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1. National Toxicology Program: NTP report on the toxicology studies of dichloroacetic acid (CAS No. 79-43-6) in genetically modified (FVB Tg.AC hemizygous) mice (dermal and drinking water studies) and carcinogenicity studies of dichloroacetic acid in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water studies). Natl Toxicol Program Genet Modif Model Rep; 2007 Apr;(11):1-168
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The NTP has explored the use of genetically altered mouse models as adjuncts to 2-year rodent cancer assays.
  • As part of the evaluation of new mouse cancer screening models, dichloroacetic acid was tested for potential toxicity and carcinogenicity in two relatively well-studied models, the Tg.AC hemizygous strain and the p53 haploinsufficient strain.
  • At the site of application, the incidences of squamous cell papilloma were significantly increased in 500 mg/kg males and females at 39 weeks.
  • In addition, one 125 mg/kg male, two 500 mg/kg males, and two 500 mg/kg females had squamous cell papillomas at 26 weeks.
  • At 26 weeks, a pulmonary carcinoma was found in one 1,000 mg/L male, one 500 mg/L female, and one 2,000 mg/L female.
  • Under the conditions of these dermal studies, there were increased incidences of squamous cell papillomas at the site of application in male and female Tg.AC hemizygous mice exposed to 500 mg/kg for 39 weeks.
  • Under the conditions of these drinking water studies, there was an increase in the incidence of alveolar/bronchiolar adenoma in male Tg.AC hemizygous mice exposed to 1,000 mg/L for 41 weeks.
  • There were a few bronchiolar/alveolar carcinomas in males and females exposed to dichloroacetic acid in the drinking water for 26 weeks and a few bronchiolar/alveolar adenomas in females exposed to dichloroacetic acid in the drinking water for 41 weeks.
  • The marginally increased incidences of pulmonary adenomas and/or carcinomas compared to the unexposed groups found in both the dermal and drinking water studies at 39 or 41 weeks were considered to be related to dichloroacetic acid exposure.
  • [MeSH-major] Adenoma / chemically induced. Carcinoma / chemically induced. Dichloroacetic Acid / toxicity. Lung Neoplasms / chemically induced. Papilloma / chemically induced. Skin Neoplasms / chemically induced. Water Pollutants, Chemical / toxicity

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  • (PMID = 18784768.001).
  • [ISSN] 1556-5246
  • [Journal-full-title] National Toxicology Program genetically modified model report
  • [ISO-abbreviation] Natl Toxicol Program Genet Modif Model Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; 0 / Water Pollutants, Chemical; 9LSH52S3LQ / Dichloroacetic Acid
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2. Nag S, Saraswathi TR, Sekhar G, Einstein A, Sivapathasundharam B: A rare case of sarcoid-like reaction of lymph nodes associated with squamous cell carcinoma of alveolar mucosa. Indian J Dent Res; 2009 Oct-Dec;20(4):503-5
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  • [Title] A rare case of sarcoid-like reaction of lymph nodes associated with squamous cell carcinoma of alveolar mucosa.
  • Non-necrotizing granulomas are occasionally seen in patients with certain malignant disorders and are termed as "sarcoid-like reaction," which have many similarities with sarcoidosis.
  • Sarcoidosis is a multisystem granulomatous disease of unknown etiology characterized by organ involvement and interference of organ function by granuloma or fibrosis.
  • Sarcoidosis is occasionally found in a variety of malignant diseases with an overall incidence of 4.4% in carcinoma patients.
  • We present here a rare case of moderately differentiated squamous cell carcinoma of alveolar mucosa with regard to mandible associated with sarcoid-like reaction of cervical lymph nodes in a female patient in the absence of clinical evidence of systemic sarcoidosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lymphatic Diseases / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Sarcoidosis / pathology

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  • (PMID = 20139581.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 10
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3. Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK: BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models. J Thorac Oncol; 2006 Nov;1(9 Suppl):S2-7
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  • [Title] BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.
  • INTRODUCTION: Human bronchioloalveolar carcinoma (BAC) is a disease with an evolving definition.
  • "Pure" BAC, characterized by a bronchioloalveolar growth pattern and no evidence of stromal, vascular, or pleural invasion, represents only 2 to 6% of non-small cell lung cancer (NSCLC) cases, but up to 20% of NSCLC cases may contain elements of BAC.
  • However, because BAC appears to behave clinically differently from adenocarcinoma, a better understanding of this disease entity is imperative.
  • METHODS/RESULTS: At the BAC Consensus Conference in 2004, our committee discussed issues relevant to BAC epidemiology, pathogenesis, and preclinical models.
  • CONCLUSIONS: Elucidation of molecular events involved in BAC tumorigenesis will allow for more precise epidemiologic studies and improved animal models, which will enable development of more effective treatments against the disease.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / epidemiology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / epidemiology. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenocarcinoma / physiopathology. Animals. Biopsy, Needle. Diagnosis, Differential. Disease Models, Animal. Female. Humans. Immunohistochemistry. Male. Mice. Mice, Nude. Mice, Transgenic. Neoplasm Staging. Prevalence. Prognosis. Risk Assessment. Sheep

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  • [ErratumIn] J Thorac Oncol. 2007 Jan;2(1):11. Kim, Kwok [corrected to Wong, Kwok-Kin]
  • (PMID = 17409996.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 074386; United States / NCI NIH HHS / CA / CA 092824; United States / NCI NIH HHS / CA / CA 0940578; United States / NCI NIH HHS / CA / CA 59116; United States / NIA NIH HHS / AG / K08AG 2400401
  • [Publication-type] Consensus Development Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Number-of-references] 79
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4. Osoegawa K, Vessere GM, Li Shu C, Hoskins RA, Abad JP, de Pablos B, Villasante A, de Jong PJ: BAC clones generated from sheared DNA. Genomics; 2007 Feb;89(2):291-9
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  • [Title] BAC clones generated from sheared DNA.
  • BAC libraries generated from restriction-digested genomic DNA display representational bias and lack some sequences.
  • To facilitate completion of genome projects, procedures have been developed to create BACs from DNA physically sheared to create fragments extending up to 200 kb.
  • The DNA fragments were repaired to create blunt ends and ligated to a new BAC vector.
  • This approach has been tested by generating BAC libraries from Drosophila DNA with insert lengths between 50 and 150 kb.
  • The libraries lack chimeric clone problems as determined by mapping paired BAC-end sequences to the assembled fly genome sequence.
  • The utility of "sheared" libraries was demonstrated by closure of a previous clone gap and by isolation of clones from telomeric regions, which were notably absent from previous Drosophila BAC libraries.

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  • (PMID = 17098394.001).
  • [ISSN] 0888-7543
  • [Journal-full-title] Genomics
  • [ISO-abbreviation] Genomics
  • [Language] ENG
  • [Grant] United States / NHGRI NIH HHS / HG / HG000750-07; United States / NHGRI NIH HHS / HG / HG00750; United States / NHGRI NIH HHS / HG / P50 HG000750-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
  • [Other-IDs] NLM/ NIHMS16521; NLM/ PMC1909752
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5. Suster ML, Sumiyama K, Kawakami K: Transposon-mediated BAC transgenesis in zebrafish and mice. BMC Genomics; 2009;10:477
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  • [Title] Transposon-mediated BAC transgenesis in zebrafish and mice.
  • BACKGROUND: Bacterial artificial chromosomes (BACs) are among the most widely used tools for studies of gene regulation and function in model vertebrates, yet methods for predictable delivery of BAC transgenes to the genome are currently limited.
  • This is because BAC transgenes are usually microinjected as naked DNA into fertilized eggs and are known to integrate as multi-copy concatamers in the genome.
  • Although conventional methods for BAC transgenesis have been very fruitful, complementary methods for generating single copy BAC integrations would be desirable for many applications.
  • RESULTS: We took advantage of the precise cut-and-paste behavior of a natural transposon, Tol2, to develop a new method for BAC transgenesis.
  • In this new method, the minimal sequences of the Tol2 transposon were used to deliver precisely single copies of a approximately 70 kb BAC transgene to the zebrafish and mouse genomes.
  • We mapped the BAC insertion sites in the genome by standard PCR methods and confirmed transposase-mediated integrations.
  • CONCLUSION: The Tol2 transposon has a surprisingly large cargo capacity that can be harnessed for BAC transgenesis.
  • The precise delivery of single-copy BAC transgenes by Tol2 represents a useful complement to conventional BAC transgenesis, and could aid greatly in the production of transgenic fish and mice for genomics projects, especially those in which single-copy integrations are desired.
  • [MeSH-major] Chromosomes, Artificial, Bacterial. DNA Transposable Elements. Gene Transfer Techniques. Zebrafish / genetics

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  • (PMID = 19832998.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Transposable Elements
  • [Other-IDs] NLM/ PMC2768751
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6. Todesco S, Campagna D, Levorin F, D'Angelo M, Schiavon R, Valle G, Vezzi A: PABS: an online platform to assist BAC-by-BAC sequencing projects. Biotechniques; 2008 Jan;44(1):60, 62, 64

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  • [Title] PABS: an online platform to assist BAC-by-BAC sequencing projects.
  • Genome sequencing projects are either based on whole genome shotgun (WGS) or on a BAC-by-BAC strategy.
  • Although WGS is in most cases the preferred choice, sometimes the BAC-by-BAC approach may be better because it requires a much simpler assembly process.
  • Furthermore, when the study is limited to specific regions of the genome, the WGS would require an unjustified effort, making the BAC-by-BAC the only feasible strategy.
  • In this paper we describe an informatics pipeline called PABS (Platform Assisted BAC-by-BAC Sequencing) that we developed to provide a tool to optimize the BAC-by-BAC sequencing strategy.
  • PABS has two main functions: (i) PABS-Select, to choose suitable overlapping clones; and (ii) PABS-Validate, to verify whether a BAC under analysis is actually overlapping the neighboring BAC.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Computational Biology / methods. Internet. Sequence Analysis, DNA / methods

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  • (PMID = 18254380.001).
  • [ISSN] 0736-6205
  • [Journal-full-title] BioTechniques
  • [ISO-abbreviation] BioTechniques
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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7. Wislez M, Antoine M, Rabbe N, Gounant V, Poulot V, Lavolé A, Fleury-Feith J, Cadranel J: Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features. Clin Cancer Res; 2007 Jun 15;13(12):3518-27
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  • [Title] Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features.
  • PURPOSE: Adenocarcinoma with bronchioloalveolar carcinoma (BAC) features is a subtype of non-small cell lung cancers characterized by an intense inflammatory reaction composed of macrophages and neutrophils and by a distinct natural history with intrapulmonary spread leading to death due to respiratory failure.
  • We hypothesized that neutrophils could promote aerogenous spread of lung adenocarcinoma with BAC features.
  • EXPERIMENTAL DESIGN: We examined the effect of neutrophils on A549 cell line detachment in vitro and we quantified desquamation of tumor cells on tumor tissue (n = 25) and on matched bronchioloalveolar lavage (n = 17) in vivo in a series of patients with adenocarcinoma with BAC features.
  • RESULTS: Neutrophils induced A549 detachment mediated by signals through cell-to-cell contact.
  • Neutralization studies identified several membrane-bound molecules involved in detachment (i.e., intercellular adhesion molecule-1/lymphocyte function-associated antigen-1, tumor necrosis factor alpha/tumor necrosis factor alpha receptor inhibitor, interleukin-1alpha /interleukin-1alpha receptor, and neutrophil elastase).
  • The micropapillary score was associated with a high neutrophil count in bronchioloalveolar lavage (P = 0.051).
  • The shedding cell percentage was a significant factor in shorter survival (P = 0.034, univariate Cox analysis).
  • It is a significant factor of shorter survival and may be an important event in adenocarcinoma progression.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / pathology. Neoplasm Invasiveness / pathology. Neutrophils / metabolism
  • [MeSH-minor] Cell Adhesion / physiology. Cell Communication / physiology. Cell Line, Tumor. Cell Proliferation. Coculture Techniques. Female. Flow Cytometry. Humans. Immunohistochemistry. Male

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  • (PMID = 17575214.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. Righi L, Sapino A, Marchiò C, Papotti M, Bussolati G: Neuroendocrine differentiation in breast cancer: established facts and unresolved problems. Semin Diagn Pathol; 2010 Feb;27(1):69-76
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  • [Title] Neuroendocrine differentiation in breast cancer: established facts and unresolved problems.
  • Neuroendocrine breast carcinoma (NEBC) diagnosis relies on (i) presence of morphologic neuroendocrine features, and (ii) neuroendocrine markers expressed in more than 50% of tumor cells.
  • The World Health Organization classification describes 3 main histologic types: the solid, the small/oat cell, and the large cell variant.
  • In addition, we have recently proposed a further categorization into 5 subgroups: the first 3 categories encompass solid lesions and include (i) solid cohesive carcinomas, (ii) alveolar carcinomas, and (iii) small cell carcinoma; the last subgroups include mucin-producing tumors which are (iv) solid papillary carcinomas and (v) cellular mucinous carcinomas.
  • Moreover, it has been demonstrated that mucinous and neuroendocrine carcinomas are transcriptionally distinct from conventional invasive ductal carcinomas.
  • Following the above criteria, NEBCs constitute approximately 1% of all breast carcinomas.
  • The clinical effect of neuroendocrine breast cancer is still a matter of debate; however, when compared with unselected breast cancers, NEBCs show a less aggressive clinical behavior.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Neuroendocrine / pathology
  • [MeSH-minor] Adenocarcinoma, Mucinous / pathology. Biomarkers, Tumor / metabolism. Carcinoma, Ductal, Breast / pathology. Cell Transformation, Neoplastic. Chromogranin A / metabolism. DNA, Neoplasm / analysis. Diagnosis, Differential. Female. Gene Expression Profiling. Humans. Synaptophysin / metabolism

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  • (PMID = 20306832.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranin A; 0 / DNA, Neoplasm; 0 / Synaptophysin
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9. Hahn FF, Gigliotti AP, Hutt JA, March TH, Mauderly JL: A review of the histopathology of cigarette smoke-induced lung cancer in rats and mice. Int J Toxicol; 2007 Jul-Aug;26(4):307-13
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  • [Title] A review of the histopathology of cigarette smoke-induced lung cancer in rats and mice.
  • In the past several years an increased number of lung tumors has been reported in laboratory studies of rats and mice after lifetime exposure to mainstream cigarette smoke.
  • Proliferative epithelial lesions are present in the lungs of both species and are apparent antecedent lesions to benign and malignant tumors.
  • Both species have alveolar epithelia hyperplasia, alveolar adenomas, and alveolar carcinomas.
  • In addition, mice also have bronchiolar epithelial hyperplasia and bronchial papillomas not found in rats.
  • Lung tumors in rats and mice are found at the end of the life span and rarely metastasize.
  • The characteristics of the lung tumors, and the proliferative changes associated with the tumors, are important in helping understand the mechanisms of lung cancer induction.
  • These studies in rats and mice allow new approaches to the study of cigarette smoke-induced changes in the lung.
  • [MeSH-major] Adenocarcinoma / etiology. Adenoma / etiology. Lung Neoplasms / etiology. Precancerous Conditions / etiology. Pulmonary Alveoli / drug effects. Smoking / adverse effects
  • [MeSH-minor] Administration, Inhalation. Animals. Bronchi / drug effects. Bronchi / pathology. Bronchial Neoplasms / etiology. Bronchial Neoplasms / pathology. Disease Models, Animal. Female. Male. Mice. Mice, Inbred Strains. Papilloma / etiology. Papilloma / pathology. Rats. Rats, Inbred F344. Respiratory Mucosa / drug effects. Respiratory Mucosa / pathology. Species Specificity

