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6. Tang XW, Huang HY, Zhan SH, Sun XW, Shi XL, Sun AN, Shen ZY, Kang SY, Jin ZM, Qiu HY, Miao M, Fu ZZ, Han Y, Chen SN, Xue SL, Ma X, Liu YJ, Hu XH, Zhou HF, Wu DP: [Surgical treatment and pathological findings of hematological malignancies patients complicated with lung diseases.]. Zhonghua Xue Ye Xue Za Zhi; 2009 Dec;30(12):829-33
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  • [Title] [Surgical treatment and pathological findings of hematological malignancies patients complicated with lung diseases.].
  • RESULTS: Pathological examination confirmed: aspergillus infection in 9 patients, sub-acute inflammation (fibrosis and hematoma formation) in 3, and each in 1 of pulmonary infarction with granulomatous tissue in the periphery; granulomatous inflammation with calcified tubercle; alveolar dilation and hemorrhage, interstitial fibrosis and focal vasculitis; intercostal neurilemmoma; and moderate-differentiated adenocarcinoma accompanied by intrapulmonary metastasis.
  • The coincidence rate of pre- and post-operative diagnosis was 9/14 (64.3%).
  • CONCLUSION: Hematological malignancies with persistent and/or resistant pulmonary infection, hemoptysis, or unexplained lung diseases, should be treated in time by surgery operation to effectively eliminate residual disease and obtain a definitive diagnosis, so as to create a prerequisite condition for the following treatments.
  • [MeSH-minor] Aspergillosis / diagnosis. Hematopoietic Stem Cell Transplantation. Humans. Lung Diseases

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  • (PMID = 20193605.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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7. Saad RS, Liu YL, Silverman JF: Distribution of basal/myoepithelial markers in benign and malignant bronchioloalveolar proliferations of the lung. Appl Immunohistochem Mol Morphol; 2010 May;18(3):219-25
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  • [Title] Distribution of basal/myoepithelial markers in benign and malignant bronchioloalveolar proliferations of the lung.
  • We investigated the staining pattern of commonly used basal cell/myoepithelial markers, such as p63 (a p53-homologous nuclear protein), basal cell-specific cytokeratin antibody (34betaE12, K903), and smooth muscle myosin heavy chain (SMMHC) in benign and malignant bronchioloalveolar proliferations of the lung.
  • We studied 85 lung lesions consisting of 35 bronchioloalveolar carcinoma, 30 well-differentiated adenocarcinoma, and 20 cases of benign lung lesions.
  • In normal lung, p63, K903, and SMMHC decorated the basal cells of large and small airways and occasional cells of terminal bronchioles.
  • Respiratory ciliated cells, alveolar epithelial cells, and nonepithelial cells were negative.
  • For adenocarcinoma, a majority of the cases (28/30, 93%) were negative for p63 and K903; however, SMMHC showed artifactual staining in the desmoplastic stroma in 6/30 (20%) cases.

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  • (PMID = 20065853.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 68238-35-7 / Keratins; EC 3.6.1.- / Smooth Muscle Myosins
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8. Altorki NK, Yankelevitz DF, Vazquez MF, Kramer A, Henschke CI: Bronchioloalveolar carcinoma in small pulmonary nodules: clinical relevance. Semin Thorac Cardiovasc Surg; 2005;17(2):123-7
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  • The diagnosis of malignancy in this setting can be challenging to radiologists, surgeons, and occasionally pathologists as well.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / pathology. Solitary Pulmonary Nodule / pathology

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  • (PMID = 16087079.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Park JH, Lee KS, Kim JH, Shim YM, Kim J, Choi YS, Yi CA: Malignant pure pulmonary ground-glass opacity nodules: prognostic implications. Korean J Radiol; 2009 Jan-Feb;10(1):12-20
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  • Differences in patient prognoses were compared for nodule number, size, surgical method, change in size before surgical removal, and histopathological diagnosis by use of Fisher's exact test and Pearson's chi-squared test.
  • RESULTS: Of the 58 patients, 40 patients (69%) were confirmed to have a bronchioloalveolar carcinoma (BAC) and 18 patients (31%) were confirmed to have an adenocarcinoma with a predominant BAC component.
  • Irrespective of nodule size, number, treatment method, change in size before surgical removal and histopathological diagnosis, neither local recurrence nor a metastasis occurred in any of these patients as determined at a follow-up period of 24 months (range; 12-65 months).
  • CONCLUSION: Prognoses in patients with pure GGO malignant pulmonary nodules are excellent, and not significantly different in terms of nodule number, size, surgical method, presence of size change before surgical removal and histopathological diagnosis.
  • [MeSH-major] Lung Neoplasms / radiography. Multiple Pulmonary Nodules / radiography. Solitary Pulmonary Nodule / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Female. Humans. Male. Middle Aged. Prognosis. Young Adult

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  • (PMID = 19182498.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2647178
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10. Popescu I: [Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention]. Pneumologia; 2008 Oct-Dec;57(4):201-8
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  • [Title] [Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention].
  • Early diagnosis of pulmonary cancer is crucial in the fight against this disease.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Antineoplastic Agents / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Precancerous Conditions / drug therapy. Precancerous Conditions / pathology
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bevacizumab. Biomarkers, Tumor / metabolism. Bronchoalveolar Lavage. Bronchoscopy / methods. Cetuximab. Early Diagnosis. Erlotinib Hydrochloride. Genes, p16. Humans. Mass Screening. Mutation. Positron-Emission Tomography. Predictive Value of Tests. Quinazolines / administration & dosage. Sensitivity and Specificity. Tomography, Optical Coherence. Treatment Outcome. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19186682.001).
  • [ISSN] 2067-2993
  • [Journal-full-title] Pneumologia (Bucharest, Romania)
  • [ISO-abbreviation] Pneumologia
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Quinazolines; 0 / Tumor Suppressor Protein p53; 2S9ZZM9Q9V / Bevacizumab; DA87705X9K / Erlotinib Hydrochloride; PQX0D8J21J / Cetuximab; S65743JHBS / gefitinib
  • [Number-of-references] 48
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11. Kitada M, Ozawa K, Sato K, Hayashi S, Miyokawa N, Sasajima T: Clear cell carcinoma of the lung. Gen Thorac Cardiovasc Surg; 2010 Feb;58(2):87-90
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  • [Title] Clear cell carcinoma of the lung.
  • We present here in the case of a patient who underwent resection of clear cell carcinoma of the lung, a rare histological type.
  • A screening test of the 71-year-old woman revealed a 2.0-cm lesion in S4 of the right lung with a diagnosis of bronchioloalveolar carcinoma before resection.
  • The histopathological examination showed clear, slightly acidophilic tumor cells rich in fine granular components proliferating in an alveolar fashion.
  • Immunostaining was diagnostically useful, distinguishing clear cell carcinoma from lung metastasis of renal clear cell carcinoma or clear cell squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Aged. Biopsy. Cell Differentiation. Cell Proliferation. Diagnostic Errors. Female. Humans. Immunohistochemistry. Lymph Node Excision. Neoplasm Staging. Predictive Value of Tests. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20155345.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Uji M, Matsushita H, Watanabe T, Suzumura T: [A case of primary Sjögren's syndrome complicated with lung adenocarcinoma]. Nihon Kokyuki Gakkai Zasshi; 2007 May;45(5):409-12
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  • [Title] [A case of primary Sjögren's syndrome complicated with lung adenocarcinoma].
  • The serum value of carcinoembryonic antigen was highly elevated, so we made a presumed diagnosis of primary non-small lung cancer.
  • The elevated values of serum antibodies against SS-A and SS-B and further examinations resulted in a definitive diagnosis of primary Sjögren's syndrome.
  • Autopsy revealed that the mass shadow was a primary lung adenocarcinoma.
  • Those lesions had bullae, emphysema, and alveolar septae thickened by infiltration of lymphoplasmacytic cells.
  • We raise a possibility that lung cancer might derive from cystic lesions associated with Sjögren's syndrome.
  • [MeSH-major] Adenocarcinoma / complications. Lung Neoplasms / complications. Sjogren's Syndrome / complications

