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1. Schillaci G, De Socio GV, Pucci G, Mannarino MR, Helou J, Pirro M, Mannarino E: Aortic stiffness in untreated adult patients with human immunodeficiency virus infection. Hypertension; 2008 Aug;52(2):308-13
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  • [Title] Aortic stiffness in untreated adult patients with human immunodeficiency virus infection.
  • In 39 untreated HIV-infected patients and 78 individually matched age-, sex-, and blood pressure-matched HIV-uninfected control subjects, we determined aortic pulse wave velocity (PWV), a direct noninvasive measure of aortic stiffness, by tonometric method.
  • [MeSH-minor] Adult. Case-Control Studies. Female. Follow-Up Studies. Humans. Linear Models. Male. Multivariate Analysis. Pulsatile Flow. Reference Values. Risk Factors. Severity of Illness Index. Vascular Resistance / physiology

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  • (PMID = 18559718.001).
  • [ISSN] 1524-4563
  • [Journal-full-title] Hypertension (Dallas, Tex. : 1979)
  • [ISO-abbreviation] Hypertension
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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2. Rashtak S, Ettore MW, Homburger HA, Murray JA: Combination testing for antibodies in the diagnosis of coeliac disease: comparison of multiplex immunoassay and ELISA methods. Aliment Pharmacol Ther; 2008 Sep 15;28(6):805-13
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  • METHODS: We compared the sensitivity, specificity and accuracy of MIA and ELISA methods for TTG and DGP antibodies in mainly adult untreated coeliac patients (n = 92) and controls (n = 124).

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  • (PMID = 19145736.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / DK-057892; United States / NIDDK NIH HHS / DK / DK057892-07; United States / NIDDK NIH HHS / DK / R01 DK057892; United States / NIDDK NIH HHS / DK / R01 DK057892-07; United States / NIDDK NIH HHS / DK / R01 DK057892-08
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Immunoglobulin A; 0 / Immunoglobulin G
  • [Other-IDs] NLM/ NIHMS73354; NLM/ PMC2666354
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3. Tournis ST, Giannikou PV, Paspati IN, Katsalira EA, Voskaki IC, Lyritis GP: Co-existence of X-linked hypophosphatemic rickets (XLH) and primary hyperparathyroidism: case report and review of the literature. J Musculoskelet Neuronal Interact; 2005 Jun;5(2):150-4
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  • We report a case of an adult untreated male XLH patient with primary HPT and give a brief review of the literature regarding the prevalence and pathophysiology of this complication.

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  • (PMID = 15951631.001).
  • [ISSN] 1108-7161
  • [Journal-full-title] Journal of musculoskeletal & neuronal interactions
  • [ISO-abbreviation] J Musculoskelet Neuronal Interact
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Parathyroid Hormone
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4. Zicha J, Dobesová Z, Kunes J: Late blood pressure reduction in SHR subjected to transient captopril treatment in youth: possible mechanisms. Physiol Res; 2008;57(3):495-8
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  • Adult untreated SHR aged 30-34 weeks were compared with animals subjected to chronic captopril treatment for 6 weeks either in youth (between 4 and 10 weeks of age) or in adulthood (between 24 and 30 weeks of age).
  • Antihypertensive effects of captopril were more pronounced in young than adult SHR.
  • The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal.

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  • (PMID = 18597587.001).
  • [ISSN] 0862-8408
  • [Journal-full-title] Physiological research
  • [ISO-abbreviation] Physiol Res
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Angiotensin-Converting Enzyme Inhibitors; 0 / Antihypertensive Agents; 0 / Vasodilator Agents; 9G64RSX1XD / Captopril; I9ZF7L6G2L / Nifedipine
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5. Rees J, Watt H, Jäger HR, Benton C, Tozer D, Tofts P, Waldman A: Volumes and growth rates of untreated adult low-grade gliomas indicate risk of early malignant transformation. Eur J Radiol; 2009 Oct;72(1):54-64
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  • [Title] Volumes and growth rates of untreated adult low-grade gliomas indicate risk of early malignant transformation.
  • Adult low-grade gliomas (LGG) grow slowly, but most eventually undergo malignant transformation.
  • Twenty-seven patients with biopsy-proven, untreated LGG had at least three MRI studies at 6 monthly intervals.
  • [MeSH-minor] Adult. Aged. Cell Transformation, Neoplastic / pathology. Female. Humans. Image Enhancement / methods. Male. Middle Aged. Reproducibility of Results. Risk Assessment. Risk Factors. Sensitivity and Specificity

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  • (PMID = 18632238.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Grant] United Kingdom / Department of Health / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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6. Leathwick DM, Miller CM, Atkinson DS, Haack NA, Waghorn TS, Oliver AM: Managing anthelmintic resistance: untreated adult ewes as a source of unselected parasites, and their role in reducing parasite populations. N Z Vet J; 2008 Aug;56(4):184-95
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  • [Title] Managing anthelmintic resistance: untreated adult ewes as a source of unselected parasites, and their role in reducing parasite populations.
  • AIMS: To test the hypotheses that when untreated adult ewes are rotationally grazed (follow behind) on pastures after lambs receiving routine anthelmintic treatments, the ewes can function as a source of unselected parasites in refugia, capable of slowing the development of anthelmintic resistance, and suppress the build-up of parasites resulting from the development of anthelmintic resistance.
  • METHODS: Firstly, the potential of untreated adult ewes to slow the development of anthelmintic resistance, and to suppress parasite populations under differing levels of anthelmintic efficacy, was investigated using a simulation model.
  • RESULTS: Model simulations indicated that parasites cycling in the untreated ewes could slow the development of resistance being selected for by the anthelmintic treatments given to lambs and this could occur without a nett increase in larval numbers on pasture.
  • In the field trial, untreated adult ewes contributed to pasture infestations of most parasite species, but not Nematodirus spp.
  • CONCLUSIONS: Untreated adult ewes were a source of unselected genotypes, capable of slowing the development of anthelmintic resistance in most, but not all, parasite species.
  • Further, the potential of adult ewes to remove from pasture more parasite larvae than they contribute through faecal contamination indicates a potentially useful role in suppressing parasite populations, particularly when worm control in lambs is less effective as a result of anthelmintic resistance.

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  • (PMID = 18690255.001).
  • [ISSN] 0048-0169
  • [Journal-full-title] New Zealand veterinary journal
  • [ISO-abbreviation] N Z Vet J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Anthelmintics
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7. Weber J, Collmann H, Czarnetzki A, Spring A, Pusch CM: Morphometric analysis of untreated adult skulls in syndromic and nonsyndromic craniosynostosis. Neurosurg Rev; 2008 Apr;31(2):179-88
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  • [Title] Morphometric analysis of untreated adult skulls in syndromic and nonsyndromic craniosynostosis.
  • The aim of this study was to perform a morphometric analysis of untreated adult skulls displaying syndromic and nonsyndromic craniosynostosis.
  • We analyzed, in detail, 42 adult craniosynostoses (18 scaphocephaly, 11 anterior plagiocephaly, 2 trigonocephaly, 9 oxycephaly, and 2 brachycephaly) from archeological (three skulls) and pathoanatomical samples (39 skulls).
  • The mean cranial length in adult scaphocephaly was 12% greater than anatomical skulls.
  • These data on adult craniosynostosis could be of interest for physicians dealing with craniosynostotic children.
  • [MeSH-minor] Adult. Archaeology. Biological Specimen Banks. Cerebrovascular Disorders / pathology. DNA / biosynthesis. DNA / genetics. Humans. Intracranial Hypertension / pathology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17992550.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 9007-49-2 / DNA
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8. Krasinskas AM, Demetris AJ, Poterucha JJ, Abraham SC: The prevalence and natural history of untreated isolated central perivenulitis in adult allograft livers. Liver Transpl; 2008 May;14(5):625-32
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  • [Title] The prevalence and natural history of untreated isolated central perivenulitis in adult allograft livers.
  • Central perivenulitis (CP) in the allograft liver can be associated with portal-based acute cellular rejection and autoimmune hepatitis or can occur in isolation (isolated CP).
  • Although several studies have demonstrated the significance of CP, the prevalence and natural history of untreated isolated CP have not been well studied.
  • We examined 100 adult allograft liver recipients who had long-term follow-up, had routine protocol biopsies, and received no treatment for isolated CP.
  • Nearly all (94%) cases of late isolated CP occurred in patients who had early episodes of CP and/or acute cellular rejection.
  • In summary, "transplant-associated" isolated CP occurs in 28% of adult patients, early CP is predictive of late CP, and late CP (often present as isolated CP) is associated with long-term liver injury in some patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Bile Ducts / pathology. Disease Progression. Female. Follow-Up Studies. Humans. Male. Middle Aged. Necrosis. Prevalence. Reoperation. Risk Factors. Severity of Illness Index. Time Factors. Transplantation, Homologous. Venules / pathology

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  • [CommentIn] Liver Transpl. 2008 May;14(5):596-600 [18433067.001]
  • (PMID = 18433038.001).
  • [ISSN] 1527-6473
  • [Journal-full-title] Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • [ISO-abbreviation] Liver Transpl.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Laron Z, Ginsberg S, Lilos P, Arbiv M, Vaisman N: Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity). Clin Endocrinol (Oxf); 2006 Jul;65(1):114-7
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  • [Title] Body composition in untreated adult patients with Laron syndrome (primary GH insensitivity).
  • OBJECTIVE: To quantify body adiposity and its distribution in untreated adult patients with Laron syndrome (LS; primary GH insensitivity) caused by molecular defects of the GH receptor gene or postreceptor pathways and characterized by dwarfism, obesity, insulin resistance and hyperlipidaemia.
  • [MeSH-minor] Absorptiometry, Photon. Adult. Body Mass Index. Case-Control Studies. Female. Humans. Insulin-Like Growth Factor I / deficiency. Lipids / blood. Male. Middle Aged. Sex Factors. Statistics, Nonparametric

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  • (PMID = 16817829.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Lipids; 67763-96-6 / Insulin-Like Growth Factor I
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10. Chen DY, Lan JL, Lin FJ, Hsieh TY: Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Still's disease. Clin Rheumatol; 2007 Mar;26(3):393-400
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  • [Title] Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Still's disease.
  • To investigate serum levels of soluble Fas (sFas), soluble Fas ligand (sFas-L), and matrix metalloproteinase-3 (MMP-3) in patients with active untreated adult onset Still's disease (AOSD).
  • Serum levels of sFas, sFas-L, and MMP-3 were determined by enzyme-linked immunosorbent assays in 20 patients with active untreated AOSD, 20 patients with active rheumatoid arthritis (RA), and 20 healthy controls.
  • Significantly higher levels of sFas, sFas-L, and MMP-3 in sera were found in active untreated AOSD patients compared to healthy controls.
  • Serum levels of sFas, sFas-L, and MMP-3 fluctuated and were found to be parallel to disease activity of AOSD. sFas, sFas-L, and MMP-3, which were significantly elevated in sera of active untreated AOSD patients and paralleled disease activity, may be involved in the pathogenesis of this disease.
  • [MeSH-major] Antigens, CD95 / blood. Fas Ligand Protein / blood. Matrix Metalloproteinase 3 / blood. Still's Disease, Adult-Onset / blood
  • [MeSH-minor] Adult. Arthritis, Rheumatoid / blood. Case-Control Studies. Female. Humans. Male. Middle Aged

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  • (PMID = 16972019.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / FAS protein, human; 0 / FASLG protein, human; 0 / Fas Ligand Protein; EC 3.4.24.17 / Matrix Metalloproteinase 3
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11. Jenkinson MD, Smith TS, Haylock B, Husband D, Shenoy A, Vinjamuri S, Walker C, Pietronigro D, Warnke PC: Phase II trial of intratumoral BCNU injection and radiotherapy on untreated adult malignant glioma. J Neurooncol; 2010 Aug;99(1):103-13
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  • [Title] Phase II trial of intratumoral BCNU injection and radiotherapy on untreated adult malignant glioma.