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  • (PMID = 17661221.001).
  • [ISSN] 1091-5818
  • [Journal-full-title] International journal of toxicology
  • [ISO-abbreviation] Int. J. Toxicol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Chatterji B, Borlak J: A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice. Proteomics; 2009 Feb;9(4):1044-56
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  • [Title] A 2-DE MALDI-TOF study to identify disease regulated serum proteins in lung cancer of c-myc transgenic mice.
  • We previously reported targeted overexpression of c-myc to alveolar epithelium to cause lung cancer.
  • Proteins were extracted with a thiourea-containing lysis buffer and separated by 2-DE at pH 4-7 and 3-10 followed by MALDI-TOF/TOF analysis.
  • This included disease regulated expression of orosomucoid-8, alpha-2-macroglobulin, apolipoprotein-A1, apolipoprotein-C3, glutathione peroxidase-3, plasma retinol-binding protein, and transthyretin, while expression of apolipoprotein-E was decreased at late stages of disease.
  • Moreover, serum amyloid P component was uniquely expressed at late stages of cancer.
  • It is of considerable importance that most disease regulated proteins carried the E-Box sequence (CACGTG) in the promoter of the coding gene, therefore providing evidence for their regulation by c-myc.
  • Notably, expression of alpha-2-macroglobulin, transthyretin, alpha-1-antitrypsin, and properdin was in common in different lung tumor models, but regulation of orosomucoid-8, apolipoprotein-A1, apolipoprotein-C3, apolipoprotein-E, glutathione peroxidase-3, plasma retinol-binding protein, and serum amyloid P component was unique when the serum proteomes of c-myc and c-raf tumor bearing mice were compared.
  • Therefore, candidate biomarkers to differentiate between atypical adenomatous hyperplasias (AAH) and bronchiolo-alveolar carcinomas (BAC)/papillary adenocarcinomas (PLAC) can be proposed.
  • [MeSH-major] Acute-Phase Proteins / metabolism. Blood Proteins / metabolism. Gene Expression Regulation, Neoplastic. Lung Neoplasms / metabolism. Proto-Oncogene Proteins c-myc / metabolism
  • [MeSH-minor] Animals. Apolipoproteins / genetics. Apolipoproteins / metabolism. Biomarkers / metabolism. Disease Models, Animal. E-Box Elements / genetics. Electrophoresis, Gel, Two-Dimensional. Glutathione Peroxidase / genetics. Glutathione Peroxidase / metabolism. Lung / pathology. Mice. Mice, Transgenic. Normal Distribution. Proto-Oncogene Proteins c-raf / genetics. Proto-Oncogene Proteins c-raf / metabolism. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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  • (PMID = 19180532.001).
  • [ISSN] 1615-9861
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Acute-Phase Proteins; 0 / Apolipoproteins; 0 / Biomarkers; 0 / Blood Proteins; 0 / Myc protein, mouse; 0 / Proto-Oncogene Proteins c-myc; EC 1.11.1.- / Gpx3 protein, mouse; EC 1.11.1.9 / Glutathione Peroxidase; EC 2.7.11.1 / Proto-Oncogene Proteins c-raf
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11. Koyama H, Ohno Y, Aoyama N, Onishi Y, Matsumoto K, Nogami M, Takenaka D, Nishio W, Ohbayashi C, Sugimura K: Comparison of STIR turbo SE imaging and diffusion-weighted imaging of the lung: capability for detection and subtype classification of pulmonary adenocarcinomas. Eur Radiol; 2010 Apr;20(4):790-800
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of STIR turbo SE imaging and diffusion-weighted imaging of the lung: capability for detection and subtype classification of pulmonary adenocarcinomas.
  • OBJECTIVE: The aim of the study was to evaluate the diagnostic performance of diffusion-weighted imaging (DWI) for detection and subtype classification in pulmonary adenocarcinomas through comparison with short TI inversion recovery turbo spin-echo imaging sequence (STIR).
  • METHODS: Thirty-two patients (mean age, 65.2 years) with 33 adenocarcinomas (mean diameter, 27.6 mm) were enrolled in this study.
  • The ADC values on DWI and the contrast ratio (CR) between cancer and muscle on STIR were measured and those were compared across subtype classifications.
  • The ADC values showed no significant difference regarding subtype classification; however, the CRs of bronchio-alveolar carcinomas (BACs) were significantly lower than those of other types (P < 0.05).
  • When threshold values for differentiating BACs from others were adapted, the sensitivity and accuracy of DWI were significantly lower than those of STIR (P < 0.05).
  • For differentiating adenocarcinomas with mixed subtypes from those with no BA component, there were no significant differences between the two sequences.
  • [MeSH-major] Adenocarcinoma / diagnosis. Algorithms. Diffusion Magnetic Resonance Imaging / methods. Image Interpretation, Computer-Assisted / methods. Lung / pathology. Lung Neoplasms / diagnosis

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  • (PMID = 19763578.001).
  • [ISSN] 1432-1084
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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12. Guard O: [BAC 40 battery: a tool of cognitive evaluation for the diagnosis of Alzheimer's disease at the specialist office]. Rev Neurol (Paris); 2010 Jun-Jul;166(6-7):615-20
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  • [Title] [BAC 40 battery: a tool of cognitive evaluation for the diagnosis of Alzheimer's disease at the specialist office].
  • [Transliterated title] La batterie BAC 40: un outil d'évaluation cognitive pour le diagnostic de la maladie d'Alzheimer au cabinet du spécialiste.
  • BAC 40 is a "composite" battery of psychometric tests useful for the diagnosis of Alzheimer's dementia.
  • The advantage is to establish a diagnosis in less than 20 minutes, exploring all the sectors of cognitive life.
  • The scores obtained with "BAC 40" and the "ADAS-COG SCALE" were compared in all patients.
  • [MeSH-major] Alzheimer Disease / diagnosis. Neuropsychological Tests

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  • (PMID = 20149920.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Validation Studies
  • [Publication-country] France
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13. Kim TH, Kim SJ, Ryu YH, Chung SY, Seo JS, Kim YJ, Choi BW, Lee SH, Cho SH: Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia. Eur Radiol; 2006 Aug;16(8):1763-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia.
  • The purpose of this study was to evaluate retrospectively the differential CT features of bronchioloalveolar carcinoma (BAC) mimicking pneumonia and infectious pneumonia at the lung periphery.
  • CT images were reviewed in 47 patients with focal areas of parenchymal opacification at the lung periphery.
  • We evaluated the presence of ground-glass attenuation, marginal conspicuity of the lesion, CT angiogram sign, air-bronchogram sign, a bubble-like low-attenuation area within the lesion, presence of pleural thickening and retraction associated with the lesion, presence of pleural effusion and extra-pleural fatty hypertrophy, presence of bronchial wall thickening proximal to the lesion, and air-trapping in the normal lung near the lesion.
  • BAC (n=18) depicted the presence of a bubble-like low-attenuation area within the lesion, whereas infectious pneumonia (n=29) represented the pleural thickening associated with the lesion and bronchial wall thickening proximal to the lesion (P<0.05).
  • The focal areas of the parenchymal opacification on the CT images may suggest infectious pneumonia rather than BAC when they show bronchial wall thickening proximal to the lesion and pleural thickening associated with the lesion, whereas BAC is characterized as the presence of a bubble-like low attenuation area within the tumor.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Pneumonia / radiography. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Radiography, Thoracic. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16418864.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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14. Travis WD, Garg K, Franklin WA, Wistuba II, Sabloff B, Noguchi M, Kakinuma R, Zakowski M, Ginsberg M, Padera R, Jacobson F, Johnson BE, Hirsch F, Brambilla E, Flieder DB, Geisinger KR, Thunnisen F, Kerr K, Yankelevitz D, Franks TJ, Galvin JR, Henderson DW, Nicholson AG, Hasleton PS, Roggli V, Tsao MS, Cappuzzo F, Vazquez M: Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol; 2005 May 10;23(14):3279-87
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  • [Title] Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.
  • PURPOSE: To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC).
  • METHODS: A pathology/CT review panel of pathologists and radiologists met during a November 2004 International Association for the Study of Lung Cancer/American Society of Clinical Oncology consensus workshop in New York.
  • The purpose was to determine if existing data was sufficient to propose modification of criteria for adenocarcinoma and BAC as newly published in the 2004 WHO Classification of Lung Tumors, and to address the pathologic/radiologic concept of diffuse/multicentric BAC.
  • RESULTS: Solitary small, peripheral BACs have an excellent prognosis.
  • Most lung adenocarcinomas with a BAC pattern are not pure BAC, but rather adenocarcinoma, mixed subtype with invasive patterns.
  • The percent of BAC versus invasive components in lung adenocarcinomas appears to be prognostically important.
  • However, a consensus definition of "minimally invasive" BAC with a favorable prognosis could not be achieved.
  • While recognition of a BAC component is possible, the diagnosis of BAC with exclusion of invasive adenocarcinoma cannot be made by small biopsy or cytology specimens.
  • CONCLUSION: There is a need to work toward a mutual understanding and consensus between pathologists, clinicians, and researchers with the use of the term BAC versus adenocarcinoma.
  • Hopefully, this work will allow definition of a category of adenocarcinoma, mixed subtype with predominant BAC/minimal invasion and a favorable prognosis.
  • [MeSH-major] Adenocarcinoma / radiography. Lung Neoplasms / radiography
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Humans. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 15886315.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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15. Quesenberry PJ, Del Tatto M, Berz D, Miner T, Ng T, Winer ES, Aliotta J, Colvin G, Dooner M, Dooner G, Fontaine JP: Marrow cell genetic phenotype change induced by human lung cancer cells. J Clin Oncol; 2009 May 20;27(15_suppl):11108

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Marrow cell genetic phenotype change induced by human lung cancer cells.
  • : 11108 Background: Murine lung-derived microvesicles are capable of inducing lung-specific mRNA in marrow cells, when co-cultured across from these cells, but separated from them by a cell-impermeable (0.4 micron) membrane.
  • These converted murine marrow cells showed mRNA elevations, lung-specific protein production and enhanced capacity to convert to lung epithelial cells after in vivo transplantation into irradiated mice.
  • We examine here whether fresh tissue from lung cancer patients would have the same capacity to genetically alter co-cultured human marrow cells.
  • METHODS: Lung cancer samples were collected from 5 patients undergoing surgery.
  • Marrow cell RNA was analyzed for lung specific mRNA using real time RT-PCR.
  • RESULTS: Lung cancers studied were adenocarcinoma, endobronchial alveolar carcinoma, bronchioloalveolar carcinoma, non-small cell carcinoma and squamous cell carcinoma. mRNAs for aquaporin 1-5, specific for type I pneumocytes and surfactant A-D, specific for type II pneumocytes, were measured.
  • Aquaporin I was elevated in marrow cells from co culture with all lung cancers; elevations ranging from 2.15 to 56.7 fold (mean 23 fold).
  • Similarly surfactant B mRNA was induced in marrow cells by all lung cancers with fold elevations ranging from 7.9 to 2164 (mean fold elevation 668).
  • CONCLUSIONS: These observations indicate that the genetic phenotype of cells in the vicinity of lung cancer cells can be altered and that these alterations might be mediated by microvesicle transfer of genetic information.

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  • (PMID = 27963460.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Pejovic T, Gaile DP, Darcy KM, Liu S, Shepherd L, Rodgers WH, Kohn E, Mannel R, Birrer MJ, Nowak N: A Gynecologic Oncology Group study of frequent copy number aberrations in DNA repair genes and other genomic regions in stage I serous ovarian cancers. J Clin Oncol; 2009 May 20;27(15_suppl):e16504

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RPCI 19K BAC arrays were hybridized (GeneTAC HybStation) and scanned (Gene Pix 4200AL Laser Scanner).
  • RESULTS: Several genes associated with the Fanconi DNA-damage response pathway were frequently altered in stage I serous ovarian carcinomas.
  • Frequent genomic losses and gains were observed in DNA repair genes and other genomic regions in stage I serous ovarian cancer which may promote genomic instability, resistance, metastasis and aggressiveness of this disease.

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  • (PMID = 27960763.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Laskin JJ, Pugh T, Jackson C, Sutcliffe M, Ionescu D, Melosky B, Ho C, Sun S, Murray N, Marra M: Transcriptome-wide mutation discovery in patients in a phase II clinical trial of first-line erlotinib for clinically selected patients with advanced non-small cell lung cancer. J Clin Oncol; 2009 May 20;27(15_suppl):8102

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcriptome-wide mutation discovery in patients in a phase II clinical trial of first-line erlotinib for clinically selected patients with advanced non-small cell lung cancer.
  • METHODS: Treatment was erlotinib 150 mg p.o. daily until disease progression.
  • Eligibility criteria included: stage IIIB/IV NSCLC; no prior chemo; ECOG ≤2; at least 2 of the following 4 criteria: women, never-smokers, Southeast Asian origin, adenocarcinoma and/or BAC.
  • Pathology: 44 ACA; 3 BAC;1 squamous carcinoma; 13 NSCLC NOS.
  • The discovery of novel mutations in multiple pts suggests patterns that may shed light on lung cancer specific behaviour.

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  • (PMID = 27964273.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Zhong W, Yang X, Guo A, Su J, Zhang X, Chen H, Qiao G, Liao R, Yang J, Wu Y: Genetic evolution of EGFR and the clonal origin of adenocarcinomas exhibiting various degrees of bronchioloalveolar carcinoma. J Clin Oncol; 2009 May 20;27(15_suppl):e22050

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genetic evolution of EGFR and the clonal origin of adenocarcinomas exhibiting various degrees of bronchioloalveolar carcinoma.
  • : e22050 Background: EGFR mutations may accumulate during multistage progression of bronchioloalveolar carcinoma (BAC), leading to heterogeneity within the tumor.
  • Moreover, intrapulmonary emersions are the predominant sites of BAC progression in the absence of other distant metastases.
  • In cases of emerging bilateral lung lesions during the follow-up to complete resection, the issue of how to differentiate between lesions originating from multifocal BACs or distant metastases/local recurrence is an important and unresolved issue.
  • This study was performed to determine whether sequential adenocarcinoma with BAC features emerges in the lung field arises from a single clone or multiple clones in the same individual.
  • METHODS: Samples of adenocarcinomas exhibiting various degrees of BAC were obtained by thoracotomy.
  • Sequential specimens were obtained on detection of novel lesions in the lung field.
  • Our pathological findings, sequential imaging, and EGFR sequence data were compared to monitor evidence of cancer evolution.
  • RESULTS: Based on an analysis of EGFR in tumor specimens from 428 lung cancer patients, fifteen cases of sequential BAC-related adenocarcinoma obtained by thoracotomy were identified.
  • Together with alterations in BAC/adenocarcinoma components, the EGFR-TKI untreated series with at least one episode of EGFR-activating mutations represented three typical models: no significant EGFR evolution for a single clone, genetic alterations from mutant to wild-type EGFR for multifocal lesions, and a switch from wild-type to mutant EGFR, which might exhibit uncertain circumstances of cancer progression.
  • CONCLUSIONS: Genetic analysis in conjunction with pathological and radiological diagnoses can be used to explore the origin of multifocal BAC.
  • The single clone model indicates subsequent disease progression, whereas genetic alterations from mutations to wild-type EGFR are suggestive of secondary primary carcinoma.
  • When additional lesions emerge after radical resection of BAC-related lung cancer, sequential tumor samples should be obtained for further evaluation.

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  • (PMID = 27963232.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Duhoux F, Libouton J, Bahloula K, Ameye G, Poirel HA: Identification by FISH of 4 novel partner loci of PRDM16 in myeloid malignancies. J Clin Oncol; 2009 May 20;27(15_suppl):11037

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 11037 Background: PRDM16 is a gene located on 1p36.32 that encodes for a zinc finger transcription factor and contains an N-terminal PR domain.
  • These translocations result in the overexpression of a truncated version of the PRDM16 protein that lacks the PR domain.
  • METHODS: We studied 35 myeloid malignancies, 12 lymphoid malignancies and 3 undifferentiated acute leukemias with 1p36 abnormalities by fluorescent in situ hybridization (FISH) with a bacterial artificial chromosomes (BAC) contig containing 50 BAC probes on 1p36.

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  • (PMID = 27964015.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Jackman DM, Cioffredi L, Lindeman NI, Morse LK, Lucca J, Weckstein D, Huberman MS, Lynch TJ, Johnson BE, Janne PA: Phase II trial of erlotinib in chemotherapy-naive women with advanced pulmonary adenocarcinoma. J Clin Oncol; 2009 May 20;27(15_suppl):8065

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phase II trial of erlotinib in chemotherapy-naive women with advanced pulmonary adenocarcinoma.
  • : 8065 Background: This single-arm phase II study explored the role of clinical characteristics (female gender, adenocarcinoma histology, no tobacco within 1 year) in selecting pts for 1st-line therapy w/ erlotinib.
  • METHODS: Eligible pts were chemotherapy-naïve women, stage IIIB/ IV, PS 0-2, adenocarcinoma, and w/ available tissue for analysis of EGFR mutation status.
  • Pts received erlotinib 150 mg PO daily until disease progression or unacceptable toxicity.
  • Median age 68 (range 34-88); 59 PS 0, 24 PS 1, 1 PS 2; race: 79 white, 3 Asian, 2 black; 16 pts had BAC or predominant BAC features; smoking status: 35 never, 49 former.

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  • (PMID = 27962638.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Cetin K, Ettinger DS, Hei Y, O'Malley CD: Prognostic factors by histologic subtype in stage IV non-small cell lung cancer (NSCLC): A population-based survival analysis of data from the Surveillance, Epidemiology, and End Results (SEER) Program (1988-2003). J Clin Oncol; 2009 May 20;27(15_suppl):11053

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors by histologic subtype in stage IV non-small cell lung cancer (NSCLC): A population-based survival analysis of data from the Surveillance, Epidemiology, and End Results (SEER) Program (1988-2003).
  • : 11053 Background: Representing roughly 85% of all lung cancers, NSCLC is frequently diagnosed at an advanced stage and has a poor prognosis.
  • To better understand the prognostic importance of select patient and tumor characteristics in late-stage disease, we examined survival in patients diagnosed with stage IV NSCLC.
  • The distribution of cases according to time period of diagnosis and select patient and tumor characteristics was described for each histologic subtype (squamous; adenocarcinoma (bronchioloalveolar adenocarcinoma (BAC), non-BAC); large cell; and other/unknown).
  • RESULTS: Most recent period of diagnosis (1998-2003 versus 1988-1992) conferred a survival advantage across histologic subtypes, independent of gender, age, ethnicity/race, tumor grade, and uptake of surgery/radiation.
  • This was especially pronounced for those diagnosed with large cell tumors (adjusted hazard ratio (aHR): 0.76, 95% confidence interval (CI): 0.71-0.82).
  • Similarly, females survived longer than males across histologic groups, particularly for those with BAC tumors (aHR: 0.77, 95% CI: 0.66-0.89).
  • Increasing age was associated with reduced survival in all histologic subtypes except BAC, where prognosis was poorest in the youngest age group.
  • The influence of ethnicity/race also varied with histology: compared to Whites, American Indians/Alaskan Natives with squamous tumors and Blacks with large cell tumors had a poorer prognosis, whereas Asians/Pacific Islanders with either non-BAC or large cell tumors demonstrated superior survival.
  • Nonetheless, lung cancer remains a deadly disease, and the prognostic effect of demographic factors varies with histologic subtype.

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  • (PMID = 27963160.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Gaile DP, Shepherd L, Liu S, Darcy K, Brady M, Morrison C: iGenomicViewer, a Gynecologic Oncology Group software library for the creation of highly customizable, portable, interactive, and linked visualizations of high throughput genomic data. J Clin Oncol; 2009 May 20;27(15_suppl):e16544

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A set of R functions were created to extend the functionality of the sendplot R library.
  • The functions were applied to BAC aCGH data generated for several GOG studies.
  • 2) a set of interactive annotation tracks which display location of cancer, disease and DNA repair genes; and 3) a plot which displays -log10 p-values and/or aberration frequencies for the BAC assays depicted in the heatmap.
  • For the smallest regions of interest, the panel of plots contains a tiled heatmap which depicts the overlap and gaps in BAC coverage and their alignment with the gene locations represented in the adjacent annotation track.