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  • (PMID = 17554985.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Nakamura N, Kobayashi K, Nakamoto M, Kohno T, Sasaki H, Matsuno Y, Yokota J: Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma. Oncogene; 2006 Jul 13;25(30):4245-55
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  • [Title] Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma.
  • To identify tumor markers and differentiation markers for lung adenocarcinoma (AdC), we analysed expression profiles of 14,500 genes against three cases of type II alveolar epithelial cells, bronchiolar epithelial cells, and bronchial epithelial cells, respectively, and 10 cases of AdC cells isolated by laser capture microdissection.
  • Hierarchical clustering analysis indicated that AdC cells and noncancerous lung epithelial cells are significantly different in their expression profiles, and that different sets of differentiation markers are expressed among alveolar, bronchiolar and bronchial epithelial cells.
  • Nine genes were identified as being highly expressed in AdC cells, but not expressed in noncancerous lung epithelial cells.
  • Sixteen genes were identified as differentiation markers for lung epithelial cells.
  • Real-time RT-PCR analysis of 45 lung AdC cases further revealed that expression of four tumor markers in AdC cells was significantly higher than that in noncancerous lung cells and that expression of ten differentiation markers was retained in a considerable fraction of lung AdC cases.
  • Similarities and differences in expression profiles between normal epithelial cells from different lung respiratory compartments and AdC cells demonstrated in this study will be informative for the molecular diagnosis of lung AdC.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Biomarkers, Tumor. Cell Differentiation. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 16491115.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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4. Kim TH, Kim SJ, Ryu YH, Chung SY, Seo JS, Kim YJ, Choi BW, Lee SH, Cho SH: Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia. Eur Radiol; 2006 Aug;16(8):1763-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to evaluate retrospectively the differential CT features of bronchioloalveolar carcinoma (BAC) mimicking pneumonia and infectious pneumonia at the lung periphery.
  • CT images were reviewed in 47 patients with focal areas of parenchymal opacification at the lung periphery.
  • We evaluated the presence of ground-glass attenuation, marginal conspicuity of the lesion, CT angiogram sign, air-bronchogram sign, a bubble-like low-attenuation area within the lesion, presence of pleural thickening and retraction associated with the lesion, presence of pleural effusion and extra-pleural fatty hypertrophy, presence of bronchial wall thickening proximal to the lesion, and air-trapping in the normal lung near the lesion.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnostic imaging. Lung Neoplasms / diagnostic imaging. Pneumonia / diagnostic imaging. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Radiography, Thoracic. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16418864.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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15. Ohtsuka T, Watanabe K, Kaji M, Naruke T, Suemasu K: A clinicopathological study of resected pulmonary nodules with focal pure ground-glass opacity. Eur J Cardiothorac Surg; 2006 Jul;30(1):160-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: The histological diagnosis was bronchioloalveolar carcinoma (BAC) in 10 patients (12 lesions), atypical adenomatous hyperplasia (AAH) in 15 patients (22 lesions), and focal scar in 1 patient (1 lesion).
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenomatosis, Pulmonary / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoembryonic Antigen / blood. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Palpation. Tomography, X-Ray Computed

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  • (PMID = 16723239.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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16. Niang A, Bonnichon A, Ba-Fall K, Dussart C, Camara P, Vaylet F, Mbaye PS, L'Her P, Sane M, Margery J: [Lung cancer in Senegal]. Med Trop (Mars); 2007 Dec;67(6):651-6
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  • [Title] [Lung cancer in Senegal].
  • In Africa the incidence of lung cancer is rising rapidly.
  • The purpose of this prospective study was to analyze clinical, therapeutic, and prognostic features of lung cancer patients treated at the Principal Hospital in Dakar between 2002 and 2007.
  • The histological diagnosis was squamous cell carcinoma in 23 cases, adenocarcinoma in 14, large-cell carcinoma in 17, small-cell lung cancer in 2, and bronchiolo-alveolar cancer in 1.
  • The much higher rate of histological diagnosis than in the sub-region is due mainly to the availability of trained personnel with access to bronchial endoscopy and CT-scan needle biopsy since September 2003.
  • Lung cancer is a health issue in Dakar, Senegal.
  • [MeSH-major] Carcinoma / epidemiology. Carcinoma / therapy. Lung Neoplasms / epidemiology. Lung Neoplasms / therapy

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  • (PMID = 18300532.001).
  • [ISSN] 0025-682X
  • [Journal-full-title] Médecine tropicale : revue du Corps de santé colonial
  • [ISO-abbreviation] Med Trop (Mars)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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17. Reyes Ojeda MD, López Aznar DJ, Abreu Sánchez P, Uruburu Garcia E, Martínez Carsi C, Sopena Monforte R: [Bronchioloalveolar carcinoma as potencial cause of false negative with PET-FDG]. Rev Esp Med Nucl; 2005 Jul-Aug;24(4):254
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radionuclide imaging. Adenocarcinoma, Mucinous / radionuclide imaging. Fluorodeoxyglucose F18. Lung Neoplasms / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals
  • [MeSH-minor] Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / secondary. Diagnosis, Differential. Humans. Male. Middle Aged. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16122411.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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18. Allen TC, Moran C: Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. Arch Pathol Lab Med; 2006 May;130(5):721-4
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  • The patients underwent surgery for treatment of adenocarcinoma that was diagnosed preoperatively.
  • Diffuse malignant mesothelioma was suspected on the basis of pleural involvement by tumor with histology differing from that of the adenocarcinoma.
  • The average survival after diagnosis was 6 weeks or less.
  • Length of survival following diagnosis is bleak.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / pathology. Mesothelioma / pathology. Neoplasms, Multiple Primary. Pleural Neoplasms / pathology

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  • (PMID = 16683892.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Kang MJ, Kim MA, Park CM, Lee CH, Goo JM, Lee HJ: Ground-glass nodules found in two patients with malignant melanomas: different growth rate and different histology. Clin Imaging; 2010 Sep-Oct;34(5):396-9
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  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Melanoma / diagnosis. Skin Neoplasms / pathology. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Lung / radiography. Lung / surgery. Male. Middle Aged


20. Collins AM, Ridgway PF, Killeen RP, Dodd JD, Tolan M: Congenital cystic adenomatoid malformation of the lung: hazards of delayed diagnosis. Respirology; 2009 Sep;14(7):1058-60
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  • [Title] Congenital cystic adenomatoid malformation of the lung: hazards of delayed diagnosis.
  • Lung-sparing surgery, in the form of two segmentectomies and a non-anatomical resection, was performed in order to avoid pneumonectomy.
  • [MeSH-major] Cystic Adenomatoid Malformation of Lung, Congenital / complications. Cystic Adenomatoid Malformation of Lung, Congenital / diagnosis. Delayed Diagnosis
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / etiology. Adult. Humans. Lung / abnormalities. Lung / pathology. Lung / radiography. Lung Neoplasms / etiology. Male. Tomography, X-Ray Computed