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  • (PMID = 20063175.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; 0Z5B2CJX4D / Fluorodeoxyglucose F18; AD84R52XLF / Thallium; U68WG3173Y / Carmustine
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12. Eslambolchi S, Woodside DG, Rossouw PE: A descriptive study of mandibular incisor alignment in untreated subjects. Am J Orthod Dentofacial Orthop; 2008 Mar;133(3):343-53

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A descriptive study of mandibular incisor alignment in untreated subjects.
  • METHODS: In this study, we describe the longitudinal dental changes in untreated children (n = 15) who had records at 3 times and in an untreated adult group (n = 18) (parents) who had records for 2 times.
  • CONCLUSIONS: These results underline the importance of studies showing that untreated dentitions change over time.
  • [MeSH-minor] Adolescent. Adult. Cephalometry. Child. Female. Humans. Longitudinal Studies. Male. Maxillofacial Development / physiology. Odontometry

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  • (PMID = 18331931.001).
  • [ISSN] 1097-6752
  • [Journal-full-title] American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
  • [ISO-abbreviation] Am J Orthod Dentofacial Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Vieira TC, da Silva MR, Abucham J: The natural history of the R120C PROP1 mutation reveals a wide phenotypic variability in two untreated adult brothers with combined pituitary hormone deficiency. Endocrine; 2006 Dec;30(3):365-9

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  • [Title] The natural history of the R120C PROP1 mutation reveals a wide phenotypic variability in two untreated adult brothers with combined pituitary hormone deficiency.
  • METHODS: Clinical follow-up and molecular analysis of PROP1 in two adult brothers with CPHD, born from consanguineous parents, and not treated until late adulthood.
  • [MeSH-minor] Adult. Brazil. DNA Mutational Analysis. Humans. Male. Mutation, Missense. Phenotype

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  • (PMID = 17526949.001).
  • [ISSN] 1355-008X
  • [Journal-full-title] Endocrine
  • [ISO-abbreviation] Endocrine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / Pituitary Hormones; 0 / Prophet of Pit-1 protein
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14. Wu YJ, Li JY, Zhu MQ, Song JH, Zheng WJ: [Application of a four antibody (cMPO/cCD79aalpha/cCD3/CD45) combination to the diagnosis of acute leukemia expressing cross-lineage antigens]. Zhonghua Xue Ye Xue Za Zhi; 2006 Jul;27(7):449-51
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  • [Title] [Application of a four antibody (cMPO/cCD79aalpha/cCD3/CD45) combination to the diagnosis of acute leukemia expressing cross-lineage antigens].
  • OBJECTIVE: To explore the diagnostic value of intracellular antibody combination in acute leukemia (AL) expressing cross-lineage cell-surface antigens.
  • METHODS: Flow cytometric immunophenotyping using intracellular antibody combination (cMPO/cCD79alpha/cCD3/CD45) was performed additionally in 60 patients who expressed cross-lineage antigens from 269 previously untreated adult AL.
  • RESULTS: Fifty-four of 269 previously untreated adult AL patients who expressed only one kind of intracellular antigen were diagnosed as cross-lineage AL, the percentage of cross-lineage AL in T cell acute lymphoblastic leukemia (T-ALL), B-ALL and acute myeloid leukemia (AML) was 28.6%, 43.6% and 13.4%, respectively.
  • [MeSH-major] Antibodies, Monoclonal. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD3 / immunology. Antigens, CD45 / immunology. Antigens, CD79 / immunology. Antigens, Surface / immunology. Cross Reactions. Female. Flow Cytometry. Humans. Immunophenotyping. Male. Middle Aged. Sensitivity and Specificity

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  • (PMID = 17147246.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, CD3; 0 / Antigens, CD79; 0 / Antigens, Surface; EC 3.1.3.48 / Antigens, CD45
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15. Erba HP, Kantarjian HM, Claxton DF, Arellano M, Lyons RM, Kovacsovics TJ, Gabrilove J, Eckert S, Faderl S: Updated remission duration and survival results of single-agent clofarabine in previously untreated older adult patients with acute myelogenous leukemia (AML) unlikely to benefit from standard induction chemotherapy due to unfavorable baseline risk factor(s). J Clin Oncol; 2009 May 20;27(15_suppl):7062

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Updated remission duration and survival results of single-agent clofarabine in previously untreated older adult patients with acute myelogenous leukemia (AML) unlikely to benefit from standard induction chemotherapy due to unfavorable baseline risk factor(s).
  • METHODS: Single arm, multi-center, phase II, open-label, 2-stage study of patients with untreated AML, ≥60 years old, and at least one adverse prognostic factor: age ≥70 years, antecedent hematologic disorder (AHD), PS = 2, and/or intermediate/unfavorable risk karyotype.
  • CONCLUSIONS: These data expand on the previously reported efficacy and safety data of single agent CLO in adult AML.
  • These results suggest that single agent CLO is an effective and tolerable treatment option for older adult patients with untreated AML and 1 or more unfavorable baseline prognostic factor(s).

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  • (PMID = 27961436.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Slotte C, Lundgren D, Sennerby L: Bone morphology and vascularization of untreated and guided bone augmentation-treated rabbit calvaria: evaluation of an augmentation model. Clin Oral Implants Res; 2005 Apr;16(2):228-35

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bone morphology and vascularization of untreated and guided bone augmentation-treated rabbit calvaria: evaluation of an augmentation model.
  • To our knowledge, however, few studies on the characteristics of the untreated calvaria regarding bone density, vessel topography, and their intra/interindividual variations and associations are available.
  • The aims of this investigation were to (1) map the large vessel topography of the skull vault, (2) describe the parietal bones of the adult rabbit histologically and morphometrically, and (3) histologically compare untreated parietal bone with parietal bone that had been treated with a GBA device.
  • MATERIAL AND METHODS: Ten adult untreated rabbits were microangiographed.
  • In addition, sections from 14 GBA-treated rabbit skulls (of the same race, sex and age as the untreated animals) served as reference specimens for comparison.
  • Hollow connections were frequently found in both the outer and inner cortical plates in both the untreated and the GBA-treated specimens.
  • The morphometric measurements revealed similar proportions of cortical, trabecular, and marrow areas in the right and left untreated bones.
  • Bone density was similar in the right and left untreated and GBA-treated specimens, as was the frequency and width of hollow connections through the cortical bone plates.

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  • (PMID = 15777333.001).
  • [ISSN] 0905-7161
  • [Journal-full-title] Clinical oral implants research
  • [ISO-abbreviation] Clin Oral Implants Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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17. Nielsen OS, Reichardt P, Christensen TB, Pink D, Daugaard S, Hermans C, Marreaud S, van Glabbeke M, Blay J, Judson I: Phase 1 European Organisation for Research and Treatment of Cancer study determining safety of pegylated liposomal doxorubicin (Caelyx) in combination with ifosfamide in previously untreated adult patients with advanced or metastatic soft tissue sarcomas. Eur J Cancer; 2006 Sep;42(14):2303-9
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  • [Title] Phase 1 European Organisation for Research and Treatment of Cancer study determining safety of pegylated liposomal doxorubicin (Caelyx) in combination with ifosfamide in previously untreated adult patients with advanced or metastatic soft tissue sarcomas.
  • [MeSH-minor] Adolescent. Adult. Aged. Dose-Response Relationship, Drug. Doxorubicin / administration & dosage. Doxorubicin / adverse effects. Female. Humans. Ifosfamide / administration & dosage. Ifosfamide / adverse effects. Male. Middle Aged. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 16891112.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 80168379AG / Doxorubicin; UM20QQM95Y / Ifosfamide
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18. Ling Y, Cao X, Yu Z, Ruan C: Circulating dendritic cells subsets and CD4+Foxp3+ regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome. Eur J Haematol; 2007 Oct;79(4):310-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating dendritic cells subsets and CD4+Foxp3+ regulatory T cells in adult patients with chronic ITP before and after treatment with high-dose dexamethasome.
  • In this study, we investigated the amounts of circulating myeloid DCs (mDCs), plasmacytoid DCs (pDCs), and CD4(+)Foxp3(+) Treg cells in 26 untreated adult patients with chronic ITP.
  • [MeSH-minor] Adult. Antigens, CD11c / immunology. CD4 Lymphocyte Count. Chronic Disease. Down-Regulation / drug effects. Female. Humans. Immunosuppression. Male. Middle Aged. Myeloid Cells / immunology. Myeloid Cells / pathology. Plasma Cells / immunology. Plasma Cells / pathology. Platelet Count

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  • (PMID = 17692100.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD11c; 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors; 0 / Glucocorticoids; 7S5I7G3JQL / Dexamethasone
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19. Falini ML, Elli L, Caramanico R, Bardella MT, Terrani C, Roncoroni L, Doneda L, Forlani F: Immunoreactivity of antibodies against transglutaminase-deamidated gliadins in adult celiac disease. Dig Dis Sci; 2008 Oct;53(10):2697-701
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  • [Title] Immunoreactivity of antibodies against transglutaminase-deamidated gliadins in adult celiac disease.
  • AIM: To determine the immunoreactivity of anti-gliadin antibodies from untreated celiac patients to transglutaminase deamidated gliadins.
  • Immunoreactivity of anti-gliadin antibodies from untreated adult celiac patients sera was evaluated by means of a competitive enzyme-linked immunosorbent assay (ELISA) method.
  • CONCLUSIONS: Increased immunoreactivity of transglutaminase deamidated gliadins tested with anti-gliadin antibodies from untreated adult celiac patients supports the hypothesis of a pivotal role of gliadin deamidation in the pathomechanism of celiac disease.
  • [MeSH-minor] Adult. Cysteamine / metabolism. Deamination / drug effects. Enzyme-Linked Immunosorbent Assay. Female. Humans. Male

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  • (PMID = 18306039.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 5UX2SD1KE2 / Cysteamine; 9007-90-3 / Gliadin; EC 2.3.2.13 / Transglutaminases
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20. Nowakowski J, McKenna D, Nadelman RB, Bittker S, Cooper D, Pavia C, Holmgren D, Visintainer P, Wormser GP: Blood cultures for patients with extracutaneous manifestations of Lyme disease in the United States. Clin Infect Dis; 2009 Dec 1;49(11):1733-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, blood culture results were positive for 5 (19.2%; 95% confidence interval, 6.6%-39.4%) of 26 untreated adult patients with extracutaneous manifestations but only for patients with clinical evidence for a short duration of infection.
  • [MeSH-minor] Adult. Borrelia burgdorferi / physiology. Erythema Chronicum Migrans / microbiology. Erythema Chronicum Migrans / pathology. Female. Humans. Lyme Neuroborreliosis / blood. Lyme Neuroborreliosis / microbiology. Lyme Neuroborreliosis / pathology. Male. Middle Aged. United States

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  • (PMID = 19886794.001).
  • [ISSN] 1537-6591
  • [Journal-full-title] Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • [ISO-abbreviation] Clin. Infect. Dis.
  • [Language] eng
  • [Grant] United States / PHS HHS / / CCU 21962
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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21. Goetz AK, Rockett JC, Ren H, Thillainadarajah I, Dix DJ: Inhibition of rat and human steroidogenesis by triazole antifungals. Syst Biol Reprod Med; 2009 Dec;55(5-6):214-26
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  • Hormone production was measured in testis organ cultures from untreated adult and neonatal rats, following in vitro exposure to 1, 10, or 100 muM of myclobutanil or triadimefon.
  • Myclobutanil and triadimefon reduced media levels of testosterone by 40-68% in the adult and neonatal testis culture, and altered steroid production in a manner that indicated CYP17-hydroxylase/17,20 lyase (CYP17A1) inhibition at the highest concentration tested.

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  • (PMID = 19938956.001).
  • [ISSN] 1939-6376
  • [Journal-full-title] Systems biology in reproductive medicine
  • [ISO-abbreviation] Syst Biol Reprod Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Nitriles; 0 / Steroids; 0 / Triazoles; 0 / systhane; 142KW8TBSR / propiconazole; 3XMK78S47O / Testosterone; 43121-43-3 / triadimefon; EC 1.14.99.9 / CYP17A1 protein, human; EC 1.14.99.9 / Steroid 17-alpha-Hydroxylase
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22. Ginsberg S, Laron Z, Bed MA, Vaisman N: The obesity of patients with Laron Syndrome is not associated with excessive nutritional intake. Obes Res Clin Pract; 2009 Mar;3(1):1-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUMMARY: To study the metabolic parameters which may affect the excessive weight of treated and untreated patients with Laron Syndrome.
  • SUBJECTS: Nine untreated adult subjects with Laron Syndrome (6 female subjects, 3 male subjects) aged 28-53 years and 4 girls with Laron Syndrome treated by insulin-like growth factor-I (IGF-I) 120-150 μg/kg/d were included in the study.

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  • [Copyright] © 2009 Asian Oceanian Association for the Study of Obesity . Published by Elsevier Ltd. All rights reserved.
  • (PMID = 24345535.001).
  • [ISSN] 1871-403X
  • [Journal-full-title] Obesity research & clinical practice
  • [ISO-abbreviation] Obes Res Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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23. Dhanwal DK, Vyas A, Sharma A, Saxena A: Hypothalamic pituitary abnormalities in tubercular meningitis at the time of diagnosis. Pituitary; 2010 Dec;13(4):304-10
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  • This prospective study included 75 untreated adult patients with TBM diagnosed as "definite", "highly probable" and "probable" TBM by Ahuja's criteria and in clinical stage 1, 2 or 3 at the time of presentation to hospital.
  • [MeSH-minor] Adolescent. Adult. Female. Follicle Stimulating Hormone / blood. Humans. Hydrocortisone / blood. Luteinizing Hormone / blood. Magnetic Resonance Imaging. Male. Prolactin / blood. Thyrotropin / blood. Thyroxine / blood. Triiodothyronine / blood. Young Adult

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  • (PMID = 20495961.001).
  • [ISSN] 1573-7403
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 06LU7C9H1V / Triiodothyronine; 9002-62-4 / Prolactin; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine; WI4X0X7BPJ / Hydrocortisone
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24. Wiśniewski A, Milde K, Stupnicki R: [Spontaneous growth of girls with Turner's syndrome until 6 years of age]. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw; 2006;12(1):7-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A marked short stature is a prime symptom of the disease, the average adult body height of untreated women being by 23 cm lower than that of healthy ones.
  • At the age of 6 years, the average difference in body height between Turner and healthy girls exceeds 1/3 of the final growth deficit noted in untreated adult women with TS.

