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1. Raz DJ, Zell JA, Karnezis AN, Odisho A, Ignatius Ou SH, Anton-Culver H, Jablons DM: Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer. J Thorac Oncol; 2006 Nov;1(9):943-8
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  • [Title] Misclassification of bronchioloalveolar carcinoma with cytologic diagnosis of lung cancer.
  • INTRODUCTION: Cytology is commonly used to diagnose non-small cell lung cancer (NSCLC) but is an inaccurate means of diagnosis of bronchioloalveolar carcinoma (BAC).
  • The aims of this study were to calculate the sensitivity and specificity of cytologic diagnosis of BAC and to estimate the misclassification of BAC as other subtypes of NSCLC.
  • METHODS: Preoperative fine-needle aspiration cytology diagnoses were compared to histology diagnoses in 222 patients, including 51 patients with pure or mixed BAC, who underwent lung resection for NSCLC at our institution since 1999.
  • RESULTS: The sensitivity and specificity of a cytologic diagnosis of BAC were 12% and 99%, respectively.
  • Based on cytologic diagnosis, 63% of BAC was misclassified as adenocarcinoma, and 18% was misclassified as undifferentiated NSCLC.
  • CONCLUSIONS: Diagnosis of NSCLC by cytology alone results in significant misclassification of BAC, most commonly as adenocarcinoma or undifferentiated NSCLC.
  • Because patients with BAC respond differently to certain treatments such as endothelial growth factor receptor inhibitors and surgical resection of multifocal lung cancer, misclassification of BAC may have important therapeutic implications.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy, Fine-Needle. Cohort Studies. Cytodiagnosis / classification. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Preoperative Care / methods. Probability. Retrospective Studies. Risk Assessment. Sensitivity and Specificity

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  • (PMID = 17409976.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA093708-04; United States / NCI NIH HHS / CA / R01 CA093708-02; United States / NCI NIH HHS / CA / R01 CA093708; United States / NCI NIH HHS / CA / T32 CA108462; United States / NCI NIH HHS / CA / T32 CA108462-01
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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2. Glynn C, Zakowski MF, Ginsberg MS: Are there imaging characteristics associated with epidermal growth factor receptor and KRAS mutations in patients with adenocarcinoma of the lung with bronchioloalveolar features? J Thorac Oncol; 2010 Mar;5(3):344-8
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  • [Title] Are there imaging characteristics associated with epidermal growth factor receptor and KRAS mutations in patients with adenocarcinoma of the lung with bronchioloalveolar features?
  • PURPOSE: To identify any particular imaging features on computed tomography (CT) in patients with confirmed adenocarcinoma with bronchioloalveolar (ABAC) features and known epidermal growth factor receptor (EGFR) and KRAS mutations.
  • Seventy-seven pulmonary nodules in 64 patients with a histologic diagnosis of ABAC and known EGFR or KRAS mutation status were assessed.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / genetics. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / genetics. Lung Neoplasms / radiography. Mutation / genetics. Proto-Oncogene Proteins / genetics. Receptor, Epidermal Growth Factor / genetics. ras Proteins / genetics

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  • (PMID = 20087229.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRAS protein, human; 0 / Proto-Oncogene Proteins; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.6.5.2 / ras Proteins
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3. Garfield DH, Cadranel J: The importance of distinguishing mucinous and nonmucinous bronchioloalveolar carcinomas. Lung; 2009 May-Jun;187(3):207-8
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  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Focal Adhesion Kinase 1 / analysis. Humans. PTEN Phosphohydrolase / analysis

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  • [CommentOn] Lung. 2009 Mar-Apr;187(2):104-9 [19242756.001]
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  • (PMID = 19408043.001).
  • [ISSN] 1432-1750
  • [Journal-full-title] Lung
  • [ISO-abbreviation] Lung
  • [Language] eng
  • [Publication-type] Editorial; Comment
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.2 / Focal Adhesion Kinase 1; EC 2.7.10.2 / PTK2 protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.1.3.67 / PTEN protein, human
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4. Lourenço R, Camacho R, Barata MJ, Canário D, Gaspar A, Cyrne C: CT-guided percutaneous transthoracic biopsy in the evaluation of undetermined pulmonary lesions. Rev Port Pneumol; 2006 Sep-Oct;12(5):503-24
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  • 72 FNAB were considered adequate for cytology diagnosis; 72% of them positive for malignancy.
  • All malignant lesions were nodules: 20 adenocarcinoma, 13 non-small cell lung cancer (SCLC), 10 epidermoid tumours, 5 small-cell lung cancer, 2 carcinoids, 1 bronchiolo alveolar carcinoma, 1 malignant mesothelioma and 8 metastasis.
  • [MeSH-major] Biopsy, Needle / methods. Lung Diseases / diagnosis. Lung Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 17117322.001).
  • [ISSN] 0873-2159
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Portugal
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5. Oda S, Awai K, Liu D, Nakaura T, Yanaga Y, Nomori H, Yamashita Y: Ground-glass opacities on thin-section helical CT: differentiation between bronchioloalveolar carcinoma and atypical adenomatous hyperplasia. AJR Am J Roentgenol; 2008 May;190(5):1363-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Solitary Pulmonary Nodule / radiography. Tomography, Spiral Computed
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Hyperplasia / radiography. Male. Middle Aged. Observer Variation. Retrospective Studies

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  • (PMID = 18430856.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Tang XW, Huang HY, Zhan SH, Sun XW, Shi XL, Sun AN, Shen ZY, Kang SY, Jin ZM, Qiu HY, Miao M, Fu ZZ, Han Y, Chen SN, Xue SL, Ma X, Liu YJ, Hu XH, Zhou HF, Wu DP: [Surgical treatment and pathological findings of hematological malignancies patients complicated with lung diseases.]. Zhonghua Xue Ye Xue Za Zhi; 2009 Dec;30(12):829-33
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  • [Title] [Surgical treatment and pathological findings of hematological malignancies patients complicated with lung diseases.].
  • RESULTS: Pathological examination confirmed: aspergillus infection in 9 patients, sub-acute inflammation (fibrosis and hematoma formation) in 3, and each in 1 of pulmonary infarction with granulomatous tissue in the periphery; granulomatous inflammation with calcified tubercle; alveolar dilation and hemorrhage, interstitial fibrosis and focal vasculitis; intercostal neurilemmoma; and moderate-differentiated adenocarcinoma accompanied by intrapulmonary metastasis.
  • The coincidence rate of pre- and post-operative diagnosis was 9/14 (64.3%).
  • CONCLUSION: Hematological malignancies with persistent and/or resistant pulmonary infection, hemoptysis, or unexplained lung diseases, should be treated in time by surgery operation to effectively eliminate residual disease and obtain a definitive diagnosis, so as to create a prerequisite condition for the following treatments.
  • [MeSH-minor] Aspergillosis / diagnosis. Hematopoietic Stem Cell Transplantation. Humans. Lung Diseases

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  • (PMID = 20193605.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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7. Saad RS, Liu YL, Silverman JF: Distribution of basal/myoepithelial markers in benign and malignant bronchioloalveolar proliferations of the lung. Appl Immunohistochem Mol Morphol; 2010 May;18(3):219-25
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  • [Title] Distribution of basal/myoepithelial markers in benign and malignant bronchioloalveolar proliferations of the lung.
  • We investigated the staining pattern of commonly used basal cell/myoepithelial markers, such as p63 (a p53-homologous nuclear protein), basal cell-specific cytokeratin antibody (34betaE12, K903), and smooth muscle myosin heavy chain (SMMHC) in benign and malignant bronchioloalveolar proliferations of the lung.
  • We studied 85 lung lesions consisting of 35 bronchioloalveolar carcinoma, 30 well-differentiated adenocarcinoma, and 20 cases of benign lung lesions.
  • In normal lung, p63, K903, and SMMHC decorated the basal cells of large and small airways and occasional cells of terminal bronchioles.
  • Respiratory ciliated cells, alveolar epithelial cells, and nonepithelial cells were negative.
  • For adenocarcinoma, a majority of the cases (28/30, 93%) were negative for p63 and K903; however, SMMHC showed artifactual staining in the desmoplastic stroma in 6/30 (20%) cases.

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  • (PMID = 20065853.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 68238-35-7 / Keratins; EC 3.6.1.- / Smooth Muscle Myosins
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8. Altorki NK, Yankelevitz DF, Vazquez MF, Kramer A, Henschke CI: Bronchioloalveolar carcinoma in small pulmonary nodules: clinical relevance. Semin Thorac Cardiovasc Surg; 2005;17(2):123-7
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  • The diagnosis of malignancy in this setting can be challenging to radiologists, surgeons, and occasionally pathologists as well.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / pathology. Solitary Pulmonary Nodule / pathology

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  • (PMID = 16087079.001).
  • [ISSN] 1043-0679
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Park JH, Lee KS, Kim JH, Shim YM, Kim J, Choi YS, Yi CA: Malignant pure pulmonary ground-glass opacity nodules: prognostic implications. Korean J Radiol; 2009 Jan-Feb;10(1):12-20
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  • Differences in patient prognoses were compared for nodule number, size, surgical method, change in size before surgical removal, and histopathological diagnosis by use of Fisher's exact test and Pearson's chi-squared test.
  • RESULTS: Of the 58 patients, 40 patients (69%) were confirmed to have a bronchioloalveolar carcinoma (BAC) and 18 patients (31%) were confirmed to have an adenocarcinoma with a predominant BAC component.
  • Irrespective of nodule size, number, treatment method, change in size before surgical removal and histopathological diagnosis, neither local recurrence nor a metastasis occurred in any of these patients as determined at a follow-up period of 24 months (range; 12-65 months).
  • CONCLUSION: Prognoses in patients with pure GGO malignant pulmonary nodules are excellent, and not significantly different in terms of nodule number, size, surgical method, presence of size change before surgical removal and histopathological diagnosis.
  • [MeSH-major] Lung Neoplasms / radiography. Multiple Pulmonary Nodules / radiography. Solitary Pulmonary Nodule / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / radiography. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Female. Humans. Male. Middle Aged. Prognosis. Young Adult

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  • (PMID = 19182498.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2647178
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10. Popescu I: [Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention]. Pneumologia; 2008 Oct-Dec;57(4):201-8
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  • [Title] [Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention].
  • Early diagnosis of pulmonary cancer is crucial in the fight against this disease.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Antineoplastic Agents / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology. Precancerous Conditions / drug therapy. Precancerous Conditions / pathology
  • [MeSH-minor] Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Humanized. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bevacizumab. Biomarkers, Tumor / metabolism. Bronchoalveolar Lavage. Bronchoscopy / methods. Cetuximab. Early Diagnosis. Erlotinib Hydrochloride. Genes, p16. Humans. Mass Screening. Mutation. Positron-Emission Tomography. Predictive Value of Tests. Quinazolines / administration & dosage. Sensitivity and Specificity. Tomography, Optical Coherence. Treatment Outcome. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19186682.001).
  • [ISSN] 2067-2993
  • [Journal-full-title] Pneumologia (Bucharest, Romania)
  • [ISO-abbreviation] Pneumologia
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Quinazolines; 0 / Tumor Suppressor Protein p53; 2S9ZZM9Q9V / Bevacizumab; DA87705X9K / Erlotinib Hydrochloride; PQX0D8J21J / Cetuximab; S65743JHBS / gefitinib
  • [Number-of-references] 48
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11. Kitada M, Ozawa K, Sato K, Hayashi S, Miyokawa N, Sasajima T: Clear cell carcinoma of the lung. Gen Thorac Cardiovasc Surg; 2010 Feb;58(2):87-90
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  • [Title] Clear cell carcinoma of the lung.
  • We present here in the case of a patient who underwent resection of clear cell carcinoma of the lung, a rare histological type.
  • A screening test of the 71-year-old woman revealed a 2.0-cm lesion in S4 of the right lung with a diagnosis of bronchioloalveolar carcinoma before resection.
  • The histopathological examination showed clear, slightly acidophilic tumor cells rich in fine granular components proliferating in an alveolar fashion.
  • Immunostaining was diagnostically useful, distinguishing clear cell carcinoma from lung metastasis of renal clear cell carcinoma or clear cell squamous cell carcinoma.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Aged. Biopsy. Cell Differentiation. Cell Proliferation. Diagnostic Errors. Female. Humans. Immunohistochemistry. Lymph Node Excision. Neoplasm Staging. Predictive Value of Tests. Thoracic Surgery, Video-Assisted. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20155345.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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12. Uji M, Matsushita H, Watanabe T, Suzumura T: [A case of primary Sjögren's syndrome complicated with lung adenocarcinoma]. Nihon Kokyuki Gakkai Zasshi; 2007 May;45(5):409-12
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  • [Title] [A case of primary Sjögren's syndrome complicated with lung adenocarcinoma].
  • The serum value of carcinoembryonic antigen was highly elevated, so we made a presumed diagnosis of primary non-small lung cancer.
  • The elevated values of serum antibodies against SS-A and SS-B and further examinations resulted in a definitive diagnosis of primary Sjögren's syndrome.
  • Autopsy revealed that the mass shadow was a primary lung adenocarcinoma.
  • Those lesions had bullae, emphysema, and alveolar septae thickened by infiltration of lymphoplasmacytic cells.
  • We raise a possibility that lung cancer might derive from cystic lesions associated with Sjögren's syndrome.
  • [MeSH-major] Adenocarcinoma / complications. Lung Neoplasms / complications. Sjogren's Syndrome / complications

