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1. Koda T, Morita M, Imai H: Retinoic acid inhibits uterotrophic activity of bisphenol A in adult ovariectomized rats. J Nutr Sci Vitaminol (Tokyo); 2007 Oct;53(5):432-6
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  • [Title] Retinoic acid inhibits uterotrophic activity of bisphenol A in adult ovariectomized rats.
  • Proliferated and apoptotic uterine cells were identified by 5-bromo-2'deoxyuridine (BrdU) incorporation and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay.
  • We observed that ATRA supplementation significantly inhibits a BPA-induced uterine weight increase in adult ovariectomized rats.
  • However, there were no significant differences in the increases in the numbers of BrdU-positive cells and TUNEL-positive cells between the BPA and BPA+ATRA groups.

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  • (PMID = 18079610.001).
  • [ISSN] 0301-4800
  • [Journal-full-title] Journal of nutritional science and vitaminology
  • [ISO-abbreviation] J. Nutr. Sci. Vitaminol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzhydryl Compounds; 0 / Free Radical Scavengers; 0 / Phenols; 5688UTC01R / Tretinoin; G34N38R2N1 / Bromodeoxyuridine; MLT3645I99 / bisphenol A
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2. Zhen HN, Zhang X, Hu PZ, Yang TT, Fei Z, Zhang JN, Fu LA, He XS, Ma FC, Wang XL: Survivin expression and its relation with proliferation, apoptosis, and angiogenesis in brain gliomas. Cancer; 2005 Dec 15;104(12):2775-83
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  • Apoptotic cells of brain glioma were screened by TdT-mediated dUTP nick end-labeling (TUNEL), and survivin immunoreactivity score (IRS), proliferative index (PI), apoptotic index (AI), overall daily growth (ODG), and microvessel density (MVD) in brain gliomas were measured.
  • PI, ODG, and MVD in the survivin-positive group were significantly higher than those in the survivin-negative group (P < 0.001 for all).
  • Although there was no significant difference between AI in the survivin-positive group or in the survivin-negative group (P = 0.108), AI was inversely correlated with survivin IRS (P = 0.005).
  • [MeSH-minor] Adult. Aged. Apoptosis / physiology. Biomarkers, Tumor / analysis. Biopsy, Needle. Cell Proliferation. Cohort Studies. Disease Progression. Female. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Inhibitor of Apoptosis Proteins. Male. Middle Aged. Neovascularization, Pathologic. Predictive Value of Tests. Sampling Studies. Sensitivity and Specificity


3. Florell SR, Bowen AR, Hanks AN, Murphy KJ, Grossman D: Proliferation, apoptosis, and survivin expression in a spectrum of melanocytic nevi. J Cutan Pathol; 2005 Jan;32(1):45-9
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  • Apoptotic and proliferation indices were calculated by counting immunoreactive cells in terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling and proliferating cell nuclear antigen immunostained sections, respectively.
  • The proliferative index was highest for Spitz nevi, while all other nevi demonstrated rare positive cells.

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  • (PMID = 15660660.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] ENG
  • [Grant] United States / NIAMS NIH HHS / AR / AR050102-02; United States / NIAMS NIH HHS / AR / K08 AR048618; United States / NCRR NIH HHS / RR / K23RR17525; United States / NCRR NIH HHS / RR / K23 RR017525; United States / NIAMS NIH HHS / AR / R01 AR050102; United States / NIAMS NIH HHS / AR / R01 AR050102-02; United States / NIAMS NIH HHS / AR / KO8AR48618
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS44268; NLM/ PMC2292117
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4. Kreft A, Holtmann H, Schad A, Kirkpatrick CJ: Detection of residual leukemic blasts in adult patients with acute T-lymphoblastic leukemia using bone marrow trephine biopsies: comparison of fluorescent immunohistochemistry with conventional cytologic and flow-cytometric analysis. Pathol Res Pract; 2010 Aug 15;206(8):560-4
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  • [Title] Detection of residual leukemic blasts in adult patients with acute T-lymphoblastic leukemia using bone marrow trephine biopsies: comparison of fluorescent immunohistochemistry with conventional cytologic and flow-cytometric analysis.
  • Evaluation of remission in adult acute lymphoblastic leukemia (ALL) normally relies on cytologic evaluation and flow-cytometric analysis.
  • Double fluorescent immunostaining with TdT and CD3 was performed.
  • In 17 of 26 investigations, the results were concordant (either positive or negative).
  • [MeSH-major] Bone Marrow / pathology. Flow Cytometry. Fluorescent Antibody Technique. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Cell Separation. Cytological Techniques. Female. Humans. Male. Middle Aged. Sensitivity and Specificity. Young Adult