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  • (PMID = 19740267.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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61. Liu S, Cheng H, Yao S, Wang C, Han G, Li X, Liu C: The clinical application value of PET/CT in adenocarcinoma with bronchioloalveolar carcinoma features. Ann Nucl Med; 2010 Aug;24(7):541-7
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  • [Title] The clinical application value of PET/CT in adenocarcinoma with bronchioloalveolar carcinoma features.
  • OBJECTIVE: The goal of our study was to demonstrate the clinical usefulness of positron emission tomography/computed tomography (PET/CT) for adenocarcinoma with bronchioloalveolar carcinoma (BAC) features, through evaluating the relationship between the intrathoracic lymph node metastases and maximum standardized uptake value (SUVmax), tumor size of the primary tumor and the ratio of BAC component and analysing the correlation of SUVmax, tumor size and the ratio of BAC component.
  • Forty-five patients with focal peripheral lung adenocarcinoma with BAC features were included in this study and underwent the PET/CT scan.
  • The diagnosis of the lesion was made by surgical histopathology.
  • CONCLUSIONS: PET/CT would be clinically useful for adenocarcinoma with BAC features, because SUVmax obtained by PET/CT can predict the incidence of intrathoracic lymph node metastases at preoperative stages and even for inoperable patients.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / complications. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20614257.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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62. Xu X, Chung JH, Jheon S, Sung SW, Lee CT, Lee JH, Choe G: The accuracy of frozen section diagnosis of pulmonary nodules: evaluation of inflation method during intraoperative pathology consultation with cryosection. J Thorac Oncol; 2010 Jan;5(1):39-44
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  • [Title] The accuracy of frozen section diagnosis of pulmonary nodules: evaluation of inflation method during intraoperative pathology consultation with cryosection.
  • INTRODUCTION: Intraoperative frozen section diagnosis (FSD) is a very important pathologic examination that can determine the extent of the subsequent surgical procedure.
  • The frozen section quality of lung tissue was excellent after inflation with diluted embedding medium.
  • Inflated lung specimens harboring minute lesion displayed distinct gross appearance, which could not be palpated.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Frozen Sections / methods. Hyperplasia / diagnosis. Lung Neoplasms / diagnosis. Precancerous Conditions / diagnosis. Solitary Pulmonary Nodule / diagnosis

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  • (PMID = 19934776.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Hautmann H, Henke MO, Bitterling H: High diagnostic yield from transbronchial biopsy of solitary pulmonary nodules using low-dose CT-guidance. Respirology; 2010 May;15(4):677-82
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  • [MeSH-major] Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Aged. Bronchoscopy / methods. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Cohort Studies. Female. Fluoroscopy. Humans. Male. Middle Aged. Radiation Dosage. Small Cell Lung Carcinoma / diagnosis. Small Cell Lung Carcinoma / pathology

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  • (PMID = 20409025.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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64. De Filippo M, Onniboni M, Rusca M, Carbognani P, Ferrari L, Guazzi A, Casalini A, Verardo E, Cataldi V, Tiseo M, Sverzellati N, Chiari G, Rabaiotti E, Corsi A, Cacciani G, Sommario M, Ardizzoni A, Zompatori M: Advantages of multidetector-row CT with multiplanar reformation in guiding percutaneous lung biopsies. Radiol Med; 2008 Oct;113(7):945-53
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  • [Title] Advantages of multidetector-row CT with multiplanar reformation in guiding percutaneous lung biopsies.
  • PURPOSE: This study aimed to assess the usefulness of multiplanar reformations (MPR) during multidetector-row computed tomography (MDCT)-guided percutaneous needle biopsy of lung lesions difficult to access with the guidance of the native axial images alone owing to overlying bony structures, large vessels or pleural fissures.
  • MATERIALS AND METHODS: MDCT-guided transthoracic needle biopsy (TNB) was performed on 84 patients (55 men and 29 women; mean age 65 years) with suspected lung neoplasm by using a spiral MDCT scanner with the simultaneous acquisition of six slices per rotation.
  • We took care to ensure the shortest needle path without overlying large vessels, main bronchi, pleural fissures or bony structures; access to the lung parenchyma as perpendicular as possible to the pleural plane; and sampling of highly attenuating areas of noncalcified tissue within the lesion.
  • [MeSH-major] Biopsy, Needle / methods. Image Processing, Computer-Assisted. Lung / pathology. Lung Neoplasms / diagnostic imaging. Lung Neoplasms / pathology. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / diagnostic imaging. Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / diagnostic imaging. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Aged. Carcinoid Tumor / diagnosis. Carcinoid Tumor / diagnostic imaging. Carcinoid Tumor / pathology. Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / diagnostic imaging. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / diagnostic imaging. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / diagnostic imaging. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Lymphoma / diagnosis. Lymphoma / diagnostic imaging. Lymphoma / pathology. Lymphomatoid Granulomatosis / diagnosis. Lymphomatoid Granulomatosis / diagnostic imaging. Lymphomatoid Granulomatosis / pathology. Male. Mesothelioma / diagnosis. Mesothelioma / diagnostic imaging. Mesothelioma / pathology. Middle Aged. Needles

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  • (PMID = 18818985.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
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65. Blons H, Côté JF, Le Corre D, Riquet M, Fabre-Guilevin E, Laurent-Puig P, Danel C: Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation. Am J Surg Pathol; 2006 Oct;30(10):1309-15
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  • [Title] Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation.
  • In lung cancer, an association was made between drastic clinical response to epidermal growth factor receptor (EGFR) inhibitors and the presence of somatic mutations within the tyrosine kinase domain of the EGFR.
  • To go further in the characterization of the EGF pathway, we screened EGFR, ERBB2, ERBB3, KRAS, BRAF, and PIK3CA for mutations in 2 groups of White patients with nonsmall cell lung cancer (45 cancers from women and 46 cancers from men).
  • We demonstrated that EGFR mutations were linked to female sex, absence of smoking, late age at diagnosis, and adenocarcinoma (ADC) with bronchioloalveolar (BAC) features.
  • Moreover, in invasive ADC with BAC component, microdissection assays showed that mutations were retrieved in both tumor subtypes suggesting that EGFR mutations appear early in lung carcinogenesis.
  • On the contrary, KRAS mutations correlated with smoking, younger age at diagnosis, and ADC subtype regardless of BAC differentiation.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / genetics. Carcinoma, Non-Small-Cell Lung / genetics. Lung Neoplasms / genetics. Mutation. Receptor, Epidermal Growth Factor / genetics