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  • (PMID = 17554985.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Nakamura N, Kobayashi K, Nakamoto M, Kohno T, Sasaki H, Matsuno Y, Yokota J: Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma. Oncogene; 2006 Jul 13;25(30):4245-55
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  • [Title] Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma.
  • To identify tumor markers and differentiation markers for lung adenocarcinoma (AdC), we analysed expression profiles of 14,500 genes against three cases of type II alveolar epithelial cells, bronchiolar epithelial cells, and bronchial epithelial cells, respectively, and 10 cases of AdC cells isolated by laser capture microdissection.
  • Hierarchical clustering analysis indicated that AdC cells and noncancerous lung epithelial cells are significantly different in their expression profiles, and that different sets of differentiation markers are expressed among alveolar, bronchiolar and bronchial epithelial cells.
  • Nine genes were identified as being highly expressed in AdC cells, but not expressed in noncancerous lung epithelial cells.
  • Sixteen genes were identified as differentiation markers for lung epithelial cells.
  • Real-time RT-PCR analysis of 45 lung AdC cases further revealed that expression of four tumor markers in AdC cells was significantly higher than that in noncancerous lung cells and that expression of ten differentiation markers was retained in a considerable fraction of lung AdC cases.
  • Similarities and differences in expression profiles between normal epithelial cells from different lung respiratory compartments and AdC cells demonstrated in this study will be informative for the molecular diagnosis of lung AdC.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / pathology. Biomarkers, Tumor. Cell Differentiation. Lung Neoplasms / diagnosis. Lung Neoplasms / pathology

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  • (PMID = 16491115.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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14. Kim TH, Kim SJ, Ryu YH, Chung SY, Seo JS, Kim YJ, Choi BW, Lee SH, Cho SH: Differential CT features of infectious pneumonia versus bronchioloalveolar carcinoma (BAC) mimicking pneumonia. Eur Radiol; 2006 Aug;16(8):1763-8
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  • The purpose of this study was to evaluate retrospectively the differential CT features of bronchioloalveolar carcinoma (BAC) mimicking pneumonia and infectious pneumonia at the lung periphery.
  • CT images were reviewed in 47 patients with focal areas of parenchymal opacification at the lung periphery.
  • We evaluated the presence of ground-glass attenuation, marginal conspicuity of the lesion, CT angiogram sign, air-bronchogram sign, a bubble-like low-attenuation area within the lesion, presence of pleural thickening and retraction associated with the lesion, presence of pleural effusion and extra-pleural fatty hypertrophy, presence of bronchial wall thickening proximal to the lesion, and air-trapping in the normal lung near the lesion.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnostic imaging. Lung Neoplasms / diagnostic imaging. Pneumonia / diagnostic imaging. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Male. Middle Aged. Predictive Value of Tests. Radiography, Thoracic. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 16418864.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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15. Ohtsuka T, Watanabe K, Kaji M, Naruke T, Suemasu K: A clinicopathological study of resected pulmonary nodules with focal pure ground-glass opacity. Eur J Cardiothorac Surg; 2006 Jul;30(1):160-3
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  • RESULTS: The histological diagnosis was bronchioloalveolar carcinoma (BAC) in 10 patients (12 lesions), atypical adenomatous hyperplasia (AAH) in 15 patients (22 lesions), and focal scar in 1 patient (1 lesion).
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenomatosis, Pulmonary / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoembryonic Antigen / blood. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Palpation. Tomography, X-Ray Computed

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  • (PMID = 16723239.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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16. Niang A, Bonnichon A, Ba-Fall K, Dussart C, Camara P, Vaylet F, Mbaye PS, L'Her P, Sane M, Margery J: [Lung cancer in Senegal]. Med Trop (Mars); 2007 Dec;67(6):651-6
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  • [Title] [Lung cancer in Senegal].
  • In Africa the incidence of lung cancer is rising rapidly.
  • The purpose of this prospective study was to analyze clinical, therapeutic, and prognostic features of lung cancer patients treated at the Principal Hospital in Dakar between 2002 and 2007.
  • The histological diagnosis was squamous cell carcinoma in 23 cases, adenocarcinoma in 14, large-cell carcinoma in 17, small-cell lung cancer in 2, and bronchiolo-alveolar cancer in 1.
  • The much higher rate of histological diagnosis than in the sub-region is due mainly to the availability of trained personnel with access to bronchial endoscopy and CT-scan needle biopsy since September 2003.
  • Lung cancer is a health issue in Dakar, Senegal.
  • [MeSH-major] Carcinoma / epidemiology. Carcinoma / therapy. Lung Neoplasms / epidemiology. Lung Neoplasms / therapy

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  • (PMID = 18300532.001).
  • [ISSN] 0025-682X
  • [Journal-full-title] Médecine tropicale : revue du Corps de santé colonial
  • [ISO-abbreviation] Med Trop (Mars)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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17. Reyes Ojeda MD, López Aznar DJ, Abreu Sánchez P, Uruburu Garcia E, Martínez Carsi C, Sopena Monforte R: [Bronchioloalveolar carcinoma as potencial cause of false negative with PET-FDG]. Rev Esp Med Nucl; 2005 Jul-Aug;24(4):254
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  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radionuclide imaging. Adenocarcinoma, Mucinous / radionuclide imaging. Fluorodeoxyglucose F18. Lung Neoplasms / radionuclide imaging. Neoplasms, Second Primary / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals
  • [MeSH-minor] Carcinoma, Transitional Cell / pathology. Carcinoma, Transitional Cell / secondary. Diagnosis, Differential. Humans. Male. Middle Aged. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16122411.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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18. Allen TC, Moran C: Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. Arch Pathol Lab Med; 2006 May;130(5):721-4
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  • The patients underwent surgery for treatment of adenocarcinoma that was diagnosed preoperatively.
  • Diffuse malignant mesothelioma was suspected on the basis of pleural involvement by tumor with histology differing from that of the adenocarcinoma.
  • The average survival after diagnosis was 6 weeks or less.
  • Length of survival following diagnosis is bleak.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / pathology. Mesothelioma / pathology. Neoplasms, Multiple Primary. Pleural Neoplasms / pathology

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  • (PMID = 16683892.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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19. Kang MJ, Kim MA, Park CM, Lee CH, Goo JM, Lee HJ: Ground-glass nodules found in two patients with malignant melanomas: different growth rate and different histology. Clin Imaging; 2010 Sep-Oct;34(5):396-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Melanoma / diagnosis. Skin Neoplasms / pathology. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Diagnosis, Differential. Follow-Up Studies. Humans. Lung / radiography. Lung / surgery. Male. Middle Aged


20. Collins AM, Ridgway PF, Killeen RP, Dodd JD, Tolan M: Congenital cystic adenomatoid malformation of the lung: hazards of delayed diagnosis. Respirology; 2009 Sep;14(7):1058-60
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  • [Title] Congenital cystic adenomatoid malformation of the lung: hazards of delayed diagnosis.
  • Lung-sparing surgery, in the form of two segmentectomies and a non-anatomical resection, was performed in order to avoid pneumonectomy.
  • [MeSH-major] Cystic Adenomatoid Malformation of Lung, Congenital / complications. Cystic Adenomatoid Malformation of Lung, Congenital / diagnosis. Delayed Diagnosis
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / etiology. Adult. Humans. Lung / abnormalities. Lung / pathology. Lung / radiography. Lung Neoplasms / etiology. Male. Tomography, X-Ray Computed

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  • (PMID = 19740267.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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21. Ou SH, Zell JA, Ziogas A, Anton-Culver H: Prognostic factors for survival of stage I nonsmall cell lung cancer patients : a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003. Cancer; 2007 Oct 1;110(7):1532-41
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  • [Title] Prognostic factors for survival of stage I nonsmall cell lung cancer patients : a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003.
  • BACKGROUND: Platinum-based adjuvant chemotherapy in randomized trials has failed to provide a survival benefit in patients with resected stage I nonsmall cell lung cancer (NSCLC).
  • RESULTS: Advanced age at diagnosis, male sex, low socioeconomic status (SES), nonsurgical treatment, and poor histologic grade (stage IA NSCLC: hazards ratio [HR], 1.13; 95% confidence interval [95% CI], 1.08-1.19; stage IB NSCLC: HR, 1.11; 95% CI, 1.07-1.16) were associated with increased mortality risk on multivariate analysis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / mortality. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / mortality. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adult. Aged. Asian Americans / statistics & numerical data. California / epidemiology. Carcinoma, Large Cell / mortality. Carcinoma, Large Cell / pathology. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging. Pneumonectomy / methods. Predictive Value of Tests. Prognosis. Proportional Hazards Models. Registries. Risk Assessment. Risk Factors. Survival Rate

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  • (PMID = 17702091.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Okita R, Yamashita M, Nakata M, Teramoto N, Bessho A, Mogami H: Multiple ground-glass opacity in metastasis of malignant melanoma diagnosed by lung biopsy. Ann Thorac Surg; 2005 Jan;79(1):e1-2
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  • [Title] Multiple ground-glass opacity in metastasis of malignant melanoma diagnosed by lung biopsy.
  • Focal ground-glass opacity (GGO) on computed tomography has been reported in several disorders including inflammatory disease and primary neoplastic lesion of the lung.
  • Lung biopsy specimen demonstrated melanoma cells proliferating in a lepidic fashion along the thickened alveolar wall simulating bronchioloalveolar carcinoma.
  • Metastatic lung tumor showing GGO is uncommon.
  • [MeSH-major] Lung Neoplasms / radiography. Lung Neoplasms / secondary. Melanoma / radiography. Melanoma / secondary. Nasal Cavity / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / radiography. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Antineoplastic Agents, Alkylating / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Chemotherapy, Adjuvant. Dacarbazine / therapeutic use. Diagnosis, Differential. Female. Humans. Melanocytes / pathology. Middle Aged. Picibanil / administration & dosage. Tegafur / administration & dosage. Tomography, X-Ray Computed. Uracil / administration & dosage

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  • (PMID = 15620900.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 1548R74NSZ / Tegafur; 39325-01-4 / Picibanil; 56HH86ZVCT / Uracil; 7GR28W0FJI / Dacarbazine
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23. Matsuoka T, Sugi K, Matsuda E, Okabe K, Hirazawa K, Azuma T: [Mycobacterium avium complex (MAC) infection needed differential diagnosis of the recurrence after surgery for double lung cancer; report of a case]. Kyobu Geka; 2007 Dec;60(13):1200-3
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  • [Title] [Mycobacterium avium complex (MAC) infection needed differential diagnosis of the recurrence after surgery for double lung cancer; report of a case].
  • A 62-year-old woman had undergone video-assisted thoracic surgery (VATS) -right upper lobectomy and right S8 segmentectomy for double lung cancers (papillary adenocarcinoma and bronchioloalveoler carcinoma, stage IA).
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adenocarcinoma, Papillary / diagnosis. Adenocarcinoma, Papillary / surgery. Lung Neoplasms / diagnosis. Lung Neoplasms / surgery. Mycobacterium avium-intracellulare Infection / diagnosis. Neoplasms, Multiple Primary. Tuberculosis, Pulmonary / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 18078091.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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24. Izquierdo-Garcia FM, Moreno-Mata N, Herranz-Aladro ML, Cañizares MA, Alvarez-Fernandez E: Lung carcinoma with rhabdoid component. A series of seven cases associated with uncommon types of non-small cell lung carcinomas and alveolar entrapment. Histol Histopathol; 2010 10;25(10):1287-95
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  • [Title] Lung carcinoma with rhabdoid component. A series of seven cases associated with uncommon types of non-small cell lung carcinomas and alveolar entrapment.
  • Rhabdoid tumor, included in the WHO classification among large cell carcinomas of the lung, is an uncommon type of lung carcinoma with poor prognosis.
  • We report a series of 7 cases of lung carcinomas with rhabdoid component in 10% and 80% of the tumor.
  • The associated tumor was adenocarcinoma in 3 cases--one of them with focal micropapillary pattern--large cell carcinoma in 2 cases, squamous cell carcinoma in 1 case and pleomorphic carcinoma in 1 case.
  • Alveolar trapping inside the tumor was present in 3 cases--a phenomenon not well studied in lung carcinomas and also not reported in tumors with rhabdoid component.
  • Five patients died because of the tumor within 2 to 31 months after diagnosis, one of myocardial infarction and only one is alive and disease free 123 months after the diagnosis.
  • In summary, we describe 7 new cases of this uncommon lung tumor with aggressive clinical course, associated with infrequent histological types in nonrhabdoid component and with alveolar trapping, a nondescribed finding.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Large Cell / pathology. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / pathology. Pulmonary Alveoli / pathology. Rhabdoid Tumor / pathology

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  • (PMID = 20712013.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Travis WD, Garg K, Franklin WA, Wistuba II, Sabloff B, Noguchi M, Kakinuma R, Zakowski M, Ginsberg M, Padera R, Jacobson F, Johnson BE, Hirsch F, Brambilla E, Flieder DB, Geisinger KR, Thunnissen F, Kerr K, Yankelevitz D, Franks TJ, Galvin JR, Henderson DW, Nicholson AG, Hasleton PS, Roggli V, Tsao MS, Cappuzzo F, Vazquez M: Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria. J Thorac Oncol; 2006 Nov;1(9 Suppl):S13-9
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  • [Title] Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria.
  • INTRODUCTION: Advances in the pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC) have demonstrated important new prognostic features that have led to changes in classification and diagnostic criteria.
  • METHODS: The literature and a set of cases were reviewed by a pathology/CT review panel of pathologists and radiologists who met during a November 2004 International Association for the Study of Lung Cancer/American Society of Clinical Oncology consensus workshop in New York.
  • The group addressed the question of whether sufficient data exist to modify the 2004 World Health Organization (WHO) classification of adenocarcinoma and BAC to define a "minimally invasive" adenocarcinoma with BAC.
  • The problems of diffuse and/or multicentric BAC and adenocarcinoma were evaluated.
  • Most lung adenocarcinomas, including those with a BAC component, are invasive and consist of a mixture of histologic patterns.
  • Therefore, they are best classified as adenocarcinoma, mixed subtype.
  • The percentage of BAC versus invasive components in lung adenocarcinomas seems to be prognostically important.
  • The diagnosis of BAC requires thorough histologic sampling of the tumor.
  • CONCLUSION: Advances in understanding of the pathology and CT features of BAC and adenocarcinoma have led to important changes in diagnostic criteria and classification of BAC and adenocarcinoma.
  • The 2004 WHO classification of adenocarcinoma is readily applicable to research studies, but attention needs to be placed on the relative proportion of the adenocarcinoma subtypes.
  • More work is needed to determine the most important prognostic pathologic features in lung adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / classification. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / classification. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / classification. Adenocarcinoma / pathology. Adenocarcinoma / radiography. Biopsy, Needle. Cytodiagnosis / methods. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Risk Factors. Sensitivity and Specificity. Tomography, X-Ray Computed. World Health Organization