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  • (PMID = 20413226.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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5. Kobayashi Y, Fujii Y, Yano M, Sasaki H, Yukiue H, Haneda H, Suzuki E, Endo K, Kawano O: Preoperative steroid pulse therapy for invasive thymoma: clinical experience and mechanism of action. Cancer; 2006 May 1;106(9):1901-7
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  • TdT-mediated dUTP-biotin nick-end labeling (TUNEL) staining was used to analyze the apoptotic lymphocytes and epithelial cells.
  • The reduction in tumor size was accompanied with a marked reduction in the CD4+8+ double-positive immature thymocytes that expressed higher levels of glucocorticoid receptor.
  • CONCLUSIONS: The efficiency of preoperative steroid pulse therapy in type B1 thymoma was most prominent, which is probably related to the specific effect on GR-rich CD4+8+ double-positive immature lymphocytes, which are abundant in this type of thymoma.
  • [MeSH-minor] Adult. Aged. Antigens, CD4 / analysis. Antigens, CD8 / analysis. Combined Modality Therapy. Female. Flow Cytometry. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 16598701.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD4; 0 / Antigens, CD8; 0 / Glucocorticoids
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6. Nelson BP, Treaba D, Goolsby C, Williams S, Dewald G, Gordon L, Peterson LC: Surface immunoglobulin positive lymphoblastic leukemia in adults; a genetic spectrum. Leuk Lymphoma; 2006 Jul;47(7):1352-9
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  • [Title] Surface immunoglobulin positive lymphoblastic leukemia in adults; a genetic spectrum.
  • Precursor B-lymphoblastic leukemia is typically surface immunoglobulin (sIg) negative.
  • Although rare cases of sIg+ precursor lymphoblastic leukemia are recognized, sIg+ leukemia often represent leukemic phase of Burkitt lymphoma or other non-Hodgkin lymphoma such as blastic mantle cell lymphoma.
  • This study reports four adults, two women (56 and 58 years old) and two men (35 and 41 years old) with lymphoblastic leukemia that displayed lambda, surface immunoglobulin restriction (sIg+).
  • The leukemic cells were all dim CD45 positive with side scatter light characteristic of blasts.
  • Two cases were positive with the blasts associated with antigens TdT and CD34.
  • Genetic abnormalities were detected in all cases and in three cases included abnormalities commonly present in precursor lymphoblastic leukemia.
  • Deletion of the 3' region of the mixed lineage leukemia (MLL) gene at chromosome 11q23 as well as t(14;18) were detected in the second case.
  • Deletion of the 3' region of the mixed lineage leukemia (MLL) gene at chromosome 11q23 as well as t(14;18) were detected in one case.
  • These cases illustrate that lymphoblastic leukemias occurring in adults exhibit a morphologic, immunophenotypic as well as a genetic spectrum and represent either non-Hodgkin lymphoma or precursor lymphoblastic leukemia.
  • [MeSH-major] Immunoglobulins / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism. Translocation, Genetic
  • [MeSH-minor] Adult. Biopsy. Bone Marrow / metabolism. Burkitt Lymphoma / metabolism. Female. Gene Deletion. Humans. Immunohistochemistry. Immunophenotyping / methods. Male. Middle Aged

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  • (PMID = 16923568.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulins
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7. Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H, Skondra D, Miyahara S, Sobrin L, Thomas KL, Chen DF, Grosskreutz CL, Hafezi-Moghadam A, Miller JW: Characterization of cytokine responses to retinal detachment in rats. Mol Vis; 2006;12:867-78
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  • METHODS: RD was induced in adult rats by subretinal injection of sodium hyaluronate.
  • To assess the potential of early response genes after RD to induce photoreceptor degeneration, exogenous recombinant proteins were subretinally injected and the photoreceptor cell death was assessed using a TdT-dUTP terminal nick-end labeling (TUNEL) assay at 24 h after RD.
  • Subretinal administration of MCP-1 significantly increased TUNEL-positive cells in the ONL 24 h after RD, while injection of vehicle control, TNF-alpha, or IL-1beta showed no effect.

