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Items 1 to 100 of about 2529
1. Yildiz A, Gur M, Demirbag R, Yilmaz R, Akyol S, Aslan M, Erel O: Paraoxonase and arylesterase activities in untreated dipper and non-dipper hypertensive patients. Clin Biochem; 2008 Jul;41(10-11):779-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraoxonase and arylesterase activities in untreated dipper and non-dipper hypertensive patients.
  • [MeSH-minor] Adult. Antioxidants / metabolism. Blood Pressure Monitoring, Ambulatory. Diastole. Female. Heart Rate. Humans. Lipid Peroxides / blood. Male. Middle Aged. Patient Selection. Reference Values. Systole

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  • (PMID = 18355454.001).
  • [ISSN] 1873-2933
  • [Journal-full-title] Clinical biochemistry
  • [ISO-abbreviation] Clin. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Lipid Peroxides; EC 3.1.1.- / Carboxylic Ester Hydrolases; EC 3.1.1.2 / arylesterase; EC 3.1.8.1 / Aryldialkylphosphatase
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2. Saito H, Kudoh S, Nakagawa K, Negoro S, Matsui K, Semba H, Takada M: Phase II study of 3-week scheduling of irinotecan in combination with cisplatin in patients with advanced nonsmall-cell lung cancer. Am J Clin Oncol; 2006 Oct;29(5):503-7
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  • METHODS: Previously untreated patients with stage IIIB and IV NSCLC were treated intravenously with irinotecan (60 mg/m2) on days 1 and 8 and cisplatin (60 mg/m2) on day 1 of a 3-week cycle.
  • [MeSH-minor] Adult. Aged. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Survival Analysis

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  • (PMID = 17023787.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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3. Massé PG, Tranchant CC, Dosy J, Donovan SM: Coexistence of osteoporosis and cardiovascular disease risk factors in apparently healthy, untreated postmenopausal women. Int J Vitam Nutr Res; 2005 Mar;75(2):97-106
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  • [Title] Coexistence of osteoporosis and cardiovascular disease risk factors in apparently healthy, untreated postmenopausal women.
  • This study aimed to determine whether apparently healthy, untreated postmenopausal women at risk of osteoporosis relative to nonmenopausal women are concomitantly at risk of cardiovascular disease (CVD) in terms of various aspects of lifestyle, personality, body shape and composition, and blood chemistry.
  • [MeSH-minor] Adipose Tissue. Adult. Anthropometry. Body Composition. Cross-Sectional Studies. Diet. Exercise. Female. Humans. Insulin-Like Growth Factor I / analysis. Lipids / blood. Middle Aged. Personality. Risk Factors. Skinfold Thickness

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  • (PMID = 15929631.001).
  • [ISSN] 0300-9831
  • [Journal-full-title] International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
  • [ISO-abbreviation] Int J Vitam Nutr Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Lipids; 67763-96-6 / Insulin-Like Growth Factor I
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4. Oliveira-Menezes A, Norões J, Dreyer G, Lanfredi RM: Ultrastructural analysis of Wuchereria bancrofti (Nematoda: Filarioidea) body wall. Micron; 2010 Jul;41(5):526-31
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  • Bancroftian filariasis constitutes the principal mosquito-borne nematode infection of humans and the surface of adult of Wuchereria bancrofti seems to be especially important in the intricate interplay between host and parasite.
  • The study of the parasite's surface structure might help to understand the localization and function of various organelles. W. bancrofti adult worms were recovered from untreated patients during hydrocele repair surgery and studied by transmission electron microscopy.
  • The body wall of adult parasite is composed of cuticle, hypodermis and muscular layer.
  • This is the first study of W. bancrofti adult worms obtained from untreated patients and studied by transmission electron microscopy.
  • [MeSH-minor] Adult. Animal Structures / ultrastructure. Animals. Humans. Male. Microscopy, Electron, Transmission. Skin / ultrastructure. Testicular Hydrocele / parasitology. Testicular Hydrocele / surgery. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20236829.001).
  • [ISSN] 1878-4291
  • [Journal-full-title] Micron (Oxford, England : 1993)
  • [ISO-abbreviation] Micron
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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5. Ascher B: Safety and efficacy of UltraShape Contour I treatments to improve the appearance of body contours: multiple treatments in shorter intervals. Aesthet Surg J; 2010 Mar;30(2):217-24
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  • Untreated thigh areas served as an internal control.
  • Mean thigh circumference (the control area) was unchanged; the relative change between treated and untreated areas of the abdomen was significantly different at all time points.

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  • (PMID = 20442099.001).
  • [ISSN] 1527-330X
  • [Journal-full-title] Aesthetic surgery journal
  • [ISO-abbreviation] Aesthet Surg J
  • [Language] ENG
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] England
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6. Kim GP, Colangelo LH, Wieand HS, Paik S, Kirsch IR, Wolmark N, Allegra CJ, National Cancer Institute: Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. J Clin Oncol; 2007 Mar 1;25(7):767-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PATIENTS AND METHODS: To help define its impact, we conducted an analysis of National Surgical Adjuvant Breast and Bowel Project (NSABP) patients who were randomly assigned to a surgery-alone group (untreated cohort) and patients assigned to an adjuvant fluorouracil (FU) -treated group (treated cohort).
  • Hazard ratios (HR) for RFS for MSI-H versus MSS/MSI-L patients were 0.77 (95% CI, 0.40 to 1.48) in the untreated-patients group and 0.60 (95% CI, 0.30 to 1.19) in the treated-patients group.
  • [MeSH-minor] Adult. Aged. Female. Genes, p53. Humans. Ki-67 Antigen / analysis. Male. Middle Aged. Mutation. Prognosis. Proportional Hazards Models. Protein-Serine-Threonine Kinases. Receptors, Transforming Growth Factor beta / genetics

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  • [CommentIn] J Clin Oncol. 2007 Mar 1;25(7):754-6 [17228016.001]
  • (PMID = 17228023.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P-U10CA-37377; United States / NCI NIH HHS / CA / U10CA-12027; United States / NCI NIH HHS / CA / U10CA-69651; United States / NCI NIH HHS / CA / U10CA-69974
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Receptors, Transforming Growth Factor beta; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.30 / transforming growth factor-beta type II receptor
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7. Vujosevic S, Bottega E, Casciano M, Pilotto E, Convento E, Midena E: Microperimetry and fundus autofluorescence in diabetic macular edema: subthreshold micropulse diode laser versus modified early treatment diabetic retinopathy study laser photocoagulation. Retina; 2010 Jun;30(6):908-16
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  • METHODS: A prospective randomized clinical trial including 62 eyes (50 patients) with untreated, center-involving, clinically significant diabetic macular edema was performed.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Fluorescence. Fundus Oculi. Humans. Male. Middle Aged. Prospective Studies. Retina / physiopathology. Tomography, Optical Coherence. Treatment Outcome. Visual Acuity / physiology. Visual Field Tests

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  • (PMID = 20168272.001).
  • [ISSN] 1539-2864
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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8. Mucha-Pelzer T, Debnath N, Goswami A, Mewis I: Comparison of different silicas of natural origin as possible insecticides. Commun Agric Appl Biol Sci; 2008;73(3):621-8
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  • Untreated insects served as control.
  • For adult Epilachna beetles, we could not detect any differences between the treatments.

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  • (PMID = 19226803.001).
  • [ISSN] 1379-1176
  • [Journal-full-title] Communications in agricultural and applied biological sciences
  • [ISO-abbreviation] Commun. Agric. Appl. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Insecticides; 61790-53-2 / Diatomaceous Earth; 7631-86-9 / Silicon Dioxide
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9. Hile DD, Sonis ST, Doherty SA, Tian X, Zhang Q, Jee WS, Trantolo DJ: Dimensional stability of the alveolar ridge after implantation of a bioabsorbable bone graft substitute: a radiographic and histomorphometric study in rats. J Oral Implantol; 2005;31(2):68-76
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  • The maxillary or mandibular molars on the right side were extracted from 96 adult Sprague-Dawley rats.
  • The defect site was (1) treated with PPF bone repair material containing nanometer-sized HA, (2) treated with PPF material containing micrometer-sized HA, (3) treated with demineralized freeze-dried bone allograft, or (4) left untreated.

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  • (PMID = 15871525.001).
  • [ISSN] 0160-6972
  • [Journal-full-title] The Journal of oral implantology
  • [ISO-abbreviation] J Oral Implantol
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / 1 R43 DE14272
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Polymers; 0 / Propylene Glycols; 0 / poly(propylene glycol-fumarate); 91D9GV0Z28 / Durapatite
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10. Corso A, Mangiacavalli S, Varettoni M, Pascutto C, Zappasodi P, Lazzarino M: Bortezomib-induced peripheral neuropathy in multiple myeloma: a comparison between previously treated and untreated patients. Leuk Res; 2010 Apr;34(4):471-4
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  • [Title] Bortezomib-induced peripheral neuropathy in multiple myeloma: a comparison between previously treated and untreated patients.
  • Regarding PN, no differences were found among untreated and pre-treated patients in the incidence (55% vs 52%, p=0.43), severity (NCI grade 3-4 9% vs 14%, p=0.27), and outcome (improved/resolved 90% vs 91%, p=0.58).
  • Concerning neuropathic pain, the incidence was lower (50% vs 81%, p=0.008) and solved earlier (35 days vs 91 days, p=0.02) in untreated compared with pre-treated patients.
  • Untreated patients needed dose modification less frequently (36% vs 73%, p=0.012).
  • In conclusion, incidence, severity and outcome of bortezomib-related PN are similar in untreated and pre-treated MM patients except for neuropathic pain which has lower incidence and shorter duration in untreated patients with less frequent need for bortezomib discontinuation.
  • [MeSH-minor] Activities of Daily Living. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bortezomib. Chemotherapy, Adjuvant. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoadjuvant Therapy. Neuralgia / chemically induced. Neuralgia / etiology. Risk Factors

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19674790.001).
  • [ISSN] 1873-5835
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Boronic Acids; 0 / Pyrazines; 69G8BD63PP / Bortezomib
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11. Yadav SK, Winter I, Singh SK: Management of intra-vitreal cysticercosis. Nepal J Ophthalmol; 2009 Jul-Dec;1(2):143-5
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  • Oocular cysticercosis is emerging as a common problem which if untreated can lead to severe visual loss in 3-5 years.
  • [MeSH-minor] Adult. Animals. Diagnosis, Differential. Female. Humans. Male. Young Adult

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  • (PMID = 21141010.001).
  • [ISSN] 2072-6805
  • [Journal-full-title] Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPH
  • [ISO-abbreviation] Nepal J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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12. Gillespie MJ, Davis CJ, Lambert ND, Costello FM, Smith SC, Cohen MG, Menon V: Measuring and treating serum lipids in patients in a chest pain observation unit. Am J Cardiol; 2007 Jun 15;99(12):1718-20
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  • Ten-year Framingham risk scores were retrospectively calculated for all patients according to the National Cholesterol Education Program and Adult Treatment Panel III 2001 recommendations.
  • Only 6% of patients with an indication for treatment (n=3) were prescribed a lipid-lowering medication on discharge, leaving 94% (n=47) untreated for their hypercholesterolemia.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cross-Sectional Studies. Female. Hospital Units. Humans. Male. Middle Aged. Prevalence. Retrospective Studies. Risk Factors

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  • (PMID = 17560881.001).
  • [ISSN] 0002-9149
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticholesteremic Agents; 0 / Cholesterol, LDL
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13. Rijkelijkhuizen JK, Töns A, Terpstra OT, Bouwman E: Transplantation of long-term cultured porcine islets in the rat: prolonged graft survival and recipient growth on reduced immunosuppression. Cell Transplant; 2010;19(4):387-98
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  • Islets were isolated from adult pigs, cultured for 1.5-3 weeks and transplanted to rats.
  • Untreated control recipients showed primary nonfunction (PNF).

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  • (PMID = 20021733.001).
  • [ISSN] 1555-3892
  • [Journal-full-title] Cell transplantation
  • [ISO-abbreviation] Cell Transplant
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine; 8N3DW7272P / Cyclophosphamide; AU0V1LM3JT / Gadolinium; P7082WY76D / gadolinium chloride
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14. Jain R, Tilak V: Evaluation of different serological techniques in laboratory diagnosis of brucellosis. J Indian Med Assoc; 2008 Aug;106(8):520, 522, 524
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  • Diagnosis of brucellosis is vital for early institution of proper therapy as untreated cases may progress to chronic stage.
  • [MeSH-minor] Adult. Agglutination Tests. Agglutinins / analysis. Case-Control Studies. Disease Progression. Electrophoresis. Female. Humans. India / epidemiology. Male. Middle Aged. Seroepidemiologic Studies

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  • (PMID = 18975512.001).
  • [ISSN] 0019-5847
  • [Journal-full-title] Journal of the Indian Medical Association
  • [ISO-abbreviation] J Indian Med Assoc
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Agglutinins
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15. Pett SL, McCarthy MC, Cooper DA, MacRae K, Tendolkar A, Norris R, Strizki JM, Williams KM, Emery S: A phase I study to explore the activity and safety of SCH532706, a small molecule chemokine receptor-5 antagonist in HIV type-1-infected patients. Antivir Ther; 2009;14(1):111-5
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  • The trial enrolled formerly treated (off therapy >3 months) or untreated HIV-1-infected patients.
  • [MeSH-minor] Abdominal Pain / chemically induced. Administration, Oral. Adult. CD4 Lymphocyte Count. Diarrhea / chemically induced. Drug Administration Schedule. Drug Therapy, Combination. HIV Protease Inhibitors / therapeutic use. Humans. Male. Middle Aged. Pericarditis / chemically induced. Ritonavir / therapeutic use. Viral Load


16. McKenzie EJ, Taylor PR, Stillion RJ, Lucas AD, Harris J, Gordon S, Martinez-Pomares L: Mannose receptor expression and function define a new population of murine dendritic cells. J Immunol; 2007 Apr 15;178(8):4975-83
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  • We have now observed that while MR(+) cells are consistently absent from T cell areas of spleen and mesenteric lymph nodes (LN), peripheral LN of untreated adult mice contain a minor population of MR(+)MHCII(+) in the paracortex.