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  • (PMID = 17409995.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Consensus Development Conference; Journal Article
  • [Publication-country] United States
  • [Number-of-references] 43
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26. Iwanami M, Odaka M, Nakamura T, Hirata K: [Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome associated with anti P/Q-type voltage-gated calcium channel antibody in a patient with primary double lung cancer]. Brain Nerve; 2009 Sep;61(9):1083-7
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  • [Title] [Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome associated with anti P/Q-type voltage-gated calcium channel antibody in a patient with primary double lung cancer].
  • We report the case of a 50-year-old man with paraneoplastic cerebellar degeneration (PCD) and Lambert-Eaton myasthenic syndrome (LEMS) associated with primary double lung cancer.
  • On the basis of the diagnosis of acute cerebelitis, he was given methylprednisolone pulse therapy followed by oral prednisolone, which gradually improved his neurological signs and symptoms.
  • The analysis of the possible etiology suggested that the PCD was induced by lung cancer, which led to ataxia.
  • A chest computed tomography scan revealed mass lesions of irregular shape and unclear margins in the upper lobe of the right lung and a small nodule tumor in the upper lobe of the left lung.
  • We performed transbronchial needle aspiration and detected the bronchioloalveolar carcinoma of the right lung.
  • A diagnosis of double primary lung cancer was made.
  • Physicians need to be aware that patients may develop PCD and LEMS associated with anti-VGCC antibody caused by small cell lung cancer, and a mass survey should be conducted and careful examinations performed.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / immunology. Autoantibodies / immunology. Calcium Channels, P-Type / immunology. Calcium Channels, Q-Type / immunology. Lambert-Eaton Myasthenic Syndrome / etiology. Lung Neoplasms / immunology. Neoplasms, Multiple Primary. Paraneoplastic Cerebellar Degeneration / etiology


27. Fukui T, Sakakura N, Mori S, Hatooka S, Shinoda M, Yatabe Y, Mitsudomi T: Controversy about small peripheral lung adenocarcinomas: how should we manage them? J Thorac Oncol; 2007 Jun;2(6):546-52
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  • [Title] Controversy about small peripheral lung adenocarcinomas: how should we manage them?
  • In recent years, the clinical use of high-resolution computed tomography has greatly advanced the diagnosis of small lesions of the peripheral lung.
  • The noninvasive bronchioloalveolar carcinoma component with a replacement growth pattern of alveolar lining cells manifests as ground-glass opacity.
  • Bronchioloalveolar carcinoma is classified as a subset of lung adenocarcinoma, but has a distinct clinical presentation, tumor biology, and favorable prognosis.
  • Most small peripheral lung lesions including bronchioloalveolar carcinoma putatively originate from the peripheral airway epithelium, in which the epidermal growth factor receptor gene is frequently mutated.
  • As with other subsets of non-small cell lung cancer, surgical resection is a potentially curative treatment.
  • Although several authors in Japan suggest the suitability of limited resection including segmentectomy and wedge resection without any nodal dissections for these small lung adenocarcinomas, this procedure should be validated in future clinical trials.
  • [MeSH-major] Adenocarcinoma / therapy. Lung Neoplasms / therapy

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  • [ErratumIn] J Thorac Oncol. 2007 Aug;2(8):734.
  • [ErratumIn] J Thorac Oncol. 2008 Mar;3(3):322
  • (PMID = 17545852.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 59
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28. Hsu LH, Chu NM, Liu CC, Tsai SY, You DL, Ko JS, Lu MC, Feng AC: Sex-associated differences in non-small cell lung cancer in the new era: is gender an independent prognostic factor? Lung Cancer; 2009 Nov;66(2):262-7
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  • [Title] Sex-associated differences in non-small cell lung cancer in the new era: is gender an independent prognostic factor?
  • BACKGROUND: Women with non-small cell lung cancer (NSCLC) appear to have better survival.
  • Females were younger (median age: 59.5 years vs. 65.0 years; P<0.001) and more likely to have adenocarcinoma (81% vs. 60.5%; P<0.001).
  • Patients with earlier stage, younger patients, never-smokers and females had better overall survival in univariate analyses and no significant survival difference was noted between adenocarcinoma and squamous cell carcinoma.
  • Subgroup analyses revealed the survival of never-smoker males with adenocarcinoma was similar to that of females.
  • Never-smokers with adenocarcinoma should be given special attention regardless of sex as they imply better survival with different treatment outcomes.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Lung Neoplasms / mortality
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / mortality. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Aged. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / mortality. Female. Humans. Male. Middle Aged. Prognosis. Sex Factors. Smoking


29. Mazziotti S, Celona A, Gaeta M: Usefulness of heavily T2-weighted magnetic resonance imaging in the diagnosis of alveolar lung metastases from pancreas mucinous adenocarcinoma. J Thorac Imaging; 2008 Feb;23(1):44-6
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  • [Title] Usefulness of heavily T2-weighted magnetic resonance imaging in the diagnosis of alveolar lung metastases from pancreas mucinous adenocarcinoma.
  • We report the case of a patient with pancreatic adenocarcinoma and mucinous air-space metastases, in which the diagnosis was suspected at magnetic resonance using heavily T2-weighted images obtained with magnetic resonance hydrographic sequences.
  • [MeSH-major] Adenocarcinoma, Mucinous / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Magnetic Resonance Imaging / methods. Pancreatic Neoplasms / pathology. Pulmonary Alveoli / pathology
  • [MeSH-minor] Contrast Media / administration & dosage. Diagnosis, Differential. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 18347520.001).
  • [ISSN] 0883-5993
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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30. Gandara DR, Aberle D, Lau D, Jett J, Akhurst T, Heelan R, Mulshine J, Berg C, Patz EF Jr: Radiographic imaging of bronchioloalveolar carcinoma: screening, patterns of presentation and response assessment. J Thorac Oncol; 2006 Nov;1(9 Suppl):S20-6
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  • Bronchioloalveolar carcinoma (BAC) is a previously uncommon subset of adenocarcinoma with unique epidemiology, pathology, radiographic presentation, clinical features, and natural history compared with other non-small cell lung cancer (NSCLC) subtypes.
  • However, in a subset of patients, rapid growth and death from bilateral diffuse consolidative disease occurs within months of diagnosis or recurrence.
  • The rising incidence of BAC is also reflected in recent lung cancer screening studies employing helical computed tomography (CT), where the differential diagnosis of GGOs includes not only BAC and overt adenocarcinoma, but inflammatory disease, focal fibrosis, and atypical adenomatous hyperplasia.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Carcinoma, Non-Small-Cell Lung / radiography. Lung Neoplasms / radiography. Neoplasm Recurrence, Local / radiography. Tomography, Spiral Computed
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Mass Screening / methods. Neoplasm Staging. Pneumonectomy / methods. Positron-Emission Tomography. Sensitivity and Specificity. Treatment Outcome

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  • [ErratumIn] J Thorac Oncol. 2007 Jan;2(1):11. Heelan, Robert [added]
  • (PMID = 17409997.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 65
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31. Christiani DC, Pao W, DeMartini JC, Linnoila RI, Malkinson AM, Onn A, Politi KA, Sharp M, Wong KK: BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models. J Thorac Oncol; 2006 Nov;1(9 Suppl):S2-7
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  • "Pure" BAC, characterized by a bronchioloalveolar growth pattern and no evidence of stromal, vascular, or pleural invasion, represents only 2 to 6% of non-small cell lung cancer (NSCLC) cases, but up to 20% of NSCLC cases may contain elements of BAC.
  • However, because BAC appears to behave clinically differently from adenocarcinoma, a better understanding of this disease entity is imperative.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / epidemiology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / epidemiology. Lung Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenocarcinoma / pathology. Adenocarcinoma / physiopathology. Animals. Biopsy, Needle. Diagnosis, Differential. Disease Models, Animal. Female. Humans. Immunohistochemistry. Male. Mice. Mice, Nude. Mice, Transgenic. Neoplasm Staging. Prevalence. Prognosis. Risk Assessment. Sheep

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  • [ErratumIn] J Thorac Oncol. 2007 Jan;2(1):11. Kim, Kwok [corrected to Wong, Kwok-Kin]
  • (PMID = 17409996.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 074386; United States / NCI NIH HHS / CA / CA 092824; United States / NCI NIH HHS / CA / CA 0940578; United States / NCI NIH HHS / CA / CA 59116; United States / NIA NIH HHS / AG / K08AG 2400401
  • [Publication-type] Consensus Development Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Number-of-references] 79
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32. Parshin VD, Grigor'eva SP, Mirzoian OS, Fedorov DN: [Surgical treatment of bronchiolo-alveolar cancer]. Khirurgiia (Mosk); 2009;(12):4-12
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  • [Title] [Surgical treatment of bronchiolo-alveolar cancer].
  • Bronchioloalveolar cancer (BAC) belongs to a high- grade differentiated lung adenocarcinoma, localizes in peripheral parts of the lung and demonstrates an intraalveolar growth.
  • It comprised 0,5% of the whole amount of patients operated on lung cancer.
  • Long-term treatment results are somewhat better then of other forms of non-small cell carcinoma of lung: of 21 radically operated patients, 11 are alive.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 20037505.001).
  • [ISSN] 0023-1207
  • [Journal-full-title] Khirurgiia
  • [ISO-abbreviation] Khirurgiia (Mosk)
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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33. Fujimoto K: Usefulness of contrast-enhanced magnetic resonance imaging for evaluating solitary pulmonary nodules. Cancer Imaging; 2008;8:36-44
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  • [MeSH-major] Image Enhancement. Lung Neoplasms / diagnosis. Magnetic Resonance Imaging / methods. Solitary Pulmonary Nodule / diagnosis
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Carcinoma, Non-Small-Cell Lung / metabolism. Contrast Media. Diagnosis, Differential. Gadolinium. Hamartoma / diagnosis. Humans. Lung Diseases / diagnosis. Pneumonia, Pneumococcal / diagnosis. Positron-Emission Tomography. Prognosis. Sensitivity and Specificity. Tomography, X-Ray Computed. Tuberculoma / diagnosis. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 18331971.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Vascular Endothelial Growth Factor A; AU0V1LM3JT / Gadolinium
  • [Number-of-references] 41
  • [Other-IDs] NLM/ PMC2267694
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34. Que CL, Zhang PJ, Wang WH, He B, Yin HF, Wang RG: [An analysis of the clinical and radiological features of bronchioloalveolar carcinoma]. Zhonghua Jie He He Hu Xi Za Zhi; 2006 Oct;29(10):662-4
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  • METHODS: Data of 1 050 inpatients of lung cancer, including 50 cases of pathology-proven bronchioloalveolar carcinoma, diagnosed in our hospital between 1993 and 2003, were retrospectively reviewed.
  • CONCLUSIONS: Bronchioloalveolar carcinoma accounted for 4.76% of lung carcinoma in our series, with a female predominance.
  • The characteristics of HRCT findings are very helpful in its diagnosis and differential diagnosis.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • (PMID = 17129492.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. Suau F, Cottin V, Archer F, Croze S, Chastang J, Cordier G, Thivolet-Béjui F, Mornex JF, Leroux C: Telomerase activation in a model of lung adenocarcinoma. Eur Respir J; 2006 Jun;27(6):1175-82
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  • [Title] Telomerase activation in a model of lung adenocarcinoma.
  • Ovine pulmonary adenocarcinoma (OPA) is a lung cancer strikingly similar to the pneumonic-type mixed invasive adenocarcinoma with a predominant bronchioloalveolar component in humans.
  • Lung tissues were collected from sheep with a histopathological diagnosis of OPA or controls.
  • Epithelial cell cultures were derived in vitro from lung tissues.
  • Telomerase activity was significantly higher in OPA lung tissues compared to control lung tissues.
  • Telomerase activation takes place in ovine pulmonary adenocarcinoma tumour cells and may be partly attributable to Akt activation.
  • Telomerase may inhibit cellular senescence and contribute to the accumulation of tumour cells in mixed adenocarcinoma with a bronchioloalveolar component.
  • [MeSH-major] Adenocarcinoma / genetics. Adenocarcinoma, Bronchiolo-Alveolar / genetics. Disease Models, Animal. Jaagsiekte sheep retrovirus / genetics. Lung Neoplasms / genetics. Pulmonary Adenomatosis, Ovine / genetics. Telomerase / genetics
  • [MeSH-minor] Animals. Cell Aging / genetics. Cell Division / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Enzyme Activation / genetics. Gene Expression Regulation / genetics. Humans. Lung / pathology. Proto-Oncogene Proteins c-akt / genetics. Pulmonary Alveoli / pathology. Sheep. Signal Transduction / genetics. Tumor Cells, Cultured / pathology