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  • (PMID = 16917487.001).
  • [ISSN] 1090-0535
  • [Journal-full-title] Molecular vision
  • [ISO-abbreviation] Mol. Vis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ccl2 protein, rat; 0 / Chemokine CCL2; 0 / Interleukin-1; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; 103107-01-3 / Fibroblast Growth Factor 2
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8. Wolf E, Harms H, Winkler J, Reulbach U, Kirchner T, Niedobitek G, Baumann I: Terminal deoxynucleotidyl transferase-positive cells in trephine biopsies following bone marrow or peripheral stem cell transplantation reflect vigorous B-cell generation. Histopathology; 2005 Apr;46(4):442-50
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  • [Title] Terminal deoxynucleotidyl transferase-positive cells in trephine biopsies following bone marrow or peripheral stem cell transplantation reflect vigorous B-cell generation.
  • While in early childhood a high number of B-cell precursors is found in the bone marrow, only very few such cells are usually detectable in adult bone marrow.
  • To assess the number of immature B cells present after haematopoietic cell transplantation the number of terminal deoxynucleotidyl transferase (TdT)-positive cells in regenerating bone marrow of adult patients was analysed.
  • Specimens from 11 untransplanted adult patients and 11 infants were also studied, as negative and positive controls, respectively.
  • Immunohistochemistry was performed on paraffin-embedded bone marrow biopsy sections using TdT as a marker of lymphoid progenitors.
  • Using computer-assisted automated image analysis we quantitatively assessed the TdT+ cells present.
  • We found a significant increase in the numbers of B-cell precursors in the bone marrow after allogeneic and autologous BMT/SCT compared with adult controls (P = 0.022).
  • However, the median number of TdT+ B cells after BMT/SCT was significantly lower than the number of equivalent B cells in infantile bone marrow biopsy specimens (P < 0.001).
  • CONCLUSIONS: Bone marrow of adult patients after BMT/SCT is capable of initiating vigorous precursor B-cell generation, which is not seen in untransplanted adults.
  • Only in two young adult patients did it reach the magnitude of B-cell generation seen in infantile bone marrow where immunocompetent B cells are produced normally.
  • A marked increase in number of immature B cells post-transplant may mimic B-cell acute lymphoblastic leukaemia (B-ALL).
  • [MeSH-minor] Adult. Aged. Biopsy. Bone Marrow / pathology. Child. Child, Preschool. Humans. Infant. Leukemia / pathology. Leukemia / therapy. Lymphocyte Count. Lymphoma / pathology. Lymphoma / therapy. Lymphopoiesis. Middle Aged. Myelodysplastic Syndromes / pathology. Myelodysplastic Syndromes / therapy. Time Factors. Transplantation, Homologous

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  • (PMID = 15810956.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.7.31 / DNA Nucleotidylexotransferase
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9. Ehrig T, Billings SD, Fanburg-Smith JC: Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity? Ann Diagn Pathol; 2007 Jun;11(3):153-9
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  • One case studied was positive for Fli-1.
  • All were negative for leukocyte common antigen, Tdt, CD3, CD20, CD79, CK20, pankeratin, epithelial membrane antigen, chromogranin, neurofilament protein, carcinoembryonic antigen, desmin, actin, diffuse S100 protein, and HMB45.
  • Nine cases with material for reverse transcription-polymerase chain reaction revealed 1 positive type 2 translocation (EWS exon 7 to Fli-1 exon 5), 4 negative, and 4 "unable to amplify."
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD / genetics. Antigens, CD / metabolism. Cell Adhesion Molecules / genetics. Cell Adhesion Molecules / metabolism. Child. Child, Preschool. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Sex Characteristics. Vimentin / genetics. Vimentin / metabolism

