden MV: Phase III trial of intraperitoneal therapy with yttrium-90-labeled HMFG1 murine monoclonal antibody in patients with epithelial ovarian cancer after a surgically defined complete remission. J Clin Oncol; 2006 Feb 1;24(4):571-8
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  • Cox proportional hazards analysis of survival demonstrated no difference between treatment arms.
  • No difference in time to relapse was observed between the two study arms.
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Humans. Infusions, Parenteral. Laparoscopy. Middle Aged. Proportional Hazards Models. Remission Induction. Second-Look Surgery. Treatment Failure. Yttrium Radioisotopes

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  • [CommentIn] J Clin Oncol. 2006 Jul 20;24(21):3511-2 [16849774.001]
  • [CommentIn] J Clin Oncol. 2006 Feb 1;24(4):537-9 [16446325.001]
  • (PMID = 16446329.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Yttrium Radioisotopes; 0 / pemtumomab
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9. Pflueger MO, Gschwandtner U, Stieglitz RD, Riecher-Rössler A: Neuropsychological deficits in individuals with an at risk mental state for psychosis - working memory as a potential trait marker. Schizophr Res; 2007 Dec;97(1-3):14-24
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  • [Title] Neuropsychological deficits in individuals with an at risk mental state for psychosis - working memory as a potential trait marker.
  • OBJECTIVE: To investigate the neuropsychological profile of individuals with an at risk mental state for psychosis (ARMS, N=60) compared to healthy controls (HC, N=51) and to identify those cognitive domains which discriminate best between groups.
  • A multivariate analysis of variance (MANOVA) comparing ARMS subjects with HC was conducted.
  • A stepwise logit regression procedure was performed in order to determine the subset of measures which best distinguish ARMS subjects from HC.
  • RESULTS: ARMS subjects revealed deficiencies in intelligence, executive functions, working memory and attention.
  • CONCLUSION: Individuals with an at risk mental state for psychosis already show impairment of neuropsychological functions prior to the onset of the first psychotic episode and can best be distinguished from healthy controls on the basis of working memory.
  • [MeSH-major] Cognition Disorders / diagnosis. Memory, Short-Term. Neuropsychological Tests / statistics & numerical data. Psychotic Disorders / diagnosis. Schizophrenia / diagnosis. Schizophrenic Psychology
  • [MeSH-minor] Adolescent. Adult. Attention. Disease Progression. Early Diagnosis. Female. Humans. Intelligence. Male. Multivariate Analysis. Problem Solving. Psychomotor Performance. Reaction Time. Risk Assessment

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  • (PMID = 17936587.001).
  • [ISSN] 0920-9964
  • [Journal-full-title] Schizophrenia research
  • [ISO-abbreviation] Schizophr. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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10. Li KK, Pang JC, Chung NY, Ng YL, Chan NH, Zhou L, Poon WS, Ng HK: EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q. Int J Cancer; 2007 Feb 15;120(4):947-50
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  • [Title] EMP3 overexpression is associated with oligodendroglial tumors retaining chromosome arms 1p and 19q.
  • The epithelial membrane protein 3 (EMP3) gene located on chromosome 19q13 has been implicated as a candidate tumor suppressor gene (TSG) in neuroblastomas and gliomas.
  • We first investigated the transcript level of EMP3 in a cohort of 57 OTs by quantitative real-time RT-PCR.
  • [MeSH-major] Brain Neoplasms / genetics. Chromosomes, Human, Pair 1 / genetics. Chromosomes, Human, Pair 19 / genetics. DNA Methylation. Membrane Glycoproteins / genetics. Oligodendroglioma / genetics

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  • (PMID = 17187361.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / EMP3 protein, human; 0 / Membrane Glycoproteins
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11. Danzmann RG, Davidson EA, Ferguson MM, Gharbi K, Koop BF, Hoyheim B, Lien S, Lubieniecki KP, Moghadam HK, Park J, Phillips RB, Davidson WS: Distribution of ancestral proto-Actinopterygian chromosome arms within the genomes of 4R-derivative salmonid fishes (Rainbow trout and Atlantic salmon). BMC Genomics; 2008;9:557
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  • [Title] Distribution of ancestral proto-Actinopterygian chromosome arms within the genomes of 4R-derivative salmonid fishes (Rainbow trout and Atlantic salmon).
  • CONCLUSION: Two chromosome arms in Danio rerio and Oryzias latipes (descendants of the 3R duplication) can, in most instances be related to at least 4 whole or partial chromosomal arms in the salmonid species.

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  • (PMID = 19032764.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Transposable Elements
  • [Other-IDs] NLM/ PMC2632648
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12. Al Habeeb A, Partington S, Rosenthal D, Salama S: Skin thickening in a hemodialysis patient: a case of nephrogenic fibrosing dermopathy. J Cutan Med Surg; 2009 Mar-Apr;13(2):110-4
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  • CASE REPORT: A 71-year-old woman with hypertensive vasculopathy and renal failure, hypothyroidism, deep vein thrombosis, and a previous abdominal aneurysm repair presented with the rapid development of indurated skin over her arms and legs.
  • Interestingly, this patient had a history of vein thrombosis and vascular surgery, emphasizing the possible role these features may play as instigators of fibrosis in this disease.
  • [MeSH-minor] Aged. Aortic Aneurysm, Abdominal / epidemiology. Comorbidity. Diagnosis, Differential. Female. Humans. Hypothyroidism / epidemiology. Renal Dialysis. Skin / pathology. Venous Thrombosis / epidemiology

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  • (PMID = 19298781.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Janczak J, Perpétuo GJ: Hydrogen-bonded networks in crystals of 1-(diaminomethylene)thiouron-1-ium perchlorate, hydrogen sulfate, dihydrogen phosphate and dihydrogen arsenate. Acta Crystallogr C; 2008 Jun;64(Pt 6):o330-4
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  • Both arms of the cation are planar, but they are twisted with respect to one another around the central N atom.

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  • (PMID = 18535342.001).
  • [ISSN] 1600-5759
  • [Journal-full-title] Acta crystallographica. Section C, Crystal structure communications
  • [ISO-abbreviation] Acta Crystallogr C
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Arsenates; 0 / Inorganic Chemicals; 0 / Perchlorates; 0 / Phosphates; 0 / Sulfates; GYV9AM2QAG / Thiourea; N7CIZ75ZPN / arsenic acid; VLA4NZX2P4 / perchlorate
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14. Lalonde R, Barraud H, Ravey J, Guéant JL, Bronowicki JP, Strazielle C: Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice. Brain Res; 2008 Jan 10;1188:122-31
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  • Relative to either control group, vitamin-B-deficient mice were more active in the open field and in enclosed arms of the elevated plus-maze.
  • [MeSH-minor] Age Factors. Aging / physiology. Animals. Body Weight / physiology. Disease Models, Animal. Drinking / physiology. Eating / physiology. Exploratory Behavior / physiology. Female. Folic Acid Deficiency / complications. Folic Acid Deficiency / metabolism. Folic Acid Deficiency / physiopathology. Homocysteine / blood. Hyperhomocysteinemia / etiology. Hyperhomocysteinemia / metabolism. Hyperhomocysteinemia / physiopathology. Male. Memory Disorders / etiology. Memory Disorders / metabolism. Memory Disorders / physiopathology. Mice. Movement / physiology. Movement Disorders / etiology. Movement Disorders / metabolism. Movement Disorders / physiopathology. Space Perception / physiology. Vitamin B 12 Deficiency / complications. Vitamin B 12 Deficiency / metabolism. Vitamin B 12 Deficiency / physiopathology

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  • (PMID = 18061153.001).
  • [ISSN] 0006-8993
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0LVT1QZ0BA / Homocysteine
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15. Netto EM, Takahashi D, de Fátima Paim de Oliveira M, Barbosa P, Ferraz N, Paixão A, Oyafuso LK, Bortoletto C, Matos D, Paixão M, da Silva AO, Badaro R: Phase II randomized, placebo-controlled trial of M. vaccae-derived protein (PVAC) for the treatment of psoriasis. Vaccine; 2006 Jun 5;24(23):5056-63
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  • One hundred and sixty-five patients were enrolled in three arms (50 or 15 microg or placebo), each receiving a total of two intradermal injections (days 0 and 21).

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  • (PMID = 16621200.001).
  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Bacterial Vaccines; 0 / Placebos; 0 / Vaccines, Inactivated
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16. Tarricone R, Aguzzi G, Musi F, Fariselli L, Casasco A: Cost-effectiveness analysis for trigeminal neuralgia: Cyberknife vs microvascular decompression. Neuropsychiatr Dis Treat; 2008 Jun;4(3):647-52
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  • RESULTS: 20 patients for both arms were enrolled, for a total of 40 patients.

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  • (PMID = 18830392.001).
  • [ISSN] 1176-6328
  • [Journal-full-title] Neuropsychiatric disease and treatment
  • [ISO-abbreviation] Neuropsychiatr Dis Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC2526367
  • [Keywords] NOTNLM ; Cyberknife / cost-effectiveness analysis / decision-making / microvascular decompression / trigeminal neuralgia
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17. Benazzi F, Berk M, Frye MA, Wang W, Barraco A, Tohen M: Olanzapine/fluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis. J Clin Psychiatry; 2009 Oct;70(10):1424-31
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  • [Title] Olanzapine/fluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis.
  • A higher number of baseline concurrent manic/hypomanic symptoms predicted a lower response rate in the olanzapine and placebo arms, but not in the OFC arm.
  • The rates of dropouts in patients with mixed depression versus patients with nonmixed depression were not significantly different within any of the treatment arms.
  • [MeSH-major] Antidepressive Agents, Second-Generation / therapeutic use. Antipsychotic Agents / therapeutic use. Benzodiazepines / therapeutic use. Bipolar Disorder / drug therapy. Depressive Disorder, Major / drug therapy. Fluoxetine / therapeutic use. Risperidone / therapeutic use