66. Damhuis RA, Schütte PR, Varin OC, van den Berg PM, Heinhuis R, Plaisier PW: Poor results after surgery for bronchioloalveolar carcinoma. Eur J Surg Oncol; 2006 Jun;32(5):573-6
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  • BACKGROUND: Bronchioloalveolar carcinoma (BAC) is suggested to be less aggressive than other types of lung cancer.
  • To assess the option of treatment modification, actual outcome data were studied and compared with results for other types of lung cancer.
  • METHOD: Retrospective analysis of all consecutive patients who underwent resection for stage I lung cancer in our hospital.
  • For 18 BAC cases, histological specimens were re-evaluated and in three cases diagnosis was revised.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adult. Age Factors. Aged. Carcinoma, Large Cell / surgery. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Pneumonectomy / classification. Postoperative Complications. Retrospective Studies. Sex Factors. Survival Rate. Treatment Outcome

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  • (PMID = 16580808.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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67. Wu M, Orta L, Gil J, Li G, Hu A, Burstein DE: Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma. Mod Pathol; 2008 May;21(5):553-8
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  • [Title] Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma.
  • The critical distinction of bronchioloalveolar carcinoma (BAC), well-differentiated adenocarcinoma (WDAC) of lung, adenomatous hyperplasia (AH) and atypical adenomatous hyperplasia (AAH), is based on morphological criteria alone, and is therefore potentially subjective.
  • Neither XIAP nor p63 were detected in normal lung alveolar cells.
  • In contrast, diffuse p63 staining may facilitate the identification of rare cases that may have been misclassified as alveolar in origin based on morphology but may be of BRC origin.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Membrane Proteins / biosynthesis. Precancerous Conditions / diagnosis. X-Linked Inhibitor of Apoptosis Protein / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Hyperplasia / pathology. Immunohistochemistry. Lung / pathology

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  • (PMID = 18432259.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / X-Linked Inhibitor of Apoptosis Protein; 0 / XIAP protein, human
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68. Asher Prince HM, Hatter JE: Case of the month. Concurrent diagnosis of lung cancer and tuberculosis. JAAPA; 2005 Feb;18(2):68
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  • [Title] Case of the month. Concurrent diagnosis of lung cancer and tuberculosis.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / complications. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / complications. Lung Neoplasms / diagnosis. Tuberculosis, Pulmonary / complications. Tuberculosis, Pulmonary / diagnosis

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  • (PMID = 15742785.001).
  • [ISSN] 1547-1896
  • [Journal-full-title] JAAPA : official journal of the American Academy of Physician Assistants
  • [ISO-abbreviation] JAAPA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Awab A, Hamadani M, Peyton M, Brown B: False-negative PET scan with bronchioloalveolar carcinoma: an important diagnostic caveat. Am J Med Sci; 2007 Oct;334(4):311-3
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  • Positron emission tomography (PET) is becoming widely accepted as a powerful diagnostic tool for the diagnosis of lung cancer, but it has very poor sensitivity for the detection of bronchioloalveolar carcinoma (BAC) and adenocarcinoma with BAC pattern, the less common form of pulmonary neoplasia.
  • PET has a reported sensitivity of over 98% in most series but misses almost two-thirds of BAC lesions, which might delay invasive testing and early diagnosis of this potentially lethal cancer.
  • Although this diagnostic limitation has been well reported in the radiology literature, the high reported sensitivity and sensitivity can give clinicians a false sense of security with negative PET scans of lung nodules.
  • The usual risk factors for bronchogenic carcinoma are less reliable for these subtypes of non-small-cell lung cancer; thus, clinicians need to have a high index of suspicion for BAC and exercise caution when making decisions on the basis of PET.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radionuclide imaging. Lung Neoplasms / radionuclide imaging

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  • (PMID = 18030191.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Hsu WH, Huang CS, Hsu HS, Huang WJ, Lee HC, Huang BS, Huang MH: Preoperative serum carcinoembryonic antigen level is a prognostic factor in women with early non-small-cell lung cancer. Ann Thorac Surg; 2007 Feb;83(2):419-24
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  • [Title] Preoperative serum carcinoembryonic antigen level is a prognostic factor in women with early non-small-cell lung cancer.
  • BACKGROUND: Carcinoembryonic antigen (CEA) is one of the markers evaluated in patients with non-small cell lung cancer (NSCLC).
  • Diagnosis of adenocarcinoma and bronchoalveolar carcinoma accounted for 83.4% of these 163 female patients.
  • [MeSH-major] Carcinoembryonic Antigen / blood. Carcinoma, Non-Small-Cell Lung / blood. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / blood. Lung Neoplasms / surgery. Preoperative Care. Pulmonary Surgical Procedures
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / blood. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Age Factors. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Staging. Pleura / pathology. Prognosis. Retrospective Studies

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  • [CommentIn] Ann Thorac Surg. 2007 Feb;83(2):424 [17257964.001]
  • (PMID = 17257963.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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71. Zell JA, Ou SH, Ziogas A, Anton-Culver H: Long-term survival differences for bronchiolo-alveolar carcinoma patients with ipsilateral intrapulmonary metastasis at diagnosis. Ann Oncol; 2006 Aug;17(8):1255-62
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  • [Title] Long-term survival differences for bronchiolo-alveolar carcinoma patients with ipsilateral intrapulmonary metastasis at diagnosis.
  • BACKGROUND: It has been suggested that the current staging system does not accurately reflect survival outcomes for advanced bronchiolo-alveolar carcinoma (BAC) patients.
  • Overall survival (OS) and lung cancer-specific survival (LCSS) univariate analyses were conducted using the Kaplan-Meier method.

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  • (PMID = 16766595.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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72. Goo JM, Kim HY, Lee JW, Lee HJ, Lee CH, Lee KW, Kim TJ, Lim KY, Park SH, Bae KT: Is the computer-aided detection scheme for lung nodule also useful in detecting lung cancer? J Comput Assist Tomogr; 2008 Jul-Aug;32(4):570-5
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  • [Title] Is the computer-aided detection scheme for lung nodule also useful in detecting lung cancer?
  • OBJECTIVE: To evaluate the impact of a computer-aided diagnosis (CAD) system on the performance of observers for the detection of both lung nodules and lung cancers.
  • Database included 23 lung cancers (long diameter <20 mm), nodules stable for at least 2 years, and normal cases.
  • RESULTS: The performance of detecting lung nodules was increased significantly with CAD for all radiologists and subgroups (P < 0.01).
  • Although the overall performance of detecting lung cancers was not affected significantly with the use of CAD (P > 0.05), 4 lung cancers missed by 3 residents on their initial observation were additionally detected with CAD.
  • Eighteen of 23 lung cancers were detected by CAD itself.
  • CONCLUSIONS: The overall radiologists' performance of detecting lung nodules was improved significantly with the use of CAD, whereas no statistical significance was observed for the detection of lung cancers.
  • The use of CAD, however, contributed to the detection of additional lung cancers for less experienced readers.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Carcinoma, Non-Small-Cell Lung / diagnosis. Diagnosis, Computer-Assisted / methods. Lung Neoplasms / diagnosis. Radiographic Image Interpretation, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Imaging, Three-Dimensional / methods. Lung / radiography. Male. Middle Aged. Observer Variation. Reference Standards. Reproducibility of Results. Retrospective Studies


73. Cheung WY, Hwang DM, Chung TB, Johnston MR, Leighl NB: Initial treatment strategies and outcomes for multifocal bronchioloalveolar carcinoma. Clin Lung Cancer; 2009 May;10(3):187-92
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  • Median age at diagnosis was 65 years; the majority of the patients were female (64%), were non-Asian (82%), and had a smoking history (66%).
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / therapy. Lung Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / therapy. Female. Humans. Male. Middle Aged. Multivariate Analysis