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  • (PMID = 17498589.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Vimentin
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10. Wang JF, Wang YZ, Chen ZW, Taylor RC: [Prevalence of lymphoma subtypes in Shanxi according to latest WHO classification]. Zhonghua Bing Li Xue Za Zhi; 2006 Apr;35(4):218-23
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  • Immunohistochemical study was performed using a panel of antibodies, including ALK1, bcl-6, CD (1a, 3, 4, 5, 7, 8, 10, 15, 20, 23, 30, 43, 56, 68, 79a and 99), cyclin D1, EMA, IgD, kappa, lambda, LMP1, PAX5, TdT and Vs38C.
  • As for the subtyping of NHL, diffuse large B-cell lymphoma was commonest (35.1%), followed by peripheral T-cell lymphoma, NOS (12.0%), extranodal marginal zone B-cell lymphoma (MALT lymphoma) (11.7%), follicular lymphoma (8.6%), T-lymphoblastic lymphoma (7.0%), anaplastic large cell lymphoma (4.2%), B-small lymphocytic lymphoma (3.6%) and mantle cell lymphoma (2.6%).
  • Regarding markers for EB virus infection, 14 cases of the B-cell lymphoma gave positive findings with both EBER in-situ hybridization and LMP-1 immunohistochemistry, while 6 of the T/NK-cell lymphoma expressed LMP-1 and 19 showed positive signals for EBER.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. China / epidemiology. Female. Humans. Immunohistochemistry. Infant. Lymphoma, Follicular / epidemiology. Lymphoma, Large B-Cell, Diffuse / epidemiology. Lymphoma, Large B-Cell, Diffuse / pathology. Male. Middle Aged. Prevalence. Young Adult


11. Oshitari T, Yoshida-Hata N, Yamamoto S: Effect of neurotrophic factors on neuronal apoptosis and neurite regeneration in cultured rat retinas exposed to high glucose. Brain Res; 2010 Jul 30;1346:43-51
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  • The retinas of six adult Sprague-Dawley rats were studied.
  • Then, the explants were fixed, cryosectioned, and stained by TdT-dUTP terminal nick-end labeling (TUNEL), and also immunostained for the active-forms of caspase-3 and -9.
  • The numbers of TUNEL-positive and caspase-3 and -9-immunopositive cells in the ganglion cell layer (GCL) were significantly higher, and the number of regenerating neurites was significantly lower in retinas cultured in HGM than in NG medium.
  • Retinas incubated in HGM supplemented with BDNF, NT-4, or citicoline had significantly lower numbers of TUNEL-positive and caspase-3 and -9-immunopositive cells in the GCL, and the numbers of regenerating neurites were significantly higher than in HGM without these factors.

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20573599.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Nerve Growth Factors; 9007-34-5 / Collagen; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 9; IY9XDZ35W2 / Glucose
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12. Liu HY, Yin HL, DU J, Cai Y, Lu ZF, Zhou HB, Zhou XJ: [Clinicopathologic features of granulocytic sarcoma: a study of 38 cases]. Zhonghua Bing Li Xue Za Zhi; 2010 Mar;39(3):172-6
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  • Most cases were also positive for CD68, lysozyme, CD99 and TdT.
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, CD43 / metabolism. Burkitt Lymphoma / metabolism. Burkitt Lymphoma / pathology. Child. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Lymph Nodes / pathology. Male. Middle Aged. Peroxidase / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Retrospective Studies. Sarcoma, Ewing / metabolism. Sarcoma, Ewing / pathology. Survival Rate. Young Adult