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  • [Copyright] Copyright 2009 Physicians Postgraduate Press, Inc.
  • (PMID = 19906346.001).
  • [ISSN] 1555-2101
  • [Journal-full-title] The Journal of clinical psychiatry
  • [ISO-abbreviation] J Clin Psychiatry
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antidepressive Agents, Second-Generation; 0 / Antipsychotic Agents; 0 / Placebos; 01K63SUP8D / Fluoxetine; 12794-10-4 / Benzodiazepines; 132539-06-1 / olanzapine; L6UH7ZF8HC / Risperidone
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18. Hou R, Cao B, Chen Z, Li Y, Ning T, Li C, Xu C, Chen Z: Association of cytotoxic T lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer. Mol Biol Rep; 2010 Jan;37(1):515-20
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  • In this study we investigated the polymorphisms which would impact the CTLA-4 gene expression and function to assess the association with the risk of gastric cancer.
  • The promoter -1772T/C polymorphism was detected by PCR amplification refractory mutation system (ARMS) technique.
  • Our findings implied the genetic variations within CTLA-4 gene would be a critical risk factor to the susceptibility of gastric cancer.
  • [MeSH-major] Antigens, CD / genetics. Genetic Predisposition to Disease. Haplotypes / genetics. Stomach Neoplasms / genetics

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  • (PMID = 19688278.001).
  • [ISSN] 1573-4978
  • [Journal-full-title] Molecular biology reports
  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CTLA-4 Antigen; 0 / CTLA4 protein, human
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19. Johnson R, Jordaan AM, Pretorius L, Engelke E, van der Spuy G, Kewley C, Bosman M, van Helden PD, Warren R, Victor TC: Ethambutol resistance testing by mutation detection. Int J Tuberc Lung Dis; 2006 Jan;10(1):68-73
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  • [Title] Ethambutol resistance testing by mutation detection.
  • A newly developed one-step amplification refractory mutation system polymerase chain reaction (ARMS-PCR) method correctly detected the EMB-resistant genotype.
  • CONCLUSION: Implementation of more accurate diagnosis of EMB resistance may enhance patient management in South Africa, as standardised treatment of MDR-TB with second-line drugs is currently dependent on the outcome of the EMB resistance test.
  • [MeSH-major] Antitubercular Agents / pharmacology. Drug Resistance, Bacterial. Ethambutol / pharmacology. Mutation. Mycobacterium tuberculosis / drug effects. Mycobacterium tuberculosis / genetics

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  • (PMID = 16466040.001).
  • [ISSN] 1027-3719
  • [Journal-full-title] The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • [ISO-abbreviation] Int. J. Tuberc. Lung Dis.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R21 AI55800-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antitubercular Agents; 8G167061QZ / Ethambutol
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20. Nagy Z, Karádi O, Rumi G, Rumi G Jr, Pár A, Mózsik G, Czirják L, Süto G: Crohn's disease is associated with polymorphism of CARD15/NOD2 gene in a Hungarian population. Ann N Y Acad Sci; 2005 Jun;1051:45-51
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  • [Title] Crohn's disease is associated with polymorphism of CARD15/NOD2 gene in a Hungarian population.
  • Crohn's disease (CD) is commonly classified as an immune-mediated disorder, but genetic and environmental factors seem to be important in its pathogenesis.
  • The genotyping of the three common CARD15/NOD2 mutations (Arg702Trp, Gly908Arg, and Leu1007fsinsC) was carried out by restriction fragment length polymorphism (RFLP) and amplification refractory mutation system (ARMS) techniques.
  • The allele frequency of the Gly908Arg mutation did not differ, but the Arg702Trp and Leu1007fsinsC mutation were more common in CD patients than in controls.
  • The genotyping of these mutations might be used to identify high-risk patients.
  • [MeSH-major] Crohn Disease / genetics. Intracellular Signaling Peptides and Proteins / genetics. Mutation

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  • (PMID = 16126943.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; 0 / NOD2 protein, human; 0 / Nod2 Signaling Adaptor Protein
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21. Thomson A, Hayes R, Cousens S: Measures of between-cluster variability in cluster randomized trials with binary outcomes. Stat Med; 2009 May 30;28(12):1739-51
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  • We then assess how the assumptions of constant k or rho across treatment arms correspond to different assumptions about intervention effects.
  • [MeSH-minor] Analysis of Variance. Data Interpretation, Statistical. Humans. Models, Statistical. Odds Ratio. Risk. Sample Size. Treatment Outcome

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  • [Copyright] (c) 2009 John Wiley & Sons, Ltd.
  • (PMID = 19378266.001).
  • [ISSN] 0277-6715
  • [Journal-full-title] Statistics in medicine
  • [ISO-abbreviation] Stat Med
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0700837
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. Firoz B, Kovich OI, Latkowski JA: Mycosis fungoides with depigmentation secondary to treatment. Dermatol Online J; 2007;13(1):18
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  • A 51-year-old man presented with itchy, erythematous patches and plaques on his trunk, arms, and legs.
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 17511951.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; KTZ7ZCN2EX / Ficusin
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23. Kasumov VT, Ozalp-Yaman S, Taş E: Synthesis, spectroscopy and electrochemical behaviors of nickel(II) complexes with tetradentate shiff bases derived from 3,5-Bu(2)(t)-salicylaldehyde. Spectrochim Acta A Mol Biomol Spectrosc; 2005 Nov;62(1-3):716-20
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  • Nickel(II) complexes of a series of N,N'-polymethylenebis(3,5-Bu(2)(t)-salicylaldimine) ligands containing 2,4-di-Bu(2)(t)-phenol arms, NiL(x), were synthesized and their spectroscopic and redox properties were examined.
  • The UV-vis, (1)H NMR spectroscopic and magnetic results indicate that complexes NiL(1)-NiL(4) unlike NiL(5) and NiL(6) have a square-planar structure in the solid state and in solution.

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  • (PMID = 15876549.001).
  • [ISSN] 1386-1425
  • [Journal-full-title] Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
  • [ISO-abbreviation] Spectrochim Acta A Mol Biomol Spectrosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Schiff Bases; 17K64GZH20 / salicylaldehyde; 7OV03QG267 / Nickel
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24. Fridkin G, Bonasera TA, Litman P, Gilon C: Backbone metal-cyclization: a novel approach for simultaneous peptide cyclization and radiolabeling. Application to the combinatorial synthesis of rhenium-cyclic somatostatin analogs. Nucl Med Biol; 2005 Jan;32(1):39-50
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  • In this approach the metalo-cyclic peptides are prepared from their linear precursors through complexation of a metal atom via two hemi-chelating arms located on the peptide backbone.

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  • (PMID = 15691660.001).
  • [ISSN] 0969-8051
  • [Journal-full-title] Nuclear medicine and biology
  • [ISO-abbreviation] Nucl. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Metals; 0 / Peptide Library; 0 / Radioisotopes; 0 / Receptors, Somatostatin; 0 / somatostatin receptor 2; 51110-01-1 / Somatostatin; 7440-15-5 / Rhenium
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25. Heubl G: New aspects of DNA-based authentication of Chinese medicinal plants by molecular biological techniques. Planta Med; 2010 Dec;76(17):1963-74
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  • This review provides an account of the most commonly used DNA-based technologies (RAPD, RFLP, ARMS, CAPS, AFLP, DAF, ISSR, SSR, sequencing, hybridization and microarrays) including suitable examples of Chinese medical plants.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 21058240.001).
  • [ISSN] 1439-0221
  • [Journal-full-title] Planta medica
  • [ISO-abbreviation] Planta Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Plant
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26. Nie Z, Fava D, Rubinstein M, Kumacheva E: "Supramolecular" assembly of gold nanorods end-terminated with polymer "pom-poms": effect of pom-pom structure on the association modes. J Am Chem Soc; 2008 Mar 19;130(11):3683-9
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  • We report a predefined self-organization of gold nanorods (NRs) end-terminated with multiple polymer arms ("pom-poms") in higher-order structures.

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  • Hazardous Substances Data Bank. TRIMETHYLHEXADECYLAMMONIUM CHLORIDE .
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  • (PMID = 18298120.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / 1-R01-HL0775486A
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cetrimonium Compounds; 0 / Macromolecular Substances; 0 / Polystyrenes; 7440-57-5 / Gold; Z7FF1XKL7A / cetrimonium
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27. Ben-Yedidia T, Arnon R: Epitope-based vaccine against influenza. Expert Rev Vaccines; 2007 Dec;6(6):939-48
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  • The vaccine, activating both the humoral and cellular arms of the immune response, induces long-lasting protection against many strains of the influenza virus.
  • [MeSH-minor] Adjuvants, Immunologic. Animals. Disease Models, Animal. Drug Design. Epitope Mapping. Flagellin / immunology. Humans. Recombinant Proteins / immunology

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  • (PMID = 18034655.001).
  • [ISSN] 1744-8395
  • [Journal-full-title] Expert review of vaccines
  • [ISO-abbreviation] Expert Rev Vaccines
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antigens, Viral; 0 / Epitopes; 0 / Influenza Vaccines; 0 / Recombinant Proteins; 12777-81-0 / Flagellin
  • [Number-of-references] 65
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28. Kiowski W, Brunner H, Schalcher C: Sex, the heart, and heart failure. Semin Cardiothorac Vasc Anesth; 2006 Sep;10(3):256-8
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  • In the modern era of pharmacologic treatment of erectile dysfunction, men with heart disease increasingly approach their physicians regarding the possibility of restoring sexual activity.
  • At the same time, patients are also frequently aware of public figures that have reportedly died during coitus, often in the arms of their mistresses or prostitutes.
  • [MeSH-minor] 3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors. Cardiovascular Diseases / complications. Cardiovascular Diseases / drug therapy. Cardiovascular Diseases / physiopathology. Heart / physiology. Humans. Hypotension / chemically induced. Male. Nitrates / adverse effects. Nitrates / contraindications. Nitrates / therapeutic use. Risk Factors

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  • (PMID = 16959762.001).
  • [ISSN] 1089-2532
  • [Journal-full-title] Seminars in cardiothoracic and vascular anesthesia
  • [ISO-abbreviation] Semin Cardiothorac Vasc Anesth
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nitrates; 0 / Phosphodiesterase Inhibitors; 0 / Vasodilator Agents; EC 3.1.4.35 / 3',5'-Cyclic-GMP Phosphodiesterases
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29. Wichman HA, Millstein J, Bull JJ: Adaptive molecular evolution for 13,000 phage generations: a possible arms race. Genetics; 2005 May;170(1):19-31
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  • [Title] Adaptive molecular evolution for 13,000 phage generations: a possible arms race.
  • We instead suggest that continuing molecular evolution reflects a potentially indefinite arms race, stemming from high levels of co-infection and the resulting conflict among genomes competing within the same cell.