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  • (PMID = 19443339.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. West H: Emerging approaches to advanced bronchioloalveolar carcinoma. Curr Treat Options Oncol; 2006 Jan;7(1):69-76
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  • Bronchioloalveolar carcinoma (BAC) is a subtype of non-small cell lung adenocarcinoma that has distinct epidemiologic, histologic, radiographic, and clinical features.
  • The strict pathologic definition requires an absence of any invasion through the basement membrane into pulmonary parenchyma, but there is a growing consensus based on recent clinical studies that this diagnosis should be considered to be based on the clinical features of diffuse ground-glass opacities with minimal or no extra-thoracic spread and histology demonstrating adenocarcinoma with a lepidic growth pattern characteristic of BAC, even if there is a component of invasive adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Antineoplastic Agents / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology

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  • (PMID = 16343370.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 58
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75. Ramos SG, Barbosa GH, Tavora FR, Jeudy J, Torres LA, Tone LG, Trad CS: Bronchioloalveolar carcinoma arising in a congenital pulmonary airway malformation in a child: case report with an update of this association. J Pediatr Surg; 2007 May;42(5):E1-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Cystic Adenomatoid Malformation of Lung, Congenital / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Fatal Outcome. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17502169.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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76. Felner KJ, Wieczorek R, Kline M, Smith RL, Sidhu GS: Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules. Int J Surg Pathol; 2006 Jul;14(3):229-33
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  • [Title] Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules.
  • Thoracoscopic biopsy revealed multiple discrete nodules in the pleura and lung.
  • The latter consisted of tall columnar malignant cells arranged on alveolar surfaces in a lepidic growth pattern.
  • Mucin filled the alveolar lumina, both in the nodules and surrounding lung.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Mesothelioma / diagnosis. Pleural Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Hyaluronic Acid / metabolism. Male. Microscopy, Electron, Transmission. Microvilli / ultrastructure. Mucins / metabolism. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 16959710.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 9004-61-9 / Hyaluronic Acid
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77. Patsios D, Roberts HC, Paul NS, Chung T, Herman SJ, Pereira A, Weisbrod G: Pictorial review of the many faces of bronchioloalveolar cell carcinoma. Br J Radiol; 2007 Dec;80(960):1015-23
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  • Bronchioloalveolar cell carcinoma (BAC) has a varied appearance on CT that often leads to an incorrect or delayed diagnosis.
  • These features should alert the radiologist to the diagnosis of BAC.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography

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  • (PMID = 17940131.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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78. Tasci S, Lentini S, Manka R, Friedrichs N, Lüderitz B: [Progressive upper lobe consolidation in a 73-year old healthy woman]. Internist (Berl); 2005 Feb;46(2):195-201
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  • CT-scan and bronchoscopy with bronchoalveolar lavage could not yield a specific diagnosis.
  • Due to progression of the consolidation in a CT scan after 10 weeks another bronchoscopy with transbronchial biopsy was performed and yielded bronchiolo-alveolar carcinoma.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnostic imaging. Incidental Findings. Lung Neoplasms / diagnostic imaging. Pacemaker, Artificial. Sick Sinus Syndrome / therapy. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Biopsy. Bronchoalveolar Lavage Fluid. Bronchoscopy. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Lung / pathology. Lymph Node Excision. Neoplasm Staging. Pneumonectomy


79. Erickson TM, Koeppe JR, Miller YE, Stuart RW, Camidge DR: Bronchioloalveolar carcinoma presenting as chronic progressive pulmonary infiltrates in a woman with HIV: a diagnosis worth making. J Thorac Oncol; 2008 Nov;3(11):1353-5
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  • [Title] Bronchioloalveolar carcinoma presenting as chronic progressive pulmonary infiltrates in a woman with HIV: a diagnosis worth making.
  • After 14 months a solitary lung nodule developed which was excised.
  • This demonstrated an invasive adenocarcinoma with an activating epidermal growth factor receptor mutation (exon 19 deletion).
  • We discuss the diagnosis and treatment of lung cancer in HIV-positive populations and review the general and specific characteristics of bronchioloalveolar carcinoma, including response to epidermal growth factor receptor inhibitors, and known mechanisms of acquired resistance.
  • The predilection for lung cancer in HIV-positive patients, the diffuse nature of bronchioloalveolar carcinoma that can mimic infectious etiologies and the potential for dramatic responses to therapy make this an important diagnosis to consider in this setting.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. HIV / pathogenicity. HIV Infections / complications. Lung Diseases, Interstitial / diagnosis
  • [MeSH-minor] Chronic Disease. Diagnosis, Differential. Erlotinib Hydrochloride. Female. Humans. Middle Aged. Mutation / genetics. Prognosis. Protein Kinase Inhibitors / therapeutic use. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors


80. Travis WD, Garg K, Franklin WA, Wistuba II, Sabloff B, Noguchi M, Kakinuma R, Zakowski M, Ginsberg M, Padera R, Jacobson F, Johnson BE, Hirsch F, Brambilla E, Flieder DB, Geisinger KR, Thunnisen F, Kerr K, Yankelevitz D, Franks TJ, Galvin JR, Henderson DW, Nicholson AG, Hasleton PS, Roggli V, Tsao MS, Cappuzzo F, Vazquez M: Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol; 2005 May 10;23(14):3279-87
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  • [Title] Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.
  • PURPOSE: To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC).
  • METHODS: A pathology/CT review panel of pathologists and radiologists met during a November 2004 International Association for the Study of Lung Cancer/American Society of Clinical Oncology consensus workshop in New York.
  • The purpose was to determine if existing data was sufficient to propose modification of criteria for adenocarcinoma and BAC as newly published in the 2004 WHO Classification of Lung Tumors, and to address the pathologic/radiologic concept of diffuse/multicentric BAC.
  • Most lung adenocarcinomas with a BAC pattern are not pure BAC, but rather adenocarcinoma, mixed subtype with invasive patterns.
  • The percent of BAC versus invasive components in lung adenocarcinomas appears to be prognostically important.
  • While recognition of a BAC component is possible, the diagnosis of BAC with exclusion of invasive adenocarcinoma cannot be made by small biopsy or cytology specimens.
  • CONCLUSION: There is a need to work toward a mutual understanding and consensus between pathologists, clinicians, and researchers with the use of the term BAC versus adenocarcinoma.
  • Hopefully, this work will allow definition of a category of adenocarcinoma, mixed subtype with predominant BAC/minimal invasion and a favorable prognosis.
  • [MeSH-major] Adenocarcinoma / radiography. Lung Neoplasms / radiography
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Humans. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 15886315.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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81. Lyons G, Quadrelli S, Chimondegy D, Iotti A, Silva C: [Bronchioalveolar carcinoma: five year survival]. Medicina (B Aires); 2006;66(4):313-8
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  • The epidemiology and prognosis of bronchioalveolar carcinoma (BAC) is different from adenocarcinoma.
  • We studied 28 patients who underwent surgical resection and in whom a final histologic diagnosis of bronchioalveolar carcinoma was made.
  • Sixty one percent of patients were asymptomatic at the time of diagnosis.
  • Bronchoscopy provided the diagnosis only in 4/26 patients.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / mortality. Lung Neoplasms / mortality
  • [MeSH-minor] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Bronchoscopy. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 16977966.001).
  • [ISSN] 0025-7680
  • [Journal-full-title] Medicina
  • [ISO-abbreviation] Medicina (B Aires)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Argentina
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82. Cobo Dols M, Gil Calle S, Alés Díaz I, Villar Chamorro E, Alcaide García J, Gutiérrez Calderón V, Benavides Orgaz M: Bronchiolitis obliterans organizing pneumonia simulating progression in bronchioloalveolar carcinoma. Clin Transl Oncol; 2006 Feb;8(2):133-5
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  • The diagnosis of BOOP requires the presence of a combination of pathological, clinical, and radiological features.
  • We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Cryptogenic Organizing Pneumonia / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Anti-Inflammatory Agents / therapeutic use. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Diagnosis, Differential. Disease Progression. Humans. Male. Methylprednisolone / therapeutic use. Middle Aged. Respiratory Insufficiency / etiology. Taxoids / administration & dosage. Tomography, X-Ray Computed