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  • [CommentIn] Eur Respir J. 2006 Jun;27(6):1079-81 [16772385.001]
  • (PMID = 16455826.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.7.49 / Telomerase
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36. Planque C, Li L, Zheng Y, Soosaipillai A, Reckamp K, Chia D, Diamandis EP, Goodglick L: A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. Clin Cancer Res; 2008 Mar 1;14(5):1355-62
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  • [Title] A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma.
  • We have previously shown that the expression of several tissue kallikreins is significantly altered at the transcriptional level in lung cancer.
  • Here, we examined the clinical value of 11 members of the tissue kallikrein family as potential biomarkers for lung cancer diagnosis.
  • EXPERIMENTAL DESIGN: Serum specimens from 51 patients with non-small cell lung cancer (NSCLC) and from 50 healthy volunteers were collected.
  • CONCLUSIONS: We propose a multiparametric panel of kallikrein markers for lung cancer diagnosis with relatively good accuracy.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Non-Small-Cell Lung / blood. Lung Neoplasms / blood. Tissue Kallikreins / blood
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / blood. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adult. Carcinoma, Large Cell / blood. Carcinoma, Large Cell / pathology. Case-Control Studies. Enzyme-Linked Immunosorbent Assay. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / blood. Neoplasm Recurrence, Local / pathology. ROC Curve

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  • (PMID = 18316555.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-86366; United States / NCI NIH HHS / CA / P50-CA90388
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.35 / Tissue Kallikreins
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37. Yoshida J, Ishii G, Yokose T, Aokage K, Hishida T, Nishimura M, Onuki T, Noguchi M, Nagai K: Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients. J Thorac Oncol; 2010 Apr;5(4):546-50
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  • [Title] Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Glass / chemistry. Lung Neoplasms / diagnosis. Lung Neoplasms / surgery
  • [MeSH-minor] Aged. Biomarkers, Tumor / genetics. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Mutation / genetics. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neoplasm Staging. Receptor, Epidermal Growth Factor / genetics. Survival Rate. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20357619.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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38. Rusch VW, Tsuchiya R, Tsuboi M, Pass HI, Grunenwald D, Goldstraw P: Surgery for bronchioloalveolar carcinoma and "very early" adenocarcinoma: an evolving standard of care? J Thorac Oncol; 2006 Nov;1(9 Suppl):S27-31
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  • [Title] Surgery for bronchioloalveolar carcinoma and "very early" adenocarcinoma: an evolving standard of care?
  • Lobectomy and mediastinal lymph node dissection is the standard surgical management of early stage non-small cell lung cancer (NSCLC) because more limited resections have been associated with a higher risk of local recurrence.
  • Nevertheless, recent lung cancer screening studies have led to the detection of an increasing number of "very early" NSCLC (defined as less than 2 cm in size) and of good-prognosis histologic subtypes, bronchioloalveolar carcinoma (BAC), and adenocarcinoma (AC), mixed subtypes that are potentially appropriate for sublobar resection.
  • Very limited experience suggests that lung transplantation leads to prolonged survival in highly selected patients with this histologic subtype.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / mortality. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / mortality. Lung Neoplasms / surgery. Lymph Nodes / pathology. Pneumonectomy / methods
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adenocarcinoma / surgery. Clinical Trials, Phase III as Topic. Early Diagnosis. Female. Humans. Immunohistochemistry. Lymph Node Excision / methods. Male. Mediastinum. Neoplasm Invasiveness / pathology. Neoplasm Staging. Prognosis. Risk Assessment. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 17409998.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 46
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39. McGlothlin JR, Gao L, Lavoie T, Simon BA, Easley RB, Ma SF, Rumala BB, Garcia JG, Ye SQ: Molecular cloning and characterization of canine pre-B-cell colony-enhancing factor. Biochem Genet; 2005 Apr;43(3-4):127-41
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  • During our previous attempt to search for the candidate genes to acute lung injury (ALI), we unexpectedly identified PBEF as the most highly upregulated gene in a canine model of ALI by crosshybridizing canine lung cRNA to the Affymetrix human gene chip HG-U133A.
  • Canine PBEF protein was successfully expressed both by in vitro transcription coupled with translation in a cell-free system and by transfection of canine PBEF cDNA into the human lung type II alveolar adenocarcinoma cell line A549.
  • RT-PCR assay indicates that canine PBEF is expressed in canine lung, brain, heart, liver, spleen, kidney, pancreas, and muscle, with liver showing the highest expression,followed by muscle.
  • [MeSH-minor] Amino Acid Sequence. Animals. Biomarkers. Cell Line. Cloning, Molecular. Dogs. Endothelium, Vascular / cytology. Gene Expression. Humans. Lung. Male. Mice. Molecular Sequence Data. Nicotinamide Phosphoribosyltransferase. Rats. Recombinant Proteins / biosynthesis. Respiratory Distress Syndrome, Adult / diagnosis. Respiratory Distress Syndrome, Adult / genetics. Sequence Alignment. Tissue Distribution

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  • (PMID = 15934174.001).
  • [ISSN] 0006-2928
  • [Journal-full-title] Biochemical genetics
  • [ISO-abbreviation] Biochem. Genet.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL58504; United States / NHLBI NIH HHS / HL / U01HL66583
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cytokines; 0 / DNA, Complementary; 0 / Recombinant Proteins; EC 2.4.2.12 / Nicotinamide Phosphoribosyltransferase; EC 2.4.2.12 / nicotinamide phosphoribosyltransferase, human
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40. Harada T, Sukoh N, Hakuma N, Kamimura A, Ito K, Okamoto K: Pulmonary blastoma within bronchioloalveolar cell carcinoma. Respirology; 2006 May;11(3):339-42
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  • Pulmonary blastoma is a rare tumour of the lung composed of epithelial and mesenchymal elements that morphologically resemble the embryonal structure of the lung.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary. Pulmonary Blastoma / diagnosis
  • [MeSH-minor] Aged. Biopsy. Diagnosis, Differential. Humans. Male. Pneumonectomy. Tomography, X-Ray Computed

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  • (PMID = 16635096.001).
  • [ISSN] 1323-7799
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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41. Laskin JJ, Sandler AB, Johnson DH: Redefining bronchioloalveolar carcinoma. Semin Oncol; 2005 Jun;32(3):329-35
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  • Bronchioloalveolar carcinoma (BAC) is a subtype of non-small cell lung cancer (NSCLC) with distinct clinical and pathologic features.
  • Although BAC appears to be on a pathologic continuum with adenocarcinoma, the most recent World Health Organization (WHO) classification system has set stringent criteria for the diagnosis.
  • Though malignant, these cancers tend to be peripheral and grow in a lepedic fashion along the alveolar septae without parenchymal invasion.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar. Lung Neoplasms

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  • (PMID = 15988687.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 49
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42. Chandan VS, Truong LD, Khurana KK: The utility of B72.3, carcinoembryonic antigen, and Leu M-1 in cell blocks: an adjunct to fine-needle aspiration diagnosis of bronchioloalveolar carcinoma of the lung. Cancer; 2005 Aug 25;105(4):246-52
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  • [Title] The utility of B72.3, carcinoembryonic antigen, and Leu M-1 in cell blocks: an adjunct to fine-needle aspiration diagnosis of bronchioloalveolar carcinoma of the lung.
  • BACKGROUND: The distinction of bronchioloalveolar carcinoma (BAC) from atypical adenomatous hyperplasia (AAH) or reactive alveolar cell hyperplasia (RAH) can be difficult on aspiration cytology, even when cell block preparations are available.
  • METHODS: Immunostains for B72.3, CEA, and Leu M-1 were performed on cell block sections from 11 lung lesions that were diagnosed cytologically as BAC (6 lesions) and "atypical cells, cannot exclude BAC" (5 lesions).
  • RESULTS: Among the six lesions that had an unequivocal cytologic diagnosis of BAC, all sections were positive for two of three immunostains.
  • All 10 lesions that had a histologic diagnosis of AAH and 8 lesions that had a histologic diagnosis RAH were negative for B72.3, CEA, and Leu M-1.
  • CONCLUSIONS: Positive staining for at least 2 immunostains among B72.3, CEA, and Leu M-1 provided strong supportive evidence for the diagnosis of BAC, and a negative result for all 3 immunostains was helpful in excluding BAC and in differentiating BAC from AAH and RAH.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Antibodies, Neoplasm / metabolism. Antigens, CD15 / metabolism. Biomarkers, Tumor / metabolism. Carcinoembryonic Antigen / metabolism. Lung Neoplasms / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Diagnosis, Differential. Humans

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  • [Copyright] Copyright (c) 2005 American Cancer Society.
  • (PMID = 15971208.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, CD15; 0 / B72.3 antibody; 0 / Biomarkers, Tumor; 0 / Carcinoembryonic Antigen
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43. Steinfort D, Irving L: Use of fluoroscopy during endobronchial ultrasonography for transbronchial lung biopsies of peripheral lung lesions. J Thorac Oncol; 2008 Jun;3(6):685-6
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  • [Title] Use of fluoroscopy during endobronchial ultrasonography for transbronchial lung biopsies of peripheral lung lesions.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Biopsy / methods. Endosonography / methods. Fluoroscopy / methods. Lung Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged

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  • (PMID = 18520817.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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44. Félix L, Lantuejoul S, Jankowski A, Ferretti G: [Localized pure or mixed ground-glass lung opacities]. J Radiol; 2009 Nov;90(11 Pt 2):1869-92
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  • [Title] [Localized pure or mixed ground-glass lung opacities].
  • Localized ground-glass opacities (GGOs) have been recently individualized and account for between 2.9% and 19% of all pulmonary nodules detected in high-risk patients included in CT screening series for lung cancer.
  • These opacities, nodular, lobular or flat, correspond to benign lesions (localised infectious and inflammatory diseases, focal interstitial fibrosis, and atypical alveolar hyperplasia) or malignant lesions (bronchioloalveolar carcinoma, early-stage adenocarcinoma and sometimes metastases).
  • [MeSH-major] Adenocarcinoma / radiography. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Radiography, Thoracic / methods. Solitary Pulmonary Nodule / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Algorithms. Biopsy. Clinical Trials as Topic. Diagnosis, Differential. Female. Humans. Hyperplasia. Lung / pathology. Middle Aged. Neoplasm Staging. Prognosis. Pulmonary Alveoli / pathology. Risk Factors. Smoking / adverse effects

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  • (PMID = 19953078.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 101
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45. Diederich S: Pulmonary nodules: do we need a separate algorithm for non-solid lesions? Cancer Imaging; 2009;9 Spec No A:S126-8
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  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Algorithms. Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenoma / radiography. Adult. Aged. Follow-Up Studies. Humans. Hyperplasia. Incidental Findings. Mass Screening. Middle Aged. Positron-Emission Tomography. Precancerous Conditions / diagnosis. Precancerous Conditions / radiography

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  • [Cites] Am J Respir Crit Care Med. 2002 Feb 15;165(4):508-13 [11850344.001]
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  • (PMID = 19965304.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 14
  • [Other-IDs] NLM/ PMC2797465
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46. Elgoweini M, May C, Devgun MS, Howatson SR, Gupta G: Secondary cryofibrinogenaemia due to bronchial adenocarcinoma presenting as cutaneous necrosis. Clin Exp Dermatol; 2007 May;32(3):343-4
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  • [Title] Secondary cryofibrinogenaemia due to bronchial adenocarcinoma presenting as cutaneous necrosis.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / complications. Cryoglobulinemia / etiology. Fibrinogens, Abnormal. Lung Neoplasms / complications. Skin / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Necrosis

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  • (PMID = 17397363.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fibrinogens, Abnormal
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47. Infante M, Lutman RF, Imparato S, Di Rocco M, Ceresoli GL, Torri V, Morenghi E, Minuti F, Cavuto S, Bottoni E, Inzirillo F, Cariboni U, Errico V, Incarbone MA, Ferraroli G, Brambilla G, Alloisio M, Ravasi G: Differential diagnosis and management of focal ground-glass opacities. Eur Respir J; 2009 Apr;33(4):821-7
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  • [Title] Differential diagnosis and management of focal ground-glass opacities.
  • Of these, 11 patients were diagnosed with benign GGOs, 19 patients had lung cancer and 10 were undetermined.
  • Overall, 18 patients underwent surgery for lung cancer.
  • The stepwise approach adopted in the present study increased the diagnostic specificity and reduced time to definitive diagnosis.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / radiography. Lung Neoplasms / surgery
  • [MeSH-minor] Aged. Anti-Bacterial Agents / therapeutic use. Biopsy. Diagnosis, Differential. Female. Humans. Male. Tomography, X-Ray Computed

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  • [CommentIn] Eur Respir J. 2009 Oct;34(4):1008-9; author reply 1009-10 [19797677.001]
  • (PMID = 19047318.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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48. Miyata Y: [Q & A in imaging diagnosis. Ground-glass opacity observed by thoracic CT]. Kyobu Geka; 2010 Feb;63(2):146-51
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  • [Title] [Q & A in imaging diagnosis. Ground-glass opacity observed by thoracic CT].
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / surgery

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  • (PMID = 20329360.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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49. Ou SH, Zell JA: Carcinoma NOS is a common histologic diagnosis and is increasing in proportion among non-small cell lung cancer histologies. J Thorac Oncol; 2009 Oct;4(10):1202-11
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  • [Title] Carcinoma NOS is a common histologic diagnosis and is increasing in proportion among non-small cell lung cancer histologies.
  • BACKGROUND: Recent clinical trials have demonstrated differential survival benefit from chemotherapy regimens according to non-small cell lung cancer (NSCLC) histology.
  • The very elderly (80+ years) had the highest proportion of carcinoma NOS and cytologically diagnosed NSCLC regardless of period of diagnosis.
  • Cox proportional hazards regression analysis applied to stage 4 NSCLC patients indicated carcinoma NOS (vs. adenocarcinoma; hazard ratio 1.061, 95% confidence interval 1.039-1.083, p < 0.0001) and cytologically diagnosed NSCLC (versus histologically diagnosed NSCLC, hazard ratio 1.043, 95% confidence interval 1.024-1.062, p < 0.0001) were independent unfavorable prognostic factors for OS.
  • CONCLUSIONS: Carcinoma NOS was a common histologic diagnosis, had been increasing over time among NSCLC, and carried an independent unfavorable prognosis among stage 4 NSCLC patients.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / classification. Adenocarcinoma / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / classification. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Large Cell / classification. Carcinoma, Large Cell / diagnosis. Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / diagnosis. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. SEER Program. Survival Rate. Young Adult

