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1. Sugihara M, Hufen J, Buss V: Origin and consequences of steric strain in the rhodopsin binding pocket. Biochemistry; 2006 Jan 24;45(3):801-10
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  • To study the origin and the effects of steric strain on the chromophore conformation in rhodopsin, we have performed quantum-mechanical calculations on the wild-type retinal chromophore and four retinal derivatives, 13-demethyl-, 10-methyl-13-demethyl-, 10-methyl-, and 9-demethylretinal.
  • As a result, the polyene chain, from N16 to C13, is twisted in a clockwise manner against the remaining part of the chromophore, leading to a C11=C12 bond with the observed negative dihedral angle.
  • Shifts of the absorption maxima are reproduced correctly, in particular, the red shift of the 10-methyl and the strong blue shift of the 9-demethyl analogue relative to the wild type.
  • Calculated positive rotatory strengths of the alpha-CD bands are in agreement with the calculated absolute conformation of the mutant chromophores.

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  • (PMID = 16411756.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9009-81-8 / Rhodopsin
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2. Kawai-Kowase K, Kumar MS, Hoofnagle MH, Yoshida T, Owens GK: PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins. Mol Cell Biol; 2005 Sep;25(18):8009-23
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  • Although a critical component of vascular disease is modulation of the differentiated state of vascular smooth muscle cells (SMC), the mechanisms governing SMC differentiation are relatively poorly understood.
  • We have previously shown that E-boxes and the ubiquitously expressed class I basic helix-loop-helix (bHLH) proteins, including E2-2 and E12, are important in regulation of the SMC differentiation marker gene, the SM alpha-actin gene.
  • Overexpression of PIAS1 significantly activated the SM alpha-actin promoter and mRNA expression, as well as SM myosin heavy chain and SM22alpha, whereas a small interfering RNA for PIAS1 decreased activity of these promoters, as well as endogenous mRNA expression, and SRF binding to SM alpha-actin promoter within intact chromatin in cultured SMC.
  • Of significance, PIAS1 bound to SRF and activated SM alpha-actin promoter expression in wild-type but not SRF(-/-) embryonic stem cells.

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  • (PMID = 16135793.001).
  • [ISSN] 0270-7306
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R37 HL57353; United States / NHLBI NIH HHS / HL / R01 HL038854; United States / NHLBI NIH HHS / HL / P01 HL019242; United States / NHLBI NIH HHS / HL / P01 HL19242; United States / NHLBI NIH HHS / HL / R01 HL 38854
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / HAND2 protein, human; 0 / Hand1 protein, mouse; 0 / Hand2 protein, mouse; 0 / Hand2 protein, rat; 0 / Muscle Proteins; 0 / PIAS1 protein, human; 0 / Protein Inhibitors of Activated STAT; 0 / RNA, Small Interfering; 0 / Serum Response Factor; 0 / Small Ubiquitin-Related Modifier Proteins; 0 / TCF Transcription Factors; 0 / TCF7L1 protein, human; 0 / TCF7L2 protein, human; 0 / Tcf7l1 protein, mouse; 0 / Tcf7l1 protein, rat; 0 / Tcf7l2 protein, mouse; 0 / Tcf7l2 protein, rat; 0 / Transcription Factor 7-Like 1 Protein; 0 / Transcription Factor 7-Like 2 Protein; 0 / Transcription Factors; 0 / Zebrafish Proteins; 0 / hand2 protein, zebrafish; 0 / helix-loop-helix protein, eHAND
  • [Other-IDs] NLM/ PMC1234309
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3. Economidou I, Manousos ON, Triantafillidis JK, Vaslamatzis MM, Zafiropoulou R, Papadakis T: Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania. Eur J Gastroenterol Hepatol; 2006 Sep;18(9):1029-38
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  • [Title] Immunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albania.
  • OBJECTIVES: Immunoproliferative small intestinal disease (IPSID) represents a spectrum of clinicopathological entities including alpha-chain disease and other types of lymphoplasmacytic proliferations of the lamina propria of the small intestine, presenting with severe malabsorption.
  • IPSID has been described mainly in the Mediterranean, Middle East, and African countries.
  • METHODS: Current immunological and immunohistochemical methods for the detection of alpha heavy chains and the presence of clonality have been used to study 13 cases of IPSID diagnosed in Greece, two of whom were Albanian residents.
  • RESULTS: The patients were categorized in three subgroups of IPSID: alpha-chain disease (n=8), non-alpha chain disease with other monoclonal immunoglobulins (n=3), and polyclonal 'non-malignant' IPSID (n=2).
  • In several patients the disease had unusual features, and this in some cases delayed the diagnosis.
  • Patients with stage C disease had a short survival, whereas two patients with stage A alpha-chain disease responded to treatment with cyclophosphamide, vincristine and prednisolone, and cyclophosphamide, doxorubicine, vincristine and prednisolone, respectively, have a disease-free long survival of 35 and 12 years, and appear to be cured.
  • [MeSH-major] Immunoproliferative Small Intestinal Disease / diagnosis

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  • (PMID = 16894320.001).
  • [ISSN] 0954-691X
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone
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4. Jiang XJ, Wang T, Li XY, Wu DQ, Zheng ZB, Zhang JF, Chen JL, Peng B, Jiang H, Huang C, Zhang XZ: Injection of a novel synthetic hydrogel preserves left ventricle function after myocardial infarction. J Biomed Mater Res A; 2009 Aug;90(2):472-7
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  • After 1 week, 200-microL alpha-cyclodextrin (alpha-CD)/MPEG-PCL-MPEG hydrogel was injected into the infarcted myocardium.
  • These results suggest that alpha-CD/MPEG-PCL-MPEG hydrogel could serve as an injectable biomaterial that prevents LV remodeling and dilation for the treatment of MI.

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  • (PMID = 18546187.001).
  • [ISSN] 1552-4965
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Hydrogels; 0 / Polyesters; 0 / methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol); 25852-47-5 / Hydrogel; 30IQX730WE / Polyethylene Glycols
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5. Fakhari AR, Nojavan S, Haghgoo S, Mohammadi A: Development of a stability-indicating CE assay for the determination of amlodipine enantiomers in commercial tablets. Electrophoresis; 2008 Nov;29(22):4583-92
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  • Several types of CD were evaluated and best results were obtained using a fused-silica capillary with phosphate running buffer (100 mM, pH 3.0) containing 5 mM hydroxypropyl-alpha-CD.

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  • (PMID = 18985664.001).
  • [ISSN] 1522-2683
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Buffers; 0 / Cyclodextrins; 0 / Tablets; 1J444QC288 / Amlodipine
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6. Hsueh YH, Huang JL, Tseng MC, Her GR: Sensitivity improvement of CE/ESI/MS analysis of gangliosides using a liquid-junction/low-flow interface. Electrophoresis; 2010 Apr;31(7):1138-43
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  • Specifically, alpha-CD, used to break up ganglioside micelle formation, was replaced with isopropyl alcohol.
  • [MeSH-minor] Borates / chemistry. Equipment Design. Sensitivity and Specificity. Sodium. alpha-Cyclodextrins / chemistry

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  • (PMID = 20209568.001).
  • [ISSN] 1522-2683
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Borates; 0 / Gangliosides; 0 / alpha-Cyclodextrins; 9NEZ333N27 / Sodium
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7. Song le X, Wang HM, Xu P, Yang Y, Zhang ZQ: Experimental and theoretical studies on the inclusion complexation of syringic acid with alpha-, beta-, gamma- and heptakis(2,6-di-O-methyl)-beta-cyclodextrin. Chem Pharm Bull (Tokyo); 2008 Apr;56(4):468-74
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  • [Title] Experimental and theoretical studies on the inclusion complexation of syringic acid with alpha-, beta-, gamma- and heptakis(2,6-di-O-methyl)-beta-cyclodextrin.
  • Intermolecular interactions of alpha-, beta-, gamma- and heptakis(2,6-di-O-methyl)-beta-cyclodextrin (CD) with syringic acid (Syr) in aqueous solution are investigated by fluorescence spectroscopy.
  • The association abilities of Syr with the CDs decrease in the order gamma->beta->alpha- approximately DMbeta-CD.
  • Based on the results of NMR experimental and theoretical PM3 calculations both in vacuo and in water, it is found that Syr stays near the wider rim of alpha-CD cavity.
  • Both the number of substituted groups (NSG) in a guest and the molar volume ratio of the guest to host cavity (MVR) play an important role in forming the CD supramolecular complexes of a homologous series of phenol derivatives, such as 2-methoxylphenol (2-Mop), eugenol (Eug) and Syr, i.e., an appropriate NSG or MVR in an inclusion system, such as in 2-Mop-alpha-CD, Eug-beta-CD and Syr-gamma-CD systems, can maximize the intermolecular interaction between host and guest.

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  • (PMID = 18379092.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Drug Carriers; 0 / Indicators and Reagents; 0 / Solutions; 632XD903SP / Gallic Acid; E390O181H5 / syringic acid
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8. Zhou Q, Amar S: Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infect Immun; 2006 Feb;74(2):1204-14
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  • To characterize the roles of Porphyromonas gingivalis and its components in disease processes, we investigated the cytokine profiles induced by live P. gingivalis, its lipopolysaccharide (LPS), and its major fimbrial protein, fimbrillin (FimA).
  • As expected, an extensive repertoire of inflammatory mediators increased subsequent to infection, most predominantly tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, IL-10, and granulocyte-macrophage colony-stimulating factor.
  • The expression of proteins involved in gene transcription (e.g., monocyte enhancer factor 2D [MEF2D], signal transducer and activator of transcription 1 [STAT1], STAT3, STAT6, and IL enhancer binding factors [ILF3]), of protein kinases (e.g., mitogen-activated protein kinase 3 [MAPK3], MAP3K8, double-stranded RNA-activated protein kinase [PRKR], and MAP2K4), and of proteins involved in immune responses (e.g., TNF super family member 6 [TNFSF6] and interferon-induced protein with tetratricopeptide repeat 4 [IFIT4]), apoptosis (e.g., genes associated with retinoid interferon-induced mortality 19 [GRIM19]), and other fundamental cellular processes (e.g., clathrin heavy-chain polypeptide, culreticulin, and Ras-associated protein RAB27A) was found to be modulated differentially by P. gingivalis, LPS, and FimA.


9. Wu YL, Li J: Synthesis of supramolecular nanocapsules based on threading of multiple cyclodextrins over polymers on gold nanoparticles. Angew Chem Int Ed Engl; 2009;48(21):3842-5
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  • The CD's stuck: Poly(ethylene glycol) chains anchored onto gold nanoparticles (AuNPs) are threaded by multiple alpha-cyclodextrin (alpha-CD) rings to form a supramolecular outer layer composed of pseudopolyrotaxane columns perpendicular to the nanoparticle surface.
  • Capping the polymer ends confines alpha-CD on the nanoparticle surface, cross-linking the alpha-CD rings and then removing the AuNP cores produces supramolecular nanocapsules.

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  • (PMID = 19378311.001).
  • [ISSN] 1521-3773
  • [Journal-full-title] Angewandte Chemie (International ed. in English)
  • [ISO-abbreviation] Angew. Chem. Int. Ed. Engl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Cyclodextrins; 0 / Nanocapsules; 0 / Polymers; 7440-57-5 / Gold
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10. Xu Y, Williams SJ, O'Brien D, Davidge ST: Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring. FASEB J; 2006 Jun;20(8):1251-3
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  • Intrauterine growth restriction (IUGR) increases the risk of developing adult-onset cardiovascular disease.
  • In 4-mo IUGR-H offspring, left ventricular wt/body wt ratio (LVW/BW) and right ventricular wt/BW ratio (RVW/BW) increased, in association with increased collagen I and III expression, beta and alpha myosin heavy chain (beta/alphaMHC) ratio, and decreased matrix metalloproteinase (MMP)-2 activity compared to the other groups.
  • At 7 mo, both IUGR-H and IUGR-NR offspring had increased LVW/BW, collagen I and III, beta/alpha MHC ratio, and decreased cardiac recovery and MMP-2 activity compared to control.
  • [MeSH-minor] Animals. Anoxia / complications. Blood Pressure. Body Weight. Female. Fetal Nutrition Disorders / etiology. Fibrillar Collagens / metabolism. Fibrillar Collagens / ultrastructure. Heart / physiopathology. Heart Ventricles / pathology. L-Lactate Dehydrogenase / analysis. Male. Matrix Metalloproteinase 2 / metabolism. Myosin Heavy Chains / metabolism. Organ Culture Techniques. Pregnancy. Rats. Rats, Sprague-Dawley

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  • (PMID = 16632594.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrillar Collagens; EC 1.1.1.27 / L-Lactate Dehydrogenase; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.6.4.1 / Myosin Heavy Chains
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11. Pai RK, Snider WK, Starkey CR, Viswanatha D, Foucar MK, Wilson CS: Nonsecretory variant of immunoproliferative small intestinal disease: a case report with pathologic, immunophenotypic, and molecular findings. Arch Pathol Lab Med; 2005 Nov;129(11):1487-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonsecretory variant of immunoproliferative small intestinal disease: a case report with pathologic, immunophenotypic, and molecular findings.
  • We report a case of the nonsecretory variant of immunoproliferative small intestinal disease involving the distal small bowel and the mesenteric and retroperitoneal lymph nodes in a 19-year-old woman from Mexico.
  • This variant extranodal marginal zone B-cell lymphoma appeared similar in the different sites of involvement, with more interspersed large cells and greater plasmacytic differentiation present in intestinal specimens.
  • Characteristic lymphoepithelial lesions and follicular colonization were seen in intestinal and lymph node sections, respectively.
  • The neoplastic B cells were cytoplasmic immunoglobulin (Ig) A heavy-chain restricted and lacked surface and cytoplasmic light-chain expression by flow cytometric analysis.
  • Molecular studies showed absence of immunoglobulin heavy-chain (IgH) gene rearrangement, with a nonfunctional clonotypic rearrangement of the kappa light-chain gene.
  • This case highlights the role for kappa light-chain gene evaluation in immunoproliferative small intestinal disease, because IgH gene rearrangement analysis is often negative.
  • [MeSH-major] Immunoproliferative Small Intestinal Disease / pathology. Lymph Nodes / pathology. Lymphoma, B-Cell, Marginal Zone / pathology
  • [MeSH-minor] 2-Pyridinylmethylsulfinylbenzimidazoles. Adult. Amoxicillin / therapeutic use. Anti-Bacterial Agents / therapeutic use. Benzimidazoles / therapeutic use. Drug Therapy, Combination. Female. Gene Rearrangement, B-Lymphocyte, Light Chain / genetics. Humans. Immunophenotyping. Intestine, Small / pathology. Mesentery. Metronidazole / therapeutic use. Omeprazole / analogs & derivatives. Omeprazole / therapeutic use. Retroperitoneal Space. Sulfoxides / therapeutic use

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  • (PMID = 16253033.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2-Pyridinylmethylsulfinylbenzimidazoles; 0 / Anti-Bacterial Agents; 0 / Benzimidazoles; 0 / Sulfoxides; 140QMO216E / Metronidazole; 804826J2HU / Amoxicillin; D8TST4O562 / pantoprazole; KG60484QX9 / Omeprazole
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12. Li X, Li J: Supramolecular hydrogels based on inclusion complexation between poly(ethylene oxide)-b-poly (epsilon-caprolactone) diblock copolymer and alpha-cyclodextrin and their controlled release property. J Biomed Mater Res A; 2008 Sep 15;86(4):1055-61
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  • [Title] Supramolecular hydrogels based on inclusion complexation between poly(ethylene oxide)-b-poly (epsilon-caprolactone) diblock copolymer and alpha-cyclodextrin and their controlled release property.
  • Supramolecular hydrogels formed through inclusion complexation between high molecular weight poly(ethylene oxide) (PEO) and alpha-cyclodextrin (alpha-CD) showed the most sustained release kinetics in vitro with molecular weight of PEO of 35,000 within 5 days.
  • Compared with that of alpha-CD/PEO supramolecular hydrogels, the sustained release of alpha-CD/PEO-PCL supramolecular hydrogel was increased significantly even if with much lower molecular weight of PEO block.
  • The sustained release is also dependent on the alpha-CD content in supramolecular hydrogels.
  • Thus, the properties of supramolecular hydrogel can be fine-tuned with different polymer and at different alpha-CD content, opening a wide range of applications.
  • [MeSH-major] Drug Delivery Systems. Hydrogels / chemistry. Lactones / chemistry. Polyethylene Glycols / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 18067162.001).
  • [ISSN] 1552-4965
  • [Journal-full-title] Journal of biomedical materials research. Part A
  • [ISO-abbreviation] J Biomed Mater Res A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydrogels; 0 / Lactones; 0 / alpha-Cyclodextrins; 0 / poly(ethylene oxide)-b-poly(caprolactone); 30IQX730WE / Polyethylene Glycols; I223NX31W9 / Fluorescein-5-isothiocyanate; K3R6ZDH4DU / Dextrans; Z1LH97KTRM / alpha-cyclodextrin
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13. Yamauchi K, Miyawaki A, Takashima Y, Yamaguchi H, Harada A: Switching from altro-alpha-cyclodextrin dimer to pseudo[1]rotaxane dimer through tumbling. Org Lett; 2010 Mar 19;12(6):1284-6
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  • [Title] Switching from altro-alpha-cyclodextrin dimer to pseudo[1]rotaxane dimer through tumbling.
  • An alkyl altro-alpha-CD dimer was converted to the pseudo[1]rotaxane dimer through tumbling of the altropyranose unit of altro-alpha-CD in D(2)O.
  • The activation free energy (DeltaG(double dagger)(288K)) for the conformational change from an alkyl altro-alpha-CD dimer to pseudo[1]rotaxane dimer was 88.0 kJ mol(-1), which corresponds to the breakage of the hydrogen bond network for the tumbling of an altropyranose unit.
  • [MeSH-major] Rotaxanes / chemical synthesis. alpha-Cyclodextrins / chemistry

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  • (PMID = 20180513.001).
  • [ISSN] 1523-7052
  • [Journal-full-title] Organic letters
  • [ISO-abbreviation] Org. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Rotaxanes; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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14. Wen Q, Zhou CY, Zhou MQ, Luo W, Ma L: [Differentiation of 5-azacytidine-induced bone marrow stromal stem cells transduced with hepatocyte growth factor gene]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Jul;30(7):1537-40
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  • Morphological observation and immunohistochemistry were performed to detect the expression of the markers of cardiomyocyte-like cells including beta-myosin heavy chain (beta-MHC) and alpha-sarcomeric actin.
  • CONCLUSION: Ad-HGF can efficiently transfect BMSCs induced with 5-azacytidine, and this result provides basic experimental evidence for biotherapy of ischemic heart disease using BMSCs.