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  • (PMID = 15687276.001).
  • [ISSN] 0016-6731
  • [Journal-full-title] Genetics
  • [ISO-abbreviation] Genetics
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR016448; United States / NIGMS NIH HHS / GM / R01 GM057756; United States / NIGMS NIH HHS / GM / GM57756; United States / NCRR NIH HHS / RR / RR016448
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon
  • [Other-IDs] NLM/ PMC1449705
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30. Viprakasit V, Chinchang W: Two independent origins of Hb Dhonburi (Neapolis) [beta 126 (H4) Val-->Gly]: an electrophoretically silent hemoglobin variant. Clin Chim Acta; 2007 Feb;376(1-2):179-83
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  • A novel amplification refractory mutation system (ARMS-PCR) was developed and performed in five individuals with microcytosis and borderline Hb A(2).
  • In addition, 5 Hb Dhonburi heterozygotes, including 3 identified through thalassemia carrier screening, were identified by ARMS-PCR.
  • To overcome its 'silent' nature on electrophoresis, we proposed a novel ARMS-PCR for a rapid diagnosis of Hb Dhonburi in future cases.

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  • (PMID = 17007829.001).
  • [ISSN] 0009-8981
  • [Journal-full-title] Clinica chimica acta; international journal of clinical chemistry
  • [ISO-abbreviation] Clin. Chim. Acta
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Hemoglobins, Abnormal; 138932-11-3 / hemoglobin Dhonburi; 9004-22-2 / Globins
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31. Shepstone TN, Tang JE, Dallaire S, Schuenke MD, Staron RS, Phillips SM: Short-term high- vs. low-velocity isokinetic lengthening training results in greater hypertrophy of the elbow flexors in young men. J Appl Physiol (1985); 2005 May;98(5):1768-76
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  • Twelve subjects (23.8 +/- 2.4 yr; means +/- SD) performed maximal resistive lengthening isokinetic exercise with both arms for 8 wk (3 days/wk), during which they trained one arm at a Fast velocity while the contralateral arm performed an equivalent number of contractions at a Slow velocity.
  • Type I muscle fiber size increased Pre to Post (P < 0.05) in both Fast and Slow arms.
  • Type IIa and IIx muscle fiber CSA increased in both arms, but the increases were greater in the Fast- vs. the Slow-trained arm (P < 0.05).
  • Elbow flexor CSA increased in Fast and Slow arms, with the increase in the Fast arm showing a trend toward being greater (P = 0.06).

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  • (PMID = 15640387.001).
  • [ISSN] 8750-7587
  • [Journal-full-title] Journal of applied physiology (Bethesda, Md. : 1985)
  • [ISO-abbreviation] J. Appl. Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Jones EC: A call to arms: getting involved in advocacy. Med Health R I; 2010 Jun;93(6):175-6
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  • [Title] A call to arms: getting involved in advocacy.
  • [MeSH-minor] Leadership. Societies, Medical. United States

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  • (PMID = 20632714.001).
  • [ISSN] 1086-5462
  • [Journal-full-title] Medicine and health, Rhode Island
  • [ISO-abbreviation] Med Health R I
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Kobayashi H, Morita K, Takeshi K, Koshikawa H, Yamazawa R, Kashima H, Mizuno M: Effects of aripiprazole on insight and subjective experience in individuals with an at-risk mental state. J Clin Psychopharmacol; 2009 Oct;29(5):421-5
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  • [Title] Effects of aripiprazole on insight and subjective experience in individuals with an at-risk mental state.
  • Clinical insight was measured using the Scale to Assess Unawareness of Mental Disorder, and changes in subjective experience were assessed using the Subjective Well-being Under Neuroleptics, Short version.
  • Improvements on the Scale of Prodromal Symptoms and Scale to Assess Unawareness of Mental Disorder scores were statistically significant at end point.
  • Although further placebo-controlled studies are needed, aripiprazole might be a first-line treatment for individuals at imminent risk for psychosis.
  • [MeSH-minor] Adolescent. Adult. Aripiprazole. Female. Follow-Up Studies. Humans. Male. Risk Factors. Treatment Outcome. Young Adult

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  • (PMID = 19745640.001).
  • [ISSN] 1533-712X
  • [Journal-full-title] Journal of clinical psychopharmacology
  • [ISO-abbreviation] J Clin Psychopharmacol
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Piperazines; 0 / Quinolones; 82VFR53I78 / Aripiprazole
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34. Lacerra G, Scarano C, Lagona LF, Testa R, Caruso DG, Medulla E, Friscia MG, Mastrullo L, Caldora M, Prezioso R, Gaudiano C, Magnano C, Romeo MA, Musollino G, Di Noce F, Carestia C: Genotype-phenotype relationship of the δ-thalassemia and Hb A(2) variants: observation of 52 genotypes. Hemoglobin; 2010;34(5):407-23
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  • Factors decreasing Hb A(2) percentages can hinder correct diagnosis.
  • Mutations were detected with allele-specific methods or DNA sequencing; two multiplex-ARMS (amplification refractory mutation system) assays were set up.
  • These results are extremely useful in addressing the molecular diagnosis of hemoglobinopathies and thalassemias.
  • [MeSH-major] Hemoglobin A2 / genetics. Mutation. delta-Thalassemia / genetics

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  • (PMID = 20854114.001).
  • [ISSN] 1532-432X
  • [Journal-full-title] Hemoglobin
  • [ISO-abbreviation] Hemoglobin
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / alpha-Globins; 0 / beta-Globins; 0 / delta-Globins; 9034-53-1 / Hemoglobin A2
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35. Vecera J, Vojtísek P, Varvarovský I, Lojík M, Másová K, Kvasnicka J: Non-invasive diagnosis of coronary-subclavian steal: role of the Doppler ultrasound. Eur J Echocardiogr; 2010 Oct;11(9):E34
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  • [Title] Non-invasive diagnosis of coronary-subclavian steal: role of the Doppler ultrasound.
  • After successful resuscitation, blood pressure difference between both arms and abnormal LIMA flow with systolic reversal flow on the Doppler ultrasonography were suggestive of CSSS.

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  • (PMID = 20495201.001).
  • [ISSN] 1532-2114
  • [Journal-full-title] European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology
  • [ISO-abbreviation] Eur J Echocardiogr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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36. Reinholz J, Skopp O, Breitenstein C, Winterhoff H, Knecht S: Better than normal: improved formation of long-term spatial memory in healthy rats treated with levodopa. Exp Brain Res; 2009 Feb;192(4):745-9
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  • Consequently, treatment with the dopamine precursor levodopa ameliorates memory deficits in murine models of Alzheimer's disease.
  • After 4 months, rats treated with levodopa during training had significantly better memory of food rewarded arms than vehicle-treated animals.

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  • (PMID = 19043682.001).
  • [ISSN] 1432-1106
  • [Journal-full-title] Experimental brain research
  • [ISO-abbreviation] Exp Brain Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 46627O600J / Levodopa
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37. Piccione M, Maresi E, Zollino M, Sanfilippo C, Seminara L, Neri G, Corsello G: Sex reversal from functional disomy of Xp: prenatal and post-mortem findings. Am J Med Genet A; 2008 Oct 15;146A(20):2681-7
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  • Translocations involving the short arms of the X and Y chromosomes are uncommon and are often associated with anomalies in gonadal development.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 14 / genetics. Chromosomes, Human, X / genetics. Disorders of Sex Development. Prenatal Diagnosis. Sex Chromosome Aberrations. Sex Chromosomes / genetics

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  • [Copyright] 2008 Wiley-Liss, Inc.
  • (PMID = 18798322.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Li ZY, Fu ML, Hu FF, Huang SF, Song YC: Visualization of the ribosomal DNA (45S rDNA) of Indica rice with FISH on some phases of cell cycle and extended DNA fibers. Biocell; 2006 Apr;30(1):27-32
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  • The results show that 45S rDNA is located at the ends of short arms of chromosomes 9 and 10.

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  • (PMID = 16845825.001).
  • [ISSN] 0327-9545
  • [Journal-full-title] Biocell : official journal of the Sociedades Latinoamericanas de Microscopía Electronica ... et. al
  • [ISO-abbreviation] Biocell
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Argentina
  • [Chemical-registry-number] 0 / DNA, Plant; 0 / DNA, Ribosomal
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39. Guilemany JM, Romero E, Blanch JL: An aesthetic deformity: Madelung's disease. Acta Otolaryngol; 2005 Mar;125(3):328-30
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  • [Title] An aesthetic deformity: Madelung's disease.
  • Madelung's disease, also known as benign symmetric lipomatosis, multiple symmetrical lipomatosis or Lanois-Bensaude syndrome, consists of growth of fatty masses predominantly on the face, neck, shoulders, upper thorax and arms.
  • The aetiology of Madelung's disease remains unknown, although approximately = 60% of affected patients are clinically overweight and there is an intimate association with chronic alcohol abuse.
  • We report an unusual case of Madelung's disease in a 52-year-old male.
  • The patient remains well and disease-free after 12 months of postoperative follow-up.

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  • (PMID = 15966707.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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40. Bonetti M, Zahrieh D, Cole BF, Gelber RD: A small sample study of the STEPP approach to assessing treatment-covariate interactions in survival data. Stat Med; 2009 Apr 15;28(8):1255-68
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  • A new, intuitive method has recently been proposed to explore treatment-covariate interactions in survival data arising from two treatment arms of a clinical trial.

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  • (PMID = 19170050.001).
  • [ISSN] 0277-6715
  • [Journal-full-title] Statistics in medicine
  • [ISO-abbreviation] Stat Med
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA075362-11; United States / NCI NIH HHS / CA / U24 CA075362; United States / NCI NIH HHS / CA / CA-75362; United States / NCI NIH HHS / CA / U24 CA075362-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS147360; NLM/ PMC2843827
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41. Silversides JD, Allan CC, Archibald SJ: Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis. Dalton Trans; 2007 Mar 07;(9):971-8
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  • The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring.
  • An analysis of deposited data from over one hundred copper(II) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid state.