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  • (PMID = 20450763.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD43; EC 1.11.1.7 / Peroxidase
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13. Arroyo JG, Yang L, Bula D, Chen DF: Photoreceptor apoptosis in human retinal detachment. Am J Ophthalmol; 2005 Apr;139(4):605-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Retinal tissue fragments excised during the course of vitreous surgery for RD and recurrent RD were frozen, cut into 4-mum sections, and analyzed using a TdT-dUTP terminal nick-end labeling assay for cell apoptosis.
  • All retinal tissue specimens had TUNEL-positive cells localized to the outer nuclear layer of the retina, consistent with the localization of photoreceptor cell bodies.
  • TUNEL-positive cells were first identified at 24 hours, peaked by 2 days, and dropped to a low level by 7 days after RD.
  • Recurrent RD induced a greater number of TUNEL-positive cells/mm(2) in the ONL compared with primary RD at corresponding timepoints after the onset of RD.
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Nucleus / pathology. Female. Humans. In Situ Nick-End Labeling. Male. Middle Aged. Prospective Studies. Recurrence. Time Factors

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  • [CommentIn] Am J Ophthalmol. 2006 Jan;141(1):227; author reply 227-8 [16387019.001]
  • (PMID = 15808154.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / K-23
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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14. Shin SY, Lee YJ: Conjunctival changes induced by LASIK suction ring in a rabbit model. Ophthalmic Res; 2006;38(6):343-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A suction ring was applied to adult albino rabbit eyes (n = 30) with a vacuum pressure of 508 mm Hg for 40 s.
  • TdT-dUTP-terminal nick-end labeling (TUNEL) assay and immunohistochemical staining for p65 were also performed.
  • At all time points, conjunctival epithelium showed no positive staining for p65.

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  • [Copyright] Copyright 2006 S. Karger AG, Basel.
  • (PMID = 17047406.001).
  • [ISSN] 0030-3747
  • [Journal-full-title] Ophthalmic research
  • [ISO-abbreviation] Ophthalmic Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Mucins; 0 / Synaptotagmin I; P4448TJR7J / Alcian Blue
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15. Brcić I, Labar B, Perić-Balja M, Basić-Kinda S, Nola M: Terminal deoxynucleotidyl transferase negative T-cell lymphoblastic lymphoma in aleukemic patient. Int J Hematol; 2008 Sep;88(2):189-91
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  • [Title] Terminal deoxynucleotidyl transferase negative T-cell lymphoblastic lymphoma in aleukemic patient.
  • Precursor lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) is a malignant neoplasm of precursor lymphocytes of T- or B-cell phenotype.
  • Immunohistochemical studies revealed that the tumor cells were positive for CD3, CD34 class II, CD10, CD79a and CD99 but negative for TdT.
  • Even though TdT was negative, he received ALL-therapy and is now in remission.
  • [MeSH-major] Biomarkers, Tumor / metabolism. DNA Nucleotidylexotransferase / metabolism. Lymph Nodes / pathology. Lymphatic Diseases / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • [MeSH-minor] Adult. Biopsy. Bone Marrow Cells / cytology. Humans. Male. Remission Induction

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  • (PMID = 18512118.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.7.31 / DNA Nucleotidylexotransferase
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16. Yaar R, Rothman K, Mahalingam M: When dead cells tell tales-cutaneous involvement by precursor T-cell acute lymphoblastic lymphoma with an uncommon phenotype. Am J Dermatopathol; 2010 Apr;32(2):183-6
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  • [Title] When dead cells tell tales-cutaneous involvement by precursor T-cell acute lymphoblastic lymphoma with an uncommon phenotype.
  • The thymic type of precursor T-cell acute lymphoblastic lymphoma (pre-T ALL), an uncommon T-cell malignancy, typically presents as a thymic mass and expresses terminal deoxonucleotidyl transferase, CD7, and cytoplasmic CD3, with variable expression of other markers.
  • Microscopic examination of both lesions revealed a moderate to dense pandermal infiltrate of medium-sized lymphocytes with extensive "crush" artifact, whereas immunohistochemistry revealed positive staining of lesional cells for CD45, CD3, Bcl-2, Ki-67, CD5, CD7, and CD34 but negative staining for CD4, CD8, CD30, CD56, CD10, CD117, anaplastic lymphoma kinase protein, TdT, myeloperoxidase, CD79a, and CD20.
  • Features unique to this case include the cutaneous presentation and the immunophenotype-absence of CD4, CD8, and TdT with expression of CD34-both highly unusual features for pre-T ALL.
  • [MeSH-major] Phenotype. Precancerous Conditions / pathology. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology. Skin / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD3 / metabolism. Antigens, CD34 / metabolism. Antigens, CD7 / metabolism. Biopsy. Face. Humans. Male. Necrosis