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  • (PMID = 16632429.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Taxoids; 0W860991D6 / Deoxycytidine; 15H5577CQD / docetaxel; B76N6SBZ8R / gemcitabine; X4W7ZR7023 / Methylprednisolone
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83. Misao T, Minamoto K, Nakano H, Yamane M, Yamamoto Y, Satoh K: Effect of gravitation for detection of bronchioloalveolar carcinoma on computed tomography. Jpn J Thorac Cardiovasc Surg; 2005 Jun;53(6):309-12
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  • Middle lobectomy with video-assisted thoracoscopic surgery (VATS) was undertaken, and pathological diagnosis was a bronchioloalveolar carcinoma (BAC) in stage IA.
  • A follow-up CT a year following the surgery revealed localized GGO in area S6 of the left lung.
  • Left extended S6 segmentectomy with VATS was performed, and pathological diagnosis was a BAC in stage IA.
  • As GGO existing in a gravitation-dependent area may be masked by the gravitation-dependent density, a change of the scanning position may lead to a proper detection of the tumor for the diagnosis of BAC.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Gravitation. Lung Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 15997753.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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84. Okada M: Invited commentary. Ann Thorac Surg; 2009 Oct;88(4):1111
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Diagnosis, Differential. Disease-Free Survival. Humans. Intraoperative Period. Japan / epidemiology. Survival Rate / trends. Treatment Outcome

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  • [CommentOn] Ann Thorac Surg. 2009 Oct;88(4):1106-11 [19766789.001]
  • (PMID = 19766790.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Netherlands
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85. Vasile E, Tibaldi C, Chella A, Falcone A: Erlotinib after failure of gefitinib in patients with advanced non-small cell lung cancer previously responding to gefitinib. J Thorac Oncol; 2008 Aug;3(8):912-4
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  • [Title] Erlotinib after failure of gefitinib in patients with advanced non-small cell lung cancer previously responding to gefitinib.
  • BACKGROUND: Gefitinib and erlotinib are two orally active epidermal growth factor receptor tyrosine kinase inhibitors used in the treatment of advanced non-small cell lung cancer (NSCLC).
  • RESULTS: Four patients were women; histologic diagnosis was adenocarcinoma in four cases and bronchoalveolar carcinoma or unspecified NSCLC in two cases each.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Protein Kinase Inhibitors / therapeutic use. Quinazolines / therapeutic use
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Aged. Aged, 80 and over. Erlotinib Hydrochloride. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Survival Rate. Treatment Outcome

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  • (PMID = 18670311.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
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86. Bryant AS, Cerfolio RJ: The maximum standardized uptake values on integrated FDG-PET/CT is useful in differentiating benign from malignant pulmonary nodules. Ann Thorac Surg; 2006 Sep;82(3):1016-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Lung Diseases / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals / pharmacokinetics. Solitary Pulmonary Nodule / radionuclide imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Bronchiolo-Alveolar / radionuclide imaging. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Aged. Carcinoid Tumor / pathology. Carcinoid Tumor / radiography. Carcinoid Tumor / radionuclide imaging. Carcinoid Tumor / surgery. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / radiography. Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Carcinoma, Non-Small-Cell Lung / surgery. Carcinoma, Renal Cell / radiography. Carcinoma, Renal Cell / radionuclide imaging. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Frozen Sections. Humans. Lung Diseases, Fungal / radiography. Lung Diseases, Fungal / radionuclide imaging. Lymphatic Metastasis. Male. Middle Aged. Thoracic Surgery, Video-Assisted

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  • (PMID = 16928527.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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87. Griffiths DJ, Martineau HM, Cousens C: Pathology and pathogenesis of ovine pulmonary adenocarcinoma. J Comp Pathol; 2010 May;142(4):260-83
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  • [Title] Pathology and pathogenesis of ovine pulmonary adenocarcinoma.
  • Ovine pulmonary adenocarcinoma (OPA), also known as jaagsiekte, is a transmissible lung tumour of sheep caused by jaagsiekte sheep retrovirus (JSRV).
  • JSRV induces neoplastic transformation of alveolar and bronchiolar secretory epithelial cells and the resulting tumours can grow to occupy a significant portion of the lung.
  • Tumour growth is frequently accompanied by the overproduction of fluid in the lung, which further compromises normal respiration.
  • In addition to its veterinary importance, OPA is regarded as a potential large animal model for human lung adenocarcinoma and this has stimulated research into the pathogenesis of the ovine disease.
  • The recent advances in understanding JSRV and the pathogenesis of OPA should lead to novel strategies for diagnosis and control of this disease and for its exploitation as a comparative model for human lung cancer.
  • [MeSH-major] Adenocarcinoma / virology. Jaagsiekte sheep retrovirus / physiology. Pulmonary Adenomatosis, Ovine. Sheep Diseases / virology
  • [MeSH-minor] Animals. Body Fluids / virology. Epithelial Cells / pathology. Epithelial Cells / virology. Humans. Lung / pathology. Lung / virology. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Lung Neoplasms / virology. Models, Animal. Sheep / genetics. Sheep / virology. Sheep, Domestic / genetics. Sheep, Domestic / virology

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20163805.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 171
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88. Ulmeanu R, Mihăltan F, Crişan E, Alexe M, Grigore P, Andreescu I, Galbenu P, Leonte D: [Practical issues of transbronchial lung biopsy (TLB) in pneumology]. Pneumologia; 2007 Apr-Jun;56(2):59-67
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  • [Title] [Practical issues of transbronchial lung biopsy (TLB) in pneumology].
  • METHOD: We present a survey of 78 TLB which have been performed in Bronchology Service (during 2003-2005) for diffuse interstitial lung diseases--70 cases or located diseases--8 cases; TLB was not performed for solitary peripherally opacities because we have no radiological device with mobile arm (for good position of forceps).
  • RESULTS: In 78% of cases we obtained illustrative lung tissue and in 22% of cases we prelevated just bronchial wall.
  • Histological confirmation was obtained for 53% of cases; 47% of cases have as result lung tissue without significant modifications.
  • Histological diagnosis was obtain in 41% of cases.
  • The diagnosis of lung pathology was: diffuse lung fibrosis, tuberculosis, sarcoidosis stage II-III, malignant lymphoma, carcinomatosis, undifferentiated carcinoma, bronchioloalveolar carcinoma, squamous carcinoma, adenocarcinoma.
  • The international guidelines request that the TLB has to be made before the thoracoscopy or the thoracotomy; because of the small size of prelevated fragments the diagnosis sensibility is variable.
  • Our results for the 78 cases are comparable with the international data from literature both from the point of view of the diagnosis and the complications.
  • [MeSH-major] Biopsy, Needle / methods. Bronchoscopy. Lung Diseases / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Granulomatosis with Polyangiitis / pathology. Health Surveys. Humans. Lung Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Practice Guidelines as Topic. Pulmonary Fibrosis / pathology. Sarcoidosis, Pulmonary / pathology. Sensitivity and Specificity. Tuberculosis, Pulmonary / pathology