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  • Hazardous Substances Data Bank. COPPER, ELEMENTAL .
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  • (PMID = 17308678.001).
  • [ISSN] 1477-9226
  • [Journal-full-title] Dalton transactions (Cambridge, England : 2003)
  • [ISO-abbreviation] Dalton Trans
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 069719
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lactams, Macrocyclic; 0 / Radiopharmaceuticals; 789U1901C5 / Copper
  • [Other-IDs] NLM/ PMC1978068; NLM/ UKMS761
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42. Shishkina GT, Iudina AM, Dygalo NN: [Effects of fluoxetine on locomotor activity: possible involvement of dopamine]. Zh Vyssh Nerv Deiat Im I P Pavlova; 2006 Jul-Aug;56(4):523-8
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  • This is supported by a significant correlation between the dopamine content in the frontal cortex and the number of entries into the closed arms of the plus-maze.
  • The results suggest that the hypolocomotor effect of fluoxetine may involve the changes in the dopaminergic system.

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  • (PMID = 17025197.001).
  • [ISSN] 0044-4677
  • [Journal-full-title] Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova
  • [ISO-abbreviation] Zh Vyssh Nerv Deiat Im I P Pavlova
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Serotonin Uptake Inhibitors; 01K63SUP8D / Fluoxetine; 54-16-0 / Hydroxyindoleacetic Acid; VTD58H1Z2X / Dopamine
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43. Lidén C, Skare L, Lind B, Nise G, Vahter M: Assessment of skin exposure to nickel, chromium and cobalt by acid wipe sampling and ICP-MS. Contact Dermatitis; 2006 May;54(5):233-8
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  • The recovery of nickel, chromium and cobalt from arms and palms was 93%.
  • The technique may be used in workplace studies, in studies of individuals in the general population, in dermatitis patients, in identification of risk groups, as well as in developing preventive strategies and in follow-up after intervention.
  • [MeSH-major] Allergens. Dermatitis, Allergic Contact / diagnosis. Skin Tests / methods

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  • Hazardous Substances Data Bank. CHROMIUM, ELEMENTAL .
  • Hazardous Substances Data Bank. COBALT, ELEMENTAL .
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  • (PMID = 16689805.001).
  • [ISSN] 0105-1873
  • [Journal-full-title] Contact dermatitis
  • [ISO-abbreviation] Contact Derm.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Allergens; 0R0008Q3JB / Chromium; 3G0H8C9362 / Cobalt; 7OV03QG267 / Nickel
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44. Simoes AA, Bastos FI, Moreira RI, Lynch KG, Metzger DS: A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, Brazil. J Subst Abuse Treat; 2006 Apr;30(3):237-43
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  • [Title] A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, Brazil.
  • This study compares drug patterns and prevalence of risk behaviors in a randomized trial using two methods of administration, Audio Computer-Assisted Self-Interview (ACASI) and Interviewer-Administered Questionnaire (IAQ), among drug users seeking treatment in a drug treatment center.
  • No significant difference in sociodemographic variables were found between subjects in the two arms of the study.
  • Rates of reporting of sexual risk behaviors (male-to-male and commercial sex) were higher among participants in the ACASI arm.
  • [MeSH-minor] Adolescent. Adult. Alcohol Drinking / epidemiology. Brazil / epidemiology. Computers. Female. Humans. Male. Middle Aged. Prostitution. Risk-Taking. Sexual Behavior. Surveys and Questionnaires


45. Leigheb G, Tiberio R, Filosa G, Bugatti L, Ciattaglia G: Thysanoptera dermatitis. J Eur Acad Dermatol Venereol; 2005 Nov;19(6):722-4
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  • The cutaneous lesions formed are small pink and itchy papules localized mainly on the trunk and the arms.
  • Diagnosis is only possible by demonstrating that the insect is present inside one of the lesions of the skin.
  • Although self-resolving in a few days, Thysanoptera dermatitis should be known not only for the cultural and scientific training of the dermatologist but also to add more detailed diagnostic information to the generic diagnosis of 'entomodermatosis' and to confirm the benign evolution of the bites.
  • [MeSH-major] Dermatitis / diagnosis. Dermatitis / parasitology. Hemiptera. Insect Bites and Stings / diagnosis
  • [MeSH-minor] Adult. Animals. Diagnosis, Differential. Humans. Male. Ointments. Steroids / therapeutic use

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  • (PMID = 16268878.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ointments; 0 / Steroids
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46. Melfi FM, Ambrogi MC, Lucchi M, Mussi A: Video robotic lobectomy. Multimed Man Cardiothorac Surg; 2005 Jan 1;2005(628):mmcts.2004.000448
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  • The da Vinci™ Robotic System (Intuitive Surgical, Inc, CA, USA) is one of these robots.
  • It consists of a console and a surgical cart supporting three articulated robotic arms.
  • After a period of technical development and training we used the robotic systems to treat patients with various thoracic diseases.

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  • (PMID = 24414727.001).
  • [Journal-full-title] Multimedia manual of cardiothoracic surgery : MMCTS
  • [ISO-abbreviation] Multimed Man Cardiothorac Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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47. Braeken E, De Cremer G, Marsal P, Pèpe G, Müllen K, Vallée RA: Single molecule probing of the local segmental relaxation dynamics in polymer above the glass transition temperature. J Am Chem Soc; 2009 Sep 2;131(34):12201-10
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  • Owing to molecular mechanics and quantum calculations, we could assign the conformational changes to folding/unfolding event(s) of one or more arms with respect to the conjugated core.

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  • (PMID = 19655758.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Georgy M, Yonescu R, Griffin CA, Batista DA: Acute mixed lineage leukemia and a t(6;14)(q25;q32) in two adults. Cancer Genet Cytogenet; 2008 Aug;185(1):28-31
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  • A translocation involving the long arms of chromosomes 6 and 14 was previously described in four young individuals with acute leukemia and in three of these cases the diagnosis was mixed lineage.

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  • (PMID = 18656690.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Robertson HM, Gordon KH: Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera. Genome Res; 2006 Nov;16(11):1345-51
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  • [Title] Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera.
  • This simple subtelomeric structure differs from the centromeric-proximal telomeres on the short arms of the 15 acrocentric chromosomes, which are apparently composed primarily of the 176-bp AluI tandem repeat.

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  • (PMID = 17065609.001).
  • [ISSN] 1088-9051
  • [Journal-full-title] Genome research
  • [ISO-abbreviation] Genome Res.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI056081; United States / NIAID NIH HHS / AI / AI56081
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC1626636
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50. Weisser B, Gerwe M, Braun M, Funken C: [Investigations of the antihypertensive long-term action of candesartan cilexetil in different dosages under the influence of therapy-free intervals]. Arzneimittelforschung; 2005;55(9):505-13
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  • INTRODUCTION: In a randomized, phase IV clinical study with 4 parallel treatment arms, the long-lasting treatment effect of candesartan cilexetil (CAS 145040-37-5, CC, Blopress) was to be demonstrated for a repeated therapy-free interval of 48 h in the dosages 8 and 16 mg with or without hydrochlorothiazide 12.5 mg (CAS 58-93-5, HCT; 4 groups totally).
  • The patient allocation to the 4 treatment arms as well as the conditions at study start concerning demographic data, physical investigation, patient history, ECG, concomitant diseases/therapy and baseline values of blood pressure were well comparable between the four groups.
  • Furthermore, statistically significant differences between the four treatment arms could not be detected regarding the long-lasting blood pressure lowering effect over As for tolerability the entire study provides no evidence on new or unknown pathologic drug reactions as well as on a frequent occurrence of specific adverse events or relevant laboratory changes.

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  • (PMID = 16229114.001).
  • [ISSN] 0004-4172
  • [Journal-full-title] Arzneimittel-Forschung
  • [ISO-abbreviation] Arzneimittelforschung
  • [Language] ger
  • [Publication-type] Clinical Trial; Clinical Trial, Phase IV; English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Benzimidazoles; 0 / Biphenyl Compounds; 0 / Diuretics; 0 / Tetrazoles; 0J48LPH2TH / Hydrochlorothiazide; R85M2X0D68 / candesartan cilexetil
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51. Eve HE, Linch D, Qian W, Ross M, Seymour JF, Smith P, Stevens L, Rule SA: Toxicity of fludarabine and cyclophosphamide with or without rituximab as initial therapy for patients with previously untreated mantle cell lymphoma: results of a randomised phase II study. Leuk Lymphoma; 2009 Feb;50(2):211-5
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  • The combination of FC is well-recognised as significantly immunosuppressive and there are concerns that adding rituximab may increase infection risk further.
  • Non-hematological toxicity was similar between the two treatment arms.

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  • (PMID = 19197729.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] ENG
  • [Grant] United Kingdom / Cancer Research UK / / 5665; United Kingdom / Cancer Research UK / /
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 8N3DW7272P / Cyclophosphamide; FA2DM6879K / Vidarabine; P2K93U8740 / fludarabine
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52. Gaskett AC, Winnick CG, Herberstein ME: Orchid sexual deceit provokes ejaculation. Am Nat; 2008 Jun;171(6):E206-12
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  • The costs of sperm wastage could select for pollinator avoidance of orchids, thereby driving and maintaining sexual deception via antagonistic coevolution or an arms race between pollinator learning and escalating orchid mimicry.


53. Minc N, Viovy JL, Dorfman KD: Non-markovian transport of DNA in microfluidic post arrays. Phys Rev Lett; 2005 May 20;94(19):198105
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  • The motion is a repetitive three-part cycle: (i) collision with the post and extension of the arms;.

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  • (PMID = 16090219.001).
  • [ISSN] 0031-9007
  • [Journal-full-title] Physical review letters
  • [ISO-abbreviation] Phys. Rev. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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54. Brinkman SA, Johnson SE, Lawrence D, Codde JP, Hart MB, Straton JA, Silburn S: Study protocol for the evaluation of an Infant Simulator based program delivered in schools: a pragmatic cluster randomised controlled trial. Trials; 2010;11:100
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  • The aim of this trial is to evaluate the Virtual Infant Parenting (VIP) program by investigating pre-conceptual health and risk behaviours, teen pregnancy and the resultant birth outcomes, early child health and maternal health.
  • METHODS AND DESIGN: Fifty-seven schools (86% of 66 eligible secondary schools) in Perth, Australia were recruited to the clustered (by school) randomised trial, with even randomisation to the intervention and control arms.
  • Kaplan-Meier survival analysis and proportional hazards regression will test for differences in pregnancy, birth and abortion rates during the teenage years between the study arms.