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  • (PMID = 16704855.001).
  • [ISSN] 1234-625X
  • [Journal-full-title] Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologów Dziecięcych
  • [ISO-abbreviation] Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
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25. Goodman DW: The consequences of attention-deficit/hyperactivity disorder in adults. J Psychiatr Pract; 2007 Sep;13(5):318-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although treatments are available for adult ADHD, many patients never receive an accurate diagnosis that would afford them appropriate therapeutic intervention.
  • If left untreated, adult ADHD can cause significant personal, social, and economic burdens that can have a negative impact on overall quality of life.
  • [MeSH-minor] Achievement. Adult. Age Factors. Amphetamine / therapeutic use. Atomoxetine Hydrochloride. Cognitive Therapy. Combined Modality Therapy. Comorbidity. Disease Progression. Female. Health Care Costs. Humans. Impulsive Behavior / diagnosis. Impulsive Behavior / psychology. Male. Mental Disorders / diagnosis. Mental Disorders / drug therapy. Mental Disorders / epidemiology. Methylphenidate / therapeutic use. Propylamines / therapeutic use. Quality of Life. Sex Distribution. Social Adjustment. Substance-Related Disorders / diagnosis. Substance-Related Disorders / epidemiology. Substance-Related Disorders / psychology

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  • (PMID = 17890980.001).
  • [ISSN] 1527-4160
  • [Journal-full-title] Journal of psychiatric practice
  • [ISO-abbreviation] J Psychiatr Pract
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Propylamines; 207ZZ9QZ49 / Methylphenidate; 57WVB6I2W0 / Atomoxetine Hydrochloride; CK833KGX7E / Amphetamine
  • [Number-of-references] 74
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26. Lam LT: Uncorrected or untreated vision problems and occupational injuries among the adolescent and adult population in Australia. Inj Prev; 2008 Dec;14(6):396-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uncorrected or untreated vision problems and occupational injuries among the adolescent and adult population in Australia.
  • OBJECTIVE: To investigate the relationship between uncorrected or untreated vision problems and occupational injuries in the adolescent and adult population in Australia.
  • Exposure measures: Information on uncorrected or untreated vision problems was collected by personal interview via responses to screening questions.
  • RESULTS: After adjustment for potential confounders, the odds of occupational injury increased by approximately 60% (OR = 1.57, 95% CI = 1.11 to 2.24) for those who had any uncorrected or untreated vision problems, and by 3(1/2) times (OR = 3.52, 95% CI = 1.64 to 7.55) for those with untreated macular degeneration compared with healthy subjects.
  • CONCLUSIONS: Uncorrected or untreated vision problems, particularly macular degeneration, significantly increased the risk of occupational injury.
  • [MeSH-minor] Adolescent. Adult. Australia / epidemiology. Female. Health Surveys. Humans. Male. Middle Aged. Risk Factors. Socioeconomic Factors. Young Adult


27. Montalto M, Santoro L, Curigliano V, D'Onofrio F, Cammarota G, Panunzi S, Ricci R, Gallo A, Grieco A, Gasbarrini A, Gasbarrini G: Faecal calprotectin concentrations in untreated coeliac patients. Scand J Gastroenterol; 2007 Aug;42(8):957-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Faecal calprotectin concentrations in untreated coeliac patients.
  • The purpose of this pilot study was to evaluate FCCs in untreated coeliac patients and to correlate them with clinical score and histological characteristics.
  • Thirty healthy adult volunteers participated as the control group.
  • RESULTS: FCCs in untreated coeliac patients were not significantly different from those in controls (p=0.163).
  • CONCLUSIONS: This study shows, for the first time, that FCCs in untreated coeliac patients do not differ significantly from those in controls.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Pilot Projects

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  • (PMID = 17613925.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Leukocyte L1 Antigen Complex
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28. Carli L, Montecucco C, Rossetto O: Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg. Muscle Nerve; 2009 Sep;40(3):374-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • N-CAM is a membrane glycoprotein that accumulates on muscle fibers after denervation and is not expressed in untreated adult muscle.

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  • (PMID = 19618426.001).
  • [ISSN] 0148-639X
  • [Journal-full-title] Muscle & nerve
  • [ISO-abbreviation] Muscle Nerve
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP06133
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecules; 0 / Neuromuscular Agents; EC 3.4.24.69 / Botulinum Toxins, Type A
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29. Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM: MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood; 2008 Mar 15;111(6):3183-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.
  • To determine whether miRNAs are associated with cytogenetic abnormalities and clinical features in acute myeloid leukemia (AML), we evaluated the miRNA expression of CD34(+) cells and 122 untreated adult AML cases using a microarray platform.
  • An independent set of 60 untreated AML patients was used to validate the outcome signatures using real-time polymerase chain reaction.

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  • (PMID = 18187662.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA16058; United States / NCI NIH HHS / CA / P01CA76259; United States / NCI NIH HHS / CA / P01 CA081534; United States / NCI NIH HHS / CA / P01 CA076259; United States / NCI NIH HHS / CA / P01CA81534; United States / NCI NIH HHS / CA / P30 CA016058; United States / NCI NIH HHS / CA / P01 CA055164
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / MicroRNAs
  • [Other-IDs] NLM/ PMC2265455
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30. Taricco LD, Aoki SS: Rehabilitation of an adult patient with arthrogryposis multiplex congenita treated with an external fixator. Am J Phys Med Rehabil; 2009 May;88(5):431-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rehabilitation of an adult patient with arthrogryposis multiplex congenita treated with an external fixator.
  • Reports that describe the experience of a rehabilitation program for adult patients with arthrogryposis are rare.
  • We describe the treatment of an adult patient who had not received previous surgery or rehabilitation.
  • This report aims to emphasize the good result of interdisciplinary care of a previously untreated adult patient with arthrogryposis.

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  • (PMID = 19620956.001).
  • [ISSN] 1537-7385
  • [Journal-full-title] American journal of physical medicine & rehabilitation
  • [ISO-abbreviation] Am J Phys Med Rehabil
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Churchwell MI, Beland FA, Doerge DR: Quantification of O6-methyl and O6-ethyl deoxyguanosine adducts in C57BL/6N/Tk+/- mice using LC/MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci; 2006 Nov 21;844(1):60-6
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  • This sensitivity permitted evaluation of adduct levels in livers from separate groups of untreated adult C57BL/6N/Tk(+/-) and C57BL/6N X Sv129 mice (undetectable to 5.5+/-6.7 O(6)Me-dG/10(8) nucleotides; undetectable to 0.04 O(6)Et-dG/10(8) nucleotides).
  • Treatment of adult C57BL/6N/Tk(+/-) mice with equimolar doses (342micromol/kg body weight) of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea produced adduct levels in liver of 1700+/-80 O(6)Me-dG/10(8) nucleotides and 260+/-60 O(6)Et-dG/10(8) nucleotides, respectively, when assessed 4h after dosing.

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  • (PMID = 16931193.001).
  • [ISSN] 1570-0232
  • [Journal-full-title] Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • [ISO-abbreviation] J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 50704-46-6 / O(6)-ethyl-2'-deoxyguanosine; 964-21-6 / O(6)-methyl-2'-deoxyguanosine; G9481N71RO / Deoxyguanosine
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32. Ueyama C, Akashiba H, Nakayama K, Nakayama KI, Nishiyama N, Matsuki N: Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration. Neuroreport; 2007 Nov 19;18(17):1781-5
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  • No change was observed in hippocampal cell viability in untreated adult p27 heterozygous and homozygous mice compared with wild type (+/+).

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  • (PMID = 18090311.001).
  • [ISSN] 0959-4965
  • [Journal-full-title] Neuroreport
  • [ISO-abbreviation] Neuroreport
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Excitatory Amino Acid Agonists; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; 9007-49-2 / DNA; SIV03811UC / Kainic Acid
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33. Olsvik PA, Lie KK, Jordal AE, Nilsen TO, Hordvik I: Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon. BMC Mol Biol; 2005;6:21
The Lens. Cited by Patents in .

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  • The relative transcription levels of genes encoding 18S rRNA, S20 ribosomal protein, beta-actin, glyceraldehyde-3P-dehydrogenase (GAPDH), and two paralog genes encoding elongation factor 1A (EF1AA and EF1AB) were quantified in gills, liver, head kidney, spleen, thymus, brain, muscle, and posterior intestine in six untreated adult fish, in addition to a group of individuals that went through smoltification.
  • Based on calculations performed with the geNorm VBA applet, which determines the most stable genes from a set of tested genes in a given cDNA sample, the ranking of the examined genes in adult Atlantic salmon was EF1AB>EF1AA>beta-actin>18S rRNA>S20>GAPDH.

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  • [Cites] Anal Biochem. 2001 Dec 1;299(1):63-70 [11726185.001]
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  • (PMID = 16293192.001).
  • [ISSN] 1471-2199
  • [Journal-full-title] BMC molecular biology
  • [ISO-abbreviation] BMC Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Actins; 0 / Peptide Elongation Factor 1; 0 / RNA, Ribosomal, 18S; 0 / Ribosomal Proteins; 0 / ribosomal protein S20; EC 1.2.1.- / Glyceraldehyde-3-Phosphate Dehydrogenases
  • [Other-IDs] NLM/ PMC1314898
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34. Zuidam JM, de Kraker M, Selles RW, Hovius SE: Evaluation of function and appearance of adults with untreated triphalangeal thumbs. J Hand Surg Am; 2010 Jul;35(7):1146-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of function and appearance of adults with untreated triphalangeal thumbs.
  • Therefore, a population with an untreated triphalangeal thumb is still present.
  • The purpose of this study is to compare function and appearance of adults with an untreated triphalangeal thumb to a normal population.
  • METHODS: Twelve adults with 23 hands with an untreated triphalangeal thumb, unilateral or bilateral, were examined using objective measurements (thumb movement, joint instability, pain, and strength) and subjective measurements (visual analog scale; Disabilities of the Arm, Shoulder, and Hand questionnaire; and Short Form 36 health survey).
  • CONCLUSIONS: The examined group of adults with an untreated triphalangeal thumb had adequate thumb movement.
  • This indicates that the main impact of an untreated triphalangeal thumb in daily functioning might not be the diminished function but rather the dissimilar appearance.
  • [MeSH-minor] Adult. Cohort Studies. Congenital Abnormalities / diagnosis. Disability Evaluation. Female. Humans. Male. Middle Aged. Pain Measurement. Reference Values. Surveys and Questionnaires

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  • [Copyright] Copyright 2010. Published by Elsevier Inc.
  • [CommentIn] J Hand Surg Am. 2011 Feb;36(2):368-9; author reply 369 [21276906.001]
  • (PMID = 20561755.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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35. Luzzati F, De Marchis S, Fasolo A, Peretto P: Neurogenesis in the caudate nucleus of the adult rabbit. J Neurosci; 2006 Jan 11;26(2):609-21
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  • [Title] Neurogenesis in the caudate nucleus of the adult rabbit.
  • Stem cells with the potential to give rise to new neurons reside in different regions of the adult rodents CNS, but in vivo only the hippocampal dentate gyrus and the subventricular zone-olfactory bulb system are neurogenic under physiological condition.
  • Accordingly, we have demonstrated recently that, in the adult rabbit brain, striking structural plasticity persists in several cortical and subcortical areas.
  • Here, by using markers for immature and mature neuronal and glial cell types, endogenous and exogenously administered cell-proliferation markers, intraventricular cell tracer injections coupled to confocal analysis, three-dimensional reconstructions, and in vitro tissue cultures, we demonstrate the existence of newly formed neurons in the caudate nucleus of normal, untreated, adult rabbit.

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  • (PMID = 16407559.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Calbindin 2; 0 / Fluoresceins; 0 / Fluorescent Dyes; 0 / Nerve Tissue Proteins; 0 / S100 Calcium Binding Protein G; 136832-63-8 / 5-chloromethylfluorescein
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36. Wang M, Giralt S, Delasalle K, Handy B, Alexanian R: Bortezomib in combination with thalidomide-dexamethasone for previously untreated multiple myeloma. Hematology; 2007 Jun;12(3):235-9
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  • [Title] Bortezomib in combination with thalidomide-dexamethasone for previously untreated multiple myeloma.
  • In a previous trial among 137 previously untreated patients with multiple myeloma, the combination of thalidomide-dexamethasone induced remission in 66% of patients, including complete remission in 13%.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Bortezomib. Dexamethasone / administration & dosage. Hematopoietic Stem Cell Transplantation. Humans. Melphalan / therapeutic use. Middle Aged. Remission Induction. Thalidomide / administration & dosage. Transplantation, Autologous. Treatment Outcome

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  • (PMID = 17558699.001).
  • [ISSN] 1607-8454
  • [Journal-full-title] Hematology (Amsterdam, Netherlands)
  • [ISO-abbreviation] Hematology
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Boronic Acids; 0 / Pyrazines; 4Z8R6ORS6L / Thalidomide; 69G8BD63PP / Bortezomib; 7S5I7G3JQL / Dexamethasone; Q41OR9510P / Melphalan
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37. Lappin JM, Morgan K, Morgan C, Hutchison G, Chitnis X, Suckling J, Fearon P, McGuire PK, Jones PB, Leff J, Murray RM, Dazzan P: Gray matter abnormalities associated with duration of untreated psychosis. Schizophr Res; 2006 Apr;83(2-3):145-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gray matter abnormalities associated with duration of untreated psychosis.
  • PURPOSE: A long duration of untreated psychosis (DUP) is associated with relatively poor clinical and social outcomes.
  • [MeSH-minor] Adolescent. Adult. Aged. Brain Mapping. Female. Humans. Image Processing, Computer-Assisted. Magnetic Resonance Imaging / methods. Male. Mental Status Schedule. Middle Aged. Retrospective Studies. Time Factors

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  • (PMID = 16448803.001).
  • [ISSN] 0920-9964
  • [Journal-full-title] Schizophrenia research
  • [ISO-abbreviation] Schizophr. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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38. Laron Z, Ginsberg S, Webb M: Nonalcoholic fatty liver in patients with Laron syndrome and GH gene deletion - preliminary report. Growth Horm IGF Res; 2008 Oct;18(5):434-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SUBJECTS: We studied 11 untreated adult patients with LS (5M, 6F), five girls with LS treated by IGF-I and five adult patients with GH gene deletion (3M, 3F), four previously treated by hGH in childhood.
  • RESULTS: Six out of 11 adult patients with LS, two out of the five IGF-I treated girls with LS and three out of five adult hGH gene deletion patients were found to have NAFLD (nonalcoholic fatty liver disease).
  • CONCLUSION: NAFLD is a frequent complication in untreated and treated congenital IGF-I deficiency.
  • [MeSH-minor] Adult. Female. Humans. Insulin Resistance. Insulin-Like Growth Factor I / deficiency. Male. Middle Aged

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  • (PMID = 18462969.001).
  • [ISSN] 1096-6374
  • [Journal-full-title] Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • [ISO-abbreviation] Growth Horm. IGF Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone; 67763-96-6 / Insulin-Like Growth Factor I
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39. Rakusan D, Kujal P, Kramer HJ, Husková Z, Vanourková Z, Vernerová Z, Mrázová I, Thumová M, Cervenka L, Vanecková I: Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats. Am J Physiol Renal Physiol; 2010 Oct;299(4):F758-66
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  • The effects of the human renin inhibitor aliskiren on blood pressure (BP), end-organ damage, proteinuria, and tissue and plasma angiotensin (ANG) II levels in young and adult heterozygous Ren-2 transgenic rats (TGR) were evaluated and compared with the effect of the ANG type 1 (AT(1)) receptor blocker losartan during treatment and after 12 days after the withdrawal of drug treatments.
  • BP was monitored by telemetry from the age of 32 days on (young rats) and at 100 days (adult rats).
  • Aliskiren (10 mg·kg(-1)·day(-1) in osmotic minipumps) or losartan (5 mg·kg(-1)·day(-1) in drinking water) treatment was applied for 28 days in young rats and for 70 days in adult rats.
  • In young untreated TGR, severe hypertension rapidly evolved.
  • Adult untreated TGR exhibited stable established hypertension.
  • Both aliskiren and losartan fully prevented the development of hypertension and cardiac hypertrophy in young TGR and normalized BP and cardiac hypertrophy in adult TGR.
  • After cessation of aliskiren treatment in both young and adult TGR BP and cardiac hypertrophy were persistently reduced, while after losartan withdrawal BP and cardiac hypertrophy rapidly increased.
  • In adult aliskiren-treated rats proteinuria was significantly reduced compared with losartan (the effect persisting after withdrawal of treatment), and this decrease strongly correlated with normalization of glomerular size in these animals.