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  • (PMID = 20650760.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
  • [Chemical-registry-number] 67256-21-7 / Hepatocyte Growth Factor; M801H13NRU / Azacitidine
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15. Blyszczuk P, Kania G, Dieterle T, Marty RR, Valaperti A, Berthonneche C, Pedrazzini T, Berger CT, Dirnhofer S, Matter CM, Penninger JM, Lüscher TF, Eriksson U: Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circ Res; 2009 Oct 23;105(9):912-20
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  • RATIONALE: The myeloid differentiation factor (MyD)88/interleukin (IL)-1 axis activates self-antigen-presenting cells and promotes autoreactive CD4(+) T-cell expansion in experimental autoimmune myocarditis, a mouse model of inflammatory heart disease.
  • METHODS AND RESULTS: Using alpha-myosin heavy chain peptide (MyHC-alpha)-loaded, activated dendritic cells, we induced myocarditis in wild-type and MyD88(-/-) mice with similar distributions of heart-infiltrating cell subsets and comparable CD4(+) T-cell responses.
  • Injection of complete Freund's adjuvant (CFA) or MyHC-alpha/CFA into diseased mice promoted cardiac fibrosis, induced ventricular dilation, and impaired heart function in wild-type but not in MyD88(-/-) mice.
  • Experiments with chimeric mice confirmed the bone marrow origin of the fibroblasts replacing inflammatory infiltrates and showed that MyD88 and IL-1 receptor type I signaling on bone marrow-derived cells was critical for development of cardiac fibrosis during progression to heart failure.
  • [MeSH-minor] Animals. Autoimmunity. Bone Marrow Transplantation. CD4-Positive T-Lymphocytes / immunology. Cells, Cultured. Dendritic Cells / immunology. Dendritic Cells / transplantation. Disease Models, Animal. Disease Progression. Fibroblasts / immunology. Fibrosis. Freund's Adjuvant. Green Fluorescent Proteins / genetics. Immunity, Innate. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Knockout. Mice, Transgenic. Myosin Heavy Chains / immunology. Phenotype. Receptors, Interleukin-1 Type I / genetics. Receptors, Interleukin-1 Type I / metabolism. Transplantation Chimera

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  • (PMID = 19762681.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-1beta; 0 / Myd88 protein, mouse; 0 / Myeloid Differentiation Factor 88; 0 / Receptors, Interleukin-1 Type I; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; 9007-81-2 / Freund's Adjuvant; EC 3.6.4.1 / Myosin Heavy Chains
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16. Han M, Wen JK, Zheng B, Cheng Y, Zhang C: Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells. Am J Physiol Cell Physiol; 2006 Jul;291(1):C50-8
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  • Expressions of VSMC-specific contractile proteins, such as smooth muscle (SM) alpha-actin, SM-myosin heavy chain, calponin, and SM 22alpha, were increased and reached the levels in differentiated cells after serum deprivation.
  • Furthermore, the phenotypic reversion was markedly inhibited by decoy double-strand oligodeoxynucleotides containing SM alpha-actin CArG motif, which was able to competitively bind to SRF.
  • This novel model of VSMC phenotypic reversion should be valuable for research on vascular disease.

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  • (PMID = 16467401.001).
  • [ISSN] 0363-6143
  • [Journal-full-title] American journal of physiology. Cell physiology
  • [ISO-abbreviation] Am. J. Physiol., Cell Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-72902
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media, Serum-Free; 0 / Serum Response Factor
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17. Balan B, Gopidas KR: Photoinduced electron transfer in alpha-cyclodextrin-based supramolecular dyads: a free-energy-dependence study. Chemistry; 2006 Aug 25;12(25):6701-10
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  • [Title] Photoinduced electron transfer in alpha-cyclodextrin-based supramolecular dyads: a free-energy-dependence study.
  • Photoinduced electron transfer (PET) between alpha-cyclodextrin-appended pyrene (PYCD) and a few acceptor molecules was studied in aqueous solutions.
  • The pyrene moiety in PYCD is located above the narrower rim of the alpha-CD and is fully exposed to water.

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  • (PMID = 16800017.001).
  • [ISSN] 0947-6539
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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18. Liu J, Sondjaja HR, Tam KC: Alpha-cyclodextrin-induced self-assembly of a double-hydrophilic block copolymer in aqueous solution. Langmuir; 2007 Apr 24;23(9):5106-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alpha-cyclodextrin-induced self-assembly of a double-hydrophilic block copolymer in aqueous solution.
  • Double-hydrophilic poly(ethylene oxide)-b-poly(acrylic acid) (PEO-b-PAA) self-assembled into nanostructures in basic solution upon the addition of alpha-cyclodextrin (alpha-CD) as a result of the complexation between alpha-CD and PEO.
  • The nanostructures produced were spherical in shape as observed by transmission electron microscopy (TEM) and possessed radii that were much larger than that of a single stretched polymeric chain.
  • The above results suggested that the nanostructures formed in the PEO-b-PAA/alpha-CD solution at high pH were likely to be spherical vesicles.

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  • (PMID = 17391053.001).
  • [ISSN] 0743-7463
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Baer AJ, Macartney DH: Orientational isomers of alpha-cyclodextrin [2]semi-rotaxanes with asymmetric dicationic threads. Org Biomol Chem; 2005 Apr 21;3(8):1448-52
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  • [Title] Orientational isomers of alpha-cyclodextrin [2]semi-rotaxanes with asymmetric dicationic threads.
  • Two series of novel dicationic threading molecules [Quin(CH2)10R]2+ and [3,5-Lut(CH2)10R]2+, where Quin+ = quinuclidinium, 3,5-Lut+ = 3,5-lutidinium, and R+ = N(CH3)3+ and N(CH3)2CH2CH3+, form [2]semi-rotaxanes with [small alpha]-cyclodextrin (alpha-CD) in aqueous solution.
  • The quinuclidinium and 3,5-lutidinium are sufficiently bulky to prevent threading while the R+ groups allow for slow threading by alpha-CD at 25 degrees C.
  • The resulting [2]semi-rotaxanes exist in two orientational isomers owing to the asymmetry of both the alpha-CD cavity and the threading molecules.

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  • (PMID = 15827640.001).
  • [ISSN] 1477-0520
  • [Journal-full-title] Organic & biomolecular chemistry
  • [ISO-abbreviation] Org. Biomol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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20. Sekine H, Shimizu T, Yang J, Kobayashi E, Okano T: Pulsatile myocardial tubes fabricated with cell sheet engineering. Circulation; 2006 Jul 4;114(1 Suppl):I87-93
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  • METHODS AND RESULTS: Neonatal rat cardiomyocyte sheets were sequentially wrapped around a resected adult rat thoracic aorta and transplanted in place of the abdominal aorta of athymic rats (n=17).
  • Finally, when myocardial tubes used for aortic replacement were compared with grafts implanted in the abdominal cavity (n=7), we observed significantly increased tissue thickness, as well as expression of brain natriuretic peptide, myosin heavy chain-alpha, and myosin heavy chain-beta.
  • [MeSH-major] Aorta, Abdominal / surgery. Myocardial Contraction. Myocardium / cytology. Myocytes, Cardiac / transplantation. Tissue Engineering / methods
  • [MeSH-minor] Animals. Animals, Newborn. Aorta, Thoracic / transplantation. Cell Culture Techniques / instrumentation. Cells, Cultured / transplantation. Electrocardiography. Gene Expression Profiling. Microsurgery. Myosin Heavy Chains / biosynthesis. Myosin Heavy Chains / genetics. Natriuretic Peptide, Brain / biosynthesis. Natriuretic Peptide, Brain / genetics. Organ Culture Techniques. Rats. Rats, Nude. Rats, Wistar. Temperature

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  • (PMID = 16820651.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bmyo protein, rat; 0 / natriuretic peptide precursor type B, rat; 114471-18-0 / Natriuretic Peptide, Brain; EC 3.6.4.1 / Myosin Heavy Chains
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21. Kandoth N, Choudhury SD, Mukherjee T, Pal H: Host-guest interaction of 1,4-dihydroxy-9,10-anthraquinone (quinizarin) with cyclodextrins. Photochem Photobiol Sci; 2009 Jan;8(1):82-90
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  • The interaction of 1,4-dihydroxy-9,10-anthraquinone, (quinizarin; QZ), with alpha-, beta- and gamma-cyclodextrin (CD) hosts, has been investigated using absorption, and steady-state and time-resolved fluorescence measurements, in order to understand the effects of cavity size of CDs on the binding of QZ molecule and the changes in the photophysical properties of QZ in the microenvironment of the hosts.
  • It is proposed that the unsubstituted benzene ring of QZ is encapsulated within alpha- and beta-CD cavities whereas the dihydroxy-substituted aromatic ring is encapsulated within the gamma-CD cavity.
  • It is observed that the complexation of QZ with the metal ion is enhanced in the QZ.alpha-CD and QZ.beta-CD systems whereas it is significantly reduced in the QZ.gamma-CD system, due to shielding of the chelating groups of the dye inside the CD cavity in the latter case.

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  • (PMID = 19247534.001).
  • [ISSN] 1474-905X
  • [Journal-full-title] Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • [ISO-abbreviation] Photochem. Photobiol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthraquinones; 0 / Cyclodextrins; 8S496ZV3CS / 1,4-dihydroxyanthraquinone
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22. Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, Oresic M, Alitalo K: Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res; 2008 Oct 24;103(9):1018-26
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  • We produced mice expressing a cardiac-specific VEGF-B transgene via the alpha-myosin heavy chain promoter.

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  • (PMID = 18757827.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL075183-02; United States / NHLBI NIH HHS / HL / R01 HL075183; United States / NHLBI NIH HHS / HL / 5-R01-HL075183-02; United States / NHLBI NIH HHS / HL / R01 HL075183-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ceramides; 0 / Triglycerides; 0 / VEGFB protein, human; 0 / Vascular Endothelial Growth Factor B; 11128-99-7 / Angiotensin II; EC 3.6.1.- / Ventricular Myosins; EC 3.6.4.1 / Myosin Heavy Chains
  • [Other-IDs] NLM/ NIHMS136540; NLM/ PMC2762522
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23. Paau MC, Lo CK, Yang X, Choi MM: Capillary electrophoretic study of thiolated alpha-cyclodextrin-capped gold nanoparticles with tetraalkylammonium ions. J Chromatogr A; 2009 Nov 27;1216(48):8557-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Capillary electrophoretic study of thiolated alpha-cyclodextrin-capped gold nanoparticles with tetraalkylammonium ions.
  • Capillary zone electrophoresis (CZE) has been employed to characterize nanometer-sized thiolated alpha-cyclodextrin-capped gold nanoparticles (alpha-CD-S-AuNPs).
  • The addition of tetrabutylammonium (Bu(4)N(+)) ions to the run buffer greatly narrows the migration peak of alpha-CD-S-AuNP.
  • The effect of various tetraalkylammonium ions on the peak width and electrophoretic mobility (mu(e)) of alpha-CD-S-AuNP was studied in detail.
  • Bu(4)N(+) ions assist in inter-linking the alpha-CD-S-AuNPs and narrowing the migration peak in CZE.
  • This observation can be explained by the fact that each Bu(4)N(+) ion can simultaneously interact with several hydrophobic cavities of the surface-attached alpha-CDs on AuNPs.
  • The TEM images show that alpha-CD-S-AuNPs with Bu(4)N(+) are linked together but in the absence of Bu(4)N(+), they are more dispersed.
  • The migration mechanism in CZE is based on the formation of inclusion complexes between Bu(4)N(+) and alpha-CD-S-AuNPs which induces changes in the charge-to-size ratio of alpha-CD-S-AuNPs and mu(e).
  • An inverse linear relationship (r(2)>0.998) exists between the mu(e) and size of alpha-CD-S-AuNPs in the core range 1.4-4.1 nm.
  • A few nanoliters of each of the alpha-CD-S-AuNP samples were injected hydrodynamically at 0.5 psi for 5s.
  • Our work confirms that CZE is an efficient tool for characterizing the sizes of alpha-CD-S-AuNPs using Bu(4)N(+) ions.
  • [MeSH-major] Electrophoresis, Capillary / methods. Gold / chemistry. Metal Nanoparticles / chemistry. Quaternary Ammonium Compounds / chemistry. Sulfhydryl Compounds / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 19853853.001).
  • [ISSN] 1873-3778
  • [Journal-full-title] Journal of chromatography. A
  • [ISO-abbreviation] J Chromatogr A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Buffers; 0 / Ions; 0 / Quaternary Ammonium Compounds; 0 / Sulfhydryl Compounds; 0 / alpha-Cyclodextrins; 7440-57-5 / Gold; CBU2X6BBJR / tetrabutylammonium; Z1LH97KTRM / alpha-cyclodextrin
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24. Tang Y, Urs S, Boucher J, Bernaiche T, Venkatesh D, Spicer DB, Vary CP, Liaw L: Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation. J Biol Chem; 2010 Jun 4;285(23):17556-63
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  • Notch and transforming growth factor-beta (TGFbeta) play pivotal roles during vascular development and the pathogenesis of vascular disease.
  • Activation of Notch signaling using Notch intracellular domain or Jagged1 ligand induced smooth muscle alpha-actin (SM actin), smooth muscle myosin heavy chain, and calponin1, and the expression of Notch downstream effectors hairy-related transcription factors.
  • Similarly, TGFbeta1 treatment of human aortic smooth muscle cells induced SM actin, calponin1, and smooth muscle protein 22-alpha (SM22alpha) in a dose- and time-dependent manner.

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  • [ErratumIn] J Biol Chem. 2012 Jan 6;287(2):1609
  • (PMID = 20368328.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL083151; United States / NCRR NIH HHS / RR / P20RR15555; United States / NCRR NIH HHS / RR / P20 RR015555; United States / NHLBI NIH HHS / HL / R01 HL070865; United States / NCRR NIH HHS / RR / P20RR18789
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ligands; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / Receptor, Notch1; 0 / Transforming Growth Factor beta; 0 / calponin; 134324-36-0 / Serrate proteins
  • [Other-IDs] NLM/ PMC2878520
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25. Yazdanparast R, Esmaeili MA, Khodagholi F: Control of aggregation in protein refolding: cooperative effects of artificial chaperone and cold temperature. Int J Biol Macromol; 2007 Jan 30;40(2):126-33
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  • In both techniques, it was found that CTAB is a better additive (in dilution mode) or a capturing agent (in artificial chaperone method).
  • In dilution, using CTAB or alpha-cyclodextrin (alpha-CD) as two different additives, the aggregation was inhibited by almost 55%.
  • However, the extent of inhibition raised to almost 82% in artificial chaperone assisted mode using CTAB as the capturing and alpha-CD as the stripping agents.
  • [MeSH-minor] Guanidine / pharmacology. Humans. Protein Denaturation. Protein Renaturation. alpha-Cyclodextrins / pharmacology

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  • (PMID = 16875728.001).
  • [ISSN] 0141-8130
  • [Journal-full-title] International journal of biological macromolecules
  • [ISO-abbreviation] Int. J. Biol. Macromol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cetrimonium Compounds; 0 / alpha-Cyclodextrins; 9002-72-6 / Growth Hormone; JU58VJ6Y3B / Guanidine; Z1LH97KTRM / alpha-cyclodextrin; Z7FF1XKL7A / cetrimonium
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26. Rice R, Guinto P, Dowell-Martino C, He H, Hoyer K, Krenz M, Robbins J, Ingwall JS, Tardiff JC: Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts. J Mol Cell Cardiol; 2010 May;48(5):979-88
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  • [Title] Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts.
  • Familial hypertrophic cardiomyopathy, FHC, is a clinically heterogeneous, autosomal-dominant disease of the cardiac sarcomere leading to extensive remodeling at both the whole heart and molecular levels.
  • The remodeling patterns are mutation-specific, a finding that extends to the level of single amino acid substitutions at the same peptide residue.
  • To determine if a greater economy of contraction at the crossbridge level would rescue the mechanical defects caused by the R92 cTnT mutations, we replaced the endogenous murine alpha-myosin heavy chain (MyHC) with the beta-MyHC isoform.