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  • (PMID = 17404279.001).
  • [ISSN] 0022-1767
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoglobulin G; 0 / Lectins, C-Type; 0 / Lipopolysaccharides; 0 / Mannose-Binding Lectins; 0 / Receptors, Cell Surface; 0 / mannose receptor
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17. Antonelli A, Rotondi M, Fallahi P, Romagnani P, Ferrari SM, Barani L, Ferrannini E, Serio M: Increase of interferon-gamma-inducible CXC chemokine CXCL10 serum levels in patients with active Graves' disease, and modulation by methimazole therapy. Clin Endocrinol (Oxf); 2006 Feb;64(2):189-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • GD patients with untreated hyperthyroidism had higher sCXCL10 than hyperthyroid or euthyroid GD patients under methimazole (MMI) treatment (166+/-125, 124+/- 41 and 94+/- 35 pg/ml, respectively; P=0.006).
  • Comparable sCXCL10 levels were observed in newly diagnosed untreated hyperthyroid GD patients with respect to untreated patients with relapse of hyperthyroidism after a previous MMI course (176+/-125, 155+/- 97 pg/ml, respectively).
  • [MeSH-minor] Adult. Antibodies / blood. Chemokine CXCL10. Cross-Sectional Studies. Female. Goiter, Nodular / blood. Goiter, Nodular / drug therapy. Goiter, Nodular / immunology. Humans. Male. Middle Aged. Phenotype. Receptors, Thyrotropin / immunology. Thyroid Gland / physiopathology. Thyroiditis, Autoimmune / blood. Thyroiditis, Autoimmune / drug therapy. Thyroiditis, Autoimmune / immunology. Thyrotropin / blood. Treatment Outcome. Triiodothyronine / blood

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  • (PMID = 16430719.001).
  • [ISSN] 0300-0664
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antithyroid Agents; 0 / Chemokine CXCL10; 0 / Chemokines, CXC; 0 / Receptors, Thyrotropin; 06LU7C9H1V / Triiodothyronine; 554Z48XN5E / Methimazole; 82115-62-6 / Interferon-gamma; 9002-71-5 / Thyrotropin
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18. Takiguchi Y, Tada Y, Gemma A, Kudoh S, Hino M, Yoshimori K, Yoshimura A, Nagao K, Niitani H: Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer. Lung Cancer; 2010 Jun;68(3):409-14
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  • [Title] Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer.
  • The purpose of this phase I/II study is to evaluate a new combination chemotherapy consisting of docetaxel and S-1 as front-line therapy for patients with untreated advanced non-small cell lung cancer (NSCLC).
  • The present regimen showed a potent activity with mild toxicity in untreated NSCLC.
  • [MeSH-minor] Administration, Oral. Adult. Aged. Disease Progression. Drug Combinations. Drug Dosage Calculations. Drug Therapy, Combination. Female. Humans. Male. Middle Aged. Neoplasm Staging. Neutropenia / etiology. Survival Analysis

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  • [Copyright] Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19740565.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Taxoids; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 5VT6420TIG / Oxonic Acid
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19. Abdel Razek AA, Soliman NY, Elkhamary S, Alsharaway MK, Tawfik A: Role of diffusion-weighted MR imaging in cervical lymphadenopathy. Eur Radiol; 2006 Jul;16(7):1468-77
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  • In a prospective study, 31 untreated patients (22 males and nine females, aged 5-70 years) with 87 cervical lymph nodes underwent diffusion-weighted MRI before performance of neck dissection (n=14), surgical biopsy (n=9) or core biopsy (n=8).
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Neck. Reproducibility of Results. Sensitivity and Specificity

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  • (PMID = 16557366.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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20. Silva O, Lopes G, Morgenzstern D, Lobo C, Doliny P, Santos E, Abdullah S, Gautam U, Reis I, Welsh C, Slingerland J, Hurley J, Gluck S: A Phase II trial of split, low-dose docetaxel and low-dose capecitabine: a tolerable and efficacious regimen in the first-line treatment of patients with HER2/neu-negative metastatic breast cancer. Clin Breast Cancer; 2008 Apr;8(2):162-7
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  • PATIENTS AND METHODS: Patients with previously untreated HER2/neu-negative MBC were eligible.
  • [MeSH-minor] Adult. Aged. Capecitabine. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Disease-Free Survival. Female. Fluorouracil / administration & dosage. Fluorouracil / adverse effects. Fluorouracil / analogs & derivatives. Humans. Kaplan-Meier Estimate. Middle Aged. Receptor, ErbB-2 / metabolism. Taxoids / administration & dosage. Taxoids / adverse effects


21. Behrends T, Urbatzka R, Krackow S, Elepfandt A, Kloas W: Mate calling behavior of male South African clawed frogs (Xenopus laevis) is suppressed by the antiandrogenic endocrine disrupting compound flutamide. Gen Comp Endocrinol; 2010 Sep 1;168(2):269-74
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  • In this study adult male Xenopus laevis were injected with human chorionic gonadotropin (hCG) to initiate mate calling behavior.
  • After one day hCG-stimulated frogs were treated via aqueous exposure over three days without and with FLU at concentrations of 10(-8) and 10(-6) M in comparison to untreated frogs.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20138181.001).
  • [ISSN] 1095-6840
  • [Journal-full-title] General and comparative endocrinology
  • [ISO-abbreviation] Gen. Comp. Endocrinol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Endocrine Disruptors; 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol; 76W6J0943E / Flutamide; 9002-67-9 / Luteinizing Hormone; 9002-68-0 / Follicle Stimulating Hormone; EC 1.14.14.1 / Aromatase
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22. Kaminsky R, Mosimann D, Sager H, Stein P, Hosking B: Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. Int J Parasitol; 2009 Mar;39(4):443-6
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  • [Title] Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep.
  • Three dose determination studies were conducted in Australia and Europe to identify the therapeutic dose of monepantel, when formulated for the oral treatment of sheep, to control adult gastro-intestinal nematodes.
  • Following euthanasia and worm counting, their worm burdens were compared with those from untreated control groups.

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  • (PMID = 18950633.001).
  • [ISSN] 1879-0135
  • [Journal-full-title] International journal for parasitology
  • [ISO-abbreviation] Int. J. Parasitol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antinematodal Agents; 3739OQ10IJ / Aminoacetonitrile; 82MA79VJ33 / monepantel
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23. Thakur CP, Thakur S, Narayan S, Sinha A: Comparison of treatment regimens of kala-azar based on culture & sensitivity of amastigotes to sodium antimony gluconate. Indian J Med Res; 2008 Jun;127(6):582-8
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  • Primary outcome measured was as no relapse within 6 months of follow up after cure and other outcomes measured were period of stay of patients in hospital, expenditure involved in the treatment, and infectivity periods of two groups, two-third of treatment period and whole of untreated period were taken as infectivity period.
  • [MeSH-minor] Adolescent. Adult. Aged. Amphotericin B / therapeutic use. Animals. Child. Child, Preschool. Double-Blind Method. Drug Resistance. Female. Humans. India. Leishmania donovani / drug effects. Leishmania donovani / growth & development. Macrophages / parasitology. Male. Middle Aged

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  • (PMID = 18765878.001).
  • [ISSN] 0971-5916
  • [Journal-full-title] The Indian journal of medical research
  • [ISO-abbreviation] Indian J. Med. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Antiprotozoal Agents; 7XU7A7DROE / Amphotericin B; V083S0159D / Antimony Sodium Gluconate
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24. Wang M, Tsai BM, Kher A, Baker LB, Wairiuko GM, Meldrum DR: Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. Am J Physiol Heart Circ Physiol; 2005 Jan;288(1):H221-6
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  • [Title] Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion.
  • Myocardial ischemia is the leading cause of death in both men and women; however, very little information exists regarding the effect of testosterone on the response of myocardium to acute ischemic injury.
  • We hypothesized that testosterone may exert deleterious effects on myocardial inflammatory cytokine production, p38 MAPK activation, apoptotic signaling, and myocardial functional recovery after acute ischemia-reperfusion (I/R).
  • To study this, isolated, perfused rat hearts (Langendorff) from adult males, castrated males, and males treated with a testosterone receptor blocker (flutamide) were subjected to 25 min of ischemia followed by 40 min of reperfusion.
  • All indices of postischemic myocardial functional recovery were significantly higher in castrated males or flutamide-treated males compared with untreated males.
  • After I/R, castrated male and flutamide-treated male hearts had decreased TNF-alpha, IL-1beta, and IL-6; decreased activated p38 MAPK; decreased caspase-1, caspase-3, and caspase-11; and increased Bcl-2 expression compared with untreated males.
  • Further understanding may allow therapeutic manipulation of sex hormone signaling mechanisms in the treatment of acute I/R.
  • [MeSH-minor] Acute Disease. Animals. Caspases / metabolism. Heart / physiopathology. Male. Rats. Rats, Sprague-Dawley

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  • (PMID = 15374831.001).
  • [ISSN] 0363-6135
  • [Journal-full-title] American journal of physiology. Heart and circulatory physiology
  • [ISO-abbreviation] Am. J. Physiol. Heart Circ. Physiol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01-GM-070628
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 3XMK78S47O / Testosterone; EC 3.4.22.- / Caspases
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25. Trevisani L, Sartori S, Rossi MR, Ruina M, Matarese V, Gullini S, Abbasciano V: Evaluation of a new rapid immunoassay for the detection of Helicobacter pylori in faeces: a prospective pilot study. Aliment Pharmacol Ther; 2005 Feb 15;21(4):485-9
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  • CONCLUSIONS: ImmunoCard STAT seems a reliable method for detecting H. pylori in untreated patients.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Bacterial / analysis. Epidemiologic Methods. Female. Humans. Immunoassay / methods. Immunoenzyme Techniques. Male. Middle Aged. Reagent Kits, Diagnostic


26. Hall SA, Araujo AB, Esche GR, Williams RE, Clark RV, Travison TG, McKinlay JB: Treatment of symptomatic androgen deficiency: results from the Boston Area Community Health Survey. Arch Intern Med; 2008 May 26;168(10):1070-6
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  • The operational definition of untreated AD was serum total testosterone level less than 300 ng/dL (to convert to nanomoles per liter, multiply by 0.0347) and free testosterone level less than 5 ng/dL, and the presence of at least 1 specific symptom (low libido, erectile dysfunction, or osteoporosis) or 2 or more less-specific symptoms (sleep disturbance, depressed mood, lethargy, or diminished physical performance) and not using prescription testosterone.
  • A total of 5.5% (95% confidence interval, 3.5-8.5) men met the criteria for having untreated, symptomatic AD, and 0.8% (95% confidence interval, 0.4-1.4) met the criteria for having treated AD.
  • Men with untreated AD seemed to have adequate access to care.

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  • [CommentIn] Arch Intern Med. 2009 Jan 12;169(1):88; author reply 88-9 [19139331.001]
  • (PMID = 18504335.001).
  • [ISSN] 1538-3679
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / R01 AG020727; United States / NIDDK NIH HHS / DK / U01 DK056842; United States / NIDDK NIH HHS / DK / DK 56842
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 3XMK78S47O / Testosterone
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27. Smith MP, Giangrande P, Pollman H, Littlewood R, Kollmer C, Feingold J, Refacto St Louis Study Group: A postmarketing surveillance study of the safety and efficacy of ReFacto (St Louis-derived active substance) in patients with haemophilia A. Haemophilia; 2005 Sep;11(5):444-51
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  • Sixty patients, 58 previously treated and two previously untreated, were enrolled into this study.
  • One previously untreated patient (PUP) developed a transient low-titre inhibitor (0.4 BU).
  • [MeSH-minor] Adolescent. Adult. Aged. Blood Coagulation Factor Inhibitors / blood. Child. Child, Preschool. Drug Administration Schedule. Hemorrhage / etiology. Hemorrhage / prevention & control. Hemostasis, Surgical / methods. Humans. Infant. Male. Middle Aged. Product Surveillance, Postmarketing. Recombinant Proteins / adverse effects. Recombinant Proteins / therapeutic use

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  • (PMID = 16128886.001).
  • [ISSN] 1351-8216
  • [Journal-full-title] Haemophilia : the official journal of the World Federation of Hemophilia
  • [ISO-abbreviation] Haemophilia
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Coagulation Factor Inhibitors; 0 / Recombinant Proteins; 0 / recombinant factor VIII SQ; 9001-27-8 / Factor VIII
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28. Cao W, Jamieson BD, Hultin LE, Hultin PM, Detels R: Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression. AIDS Res Hum Retroviruses; 2009 Feb;25(2):183-91
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  • [Title] Regulatory T cell expansion and immune activation during untreated HIV type 1 infection are associated with disease progression.
  • To investigate the correlation between Tregs and immune activation during untreated chronic HIV-1 infection, we conducted a nested case-control study within the Multicenter AIDS Cohort Study (MACS).