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  • (PMID = 27960821.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Soto Parra HJ, Ippolito M, Tiseo M, Cosentino S, Ardizzoni A, Latteri F, Pumo V, Cordio S, Bordonaro R, Spadaro P: Usefulness of 18FDG-positron emission tomography (FDG-PET) for early prediction of erlotinib (Eb) treatment outcome in non-small cell lung cancer (NSCLC) patients: Results of a pilot study. J Clin Oncol; 2009 May 20;27(15_suppl):7568

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Usefulness of 18FDG-positron emission tomography (FDG-PET) for early prediction of erlotinib (Eb) treatment outcome in non-small cell lung cancer (NSCLC) patients: Results of a pilot study.
  • Glucose metabolic activity seems to closely reflect response to epidermal growth factor receptor (EGFR) TKI in vivo and in vitro (Su H et al, Clin Cancer Res 2006;12:5659-67).
  • RESULTS: From May 2007, 27 pts were enrolled and 23 were evaluable (4 not-evaluable: 2 BAC PET negative, 2 violations).
  • FDG-PET revealed a metabolic partial response (PR) in 8 pts; subsequent CT scan assessment evidenced 4 PR and 4 long lasting stable disease (SD), respectively.
  • Seven pts had metabolic progressive disease (PD) at PET scan and 8 had SD, all of them presented PD at CT scan.

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  • (PMID = 27963364.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczesna A, Juhasz E, Esteban Gonzalez E, Molinier O, Klingelschmitt G, Giaccone G, SATURN Investigators: SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC. J Clin Oncol; 2009 May 20;27(15_suppl):8001

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Patients with no evidence of disease progression after 4 cycles of CT were randomized to receive either E 150 mg/day or P until progression or unacceptable toxicity.
  • Baseline characteristics for E and P arms (%): male/female: 73/27 and 75/25; adenocarcinoma + BAC/squamous-cell/other: 47/38/15 and 44/43/13; stage IIIB/IV: 26/74 and 24/76; Caucasian/Asian/other: 84/14/2 and 83/15/2; ECOG PS 0/1: 31/69 and 32/68; current/former/never smoker: 55/28/18 and 56/27/17.
  • Disease control rate (complete response + partial response + stable disease >12 wks) was 40.8% with E versus 27.4% with P (p<.0001).
  • Erlotinib in the 1st-line maintenance setting is well tolerated, and significantly improves disease control and delays progression versus placebo across patient subgroups.

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  • (PMID = 27962767.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Vinolas N, Magem M, Garrido P, Artal A, De Castro J, Campelo RG, Isla D, Felip E, Amador M, Rosell R: Lung cancer in women: The Spanish female-specific database WORLD 07. J Clin Oncol; 2009 May 20;27(15_suppl):8084

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lung cancer in women: The Spanish female-specific database WORLD 07.
  • : 8084 Background: Lung cancer is the leading cause of cancer mortality among women in many countries.
  • METHODS: WORLD07 is a prospective, multicenter, epidemiologic female-specific lung cancer database developed by the Spanish Lung Cancer Group.
  • Data on demographics, previous cancer history, reproductive and hormonal status, diet, alcohol, tobacco, and occupational information are being collected just as histology, stage, treatment and survival.
  • RESULTS: From October 2007 to Nov 2008, 342 female newly diagnosed of lung cancer were collected in an e-database in 20 Spanish centers.
  • Familial history of cancer: 45.5% (lung cancer 29.7%).
  • Previous history of cancer 13.8% (breast 33.3%).
  • Current lung cancer histology (%): adenocarcinoma/BAC/squamous/large cell/NOS: 70.4/5.7/10.4/7.9/5.7.
  • CONCLUSIONS: According this series, 42% of Spanish lung cancer women are never smokers and 70.4% have adenocarcinoma.

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  • (PMID = 27962661.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Morrison C, Gaile D, Darcy K, Liu S, Shepherd L, Cohn D, McMeekin S, Nowak N, Maxwell L: A Gynecologic Oncology Group study of frequent copy number aberrations in African American versus Caucasian women with stage I versus stage IIIC/IV endometrioid endometrial cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e16501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A Gynecologic Oncology Group study of frequent copy number aberrations in African American versus Caucasian women with stage I versus stage IIIC/IV endometrioid endometrial cancer.
  • RPCI 19K BAC arrays were hybridized (GeneTAC HybStation) and scanned (Gene Pix 4200AL Laser Scanner).
  • Validation will be performed by fluorescence in situ hybridization using select BAC probes and endometrial cancer tissue microarrays (TMAs) with either 400 cases linked with clinical, treatment and outcome data or 180 AA versus 120 C women from GOG-136.
  • Distinct genomic losses and gains were observed that appear to segregate Caucasian women with stage I disease from African American women with stage I disease and African American or Caucasian women with stage IIIC/IV disease.
  • Validation studies are currently underway in two endometrial cancer TMAs.

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  • (PMID = 27960767.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Nakayama H, Kato Y, Tsuboi M, Okumura S, Daisaki H, Uehara H, Adachi S, Yoshimura M, Okada M: Value of FDG-PET/CT findings revised using an anthropomorphic body phantom for the evaluation of tumor malignancy grade in small-sized lung adenocarcinomas: A multicenter study. J Clin Oncol; 2009 May 20;27(15_suppl):7573

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Value of FDG-PET/CT findings revised using an anthropomorphic body phantom for the evaluation of tumor malignancy grade in small-sized lung adenocarcinomas: A multicenter study.
  • : 7573 Background: The malignant behavior of small lung adenocarinomas (AD), which have been detected with increasing frequency recently, has not yet been clearly evaluated, and an understanding of this biological characteristic is vital for selecting the appropriate therapeutic strategy.
  • We examined the malignancy grade of small lung ADs using FDG-PET/CT (PET), in addition to high-resolution CT (HRCT) and pathologic evaluation in a multicenter setting.
  • METHODS: A total of 204 patients with cT1N0M0 AD underwent PET and HRCT, followed by complete resection with lymph node dissection.
  • The associations between components of bronchioloalveolar carcinoma (BAC) on pathologic examination and maximum standardized uptake value (maxSUV) on PET, ground-glass opacity (GGO) ratio and tumor disappearance rate (TDR) on HRCT were examined, and these findings were analyzed in relation to pathologic features and surgical outcomes.
  • RESULTS: Examination of tumor aggressiveness based on the presence of lymphatic, vascular and pleural invasion, and of nodal metastasis, showed that maxSUV, BAC ratio, TDR, and GGO ratio, in the order, can reflect the malignancy grade.
  • MaxSUV and BAC ratio were also valuable prognostic predictors of the disease-free survival.
  • Although BAC ratio was significantly associated with maxSUV, GGO ratio and TDR (all p<0.0001), the degree of association with maxSUV (R2=0.2533) was weaker than that with GGO (R2=0.5843) ratio or TDR (R2=0.5123).
  • CONCLUSIONS: A higher maxSUV reflects an aggressive malignant behavior of cT1N0M0 ADs, independently of BAC component.
  • Assessment by PET in addition to HRCT is useful for selection of the appropriate treatment strategy for small lung AD.

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  • (PMID = 27963381.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Seki N, Eguchi K, Kaneko M, Ohmatsu H, Kakinuma R, Matsui E, Kusumoto M, Tsuchida T, Nishiyama H, Moriyama N: Stage-size relationship in long-term repeated CT screening for lung cancer: Anti-Lung Cancer Association project. J Clin Oncol; 2009 May 20;27(15_suppl):1540

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stage-size relationship in long-term repeated CT screening for lung cancer: Anti-Lung Cancer Association project.
  • : 1540 Background: We have investigated the individualized benefit of CT screening as Anti-Lung Cancer Association projects (presented at ASCO 2006-2008).
  • However, there has not been enough information about the relationship of lung cancer stage to tumor size in repeated CT screening.
  • Therefore, we evaluated the stage-size relationship of these asymptomatic lung cancer cases diagnosed by long-term repeated screening with low-dose helical CT.
  • Histology for the categories 15 mm or less was localized bronchioloalveolar carcinoma in 13 cases, adenocarcinoma with mixed subtype in 11 cases, invasive adenocarcinoma in five cases, other non-small cell carcinoma in 10 cases, and small cell carcinoma in one case.
  • CONCLUSIONS: These results provide direct evidence of a stage-size relationship in long-term repeated CT screening for lung cancer.
  • Furthermore, early detection of lung cancer of 15 mm or less in diameter leads to the detection of early-stage (N0M0) lung cancer in repeated CT screening.

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  • (PMID = 27964081.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Osoegawa A, Takeda Y, Kometani T, Ondo K, Fukuyama S, Hirai F, Nosaki K, Seto T, Oda S, Ichinose Y: LKB1 mutations in mucinous bronchioloalveolar carcinoma occurring in Peutz-Jeghers syndrome patients. J Clin Oncol; 2009 May 20;27(15_suppl):11047

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] LKB1 mutations in mucinous bronchioloalveolar carcinoma occurring in Peutz-Jeghers syndrome patients.
  • : 11047 Background: Mutations in the gene encoding Liver Kinase B1, LKB1, are common in patients with Peutz-Jeghers syndrome (PJS), which is characterized by mucocutaneous pigmentation, intestinal polyps and a high incidence of cancers at variable sites (colorectal, gynecological, breast, pancreas, and lung).
  • Although tumors occurring in PJS patients are known to contain mucin-rich conmponents, mucinous bronchioloalveolar carcinomas (mBACs) arising from the PJS background have only rarely been reported.
  • CONCLUSIONS: The relatively high frequency of LKB1 mutation in mBAC patients may suggest its implication in lung carcinogenesis, at least in mBAC, and its potential as a therapeutic target.

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  • (PMID = 27963987.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Subramanian J, Pillot G, Narra V, Govindan R: Response to bortezomib (velcade) in a case of advanced bronchiolo-alveolar carcinoma (BAC). A case report. Lung Cancer; 2006 Feb;51(2):257-9
Hazardous Substances Data Bank. BORTEZOMIB .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Response to bortezomib (velcade) in a case of advanced bronchiolo-alveolar carcinoma (BAC). A case report.
  • A 65-year-old male with 40-pack year smoking history presented with exertional dyspnea and was subsequently diagnosed with bronchiolo-alveolar carcinoma (BAC).
  • He did not respond to first line therapy with geftinib, but he achieved disease stabilization with gemcitabine and carboplatin for 4 months before developing symptomatic worsening requiring oxygen supplementation.
  • Based on observations like this and those seen in phase I studies with bortezomib, this agent is being studied now in patients with bronchio-alevolar cancer.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Antineoplastic Agents / therapeutic use. Boronic Acids / therapeutic use. Lung Neoplasms / drug therapy. Pyrazines / therapeutic use

  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • MedlinePlus Health Information. consumer health - Lung Cancer.
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  • [CommentIn] Lung Cancer. 2007 Aug;57(2):249-50 [17599646.001]
  • (PMID = 16387387.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Boronic Acids; 0 / Pyrazines; 69G8BD63PP / Bortezomib
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31. Jeong Y, Epstein DJ: Modification and production of BAC transgenes. Curr Protoc Mol Biol; 2005 Aug;Chapter 23:Unit 23.11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modification and production of BAC transgenes.
  • Bacterial artificial chromosomes (BACs) are the vectors of choice for the construction of genomic DNA libraries and, as such, have proven instrumental in the generation of large-scale physical maps; positional cloning projects; and the sequencing of human, mouse, and a plethora of other genomes.
  • A number of methods have recently been developed to modify BAC DNA (e.g., insertion, deletion, substitution), making BACs even more useful for functional genomic research.
  • This unit describes two protocols for BAC modification in E. coli, one that allows for specific changes at a given DNA sequence and another that is more suited for rapid and nonspecific integration of foreign DNA (such as a reporter cassette) into a BAC insert.
  • In addition, a simple and reliable method for preparing BAC DNA for pronuclear microinjection is also provided.

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  • (PMID = 18265362.001).
  • [ISSN] 1934-3647
  • [Journal-full-title] Current protocols in molecular biology
  • [ISO-abbreviation] Curr Protoc Mol Biol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Transposable Elements
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32. Coe BP, Lockwood WW, Chari R, Lam WL: Comparative genomic hybridization on BAC arrays. Methods Mol Biol; 2009;556:7-19
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative genomic hybridization on BAC arrays.
  • Alterations in genomic DNA are a key feature of many constitutional disorders and cancer.
  • The discovery of the underlying regions of gene dosage has thus been essential in dissecting complex disease phenotypes and identifying targets for therapeutic intervention and diagnostic testing.
  • The development of array comparative genomic hybridization (aCGH) using bacterial artificial chromosomes (BACs) as hybridization targets has facilitated the discovery and fine mapping of novel genomic alterations allowing rapid identification of target genes.
  • In BAC aCGH, DNA samples are first labeled with fluorescent dyes through a random priming reaction with 100-400 ng of genomic DNA.
  • This probe is then co-hybridized to an array consisting of BAC clones, either tiling the genome (approximately 50 kbp resolution) or spaced at intervals (e.g., 1 Mbp resolution).
  • The DNA samples to be analyzed may be derived from either fresh, frozen, or formalin-fixed paraffin-embedded material, and sample requirements are currently significantly lower than those for oligonucleotide platforms due to the high probe-binding capacity of BAC clone targets (approximately 150 kbp) compared to oligonucleotides (25-80 bp).
  • In this chapter, we describe in detail the technical procedure required to perform copy number analysis of genomes with BAC aCGH.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Comparative Genomic Hybridization. Oligonucleotide Array Sequence Analysis

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  • (PMID = 19488868.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE15965
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. Prabhu S, Smitha RS, Punnya VA: Merkel cell carcinoma of the alveolar mucosa in a young adult: a rare case report. Br J Oral Maxillofac Surg; 2010 Jan;48(1):48-50
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Merkel cell carcinoma of the alveolar mucosa in a young adult: a rare case report.
  • Merkel cell carcinoma (MCC) is an extremely rare and aggressive primary neuroendocrine neoplasm of the skin with a poor prognosis.
  • We report a rare case of MCC that arose in the alveolar mucosa of a young adult.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adult. Alveolar Process / pathology. Chromogranins / analysis. Follow-Up Studies. Humans. Keratin-3 / analysis. Lymphatic Metastasis / pathology. Male. Mouth Floor / pathology. Oral Ulcer / pathology. Radiography, Panoramic

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  • [Copyright] Copyright 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19167791.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Chromogranins; 0 / KRT3 protein, human; 0 / Keratin-3
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34. Lysak MA, Mandáková T, Lacombe E: Reciprocal and multi-species chromosome BAC painting in crucifers (Brassicaceae). Cytogenet Genome Res; 2010 Jul;129(1-3):184-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reciprocal and multi-species chromosome BAC painting in crucifers (Brassicaceae).
  • In crucifer cytogenomics, BAC contigs of Arabidopsis thaliana have been used as probes for comparative chromosome painting among species.
  • Here we successfully tested chromosome-specific BAC contigs of A. thaliana (n = 5) and A. halleri (n = 8) as probes for reciprocal BAC painting.
  • Furthermore, BAC contigs of both Arabidopsis species were applied as multi-species painting probes to a third crucifer species, Noccaea caerulescens (n = 7), revealing their shared chromosome homeology.
  • [MeSH-major] Brassicaceae / genetics. Chromosome Painting / methods. Chromosomes, Artificial, Bacterial / genetics. Chromosomes, Plant / genetics

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20501976.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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35. Kong LY, Zhang XJ, Wang ZS: [Removal of organic pollutants by adsorption cooperated with biodegradation in BAC]. Huan Jing Ke Xue; 2007 Apr;28(4):777-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Removal of organic pollutants by adsorption cooperated with biodegradation in BAC].
  • The determination measure for distribution of NOM removal by two mechanisms in BAC was established.
  • In this method, the change in DOC and BDOC of inflow and effluent was used to evaluate the distribution and to determinate the effect of the different ozone doses on the adsorption and biodegradation in BAC.
  • The ozonation increased the concentration of BDOC in 0.12 - 0.54 mg/L with ozone dose of 2 - 8 mg/L and BAC filtration decreased concentration of BDOC to 0.23 - 0.31 mg/L.

