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1. Sugihara M, Hufen J, Buss V: Origin and consequences of steric strain in the rhodopsin binding pocket. Biochemistry; 2006 Jan 24;45(3):801-10
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  • To study the origin and the effects of steric strain on the chromophore conformation in rhodopsin, we have performed quantum-mechanical calculations on the wild-type retinal chromophore and four retinal derivatives, 13-demethyl-, 10-methyl-13-demethyl-, 10-methyl-, and 9-demethylretinal.
  • As a result, the polyene chain, from N16 to C13, is twisted in a clockwise manner against the remaining part of the chromophore, leading to a C11=C12 bond with the observed negative dihedral angle.
  • Shifts of the absorption maxima are reproduced correctly, in particular, the red shift of the 10-methyl and the strong blue shift of the 9-demethyl analogue relative to the wild type.
  • Calculated positive rotatory strengths of the alpha-CD bands are in agreement with the calculated absolute conformation of the mutant chromophores.

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  • (PMID = 16411756.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9009-81-8 / Rhodopsin
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2. Jiang XJ, Wang T, Li XY, Wu DQ, Zheng ZB, Zhang JF, Chen JL, Peng B, Jiang H, Huang C, Zhang XZ: Injection of a novel synthetic hydrogel preserves left ventricle function after myocardial infarction. J Biomed Mater Res A; 2009 Aug;90(2):472-7
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  • After 1 week, 200-microL alpha-cyclodextrin (alpha-CD)/MPEG-PCL-MPEG hydrogel was injected into the infarcted myocardium.
  • These results suggest that alpha-CD/MPEG-PCL-MPEG hydrogel could serve as an injectable biomaterial that prevents LV remodeling and dilation for the treatment of MI.

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  • (PMID = 18546187.001).
  • [ISSN] 1552-4965
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Hydrogels; 0 / Polyesters; 0 / methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol); 25852-47-5 / Hydrogel; 30IQX730WE / Polyethylene Glycols
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3. Fakhari AR, Nojavan S, Haghgoo S, Mohammadi A: Development of a stability-indicating CE assay for the determination of amlodipine enantiomers in commercial tablets. Electrophoresis; 2008 Nov;29(22):4583-92
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  • Several types of CD were evaluated and best results were obtained using a fused-silica capillary with phosphate running buffer (100 mM, pH 3.0) containing 5 mM hydroxypropyl-alpha-CD.

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  • (PMID = 18985664.001).
  • [ISSN] 1522-2683
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Buffers; 0 / Cyclodextrins; 0 / Tablets; 1J444QC288 / Amlodipine
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4. Hsueh YH, Huang JL, Tseng MC, Her GR: Sensitivity improvement of CE/ESI/MS analysis of gangliosides using a liquid-junction/low-flow interface. Electrophoresis; 2010 Apr;31(7):1138-43
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  • Specifically, alpha-CD, used to break up ganglioside micelle formation, was replaced with isopropyl alcohol.
  • [MeSH-minor] Borates / chemistry. Equipment Design. Sensitivity and Specificity. Sodium. alpha-Cyclodextrins / chemistry

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  • (PMID = 20209568.001).
  • [ISSN] 1522-2683
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Borates; 0 / Gangliosides; 0 / alpha-Cyclodextrins; 9NEZ333N27 / Sodium
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5. Song le X, Wang HM, Xu P, Yang Y, Zhang ZQ: Experimental and theoretical studies on the inclusion complexation of syringic acid with alpha-, beta-, gamma- and heptakis(2,6-di-O-methyl)-beta-cyclodextrin. Chem Pharm Bull (Tokyo); 2008 Apr;56(4):468-74
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  • [Title] Experimental and theoretical studies on the inclusion complexation of syringic acid with alpha-, beta-, gamma- and heptakis(2,6-di-O-methyl)-beta-cyclodextrin.
  • Intermolecular interactions of alpha-, beta-, gamma- and heptakis(2,6-di-O-methyl)-beta-cyclodextrin (CD) with syringic acid (Syr) in aqueous solution are investigated by fluorescence spectroscopy.
  • The association abilities of Syr with the CDs decrease in the order gamma->beta->alpha- approximately DMbeta-CD.
  • Based on the results of NMR experimental and theoretical PM3 calculations both in vacuo and in water, it is found that Syr stays near the wider rim of alpha-CD cavity.
  • Both the number of substituted groups (NSG) in a guest and the molar volume ratio of the guest to host cavity (MVR) play an important role in forming the CD supramolecular complexes of a homologous series of phenol derivatives, such as 2-methoxylphenol (2-Mop), eugenol (Eug) and Syr, i.e., an appropriate NSG or MVR in an inclusion system, such as in 2-Mop-alpha-CD, Eug-beta-CD and Syr-gamma-CD systems, can maximize the intermolecular interaction between host and guest.

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  • (PMID = 18379092.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Drug Carriers; 0 / Indicators and Reagents; 0 / Solutions; 632XD903SP / Gallic Acid; E390O181H5 / syringic acid
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6. Wu YL, Li J: Synthesis of supramolecular nanocapsules based on threading of multiple cyclodextrins over polymers on gold nanoparticles. Angew Chem Int Ed Engl; 2009;48(21):3842-5
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  • The CD's stuck: Poly(ethylene glycol) chains anchored onto gold nanoparticles (AuNPs) are threaded by multiple alpha-cyclodextrin (alpha-CD) rings to form a supramolecular outer layer composed of pseudopolyrotaxane columns perpendicular to the nanoparticle surface.
  • Capping the polymer ends confines alpha-CD on the nanoparticle surface, cross-linking the alpha-CD rings and then removing the AuNP cores produces supramolecular nanocapsules.

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  • (PMID = 19378311.001).
  • [ISSN] 1521-3773
  • [Journal-full-title] Angewandte Chemie (International ed. in English)
  • [ISO-abbreviation] Angew. Chem. Int. Ed. Engl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Cyclodextrins; 0 / Nanocapsules; 0 / Polymers; 7440-57-5 / Gold
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7. Pai RK, Snider WK, Starkey CR, Viswanatha D, Foucar MK, Wilson CS: Nonsecretory variant of immunoproliferative small intestinal disease: a case report with pathologic, immunophenotypic, and molecular findings. Arch Pathol Lab Med; 2005 Nov;129(11):1487-90
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  • [Title] Nonsecretory variant of immunoproliferative small intestinal disease: a case report with pathologic, immunophenotypic, and molecular findings.
  • We report a case of the nonsecretory variant of immunoproliferative small intestinal disease involving the distal small bowel and the mesenteric and retroperitoneal lymph nodes in a 19-year-old woman from Mexico.
  • This variant extranodal marginal zone B-cell lymphoma appeared similar in the different sites of involvement, with more interspersed large cells and greater plasmacytic differentiation present in intestinal specimens.
  • Characteristic lymphoepithelial lesions and follicular colonization were seen in intestinal and lymph node sections, respectively.
  • The neoplastic B cells were cytoplasmic immunoglobulin (Ig) A heavy-chain restricted and lacked surface and cytoplasmic light-chain expression by flow cytometric analysis.
  • Molecular studies showed absence of immunoglobulin heavy-chain (IgH) gene rearrangement, with a nonfunctional clonotypic rearrangement of the kappa light-chain gene.
  • This case highlights the role for kappa light-chain gene evaluation in immunoproliferative small intestinal disease, because IgH gene rearrangement analysis is often negative.
  • [MeSH-major] Immunoproliferative Small Intestinal Disease / pathology. Lymph Nodes / pathology. Lymphoma, B-Cell, Marginal Zone / pathology
  • [MeSH-minor] 2-Pyridinylmethylsulfinylbenzimidazoles. Adult. Amoxicillin / therapeutic use. Anti-Bacterial Agents / therapeutic use. Benzimidazoles / therapeutic use. Drug Therapy, Combination. Female. Gene Rearrangement, B-Lymphocyte, Light Chain / genetics. Humans. Immunophenotyping. Intestine, Small / pathology. Mesentery. Metronidazole / therapeutic use. Omeprazole / analogs & derivatives. Omeprazole / therapeutic use. Retroperitoneal Space. Sulfoxides / therapeutic use

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  • (PMID = 16253033.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-Pyridinylmethylsulfinylbenzimidazoles; 0 / Anti-Bacterial Agents; 0 / Benzimidazoles; 0 / Sulfoxides; 140QMO216E / Metronidazole; 804826J2HU / Amoxicillin; D8TST4O562 / pantoprazole; KG60484QX9 / Omeprazole
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8. Li X, Li J: Supramolecular hydrogels based on inclusion complexation between poly(ethylene oxide)-b-poly (epsilon-caprolactone) diblock copolymer and alpha-cyclodextrin and their controlled release property. J Biomed Mater Res A; 2008 Sep 15;86(4):1055-61
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  • [Title] Supramolecular hydrogels based on inclusion complexation between poly(ethylene oxide)-b-poly (epsilon-caprolactone) diblock copolymer and alpha-cyclodextrin and their controlled release property.
  • Supramolecular hydrogels formed through inclusion complexation between high molecular weight poly(ethylene oxide) (PEO) and alpha-cyclodextrin (alpha-CD) showed the most sustained release kinetics in vitro with molecular weight of PEO of 35,000 within 5 days.
  • Compared with that of alpha-CD/PEO supramolecular hydrogels, the sustained release of alpha-CD/PEO-PCL supramolecular hydrogel was increased significantly even if with much lower molecular weight of PEO block.
  • The sustained release is also dependent on the alpha-CD content in supramolecular hydrogels.
  • Thus, the properties of supramolecular hydrogel can be fine-tuned with different polymer and at different alpha-CD content, opening a wide range of applications.
  • [MeSH-major] Drug Delivery Systems. Hydrogels / chemistry. Lactones / chemistry. Polyethylene Glycols / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 18067162.001).
  • [ISSN] 1552-4965
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydrogels; 0 / Lactones; 0 / alpha-Cyclodextrins; 0 / poly(ethylene oxide)-b-poly(caprolactone); 30IQX730WE / Polyethylene Glycols; I223NX31W9 / Fluorescein-5-isothiocyanate; K3R6ZDH4DU / Dextrans; Z1LH97KTRM / alpha-cyclodextrin
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9. Yamauchi K, Miyawaki A, Takashima Y, Yamaguchi H, Harada A: Switching from altro-alpha-cyclodextrin dimer to pseudo[1]rotaxane dimer through tumbling. Org Lett; 2010 Mar 19;12(6):1284-6
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  • [Title] Switching from altro-alpha-cyclodextrin dimer to pseudo[1]rotaxane dimer through tumbling.
  • An alkyl altro-alpha-CD dimer was converted to the pseudo[1]rotaxane dimer through tumbling of the altropyranose unit of altro-alpha-CD in D(2)O.
  • The activation free energy (DeltaG(double dagger)(288K)) for the conformational change from an alkyl altro-alpha-CD dimer to pseudo[1]rotaxane dimer was 88.0 kJ mol(-1), which corresponds to the breakage of the hydrogen bond network for the tumbling of an altropyranose unit.
  • [MeSH-major] Rotaxanes / chemical synthesis. alpha-Cyclodextrins / chemistry

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  • (PMID = 20180513.001).
  • [ISSN] 1523-7052
  • [Journal-full-title] Organic letters
  • [ISO-abbreviation] Org. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Rotaxanes; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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10. Kim SK, Park IK, Park BH, Park W, Lee HS, Kim TH, Jun JB, Bae SC, Yoo DH, Uhm WS: A case report: isolated a heavy chain monoclonal gammopathy in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin change syndrome. Int J Clin Pract Suppl; 2005 Apr;(147):26-30
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  • [Title] A case report: isolated a heavy chain monoclonal gammopathy in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin change syndrome.
  • A 45-year-old South-Korean man presented with abdominal distension, progressive paresthesia and motor weakness of both lower extremities.
  • Circulating M components of POEMS syndrome consist mainly of IgG or IgA-lambda and rarely IgM-lambda, IgG-kappa or isolated light chains.
  • In this case, the M-band on serum protein electrophoresis and isolated IgA heavy chain on serum immunofixation electrophoresis were demonstrated, but there was no abnormal light chain.
  • We suggest that this case may be associated with a pattern of abnormal secretion of monoclonal protein or a coincidence of a heavy chain disease in POEMS syndrome, even though the latter possibility may be very rare.
  • [MeSH-major] Heavy Chain Disease / diagnosis. POEMS Syndrome / diagnosis
  • [MeSH-minor] Bone Marrow / radionuclide imaging. Humans. Immunoglobulin A / blood. Immunoglobulin alpha-Chains / blood. Male. Middle Aged. Pleural Effusion / radiography. Pulmonary Atelectasis / radiography

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  • (PMID = 15875614.001).
  • [ISSN] 1368-504X
  • [Journal-full-title] International journal of clinical practice. Supplement
  • [ISO-abbreviation] Int J Clin Pract Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulin A; 0 / Immunoglobulin alpha-Chains
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11. Balan B, Gopidas KR: Photoinduced electron transfer in alpha-cyclodextrin-based supramolecular dyads: a free-energy-dependence study. Chemistry; 2006 Aug 25;12(25):6701-10
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  • [Title] Photoinduced electron transfer in alpha-cyclodextrin-based supramolecular dyads: a free-energy-dependence study.
  • Photoinduced electron transfer (PET) between alpha-cyclodextrin-appended pyrene (PYCD) and a few acceptor molecules was studied in aqueous solutions.
  • The pyrene moiety in PYCD is located above the narrower rim of the alpha-CD and is fully exposed to water.

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  • (PMID = 16800017.001).
  • [ISSN] 0947-6539
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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12. Liu J, Sondjaja HR, Tam KC: Alpha-cyclodextrin-induced self-assembly of a double-hydrophilic block copolymer in aqueous solution. Langmuir; 2007 Apr 24;23(9):5106-9
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  • [Title] Alpha-cyclodextrin-induced self-assembly of a double-hydrophilic block copolymer in aqueous solution.
  • Double-hydrophilic poly(ethylene oxide)-b-poly(acrylic acid) (PEO-b-PAA) self-assembled into nanostructures in basic solution upon the addition of alpha-cyclodextrin (alpha-CD) as a result of the complexation between alpha-CD and PEO.
  • The nanostructures produced were spherical in shape as observed by transmission electron microscopy (TEM) and possessed radii that were much larger than that of a single stretched polymeric chain.
  • The above results suggested that the nanostructures formed in the PEO-b-PAA/alpha-CD solution at high pH were likely to be spherical vesicles.

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  • (PMID = 17391053.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Baer AJ, Macartney DH: Orientational isomers of alpha-cyclodextrin [2]semi-rotaxanes with asymmetric dicationic threads. Org Biomol Chem; 2005 Apr 21;3(8):1448-52
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  • [Title] Orientational isomers of alpha-cyclodextrin [2]semi-rotaxanes with asymmetric dicationic threads.
  • Two series of novel dicationic threading molecules [Quin(CH2)10R]2+ and [3,5-Lut(CH2)10R]2+, where Quin+ = quinuclidinium, 3,5-Lut+ = 3,5-lutidinium, and R+ = N(CH3)3+ and N(CH3)2CH2CH3+, form [2]semi-rotaxanes with [small alpha]-cyclodextrin (alpha-CD) in aqueous solution.
  • The quinuclidinium and 3,5-lutidinium are sufficiently bulky to prevent threading while the R+ groups allow for slow threading by alpha-CD at 25 degrees C.
  • The resulting [2]semi-rotaxanes exist in two orientational isomers owing to the asymmetry of both the alpha-CD cavity and the threading molecules.