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  • (PMID = 20010405.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD34; 0 / Antigens, CD7
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17. Yu B, Du JR, Xie JL, Yu R, Zheng XD, Zhu H, Zhou XG: [Clinicopathologic study of 128 cases of T-lymphoblastic lymphoma/leukemia]. Zhonghua Bing Li Xue Za Zhi; 2010 Jul;39(7):452-7
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  • [Title] [Clinicopathologic study of 128 cases of T-lymphoblastic lymphoma/leukemia].
  • OBJECTIVE: To clarify clinical and morphological features and immunophenotype of T lymphoblastic lymphoma/leukaemia (T-LBL/ALL) and to further improve the knowledge and diagnostic accuracy for T-ALL/LBL.
  • Tumor cells expressed TdT in 121/128 (94.5%) cases, CD34 in 48/98 (49.0%) cases, CD3 in 78/108 (72.2%) cases, CD7 in 104/108 (96.3%) cases, CD43 in 56/63 (88.9%) cases, CD79a in 5/70 (7.1%) cases, CD10 in 25/76 (32.9%) cases, CD99 in 58/60 (96.7%) cases and Pax-5 in 4/91(4.4%) cases.
  • Under a similar condition of carrying a positive staining result on CD3 in tumor cells, there was a statistically significant difference between patients in the group of over 30 of age and that with the age ranging from 11 to 30.
  • Patients associating with a CD10 positive staining of tumor cells showed also a shorter survival period.
  • Immunohistochemistry staining particularly adoption of CD7, Pax-5, TdT, CD34 and Ki-67 stainings in combination are helpful of making a diagnosis for T-LBL/ALL.
  • [MeSH-major] Antigens, CD3 / metabolism. Gene Rearrangement, T-Lymphocyte. Neprilysin / metabolism. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antigens, CD34 / metabolism. Antigens, CD7 / metabolism. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. B-Cell-Specific Activator Protein / metabolism. Child. Child, Preschool. DNA Nucleotidylexotransferase / metabolism. Female. Follow-Up Studies. Humans. Ki-67 Antigen / metabolism. Lymphatic Metastasis. Male. Middle Aged. Survival Rate. Young Adult

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  • (PMID = 21055173.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD3; 0 / Antigens, CD34; 0 / Antigens, CD7; 0 / B-Cell-Specific Activator Protein; 0 / Ki-67 Antigen; 0 / PAX5 protein, human; EC 2.7.7.31 / DNA Nucleotidylexotransferase; EC 3.4.24.11 / Neprilysin
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18. Glamoclija V, Vilović K, Saraga-Babić M, Baranović A, Sapunar D: Apoptosis and active caspase-3 expression in human granulosa cells. Fertil Steril; 2005 Feb;83(2):426-31

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTERVENTION(S): Immunostaining of tissue sections and cell smears using antibody to active caspase-3 and terminal deoxynucleotidyl transferase (TdT) assay (TUNEL) for detection of internucleosomal DNA fragmentation.
  • MAIN OUTCOME MEASURE(S): Microscopic evaluation to assess the presence and cellular co-localization of active caspase-3 and TUNEL-positive cells.
  • Higher numbers of granulosa cells positive with caspase-3 than cells positive with TUNEL suggest an earlier activation of caspase-3 compared with the DNA fragmentation detected by TUNEL assay and also a longer detection period of caspase-3 than DNA fragmentation in apoptotic granulosa cells.
  • [MeSH-minor] Adult. Caspase 3. Female. Fertilization in Vitro. Gene Expression Regulation, Enzymologic. Humans. In Situ Nick-End Labeling. In Vitro Techniques