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  • (PMID = 17639936.001).
  • [ISSN] 0250-3301
  • [Journal-full-title] Huan jing ke xue= Huanjing kexue
  • [ISO-abbreviation] Huan Jing Ke Xue
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Water Pollutants, Chemical; 16291-96-6 / Charcoal
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36. Jenkins G, Hasterok R: BAC 'landing' on chromosomes of Brachypodium distachyon for comparative genome alignment. Nat Protoc; 2007;2(1):88-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BAC 'landing' on chromosomes of Brachypodium distachyon for comparative genome alignment.
  • Fluorescence in situ hybridization (FISH) using bacterial artificial chromosomes (BACs) with large genomic DNA inserts as probes (BAC 'landing') is a powerful means by which eukaryotic genomes can be physically mapped and compared.
  • Here we report a BAC landing protocol that has been developed specifically for the weedy grass species Brachypodium distachyon, which has been adopted recently by the scientific community as an alternative model for the temperate cereals and grasses.
  • The protocol describes the preparation of somatic and meiotic chromosome substrates for FISH, the labeling of BACs, a chromosome mapping strategy, empirical conditions for optimal in situ hybridization and stringency washing, the detection of probes and the capturing and processing of images.
  • The expected outcome of the protocol is the specific assignment of BACs containing single-copy inserts to one of the five linkage groups of the genome of this species.
  • [MeSH-major] Chromosome Mapping / methods. Chromosomes, Artificial, Bacterial / genetics. Genetic Techniques. Genome, Plant / genetics. Poaceae / genetics

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  • (PMID = 17401342.001).
  • [ISSN] 1750-2799
  • [Journal-full-title] Nature protocols
  • [ISO-abbreviation] Nat Protoc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
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37. Madishetty K, Condamine P, Svensson JT, Rodriguez E, Close TJ: An improved method to identify BAC clones using pooled overgos. Nucleic Acids Res; 2007;35(1):e5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An improved method to identify BAC clones using pooled overgos.
  • Hybridization using overgo probes is an established approach for screening arrayed bacterial artificial chromosome (BAC) libraries.
  • The resulting cost savings and reduced human exposure to radiation make the use of highly pooled overgo probes a more attractive approach for screening of BAC libraries from organisms with large genomes.
  • [MeSH-major] Chromosomes, Artificial, Bacterial. Genomic Library. Oligonucleotide Probes

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  • (PMID = 17151072.001).
  • [ISSN] 1362-4962
  • [Journal-full-title] Nucleic acids research
  • [ISO-abbreviation] Nucleic Acids Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oligonucleotide Probes; 0 / Radioisotopes
  • [Other-IDs] NLM/ PMC1761434
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38. Ren ZJ, Ma J, Cao XC: [Effect of PPC preoxidation on BAC process for removing organic matters]. Huan Jing Ke Xue; 2006 Oct;27(10):2045-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Effect of PPC preoxidation on BAC process for removing organic matters].
  • The effect of PPC preoxidation on BAC process for organic pollutants removal was conducted by measuring the distribution of relative molecular mass, the concentrations of organic and inorganic matters on BAC.
  • On the other hand, organic matters of relative molecular mass less than 3 x 10(3) is increased with PPC preoxidation, which improves the biological activity of BAC process.
  • The concentrations of organic and inorganic matters on BAC with PPC preoxidation are reduced 5.0 mg x g(-1) and 4.16 mg x g(-1) respectively than that on BAC alone, which reduces the block of hole on GAC and increases the life time of BAC process.

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  • (PMID = 17256607.001).
  • [ISSN] 0250-3301
  • [Journal-full-title] Huan jing ke xue= Huanjing kexue
  • [ISO-abbreviation] Huan Jing Ke Xue
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Water Pollutants, Chemical; 00OT1QX5U4 / Potassium Permanganate; 16291-96-6 / Charcoal; 7440-44-0 / Carbon
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39. Parchem RJ, Poulin F, Stuart AB, Amemiya CT, Patel NH: BAC library for the amphipod crustacean, Parhyale hawaiensis. Genomics; 2010 May;95(5):261-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BAC library for the amphipod crustacean, Parhyale hawaiensis.
  • Bacterial artificial chromosomes (BACs) are capable of propagating large fragments of DNA and have become an invaluable tool for studying genome biology.
  • To fill a phylogenetic gap in available genomic sequence and to complement ongoing molecular and genetic studies, we have generated a BAC library for the marine amphipod crustacean, Parhyale hawaiensis.
  • We have screened the Parhyale BAC library for developmentally relevant genes and characterized the genomic organization of four genes: a hedgehog ortholog, and three Pax3/7 paralogs.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Crustacea / genetics. Genomic Library. Transcription Factors / genetics

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20298775.001).
  • [ISSN] 1089-8646
  • [Journal-full-title] Genomics
  • [ISO-abbreviation] Genomics
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Transcription Factors
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40. Yang XW, Gong S: An overview on the generation of BAC transgenic mice for neuroscience research. Curr Protoc Neurosci; 2005 May;Chapter 5:Unit 5.20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An overview on the generation of BAC transgenic mice for neuroscience research.
  • This unit provides a comprehensive overview on the generation of transgenic mice using bacterial artificial chromosomes (BACs), and the application of BAC transgenic mice in neuroscience research.
  • In the first section, advantages of the BAC transgenic approach compared to the conventional transgenic approach are summarized.
  • In the second section, important considerations in designing BAC transgenic constructs are outlined.
  • Four commonly used BAC transgenic construct designs are also outlined.
  • Concepts of modifying BACs by homologous recombination in E. coli to introduce a variety of mutations into BACs, and important steps to characterize a modified BAC prior to the generation of transgenic mice are also presented.
  • In the final section, some of the important applications of BAC transgenic mice in neuroscience research, including studying gene expression, gene function, mapping neuronal circuitry, and modeling human diseases, are described.

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  • (PMID = 18428622.001).
  • [ISSN] 1934-8576
  • [Journal-full-title] Current protocols in neuroscience
  • [ISO-abbreviation] Curr Protoc Neurosci
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Escherichia coli Proteins
  • [Number-of-references] 31
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41. Gorman DM, Huber JC Jr, Carozza SE: Evaluation of the Texas 0.08 BAC law. Alcohol Alcohol; 2006 Mar-Apr;41(2):193-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the Texas 0.08 BAC law.
  • AIMS: The purpose of the present study was to assess the effects on alcohol-involved traffic crashes and fatalities of the 0.08 blood alcohol concentration (BAC) per se law introduced in the state of Texas in 1999.
  • CONCLUSIONS: While there is a growing body of evidence that indicates that 0.08 BAC laws can be effective in reducing alcohol-involved traffic accidents and fatalities, the present study shows that this was not the case in Texas.
  • Future research should move beyond the simple question of whether or not 0.08 BAC laws 'work' and instead explore in more detail the conditions, such as publicity and enforcement, under which the law does or does not contribute to a decline in alcohol-involved accidents and fatalities.

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  • (PMID = 16364969.001).
  • [ISSN] 0735-0414
  • [Journal-full-title] Alcohol and alcoholism (Oxford, Oxfordshire)
  • [ISO-abbreviation] Alcohol Alcohol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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42. Roohi J, Cammer M, Montagna C, Hatchwell E: An improved method for generating BAC DNA suitable for FISH. Cytogenet Genome Res; 2008;121(1):7-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An improved method for generating BAC DNA suitable for FISH.
  • These probes are often generated from DNA sequences cloned within bacterial artificial chromosomes (BACs).
  • Growing these BACs in adequate amounts for FISH can be demanding.
  • We describe FISH performed with bacteriophage Phi29 DNA polymerase amplified BAC DNA.
  • The FISH results obtained were comparable with those obtained from standard BAC DNA.
  • We believe this method of BAC DNA generation is useful for the entire FISH community as it improves considerably on prior methods.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. DNA, Recombinant / biosynthesis. DNA, Recombinant / genetics. In Situ Hybridization, Fluorescence / methods

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  • [Copyright] (c) 2008 S. Karger AG, Basel.
  • (PMID = 18544919.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA, Recombinant; EC 2.7.7.7 / DNA-Directed DNA Polymerase; EC 3.6.1.- / GTP Phosphohydrolases; EC 3.6.1.- / SEPT9 protein, human; EC 3.6.1.- / Septins
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43. Zhong M, De Angelo P, Osborne L, Keane-Tarchichi M, Goldfischer M, Edelmann L, Yang Y, Linehan WM, Merino MJ, Aisner S, Hameed M: Dual-color, break-apart FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of Xp11 translocation renal cell carcinoma and alveolar soft part sarcoma. Am J Surg Pathol; 2010 Jun;34(6):757-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dual-color, break-apart FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of Xp11 translocation renal cell carcinoma and alveolar soft part sarcoma.
  • Both Xp11.2 translocation renal cell carcinoma (RCC) and alveolar soft part sarcoma (ASPS) are characterized by various translocations disrupting chromosome Xp11.2, which result in gene fusions involving the TFE3 transcription factor gene.
  • This assay was validated using 4 cases of Xp11.2 RCC [proven by karyotype and/or reverse-transcriptase polymerase chain reaction (RT-PCR)], 2 cases of ASPS (proven by karyotype or RT-PCR), the UOK109 cell line carrying the inv(X) (p11;q12), and several negative controls (both neoplastic and non-neoplastic).
  • [MeSH-major] Carcinoma, Renal Cell / genetics. Chromosomes, Human, Pair 11 / genetics. Chromosomes, Human, X / genetics. In Situ Hybridization, Fluorescence / methods. Kidney Neoplasms / genetics. Sarcoma, Alveolar Soft Part / genetics

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  • (PMID = 20421778.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / TFE3 protein, human
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44. Sazanov AA, Malewski T, Kamiński S, Zwierzchowski L: Characterization of the CHORI-240 BAC clones containing the bovine CSN1S1, CSN2, STATH, CSN1S2 and CSN3 genes. J Appl Genet; 2006;47(3):243-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of the CHORI-240 BAC clones containing the bovine CSN1S1, CSN2, STATH, CSN1S2 and CSN3 genes.
  • Nineteen BAC clones were identified by hybridization of the bovine genomic BAC library CHORI-240 with mixed CSN1S1- and CSN3-specific probes.
  • These data showed that the BAC contig was established for the whole casein cluster, including all known five genes.
  • [MeSH-major] Caseins / genetics. Cattle / genetics. Chromosomes, Artificial, Bacterial

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  • (PMID = 16877803.001).
  • [ISSN] 1234-1983
  • [Journal-full-title] Journal of applied genetics
  • [ISO-abbreviation] J. Appl. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Caseins; 0 / DNA Primers
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45. Warming S, Costantino N, Court DL, Jenkins NA, Copeland NG: Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res; 2005;33(4):e36
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simple and highly efficient BAC recombineering using galK selection.
  • Here, we describe the construction of three new recombineering strains (SW102, SW105 and SW106) that allow bacterial artificial chromosomes (BACs) to be modified using galK positive/negative selection.
  • We also show how galK selection can be used to rapidly introduce point mutations, deletions and loxP sites into BAC DNA and thus facilitate functional studies of SNP and/or disease-causing point mutations, the identification of long-range regulatory elements and the construction of conditional targeting vectors.
  • [MeSH-major] Chromosomes, Artificial, Bacterial. Escherichia coli / genetics. Escherichia coli Proteins / genetics. Galactokinase / genetics. Genetic Engineering. Recombination, Genetic

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  • [Cites] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5978-83 [10811905.001]
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  • (PMID = 15731329.001).
  • [ISSN] 1362-4962
  • [Journal-full-title] Nucleic acids research
  • [ISO-abbreviation] Nucleic Acids Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Escherichia coli Proteins; EC 2.7.1.6 / Galactokinase; X2RN3Q8DNE / Galactose
  • [Other-IDs] NLM/ PMC549575
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46. Kong LY, Zhang XJ, Wang ZS: [Determination for optimal ozone dose in O3-BAC]. Huan Jing Ke Xue; 2006 Jul;27(7):1345-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Determination for optimal ozone dose in O3-BAC].
  • In the test, the AOC of effluent from BAC is lower than 50 microg/L (acetate-C).

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  • (PMID = 16881306.001).
  • [ISSN] 0250-3301
  • [Journal-full-title] Huan jing ke xue= Huanjing kexue
  • [ISO-abbreviation] Huan Jing Ke Xue
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Water Pollutants; 16291-96-6 / Charcoal; 66H7ZZK23N / Ozone
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47. Park MH, Lee HJ, Bok J, Kim CH, Hong ST, Park C, Kimm K, Oh B, Lee JY: Korean BAC library construction and characterization of HLA-DRA, HLA-DRB3. J Biochem Mol Biol; 2006 Jul 31;39(4):418-25

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Korean BAC library construction and characterization of HLA-DRA, HLA-DRB3.
  • A human bacterial artificial chromosome (BAC) library was constructed with high molecular weight DNA extracted from the blood of a male Korean.
  • This Korean BAC library contains 100,224 clones of insert size ranging from 70 to 150 kb, with an average size of 86 kb, corresponding to a 2.9-fold redundancy of the genome.
  • The average insert size was determined from 288 randomly selected BAC clones that were well distributed among all the chromosomes.
  • We developed a pooling system and three-step PCR screen for the Korean BAC library to isolate desired BAC clones, and we confirmed its utility using primer pairs designed for one of the clones.
  • The Korean BAC library and screening pools will allow PCR-based screening of the Korean genome for any gene of interest.
  • The haplotype found in this library will provide useful information in future human disease studies.
  • [MeSH-minor] Asian Continental Ancestry Group. Chromosomes, Artificial, Bacterial. HLA-DR alpha-Chains. HLA-DRB3 Chains. Haplotypes. Humans. Male

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  • (PMID = 16889686.001).
  • [ISSN] 1225-8687
  • [Journal-full-title] Journal of biochemistry and molecular biology
  • [ISO-abbreviation] J. Biochem. Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / HLA-DR Antigens; 0 / HLA-DR alpha-Chains; 0 / HLA-DRB3 Chains
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48. Xu Q, Anderson SA: Mapping lineage using BAC-Cre reporter lines. Curr Protoc Neurosci; 2010 Jan;Chapter 1:Unit 1.19

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mapping lineage using BAC-Cre reporter lines.
  • An effective and versatile approach for tracing lineage of progenitors into adult cell types is to target the promoter of an interested gene with Cre (a phage DNA recombinase) to achieve simultaneous activation during neurogenesis.
  • The bacterial artificial chromosome (BAC) is an efficient Cre carrier.
  • Not only the targeted gene remains diploidy in BAC-Cre transgenic mice, but also the large portions of the gene's regulatory elements to be incorporated in the BAC allow Cre to sufficiently and reliably reproduce the endogenous gene expression pattern.
  • When the BAC-Cre mouse is crossed to a Cre reporter mouse, even Cre is transiently expressed.
  • Experimental designs and procedures for RecA-based BAC DNA modification and preparation for pronuclear injection are highlighted.
  • Suggestions for the use of BAC-Cre transgenic mice in fate-mapping analyses are also provided.

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  • (PMID = 20066654.001).
  • [ISSN] 1934-8576
  • [Journal-full-title] Current protocols in neuroscience
  • [ISO-abbreviation] Curr Protoc Neurosci
  • [Language] ENG
  • [Grant] United States / NIMH NIH HHS / MH / R01 MH066912
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial; 147336-22-9 / Green Fluorescent Proteins; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases; EC 2.7.7.- / Rec A Recombinases
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49. Jiang S, Zhong X, Zhai C, Chen L, Ma L, Jin M, Chen H: Constructing recombinant herpesvirus BAC vectors with mating-assisted genetically integrated clone method. Biotechnol Lett; 2010 Jul;32(7):903-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Constructing recombinant herpesvirus BAC vectors with mating-assisted genetically integrated clone method.
  • Here we introduced a cloning strategy that facilitates construction of recombinant PRV-BAC vectors based on mating-assisted genetically integrated clone (MAGIC).
  • The target gene was cloned into a small conditionally replicating donor plasmid, followed by shuffling to a recipient PRV-BAC plasmid in vivo of Escherichia coli through MAGIC.
  • [MeSH-major] Chromosomes, Artificial, Bacterial. Gene Targeting / methods. Genetic Engineering / methods. Genetic Vectors. Herpesvirus 1, Suid / genetics. Recombination, Genetic

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  • (PMID = 20349331.001).
  • [ISSN] 1573-6776
  • [Journal-full-title] Biotechnology letters
  • [ISO-abbreviation] Biotechnol. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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50. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF: Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet; 2005 Jun;37(6):645-51
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3.
  • We developed a method for high-resolution analysis of the methylation status of CpG islands genome-wide, using arrays of BAC clones and the methylation-sensitive restriction enzyme NotI.
  • [MeSH-major] Carrier Proteins / metabolism. Chromosomes, Artificial, Bacterial. CpG Islands. DNA Methylation

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  • (PMID = 15895082.001).
  • [ISSN] 1061-4036
  • [Journal-full-title] Nature genetics
  • [ISO-abbreviation] Nat. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Nerve Tissue Proteins; 0 / SHANK3 protein, human; EC 3.1.21.- / endodeoxyribonuclease BSSHII; EC 3.1.21.4 / Deoxyribonucleases, Type II Site-Specific; EC 3.1.21.4 / GCGGCCGC-specific type II deoxyribonucleases
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51. Shoguchi E, Kawashima T, Satou Y, Hamaguchi M, Sin-I T, Kohara Y, Putnam N, Rokhsar DS, Satoh N: Chromosomal mapping of 170 BAC clones in the ascidian Ciona intestinalis. Genome Res; 2006 Feb;16(2):297-303
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chromosomal mapping of 170 BAC clones in the ascidian Ciona intestinalis.
  • Here, we report the molecular cytogenetic characterization of all 14 pairs of C. intestinalis chromosomes, as well as initial large-scale mapping of genomic sequences onto chromosomes by fluorescent in situ hybridization (FISH).
  • Two-color FISH using 170 bacterial artificial chromosome (BAC) clones and construction of joined scaffolds using paired BAC end sequences allowed for mapping of up to 65% of the deduced 117-Mb nonrepetitive sequence onto chromosomes.
  • [MeSH-minor] Animals. Chromosomes, Artificial, Bacterial / genetics. Gene Expression Regulation / genetics. In Situ Hybridization, Fluorescence / methods

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  • (PMID = 16354750.001).
  • [ISSN] 1088-9051
  • [Journal-full-title] Genome research
  • [ISO-abbreviation] Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1361726
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52. Zhang ZH, Shao L: Study on control of micro-pollutants by BAC filtration. Water Sci Technol; 2008;58(3):677-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Study on control of micro-pollutants by BAC filtration.
  • The objective of this research was to evaluate removal efficiency of micro-pollutants in a BAC filter that followed ozonation for long term operation.
  • The experimental results showed that after continuous operation for one year BAC filter still maintained a removal of 15 approximately 20% for COD(Mn) and 20 approximately 30% of removal for UV(254).
  • Correlative analysis based on lots of data found that empty bed contact time (EBCT) instead of flow rate could obviously impact on removal effect of micro-pollutants in BAC filter.
  • And the optimal relationship between EBCT and removal effect of micro-pollutants for BAC filter was logarithm.
  • On the other hand, long term running of BAC filter proved that there was a good removal of chloroform formation potential, but the removal of brominated trihalomethane formation potential decline with further bromization, even there appeared to be formation of bromoform in BAC filter.