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  • (PMID = 15827640.001).
  • [ISSN] 1477-0520
  • [Journal-full-title] Organic & biomolecular chemistry
  • [ISO-abbreviation] Org. Biomol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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14. Berentsen S, Beiske K, Tjønnfjord GE: Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy. Hematology; 2007 Oct;12(5):361-70
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  • [Title] Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy.
  • Chronic cold agglutinin disease (CAD) is a subgroup of autoimmune hemolytic anemia.
  • Primary CAD has traditionally been defined by the absence of any underlying or associated disease.
  • The results of therapy with corticosteroids, alkylating agents and interferon-alpha have been poor.
  • These cold agglutinins are monoclonal, usually IgMkappa autoantibodies with heavy chain variable regions encoded by the V(H)4-34 gene segment.
  • By flowcytometric and immunohistochemical assessments, a monoclonal CD20+kappa+B-lymphocyte population has been demonstrated in the bone marrow of 90% of the patients, and lymphoplasmacytic lymphoma is a frequent finding.
  • In this review, we discuss the clinical and pathogenetic features of primary CAD, emphasizing the more recent data on its close association with clonal lymphoproliferative bone marrow disorders and implications for therapy.
  • [MeSH-minor] Adrenal Cortex Hormones / therapeutic use. Alkylating Agents / therapeutic use. Antibodies, Monoclonal / therapeutic use. Antibodies, Monoclonal, Murine-Derived. B-Lymphocytes / pathology. Bone Marrow / pathology. Clone Cells / pathology. Cryoglobulins / analysis. Cryoglobulins / immunology. Humans. Immunotherapy. Interferon-alpha / therapeutic use. Lymphoproliferative Disorders / complications. Lymphoproliferative Disorders / drug therapy. Lymphoproliferative Disorders / pathology. Rituximab

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  • (PMID = 17891600.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Alkylating Agents; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Cryoglobulins; 0 / Interferon-alpha; 0 / cold agglutinins; 4F4X42SYQ6 / Rituximab
  • [Number-of-references] 88
  • [Other-IDs] NLM/ PMC2409172
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15. Sekine H, Shimizu T, Yang J, Kobayashi E, Okano T: Pulsatile myocardial tubes fabricated with cell sheet engineering. Circulation; 2006 Jul 4;114(1 Suppl):I87-93
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  • METHODS AND RESULTS: Neonatal rat cardiomyocyte sheets were sequentially wrapped around a resected adult rat thoracic aorta and transplanted in place of the abdominal aorta of athymic rats (n=17).
  • Finally, when myocardial tubes used for aortic replacement were compared with grafts implanted in the abdominal cavity (n=7), we observed significantly increased tissue thickness, as well as expression of brain natriuretic peptide, myosin heavy chain-alpha, and myosin heavy chain-beta.
  • [MeSH-major] Aorta, Abdominal / surgery. Myocardial Contraction. Myocardium / cytology. Myocytes, Cardiac / transplantation. Tissue Engineering / methods
  • [MeSH-minor] Animals. Animals, Newborn. Aorta, Thoracic / transplantation. Cell Culture Techniques / instrumentation. Cells, Cultured / transplantation. Electrocardiography. Gene Expression Profiling. Microsurgery. Myosin Heavy Chains / biosynthesis. Myosin Heavy Chains / genetics. Natriuretic Peptide, Brain / biosynthesis. Natriuretic Peptide, Brain / genetics. Organ Culture Techniques. Rats. Rats, Nude. Rats, Wistar. Temperature

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  • (PMID = 16820651.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bmyo protein, rat; 0 / natriuretic peptide precursor type B, rat; 114471-18-0 / Natriuretic Peptide, Brain; EC 3.6.4.1 / Myosin Heavy Chains
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16. Kandoth N, Choudhury SD, Mukherjee T, Pal H: Host-guest interaction of 1,4-dihydroxy-9,10-anthraquinone (quinizarin) with cyclodextrins. Photochem Photobiol Sci; 2009 Jan;8(1):82-90
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  • The interaction of 1,4-dihydroxy-9,10-anthraquinone, (quinizarin; QZ), with alpha-, beta- and gamma-cyclodextrin (CD) hosts, has been investigated using absorption, and steady-state and time-resolved fluorescence measurements, in order to understand the effects of cavity size of CDs on the binding of QZ molecule and the changes in the photophysical properties of QZ in the microenvironment of the hosts.
  • It is proposed that the unsubstituted benzene ring of QZ is encapsulated within alpha- and beta-CD cavities whereas the dihydroxy-substituted aromatic ring is encapsulated within the gamma-CD cavity.
  • It is observed that the complexation of QZ with the metal ion is enhanced in the QZ.alpha-CD and QZ.beta-CD systems whereas it is significantly reduced in the QZ.gamma-CD system, due to shielding of the chelating groups of the dye inside the CD cavity in the latter case.

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  • (PMID = 19247534.001).
  • [ISSN] 1474-905X
  • [Journal-full-title] Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • [ISO-abbreviation] Photochem. Photobiol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthraquinones; 0 / Cyclodextrins; 8S496ZV3CS / 1,4-dihydroxyanthraquinone
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17. Paau MC, Lo CK, Yang X, Choi MM: Capillary electrophoretic study of thiolated alpha-cyclodextrin-capped gold nanoparticles with tetraalkylammonium ions. J Chromatogr A; 2009 Nov 27;1216(48):8557-62
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  • [Title] Capillary electrophoretic study of thiolated alpha-cyclodextrin-capped gold nanoparticles with tetraalkylammonium ions.
  • Capillary zone electrophoresis (CZE) has been employed to characterize nanometer-sized thiolated alpha-cyclodextrin-capped gold nanoparticles (alpha-CD-S-AuNPs).
  • The addition of tetrabutylammonium (Bu(4)N(+)) ions to the run buffer greatly narrows the migration peak of alpha-CD-S-AuNP.
  • The effect of various tetraalkylammonium ions on the peak width and electrophoretic mobility (mu(e)) of alpha-CD-S-AuNP was studied in detail.
  • Bu(4)N(+) ions assist in inter-linking the alpha-CD-S-AuNPs and narrowing the migration peak in CZE.
  • This observation can be explained by the fact that each Bu(4)N(+) ion can simultaneously interact with several hydrophobic cavities of the surface-attached alpha-CDs on AuNPs.
  • The TEM images show that alpha-CD-S-AuNPs with Bu(4)N(+) are linked together but in the absence of Bu(4)N(+), they are more dispersed.
  • The migration mechanism in CZE is based on the formation of inclusion complexes between Bu(4)N(+) and alpha-CD-S-AuNPs which induces changes in the charge-to-size ratio of alpha-CD-S-AuNPs and mu(e).
  • An inverse linear relationship (r(2)>0.998) exists between the mu(e) and size of alpha-CD-S-AuNPs in the core range 1.4-4.1 nm.
  • A few nanoliters of each of the alpha-CD-S-AuNP samples were injected hydrodynamically at 0.5 psi for 5s.
  • Our work confirms that CZE is an efficient tool for characterizing the sizes of alpha-CD-S-AuNPs using Bu(4)N(+) ions.
  • [MeSH-major] Electrophoresis, Capillary / methods. Gold / chemistry. Metal Nanoparticles / chemistry. Quaternary Ammonium Compounds / chemistry. Sulfhydryl Compounds / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 19853853.001).
  • [ISSN] 1873-3778
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Buffers; 0 / Ions; 0 / Quaternary Ammonium Compounds; 0 / Sulfhydryl Compounds; 0 / alpha-Cyclodextrins; 7440-57-5 / Gold; CBU2X6BBJR / tetrabutylammonium; Z1LH97KTRM / alpha-cyclodextrin
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18. Yazdanparast R, Esmaeili MA, Khodagholi F: Control of aggregation in protein refolding: cooperative effects of artificial chaperone and cold temperature. Int J Biol Macromol; 2007 Jan 30;40(2):126-33
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  • In both techniques, it was found that CTAB is a better additive (in dilution mode) or a capturing agent (in artificial chaperone method).
  • In dilution, using CTAB or alpha-cyclodextrin (alpha-CD) as two different additives, the aggregation was inhibited by almost 55%.
  • However, the extent of inhibition raised to almost 82% in artificial chaperone assisted mode using CTAB as the capturing and alpha-CD as the stripping agents.
  • [MeSH-minor] Guanidine / pharmacology. Humans. Protein Denaturation. Protein Renaturation. alpha-Cyclodextrins / pharmacology

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  • (PMID = 16875728.001).
  • [ISSN] 0141-8130
  • [Journal-full-title] International journal of biological macromolecules
  • [ISO-abbreviation] Int. J. Biol. Macromol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cetrimonium Compounds; 0 / alpha-Cyclodextrins; 9002-72-6 / Growth Hormone; JU58VJ6Y3B / Guanidine; Z1LH97KTRM / alpha-cyclodextrin; Z7FF1XKL7A / cetrimonium
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19. Yamagaki T, Sato A: Peak width-mass correlation in CID MS/MS of isomeric oligosaccharides using traveling-wave ion mobility mass spectrometry. J Mass Spectrom; 2009 Oct;44(10):1509-17
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  • The twIM peak width (ms-micros) of the product ions [M-Glc(n) + H]+ (n = 0-6) of gamma-CD correlated linearly with their masses (Da); the large and/or long chain product ions had wider peak widths, which were much wider than those from the general diffusion effect.

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  • [Copyright] Copyright 2009 John Wiley & Sons, Ltd.
  • (PMID = 19753613.001).
  • [ISSN] 1096-9888
  • [Journal-full-title] Journal of mass spectrometry : JMS
  • [ISO-abbreviation] J Mass Spectrom
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Oligosaccharides
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20. López-Nicolás JM, Andreu-Sevilla AJ, Carbonell-Barrachina AA, García-Carmona F: Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice. J Agric Food Chem; 2009 Oct 28;57(20):9668-75
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  • [Title] Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice.
  • Even though the addition of alpha-CD had a significant effect on both the concentration of individual volatile compounds and their grouping, only the highest concentration, 90 mM, prevented the oxidation of the volatile precursors present in freshly squeezed juice.
  • The addition of alpha-CD at 90 mM resulted in pear juices with the best color but with low aromatic intensity and low sensory quality.
  • On the other hand, the addition of alpha-CD at 15 mM led to a pear juice also with an acceptable color but at the same time with a high intensity of fruity and pear-like odors/aromas, making it the best appreciated juice by the panel.
  • [MeSH-major] Beverages / analysis. Food Additives / pharmacology. Pigmentation / drug effects. Pyrus / chemistry. Taste / drug effects. Volatile Organic Compounds / analysis. alpha-Cyclodextrins / pharmacology

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  • (PMID = 19799384.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Food Additives; 0 / Volatile Organic Compounds; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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21. Stratigos P, Kouskos E, Kouroglou M, Chrisafis I, Fois L, Mavrogiorgis A, Axiotis E, Zamtrakis S: Emergency pancreatoduodenectomy (whipple procedure) for massive upper gastrointestinal bleeding caused by a diffuse B-cell lymphoma of the duodenum: report of a case. Surg Today; 2007;37(8):680-4
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  • [Title] Emergency pancreatoduodenectomy (whipple procedure) for massive upper gastrointestinal bleeding caused by a diffuse B-cell lymphoma of the duodenum: report of a case.
  • We herein report a rare case of a massive upper gastrointestinal (GI) bleeding, caused by high-grade diffuse B-cell lymphoma of the duodenum, secondary to immunoproliferative small intestinal disease (IPSID) and treated with an emergency partial pancreatoduodenectomy.
  • An urgent abdominal ultrasound raised the suspicion of a large, possibly bleeding, neoplasm of the duodenum, which was finally confirmed by abdominal computed tomography.
  • Histologically, the tumor was a high-grade B-cell lymphoma of the duodenum.
  • The nearby small intestinal mucosa was suggestive of IPSID.
  • A massive upper GI hemorrhage from a high-grade B-cell non-Hodgkin lymphoma of the duodenum, which develops secondary to IPSID, is a very rare clinical demonstration of this disease.
  • [MeSH-major] Duodenal Neoplasms / complications. Emergency Treatment. Gastrointestinal Hemorrhage / surgery. Lymphoma, B-Cell / complications. Pancreaticoduodenectomy / methods. Upper Gastrointestinal Tract / surgery
  • [MeSH-minor] Humans. Immunoproliferative Small Intestinal Disease

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  • (PMID = 17643214.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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22. Zhu W, Li Y, Liu L, Chen Y, Wang C, Xi F: Supramolecular hydrogels from cisplatin-loaded block copolymer nanoparticles and α-cyclodextrins with a stepwise delivery property. Biomacromolecules; 2010 Nov 8;11(11):3086-92
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  • [MeSH-major] Acrylic Resins / chemistry. Antineoplastic Agents / pharmacology. Cisplatin / pharmacology. Drug Delivery Systems. Hydrogels / chemistry. Polyethylene Glycols / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 20958000.001).
  • [ISSN] 1526-4602
  • [Journal-full-title] Biomacromolecules
  • [ISO-abbreviation] Biomacromolecules
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / Antineoplastic Agents; 0 / Hydrogels; 0 / Macromolecular Substances; 0 / Micelles; 0 / alpha-Cyclodextrins; 30IQX730WE / Polyethylene Glycols; 9003-01-4 / carbopol 940; Q20Q21Q62J / Cisplatin
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23. Ferrer M, Beloqui A, Golyshina OV, Plou FJ, Neef A, Chernikova TN, Fernández-Arrojo L, Ghazi I, Ballesteros A, Elborough K, Timmis KN, Golyshin PN: Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome. Biotechnol J; 2007 Feb;2(2):207-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A novel enzyme, RA.04, belonging to the alpha-amylase family was obtained after expression of metagenomic DNA from rumen fluid (Ferrer et al.: Environ. Microbiol.
  • The enzyme hydrolyzed alpha-D-(1,4) bonds 13-fold faster than alpha-D-(1,6) bonds to yield maltose and glucose as the main products, and it exhibited transglycosylation activity.
  • Its preferred substrates, in the descending order, were maltooligosaccharides (C3-C7), cyclomaltoheptaose (beta-CD), cyclomaltohexaose (alpha-CD), cyclomaltooctaose (gamma-CD), soluble starch, amylose, pullulan and amylopectin.
  • [MeSH-minor] Amylopectin / metabolism. Amylose / metabolism. Animals. Binding Sites. Catalysis. Cattle. Chromatography, High Pressure Liquid. Electrophoresis, Polyacrylamide Gel. Glucans / metabolism. Hydrogen-Ion Concentration. Maltose / metabolism. Oligosaccharides / metabolism. Starch / metabolism. Substrate Specificity. Temperature. alpha-Cyclodextrins / metabolism. beta-Cyclodextrins / metabolism. gamma-Cyclodextrins / metabolism

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  • (PMID = 17238236.001).
  • [ISSN] 1860-7314
  • [Journal-full-title] Biotechnology journal
  • [ISO-abbreviation] Biotechnol J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Glucans; 0 / Oligosaccharides; 0 / alpha-Cyclodextrins; 0 / beta-Cyclodextrins; 0 / gamma-Cyclodextrins; 0 / maltooligosaccharides; 69-79-4 / Maltose; 8ZQ0AYU1TT / pullulan; 9005-25-8 / Starch; 9005-82-7 / Amylose; 9037-22-3 / Amylopectin; EC 3.2.1.- / Glycoside Hydrolases; EC 3.2.1.54 / cyclomaltodextrinase; JV039JZZ3A / betadex; KZJ0BYZ5VA / gamma-cyclodextrin; Z1LH97KTRM / alpha-cyclodextrin
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24. Danel C, Chaminade P, Odou P, Bartélémy C, Azarzar D, Bonte JP, Vaccher C: Enantioselective analysis of the antipsychotic 9-hydroxyrisperidone, main metabolite of risperidone, by chiral capillary EKC using dual CDs. Electrophoresis; 2007 Aug;28(15):2683-92
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  • Preliminary experiments allowed us to select the more suitable couple of CDs composed of sulfated-alpha-CD and hydroxypropylated-beta-CD.

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  • (PMID = 17600845.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Isoxazoles; 0 / Pyrimidines; 0 / beta-Cyclodextrins; L6UH7ZF8HC / Risperidone; R8P8USM8FR / Paliperidone Palmitate
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25. Figueiredo KM, Marcon RO, Campos IB, Nantes IL, Brochsztain S: Photoinduced electron transfer between cytochrome c and a novel 1,4,5,8-naphthalenetetracarboxylic diimide with amphiphilic character. J Photochem Photobiol B; 2005 Apr 4;79(1):1-9
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  • DNDI formed host-guest complexes with alpha-cyclodextrin (alpha-CD) through the inclusion of the dodecyl group, resulting in an increased aqueous solubility of the compound.