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  • (PMID = 19701111.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Grant] United States / NCCDPHP CDC HHS / DP / 1U58DP00807-01
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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50. Gao YS, Zhang DC, He J, Sun KL, Zhang DW, Zhang RG: [Diagnosis and surgical treatment for stage I non-small-cell lung cancer]. Zhonghua Zhong Liu Za Zhi; 2005 Jan;27(1):52-5
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  • [Title] [Diagnosis and surgical treatment for stage I non-small-cell lung cancer].
  • OBJECTIVE: To evaluate the results of surgery and the diagnosis of stage I non-small-cell lung cancer (NSCLC).
  • The 5-year survival rates for patients with squamous-cell carcinoma, adenocarcinoma, adenosquamous and alveolar-cell carcinoma were 73.3%, 55.3%, 52.2%, 71.7%, respectively.
  • The 1-, 3-, 5-year survival rates for T1N0 were 95.0%, 83.2%, 74.3% whereas those of T2N0 lung lesions were 90.8%, 75.9%, 59.9% (P < 0.05).
  • CONCLUSION: The 5-year survival rate of pathologic stage I non-small-cell lung cancer is 66.1%.
  • The outcome of patients with squamous-cell carcinoma (73.3%) is similar to that of alveolar-cell carcinoma (71.7%) which, however, is better than that of adenocarcinoma (55.3%) or adenosquamouscarcinoma (52.5%).
  • Regular lobectomy plus radical mediastinal lymph node dissection is the appropriate management for stage I non-small-cell lung cancer.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Lymph Node Excision. Pneumonectomy / methods

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  • (PMID = 15771801.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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51. Hennink S, Wouters MW, Klomp HM, Baas P: Necrotizing pneumonitis caused by postoperative pulmonary torsion. Interact Cardiovasc Thorac Surg; 2008 Feb;7(1):144-5
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  • A review of the literature shows that a delay in diagnosis and treatment of this rare complication can have catastrophic consequences.
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Bronchoscopy. Female. Follow-Up Studies. Humans. Lung Neoplasms / surgery. Middle Aged. Necrosis / diagnosis. Necrosis / etiology. Necrosis / surgery. Reoperation. Tomography, X-Ray Computed. Torsion Abnormality / complications. Torsion Abnormality / diagnosis. Torsion Abnormality / surgery

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  • (PMID = 18042566.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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52. Moon H, Park SJ, Kim SR, Park HS, Lee YC: Benign intercostal schwannoma mimicking a solitary metastasis from lung cancer. Thorax; 2010 Aug;65(8):753-4
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  • [Title] Benign intercostal schwannoma mimicking a solitary metastasis from lung cancer.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / secondary. Intercostal Nerves. Lung Neoplasms / diagnosis. Neoplasms, Multiple Primary / diagnosis. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20530120.001).
  • [ISSN] 1468-3296
  • [Journal-full-title] Thorax
  • [ISO-abbreviation] Thorax
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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53. Feng FY, Zhang DC, Liu XY, Wang YG, Mao YS: [Surgical treatment and prognosis of synchronous double primary lung cancer: a report of 31 cases]. Ai Zheng; 2005 Feb;24(2):215-8
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  • [Title] [Surgical treatment and prognosis of synchronous double primary lung cancer: a report of 31 cases].
  • BACKGROUND & OBJECTIVE: The idea of double primary lung cancer (DPLC) has been generally accepted.
  • RESULTS: The 31 patients with synchronous DPLC accounted for 0.67% of all 4 649 patients operated for primary lung cancer in our department during the same period.
  • [MeSH-major] Adenocarcinoma / surgery. Carcinoma, Squamous Cell / surgery. Lung Neoplasms / surgery. Neoplasms, Multiple Primary / surgery. Pneumonectomy / methods
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Aged. Aged, 80 and over. Carcinoid Tumor / diagnosis. Carcinoid Tumor / surgery. Female. Humans. Male. Middle Aged. Prognosis. Pulmonary Atelectasis / etiology. Respiratory Insufficiency / etiology. Retrospective Studies. Survival Rate

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  • (PMID = 15694037.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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54. Lee P, de Bree R, Brokx HA, Leemans CR, Postmus PE, Sutedja TG: Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy? Lung Cancer; 2008 Dec;62(3):309-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary lung cancer after treatment of head and neck cancer without lymph node metastasis: is there a role for autofluorescence bronchoscopy?
  • OBJECTIVES: To determine if autofluorescence bronchoscopy (AF) played a role in the detection of second primary lung cancer (SPLC), and impact of SPLC on survival of patients with HNC and no cervical lymph node metastasis (N0).
  • METHODS: Patients with HNC(N0) referred for symptoms and/or radiology suspicious for lung cancer were assessed with AF.
  • Median age was 70 years, all were current or former smokers of 35 pack years, and 25 had chronic obstructive lung disease.
  • Forty-two SPLC were found; 12 (29%) affected the tracheobronchial tree and 30 (71%) involved the lung parenchyma.
  • Five radiographically occult lung cancers detected by AF were successfully treated with endobronchial therapy.
  • Lung cancer mortality was 24%.
  • Close surveillance with AF and CT for SPLC combined with aggressive treatment of early stage lung cancer might be a strategy to improve outcome.
  • [MeSH-major] Bronchoscopy. Carcinoma, Non-Small-Cell Lung / diagnosis. Head and Neck Neoplasms / pathology. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adult. Aged. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / drug therapy. Female. Fluorescence. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / drug therapy. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Prospective Studies. Small Cell Lung Carcinoma / diagnosis. Small Cell Lung Carcinoma / drug therapy. Smoking. Survival Rate. Treatment Outcome


55. Metzelder SK, Reinke C, Walthers EM, Barth P, Vogelmeier C, Neubauer A, Bals R: ["Malignant" ARDS]. Internist (Berl); 2009 Oct;50(10):1272, 1274-7
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  • In the second patient, lung histology revealed an adenocarcinoma of the lung.
  • Beside solid cancers and lymphomas, acute and progressive forms of inflammatory, parenchymal lung diseases (such as acute interstitial pneumonitis, acute eosinophilic pneumonia, diffuse alveolar hemorrhagia, and acute hypersensitivity pneumonitis) can manifest with this picture.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Lung Diseases, Interstitial / complications. Lung Diseases, Interstitial / diagnosis. Lung Neoplasms / complications. Lung Neoplasms / diagnosis. Respiratory Distress Syndrome, Adult / diagnosis. Respiratory Distress Syndrome, Adult / etiology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Cites] J Crit Care. 1994 Mar;9(1):72-81 [8199655.001]
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  • (PMID = 19562262.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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56. Heresi GA, Mazzone PJ: Multiple pulmonary nodules in an elderly woman. J Thorac Oncol; 2006 Jul;1(6):580-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Radiography, Thoracic. Solitary Pulmonary Nodule / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Biopsy, Needle. Bronchoscopy / methods. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Sensitivity and Specificity

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  • (PMID = 17409921.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Bearz A, Talamini R, Vaccher E, Spina M, Simonelli C, Steffan A, Berretta M, Chimienti E, Tirelli U: MUC-1 (CA 15-3 antigen) as a highly reliable predictor of response to EGFR inhibitors in patients with bronchioloalveolar carcinoma: an experience on 26 patients. Int J Biol Markers; 2007 Oct-Dec;22(4):307-11
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  • BACKGROUND: Bronchioloalveolar carcinoma (BAC) is a histological subtype of non-small cell lung cancer (NSCLC), particularly of adenocarcinoma.
  • No tumor marker has been validated in the diagnosis and follow-up of lung cancer, in particular to predict the outcome of treatment with EGFR inhibitors.
  • PURPOSE: As CA 15-3 antigen serum levels are reported to be pathologically abnormal in adenocarcinoma of the lung, we chose this tumor marker to monitor treatment with EGFR inhibitors of patients affected by adenocarcinoma with BAC features or pure BAC.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / metabolism. Biomarkers, Tumor. Carcinoma, Non-Small-Cell Lung / metabolism. Gene Expression Regulation, Neoplastic. Lung Neoplasms / metabolism. Mucin-1 / biosynthesis. Mucin-1 / physiology. Receptor, Epidermal Growth Factor / antagonists & inhibitors


58. Goyal A, Chen S: Bronchioloalveolar carcinoma is really carcinoma in situ. Arch Pathol Lab Med; 2008 Oct;132(10):1548
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Carcinoma in Situ / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans. World Health Organization

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  • [CommentOn] Arch Pathol Lab Med. 2007 Jul;131(7):1027-32 [17616987.001]
  • (PMID = 18834206.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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59. Sugita M, Sagawa M, Ueda Y, Higashi K, Sakuma T: Localized bronchioloalveolar carcinoma with small foci of active fibroblastic proliferation. A report of 2 cases. Respiration; 2006;73(5):694-7
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  • Based on these observations, LBAC cases have been considered candidates for limited lung resection without lymph node dissection.
  • However, this surgical option requires careful validation, and an accurate diagnosis is indispensable.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Cell Proliferation. Fibroblasts / pathology. Lung Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Positron-Emission Tomography. Preoperative Care. Prognosis. Tomography, X-Ray Computed

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  • (PMID = 16043954.001).
  • [ISSN] 0025-7931
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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60. Shaw JP, Bejarano PA, Thurer RJ: Pseudocavitating bronchioloalveolar carcinoma followed over a decade. Ann Thorac Surg; 2008 Apr;85(4):1432-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Pneumonia / diagnosis
  • [MeSH-minor] Adult. Biopsy, Needle. Bronchoscopy / methods. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Neoplasm Staging. Pneumonectomy / methods. Risk Factors. Thoracotomy / methods. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18355545.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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61. Liu S, Cheng H, Yao S, Wang C, Han G, Li X, Liu C: The clinical application value of PET/CT in adenocarcinoma with bronchioloalveolar carcinoma features. Ann Nucl Med; 2010 Aug;24(7):541-7
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  • [Title] The clinical application value of PET/CT in adenocarcinoma with bronchioloalveolar carcinoma features.
  • OBJECTIVE: The goal of our study was to demonstrate the clinical usefulness of positron emission tomography/computed tomography (PET/CT) for adenocarcinoma with bronchioloalveolar carcinoma (BAC) features, through evaluating the relationship between the intrathoracic lymph node metastases and maximum standardized uptake value (SUVmax), tumor size of the primary tumor and the ratio of BAC component and analysing the correlation of SUVmax, tumor size and the ratio of BAC component.
  • Forty-five patients with focal peripheral lung adenocarcinoma with BAC features were included in this study and underwent the PET/CT scan.
  • The diagnosis of the lesion was made by surgical histopathology.
  • CONCLUSIONS: PET/CT would be clinically useful for adenocarcinoma with BAC features, because SUVmax obtained by PET/CT can predict the incidence of intrathoracic lymph node metastases at preoperative stages and even for inoperable patients.
  • [MeSH-major] Adenocarcinoma / complications. Adenocarcinoma / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / complications. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 20614257.001).
  • [ISSN] 1864-6433
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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62. Xu X, Chung JH, Jheon S, Sung SW, Lee CT, Lee JH, Choe G: The accuracy of frozen section diagnosis of pulmonary nodules: evaluation of inflation method during intraoperative pathology consultation with cryosection. J Thorac Oncol; 2010 Jan;5(1):39-44
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  • [Title] The accuracy of frozen section diagnosis of pulmonary nodules: evaluation of inflation method during intraoperative pathology consultation with cryosection.
  • INTRODUCTION: Intraoperative frozen section diagnosis (FSD) is a very important pathologic examination that can determine the extent of the subsequent surgical procedure.
  • The frozen section quality of lung tissue was excellent after inflation with diluted embedding medium.
  • Inflated lung specimens harboring minute lesion displayed distinct gross appearance, which could not be palpated.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Frozen Sections / methods. Hyperplasia / diagnosis. Lung Neoplasms / diagnosis. Precancerous Conditions / diagnosis. Solitary Pulmonary Nodule / diagnosis

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  • (PMID = 19934776.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Hautmann H, Henke MO, Bitterling H: High diagnostic yield from transbronchial biopsy of solitary pulmonary nodules using low-dose CT-guidance. Respirology; 2010 May;15(4):677-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Lung Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Aged. Bronchoscopy / methods. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Cohort Studies. Female. Fluoroscopy. Humans. Male. Middle Aged. Radiation Dosage. Small Cell Lung Carcinoma / diagnosis. Small Cell Lung Carcinoma / pathology