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  • (PMID = 20668096.001).
  • [ISSN] 1522-1466
  • [Journal-full-title] American journal of physiology. Renal physiology
  • [ISO-abbreviation] Am. J. Physiol. Renal Physiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amides; 0 / Antihypertensive Agents; 0 / Fumarates; 0 / Ren2 protein, rat; 11128-99-7 / Angiotensin II; 502FWN4Q32 / aliskiren; EC 3.4.23.15 / Renin; JMS50MPO89 / Losartan
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40. Li LP, Shiao AS, Chen LF, Niddam DM, Chang SY, Lien CF, Lee SK, Hsieh JC: Healthy-side dominance of middle- and long-latency neuromagnetic fields in idiopathic sudden sensorineural hearing loss. Eur J Neurosci; 2006 Aug;24(3):937-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The present study used magnetoencephalography to investigate auditory-evoked magnetic fields [a component of the middle-latency auditory evoked fields peaking at approximately 50 ms (P50m) and a component of the long-latency auditory evoked fields peaking at approximately 100 ms (N100m)] on stimulation of both healthy and affected ears in patients with acute unilateral idiopathic sudden sensorineural hearing loss (ISSNHL) of moderate degree in order to elucidate the functional plasticity of the auditory system.
  • Sixteen right-handed, previously untreated adult patients with acute unilateral left (n = 8) or right (n = 8) ISSNHL of moderate degree were studied.
  • [MeSH-minor] Acoustic Stimulation. Adult. Evoked Potentials, Auditory / physiology. Female. Humans. Magnetoencephalography. Male. Middle Aged. Reaction Time / physiology

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  • (PMID = 16930421.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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41. Knuchel MC, Tomasik Z, Speck RF, Lüthy R, Schüpbach J: Ultrasensitive quantitative HIV-1 p24 antigen assay adapted to dried plasma spots to improve treatment monitoring in low-resource settings. J Clin Virol; 2006 May;36(1):64-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • STUDY DESIGN: DPS from 47 HIV-seropositive, treated or untreated adult individuals and 30 healthy individuals were examined.
  • [MeSH-minor] Adult. Anti-HIV Agents / therapeutic use. Case-Control Studies. Child. Costs and Cost Analysis. Enzyme-Linked Immunosorbent Assay. Evaluation Studies as Topic. HIV Antibodies / blood. HIV Antibodies / chemistry. HIV Antigens / blood. HIV Seropositivity. Hot Temperature. Humans. Protein Denaturation. Sensitivity and Specificity. Treatment Outcome. Viral Load

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  • (PMID = 16431154.001).
  • [ISSN] 1386-6532
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / HIV Antibodies; 0 / HIV Antigens; 0 / HIV Core Protein p24
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42. Winquist E, Knox J, Ayoub JP, Wood L, Wainman N, Reid GK, Pearce L, Shah A, Eisenhauer E: Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study. Invest New Drugs; 2006 Mar;24(2):159-67
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  • Untreated adult patients with measurable MRC were treated with MG98 at a dose of 360 mg/m2 via 2-h iv infusion twice weekly for three consecutive weeks out of four.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Canada. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. RNA, Messenger / blood

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  • (PMID = 16502349.001).
  • [ISSN] 0167-6997
  • [Journal-full-title] Investigational new drugs
  • [ISO-abbreviation] Invest New Drugs
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / DMAP1 protein, human; 0 / MG 98 phosphorothioate antisense oligodeoxynucleotide; 0 / Oligodeoxyribonucleotides; 0 / RNA, Messenger; 0 / Repressor Proteins; 0 / Thionucleotides
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43. Huang SC, Kuo KN: Relationship of anatomic classifications to degenerative changes in untreated developmental dysplasia of the hip. J Formos Med Assoc; 2005 May;104(5):349-53
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  • [Title] Relationship of anatomic classifications to degenerative changes in untreated developmental dysplasia of the hip.
  • BACKGROUND AND PURPOSE: In untreated developmental dysplasia of the hip (DDH), degenerative changes of the femoral heads develop mainly in hips with pseudoacetabular formation.
  • METHODS: Twenty five consecutive patients with untreated DDH who underwent open reduction and reconstructive surgery between 1982 and 2001 were included in this retrospective analysis.
  • CONCLUSION: Degenerative change of the femoral heads can develop in untreated dislocated hips of patients with skeletally mature DDH regardless the height of dislocation and pseudoacetabular formation.

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  • (PMID = 15959602.001).
  • [ISSN] 0929-6646
  • [Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi
  • [ISO-abbreviation] J. Formos. Med. Assoc.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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44. Shahin D, Eltoraby E, Mesbah A, Houssen M: Insulin resistance in early untreated rheumatoid arthritis patients. Clin Biochem; 2010 May;43(7-8):661-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Insulin resistance in early untreated rheumatoid arthritis patients.
  • OBJECTIVES: To assess insulin resistance in early untreated rheumatoid arthritis patients and its relation to the clinical, inflammatory and biochemical characteristics of these patients.
  • PATIENTS AND METHODS: Sixty-six untreated rheumatoid arthritis (RA) patients with disease duration less than 1 year along with age and sex matched controls were studied.
  • CONCLUSION: The findings of the present study showed that early untreated RA patients are characterized by a severe insulin resistant state that is driven primarily by disease activity and systemic inflammation.
  • [MeSH-minor] Adult. Blood Glucose / metabolism. C-Reactive Protein / metabolism. Female. Humans. Insulin / blood. Lipids / blood. Male. Middle Aged

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  • [Copyright] 2010. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20144599.001).
  • [ISSN] 1873-2933
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Insulin; 0 / Lipids; 9007-41-4 / C-Reactive Protein
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45. Zaja F, Baccarani M, Mazza P, Bocchia M, Gugliotta L, Zaccaria A, Vianelli N, Defina M, Tieghi A, Amadori S, Campagna S, Ferrara F, Angelucci E, Usala E, Cantoni S, Visani G, Fornaro A, Rizzi R, De Stefano V, Casulli F, Battista ML, Isola M, Soldano F, Gamba E, Fanin R: Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia. Blood; 2010 Apr 8;115(14):2755-62
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  • This randomized trial investigated rituximab efficacy in previously untreated adult ITP patients with a platelet count of 20 x 10(9)/L or less.
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal, Murine-Derived. Female. Humans. Male. Middle Aged. Platelet Count. Rituximab. Time Factors


46. Gutiérrez LP, Kołtowska-Häggström M, Jönsson PJ, Mattsson AF, Svensson D, Westberg B, Luger A: Registries as a tool in evidence-based medicine: example of KIMS (Pfizer International Metabolic Database). Pharmacoepidemiol Drug Saf; 2008 Jan;17(1):90-102
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  • The study was based on 11,374 treated (40,000 patient-years of observation) and 263 untreated adult GH deficient patients from 30 countries, in whom background characteristics, clinical values such as lipids and body composition, quality of life (QoL) and GH dosage as well as safety profile were evaluated.
  • RESULTS: The study depicts the clinical picture of adult patients with GH deficiency managed in current clinical settings.
  • [MeSH-minor] Adult. Body Composition / drug effects. Cholesterol / blood. Evidence-Based Medicine. Female. Humans. Male. Prospective Studies. Quality of Life. Recombinant Proteins. Treatment Outcome

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  • (PMID = 17957812.001).
  • [ISSN] 1053-8569
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Recombinant Proteins; 12629-01-5 / Human Growth Hormone; 97C5T2UQ7J / Cholesterol
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47. Hamurcu Z, Dönmez-Altuntas H, Patiroglu T: Basal level micronucleus frequency in stimulated lymphocytes of untreated patients with leukemia. Cancer Genet Cytogenet; 2008 Jan 15;180(2):140-4
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  • [Title] Basal level micronucleus frequency in stimulated lymphocytes of untreated patients with leukemia.
  • Structural chromosomal aberrations have been described in various types of human leukemia.
  • The present study investigated micronucleus (MN) frequency in mitogen-stimulated peripheral blood lymphocytes from 20 newly diagnosed and untreated leukemia patients: 4 with acute lymphoblastic leukemia (ALL), 10 with acute myeloid leukemia (AML), and 6 with chronic lymphocytic leukemia (CLL).
  • The mean MN frequency for untreated patients was 3.65 +/- 1.47 in ALL, 3.55 +/- 1.24 in AML, 3.03 +/- 1.05 in CLL.
  • No differences in MN frequency were seen between leukemia types ALL, AML, and CLL (P = 0.503).
  • The mean basal MN frequency for all patients, regardless of leukemia type, was 3.41 +/- 1.19, which was significantly higher (P = 0.001) than that of 20 age-matched control subjects, 1.87 +/- 0.75.
  • Although no significant relationship was found between age and MN frequency in patients with leukemia (r = 0.050; P = 0.835), the MN frequency in the lymphocytes of healthy control increased regularly and significantly with age (r = 0.531; P = 0.016).
  • These data indicate that the increased baseline MN frequency in lymphocytes of untreated patients with leukemia may reflect genomic instability or deficiency of DNA repair capacity.
  • [MeSH-major] Leukemia / genetics. Lymphocytes / metabolism. Micronuclei, Chromosome-Defective / statistics & numerical data
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Case-Control Studies. Child. Child, Preschool. Female. Humans. Male. Micronucleus Tests. Middle Aged

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  • (PMID = 18206540.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Burnett J, Coverdale JH, Pickens S, Dyer CB: What is the association between self-neglect, depressive symptoms and untreated medical conditions? J Elder Abuse Negl; 2006;18(4):25-34
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  • [Title] What is the association between self-neglect, depressive symptoms and untreated medical conditions?
  • OBJECTIVE: There have been no studies describing the occurrence of untreated medical condition(s) in elders with depression who self-neglect.
  • It also describes the relationship between untreated medical condition(s) associated with self-neglect and abnormal scores on the GDS-SF.
  • METHODS: The two samples consisted of 50 self-neglect cases validated by Adult Protective Services and 50 matched non-self-neglecters recruited from a hospital geriatric unit.
  • Untreated medical condition(s) was determined during the assessment by a geriatric nurse practitioner.
  • Self-neglecters with scores indicative of depression were also significantly more likely (56% vs. 21%) to have untreated medical condition(s) compared to self-neglecters scoring normal on the GDS-SF (OR = 4.84, 95% CI = 1.37-17.09).
  • CONCLUSION: Clinicians should anticipate untreated medical condition(s) in elderly patients with depressive symptomatology who self-neglect.

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  • (PMID = 17972657.001).
  • [ISSN] 0894-6566
  • [Journal-full-title] Journal of elder abuse & neglect
  • [ISO-abbreviation] J Elder Abuse Negl
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20RR20626
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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49. Ozminkowski RJ, Wang S, Walsh JK: The direct and indirect costs of untreated insomnia in adults in the United States. Sleep; 2007 Mar;30(3):263-73
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  • [Title] The direct and indirect costs of untreated insomnia in adults in the United States.
  • OBJECTIVES: To estimate the direct and indirect cost burden of untreated insomnia among younger adults (age 18-64), and to estimate the direct costs of untreated insomnia for elderly patients (age 65 and over).
  • [MeSH-minor] Absenteeism. Adolescent. Adult. Aged. Case-Control Studies. Costs and Cost Analysis. Drug Costs / statistics & numerical data. Female. Humans. Hypnotics and Sedatives / economics. Hypnotics and Sedatives / therapeutic use. Male. Middle Aged. Retrospective Studies. Sick Leave / economics. United States

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  • (PMID = 17425222.001).
  • [ISSN] 0161-8105
  • [Journal-full-title] Sleep
  • [ISO-abbreviation] Sleep
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives
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50. Morita Y, Kanamaru A, Miyazaki Y, Imanishi D, Yagasaki F, Tanimoto M, Kuriyama K, Kobayashi T, Imoto S, Ohnishi K, Naoe T, Ohno R: Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group. Int J Hematol; 2010 Jan;91(1):97-103
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  • [Title] Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group.
  • A total of 120 patients with high-risk myelodysplastic syndrome (MDS) and AML progressed from MDS (MDS-AML) were registered in a randomized controlled study of the Japan Adult Leukemia Study Group (JALSG).
  • Untreated adult patients with high-risk MDS and MDS-AML were randomly assigned to receive either idarubicin and cytosine arabinoside (IDR/Ara-C) (Group A) or low-dose cytosine arabinoside and aclarubicin (CA) (Group B).
  • [MeSH-major] Aclarubicin / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Cytarabine / administration & dosage. Idarubicin / administration & dosage. Leukemia, Myeloid, Acute / drug therapy. Myelodysplastic Syndromes / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / administration & dosage. Antimetabolites, Antineoplastic / administration & dosage. Female. Humans. Japan. Male. Middle Aged. Remission Induction. Risk Factors. Survival Analysis. Treatment Outcome. Young Adult

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  • (PMID = 20047095.001).
  • [ISSN] 1865-3774
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Antimetabolites, Antineoplastic; 04079A1RDZ / Cytarabine; 74KXF8I502 / Aclarubicin; ZRP63D75JW / Idarubicin
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51. McKenzie EJ, Taylor PR, Stillion RJ, Lucas AD, Harris J, Gordon S, Martinez-Pomares L: Mannose receptor expression and function define a new population of murine dendritic cells. J Immunol; 2007 Apr 15;178(8):4975-83
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  • We have now observed that while MR(+) cells are consistently absent from T cell areas of spleen and mesenteric lymph nodes (LN), peripheral LN of untreated adult mice contain a minor population of MR(+)MHCII(+) in the paracortex.