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  • [Copyright] (c) IWA Publishing 2008.
  • (PMID = 18725738.001).
  • [ISSN] 0273-1223
  • [Journal-full-title] Water science and technology : a journal of the International Association on Water Pollution Research
  • [ISO-abbreviation] Water Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Trihalomethanes; 0 / Water Pollutants, Chemical; 16291-96-6 / Charcoal; 66H7ZZK23N / Ozone
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53. Schemerhorn BJ, Crane YM, Morton PK, Aggarwal R, Benatti T: Localization and characterization of 170 BAC-derived clones and mapping of 94 microsatellites in the Hessian fly. J Hered; 2009 Nov-Dec;100(6):790-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Localization and characterization of 170 BAC-derived clones and mapping of 94 microsatellites in the Hessian fly.
  • Ninety-four microsatellites from enriched genomic libraries of Hessian fly (Hf, Mayetiola destructor [Say]) were localized to 170 cognate clones in an Hf bacterial artificial chromosome (BAC) library.
  • These microsatellite-positive BAC clones were physically mapped to polytene chromosomes by fluorescent in situ hybridization.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Diptera / genetics. Gene Library. Genetic Variation. Genetics, Population. Microsatellite Repeats / genetics

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  • (PMID = 19592640.001).
  • [ISSN] 1465-7333
  • [Journal-full-title] The Journal of heredity
  • [ISO-abbreviation] J. Hered.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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54. Neill NJ, Torchia BS, Bejjani BA, Shaffer LG, Ballif BC: Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH. Mol Cytogenet; 2010;3:11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH.
  • It has been presumed that whole-genome oligonucleotide (oligo) arrays identify more clinically significant copy-number abnormalities than whole-genome bacterial artificial chromosome (BAC) arrays, yet this has not been systematically studied in a clinical diagnostic setting.
  • RESULTS: To determine the difference in detection rate between similarly designed BAC and oligo arrays, we developed whole-genome BAC and oligonucleotide microarrays and validated them in a side-by-side comparison of 466 consecutive clinical specimens submitted to our laboratory for aCGH.
  • Of the 466 cases studied, 67 (14.3%) had a copy-number imbalance of potential clinical significance detectable by the whole-genome BAC array, and 73 (15.6%) had a copy-number imbalance of potential clinical significance detectable by the whole-genome oligo array.
  • However, because both platforms identified copy number variants of unclear clinical significance, we designed a systematic method for the interpretation of copy number alterations and tested an additional 3,443 cases by BAC array and 3,096 cases by oligo array.
  • Of those cases tested on the BAC array, 17.6% were found to have a copy-number abnormality of potential clinical significance, whereas the detection rate increased to 22.5% for the cases tested by oligo array.
  • CONCLUSIONS: Although BAC arrays have faster turnaround times, the increased detection rate of oligo arrays makes them attractive for clinical cytogenetic testing.

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  • (PMID = 20587050.001).
  • [ISSN] 1755-8166
  • [Journal-full-title] Molecular cytogenetics
  • [ISO-abbreviation] Mol Cytogenet
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2909945
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55. Feederle R, Bartlett EJ, Delecluse HJ: Epstein-Barr virus genetics: talking about the BAC generation. Herpesviridae; 2010;1(1):6
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  • [Title] Epstein-Barr virus genetics: talking about the BAC generation.
  • More recently, HV genomes cloned onto a bacterial artificial chromosome (BAC) have become available.
  • HV BACs can be easily modified in E.coli and reintroduced in eukaryotic cells to produce infectious viruses.
  • Mutants derived from HV BACs have been used both to understand the functions of all types of genetic elements present on the virus genome, but also to generate mutants with potentially medically relevant properties such as preventative vaccines.
  • Here we retrace the development of the BAC technology applied to the Epstein-Barr virus (EBV) and review the strategies available for the construction of mutants.
  • We expand on the appropriate controls required for proper use of the EBV BACs, and on the technical hurdles researchers face in working with these recombinants.
  • Finally, we catalog the EBV BAC mutants that are currently available and illustrate their contributions to the field using a few representative examples.

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  • (PMID = 21429237.001).
  • [ISSN] 2042-4280
  • [Journal-full-title] Herpesviridae
  • [ISO-abbreviation] Herpesviridae
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3063228
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56. Wagenaar AC, Maldonado-Molina MM, Ma L, Tobler AL, Komro KA: Effects of legal BAC limits on fatal crash involvement: analyses of 28 states from 1976 through 2002. J Safety Res; 2007;38(5):493-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of legal BAC limits on fatal crash involvement: analyses of 28 states from 1976 through 2002.
  • We examined the effects of changes in legal BAC limit in 28 U.S. states from January, 1976 to December, 2002.
  • Four outcome measures of alcohol-related crash involvement were examined: single-vehicle nighttime, BAC=0.01-0.07, BAC=0.08-0.14, and BAC>/=0.15.
  • Missing BAC test result data were handled by using multiple imputations.
  • Inverse variance weighting methods were used to pool results across states for the most precise underlying estimate of effect of legal BAC limits.
  • Changes in legal BAC limits significantly affected alcohol-related fatal crash involvement for both the SVN and BAC test result measures, and the laws affected drivers at all drinking levels.
  • IMPACT ON INDUSTRY: Given the significant effects of lower legal BAC limits on fatal crash involvement, businesses should support implementation of laws that further reduce the legal BAC limit for all drivers.
  • Furthermore, all companies should set higher standards for employees, such as a zero allowable BAC limit for driving during work time.

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  • (PMID = 18023634.001).
  • [ISSN] 0022-4375
  • [Journal-full-title] Journal of safety research
  • [ISO-abbreviation] J Safety Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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57. Moraes AP, Mirkov TE, Guerra M: Mapping the chromosomes of Poncirus trifoliata Raf. by BAC-FISH. Cytogenet Genome Res; 2008;121(3-4):277-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mapping the chromosomes of Poncirus trifoliata Raf. by BAC-FISH.
  • In order to obtain a better chromosome characterization of one species from this group, CMA/DAPI double staining followed by in situ hybridization using 45S rDNA and 24 BACs (BAC-FISH) were used on Poncirus trifoliata.
  • The BACs used were obtained from a genomic library of this species and were selected by membrane hybridization using genomic DNA.
  • The P. trifoliata karyotype is composed of two chromosome pairs with one terminal and one proximal CMA(+) band (B type chromosomes), four chromosome pairs with a single CMA(+) band (D type) and three chromosome pairs without bands (F type).
  • In situ hybridization with 13 of the BACs gave single copy signals on seven chromosome pairs.
  • At least one BAC was mapped on each arm of the two B chromosome pairs.
  • Among the four D chromosome pairs, two were identified by BACs mapped on the long arms, one has a 45S rDNA site and the other had no signal.
  • Six BACs allowed identification of the three F chromosome pairs, with one pair hybridizing with four BACs from the Ctv resistance gene region.
  • In summary, all nine chromosome pairs could be differentiated, seven of them by BAC-FISH, while the other two chromosomes could be recognized by the CMA(+) band pattern and 45S rDNA sites.
  • This first BAC-FISH map gives a general framework for comparative genome structure and evolutionary studies in Citrus and Poncirus, allowing the integration of genetic and physical maps when these BACs are included.
  • [MeSH-major] Chromosome Mapping. Chromosomes, Artificial, Bacterial. Chromosomes, Plant. In Situ Hybridization, Fluorescence / methods. Poncirus / genetics

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18758171.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA, Ribosomal
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58. Chianetta JM, Lefebvre M, LeBlanc R, Grignon S: Comparative psychometric properties of the BACS and RBANS in patients with schizophrenia and schizoaffective disorder. Schizophr Res; 2008 Oct;105(1-3):86-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative psychometric properties of the BACS and RBANS in patients with schizophrenia and schizoaffective disorder.
  • The objectives of the present study were to compare the psychometric properties of two such batteries, the BACS (Brief Assessment of Cognition in Schizophrenia) and the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status).
  • METHODS: The French version of the BACS and the RBANS was administered to 36 patients with schizophrenia and schizoaffective disorder, and 14 healthy controls.
  • Internal consistency was satisfying (global scale reliability alphas of 0.90 for the BACS, and 0.87 for the RBANS), although some sub-scores from the RBANS decreased the overall consistency of the instrument.
  • BACS and RBANS composite scores were highly correlated to verbal, non-verbal and total WAIS-III scores (BACS: r=0.727, 0.865 and 0.857, respectively; RBANS: r=0.843, 0.747 and 0.875, respectively).
  • Patients underperformed controls by a magnitude of 1.81 SD (BACS), and 0.78 SD (RBANS), after adjusting for education.
  • CONCLUSION: The psychometric properties and ease of use of the BACS and the RBANS were overall satisfying.
  • The BACS demonstrated better internal consistency and test-retest reliability than the RBANS and was nominally more sensitive to diagnosis.
  • [MeSH-major] Cognition Disorders / diagnosis. Neuropsychological Tests / statistics & numerical data. Psychotic Disorders / diagnosis. Schizophrenia / diagnosis. Schizophrenic Psychology
  • [MeSH-minor] Adult. Diagnostic and Statistical Manual of Mental Disorders. Female. Humans. Male. Memory Disorders / diagnosis. Memory Disorders / psychology. Practice (Psychology). Psychiatric Status Rating Scales. Psychometrics. Reproducibility of Results. Sensitivity and Specificity. Wechsler Scales

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  • (PMID = 18790606.001).
  • [ISSN] 0920-9964
  • [Journal-full-title] Schizophrenia research
  • [ISO-abbreviation] Schizophr. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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59. Zhao Y, Petherbridge L, Smith LP, Baigent S, Nair V: Self-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity. Virol J; 2008;5:19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Self-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity.
  • Cloning of full length genomes of herpesviruses as bacterial artificial chromosomes (BAC) has greatly facilitated the manipulation of the genomes of several herpesviruses to identify the pathogenic determinants.
  • We have previously reported the construction of the BAC clone (pRB-1B5) of the highly oncogenic Marek's disease virus (MDV) strain RB-1B, which has proven to be a valuable resource for elucidating several oncogenic determinants.
  • Despite the retention of the BAC replicon within the genome, the reconstituted virus was able to induce tumours in susceptible chickens.
  • Nevertheless, it was unclear whether the presence of the BAC influenced the full oncogenic potential of the reconstituted virus.
  • To maximize the closeness of BAC-derived virus to the parental RB-1B strain, we modified the existing pRB-1B5 clone by restoring the Us2 and by introducing SV40-cre cassette within the loxP sites of the mini-F plasmid, to allow self-excision of the plasmid sequences in chicken cells.
  • Excision of the BAC sequences also enhanced the pathogenicity to levels similar to that of the parental virus, as the cumulative incidence of Marek's disease in groups infected with the recombinant and the parental viruses showed no significant differences.
  • Thus, we have been able to make significant improvements to the existing BAC clone of this highly oncogenic virus which would certainly increase its usefulness as a valuable tool for studies on identifying the oncogenic determinants of this major avian pathogen.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Herpesvirus 2, Gallid / physiology. Marek Disease / virology

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  • (PMID = 18230192.001).
  • [ISSN] 1743-422X
  • [Journal-full-title] Virology journal
  • [ISO-abbreviation] Virol. J.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / BB/C506448/1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2248170
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60. Feng J, Vick BA, Lee MK, Zhang HB, Jan CC: Construction of BAC and BIBAC libraries from sunflower and identification of linkage group-specific clones by overgo hybridization. Theor Appl Genet; 2006 Jun;113(1):23-32
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  • [Title] Construction of BAC and BIBAC libraries from sunflower and identification of linkage group-specific clones by overgo hybridization.
  • Complementary BAC and BIBAC libraries were constructed from nuclear DNA of sunflower cultivar HA 89.
  • The BAC library, constructed with BamHI in the pECBAC1 vector, contains 107,136 clones and has an average insert size of 140 kb.
  • The frequencies of BAC and BIBAC clones carrying chloroplast or mitochondrial DNA sequences were estimated to be 2.35 and 0.04%, respectively, and insert-empty clones were less than 0.5%.
  • Thirty-six overgos were designed and pooled as probes to screen a subset (5.1x) of the BAC and BIBAC libraries.
  • As a result, 195 BAC and BIBAC clones representing 19 linkage groups were identified, including 76 BAC clones and 119 BIBAC clones, further verifying the genome coverage and utility of the libraries.
  • These BAC and BIBAC libraries and linkage group-specific clones provide resources essential for comprehensive research of the sunflower genome.
  • [MeSH-minor] Chromosome Mapping. Chromosomes, Artificial, Bacterial / genetics. Cloning, Molecular. DNA, Plant / genetics. Gene Library. Nucleic Acid Hybridization

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  • (PMID = 16612648.001).
  • [ISSN] 0040-5752
  • [Journal-full-title] TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
  • [ISO-abbreviation] Theor. Appl. Genet.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Plant
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61. Tian JY, Chen ZL, Yang YL, Liang H, Nan J, Wang ZZ, Li GB: Hybrid process of BAC and sMBR for treating polluted raw water. Bioresour Technol; 2009 Dec;100(24):6243-9
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  • [Title] Hybrid process of BAC and sMBR for treating polluted raw water.
  • The hybrid process of biological activated carbon (BAC) and submerged membrane bioreactor (sMBR) was evaluated for the drinking water treatment from polluted raw water, with the respective hydraulic retention time of 0.5 h.
  • The results confirmed the synergetic effects between the BAC and the subsequent sMBR.
  • A moderate amount of ammonium (54.5%) was decreased in the BAC; while the total removal efficiency was increased to 89.8% after the further treatment by the sMBR.
  • In the hybrid process, adsorption of granular activated carbon (in BAC), two stages of biodegradation (in BAC and sMBR), and separation by the membrane (in sMBR) jointly contributed to the removal of organic matter.
  • Due to the pre-treatment effect of BAC, the membrane fouling in the downstream sMBR was substantially mitigated.

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  • (PMID = 19682892.001).
  • [ISSN] 1873-2976
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membranes, Artificial; 0 / Nitrates; 0 / Organic Chemicals; 0 / Quaternary Ammonium Compounds; 0 / Water Pollutants, Chemical; 16291-96-6 / Charcoal
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62. Chandler KJ, Chandler RL, Broeckelmann EM, Hou Y, Southard-Smith EM, Mortlock DP: Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression. Mamm Genome; 2007 Oct;18(10):693-708
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression.
  • Bacterial artificial chromosomes (BACs) are excellent tools for manipulating large DNA fragments and, as a result, are increasingly utilized to engineer transgenic mice by pronuclear injection.
  • The demand for BAC transgenic mice underscores the need for careful inspection of BAC integrity and fidelity following transgenesis, which may be crucial for interpreting transgene function.
  • However, there are limited data regarding whether BAC transgenes routinely integrate in the mouse genome as intact molecules, how BAC transgenes behave as they are passed through the germline across successive generations, and how variation in BAC transgene copy number relates to transgene expression.
  • To address these questions, we used TaqMan real-time PCR to estimate BAC transgene copy number in BAC transgenic embryos and lines.
  • In addition, polymorphic marker analysis suggests that the majority of BAC transgenic lines contain intact molecules.
  • Notably, all lines containing multiple BAC copies also contain all BAC-specific markers.
  • Three of 23 founders analyzed contained BAC transgenes integrated into more than one genomic location.
  • Finally, we show increased BAC transgene copy number correlates with increased BAC transgene expression.
  • In sum, our efforts have provided a reliable method for assaying BAC transgene integrity and fidelity, and data that should be useful for researchers using BACs as transgenic vectors.
  • [MeSH-major] Chromosomes, Artificial, Bacterial

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  • (PMID = 17882484.001).
  • [ISSN] 0938-8990
  • [Journal-full-title] Mammalian genome : official journal of the International Mammalian Genome Society
  • [ISO-abbreviation] Mamm. Genome
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD007502; United States / NICHD NIH HHS / HD / T32 HD007502-08; United States / NIGMS NIH HHS / GM / T32 GM062758; United States / NIAMS NIH HHS / AR / R01 AR049529; United States / NIGMS NIH HHS / GM / 1T32GM62758-03; United States / NICHD NIH HHS / HD / R01 HD047880-01; United States / NICHD NIH HHS / HD / 5T32HD07502-08; United States / NIDDK NIH HHS / DK / R21 DK064251; United States / NIDDK NIH HHS / DK / R21 DK064251-01S1; United States / NIGMS NIH HHS / GM / T32 GM062758-03; United States / NICHD NIH HHS / HD / 1R01HD47880-01; United States / NIDDK NIH HHS / DK / R21 DK064251-01; United States / NICHD NIH HHS / HD / R01 HD047880; United States / NIAMS NIH HHS / AR / R01 AR049529-04; United States / NIDDK NIH HHS / DK / R21 DK064251-02; United States / NIAMS NIH HHS / AR / 5R01AR049529-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA; 9012-36-6 / Sepharose
  • [Other-IDs] NLM/ NIHMS293875; NLM/ PMC3110064
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63. Lu XH: BAC to degeneration bacterial artificial chromosome (BAC)-mediated transgenesis for modeling basal ganglia neurodegenerative disorders. Int Rev Neurobiol; 2009;89:37-56
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  • [Title] BAC to degeneration bacterial artificial chromosome (BAC)-mediated transgenesis for modeling basal ganglia neurodegenerative disorders.
  • Basal ganglia neurodegenerative disorders, such as Parkinson's disease (PD) and Huntington's disease (HD), are characterized by not only spectrum of motor deficits, ranging form hypokinesia to hyperkinesia, but also emotional, cognitive, and psychiatric manifestations.
  • Transgenic approaches using large genomic inserts, such as bacterial artificial chromosome (BAC)-mediated transgenesis, due to its capacity to propagate large-size genomic DNA and faithful production of endogenous-like gene expression pattern/lever, have provided an ideal basis for the generation of transgenic mice as model for basal ganglia neurodegenerative disorders, as well as the functional and structural analysis of neurocircuits.
  • In this chapter, the basic concepts and practical approaches about application of BAC transgenic system are introduced.
  • Existent major BAC transgenic mouse models for PD and HD are evaluated according to their construct, face, and predicative validity.
  • Finally, considerations, possible solutions, and future perspectives of using BAC transgenic approach to study basal ganglia neurodegenerative disorders are discussed.
  • [MeSH-major] Basal Ganglia Diseases / genetics. Chromosomes, Artificial, Bacterial / genetics. Neurodegenerative Diseases / genetics
  • [MeSH-minor] Animals. Disease Models, Animal. Humans. Huntington Disease / genetics. Huntington Disease / pathology. Mice. Mice, Transgenic. Parkinson Disease / genetics. Parkinson Disease / pathology

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  • (PMID = 19900614.001).
  • [ISSN] 0074-7742
  • [Journal-full-title] International review of neurobiology
  • [ISO-abbreviation] Int. Rev. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 117
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64. Li L, Zhu W, Zhang P, Zhang Q, Zhang Z: TiO2/UV/O3-BAC processes for removing refractory and hazardous pollutants in raw water. J Hazard Mater; 2006 Feb 6;128(2-3):145-9
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  • [Title] TiO2/UV/O3-BAC processes for removing refractory and hazardous pollutants in raw water.
  • TiO2/UV/O3-BAC (biological activated carbon) process was employed to treat raw water and compared to UV/O3-BAC process in its optimum parameters (3 mg/L ozone dosage with 15 min oxidation time and 15 min empty bed contact time in BAC).
  • For the dissolved organic carbon (DOC) removal, TiO2/UV/O3-BAC was more efficient than UV/O3-BAC and its synergetic effect is more than that in UV/O(3)-BAC process.
  • GC/MS analysis showed that TiO2/UV/O3-BAC process was effective in removing phthalate esters (PAEs) and persistent organic pollutants (POPs).
  • TiO2/UV/O3-BAC process was also very effective in removing POPs.