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  • (PMID = 15792874.001).
  • [ISSN] 1011-1344
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / 1,4,5,8-naphthalenetetracarboxylic diimide; 0 / Imides; 0 / Micelles; 0 / Naphthalenes; 0 / Surface-Active Agents; 42VZT0U6YR / Heme; 9007-43-6 / Cytochromes c
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26. Ooya T, Inoue D, Choi HS, Kobayashi Y, Loethen S, Thompson DH, Ko YH, Kim K, Yui N: pH-responsive movement of cucurbit[7]uril in a diblock polypseudorotaxane containing dimethyl beta-cyclodextrin and cucurbit[7]uril. Org Lett; 2006 Jul 20;8(15):3159-62
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  • [Structure: see text] A polypseudorotaxane consisting of cucurbit[7]uril (CB[7])/N,N'-(3-phenylenebis(methylene)dipropargylamine (PMPA), [2]pseudorotaxane, and 2,6-O-dimethyl beta-cyclodextrin (DM-beta-CD)/alpha,omega-bisazidopropylene glycol 400 [2]pseudorotaxane was synthesized using the "click" reaction.

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  • (PMID = 16836355.001).
  • [ISSN] 1523-7060
  • [Journal-full-title] Organic letters
  • [ISO-abbreviation] Org. Lett.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM055266; United States / NIDCR NIH HHS / DE / DE13030
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bridged Compounds; 0 / Cyclodextrins; 0 / Imidazoles; 0 / Rotaxanes; 0 / cucurbit(7)uril
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27. Chen CY, Chen CC, Chung YC: Removal of phthalate esters by alpha-cyclodextrin-linked chitosan bead. Bioresour Technol; 2007 Sep;98(13):2578-83
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  • [Title] Removal of phthalate esters by alpha-cyclodextrin-linked chitosan bead.
  • Removal of phthalate esters (PAEs) by alpha-cyclodextrin (CD)-linked chitosan bead in aqueous solution was studied.
  • DHpP recovery was 94.6% from alpha-CD-linked chitosan bead by shaking both with a mixture of methanol and water (v/v = 8/2).
  • The recovered alpha-CD chitosan bead was reusable as an adsorbent 20 times in the batch tests.
  • The adsorbed PAE by alpha-CD-linked chitosan bead decreased as temperature increased.
  • It was concluded that the application of low cost alpha-CD-linked chitosan bead could have the potential to effectively remove PAEs from different aquatic environments.
  • [MeSH-major] Chitosan / chemistry. Phthalic Acids / isolation & purification. alpha-Cyclodextrins / chemistry

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  • (PMID = 17070038.001).
  • [ISSN] 0960-8524
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Esters; 0 / Phthalic Acids; 0 / alpha-Cyclodextrins; 451W47IQ8X / Sodium Chloride; 9012-76-4 / Chitosan; SY7Q814VUP / Calcium; Z1LH97KTRM / alpha-cyclodextrin
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28. Taira T, Suzaki Y, Osakada K: Hydrogels composed of organic amphiphiles and alpha-cyclodextrin: supramolecular networks of their pseudorotaxanes in aqueous media. Chemistry; 2010 Jun 11;16(22):6518-29
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  • [Title] Hydrogels composed of organic amphiphiles and alpha-cyclodextrin: supramolecular networks of their pseudorotaxanes in aqueous media.
  • Mixtures of N-alkyl pyridinium compounds [py-N-(CH(2))(n)OC(6)H(3)-3,5-(OMe)(2)](+)(X(-)) (1bCl: n = 10, X = Cl; 1cBr: n = 12, X = Br) and alpha-cyclodextrin (alpha-CD) form supramolecular hydrogels in aqueous media.
  • Washing the hydrogel with acetone or evaporation of water left the xerogel, and (13)C CP/MAS NMR measurements, powder X-ray diffraction (XRD), and scanning electron microscopy (SEM) revealed that the xerogel of 1bCl (or 1cBr) and alpha-CD was composed of pseudorotaxanes with high crystallinity. (13)C{(1)H} and (1)H NMR spectra of the gel revealed the detailed composition of the components.
  • The gel from 1bCl and alpha-CD contains the corresponding [2]- and [3]pseudorotaxanes, [1b x (alpha-CD)]Br and [1b x (alpha-CD)(2)]Br, while that from 1cBr and alpha-CD consists mainly of [3]pseudorotaxane [1c x (alpha-CD)(2)]Br.
  • Thus, intermolecular interaction between the end groups of the axle component and that between alpha-CDs of the [3]pseudorotaxane contribute to formation of the network.
  • The supramolecular gels were transformed into sols by adding denaturing agents such as urea, C(6)H(3)-1,3,5-(OH)(3), and [py-N-nBu](+)(Cl(-)).

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  • (PMID = 20411534.001).
  • [ISSN] 1521-3765
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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29. Fu GD, Xu LQ, Yao F, Li GL, Kang ET: Smart nanofibers with a photoresponsive surface for controlled release. ACS Appl Mater Interfaces; 2009 Nov;1(11):2424-7
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  • A novel photocontrolled "ON-OFF" release system for the alpha-cyclodextrin-5-fluorouracial (alpha-CD-5FU) prodrug, based on host-guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated.
  • [MeSH-major] Light. Nanofibers / chemistry. alpha-Cyclodextrins / pharmacology

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  • (PMID = 20356110.001).
  • [ISSN] 1944-8244
  • [Journal-full-title] ACS applied materials & interfaces
  • [ISO-abbreviation] ACS Appl Mater Interfaces
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Delayed-Action Preparations; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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30. Ommen HB, Schnittger S, Jovanovic JV, Ommen IB, Hasle H, Østergaard M, Grimwade D, Hokland P: Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias. Blood; 2010 Jan 14;115(2):198-205
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  • Early relapse detection in acute myeloid leukemia is possible using standardized real-time quantitative polymerase chain reaction (RQ-PCR) protocols.
  • Furthermore, we used a mathematical model to determine frequency of relapse detection and median time from detection of minimal residual disease to hematologic relapse as a function of sampling interval length.
  • These data carry important implications for the development of optimal RQ-PCR monitoring schedules suitable for evaluation of minimal residual disease-directed therapies in future clinical trials.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Core Binding Factor Alpha 2 Subunit / biosynthesis. Core Binding Factor beta Subunit / biosynthesis. Gene Expression Regulation, Leukemic. Leukemia, Myeloid, Acute / metabolism. Myosin Heavy Chains / biosynthesis. Nuclear Proteins / biosynthesis. Oncogene Proteins, Fusion / biosynthesis

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  • (PMID = 19901261.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AML1-ETO fusion protein, human; 0 / Biomarkers, Tumor; 0 / CBFB protein, human; 0 / Core Binding Factor Alpha 2 Subunit; 0 / Core Binding Factor beta Subunit; 0 / MYH11 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; 117896-08-9 / nucleophosmin; EC 3.6.4.1 / Myosin Heavy Chains
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31. Trapani A, Lopedota A, Franco M, Cioffi N, Ieva E, Garcia-Fuentes M, Alonso MJ: A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides. Eur J Pharm Biopharm; 2010 May;75(1):26-32
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  • [Title] A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides.
  • More precisely, NP formulations composed of CS, CS/alpha-CD and CS/sulphobutyl ether-beta-cyclodextrin (SBE(7m)-beta-CD) were investigated for this application.
  • Transport studies performed in the frog intestine model confirmed that both CS and CS/CD nanoparticles could induce permeabilization of the intestinal epithelia.
  • From the data obtained, we believe that CS/CD nanoparticles might represent an interesting technological platform for the oral administration of small peptides.
  • [MeSH-minor] Administration, Oral. Animals. Chitosan. Intestinal Absorption / drug effects. Intestinal Absorption / physiology. Rana esculenta

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  • (PMID = 20102738.001).
  • [ISSN] 1873-3441
  • [Journal-full-title] European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
  • [ISO-abbreviation] Eur J Pharm Biopharm
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Drug Carriers; 0 / Peptide Fragments; 9012-76-4 / Chitosan; GAN16C9B8O / Glutathione
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32. Plazanet M, Dean M, Merlini M, Hüller A, Emerich H, Meneghini C, Johnson MR, Trommsdorff HP: Crystallization on heating and complex phase behavior of alpha-cyclodextrin solutions. J Chem Phys; 2006 Oct 21;125(15):154504
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  • [Title] Crystallization on heating and complex phase behavior of alpha-cyclodextrin solutions.
  • Solutions composed of alpha-cyclodextrin (alpha-CD), water, and various methylpyridines, in particular, 4-methylpyridine (4MP), undergo reversible liquid-solid transitions upon heating, the crystalline solid phases undergoing further phase transformations at higher temperatures.
  • For the alpha-CD/4MP system five crystalline phases have been identified.
  • A simple model is proposed that mimics the observed disorder-order transition.

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  • (PMID = 17059269.001).
  • [ISSN] 0021-9606
  • [Journal-full-title] The Journal of chemical physics
  • [ISO-abbreviation] J Chem Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Taira T, Suzaki Y, Osakada K: Thermosensitive hydrogels composed of cyclodextrin pseudorotaxanes. Role of [3]pseudorotaxane in the gel formation. Chem Commun (Camb); 2009 Dec 7;(45):7027-9
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  • Pseudorotaxanes composed of an alkylpyridinium and alpha-cyclodextrin (alpha-CD) form supramolecular hydrogels which show sol-gel transitions at 7-67 degrees C depending on the type and amount of the guest compound.

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  • (PMID = 19904383.001).
  • [ISSN] 1364-548X
  • [Journal-full-title] Chemical communications (Cambridge, England)
  • [ISO-abbreviation] Chem. Commun. (Camb.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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34. Yu Y, Cai W, Chipot C, Sun T, Shao X: Spatial arrangement of alpha-cyclodextrins in a rotaxane. Insights from free-energy calculations. J Phys Chem B; 2008 May 1;112(17):5268-71
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  • [Title] Spatial arrangement of alpha-cyclodextrins in a rotaxane. Insights from free-energy calculations.
  • The rotaxane formed by alpha-cyclodextrins (alpha-CDs) threaded onto a poly(ethylene glycol) (PEG) chain was investigated in the gas phase and in an aqueous solution by means of molecular dynamics simulations.
  • The free-energy difference between the three possible spatial arrangements of consecutive alpha-CD--viz.. head-to-head (HH), head-to-tail (HT), and tail-to-tail, was determined using free-energy perturbation calculations.
  • These simulations reveal that the interaction of alpha-CD with the PEG chain is very similar in the two surroundings, whereas the mutual interaction of the macrocycles is stronger in the gas phase than in the aqueous solution.
  • Analysis of intermolecular hydrogen bonds indicates that hydrogen bonds created between alpha-CD and water molecules weaken the hydrogen-bonding interaction of adjacent alpha-CDs.
  • Comparison of the free-energy differences characteristic of the three possible spatial arrangements of contiguous alpha-CDs reveals that the HH motif of the rotaxane is the most stable in the gas phase due to the hydrogen-bond formation between the secondary hydroxyl groups of the two alpha-CDs, and the slight preference for the HT motif in aqueous solution, which can be related to the directionality of the dipole moment borne by the macrocycles in these two motifs.

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  • (PMID = 18393550.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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35. Ishikawa S, Hirota S, Neya S, Funasaki N: Molecular motions of alpha-cyclodextrin on a dodecyl chain studied by molecular dynamics simulations. Chem Pharm Bull (Tokyo); 2006 Apr;54(4):528-34
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  • [Title] Molecular motions of alpha-cyclodextrin on a dodecyl chain studied by molecular dynamics simulations.
  • Motions of an alpha-cyclodextrin (alpha-CD) molecule on a dodecyl chain adopting the all-trans conformation were investigated in the presence of water by molecular dynamics simulations with CVFF force fields, where the trimethylammonium group of dodecyltrimethylammonium bromide (DTAB) is protruded outside the secondary hydroxyl rim of alpha-CD (the secondary-in structure).
  • The alpha-CD molecule shuttled rapidly on the chain without decomplexation.
  • The plane formed by 6 O4 atoms of alpha-CD is most populated between the C6 and C7 atoms of DTAB.
  • The alpha-CD molecule underwent a restricted rotation in a range of 60 degrees with regard to the plane of the dodecyl chain: this plane at the most population is middle between the two diagonal lines of the normal hexagon formed by 6 O4 atoms of alpha-CD.
  • The distortion of the alpha-CD cavity from the normal hexagon was decreased upon complex formation with DTAB.
  • The deviation of the center of alpha-CD from the center of the dodecyl chain predicted by molecular dynamics simulations is consistent with the NMR data.
  • [MeSH-major] Computer Simulation. Models, Molecular. Quaternary Ammonium Compounds / chemistry. Surface-Active Agents / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 16595958.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Quaternary Ammonium Compounds; 0 / Surface-Active Agents; 0 / alpha-Cyclodextrins; 10182-91-9 / dodecyltrimethylammonium; Z1LH97KTRM / alpha-cyclodextrin
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36. Miyauchi M, Takashima Y, Yamaguchi H, Harada A: Chiral supramolecular polymers formed by host-guest interactions. J Am Chem Soc; 2005 Mar 9;127(9):2984-9
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  • alpha-Cyclodextrin with a p-t-butoxyaminocinnamoylamino group in the 3-position (3-p-(t)()BocCiNH-alpha-CD) has been found to form a supramolecular polymer in an aqueous solution.

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  • (PMID = 15740135.001).
  • [ISSN] 0002-7863
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Machado MV, Martins A, Almeida R, Marques-Vidal P, Gonçalves MS, Camilo ME, Cortez-Pinto H: Does the simultaneous tumor necrosis factor receptor 2, tumor necrosis factor promoter gene polymorphism represent a higher risk for alcoholic liver disease? Eur J Gastroenterol Hepatol; 2009 Feb;21(2):201-5
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  • [Title] Does the simultaneous tumor necrosis factor receptor 2, tumor necrosis factor promoter gene polymorphism represent a higher risk for alcoholic liver disease?
  • BACKGROUND AND AIM: Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that seems to play a crucial role in the pathogenesis of alcoholic liver disease (ALD).
  • TNF-alpha exerts its effects by binding to specific receptors (TNFR); the polymorphism of TNFRII T587G has been associated with increased TNF apoptotic response and its presence may increase the risk to develop liver disease.
  • The aim of this study was to evaluate the prevalence of the TNF-alpha G238A promoter and TNFRII polymorphisms, individually or simultaneously, in ALD.
  • METHODS: TNF-alpha G238A and TNFRII T587G polymorphisms were studied in 103 unrelated patients with ALD (biopsy confirmed or clinical evidence) and in 76 heavy drinkers without liver disease (NLD).
  • Single nucleotide polymorphism gene was detected by a polymerase chain reaction-restriction fragment length polymorphisms method.
  • RESULTS: TNF-alpha G238A allele frequency was similar in both groups.
  • TNF-alpha G238A and TNFRII T587G were simultaneously present in six ALD patients and in none of NLD patients (P=0.04).
  • CONCLUSION: Although individually there was no association between TNFRII T587G or TNF-alpha G238A polymorphisms and ALD, this study suggests that the presence of both polymorphisms may enhance the susceptibility for ALD.
  • TNF-alpha G238A may increase TNF-alpha production, which when associated with TNFRII T587G, can further exacerbate TNF-alpha response leading to a greater risk of ALD.
  • [MeSH-major] Liver Diseases, Alcoholic / genetics. Polymorphism, Genetic. Receptors, Tumor Necrosis Factor, Type II / genetics. Tumor Necrosis Factor-alpha / genetics
  • [MeSH-minor] Adult. Female. Gene Frequency. Genetic Predisposition to Disease. Humans. Male. Middle Aged. Promoter Regions, Genetic / genetics