55. Acuna M, Amasay T, Karduna AR: The reliability of side to side measurements of upper extremity activity levels in healthy subjects. BMC Musculoskelet Disord; 2010 Jul 22;11:168
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  • Each subject wore a triaxial accelerometer on both arms for three and a half hours.
  • CONCLUSIONS: In general, the mean activity levels during daily activities were very similar between dominant and non-dominant arms.

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  • (PMID = 20650006.001).
  • [ISSN] 1471-2474
  • [Journal-full-title] BMC musculoskeletal disorders
  • [ISO-abbreviation] BMC Musculoskelet Disord
  • [Language] ENG
  • [Grant] United States / NIOSH CDC HHS / OH / 5R01OH008288
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2914700
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56. Khan FA, Minion J, Pai M, Royce S, Burman W, Harries AD, Menzies D: Treatment of active tuberculosis in HIV-coinfected patients: a systematic review and meta-analysis. Clin Infect Dis; 2010 May 1;50(9):1288-99
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  • BACKGROUND: Patients with human immunodeficiency virus (HIV) infection and tuberculosis have an increased risk of death, treatment failure, and relapse.
  • In included studies, the initial tuberculosis diagnosis, failure, and/or relapse were microbiologically confirmed, and patients received standardized rifampin- or rifabutin-containing regimens.
  • Relapse was more common with regimens using 2 months rifamycin (adjusted risk ratio, 3.6; 95% confidence interval, 1.1-11.7) than with regimens using rifamycin for at least 8 months.
  • Compared with daily therapy in the initial phase (n=3352 patients from 35 study arms), thrice-weekly therapy (n=211 patients from 5 study arms) was associated with higher rates of failure (adjusted risk ratio, 4.0; 95% confidence interval, 1.5-10.4) and relapse [adjusted risk ratio, 4.8; 95% confidence interval, 1.8-12.8).

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  • (PMID = 20353364.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Antitubercular Agents; VJT6J7R4TR / Rifampin
  • [Number-of-references] 67
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57. Milla P, Airoldi M, Weber G, Drescher A, Jaehde U, Cattel L: Administration of reduced glutathione in FOLFOX4 adjuvant treatment for colorectal cancer: effect on oxaliplatin pharmacokinetics, Pt-DNA adduct formation, and neurotoxicity. Anticancer Drugs; 2009 Jun;20(5):396-402
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  • There were no significant differences in the main pharmacokinetic parameters between the two arms except a lower area under the plasma concentration-time curve and a smaller apparent steady-state volume of distribution (Vss) when GSH was coadministered.
  • The determination of Pt-DNA adduct formation shows no statistically significant differences between the two arms.
  • [MeSH-major] Adenocarcinoma / drug therapy. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Colorectal Neoplasms / drug therapy. DNA Adducts / drug effects. Glutathione / pharmacology. Organoplatinum Compounds / pharmacokinetics. Peripheral Nervous System Diseases / prevention & control

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  • (PMID = 19287306.001).
  • [ISSN] 1473-5741
  • [Journal-full-title] Anti-cancer drugs
  • [ISO-abbreviation] Anticancer Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Adducts; 0 / Organoplatinum Compounds; 04ZR38536J / oxaliplatin; GAN16C9B8O / Glutathione; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; Folfox protocol
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58. Ardizzoni A, Favaretto A, Boni L, Baldini E, Castiglioni F, Antonelli P, Pari F, Tibaldi C, Altieri AM, Barbera S, Cacciani G, Raimondi M, Tixi L, Stefani M, Monfardini S, Antilli A, Rosso R, Paccagnella A: Platinum-etoposide chemotherapy in elderly patients with small-cell lung cancer: results of a randomized multicenter phase II study assessing attenuated-dose or full-dose with lenograstim prophylaxis--a Forza Operativa Nazionale Italiana Carcinoma Polmonare and Gruppo Studio Tumori Polmonari Veneto (FONICAP-GSTPV) study. J Clin Oncol; 2005 Jan 20;23(3):569-75
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  • PURPOSE: Small-cell lung cancer (SCLC) is increasingly diagnosed in elderly patients, who are at higher risk of treatment-related morbidity and mortality.
  • Seventy-five percent and 72% of the patients in the AD and FD arms, respectively, completed the treatment as per protocol.
  • Response rate was 39% and 69% in the AD and FD arms, respectively, and 1-year survival probability was 18% and 39%, respectively.

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  • (PMID = 15659503.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Recombinant Proteins; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 6PLQ3CP4P3 / Etoposide; 6WS4C399GB / lenograstim; Q20Q21Q62J / Cisplatin
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59. Jung JY, Yeom KB, Eun HC: Chemical Leukoderma Improved by Low-dose Steroid Pulse Therapy. Ann Dermatol; 2010 May;22(2):241-4
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  • We report a healthy 51-year-old man who had multiple hypopigmented macules and patches on his face, neck, arms and legs after exposure to occupationally related chemicals.

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  • (PMID = 20548927.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2883439
  • [Keywords] NOTNLM ; Chemical leukoderma / Systemic steroid / Vitiligo
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60. Jia J, Yang Z, Li G, Liu Ch, Lei M, Zhang T, Zhou J, Ren Z: Isolation and chromosomal distribution of a novel Ty1-copia-like sequence from Secale, which enables identification of wheat-Secale africanum introgression lines. J Appl Genet; 2009;50(1):25-8
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  • Fluorescence in situ hybridization (FISH) analyses indicated that pSaO5411 was significantly hybridized to S. africanum chromosomes of a wheat-S. africanum amphiploid, and it was dispersed along the Secale chromosome arms except the terminal regions.

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  • (PMID = 19193979.001).
  • [ISSN] 1234-1983
  • [Journal-full-title] Journal of applied genetics
  • [ISO-abbreviation] J. Appl. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromatin; 0 / Genetic Markers; 0 / Retroelements
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61. Galaup C, Couchet JM, Bedel S, Tisnès P, Picard C: Direct access to terpyridine-containing polyazamacrocycles as photosensitizing ligands for Eu(III) luminescence in aqueous media. J Org Chem; 2005 Mar 18;70(6):2274-84
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  • [reaction: see text] The synthesis of new 18-membered hexaazamacrocycles containing a functionalized 2,2':6',2' '-terpyridine moiety as part of the cyclic backbone and three acetate pendant arms is described.

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  • (PMID = 15760215.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aza Compounds; 0 / Hydrocarbons, Cyclic; 0 / Ligands; 0 / Organometallic Compounds; 0 / Pyridines; 059QF0KO0R / Water; 444W947O8O / Europium; G5E357ISH5 / 2,2',2''-terpyridine
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62. Shishimi G, Nakajima S: Contextual control of rats' foraging behaviour in a radial maze. Behav Processes; 2007 Jan 10;74(1):97-103
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  • Four of the eight arms were context-dependent: two arms were baited in the "night" context, while the other two were baited in the "daytime" context.
  • The remaining four arms were context-independent: three of them were never baited, while the remaining one was baited in both contexts.
  • The rats gradually began to avoid the arms that were uniquely baited in the other context, suggesting a contextual or conditional control of arm selection.
  • Interestingly, these rats also showed better performance in avoiding the never-baited arms, compared with control rats.
  • Namely, disambiguating the incentive values of the four arms by contextual cues collaterally facilitated the context-independent arm performance.
  • Another interesting finding of the present study is that the rats did not visit the always-baited arm earlier than the arms uniquely baited in that context.

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  • (PMID = 17140749.001).
  • [ISSN] 0376-6357
  • [Journal-full-title] Behavioural processes
  • [ISO-abbreviation] Behav. Processes
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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63. Hui HE, Beals TC, Brown NA: Influence of tendon transfer site on moment arms of the flexor digitorum longus muscle. Foot Ankle Int; 2007 Apr;28(4):441-7
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  • [Title] Influence of tendon transfer site on moment arms of the flexor digitorum longus muscle.
  • The purpose of this study was to calculate FDL muscle moment arms at the hindfoot with two clinically relevant transfer locations to quantify the change in mechanical advantage of the FDL after tendon transfer.
  • METHODS: In seven cadaver specimens, muscle moment arms of the FDL with respect to hindfoot motion were measured using the tendon excursion method before and after the FDL was transferred to the plantar aspect of the navicular and medial cuneiform.
  • The position and orientation of the foot and excursion of the FDL tendon were measured with an optoelectronic measurement system.
  • CONCLUSIONS: In contrast to the clinical proposition that FDL transfer to the navicular or medial cuneiform increases this muscle's mechanical advantage to invert the hindfoot, this cadaver study suggests that, to the contrary, FDL muscle moment arms decrease after tendon transfer.

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  • (PMID = 17475138.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Gabos PG: Modified technique for the surgical treatment of congenital constriction bands of the arms and legs of infants and children. Orthopedics; 2006 May;29(5):401-4
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  • [Title] Modified technique for the surgical treatment of congenital constriction bands of the arms and legs of infants and children.
  • The combination of circumferential subcutaneous fat advancement flaps and Z-plasties allows for single-stage treatment of congenital constriction bands of the arms and legs of infants and children.

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  • (PMID = 16729738.001).
  • [ISSN] 0147-7447
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Smith ML, Gourdon D, Little WC, Kubow KE, Eguiluz RA, Luna-Morris S, Vogel V: Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol; 2007 Oct 2;5(10):e268
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  • Fn extensibility under the influence of cell traction forces has been proposed to originate either from the force-induced lengthening of an initially compact, folded quaternary structure as is found in solution (quaternary structure model, where the dimeric arms of Fn cross each other), or from the force-induced unfolding of type III modules (unfolding model).
  • The compactly folded quaternary structure with crossed Fn arms, however, was never detected within extracellular matrix fibrils.
  • We conclude that the resting state of Fn fibrils does not contain Fn molecules with crossed-over arms, and that the several-fold extensibility of Fn fibrils involves the unfolding of type III modules.