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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  • (PMID = 20004663.001).
  • [ISSN] 1095-8584
  • [Journal-full-title] Journal of molecular and cellular cardiology
  • [ISO-abbreviation] J. Mol. Cell. Cardiol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL075619-06; United States / NHLBI NIH HHS / HL / R01-HL-075619-06; United States / NHLBI NIH HHS / HL / F31 HL085915; United States / NHLBI NIH HHS / HL / 5F31-HL-085915-04; United States / NHLBI NIH HHS / HL / R01 HL075619-06; United States / NHLBI NIH HHS / HL / R01 HL075619; United States / NHLBI NIH HHS / HL / R01 HL107046
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Isoforms; 0 / Troponin T; EC 3.6.4.1 / Myosin Heavy Chains; SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS164849; NLM/ PMC3016872
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27. Cheng G, Zhao X, Yan W, Wang W, Zuo X, Huang K, Liu Y, Chen J, Wang J, Cong W, Liu M, Gao H, Chen J, Lu Y, Zheng Z: Alpha interferon is a powerful adjuvant for a recombinant protein vaccine against foot-and-mouth disease virus in swine, and an effective stimulus of in vivo immune response. Vaccine; 2007 Jul 9;25(28):5199-208
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  • [Title] Alpha interferon is a powerful adjuvant for a recombinant protein vaccine against foot-and-mouth disease virus in swine, and an effective stimulus of in vivo immune response.
  • The adjuvant effect of porcine interferon-alpha (PoIFN-alpha) was examined in swine vaccinated with a recombinant FMD protein vaccine named IgG-FMDV, which contains the swine IgG single heavy chain constant region and an immunogenic peptide of serotype O FMDV.
  • The PoIFN-alpha gene was cloned into pcDNA3 vector and the recombinant plasmid was incorporated into cationic liposomes by a dehydration and rehydration procedure to use as an adjuvant, injected together with low-dose IgG-FMDV.
  • As an adjuvant for the protein vaccine, PoIFN-alpha induced strong inflammatory cytokines production in vivo and the results denoted that IFN-adjuvant and our vaccines could drive the immune response toward Th1 type responses.
  • Our studies indicate that porcine IFN-alpha is a powerful adjuvant for recombinant FMD protein vaccine and could aid in vaccination against FMDV in swine.
  • [MeSH-major] Foot-and-Mouth Disease Virus / immunology. Interferon-alpha / immunology. Recombinant Fusion Proteins / immunology. Viral Vaccines / immunology
  • [MeSH-minor] Adjuvants, Immunologic / administration & dosage. Animals. Antibodies, Viral / blood. Cell Line. Cell Proliferation / drug effects. Cytokines / genetics. Cytokines / metabolism. Foot-and-Mouth Disease / blood. Foot-and-Mouth Disease / immunology. Foot-and-Mouth Disease / prevention & control. Gene Expression / drug effects. Immunoglobulin G / genetics. Immunoglobulin G / immunology. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Swine. Swine Diseases / immunology. Swine Diseases / prevention & control. Swine Diseases / virology. T-Lymphocytes / cytology. T-Lymphocytes / immunology. T-Lymphocytes / metabolism. Viral Proteins / genetics. Viral Proteins / immunology

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  • (PMID = 17555848.001).
  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Antibodies, Viral; 0 / Cytokines; 0 / Immunoglobulin G; 0 / Interferon-alpha; 0 / RNA, Messenger; 0 / Recombinant Fusion Proteins; 0 / Viral Proteins; 0 / Viral Vaccines
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28. Yamagaki T, Sato A: Peak width-mass correlation in CID MS/MS of isomeric oligosaccharides using traveling-wave ion mobility mass spectrometry. J Mass Spectrom; 2009 Oct;44(10):1509-17
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  • The twIM peak width (ms-micros) of the product ions [M-Glc(n) + H]+ (n = 0-6) of gamma-CD correlated linearly with their masses (Da); the large and/or long chain product ions had wider peak widths, which were much wider than those from the general diffusion effect.

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  • [Copyright] Copyright 2009 John Wiley & Sons, Ltd.
  • (PMID = 19753613.001).
  • [ISSN] 1096-9888
  • [Journal-full-title] Journal of mass spectrometry : JMS
  • [ISO-abbreviation] J Mass Spectrom
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Oligosaccharides
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29. López-Nicolás JM, Andreu-Sevilla AJ, Carbonell-Barrachina AA, García-Carmona F: Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice. J Agric Food Chem; 2009 Oct 28;57(20):9668-75
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  • [Title] Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice.
  • Even though the addition of alpha-CD had a significant effect on both the concentration of individual volatile compounds and their grouping, only the highest concentration, 90 mM, prevented the oxidation of the volatile precursors present in freshly squeezed juice.
  • The addition of alpha-CD at 90 mM resulted in pear juices with the best color but with low aromatic intensity and low sensory quality.
  • On the other hand, the addition of alpha-CD at 15 mM led to a pear juice also with an acceptable color but at the same time with a high intensity of fruity and pear-like odors/aromas, making it the best appreciated juice by the panel.
  • [MeSH-major] Beverages / analysis. Food Additives / pharmacology. Pigmentation / drug effects. Pyrus / chemistry. Taste / drug effects. Volatile Organic Compounds / analysis. alpha-Cyclodextrins / pharmacology

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  • (PMID = 19799384.001).
  • [ISSN] 1520-5118
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Food Additives; 0 / Volatile Organic Compounds; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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30. Suzuki Y, Tanaka M, Sohmiya M, Ichinose S, Omori A, Okamoto K: Identification of nitrated proteins in the normal rat brain using a proteomics approach. Neurol Res; 2005 Sep;27(6):630-3
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  • BACKGROUND: The nitration of tyrosine has been suggested to play a role in the pathogenesis of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD).
  • METHODS: In the present study, we identified four targets of protein nitration, T-complex polypeptide 1 alpha subunit (TCP-1), neurofilament L (NFL), glial fibrillary acidic protein (GFAP) and clathrin heavy chain (CHC), in the normal rat cortex using a proteomics approach.
  • [MeSH-minor] Amino Acid Sequence. Animals. Blotting, Western. Chaperonin Containing TCP-1. Chaperonins / isolation & purification. Chaperonins / metabolism. Chromatography, High Pressure Liquid / methods. Clathrin Heavy Chains / isolation & purification. Clathrin Heavy Chains / metabolism. Electrophoresis, Gel, Two-Dimensional / methods. Glial Fibrillary Acidic Protein / isolation & purification. Glial Fibrillary Acidic Protein / metabolism. Male. Neurofilament Proteins / isolation & purification. Neurofilament Proteins / metabolism. Rats. Rats, Wistar

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  • (PMID = 16157014.001).
  • [ISSN] 0161-6412
  • [Journal-full-title] Neurological research
  • [ISO-abbreviation] Neurol. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / Neurofilament Proteins; 0 / Nitrates; 0 / neurofilament protein L; 114899-12-6 / Clathrin Heavy Chains; EC 3.6.1.- / Chaperonin Containing TCP-1; EC 3.6.1.- / Chaperonins
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31. Stratigos P, Kouskos E, Kouroglou M, Chrisafis I, Fois L, Mavrogiorgis A, Axiotis E, Zamtrakis S: Emergency pancreatoduodenectomy (whipple procedure) for massive upper gastrointestinal bleeding caused by a diffuse B-cell lymphoma of the duodenum: report of a case. Surg Today; 2007;37(8):680-4
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  • [Title] Emergency pancreatoduodenectomy (whipple procedure) for massive upper gastrointestinal bleeding caused by a diffuse B-cell lymphoma of the duodenum: report of a case.
  • We herein report a rare case of a massive upper gastrointestinal (GI) bleeding, caused by high-grade diffuse B-cell lymphoma of the duodenum, secondary to immunoproliferative small intestinal disease (IPSID) and treated with an emergency partial pancreatoduodenectomy.
  • An urgent abdominal ultrasound raised the suspicion of a large, possibly bleeding, neoplasm of the duodenum, which was finally confirmed by abdominal computed tomography.
  • Histologically, the tumor was a high-grade B-cell lymphoma of the duodenum.
  • The nearby small intestinal mucosa was suggestive of IPSID.
  • A massive upper GI hemorrhage from a high-grade B-cell non-Hodgkin lymphoma of the duodenum, which develops secondary to IPSID, is a very rare clinical demonstration of this disease.
  • [MeSH-major] Duodenal Neoplasms / complications. Emergency Treatment. Gastrointestinal Hemorrhage / surgery. Lymphoma, B-Cell / complications. Pancreaticoduodenectomy / methods. Upper Gastrointestinal Tract / surgery
  • [MeSH-minor] Humans. Immunoproliferative Small Intestinal Disease

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  • (PMID = 17643214.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Jiang LF, Yao TM, Zhu ZL, Wang C, Ji LN: Impacts of Cd(II) on the conformation and self-aggregation of Alzheimer's tau fragment corresponding to the third repeat of microtubule-binding domain. Biochim Biophys Acta; 2007 Nov;1774(11):1414-21
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  • Environmental exposure to some heavy metals such as cadmium appears to be a risk factor for Alzheimer's disease (AD), however, definite mechanism of their toxicity in AD remains to be elucidated.
  • Binding to the Cd(II) ion, the dimeric R3 partially lost its random coil, and converted to alpha-helix structure, as revealed by CD and Raman spectrum.
  • On the other hand, gain in alpha-helix structure on the peptide chain, by coordinating with Cd(II), could be a critical role to promote self-aggregation, as revealed by Raman spectrum.
  • [MeSH-major] Alzheimer Disease / metabolism. Cadmium / metabolism. tau Proteins / chemistry. tau Proteins / metabolism


33. Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ: Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation; 2009 Mar 17;119(10):1398-407
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  • BACKGROUND: Cardiac hypertrophy, the clinical hallmark of hypertrophic cardiomyopathy (HCM), is a major determinant of morbidity and mortality not only in HCM but also in a number of cardiovascular diseases.
  • METHODS AND RESULTS: We treated 2-year-old beta-myosin heavy-chain Q403 transgenic rabbits with established cardiac hypertrophy and preserved systolic function with N-acetylcysteine or a placebo for 12 months (n=10 per group).
  • Transgenic rabbits in the placebo group had cardiac hypertrophy, fibrosis, systolic dysfunction, increased oxidized to total glutathione ratio, higher levels of activated thiol-sensitive active protein kinase G, dephosphorylated nuclear factor of activated T cells (NFATc1) and phospho-p38, and reduced levels of glutathiolated cardiac alpha-actin.
  • Treatment with N-acetylcysteine restored oxidized to total glutathione ratio, normalized levels of glutathiolated cardiac alpha-actin, reversed cardiac and myocyte hypertrophy and interstitial fibrosis, reduced the propensity for ventricular arrhythmias, prevented cardiac dysfunction, restored myocardial levels of active protein kinase G, and dephosphorylated NFATc1 and phospho-p38.
  • Because there is no effective pharmacological therapy for HCM and given that hypertrophy, fibrosis, and cardiac dysfunction are common and major predictors of clinical outcomes, the findings could have implications in various cardiovascular disorders.

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  • (PMID = 19255346.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] ENG
  • [Grant] None / None / / R01 HL068884-04; None / None / / P50 HL054313-090012; United States / NHLBI NIH HHS / HL / P50 HL054313; United States / NHLBI NIH HHS / HL / R01 HL068884-02; None / None / / P50 HL054313-060012; United States / NHLBI NIH HHS / HL / R01 HL068884-04; United States / NIAMS NIH HHS / AR / R01 AR056223; United States / NHLBI NIH HHS / HL / R01 HL068884-01; United States / NHLBI NIH HHS / HL / P50 HL054313-080012; None / None / / R01 HL068884-03; United States / NHLBI NIH HHS / HL / R01-HL68884; United States / NHLBI NIH HHS / HL / R01 HL068884-03; United States / NHLBI NIH HHS / HL / R01 HL068884; United States / NHLBI NIH HHS / HL / P50 HL054313-070012; None / None / / P50 HL054313-100012; None / None / / P50 HL054313-08S10012; None / None / / P50 HL054313-080012; United States / NHLBI NIH HHS / HL / P50 HL054313-08S10012; United States / NHLBI NIH HHS / HL / R01 HL068884-05; United States / NHLBI NIH HHS / HL / P50 HL054313-090012; None / None / / R01 HL068884-05; None / None / / P50 HL054313-070012; None / None / / R01 HL068884-02; United States / NHLBI NIH HHS / HL / R01-HL67322; United States / NHLBI NIH HHS / HL / P50 HL054313-100012; United States / NHLBI NIH HHS / HL / R01 HL067322; United States / NHLBI NIH HHS / HL / P50 HL054313-060012; None / None / / R01 HL068884-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antioxidants; 0 / NFATC Transcription Factors; 0 / Sulfhydryl Compounds; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.6.4.1 / Myosin Heavy Chains; GAN16C9B8O / Glutathione; WYQ7N0BPYC / Acetylcysteine
  • [Other-IDs] NLM/ NIHMS113912; NLM/ PMC2773801
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34. Zhu W, Li Y, Liu L, Chen Y, Wang C, Xi F: Supramolecular hydrogels from cisplatin-loaded block copolymer nanoparticles and α-cyclodextrins with a stepwise delivery property. Biomacromolecules; 2010 Nov 8;11(11):3086-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Acrylic Resins / chemistry. Antineoplastic Agents / pharmacology. Cisplatin / pharmacology. Drug Delivery Systems. Hydrogels / chemistry. Polyethylene Glycols / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 20958000.001).
  • [ISSN] 1526-4602
  • [Journal-full-title] Biomacromolecules
  • [ISO-abbreviation] Biomacromolecules
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / Antineoplastic Agents; 0 / Hydrogels; 0 / Macromolecular Substances; 0 / Micelles; 0 / alpha-Cyclodextrins; 30IQX730WE / Polyethylene Glycols; 9003-01-4 / carbopol 940; Q20Q21Q62J / Cisplatin
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35. Ferrer M, Beloqui A, Golyshina OV, Plou FJ, Neef A, Chernikova TN, Fernández-Arrojo L, Ghazi I, Ballesteros A, Elborough K, Timmis KN, Golyshin PN: Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome. Biotechnol J; 2007 Feb;2(2):207-13
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  • A novel enzyme, RA.04, belonging to the alpha-amylase family was obtained after expression of metagenomic DNA from rumen fluid (Ferrer et al.: Environ. Microbiol.
  • The enzyme hydrolyzed alpha-D-(1,4) bonds 13-fold faster than alpha-D-(1,6) bonds to yield maltose and glucose as the main products, and it exhibited transglycosylation activity.
  • Its preferred substrates, in the descending order, were maltooligosaccharides (C3-C7), cyclomaltoheptaose (beta-CD), cyclomaltohexaose (alpha-CD), cyclomaltooctaose (gamma-CD), soluble starch, amylose, pullulan and amylopectin.
  • [MeSH-minor] Amylopectin / metabolism. Amylose / metabolism. Animals. Binding Sites. Catalysis. Cattle. Chromatography, High Pressure Liquid. Electrophoresis, Polyacrylamide Gel. Glucans / metabolism. Hydrogen-Ion Concentration. Maltose / metabolism. Oligosaccharides / metabolism. Starch / metabolism. Substrate Specificity. Temperature. alpha-Cyclodextrins / metabolism. beta-Cyclodextrins / metabolism. gamma-Cyclodextrins / metabolism

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  • (PMID = 17238236.001).
  • [ISSN] 1860-7314
  • [Journal-full-title] Biotechnology journal
  • [ISO-abbreviation] Biotechnol J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Glucans; 0 / Oligosaccharides; 0 / alpha-Cyclodextrins; 0 / beta-Cyclodextrins; 0 / gamma-Cyclodextrins; 0 / maltooligosaccharides; 69-79-4 / Maltose; 8ZQ0AYU1TT / pullulan; 9005-25-8 / Starch; 9005-82-7 / Amylose; 9037-22-3 / Amylopectin; EC 3.2.1.- / Glycoside Hydrolases; EC 3.2.1.54 / cyclomaltodextrinase; JV039JZZ3A / betadex; KZJ0BYZ5VA / gamma-cyclodextrin; Z1LH97KTRM / alpha-cyclodextrin
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36. Zelarayan L, Renger A, Noack C, Zafiriou MP, Gehrke C, van der Nagel R, Dietz R, de Windt L, Bergmann MW: NF-kappaB activation is required for adaptive cardiac hypertrophy. Cardiovasc Res; 2009 Dec 1;84(3):416-24
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  • METHODS AND RESULTS: Cardiac-restricted NF-kappaB inhibition was achieved by expression of a stabilized IkappaBalpha mutant (IkappaBalphaDeltaN) in cells with an active alpha-myosin heavy chain (alphaMHC) promoter employing the Cre/lox technique.
  • [MeSH-minor] Angiotensin II / metabolism. Animals. Apoptosis / physiology. Disease Models, Animal. Female. Fibrosis. I-kappa B Proteins / genetics. I-kappa B Proteins / metabolism. Male. Mice. Mice, Inbred C57BL. Mice, Transgenic. Mutation / genetics. Myocardium / metabolism. Myocardium / pathology. Myocytes, Cardiac / metabolism. Myocytes, Cardiac / pathology. Myosin Heavy Chains / metabolism. Receptor, Angiotensin, Type 1 / physiology. Signal Transduction / physiology

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  • (PMID = 19620128.001).
  • [ISSN] 1755-3245
  • [Journal-full-title] Cardiovascular research
  • [ISO-abbreviation] Cardiovasc. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / I-kappa B Proteins; 0 / NF-kappa B; 0 / Receptor, Angiotensin, Type 1; 11128-99-7 / Angiotensin II; 139874-52-5 / NF-kappaB inhibitor alpha; EC 3.6.4.1 / Myosin Heavy Chains
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37. Danel C, Chaminade P, Odou P, Bartélémy C, Azarzar D, Bonte JP, Vaccher C: Enantioselective analysis of the antipsychotic 9-hydroxyrisperidone, main metabolite of risperidone, by chiral capillary EKC using dual CDs. Electrophoresis; 2007 Aug;28(15):2683-92
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  • Preliminary experiments allowed us to select the more suitable couple of CDs composed of sulfated-alpha-CD and hydroxypropylated-beta-CD.