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  • (PMID = 17404279.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 0 / Lectins, C-Type; 0 / Lipopolysaccharides; 0 / Mannose-Binding Lectins; 0 / Receptors, Cell Surface; 0 / mannose receptor
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52. Lifschitz A, Virkel G, Ballent M, Sallovitz J, Pis A, Lanusse C: Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents. J Vet Pharmacol Ther; 2005 Oct;28(5):411-8

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  • Both compounds were incubated under anaerobic conditions during 2, 6 and 24 h in ruminal and abomasal contents collected from untreated adult sheep.
  • Neither MXD nor IVM suffered metabolic conversion and/or chemical degradation after 24-h incubation in ruminal and abomasal contents collected from adult sheep.

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  • (PMID = 16207302.001).
  • [ISSN] 0140-7783
  • [Journal-full-title] Journal of veterinary pharmacology and therapeutics
  • [ISO-abbreviation] J. Vet. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anthelmintics; 0 / Macrolides; 51570-36-6 / milbemycin; 70288-86-7 / Ivermectin
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53. Dillo W, Göke A, Prox-Vagedes V, Szycik GR, Roy M, Donnerstag F, Emrich HM, Ohlmeier MD: Neuronal correlates of ADHD in adults with evidence for compensation strategies--a functional MRI study with a Go/No-Go paradigm. Ger Med Sci; 2010;8:Doc09
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  • METHODS: fMRI was used to compare brain activation in 15 untreated adult patients with ADHD and 15 healthy reference volunteers during performance of a Go/No-Go task.
  • CONCLUSION: We hypothesize that the enhanced activity is due to the ability of adult ADHD patients to compensate their deficits for a short time, which is demonstrated in our study by equal task performance in both groups.
  • [MeSH-minor] Adaptation, Physiological / physiology. Adult. Female. Frontal Lobe / physiopathology. Gyrus Cinguli / physiopathology. Humans. Male. Parietal Lobe / physiopathology. Psychomotor Performance. Young Adult

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  • (PMID = 20421953.001).
  • [ISSN] 1612-3174
  • [Journal-full-title] German medical science : GMS e-journal
  • [ISO-abbreviation] Ger Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2858877
  • [Keywords] NOTNLM ; ADHD / Go/No-Go task / fMRI / neuronal compensation
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54. Tektas OY, Hammer CM, Danias J, Candia O, Gerometta R, Podos SM, Lütjen-Drecoll E: Morphologic changes in the outflow pathways of bovine eyes treated with corticosteroids. Invest Ophthalmol Vis Sci; 2010 Aug;51(8):4060-6
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  • METHODS: The TM of four adult Braford cow eyes treated with 0.5% prednisolone eye drops three times daily for 7 weeks and their contralateral eyes treated with artificial tear preparation and that of two adult untreated Braford cows and untreated young calves eyes were analyzed with light and electron microscopy.
  • In the untreated Braford controls and in untreated calf eyes, plaques were nearly absent.
  • These changes were not seen in contralateral eyes or eyes of untreated animals.

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  • (PMID = 20237246.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY13749; United States / NEI NIH HHS / EY / R01 EY013749; United States / NEI NIH HHS / EY / R03 EY016050; United States / NEI NIH HHS / EY / R01 EY000160; United States / NEI NIH HHS / EY / EY00160; United States / NEI NIH HHS / EY / EY016050
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type VI; 0 / Glucocorticoids; 9PHQ9Y1OLM / Prednisolone
  • [Other-IDs] NLM/ PMC2910640
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55. Silbergeld A, Lilos P, Laron Z: Foot length before and during insulin-like growth factor-I treatment of children with laron syndrome compared to human growth hormone treatment of children with isolated growth hormone deficiency. J Pediatr Endocrinol Metab; 2007 Dec;20(12):1325-8
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  • Fifteen non-treated adult patients with LS were also included in the study.
  • METHODS: Measurements of foot length were recorded without treatment and monitored during 9 years of treatment in the children and in the untreated adult patients.
  • Adult foot size of untreated patients with LS is small but less retarded than the height deficit.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Body Height / drug effects. Child. Female. Hormone Replacement Therapy / methods. Humans. Male. Time Factors. Treatment Outcome

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  • (PMID = 18341092.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 67763-96-6 / Insulin-Like Growth Factor I; 9002-72-6 / Growth Hormone
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56. Holsberger DR, Kiesewetter SE, Cooke PS: Regulation of neonatal Sertoli cell development by thyroid hormone receptor alpha1. Biol Reprod; 2005 Sep;73(3):396-403
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  • Neonatal hypothyroidism increases adult Sertoli cell populations by extending Sertoli cell proliferation.
  • Triiodothyronine (T3) treatment from birth until Postnatal Day 10 reduced Sertoli cell proliferation to minimal levels in WT and TRbetaKO mice versus that in their untreated controls, whereas T3 had a diminished effect on TRalphaKO Sertoli cell proliferation.
  • In untreated adult TRalphaKO mice, Sertoli cell number, testis weight, and daily sperm production were increased or trended toward an increase, but the increase in magnitude was smaller than that seen in WT mice following neonatal hypothyroidism.
  • Conversely, in TRbetaKO mice, Sertoli cell number, testis weight, and daily sperm production were similar to those in untreated WT mice.
  • In addition, Sertoli cell number and testis weight in adult WT and TRbetaKO mice showed comparable increases following hypothyroidism.

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  • (PMID = 15858214.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / C06 RR16515; United States / NIEHS NIH HHS / ES / ES11590; United States / NICHD NIH HHS / HD / T32 HD07028
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cdkn1b protein, mouse; 0 / Cell Cycle Proteins; 0 / Thyroid Hormone Receptors alpha; 0 / Tumor Suppressor Proteins; 06LU7C9H1V / Triiodothyronine; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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57. Avilés A, Nambo MJ, Neri N, Castañeda C, Cleto S, Huerta-Guzmán J: Antitumor effect of zoledronic acid in previously untreated patients with multiple myeloma. Med Oncol; 2007;24(2):227-30
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  • [Title] Antitumor effect of zoledronic acid in previously untreated patients with multiple myeloma.
  • Ninety four patients with previously untreated multiple myeloma were treated with a conventional chemotherapy program: cyclophosphamide, vincristine, melphalan, and prednisone (CVMP) and were randomized to received either zoledronic acid (4 mg, iv, every 28 d) or not (control group).
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17848748.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Diphosphonates; 0 / Imidazoles; 6XC1PAD3KF / zoledronic acid
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58. Moll C, Bogas M, Gómez-Puerta JA, Celis R, Vázquez I, Rodríguez F, Kanterewicz E, Sanmarti R, Cañete JD: Macroscopic features of knee synovitis in early untreated Behçet disease and psoriatic arthritis. Clin Rheumatol; 2009 Sep;28(9):1053-7
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  • [Title] Macroscopic features of knee synovitis in early untreated Behçet disease and psoriatic arthritis.
  • The objective of this study is to describe the macroscopic features of early untreated knee synovitis in BD and PsA.
  • Video-recording of 35 early untreated arthritis patients with different diagnoses were also studied looking for BD-like macroscopic features.
  • None of the 35 patients with early untreated arthritis exhibited all the characteristic features of BD synovitis.
  • [MeSH-minor] Adult. Arthroscopy. Capillaries / pathology. Early Diagnosis. Female. Fibrosis. Humans. Hyperemia / pathology. Male. Middle Aged. Video Recording. Young Adult


59. Santarelli L, Gabrielli M, Santoliquido A, Cuoco L, Cazzato A, Candelli M, Celestino Nista E, De Lorenzo A, Gentiloni Silveri N, Pola P, Gasbarrini G, Gasbarrini A: Interaction between Helicobacter pylori infection and untreated coeliac disease on gastric histological pattern. Scand J Gastroenterol; 2006 May;41(5):532-5
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  • [Title] Interaction between Helicobacter pylori infection and untreated coeliac disease on gastric histological pattern.
  • The aim of this study was to assess the gastric histological pattern in patients with H. pylori and untreated coeliac disease.
  • MATERIAL AND METHODS: We retrospectively enrolled 183 H. pylori-positive patients with (85, group A) and without (98, group B) untreated coeliac disease.
  • CONCLUSIONS: In patients with H. pylori infection, untreated coeliac disease could represent a risk factor for follicular gastritis and is associated with a lower prevalence of atrophic gastritis.
  • The complex interaction between H. pylori and untreated coeliac disease on Th-1/Th-2 balance in the gastric mucosa could explain these results.
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Retrospective Studies. Smoking

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  • (PMID = 16638694.001).
  • [ISSN] 0036-5521
  • [Journal-full-title] Scandinavian journal of gastroenterology
  • [ISO-abbreviation] Scand. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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60. Goossens K, Juniarto AZ, Timmerman MA, Faradz SM, Wolffenbuttel KP, Drop SL, de Jong FH: Lack of correlation between phenotype and genotype in untreated 21-hydroxylase-deficient Indonesian patients. Clin Endocrinol (Oxf); 2009 Nov;71(5):628-35

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  • [Title] Lack of correlation between phenotype and genotype in untreated 21-hydroxylase-deficient Indonesian patients.
  • OBJECTIVE: To assess the correlation between genotype and phenotype in untreated patients with 21-hydroxylase deficiency.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Clitoris / anatomy & histology. Clitoris / pathology. DNA Mutational Analysis. Female. Gene Frequency. Genotype. Humans. Indonesia. Infant. Karyotyping. Male. Polymerase Chain Reaction. Virilism / genetics. Virilism / pathology. Young Adult

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  • (PMID = 19226270.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.99.10 / CYP21A2 protein, human; EC 1.14.99.10 / Steroid 21-Hydroxylase
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61. Venkitaraman R, Norman A, Woode-Amissah R, Dearnaley D, Horwich A, Huddart R, Parker C: Prostate-specific antigen velocity in untreated, localized prostate cancer. BJU Int; 2008 Jan;101(2):161-4
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  • [Title] Prostate-specific antigen velocity in untreated, localized prostate cancer.
  • OBJECTIVE: To report the results of a prospective study of active surveillance of untreated prostate cancer, with a focus on baseline predictors of prostate-specific antigen (PSA) velocity, as PSA velocity before treatment is an important predictor of prostate cancer mortality, and patients on active surveillance are monitored for several years to estimate the PSA velocity and thus select patients for radical treatment.
  • CONCLUSIONS: PSA density, which is readily available at the time of diagnosis, is an independent determinant of PSA velocity in untreated, localized prostate cancer.
  • [MeSH-minor] Adult. Aged. Biopsy, Needle. Choice Behavior. Cohort Studies. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Staging / methods. Prospective Studies. Prostatectomy / methods. Risk Factors


62. Petersen KL, Bleil ME, McCaffery J, Mackey RH, Sutton-Tyrrell K, Muldoon MF, Manuck SB: Community socioeconomic status is associated with carotid artery atherosclerosis in untreated, hypertensive men. Am J Hypertens; 2006 Jun;19(6):560-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Community socioeconomic status is associated with carotid artery atherosclerosis in untreated, hypertensive men.
  • METHODS: Subjects were 230 untreated hypertensive men without history of coronary heart disease, residing in and around Pittsburgh, PA (80% white, 20% African-American; mean age, 56 years).
  • CONCLUSIONS: Irrespective of one's own income or educational attainment, untreated hypertensive men living in poorer communities are more likely to exhibit preclinical atherosclerosis than residents of more affluent areas.
  • [MeSH-minor] Adult. Aged. Blood Pressure. Carotid Arteries / ultrasonography. Humans. Male. Middle Aged. Risk Factors. Social Class. Tunica Intima / ultrasonography. Tunica Media / ultrasonography

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  • (PMID = 16733226.001).
  • [ISSN] 0895-7061
  • [Journal-full-title] American journal of hypertension
  • [ISO-abbreviation] Am. J. Hypertens.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL 40962
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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63. Law CW, Chen EY, Cheung EF, Chan RC, Wong JG, Lam CL, Leung KF, Lo MS: Impact of untreated psychosis on quality of life in patients with first-episode schizophrenia. Qual Life Res; 2005 Oct;14(8):1803-11
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  • [Title] Impact of untreated psychosis on quality of life in patients with first-episode schizophrenia.
  • Despite increasing interest in the quality of life (QOL) of psychiatric patients in recent years, few studies have focused on the potential adverse effects of the illness on QOL during the period of untreated psychosis.
  • Young patients with first-episode schizophrenia have poorer QOL in the period of untreated psychosis than their counterparts in the community.
  • [MeSH-minor] Adolescent. Adult. Data Collection. Female. Hong Kong. Humans. Male