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  • (PMID = 16257116.001).
  • [ISSN] 0304-3894
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Phthalic Acids; 0 / Water Pollutants; 15FIX9V2JP / titanium dioxide; 16291-96-6 / Charcoal; 66H7ZZK23N / Ozone; 6O7F7IX66E / phthalic acid; D1JT611TNE / Titanium
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65. Reed KM, Faile GM, Kreuth SB, Chaves LD, Sullivan LM: Association and in silico assignment of sequences from turkey BACs. Anim Biotechnol; 2008;19(2):80-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association and in silico assignment of sequences from turkey BACs.
  • Bacterial artificial chromosomes (BACs) provide an important resource in genetic mapping.
  • An initial set of BACs corresponding to microsatellite markers in the turkey (Meleagris gallopavo) was isolated from the CHORI-260 turkey BAC library.
  • End sequences were obtained for a subset of the recovered BACs and compared to the chicken whole genome sequence.
  • Close association of the turkey BAC-end sequences and original marker sequences was generally conserved in the chicken genome.
  • Gene content of the turkey BACs is predicted from the comparative sequence alignments.
  • [MeSH-major] Chromosome Mapping / veterinary. Chromosomes, Artificial, Bacterial / genetics. Turkeys / genetics

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  • (PMID = 18432398.001).
  • [ISSN] 1532-2378
  • [Journal-full-title] Animal biotechnology
  • [ISO-abbreviation] Anim. Biotechnol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
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66. Li L, Zhu W, Zhang P, Zhang Z, Wu H, Han W: Comparison of AC/O3-BAC and O3-BAC processes for removing organic pollutants in secondary effluent. Chemosphere; 2006 Mar;62(9):1514-22
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  • [Title] Comparison of AC/O3-BAC and O3-BAC processes for removing organic pollutants in secondary effluent.
  • AC (activated carbon)/O3-BAC (biological activated carbon) process was employed to treat secondary effluent and compared to O3-BAC process.
  • The effects of ozone dosages and empty bed contact time (EBCT) in BAC on dissolved organic carbon (DOC) removal were investigated.
  • DOC removal increased with ozone dosage and EBCT in BAC, however, 3 mg l(-1) ozone dosage with 15 min oxidation time and 15 min EBCT in BAC were more economical and efficient.
  • For DOC removal, AC/O3-BAC was more efficient than O3-BAC and its synergetic effect was more than that in O3-BAC process.
  • The biomass of the subsequent BAC unit in AC/O3-BAC process was more than that in O3-BAC process and much more than that in BAC alone.
  • However, some small molecules were generated, after further biological treatment by BAC, the kinds and concentration of organic compounds were greatly reduced.

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  • (PMID = 16087215.001).
  • [ISSN] 0045-6535
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organic Chemicals; 0 / Water Pollutants, Chemical; 66H7ZZK23N / Ozone; 7440-44-0 / Carbon
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67. Zhdanova NS: [Comparative mapping of mink (Mustela vison) chromosome 8p: localization of three human BAC clones]. Genetika; 2007 Aug;43(8):1074-8
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  • [Title] [Comparative mapping of mink (Mustela vison) chromosome 8p: localization of three human BAC clones].
  • Using fluorescent in situ hybridization (FISH), three human BAC clones, localized in the terminal region of human chromosome 17p (HSA17p13; 1.44--3.68 Mp), were mapped to chromosome 8p of American mink (MVI8p).
  • It was demonstrated that in MVI8p the region, homeologous to HSA17p13, was split into three fragments, which were detected within terminal, pericentric, and probably nucleolus-organizing regions.
  • Using human BAC clones as heterologous markers for mapping of the gene sequences to the chromosomes of American mink, regional localization of eight sequences (PRPF8, SLC43A2, and RILP in MVI8p25; C17orf31 in MVI8p21-22; and CTNS, TAX1BP3, and P2RX5 in MVI8p11) was deduced.
  • [MeSH-minor] Animals. Chromosomes, Artificial, Bacterial / genetics. Genetic Markers. Humans. In Situ Hybridization, Fluorescence

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  • (PMID = 17958307.001).
  • [ISSN] 0016-6758
  • [Journal-full-title] Genetika
  • [ISO-abbreviation] Genetika
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Genetic Markers
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68. Niemi RM, Heiskanen I, Heine R, Rapala J: Previously uncultured beta-Proteobacteria dominate in biologically active granular activated carbon (BAC) filters. Water Res; 2009 Dec;43(20):5075-86
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  • [Title] Previously uncultured beta-Proteobacteria dominate in biologically active granular activated carbon (BAC) filters.
  • Bacteria colonizing BAC filters used in drinking water purification from lake water were characterized by morphology, physiological tests, whole cell protein profiles and PLFA (phospholipid fatty acid) composition, and identified by partial 16S rRNA gene sequencing.
  • Epifluorescence revealed prothecate bacteria to dominate in BAC.
  • The majority of cultured bacteria persisting in the BAC biofilter were Burkholderiales, which according to ecological information are efficient in the mineralisation of dissolved organic matter in BAC.

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  • (PMID = 19783028.001).
  • [ISSN] 1879-2448
  • [Journal-full-title] Water research
  • [ISO-abbreviation] Water Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Ribosomal, 16S; 16291-96-6 / Charcoal
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69. Nowak NJ, Snijders AM, Conroy JM, Albertson DG: The BAC resource: tools for array CGH and FISH. Curr Protoc Hum Genet; 2005 Aug;Chapter 4:Unit 4.13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The BAC resource: tools for array CGH and FISH.
  • Bacterial Artificial Chromosome (BAC) vector clones carrying human DNA were chosen as the intermediate templates for the sequencing of the human genome due to their inherent stability and fidelity to the genome sequence from which they were derived.
  • In this unit, we describe a set of protocols for BAC-based array comparative genomic hybridization (aCGH) that comprise the generation of targets for printing solutions onto glass slides, the subsequent hybridization steps, and CGH analysis of a test sample compared to a reference normal sample.
  • The BAC clones through their sequence allow the extent and gene content of numerical aberrations to be delineated by aCGH, and also provide cytogeneticists with tools for subsequent validation or fine mapping studies.

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  • (PMID = 18428377.001).
  • [ISSN] 1934-8258
  • [Journal-full-title] Current protocols in human genetics
  • [ISO-abbreviation] Curr Protoc Hum Genet
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Sparwasser T, Eberl G: BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells. Immunology; 2007 Jul;121(3):308-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells.
  • A powerful development is the bacterial artificial chromosome (BAC) transgenic approach, combining advantages of both conventional transgenic and knock-in gene-targeting strategies.
  • In immunology the potential of BAC transgenic technology has yet to be fully harvested and, combined with a variety of elegant genetic tools, it will allow the analysis of complex immunological processes in vivo.
  • In this short review, we discuss the applications of BACs in immunology, such as identification of regulatory regions, expression and cell-fate mapping, cell ablation, conditional mutations and the generation of humanized mice.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / immunology. Gene Transfer Techniques
  • [MeSH-minor] Animals. Disease Models, Animal. Gene Targeting. Mice. Mice, Transgenic

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  • (PMID = 17437533.001).
  • [ISSN] 0019-2805
  • [Journal-full-title] Immunology
  • [ISO-abbreviation] Immunology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 43
  • [Other-IDs] NLM/ PMC2265958
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71. Gong S, Yang XW: Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice. Curr Protoc Neurosci; 2005 May;Chapter 5:Unit 5.21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice.
  • BAC transgenesis is a powerful tool for the study of gene expression and gene function in the mouse in vivo.
  • In this unit, detailed protocols are provided for modification (i.e., marker gene insertion, deletion, or point mutation) of BACs by homologous recombination in E. coli.
  • This method utilizes a shuttle vector that allows transient expression of the E. coli RecA gene to support homologous recombination in the BAC host bacteria.
  • In addition, two protocols are provided for purification of BAC DNA for microinjection to generate transgenic mice.
  • Since BAC DNA is prone to degradation, which may introduce positional effects in transgenic mice, two methods are given for purification of intact BAC DNA for subsequent microinjection.

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  • (PMID = 18428623.001).
  • [ISSN] 1934-8576
  • [Journal-full-title] Current protocols in neuroscience
  • [ISO-abbreviation] Curr Protoc Neurosci
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Takahashi R, Ueda M: Generation of transgenic rats using YAC and BAC DNA constructs. Methods Mol Biol; 2010;597:93-108
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Generation of transgenic rats using YAC and BAC DNA constructs.
  • Vectors derived from yeast artificial chromosome (YAC) and bacterial artificial chromosome (BAC), consisting of DNA fragments up to approximately 1 Mb (YAC) and approximately 200 Kb (BAC), respectively, and containing various endogenous regulatory sequences, were expected to work well and showed expression profiles comparable to their endogenous counterparts in transgenic animals.
  • While attempting to make transgenic rats using YAC and BAC vectors, we faced two problems: how to prepare sufficiently concentrated intact DNA and how to reliably microinject a large DNA fragment into the fragile pronuclear ova of the rat.
  • After solving these problems, we were able to make transgenic rats by introducing YAC/BAC gene constructs (YACs/BACs) into the pronuclear ova.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Chromosomes, Artificial, Yeast / genetics. DNA / administration & dosage. Microinjections / methods. Rats, Transgenic / genetics

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  • (PMID = 20013228.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-49-2 / DNA
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73. Ge Y, He G, Wang Z, Guo D, Qin R, Li R: GISH and BAC-FISH study of apomictic Beta M14. Sci China C Life Sci; 2007 Apr;50(2):242-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] GISH and BAC-FISH study of apomictic Beta M14.
  • We analyzed BAC microarrays of B. corolliflora chromosome 9 by using fluorescence-specific mRNA of B. vulgaris and Beta M14.
  • BAC clones 16-M11 and 26-L15 were detected as fluorescence-specifics of BAC DNA of Beta M14.
  • Then both BAC clones 16-M11 and 26-L15 were in situ hybridized to M14 chromosomes.
  • The two hybridized BAC clones were located close to the telomere region of the long arm of a single chromosome 9, and showed hemizygosity.
  • The results of BAC microarrays showed that these developments of embryo and endosperm have conservative expression patterns, indicating that sexual reproduction and apomixis have an interrelated pathway with common regulatory components and that the induction of a modified sexual reproduction program may enable the manifestation of apomixis in Beta species.

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  • (PMID = 17447032.001).
  • [ISSN] 1006-9305
  • [Journal-full-title] Science in China. Series C, Life sciences
  • [ISO-abbreviation] Sci. China, C, Life Sci.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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74. Liu H, Jiang Y, Wang S, Ninwichian P, Somridhivej B, Xu P, Abernathy J, Kucuktas H, Liu Z: Comparative analysis of catfish BAC end sequences with the zebrafish genome. BMC Genomics; 2009;10:592
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of catfish BAC end sequences with the zebrafish genome.
  • This project was initiated to generate additional BAC end sequences and demonstrate their applications in comparative mapping in catfish.
  • RESULTS: We reported the generation of 43,000 BAC end sequences and their applications for comparative genome analysis in catfish.
  • Using these and the additional 20,000 existing BAC end sequences as a resource along with linkage mapping and existing physical map, conserved syntenic regions were identified between the catfish and zebrafish genomes.
  • A total of 10,943 catfish BAC end sequences (17.3%) had significant BLAST hits to the zebrafish genome (cutoff value <or= e(-5)), of which 3,221 were unique gene hits, providing a platform for comparative mapping based on locations of these genes in catfish and zebrafish.
  • CONCLUSION: BAC end sequences and their associated polymorphic markers are great resources for comparative genome analysis in catfish.
  • [MeSH-major] Catfishes / genetics. Chromosomes, Artificial, Bacterial / genetics. Genome / genetics. Zebrafish / genetics

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  • (PMID = 20003258.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2796685
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75. Hill SK, Sweeney JA, Hamer RM, Keefe RS, Perkins DO, Gu H, McEvoy JP, Lieberman JA: Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia. J Int Neuropsychol Soc; 2008 Mar;14(2):209-21
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  • [Title] Efficiency of the CATIE and BACS neuropsychological batteries in assessing cognitive effects of antipsychotic treatments in schizophrenia.
  • Participants were primarily first episode schizophrenia patients who completed baseline (n = 367) and 12-week (n = 219) assessments with the BACS (Brief Assessment of Cognition in Schizophrenia) and CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) neuropsychological batteries in a clinical trial comparing olanzapine, quetiapine, and risperidone.
  • Both batteries estimated similar levels of change following treatment, although the BACS battery required half the administration time.
  • Because a unitary factor characterized baseline cognitive abilities in early psychosis as well as cognitive change after treatment with atypical antipsychotic medications, short batteries such as the BACS may efficiently provide sufficient assessment of procognitive treatment effects with antipsychotic medications.

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  • (PMID = 18282319.001).
  • [ISSN] 1469-7661
  • [Journal-full-title] Journal of the International Neuropsychological Society : JINS
  • [ISO-abbreviation] J Int Neuropsychol Soc
  • [Language] ENG
  • [Grant] None / None / / N01 MH90001; United States / NIMH NIH HHS / MH / N01 MH90001
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antidiarrheals
  • [Other-IDs] NLM/ NIHMS297860; NLM/ PMC3138071
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76. Zheng Y, Cai J, Li J, Li B, Lin R, Tian F, Wang X, Wang J: Sequencing, annotation and comparative analysis of nine BACs of giant panda (Ailuropoda melanoleuca). Sci China Life Sci; 2010 Jan;53(1):107-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sequencing, annotation and comparative analysis of nine BACs of giant panda (Ailuropoda melanoleuca).
  • A 10-fold BAC library for giant panda was constructed and nine BACs were selected to generate finish sequences.
  • These BACs could be used as a validation resource for the de novo assembly accuracy of the whole genome shotgun sequencing reads of giant panda newly generated by the Illumina GA sequencing technology.
  • Complete sanger sequencing, assembly, annotation and comparative analysis were carried out on the selected BACs of a joint length 878 kb.
  • Homologue search and de novo prediction methods were used to annotate genes and repeats.
  • About 27 percent of the BAC sequence is composed of repeats.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Genomic Library. Sequence Analysis, DNA / methods. Ursidae / genetics

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  • (PMID = 20596962.001).
  • [ISSN] 1869-1889
  • [Journal-full-title] Science China. Life sciences
  • [ISO-abbreviation] Sci China Life Sci
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ GQ181172/ GQ181173/ GQ181174/ GQ181175/ GQ181176/ GQ181177/ GQ181178/ GQ181179/ GQ181180
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Untranslated
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77. Mathewson CA, Schein JE, Marra MA: Large-scale BAC clone restriction digest fingerprinting. Curr Protoc Hum Genet; 2007 Apr;Chapter 5:Unit 5.19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Large-scale BAC clone restriction digest fingerprinting.
  • Restriction digest fingerprinting is a common method for characterizing large insert genomic clones, e.g., bacterial artificial chromosome (BAC), P1 artificial chromosome (PAC) and Fosmid clones.
  • This unit describes a robust, large-scale procedure for generation of agarose gel-based clone fingerprints from BAC clones.