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  • (PMID = 17600845.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Isoxazoles; 0 / Pyrimidines; 0 / beta-Cyclodextrins; L6UH7ZF8HC / Risperidone; R8P8USM8FR / Paliperidone Palmitate
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38. Al-Saleem T, Al-Mondhiry H: Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. Blood; 2005 Mar 15;105(6):2274-80
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  • [Title] Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms.
  • Immunoproliferative small intestinal disease (IPSID) was recently added to the growing list of infectious pathogen-associated human lymphomas.
  • IPSID is a variant of the B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), which involves mainly the proximal small intestine resulting in malabsorption, diarrhea, and abdominal pain.
  • Geographically, IPSID is most prevalent in the Middle East and Africa.
  • IPSID lymphomas reveal excessive plasma cell differentiation and produce truncated alpha heavy chain proteins lacking the light chains as well as the first constant domain.
  • The corresponding mRNA lacks the variable heavy chain (V(H)) and the constant heavy chain 1 (C(H)1) sequences and contains deletions as well as insertions of unknown origin.
  • Cytogenetic studies demonstrated clonal rearrangements involving predominantly the heavy and light chain genes, including t(9;14) translocation involving the PAX5 gene.
  • Early-stage IPSID responds to antibiotics (30%-70% complete remission).
  • Most untreated IPSID patients progress to lymphoplasmacytic and immunoblastic lymphoma invading the intestinal wall and mesenteric lymph nodes, and may metastasize to a distant organ.
  • IPSID lymphoma shares clinical, morphologic, and molecular features with MALT lymphoma, lymphoplasmacytic lymphoma, and plasma cell neoplasms.
  • [MeSH-major] Campylobacter Infections. Campylobacter jejuni. Immunoproliferative Small Intestinal Disease. Lymphoma, B-Cell, Marginal Zone. Plasma Cells / immunology
  • [MeSH-minor] Adolescent. Adult. Africa. B-Cell-Specific Activator Protein / genetics. B-Cell-Specific Activator Protein / immunology. Child. Chromosomes, Human, Pair 14. Chromosomes, Human, Pair 9 / genetics. Chromosomes, Human, Pair 9 / immunology. Female. Humans. Immunoglobulin Light Chains / genetics. Immunoglobulin Light Chains / immunology. Immunoglobulin Variable Region / genetics. Immunoglobulin Variable Region / immunology. Immunoglobulin alpha-Chains / genetics. Immunoglobulin alpha-Chains / immunology. Intestine, Small / immunology. Intestine, Small / pathology. Lymph Nodes / immunology. Lymph Nodes / pathology. Male. Mesentery / immunology. Mesentery / pathology. Middle East. Sequence Deletion / genetics. Sequence Deletion / immunology. Translocation, Genetic / genetics. Translocation, Genetic / immunology

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  • (PMID = 15542584.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / B-Cell-Specific Activator Protein; 0 / Immunoglobulin Light Chains; 0 / Immunoglobulin Variable Region; 0 / Immunoglobulin alpha-Chains; 0 / PAX5 protein, human
  • [Number-of-references] 78
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39. Figueiredo KM, Marcon RO, Campos IB, Nantes IL, Brochsztain S: Photoinduced electron transfer between cytochrome c and a novel 1,4,5,8-naphthalenetetracarboxylic diimide with amphiphilic character. J Photochem Photobiol B; 2005 Apr 4;79(1):1-9
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  • DNDI formed host-guest complexes with alpha-cyclodextrin (alpha-CD) through the inclusion of the dodecyl group, resulting in an increased aqueous solubility of the compound.

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  • (PMID = 15792874.001).
  • [ISSN] 1011-1344
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / 1,4,5,8-naphthalenetetracarboxylic diimide; 0 / Imides; 0 / Micelles; 0 / Naphthalenes; 0 / Surface-Active Agents; 42VZT0U6YR / Heme; 9007-43-6 / Cytochromes c
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40. Ooya T, Inoue D, Choi HS, Kobayashi Y, Loethen S, Thompson DH, Ko YH, Kim K, Yui N: pH-responsive movement of cucurbit[7]uril in a diblock polypseudorotaxane containing dimethyl beta-cyclodextrin and cucurbit[7]uril. Org Lett; 2006 Jul 20;8(15):3159-62
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  • [Structure: see text] A polypseudorotaxane consisting of cucurbit[7]uril (CB[7])/N,N'-(3-phenylenebis(methylene)dipropargylamine (PMPA), [2]pseudorotaxane, and 2,6-O-dimethyl beta-cyclodextrin (DM-beta-CD)/alpha,omega-bisazidopropylene glycol 400 [2]pseudorotaxane was synthesized using the "click" reaction.

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  • (PMID = 16836355.001).
  • [ISSN] 1523-7060
  • [Journal-full-title] Organic letters
  • [ISO-abbreviation] Org. Lett.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM055266; United States / NIDCR NIH HHS / DE / DE13030
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bridged Compounds; 0 / Cyclodextrins; 0 / Imidazoles; 0 / Rotaxanes; 0 / cucurbit(7)uril
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41. Chen CY, Chen CC, Chung YC: Removal of phthalate esters by alpha-cyclodextrin-linked chitosan bead. Bioresour Technol; 2007 Sep;98(13):2578-83
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  • [Title] Removal of phthalate esters by alpha-cyclodextrin-linked chitosan bead.
  • Removal of phthalate esters (PAEs) by alpha-cyclodextrin (CD)-linked chitosan bead in aqueous solution was studied.
  • DHpP recovery was 94.6% from alpha-CD-linked chitosan bead by shaking both with a mixture of methanol and water (v/v = 8/2).
  • The recovered alpha-CD chitosan bead was reusable as an adsorbent 20 times in the batch tests.
  • The adsorbed PAE by alpha-CD-linked chitosan bead decreased as temperature increased.
  • It was concluded that the application of low cost alpha-CD-linked chitosan bead could have the potential to effectively remove PAEs from different aquatic environments.
  • [MeSH-major] Chitosan / chemistry. Phthalic Acids / isolation & purification. alpha-Cyclodextrins / chemistry

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  • (PMID = 17070038.001).
  • [ISSN] 0960-8524
  • [Journal-full-title] Bioresource technology
  • [ISO-abbreviation] Bioresour. Technol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Esters; 0 / Phthalic Acids; 0 / alpha-Cyclodextrins; 451W47IQ8X / Sodium Chloride; 9012-76-4 / Chitosan; SY7Q814VUP / Calcium; Z1LH97KTRM / alpha-cyclodextrin
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42. Taira T, Suzaki Y, Osakada K: Hydrogels composed of organic amphiphiles and alpha-cyclodextrin: supramolecular networks of their pseudorotaxanes in aqueous media. Chemistry; 2010 Jun 11;16(22):6518-29
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  • [Title] Hydrogels composed of organic amphiphiles and alpha-cyclodextrin: supramolecular networks of their pseudorotaxanes in aqueous media.
  • Mixtures of N-alkyl pyridinium compounds [py-N-(CH(2))(n)OC(6)H(3)-3,5-(OMe)(2)](+)(X(-)) (1bCl: n = 10, X = Cl; 1cBr: n = 12, X = Br) and alpha-cyclodextrin (alpha-CD) form supramolecular hydrogels in aqueous media.
  • Washing the hydrogel with acetone or evaporation of water left the xerogel, and (13)C CP/MAS NMR measurements, powder X-ray diffraction (XRD), and scanning electron microscopy (SEM) revealed that the xerogel of 1bCl (or 1cBr) and alpha-CD was composed of pseudorotaxanes with high crystallinity. (13)C{(1)H} and (1)H NMR spectra of the gel revealed the detailed composition of the components.
  • The gel from 1bCl and alpha-CD contains the corresponding [2]- and [3]pseudorotaxanes, [1b x (alpha-CD)]Br and [1b x (alpha-CD)(2)]Br, while that from 1cBr and alpha-CD consists mainly of [3]pseudorotaxane [1c x (alpha-CD)(2)]Br.
  • Thus, intermolecular interaction between the end groups of the axle component and that between alpha-CDs of the [3]pseudorotaxane contribute to formation of the network.
  • The supramolecular gels were transformed into sols by adding denaturing agents such as urea, C(6)H(3)-1,3,5-(OH)(3), and [py-N-nBu](+)(Cl(-)).

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  • (PMID = 20411534.001).
  • [ISSN] 1521-3765
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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43. Fu GD, Xu LQ, Yao F, Li GL, Kang ET: Smart nanofibers with a photoresponsive surface for controlled release. ACS Appl Mater Interfaces; 2009 Nov;1(11):2424-7
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  • A novel photocontrolled "ON-OFF" release system for the alpha-cyclodextrin-5-fluorouracial (alpha-CD-5FU) prodrug, based on host-guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated.
  • [MeSH-major] Light. Nanofibers / chemistry. alpha-Cyclodextrins / pharmacology

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  • (PMID = 20356110.001).
  • [ISSN] 1944-8244
  • [Journal-full-title] ACS applied materials & interfaces
  • [ISO-abbreviation] ACS Appl Mater Interfaces
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cross-Linking Reagents; 0 / Delayed-Action Preparations; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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44. Lowey S, Lesko LM, Rovner AS, Hodges AR, White SL, Low RB, Rincon M, Gulick J, Robbins J: Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone. J Biol Chem; 2008 Jul 18;283(29):20579-89
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  • [Title] Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone.
  • The R403Q mutation in the beta-myosin heavy chain (MHC) was the first mutation to be linked to familial hypertrophic cardiomyopathy (FHC), a primary disease of heart muscle.
  • The introduction of the mouse model for FHC (the mouse expresses predominantly alpha-MHC as opposed to the beta-isoform in larger mammals) created a new paradigm for FHC based on finding enhanced motor function for R403Q alpha-MHC.
  • To help resolve these conflicting mechanisms, we used a transgenic mouse model in which the endogenous alpha-MHC was largely replaced with transgenically encoded beta-MHC.
  • A His(6) tag was cloned at the N terminus of the alpha-and beta-MHC to facilitate protein isolation by Ni(2+)-chelating chromatography.
  • Characterization of the R403Q alpha-MHC by the in vitro motility assay showed a 30-40% increase in actin filament velocity compared with wild type, consistent with published studies.
  • We find that the actin-activated MgATPase activity for R403Q alpha-S1 is approximately 30% higher than for wild type, whereas the enzymatic activity for R403Q beta-S1 is reduced by approximately 10%.

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  • (PMID = 18480046.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL 087862; United States / NHLBI NIH HHS / HL / HL 077101; United States / NHLBI NIH HHS / HL / HL 074728; United States / NHLBI NIH HHS / HL / HL 69799; United States / NCRR NIH HHS / RR / P20 RR 16435; United States / NHLBI NIH HHS / HL / HL 59408; United States / NIAMS NIH HHS / AR / AR 053975
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Protein Isoforms; 721M9407IY / Propylthiouracil; 94ZLA3W45F / Arginine; EC 3.6.1.- / Ca(2+) Mg(2+)-ATPase; EC 3.6.1.- / Ventricular Myosins; EC 3.6.4.1 / Myosin Heavy Chains
  • [Other-IDs] NLM/ PMC2459289
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45. Trapani A, Lopedota A, Franco M, Cioffi N, Ieva E, Garcia-Fuentes M, Alonso MJ: A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides. Eur J Pharm Biopharm; 2010 May;75(1):26-32
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  • [Title] A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides.
  • More precisely, NP formulations composed of CS, CS/alpha-CD and CS/sulphobutyl ether-beta-cyclodextrin (SBE(7m)-beta-CD) were investigated for this application.
  • Transport studies performed in the frog intestine model confirmed that both CS and CS/CD nanoparticles could induce permeabilization of the intestinal epithelia.
  • From the data obtained, we believe that CS/CD nanoparticles might represent an interesting technological platform for the oral administration of small peptides.
  • [MeSH-minor] Administration, Oral. Animals. Chitosan. Intestinal Absorption / drug effects. Intestinal Absorption / physiology. Rana esculenta

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  • (PMID = 20102738.001).
  • [ISSN] 1873-3441
  • [Journal-full-title] European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
  • [ISO-abbreviation] Eur J Pharm Biopharm
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Drug Carriers; 0 / Peptide Fragments; 9012-76-4 / Chitosan; GAN16C9B8O / Glutathione
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46. Plazanet M, Dean M, Merlini M, Hüller A, Emerich H, Meneghini C, Johnson MR, Trommsdorff HP: Crystallization on heating and complex phase behavior of alpha-cyclodextrin solutions. J Chem Phys; 2006 Oct 21;125(15):154504
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  • [Title] Crystallization on heating and complex phase behavior of alpha-cyclodextrin solutions.
  • Solutions composed of alpha-cyclodextrin (alpha-CD), water, and various methylpyridines, in particular, 4-methylpyridine (4MP), undergo reversible liquid-solid transitions upon heating, the crystalline solid phases undergoing further phase transformations at higher temperatures.
  • For the alpha-CD/4MP system five crystalline phases have been identified.
  • A simple model is proposed that mimics the observed disorder-order transition.

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  • (PMID = 17059269.001).
  • [ISSN] 0021-9606
  • [Journal-full-title] The Journal of chemical physics
  • [ISO-abbreviation] J Chem Phys
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Oh HJ, Lee H, Park JW, Rhee H, Koo SK, Kang S, Jo I, Jung SC: Reversal of gene expression profile in the phenylketonuria mouse model after adeno-associated virus vector-mediated gene therapy. Mol Genet Metab; 2005 Dec;86 Suppl 1:S124-32
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  • Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by phenylalanine hydroxylase (PAH) deficiency.
  • Four are involved in defense and inflammatory responses of neutrophils (NE, MPO, NGP, and CRAMP), three other overexpressed genes are related to extracellular matrix organization and degradation (COL1A1, COL1A2, and MMP13); the remainder were a nociceptor in sensory neurons (MrgA1), a structural gene of P lysozyme (Lzp-s), an immunoglobulin alpha heavy chain constant region gene (Igh-2), an osteocalcin-related protein precursor (Bglap-rs1), and a membrane-spanning 4 domain, subfamily A, member 3 (Ms4a3).
  • [MeSH-minor] Animals. Dependovirus / genetics. Disease Models, Animal. Gene Transfer Techniques. Genetic Vectors. Mice. Mice, Mutant Strains. Oligonucleotide Array Sequence Analysis. Phenylalanine Hydroxylase / deficiency. Phenylalanine Hydroxylase / genetics. Transgenes. Up-Regulation


48. Taira T, Suzaki Y, Osakada K: Thermosensitive hydrogels composed of cyclodextrin pseudorotaxanes. Role of [3]pseudorotaxane in the gel formation. Chem Commun (Camb); 2009 Dec 7;(45):7027-9
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  • Pseudorotaxanes composed of an alkylpyridinium and alpha-cyclodextrin (alpha-CD) form supramolecular hydrogels which show sol-gel transitions at 7-67 degrees C depending on the type and amount of the guest compound.