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  • (PMID = 19212208.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Tumor Necrosis Factor, Type II; 0 / Tumor Necrosis Factor-alpha
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38. Yamauchi K, Takashima Y, Hashidzume A, Yamaguchi H, Harada A: Switching between supramolecular dimer and nonthreaded supramolecular self-assembly of stilbene amide-alpha-cyclodextrin by photoirradiation. J Am Chem Soc; 2008 Apr 16;130(15):5024-5
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  • [Title] Switching between supramolecular dimer and nonthreaded supramolecular self-assembly of stilbene amide-alpha-cyclodextrin by photoirradiation.
  • 3-trans-Stilbene amide-alpha-cyclodextrin (3-trans-Sti-alpha-CD) formed a double-threaded dimer in aqueous solutions.
  • In contrast, the photoisomerization of the stilbene moiety in 3-Sti-alpha-CD from trans to cis leads to the structural changes from the double-threaded dimer to nonthreaded supramolecular assemblies in aqueous solutions.
  • [MeSH-major] Amides / chemistry. Stilbenes / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 18335989.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amides; 0 / Stilbenes; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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39. Travelet C, Schlatter G, Hébraud P, Brochon C, Lapp A, Hadziioannou G: Formation and self-organization kinetics of alpha-CD/PEO-based pseudo-polyrotaxanes in water. A specific behavior at 30 degrees C. Langmuir; 2009 Aug 4;25(15):8723-34
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  • [Title] Formation and self-organization kinetics of alpha-CD/PEO-based pseudo-polyrotaxanes in water. A specific behavior at 30 degrees C.
  • alpha-Cyclodextrins (alpha-CDs) have the ability to form inclusion complexes with poly(ethylene oxide) (PEO) polymer chains.
  • These pseudo-polyrotaxanes (PPRs) can be obtained by quenching an alpha-CD/PEO mixture in water from 70 degrees C down to a lower temperature (typically in the range from 5 to 30 degrees C) thanks to favorable interactions between alpha-CD cavities and PEO chains.
  • Moreover, starting from a liquid alpha-CD/PEO mixture at a total mass fraction of 15% w/w at 70 degrees C, the formation of PPRs with time at a lower temperature induces a white physical gel with time, and phase separation is observed.
  • We established that PPR molecules are exclusively found in the precipitated phase although unthreaded alpha-CD molecules and unthreaded PEO chains are in the liquid phase.
  • At 30 degrees C, we established that, in a first step, alpha-CDs thread onto PEO chains, forming PPR molecules which are not in good solvent conditions in water.
  • At a higher length scale, rapid aggregation of the PPR molecules occurs, and threaded alpha-CD-based nanocylinders form (cylinder length L = 5.7 nm and cylinder radius R = 4.7 nm).
  • At a higher length scale, alpha-CD-based nanocylinders associate in a Gaussian way, engendering the formation of precipitated domains which are responsible for the high turbidity of the studied system.
  • [MeSH-major] Taxoids / chemical synthesis. Taxoids / chemistry. Water / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 19301842.001).
  • [ISSN] 1520-5827
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polymers; 0 / Taxoids; 0 / alpha-Cyclodextrins; 059QF0KO0R / Water; 30IQX730WE / Polyethylene Glycols; Z1LH97KTRM / alpha-cyclodextrin
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40. Lecuit M, Lortholary O: [Immunoproliferative small intestinal disease associated with Campylobacter jejuni]. Med Mal Infect; 2005 Jun;35 Suppl 2:S56-8
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  • [Title] [Immunoproliferative small intestinal disease associated with Campylobacter jejuni].
  • [Transliterated title] Maladie immunoproliférative de l'intestin grêle associée à Campylobacter jejuni.
  • [MeSH-major] Campylobacter Infections / complications. Intestinal Diseases / microbiology. Lymphoma, B-Cell, Marginal Zone / microbiology

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  • (PMID = 15978389.001).
  • [ISSN] 0399-077X
  • [Journal-full-title] Médecine et maladies infectieuses
  • [ISO-abbreviation] Med Mal Infect
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] France
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41. Hernández-Pascacio J, Garza C, Banquy X, Díaz-Vergara N, Amigo A, Ramos S, Castillo R, Costas M, Piñeiro A: Cyclodextrin-based self-assembled nanotubes at the water/air interface. J Phys Chem B; 2007 Nov 8;111(44):12625-30
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  • Native alpha-cyclodextrin (alpha-CD) is found to spontaneously form films at aqueous solution/air interfaces.
  • By using isothermal titration calorimetry (ITC), Brewster angle microscopy (BAM), atomic force microscopy (AFM), and molecular dynamics (MD) simulations, it is shown that the films consist of self-assembled nanotubes whose building blocks are cyclodextrin dimers (alpha-CD2) and alpha-CD2-SDS1 complexes.

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  • (PMID = 17941668.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Solutions; 059QF0KO0R / Water; 368GB5141J / Sodium Dodecyl Sulfate
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42. Lammers I, Buijs J, Ariese F, Gooijer C: Sensitized enantioselective laser-induced phosphorescence detection in chiral capillary electrophoresis. Anal Chem; 2010 Nov 15;82(22):9410-7
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  • Excitation was performed at 266 nm with a pulsed, small-sized, quadrupled Nd:YAG laser.

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  • (PMID = 20964317.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Resins, Synthetic; 76-22-2 / Camphor; RAL3591W33 / camphorquinone
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43. Jiang X, Ren YP, Lv ZR: Ouabain induces cardiac remodeling in rats independent of blood pressure. Acta Pharmacol Sin; 2007 Mar;28(3):344-52
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  • After 4 and 6 weeks, echocardiography were performed, hemodynamic parameters were measured by invasive cardiac catheterization, changes in cardiac ultrastructure were analyzed using transmission electron microscopy, the collagen fraction of the left ventricle was assessed with Picrosirius red stain, and RT-PCR was applied to evaluate the mRNA level of myosin heavy chain-alpha and -beta in the left ventricle.
  • Moreover, the cardiac MHC-beta mRNA was upregulated by ouabain treatment, whereas MHC-alpha mRNA was downregulated.
  • [MeSH-minor] Animals. Echocardiography. Glyceraldehyde-3-Phosphate Dehydrogenases / biosynthesis. Glyceraldehyde-3-Phosphate Dehydrogenases / genetics. Male. Myosin Heavy Chains / biosynthesis. Myosin Heavy Chains / genetics. Rats. Rats, Sprague-Dawley. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17302996.001).
  • [ISSN] 1671-4083
  • [Journal-full-title] Acta pharmacologica Sinica
  • [ISO-abbreviation] Acta Pharmacol. Sin.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cardiotonic Agents; 5ACL011P69 / Ouabain; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases; EC 3.6.4.1 / Myosin Heavy Chains
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44. Shaikh M, Mohanty J, Bhasikuttan AC, Pal H: Tuning dual emission behavior of p-dialkylaminobenzonitriles by supramolecular interactions with cyclodextrin hosts. Photochem Photobiol Sci; 2008 Aug;7(8):979-85
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  • Ground state absorption and steady-state and time-resolved fluorescence measurements have been carried out to understand the host-guest interactions of p-diethylaminobenzonitrile (DEABN) and p-dimethylaminobenzonitrile (DMABN) dyes with alpha-cyclodextrin (alpha-CD) and beta-cyclodextrin (beta-CD) hosts.
  • DEABN and DMABN dyes show both locally excited (LE) state and intramolecular charge transfer (ICT) state emissions in solution.
  • The LE and ICT emissions of the dyes are seen to get modulated in the presence of alpha-CD and beta-CD hosts.
  • The results indicate that the dyes form 1 : 1 inclusion complexes with both the hosts.
  • Comparing the binding constants and the fluorescence characteristics of different dye x CD systems it is inferred that DEABN adopts a completely different orientation on complexation with alpha-CD than in the other cases of dye.CD systems.
  • It is indicated that while in all other cases of dye x CD systems the N,N-dialkyl group of the dyes enters the host cavity leaving the C[triple bond, length as m-dash]N group projected out into the water phase, the DEABN dye enters the alpha-CD cavity (smallest CD) with its C[triple bond, length as m-dash]N group entering the host cavity.
  • The differences in the orientation of the dye in the host cavities is understood to be determined by the requirement of maximum van der Waals contact of the encapsulated dye with the host cavity for maximum stability of the complex and the relative sizes of the substituents of the dye compared to the host cavities.

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  • (PMID = 18688506.001).
  • [ISSN] 1474-905X
  • [Journal-full-title] Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • [ISO-abbreviation] Photochem. Photobiol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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45. Villaverde J, Maqueda C, Undabeytia T, Morillo E: Effect of various cyclodextrins on photodegradation of a hydrophobic herbicide in aqueous suspensions of different soil colloidal components. Chemosphere; 2007 Sep;69(4):575-84
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  • The irradiation of NFL aqueous solutions in the presence of CDs showed that the higher the formation constant of NFL-CD complexes (Kc) and their solubility, the higher their photocatalytic effects, following the CDs in the order: RAMEB>HPBCD>beta-CD>alpha-CD>gamma-CD.

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  • (PMID = 17462707.001).
  • [ISSN] 0045-6535
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Colloids; 0 / Cyclodextrins; 0 / Environmental Pollutants; 0 / Herbicides; 0 / Pyridazines; 0 / Soil; 0 / Solutions; KES1HB07E4 / norflurazone
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46. Stauffer BL, Konhilas JP, Luczak ED, Leinwand LA: Soy diet worsens heart disease in mice. J Clin Invest; 2006 Jan;116(1):209-16
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  • [Title] Soy diet worsens heart disease in mice.
  • We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy.
  • On a soy diet, males with a mutation in the alpha-myosin heavy chain gene progress to dilation and heart failure.
  • Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen synthase kinase 3beta (GSK3beta), and caspase-3 activation.

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  • (PMID = 16395406.001).
  • [ISSN] 0021-9738
  • [Journal-full-title] The Journal of clinical investigation
  • [ISO-abbreviation] J. Clin. Invest.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL067543-01; United States / NHLBI NIH HHS / HL / 1F32HL67543; United States / NIGMS NIH HHS / GM / T32 GM008759; United States / NHLBI NIH HHS / HL / F32 HL067543-01; United States / NHLBI NIH HHS / HL / F32 HL067543; United States / NHLBI NIH HHS / HL / 5F32HL070509; United States / NHLBI NIH HHS / HL / R01 HL050560; United States / NHLBI NIH HHS / HL / 2R01HL050560; United States / NHLBI NIH HHS / HL / F32 HL070509
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Soybean Proteins; EC 3.6.4.1 / Myosin Heavy Chains
  • [Other-IDs] NLM/ PMC1323247
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47. Landolsi A, Chabchoub I, Limem S, Gharbi O, Chaafai R, Hochlef M, Fatma LB, Trimech M, Krifa A, Ajmi S, Mokni M, Hadj Hmida MB, Ahmed SB: [Primary digestive tract lymphoma in central region of Tunisia: anatomoclinical study and therapeutic results about 153 cases]. Bull Cancer; 2010 Apr;97(4):435-43
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  • [Title] [Primary digestive tract lymphoma in central region of Tunisia: anatomoclinical study and therapeutic results about 153 cases].
  • [Transliterated title] Les lymphomes primitifs du tube digestif (LPTD) dans le centre tunisien: étude anatomoclinique et résultats thérapeutiques à propos de 153 cas.
  • Primary gastro-intestinal lymphoma (PGIL) is the most common type of extra-nodal non Hodgkin's lymphoma.
  • Their clinical and histological presentations are heterogeneous depending on the site of the lesion.
  • In our country epidemiology of the disease is unknown with IPSID being the most frequent type.
  • We report anatomo-clinical features and prognostic factors of PGIL and compare intestinal to gastric forms in our region.
  • Tumor sites were gastric (67%), intestinal (26%) and gastrointestinal (7%).
  • Abdominal pain (87%) followed by vomiting and diarrhoea (37 and 15%) were the most common symptoms.
  • Performance status (PS) < 2 was seen in 80% of patients, high grade lymphoma in 70.5% of cases and B phenotype was noted in 85%.
  • MALT lymphoma accounts for 50% of cases, and IPSID for only 5% of PGIL.
  • Only 46% of patients had surgery (14 for surgical complication, 6 for residual tumor after chemotherapy and 22 to have histological diagnosis).
  • In high grade lymphoma patients favorable prognostic factors for OS included young age < or = 60 years, PS < 2, normal serum LDH, hemoglobin > 12 g/dL, B phenotype, localised stage (IE-IIE1), anthracycline-based chemotherapy regimen, achieving complete or partial response to induction chemotherapy and no relapse.
  • In low-grade lymphoma patients, none of these factors had a significant correlation with OS: age < or = 60 years, PS < 2, stage (IE-IIE1), response to induction chemotherapy, relapse.
  • Compared to gastric lymphomas, intestinal cases occurred at a younger age, frequently with diarrhoea, weight loss, and occlusion.
  • We conclude that stomach is the main site of PGIL in our region, intestinal lymphoma is less frequent and IPSID has become rare.
  • [MeSH-major] Gastrointestinal Neoplasms. Lymphoma, Non-Hodgkin
  • [MeSH-minor] Abdominal Pain / etiology. Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diarrhea / etiology. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Tunisia. Vomiting / etiology. Young Adult

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  • (PMID = 20395189.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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48. Liu R, Zhang Y, Feng P: Multiresponsive supramolecular nanogated ensembles. J Am Chem Soc; 2009 Oct 28;131(42):15128-9
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  • The presence of UV light, alpha-CD, or disulfide reducing agent can effectively open the polymeric network and release the loading with different dynamics.

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  • (PMID = 19746981.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ: Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology; 2008 Feb;134(2):568-76
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  • [Title] Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease.
  • Liver histology was scored using the NASH clinical research network criteria.
  • Whereas immunoglobulin heavy chain binding protein mRNA was significantly increased in NASH, unspliced X-box protein-1 (XBP-1) protein did not increase.
  • Also, endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein mRNA levels were inversely related to spliced XBP-1 mRNA in NASH.

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  • (PMID = 18082745.001).
  • [ISSN] 1528-0012
  • [Journal-full-title] Gastroenterology
  • [ISO-abbreviation] Gastroenterology
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K24 DK 02755-07; United States / PHS HHS / / R01 56331; United States / NIDDK NIH HHS / DK / T32 DK 007150-32
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATF4 protein, human; 0 / ATF6 protein, human; 0 / Activating Transcription Factor 6; 0 / Antigens, Differentiation; 0 / Cell Cycle Proteins; 0 / DDIT3 protein, human; 0 / DNA-Binding Proteins; 0 / Eukaryotic Initiation Factor-2; 0 / Membrane Proteins; 0 / Transcription Factors; 0 / regulatory factor X transcription factors; 145891-90-3 / Activating Transcription Factor 4; 147336-12-7 / Transcription Factor CHOP; EC 2.7.1.- / ERN2 protein, human; EC 2.7.10.- / PERK kinase; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / eIF-2 Kinase; EC 2.7.12.2 / MAP Kinase Kinase 4; EC 3.1.- / Endoribonucleases; EC 3.1.3.16 / PPP1R15A protein, human; EC 3.1.3.16 / Protein Phosphatase 1
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50. Ilisz I, Fodor G, Iványi R, Szente L, Tóth G, Péter A: Enantioseparation of beta-methyl-substituted amino acids with cyclodextrins by capillary zone electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci; 2008 Nov 1;875(1):273-9
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  • Capillary zone electrophoresis was carried out using sulfopropylated-alpha-CD (SP2-alpha-CD), sulfopropylated-beta-CD (SP2-beta-CD) both with a degree of substitution of 2 moles/mole cyclodextrin, and sulfopropylated-beta-CD (SP4-beta-CD) with a degree of substitution of 4moles/mole beta-cyclodextrin.