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  • (PMID = 19239357.001).
  • [ISSN] 1931-8405
  • [Journal-full-title] AIDS research and human retroviruses
  • [ISO-abbreviation] AIDS Res. Hum. Retroviruses
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / U01 AI035040-15; United States / NIAID NIH HHS / AI / U01 AI 03540; United States / NIAID NIH HHS / AI / AI035040-17; United States / NIAID NIH HHS / AI / AI035040-15; United States / NIAID NIH HHS / AI / U01 AI035040-17; United States / NIAID NIH HHS / AI / U01 AI035040; United States / NIAID NIH HHS / AI / AI R01 058845
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors; 0 / Interleukin-2 Receptor alpha Subunit; EC 3.2.2.5 / Antigens, CD38
  • [Other-IDs] NLM/ NIHMS146028; NLM/ PMC2782619
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29. Uehara M, Shiraishi T, Tobita T, Nonaka M, Asahina I: Antitumor effects on primary tumor and metastatic lymph nodes by superselective intra-arterial concurrent chemoradiotherapy for oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Aug;110(2):172-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Superselective intra-arterial infusion of anticancer agents with concurrent delivery of external beam radiotherapy was applied to 13 previously untreated cases of oral cancer for the purpose of avoiding surgical resection of the primary tumor.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Catheterization / methods. Combined Modality Therapy. Humans. Infusions, Intra-Arterial / methods. Lymphatic Metastasis. Middle Aged. Neoplasm Staging. Remission Induction. Temporal Arteries. Treatment Outcome

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20382050.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Chou YW, Yang YH, Chen JH, Kuo CC, Chen SH: Quantification of meropenem in plasma and cerebrospinal fluid by micellar electrokinetic capillary chromatography and application in bacterial meningitis patients. J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Sep 1;856(1-2):294-301
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  • The separation of meropenem was carried out in an untreated fused-silica capillary (40.2 cm x 50 microm I.D., effective length 30 cm) and was performed at 25 degrees C using a background electrolyte consisting of Tris buffer (40 mM, pH 8.0) solution with sodium dodecyl sulfate (SDS) as the running buffer and on-column detection at 300 nm.
  • [MeSH-minor] Adult. Humans. Reproducibility of Results

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  • (PMID = 17625990.001).
  • [ISSN] 1570-0232
  • [Journal-full-title] Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • [ISO-abbreviation] J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Thienamycins; FV9J3JU8B1 / meropenem
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31. Duydu Y, Ustündağ A, Aydin A, Eken A, Dündar K, Uzun G: Increased sensitivity to mitomycin C-induced sister chromatid exchange in lymphocytes from patients undergoing hyperbaric oxygen therapy. Environ Mol Mutagen; 2006 Apr;47(3):185-91
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  • Unlike the case with untreated cells, MMC-induced SCE frequencies remained high in lymphocytes sampled at later stages of therapy and mean MMC-induced SCE frequencies were significantly higher (P < 0.05; n = 4) in lymphocytes sampled 1 day after the last session of HBOT than in lymphocytes sampled from these patients prior to beginning the therapy.
  • [MeSH-minor] Adult. Aged. Antioxidants / chemistry. Chromosome Aberrations. Chromosomes, Human. DNA Damage. Female. Humans. Hyperbaric Oxygenation. Male. Middle Aged. Mitomycin / pharmacology. Mitomycins / chemistry. Sensitivity and Specificity. T-Lymphocytes / metabolism. Time Factors

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16355392.001).
  • [ISSN] 0893-6692
  • [Journal-full-title] Environmental and molecular mutagenesis
  • [ISO-abbreviation] Environ. Mol. Mutagen.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Mitomycins; 50SG953SK6 / Mitomycin
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32. Hochster HS, Plimack ER, Mandeli J, Wadler S, Runowicz C, Goldberg G, Speyer J, Wallach R, Muggia F, New York Gynecologic Oncology Group (and phase II consortium) and the Eastern Cooperative Oncology: Prolonged topotecan infusion with cisplatin in the first-line treatment of ovarian cancer: an NYGOG and ECOG study. Gynecol Oncol; 2006 Feb;100(2):324-9
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  • PATIENTS AND METHODS: Women with previously untreated, measurable and non-measurable epithelial ovarian cancer, stages Ic-IV were eligible.
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Cisplatin / adverse effects. Female. Humans. Infusions, Intravenous. Middle Aged. Topotecan / administration & dosage. Topotecan / adverse effects

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  • (PMID = 16253316.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16087; United States / NCI NIH HHS / CA / CA21115-27; United States / NCI NIH HHS / CA / CA76642; United States / NCI NIH HHS / CM / N01-CM-07003-74S
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 7M7YKX2N15 / Topotecan; Q20Q21Q62J / Cisplatin
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33. Spatz ES, Ross JS, Desai MM, Canavan ME, Krumholz HM: Beyond insurance coverage: usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey. Am Heart J; 2010 Jul;160(1):115-21
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  • METHODS: Using the 2003-2006 National Health and Nutrition Examination Survey, we categorized USOC (a place to go when sick or need medical advice) and insurance status in adults >or=35 years old with an indication for medication treatment of hypertension (n = 3,142) and hypercholesterolemia (n = 1,134), determined using the Joint National Committee 7 and Adult Treatment Panel III recommendations, respectively.
  • RESULTS: Among subjects with an indication for treatment of hypertension and hypercholesterolemia, 32.4% and 42.0% were untreated, respectively.
  • When compared with adults with a USOC, adults without a USOC were more likely to be untreated for hypertension (adjusted prevalence ratio [aPR] 2.43, 95% CI 1.88-2.85) and hypercholesterolemia (aPR 1.79, 95% CI 1.31-2.13).
  • In stratified analyses among subjects with insurance, no USOC remained associated with being untreated (hypertension, aPR 2.58, 95% CI 1.88-3.08; hypercholesterolemia, aPR 1.65, 95% CI 0.97-2.18).
  • CONCLUSIONS: Absence of a USOC was associated with being untreated for hypertension and hypercholesterolemia, even among individuals with insurance, suggesting that efforts to improve chronic disease management should also facilitate access to a regular source of care.
  • [MeSH-minor] Adult. Aged. Cost-Benefit Analysis. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. United States

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
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  • (PMID = 20598981.001).
  • [ISSN] 1097-6744
  • [Journal-full-title] American heart journal
  • [ISO-abbreviation] Am. Heart J.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / K08 AG032886; United States / NIA NIH HHS / AG / K08 AG032886-02
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticholesteremic Agents; 0 / Antihypertensive Agents
  • [Other-IDs] NLM/ NIHMS262160; NLM/ PMC3025407
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34. Dujić M, Jevtović D: [Immune recovery vitritis]. Srp Arh Celok Lek; 2007 Sep-Oct;135(9-10):513-5
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  • This results in necrotic retinitis which, if untreated, leads to complete loss of vision.
  • [MeSH-minor] Acquired Immunodeficiency Syndrome / drug therapy. Adult. Aged. Antiretroviral Therapy, Highly Active. CD4 Lymphocyte Count. Eye Diseases / immunology. Eye Diseases / pathology. Humans. Middle Aged


35. Kumar A, Girdhar A, Girdhar BK: Prevalence of leprosy in Agra District (U.P.) India from 2001 to 20031. Int J Lepr Other Mycobact Dis; 2005 Jun;73(2):115-21
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  • Of the 592 cases, 523 (88.3%) were new untreated cases, giving a new case detection rate of 14.5/10,000.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Health Surveys. Humans. India / epidemiology. Infant. Male. Middle Aged. Mycobacterium leprae. Prevalence. Rural Health / statistics & numerical data. Urban Health / statistics & numerical data

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  • (PMID = 16830654.001).
  • [ISSN] 0148-916X
  • [Journal-full-title] International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
  • [ISO-abbreviation] Int. J. Lepr. Other Mycobact. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. Horn TD, Johnson SM, Helm RM, Roberson PK: Intralesional immunotherapy of warts with mumps, Candida, and Trichophyton skin test antigens: a single-blinded, randomized, and controlled trial. Arch Dermatol; 2005 May;141(5):589-94
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  • Resolution of distant untreated warts was observed, and was significantly more likely in subjects receiving antigen (P<.001).
  • [MeSH-minor] Adult. Antiviral Agents / adverse effects. Antiviral Agents / therapeutic use. Cell Division / drug effects. Female. Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use. Histocompatibility Antigens / blood. Humans. Injections, Intralesional. Interferon-alpha / adverse effects. Interferon-alpha / therapeutic use. Male. Monocytes / pathology. Papillomaviridae / immunology. Recombinant Proteins. Treatment Outcome

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  • (PMID = 15897380.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01RR14288
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Fungal; 0 / Antigens, Viral; 0 / Antiviral Agents; 0 / Histocompatibility Antigens; 0 / Interferon-alpha; 0 / Recombinant Proteins; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor; 99210-65-8 / interferon alfa-2b
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37. Fernando I, Thompson C: Audit of syphilis treatment, follow-up and contact-tracing rates. Int J STD AIDS; 2007 Feb;18(2):128-9
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  • In all, 101 patients were identified as untreated carriers or contacts requiring treatment, partner notification and follow-up.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. HIV Infections / diagnosis. HIV Infections / epidemiology. Humans. Male. Middle Aged. Scotland / epidemiology. Sexually Transmitted Diseases / diagnosis. Sexually Transmitted Diseases / epidemiology

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  • (PMID = 17331289.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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38. Roysommuti S, Suwanich A, Jirakulsomchok D, Wyss JM: Perinatal taurine depletion increases susceptibility to adult sugar-induced hypertension in rats. Adv Exp Med Biol; 2009;643:123-33
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  • [Title] Perinatal taurine depletion increases susceptibility to adult sugar-induced hypertension in rats.
  • Sprague-Dawley dams were either taurine depleted (beta-alanine 3% in water) or left untreated from conception to weaning.

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  • (PMID = 19239143.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] ENG
  • [Grant] United States / NINDS NIH HHS / NS / P30 NS047466; United States / NINDS NIH HHS / NS / NS057098-03; United States / NINDS NIH HHS / NS / P30 NS057098; United States / NCCIH NIH HHS / AT / AT000477-090005; United States / NCCIH NIH HHS / AT / AT 00477; United States / NINDS NIH HHS / NS / NS047466-02; United States / NINDS NIH HHS / NS / P30 NS057098-03; United States / NINDS NIH HHS / NS / NS047466-01A29001; United States / NCCIH NIH HHS / AT / P50 AT000477-090005; United States / NCCIH NIH HHS / AT / P50 AT000477; United States / NINDS NIH HHS / NS / P30 NS047466-01A29001; United States / NINDS NIH HHS / NS / P30 NS047466-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Carbohydrates; 1EQV5MLY3D / Taurine; IY9XDZ35W2 / Glucose
  • [Other-IDs] NLM/ NIHMS103678; NLM/ PMC2706705
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39. Baqi L, Payer J, Killinger Z, Hruzikova P, Cierny D, Susienkova K, Langer P: Thyrotropin versus thyroid hormone in regulating bone density and turnover in premenopausal women. Endocr Regul; 2010 Apr;44(2):57-63
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  • METHODS: Serum levels of free thyroxine (FT4), thyrotropin (TSH), calcium (Ca), alkaline phosphatase (ALP), osteocalcin OC) and cross linked N-telopeptide of type 1 collagen (NTx) as well as urinary calcium (U-Ca/24h), bone mineral density of lumbar spine L 1-4 (BMD-L) and femoral hip (BMD-F) were estimated in a cohort of 151 premenopausal women (median 36 years) consisting of four groups: Group 1, 40 healthy untreated women, while three other groups consisted of patients previously treated for about 5 years; Group 2, 41 patients with genuine hypothyroidism treated by L-thyroxine (50-100 microg daily); Group 3, 40 patients with genuine hyperthyroidism treated by Carbimazol (10-15 mg daily); Group 4, 30 patients treated by suppressive doses of L-thyroxine (100-150 microg daily) after thyroidectomy for thyroid cancer (n=10) or because of progressively growing benign goitre (n=20).
  • [MeSH-minor] Absorptiometry, Photon. Adult. Alkaline Phosphatase / blood. Antithyroid Agents / therapeutic use. Biomarkers / blood. Biomarkers / urine. Calcium / blood. Calcium / urine. Carbimazole / therapeutic use. Collagen Type I / blood. Cross-Sectional Studies. Female. Femur / metabolism. Femur / radiography. Goiter / blood. Goiter / physiopathology. Humans. Hyperthyroidism / blood. Hyperthyroidism / physiopathology. Hypothyroidism / blood. Hypothyroidism / physiopathology. Lumbar Vertebrae / metabolism. Lumbar Vertebrae / radiography. Middle Aged. Osteocalcin / blood. Peptides / blood. Thyroid Neoplasms / blood. Thyroid Neoplasms / physiopathology. Thyroidectomy. Young Adult