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  • (PMID = 19904383.001).
  • [ISSN] 1364-548X
  • [Journal-full-title] Chemical communications (Cambridge, England)
  • [ISO-abbreviation] Chem. Commun. (Camb.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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49. Stirn Kranjc B, Smerdu V, Erzen I: Histochemical and immunohistochemical profile of human and rat ocular medial rectus muscles. Graefes Arch Clin Exp Ophthalmol; 2009 Nov;247(11):1505-15
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  • To reveal myosin heavy chain (MyHC) isoforms, specific monoclonal antibodies against MyHC-1/beta- slow, alpha-cardiac (-alpha), -2a, -2x, -2b, -extraocular (eom), -embryonic (-emb) and -neonatal (-neo) were applied.
  • In the orbital layer most fibers were highly oxidative and expressed fast MyHC isoforms, whereas slow and oxidative fibers expressed MyHC-1 and -alpha, some of them also MyHC-2a, -2x, -eom, very rarely -emb, and -neo.
  • The slow medium-sized fibers with mATPase activity stable at pH 4.4 expressed mostly MyHC-1 and -alpha in rat, while in humans they co-expressed MyHC-1 with -2b, -2x, -eom, and -neo.
  • In both species, the fast fibers showed variable mATPase activity after preincubation at pH 9.4, and co-expressed various combinations of MyHC-2b, -2x, -2a and -eom but not -emb and -neo.
  • CONCLUSIONS: Rat MR represent a good model that can be applied to study human MR in experiment or disease, however certain differences are to be expected due to specific oculomotor demands in humans.
  • [MeSH-minor] Adenosine Triphosphatases / metabolism. Adult. Animals. Female. Glycerol-3-Phosphate Dehydrogenase (NAD+) / metabolism. Humans. Immunoenzyme Techniques. In Situ Hybridization. Male. Middle Aged. Models, Biological. Myosin Heavy Chains / metabolism. Protein Isoforms / metabolism. Rats. Rats, Wistar. Succinate Dehydrogenase / metabolism. Young Adult

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  • (PMID = 19609551.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Protein Isoforms; EC 1.1.1.8 / Glycerol-3-Phosphate Dehydrogenase (NAD+); EC 1.3.99.1 / Succinate Dehydrogenase; EC 3.6.1.- / Adenosine Triphosphatases; EC 3.6.4.1 / Myosin Heavy Chains
  • [Other-IDs] NLM/ PMC2758108
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50. Yu Y, Cai W, Chipot C, Sun T, Shao X: Spatial arrangement of alpha-cyclodextrins in a rotaxane. Insights from free-energy calculations. J Phys Chem B; 2008 May 1;112(17):5268-71
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  • [Title] Spatial arrangement of alpha-cyclodextrins in a rotaxane. Insights from free-energy calculations.
  • The rotaxane formed by alpha-cyclodextrins (alpha-CDs) threaded onto a poly(ethylene glycol) (PEG) chain was investigated in the gas phase and in an aqueous solution by means of molecular dynamics simulations.
  • The free-energy difference between the three possible spatial arrangements of consecutive alpha-CD--viz.. head-to-head (HH), head-to-tail (HT), and tail-to-tail, was determined using free-energy perturbation calculations.
  • These simulations reveal that the interaction of alpha-CD with the PEG chain is very similar in the two surroundings, whereas the mutual interaction of the macrocycles is stronger in the gas phase than in the aqueous solution.
  • Analysis of intermolecular hydrogen bonds indicates that hydrogen bonds created between alpha-CD and water molecules weaken the hydrogen-bonding interaction of adjacent alpha-CDs.
  • Comparison of the free-energy differences characteristic of the three possible spatial arrangements of contiguous alpha-CDs reveals that the HH motif of the rotaxane is the most stable in the gas phase due to the hydrogen-bond formation between the secondary hydroxyl groups of the two alpha-CDs, and the slight preference for the HT motif in aqueous solution, which can be related to the directionality of the dipole moment borne by the macrocycles in these two motifs.

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  • (PMID = 18393550.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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51. Masaki M, Izumi M, Oshima Y, Nakaoka Y, Kuroda T, Kimura R, Sugiyama S, Terai K, Kitakaze M, Yamauchi-Takihara K, Kawase I, Hirota H: Smad1 protects cardiomyocytes from ischemia-reperfusion injury. Circulation; 2005 May 31;111(21):2752-9
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  • To examine physiological and pathological roles of Smad1 in I/R, we generated Smad1TG using the alpha-myosin heavy chain gene promoter.
  • To examine whether Smad1 prevents injury of cardiomyocytes in vivo, we subjected Smad1TG and age-matched wild-type mice (WT) to I/R injury induced by 1 hour of ligation of the left coronary artery and 1 hour of reperfusion.
  • [MeSH-minor] Animals. Animals, Newborn. Apoptosis. Cell Survival / drug effects. Cells, Cultured. Disease Models, Animal. Humans. Mice. Mice, Transgenic. Myocardial Infarction / pathology. Myocardial Infarction / prevention & control. Phosphorylation. Rats. Rats, Wistar. Signal Transduction. Transfection

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  • (PMID = 15911698.001).
  • [ISSN] 1524-4539
  • [Journal-full-title] Circulation
  • [ISO-abbreviation] Circulation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Smad1 Protein; 0 / Smad1 protein, mouse
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52. Ishikawa S, Hirota S, Neya S, Funasaki N: Molecular motions of alpha-cyclodextrin on a dodecyl chain studied by molecular dynamics simulations. Chem Pharm Bull (Tokyo); 2006 Apr;54(4):528-34
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  • [Title] Molecular motions of alpha-cyclodextrin on a dodecyl chain studied by molecular dynamics simulations.
  • Motions of an alpha-cyclodextrin (alpha-CD) molecule on a dodecyl chain adopting the all-trans conformation were investigated in the presence of water by molecular dynamics simulations with CVFF force fields, where the trimethylammonium group of dodecyltrimethylammonium bromide (DTAB) is protruded outside the secondary hydroxyl rim of alpha-CD (the secondary-in structure).
  • The alpha-CD molecule shuttled rapidly on the chain without decomplexation.
  • The plane formed by 6 O4 atoms of alpha-CD is most populated between the C6 and C7 atoms of DTAB.
  • The alpha-CD molecule underwent a restricted rotation in a range of 60 degrees with regard to the plane of the dodecyl chain: this plane at the most population is middle between the two diagonal lines of the normal hexagon formed by 6 O4 atoms of alpha-CD.
  • The distortion of the alpha-CD cavity from the normal hexagon was decreased upon complex formation with DTAB.
  • The deviation of the center of alpha-CD from the center of the dodecyl chain predicted by molecular dynamics simulations is consistent with the NMR data.
  • [MeSH-major] Computer Simulation. Models, Molecular. Quaternary Ammonium Compounds / chemistry. Surface-Active Agents / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 16595958.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Quaternary Ammonium Compounds; 0 / Surface-Active Agents; 0 / alpha-Cyclodextrins; 10182-91-9 / dodecyltrimethylammonium; Z1LH97KTRM / alpha-cyclodextrin
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53. Miyauchi M, Takashima Y, Yamaguchi H, Harada A: Chiral supramolecular polymers formed by host-guest interactions. J Am Chem Soc; 2005 Mar 9;127(9):2984-9
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  • alpha-Cyclodextrin with a p-t-butoxyaminocinnamoylamino group in the 3-position (3-p-(t)()BocCiNH-alpha-CD) has been found to form a supramolecular polymer in an aqueous solution.

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  • (PMID = 15740135.001).
  • [ISSN] 0002-7863
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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54. Shi RQ, Lee JK, Hayashi Y, Takeuchi Y, Kambe F, Futaki S, Seo H, Murata Y, Kodama I: Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile. Eur J Pharmacol; 2008 Jan 14;578(2-3):270-8
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  • Northern blots of left ventricular myocardium showed a parallel decrease in mRNAs for myosin heavy chain (MHC)-alpha and a parallel increase for myosin heavy chain (MHC)-beta in hypothyroidism and amiodarone.
  • [MeSH-minor] Animals. Blotting, Northern. Cluster Analysis. Disease Models, Animal. Electrocardiography. Heart Conduction System / drug effects. Heart Rate / drug effects. Heart Ventricles / drug effects. Heart Ventricles / metabolism. Liver / drug effects. Liver / metabolism. Male. Methimazole. Oligonucleotide Array Sequence Analysis. Pituitary Gland / drug effects. Pituitary Gland / metabolism. RNA, Messenger / metabolism. Rats. Rats, Wistar. Time Factors

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  • (PMID = 17991464.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Arrhythmia Agents; 0 / RNA, Messenger; 554Z48XN5E / Methimazole; N3RQ532IUT / Amiodarone
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55. Wellner M, Dechend R, Park JK, Shagdarsuren E, Al-Saadi N, Kirsch T, Gratze P, Schneider W, Meiners S, Fiebeler A, Haller H, Luft FC, Muller DN: Cardiac gene expression profile in rats with terminal heart failure and cachexia. Physiol Genomics; 2005 Feb 10;20(3):256-67
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  • THF-dTGR and dTGR showed upregulation of hypertrophy markers and alpha/beta-myosin heavy chain switch to the fetal isoform.
  • Various genes of mitochodrial respiratory chain and lipid catabolism were reduced.
  • [MeSH-minor] Animals. Databases, Nucleic Acid. Disease Models, Animal. Echocardiography. Male. Rats. Rats, Sprague-Dawley


56. Yamauchi K, Takashima Y, Hashidzume A, Yamaguchi H, Harada A: Switching between supramolecular dimer and nonthreaded supramolecular self-assembly of stilbene amide-alpha-cyclodextrin by photoirradiation. J Am Chem Soc; 2008 Apr 16;130(15):5024-5
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  • [Title] Switching between supramolecular dimer and nonthreaded supramolecular self-assembly of stilbene amide-alpha-cyclodextrin by photoirradiation.
  • 3-trans-Stilbene amide-alpha-cyclodextrin (3-trans-Sti-alpha-CD) formed a double-threaded dimer in aqueous solutions.
  • In contrast, the photoisomerization of the stilbene moiety in 3-Sti-alpha-CD from trans to cis leads to the structural changes from the double-threaded dimer to nonthreaded supramolecular assemblies in aqueous solutions.
  • [MeSH-major] Amides / chemistry. Stilbenes / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 18335989.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amides; 0 / Stilbenes; 0 / alpha-Cyclodextrins; Z1LH97KTRM / alpha-cyclodextrin
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57. Travelet C, Schlatter G, Hébraud P, Brochon C, Lapp A, Hadziioannou G: Formation and self-organization kinetics of alpha-CD/PEO-based pseudo-polyrotaxanes in water. A specific behavior at 30 degrees C. Langmuir; 2009 Aug 4;25(15):8723-34
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  • [Title] Formation and self-organization kinetics of alpha-CD/PEO-based pseudo-polyrotaxanes in water. A specific behavior at 30 degrees C.
  • alpha-Cyclodextrins (alpha-CDs) have the ability to form inclusion complexes with poly(ethylene oxide) (PEO) polymer chains.
  • These pseudo-polyrotaxanes (PPRs) can be obtained by quenching an alpha-CD/PEO mixture in water from 70 degrees C down to a lower temperature (typically in the range from 5 to 30 degrees C) thanks to favorable interactions between alpha-CD cavities and PEO chains.
  • Moreover, starting from a liquid alpha-CD/PEO mixture at a total mass fraction of 15% w/w at 70 degrees C, the formation of PPRs with time at a lower temperature induces a white physical gel with time, and phase separation is observed.
  • We established that PPR molecules are exclusively found in the precipitated phase although unthreaded alpha-CD molecules and unthreaded PEO chains are in the liquid phase.
  • At 30 degrees C, we established that, in a first step, alpha-CDs thread onto PEO chains, forming PPR molecules which are not in good solvent conditions in water.
  • At a higher length scale, rapid aggregation of the PPR molecules occurs, and threaded alpha-CD-based nanocylinders form (cylinder length L = 5.7 nm and cylinder radius R = 4.7 nm).
  • At a higher length scale, alpha-CD-based nanocylinders associate in a Gaussian way, engendering the formation of precipitated domains which are responsible for the high turbidity of the studied system.
  • [MeSH-major] Taxoids / chemical synthesis. Taxoids / chemistry. Water / chemistry. alpha-Cyclodextrins / chemistry

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  • (PMID = 19301842.001).
  • [ISSN] 1520-5827
  • [Journal-full-title] Langmuir : the ACS journal of surfaces and colloids
  • [ISO-abbreviation] Langmuir
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Polymers; 0 / Taxoids; 0 / alpha-Cyclodextrins; 059QF0KO0R / Water; 30IQX730WE / Polyethylene Glycols; Z1LH97KTRM / alpha-cyclodextrin
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58. Lecuit M, Lortholary O: [Immunoproliferative small intestinal disease associated with Campylobacter jejuni]. Med Mal Infect; 2005 Jun;35 Suppl 2:S56-8
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  • [Title] [Immunoproliferative small intestinal disease associated with Campylobacter jejuni].
  • [Transliterated title] Maladie immunoproliférative de l'intestin grêle associée à Campylobacter jejuni.
  • [MeSH-major] Campylobacter Infections / complications. Intestinal Diseases / microbiology. Lymphoma, B-Cell, Marginal Zone / microbiology

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  • (PMID = 15978389.001).
  • [ISSN] 0399-077X
  • [Journal-full-title] Médecine et maladies infectieuses
  • [ISO-abbreviation] Med Mal Infect
  • [Language] fre
  • [Publication-type] Journal Article
  • [Publication-country] France
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59. Hernández-Pascacio J, Garza C, Banquy X, Díaz-Vergara N, Amigo A, Ramos S, Castillo R, Costas M, Piñeiro A: Cyclodextrin-based self-assembled nanotubes at the water/air interface. J Phys Chem B; 2007 Nov 8;111(44):12625-30
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  • Native alpha-cyclodextrin (alpha-CD) is found to spontaneously form films at aqueous solution/air interfaces.
  • By using isothermal titration calorimetry (ITC), Brewster angle microscopy (BAM), atomic force microscopy (AFM), and molecular dynamics (MD) simulations, it is shown that the films consist of self-assembled nanotubes whose building blocks are cyclodextrin dimers (alpha-CD2) and alpha-CD2-SDS1 complexes.

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  • (PMID = 17941668.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Solutions; 059QF0KO0R / Water; 368GB5141J / Sodium Dodecyl Sulfate
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60. Wirz W, Antoine M, Tag CG, Gressner AM, Korff T, Hellerbrand C, Kiefer P: Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells. Differentiation; 2008 Sep;76(7):784-94
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  • Hepatic stellate cells (HSCs) are pericytes of liver sinusoidal endothelial cells (LSECs) and activation of HSC into a myofibroblast-like phenotype (called transdifferentiation) is involved in several hepatic disease processes including neovascularization during liver metastasis, chronic and acute liver injury.
  • While early smooth muscle cell (SMC) differentiation markers including SM alpha-actin and SM22alpha are expressed in a variety of non-SMC, expression of late-stage markers is far more restricted.
  • Here, we found that in addition to early SMC markers, activated rat HSC express a large panel of characteristic late vascular SMC markers including SM myosin heavy chain, h1-calponin and h-caldesmon.

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  • (PMID = 18177423.001).
  • [ISSN] 1432-0436
  • [Journal-full-title] Differentiation; research in biological diversity
  • [ISO-abbreviation] Differentiation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Recombinant Proteins; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A
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61. Lammers I, Buijs J, Ariese F, Gooijer C: Sensitized enantioselective laser-induced phosphorescence detection in chiral capillary electrophoresis. Anal Chem; 2010 Nov 15;82(22):9410-7
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  • Excitation was performed at 266 nm with a pulsed, small-sized, quadrupled Nd:YAG laser.

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  • (PMID = 20964317.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Resins, Synthetic; 76-22-2 / Camphor; RAL3591W33 / camphorquinone
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62. Jiang X, Ren YP, Lv ZR: Ouabain induces cardiac remodeling in rats independent of blood pressure. Acta Pharmacol Sin; 2007 Mar;28(3):344-52
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  • After 4 and 6 weeks, echocardiography were performed, hemodynamic parameters were measured by invasive cardiac catheterization, changes in cardiac ultrastructure were analyzed using transmission electron microscopy, the collagen fraction of the left ventricle was assessed with Picrosirius red stain, and RT-PCR was applied to evaluate the mRNA level of myosin heavy chain-alpha and -beta in the left ventricle.
  • Moreover, the cardiac MHC-beta mRNA was upregulated by ouabain treatment, whereas MHC-alpha mRNA was downregulated.
  • [MeSH-minor] Animals. Echocardiography. Glyceraldehyde-3-Phosphate Dehydrogenases / biosynthesis. Glyceraldehyde-3-Phosphate Dehydrogenases / genetics. Male. Myosin Heavy Chains / biosynthesis. Myosin Heavy Chains / genetics. Rats. Rats, Sprague-Dawley. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17302996.001).
  • [ISSN] 1671-4083
  • [Journal-full-title] Acta pharmacologica Sinica
  • [ISO-abbreviation] Acta Pharmacol. Sin.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Cardiotonic Agents; 5ACL011P69 / Ouabain; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases; EC 3.6.4.1 / Myosin Heavy Chains
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63. Shaikh M, Mohanty J, Bhasikuttan AC, Pal H: Tuning dual emission behavior of p-dialkylaminobenzonitriles by supramolecular interactions with cyclodextrin hosts. Photochem Photobiol Sci; 2008 Aug;7(8):979-85
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  • Ground state absorption and steady-state and time-resolved fluorescence measurements have been carried out to understand the host-guest interactions of p-diethylaminobenzonitrile (DEABN) and p-dimethylaminobenzonitrile (DMABN) dyes with alpha-cyclodextrin (alpha-CD) and beta-cyclodextrin (beta-CD) hosts.
  • DEABN and DMABN dyes show both locally excited (LE) state and intramolecular charge transfer (ICT) state emissions in solution.
  • The LE and ICT emissions of the dyes are seen to get modulated in the presence of alpha-CD and beta-CD hosts.
  • The results indicate that the dyes form 1 : 1 inclusion complexes with both the hosts.
  • Comparing the binding constants and the fluorescence characteristics of different dye x CD systems it is inferred that DEABN adopts a completely different orientation on complexation with alpha-CD than in the other cases of dye.CD systems.
  • It is indicated that while in all other cases of dye x CD systems the N,N-dialkyl group of the dyes enters the host cavity leaving the C[triple bond, length as m-dash]N group projected out into the water phase, the DEABN dye enters the alpha-CD cavity (smallest CD) with its C[triple bond, length as m-dash]N group entering the host cavity.
  • The differences in the orientation of the dye in the host cavities is understood to be determined by the requirement of maximum van der Waals contact of the encapsulated dye with the host cavity for maximum stability of the complex and the relative sizes of the substituents of the dye compared to the host cavities.