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  • (PMID = 20409025.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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64. De Filippo M, Onniboni M, Rusca M, Carbognani P, Ferrari L, Guazzi A, Casalini A, Verardo E, Cataldi V, Tiseo M, Sverzellati N, Chiari G, Rabaiotti E, Corsi A, Cacciani G, Sommario M, Ardizzoni A, Zompatori M: Advantages of multidetector-row CT with multiplanar reformation in guiding percutaneous lung biopsies. Radiol Med; 2008 Oct;113(7):945-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Advantages of multidetector-row CT with multiplanar reformation in guiding percutaneous lung biopsies.
  • PURPOSE: This study aimed to assess the usefulness of multiplanar reformations (MPR) during multidetector-row computed tomography (MDCT)-guided percutaneous needle biopsy of lung lesions difficult to access with the guidance of the native axial images alone owing to overlying bony structures, large vessels or pleural fissures.
  • MATERIALS AND METHODS: MDCT-guided transthoracic needle biopsy (TNB) was performed on 84 patients (55 men and 29 women; mean age 65 years) with suspected lung neoplasm by using a spiral MDCT scanner with the simultaneous acquisition of six slices per rotation.
  • We took care to ensure the shortest needle path without overlying large vessels, main bronchi, pleural fissures or bony structures; access to the lung parenchyma as perpendicular as possible to the pleural plane; and sampling of highly attenuating areas of noncalcified tissue within the lesion.
  • [MeSH-major] Biopsy, Needle / methods. Image Processing, Computer-Assisted. Lung / pathology. Lung Neoplasms / diagnostic imaging. Lung Neoplasms / pathology. Tomography, Spiral Computed / methods
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / diagnostic imaging. Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / diagnostic imaging. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Aged. Carcinoid Tumor / diagnosis. Carcinoid Tumor / diagnostic imaging. Carcinoid Tumor / pathology. Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Non-Small-Cell Lung / diagnostic imaging. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / diagnostic imaging. Carcinoma, Small Cell / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / diagnostic imaging. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Humans. Lymphoma / diagnosis. Lymphoma / diagnostic imaging. Lymphoma / pathology. Lymphomatoid Granulomatosis / diagnosis. Lymphomatoid Granulomatosis / diagnostic imaging. Lymphomatoid Granulomatosis / pathology. Male. Mesothelioma / diagnosis. Mesothelioma / diagnostic imaging. Mesothelioma / pathology. Middle Aged. Needles

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  • (PMID = 18818985.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Italy
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65. Blons H, Côté JF, Le Corre D, Riquet M, Fabre-Guilevin E, Laurent-Puig P, Danel C: Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation. Am J Surg Pathol; 2006 Oct;30(10):1309-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation.
  • In lung cancer, an association was made between drastic clinical response to epidermal growth factor receptor (EGFR) inhibitors and the presence of somatic mutations within the tyrosine kinase domain of the EGFR.
  • To go further in the characterization of the EGF pathway, we screened EGFR, ERBB2, ERBB3, KRAS, BRAF, and PIK3CA for mutations in 2 groups of White patients with nonsmall cell lung cancer (45 cancers from women and 46 cancers from men).
  • We demonstrated that EGFR mutations were linked to female sex, absence of smoking, late age at diagnosis, and adenocarcinoma (ADC) with bronchioloalveolar (BAC) features.
  • Moreover, in invasive ADC with BAC component, microdissection assays showed that mutations were retrieved in both tumor subtypes suggesting that EGFR mutations appear early in lung carcinogenesis.
  • On the contrary, KRAS mutations correlated with smoking, younger age at diagnosis, and ADC subtype regardless of BAC differentiation.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / genetics. Carcinoma, Non-Small-Cell Lung / genetics. Lung Neoplasms / genetics. Mutation. Receptor, Epidermal Growth Factor / genetics


66. Damhuis RA, Schütte PR, Varin OC, van den Berg PM, Heinhuis R, Plaisier PW: Poor results after surgery for bronchioloalveolar carcinoma. Eur J Surg Oncol; 2006 Jun;32(5):573-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Bronchioloalveolar carcinoma (BAC) is suggested to be less aggressive than other types of lung cancer.
  • To assess the option of treatment modification, actual outcome data were studied and compared with results for other types of lung cancer.
  • METHOD: Retrospective analysis of all consecutive patients who underwent resection for stage I lung cancer in our hospital.
  • For 18 BAC cases, histological specimens were re-evaluated and in three cases diagnosis was revised.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / surgery. Adult. Age Factors. Aged. Carcinoma, Large Cell / surgery. Carcinoma, Squamous Cell / surgery. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Pneumonectomy / classification. Postoperative Complications. Retrospective Studies. Sex Factors. Survival Rate. Treatment Outcome

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  • (PMID = 16580808.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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67. Wu M, Orta L, Gil J, Li G, Hu A, Burstein DE: Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma. Mod Pathol; 2008 May;21(5):553-8
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  • [Title] Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma.
  • The critical distinction of bronchioloalveolar carcinoma (BAC), well-differentiated adenocarcinoma (WDAC) of lung, adenomatous hyperplasia (AH) and atypical adenomatous hyperplasia (AAH), is based on morphological criteria alone, and is therefore potentially subjective.
  • Neither XIAP nor p63 were detected in normal lung alveolar cells.
  • In contrast, diffuse p63 staining may facilitate the identification of rare cases that may have been misclassified as alveolar in origin based on morphology but may be of BRC origin.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Membrane Proteins / biosynthesis. Precancerous Conditions / diagnosis. X-Linked Inhibitor of Apoptosis Protein / biosynthesis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Hyperplasia / pathology. Immunohistochemistry. Lung / pathology

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  • (PMID = 18432259.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / X-Linked Inhibitor of Apoptosis Protein; 0 / XIAP protein, human
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68. Asher Prince HM, Hatter JE: Case of the month. Concurrent diagnosis of lung cancer and tuberculosis. JAAPA; 2005 Feb;18(2):68
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  • [Title] Case of the month. Concurrent diagnosis of lung cancer and tuberculosis.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / complications. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / complications. Lung Neoplasms / diagnosis. Tuberculosis, Pulmonary / complications. Tuberculosis, Pulmonary / diagnosis

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  • (PMID = 15742785.001).
  • [ISSN] 1547-1896
  • [Journal-full-title] JAAPA : official journal of the American Academy of Physician Assistants
  • [ISO-abbreviation] JAAPA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Awab A, Hamadani M, Peyton M, Brown B: False-negative PET scan with bronchioloalveolar carcinoma: an important diagnostic caveat. Am J Med Sci; 2007 Oct;334(4):311-3
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  • Positron emission tomography (PET) is becoming widely accepted as a powerful diagnostic tool for the diagnosis of lung cancer, but it has very poor sensitivity for the detection of bronchioloalveolar carcinoma (BAC) and adenocarcinoma with BAC pattern, the less common form of pulmonary neoplasia.
  • PET has a reported sensitivity of over 98% in most series but misses almost two-thirds of BAC lesions, which might delay invasive testing and early diagnosis of this potentially lethal cancer.
  • Although this diagnostic limitation has been well reported in the radiology literature, the high reported sensitivity and sensitivity can give clinicians a false sense of security with negative PET scans of lung nodules.
  • The usual risk factors for bronchogenic carcinoma are less reliable for these subtypes of non-small-cell lung cancer; thus, clinicians need to have a high index of suspicion for BAC and exercise caution when making decisions on the basis of PET.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radionuclide imaging. Lung Neoplasms / radionuclide imaging

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  • (PMID = 18030191.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Hsu WH, Huang CS, Hsu HS, Huang WJ, Lee HC, Huang BS, Huang MH: Preoperative serum carcinoembryonic antigen level is a prognostic factor in women with early non-small-cell lung cancer. Ann Thorac Surg; 2007 Feb;83(2):419-24
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  • [Title] Preoperative serum carcinoembryonic antigen level is a prognostic factor in women with early non-small-cell lung cancer.
  • BACKGROUND: Carcinoembryonic antigen (CEA) is one of the markers evaluated in patients with non-small cell lung cancer (NSCLC).
  • Diagnosis of adenocarcinoma and bronchoalveolar carcinoma accounted for 83.4% of these 163 female patients.
  • [MeSH-major] Carcinoembryonic Antigen / blood. Carcinoma, Non-Small-Cell Lung / blood. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / blood. Lung Neoplasms / surgery. Preoperative Care. Pulmonary Surgical Procedures
  • [MeSH-minor] Adenocarcinoma / blood. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / blood. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Adult. Age Factors. Aged. Aged, 80 and over. Female. Humans. Middle Aged. Multivariate Analysis. Neoplasm Invasiveness. Neoplasm Staging. Pleura / pathology. Prognosis. Retrospective Studies

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  • [CommentIn] Ann Thorac Surg. 2007 Feb;83(2):424 [17257964.001]
  • (PMID = 17257963.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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71. Zell JA, Ou SH, Ziogas A, Anton-Culver H: Long-term survival differences for bronchiolo-alveolar carcinoma patients with ipsilateral intrapulmonary metastasis at diagnosis. Ann Oncol; 2006 Aug;17(8):1255-62
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  • [Title] Long-term survival differences for bronchiolo-alveolar carcinoma patients with ipsilateral intrapulmonary metastasis at diagnosis.
  • BACKGROUND: It has been suggested that the current staging system does not accurately reflect survival outcomes for advanced bronchiolo-alveolar carcinoma (BAC) patients.
  • Overall survival (OS) and lung cancer-specific survival (LCSS) univariate analyses were conducted using the Kaplan-Meier method.

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  • (PMID = 16766595.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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72. Goo JM, Kim HY, Lee JW, Lee HJ, Lee CH, Lee KW, Kim TJ, Lim KY, Park SH, Bae KT: Is the computer-aided detection scheme for lung nodule also useful in detecting lung cancer? J Comput Assist Tomogr; 2008 Jul-Aug;32(4):570-5
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  • [Title] Is the computer-aided detection scheme for lung nodule also useful in detecting lung cancer?
  • OBJECTIVE: To evaluate the impact of a computer-aided diagnosis (CAD) system on the performance of observers for the detection of both lung nodules and lung cancers.
  • Database included 23 lung cancers (long diameter <20 mm), nodules stable for at least 2 years, and normal cases.
  • RESULTS: The performance of detecting lung nodules was increased significantly with CAD for all radiologists and subgroups (P < 0.01).
  • Although the overall performance of detecting lung cancers was not affected significantly with the use of CAD (P > 0.05), 4 lung cancers missed by 3 residents on their initial observation were additionally detected with CAD.
  • Eighteen of 23 lung cancers were detected by CAD itself.
  • CONCLUSIONS: The overall radiologists' performance of detecting lung nodules was improved significantly with the use of CAD, whereas no statistical significance was observed for the detection of lung cancers.
  • The use of CAD, however, contributed to the detection of additional lung cancers for less experienced readers.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Carcinoma, Non-Small-Cell Lung / diagnosis. Diagnosis, Computer-Assisted / methods. Lung Neoplasms / diagnosis. Radiographic Image Interpretation, Computer-Assisted / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Imaging, Three-Dimensional / methods. Lung / radiography. Male. Middle Aged. Observer Variation. Reference Standards. Reproducibility of Results. Retrospective Studies


73. Cheung WY, Hwang DM, Chung TB, Johnston MR, Leighl NB: Initial treatment strategies and outcomes for multifocal bronchioloalveolar carcinoma. Clin Lung Cancer; 2009 May;10(3):187-92
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  • Median age at diagnosis was 65 years; the majority of the patients were female (64%), were non-Asian (82%), and had a smoking history (66%).
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / therapy. Lung Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / therapy. Female. Humans. Male. Middle Aged. Multivariate Analysis

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  • (PMID = 19443339.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. West H: Emerging approaches to advanced bronchioloalveolar carcinoma. Curr Treat Options Oncol; 2006 Jan;7(1):69-76
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  • Bronchioloalveolar carcinoma (BAC) is a subtype of non-small cell lung adenocarcinoma that has distinct epidemiologic, histologic, radiographic, and clinical features.
  • The strict pathologic definition requires an absence of any invasion through the basement membrane into pulmonary parenchyma, but there is a growing consensus based on recent clinical studies that this diagnosis should be considered to be based on the clinical features of diffuse ground-glass opacities with minimal or no extra-thoracic spread and histology demonstrating adenocarcinoma with a lepidic growth pattern characteristic of BAC, even if there is a component of invasive adenocarcinoma.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Antineoplastic Agents / therapeutic use. Lung Neoplasms / drug therapy. Lung Neoplasms / pathology

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  • (PMID = 16343370.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 58
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75. Ramos SG, Barbosa GH, Tavora FR, Jeudy J, Torres LA, Tone LG, Trad CS: Bronchioloalveolar carcinoma arising in a congenital pulmonary airway malformation in a child: case report with an update of this association. J Pediatr Surg; 2007 May;42(5):E1-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Cystic Adenomatoid Malformation of Lung, Congenital / pathology. Lung Neoplasms / pathology
  • [MeSH-minor] Child. Diagnosis, Differential. Fatal Outcome. Female. Humans. Tomography, X-Ray Computed

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  • (PMID = 17502169.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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76. Felner KJ, Wieczorek R, Kline M, Smith RL, Sidhu GS: Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules. Int J Surg Pathol; 2006 Jul;14(3):229-33
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  • [Title] Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules.
  • Thoracoscopic biopsy revealed multiple discrete nodules in the pleura and lung.
  • The latter consisted of tall columnar malignant cells arranged on alveolar surfaces in a lepidic growth pattern.
  • Mucin filled the alveolar lumina, both in the nodules and surrounding lung.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Mesothelioma / diagnosis. Pleural Neoplasms / diagnosis. Solitary Pulmonary Nodule / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Humans. Hyaluronic Acid / metabolism. Male. Microscopy, Electron, Transmission. Microvilli / ultrastructure. Mucins / metabolism. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 16959710.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 9004-61-9 / Hyaluronic Acid
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77. Patsios D, Roberts HC, Paul NS, Chung T, Herman SJ, Pereira A, Weisbrod G: Pictorial review of the many faces of bronchioloalveolar cell carcinoma. Br J Radiol; 2007 Dec;80(960):1015-23
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  • Bronchioloalveolar cell carcinoma (BAC) has a varied appearance on CT that often leads to an incorrect or delayed diagnosis.
  • These features should alert the radiologist to the diagnosis of BAC.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography