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  • (PMID = 18019749.001).
  • [ISSN] 2067-2993
  • [Journal-full-title] Pneumologia (Bucharest, Romania)
  • [ISO-abbreviation] Pneumologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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89. Isobe K, Hata Y, Sugino K, Takai Y, Shibuya K, Homma S: [Usefulness of FDG-PET for diagnosis of lung cancer associated with interstitial pneumonia]. Nihon Kokyuki Gakkai Zasshi; 2009 Apr;47(4):278-85
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  • [Title] [Usefulness of FDG-PET for diagnosis of lung cancer associated with interstitial pneumonia].
  • AIM: The aim of this study was to demonstrate the usefulness of FDG-PET for diagnosis of lung cancer associated with interstitial pneumonia (IP), clinicopathologically.
  • SUBJECTS AND METHODS: 32 patients with IP-associated lung cancer (IP-LC group) and 26 patients with IP not associated with lung cancer (IP group) underwent 18-fluorodeoxyglucose positron emission tomography (FDG-PET) for diagnostic procedure from April 2004 through October 2007.
  • Standard uptake values (SUV) were compared between IP and lung cancer fields in two groups.
  • In addition, expression of Glut-1, MIB-1, and p53 in the resected lung tissues (n=10) were analyzed.
  • RESULTS: There was a significant difference in SUVs between lung cancer fields and IP fields.
  • However, it was difficult to distinguish the fields of well-differentiated adenocarcinoma from IP by SUV.
  • Red blood cells in the vessels along the alveolar walls, hyperplastic alveolar type II cells, and squamous metaplastic cells in the fibrotic lung tissues revealed expression of Glut-1.
  • In addition, hyperplastic alveolar type II cells and metaplastic cells also revealed expression of MIB-1 and p53.
  • CONCLUSION: The elevation of SUV in IP fields can be caused by neovascularization and/or hyperplasia of alveolar type II cells and metaplastic cells in the fibrotic lesions.
  • [MeSH-major] Fluorodeoxyglucose F18. Lung Diseases, Interstitial / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 19455956.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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90. Noguchi M, Minami Y, Iijima T, Matsuno Y: Reproducibility of the diagnosis of small adenocarcinoma of the lung and usefulness of an educational program for the diagnostic criteria. Pathol Int; 2005 Jan;55(1):8-13
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  • [Title] Reproducibility of the diagnosis of small adenocarcinoma of the lung and usefulness of an educational program for the diagnostic criteria.
  • Using 32 small adenocarcinomas of the lung including bronchioloalveolar carcinoma (BAC), the reproducibility of diagnosis by the modified diagnostic criteria for small adenocarcinoma (Cancer 75; 2844, 1995) and the effectiveness of an educational program for 27 volunteer general pathologists were examined.
  • The average coincidence rate of the diagnosis before and after the program was 42.4% and 56.6%, respectively.
  • In contrast, the average coincidence rate of six lung cancer specialists was 71.4%, and this was significantly higher than that for general pathologists after the program (P < 0.05).
  • When the cases were divided into two groups (in situ adenocarcinoma (BAC and BAC with alveolar collapse) and early invasive adenocarcinoma), the average coincidence rate for the general pathologists after the program increased to 85.3%, which was significantly higher than that before the program (80.3%; P < 0.05).
  • This trial was thought to provide a theoretical background for the histological diagnosis of peripheral type adenocarcinoma of the lung and to justify the existing diagnostic criteria.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma in Situ / diagnosis. Lung Neoplasms / diagnosis. Pathology, Surgical / education
  • [MeSH-minor] Diagnosis, Differential. Humans. Reproducibility of Results

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  • (PMID = 15660697.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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91. Aida S, Ohara I, Shimazaki H, Dai Y, Ogata S, Ozeki Y, Tamai S: Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases. Am J Surg Pathol; 2008 Oct;32(10):1489-94
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  • [Title] Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases.
  • We report 3 cases of solitary papillomas located in peripheral regions of the lung that are extremely rare in the literature.
  • The neoplastic epithelium extended to the alveolar region and showed a similar appearance to bronchioloalveolar or papillary type adenocarcinomas.
  • For differential diagnosis, it is noteworthy that endobronchiolar papillomatous fronds constantly exist and spreading along alveolar walls is limited in adjacent alveoli in peripheral papillomas.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Bronchial Neoplasms / pathology. Lung Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology. Papilloma / pathology. Solitary Pulmonary Nodule / pathology
  • [MeSH-minor] Aged. Bronchi / pathology. Cilia / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Pulmonary Alveoli / pathology. Respiratory Mucosa / pathology

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  • (PMID = 18708941.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Edey AJ, Hansell DM: Incidentally detected small pulmonary nodules on CT. Clin Radiol; 2009 Sep;64(9):872-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Multiple Pulmonary Nodules / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Calcinosis / radiography. Diagnosis, Differential. Hamartoma / radiography. Humans. Incidental Findings. Lung. Lymph Nodes / pathology. Lymph Nodes / radiography. Middle Aged. Practice Guidelines as Topic. Radiation Dosage. Reproducibility of Results. Risk Factors. Time Factors

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  • (PMID = 19664477.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 78
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93. Dillman RO, Zusman DR, McClure SE: Surgical resection and long-term survival for octogenarians who undergo surgery for non-small-cell lung cancer. Clin Lung Cancer; 2009 Mar;10(2):130-4
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  • [Title] Surgical resection and long-term survival for octogenarians who undergo surgery for non-small-cell lung cancer.
  • PURPOSE: An increasing proportion of newly diagnosed non-small-cell lung cancer (NSCLC) patients are octogenarians.
  • It has been questioned whether older patients benefit from surgical resection of lung cancer to the same extent as younger patients.
  • PATIENTS AND METHODS: We conducted a single-institution, retrospective analysis of patients newly diagnosed with NSCLC from 2000-2006, who underwent surgical resection of their lung cancer in Hoag Hospital.
  • RESULTS: The proportion of patients who had local disease at diagnosis was higher for octogenarians compared with younger patients (33.6% vs. 26.6%; P = .021), but the resection rate for octogenarians was lower (64% vs. 83%; P = .0003).
  • CONCLUSION: Non-small-cell lung cancer patients < 80 years of age were less likely to undergo potentially curative surgery, but survival for octogenarians who did undergo surgical resection was comparable to younger age groups.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / mortality. Lung Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / mortality. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Age Factors. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 19362957.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Shvartsbeyn M, Edelman MJ: Pemetrexed-induced typhlitis in non-small cell lung cancer. J Thorac Oncol; 2008 Oct;3(10):1188-90
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  • [Title] Pemetrexed-induced typhlitis in non-small cell lung cancer.
  • Food and Drug Administration-approved as a second line, single-agent treatment of recurrent metastatic non-small cell lung cancer.
  • The diagnosis is supported by the findings of bowel wall thickening on computed tomographic imaging.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Carcinoma, Non-Small-Cell Lung / drug therapy. Glutamates / adverse effects. Guanine / analogs & derivatives. Lung Neoplasms / drug therapy. Typhlitis / chemically induced
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / complications. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adult. Female. Humans. Pemetrexed. Thymidylate Synthase / antagonists & inhibitors. Tomography, X-Ray Computed