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  • (PMID = 20429634.001).
  • [ISSN] 1210-0668
  • [Journal-full-title] Endocrine regulations
  • [ISO-abbreviation] Endocr Regul
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Slovakia
  • [Chemical-registry-number] 0 / Antithyroid Agents; 0 / Biomarkers; 0 / Collagen Type I; 0 / Peptides; 0 / collagen type I trimeric cross-linked peptide; 104982-03-8 / Osteocalcin; 8KQ660G60G / Carbimazole; 9002-71-5 / Thyrotropin; EC 3.1.3.1 / Alkaline Phosphatase; Q51BO43MG4 / Thyroxine; SY7Q814VUP / Calcium
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40. Clark MA, Thomas JM: Delay in referral to a specialist soft-tissue sarcoma unit. Eur J Surg Oncol; 2005 May;31(4):443-8
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  • RESULTS: There were 159 patients with previously untreated soft-tissue sarcomas.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Medical Audit. Middle Aged. Prospective Studies. Risk Factors. Time Factors

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  • (PMID = 15837054.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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41. Lordick F, Lorenzen S, Stollfuss J, Vehling-Kaiser U, Kullmann F, Hentrich M, Zumschlinge R, Dietzfelbinger H, Thoedtmann J, Hennig M, Seroneit T, Bredenkamp R, Duyster J, Peschel C: Phase II study of weekly oxaliplatin plus infusional fluorouracil and folinic acid (FUFOX regimen) as first-line treatment in metastatic gastric cancer. Br J Cancer; 2005 Jul 25;93(2):190-4
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  • Patients with previously untreated metastatic gastric cancer received oxaliplatin (50 mg m(-2)) plus FA (500 mg m(-2), 2-h infusion) followed by 5-FU (2000 mg m(-2), 24-h infusion) given on days 1, 8, 15 and 22 of a 5-week cycle.
  • [MeSH-minor] Adult. Aged. Drug Administration Schedule. Female. Fluorouracil / administration & dosage. Humans. Infusions, Intravenous. Leucovorin / administration & dosage. Male. Middle Aged. Neoplasm Metastasis. Organoplatinum Compounds / administration & dosage. Treatment Outcome

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  • (PMID = 16012522.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Organoplatinum Compounds; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; FUFOX regimen
  • [Other-IDs] NLM/ PMC2361546
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42. Quoix E, Breton JL, Gervais R, Wilson J, Schramel F, Cardenal F, Ross G, Preston A, Lymboura M, Mattson K: A randomised phase II study of the efficacy and safety of intravenous topotecan in combination with either cisplatin or etoposide in patients with untreated extensive disease small-cell lung cancer. Lung Cancer; 2005 Aug;49(2):253-61
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  • [Title] A randomised phase II study of the efficacy and safety of intravenous topotecan in combination with either cisplatin or etoposide in patients with untreated extensive disease small-cell lung cancer.
  • This phase II study investigated the efficacy and safety of topotecan in combination with either cisplatin or etoposide in untreated extensive disease SCLC (ED SCLC).
  • PATIENTS AND METHODS: Patients with untreated ED SCLC were randomised to treatment with T/C (topotecan 1.25mg/(m(2)day) IV days 1-5, cisplatin 50mg/m(2) IV day 5; 41 patients) or T/E (topotecan 0.75 mg/(m(2)day) IV days 1-- 5, etoposide 60 mg/(m(2)day) IV days 1-5; 41 patients) every 21 days.
  • [MeSH-minor] Adult. Aged. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Infusions, Intravenous. Male. Maximum Tolerated Dose. Middle Aged. Survival Rate. Topotecan / administration & dosage. Treatment Outcome

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  • (PMID = 16022920.001).
  • [ISSN] 0169-5002
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase II; Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Ireland
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; 7M7YKX2N15 / Topotecan; Q20Q21Q62J / Cisplatin
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43. Richardson JD, Franklin GA, Heffley S, Seligson D: Operative fixation of chest wall fractures: an underused procedure? Am Surg; 2007 Jun;73(6):591-6; discussion 596-7
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  • However, a small subset of patients have fractures that produce overlying bone fragments that may produce severe pain, respiratory compromise, and, if untreated mechanically, result in nonunion.
  • [MeSH-minor] Adult. Biocompatible Materials. Bone Plates. Bone Screws. Chest Pain / radiography. Fracture Healing. Fractures, Ununited / surgery. Hospitalization. Humans. Imaging, Three-Dimensional. Middle Aged. Respiratory Insufficiency / radiography. Retrospective Studies. Time Factors. Titanium. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17658097.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; D1JT611TNE / Titanium
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44. Krych AJ, Foote RL, Brown PD, Garces YI, Link MJ: Long-term results of irradiation for paraganglioma. Int J Radiat Oncol Biol Phys; 2006 Jul 15;65(4):1063-6
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  • This risk must be weighed against the significant immediate and permanent risk of cranial nerve deficits if the tumor is untreated or is surgically resected.
  • [MeSH-minor] Adolescent. Adult. Aged. Carotid Body Tumor / radiotherapy. Carotid Body Tumor / surgery. Child. Female. Glomus Jugulare Tumor / radiotherapy. Glomus Jugulare Tumor / surgery. Glomus Tympanicum Tumor / radiotherapy. Glomus Tympanicum Tumor / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / radiotherapy. Neoplasms, Radiation-Induced / etiology. Radiotherapy / adverse effects. Retroperitoneal Neoplasms / radiotherapy

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  • (PMID = 16682153.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Jóźwiak M, Walczak M, Idzior M: [Appearance of spastic hip pain in cerebral palsy children]. Chir Narzadow Ruchu Ortop Pol; 2005;70(2):101-4
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  • Group 1-41 patients (77 spastic hips) without neurogenic instability of hip (mean value of migration percentage (MP) - 25%), group II - 14 patients (19 hips) with untreated dislocation of hip (MP - 100%), group III- 25 patients (30 hips) with dislocation and subluxation of hips treated by open reduction combined with Dega's pelvic osteotomy and intertrochanteric varus osteotomy of femur.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Osteotomy / methods. Retrospective Studies. Treatment Outcome


46. Jannasch O, Dombrowski F, Lippert H, Meyer F: Rare coincidence of familial adenomatous polyposis and a retroperitoneal fibromyxoid sarcoma: report of a case. Dis Colon Rectum; 2008 Apr;51(4):477-81
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  • All untreated patients will develop colorectal adenocarcinoma.
  • [MeSH-minor] Adult. Anastomosis, Surgical / methods. Colonic Pouches. Colonoscopy. Diagnosis, Differential. Follow-Up Studies. Humans. Laparotomy. Male. Proctocolectomy, Restorative / methods. Rectum / surgery. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18180996.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Poland TM, Haack RA, Petrice TR, Miller DL, Bauer LS: Laboratory evaluation of the toxicity of systemic insecticides for Control of Anoplophora glabripennis and Plectrodera scalator (Coleoptera: Cerambycidae). J Econ Entomol; 2006 Feb;99(1):85-93
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  • In a separate experiment, A. glabripennis adults were fed maple twigs treated with high and low concentrations of imidacloprid. A. glabripennis adult mortality reached 100% after 13 d on twigs treated with 150 ppm imidacloprid and after 20 d on twigs treated with 15 ppm imidacloprid.
  • There was no visible feeding by A. glabripennis adults on twigs treated at the higher imidacloprid rate, and feeding was significantly reduced for adults placed on twigs treated at the low imidacloprid rate compared with adults on untreated twigs.

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  • (PMID = 16573327.001).
  • [ISSN] 0022-0493
  • [Journal-full-title] Journal of economic entomology
  • [ISO-abbreviation] J. Econ. Entomol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Imidazoles; 0 / Insecticides; 0 / Limonins; 0 / Nitro Compounds; 3BN7M937V8 / imidacloprid; O4U1SAF85H / azadirachtin
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48. Budec M, Koko V, Todorović V, Marković D, Postić M, Drndarević N, Spasić A, Mitrović O: Possible mechanism of acute effect of ethanol on intestinal IgA expression in rat. Int Immunopharmacol; 2007 Jun;7(6):858-63
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  • [Title] Possible mechanism of acute effect of ethanol on intestinal IgA expression in rat.
  • The purpose of this study was to investigate the possible mechanism of acute effect of ethanol on IgA expression in rat intestine.
  • To this end, adult female Wistar rats showing diestrus day 1 were treated with (a) ethanol (2 or 4 g/kg, i.p.);.
  • Saline-injected and untreated rats were used as controls.
  • Morphometric analysis showed that acute ethanol treatment increased the number of IgA-immunoreactive cells in a dose-dependent manner.
  • Taken together, these data suggest that acute effect of ethanol on intestinal IgA might be mediated by endogenous nitric oxide.

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  • (PMID = 17466919.001).
  • [ISSN] 1567-5769
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Immunoglobulin A; 3K9958V90M / Ethanol; EC 1.14.13.39 / Nitric Oxide Synthase; V55S2QJN2X / NG-Nitroarginine Methyl Ester
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49. Loesch D, Asmar L, McIntyre K, Doane L, Monticelli M, Paul D, Vukelja S, Orlando M, Vaughn LG, Zhan F, Boehm KA, O'Shaughnessy JA: Phase II trial of gemcitabine/carboplatin (plus trastuzumab in HER2-positive disease) in patients with metastatic breast cancer. Clin Breast Cancer; 2008 Apr;8(2):178-86
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  • The gemcitabine/ cisplatin combination is highly active in MBC with response rates (RRs) of approximately 50% in anthracycline- and taxane-pretreated patients and up to 80% in untreated subjects.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Monoclonal, Humanized. Carboplatin / administration & dosage. Carboplatin / adverse effects. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Female. Humans. Kaplan-Meier Estimate. Middle Aged. Receptor, ErbB-2 / metabolism. Trastuzumab

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  • (PMID = 18621615.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; BG3F62OND5 / Carboplatin; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2; P188ANX8CK / Trastuzumab
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50. De Bellis A, Colao A, Savoia A, Coronella C, Pasquali D, Conte M, Pivonello R, Bellastella A, Sinisi AA, Bizzarro A, Lombardi G, Bellastella G: Effect of long-term cabergoline therapy on the immunological pattern and pituitary function of patients with idiopathic hyperprolactinaemia positive for antipituitary antibodies. Clin Endocrinol (Oxf); 2008 Aug;69(2):285-91
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  • Among the untreated patients, during the follow-up, those with APA positive (Group 1a) showed an increase of APA titres and PRL levels with partial pituitary impairment in some of them; instead those with APA negative (Group 2a) persisted negative with normal pituitary function despite persistent hyperprolactinaemia.
  • [MeSH-minor] Adult. Autoimmune Diseases / chemically induced. Autoimmune Diseases / epidemiology. Cohort Studies. Dopamine Agonists / adverse effects. Dopamine Agonists / pharmacology. Dopamine Agonists / therapeutic use. Female. Hormone Antagonists / adverse effects. Hormone Antagonists / pharmacology. Hormone Antagonists / therapeutic use. Humans. Longitudinal Studies. Male. Pituitary Diseases / chemically induced. Pituitary Diseases / epidemiology. Pituitary Function Tests. Seroepidemiologic Studies. Thyroid Hormones / blood. Thyrotropin / blood. Time Factors

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  • (PMID = 18221394.001).
  • [ISSN] 1365-2265
  • [Journal-full-title] Clinical endocrinology
  • [ISO-abbreviation] Clin. Endocrinol. (Oxf)
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Dopamine Agonists; 0 / Ergolines; 0 / Hormone Antagonists; 0 / Thyroid Hormones; 9002-71-5 / Thyrotropin; LL60K9J05T / cabergoline
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51. Iyer SN, Mangala R, Thara R, Malla AK: Preliminary findings from a study of first-episode psychosis in Montreal, Canada and Chennai, India: comparison of outcomes. Schizophr Res; 2010 Aug;121(1-3):227-33
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  • BACKGROUND: This article reports preliminary findings from a multi-year investigation of onset and course of previously untreated first-episode psychosis in two similarly structured treatment programs in Canada and India.
  • METHOD: Patients with first-episode non-affective psychosis receiving similar treatment in Chennai, India (N=61) and in Montreal, Canada (N=88) were evaluated for demographic variables, duration of untreated psychosis, and baseline diagnosis, and for positive, negative, and general psychopathology symptoms and overall functioning at baseline and one year.
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Canada / epidemiology. Female. Humans. India / epidemiology. Male. Psychiatric Status Rating Scales. Retrospective Studies. Statistics as Topic. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20619607.001).
  • [ISSN] 1573-2509
  • [Journal-full-title] Schizophrenia research
  • [ISO-abbreviation] Schizophr. Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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52. El-Shennawy AM, Mohamed AH, Abass M: Studies on parasitologic and haematologic activities of an enaminone derivative of 4-hydroxyquinolin-2(1H)-one against murine schistosomiasis mansoni. MedGenMed; 2007;9(1):15
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  • Ultrastructural examination revealed cellular activation in buffy coat and the liver in both the BDHQ- and PZQ-treated groups in comparison to the untreated one, whereas in the bone marrow and spleen, evidence of cellular activation was remarkable in the BDHQ-treated groups.
  • In conclusion, BDHQ exhibits high levels of activity against adult and juvenile stages of these parasites, which may be due to its mixed cellular and humoral immunologic mechanisms, as demonstrated by the significant increase of serum levels of IgE and IFN-gamma shown on electron microscopy.