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  • (PMID = 18514044.001).
  • [ISSN] 1570-0232
  • [Journal-full-title] Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • [ISO-abbreviation] J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Aminobutyrates; 0 / Cyclodextrins; 0 / beta-methyltryptophan; 2260-12-0 / 2-amino-3-phenylbutanoic acid; 42HK56048U / Tyrosine; 59-25-6 / beta-methyltyrosine; 8DUH1N11BX / Tryptophan
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51. Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F: Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma. J Allergy Clin Immunol; 2010 Aug;126(2):347-54
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  • [Title] Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.
  • In vitro studies have suggested that IL-4 receptor alpha (IL-4Ralpha) signaling on smooth muscle cells is critical for airway inflammation and airway hyperresponsiveness.
  • METHODS: By using transgenic smooth muscle myosin heavy chain(cre)IL-4Ralpha(-/lox) mice deficient in IL-4Ralpha in smooth muscle cells, in vivo effects of impaired IL-4Ralpha signaling in smooth muscle cells on the outcome of asthmatic disease were investigated for the first time.
  • Mice were investigated for the presence of airway hyperresponsiveness, airway inflammation, allergen-specific antibody production, T(h)2-type cytokine responses, and lung pathology.
  • RESULTS: Airway hyperresponsiveness, airway inflammation, mucus production, T(h)2 cytokine production, and specific antibody responses were unaffected in smooth muscle myosin heavy chain(cre)IL-4Ralpha(-/lox) mice compared with control animals.
  • These findings suggest that IL-4Ralpha responsiveness in airway smooth muscle cells during the early phase of allergic asthma is not, as suggested, necessary for the outcome of the disease.

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  • [Copyright] Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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  • (PMID = 20579713.001).
  • [ISSN] 1097-6825
  • [Journal-full-title] The Journal of allergy and clinical immunology
  • [ISO-abbreviation] J. Allergy Clin. Immunol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL085089-05; United States / NHLBI NIH HHS / HL / R01 HL085089; United States / NHLBI NIH HHS / HL / HL56835; United States / NHLBI NIH HHS / HL / R01 HL085089-05; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Allergens; 0 / Biomarkers; 0 / Il4ra protein, mouse; 0 / Interleukin-13; 0 / Receptors, Cell Surface; 207137-56-2 / Interleukin-4
  • [Other-IDs] NLM/ NIHMS204346; NLM/ PMC2917502
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52. North KN, Laing NG: Skeletal muscle alpha-actin diseases. Adv Exp Med Biol; 2008;642:15-27
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  • [Title] Skeletal muscle alpha-actin diseases.
  • Skeletal muscle alpha-actin is the principal protein component of the adult skeletal muscle thin filament.
  • The interaction between skeletal muscle alpha-actin and the various myosin heavy chain proteins in the different muscle fibre types generates the force of muscle contraction.
  • Skeletal muscle alpha-alpha actin is thus of fundamental importance to normal muscle contraction.
  • To date over 140 different disease-causing mutations have been identified in the skeletal muscle alpha-actin gene ACTA1.
  • These mutations are associated with histologically distinct congenital myopathies, including nemaline myopathy, actin myopathy, intranuclear rod myopathy, congenital fibre type disproportion and myopathy with cores.
  • Mutations in ACTA1 are associated with a wide range of clinical severity although the majority of patients tend to have severe congenital-onset disease.
  • Most of the patients have de novo dominant mutations not present in either parent.
  • However mild ACTA1 disease may be dominantly inherited and there are also recessive mutations.
  • Information from the clinic suggests that exercise and L-tyrosine may benefit some patients and that in the future decreasing the proportion of mutant actin may ameliorate the disease in some patients.
  • [MeSH-major] Actins / metabolism. Muscular Diseases / metabolism

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  • (PMID = 19181090.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins
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53. Gómara B, García-Ruiz C, Marina ML: Enantioselective separation of the sunscreen agent 3-(4-methylbenzylidene)-camphor by electrokinetic chromatography: Quantitative analysis in cosmetic formulations. Electrophoresis; 2005 Oct;26(20):3952-9
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  • Different experimental conditions (type and concentration of the chiral selector, temperature, and sample solvent) have been optimized.
  • The addition of increasing concentrations of the neutral alpha-CD to CM-beta-CD at a 15 mM concentration in a 100 mM borate buffer at pH 9.0 improved the enantiomeric separation and decreased peak tailing.

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  • (PMID = 16217832.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Cyclodextrins; 0 / Sunscreening Agents; 76-22-2 / Camphor; 8I3XWY40L9 / enzacamene
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54. Wirz W, Antoine M, Tag CG, Gressner AM, Korff T, Hellerbrand C, Kiefer P: Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells. Differentiation; 2008 Sep;76(7):784-94
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  • Hepatic stellate cells (HSCs) are pericytes of liver sinusoidal endothelial cells (LSECs) and activation of HSC into a myofibroblast-like phenotype (called transdifferentiation) is involved in several hepatic disease processes including neovascularization during liver metastasis, chronic and acute liver injury.
  • While early smooth muscle cell (SMC) differentiation markers including SM alpha-actin and SM22alpha are expressed in a variety of non-SMC, expression of late-stage markers is far more restricted.
  • Here, we found that in addition to early SMC markers, activated rat HSC express a large panel of characteristic late vascular SMC markers including SM myosin heavy chain, h1-calponin and h-caldesmon.

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  • (PMID = 18177423.001).
  • [ISSN] 1432-0436
  • [Journal-full-title] Differentiation; research in biological diversity
  • [ISO-abbreviation] Differentiation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Recombinant Proteins; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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55. Lipka E, Danel C, Orhan H, Bonte JP, Vaccher C: Chiral resolution of melatoninergic ligands by EKC using highly sulfated CDs. Electrophoresis; 2007 Nov;28(21):3915-21
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  • EKC methods for the enantiomeric resolutions of melatoninergic ligands were developed using anionic CDs (highly S-alpha-CD, highly S-beta-CD, and highly S-gamma-CD) as chiral selectors at acidic pH 2.5.

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  • (PMID = 17922520.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Buffers; 0 / Cyclodextrins; 0 / Indicators and Reagents; 0 / Ligands; 0 / Sulfuric Acid Esters; 0 / Tetrahydronaphthalenes; 0 / beta-Cyclodextrins; JL5DK93RCL / Melatonin
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56. Wan P, Jiang Y, Wang Y, Wang Z, Zhang X: Tuning surface wettability through photocontrolled reversible molecular shuttle. Chem Commun (Camb); 2008 Nov 30;(44):5710-2
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  • A photocontrolled molecular shuttle SAM based on an alpha-cyclodextrin (alpha-CD)/azobenzene inclusion complex on rough gold surfaces is fabricated, which can reversibly switch the surface wettability by transferring external energy (light) to molecular mechanical motion.

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  • (PMID = 19009056.001).
  • [ISSN] 1364-548X
  • [Journal-full-title] Chemical communications (Cambridge, England)
  • [ISO-abbreviation] Chem. Commun. (Camb.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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57. Danel C, Lipka E, Bonte JP, Goossens JF, Vaccher C, Foulon C: Enantioseparation of chiral N-imidazole derivatives by electrokinetic chromatography using highly sulfated cyclodextrins: mechanism of enantioselective recognition. Electrophoresis; 2005 Oct;26(20):3824-32
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  • Baseline separation of ten new substituted [1-(imidazo-1-yl)-1-phenylmethyl)] benzothiazolinone and benzoxazolinone derivatives, with one chiral center, was achieved by CD-EKC using highly sulfated CDs (alpha, beta, gamma highly S-CDs) as chiral selectors.
  • The influence of the type and concentration of the chiral selectors on the enantioseparations was investigated.
  • The enantiomers were resolved with analysis times inferior to 2.5 min and resolution factors R(s) of 3.73, 3.90, 1.40, and 4.35 for compounds 1, 2, 3, and 5, respectively, using 25 mM phosphate buffer at pH 2.5 containing either highly S-alpha-CD, highly S-beta-CD, and highly S-gamma-CD (3 or 4% w/v) at 298 K, with an applied field of 0.30 kV/cm.

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  • (PMID = 16217831.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Benzothiazoles; 0 / Benzoxazoles; 0 / Cyclodextrins; 0 / Imidazoles
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58. Park JW, Lee SY, Song HJ, Park KK: Self-inclusion behavior and circular dichroism of aliphatic chain-linked beta-cyclodextrin-viologen compounds and their reduced forms depending on the side of modification. J Org Chem; 2005 Nov 11;70(23):9505-13
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  • [Title] Self-inclusion behavior and circular dichroism of aliphatic chain-linked beta-cyclodextrin-viologen compounds and their reduced forms depending on the side of modification.
  • The self-inclusion behavior and induced circular dichroism (ICD) characteristics of two beta-cyclodextrin (beta-CD) derivatives, in which a 1-methyl-4,4'-bipyridinium (viologen) group is connected by an octamethylene chain to either the primary (2(2+)) or secondary (3(2+)) side of beta-CD, and of their reduced forms, are investigated.
  • 1H NMR studies showed that 2(2+) forms an intramolecular self-inclusion complex with K(in) = 3.1 +/- 0.4, whereas 3(2+) forms a head-to-head type of dimer with K(D) = 65 +/- 10 M(-1) at 25 degrees C. 2(2+) and 3(2+) form [2]pseudorotaxanes with alpha-CD, with the secondary side of the alpha-CD facing the viologen moiety.

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  • (PMID = 16268626.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Toyama Y, Pais E, Meiselman HJ, Alexy T: Effects of cyclodextrins on RBC aggregation and blood viscosity. Clin Hemorheol Microcirc; 2007;36(2):173-80
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  • Cyclic oligomers of glucose, termed cyclodextrins (CDs), can contain 6 (alpha-CD), 7 (beta-CD) or 8 (gamma-CD) glucose units and are able to remove cholesterol from platelet membranes and decrease platelet aggregation.
  • Our results indicate the expected dose-dependent inhibition of platelet aggregation by beta-CD, with no significant effects of alpha-CD or gamma-CD.
  • RBC aggregation studies showed no effect of alpha-CD but highly significant (p<0.01) decreases by both beta-CD and gamma-CD; at the concentrations studied (1.5 x 10(-3) to 1.5 mM), beta-CD had somewhat greater effects.
  • Blood viscosity was not affected by alpha-CD, but was significantly decreased in a dose-dependent manner by beta-CD and, at the highest concentration (1.5 mM), by gamma-CD.

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  • (PMID = 17325441.001).
  • [ISSN] 1386-0291
  • [Journal-full-title] Clinical hemorheology and microcirculation
  • [ISO-abbreviation] Clin. Hemorheol. Microcirc.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL15722; United States / NHLBI NIH HHS / HL / HL70595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Platelet Aggregation Inhibitors
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60. Suzaki Y, Taira T, Osakada K: Irreversible and reversible formation of a [2]rotaxane containing platinum(II) complex with an N-alkyl bipyridinium ligand as the axis component. Dalton Trans; 2006 Dec 7;(45):5345-51
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  • An N-Alkyl bipyridinium having a polymethylene chain and a bulky aryl group at the end, [4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2]Cl (Cl), reacts with K[PtCl3(dmso)] to produce the Pt complex with the N-alkyl bipyridinium ligand [Cl2(dmso)Pt{4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2}][PtCl3(dmso)] as a 6:1 mixture of trans and cis isomers ([trans-][PtCl3(dmso)] and [cis-][PtCl3(dmso)]).
  • Addition of alpha-cyclodextrin (alpha-CD) to a solution of Cl in dmso-d6/D2O (3:1) forms [2]pseudorotaxane [{4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2}.(alpha-CD)]Cl (Cl) which is equilibrated with Cl and alpha-CD in solution.
  • The reaction of K[PtCl3(dmso)] with Cl affords the [2]rotaxane [trans-Cl2(dmso)Pt{4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2}.(alpha-CD)][PtCl3(dmso)] ([trans-][PtCl3(dmso)]) which contains alpha-CD and [trans-][PtCl3(dmso)] as the cyclic and axis components, respectively.
  • Dissolution of a mixture of [trans-][PtCl3(dmso)], [cis-][PtCl3(dmso)] and alpha-CD in dmso-d6/D2O (3:1) forms a mixture of the rotaxanes containing [trans--d6][PtCl3(dmso)] and [cis--d6][PtCl3(dmso)].
  • The reaction involves partial dissociation of the bipyridinium from Pt of [trans-][PtCl3(dmso)] or [cis-][PtCl3(dmso)] to yield [PtCl3(dmso)] and formation of pseudorotaxane with alpha-CD, followed by recoordination of the bipyridinium to the Pt.

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  • (PMID = 17102859.001).
  • [ISSN] 1477-9226
  • [Journal-full-title] Dalton transactions (Cambridge, England : 2003)
  • [ISO-abbreviation] Dalton Trans
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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61. Wang F, Blanco E, Ai H, Boothman DA, Gao J: Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation. J Pharm Sci; 2006 Oct;95(10):2309-19
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  • For beta-lap and CD interactions, increasing complexation efficiency was observed in the order of alpha-CD, gamma-CD, and beta-CD. beta-Lap complexation with hydroxypropyl-beta-cyclodextrin (HPbeta-CD) prevented drug dissolution in PLGA, and led to fast release (79.6+/-2.1% after 2 days).
  • Sustained drug release was achieved when beta-lap was complexed with alpha-CD or gamma-CD.

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association
  • (PMID = 16883563.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA142543; United States / NCI NIH HHS / CA / R01 CA102792; United States / NCI NIH HHS / CA / CA90696
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclodextrins; 0 / Naphthoquinones; 0 / Polymers; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid; 4707-32-8 / beta-lapachone
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62. Liu YX, Zhang X, Wu F, Deng NS: [Influence of cyclodextrins on the photodegradation of bisphenol A induced by Fe(III)]. Huan Jing Ke Xue; 2008 Mar;29(3):638-42
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  • Cyclodextrins (CDs) can form a host/guest inclusion complex with bisphenol A(BPA).
  • In the presence of alpha- cyclodextrin or beta-cyclodextrin (alpha-CD or beta-CD), the photodegradation efficiency of BPA can be enhanced, but gamma-cyclodextrin (gamma-CD) showed inhibitive effect on the photodegradation efficiency.
  • The initial degradation rate of BPA firstly increased with increasing concentration of beta-CD and alpha-CD from 0 to 60 micromol L(-1), and the maximum rate was reached at the beta-CD concentration of 60 micromol L(-1), and then decreased.

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  • (PMID = 18649520.001).
  • [ISSN] 0250-3301
  • [Journal-full-title] Huan jing ke xue= Huanjing kexue
  • [ISO-abbreviation] Huan Jing Ke Xue
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Cyclodextrins; 0 / Estrogens, Non-Steroidal; 0 / Ferric Compounds; 0 / Phenols; 0 / Water Pollutants, Chemical; 3352-57-6 / Hydroxyl Radical; MLT3645I99 / bisphenol A
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63. Stroud JL, Paton GI, Semple KT: Linking chemical extraction to microbial degradation of 14C-hexadecane in soil. Environ Pollut; 2008 Nov;156(2):474-81
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  • However, the novel HP-alpha-CD shake extraction showed close correlation (r(2)=0.90, n=36, p<0.05) to the mineralisation data.