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  • (PMID = 16155768.001).
  • [ISSN] 0962-9343
  • [Journal-full-title] Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
  • [ISO-abbreviation] Qual Life Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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64. Qin YZ, Li JL, Zhu HH, Li LD, Chang Y, Le H, Ruan GR, Liu YR, Huang XJ, Chen SS: [Detection of common fusion transcript levels in untreated leukemia patients by real-time quantitative RT-PCR technique]. Zhonghua Xue Ye Xue Za Zhi; 2007 Jul;28(7):433-7
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  • [Title] [Detection of common fusion transcript levels in untreated leukemia patients by real-time quantitative RT-PCR technique].
  • OBJECTIVE: To evaluate levels of common specific fusion transcripts M-bcr-abl, m-bcr-abl, TEL-AML1, AML1-ETO, PML-RAR alpha, CBF beta-MYH11 in untreated leukemia patients.
  • METHODS: Specific fusion transcript levels were detected by TaqMan-based real-time quantitative RT-PCR technique in a total of 208 samples, including 195 bone marrow samples from 50 M-bcr-abl(+) chronic phase-chronic myeloid leukemia (CML-CP), 10 M-bcr-abl(+) acute lymphoblastic leukemia (ALL), 19 m-bcr-abl(+) ALL, 11 TEL-AML1(+) ALL, 30 AML1-ETO(+) acute myeloid leukemia (AML), 58 PML-RAR alpha(+) acute promyelocytic leukemia (APL) and 17 CBF beta-MYH11(+) AML patients and 13 peripheral blood samples from 13 M-bcr-abl(+) CML-CP patients. abl was chosen as internal control gene.
  • CONCLUSIONS: Fusion transcript levels in untreated leukemia patients were different and patient-to-patient variations did exist.
  • Detection of fusion transcript levels in untreated leukemia patients not only provides baseline for minimal residual disease monitoring and treatment evaluation but also enable the comparison in inter-laboratory data.
  • [MeSH-major] Leukemia / genetics. Oncogene Proteins, Fusion / genetics. Reverse Transcriptase Polymerase Chain Reaction / methods
  • [MeSH-minor] Adolescent. Adult. Bone Marrow Cells / metabolism. Child. Child, Preschool. Core Binding Factor Alpha 2 Subunit / genetics. Female. Fusion Proteins, bcr-abl / genetics. Humans. Male. Middle Aged. Transcription, Genetic

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  • (PMID = 18072623.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / AML1-ETO fusion protein, human; 0 / CBFbeta-MYH11 fusion protein; 0 / Core Binding Factor Alpha 2 Subunit; 0 / Oncogene Proteins, Fusion; 0 / TEL-AML1 fusion protein; 0 / promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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65. Nordentoft M, Thorup A, Petersen L, Øhlenschlaeger J, Christensen TØ, Krarup G, Jørgensen P, Jeppesen P: Does a detection team shorten duration of untreated psychosis? Early Interv Psychiatry; 2008 Feb;2(1):22-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Does a detection team shorten duration of untreated psychosis?
  • INTRODUCTION: Duration of untreated psychosis (DUP) is shown to be associated with poor outcome in many domains.
  • [MeSH-minor] Adolescent. Adult. Early Diagnosis. Health Services Accessibility / statistics & numerical data. Humans. Middle Aged. Referral and Consultation / statistics & numerical data. Schizotypal Personality Disorder / diagnosis. Schizotypal Personality Disorder / therapy. Time Factors

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  • [Copyright] © 2008 The Authors.
  • (PMID = 21352127.001).
  • [ISSN] 1751-7893
  • [Journal-full-title] Early intervention in psychiatry
  • [ISO-abbreviation] Early Interv Psychiatry
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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66. Compton MT, Ramsay CE, Shim RS, Goulding SM, Gordon TL, Weiss PS, Druss BG: Health services determinants of the duration of untreated psychosis among African-American first-episode patients. Psychiatr Serv; 2009 Nov;60(11):1489-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Health services determinants of the duration of untreated psychosis among African-American first-episode patients.
  • OBJECTIVE: The duration of untreated psychosis is associated with poor outcomes in multiple domains in the early course of nonaffective psychotic disorders, although relatively little is known about determinants of this critical period, particularly health services-level determinants.
  • This study examined three hypothesized predictors of duration of untreated psychosis (lack of insurance, financial problems, and broader barriers) among urban, socioeconomically disadvantaged African Americans, while controlling for the effects of three patient-level predictors (mode of onset of psychosis, living with family versus alone or with others before hospitalization, and living above versus below the federally defined poverty level).
  • The duration of untreated psychosis and all other variables were measured in a rigorous, standardized fashion in a study designed specifically to examine determinants of treatment delay.
  • RESULTS: The median duration of untreated psychosis was 24.5 weeks.
  • When the analyses controlled for the three patient-level covariates, patients without health insurance, with financial problems, or with barriers to seeking help had a significantly longer duration of untreated psychosis.
  • [MeSH-minor] Early Diagnosis. Female. Humans. Insurance, Health. Kaplan-Meier Estimate. Male. Medically Uninsured / statistics & numerical data. Middle Aged. Poverty / statistics & numerical data. Proportional Hazards Models. Socioeconomic Factors. Time Factors. Young Adult

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  • (PMID = 19880467.001).
  • [ISSN] 1557-9700
  • [Journal-full-title] Psychiatric services (Washington, D.C.)
  • [ISO-abbreviation] Psychiatr Serv
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / K23 MH067589; United States / NIMHD NIH HHS / MD / U54 MD007588
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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67. Radvar M, Mardani N, Mellati E, Habibi M: Improvement of periodontal parameters in untreated quadrants after surgical periodontal therapy at adjacent quadrants. J Periodontol; 2009 Apr;80(4):565-71
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  • [Title] Improvement of periodontal parameters in untreated quadrants after surgical periodontal therapy at adjacent quadrants.
  • The aim of this study was to find out whether surgical treatments performed on each quadrant would have any influence on the periodontal status of the untreated quadrants.
  • [MeSH-minor] Adult. Dental Scaling. Female. Humans. Male. Middle Aged. Periodontal Attachment Loss / surgery. Periodontal Index. Treatment Outcome

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  • (PMID = 19335075.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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68. Yeung YP, Lo CM, Liu CL, Wong BC, Fan ST, Wong J: Natural history of untreated nonsurgical hepatocellular carcinoma. Am J Gastroenterol; 2005 Sep;100(9):1995-2004
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history of untreated nonsurgical hepatocellular carcinoma.
  • We studied the natural history of untreated nonsurgical HCC to examine whether the prognosis has changed with improved supportive treatment and to identify factors affecting survival.
  • CONCLUSIONS: The prognosis of untreated HCC not suitable for curative treatment in Asia is grave despite improved supportive treatment.
  • [MeSH-minor] Adult. Aged. China. Disease Progression. Female. Follow-Up Studies. Hepatitis B Surface Antigens / analysis. Hong Kong / epidemiology. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 16128944.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hepatitis B Surface Antigens
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69. Pawlowski AP, Chen A, Hacker BM, Mancl LA, Page RC, Roberts FA: Clinical effects of scaling and root planing on untreated teeth. J Clin Periodontol; 2005 Jan;32(1):21-8
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  • [Title] Clinical effects of scaling and root planing on untreated teeth.
  • OBJECTIVE: The aim of this report is to examine whether scaling and root planing (SRP) in one area of the mouth may affect periodontal improvement in untreated areas in the same patient, possibly through systemic effects of treatment.
  • Within the treatment group, three quadrants were treated by SRP at week 0, 3, 12, and 24, while a single experimental quadrant remained untreated throughout the study.
  • In untreated sites within treated subjects, however, PDs tended to improve (p=0.09) but at a reduced rate compared with treated sites.
  • The levels of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis (Bacteroides forsythus) remained unchanged in untreated sites while levels of Prevetolla intermedia and Treponema denticola tended to decrease as compared with controls but did not reach significance.
  • CONCLUSIONS: This study indicates that untreated sites in treated periodontitis patients show a trend towards clinical improvement and exhibit reductions in some but not all periodontopathic bacterial species tested.
  • [MeSH-minor] Adolescent. Adult. Colony Count, Microbial / trends. Dental Plaque / microbiology. Dental Plaque Index. Female. Humans. Male. Treatment Outcome

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  • [Copyright] Copyright Blackwell Munksgaard, 2004.
  • (PMID = 15642054.001).
  • [ISSN] 0303-6979
  • [Journal-full-title] Journal of clinical periodontology
  • [ISO-abbreviation] J. Clin. Periodontol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE-00431; United States / NIDCR NIH HHS / DE / DE-08555; United States / NIDCR NIH HHS / DE / DE-12939
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Denmark
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70. Martin WR, Wieler M, Stoessl AJ, Schulzer M: Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease. Ann Neurol; 2008 Mar;63(3):388-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease.
  • OBJECTIVE: To determine the sensitivity of positron emission tomography with 11C-labeled dihydrotetrabenazine (DTBZ) to the nigrostriatal changes associated with early, untreated Parkinson's disease (PD), and to determine the correlation between any regionally reduced DTBZ binding and the major motor features of PD.
  • METHODS: Untreated patients with early PD (n = 27) and age-matched control subjects (n = 33) underwent DTBZ/positron emission tomography scanning to measure binding to the presynaptic type 2 vesicular monoamine transporter site in dopaminergic neurons in basal ganglia regions.
  • [MeSH-minor] Adult. Aged. Corpus Striatum / metabolism. Corpus Striatum / radionuclide imaging. Cross-Sectional Studies. Early Diagnosis. Female. Humans. Male. Middle Aged. Protein Binding / physiology

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  • (PMID = 18240153.001).
  • [ISSN] 1531-8249
  • [Journal-full-title] Annals of neurology
  • [ISO-abbreviation] Ann. Neurol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 3466-75-9 / dihydrotetrabenazine; Z9O08YRN8O / Tetrabenazine
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71. Foley SR, Browne S, Clarke M, Kinsella A, Larkin C, O'Callaghan E: Is violence at presentation by patients with first-episode psychosis associated with duration of untreated psychosis? Soc Psychiatry Psychiatr Epidemiol; 2007 Aug;42(8):606-10
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  • [Title] Is violence at presentation by patients with first-episode psychosis associated with duration of untreated psychosis?
  • Duration of untreated psychosis (DUP) has been shown to influence psychopathology at presentation in first-episode psychosis, but little is known about the direct relationship between violence at presentation and DUP.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Psychiatric Status Rating Scales / statistics & numerical data. Psychopathology / methods. Retrospective Studies. Schizophrenia / diagnosis. Schizophrenic Psychology. Time Factors

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  • (PMID = 17598060.001).
  • [ISSN] 0933-7954
  • [Journal-full-title] Social psychiatry and psychiatric epidemiology
  • [ISO-abbreviation] Soc Psychiatry Psychiatr Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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72. Allan CM, Garcia A, Spaliviero J, Jimenez M, Handelsman DJ: Maintenance of spermatogenesis by the activated human (Asp567Gly) FSH receptor during testicular regression due to hormonal withdrawal. Biol Reprod; 2006 May;74(5):938-44
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  • Testes of untreated adult Tg-FSHR* males were equivalent in weight to nontransgenic controls but exhibited increased total Sertoli cell (24%) and spermatogonia (34%) numbers and nonsignificantly elevated spermatocyte-spermatid numbers (13%-17%).
  • After 6 wk of T withdrawal, spermatogonia, spermatocyte, and postmeiotic spermatid numbers in Tg-FSHR* Gnrh1(-/-) testes decreased to levels found in untreated Tg-FSHR* Gnrh1(-/-) testes.
  • Basal serum T levels in untreated Tg-FSHR* Gnrh1(-/-) males were 2-fold higher than Gnrh1(-/-) controls, but following T treatment/withdrawal, serum T and epididymal weights declined to basal levels found in nontransgenic Gnrh1(-/-) mice.

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  • [ErratumIn] Biol Reprod. 2006 Jun;74(6):1121. Handelsman, David J [added]
  • (PMID = 16452461.001).
  • [ISSN] 0006-3363
  • [Journal-full-title] Biology of reproduction
  • [ISO-abbreviation] Biol. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / Gonadotropins; 0 / Receptors, FSH; 30KYC7MIAI / Aspartic Acid; 33515-09-2 / Gonadotropin-Releasing Hormone; TE7660XO1C / Glycine
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73. Morgan C, Abdul-Al R, Lappin JM, Jones P, Fearon P, Leese M, Croudace T, Morgan K, Dazzan P, Craig T, Leff J, Murray R, AESOP Study Group: Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study. Br J Psychiatry; 2006 Nov;189:446-52
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  • [Title] Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study.
  • BACKGROUND: Despite considerable research investigating the relationship between a long duration of untreated psychosis (DUP) and outcomes, there has been much less considering predictors of a long DUP.
  • RESULTS: An insidious mode of onset was associated with a substantially longer DUP compared with an acute onset, independent of other factors.
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Mental Health Services. Middle Aged. Schizophrenic Psychology

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  • (PMID = 17077436.001).
  • [ISSN] 0007-1250
  • [Journal-full-title] The British journal of psychiatry : the journal of mental science
  • [ISO-abbreviation] Br J Psychiatry
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G0600972
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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74. Morgan C, Fearon P, Hutchinson G, McKenzie K, Lappin JM, Abdul-Al R, Morgan K, Dazzan P, Boydell J, Harrison G, Craig T, Leff J, Jones P, Murray R, AESOP Study Group: Duration of untreated psychosis and ethnicity in the AESOP first-onset psychosis study. Psychol Med; 2006 Feb;36(2):239-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duration of untreated psychosis and ethnicity in the AESOP first-onset psychosis study.
  • Data relating to duration of untreated psychosis (DUP) and clinical and sociodemographic characteristics were collected from patients, relatives and case-notes.
  • RESULTS: There was no evidence that African-Caribbean or Black African patients experienced longer periods of untreated psychosis than White British patients prior to first contact with services.
  • There was evidence that Black African patients experienced shorter periods of untreated psychosis than White British patients.
  • [MeSH-minor] Adolescent. Adult. African Continental Ancestry Group / ethnology. Aged. England / epidemiology. European Continental Ancestry Group / ethnology. Female. Humans. Male. Middle Aged. Referral and Consultation. Time Factors. West Indies / ethnology