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  • (PMID = 18688506.001).
  • [ISSN] 1474-905X
  • [Journal-full-title] Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • [ISO-abbreviation] Photochem. Photobiol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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64. Babetto E, Mangolini A, Rizzardini M, Lupi M, Conforti L, Rusmini P, Poletti A, Cantoni L: Tetracycline-regulated gene expression in the NSC-34-tTA cell line for investigation of motor neuron diseases. Brain Res Mol Brain Res; 2005 Oct 31;140(1-2):63-72
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  • [Title] Tetracycline-regulated gene expression in the NSC-34-tTA cell line for investigation of motor neuron diseases.
  • Alpha-tubulin, GAP-43 and phosphorylated medium and heavy neurofilaments, proteins of importance for the motor neuronal phenotype, were evident in NSC-34-tTA40 by Western blot and immunocytochemistry; they were expressed similarly in NSC-34-tTA40 and in NSC-34.
  • [MeSH-major] Gene Expression Regulation / drug effects. Motor Neuron Disease / genetics. Tetracycline / pharmacology
  • [MeSH-minor] Animals. Base Sequence. Cell Line. DNA Primers. Genes, Reporter. Green Fluorescent Proteins / genetics. Humans. Mice. Mice, Transgenic. Motor Neurons. Reverse Transcriptase Polymerase Chain Reaction. Superoxide Dismutase / genetics. Transfection

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  • (PMID = 16125275.001).
  • [ISSN] 0169-328X
  • [Journal-full-title] Brain research. Molecular brain research
  • [ISO-abbreviation] Brain Res. Mol. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Primers; 147336-22-9 / Green Fluorescent Proteins; EC 1.15.1.- / superoxide dismutase 1; EC 1.15.1.1 / Superoxide Dismutase; F8VB5M810T / Tetracycline
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65. Song J, Patel M, Rosenzweig CN, Chan-Li Y, Sokoll LJ, Fung ET, Choi-Miura NH, Goggins M, Chan DW, Zhang Z: Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay. Clin Chem; 2006 Jun;52(6):1045-53
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  • [Title] Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption/ionization-based immunoassay.
  • BACKGROUND: Several proteolytically derived fragments from the proline-rich region (PRR) of human inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) have been identified by surface-enhanced or matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS or MALDI-TOF-MS) as potential disease markers.
  • In this study, we used this high-throughput approach to quantify and characterize the extensive fragmentation within the PRR of human serum ITIH4 and determined its association with different disease conditions.
  • RESULTS: Human serum ITIH4 was shown to be extensively proteolytically processed within the PRR, and its fragmentation patterns were closely associated with different disease conditions.
  • CONCLUSIONS: The fragmentation patterns within the PRR of human serum ITIH4 are associated with different disease conditions and may hold important diagnostic information.

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  • (PMID = 16574760.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1P50 CA83639; United States / NCI NIH HHS / CA / CA115102-01; United States / NCI NIH HHS / CA / CA62924
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Blood Proteins; 0 / Glycoproteins; 0 / ITIH4 protein, human; 0 / Proteinase Inhibitory Proteins, Secretory
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66. Parfenov AI, Krums LM, Sivash ES, Tsaregorodtseva TM, Poleva NI, Ruchkina IN, Sabel'nikova EA, Chikunova BZ: [Algorithm for diagnosis of small intestinal diseases]. Ter Arkh; 2008;80(4):46-51
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  • [Title] [Algorithm for diagnosis of small intestinal diseases].
  • AIM: To review diagnostic approaches in chronic diseases of the small intestine.
  • MATERIAL AND METHODS: A total of 1096 patients with chronic diseases of the small intestine were admitted to the clinic of the Central Research Institute of Gastroenterological Diseases in 1987-2006.
  • RESULTS: Most of the patients (90.5%) had celiac disease, hypolactasia and other types of disaccharidase deficiency, yersiniosis ileitis, Krohn's disease, postresection syndrome of a short small intestine, mesenterial ischemia and endocrine enteropathy.
  • Rare diseases (general variable hypogammaglobulinemia, lymphoma, Wipple's disease and diverticulosis of the small intestine) were diagnosed in 5.8% cases.
  • Primary amyloidosis of the small intestine, eosinophilic gastroenteritis, arteriomesenterial obstruction, primary intestinal pseudoobstruction, hypogammaglobulinemic spru, primary intestinal lymphangiectasia, tuberculosis, total polyposis, Peutz-Eggers and Cronkhite-Canada syndromes, collagenic sprue, erosive-ulcerative jejunoileitis, adenocarcinoma and heavy alpha-chain disease were detected in 3.7% examinees.
  • These diseases were encountered in one to 5 cases for the latest 20 years.
  • CONCLUSION: Clinical diagnosis of small intestinal diseases is based on the syndromes of chronic diarrhea, defective absorption, enteral protein loss, small intestinal obstruction and intestinal hemorrhage.
  • Differential diagnosis of the nosological entities employs x-ray, endoscopic, histological, immunological and other methods.
  • Most of the small intestinal diseases including rare can be diagnosed in any gastroentorological department.
  • [MeSH-major] Algorithms. Endoscopy, Gastrointestinal / methods. Immunologic Tests / methods. Intestinal Diseases / diagnosis. Intestine, Small. Radiography, Abdominal / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18491580.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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67. Hifumi E, Higashi K, Uda T: Catalytic digestion of human tumor necrosis factor-α by antibody heavy chain. FEBS J; 2010 Sep;277(18):3823-32
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  • [Title] Catalytic digestion of human tumor necrosis factor-α by antibody heavy chain.
  • Tumor necrosis factor-α (TNF-α) is a cytokine and an important molecule concerned with autoimmune diseases such as rheumatoid arthritis, chronic obstructive pulmonary disease, and Crohn's disease.
  • The heavy chain (ETNF-6-H) of the mAb was considered to possess a catalytic triad-like structure in the complementarity determining regions (CDRs).
  • The heavy chain possessed a protease activity against TNF-α with a multicleavage site.
  • [MeSH-major] Antibodies, Catalytic / metabolism. Antibodies, Monoclonal / immunology. Antibodies, Monoclonal / metabolism. Immunoglobulin Heavy Chains / metabolism. Tumor Necrosis Factor-alpha / immunology. Tumor Necrosis Factor-alpha / metabolism

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  • [Copyright] © 2010 The Authors Journal compilation © 2010 FEBS.
  • (PMID = 20718866.001).
  • [ISSN] 1742-4658
  • [Journal-full-title] The FEBS journal
  • [ISO-abbreviation] FEBS J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Catalytic; 0 / Antibodies, Monoclonal; 0 / Immunoglobulin Heavy Chains; 0 / Peptides; 0 / Tumor Necrosis Factor-alpha
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68. Villaverde J, Maqueda C, Undabeytia T, Morillo E: Effect of various cyclodextrins on photodegradation of a hydrophobic herbicide in aqueous suspensions of different soil colloidal components. Chemosphere; 2007 Sep;69(4):575-84
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  • The irradiation of NFL aqueous solutions in the presence of CDs showed that the higher the formation constant of NFL-CD complexes (Kc) and their solubility, the higher their photocatalytic effects, following the CDs in the order: RAMEB>HPBCD>beta-CD>alpha-CD>gamma-CD.

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  • (PMID = 17462707.001).
  • [ISSN] 0045-6535
  • [Journal-full-title] Chemosphere
  • [ISO-abbreviation] Chemosphere
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Colloids; 0 / Cyclodextrins; 0 / Environmental Pollutants; 0 / Herbicides; 0 / Pyridazines; 0 / Soil; 0 / Solutions; KES1HB07E4 / norflurazone
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69. Haddad F, Qin AX, Bodell PW, Jiang W, Giger JM, Baldwin KM: Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes. Am J Physiol Heart Circ Physiol; 2008 Jan;294(1):H29-40
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  • [Title] Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes.
  • Cardiac myosin heavy chain (MHC) gene expression undergoes a rapid transition from beta- to alpha-MHC during early rodent neonatal development (0-21 days of age).
  • We analyzed the expression of alpha- and beta-MHC at protein, mRNA, and pre-mRNA levels at birth and 7, 10, 15, and 21 days after birth in euthyroid and hypothyroid rodents.
  • On the second half of the IG region, sense transcription occurs, resulting in expression of a sense IG RNA that merges with the alpha-MHC pre-mRNA.
  • This sense IG RNA transcription was detected in the alpha-MHC gene promoter, approximately -1.8 kb relative to the alpha-MHC transcription start site.
  • [MeSH-major] DNA, Intergenic. Gene Expression Regulation, Developmental. Hypothyroidism / genetics. Myocardium / metabolism. Myosin Heavy Chains / genetics. Transcription, Genetic. Ventricular Myosins / genetics
  • [MeSH-minor] Aging. Animals. Animals, Newborn. Base Sequence. Body Weight. Disease Models, Animal. Epigenesis, Genetic. Gene Transfer Techniques. Genes, Reporter. Heart Ventricles / growth & development. Heart Ventricles / metabolism. Molecular Sequence Data. Promoter Regions, Genetic. Propylthiouracil. RNA, Antisense / metabolism. RNA, Messenger / metabolism. Rats. Reverse Transcriptase Polymerase Chain Reaction. Time Factors. Transcription Initiation Site. Triiodothyronine / blood

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  • [CommentIn] Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H14-5 [17993592.001]
  • (PMID = 17982008.001).
  • [ISSN] 0363-6135
  • [Journal-full-title] American journal of physiology. Heart and circulatory physiology
  • [ISO-abbreviation] Am. J. Physiol. Heart Circ. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL 073473-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bmyo protein, rat; 0 / DNA, Intergenic; 0 / RNA, Antisense; 0 / RNA, Messenger; 06LU7C9H1V / Triiodothyronine; 721M9407IY / Propylthiouracil; EC 3.6.1.- / Ventricular Myosins; EC 3.6.4.1 / Myosin Heavy Chains
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70. Kim SK, Park IK, Park BH, Park W, Lee HS, Kim TH, Jun JB, Bae SC, Yoo DH, Uhm WS: A case report: isolated a heavy chain monoclonal gammopathy in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin change syndrome. Int J Clin Pract Suppl; 2005 Apr;(147):26-30
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  • [Title] A case report: isolated a heavy chain monoclonal gammopathy in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin change syndrome.
  • A 45-year-old South-Korean man presented with abdominal distension, progressive paresthesia and motor weakness of both lower extremities.
  • Circulating M components of POEMS syndrome consist mainly of IgG or IgA-lambda and rarely IgM-lambda, IgG-kappa or isolated light chains.
  • In this case, the M-band on serum protein electrophoresis and isolated IgA heavy chain on serum immunofixation electrophoresis were demonstrated, but there was no abnormal light chain.
  • We suggest that this case may be associated with a pattern of abnormal secretion of monoclonal protein or a coincidence of a heavy chain disease in POEMS syndrome, even though the latter possibility may be very rare.
  • [MeSH-major] Heavy Chain Disease / diagnosis. POEMS Syndrome / diagnosis
  • [MeSH-minor] Bone Marrow / radionuclide imaging. Humans. Immunoglobulin A / blood. Immunoglobulin alpha-Chains / blood. Male. Middle Aged. Pleural Effusion / radiography. Pulmonary Atelectasis / radiography

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  • (PMID = 15875614.001).
  • [ISSN] 1368-504X
  • [Journal-full-title] International journal of clinical practice. Supplement
  • [ISO-abbreviation] Int J Clin Pract Suppl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulin A; 0 / Immunoglobulin alpha-Chains
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71. Landolsi A, Chabchoub I, Limem S, Gharbi O, Chaafai R, Hochlef M, Fatma LB, Trimech M, Krifa A, Ajmi S, Mokni M, Hadj Hmida MB, Ahmed SB: [Primary digestive tract lymphoma in central region of Tunisia: anatomoclinical study and therapeutic results about 153 cases]. Bull Cancer; 2010 Apr;97(4):435-43
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  • [Title] [Primary digestive tract lymphoma in central region of Tunisia: anatomoclinical study and therapeutic results about 153 cases].
  • [Transliterated title] Les lymphomes primitifs du tube digestif (LPTD) dans le centre tunisien: étude anatomoclinique et résultats thérapeutiques à propos de 153 cas.
  • Primary gastro-intestinal lymphoma (PGIL) is the most common type of extra-nodal non Hodgkin's lymphoma.
  • Their clinical and histological presentations are heterogeneous depending on the site of the lesion.
  • In our country epidemiology of the disease is unknown with IPSID being the most frequent type.
  • We report anatomo-clinical features and prognostic factors of PGIL and compare intestinal to gastric forms in our region.
  • Tumor sites were gastric (67%), intestinal (26%) and gastrointestinal (7%).
  • Abdominal pain (87%) followed by vomiting and diarrhoea (37 and 15%) were the most common symptoms.
  • Performance status (PS) < 2 was seen in 80% of patients, high grade lymphoma in 70.5% of cases and B phenotype was noted in 85%.
  • MALT lymphoma accounts for 50% of cases, and IPSID for only 5% of PGIL.
  • Only 46% of patients had surgery (14 for surgical complication, 6 for residual tumor after chemotherapy and 22 to have histological diagnosis).
  • In high grade lymphoma patients favorable prognostic factors for OS included young age < or = 60 years, PS < 2, normal serum LDH, hemoglobin > 12 g/dL, B phenotype, localised stage (IE-IIE1), anthracycline-based chemotherapy regimen, achieving complete or partial response to induction chemotherapy and no relapse.
  • In low-grade lymphoma patients, none of these factors had a significant correlation with OS: age < or = 60 years, PS < 2, stage (IE-IIE1), response to induction chemotherapy, relapse.
  • Compared to gastric lymphomas, intestinal cases occurred at a younger age, frequently with diarrhoea, weight loss, and occlusion.
  • We conclude that stomach is the main site of PGIL in our region, intestinal lymphoma is less frequent and IPSID has become rare.
  • [MeSH-major] Gastrointestinal Neoplasms. Lymphoma, Non-Hodgkin
  • [MeSH-minor] Abdominal Pain / etiology. Adolescent. Adult. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Diarrhea / etiology. Female. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Tunisia. Vomiting / etiology. Young Adult

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  • (PMID = 20395189.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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72. Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Assche GV, Ohresser M, Degenne D, Dugoujon JM, Jefferis R, Rutgeerts P, Lefranc MP, Watier H: IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab. Pharmacogenet Genomics; 2009 May;19(5):383-7
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  • [Title] IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.
  • OBJECTIVE: The chimeric anti-tumor necrosis factor-alpha antibody infliximab is known to induce antibodies-to-infliximab (ATI) in some treated patients.
  • Immunogenicity in murine variable domains is expected; however, constant domains of its human heavy gamma1 chain may also be implicated as it expresses G1m1 and G1m17 allotypes.
  • This allelic form may be immunogenic in patients that are homozygous for the G1m3 allotype commonly expressed in Caucasoid populations.
  • Two hundred forty-five blood donors and 118 previously described patients suffering from Crohn's disease, treated with infliximab, and having developed ATI in 73 of them, were genotyped.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Antibody Formation / genetics. Immunoglobulin G / genetics. Immunoglobulin Heavy Chains / genetics
  • [MeSH-minor] Anti-Inflammatory Agents / immunology. Anti-Inflammatory Agents / therapeutic use. Case-Control Studies. Cohort Studies. Crohn Disease / blood. Crohn Disease / drug therapy. Crohn Disease / genetics. Crohn Disease / immunology. Gene Frequency. Genotype. Humans. Immunoglobulin Allotypes / genetics. Infliximab. Models, Molecular

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  • (PMID = 19319024.001).
  • [ISSN] 1744-6872
  • [Journal-full-title] Pharmacogenetics and genomics
  • [ISO-abbreviation] Pharmacogenet. Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies, Monoclonal; 0 / Immunoglobulin Allotypes; 0 / Immunoglobulin G; 0 / Immunoglobulin Heavy Chains; B72HH48FLU / Infliximab
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73. Herron TJ, Vandenboom R, Fomicheva E, Mundada L, Edwards T, Metzger JM: Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes. Circ Res; 2007 Apr 27;100(8):1182-90
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  • [Title] Calcium-independent negative inotropy by beta-myosin heavy chain gene transfer in cardiac myocytes.
  • Increased relative expression of the slow molecular motor of the heart (beta-myosin heavy chain [MyHC]) is well known to occur in many rodent models of cardiovascular disease and in human heart failure.
  • To determine the direct effects of increased relative beta-MyHC expression on cardiac contractility, we used acute genetic engineering with a recombinant adenoviral vector (AdMYH7) to genetically titrate beta-MyHC protein expression in isolated rodent ventricular cardiac myocytes that predominantly expressed alpha-MyHC (fast molecular motor).
  • Gene transfer-based replacement of alpha-MyHC with beta-MyHC attenuated contractility in a dose-dependent manner, whereas calcium transients were unaffected.
  • Results indicate that small increases of beta-MyHC expression (18%) have Ca2+ transient-independent physiologically relevant effects to decrease intact cardiac myocyte function.