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  • (PMID = 17435624.001).
  • [ISSN] 1531-0132
  • [Journal-full-title] MedGenMed : Medscape general medicine
  • [ISO-abbreviation] MedGenMed
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydroxyquinolines; 611-36-9 / 4-hydroxyquinoline; 6490C9U457 / Praziquantel
  • [Other-IDs] NLM/ PMC1925031
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53. Newman CB, Pakbaz RS, Nguyen AD, Kerber CW: Endovascular treatment of extensive cerebral sinus thrombosis. J Neurosurg; 2009 Mar;110(3):442-5
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  • Although thrombosis accounts for only 1% of all strokes, if it is left untreated patients suffer from continuing headaches, vague neurological complaints, and may even progress to coma and death.
  • New endovascular techniques and technology allow the possibility of more aggressive thrombolysis and thrombectomy in the setting of acute thrombosis.
  • [MeSH-minor] Adult. Cerebral Angiography. Female. Fibrinolytic Agents / therapeutic use. Humans. Recombinant Proteins / therapeutic use. Tissue Plasminogen Activator / therapeutic use. Tomography, X-Ray Computed

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  • (PMID = 18834264.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrinolytic Agents; 0 / Recombinant Proteins; 133652-38-7 / reteplase; EC 3.4.21.68 / Tissue Plasminogen Activator
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54. Dvorák M: [Gluten enteropathy--occurrence, diagnosis, therapy]. Cas Lek Cesk; 2005;144 Suppl 1:48-51
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  • It frequently presents with atypical symptoms, as many as 80% of adult patients have no gastrointestinal troubles at all.
  • Permanent gluten free diet is the cornerstone of the therapy; untreated gluten enteropathy is a serious illness, considered to be a significant precancerosis.

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  • (PMID = 15981987.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 27
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55. Aschoff P, Häntschel M, Oksüz M, Werner MK, Lichy M, Vogel W, Pfannenberg C: Integrated FDG-PET/CT for detection, therapy monitoring and follow-up of granulocytic sarcoma. Initial results. Nuklearmedizin; 2009;48(5):185-91
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  • AIM: Granulocytic sarcomas (GS) are rare extramedullary manifestations of myeloid or lymphoblastic leukaemia.
  • RESULTS: 52 untreated or recurrent GS lesions were detected by FDG-PET/CT and all showed an increased FDG uptake with a mean SUVmax and SUVavg of 5.1 and 3.4, respectively.
  • [MeSH-minor] Adult. Female. Fluorodeoxyglucose F18. Follow-Up Studies. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / radiography. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / radionuclide imaging. Leukemia, Myeloid, Acute / drug therapy. Leukemia, Myeloid, Acute / radiography. Leukemia, Myeloid, Acute / radionuclide imaging. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Retrospective Studies. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19710955.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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56. Kayani N, Bhurgri Y: Ductal carcinoma in situ (DCIS) in Karachi. J Pak Med Assoc; 2005 May;55(5):199-202
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  • If untreated, only 40% of these innocuous forms of DCIS become invasive over a time span of approximately 25-30 years.
  • [MeSH-minor] Adult. Female. Humans. Mammography. Middle Aged. Pakistan / epidemiology

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  • (PMID = 15960285.001).
  • [ISSN] 0030-9982
  • [Journal-full-title] JPMA. The Journal of the Pakistan Medical Association
  • [ISO-abbreviation] J Pak Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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57. Roh MR, Chung HJ, Chung KY: Effects of various parameters of the 1064 nm Nd:YAG laser for the treatment of enlarged facial pores. J Dermatolog Treat; 2009;20(4):223-8
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  • The other half of the face was left untreated as a control.
  • [MeSH-minor] Adult. Female. Humans. Middle Aged. Skin Aging. Young Adult

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  • (PMID = 19125363.001).
  • [ISSN] 1471-1753
  • [Journal-full-title] The Journal of dermatological treatment
  • [ISO-abbreviation] J Dermatolog Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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58. Fidias P, Pennell NA, Boral AL, Shapiro GI, Skarin AT, Eder JP Jr, Kwoh TJ, Geary RS, Johnson BE, Lynch TJ, Supko JG: Phase I study of the c-raf-1 antisense oligonucleotide ISIS 5132 in combination with carboplatin and paclitaxel in patients with previously untreated, advanced non-small cell lung cancer. J Thorac Oncol; 2009 Sep;4(9):1156-62
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  • [Title] Phase I study of the c-raf-1 antisense oligonucleotide ISIS 5132 in combination with carboplatin and paclitaxel in patients with previously untreated, advanced non-small cell lung cancer.
  • PATIENTS AND METHODS: Previously untreated patients with stage IIIB/IV NSCLC received ISIS 5132 by continuous intravenous infusion at 2.0 mg/kg/d for 14 days.
  • [MeSH-minor] Adult. Aged. Carboplatin / administration & dosage. Carboplatin / adverse effects. Carboplatin / pharmacokinetics. Female. Humans. Male. Maximum Tolerated Dose. Middle Aged. Paclitaxel / administration & dosage. Paclitaxel / adverse effects. Paclitaxel / pharmacokinetics

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  • (PMID = 19704336.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ISIS 5132; 0 / Thionucleotides; BG3F62OND5 / Carboplatin; EC 2.7.11.1 / Proto-Oncogene Proteins c-raf; P88XT4IS4D / Paclitaxel
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59. Corey KE, Ross AS, Wurcel A, Schulze Zur Wiesch J, Kim AY, Lauer GM, Chung RT: Outcomes and treatment of acute hepatitis C virus infection in a United States population. Clin Gastroenterol Hepatol; 2006 Oct;4(10):1278-82
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  • [Title] Outcomes and treatment of acute hepatitis C virus infection in a United States population.
  • BACKGROUND & AIMS: Acute hepatitis C infection progresses to chronic infection in up to 80% of infected persons.
  • Reports from Europe indicate that early treatment of acute hepatitis C infection produces sustained virologic response rates as high as 80%-98%.
  • However, the outcome of acute hepatitis C infection in United States cohorts is not well-characterized.
  • METHODS: We describe the clinical course of 28 episodes of acute hepatitis C infection in 24 persons at our institution.
  • CONCLUSIONS: Our experience with treated and untreated acute HCV infection is comparable to that observed in Europe.
  • Randomized trials to investigate immediate versus delayed treatment of acute hepatitis C infection are warranted.
  • In view of these strongly positive outcomes, increased vigilance for acute hepatitis C becomes essential.
  • [MeSH-minor] Acute Disease. Adolescent. Adult. DNA, Viral / analysis. Female. Follow-Up Studies. Genotype. Hepacivirus / genetics. Humans. Incidence. Male. Middle Aged. Retrospective Studies. Treatment Outcome. United States / epidemiology. Viral Load

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  • (PMID = 16931171.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI069939; United States / NIAID NIH HHS / AI / U19 AI066345
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral
  • [Other-IDs] NLM/ NIHMS13611; NLM/ PMC1828916
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60. Juliusson G, Antunovic P, Derolf A, Lehmann S, Möllgård L, Stockelberg D, Tidefelt U, Wahlin A, Höglund M: Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry. Blood; 2009 Apr 30;113(18):4179-87
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  • [Title] Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry.
  • Acute myeloid leukemia (AML) is most common in the elderly, and most elderly are thought to be unfit for intensive treatment because of the risk of fatal toxicity.
  • The Swedish Acute Leukemia Registry covers 98% of all patients with AML (nonacute promyelocytic leukemia) diagnosed in 1997 to 2005 (n = 2767), with a median follow-up of 5 years, and reports eligibility for intensive therapy, performance status (PS), complete remission rates, and survival.
  • This analysis provides unique real world data from a large, complete, and unselected AML population, both treated and untreated, and gives background to treatment decisions for the elderly.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Myeloid, Acute / drug therapy. Leukemia, Myeloid, Acute / mortality
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Aged. Aged, 80 and over. Cohort Studies. Decision Making. Female. Humans. Male. Middle Aged. Prognosis. Registries. Survival Rate. Sweden. Treatment Outcome. Young Adult


61. Gatcliffe TA, Tewari KS, Shah A, Brewster WR, Burger RA, Kuo JV, Monk BJ: A feasibility study of topotecan with standard-dose cisplatin and concurrent primary radiation therapy in locally advanced cervical cancer. Gynecol Oncol; 2009 Jan;112(1):85-9
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  • METHODS: Patients with primary, previously untreated, histologically confirmed invasive squamous cell, adenocarcinoma, or adenosquamous carcinoma of the uterine cervix, stages IB2-IVA were treated with external beam pelvic radiotherapy (45 Gy), intracavitary low dose rate brachytherapy (40 Gy) and a parametrial boost (5.4-9 Gy) with overall treatment time not to exceed 8 weeks.
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Adult. Aged. Brachytherapy. Carcinoma, Adenosquamous / drug therapy. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / radiotherapy. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / radiotherapy. Cisplatin / administration & dosage. Cisplatin / adverse effects. Combined Modality Therapy. Disease-Free Survival. Feasibility Studies. Female. Humans. Middle Aged. Neoplasm Staging. Survival Rate. Topotecan / administration & dosage. Topotecan / adverse effects


62. Karie S, Launay-Vacher V, Deray G, Isnard-Bagnis C: [Statins in patients with kidney failure: efficacy, tolerance, and prescription guidelines in patients with chronic kidney disease and renal transplant]. Presse Med; 2006 Feb;35(2 Pt 1):219-29
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  • BACKGROUND: Chronic kidney disease (CKD) is extremely common in adults, although often undiagnosed and thus untreated.
  • [MeSH-minor] Adult. Aged. Atorvastatin Calcium. Cardiovascular Diseases / prevention & control. Cholesterol / blood. Cholesterol, LDL / blood. Fatty Acids, Monounsaturated / administration & dosage. Fatty Acids, Monounsaturated / therapeutic use. Fluorobenzenes / administration & dosage. Fluorobenzenes / therapeutic use. Graft Rejection / prevention & control. Heptanoic Acids / administration & dosage. Heptanoic Acids / therapeutic use. Humans. Hypolipidemic Agents / administration & dosage. Hypolipidemic Agents / therapeutic use. Indoles / administration & dosage. Indoles / therapeutic use. Middle Aged. Pravastatin / administration & dosage. Pravastatin / therapeutic use. Primary Prevention. Prospective Studies. Proteinuria / drug therapy. Proteinuria / etiology. Pyrimidines / administration & dosage. Pyrimidines / therapeutic use. Pyrroles / administration & dosage. Pyrroles / therapeutic use. Randomized Controlled Trials as Topic. Renal Dialysis. Risk Factors. Rosuvastatin Calcium. Simvastatin / administration & dosage. Simvastatin / therapeutic use. Sulfonamides / administration & dosage. Sulfonamides / therapeutic use. Time Factors

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  • (PMID = 16493350.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anticholesteremic Agents; 0 / Cholesterol, LDL; 0 / Fatty Acids, Monounsaturated; 0 / Fluorobenzenes; 0 / Heptanoic Acids; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / Hypolipidemic Agents; 0 / Indoles; 0 / Pyrimidines; 0 / Pyrroles; 0 / Sulfonamides; 48A5M73Z4Q / Atorvastatin Calcium; 4L066368AS / fluvastatin; 83MVU38M7Q / Rosuvastatin Calcium; 97C5T2UQ7J / Cholesterol; AGG2FN16EV / Simvastatin; KXO2KT9N0G / Pravastatin
  • [Number-of-references] 72
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63. Treliński J, Wierzbowska A, Krawczyńska A, Sakowicz A, Pietrucha T, Smolewski P, Robak T, Chojnowski K: Plasma levels of angiogenic factors and circulating endothelial cells in essential thrombocythemia: correlation with cytoreductive therapy and JAK2-V617F mutational status. Leuk Lymphoma; 2010 Sep;51(9):1727-33
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  • Using cytofluorimetric analysis, the levels of angiogenic factors, as well as the number of circulating endothelial cells (CECs), were determined in 65 patients with ET, including 33 previously untreated and 32 receiving cytoreductive therapy.
  • We found significantly higher levels of vascular endothelial growth factor (VEGF) and markedly decreased levels of placental growth factor in untreated patients with ET with respect to control subjects.
  • Furthermore, the levels of VEGF in patients on hydroxyurea (HU) therapy were markedly lower than in untreated patients.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Apoptosis. Case-Control Studies. Female. Flow Cytometry. Humans. Male. Middle Aged. Neovascularization, Pathologic / drug therapy. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length. Pregnancy Proteins / blood. Vascular Endothelial Growth Factor A / blood

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  • (PMID = 20615083.001).
  • [ISSN] 1029-2403
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenic Proteins; 0 / Antineoplastic Agents; 0 / Pregnancy Proteins; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 144589-93-5 / placenta growth factor; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2; X6Q56QN5QC / Hydroxyurea
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64. Ruan GR, Chen SS, Ma X, Chang Y, Wan H, Fu JY, Qin YZ, Li JL, Liu YR: [Abnormal expression of PDCD5 in the bone marrow cells of adult acute myeloid leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2007 Jun;15(3):462-5
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  • [Title] [Abnormal expression of PDCD5 in the bone marrow cells of adult acute myeloid leukemia].
  • The objective of this study was to estimate a novel apoptosis-promoting molecule PDCD5 expression in the bone marrow cells from adult acute myeloid leukemia (AML) for investigation of its significance in the pathogenesis of AML.
  • The results showed that the mean PDCD5 fluorescence intensity in bone marrow nucleated cells (MNC) from the bone marrow of 36 untreated AML patients was significantly lower than that from the bone marrow of 30 normal controls (3059 +/- 1392) vs (7432 +/- 1261) (P < 0.01).
  • The mean PDCD5 fluorescence intensity was lower in the marrow granulocytes, monocytes, blast cells, and lymphocytes from untreated AML patients than that from normal (3939 +/- 2121) vs (8367 +/- 1045); (3156 +/- 1635) vs (5917 +/- 2329); (2824 +/- 1592) vs (3998 +/- 2106); (1474 +/- 816) vs (3355 +/- 2042) respectively, (all P < 0.01).
  • It is concluded that PDCD5 expression in MNC in untreated AML patients is lower than that in the normal.
  • PDCD5 expression in the marrow granulocytes, monocytes, blast cells, and lymphocytes of untreated AML patients is significantly lower than that in the normal.