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  • (PMID = 16318656.001).
  • [ISSN] 0033-2917
  • [Journal-full-title] Psychological medicine
  • [ISO-abbreviation] Psychol Med
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G106/1148
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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75. Schillaci G, Pirro M, Vaudo G, Mannarino MR, Savarese G, Pucci G, Franklin SS, Mannarino E: Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension. Hypertension; 2005 Jun;45(6):1078-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension.
  • We conclude that in untreated hypertension, the metabolic syndrome is independently associated with a higher aortic, but not upper limb, pulse wave velocity.
  • [MeSH-minor] Abdomen. Adult. Aging. Anthropometry. Blood Flow Velocity. Blood Pressure. Blood Pressure Monitoring, Ambulatory. Case-Control Studies. Compliance. Diastole. Female. Humans. Male. Middle Aged. Prognosis. Pulse. Systole

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  • (PMID = 15867139.001).
  • [ISSN] 1524-4563
  • [Journal-full-title] Hypertension (Dallas, Tex. : 1979)
  • [ISO-abbreviation] Hypertension
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. N'Dri-Yoman T, Anglaret X, Messou E, Attia A, Polneau S, Toni T, Chenal H, Seyler C, Gabillard D, Wakasugi N, Eholié S, Danel C: Occult HBV infection in untreated HIV-infected adults in Côte d'Ivoire. Antivir Ther; 2010;15(7):1029-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occult HBV infection in untreated HIV-infected adults in Côte d'Ivoire.
  • Here, we estimated the prevalence of untreated HIV-infected adults with negative serum HBsAg and detectable plasma HBV DNA in Côte d'Ivoire.
  • We tested all untreated HIV type-1 (HIV-1)-infected adults with CD4(+) T-cell counts <500 cells/mm(3) for HBsAg, hepatitis B core antibodies (anti-HBc) and HBsAg antibodies (anti-HBs).
  • [MeSH-minor] Adenine / analogs & derivatives. Adenine / therapeutic use. Adult. Aged. Antiretroviral Therapy, Highly Active / adverse effects. CD4 Lymphocyte Count. Cote d'Ivoire / epidemiology. Cross-Sectional Studies. Deoxycytidine / analogs & derivatives. Deoxycytidine / therapeutic use. Emtricitabine. Female. Hepatitis B Antibodies / blood. Hepatitis B Antibodies / immunology. Hepatitis B Core Antigens / blood. Hepatitis B Core Antigens / immunology. Hepatitis B Surface Antigens / blood. Hepatitis B Surface Antigens / immunology. Humans. Lamivudine / therapeutic use. Male. Middle Aged. Organophosphonates / therapeutic use. Prevalence. Tenofovir. World Health Organization. Young Adult

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  • (PMID = 21041918.001).
  • [ISSN] 2040-2058
  • [Journal-full-title] Antiviral therapy
  • [ISO-abbreviation] Antivir. Ther. (Lond.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Hepatitis B Antibodies; 0 / Hepatitis B Core Antigens; 0 / Hepatitis B Surface Antigens; 0 / Organophosphonates; 0W860991D6 / Deoxycytidine; 2T8Q726O95 / Lamivudine; 99YXE507IL / Tenofovir; G70B4ETF4S / Emtricitabine; JAC85A2161 / Adenine
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77. Quaranta L, Konstas AG, Rossetti L, Garcia-Feijoo J, O'Brien C, Nasr MB, Fogagnolo P, Demos CM, Stewart JA, Stewart WC: Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry. Eye (Lond); 2010 Jul;24(7):1252-8
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry.
  • METHODS: A prospective, untreated, uncontrolled, observational cohort of qualified consecutive ocular hypertensive or primary open-angle glaucoma patients.
  • CONCLUSION: This study suggests that with Perkins applanation tonometry the untreated mean supine intraocular pressures are not higher at night than daytime sitting Goldmann applanation tonometry.
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Glaucoma / diagnosis. Glaucoma / physiopathology. Humans. Male. Middle Aged. Prospective Studies. Supine Position

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  • [CommentIn] Eye (Lond). 2010 Sep;24(9):1530-1; author reply 1531-2 [20523362.001]
  • (PMID = 19960033.001).
  • [ISSN] 1476-5454
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Lima CS, Zantut Wittmann DE, Castro V, Tambascia MA, Lorand-Metze I, Saad ST, Costa FF: Pancytopenia in untreated patients with Graves' disease. Thyroid; 2006 Apr;16(4):403-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pancytopenia in untreated patients with Graves' disease.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Methimazole / therapeutic use

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  • (PMID = 16646688.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 554Z48XN5E / Methimazole
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79. Pöpperl G, Kreth FW, Mehrkens JH, Herms J, Seelos K, Koch W, Gildehaus FJ, Kretzschmar HA, Tonn JC, Tatsch K: FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading. Eur J Nucl Med Mol Imaging; 2007 Dec;34(12):1933-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FET PET for the evaluation of untreated gliomas: correlation of FET uptake and uptake kinetics with tumour grading.
  • The aim of the study was to evaluate the potential of [(18)F]fluoroethyltyrosine (FET) PET for non-invasive tumour grading in untreated patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Metabolic Clearance Rate. Middle Aged. Neoplasm Staging. Radiopharmaceuticals / pharmacokinetics. Reproducibility of Results. Sensitivity and Specificity. Statistics as Topic

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  • (PMID = 17763848.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / O-(2-fluoroethyl)tyrosine; 0 / Radiopharmaceuticals; 42HK56048U / Tyrosine
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80. Li ZF, Guo ZF, Yang SG, Zheng X, Cao J, Qin YW: Circulating ghrelin and ghrelin to obestatin ratio are low in patients with untreated mild-to-moderate hypertension. Regul Pept; 2010 Dec 10;165(2-3):206-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating ghrelin and ghrelin to obestatin ratio are low in patients with untreated mild-to-moderate hypertension.
  • We investigated fasting plasma ghrelin and obestatin levels and ratio of ghrelin to obestatin in humans with untreated mild-to-moderate hypertension and humans with normal blood pressure.
  • [MeSH-minor] Adult. Anthropometry. Fasting / blood. Humans. Male

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20688108.001).
  • [ISSN] 1873-1686
  • [Journal-full-title] Regulatory peptides
  • [ISO-abbreviation] Regul. Pept.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Ghrelin
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81. López NJ, Socransky SS, Da Silva I, Japlit MR, Haffajee AD: Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. J Clin Periodontol; 2006 Sep;33(9):648-60
Hazardous Substances Data Bank. METRONIDAZOLE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis.
  • MATERIAL AND METHODS: Twenty-two patients with untreated chronic periodontitis were randomly assigned to a group that received M+A for 7 days, or to a group receiving scaling and root planing (SRP) and two placebos.
  • [MeSH-minor] Adult. Aged. Bacteria / classification. Bacteria / drug effects. Case-Control Studies. Chronic Disease. Dental Plaque / microbiology. Dental Plaque / therapy. Dental Scaling. Drug Combinations. Female. Follow-Up Studies. Gingival Hemorrhage / therapy. Humans. Male. Middle Aged. Patient Compliance. Periodontal Attachment Loss / therapy. Periodontal Pocket / therapy. Placebos. Root Planing. Smoking

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  • [CommentIn] J Clin Periodontol. 2006 Dec;33(12):938-9; author reply 940-1 [17092246.001]
  • [CommentIn] J Clin Periodontol. 2006 Dec;33(12):936-7; author reply 940-1 [17092245.001]
  • [CommentIn] J Clin Periodontol. 2006 Sep;33(9):661-2 [16918990.001]
  • (PMID = 16856904.001).
  • [ISSN] 0303-6979
  • [Journal-full-title] Journal of clinical periodontology
  • [ISO-abbreviation] J. Clin. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Infective Agents; 0 / Drug Combinations; 0 / Placebos; 140QMO216E / Metronidazole; 804826J2HU / Amoxicillin
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82. Esteves SC, Oliveira FV, Bertolla RP: Clinical outcome of intracytoplasmic sperm injection in infertile men with treated and untreated clinical varicocele. J Urol; 2010 Oct;184(4):1442-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical outcome of intracytoplasmic sperm injection in infertile men with treated and untreated clinical varicocele.
  • Of the men 80 underwent prior subinguinal microsurgical varicocelectomy (treated group 1) and 162 had any grade of clinical varicocele (untreated group 2) at sperm injection.
  • The clinical pregnancy (60.0% vs 45.0%, p = 0.04) and live birth (46.2% vs 31.4%, p = 0.03) rates after the sperm injection procedure were higher in the treated than in the untreated group.
  • [MeSH-minor] Adult. Female. Humans. Male. Pregnancy / statistics & numerical data

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  • [Copyright] Copyright © 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20727535.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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83. De Marinis E, Martini C, Trentalance A, Pallottini V: Sex differences in hepatic regulation of cholesterol homeostasis. J Endocrinol; 2008 Sep;198(3):635-43
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  • Our data support that physiological differences in proteins involved in cholesterol balance are present between the sexes and, in particular, 3-hydroxy 3-methylglutaryl coenzyme A reductase shows lower activity and expression in female and 17-beta-estradiol-treated male rats than in adult untreated male.

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  • (PMID = 18603607.001).
  • [ISSN] 1479-6805
  • [Journal-full-title] The Journal of endocrinology
  • [ISO-abbreviation] J. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Insig1 protein, rat; 0 / Membrane Proteins; 0 / Sterol Regulatory Element Binding Protein 2; 4TI98Z838E / Estradiol; 97C5T2UQ7J / Cholesterol; EC 1.1.1.- / Hydroxymethylglutaryl CoA Reductases
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84. Dogan EA, Usta BE, Bilgen R, Senol Y, Aktekin B: Efficacy, tolerability, and side effects of oxcarbazepine monotherapy: a prospective study in adult and elderly patients with newly diagnosed partial epilepsy. Epilepsy Behav; 2008 Jul;13(1):156-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy, tolerability, and side effects of oxcarbazepine monotherapy: a prospective study in adult and elderly patients with newly diagnosed partial epilepsy.
  • OBJECTIVE: The aim of the study described here was to investigate the efficacy, tolerability, and side effects of oxcarbazepine (OXC) monotherapy in newly diagnosed, previously untreated adult and elderly patients with partial epilepsy.
  • CONCLUSION: Although the limitations of our study include its open-label design, the results suggest that OXC monotherapy may be regarded as an effective first-line monotherapy option for adult and elderly patients with partial epilepsy, but has low efficacy in patients with cerebral tumors.
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Drug Evaluation. Female. Humans. Male. Middle Aged. Prospective Studies. Retrospective Studies

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  • (PMID = 18331816.001).
  • [ISSN] 1525-5069
  • [Journal-full-title] Epilepsy & behavior : E&B
  • [ISO-abbreviation] Epilepsy Behav
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 33CM23913M / Carbamazepine; VZI5B1W380 / oxcarbazepine
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85. Mazziotti G, Bianchi A, Bonadonna S, Nuzzo M, Cimino V, Fusco A, De Marinis L, Giustina A: Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy. J Bone Miner Res; 2006 Apr;21(4):520-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy.
  • This cross-sectional study shows that a high number of untreated adult patients with GHD develop radiological vertebral deformities.
  • MATERIALS AND METHODS: One hundred seven adult hypopituitary patients (67 males and 40 females; mean age, 47 years; range: 16-81 years) with severe GHD and 130 control subjects (39 males, 91 females; mean age: 58.9 years; range: 26-82 years) were evaluated for BMD (DXA) and vertebral deformities (quantitative morphometric analysis).
  • The fracture prevalence, as well as the fracture number, was significantly higher in untreated versus treated patients (78.6% versus 53.8%; chi2: 6.7; p = 0.009), although the two groups of patients did not show any significant difference in median T score.
  • In untreated GHD patients, the prevalence of vertebral deformities was correlated with T score (p = 0.002) and duration of disease (p = 0.003).
  • CONCLUSIONS: This cross-sectional study reports high prevalence of vertebral radiological deformities in adult patients with untreated GHD.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bone Density / physiology. Cross-Sectional Studies. Female. Fractures, Bone / epidemiology. Humans. Male. Middle Aged. Prevalence. Risk Factors

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  • (PMID = 16598371.001).
  • [ISSN] 0884-0431
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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86. Rödel S, Engert A, Diehl V, Reiser M: Combination chemotherapy with adriamycin, cyclophosphamide, vincristine, methotrexate, etoposide and dexamethasone (ACOMED) followed by involved field radiotherapy induces high remission rates and durable long-term survival in patients with aggressive malignant non-Hodgkin's lymphomas: long-term follow-up of a pilot study. Leuk Lymphoma; 2005 Dec;46(12):1729-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Untreated adult patients with aggressive NHL, presenting with Ann Arbour stage II-IV disease or stage I with bulky disease, and with at least one of the following risk factors: age > 60 years, advanced disease, elevated serum lactate dehydrogenase level, Eastern Cooperative Oncology Group (ECOG) performance status >or= 2, presence of extranodal sites of disease and bulky disease, were treated with the ACOMED regimen consisting of 4-6 cycles of adriamycin 25 mg/m(2) i.v. on days 4-5, cyclophosphamide 250 mg/m(2) i.v. on days 1-5, vincristine 2 mg i.v. absolute on day 1, methotrexate 500 mg/m(2) i.v. on day 1 with leucovorin-rescue after 24 h 30 mg/m(2) i.v. and 3 x 15 mg p.o., etoposide 100 mg/m(2) i.v. on days 3-5, dexamethasone 10 mg/m(2) p.o. on days 1-5 and granulocyte colony-stimulating factor support, repeated on day 21.
  • [MeSH-minor] Adolescent. Adult. Aged. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Dexamethasone / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Male. Methotrexate / administration & dosage. Middle Aged. Neoplasm Staging. Radiotherapy / adverse effects. Survival Analysis. Survivors. Vincristine / administration & dosage

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  • (PMID = 16353313.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; YL5FZ2Y5U1 / Methotrexate
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87. Suh C, Kang YK, Roh JL, Kim MR, Kim JS, Huh J, Lee JH, Jang YJ, Lee BJ: Prognostic value of tumor 18F-FDG uptake in patients with untreated extranodal natural killer/T-cell lymphomas of the head and neck. J Nucl Med; 2008 Nov;49(11):1783-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic value of tumor 18F-FDG uptake in patients with untreated extranodal natural killer/T-cell lymphomas of the head and neck.
  • METHODS: Pretreatment staging work-ups, including whole-body 18F-FDG PET, were performed on 21 patients with previously untreated head and neck ENKTL.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Positron-Emission Tomography. Prognosis. Survival Rate. Young Adult