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  • (PMID = 17940131.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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78. Tasci S, Lentini S, Manka R, Friedrichs N, Lüderitz B: [Progressive upper lobe consolidation in a 73-year old healthy woman]. Internist (Berl); 2005 Feb;46(2):195-201
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  • CT-scan and bronchoscopy with bronchoalveolar lavage could not yield a specific diagnosis.
  • Due to progression of the consolidation in a CT scan after 10 weeks another bronchoscopy with transbronchial biopsy was performed and yielded bronchiolo-alveolar carcinoma.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnostic imaging. Incidental Findings. Lung Neoplasms / diagnostic imaging. Pacemaker, Artificial. Sick Sinus Syndrome / therapy. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Biopsy. Bronchoalveolar Lavage Fluid. Bronchoscopy. Diagnosis, Differential. Disease Progression. Female. Follow-Up Studies. Humans. Lung / pathology. Lymph Node Excision. Neoplasm Staging. Pneumonectomy


79. Erickson TM, Koeppe JR, Miller YE, Stuart RW, Camidge DR: Bronchioloalveolar carcinoma presenting as chronic progressive pulmonary infiltrates in a woman with HIV: a diagnosis worth making. J Thorac Oncol; 2008 Nov;3(11):1353-5
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  • [Title] Bronchioloalveolar carcinoma presenting as chronic progressive pulmonary infiltrates in a woman with HIV: a diagnosis worth making.
  • After 14 months a solitary lung nodule developed which was excised.
  • This demonstrated an invasive adenocarcinoma with an activating epidermal growth factor receptor mutation (exon 19 deletion).
  • We discuss the diagnosis and treatment of lung cancer in HIV-positive populations and review the general and specific characteristics of bronchioloalveolar carcinoma, including response to epidermal growth factor receptor inhibitors, and known mechanisms of acquired resistance.
  • The predilection for lung cancer in HIV-positive patients, the diffuse nature of bronchioloalveolar carcinoma that can mimic infectious etiologies and the potential for dramatic responses to therapy make this an important diagnosis to consider in this setting.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. HIV / pathogenicity. HIV Infections / complications. Lung Diseases, Interstitial / diagnosis
  • [MeSH-minor] Chronic Disease. Diagnosis, Differential. Erlotinib Hydrochloride. Female. Humans. Middle Aged. Mutation / genetics. Prognosis. Protein Kinase Inhibitors / therapeutic use. Quinazolines / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors


80. Travis WD, Garg K, Franklin WA, Wistuba II, Sabloff B, Noguchi M, Kakinuma R, Zakowski M, Ginsberg M, Padera R, Jacobson F, Johnson BE, Hirsch F, Brambilla E, Flieder DB, Geisinger KR, Thunnisen F, Kerr K, Yankelevitz D, Franks TJ, Galvin JR, Henderson DW, Nicholson AG, Hasleton PS, Roggli V, Tsao MS, Cappuzzo F, Vazquez M: Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol; 2005 May 10;23(14):3279-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.
  • PURPOSE: To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC).
  • METHODS: A pathology/CT review panel of pathologists and radiologists met during a November 2004 International Association for the Study of Lung Cancer/American Society of Clinical Oncology consensus workshop in New York.
  • The purpose was to determine if existing data was sufficient to propose modification of criteria for adenocarcinoma and BAC as newly published in the 2004 WHO Classification of Lung Tumors, and to address the pathologic/radiologic concept of diffuse/multicentric BAC.
  • Most lung adenocarcinomas with a BAC pattern are not pure BAC, but rather adenocarcinoma, mixed subtype with invasive patterns.
  • The percent of BAC versus invasive components in lung adenocarcinomas appears to be prognostically important.
  • While recognition of a BAC component is possible, the diagnosis of BAC with exclusion of invasive adenocarcinoma cannot be made by small biopsy or cytology specimens.
  • CONCLUSION: There is a need to work toward a mutual understanding and consensus between pathologists, clinicians, and researchers with the use of the term BAC versus adenocarcinoma.
  • Hopefully, this work will allow definition of a category of adenocarcinoma, mixed subtype with predominant BAC/minimal invasion and a favorable prognosis.
  • [MeSH-major] Adenocarcinoma / radiography. Lung Neoplasms / radiography
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Humans. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 15886315.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 67
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81. Lyons G, Quadrelli S, Chimondegy D, Iotti A, Silva C: [Bronchioalveolar carcinoma: five year survival]. Medicina (B Aires); 2006;66(4):313-8
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  • The epidemiology and prognosis of bronchioalveolar carcinoma (BAC) is different from adenocarcinoma.
  • We studied 28 patients who underwent surgical resection and in whom a final histologic diagnosis of bronchioalveolar carcinoma was made.
  • Sixty one percent of patients were asymptomatic at the time of diagnosis.
  • Bronchoscopy provided the diagnosis only in 4/26 patients.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / mortality. Lung Neoplasms / mortality
  • [MeSH-minor] Adenocarcinoma, Mucinous / mortality. Adenocarcinoma, Mucinous / pathology. Bronchoscopy. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 16977966.001).
  • [ISSN] 0025-7680
  • [Journal-full-title] Medicina
  • [ISO-abbreviation] Medicina (B Aires)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Argentina
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82. Cobo Dols M, Gil Calle S, Alés Díaz I, Villar Chamorro E, Alcaide García J, Gutiérrez Calderón V, Benavides Orgaz M: Bronchiolitis obliterans organizing pneumonia simulating progression in bronchioloalveolar carcinoma. Clin Transl Oncol; 2006 Feb;8(2):133-5
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  • The diagnosis of BOOP requires the presence of a combination of pathological, clinical, and radiological features.
  • We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Cryptogenic Organizing Pneumonia / diagnosis. Lung Neoplasms / diagnosis
  • [MeSH-minor] Anti-Inflammatory Agents / therapeutic use. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Diagnosis, Differential. Disease Progression. Humans. Male. Methylprednisolone / therapeutic use. Middle Aged. Respiratory Insufficiency / etiology. Taxoids / administration & dosage. Tomography, X-Ray Computed

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  • [Cites] J Clin Oncol. 2005 May 10;23 (14 ):3279-87 [15886315.001]
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  • (PMID = 16632429.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Taxoids; 0W860991D6 / Deoxycytidine; 15H5577CQD / docetaxel; B76N6SBZ8R / gemcitabine; X4W7ZR7023 / Methylprednisolone
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83. Misao T, Minamoto K, Nakano H, Yamane M, Yamamoto Y, Satoh K: Effect of gravitation for detection of bronchioloalveolar carcinoma on computed tomography. Jpn J Thorac Cardiovasc Surg; 2005 Jun;53(6):309-12
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  • Middle lobectomy with video-assisted thoracoscopic surgery (VATS) was undertaken, and pathological diagnosis was a bronchioloalveolar carcinoma (BAC) in stage IA.
  • A follow-up CT a year following the surgery revealed localized GGO in area S6 of the left lung.
  • Left extended S6 segmentectomy with VATS was performed, and pathological diagnosis was a BAC in stage IA.
  • As GGO existing in a gravitation-dependent area may be masked by the gravitation-dependent density, a change of the scanning position may lead to a proper detection of the tumor for the diagnosis of BAC.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Gravitation. Lung Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 15997753.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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84. Okada M: Invited commentary. Ann Thorac Surg; 2009 Oct;88(4):1111
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  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / surgery. Lung Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Diagnosis, Differential. Disease-Free Survival. Humans. Intraoperative Period. Japan / epidemiology. Survival Rate / trends. Treatment Outcome

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  • [CommentOn] Ann Thorac Surg. 2009 Oct;88(4):1106-11 [19766789.001]
  • (PMID = 19766790.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Netherlands
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85. Vasile E, Tibaldi C, Chella A, Falcone A: Erlotinib after failure of gefitinib in patients with advanced non-small cell lung cancer previously responding to gefitinib. J Thorac Oncol; 2008 Aug;3(8):912-4
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  • [Title] Erlotinib after failure of gefitinib in patients with advanced non-small cell lung cancer previously responding to gefitinib.
  • BACKGROUND: Gefitinib and erlotinib are two orally active epidermal growth factor receptor tyrosine kinase inhibitors used in the treatment of advanced non-small cell lung cancer (NSCLC).
  • RESULTS: Four patients were women; histologic diagnosis was adenocarcinoma in four cases and bronchoalveolar carcinoma or unspecified NSCLC in two cases each.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy. Protein Kinase Inhibitors / therapeutic use. Quinazolines / therapeutic use
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Aged. Aged, 80 and over. Erlotinib Hydrochloride. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Survival Rate. Treatment Outcome

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  • (PMID = 18670311.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; S65743JHBS / gefitinib
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86. Bryant AS, Cerfolio RJ: The maximum standardized uptake values on integrated FDG-PET/CT is useful in differentiating benign from malignant pulmonary nodules. Ann Thorac Surg; 2006 Sep;82(3):1016-20
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  • [MeSH-major] Fluorodeoxyglucose F18 / pharmacokinetics. Lung Diseases / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals / pharmacokinetics. Solitary Pulmonary Nodule / radionuclide imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Bronchiolo-Alveolar / radionuclide imaging. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Aged. Carcinoid Tumor / pathology. Carcinoid Tumor / radiography. Carcinoid Tumor / radionuclide imaging. Carcinoid Tumor / surgery. Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / radiography. Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Carcinoma, Non-Small-Cell Lung / surgery. Carcinoma, Renal Cell / radiography. Carcinoma, Renal Cell / radionuclide imaging. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Diagnosis, Differential. False Negative Reactions. False Positive Reactions. Female. Frozen Sections. Humans. Lung Diseases, Fungal / radiography. Lung Diseases, Fungal / radionuclide imaging. Lymphatic Metastasis. Male. Middle Aged. Thoracic Surgery, Video-Assisted

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  • (PMID = 16928527.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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87. Griffiths DJ, Martineau HM, Cousens C: Pathology and pathogenesis of ovine pulmonary adenocarcinoma. J Comp Pathol; 2010 May;142(4):260-83
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  • [Title] Pathology and pathogenesis of ovine pulmonary adenocarcinoma.
  • Ovine pulmonary adenocarcinoma (OPA), also known as jaagsiekte, is a transmissible lung tumour of sheep caused by jaagsiekte sheep retrovirus (JSRV).
  • JSRV induces neoplastic transformation of alveolar and bronchiolar secretory epithelial cells and the resulting tumours can grow to occupy a significant portion of the lung.
  • Tumour growth is frequently accompanied by the overproduction of fluid in the lung, which further compromises normal respiration.
  • In addition to its veterinary importance, OPA is regarded as a potential large animal model for human lung adenocarcinoma and this has stimulated research into the pathogenesis of the ovine disease.
  • The recent advances in understanding JSRV and the pathogenesis of OPA should lead to novel strategies for diagnosis and control of this disease and for its exploitation as a comparative model for human lung cancer.
  • [MeSH-major] Adenocarcinoma / virology. Jaagsiekte sheep retrovirus / physiology. Pulmonary Adenomatosis, Ovine. Sheep Diseases / virology
  • [MeSH-minor] Animals. Body Fluids / virology. Epithelial Cells / pathology. Epithelial Cells / virology. Humans. Lung / pathology. Lung / virology. Lung Neoplasms / genetics. Lung Neoplasms / pathology. Lung Neoplasms / virology. Models, Animal. Sheep / genetics. Sheep / virology. Sheep, Domestic / genetics. Sheep, Domestic / virology

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20163805.001).
  • [ISSN] 1532-3129
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 171
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88. Ulmeanu R, Mihăltan F, Crişan E, Alexe M, Grigore P, Andreescu I, Galbenu P, Leonte D: [Practical issues of transbronchial lung biopsy (TLB) in pneumology]. Pneumologia; 2007 Apr-Jun;56(2):59-67
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  • [Title] [Practical issues of transbronchial lung biopsy (TLB) in pneumology].
  • METHOD: We present a survey of 78 TLB which have been performed in Bronchology Service (during 2003-2005) for diffuse interstitial lung diseases--70 cases or located diseases--8 cases; TLB was not performed for solitary peripherally opacities because we have no radiological device with mobile arm (for good position of forceps).
  • RESULTS: In 78% of cases we obtained illustrative lung tissue and in 22% of cases we prelevated just bronchial wall.
  • Histological confirmation was obtained for 53% of cases; 47% of cases have as result lung tissue without significant modifications.
  • Histological diagnosis was obtain in 41% of cases.
  • The diagnosis of lung pathology was: diffuse lung fibrosis, tuberculosis, sarcoidosis stage II-III, malignant lymphoma, carcinomatosis, undifferentiated carcinoma, bronchioloalveolar carcinoma, squamous carcinoma, adenocarcinoma.
  • The international guidelines request that the TLB has to be made before the thoracoscopy or the thoracotomy; because of the small size of prelevated fragments the diagnosis sensibility is variable.
  • Our results for the 78 cases are comparable with the international data from literature both from the point of view of the diagnosis and the complications.
  • [MeSH-major] Biopsy, Needle / methods. Bronchoscopy. Lung Diseases / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma, Bronchiolo-Alveolar / pathology. Aged. Carcinoma, Squamous Cell / pathology. Diagnosis, Differential. Female. Granulomatosis with Polyangiitis / pathology. Health Surveys. Humans. Lung Neoplasms / pathology. Lymphoma, Non-Hodgkin / pathology. Male. Middle Aged. Practice Guidelines as Topic. Pulmonary Fibrosis / pathology. Sarcoidosis, Pulmonary / pathology. Sensitivity and Specificity. Tuberculosis, Pulmonary / pathology