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  • (PMID = 18827618.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; EC 2.1.1.45 / Thymidylate Synthase
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95. Raz DJ, Jablons DM: Bronchioloalveolar carcinoma is not associated with younger age at diagnosis: an analysis of the SEER database. J Thorac Oncol; 2006 May;1(4):339-43
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  • [Title] Bronchioloalveolar carcinoma is not associated with younger age at diagnosis: an analysis of the SEER database.
  • INTRODUCTION: Bronchioloalveolar carcinoma (BAC) is a unique subtype of non-small cell lung cancer (NSCLC) that is associated with female gender, Asian ethnicity, and never-smoking status.
  • Although BAC is commonly reported to occur more frequently in young people with lung cancer, there is a lack of evidence to support this association.
  • METHODS: We analyzed the association between age at diagnosis and NSCLC histology among 293,417 incident cases of NSCLC in the Surveillance Epidemiology, and End Results (SEER) database during the years 1973 to 2002.
  • Although a greater percentage of women and Asian patients with lung cancer were younger than 50 years old, the proportion of patients with BAC was similar to the proportion of men and non-Asians with BAC.
  • Finally, the prevalence of BAC histology among patients younger than 50 years did not change significantly after revision of the 1999 World Health Organization pathologic criteria for the diagnosis of BAC (risk ratio 0.93 versus 0.87, p = 0.31).
  • CONCLUSION: BAC is not associated with a younger mean age at diagnosis, nor is it associated with an age of less than 50 years at diagnosis.

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  • (PMID = 17409881.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA093708-02; United States / NCI NIH HHS / CA / R01 CA093708; United States / NCI NIH HHS / CA / R01 CA093708-02
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Sabloff BS, Wistuba II, Erasmus JJ: Cystic bronchioloalveolar cell carcinoma. J Thorac Imaging; 2005 May;20(2):110-4
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  • Bronchioloalveolar cell carcinomas (BACs), a subset of primary lung adenocarcinomas, are uncommon.
  • Similar to other non-small cell lung cancers, patients with BAC are usually 40-70 years of age.
  • Distinguishing features relative to other non-small cell lung cancers include occurrence in young patients, a higher relative predominance in women, and weaker association with smoking.
  • Knowledge of the spectrum of radiologic manifestations of BAC and correlation with clinical history are important in suggesting the diagnosis and preventing misinterpretation.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle / methods. Cough / etiology. Diagnosis, Differential. Female. Humans. Lung / pathology. Lung / radiography. Male. Middle Aged

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  • (PMID = 15818211.001).
  • [ISSN] 0883-5993
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Shaw ND, Hoover EL: Postoperative pleural effusion in bronchioloalveolar cancer. Ann Thorac Surg; 2005 Sep;80(3):1124-6
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  • Bronchioloalveolar carcinoma occasionally presents with bronchorrhea and can appear on roentgenogram as cavitary lesions similar to a lung abscess.
  • We present a case of multifocal, cavitary bronchioloalveolar cancer, which was originally treated unsuccessfully as lung abscesses.
  • This report chronicles our difficulty with diagnosis and management and suggests recommendations for future providers.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / complications. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Pleural Effusion / etiology

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  • (PMID = 16122510.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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98. Lebensburger J, Katzenstein H, Jenkins JJ, Rodriguez-Galindo C: Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors. Pediatr Blood Cancer; 2009 Sep;53(3):499-501
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  • BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / etiology. Bone Neoplasms / therapy. Lung Neoplasms / etiology. Neoplasms, Second Primary / etiology. Osteosarcoma / therapy. Survivors

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19418544.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 21765; United States / NCI NIH HHS / CA / P30 CA23099
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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99. Priest JR, Williams GM, Hill DA, Dehner LP, Jaffé A: Pulmonary cysts in early childhood and the risk of malignancy. Pediatr Pulmonol; 2009 Jan;44(1):14-30
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  • Surgery for congenital and early childhood lung cysts is often dictated by symptoms such as respiratory distress, infection or pneumothorax.
  • Pleuropulmonary blastoma (PPB) is the most frequent malignancy associated with childhood lung cysts.
  • The earliest manifestation of PPB is a malignant lung cyst in young children, clinically and radiographically indistinguishable from benign congenital lung cysts.
  • Numerous reports of "malignancy in a congenital lung cyst" are now understood as the characteristic progression of cystic PPB.
  • Detailed family history may reveal the hallmarks of PPB in the patient or young relatives: a unique constellation of diseases including lung cysts, cystic nephroma, childhood cancers, stromal sex-chord ovarian tumors, seminomas or dysgerminomas, intestinal polyps, thyroid hyperplasias, and hamartomas.
  • Pneumothorax and multifocal/bilateral lung cysts also characterize PPB.
  • These diagnoses predict that a lung cyst is more likely PPB than a benign congenital cyst.
  • Patients fitting this pattern deserve histologic diagnosis.
  • [MeSH-major] Cysts / pathology. Lung Diseases / pathology. Lung Neoplasms / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Child. Diagnosis, Differential. Genetic Predisposition to Disease. Humans. Pulmonary Blastoma / pathology. Risk Factors

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • [CommentIn] Pediatr Pulmonol. 2010 Jan;45(1):103; author reply 104 [19960525.001]
  • (PMID = 19061226.001).
  • [ISSN] 1099-0496
  • [Journal-full-title] Pediatric pulmonology
  • [ISO-abbreviation] Pediatr. Pulmonol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 94
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100. Luo BJ, Lü PX, Zhou XH, Pan JS: [CT image features of 46 cases with pneumonic-type lung cancers]. Zhonghua Zhong Liu Za Zhi; 2007 Nov;29(11):860-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [CT image features of 46 cases with pneumonic-type lung cancers].
  • OBJECTIVE: To analyze the CT image features of pneumonic-type lung cancer and to reduce misdiagnosis.
  • METHODS: The CT findings of 46 patients with pneumonic-type lung cancer were retrospectively reviewed, and CT image in the differential diagnosis of this special kind of disease was evaluated.
  • CONCLUSION: CT findings including lower lobe distribution, homogeneous consolidation, narrow air bronchogram, well defined ground-glass and CT angiogram are helpful in differentiating pneumonic-type lung cancer from various kinds of infection.
  • However, most of CT manifestations of pneumonic-type lung cancer are not specific.
  • Therefore, it's necessary to combine CT findings with other clinical data when making diagnosis.
  • [MeSH-major] Adenocarcinoma / radiography. Diagnostic Errors. Lung Neoplasms / radiography. Pneumonia, Bacterial / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Mucinous / radiography. Adenocarcinoma, Papillary / radiography. Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lung / radiography. Male. Middle Aged. Radiographic Image Enhancement. Tuberculosis, Pulmonary / radiography

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  • (PMID = 18396648.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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