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  • (PMID = 17363698.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL60048; United States / NHLBI NIH HHS / HL / F32 HL080880; United States / NHLBI NIH HHS / HL / L30 HL082192; United States / NHLBI NIH HHS / HL / HL080880; United States / NIDDK NIH HHS / DK / 5P60 DK20572
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bmyo protein, rat; EC 3.6.1.- / Ventricular Myosins; EC 3.6.4.1 / Myosin Heavy Chains; SY7Q814VUP / Calcium
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74. Dekkers BG, Bos IS, Gosens R, Halayko AJ, Zaagsma J, Meurs H: The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am J Respir Crit Care Med; 2010 Mar 15;181(6):556-65
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  • MEASUREMENTS AND MAIN RESULTS: RGDS attenuated allergen-induced ASM hyperplasia and hypercontractility as well as increased pulmonary expression of smooth muscle myosin heavy chain and the proliferative marker proliferating cell nuclear antigen (PCNA).
  • In cultured human ASM cells, we demonstrated that proliferation induced by collagen I, fibronectin, serum, and platelet-derived growth factor requires signaling via RGD-binding integrins, particularly of the alpha(5)beta(1) subtype.
  • In addition, RGDS inhibited smooth muscle alpha-actin accumulation in serum-deprived ASM cells.
  • CONCLUSIONS: This is the first study indicating that integrins modulate ASM remodeling in an animal model of allergic asthma, which can be inhibited by a small peptide containing the RGD motif.
  • [MeSH-minor] Administration, Topical. Animals. Antibodies / immunology. Biomarkers. Blotting, Western. Cell Culture Techniques. Cell Proliferation / drug effects. Disease Models, Animal. Fibrosis / immunology. Guinea Pigs. Humans. Inflammation / immunology. Male. Muscle Contraction / drug effects. Proliferating Cell Nuclear Antigen / drug effects. Proliferating Cell Nuclear Antigen / immunology

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  • (PMID = 20019343.001).
  • [ISSN] 1535-4970
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Biomarkers; 0 / Oligopeptides; 0 / Platelet Aggregation Inhibitors; 0 / Proliferating Cell Nuclear Antigen; 91037-65-9 / arginyl-glycyl-aspartyl-serine
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75. Dogra C, Changotra H, Mohan S, Kumar A: Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein. J Biol Chem; 2006 Apr 14;281(15):10327-36
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  • Treatment of C2C12 myoblasts with TWEAK inhibited their differentiation evident by a decrease in the expression of creatine kinase, myosin heavy chain-fast twitch, myogenin, and the formation of multinucleated myotubes.
  • [MeSH-minor] Adenoviridae / genetics. Animals. Blotting, Western. Cell Differentiation. Cell Line. Cell Nucleus / metabolism. Cell Proliferation. Creatine Kinase / metabolism. Cyclin D1 / metabolism. Cytoplasm / metabolism. Dose-Response Relationship, Drug. Genes, Dominant. Hydroxyurea / metabolism. Hydroxyurea / pharmacology. I-kappa B Proteins / metabolism. Mice. Microscopy, Fluorescence. Models, Biological. Models, Statistical. Muscles / metabolism. Mutation. MyoD Protein / metabolism. Myogenin / metabolism. NF-kappa B / metabolism. Phosphorylation. Plasmids / metabolism. Protein Structure, Tertiary. Reverse Transcriptase Polymerase Chain Reaction. Signal Transduction. Time Factors

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  • (PMID = 16461349.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / I-kappa B Proteins; 0 / MyoD Protein; 0 / Myogenin; 0 / NF-kappa B; 0 / Tnfsf12 protein, mouse; 0 / Tumor Necrosis Factors; 136601-57-5 / Cyclin D1; 139874-52-5 / NF-kappaB inhibitor alpha; EC 2.7.3.2 / Creatine Kinase; X6Q56QN5QC / Hydroxyurea
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76. Chen CN, Li YS, Yeh YT, Lee PL, Usami S, Chien S, Chiu JJ: Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells. Proc Natl Acad Sci U S A; 2006 Feb 21;103(8):2665-70
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  • The phenotype of smooth muscle cells (SMCs) plays an important role in vascular function in health and disease.
  • Human aortic SMCs grown on polymerized collagen showed high expression levels of contractile markers (smooth muscle alpha-actin, myosin heavy chain, and calponin).

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  • (PMID = 16477012.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL080518; United States / NHLBI NIH HHS / HL / HL064385; United States / NHLBI NIH HHS / HL / HL080518
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-1; 0 / Platelet-Derived Growth Factor; 0 / Protein Kinase Inhibitors; 0 / Proto-Oncogene Proteins c-sis; 0 / Serum Response Factor; 0 / platelet-derived growth factor BB; 9007-34-5 / Collagen; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.1 / Ribosomal Protein S6 Kinases, 70-kDa
  • [Other-IDs] NLM/ PMC1413813
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77. Edes IF, Tóth A, Csányi G, Lomnicka M, Chłopicki S, Edes I, Papp Z: Late-stage alterations in myofibrillar contractile function in a transgenic mouse model of dilated cardiomyopathy (Tgalphaq*44). J Mol Cell Cardiol; 2008 Sep;45(3):363-72
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  • These mechanical alterations were paralleled by a robust increase in beta-myosin heavy chain expression in the Tgalphaq*44 hearts.
  • [MeSH-major] Cardiomyopathy, Dilated / genetics. Disease Models, Animal. GTP-Binding Protein alpha Subunits, Gq-G11 / genetics. Models, Cardiovascular. Myocardial Contraction / physiology. Myofibrils / physiology

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  • (PMID = 18674539.001).
  • [ISSN] 1095-8584
  • [Journal-full-title] Journal of molecular and cellular cardiology
  • [ISO-abbreviation] J. Mol. Cell. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 3.6.5.1 / GTP-Binding Protein alpha Subunits, Gq-G11
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78. Liu R, Zhang Y, Feng P: Multiresponsive supramolecular nanogated ensembles. J Am Chem Soc; 2009 Oct 28;131(42):15128-9
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  • The presence of UV light, alpha-CD, or disulfide reducing agent can effectively open the polymeric network and release the loading with different dynamics.

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  • (PMID = 19746981.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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79. Ilisz I, Fodor G, Iványi R, Szente L, Tóth G, Péter A: Enantioseparation of beta-methyl-substituted amino acids with cyclodextrins by capillary zone electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci; 2008 Nov 1;875(1):273-9
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  • Capillary zone electrophoresis was carried out using sulfopropylated-alpha-CD (SP2-alpha-CD), sulfopropylated-beta-CD (SP2-beta-CD) both with a degree of substitution of 2 moles/mole cyclodextrin, and sulfopropylated-beta-CD (SP4-beta-CD) with a degree of substitution of 4moles/mole beta-cyclodextrin.

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  • (PMID = 18514044.001).
  • [ISSN] 1570-0232
  • [Journal-full-title] Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • [ISO-abbreviation] J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Aminobutyrates; 0 / Cyclodextrins; 0 / beta-methyltryptophan; 2260-12-0 / 2-amino-3-phenylbutanoic acid; 42HK56048U / Tyrosine; 59-25-6 / beta-methyltyrosine; 8DUH1N11BX / Tryptophan
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80. Gómara B, García-Ruiz C, Marina ML: Enantioselective separation of the sunscreen agent 3-(4-methylbenzylidene)-camphor by electrokinetic chromatography: Quantitative analysis in cosmetic formulations. Electrophoresis; 2005 Oct;26(20):3952-9
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  • Different experimental conditions (type and concentration of the chiral selector, temperature, and sample solvent) have been optimized.
  • The addition of increasing concentrations of the neutral alpha-CD to CM-beta-CD at a 15 mM concentration in a 100 mM borate buffer at pH 9.0 improved the enantiomeric separation and decreased peak tailing.

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  • (PMID = 16217832.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cosmetics; 0 / Cyclodextrins; 0 / Sunscreening Agents; 76-22-2 / Camphor; 8I3XWY40L9 / enzacamene
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81. Lipka E, Danel C, Orhan H, Bonte JP, Vaccher C: Chiral resolution of melatoninergic ligands by EKC using highly sulfated CDs. Electrophoresis; 2007 Nov;28(21):3915-21
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  • EKC methods for the enantiomeric resolutions of melatoninergic ligands were developed using anionic CDs (highly S-alpha-CD, highly S-beta-CD, and highly S-gamma-CD) as chiral selectors at acidic pH 2.5.

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  • (PMID = 17922520.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Buffers; 0 / Cyclodextrins; 0 / Indicators and Reagents; 0 / Ligands; 0 / Sulfuric Acid Esters; 0 / Tetrahydronaphthalenes; 0 / beta-Cyclodextrins; JL5DK93RCL / Melatonin
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82. Wan P, Jiang Y, Wang Y, Wang Z, Zhang X: Tuning surface wettability through photocontrolled reversible molecular shuttle. Chem Commun (Camb); 2008 Nov 30;(44):5710-2
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  • A photocontrolled molecular shuttle SAM based on an alpha-cyclodextrin (alpha-CD)/azobenzene inclusion complex on rough gold surfaces is fabricated, which can reversibly switch the surface wettability by transferring external energy (light) to molecular mechanical motion.

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  • (PMID = 19009056.001).
  • [ISSN] 1364-548X
  • [Journal-full-title] Chemical communications (Cambridge, England)
  • [ISO-abbreviation] Chem. Commun. (Camb.)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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83. Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF: Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res; 2007 Jul 20;101(2):205-14
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  • Mutations in striated muscle alpha-tropomyosin (alpha-TM), an essential thin filament protein, cause both dilated cardiomyopathy (DCM) and familial hypertrophic cardiomyopathy.
  • Two distinct point mutations within alpha-tropomyosin are associated with the development of DCM in humans: Glu40Lys and Glu54Lys.
  • To investigate the functional consequences of alpha-TM mutations associated with DCM, we generated transgenic mice that express mutant alpha-TM (Glu54Lys) in the adult heart.
  • Results showed that an increase in transgenic protein expression led to a reciprocal decrease in endogenous alpha-TM levels, with total myofilament TM protein levels remaining unaltered.
  • Real-time RT-PCR quantification demonstrated an increased expression of beta-myosin heavy chain, brain natriuretic peptide, and skeletal actin and a decreased expression of the Ca(2+) handling proteins sarcoplasmic reticulum Ca(2+)-ATPase and ryanodine receptor.
  • Furthermore, our study also indicates that the alpha-TM54 mutation decreases tropomyosin flexibility, which may influence actin binding and myofilament Ca(2+) sensitivity.
  • [MeSH-minor] Actins / biosynthesis. Animals. Calcium-Transporting ATPases / biosynthesis. Disease Models, Animal. Echocardiography. Gene Expression Regulation / genetics. Humans. Mice. Mice, Mutant Strains. Mice, Transgenic. Muscle Contraction / genetics. Muscle Fibers, Skeletal / metabolism. Muscle Fibers, Skeletal / pathology. Natriuretic Peptide, Brain / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction. Ryanodine Receptor Calcium Release Channel / biosynthesis. Sarcoplasmic Reticulum / metabolism. Sarcoplasmic Reticulum / pathology. Ventricular Myosins / metabolism


84. Danel C, Lipka E, Bonte JP, Goossens JF, Vaccher C, Foulon C: Enantioseparation of chiral N-imidazole derivatives by electrokinetic chromatography using highly sulfated cyclodextrins: mechanism of enantioselective recognition. Electrophoresis; 2005 Oct;26(20):3824-32
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  • Baseline separation of ten new substituted [1-(imidazo-1-yl)-1-phenylmethyl)] benzothiazolinone and benzoxazolinone derivatives, with one chiral center, was achieved by CD-EKC using highly sulfated CDs (alpha, beta, gamma highly S-CDs) as chiral selectors.
  • The influence of the type and concentration of the chiral selectors on the enantioseparations was investigated.
  • The enantiomers were resolved with analysis times inferior to 2.5 min and resolution factors R(s) of 3.73, 3.90, 1.40, and 4.35 for compounds 1, 2, 3, and 5, respectively, using 25 mM phosphate buffer at pH 2.5 containing either highly S-alpha-CD, highly S-beta-CD, and highly S-gamma-CD (3 or 4% w/v) at 298 K, with an applied field of 0.30 kV/cm.

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  • (PMID = 16217831.001).
  • [ISSN] 0173-0835
  • [Journal-full-title] Electrophoresis
  • [ISO-abbreviation] Electrophoresis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Benzothiazoles; 0 / Benzoxazoles; 0 / Cyclodextrins; 0 / Imidazoles
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85. Park JW, Lee SY, Song HJ, Park KK: Self-inclusion behavior and circular dichroism of aliphatic chain-linked beta-cyclodextrin-viologen compounds and their reduced forms depending on the side of modification. J Org Chem; 2005 Nov 11;70(23):9505-13
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  • [Title] Self-inclusion behavior and circular dichroism of aliphatic chain-linked beta-cyclodextrin-viologen compounds and their reduced forms depending on the side of modification.
  • The self-inclusion behavior and induced circular dichroism (ICD) characteristics of two beta-cyclodextrin (beta-CD) derivatives, in which a 1-methyl-4,4'-bipyridinium (viologen) group is connected by an octamethylene chain to either the primary (2(2+)) or secondary (3(2+)) side of beta-CD, and of their reduced forms, are investigated.
  • 1H NMR studies showed that 2(2+) forms an intramolecular self-inclusion complex with K(in) = 3.1 +/- 0.4, whereas 3(2+) forms a head-to-head type of dimer with K(D) = 65 +/- 10 M(-1) at 25 degrees C. 2(2+) and 3(2+) form [2]pseudorotaxanes with alpha-CD, with the secondary side of the alpha-CD facing the viologen moiety.

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  • (PMID = 16268626.001).
  • [ISSN] 0022-3263
  • [Journal-full-title] The Journal of organic chemistry
  • [ISO-abbreviation] J. Org. Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Makino N, Toyofuku T, Takegahara N, Takamatsu H, Okuno T, Nakagawa Y, Kang S, Nojima S, Hori M, Kikutani H, Kumanogoh A: Involvement of Sema4A in the progression of experimental autoimmune myocarditis. FEBS Lett; 2008 Nov 26;582(28):3935-40
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  • Dendritic cells pulsed with myosin heavy chain-alpha peptides induced severe myocarditis in wild-type mice, but not in Sema4A-deficient mice.
  • In adoptive transfer experiments, CD4+ T-cells from wild-type mice induced severe myocarditis, while CD4+ T-cells from Sema4A-deficient mice exhibited considerably attenuated myocarditis.
  • [MeSH-major] Autoimmune Diseases / immunology. CD4-Positive T-Lymphocytes / immunology. Myocarditis / immunology. Semaphorins / physiology
  • [MeSH-minor] Adoptive Transfer. Animals. Cell Differentiation / genetics. Disease Models, Animal. Disease Progression. Disease Susceptibility. Lymphocyte Activation / genetics. Mice. Mice, Inbred BALB C. Mice, Knockout. Mice, SCID. Th1 Cells / immunology

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  • (PMID = 18977352.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Sema4A protein, mouse; 0 / Semaphorins
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87. Sharma N, Okere IC, Barrows BR, Lei B, Duda MK, Yuan CL, Previs SF, Sharov VG, Azimzadeh AM, Ernsberger P, Hoit BD, Sabbah H, Stanley WC: High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets. J Hypertens; 2008 Jul;26(7):1402-10
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  • Hypertension caused a switch in mRNA myosin heavy chain isoform from alpha to beta, and this effect was greater in the high-salt sucrose and fructose groups than in starch and fat groups.

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  • [ISSN] 0263-6352
  • [Journal-full-title] Journal of hypertension
  • [ISO-abbreviation] J. Hypertens.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL 074237; United States / NHLBI NIH HHS / HL / P01 HL074237-04; United States / NHLBI NIH HHS / HL / P01 HL074237; United States / NHLBI NIH HHS / HL / P01 HL074237-03; United States / NIDDK NIH HHS / DK / R33 DK070291; United States / NHLBI NIH HHS / HL / P01 HL074237-05; United States / NIDDK NIH HHS / DK / 1 R33 DK 070291-01; United States / NHLBI NIH HHS / HL / HL074237-03; United States / NHLBI NIH HHS / HL / HL074237-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dietary Carbohydrates; 0 / Dietary Fats; 0 / Dietary Sucrose; 0 / Sodium, Dietary; 30237-26-4 / Fructose; 57-50-1 / Sucrose
  • [Other-IDs] NLM/ NIHMS286825; NLM/ PMC3103886
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88. Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V: Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol; 2009 Feb 15;326(2):368-77
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  • Congenital heart disease is the most common type of birth defect with an incidence of 1%.
  • Previously, we described a point mutation in GATA4 that segregated with cardiac defects in a family with autosomal dominant disease.
  • Gene expression analyses were performed on both sets of compound heterozygotes and demonstrated downregulation of alpha-myosin heavy chain only in Gata4/Tbx5 heterozygotes.

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  • (PMID = 19084512.001).
  • [ISSN] 1095-564X
  • [Journal-full-title] Developmental biology
  • [ISO-abbreviation] Dev. Biol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / HL088965-02; United States / NHLBI NIH HHS / HL / R01 HL088965; United States / NHLBI NIH HHS / HL / R01 HL088965-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GATA4 Transcription Factor; 0 / GATA6 Transcription Factor; 0 / T-Box Domain Proteins; 0 / T-box transcription factor 5
  • [Other-IDs] NLM/ NIHMS95926; NLM/ PMC2651674
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89. Wamhoff BR, Bowles DK, Owens GK: Excitation-transcription coupling in arterial smooth muscle. Circ Res; 2006 Apr 14;98(7):868-78
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  • The primary function of the vascular smooth muscle cell (SMC) is contraction for which SMCs express a selective repertoire of genes (eg, SM alpha-actin, SM myosin heavy chain [SMMHC], myocardin) that ultimately define the SMC from other muscle cell types.
  • Moreover, the SMC exhibits extensive phenotypic diversity and plasticity, which play an important role during normal development, repair of vascular injury, and in vascular disease states.
  • For example, L-type voltage-gated Ca2+ channels modulate SMC differentiation marker gene expression, eg, SM alpha-actin and SMMHC, via Rho kinase and myocardin and also regulate c-fos gene expression independently via CaMK.
  • In addition, we discuss the potential role of IK channels and TRPC in ET-coupling as potential mediators of SMC phenotypic modulation, ie, negatively regulate SMC differentiation marker genes, in vascular disease.