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  • (PMID = 18428413.001).
  • [ISSN] 1934-8258
  • [Journal-full-title] Current protocols in human genetics
  • [ISO-abbreviation] Curr Protoc Hum Genet
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.21.- / DNA Restriction Enzymes
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78. Zhang X, Scheuring C, Tripathy S, Xu Z, Wu C, Ko A, Tian SK, Arredondo F, Lee MK, Santos FA, Jiang RH, Zhang HB, Tyler BM: An integrated BAC and genome sequence physical map of Phytophthora sojae. Mol Plant Microbe Interact; 2006 Dec;19(12):1302-10
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  • [Title] An integrated BAC and genome sequence physical map of Phytophthora sojae.
  • Here, we report a bacterial artificial chromosome (BAC)-based, integrated physical map of the P. sojae genome.
  • We constructed two BAC libraries, digested 8,681 BACs with seven restriction enzymes, end labeled the digested fragments with four dyes, and analyzed them with capillary electrophoresis.
  • The BAC contigs were integrated with the draft genome sequence of P. sojae by end sequencing a total of 1,440 BACs that formed a minimal tiling path.
  • This enabled the 257 contigs of the BAC map to be merged with 207 sequence scaffolds to form an integrated map consisting of 79 superscaffolds.
  • The map represents the first genome-wide physical map of a Phytophthora sp. and provides a valuable resource for genomics and molecular biology research in P. sojae and other Phytophthora spp.
  • In one illustration of this value, we have placed the 350 members of a superfamily of putative pathogenicity effector genes onto the map, revealing extensive clustering of these genes.
  • [MeSH-major] Chromosomes, Artificial, Bacterial. Contig Mapping. Genome. Phytophthora / genetics

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  • (PMID = 17153914.001).
  • [ISSN] 0894-0282
  • [Journal-full-title] Molecular plant-microbe interactions : MPMI
  • [ISO-abbreviation] Mol. Plant Microbe Interact.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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79. Song H, Chung SK, Xu Y: Modeling disease in human ESCs using an efficient BAC-based homologous recombination system. Cell Stem Cell; 2010 Jan 8;6(1):80-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modeling disease in human ESCs using an efficient BAC-based homologous recombination system.
  • Although mouse models have been valuable for studying human disease, the cellular and physiological differences between mouse and human have made it increasingly important to develop more relevant human disease models for mechanistic studies and drug discovery.
  • Human embryonic stem cells (hESCs), which can undergo unlimited self-renewal and retain the potential to differentiate into all cell types, present a possible solution.
  • To improve the efficiency of genetic manipulation of hESCs, we have developed bacterial artificial chromosome (BAC) based approach that enables high efficiency homologous recombination.
  • By sequentially disrupting both alleles of ATM or p53 with BAC targeting vectors, we have established ATM(-/-) and p53(-/-) hESCs as models for two major human genetic instability syndromes and used the generated cells to reveal the importance of p53 in maintaining genome stability of hESCs.
  • Our findings suggest that it will be feasible to develop genetically modified hESCs as relevant human disease models.
  • [MeSH-major] Chromosomes, Bacterial / genetics. Embryonic Stem Cells / metabolism. Recombination, Genetic
  • [MeSH-minor] Animals. Ataxia Telangiectasia Mutated Proteins. Cell Cycle Proteins / genetics. Cell Cycle Proteins / metabolism. Cell Differentiation / radiation effects. Cells, Cultured. DNA Damage. DNA-Binding Proteins / genetics. DNA-Binding Proteins / metabolism. Genetic Vectors. Genomic Instability. Humans. Male. Mice. Mice, SCID. Protein-Serine-Threonine Kinases / genetics. Protein-Serine-Threonine Kinases / metabolism. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism. Tumor Suppressor Proteins / genetics. Tumor Suppressor Proteins / metabolism

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20074536.001).
  • [ISSN] 1875-9777
  • [Journal-full-title] Cell stem cell
  • [ISO-abbreviation] Cell Stem Cell
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / DNA-Binding Proteins; 0 / Tumor Suppressor Protein p53; 0 / Tumor Suppressor Proteins; EC 2.7.11.1 / ATM protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Atm protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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80. Jakse J, Telgmann A, Jung C, Khar A, Melgar S, Cheung F, Town CD, Havey MJ: Comparative sequence and genetic analyses of asparagus BACs reveal no microsynteny with onion or rice. Theor Appl Genet; 2006 Dec;114(1):31-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative sequence and genetic analyses of asparagus BACs reveal no microsynteny with onion or rice.
  • We sequenced nine asparagus BACs to reveal physically linked genic-like sequences and determined their most similar positions in the onion and rice genomes.
  • Four of the asparagus BACs were selected using molecular markers tightly linked to the sex-determining M locus on chromosome 5 of asparagus.
  • These BACs possessed only two putative coding regions and had long tracts of degenerated retroviral elements and transposons.
  • Five asparagus BACs were selected after hybridization of three onion cDNAs that mapped to three different onion chromosomes.
  • Genic-like sequences that were physically linked on the cDNA-selected BACs or genetically linked on the M-linked BACs showed significant similarities (e < -20) to expressed sequences on different rice chromosomes, revealing no evidence for microsynteny between asparagus and rice across these regions.
  • [MeSH-minor] Chromosome Mapping. Chromosomes, Artificial, Bacterial. DNA, Complementary. DNA, Plant / genetics. Genome, Plant. Genomics. Sequence Analysis, DNA

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  • (PMID = 17016688.001).
  • [ISSN] 0040-5752
  • [Journal-full-title] TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
  • [ISO-abbreviation] Theor. Appl. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA, Plant
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81. Ratnakumar A, Barris W, McWilliam S, Brauning R, McEwan JC, Snelling WM, Dalrymple BP: A multiway analysis for identifying high integrity bovine BACs. BMC Genomics; 2009;10:46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A multiway analysis for identifying high integrity bovine BACs.
  • BACKGROUND: In large genomics projects involving many different types of analyses of bacterial artificial chromosomes (BACs), such as fingerprinting, end sequencing (BES) and full BAC sequencing there are many opportunities for the identities of BACs to become confused.
  • However, by comparing the results from the different analyses, inconsistencies can be identified and a set of high integrity BACs preferred for future research can be defined.
  • RESULTS: The location of each bovine BAC in the BAC fingerprint-based genome map and in the genome assembly were compared based on the reported BESs, and for a smaller number of BACs the full sequence.
  • BACs with consistent positions in all three datasets, or if the full sequence was not available, for both the fingerprint map and BES-based alignments, were deemed to be correctly positioned.
  • BACs with consistent BES-based and fingerprint-based locations, but with conflicting locations based on the fully sequenced BAC, appeared to have been misidentified during sequencing, and included a number of apparently swapped BACs.
  • Inconsistencies between BES-based and fingerprint map positions identified thirty one plates from the CHORI-240 library that appear to have suffered substantial systematic problems during the end-sequencing of the BACs.
  • No systematic problems were identified in the fingerprinting of the BACs.
  • Analysis of BACs overlapping in the assembly identified a small overrepresentation of clones with substantial overlap in the library and a substantial enrichment of highly overlapping BACs on the same plate in the CHORI-240 library.
  • More than half of these BACs appear to have been present as duplicates on the original BAC-library plates and thus should be avoided in subsequent projects.
  • CONCLUSION: Our analysis shows that approximately 95% of the bovine CHORI-240 library clones with both a BAC fingerprint and two BESs mapping to the genome in the expected orientations (approximately 27% of all BACs) have consistent locations in the BAC fingerprint map and the genome assembly.
  • We have developed a broadly applicable methodology for checking the integrity of BAC-based datasets even where only incomplete and partially assembled genomic sequence is available.
  • [MeSH-major] Cattle / genetics. Chromosomes, Artificial, Bacterial / genetics. Genome. Genomics / methods

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  • (PMID = 19166603.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Genetic Markers
  • [Other-IDs] NLM/ PMC2660975
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82. Desapriya EB, Shimizu S, Pike I, Smith D: Impact of lowering the legal BAC limit to .03 on teenage drinking and driving related crashes in Japan. Nihon Arukoru Yakubutsu Igakkai Zasshi; 2006 Dec;41(6):513-27
Hazardous Substances Data Bank. ETHANOL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of lowering the legal BAC limit to .03 on teenage drinking and driving related crashes in Japan.
  • Most notably, the legal BAC limit for driving lowered from 0.05 mg/ml to 0.03 mg/ml.
  • The rationale for the new lower BAC limit in Japan was predicated on the assumption that drinking drivers will comply with the new lower limit by reducing the amount of alcohol they consume prior to driving, thereby lowering their risk of crash involvement.
  • The chief objective of this research is to quantify the extent to which lowering the legal limit of BAC has reduced teenager involved motor vehicle injuries and fatalities in Japan since 2002.
  • Most notably, the introduction of reduced BAC limit legislation resulted in a statistically significant decrease in the number of alcohol impaired young drivers on the road in Japan, indicating responsiveness to the legal change among this group.
  • Since the introduction of the 0.03 BAC law, statistically significant decreases were observed in alcohol-related crashes, alcohol related injuries and single vehicle night time crashes among 16-19 year old drivers, as we hypothesized.
  • In comparison, the rates of total crashes, injuries and pedestrian fatalities showed no statistically significant decline or increase in the period following the introduction of the BAC law.


83. Liang CH, Chiang PC: Mathematical model of the non-steady-state adsorption and biodegradation capacities of BAC filters. J Hazard Mater; 2007 Jan 10;139(2):316-22
Hazardous Substances Data Bank. ACTIVATED CHARCOAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mathematical model of the non-steady-state adsorption and biodegradation capacities of BAC filters.
  • This research was focused on developing a non-steady-state numerical model to differentiate the adsorption and biodegradation quantities of a biological activated carbon (BAC) column.
  • The biofilm developed around the BAC granules can hinder the mass transfer of the substrate onto the GAC surface, and the adsorption process will be restricted by the biofilm thickness.

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  • (PMID = 16860932.001).
  • [ISSN] 0304-3894
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 16291-96-6 / Charcoal
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84. Kuchenbeiser G, Soleilhavoup M, Donnadieu B, Bertrand G: Reactivity of cyclic (alkyl)(amino)carbenes (CAACs) and bis(amino)cyclopropenylidenes (BACs) with heteroallenes: comparisons with their N-heterocyclic carbene (NHCs) counterparts. Chem Asian J; 2009 Nov 2;4(11):1745-50
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reactivity of cyclic (alkyl)(amino)carbenes (CAACs) and bis(amino)cyclopropenylidenes (BACs) with heteroallenes: comparisons with their N-heterocyclic carbene (NHCs) counterparts.
  • Similarly to NHCs, CAAC(a) and BAC(a) react with CO2 to give the corresponding betaines.
  • Based on the carbonyl stretching frequencies of cis-[RhCl(CO)2(L)] complexes, the order of electron donor ability was predicted to be CAAC(a) approximately BAC(a)>NHCs.
  • When the betaines nu(asym)(CO2) values are used, the apparent ordering is BAC(a)>NHCs approximately CAAC(a) that indicates a limitation for the use of IR spectroscopy in the ranking of ligand sigma-donating ability.
  • Although all carbenes react with carbon disulfide to give the corresponding betaines, a second equivalent of CS2 reacts with the BAC-CS2 leading to a bicyclic thieno[2,3-diamino]-1,3-dithiole-2-thione, which results from a novel ring expansion process.
  • Surprisingly, in contrast to NHCs, CAAC(a) does not react with carbodiimide, whereas BAC(a) exclusively gives a ring expanded product, analogous to that obtained with CS2.
  • The intermediate amidinate can be trapped, using the lithium tetrafluoroborate adduct of BAC(b) as a carbene surrogate.

  • Hazardous Substances Data Bank. PROPADIENE .
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  • (PMID = 19780080.001).
  • [ISSN] 1861-471X
  • [Journal-full-title] Chemistry, an Asian journal
  • [ISO-abbreviation] Chem Asian J
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / GM068825-05; United States / NIGMS NIH HHS / GM / R01 GM068825; United States / NIGMS NIH HHS / GM / R01 GM 68825; United States / NIGMS NIH HHS / GM / R01 GM068825-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Alkadienes; 0 / Alkynes; 0 / Cyclopropanes; 0 / Dioxolanes; 0 / Heterocyclic Compounds; 0 / aminocarbene; 4AV0LZ8QKB / propadiene
  • [Other-IDs] NLM/ NIHMS201192; NLM/ PMC2869243
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85. Lichtenzveig J, Scheuring C, Dodge J, Abbo S, Zhang HB: Construction of BAC and BIBAC libraries and their applications for generation of SSR markers for genome analysis of chickpea, Cicer arietinum L. Theor Appl Genet; 2005 Feb;110(3):492-510
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Construction of BAC and BIBAC libraries and their applications for generation of SSR markers for genome analysis of chickpea, Cicer arietinum L.
  • Large-insert bacterial artificial chromosome (BAC) libraries, plant-transformation-competent binary BAC (BIBAC) libraries, and simple sequence repeat (SSR) markers are essential for many aspects of genomics research.
  • We constructed a BAC library and a BIBAC library from the nuclear DNA of chickpea, Cicer arietinum L., cv.
  • The BAC library has 14,976 clones, with an average insert size of 121 kb, and the BIBAC library consists of 23,040 clones, with an average insert size of 145 kb.
  • We screened the BAC library with eight synthetic SSR oligos, (GA)10, (GAA)7, (AT)10, (TAA)7, (TGA)7, (CA)10, (CAA)7, and (CCA)7.
  • Positive BACs were selected, subcloned, and sequenced for SSR marker development.
  • These results have demonstrated that BACs are an excellent source for SSR marker development in chickpea.
  • The BAC and BIBAC libraries and new SSR markers will provide valuable resources for chickpea genomics research and breeding (the libraries and their filters are available to the public at http://hbz.tamu.edu).
  • [MeSH-minor] Base Sequence. Chromosomes, Artificial, Bacterial. Cloning, Molecular. DNA Primers. Minisatellite Repeats / genetics. Molecular Sequence Data. Oligonucleotides. Sequence Analysis, DNA

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  • (PMID = 15712010.001).
  • [ISSN] 0040-5752
  • [Journal-full-title] TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
  • [ISO-abbreviation] Theor. Appl. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Genetic Markers; 0 / Oligonucleotides
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86. Soler L, Conte MA, Katagiri T, Howe AE, Lee BY, Amemiya C, Stuart A, Dossat C, Poulain J, Johnson J, Di Palma F, Lindblad-Toh K, Baroiller JF, D'Cotta H, Ozouf-Costaz C, Kocher TD: Comparative physical maps derived from BAC end sequences of tilapia (Oreochromis niloticus). BMC Genomics; 2010;11:636
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative physical maps derived from BAC end sequences of tilapia (Oreochromis niloticus).
  • Here we analyze BAC end-sequences to develop comparative physical maps, and estimate the number of genome rearrangements, between tilapia and other model fish species.
  • RESULTS: We obtained sequence from one or both ends of 106,259 tilapia BACs.
  • BLAST analysis against the genome assemblies of stickleback, medaka and pufferfish allowed identification of homologies for approximately 25,000 BACs for each species.
  • The paired BAC end sequences from these clones will be an important resource for scaffolding forthcoming shotgun sequence assemblies of the tilapia genome.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Cichlids / genetics. Physical Chromosome Mapping. Sequence Analysis, DNA / methods

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  • (PMID = 21080946.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
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FQ243532/ FQ243533/ FQ243534/ FQ243535/ FQ243536
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD058635
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fish Proteins
  • [Other-IDs] NLM/ PMC3018143
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87. Accardo MC, Dimitri P: Fluorescence in situ hybridization with Bacterial Artificial Chromosomes (BACs) to mitotic heterochromatin of Drosophila. Methods Mol Biol; 2010;659:389-400
Hazardous Substances Data Bank. DIGOXIGENIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fluorescence in situ hybridization with Bacterial Artificial Chromosomes (BACs) to mitotic heterochromatin of Drosophila.
  • Fluorescence in situ hybridization (FISH) using Bacterial Artificial Chromosomes (BAC) probes that carry large genomic portions defined by sequence annotation has yielded a "revolution" in the field of cytogenetics because it has allowed the mapping of multiple genes at once, thus rendering constitutive heterochromatin amenable to easy and fast cytogenetics analyses.
  • Indeed, BAC-based FISH approaches on Drosophila mitotic chromosomes have made it possible to correlate genomic sequences to their cytogenetic location, aiming to build an integrated map of the pericentric heterochromatin.
  • This chapter presents our standard protocols for BAC-based FISH, aimed at mapping large chromosomal regions of mitotic heterochromatin in Drosophila melanogaster.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / metabolism. Drosophila melanogaster / cytology. Drosophila melanogaster / metabolism. Heterochromatin / metabolism. In Situ Hybridization, Fluorescence / methods. Mitosis
  • [MeSH-minor] Animals. Brain / cytology. Brain / metabolism. Chromosomes, Insect / metabolism. DNA, Bacterial / isolation & purification. DNA, Bacterial / metabolism. Digoxigenin / metabolism. Larva. Rhodamines / metabolism

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  • (PMID = 20809329.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Bacterial; 0 / Heterochromatin; 0 / Rhodamines; NQ1SX9LNAU / Digoxigenin
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88. Giel-Moloney M, Krause DS, Chen G, Van Etten RA, Leiter AB: Ubiquitous and uniform in vivo fluorescence in ROSA26-EGFP BAC transgenic mice. Genesis; 2007 Feb;45(2):83-9
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  • [Title] Ubiquitous and uniform in vivo fluorescence in ROSA26-EGFP BAC transgenic mice.
  • Transplantation studies and cell lineage analyses require the ability to explicitly distinguish morphologically identical cells that have an identifiable marker indicating their origin in vivo.
  • In this report, we describe the generation of transgenic mice that express enhanced green fluorescent protein (EGFP) under control of a 187 kb bacterial artificial chromosome (BAC) containing the murine ROSA26 locus, and show several advantages over existing EGFP reporter lines.
  • It is demonstrated that EGFP is ubiquitously and reproducibly expressed from the murine BAC transgene in all organs and tissues analyzed, including the hematolymphoid compartment.
  • Using this new reporter strain in hematopoietic cell transplantation studies, it is demonstrated that leukocytes in recipients maintain uniform transgene expression and are easily distinguished by flow cytometric analysis of live cells.
  • The results suggest that the ROSA26 BAC is an efficient strategy for expressing complex transgene cassettes in vivo.