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  • (PMID = 17914904.001).
  • [ISSN] 1545-7885
  • [Journal-full-title] PLoS biology
  • [ISO-abbreviation] PLoS Biol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / PN2 EY016586
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibronectins
  • [Other-IDs] NLM/ PMC1994993
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66. Ishizuka Y, Abe H, Tanoue A, Kannan H, Ishida Y: Involvement of vasopressin V1b receptor in anti-anxiety action of SSRI and SNRI in mice. Neurosci Res; 2010 Mar;66(3):233-7
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  • Previous studies showed that AVP facilitates aggression while serotonin inhibits aggression by blocking the activity of the vasopressin system.
  • To examine whether the interaction of the V1bR and serotonin in the central nervous system controls anxiety-related behavior, we investigated the effects of acute and chronic treatment with a selective serotonin reuptake inhibitor (SSRI) and with a serotonin noradrenalin reuptake inhibitor (SNRI) on V1bR knockout (KO) mice and on V1bR antagonist (SSR149415)-treated mice.
  • For both the V1bR KO mice and V1bR antagonist-treated mice, acute treatment with either SSRI or SNRI did not change the time spent on the EPM open arms or the number of head dips in the HB.
  • Chronic treatment of V1bR KO mice with SSRI did not change the amount of time spent on the open arms, the number of head dips, or the number of rearings, while chronic treatment with SNRI significantly increased the time spent on the open arms and the number of head dips.

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  • (PMID = 19914307.001).
  • [ISSN] 1872-8111
  • [Journal-full-title] Neuroscience research
  • [ISO-abbreviation] Neurosci. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / 1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide; 0 / Antidiuretic Hormone Receptor Antagonists; 0 / Indoles; 0 / Neurotransmitter Uptake Inhibitors; 0 / Pyrrolidines; 0 / Receptors, Vasopressin; 0 / Serotonin Uptake Inhibitors; 333DO1RDJY / Serotonin
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67. Chanan-Khan A, Sonneveld P, Schuster MW, Stadtmauer EA, Facon T, Harousseau JL, Ben-Yehuda D, Lonial S, Goldschmidt H, Reece D, Neuwirth R, Anderson KC, Richardson PG: Analysis of herpes zoster events among bortezomib-treated patients in the phase III APEX study. J Clin Oncol; 2008 Oct 10;26(29):4784-90
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  • Most herpes zoster infections were grade 1/2; incidences of grade 3/4 events (1.8% v 1.5%) and infections considered serious adverse events (1.5% v 0.9%) were similar between treatment arms, and no herpes zoster-related deaths occurred.
  • Neither the time to onset of the herpes event nor the patients' absolute lymphocyte counts at baseline differed significantly between arms.
  • The incidence of non-VZV-related herpes viral infections was comparable between arms.
  • No additional risk factors for herpes zoster reactivation were identified.
  • CONCLUSION: Further studies are needed to explain these observations and their implications; however, for patients treated with bortezomib or bortezomib-containing regimens, the risk of VZV reactivation should be monitored and routine use of antiviral prophylaxis considered.

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  • [CommentIn] J Clin Oncol. 2009 May 1;27(13):2293-4; author reply 2294-6 [19307496.001]
  • (PMID = 18711175.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Pyrazines; 69G8BD63PP / Bortezomib
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68. Koeberle D, Thuerlimann B: Letrozole as upfront endocrine therapy for postmenopausal women with hormone-sensitive breast cancer: BIG 1-98. Breast Cancer Res Treat; 2007;105 Suppl 1:55-66
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  • This pre-planned core analysis allowed the use of patient data from the monotherapy arms of letrozole and tamoxifen and from the sequential arms prior to the drug switch point.
  • Patients randomized to letrozole had a 19% improved disease-free survival (hazard ratio [HR]=0.81; P=0.003), due especially to reduced distant metastases (HR=0.73; P=0.001).
  • A 14% risk reduction of fatal events in favor of letrozole was also observed (P=NS).
  • The results from the monotherapy arms alone confirmed the findings from the primary core analysis.
  • Based on the results from this trial, the aromatase inhibitor letrozole (Femara) is currently recommended as a part of standard adjuvant therapy for postmenopausal women with endocrine-responsive breast cancer and has recently been approved in the early adjuvant setting in both Europe and the United States.
  • [MeSH-minor] Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease-Free Survival. Double-Blind Method. Drug Administration Schedule. Europe. Female. Humans. Middle Aged. Neoadjuvant Therapy. Postmenopause. Treatment Outcome. United States

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  • (PMID = 17912636.001).
  • [ISSN] 0167-6806
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Aromatase Inhibitors; 0 / Nitriles; 0 / Triazoles; 094ZI81Y45 / Tamoxifen; 7LKK855W8I / letrozole
  • [Other-IDs] NLM/ PMC2001218
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69. Roach M 3rd: Dose escalated external beam radiotherapy versus neoadjuvant androgen deprivation therapy and conventional dose external beam radiotherapy for clinically localized prostate cancer: do we need both? Strahlenther Onkol; 2007 Dec;183 Spec No 2:26-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: To date 4 randomized trials, including 10 arms and approximately 1600 men have reported comparing patients treated with EBRT alone to EBRT combined with short-term NADT.
  • To date, four Phase III dose escalation trials have been completed including 8 arms and a total of approximately 2210 patients with doses up to 74 to 79 Gy compared to doses of 64 to 70 Gy on the control arms.
  • [MeSH-minor] Antineoplastic Agents, Hormonal / therapeutic use. Clinical Trials, Phase III as Topic. Follow-Up Studies. Humans. Male. Neoadjuvant Therapy. Neoplasm Metastasis. Prospective Studies. Prostate-Specific Antigen / blood. Radiotherapy Dosage. Randomized Controlled Trials as Topic. Time Factors. Treatment Outcome

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  • (PMID = 18167004.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Antineoplastic Agents, Hormonal; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Number-of-references] 18
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70. Iwata E, Kikusui T, Takeuchi Y, Mori Y: Fostering and environmental enrichment ameliorate anxious behavior induced by early weaning in Balb/c mice. Physiol Behav; 2007 Jun 8;91(2-3):318-24
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  • In elevated plus-maze tests, 10-week-old pups reared with a foster mother spent more time in the open arms than early-weaned mice, and entered into the open arms at a rate between that of normally- and early-weaned mice.
  • The enriched environment increased the duration of time spent in the open arms, but the magnitude of the effect varied with the rearing condition.

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  • (PMID = 17434546.001).
  • [ISSN] 0031-9384
  • [Journal-full-title] Physiology & behavior
  • [ISO-abbreviation] Physiol. Behav.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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71. Oda M, Uchiyama S, Robinson CV, Fukui K, Kobayashi Y, Azuma T: Regional and segmental flexibility of antibodies in interaction with antigens of different size. FEBS J; 2006 Apr;273(7):1476-87
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  • When both Abs and Ags were free in solution, sedimentation equilibrium and surface plasmon resonance analyses showed the formation of an Ag(2)Ab(1) complexes regardless of Ag size, suggesting that the Fab arms were able to move to avoid interference between Ags bound to Ab combining sites.
  • These results indicated that immobilization of the Fc region reduces the dynamic range of the Fab arms and results in interference from the first Ag bound to either combining site, which in turn prevents the binding of the second Ag to the other combining site.
  • Our results allow us to propose that the Fab arms of B-cell receptors whose Fc regions are immobilized on cell surface have a reduced dynamic range.

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  • (PMID = 16689933.001).
  • [ISSN] 1742-464X
  • [Journal-full-title] The FEBS journal
  • [ISO-abbreviation] FEBS J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens; 0 / Multiprotein Complexes; 0 / Serum Albumin; 9006-59-1 / Ovalbumin
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72. Endo Y, Ohta M, Shibata K, Kai S, Iwaki K, Uchida H, Ogata M, Ikewaki J, Kashima K, Kitano S: Splenectomy for hypersplenism caused by adult T-cell leukemia: report of a case. Surg Today; 2008;38(12):1148-51
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  • A 45-year-old woman with previously diagnosed chronic type adult T-cell leukemia (ATL) presented with abdominal discomfort and red eruptions on her arms and legs.
  • We performed splenectomy in an attempt to reduce the total volume of malignant cells and improve the hypersplenism.
  • Splenectomy should be considered as an optional treatment for hypersplenism caused by ATL when hypersplenism cannot be controlled by chemotherapy in patients without a high surgical risk.
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Disease Progression. Erythrocyte Transfusion. Female. Humans. Middle Aged. Platelet Transfusion. Spleen / pathology. Splenomegaly

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  • (PMID = 19039645.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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73. Kateneva AV, Dresser ME: Sister chromatid cohesion remodeling and meiotic recombination. Cell Cycle; 2006 Mar;5(5):467-71
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  • Proper control of cohesion along the chromosome arms is essential for segregation of homologous chromosomes in meiosis.
  • Finding that the same defect in separation of sister chromatids could be suppressed by disrupting the functions of these proteins supports the emerging recognition that cohesion is remodeled during recombination and further indicates that cohesion is modified specifically to regulate meiotic recombination.

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  • (PMID = 16552182.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / GM-45250-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fungal Proteins
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74. Ruiz de Angulo V, Torras C: Speeding up the learning of robot kinematics through function decomposition. IEEE Trans Neural Netw; 2005 Nov;16(6):1504-12
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  • The main drawback of using neural networks or other example-based learning procedures to approximate the inverse kinematics (IK) of robot arms is the high number of training samples (i.e., robot movements) required to attain an acceptable precision.

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  • (PMID = 16342491.001).
  • [ISSN] 1045-9227
  • [Journal-full-title] IEEE transactions on neural networks
  • [ISO-abbreviation] IEEE Trans Neural Netw
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Mi XJ, Chen SW, Wang WJ, Wang R, Zhang YJ, Li WJ, Li YL: Anxiolytic-like effect of paeonol in mice. Pharmacol Biochem Behav; 2005 Jul;81(3):683-7
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  • As with 2 mg/kg diazepam, paeonol (at 17.5 mg/kg) increased the percentage of time spent on open arms in the elevated plus maze and increased the time spent in the light area of the light/dark box (at 8.75 and 17.5 mg/kg).