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  • (PMID = 16614312.001).
  • [ISSN] 1524-4571
  • [Journal-full-title] Circulation research
  • [ISO-abbreviation] Circ. Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL071574; United States / NHLBI NIH HHS / HL / HL52490; United States / NHLBI NIH HHS / HL / P01 HL19242; United States / NHLBI NIH HHS / HL / R01 HL38854; United States / NHLBI NIH HHS / HL / R37 HL57353
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP Response Element-Binding Protein; 0 / Genetic Markers; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases
  • [Number-of-references] 77
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90. Toyama Y, Pais E, Meiselman HJ, Alexy T: Effects of cyclodextrins on RBC aggregation and blood viscosity. Clin Hemorheol Microcirc; 2007;36(2):173-80
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  • Cyclic oligomers of glucose, termed cyclodextrins (CDs), can contain 6 (alpha-CD), 7 (beta-CD) or 8 (gamma-CD) glucose units and are able to remove cholesterol from platelet membranes and decrease platelet aggregation.
  • Our results indicate the expected dose-dependent inhibition of platelet aggregation by beta-CD, with no significant effects of alpha-CD or gamma-CD.
  • RBC aggregation studies showed no effect of alpha-CD but highly significant (p<0.01) decreases by both beta-CD and gamma-CD; at the concentrations studied (1.5 x 10(-3) to 1.5 mM), beta-CD had somewhat greater effects.
  • Blood viscosity was not affected by alpha-CD, but was significantly decreased in a dose-dependent manner by beta-CD and, at the highest concentration (1.5 mM), by gamma-CD.

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  • (PMID = 17325441.001).
  • [ISSN] 1386-0291
  • [Journal-full-title] Clinical hemorheology and microcirculation
  • [ISO-abbreviation] Clin. Hemorheol. Microcirc.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL15722; United States / NHLBI NIH HHS / HL / HL70595
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Platelet Aggregation Inhibitors
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91. Suzaki Y, Taira T, Osakada K: Irreversible and reversible formation of a [2]rotaxane containing platinum(II) complex with an N-alkyl bipyridinium ligand as the axis component. Dalton Trans; 2006 Dec 7;(45):5345-51
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  • An N-Alkyl bipyridinium having a polymethylene chain and a bulky aryl group at the end, [4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2]Cl (Cl), reacts with K[PtCl3(dmso)] to produce the Pt complex with the N-alkyl bipyridinium ligand [Cl2(dmso)Pt{4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2}][PtCl3(dmso)] as a 6:1 mixture of trans and cis isomers ([trans-][PtCl3(dmso)] and [cis-][PtCl3(dmso)]).
  • Addition of alpha-cyclodextrin (alpha-CD) to a solution of Cl in dmso-d6/D2O (3:1) forms [2]pseudorotaxane [{4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2}.(alpha-CD)]Cl (Cl) which is equilibrated with Cl and alpha-CD in solution.
  • The reaction of K[PtCl3(dmso)] with Cl affords the [2]rotaxane [trans-Cl2(dmso)Pt{4,4'-bpy-N-(CH2)10OC6H(3)-3,5-tBu2}.(alpha-CD)][PtCl3(dmso)] ([trans-][PtCl3(dmso)]) which contains alpha-CD and [trans-][PtCl3(dmso)] as the cyclic and axis components, respectively.
  • Dissolution of a mixture of [trans-][PtCl3(dmso)], [cis-][PtCl3(dmso)] and alpha-CD in dmso-d6/D2O (3:1) forms a mixture of the rotaxanes containing [trans--d6][PtCl3(dmso)] and [cis--d6][PtCl3(dmso)].
  • The reaction involves partial dissociation of the bipyridinium from Pt of [trans-][PtCl3(dmso)] or [cis-][PtCl3(dmso)] to yield [PtCl3(dmso)] and formation of pseudorotaxane with alpha-CD, followed by recoordination of the bipyridinium to the Pt.

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  • (PMID = 17102859.001).
  • [ISSN] 1477-9226
  • [Journal-full-title] Dalton transactions (Cambridge, England : 2003)
  • [ISO-abbreviation] Dalton Trans
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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92. Wang F, Blanco E, Ai H, Boothman DA, Gao J: Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation. J Pharm Sci; 2006 Oct;95(10):2309-19
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  • For beta-lap and CD interactions, increasing complexation efficiency was observed in the order of alpha-CD, gamma-CD, and beta-CD. beta-Lap complexation with hydroxypropyl-beta-cyclodextrin (HPbeta-CD) prevented drug dissolution in PLGA, and led to fast release (79.6+/-2.1% after 2 days).
  • Sustained drug release was achieved when beta-lap was complexed with alpha-CD or gamma-CD.

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  • [Copyright] Copyright (c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association
  • (PMID = 16883563.001).
  • [ISSN] 0022-3549
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA142543; United States / NCI NIH HHS / CA / R01 CA102792; United States / NCI NIH HHS / CA / CA90696
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclodextrins; 0 / Naphthoquinones; 0 / Polymers; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid; 4707-32-8 / beta-lapachone
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93. Liu YX, Zhang X, Wu F, Deng NS: [Influence of cyclodextrins on the photodegradation of bisphenol A induced by Fe(III)]. Huan Jing Ke Xue; 2008 Mar;29(3):638-42
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  • Cyclodextrins (CDs) can form a host/guest inclusion complex with bisphenol A(BPA).
  • In the presence of alpha- cyclodextrin or beta-cyclodextrin (alpha-CD or beta-CD), the photodegradation efficiency of BPA can be enhanced, but gamma-cyclodextrin (gamma-CD) showed inhibitive effect on the photodegradation efficiency.
  • The initial degradation rate of BPA firstly increased with increasing concentration of beta-CD and alpha-CD from 0 to 60 micromol L(-1), and the maximum rate was reached at the beta-CD concentration of 60 micromol L(-1), and then decreased.

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  • (PMID = 18649520.001).
  • [ISSN] 0250-3301
  • [Journal-full-title] Huan jing ke xue= Huanjing kexue
  • [ISO-abbreviation] Huan Jing Ke Xue
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Cyclodextrins; 0 / Estrogens, Non-Steroidal; 0 / Ferric Compounds; 0 / Phenols; 0 / Water Pollutants, Chemical; 3352-57-6 / Hydroxyl Radical; MLT3645I99 / bisphenol A
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94. Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z: Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Am J Physiol Heart Circ Physiol; 2009 Dec;297(6):H2096-108
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  • [Title] Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.
  • We examined the nature and mechanism of the cardiomyopathy in Akita (Ins2(WT/C96Y)) mice, a model of genetic nonobese type 1 diabetes that recapitulates human type 1 diabetes.
  • Consistent with the lack of fibrosis, expression of procollagen-alpha type I, procollagen-alpha type III, and fibronectin were not increased in these hearts.
  • Ins2WT/C96Y hearts showed significantly reduced sarcoplasmic reticulum Ca2+-ATPase 2a (cardiac sarcoplasmic reticulum Ca2+ pump) levels, elevated beta-myosin heavy chain isoform, increased long-chain fatty acids, and triacylglycerol with evidence of lipotoxicity, as indicated by a significant rise in ceramide, diacylglycerol, and lipid deposits in the myocardium.
  • Consistent with metabolic perturbation, and a switch to fatty acid oxidation from glucose oxidation in Ins2WT/C96Y hearts, expression of mitochondrial long-chain acyl-CoA dehydrogenase and pyruvate dehydrogenase kinase isoform 4 were increased.
  • Insulin treatment reversed the diastolic dysfunction, the elevated B-type natriuretic peptide and beta-myosin heavy chain, and the reduced sarcoplasmic reticulum Ca2+-ATPase 2a levels with abolition of cardiac lipotoxicity.
  • We conclude that early type 1 diabetic cardiomyopathy is characterized by diastolic dysfunction associated with lipotoxic cardiomyopathy with preserved systolic function in the absence of interstitial fibrosis and hypertrophy.
  • [MeSH-major] Cardiomyopathies / genetics. Diabetes Mellitus, Type 1 / genetics. Insulin / genetics. Lipid Metabolism / genetics. Myocardial Contraction. Myocardium / metabolism. Ventricular Dysfunction, Left / genetics
  • [MeSH-minor] Acyl-CoA Dehydrogenase, Long-Chain / metabolism. Age Factors. Animals. Blood Glucose / metabolism. Ceramides / metabolism. Diastole. Diglycerides / metabolism. Disease Models, Animal. Disease Progression. Echocardiography, Doppler, Pulsed. Fatty Acids / metabolism. Hypoglycemic Agents / pharmacology. Male. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Mitochondria, Heart / metabolism. Myosin Heavy Chains / metabolism. Natriuretic Peptide, Brain / metabolism. Protein-Serine-Threonine Kinases / metabolism. Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism. Stroke Volume. Systole. Triglycerides / metabolism. Ventricular Pressure

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  • (PMID = 19801494.001).
  • [ISSN] 1522-1539
  • [Journal-full-title] American journal of physiology. Heart and circulatory physiology
  • [ISO-abbreviation] Am. J. Physiol. Heart Circ. Physiol.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / 84279; Canada / Canadian Institutes of Health Research / / 86602
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Bmyo protein, rat; 0 / Ceramides; 0 / Diglycerides; 0 / Fatty Acids; 0 / Hypoglycemic Agents; 0 / Insulin; 0 / Triglycerides; 114471-18-0 / Natriuretic Peptide, Brain; EC 1.3.8.8 / Acyl-CoA Dehydrogenase, Long-Chain; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.2 / pyruvate dehydrogenase (acetyl-transferring) kinase; EC 3.6.3.8 / Atp2a2 protein, rat; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases; EC 3.6.4.1 / Myosin Heavy Chains
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95. Stroud JL, Paton GI, Semple KT: Linking chemical extraction to microbial degradation of 14C-hexadecane in soil. Environ Pollut; 2008 Nov;156(2):474-81
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  • However, the novel HP-alpha-CD shake extraction showed close correlation (r(2)=0.90, n=36, p<0.05) to the mineralisation data.

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  • (PMID = 18316143.001).
  • [ISSN] 1873-6424
  • [Journal-full-title] Environmental pollution (Barking, Essex : 1987)
  • [ISO-abbreviation] Environ. Pollut.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Alkanes; 0 / Cyclodextrins; 0 / Soil; 0 / Soil Pollutants; F8Z00SHP6Q / n-hexadecane
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96. Heitner JC, Koy C, Kreutzer M, Gerber B, Reimer T, Glocker MO: Differentiation of HELLP patients from healthy pregnant women by proteome analysis--on the way towards a clinical marker set. J Chromatogr B Analyt Technol Biomed Life Sci; 2006 Aug 7;840(1):10-9
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  • [Title] Differentiation of HELLP patients from healthy pregnant women by proteome analysis--on the way towards a clinical marker set.
  • A specific plasma protein profile for the HELLP-syndrome was generated involving protein areas that contain inter-alpha-trypsin inhibitor heavy chain H4, kininogen 1, fibrinogen gamma chain, transthyretin, haptoglobins, and serum amyloid A with statistically significant expression differences when compared to controls.
  • It now is possible to clinically elucidate if the differentially expressed proteins are suited for longitudinal studies concerning both, to function as markers or perhaps even as disease predictors that might become relevant for diagnostic tests.

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  • (PMID = 16837253.001).
  • [ISSN] 1570-0232
  • [Journal-full-title] Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • [ISO-abbreviation] J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Proteome
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97. Dudekula S, Fragata M: Investigation of the electron transfer site of p-benzoquinone in isolated photosystem II particles and thylakoid membranes using alpha- and beta-cyclodextrins. J Photochem Photobiol B; 2006 Dec 1;85(3):177-83
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  • [Title] Investigation of the electron transfer site of p-benzoquinone in isolated photosystem II particles and thylakoid membranes using alpha- and beta-cyclodextrins.
  • The electron transfer sites of p-benzoquinone (pBQ) and 2,6-dichloro-p-benzoquinone (DCBQ) were investigated in thylakoid membranes and isolated photosystem II (PSII) particles from barley (Hordeum vulgare) using alpha- and beta-cyclodextrins (CD) at concentrations up to 16 mM.
  • The maxima percent OE enhancement at cyclodextrin concentrations above 14 mM are about 100% (alpha-CD) and 190% (beta-CD).
  • It was also found that in isolated PSII particles incubated with either pBQ or DCBQ the cyclodextrins induce only a small OE enhancement.
  • [MeSH-minor] Kinetics. alpha-Cyclodextrins / chemistry. beta-Cyclodextrins / chemistry

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  • (PMID = 16934484.001).
  • [ISSN] 1011-1344
  • [Journal-full-title] Journal of photochemistry and photobiology. B, Biology
  • [ISO-abbreviation] J. Photochem. Photobiol. B, Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Benzoquinones; 0 / Photosystem II Protein Complex; 0 / alpha-Cyclodextrins; 0 / beta-Cyclodextrins; 3T006GV98U / benzoquinone; 697-91-6 / 2,6-dichlorobenzoquinone; S88TT14065 / Oxygen
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98. Bone S: Dielectric studies of water clusters in cyclodextrins: Relevance to the transition between slow and fast forms of thrombin. J Phys Chem B; 2006 Oct 19;110(41):20609-14
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  • In alpha-cyclodextrin hexahydrate (alpha-CD.6H2O), water molecules are ordered and occupy well-defined positions whereas in the larger beta-cyclodextrin dodecahydrate (beta-CD.12H2O), there is considerable disorder with water molecules freely arranged over several possible sites.
  • Here it is shown that beta-CD exhibits substantial structural flexibility and proton mobility compared with alpha-CD which is relatively very rigid and exhibits negligible short-range protonic conduction.

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  • (PMID = 17034250.001).
  • [ISSN] 1520-6106
  • [Journal-full-title] The journal of physical chemistry. B
  • [ISO-abbreviation] J Phys Chem B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Enzymes; 0 / Protons; 059QF0KO0R / Water; EC 3.4.21.5 / Thrombin
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99. Osaki M, Takashima Y, Yamaguchi H, Harada A: An artificial molecular chaperone: poly-pseudo-rotaxane with an extensible axle. J Am Chem Soc; 2007 Nov 21;129(46):14452-7
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  • Poly-pseudo-rotaxanes CDs contains as a subset 1 (CDs; cyclodextrins, 1; poly(delta-valerolactone) having single beta-CD at the end of the polymer chain) initiate polymerization of delta-valerolactone (delta-VL) in the solid state when CDs (alpha-CD, beta-CD, and 2,6-di-O-methyl-beta-CD) are threaded onto the polymer chain.
  • The polymer chain of beta-CD contains as a subset 1 was found to elongate in the solid state, whereas the polymer chain of 1 formed a random coil conformation.
  • 1 was deactivated for the polymerization by blocking the active cavity of beta-CD with the polymer chain.
  • CDs threaded onto 1 are immune to the initiation of delta-VL directly but have an essential role to fold the polymer chain in a proper way as an artificial chaperone.

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  • (PMID = 17973382.001).
  • [ISSN] 0002-7863
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclodextrins; 0 / Lactones; 0 / Molecular Chaperones; 0 / Polymers; 0 / Rotaxanes
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100. Fiaccavento R, Carotenuto F, Minieri M, Masuelli L, Vecchini A, Bei R, Modesti A, Binaglia L, Fusco A, Bertoli A, Forte G, Carosella L, Di Nardo P: Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters. Am J Pathol; 2006 Dec;169(6):1913-24
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  • [Title] Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters.
  • Randomized clinical trials have demonstrated that the increased intake of omega-3 polyunsaturated fatty acids significantly reduces the risk of ischemic cardiovascular disease, but no investigations have been performed in hereditary cardiomyopathies with diffusely damaged myocardium.
  • In the present study, delta-sarcoglycan-null cardiomyopathic hamsters were fed from weaning to death with an alpha-linolenic acid (ALA)-enriched versus standard diet.
  • In fact, ALA administration preserved plasmalemma and mitochondrial membrane integrity, thus maintaining proper cell/extracellular matrix contacts and signaling, as well as a normal gene expression profile (myosin heavy chain isoforms, atrial natriuretic peptide, transforming growth factor-beta1) and a limited extension of fibrotic areas within ALA-fed cardiomyopathic hearts.
  • [MeSH-major] Cardiomegaly / diet therapy. Cardiomyopathies / diet therapy. Dietary Fats, Unsaturated / therapeutic use. Fatty Acids, Omega-3 / therapeutic use. alpha-Linolenic Acid / therapeutic use
  • [MeSH-minor] Animals. Cricetinae. Disease Models, Animal. Endomyocardial Fibrosis / pathology. Endomyocardial Fibrosis / prevention & control. Fatty Acids / blood. Longevity. Myocardial Contraction

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  • (PMID = 17148657.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats, Unsaturated; 0 / Fatty Acids; 0 / Fatty Acids, Omega-3; 0RBV727H71 / alpha-Linolenic Acid
  • [Other-IDs] NLM/ PMC1762468
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