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  • (PMID = 17605845.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Neoplasm Proteins; 0 / PDCD5 protein, human
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65. Rosenberg H, Davis M, James D, Pollock N, Stowell K: Malignant hyperthermia. Orphanet J Rare Dis; 2007;2:21
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  • The syndrome is likely to be fatal if untreated.
  • [MeSH-minor] Adolescent. Adult. Aged. Animals. Child. Child, Preschool. Diagnosis, Differential. Female. Genetic Predisposition to Disease. Genetic Testing / methods. Humans. Infant. Infant, Newborn. Male. Masseter Muscle / drug effects. Middle Aged. Muscle Rigidity / chemically induced. Muscle Rigidity / complications. Muscular Diseases / diagnosis. Myopathy, Central Core / complications. Myopathy, Central Core / genetics. Neuromuscular Depolarizing Agents / adverse effects. Succinylcholine / adverse effects

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  • (PMID = 17456235.001).
  • [ISSN] 1750-1172
  • [Journal-full-title] Orphanet journal of rare diseases
  • [ISO-abbreviation] Orphanet J Rare Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neuromuscular Depolarizing Agents; J2R869A8YF / Succinylcholine
  • [Number-of-references] 110
  • [Other-IDs] NLM/ PMC1867813
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66. He FJ, Marciniak M, Markandu ND, Antonios TF, MacGregor GA: Effect of modest salt reduction on skin capillary rarefaction in white, black, and Asian individuals with mild hypertension. Hypertension; 2010 Aug;56(2):253-9
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  • We carried out a 12-week randomized double-blind crossover trial to determine the effect of a modest reduction in salt intake on capillary rarefaction in 71 whites, 69 blacks, and 29 Asians with untreated mildly raised blood pressure.
  • [MeSH-minor] Adult. African Continental Ancestry Group. Aged. Aldosterone / blood. Asian Continental Ancestry Group. Double-Blind Method. European Continental Ancestry Group. Fingers / blood supply. Hemoglobins / metabolism. Humans. Microscopy, Video / methods. Middle Aged. Placebos. Polarography / methods. Renin / blood. Systole / physiology

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  • (PMID = 20585106.001).
  • [ISSN] 1524-4563
  • [Journal-full-title] Hypertension (Dallas, Tex. : 1979)
  • [ISO-abbreviation] Hypertension
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins; 0 / Placebos; 4964P6T9RB / Aldosterone; EC 3.4.23.15 / Renin
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67. McCredie MR, Sharples KJ, Paul C, Baranyai J, Medley G, Jones RW, Skegg DC: Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol; 2008 May;9(5):425-34
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  • Women with untreated CIN3 are at high risk of cervical cancer, whereas the risk is very low in women treated conventionally throughout.
  • [MeSH-minor] Adult. Aged. Biopsy. Cohort Studies. Colposcopy. Disease Progression. Female. Humans. Hysterectomy. Incidence. Kaplan-Meier Estimate. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neoplasm, Residual. New Zealand / epidemiology. Proportional Hazards Models. Refusal to Treat. Retrospective Studies. Risk Assessment. Time Factors. Treatment Outcome. Vaginal Smears


68. Mi YC, Xue YP, Yu WJ, Liu SH, Zhao YZ, Meng QX, Bian SG, Wang JX: [Effectiveness analysis of HA based triple-drug regimen as induction chemotherapy in the treatment of acute myeloid leukemia and its relationship with karyotype]. Zhonghua Xue Ye Xue Za Zhi; 2005 Dec;26(12):705-9
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  • [Title] [Effectiveness analysis of HA based triple-drug regimen as induction chemotherapy in the treatment of acute myeloid leukemia and its relationship with karyotype].
  • OBJECTIVE: To analyze the complete remission (CR) rate, disease free survival (DFS) and overall survival (OS) of de novo acute myeloid leukemia (AML) patients treated with HA based three drugs induction chemotherapy and to explore the impact of cytogenetic abnormalities on the prognosis.
  • METHODS: Two hundred and forty-three untreated de novo AML patients were treated with HA based three drugs induction therapy.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Leukemia, Myeloid, Acute / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cytarabine / administration & dosage. Disease-Free Survival. Female. Follow-Up Studies. Harringtonines / administration & dosage. Humans. Karyotyping. Male. Middle Aged. Prognosis. Remission Induction. Retrospective Studies. Treatment Outcome

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  • (PMID = 16620570.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Harringtonines; 04079A1RDZ / Cytarabine
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69. Tilleul P, Tredan G, Austruy G, Maury E, Offenstadt G, Guidet B: Prophylactic low-molecular-weight heparin: prescription practice in an intensive care unit. J Crit Care; 2006 Jun;21(2):173-8
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  • RESULTS: One hundred thirty-six patients (71 treated with LMWH and 65 untreated) were included in the study (mean age, 60 +/- 18 years; SAPS (Simplified Acute Physiology Score) II, 39 +/- 23).
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anticoagulants / therapeutic use. Creatinine / metabolism. Double-Blind Method. Female. Humans. Male. Middle Aged. Monitoring, Physiologic. Platelet Count. Prospective Studies

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  • (PMID = 16769462.001).
  • [ISSN] 0883-9441
  • [Journal-full-title] Journal of critical care
  • [ISO-abbreviation] J Crit Care
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticoagulants; 0 / Heparin, Low-Molecular-Weight; AYI8EX34EU / Creatinine; S79O08V79F / Dalteparin
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70. Sattar T, Griffeth LK, Latifi HR, Glass J, Munker R, Lilien DL: PET imaging today: contribution to the initial staging and prognosis of patients with non-Hodgkin's lymphomas. J La State Med Soc; 2006 Jul-Aug;158(4):193-201
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  • In the present study, we investigated 77 untreated patients with different histologies of NHL both with conventional imaging techniques and FDG-PET.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Fluorodeoxyglucose F18. Humans. Male. Medical Audit. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 17022364.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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71. Barrett EA, Sundet K, Faerden A, Nesvåg R, Agartz I, Fosse R, Mork E, Steen NE, Andreassen OA, Melle I: Suicidality before and in the early phases of first episode psychosis. Schizophr Res; 2010 Jun;119(1-3):11-7
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  • 1) prior to study entry and 2) explicitly in the period of untreated psychosis.
  • RESULTS: Nearly 26% of the patients attempted suicide prior to study entry and 14% made suicide attempts during the period of untreated psychosis.
  • Of the patients who had been suicidal (i.e. experienced suicidal ideation or attempts), 70% were suicidal during the period of untreated psychosis.
  • Suicide attempts during untreated psychosis were also associated with more depressive episodes and younger age at illness onset, in addition to drug use the last six months and longer duration of untreated psychosis (DUP).
  • CONCLUSION: The prevalence of suicidality before and in the early phases of FEP is high, especially during untreated psychosis.
  • As prolonged DUP is associated with suicide attempts during the period of untreated psychosis, reducing the DUP could have the effect of reducing the prevalence of suicide attempts in patients with FEP.
  • [MeSH-minor] Adult. Alcoholism / diagnosis. Alcoholism / epidemiology. Comorbidity. Cross-Sectional Studies. Depressive Disorder, Major / diagnosis. Depressive Disorder, Major / epidemiology. Early Diagnosis. Female. Humans. Male. Psychiatric Status Rating Scales. Risk Factors. Sex Factors. Substance-Related Disorders / diagnosis. Substance-Related Disorders / epidemiology. Young Adult

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  • [Copyright] Copyright (c) 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20399077.001).
  • [ISSN] 1573-2509
  • [Journal-full-title] Schizophrenia research
  • [ISO-abbreviation] Schizophr. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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72. Unger KR, Lominska CE, Deeken JF, Davidson BJ, Newkirk KA, Gagnon GJ, Hwang J, Slack RS, Noone AM, Harter KW: Fractionated stereotactic radiosurgery for reirradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys; 2010 Aug 1;77(5):1411-9
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  • Thirty-eight patients were treated definitively and 27 patients with metastatic disease and/or untreated local disease were treated palliatively.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antineoplastic Agents / therapeutic use. Feasibility Studies. Female. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local / surgery. Neoplasms, Second Primary / surgery. Palliative Care / methods. Proportional Hazards Models. Radiotherapy Dosage. Retreatment / methods. Treatment Outcome. Young Adult

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [CommentIn] Int J Radiat Oncol Biol Phys. 2012 Mar 15;82(4):1323; author reply 1323-4 [22385722.001]
  • (PMID = 20056341.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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73. Liu CW, Ye W, Liu B, Zeng R, Wu W, Dake MD: Endovascular treatment of aortic pseudoaneurysm in Behçet disease. J Vasc Surg; 2009 Nov;50(5):1025-30
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  • The only untreated aneurysm, which coexisted with a treated lesion, remained stable under imaging observation.
  • [MeSH-minor] Adult. Aortic Rupture / etiology. Aortography / methods. Blood Vessel Prosthesis. Combined Modality Therapy. Feasibility Studies. Female. Humans. Male. Medication Adherence. Middle Aged. Prosthesis Design. Reoperation. Secondary Prevention. Stents. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 19660895.001).
  • [ISSN] 1097-6809
  • [Journal-full-title] Journal of vascular surgery
  • [ISO-abbreviation] J. Vasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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74. McManus BL, Fuller BW, Boetel MA, French BW, Ellsbury MM, Head GP: Abundance of Coleomegilla maculata (Coleoptera: Coccinellidae) in corn rootworm-resistant Cry3Bb1 maize. J Econ Entomol; 2005 Dec;98(6):1992-8
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  • This study evaluated impacts of Cry3Bb1 protein-expressing maize, tefluthrin-treated maize, and untreated controls on lady beetle abundance at preanthesis, anthesis, and postanthesis maize-developmental periods near Brookings in eastern South Dakota during 2001 and 2002.
  • It comprised 73.5 and 69.9% of all adult Coccinellidae caught in 2001 and 2002, respectively.
  • Numbers of C. maculata captured in Cry3Bb1 maize were not significantly different from those in untreated plots during preanthesis, and adults were more abundant in Cry3Bb1 maize than in tefluthrin-treated and untreated plots during anthesis and postanthesis.
  • Whole-plant sampling confirmed C. maculata predominance with the species representing 89.2 and 91.4% of all adult lady beetles observed in 2001 and 2002, respectively.