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  • (PMID = 15970315.001).
  • [ISSN] 0091-3057
  • [Journal-full-title] Pharmacology, biochemistry, and behavior
  • [ISO-abbreviation] Pharmacol. Biochem. Behav.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetophenones; 0 / Anti-Anxiety Agents; 0 / Muscle Relaxants, Central; 3R834EPI82 / paeonol; Q3JTX2Q7TU / Diazepam
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81. Tejada J, Bosco GG, Morato S, Roque AC: Characterization of the rat exploratory behavior in the elevated plus-maze with Markov chains. J Neurosci Methods; 2010 Nov 30;193(2):288-95
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  • It consists of a plus-shaped maze with two open and two closed arms elevated 50cm from the floor.
  • The standard measures used to characterize exploratory behavior in the elevated plus-maze are the time spent and the number of entries in the open arms.
  • The spatial structure of the elevated plus-maze is divided into squares, which are associated with states of a Markov chain.
  • By counting the frequencies of transitions between states during 5-min sessions in the elevated plus-maze, we constructed stochastic matrices for the three conditions studied.
  • For the control group, the stochastic matrix shows a clear preference for places in the closed arms.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20869398.001).
  • [ISSN] 1872-678X
  • [Journal-full-title] Journal of neuroscience methods
  • [ISO-abbreviation] J. Neurosci. Methods
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Anxiety Agents; 0 / Convulsants; 6RZ6XEZ3CR / Chlordiazepoxide; WM5Z385K7T / Pentylenetetrazole
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82. Suzuki M, Tominaga N, Ide Y, Ohyama A, Nakahara T, Ishikawa H, Tanaka A, Mataga I: Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs. Hum Cell; 2010 May;23(2):65-73
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  • [Title] Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs.
  • Primary alveolar type of rhabdomyosarcoma (RMS) tumor tissue was collected from the tongue of a 17-year-old Japanese woman and used to successfully establish a rhabdomyosarcoma cell line, which has been designated NUTOS.
  • Histopathological observations of the NUTOS cell grafts in the subcutis of nude mice exhibited characteristics similar to those seen for the primary rhabdomyosarcoma of the tongue.
  • [MeSH-major] Drug Screening Assays, Antitumor. Rhabdomyosarcoma / pathology. Tongue Neoplasms / pathology


83. Ziari M, Sonpavde G, Shen S, Zhai J, Teh BS, Lerner SP: Patients with unusual bladder malignancies and a rare cause of splenomegaly. Case 2. Rhabdomyosarcoma of the urinary bladder in an adult. J Clin Oncol; 2005 Jul 1;23(19):4459-60
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  • [Title] Patients with unusual bladder malignancies and a rare cause of splenomegaly. Case 2. Rhabdomyosarcoma of the urinary bladder in an adult.
  • [MeSH-major] Rhabdomyosarcoma / diagnosis. Splenomegaly / etiology. Urinary Bladder Neoplasms / diagnosis

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  • (PMID = 15994156.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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84. Aravin AA, Hannon GJ, Brennecke J: The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science; 2007 Nov 2;318(5851):761-4
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  • [Title] The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.
  • As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history.

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  • (PMID = 17975059.001).
  • [ISSN] 1095-9203
  • [Journal-full-title] Science (New York, N.Y.)
  • [ISO-abbreviation] Science
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Argonaute Proteins; 0 / DNA Transposable Elements; 0 / Drosophila Proteins; 0 / Proteins; 0 / RNA, Small Interfering; 0 / RNA-Binding Proteins; 0 / RNA-Induced Silencing Complex; 0 / piwi protein, Drosophila
  • [Number-of-references] 38
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85. Huang P, Liu-Chen LY, Kirby LG: Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze. Neurosci Lett; 2010 May 21;475(3):165-8
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  • In contrast, SR141716 precipitated a reduction in exploration of the open arms of EPM in mice repeatedly treated with THC vs vehicle.
  • At 3.0mg/kg, SR141716 significantly reduced % open arm entries of the total arm entries, % open arm time of total time in arms, and the absolute time spent in open arms.

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  • [Copyright] Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
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  • (PMID = 20363293.001).
  • [ISSN] 1872-7972
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / P30DA013429; United States / NIDA NIH HHS / DA / P30 DA013429; United States / NIDA NIH HHS / DA / R01 DA17302; United States / NIMH NIH HHS / MH / K01 MH63301; United States / NIDA NIH HHS / DA / R01 DA017302; United States / NIMH NIH HHS / MH / K01 MH063301
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Piperidines; 0 / Psychotropic Drugs; 0 / Pyrazoles; 0 / Receptor, Cannabinoid, CB1; 158681-13-1 / rimonabant; 7J8897W37S / Dronabinol
  • [Other-IDs] NLM/ NIHMS199509; NLM/ PMC3923489
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86. Gomis M, González LM, Querol F, Gallach JE, Toca-Herrera JL: Effects of electrical stimulation on muscle trophism in patients with hemophilic arthropathy. Arch Phys Med Rehabil; 2009 Nov;90(11):1924-30
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  • INTERVENTIONS: The hemophilic group followed a surface electrical stimulation program (frequency 45 Hz, impulse 200 micros, 10s on/10s off) over an 8-week period on the biceps brachii of both arms.
  • MAIN OUTCOME MEASURES: The cross-sectional area, maximum voluntary isometric contraction, and EMG activity of the biceps brachii in both arms were determined before and after the 8-week-long task.
  • RESULTS: The results of the hemophilic group showed significant increases in the diameter (15.8%, P<.001), isometric force (4.6%, P<.05), and EMG activity (37.6%, P<.05) of the biceps brachii muscles in both arms.
  • In addition, these results may also be clinically applicable in the rehabilitation of patients who have similar deficiencies in the locomotor system.

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  • (PMID = 19887218.001).
  • [ISSN] 1532-821X
  • [Journal-full-title] Archives of physical medicine and rehabilitation
  • [ISO-abbreviation] Arch Phys Med Rehabil
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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87. Vianna LC, Oliveira RB, Ramos PS, Ricardo DR, Araújo CG: Effect of muscle mass on muscle mechanoreflex-mediated heart rate increase at the onset of dynamic exercise. Eur J Appl Physiol; 2010 Feb;108(3):429-34
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  • Fifteen healthy male subjects, 18-30 years old, performed, from the 4th to the 8th second of a 12-s apnea, four different 4-s bouts of passive cycling assigned in a counterbalanced order, each one different from the others by the number of limbs engaged in the movement (i.e., 1 arm, 2 arms, 2 arms + 1 leg and 2 arms + 2 legs), while respiratory movements and limb muscle electromyography were recorded.

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  • (PMID = 19821119.001).
  • [ISSN] 1439-6327
  • [Journal-full-title] European journal of applied physiology
  • [ISO-abbreviation] Eur. J. Appl. Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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88. Malyszko J, Zbroch E, Malyszko J, Mysliwiec M, Iaina A: The cardio-renal-anaemia syndrome predicts survival in peritoneally dialyzed patients. Arch Med Sci; 2010 Aug 30;6(4):539-44
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  • INTRODUCTION: Anaemia is one of the arms of the cardio-renal-anaemia syndrome (CRA) in chronic kidney disease (CKD) patients.
  • The severity score = cardiac + renal + anaemia arms score divided by 3 (maximum 4 points).

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  • (PMID = 22371797.001).
  • [ISSN] 1896-9151
  • [Journal-full-title] Archives of medical science : AMS
  • [ISO-abbreviation] Arch Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3284068
  • [Keywords] NOTNLM ; anaemia / chronic heart failure / diabetes / elderly / peritoneal dialysis
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89. Shimohama T, Ako J, Yamasaki M, Otake H, Tsujino I, Hasegawa T, Nakatani D, Sakurai R, Chang H, Kusano H, Waseda K, Honda Y, Stone GW, Saito S, Fitzgerald PJ, Sudhir K: SPIRIT III JAPAN versus SPIRIT III USA: a comparative intravascular ultrasound analysis of the everolimus-eluting stent. Am J Cardiol; 2010 Jul 1;106(1):13-7
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  • The aim of this study was to evaluate the vascular response after everolimus-eluting stent (EES) implantation in the SPIRIT III Japan Registry (JAPAN) compared to EES implantation in the SPIRIT III United States (USA) trial using serial intravascular ultrasound (IVUS) analysis.
  • Late acquired ISA was infrequent in the 2 arms.
  • In conclusion, comparative IVUS analysis between the JAPAN and USA arms showed more optimal stent deployment in the JAPAN arm as evidenced by the lower incidence of postprocedure ISA and larger minimum lumen area after the procedure.
  • [MeSH-major] Coronary Artery Disease / pathology. Coronary Artery Disease / ultrasonography. Drug-Eluting Stents. Randomized Controlled Trials as Topic
  • [MeSH-minor] Aged. Everolimus. Female. Humans. Hyperplasia / ultrasonography. Immunosuppressive Agents / administration & dosage. Japan. Male. Middle Aged. Sirolimus / administration & dosage. Sirolimus / analogs & derivatives. Ultrasonography, Interventional. United States

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20609640.001).
  • [ISSN] 1879-1913
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 9HW64Q8G6G / Everolimus; W36ZG6FT64 / Sirolimus
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90. Cohen MH, Justice R, Pazdur R: Approval summary: pemetrexed in the initial treatment of advanced/metastatic non-small cell lung cancer. Oncologist; 2009 Sep;14(9):930-5
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  • The median progression-free survival times were 4.8 and 5.1 months for the AC and GC arms, respectively (adjusted HR, 1.04; 95% CI, 0.94-1.15).
  • The overall response rates were 27.1% and 24.7% for the AC and GC arms, respectively.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols. Cisplatin / administration & dosage. Cisplatin / therapeutic use. Clinical Trials, Phase III as Topic. Deoxycytidine / administration & dosage. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Disease-Free Survival. Female. Humans. Male. Middle Aged. Pemetrexed. Survival Analysis. Time Factors. United States. United States Food and Drug Administration


91. Stinco G, Piccirillo F, Valent F: A randomized double-blind study to investigate the clinical efficacy of adding a non-migrating antimicrobial to a special silk fabric in the treatment of atopic dermatitis. Dermatology; 2008;217(3):191-5
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  • The inclusion criterion was that the patients presented with active AD with eczematous lesions located on the arms without any sign of infection.
  • RESULTS: The mean local SCORAD index of both the DermaSilk- and the unmodified-silk-covered arms decreased significantly between baseline (T0) and the end of study (T28).