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  • (PMID = 18316143.001).
  • [ISSN] 1873-6424
  • [Journal-full-title] Environmental pollution (Barking, Essex : 1987)
  • [ISO-abbreviation] Environ. Pollut.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alkanes; 0 / Cyclodextrins; 0 / Soil; 0 / Soil Pollutants; F8Z00SHP6Q / n-hexadecane
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64. Dudekula S, Fragata M: Investigation of the electron transfer site of p-benzoquinone in isolated photosystem II particles and thylakoid membranes using alpha- and beta-cyclodextrins. J Photochem Photobiol B; 2006 Dec 1;85(3):177-83
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  • [Title] Investigation of the electron transfer site of p-benzoquinone in isolated photosystem II particles and thylakoid membranes using alpha- and beta-cyclodextrins.
  • The electron transfer sites of p-benzoquinone (pBQ) and 2,6-dichloro-p-benzoquinone (DCBQ) were investigated in thylakoid membranes and isolated photosystem II (PSII) particles from barley (Hordeum vulgare) using alpha- and beta-cyclodextrins (CD) at concentrations up to 16 mM.
  • The maxima percent OE enhancement at cyclodextrin concentrations above 14 mM are about 100% (alpha-CD) and 190% (beta-CD).
  • It was also found that in isolated PSII particles incubated with either pBQ or DCBQ the cyclodextrins induce only a small OE enhancement.
  • [MeSH-minor] Kinetics. alpha-Cyclodextrins / chemistry. beta-Cyclodextrins / chemistry

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  • (PMID = 16934484.001).
  • [ISSN] 1011-1344
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Benzoquinones; 0 / Photosystem II Protein Complex; 0 / alpha-Cyclodextrins; 0 / beta-Cyclodextrins; 3T006GV98U / benzoquinone; 697-91-6 / 2,6-dichlorobenzoquinone; S88TT14065 / Oxygen
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65. Zhou C, Fu X, Yan J, Fan Q, Li Z, Cianflone K, Wang D: Throat infection, neck and chest pain and cardiac response: a persistent infection-related clinical syndrome. J Huazhong Univ Sci Technolog Med Sci; 2009 Feb;29(1):19-24
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  • [Title] Throat infection, neck and chest pain and cardiac response: a persistent infection-related clinical syndrome.
  • Dizziness, chest discomfort, chest depression and dyspnea are a group of symptoms that are common complaints in clinical practice.
  • Patients with these symptoms are usually informed that while neurosis consequent to coronary heart disease is excluded nonetheless they remain unhealthy with no rational explanation or treatment.
  • Thirty-five patients received coronary artery angiography to exclude coronary heart disease.
  • Serum myocardial autoantibodies against beta(1)-adrenoceptor, alpha-myosin heavy chain, M(2)-muscarinic receptor and adenine-nucleotide translocator were tested, and inflammatory cytokines and high sensitivity C-reaction protein were measured and lymphocyte subclass was assayed by flow cytometry.
  • TNF-alpha, IL-1 and IL-6 were significantly higher in patients than in controls (P<0.01).
  • These data led to identification of a persistent respiratory infection-related clinical syndrome, including persistent throat infection, neck spinal lesion, rib cartilage inflammation, symptoms of cardiac depression and dyspnea with or without anxiety.
  • [MeSH-major] Chest Pain / diagnosis. Coronary Disease / diagnosis. Dyspnea / diagnosis. Neck Pain / diagnosis. Pharyngitis / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Dizziness / complications. Dizziness / diagnosis. Female. Humans. Male. Middle Aged. Prospective Studies. Syndrome. Virus Diseases / complications. Virus Diseases / diagnosis. Young Adult

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  • [Cites] J Clin Invest. 1993 May;91(5):1964-8 [7683693.001]
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  • (PMID = 19224156.001).
  • [ISSN] 1672-0733
  • [Journal-full-title] Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • [ISO-abbreviation] J. Huazhong Univ. Sci. Technol. Med. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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66. Bone S: Dielectric studies of water clusters in cyclodextrins: Relevance to the transition between slow and fast forms of thrombin. J Phys Chem B; 2006 Oct 19;110(41):20609-14
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  • In alpha-cyclodextrin hexahydrate (alpha-CD.6H2O), water molecules are ordered and occupy well-defined positions whereas in the larger beta-cyclodextrin dodecahydrate (beta-CD.12H2O), there is considerable disorder with water molecules freely arranged over several possible sites.
  • Here it is shown that beta-CD exhibits substantial structural flexibility and proton mobility compared with alpha-CD which is relatively very rigid and exhibits negligible short-range protonic conduction.

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  • (PMID = 17034250.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Enzymes; 0 / Protons; 059QF0KO0R / Water; EC 3.4.21.5 / Thrombin
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67. Osaki M, Takashima Y, Yamaguchi H, Harada A: An artificial molecular chaperone: poly-pseudo-rotaxane with an extensible axle. J Am Chem Soc; 2007 Nov 21;129(46):14452-7
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  • Poly-pseudo-rotaxanes CDs contains as a subset 1 (CDs; cyclodextrins, 1; poly(delta-valerolactone) having single beta-CD at the end of the polymer chain) initiate polymerization of delta-valerolactone (delta-VL) in the solid state when CDs (alpha-CD, beta-CD, and 2,6-di-O-methyl-beta-CD) are threaded onto the polymer chain.
  • The polymer chain of beta-CD contains as a subset 1 was found to elongate in the solid state, whereas the polymer chain of 1 formed a random coil conformation.
  • 1 was deactivated for the polymerization by blocking the active cavity of beta-CD with the polymer chain.
  • CDs threaded onto 1 are immune to the initiation of delta-VL directly but have an essential role to fold the polymer chain in a proper way as an artificial chaperone.

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  • (PMID = 17973382.001).
  • [ISSN] 0002-7863
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Lactones; 0 / Molecular Chaperones; 0 / Polymers; 0 / Rotaxanes
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68. Jung JH, Lee SJ, Kim JS, Lee WS, Sakata Y, Kaneda T: alpha-CD/crown-appended diazophenol for selective sensing of amines. Org Lett; 2006 Jul 6;8(14):3009-12
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  • [Title] alpha-CD/crown-appended diazophenol for selective sensing of amines.

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  • (PMID = 16805539.001).
  • [ISSN] 1523-7060
  • [Journal-full-title] Organic letters
  • [ISO-abbreviation] Org. Lett.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / S06 GM 08194
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amines; 0 / Azo Compounds; 0 / Coloring Agents; 0 / Phenols
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69. Mofaddel N, Krajian H, Villemin D, Desbène PL: Enantioseparation of binaphthol and its mono derivatives by cyclodextrin-modified capillary zone electrophoresis. J Chromatogr A; 2008 Nov 21;1211(1-2):142-50
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  • With these known physicochemical characteristics, we could successfully carry out enantiomeric separations of the different binaphthols at pH 11.5, practically in completely ionized form, in phosphate medium, and in the presence of cyclodextrin (CD), with analysis times lower than 8min.
  • The nature of CDs (alpha-CD, beta-CD, gamma-CD, hydroxypropyl-alpha-cyclodextrin (HP-alpha-CD), HP-beta-CD, HP-gamma-CD and trimethyl-beta-CD (TM-beta-CD)) and other factors in relation to enantiomeric resolution (applied voltage, nature and concentration of the electrolyte, and concentration of cyclodextrin) were optimized.

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  • (PMID = 18930236.001).
  • [ISSN] 0021-9673
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Naphthols
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70. Joudieh S, Bon P, Martel B, Skiba M, Lahiani-Skiba M: Cyclodextrin polymers as efficient solubilizers of albendazole: complexation and physico-chemical characterization. J Nanosci Nanotechnol; 2009 Jan;9(1):132-40
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  • The apparent solubility of Albendazole was enhanced especially with poly alpha-CD.
  • The formation of inclusion complexes with natural CDs and polymers of cyclodextrin in the solid-state form were confirmed by Fourier Fransform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR).

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  • (PMID = 19441287.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Girolami F, Ho CY, Semsarian C, Baldi M, Will ML, Baldini K, Torricelli F, Yeates L, Cecchi F, Ackerman MJ, Olivotto I: Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. J Am Coll Cardiol; 2010 Apr 6;55(14):1444-53
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  • [Title] Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations.
  • OBJECTIVES: The aim of this study was to describe the clinical profile associated with triple sarcomere gene mutations in a large hypertrophic cardiomyopathy (HCM) cohort.
  • BACKGROUND: In patients with HCM, double or compound sarcomere gene mutation heterozygosity might be associated with earlier disease onset and more severe outcome.
  • METHODS: A total of 488 unrelated index HCM patients underwent screening for myofilament gene mutations by direct deoxyribonucleic acid sequencing of 8 genes, including myosin binding protein C (MYBPC3), beta-myosin heavy chain (MYH7), regulatory and essential light chains (MYL2, MYL3), troponin-T (TNNT2), troponin-I (TNNI3), alpha-tropomyosin (TPM1), and actin (ACTC).
  • The fourth patient, however, had clinically mild disease.

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  • [Copyright] Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] J Am Coll Cardiol. 2010 Apr 6;55(14):1454-5 [20359595.001]
  • (PMID = 20359594.001).
  • [ISSN] 1558-3597
  • [Journal-full-title] Journal of the American College of Cardiology
  • [ISO-abbreviation] J. Am. Coll. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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72. Yang C, Li J: Thermoresponsive behavior of cationic polyrotaxane composed of multiple pentaethylenehexamine-grafted alpha-cyclodextrins threaded on poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymer. J Phys Chem B; 2009 Jan 22;113(3):682-90
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  • [Title] Thermoresponsive behavior of cationic polyrotaxane composed of multiple pentaethylenehexamine-grafted alpha-cyclodextrins threaded on poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymer.
  • This paper reports the synthesis and the studies of the thermoresponsive behavior of a new cationic polyrotaxane consisting of multiple pentaethylenehexamine-grafted alpha-cyclodextrin (PEHA-grafted-alpha-CD) rings threaded on a poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO-PPO) triblock copolymer.
  • The PEHA-grafted alpha-CD rings were threaded and embedded in the PEO block of the block copolymer, forming a hydrophilic polyrotaxane domain, while the two PPO blocks flank the cationic polyrotaxane domain.
  • The cationic polyrotaxane was found to form thermosensitive micelles in aqueous solution.

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  • (PMID = 19143572.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chelating Agents; 0 / Cyclodextrins; 0 / Micelles; 0 / PEO-PPO-PEO; 0 / Polyamines; 0 / Propylene Glycols; 0 / Rotaxanes; 0 / polyrotaxane; 106392-12-5 / Poloxamer; 30IQX730WE / Polyethylene Glycols; 4067-16-7 / pentaethylenehexamine
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73. Fourmentin S, Outirite M, Blach P, Landy D, Ponchel A, Monflier E, Surpateanu G: Solubilisation of chlorinated solvents by cyclodextrin derivatives: a study by static headspace gas chromatography and molecular modelling. J Hazard Mater; 2007 Mar 6;141(1):92-7
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  • The capacity of alpha-cyclodextrin (alpha-CD) and four beta-cyclodextrins (beta-CDs) in reducing the volatility of volatile organic compounds (VOCs) and particularly carbon tetrachloride (CT), chloroform (TCM) and dichloromethane (DCM) is investigated by using static headspace gas chromatography (HSGC).

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  • (PMID = 16901631.001).
  • [ISSN] 0304-3894
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Hydrocarbons, Chlorinated
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74. Huang RJ, Hou X, Hoffmann T: Extensive evaluation of a diffusion denuder technique for the quantification of atmospheric stable and radioactive molecular iodine. Environ Sci Technol; 2010 Jul 1;44(13):5061-6
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  • In this paper we present the evaluation and optimization of a new approach for the quantification of gaseous molecular iodine (I(2)) for laboratory- and field-based studies and its novel application for the measurement of radioactive molecular iodine. alpha-Cyclodextrin (alpha-CD) in combination with (129)I(-) is shown to be an effective denuder coating for the sampling of gaseous I(2) by the formation of an inclusion complex.
  • A set of parameters affecting the analytical performances of this approach, including amount of alpha-CD and (129)I(-) applied, denuder length, sampling gas flow rate and sampling duration, relative humidity, sample storage period, and condition of release and derivatization of iodine, is extensively evaluated and optimized.
  • [MeSH-minor] Air Pollutants. Air Pollutants, Radioactive. Atmosphere. Diffusion. Environmental Monitoring / methods. Gas Chromatography-Mass Spectrometry / methods. Gases. Germany. Ireland. Reproducibility of Results. Time Factors. alpha-Cyclodextrins / chemistry

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  • (PMID = 20524649.001).
  • [ISSN] 0013-936X
  • [Journal-full-title] Environmental science & technology
  • [ISO-abbreviation] Environ. Sci. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Air Pollutants, Radioactive; 0 / Gases; 0 / Iodine Radioisotopes; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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75. Yap KL, Liu X, Thenmozhiyal JC, Ho PC: Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis. Eur J Pharm Sci; 2005 May;25(1):49-56
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  • This study investigated the effects of the complexation of 13-cis-RA with alpha-cyclodextrin (alpha-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on its phase solubility.
  • HP-beta-CD was found to be more effective in increasing the aqueous solubility of 13-cis-RA compared to alpha-CD.
  • [MeSH-major] Isotretinoin / administration & dosage. Isotretinoin / chemistry. alpha-Cyclodextrins / administration & dosage. beta-Cyclodextrins / administration & dosage

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  • (PMID = 15854800.001).
  • [ISSN] 0928-0987
  • [Journal-full-title] European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • [ISO-abbreviation] Eur J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / alpha-Cyclodextrins; 0 / beta-Cyclodextrins; EH28UP18IF / Isotretinoin; JV039JZZ3A / betadex; Z1LH97KTRM / alpha-cyclodextrin
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76. Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ: Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation; 2009 Mar 17;119(10):1398-407
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  • BACKGROUND: Cardiac hypertrophy, the clinical hallmark of hypertrophic cardiomyopathy (HCM), is a major determinant of morbidity and mortality not only in HCM but also in a number of cardiovascular diseases.
  • METHODS AND RESULTS: We treated 2-year-old beta-myosin heavy-chain Q403 transgenic rabbits with established cardiac hypertrophy and preserved systolic function with N-acetylcysteine or a placebo for 12 months (n=10 per group).
  • Transgenic rabbits in the placebo group had cardiac hypertrophy, fibrosis, systolic dysfunction, increased oxidized to total glutathione ratio, higher levels of activated thiol-sensitive active protein kinase G, dephosphorylated nuclear factor of activated T cells (NFATc1) and phospho-p38, and reduced levels of glutathiolated cardiac alpha-actin.
  • Treatment with N-acetylcysteine restored oxidized to total glutathione ratio, normalized levels of glutathiolated cardiac alpha-actin, reversed cardiac and myocyte hypertrophy and interstitial fibrosis, reduced the propensity for ventricular arrhythmias, prevented cardiac dysfunction, restored myocardial levels of active protein kinase G, and dephosphorylated NFATc1 and phospho-p38.
  • Because there is no effective pharmacological therapy for HCM and given that hypertrophy, fibrosis, and cardiac dysfunction are common and major predictors of clinical outcomes, the findings could have implications in various cardiovascular disorders.

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  • (PMID = 19255346.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] ENG
  • [Grant] None / None / / R01 HL068884-04; None / None / / P50 HL054313-090012; United States / NHLBI NIH HHS / HL / P50 HL054313; United States / NHLBI NIH HHS / HL / R01 HL068884-02; None / None / / P50 HL054313-060012; United States / NHLBI NIH HHS / HL / R01 HL068884-04; United States / NIAMS NIH HHS / AR / R01 AR056223; United States / NHLBI NIH HHS / HL / R01 HL068884-01; United States / NHLBI NIH HHS / HL / P50 HL054313-080012; None / None / / R01 HL068884-03; United States / NHLBI NIH HHS / HL / R01-HL68884; United States / NHLBI NIH HHS / HL / R01 HL068884-03; United States / NHLBI NIH HHS / HL / R01 HL068884; United States / NHLBI NIH HHS / HL / P50 HL054313-070012; None / None / / P50 HL054313-100012; None / None / / P50 HL054313-08S10012; None / None / / P50 HL054313-080012; United States / NHLBI NIH HHS / HL / P50 HL054313-08S10012; United States / NHLBI NIH HHS / HL / R01 HL068884-05; United States / NHLBI NIH HHS / HL / P50 HL054313-090012; None / None / / R01 HL068884-05; None / None / / P50 HL054313-070012; None / None / / R01 HL068884-02; United States / NHLBI NIH HHS / HL / R01-HL67322; United States / NHLBI NIH HHS / HL / P50 HL054313-100012; United States / NHLBI NIH HHS / HL / R01 HL067322; United States / NHLBI NIH HHS / HL / P50 HL054313-060012; None / None / / R01 HL068884-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antioxidants; 0 / NFATC Transcription Factors; 0 / Sulfhydryl Compounds; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.6.4.1 / Myosin Heavy Chains; GAN16C9B8O / Glutathione; WYQ7N0BPYC / Acetylcysteine
  • [Other-IDs] NLM/ NIHMS113912; NLM/ PMC2773801
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77. Mehta SK, Bhasin KK, Dham S, Singla ML: Micellar behavior of aqueous solutions of dodecyldimethylethylammonium bromide, dodecyltrimethylammonium chloride and tetradecyltrimethylammonium chloride in the presence of alpha-, beta-, HPbeta- and gamma-cyclodextrins. J Colloid Interface Sci; 2008 May 15;321(2):442-51
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  • [Title] Micellar behavior of aqueous solutions of dodecyldimethylethylammonium bromide, dodecyltrimethylammonium chloride and tetradecyltrimethylammonium chloride in the presence of alpha-, beta-, HPbeta- and gamma-cyclodextrins.
  • Conductivity, static fluorescence and (1)H NMR measurements have been carried out to study the micellar behavior of aqueous solutions of dodecyldimethylethylammonium bromide (DDAB), dodecyltrimethylammonium chloride (DTAC) and tetradecyltrimethylammonium chloride (TDAC) in absence and presence of alpha-cyclodextrin (alpha-CD), beta-cyclodextrin (beta-CD), hydroxypropyl-beta-cyclodextrin (HPbeta-CD) and gamma-cyclodextrin (gamma-CD).