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  • (PMID = 16539124.001).
  • [ISSN] 0022-0493
  • [Journal-full-title] Journal of economic entomology
  • [ISO-abbreviation] J. Econ. Entomol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cry3Bbl endotoxin, Bacillus thuringiensis; 0 / Endotoxins
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75. Bae JH, Lee SJ, Lee A, Park YG, Bae SN, Park JS, Namkoong SE: Neoadjuvant cisplatin and etoposide followed by radical hysterectomy for stage 1B-2B cervical cancer. Gynecol Oncol; 2008 Dec;111(3):444-8
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  • METHODS: Previously untreated patients with histologically confirmed stage 1B-2B cervical cancer were treated with three courses of NACT (60 mg/m2 cisplatin on days 1 and 2 plus 100 mg/m2 etoposide on day 1) every 10 days.
  • [MeSH-minor] Adult. Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Cisplatin / adverse effects. Disease-Free Survival. Etoposide / administration & dosage. Etoposide / adverse effects. Female. Follow-Up Studies. Humans. Hysterectomy. Middle Aged. Neoadjuvant Therapy. Neoplasm Staging. Young Adult


76. Kowalewski M, Baszuk-Stefaniuk E, Urban M, Peczyńska J: Heart rate variability and left ventricular mass in slim children and young adults with hypertension. Kardiol Pol; 2005 Dec;63(6):605-10; discussion 611-2
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  • INTRODUCTION: Uncontrolled arterial hypertension brings direct and long-term sequelae in adult age, such as stroke, ischaemic heart disease with myocardial infarction, left ventricular hypertrophy or cardiac arrhythmia.
  • METHODS: 35 children aged 14.4+/-3.1 with idiopathic untreated arterial hypertension were enrolled.
  • [MeSH-minor] Adolescent. Adult. Child. Electrocardiography. Female. Humans. Male

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  • (PMID = 16380859.001).
  • [ISSN] 0022-9032
  • [Journal-full-title] Kardiologia polska
  • [ISO-abbreviation] Kardiol Pol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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77. Herold M, Haas A, Srock S, Neser S, Al-Ali KH, Neubauer A, Dölken G, Naumann R, Knauf W, Freund M, Rohrberg R, Höffken K, Franke A, Ittel T, Kettner E, Haak U, Mey U, Klinkenstein C, Assmann M, von Grünhagen U, East German Study Group Hematology and Oncology Study: Rituximab added to first-line mitoxantrone, chlorambucil, and prednisolone chemotherapy followed by interferon maintenance prolongs survival in patients with advanced follicular lymphoma: an East German Study Group Hematology and Oncology Study. J Clin Oncol; 2007 May 20;25(15):1986-92
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  • PATIENTS AND METHODS: Previously untreated patients with stage III or IV CD20+ indolent or mantle cell lymphoma were randomly assigned to either eight 28-day cycles of MCP plus rituximab (R-MCP; n = 181) or eight cycles of MCP alone (n = 177).
  • CONCLUSION: The R-MCP regimen significantly improves complete and overall response rates, EFS, PFS, and OS in patients with previously untreated advanced FL, without a clinically significant increase in toxicity.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal, Murine-Derived. Chlorambucil / administration & dosage. Female. Humans. Interferon-alpha / administration & dosage. Male. Middle Aged. Mitoxantrone / administration & dosage. Prednisolone / administration & dosage. Prognosis. Recombinant Proteins. Rituximab. Survival Rate. Treatment Outcome


78. Chanbang Y, Arthur FH, Wilde GE, Throne JE, Subramanyam B: Susceptibility of eggs and adult fecundity of the lesser grain borer, Rhyzopertha dominca, exposed to methoprene. J Insect Sci; 2008;8:1-5
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  • [Title] Susceptibility of eggs and adult fecundity of the lesser grain borer, Rhyzopertha dominca, exposed to methoprene.
  • In the first test, the hatch rate of eggs exposed on filter paper treated with methoprene at the label rate of 0.003 mg [AI]/cm(2) when used as a surface treatment in structures was 52.0 +/- 7.3% compared to 93.0 +/- 3.3% on untreated controls.
  • Egg hatch was directly proportional to concentration and ranged from 85.0 +/- 2.0% on untreated controls to 26.7 +/- 8.3% at the highest concentration tested.
  • On untreated rice kernels, 67.5 +/- 11.6% of the eggs hatched and were able to bore inside, and all of these larvae emerged as adults.
  • The number of eggs from adults on untreated rice was 52.1 +/- 4.3 eggs per female, and on treated rice the average egg production was 12.5 +/- 1.1 eggs per female.

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  • [Cites] Annu Rev Entomol. 1975;20:417-60 [1090243.001]
  • [Cites] J Econ Entomol. 2003 Apr;96(2):510-8 [14994822.001]
  • (PMID = 20233095.001).
  • [ISSN] 1536-2442
  • [Journal-full-title] Journal of insect science (Online)
  • [ISO-abbreviation] J. Insect Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 8B830OJ2UX / Methoprene
  • [Other-IDs] NLM/ PMC3127415
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79. Markkanen H, Pekkarinen T, Välimäki MJ, Alfthan H, Kauppinen-Mäkelin R, Sane T, Stenman UH: Effect of sex and assay method on serum concentrations of growth hormone in patients with acromegaly and in healthy controls. Clin Chem; 2006 Mar;52(3):468-73
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  • METHODS: To compare the results and subsequent patient classification obtained with 3 GH assays, we obtained basal serum samples from 78 apparently healthy adult controls (43 women and 35 men; median age, 32.5 years) and from 71 treated (44 women and 27 men; median age, 55.2 years) and 7 untreated acromegaly patients (4 women and 3 men; median age, 54.6 years), and OGTT was performed on all patients and on 72 of the 78 controls.
  • [MeSH-minor] Adult. Female. Humans. Immunoassay / methods. Male. Middle Aged. Reference Values. Serum. Sex Factors

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  • (PMID = 16439607.001).
  • [ISSN] 0009-9147
  • [Journal-full-title] Clinical chemistry
  • [ISO-abbreviation] Clin. Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 12629-01-5 / Human Growth Hormone
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80. Ertugrul DT, Yavuz B, Ata N, Yalcin AA, Kucukazman M, Algul B, Dal K, Akin KO, Deveci OS, Canbolat N, Ure OS, Tutal E: Decreasing brain natriuretic peptide levels after treatment for hyperthyroidism. Endocr J; 2009;56(9):1043-8
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  • The study population consisted of 48 consecutive newly diagnosed untreated overt hyper-thyroid patients who had not been treated any anti-thyroid medications before.
  • [MeSH-minor] Adult. Diagnostic Errors. Echocardiography, Doppler. Female. Heart Failure / diagnosis. Hemodynamics / drug effects. Humans. Male. Middle Aged. Thyrotropin / blood. Thyroxine / blood. Treatment Outcome. Triiodothyronine / blood

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  • (PMID = 19738361.001).
  • [ISSN] 1348-4540
  • [Journal-full-title] Endocrine journal
  • [ISO-abbreviation] Endocr. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 06LU7C9H1V / Triiodothyronine; 114471-18-0 / Natriuretic Peptide, Brain; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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81. Kasperska-Zajac A, Brzoza Z, Rogala B: Circulating level of the platelet-derived CXC chemokine platelet factor 4 in chronic urticaria patients with or without coexistent euthyroid Hashimoto's thyroiditis. Autoimmunity; 2006 Jun;39(4):265-8
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  • Plasma level of PF-4 was analysed using enzyme-linked immunosorbent assay in twelve women with strong positive response to autologous serum skin test (ASST) suffering from CU, twelve female patients with strong positive ASST suffering from both CU and untreated, HT as well as sixteen healthy women.
  • [MeSH-minor] Adult. Autoantibodies / blood. Enzyme-Linked Immunosorbent Assay. Female. Humans. Platelet Count. Skin Tests. Statistics, Nonparametric. Thyrotropin / blood. Thyroxine / blood

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  • (PMID = 16891214.001).
  • [ISSN] 0891-6934
  • [Journal-full-title] Autoimmunity
  • [ISO-abbreviation] Autoimmunity
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantibodies; 37270-94-3 / Platelet Factor 4; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
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82. Vaduganathan M, Stone NJ, Lee R, McGee EC Jr, Malaisrie SC, Silverberg RA, Kansal P, McCarthy PM: Perioperative statin therapy reduces mortality in normolipidemic patients undergoing cardiac surgery. J Thorac Cardiovasc Surg; 2010 Nov;140(5):1018-27
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  • (1) statin-untreated normolipidemic (NL-, n = 1052);.
  • (3) statin-untreated hyperlipidemic (HL-, n = 638); and (4) statin-treated hyperlipidemic (HL+, n = 1160) patients.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cause of Death. Chi-Square Distribution. Chicago. Coronary Artery Bypass / mortality. Drug Administration Schedule. Female. Hospital Mortality. Humans. Kaplan-Meier Estimate. Logistic Models. Male. Middle Aged. Odds Ratio. Proportional Hazards Models. Retrospective Studies. Risk Assessment. Risk Factors. Time Factors. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
  • [ErratumIn] J Thorac Cardiovasc Surg. 2011 Sep;142(3):726. Kansal, Preeti [added]
  • (PMID = 20851427.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors
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83. Kertzman S, Reznik I, Hornik-Lurie T, Weizman A, Kotler M, Amital D: Stroop performance in major depression: selective attention impairment or psychomotor slowness? J Affect Disord; 2010 Apr;122(1-2):167-73
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  • METHODS: The present study attempted to identify possible neuropsychological mechanisms involved in this impairment in untreated MDD outpatients (n=75) as compared to healthy subjects (n=83).
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Psychometrics / statistics & numerical data. Reference Values. Reproducibility of Results

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  • [Copyright] Copyright 2009 Elsevier B.V. All rights reserved.
  • (PMID = 19732958.001).
  • [ISSN] 1573-2517
  • [Journal-full-title] Journal of affective disorders
  • [ISO-abbreviation] J Affect Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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84. Chang HM, Wu UI, Lin TB, Lan CT, Chien WC, Huang WL, Shieh JY: Total sleep deprivation inhibits the neuronal nitric oxide synthase and cytochrome oxidase reactivities in the nodose ganglion of adult rats. J Anat; 2006 Aug;209(2):239-50
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  • [Title] Total sleep deprivation inhibits the neuronal nitric oxide synthase and cytochrome oxidase reactivities in the nodose ganglion of adult rats.
  • The results indicated that in normal untreated rats, numerous NADPH-d/NOS- and COX-reactive neurons were found in the nodose ganglion (NG).
  • Following TSD, however, both the labelling and staining intensity of NADPH-d/NOS as well as COX reactivity were drastically reduced in the NG compared with normal untreated ganglions.
  • MAP was significantly higher in TSD rats (136+/-4 mmHg) than in normal untreated rats (123+/-2 mmHg).

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  • (PMID = 16879602.001).
  • [ISSN] 0021-8782
  • [Journal-full-title] Journal of anatomy
  • [ISO-abbreviation] J. Anat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 1.14.13.39 / Nitric Oxide Synthase; EC 1.6.99.1 / NADPH Dehydrogenase; EC 1.9.3.1 / Electron Transport Complex IV
  • [Other-IDs] NLM/ PMC2100318
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85. Merinville E, Byrne AJ, Rawlings AV, Muggleton AJ, Laloeuf AC: Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin. J Cosmet Dermatol; 2010 Sep;9(3):174-84
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  • RESULTS: In the first study SS produced significant increases of the fibrillin and collagen-1 anti-aging biomarkers compared with the untreated skin control.
  • [MeSH-minor] Adult. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Biopsy. Double-Blind Method. Humans. Light / adverse effects. Middle Aged. Photography. Placebos. Procollagen / metabolism. Skin Physiological Phenomena. Software

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  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 20883290.001).
  • [ISSN] 1473-2165
  • [Journal-full-title] Journal of cosmetic dermatology
  • [ISO-abbreviation] J Cosmet Dermatol
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Placebos; 0 / Procollagen; 11103-57-4 / Vitamin A; WIQ1H85SYP / Sodium Salicylate
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86. Jonsson T, Arnlaugsson S, Saemundsson SR, Magnusson TE: Development of occlusal traits and dental arch space from adolescence to adulthood: a 25-year follow-up study of 245 untreated subjects. Am J Orthod Dentofacial Orthop; 2009 Apr;135(4):456-62
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  • [Title] Development of occlusal traits and dental arch space from adolescence to adulthood: a 25-year follow-up study of 245 untreated subjects.
  • All subjects were orthodontically untreated, and all had the full complement of teeth at both examinations.
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Dental Occlusion. Dentition, Mixed. Dentition, Permanent. Female. Humans. Iceland / epidemiology. Longitudinal Studies. Male. Reference Values. Young Adult

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  • (PMID = 19361731.001).
  • [ISSN] 1097-6752
  • [Journal-full-title] American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
  • [ISO-abbreviation] Am J Orthod Dentofacial Orthop
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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87. Collins LC, Tamimi RM, Baer HJ, Connolly JL, Colditz GA, Schnitt SJ: Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses' Health Study. Cancer; 2005 May 1;103(9):1778-84
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  • [Title] Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy: results from the Nurses' Health Study.
  • [MeSH-minor] Adult. Biopsy. Case-Control Studies. Cell Nucleus / pathology. Cohort Studies. Female. Humans. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasms / diagnosis. Neoplasms / therapy. Retrospective Studies. Risk Factors. Time Factors. Treatment Outcome

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 15770688.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA046475; United States / NCI NIH HHS / CA / CA050385; United States / NCI NIH HHS / CA / CA087969
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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88. Hüppe D, Zehnter E, Mauss S, Böker K, Lutz T, Racky S, Schmidt W, Ullrich J, Sbrijer I, Heyne R, Schober A, John C, Hey KH, Bokemeyer B, Kallinowski B, Möller B, Pape S, Gutmann M, Alshuth U, Niederau C: [Epidemiology of chronic hepatitis C in Germany--an analysis of 10,326 patients in hepatitis centres and outpatient units]. Z Gastroenterol; 2008 Jan;46(1):34-44
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  • Using online data entry, various characteristics of 10,326 untreated patients with CHC were documented from March 2003 until May 2006 in 352 centres all over Germany.
  • [MeSH-minor] Adult. Age Factors. Aged. Female. Genotype. Germany / epidemiology. HIV Infections / epidemiology. Hepatitis B / epidemiology. Humans. Male. Middle Aged. Prospective Studies. Quality of Life. Socioeconomic Factors. Substance Abuse, Intravenous / complications. Time Factors. Unemployment