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  • (PMID = 18927319.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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88. Krebs MO, Bourdel MC, Cherif ZR, Bouhours P, Lôo H, Poirier MF, Amado I: Deficit of inhibition motor control in untreated patients with schizophrenia: further support from visually guided saccade paradigms. Psychiatry Res; 2010 Oct 30;179(3):279-84
MedlinePlus Health Information. consumer health - Schizophrenia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Deficit of inhibition motor control in untreated patients with schizophrenia: further support from visually guided saccade paradigms.
  • We hypothesized that a deficit in inhibitory control is a core defect in untreated patients with schizophrenia leading to impairment in different oculomotor paradigms.
  • [MeSH-minor] Adult. Eye Movement Measurements. Female. Humans. Male. Multivariate Analysis. Photic Stimulation. Reaction Time / physiology

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  • [Copyright] Copyright © 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20483461.001).
  • [ISSN] 0165-1781
  • [Journal-full-title] Psychiatry research
  • [ISO-abbreviation] Psychiatry Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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89. Corraini P, Baelum V, Pannuti CM, Pustiglioni AN, Romito GA, Pustiglioni FE: Periodontal attachment loss in an untreated isolated population of Brazil. J Periodontol; 2008 Apr;79(4):610-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Periodontal attachment loss in an untreated isolated population of Brazil.
  • BACKGROUND: The aim of this study was to assess the prevalence, extent, and severity of clinical attachment loss (CAL) and to investigate the association of demographic, socioeconomic, and behavioral risk indicators with CAL in an untreated isolated population in Brazil.
  • [MeSH-minor] Adolescent. Adult. Age Factors. Brazil / epidemiology. Child. Dental Calculus / epidemiology. Dental Care / statistics & numerical data. Dental Plaque / epidemiology. Educational Status. Female. Gingival Recession / epidemiology. Humans. Income / statistics & numerical data. Interviews as Topic. Male. Middle Aged. Oral Hygiene / statistics & numerical data. Periodontal Pocket / epidemiology. Physical Examination. Prevalence. Risk Factors. Smoking / epidemiology

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  • (PMID = 18380553.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Huang ZM, Huang QW, Qin YQ, He YZ, Qin HJ, Zhou YN, Xu X, Huang MJ: YMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines. World J Gastroenterol; 2005 Feb 14;11(6):867-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] YMDD mutations in patients with chronic hepatitis B untreated with antiviral medicines.
  • AIM: To polymerase P region (YMDD) mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines and to explore its correlation with pre-c-zone mutations, HBV genotypes and HBV DNA level, and to observe its curative effect.
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Genotype. Hepatitis B e Antigens / genetics. Humans. Male. Middle Aged. Mutation. Treatment Outcome

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  • (PMID = 15682483.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hepatitis B e Antigens; 0 / Reverse Transcriptase Inhibitors; 2T8Q726O95 / Lamivudine
  • [Other-IDs] NLM/ PMC4250599
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91. Danielsson AJ, Hasserius R, Ohlin A, Nachemson AL: Health-related quality of life in untreated versus brace-treated patients with adolescent idiopathic scoliosis: a long-term follow-up. Spine (Phila Pa 1976); 2010 Jan 15;35(2):199-205
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  • [Title] Health-related quality of life in untreated versus brace-treated patients with adolescent idiopathic scoliosis: a long-term follow-up.
  • SUMMARY OF BACKGROUND DATA: Quality of life as measured by the SRS-22 has not previously been presented for adult untreated AIS patients.
  • [MeSH-minor] Activities of Daily Living. Adolescent. Adult. Female. Follow-Up Studies. Health Surveys. Humans. Severity of Illness Index. Spine / radiography. Statistics, Nonparametric. Surveys and Questionnaires. Sweden. Treatment Outcome

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  • (PMID = 20038869.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Obineche E, Abdulle AM, Bokhari AM, Yasin JY, Gillett MP: Circulating levels of endothelin-1 in a homogenous Gulf Arab population with untreated essential hypertension. Ann Saudi Med; 2006 Sep-Oct;26(5):364-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Circulating levels of endothelin-1 in a homogenous Gulf Arab population with untreated essential hypertension.
  • PATIENTS AND METHODS: ET-1 levels were measured in plasma samples from 60 untreated hypertensive Arabs and compared with 60 age- and sex-matched normotensive controls.
  • [MeSH-minor] Adult. Biomarkers / blood. Blood Glucose / metabolism. Blood Pressure. Body Mass Index. Case-Control Studies. Female. Humans. Insulin / blood. Logistic Models. Male. Middle Aged. Multivariate Analysis. Severity of Illness Index. United Arab Emirates / epidemiology

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  • [CommentIn] Ann Saudi Med. 2006 Sep-Oct;26(5):343-5 [17019103.001]
  • (PMID = 17019099.001).
  • [ISSN] 0256-4947
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Blood Glucose; 0 / Endothelin-1; 0 / Insulin
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93. Iovino P, Pascariello A, Limongelli P, Tremolaterra F, Consalvo D, Sabbatini F, Amato G, Ciacci C: The prevalence of sexual behavior disorders in patients with treated and untreated gastroesophageal reflux disease. Surg Endosc; 2007 Jul;21(7):1104-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prevalence of sexual behavior disorders in patients with treated and untreated gastroesophageal reflux disease.
  • RESULTS: Compared with HC, untreated patients with GERD showed more frequent difficulty in attaining orgasm and painful intercourse.
  • When compared with untreated conditions, GERD patients after surgical treatment had a significant improvement in attaining orgasm and in painful intercourse but a significant decrease in sexual desire, a lower satisfaction with their sexual life, and a higher prevalence of an unhelpful partner, whereas GERD patients after medical treatment had a decrease in all indices of sexual behavior.
  • CONCLUSION: Untreated GERD is associated with disorders in sexual behavior.
  • [MeSH-minor] Adult. Age Distribution. Aged. Analysis of Variance. Case-Control Studies. Chronic Disease. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Patient Satisfaction. Probability. Prospective Studies. Risk Assessment. Severity of Illness Index. Sex Distribution. Surveys and Questionnaires

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  • (PMID = 17353980.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Ulcer Agents
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94. Baza Caraciolo B, Pérez de Oteyza C, Carrió Montiel D, Carrió Montiel JC, Salguero Aparicio M, Del Romero Guerrero J: [Lipid profile in untreated HIV positive patients. HIV infection: cardiovascular risk factor?]. An Med Interna; 2007 Apr;24(4):160-7
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  • [Title] [Lipid profile in untreated HIV positive patients. HIV infection: cardiovascular risk factor?].
  • We propose: to describe lipid profile of untreated HIV+ patients and to compare it with the HIV- and to assess whether any of the lipid abnormalities influence in CVR estimation.
  • MATERIAL AND METHODS: 407 homosexual males: 251 untreated HIV+ and 156 HIV-.
  • CONCLUSION: Untreated HIV+ patients' lipid profile is different from the HIV- subjects; one.
  • [MeSH-minor] Adult. CD4 Lymphocyte Count. Cardiovascular Diseases / etiology. Cholesterol / blood. Cholesterol, HDL / blood. Data Interpretation, Statistical. Homosexuality, Male. Humans. Male. Risk Factors. Triglycerides / blood

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  • (PMID = 17867898.001).
  • [ISSN] 0212-7199
  • [Journal-full-title] Anales de medicina interna (Madrid, Spain : 1984)
  • [ISO-abbreviation] An Med Interna
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Cholesterol, HDL; 0 / Lipids; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
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95. Neema M, Navarro-Quiroga I, Chechlacz M, Gilliams-Francis K, Liu J, Lamonica K, Lin SL, Naegele JR: DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. Hippocampus; 2005;15(8):1057-71
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  • Brains from untreated adult heterozygous and DNA-PKcs null mice displayed comparable cytoarchitecture and undetectable levels of cell death.

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16216017.001).
  • [ISSN] 1050-9631
  • [Journal-full-title] Hippocampus
  • [ISO-abbreviation] Hippocampus
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / NS042826-03; United States / NINDS NIH HHS / NS / R01 NS042826; United States / NINDS NIH HHS / NS / R01 NS042826-03; United States / NINDS NIH HHS / NS / R01 NS4286
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzothiazoles; 0 / DNA-Binding Proteins; 0 / Excitatory Amino Acid Agonists; 0 / Nuclear Proteins; 0 / Thiazoles; 0 / Tumor Suppressor Protein p53; 0 / pifithrin; 3FPU23BG52 / Toluene; EC 2.7.11.1 / DNA-Activated Protein Kinase; EC 2.7.11.1 / Prkdc protein, mouse; SIV03811UC / Kainic Acid
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96. Skarbinski J, Massaga JJ, Rowe AK, Kachur SP: Distribution of free untreated bednets bundled with insecticide via an integrated child health campaign in Lindi Region, Tanzania: lessons for future campaigns. Am J Trop Med Hyg; 2007 Jun;76(6):1100-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Distribution of free untreated bednets bundled with insecticide via an integrated child health campaign in Lindi Region, Tanzania: lessons for future campaigns.
  • An integrated child health campaign with free distribution of 162,254 untreated bednets bundled with insecticide, measles vaccination, vitamin A, and mebendazole for children < 5 years old ("under-5s") was conducted in Lindi Region, Tanzania.
  • [MeSH-minor] Adolescent. Adult. Animals. Child, Preschool. Cross-Sectional Studies. Female. Humans. Male. Middle Aged. Pregnancy. Rural Population. Tanzania

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  • (PMID = 17556618.001).
  • [ISSN] 0002-9637
  • [Journal-full-title] The American journal of tropical medicine and hygiene
  • [ISO-abbreviation] Am. J. Trop. Med. Hyg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Insecticides
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97. Teachey DT, Obzut DA, Cooperman J, Fang J, Carroll M, Choi JK, Houghton PJ, Brown VI, Grupp SA: The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood; 2006 Feb 1;107(3):1149-55
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  • [Title] The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL.
  • Acute lymphoblastic leukemia (ALL) in adult patients is often resistant to current therapy, making the development of novel therapeutic agents paramount.
  • Lymphoblasts from adult patients with precursor B ALL were cultured on bone marrow stroma and were treated with CCI-779, a second generation MTI.
  • Treated cells showed a dramatic decrease in cell proliferation and an increase in apoptotic cells, compared to untreated cells.
  • In dramatic contrast, untreated animals continued to show expansion of human ALL.
  • We conclude that MTIs can inhibit the growth of adult human ALL and deserve close examination as therapeutic agents against a disease that is often not curable with current therapy.

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  • (PMID = 16195324.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA98543; United States / NCI NIH HHS / CA / K08 CA104882; United States / NCI NIH HHS / CA / K08 CA104882-01A1; United States / NCI NIH HHS / CA / CA82156; United States / NCI NIH HHS / CA / CA104882-01A1; United States / NCI NIH HHS / CA / CA96696
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 624KN6GM2T / temsirolimus; EC 2.7.- / Protein Kinases; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.1 / mTOR protein, mouse; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC1895910
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98. Oliveira AM, Menezes PR, Busatto GF, McGuire PK, Murray RM, Scazufca M: Family context and duration of untreated psychosis (DUP): results from the Sao Paulo Study. Schizophr Res; 2010 Jun;119(1-3):124-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Family context and duration of untreated psychosis (DUP): results from the Sao Paulo Study.
  • BACKGROUND: Duration of untreated psychosis (DUP) depends on several factors, including socio-demographic, socioeconomic, clinical and contextual circumstances, such as availability of mental health services.
  • Duration of untreated psychosis was defined as the period between onset of first psychotic symptom and first contact with health service due to psychosis.
  • [MeSH-minor] Adult. Awareness. Brazil. Early Diagnosis. Female. Health Services Accessibility. Health Surveys. Humans. Male. Patient Acceptance of Health Care. Psychiatric Status Rating Scales. Social Adjustment. Socioeconomic Factors. Young Adult

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  • [Copyright] Copyright (c) 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19767177.001).
  • [ISSN] 1573-2509
  • [Journal-full-title] Schizophrenia research
  • [ISO-abbreviation] Schizophr. Res.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antipsychotic Agents
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99. Antoniewicz J, Litwin M, Daszkoska J, Niemirska A, Sladowska J, Wierzbicka A, Wawer Z, Grenda R: [Target organ damage in children with newly diagnosed and untreated essential hypertension]. Przegl Lek; 2006;63 Suppl 3:101-6
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  • [Title] [Target organ damage in children with newly diagnosed and untreated essential hypertension].
  • The aim of the study was to determine the prevalence of left ventricular hypertrophy (LVH) and arterial damage and its main determinants in children with newly diagnosed, untreated EH.
  • [MeSH-minor] Adolescent. Adult. Anthropometry. Biomarkers. Body Weights and Measures. Child. Child, Preschool. Cross-Sectional Studies. Female. Humans. Male. Obesity / complications. Reference Values

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  • (PMID = 16898502.001).
  • [ISSN] 0033-2240
  • [Journal-full-title] Przegla̧d lekarski
  • [ISO-abbreviation] Prz. Lek.
  • [Language] pol
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers
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100. Tian M, Zhang H, Higuchi T, Oriuchi N, Nakasone Y, Takata K, Nakajima N, Mogi K, Endo K: Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging. Ann Nucl Med; 2005 Jun;19(4):335-8
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  • [Title] Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging.
  • The aim of this study was to investigate the relationship between HK-II expression and 18F-fluoro-2-deoxy-D-glucose (FDG) uptake in human untreated oral squamous cell carcinoma (OSCC).
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Radiopharmaceuticals / pharmacokinetics. Reproducibility of Results. Sensitivity and Specificity. Statistics as Topic

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  • (PMID = 16097646.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; EC 2.7.1.1 / Hexokinase
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