92. De D, Dogra S, Saikia UN, Kanwar AJ: An unusual presentation of mucous membrane pemphigoid. Skinmed; 2008 Jan-Feb;7(1):45-7
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  • [Title] An unusual presentation of mucous membrane pemphigoid.
  • The disease had started as tense blisters associated with a burning sensation over the lower part of her back, gradually followed by involvement of her chest, upper part of her back, and arms.
  • Cutaneous examination revealed a few tense bullae on normal-looking skin over her abdomen (Figure 2 inset) and arms and areas of scarring at the site of healed lesions on her back.
  • Examination of the other mucosae did not reveal any abnormality.
  • Direct immunofluorescence of a biopsy specimen from perilesional skin revealed linear deposits of immunoglobulins M and G and of C3 at the dermoepidermal junction which was consistent with mucous membrane pemphigoid.
  • [MeSH-major] Pemphigoid, Benign Mucous Membrane / pathology

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  • (PMID = 18174805.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Dermatologic Agents; 8W5C518302 / Dapsone; 9PHQ9Y1OLM / Prednisolone
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93. Llombart-Cussac A, Martin M, Harbeck N, Anghel RM, Eniu AE, Verrill MW, Neven P, De Grève J, Melemed AS, Clark R, Simms L, Kaiser CJ, Ma D: A randomized, double-blind, phase II study of two doses of pemetrexed as first-line chemotherapy for advanced breast cancer. Clin Cancer Res; 2007 Jun 15;13(12):3652-9
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  • RESULTS: The P600 (47 patients) and P900 (45 patients) arms had response rates of 17.0% (95% confidence interval, 7.7-30.8%) and 15.6% (95% confidence interval, 6.5-29.5%) with approximately 50% stable disease per arm, median progression-free survival of 4.2 and 4.1 months, and median times to tumor progression of 4.2 and 4.6 months, respectively.
  • Both arms exhibited minimal toxicity (grade 3/4 neutropenia <20%, leukopenia <9%, and other toxicities <5%).

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  • (PMID = 17575230.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Biomarkers, Tumor; 0 / Glutamates; 0 / RNA, Messenger; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; 935E97BOY8 / Folic Acid; P6YC3EG204 / Vitamin B 12
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94. Lawton CA, DeSilvio M, Roach M 3rd, Uhl V, Kirsch R, Seider M, Rotman M, Jones C, Asbell S, Valicenti R, Hahn S, Thomas CR Jr: An update of the phase III trial comparing whole pelvic to prostate only radiotherapy and neoadjuvant to adjuvant total androgen suppression: updated analysis of RTOG 94-13, with emphasis on unexpected hormone/radiation interactions. Int J Radiat Oncol Biol Phys; 2007 Nov 1;69(3):646-55
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  • PURPOSE: This trial was designed to test the hypothesis that total androgen suppression and whole pelvic radiotherapy (WPRT) followed by a prostate boost improves progression-free survival (PFS) by > or =10% compared with total androgen suppression and prostate only RT (PORT).
  • This trial was also designed to test the hypothesis that neoadjuvant hormonal therapy (NHT) followed by concurrent total androgen suppression and RT improves PFS compared with RT followed by adjuvant hormonal therapy (AHT) by > or =10%.
  • Patients were stratified by T stage, prostate-specific antigen level, and Gleason score and were required to have an estimated risk of lymph node involvement of >15%.
  • RESULTS: The difference in overall survival for the four arms was statistically significant (p = 0.027).
  • A trend towards a difference was found in PFS (p = 0.065) in favor of the WPRT + NHT arm compared with the PORT + NHT and WPRT + AHT arms.
  • Four Phase III trials have demonstrated better outcomes when NHT was combined with RT compared with RT alone.
  • The Radiation Therapy Oncology Group 9413 trial results have demonstrated that when NHT is used in conjunction with RT, WPRT yields a better PFS than does PORT.

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  • (PMID = 17531401.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA096216-05S3; United States / NCI NIH HHS / CA / U56 CA096216; United States / NCI NIH HHS / CA / U56 CA096216-05S3
  • [Publication-type] Clinical Trial, Phase III; Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgen Antagonists; EC 3.4.21.77 / Prostate-Specific Antigen
  • [Other-IDs] NLM/ NIHMS31871; NLM/ PMC2917177
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95. Harris RZ, Salfi M, Sullivan JT, Padhi D: Pharmacokinetics of cinacalcet hydrochloride when administered with ketoconazole. Clin Pharmacokinet; 2007;46(6):495-501
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  • BACKGROUND AND OBJECTIVE: The calcimimetic cinacalcet hydrochloride (cinacalcet) is used for treatment of patients with chronic kidney disease with secondary hyperparathyroidism, a population that commonly receives multiple concurrent medications.
  • Pharmacokinetic parameters were analysed using a crossover ANOVA model that included subjects who completed both treatment arms.
  • RESULTS: Twenty subjects completed both treatment arms.
  • [MeSH-major] Antifungal Agents / pharmacology. Cytochrome P-450 Enzyme System / metabolism. Ketoconazole / pharmacology. Naphthalenes / pharmacokinetics

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  • (PMID = 17518508.001).
  • [ISSN] 0312-5963
  • [Journal-full-title] Clinical pharmacokinetics
  • [ISO-abbreviation] Clin Pharmacokinet
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Naphthalenes; 1K860WSG25 / Cinacalcet Hydrochloride; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.14.13.67 / CYP3A4 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP3A; R9400W927I / Ketoconazole; SY7Q814VUP / Calcium
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96. Southwest Oncology Group, Berry DL, Moinpour CM, Jiang CS, Ankerst DP, Petrylak DP, Vinson LV, Lara PN, Jones S, Taplin ME, Burch PA, Hussain MH, Crawford ED: Quality of life and pain in advanced stage prostate cancer: results of a Southwest Oncology Group randomized trial comparing docetaxel and estramustine to mitoxantrone and prednisone. J Clin Oncol; 2006 Jun 20;24(18):2828-35
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  • While Southwest Oncology Group trial 99-16 demonstrated a survival improvement of DE over MP, the study also was designed to compare the palliation of disease-related symptoms.
  • There were no statistically significant differences in pain palliation between the treatment arms.
  • The sensitivity analyses showed a consistent lack of statistically significant global QOL differences for the two arms.


97. Valmaggia LR, Freeman D, Green C, Garety P, Swapp D, Antley A, Prescott C, Fowler D, Kuipers E, Bebbington P, Slater M, Broome M, McGuire PK: Virtual reality and paranoid ideations in people with an 'at-risk mental state' for psychosis. Br J Psychiatry Suppl; 2007 Dec;51:s63-8
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  • [Title] Virtual reality and paranoid ideations in people with an 'at-risk mental state' for psychosis.
  • AIMS: To establish the feasibility and safety of using virtual reality methodology in people with an at-risk mental state and to investigate the applicability of a cognitive model of paranoia to this group.
  • METHOD: Twenty-one participants with an at-risk mental state were assessed before and after entering a virtual reality environment depicting the inside of an underground train.
  • Individuals attributed mental states to virtual reality characters including hostile intent.
  • CONCLUSIONS: Virtual reality is an acceptable experimental technique for use with individuals with at-risk mental states.

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  • (PMID = 18055940.001).
  • [ISSN] 0960-5371
  • [Journal-full-title] The British journal of psychiatry. Supplement
  • [ISO-abbreviation] Br J Psychiatry Suppl
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 062452
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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98. Duerkop BA, Vaishnava S, Hooper LV: Immune responses to the microbiota at the intestinal mucosal surface. Immunity; 2009 Sep 18;31(3):368-76
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  • Here we discuss recent insights into how the innate and adaptive arms of the immune system collaborate to maintain homeostasis at the luminal surface of the intestinal host-microbial interface.
  • These findings are also yielding a better understanding of how symbiotic host-microbial relationships can break down in inflammatory bowel disease.

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  • (PMID = 19766080.001).
  • [ISSN] 1097-4180
  • [Journal-full-title] Immunity
  • [ISO-abbreviation] Immunity
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 84
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99. Vaishnavi S, Gadde K, Alamy S, Zhang W, Connor K, Davidson JR: Modafinil for atypical depression: effects of open-label and double-blind discontinuation treatment. J Clin Psychopharmacol; 2006 Aug;26(4):373-8
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  • Atypical depression, with features of hypersomnia, hyperphagia, anergia, and rejection sensitivity, is a common presentation of major depressive disorder.
  • There are few available effective therapies for this disorder.
  • We found that modafinil significantly improved atypical depression symptoms during 12 weeks of open-label treatment (mean +/- SD Hamilton Depression Scale (29-item version) score changed from 34 +/- 8.2 at baseline to 9.7 +/- 9.3, P < 0.0001), and that benefits were maintained alike in both the continuation and placebo arms during the double-blind treatment phase (P = 0.92).
  • [MeSH-major] Benzhydryl Compounds / therapeutic use. Depressive Disorder / drug therapy
  • [MeSH-minor] Adult. Aged. Central Nervous System Stimulants / administration & dosage. Central Nervous System Stimulants / adverse effects. Central Nervous System Stimulants / therapeutic use. Disorders of Excessive Somnolence / drug therapy. Double-Blind Method. Female. Headache / chemically induced. Humans. Hyperphagia / drug therapy. Male. Middle Aged. Nausea / chemically induced. Patient Dropouts. Patient Selection. Thirst / drug effects. Time Factors. Treatment Outcome. Weight Loss / drug effects. Withholding Treatment

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  • [ErratumIn] J Clin Psychopharmacol. 2006 Oct;26(5):523
  • (PMID = 16855454.001).
  • [ISSN] 0271-0749
  • [Journal-full-title] Journal of clinical psychopharmacology
  • [ISO-abbreviation] J Clin Psychopharmacol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Central Nervous System Stimulants; R3UK8X3U3D / modafinil
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100. Lalonde R, Kim HD, Maxwell JA, Fukuchi K: Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques. Neurosci Lett; 2005 Dec 23;390(2):87-92
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  • On the initial testing day, 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice spent more time than non-transgenic controls in the open arms of the elevated plus-maze.

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  • (PMID = 16169151.001).
  • [ISSN] 0304-3940
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS43947
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Amyloid beta-Protein Precursor
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