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  • [Copyright] Published 2007 Wiley-Liss, Inc.
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  • (PMID = 17269129.001).
  • [ISSN] 1526-954X
  • [Journal-full-title] Genesis (New York, N.Y. : 2000)
  • [ISO-abbreviation] Genesis
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / T32-DK007542; United States / NCI NIH HHS / CA / CA090576-07; United States / NCI NIH HHS / CA / CA105043-03; United States / NIDDK NIH HHS / DK / P30 DK034928; United States / NIDDK NIH HHS / DK / DK67166; United States / NIDDK NIH HHS / DK / DK007542-20; United States / NIDDK NIH HHS / DK / T32 DK007542-21; United States / NCI NIH HHS / CA / CA90576; United States / NIDDK NIH HHS / DK / T32 DK007542-20; United States / NCI NIH HHS / CA / R01 CA090576-07; United States / NIDDK NIH HHS / DK / DK007542-21; United States / NCI NIH HHS / CA / R01 CA090576; United States / NIDDK NIH HHS / DK / DK067166-02; United States / NIDDK NIH HHS / DK / DK52870; United States / NIDDK NIH HHS / DK / R01 DK067166-02; United States / NIDDK NIH HHS / DK / DK034928-239002; United States / NCI NIH HHS / CA / R01 CA105043; United States / NIDDK NIH HHS / DK / P30-DK34928; United States / NIDDK NIH HHS / DK / DK43673; United States / NCI NIH HHS / CA / R01 CA105043-03; United States / NIDDK NIH HHS / DK / T32 DK007542; United States / NIDDK NIH HHS / DK / R01 DK067166; United States / NIDDK NIH HHS / DK / P30 DK034928-239002; United States / NIDDK NIH HHS / DK / R01 DK043673; United States / NCI NIH HHS / CA / CA105043
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gt(ROSA)26Sor non-coding RNA, mouse; 0 / Proteins; 0 / RNA, Untranslated; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins
  • [Other-IDs] NLM/ NIHMS26640; NLM/ PMC2121618
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89. Baig MN, Yu A, Guo W, Deng X: Construction and characterization of two Citrus BAC libraries and identification of clones containing the phytoene synthase gene. Genome; 2009 May;52(5):484-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Construction and characterization of two Citrus BAC libraries and identification of clones containing the phytoene synthase gene.
  • Two deep-coverage Bacterial Artificial Chromosome (BAC) libraries of Citrus sinensis (L.
  • The C. sinensis BAC library consists of 36 000 clones with negligible false-positive clones and an estimated average insert size of 126 kb covering ~4.5 x 109 bp and thus providing an 11.8-fold coverage of haploid genome equivalents, whereas the C. reticulata library consists of 21 000 clones also with negligible false-positive clones and an estimated average of 120 kb covering ~2.5 x 109 bp representing a 6.6-fold coverage of haploid genome equivalents.
  • Screening has been performed by Southern hybridization of BAC filters, which results in <0.5% chloroplast DNA contamination and no mitochondrial DNA contamination in both libraries.
  • Eight and five positive clones harboring the gene encoding Phytoene synthase (Psy (EC 2.5.1.32)) were identified from the C. sinensis and C. reticulata libraries, respectively, using the filter hybridization procedure.
  • These results suggest that the two BAC libraries are useful tools for the isolation of functional genes and advanced genomics research in the two important species C. sinensis and C. reticulata.

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  • (PMID = 19448728.001).
  • [ISSN] 0831-2796
  • [Journal-full-title] Genome
  • [ISO-abbreviation] Genome
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA, Mitochondrial; EC 2.5.- / Alkyl and Aryl Transferases; EC 2.5.1.32 / Geranylgeranyl-Diphosphate Geranylgeranyltransferase
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90. Islam-Faridi MN, Nelson CD, DiFazio SP, Gunter LE, Tuskan GA: Cytogenetic analysis of Populus trichocarpa--ribosomal DNA, telomere repeat sequence, and marker-selected BACs. Cytogenet Genome Res; 2009;125(1):74-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytogenetic analysis of Populus trichocarpa--ribosomal DNA, telomere repeat sequence, and marker-selected BACs.
  • Six BAC clones selected from 2 linkage groups based on genome sequence assembly (LG-I and LG-VI) were localized on 2 chromosomes, as expected.
  • BACs from LG-I hybridized to the longest chromosome in the complement.
  • All BAC positions were found to be concordant with sequence assembly positions.
  • BAC-FISH will be useful for delineating each of the Populus trichocarpa chromosomes and improving the sequence assembly of this model angiosperm tree species.
  • [MeSH-minor] Arabidopsis / genetics. Chromosomes, Artificial, Bacterial / genetics. Chromosomes, Plant / genetics. Cytogenetic Analysis. Genetic Markers. In Situ Hybridization, Fluorescence. Repetitive Sequences, Nucleic Acid. Species Specificity. Telomere / genetics

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19617699.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / DNA, Plant; 0 / DNA, Ribosomal; 0 / Genetic Markers
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91. Lin T, Yasumoto H, Tsai RY: BAC transgenic expression efficiency: bicistronic versus ATG-fusion strategies. Genesis; 2007 Oct;45(10):647-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BAC transgenic expression efficiency: bicistronic versus ATG-fusion strategies.
  • Bacterial artificial chromosome (BAC)-based transgene can be expressed bicistronically with the target gene or fused to its translation start codon.
  • This work provides important information for designing BAC transgenics when the transgene expression level is crucial.

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
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  • (PMID = 17941047.001).
  • [ISSN] 1526-954X
  • [Journal-full-title] Genesis (New York, N.Y. : 2000)
  • [ISO-abbreviation] Genesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA113750-02; United States / NCI NIH HHS / CA / R01 CA113750; United States / NCI NIH HHS / CA / CA113750; United States / NCI NIH HHS / CA / R01 CA113750-02
  • [Publication-type] Comparative Study; Letter; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / Codon, Initiator; 0 / Nuclear Proteins; 0 / Recombinant Fusion Proteins; 0 / nucleostemin protein, mouse; 147336-22-9 / Green Fluorescent Proteins
  • [Other-IDs] NLM/ NIHMS211485; NLM/ PMC2966870
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92. Berr A, Schubert I: Direct labelling of BAC-DNA by rolling-circle amplification. Plant J; 2006 Mar;45(5):857-62
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Direct labelling of BAC-DNA by rolling-circle amplification.
  • Here we demonstrate successful rolling-circle amplification (RCA) of very low amounts of long circular template sequences (single bacterial artificial chromosomes (BACs) or pools of BACs).
  • A novel achievement is the use of RCA for simultaneous amplification and labelling of single BACs or BAC pools in a labour- and cost-effective manner.
  • [MeSH-minor] Arabidopsis / genetics. Chromosomes, Artificial, Bacterial. DNA Probes / chemical synthesis


93. Valjent E, Bertran-Gonzalez J, Hervé D, Fisone G, Girault JA: Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice. Trends Neurosci; 2009 Oct;32(10):538-47

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Looking BAC at striatal signaling: cell-specific analysis in new transgenic mice.
  • The recent development of bacterial artificial chromosome (BAC) transgenic mice expressing a variety of reporters, epitope tagged-proteins or Cre recombinase driven by specific promoters, is a significant step forward in this direction.
  • Thus, BAC transgenic mice are changing the way to conceive experiments and provide an opportunity to fill the gaps between molecular and systems neurosciences.
  • [MeSH-major] Chromosomes, Artificial, Bacterial / genetics. Corpus Striatum / metabolism. Mice, Transgenic. Neurons / metabolism. Signal Transduction / genetics

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  • (PMID = 19765834.001).
  • [ISSN] 1878-108X
  • [Journal-full-title] Trends in neurosciences
  • [ISO-abbreviation] Trends Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dopamine Agents; 0 / Dopamine and cAMP-Regulated Phosphoprotein 32; 0 / Receptors, Dopamine D1; 0 / Receptors, Dopamine D2; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  • [Number-of-references] 80
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94. Madrigal I, Carrió A, Gómez C, Rozman M, Esteve J, Nomdedeu B, Campo E, Costa D: Fluorescence in situ hybridization studies using BAC clones of the EVI1 locus in hematological malignancies with 3q rearrangements. Cancer Genet Cytogenet; 2006 Oct 15;170(2):115-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fluorescence in situ hybridization studies using BAC clones of the EVI1 locus in hematological malignancies with 3q rearrangements.
  • Chromosomal rearrangements involving 3q26 are a recurrent aberration in malignant myeloid disorders.
  • Fluorescence in situ hybridization (FISH) studies using bacterial artificial chromosome (BAC) clones were conducted to determine whether the EVI1 locus was rearranged in nine patients with hematological malignancies carrying 3q abnormalities.
  • A dual-color probe was constructed with nine BACs; centromeric clones covering 1 Mb and including the EVI1 gene were labeled with a red fluorescent dye and telomeric clones covering 1 Mb were labeled with a green fluorescent dye.
  • FISH analysis with BAC clones was a useful tool for identifying the chromosome breakpoints affecting the EVI1 locus in patients with 3q26 rearrangements.
  • [MeSH-minor] Chromosomes, Artificial, Bacterial. Gene Duplication. Humans. Translocation, Genetic

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  • (PMID = 17011981.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / MECOM protein, human; 0 / Transcription Factors
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95. Basu J, Stromberg G, Compitello G, Willard HF, Van Bokkelen G: Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays. Nucleic Acids Res; 2005;33(2):587-96
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid creation of BAC-based human artificial chromosome vectors by transposition with synthetic alpha-satellite arrays.
  • Efficient construction of BAC-based human artificial chromosomes (HACs) requires optimization of each key functional unit as well as development of techniques for the rapid and reliable manipulation of high-molecular weight BAC vectors.
  • Using these vectors, we show that the presence of CENP-B box elements is a requirement for efficient de novo centromere formation and that increasing the density of CENP-B box elements may enhance the efficiency of de novo centromere formation.
  • Furthermore, we have developed a novel, high-throughput methodology that permits the rapid conversion of any genomic BAC target into a HAC vector by transposon-mediated modification with synthetic alpha-satellite arrays and other key functional units.
  • Taken together, these approaches offer the potential to significantly advance the utility of BAC-based HACs for functional annotation of the genome and for applications in gene transfer.
  • [MeSH-major] Centromere / genetics. Chromosomes, Artificial, Bacterial. Chromosomes, Artificial, Human. DNA, Satellite / genetics. Gene Transfer Techniques
  • [MeSH-minor] Autoantigens / metabolism. Base Sequence. Binding Sites. Cell Line. Centromere Protein B. Chromosomal Proteins, Non-Histone / metabolism. DNA Transposable Elements. DNA-Binding Proteins / metabolism. Genetic Engineering. Genomics / methods. Humans

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  • (PMID = 15673719.001).
  • [ISSN] 1362-4962
  • [Journal-full-title] Nucleic acids research
  • [ISO-abbreviation] Nucleic Acids Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantigens; 0 / CENPB protein, human; 0 / Centromere Protein B; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA Transposable Elements; 0 / DNA, Satellite; 0 / DNA-Binding Proteins
  • [Other-IDs] NLM/ PMC548352
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96. Adam-Blondon AF, Bernole A, Faes G, Lamoureux D, Pateyron S, Grando MS, Caboche M, Velasco R, Chalhoub B: Construction and characterization of BAC libraries from major grapevine cultivars. Theor Appl Genet; 2005 May;110(8):1363-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Construction and characterization of BAC libraries from major grapevine cultivars.
  • Genome projects were initiated on grapevine (Vitis vinifera L., 2n=38, genome size 475 Mb) through the successful construction of four bacterial artificial chromosome (BAC) libraries from three major cultivars, Cabernet Sauvignon (Cabernet S), Syrah and two different clones of Pinot Noir (Pinot N).
  • BAC pools suitable for PCR screening were constructed for two of these BAC libraries [Cabernet S and Pinot N clone (cl) 115] and subsequently used to confirm the genome coverage of both libraries by PCR anchoring of 74 genetic markers sampled from the 19 linkage groups.
  • For ten of these markers, two bands on separate BAC pools were differentiated that could correspond either to different alleles or to a duplication of the locus being studied.
  • A pair of markers, 2.1 cM apart, anchored the same BAC clones, which allowed us to estimate that 1 cM corresponded in this particular region to a maximum length of 130 kb.
  • [MeSH-major] Chromosome Mapping. Chromosomes, Artificial, Bacterial. Gene Library. Genome, Plant. Vitis / genetics

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  • (PMID = 15834699.001).
  • [ISSN] 0040-5752
  • [Journal-full-title] TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
  • [ISO-abbreviation] Theor. Appl. Genet.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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97. Zhang Z, Huang Y, Zhu H: An efficient protocol for VZV BAC-based mutagenesis. Methods Mol Biol; 2010;634:75-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An efficient protocol for VZV BAC-based mutagenesis.
  • Recently, an efficient protocol has been developed based on a luciferase-containing VZV bacteria artificial chromosome (BAC) system to rapidly isolate and study VZV ORF deletion mutants.
  • [MeSH-major] Chromosomes, Artificial, Bacterial. Herpesvirus 3, Human / genetics. Mutagenesis
  • [MeSH-minor] Cell Line. Electroporation. Humans. Open Reading Frames. Recombination, Genetic

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  • (PMID = 20676976.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Voas RB, Romano E, Peck R: Validity of the passive alcohol sensor for estimating BACs in DWI-enforcement operations. J Stud Alcohol; 2006 Sep;67(5):714-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Validity of the passive alcohol sensor for estimating BACs in DWI-enforcement operations.
  • The objective of this study was to determine the accuracy of the PAS unit for estimating the blood alcohol concentration (BAC) of drivers and study its potential use as a screening device for estimating BAC in relation to several factors related to its use (age, gender, light conditions, and police confidence in the PAS measure).
  • METHOD: A recent study funded by the National Highway Traffic Safety Administration of the BAC levels of crash-involved and randomly stopped drivers as a control group for comparison provided 12,587 cases in which both a breath test and a PAS measure of BAC were obtained for each driver studied.
  • RESULTS: PAS scores were a strong predictor of a driver's BAC status.
  • [MeSH-major] Alcoholic Intoxication / diagnosis. Alcoholic Intoxication / epidemiology. Automobile Driving / statistics & numerical data. Law Enforcement. Police. Substance Abuse Detection / methods

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  • (PMID = 16847540.001).
  • [ISSN] 0096-882X
  • [Journal-full-title] Journal of studies on alcohol
  • [ISO-abbreviation] J. Stud. Alcohol
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / K05 AA014260; United States / NIAAA NIH HHS / AA / R21 AA015093
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Validation Studies
  • [Publication-country] United States
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99. Knijnenburg J, van der Burg M, Nilsson P, Ploos van Amstel HK, Tanke H, Szuhai K: Rapid detection of genomic imbalances using micro-arrays consisting of pooled BACs covering all human chromosome arms. Nucleic Acids Res; 2005;33(18):e159
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rapid detection of genomic imbalances using micro-arrays consisting of pooled BACs covering all human chromosome arms.
  • A strategy is presented to select, pool and spot human BAC clones on an array in such a way that each spot contains five well performing BAC clones, covering one chromosome arm.
  • A mini-array of 240 spots was prepared representing all human chromosome arms in a 5-fold as well as some controls, and used for comparative genomic hybridization (CGH) of 10 cell lines with aneusomies frequently found in clinical cytogenetics and oncology.
  • Sensitivity was such that replacing one BAC clone in a given spot of five by a BAC clone from another chromosome, thus resulting in a change in ratio of 20%, was reproducibly detected.
  • Potential application of these mini-arrays for genomic profiling of disseminated tumour cells or of blastomeres for preimplantation genetic diagnosis, using specially designed DNA amplification methods, are discussed.
  • [MeSH-major] Aneuploidy. Chromosomes, Artificial, Bacterial. Chromosomes, Human. Genomics / methods. Oligonucleotide Array Sequence Analysis / methods
  • [MeSH-minor] Cell Line. Female. Humans. Male. Time Factors

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  • (PMID = 16221972.001).
  • [ISSN] 1362-4962
  • [Journal-full-title] Nucleic acids research
  • [ISO-abbreviation] Nucleic Acids Res.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1253841
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100. Miyake N, Shimokawa O, Harada N, Sosonkina N, Okubo A, Kawara H, Okamoto N, Kurosawa K, Kawame H, Iwakoshi M, Kosho T, Fukushima Y, Makita Y, Yokoyama Y, Yamagata T, Kato M, Hiraki Y, Nomura M, Yoshiura K, Kishino T, Ohta T, Mizuguchi T, Niikawa N, Matsumoto N: BAC array CGH reveals genomic aberrations in idiopathic mental retardation. Am J Med Genet A; 2006 Feb 1;140(3):205-11
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BAC array CGH reveals genomic aberrations in idiopathic mental retardation.
  • Array using 2,173 BAC clones covering the whole human genome has been constructed.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Artificial, Bacterial / genetics. Genome, Human. Intellectual Disability / genetics. Nucleic Acid Hybridization / methods

  • Genetic Alliance. consumer health - Mental Retardation.
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  • [Copyright] 2006 Wiley-Liss, Inc.
  • (PMID = 16419101.001).
  • [ISSN] 1552-4825
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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