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  • (PMID = 18342875.001).
  • [ISSN] 0021-9797
  • [Journal-full-title] Journal of colloid and interface science
  • [ISO-abbreviation] J Colloid Interface Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Zhang P, Polavarapu PL: Spectroscopic investigation of the structures of dialkyl tartrates and their cyclodextrin complexes. J Phys Chem A; 2007 Feb 8;111(5):858-71
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  • Binding constants of alpha-CD and beta-CD with diethyl L-tartrate in both H2O and DMSO have been determined using isothermal titration calorimetry technique.

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  • (PMID = 17266226.001).
  • [ISSN] 1089-5639
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Tartrates; 059QF0KO0R / Water; CL2T97X0V0 / Carbon Tetrachloride; YOW8V9698H / Dimethyl Sulfoxide
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79. Murdaca G, Contini P, Setti M, Cagnati P, Villa R, Lantieri F, Indiveri F, Puppo F: Behavior of serum human major histocompatibility complex class I antigen levels in human immunodeficiency virus-infected patients during antiretroviral therapy: correlation with clinical outcome. Hum Immunol; 2007 Nov;68(11):894-900
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  • [Title] Behavior of serum human major histocompatibility complex class I antigen levels in human immunodeficiency virus-infected patients during antiretroviral therapy: correlation with clinical outcome.
  • Human major histocompatibility complex class I antigens (HLA-A, -B, and -C) are heterodimeric molecules composed of a alpha heavy chain noncovalently associated with an invariant protein known as beta(2)-microglobulin.
  • The introduction of highly active antiretroviral therapy (HAART) modified the clinical course of the disease and decreased the acquired immunodeficiency syndrome-related morbidity and mortality.
  • [MeSH-minor] Adult. CD4 Lymphocyte Count. Female. HIV / isolation & purification. Humans. Male. Middle Aged. RNA, Viral / blood. Receptors, Tumor Necrosis Factor, Type II / blood. Treatment Outcome. Viral Load. beta 2-Microglobulin / blood


80. Chunmao L, Junze M, Yong Z: Study on effects of cyclodextrins on the photolysis of dissolved anthracene by fluorometry. Luminescence; 2005 Jul-Oct;20(4-5):261-5
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  • The order of the promotion effect for the five kinds of CDs was as follows: HPCD(hydroxypropyl-beta-CD) > DMCD(heptakis(2,6-di-O-methyl)-beta-CD > beta-CD > gamma-CD > alpha-CD.

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  • [Copyright] Copyright 2005 John Wiley & Sons, Ltd.
  • (PMID = 16134226.001).
  • [ISSN] 1522-7235
  • [Journal-full-title] Luminescence : the journal of biological and chemical luminescence
  • [ISO-abbreviation] Luminescence
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthracenes; 0 / Cyclodextrins; 0 / Solutions; EH46A1TLD7 / anthracene
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81. George TI, Wrede JE, Bangs CD, Cherry AM, Warnke RA, Arber DA: Low-grade B-Cell lymphomas with plasmacytic differentiation lack PAX5 gene rearrangements. J Mol Diagn; 2005 Aug;7(3):346-51
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  • [Title] Low-grade B-Cell lymphomas with plasmacytic differentiation lack PAX5 gene rearrangements.
  • The chromosomal translocation t(9;14)(p13;q32) has been reported in association with lymphoplasmacytic lymphoma (LPL).
  • Although this translocation involving the paired homeobox-5 (PAX5) gene at chromosome band 9p13 and the immunoglobulin heavy chain (IgH) gene at 14q32 has been described in approximately 50% of LPL cases, the actual number of cases studied is quite small.
  • Many of the initial cases associated with t(9;14)(p13;q32) were actually low-grade B-cell lymphomas with plasmacytic differentiation other than LPL.
  • Thus, we analyzed a series of low-grade B-cell lymphomas for PAX5 gene rearrangements.
  • We searched records from the Department of Pathology, Stanford University Medical Center for low-grade B-cell lymphomas, with an emphasis on plasmacytic differentiation, that had available paraffin blocks or frozen tissue.
  • We identified 37 cases, including 13 LPL, 18 marginal zone lymphomas (nodal, extranodal, splenic, and alpha-heavy chain disease), and 6 small lymphocytic lymphomas.
  • All cases failed to demonstrate a PAX5 translocation, indicating that t(9;14)(p13;q32) and other PAX5 translocations are uncommon events in low-grade B-cell lymphomas with plasmacytic differentiation.

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  • (PMID = 16049306.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA034233; United States / NCI NIH HHS / CA / CA34233
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / B-Cell-Specific Activator Protein; 0 / DNA Probes; 0 / DNA-Binding Proteins; 0 / PAX5 protein, human; 0 / Transcription Factors
  • [Other-IDs] NLM/ PMC1867539
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82. Nagaraju M, Sastry GN: Theoretical studies on inclusion complexes of cyclodextrins. J Phys Chem A; 2009 Aug 27;113(34):9533-42
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  • Quantum chemical calculations and molecular dynamics simulations are carried out to study the host-guest inclusion complexes of cyclodextrins (alpha-, beta-, and gamma-CDs) with small guest molecules such as H(2)O, NH(3), NH(4)(+), C(6)H(6), and bisimidazolyl compounds.
  • The uptake ability of the CDs to accommodate the small molecules inside the cavity is examined by the sequential addition of 10 molecules of water or ammonia using the semiempirical (PM3) method.
  • PM3 calculations indicate that alpha-, beta-, and gamma-CD can accommodate three, seven, and nine water molecules, respectively.
  • In the case of NH(3) as guest molecule, alpha-, beta-, and gamma-CDs can accommodate up to two, five, and six molecules, respectively.
  • Semiempirical calculations indicate that two benzene molecules can be accommodated in the alpha-CD cavity, whereas beta- and gamma-CD cavities adopt three and four benzene molecules, respectively.
  • The interaction energies calculated by the MM/PBSA method reveal that ligand 1,6-bis(imidazol-l-lyl) hexane (B) and 1,4-bis(imidazol-l-lylmethyl) benzene (C) molecules prefer to form 1:1 complexes with alpha-, beta-, and gamma-CDs.
  • However, C preferentially forms 1:2 complexes with alpha-CDs.
  • Ligands 1,10-bis(imidazol-l-lyl) decane (A) and 4,4'-(bis(imidazol-l-ylmethylene))biphenyl (D) form 1:2 complexes with alpha-, beta-, and gamma-CDs in head-to-head (HH) orientation of CDs.
  • The stability of inclusion compounds depends on the type of CD and the physicochemical properties of the involved guest.
  • Both of these methods (semiempirical and MD simulations) reveal that beta-CDs form more stable complexes compared with alpha- and gamma-CDs with C, D, NH(4)(+), and C(6)H(6), whereas alpha-CD forms more stable complexes with A and B.

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  • (PMID = 19655710.001).
  • [ISSN] 1520-5215
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins
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83. Pidkovka NA, Cherepanova OA, Yoshida T, Alexander MR, Deaton RA, Thomas JA, Leitinger N, Owens GK: Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro. Circ Res; 2007 Oct 12;101(8):792-801
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  • Atherosclerosis is a vascular disease characterized by lipid deposition and inflammation within the arterial wall.
  • Phenotypic switching of smooth muscle cells (SMCs) plays a critical role in the development, progression, and end-stage clinical consequences of atherosclerosis, yet little is known regarding the effects of specific oxPLs on SMC phenotype.
  • Results showed that POVPC and PGPC induced profound suppression of smooth muscle (SM) alpha-actin and SM myosin heavy chain expression while simultaneously increasing expression of MCP-1, MCP-3, and cytolysin.

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  • [CommentIn] Circ Res. 2007 Oct 12;101(8):750-1 [17932331.001]
  • (PMID = 17704209.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / P01HL19242; United States / NHLBI NIH HHS / HL / R01HL084422-01; United States / NHLBI NIH HHS / HL / R01HL38854; United States / NHLBI NIH HHS / HL / R37HL57353
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GKLF protein; 0 / Kruppel-Like Transcription Factors; 0 / Phospholipids
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84. Schipper BR, Ramstad T: Determination of the binding constant between alprostadil and alpha-cyclodextrin by capillary electrophoresis: implications for a freeze-dried formulation. J Pharm Sci; 2005 Jul;94(7):1528-37
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  • [Title] Determination of the binding constant between alprostadil and alpha-cyclodextrin by capillary electrophoresis: implications for a freeze-dried formulation.
  • The binding constant between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD) was determined at three temperatures by capillary electrophoresis. alpha-CD is an excipient material in Caverject Dual Chamber Syringe (DCS), added to enhance stability.
  • The concentration of PGE1 was fixed while the concentration of alpha-CD was varied over a suitable range.
  • As the amount of PGE1 bound to alpha-CD increases, the weighted average of the resultant mobility decreases, thereby allowing a binding isotherm to be generated from which the stability constant was extracted via nonlinear regression analysis.
  • Po., an earlier-developed product that contains no alpha-CD.
  • [MeSH-major] Alprostadil / chemistry. Electrophoresis, Capillary. Freeze Drying. Platelet Aggregation Inhibitors / chemistry. alpha-Cyclodextrins / chemistry

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15920771.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Buffers; 0 / Platelet Aggregation Inhibitors; 0 / alpha-Cyclodextrins; F5TD010360 / Alprostadil; Z1LH97KTRM / alpha-cyclodextrin
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85. Zhang Q, Tu Y, Tian H, Zhao YL, Stoddart JF, Agren H: Working mechanism for a redox switchable molecular machine based on cyclodextrin: a free energy profile approach. J Phys Chem B; 2010 May 20;114(19):6561-6
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  • This paper reports the working mechanism for a redox-responsive bistable [2]rotaxane incorporating an alpha-cyclodextrin (alpha-CD) ring (J. Am. Chem. Soc.
  • Employing an umbrella sampling technique, the free energy profiles (potential of mean force, PMF) were calculated for the shuttling motion of the alpha-CD ring between a tetrathiafulvalene (TTF) recognition site and a triazole (TZ) unit on the dumbbell of the rotaxane for three oxidation states (0, +1, +2) of the TTF unit.
  • Analysis of the free energy components reveals that, for these alpha-CD-based rotaxanes with charged TTF units, the real driving force for the shuttling in the oxidized states is actually the interactions between water and the rotaxane components, which overwhelms the attractive interactions between the alpha-CD ring and the charged dumbbell.

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  • (PMID = 20394400.001).
  • [ISSN] 1520-5207
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Ziblat R, Lirtsman V, Davidov D, Aroeti B: Infrared surface plasmon resonance: a novel tool for real time sensing of variations in living cells. Biophys J; 2006 Apr 1;90(7):2592-9
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  • Upon application of the inactive analog alpha-cyclodextrin (alpha-CD), the effects were minimal.
  • [MeSH-minor] Biosensing Techniques. Cells, Cultured. Cholesterol / chemistry. Cholesterol / metabolism. Circular Dichroism. Cyclodextrins / chemistry. Electrochemistry / methods. HeLa Cells. Humans. Lipids / chemistry. Microscopy, Electron. Phosphatidylcholines / chemistry. Phospholipids / chemistry. Refractometry. Time Factors. alpha-Cyclodextrins / chemistry

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  • (PMID = 16399831.001).
  • [ISSN] 0006-3495
  • [Journal-full-title] Biophysical journal
  • [ISO-abbreviation] Biophys. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Lipids; 0 / Phosphatidylcholines; 0 / Phospholipids; 0 / alpha-Cyclodextrins; 97C5T2UQ7J / Cholesterol; TE895536Y5 / 1-palmitoyl-2-oleoylphosphatidylcholine; Z1LH97KTRM / alpha-cyclodextrin
  • [Other-IDs] NLM/ PMC1403176
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87. Jiménez V, Alderete JB: Hartree-Fock and density functional theory study of alpha-cyclodextrin conformers. J Phys Chem A; 2008 Jan 31;112(4):678-85
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  • [Title] Hartree-Fock and density functional theory study of alpha-cyclodextrin conformers.
  • Herein, we report the geometry optimization of four conformers of alpha-cyclodextrin (alpha-CD) by means of PM3, HF/STO-3G, HF/3-21G, HF/6-31G(d), B3LYP/6-31G(d), and X3LYP/6-31G(d) calculations.
  • The analysis of several geometrical parameters indicates that all conformers possess bond lengths, angles, and dihedrals that agree fairly well with the crystalline structure of alpha-CD.
  • Among them, conformer 3 appears to be the most stable species both in the gas phase and in solution; therefore, it is expected to be the most suitable representative structure for alpha-CD conformation.
  • Our results indicate that the choice of a particular alpha-CD conformer should affect the results of ab initio computational studies on the inclusion complexation with this cyclodextrin since both the direction and the magnitude of the dipole moment depend strongly on the conformation of alpha-CD.
  • [MeSH-major] Computer Simulation. Models, Chemical. alpha-Cyclodextrins / chemistry

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  • (PMID = 18177023.001).
  • [ISSN] 1089-5639
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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88. Plazanet M, Bartolini P, Sangregorio C, Taschin A, Torre R, Trommsdorff HP: Inverse freezing in molecular binary mixtures of alpha-cyclodextrin and 4-methylpyridine. Phys Chem Chem Phys; 2010 Jul 14;12(26):7026-31
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  • [Title] Inverse freezing in molecular binary mixtures of alpha-cyclodextrin and 4-methylpyridine.
  • Ternary solutions of alpha-cyclodextrin (alphaCD) in 4-methylpyridine (4MP)/water mixtures solidify when heated and melt when cooled, and the crystalline solid phase exhibits a rich phase behavior as a function of temperature.
  • In this work, we extend these earlier investigations to pure binary mixtures of alphaCD in water free 4MP, characterized via temperature and time dependent measurements of viscosity, X-ray diffraction, and infrared spectroscopy, complemented by observations of acoustic properties and small angle neutron diffraction.

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  • (PMID = 20464011.001).
  • [ISSN] 1463-9084
  • [Journal-full-title] Physical chemistry chemical physics : PCCP
  • [ISO-abbreviation] Phys Chem Chem Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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89. Urbánek M, Varenne A, Gebauer P, Krivánková L, Gareil P: Determination of trace cationic impurities in butylmethylimidazolium-based ionic liquids: from transient to comprehensive single-capillary counterflow isotachophoresis-zone electrophoresis. Electrophoresis; 2006 Dec;27(23):4859-71
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  • To induce ITP, three different strategies were evaluated: (i) Sample self-stacking ensured by the addition of ammonium acetate (NH(4)Ac) to 25-50-fold diluted IL solution (transient ITP). (ii) Complete ITP-ZE separation performed in a single capillary: ITP was realized in discontinuous electrolytes comprising an 80 mM NH(4)Ac, 40 mM acetic acid, 30 mM alpha-CD, pH 5.05, leading electrolyte (LE) and a 10 mM creatinine, 10 mM acetic acid, pH 4.9, terminating electrolyte (TE).
  • This protocol made it possible to accommodate a 2.5-times diluted IL sample. (iii) Complete counterflow ITP-ZE with continuous electrokinetic sample supply: the ITP stage was performed in a capillary filled with a 150 mM NH(4)Ac, 75 mM acetic acid, 30 mM alpha-CD, pH 5.0 LE, with 40-times diluted IL at the capillary inlet.