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  • (PMID = 18188814.001).
  • [ISSN] 0044-2771
  • [Journal-full-title] Zeitschrift für Gastroenterologie
  • [ISO-abbreviation] Z Gastroenterol
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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89. Rothenhäusler HB: [Mental disorders in general hospital patients]. Psychiatr Danub; 2006 Dec;18(3-4):183-92
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  • One follow-up study of long-term acute respiratory distress syndrome (ARDS) survivors using the Structural Clinical Interview for the DSM-IV (SCID) has shown that 43.5% of these patients met the criteria for a full posttraumatic stress disorder (PTSD), 8.9% of these patients for a subthreshold or partial PTSD (sub-PTSD) at hospital discharge, and 23.9% of them still suffered from full PTSD, 17.8% of them from sub-PTSD.
  • The duration of intensive care treatment, the number of medical complications, and the occurrence of acute rejection were positively correlated with the risk of PTSD symptoms subsequent to OLT.
  • Short-term consequences of cardiac surgery included adjustment disorders with depressed features (32.4%), acute full in-hospital PTSD (17.6%), and in-hospital major depression (17.6%).
  • If they are untreated, PTSD symptoms such as intrusive recollections, avoidance and hyper-arousal may impair the patients; quality of life more than the primary disease.
  • [MeSH-minor] Adjustment Disorders / diagnosis. Adjustment Disorders / epidemiology. Adjustment Disorders / psychology. Alcoholism / diagnosis. Alcoholism / epidemiology. Alcoholism / psychology. Austria. Cardiopulmonary Bypass / psychology. Cardiopulmonary Bypass / statistics & numerical data. Comorbidity. Critical Care / psychology. Cross-Sectional Studies. Dementia / diagnosis. Dementia / epidemiology. Dementia / psychology. Depressive Disorder / diagnosis. Depressive Disorder / epidemiology. Depressive Disorder / psychology. Humans. Liver Transplantation / psychology. Liver Transplantation / statistics & numerical data. Quality of Life / psychology. Referral and Consultation / statistics & numerical data. Respiratory Distress Syndrome, Adult / epidemiology. Respiratory Distress Syndrome, Adult / psychology. Risk Factors. Stress Disorders, Post-Traumatic / diagnosis. Stress Disorders, Post-Traumatic / epidemiology. Stress Disorders, Post-Traumatic / psychology


90. Isley WL, Harris WS, Miles JM: The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus. Metabolism; 2006 Jun;55(6):758-62
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  • We measured nocturnal and postprandial plasma palmitate concentrations and rate of appearance (R(a)) on 2 occasions in 12 obese dyslipidemic subjects with type 2 diabetes mellitus, using a single-blind, crossover format (placebo followed by simvastatin, 80 mg/d), and also on 1 occasion in 6 untreated control subjects.
  • [MeSH-minor] Adult. Cross-Over Studies. Female. Humans. Male. Middle Aged. Palmitates / blood. Single-Blind Method. Triglycerides / blood

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  • (PMID = 16713435.001).
  • [ISSN] 0026-0495
  • [Journal-full-title] Metabolism: clinical and experimental
  • [ISO-abbreviation] Metab. Clin. Exp.
  • [Language] eng
  • [Publication-type] Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids, Nonesterified; 0 / Palmitates; 0 / Triglycerides; AGG2FN16EV / Simvastatin
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91. Bharti AC, Panigrahi A, Sharma PK, Gupta N, Kumar R, Shukla S, Bhowmik DM, Agarwal SK, Guleria S, Mehra NK: Clinical relevance of curcumin-induced immunosuppression in living-related donor renal transplant: an in vitro analysis. Exp Clin Transplant; 2010 Jun;8(2):161-71
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  • RESULTS: Patients experiencing acute rejection exhibited a high level of interferon-alpha (38.3% +/- 11.2%) and a low level of interleukin 4 (4.2% +/- 2.0%) in their activated peripheral blood lymphocytes.
  • The use of curcumin dose-dependently decreased interferon-alpha induction in cultures from healthy controls (28.1% +/- 4.8%-10.7% +/- 5.3%, P < .001), patients experiencing acute rejection (38.3%-18.3%, P < .001), and those experiencing chronic rejection (40.6%-12.9%, P = .01) when compared with corresponding untreated cultures.
  • We also noted the synergistic inhibitory effect of in vitro treatment with curcumin in combination with cyclosporine on the peripheral blood lymphocytes of patients experiencing acute rejection.
  • [MeSH-minor] Acute Disease. Adult. Case-Control Studies. Cells, Cultured. Chronic Disease. Cyclosporine / pharmacology. Dose-Response Relationship, Drug. Female. Flow Cytometry. Humans. India. Interferon-gamma / metabolism. Interleukin-4 / metabolism. Male. Middle Aged. Mitogens / pharmacology. NF-kappa B / metabolism. Tetradecanoylphorbol Acetate / pharmacology. Time Factors. Young Adult

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  • (PMID = 20565374.001).
  • [ISSN] 2146-8427
  • [Journal-full-title] Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
  • [ISO-abbreviation] Exp Clin Transplant
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / IL4 protein, human; 0 / Immunosuppressive Agents; 0 / Mitogens; 0 / NF-kappa B; 207137-56-2 / Interleukin-4; 82115-62-6 / Interferon-gamma; 83HN0GTJ6D / Cyclosporine; IT942ZTH98 / Curcumin; NI40JAQ945 / Tetradecanoylphorbol Acetate
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92. Hemaprasanth KP, Raghavendra A, Singh R, Sridhar N, Raghunath MR: Efficacy of doramectin against natural and experimental infections of Lernaea cyprinacea in carps. Vet Parasitol; 2008 Oct 1;156(3-4):261-9
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  • Intramuscular administration of doramectin at 200microg/kgb.wt. of fish effectively removed adult Lernaea infection in L. fimbriatus as early as 18 days of treatment as compared to the time period of 43 days taken by the untreated fish to get rid of the infection.

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  • (PMID = 18650018.001).
  • [ISSN] 0304-4017
  • [Journal-full-title] Veterinary parasitology
  • [ISO-abbreviation] Vet. Parasitol.
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 117704-25-3 / doramectin; 70288-86-7 / Ivermectin
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93. Fabris C, Smirne C, Toniutto P, Colletta C, Rapetti R, Minisini R, Falleti E, Leutner M, Pirisi M: Usefulness of six non-proprietary indirect markers of liver fibrosis in patients with chronic hepatitis C. Clin Chem Lab Med; 2008;46(2):253-9
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  • METHODS: A total of 167 consecutive, hepatitis C virus RNA positive, untreated patients with chronic hepatitis C were studied.

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  • (PMID = 18324909.001).
  • [ISSN] 1434-6621
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers
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94. Chmela J, Mazánek L, Nakládal Z, Pesáková L, Halirová R: [Effectiveness of aerial application of VectoBac G larvicide granules against mosquitoes in the Olomouc region in spring 2006]. Epidemiol Mikrobiol Imunol; 2007 Apr;56(2):78-87
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  • In the floodplain forests, as expected, mass occurrence of adult mosquitoes was observed, infesting the nearby villages.
  • As a result, mosquitoes from the untreated breeding grounds caused an emergency in the nearby communities where insecticide aerosols had to be applied on a large scale, even repeatedly in some cases.

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  • (PMID = 17593805.001).
  • [ISSN] 1210-7913
  • [Journal-full-title] Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceské lékarské spolecnosti J.E. Purkyne
  • [ISO-abbreviation] Epidemiol Mikrobiol Imunol
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
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95. Taschner CA, Gieseke J, Le Thuc V, Rachdi H, Reyns N, Gauvrit JY, Leclerc X: Intracranial arteriovenous malformation: time-resolved contrast-enhanced MR angiography with combination of parallel imaging, keyhole acquisition, and k-space sampling techniques at 1.5 T. Radiology; 2008 Mar;246(3):871-9
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  • Twenty-eight patients (15 male, 13 female; mean age, 38.6 years; age range, 16-61 years) with 29 previously diagnosed, untreated intracranial AVMs who were referred for stereotactic gamma knife radiosurgery were evaluated.
  • [MeSH-minor] Adolescent. Adult. Angiography, Digital Subtraction. Contrast Media. Female. Humans. Image Processing, Computer-Assisted. Male. Meglumine. Middle Aged. Observer Variation. Organometallic Compounds

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  • [Copyright] (c) RSNA, 2008.
  • (PMID = 18195381.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Organometallic Compounds; 0 / gadoterate meglumine; 6HG8UB2MUY / Meglumine
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96. Wann BP, Bah TM, Boucher M, Courtemanche J, Le Marec N, Rousseau G, Godbout R: Vulnerability for apoptosis in the limbic system after myocardial infarction in rats: a possible model for human postinfarct major depression. J Psychiatry Neurosci; 2007 Jan;32(1):11-6
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  • Previously, we found early intracellular signalling changes in the limbic system after acute MI in rats.
  • The aim of the present study was to test the presence of behavioural deficits compatible with animal models of depression after acute MI in rats and to verify whether this is associated with apoptosis vulnerability markers.
  • METHODS: Occlusion of the left-anterior descending artery was induced for 40 minutes under anesthesia in adult male Sprague-Dawley rats.
  • RESULTS: Untreated MI rats drank significantly less sucrose and swam significantly less than sham rats.

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  • (PMID = 17245469.001).
  • [ISSN] 1180-4882
  • [Journal-full-title] Journal of psychiatry & neuroscience : JPN
  • [ISO-abbreviation] J Psychiatry Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antidepressive Agents, Tricyclic; TG537D343B / Desipramine
  • [Other-IDs] NLM/ PMC1764546
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97. Meyer T, Caplin ME, Palmer DH, Valle JW, Larvin M, Waters JS, Coxon F, Borbath I, Peeters M, Nagano E, Kato H: A phase Ib/IIa trial to evaluate the CCK2 receptor antagonist Z-360 in combination with gemcitabine in patients with advanced pancreatic cancer. Eur J Cancer; 2010 Feb;46(3):526-33
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  • METHODS: Previously untreated patients with PC were randomly allocated to Z-360 120 mg, 240 mg or placebo.
  • [MeSH-minor] Adult. Aged. Benzodiazepinones / administration & dosage. Benzodiazepinones / adverse effects. Benzodiazepinones / blood. Deoxycytidine / administration & dosage. Deoxycytidine / adverse effects. Deoxycytidine / analogs & derivatives. Deoxycytidine / blood. Female. Gastrins / blood. Humans. Male. Middle Aged. Quality of Life. Severity of Illness Index. Survival Analysis. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 20006921.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzodiazepinones; 0 / Gastrins; 0 / Receptor, Cholecystokinin B; 0 / Z-360; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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98. Dinh P, Bhatia N, Rasouli A, Suryadevara S, Cahill K, Gupta R: Transplantation of preconditioned Schwann cells following hemisection spinal cord injury. Spine (Phila Pa 1976); 2007 Apr 20;32(9):943-9
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  • METHODS: Adult Sprague-Dawley rats (n = 24) were used to create a hemisection injury of the spinal cord.
  • Peripheral nerve grafts were obtained from rat sciatic nerve, either untreated or subjected to mechanical compression for 2 weeks with nonconstrictive tubing.

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  • (PMID = 17450067.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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99. Wahl K, Kordon A, Kuelz KA, Voderholzer U, Hohagen F, Zurowski B: Obsessive-Compulsive Disorder (OCD) is still an unrecognised disorder: a study on the recognition of OCD in psychiatric outpatients. Eur Psychiatry; 2010 Nov;25(7):374-7
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  • CONCLUSIONS: In outpatient clinics over 70% of OCD patients remain unrecognised and thus untreated by consultants.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male. Mass Screening. Middle Aged. Outpatients. Psychiatric Status Rating Scales. Surveys and Questionnaires


100. Perri F, Bellini M, Portincasa P, Parodi A, Bonazzi P, Marzio L, Galeazzi F, Usai P, Citrino A, Usai-Satta P: (13)C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer): Toward standardization for testing gastric emptying of solids. Dig Liver Dis; 2010 Aug;42(8):549-53
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  • Patients with diabetic gastroparesis and untreated celiac disease with known gastric motility disorders were also tested with the new labelled muffin.
  • Mean (+/-standard deviation) t(1/2) values were 179+/-50min in patients with diabetic gastroparesis (n=8) and 151+/-20min in those with untreated celiac disease (n=11) (p<or=0.001 vs controls).
  • [MeSH-minor] Adult. Caprylates. Carbon Isotopes. Celiac Disease / complications. Celiac Disease / physiopathology. Diabetic Neuropathies / complications. Diabetic Neuropathies / physiopathology. Diagnostic Techniques, Digestive System / standards. Eating. Female. Food. Gastric Emptying. Humans. Male. Middle Aged

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  • [Copyright] Copyright 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20116352.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Caprylates; 0 / Carbon Isotopes; 124-07-2 / octanoic acid
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