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  • (PMID = 18019749.001).
  • [ISSN] 2067-2993
  • [Journal-full-title] Pneumologia (Bucharest, Romania)
  • [ISO-abbreviation] Pneumologia
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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89. Isobe K, Hata Y, Sugino K, Takai Y, Shibuya K, Homma S: [Usefulness of FDG-PET for diagnosis of lung cancer associated with interstitial pneumonia]. Nihon Kokyuki Gakkai Zasshi; 2009 Apr;47(4):278-85
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  • [Title] [Usefulness of FDG-PET for diagnosis of lung cancer associated with interstitial pneumonia].
  • AIM: The aim of this study was to demonstrate the usefulness of FDG-PET for diagnosis of lung cancer associated with interstitial pneumonia (IP), clinicopathologically.
  • SUBJECTS AND METHODS: 32 patients with IP-associated lung cancer (IP-LC group) and 26 patients with IP not associated with lung cancer (IP group) underwent 18-fluorodeoxyglucose positron emission tomography (FDG-PET) for diagnostic procedure from April 2004 through October 2007.
  • Standard uptake values (SUV) were compared between IP and lung cancer fields in two groups.
  • In addition, expression of Glut-1, MIB-1, and p53 in the resected lung tissues (n=10) were analyzed.
  • RESULTS: There was a significant difference in SUVs between lung cancer fields and IP fields.
  • However, it was difficult to distinguish the fields of well-differentiated adenocarcinoma from IP by SUV.
  • Red blood cells in the vessels along the alveolar walls, hyperplastic alveolar type II cells, and squamous metaplastic cells in the fibrotic lung tissues revealed expression of Glut-1.
  • In addition, hyperplastic alveolar type II cells and metaplastic cells also revealed expression of MIB-1 and p53.
  • CONCLUSION: The elevation of SUV in IP fields can be caused by neovascularization and/or hyperplasia of alveolar type II cells and metaplastic cells in the fibrotic lesions.
  • [MeSH-major] Fluorodeoxyglucose F18. Lung Diseases, Interstitial / radionuclide imaging. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography

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  • (PMID = 19455956.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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90. Noguchi M, Minami Y, Iijima T, Matsuno Y: Reproducibility of the diagnosis of small adenocarcinoma of the lung and usefulness of an educational program for the diagnostic criteria. Pathol Int; 2005 Jan;55(1):8-13
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  • [Title] Reproducibility of the diagnosis of small adenocarcinoma of the lung and usefulness of an educational program for the diagnostic criteria.
  • Using 32 small adenocarcinomas of the lung including bronchioloalveolar carcinoma (BAC), the reproducibility of diagnosis by the modified diagnostic criteria for small adenocarcinoma (Cancer 75; 2844, 1995) and the effectiveness of an educational program for 27 volunteer general pathologists were examined.
  • The average coincidence rate of the diagnosis before and after the program was 42.4% and 56.6%, respectively.
  • In contrast, the average coincidence rate of six lung cancer specialists was 71.4%, and this was significantly higher than that for general pathologists after the program (P < 0.05).
  • When the cases were divided into two groups (in situ adenocarcinoma (BAC and BAC with alveolar collapse) and early invasive adenocarcinoma), the average coincidence rate for the general pathologists after the program increased to 85.3%, which was significantly higher than that before the program (80.3%; P < 0.05).
  • This trial was thought to provide a theoretical background for the histological diagnosis of peripheral type adenocarcinoma of the lung and to justify the existing diagnostic criteria.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma in Situ / diagnosis. Lung Neoplasms / diagnosis. Pathology, Surgical / education
  • [MeSH-minor] Diagnosis, Differential. Humans. Reproducibility of Results

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  • (PMID = 15660697.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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91. Aida S, Ohara I, Shimazaki H, Dai Y, Ogata S, Ozeki Y, Tamai S: Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases. Am J Surg Pathol; 2008 Oct;32(10):1489-94
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  • [Title] Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases.
  • We report 3 cases of solitary papillomas located in peripheral regions of the lung that are extremely rare in the literature.
  • The neoplastic epithelium extended to the alveolar region and showed a similar appearance to bronchioloalveolar or papillary type adenocarcinomas.
  • For differential diagnosis, it is noteworthy that endobronchiolar papillomatous fronds constantly exist and spreading along alveolar walls is limited in adjacent alveoli in peripheral papillomas.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Bronchial Neoplasms / pathology. Lung Neoplasms / pathology. Neoplasms, Glandular and Epithelial / pathology. Papilloma / pathology. Solitary Pulmonary Nodule / pathology
  • [MeSH-minor] Aged. Bronchi / pathology. Cilia / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Middle Aged. Pulmonary Alveoli / pathology. Respiratory Mucosa / pathology

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  • (PMID = 18708941.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Edey AJ, Hansell DM: Incidentally detected small pulmonary nodules on CT. Clin Radiol; 2009 Sep;64(9):872-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Lung Neoplasms / radiography. Multiple Pulmonary Nodules / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Calcinosis / radiography. Diagnosis, Differential. Hamartoma / radiography. Humans. Incidental Findings. Lung. Lymph Nodes / pathology. Lymph Nodes / radiography. Middle Aged. Practice Guidelines as Topic. Radiation Dosage. Reproducibility of Results. Risk Factors. Time Factors

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  • (PMID = 19664477.001).
  • [ISSN] 1365-229X
  • [Journal-full-title] Clinical radiology
  • [ISO-abbreviation] Clin Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 78
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93. Dillman RO, Zusman DR, McClure SE: Surgical resection and long-term survival for octogenarians who undergo surgery for non-small-cell lung cancer. Clin Lung Cancer; 2009 Mar;10(2):130-4
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  • [Title] Surgical resection and long-term survival for octogenarians who undergo surgery for non-small-cell lung cancer.
  • PURPOSE: An increasing proportion of newly diagnosed non-small-cell lung cancer (NSCLC) patients are octogenarians.
  • It has been questioned whether older patients benefit from surgical resection of lung cancer to the same extent as younger patients.
  • PATIENTS AND METHODS: We conducted a single-institution, retrospective analysis of patients newly diagnosed with NSCLC from 2000-2006, who underwent surgical resection of their lung cancer in Hoag Hospital.
  • RESULTS: The proportion of patients who had local disease at diagnosis was higher for octogenarians compared with younger patients (33.6% vs. 26.6%; P = .021), but the resection rate for octogenarians was lower (64% vs. 83%; P = .0003).
  • CONCLUSION: Non-small-cell lung cancer patients < 80 years of age were less likely to undergo potentially curative surgery, but survival for octogenarians who did undergo surgical resection was comparable to younger age groups.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / mortality. Lung Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adenocarcinoma, Bronchiolo-Alveolar / mortality. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Age Factors. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 19362957.001).
  • [ISSN] 1525-7304
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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94. Shvartsbeyn M, Edelman MJ: Pemetrexed-induced typhlitis in non-small cell lung cancer. J Thorac Oncol; 2008 Oct;3(10):1188-90
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  • [Title] Pemetrexed-induced typhlitis in non-small cell lung cancer.
  • Food and Drug Administration-approved as a second line, single-agent treatment of recurrent metastatic non-small cell lung cancer.
  • The diagnosis is supported by the findings of bowel wall thickening on computed tomographic imaging.
  • [MeSH-major] Antineoplastic Agents / adverse effects. Carcinoma, Non-Small-Cell Lung / drug therapy. Glutamates / adverse effects. Guanine / analogs & derivatives. Lung Neoplasms / drug therapy. Typhlitis / chemically induced
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / complications. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adult. Female. Humans. Pemetrexed. Thymidylate Synthase / antagonists & inhibitors. Tomography, X-Ray Computed

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  • (PMID = 18827618.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; EC 2.1.1.45 / Thymidylate Synthase
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95. Raz DJ, Jablons DM: Bronchioloalveolar carcinoma is not associated with younger age at diagnosis: an analysis of the SEER database. J Thorac Oncol; 2006 May;1(4):339-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bronchioloalveolar carcinoma is not associated with younger age at diagnosis: an analysis of the SEER database.
  • INTRODUCTION: Bronchioloalveolar carcinoma (BAC) is a unique subtype of non-small cell lung cancer (NSCLC) that is associated with female gender, Asian ethnicity, and never-smoking status.
  • Although BAC is commonly reported to occur more frequently in young people with lung cancer, there is a lack of evidence to support this association.
  • METHODS: We analyzed the association between age at diagnosis and NSCLC histology among 293,417 incident cases of NSCLC in the Surveillance Epidemiology, and End Results (SEER) database during the years 1973 to 2002.
  • Although a greater percentage of women and Asian patients with lung cancer were younger than 50 years old, the proportion of patients with BAC was similar to the proportion of men and non-Asians with BAC.
  • Finally, the prevalence of BAC histology among patients younger than 50 years did not change significantly after revision of the 1999 World Health Organization pathologic criteria for the diagnosis of BAC (risk ratio 0.93 versus 0.87, p = 0.31).
  • CONCLUSION: BAC is not associated with a younger mean age at diagnosis, nor is it associated with an age of less than 50 years at diagnosis.

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  • (PMID = 17409881.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA093708-02; United States / NCI NIH HHS / CA / R01 CA093708; United States / NCI NIH HHS / CA / R01 CA093708-02
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Sabloff BS, Wistuba II, Erasmus JJ: Cystic bronchioloalveolar cell carcinoma. J Thorac Imaging; 2005 May;20(2):110-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Bronchioloalveolar cell carcinomas (BACs), a subset of primary lung adenocarcinomas, are uncommon.
  • Similar to other non-small cell lung cancers, patients with BAC are usually 40-70 years of age.
  • Distinguishing features relative to other non-small cell lung cancers include occurrence in young patients, a higher relative predominance in women, and weaker association with smoking.
  • Knowledge of the spectrum of radiologic manifestations of BAC and correlation with clinical history are important in suggesting the diagnosis and preventing misinterpretation.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / diagnosis. Lung Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy, Needle / methods. Cough / etiology. Diagnosis, Differential. Female. Humans. Lung / pathology. Lung / radiography. Male. Middle Aged

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  • (PMID = 15818211.001).
  • [ISSN] 0883-5993
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Shaw ND, Hoover EL: Postoperative pleural effusion in bronchioloalveolar cancer. Ann Thorac Surg; 2005 Sep;80(3):1124-6
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  • Bronchioloalveolar carcinoma occasionally presents with bronchorrhea and can appear on roentgenogram as cavitary lesions similar to a lung abscess.
  • We present a case of multifocal, cavitary bronchioloalveolar cancer, which was originally treated unsuccessfully as lung abscesses.
  • This report chronicles our difficulty with diagnosis and management and suggests recommendations for future providers.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / complications. Adenocarcinoma, Bronchiolo-Alveolar / surgery. Pleural Effusion / etiology

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  • (PMID = 16122510.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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98. Lebensburger J, Katzenstein H, Jenkins JJ, Rodriguez-Galindo C: Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors. Pediatr Blood Cancer; 2009 Sep;53(3):499-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / etiology. Bone Neoplasms / therapy. Lung Neoplasms / etiology. Neoplasms, Second Primary / etiology. Osteosarcoma / therapy. Survivors

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19418544.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 21765; United States / NCI NIH HHS / CA / P30 CA23099
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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99. Priest JR, Williams GM, Hill DA, Dehner LP, Jaffé A: Pulmonary cysts in early childhood and the risk of malignancy. Pediatr Pulmonol; 2009 Jan;44(1):14-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Surgery for congenital and early childhood lung cysts is often dictated by symptoms such as respiratory distress, infection or pneumothorax.
  • Pleuropulmonary blastoma (PPB) is the most frequent malignancy associated with childhood lung cysts.
  • The earliest manifestation of PPB is a malignant lung cyst in young children, clinically and radiographically indistinguishable from benign congenital lung cysts.
  • Numerous reports of "malignancy in a congenital lung cyst" are now understood as the characteristic progression of cystic PPB.
  • Detailed family history may reveal the hallmarks of PPB in the patient or young relatives: a unique constellation of diseases including lung cysts, cystic nephroma, childhood cancers, stromal sex-chord ovarian tumors, seminomas or dysgerminomas, intestinal polyps, thyroid hyperplasias, and hamartomas.
  • Pneumothorax and multifocal/bilateral lung cysts also characterize PPB.
  • These diagnoses predict that a lung cyst is more likely PPB than a benign congenital cyst.
  • Patients fitting this pattern deserve histologic diagnosis.
  • [MeSH-major] Cysts / pathology. Lung Diseases / pathology. Lung Neoplasms / pathology. Pleural Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Child. Diagnosis, Differential. Genetic Predisposition to Disease. Humans. Pulmonary Blastoma / pathology. Risk Factors

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  • [Copyright] Copyright 2008 Wiley-Liss, Inc.
  • [CommentIn] Pediatr Pulmonol. 2010 Jan;45(1):103; author reply 104 [19960525.001]
  • (PMID = 19061226.001).
  • [ISSN] 1099-0496
  • [Journal-full-title] Pediatric pulmonology
  • [ISO-abbreviation] Pediatr. Pulmonol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 94
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100. Luo BJ, Lü PX, Zhou XH, Pan JS: [CT image features of 46 cases with pneumonic-type lung cancers]. Zhonghua Zhong Liu Za Zhi; 2007 Nov;29(11):860-3
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  • [Title] [CT image features of 46 cases with pneumonic-type lung cancers].
  • OBJECTIVE: To analyze the CT image features of pneumonic-type lung cancer and to reduce misdiagnosis.
  • METHODS: The CT findings of 46 patients with pneumonic-type lung cancer were retrospectively reviewed, and CT image in the differential diagnosis of this special kind of disease was evaluated.
  • CONCLUSION: CT findings including lower lobe distribution, homogeneous consolidation, narrow air bronchogram, well defined ground-glass and CT angiogram are helpful in differentiating pneumonic-type lung cancer from various kinds of infection.
  • However, most of CT manifestations of pneumonic-type lung cancer are not specific.
  • Therefore, it's necessary to combine CT findings with other clinical data when making diagnosis.
  • [MeSH-major] Adenocarcinoma / radiography. Diagnostic Errors. Lung Neoplasms / radiography. Pneumonia, Bacterial / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / radiography. Adenocarcinoma, Mucinous / radiography. Adenocarcinoma, Papillary / radiography. Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lung / radiography. Male. Middle Aged. Radiographic Image Enhancement. Tuberculosis, Pulmonary / radiography

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  • (PMID = 18396648.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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