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  • (PMID = 17136724.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide; 0 / Buffers; 0 / Cations; 0 / Imidazoles; 0 / Imides; 0 / Ionic Liquids; 9FN79X2M3F / Lithium; 9NEZ333N27 / Sodium
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90. Vaiphei K, Kumari N, Sinha SK, Dutta U, Nagi B, Joshi K, Singh K: Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease. World J Gastroenterol; 2006 Jun 14;12(22):3602-8
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  • [Title] Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease.
  • AIM: To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease (IPSID) and to study profiles of kappa (kappa) and lambda (lambda) light chains and IgA heavy chain.
  • METHODS: The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum.
  • The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry.
  • RESULTS: All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration.
  • According to Galian's histological staging, there were 4 patients with stage A and 7 with stage B. kappa and lambda light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission.
  • Syndecan-1, kappa and lambda light chains and IgA heavy chain showed inverse relationship with bcl6 and p53.
  • CHOP regime was added in 5 patients who developed frank lymphoma.
  • Three died of the disease due to extensive organ infiltration.
  • CONCLUSION: Certain immunomarkers like syndecan-1, kappa and lambda light chains and IgA heavy chain could be of much help in identifying early stage IPSID.
  • Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.
  • [MeSH-major] DNA-Binding Proteins / genetics. Immunoproliferative Small Intestinal Disease / diagnosis. Immunoproliferative Small Intestinal Disease / genetics. Membrane Glycoproteins / genetics. Proteoglycans / genetics. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Case-Control Studies. Disease Progression. Doxycycline / therapeutic use. Endoscopy, Gastrointestinal. Female. Gene Expression Regulation. Helicobacter pylori. Humans. Immunoglobulin alpha-Chains / blood. Immunoglobulin alpha-Chains / genetics. Immunoglobulin kappa-Chains / analysis. Immunoglobulin kappa-Chains / genetics. Immunoglobulin lambda-Chains / analysis. Immunoglobulin lambda-Chains / genetics. Immunohistochemistry. Intestinal Mucosa / chemistry. Intestinal Mucosa / microbiology. Intestinal Mucosa / pathology. Intestine, Small / chemistry. Intestine, Small / microbiology. Intestine, Small / pathology. Male. Middle Aged. Prognosis. Syndecan-1. Syndecans

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  • (PMID = 16773719.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / BCL6 protein, human; 0 / DNA-Binding Proteins; 0 / Immunoglobulin alpha-Chains; 0 / Immunoglobulin kappa-Chains; 0 / Immunoglobulin lambda-Chains; 0 / Membrane Glycoproteins; 0 / Proteoglycans; 0 / SDC1 protein, human; 0 / Syndecan-1; 0 / Syndecans; 0 / Tumor Suppressor Protein p53; N12000U13O / Doxycycline
  • [Other-IDs] NLM/ PMC4087578
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91. Koyama J, Morita I, Kobayashi N: Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis. J Chromatogr A; 2007 Mar 23;1145(1-2):183-9
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  • A UV-diode array detector (DAD) at 254 nm with a gradient elution of acetonitrile/water (method A: 0 min 6:94, 12 min 12:88, 15 min 20:80, 40 min 25:75, 53 min 55:45, 55 min 100:0; method B: 0 min 5:95, 2 min 15:85, 5 min 20:80, 12 min 25:75, 15 min 50:50, 19 min 98:2) at 28(+/-1) degrees C (method A) and 30-60 degrees C (method B) in HPLC or with 0.03 M borate buffer (pH 10.0) containing 25% (v/v) acetonitrile with 0.002 M 2,6-di-O-methyl-beta-cyclodextrin (CD) and 0.005 M alpha-CD in CE effectively detected this separation in 25 min.

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  • (PMID = 17289060.001).
  • [ISSN] 0021-9673
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anthraquinones; 0 / Glucosides; 517-43-1 / sennoside A&B; 8013-11-4 / Senna Extract; C8IYT9CR7C / aloe emodin; KA46RNI6HN / Emodin; N1ST8V8RR2 / chrysophanic acid; YM64C2P6UX / rhein
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92. Heo SH, Lee SJ, Ryoo HM, Park JY, Cho JY: Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC-MS/MS. Proteomics; 2007 Dec;7(23):4292-302
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  • Glycoproteins in human serum play fundamental roles in many biological processes, and also have clinical value as biomarkers for disease progression and treatment.
  • We identified several cancer-selective proteins that have been previously characterized as potential indicators of lung cancer in serum or plasma, including haptoglobin (HP), inter-alpha-trypsin inhibitor heavy chain 4 (ITI-H4), complement C3 precursor, and leucine-rich alpha-2-glycoprotein.
  • In addition, plasma kallikrein (KLKB1) and inter-alpha-trypsin inhibitor heavy chain 3 (ITI-H3) were identified as being potentially elevated in the lung cancer group, and were validated by Western blot analysis.
  • [MeSH-minor] Aged. Alpha-Globulins / analysis. Alpha-Globulins / chemistry. Blood Proteins / analysis. Blood Proteins / chemistry. Blotting, Western. Electrophoresis, Polyacrylamide Gel. Gene Expression / physiology. Humans. Lectins / chemistry. Male. Middle Aged. Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase / chemistry. Plasma Kallikrein / analysis. Plasma Kallikrein / chemistry. Reproducibility of Results. Up-Regulation

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  • (PMID = 17963278.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Alpha-Globulins; 0 / Biomarkers, Tumor; 0 / Blood Proteins; 0 / Glycoproteins; 0 / Lectins; 39346-44-6 / inter-alpha-inhibitor; EC 3.4.21.34 / Plasma Kallikrein; EC 3.5.1.52 / Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
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93. Moon C, Kwon YM, Lee WK, Park YJ, Yang VC: In vitro assessment of a novel polyrotaxane-based drug delivery system integrated with a cell-penetrating peptide. J Control Release; 2007 Dec 4;124(1-2):43-50
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  • It is a self-assembled polymer made entirely of biocompatible components, by threading alpha-cyclodextrin (alpha-CD) molecules with the poly(ethylene glycol) (PEG) chain.
  • The abundance in functional -OH groups on the CD residues renders PR the capability of carrying a large dose of small anti-tumor agents for delivery.
  • To facilitate an intracellular uptake by the tumor cells of the PR-DOX conjugates, a cell-penetrating low molecular weight protamine (LMWP) peptide was further attached to the two termini of the PR chain.

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  • (PMID = 17904680.001).
  • [ISSN] 1873-4995
  • [Journal-full-title] Journal of controlled release : official journal of the Controlled Release Society
  • [ISO-abbreviation] J Control Release
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL055461; United States / NHLBI NIH HHS / HL / HL055461-10; United States / NCI NIH HHS / CA / CA114612-03; United States / NHLBI NIH HHS / HL / R01 HL055461-10; United States / NCI NIH HHS / CA / R01 CA114612-03; United States / NCI NIH HHS / CA / R01 CA114612; United States / NHLBI NIH HHS / HL / R01 HL55461
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclodextrins; 0 / Drug Carriers; 0 / Protamines; 0 / Rotaxanes; 0 / polyrotaxane; 106392-12-5 / Poloxamer; 80168379AG / Doxorubicin; ZS7284E0ZP / Daunorubicin
  • [Other-IDs] NLM/ NIHMS35120; NLM/ PMC2211426
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94. Chu YQ, Dai XH, Jiang D, Jiang GY, Fang X, Ding CF: Studies on the non-covalent interactions between cyclodextrins and aryl alkanol piperazine derivatives by mass spectrometry and fluorescence spectroscopy. Rapid Commun Mass Spectrom; 2010 Aug 15;24(15):2255-61
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  • The non-covalent complexes of alpha- and beta-cyclodextrins (alpha-, beta-CDs) with two aryl alkanol piperazine derivatives (Pipe I and Pipe II) have been studied by electrospray ionization mass spectrometry (ESI-MS) and fluorescence spectroscopy.
  • The ESI-MS experimental results demonstrated that Pipe I can conjugate to beta-CD and form 1:1 or 1:2 stoichiometric non-covalent complexes, and Pipe II can only form 1:1 complexes with alpha- or beta-CD.
  • The mass spectrometric titration experiments showed that the dissociation constants K(d1) were 5.77 and 9.52 x 10(-4) mol L(-1) for the complexes of alpha-CD with Pipe I and Pipe II, respectively, revealing that the binding of alpha-CD-Pipe I was stronger than alpha-CD-Pipe II.

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  • [Copyright] Copyright (c) 2010 John Wiley & Sons, Ltd.
  • (PMID = 20623479.001).
  • [ISSN] 1097-0231
  • [Journal-full-title] Rapid communications in mass spectrometry : RCM
  • [ISO-abbreviation] Rapid Commun. Mass Spectrom.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Piperazines
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95. Suzaki Y, Taira T, Osakada K, Horie M: Rotaxanes and pseudorotaxanes with Fe-, Pd- and Pt-containing axles. Molecular motion in the solid state and aggregation in solution. Dalton Trans; 2008 Sep 28;(36):4823-33
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  • An N-alkylbipyridinium forms [3]pseudorotaxane with alpha-cyclodextrin (alpha-CD), and it reacts with platinum and palladium complexes to form the corresponding [5]rotaxanes containing four alpha-cyclodextrin moieties.
  • Complexes without alpha-CD components form micelles in aqueous solution, while the addition of alpha-CD causes degradation of the micelles and the formation of rotaxanes.

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  • (PMID = 18766211.001).
  • [ISSN] 1477-9234
  • [Journal-full-title] Dalton transactions (Cambridge, England : 2003)
  • [ISO-abbreviation] Dalton Trans
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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96. Economidou I, Manousos ON, Triantafillidis JK, Vaslamatzis MM, Zafiropoulou R, Papadakis T: Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania. Eur J Gastroenterol Hepatol; 2006 Sep;18(9):1029-38
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  • [Title] Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania.
  • OBJECTIVES: Immunoproliferative small intestinal disease (IPSID) represents a spectrum of clinicopathological entities including alpha-chain disease and other types of lymphoplasmacytic proliferations of the lamina propria of the small intestine, presenting with severe malabsorption.
  • IPSID has been described mainly in the Mediterranean, Middle East, and African countries.
  • METHODS: Current immunological and immunohistochemical methods for the detection of alpha heavy chains and the presence of clonality have been used to study 13 cases of IPSID diagnosed in Greece, two of whom were Albanian residents.
  • RESULTS: The patients were categorized in three subgroups of IPSID: alpha-chain disease (n=8), non-alpha chain disease with other monoclonal immunoglobulins (n=3), and polyclonal 'non-malignant' IPSID (n=2).
  • In several patients the disease had unusual features, and this in some cases delayed the diagnosis.
  • Patients with stage C disease had a short survival, whereas two patients with stage A alpha-chain disease responded to treatment with cyclophosphamide, vincristine and prednisolone, and cyclophosphamide, doxorubicine, vincristine and prednisolone, respectively, have a disease-free long survival of 35 and 12 years, and appear to be cured.
  • [MeSH-major] Immunoproliferative Small Intestinal Disease / diagnosis

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  • (PMID = 16894320.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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97. Nascimento CS Jr, Anconi CP, Dos Santos HF, De Almeida WB: Theoretical study of the alpha-cyclodextrin dimer. J Phys Chem A; 2005 Apr 14;109(14):3209-19
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  • [Title] Theoretical study of the alpha-cyclodextrin dimer.
  • The molecular structure, stabilization energy, and thermodynamic properties of the plausible modes of the interaction for the three possible alpha-cyclodextrin (alpha-CD) dimers (head-to-head, tail-to-tail, and head-to-tail) with a water cluster were obtained using quantum chemical methods for the first time.
  • The inter alpha-CD hydrogen bonds play a major role to stabilize the dimeric structures, with no water tetramer being found between the two alpha-CD subunits for the preferred global minimum structure.
  • Therefore, a theoretical model aimed to describe the behavior of alpha-CD dimer, or their inclusion complexes, in the aqueous media should take into account this preference for binding of the water molecules.
  • [MeSH-major] Models, Molecular. alpha-Cyclodextrins / chemistry

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  • (PMID = 16833650.001).
  • [ISSN] 1089-5639
  • [Journal-full-title] The journal of physical chemistry. A
  • [ISO-abbreviation] J Phys Chem A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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98. Stroud JL, Paton GI, Semple KT: Predicting the biodegradation of target hydrocarbons in the presence of mixed contaminants in soil. Chemosphere; 2009 Jan;74(4):563-7
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  • The aim of this study was to investigate the prediction of (14)C-phenanthrene and (14)C-hexadecane biodegradation in the presence of other hydrocarbons in soil using beta- and alpha-cyclodextrin (CD) solutions, respectively.
  • Prediction of (14)C-hexadecane using the alpha-CD extraction was robust under single and co-contaminant conditions (r(2)=0.92, slope of best fit line=0.97, intercept=1.24, n=60); however, the alpha-CD could not accurately predict (14)C-hexadecane biodegradation in the presence of multiple contaminants.

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  • (PMID = 19012945.001).
  • [ISSN] 1879-1298
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Hydrocarbons; 0 / Soil; 0 / Soil Pollutants
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99. Wagner EM, Jen KL, Artiss JD, Remaley AT: Dietary alpha-cyclodextrin lowers low-density lipoprotein cholesterol and alters plasma fatty acid profile in low-density lipoprotein receptor knockout mice on a high-fat diet. Metabolism; 2008 Aug;57(8):1046-51
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  • [Title] Dietary alpha-cyclodextrin lowers low-density lipoprotein cholesterol and alters plasma fatty acid profile in low-density lipoprotein receptor knockout mice on a high-fat diet.
  • High dietary intake of saturated fat and cholesterol, and elevated low-density lipoprotein cholesterol levels are some of the modifiable risk factors for cardiovascular disease.
  • Alpha-cyclodextrin (a-CD) when given orally has been shown in rats to increase fecal saturated fat excretion and to reduce blood total cholesterol levels in obese hypertriglyceridemic subjects with type 2 diabetes mellitus.
  • At sacrifice, there was no difference in body weight; but significant decreases were observed in plasma cholesterol (15.3%), free cholesterol (20%), cholesterol esters (14%), and phospholipid (17.5%) levels in mice treated with alpha-CD compared with control mice.
  • Furthermore, alpha-CD improved the blood fatty acid profile, reducing the saturated fatty acids (4.5%) and trans-isomers (11%) while increasing (2.5%) unsaturated fatty acids.
  • In summary, the addition of alpha-CD improved the lipid profile by lowering proatherogenic lipoproteins and trans-fatty acids and by decreasing the ratio of saturated and trans-fatty acids to polyunsaturated fatty acids (-5.8%), thus suggesting that it may be useful as a dietary supplement for reducing cardiovascular disease.
  • [MeSH-major] Atherosclerosis / metabolism. Cholesterol, LDL / blood. Dietary Fats / administration & dosage. Fatty Acids, Nonesterified / blood. Receptors, LDL / metabolism. alpha-Cyclodextrins / pharmacology

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  • (PMID = 18640380.001).
  • [ISSN] 1532-8600
  • [Journal-full-title] Metabolism: clinical and experimental
  • [ISO-abbreviation] Metab. Clin. Exp.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 HL002058-12
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cholesterol Esters; 0 / Cholesterol, LDL; 0 / Dietary Fats; 0 / Fatty Acids, Nonesterified; 0 / Receptors, LDL; 0 / Triglycerides; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
  • [Other-IDs] NLM/ NIHMS63407; NLM/ PMC2597477
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100. Perl A, Kumprecht L, Kraus T, Armspach D, Matt D, Reinhoudt DN, Huskens J: Self-assembled monolayers of alpha-cyclodextrin derivatives on gold and their host-guest behavior. Langmuir; 2009 Feb 3;25(3):1534-9
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  • [Title] Self-assembled monolayers of alpha-cyclodextrin derivatives on gold and their host-guest behavior.
  • Various sulfur-modified alpha-cyclodextrin (alpha-CD) derivatives formed ordered monolayers on gold surfaces as confirmed by water contact angle goniometry, electrochemistry, X-ray photoelectron spectroscopy, and atomic force microscopy measurements.

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  • (PMID = 19125561.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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