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  • (PMID = 15705385.001).
  • [ISSN] 0015-0282
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases
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19. Zhang HX, Li WQ, Zhang Y, Zhao JP, Lv LX, Yang G: [Association analysis of neuregulin 1 gene polymorphism with schizophrenia in Chinese Han population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2009 Feb;26(1):16-20
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  • The transmission disequilibrium test (TDT) program (Genehunter software 2.0) was used to evaluate the association of the NRG1 gene with schizophrenia.
  • In the positive subtype of parent-proband trios, C/T/G/C hapoltype transmission was not observed.
  • CONCLUSION: The NRG1 gene polymorphism is significantly associated with schizophrenia in Chinese Han, especially in the positive subtype of schizophrenia.
  • [MeSH-minor] Adolescent. Adult. Alleles. China. Female. Haplotypes / genetics. Humans. Linkage Disequilibrium. Male. Polymorphism, Single Nucleotide

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  • (PMID = 19199244.001).
  • [ISSN] 1003-9406
  • [Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
  • [ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neuregulin-1
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20. Zhen HN, Zhang X, Hu PZ, Fu LA, Yang TT, Ma FC, Wang XL, Liang JW: [Research on relationship of survivin gene expression with malignant proliferation and apoptosis of brain glioma]. Zhonghua Wai Ke Za Zhi; 2005 Jul 1;43(13):885-8
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  • Apoptotic cells were screened by TdT-mediated dUTP-biotin nick-end labeling (TUNEL) method, and the apoptotic index (AI) of brain glioma was calculated.
  • PI in survivin positive group was significantly higher than that in survivin negative group (P < 0.01), and PI was positively correlated with survivin IRS (r = 0.740, P < 0.01).
  • There was no significant difference between AI in survivin positive group and that in survivin negative group (P > 0.05), however, AI was negatively correlated with survivin IRS (r = -0.307, P < 0.01).
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Inhibitor of Apoptosis Proteins. Male. Middle Aged. Proliferating Cell Nuclear Antigen / biosynthesis


21. Lewis RE, Cruse JM, Sanders CM, Webb RN, Tillman BF, Beason KL, Lam J, Koehler J: The immunophenotype of pre-TALL/LBL revisited. Exp Mol Pathol; 2006 Oct;81(2):162-5
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  • Flow cytometric analysis of cluster of differentiation (CD) markers in abnormal lymphocyte populations is crucial in the diagnosis of precursor T cell acute lymphoblastic leukemia (T-ALL)/lymphoblastic lymphoma (LBL).
  • The World Health Organization (WHO) suggested immunophenotype for pre-T ALL/LBL typically includes the expression of TdT, cCD3, and CD7, while CD2, CD3, CD4, CD5, CD8, and CD10 are variably expressed.
  • The myeloid antigens CD13 and CD33 are usually positive, whereas CD117 and cCD79a are infrequently expressed.
  • Fifteen of 19 cases studied were evaluated for TdT, cCD3, and cCD79a expression.
  • Eleven (73.3%) positively expressed TdT, 15 (100%) positively expressed cCD3, and 9 (60%) positively expressed cCD79a.
  • Of the 17 cases analyzed for CD7, CD5, and CD10 expression, CD7 and CD5 were positive in all 17 (100%) cases, whereas CD10 was positive in 8 (47.1%) cases.
  • CD4 was positive in 11 (61.1%), and CD8 was expressed in 9 (50%).
  • [MeSH-major] Antigens, CD / metabolism. Immunophenotyping. Leukemia-Lymphoma, Adult T-Cell / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism

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  • (PMID = 16908018.001).
  • [ISSN] 0014-4800
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD
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22. Lee H, Park H, Kim YJ, Kim HJ, Ahn YM, Park B, Park JH, Lee BE: Expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in human preeclamptic placenta: possible implications in the process of trophoblast apoptosis. Placenta; 2005 Feb-Mar;26(2-3):226-33

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  • A significantly higher number of LOX-1 and M30-positive cells were found in preeclamptic placentas than in normal placentas.
  • The number of M30-positive cells correlated with the apoptotic index of trophoblasts determined by TdT-mediated dUTP nick-end labeling (TUNEL).
  • [MeSH-minor] Adult. Antibodies, Monoclonal. Blotting, Western. Caspases / metabolism. Cell Count. Female. Fluorescent Antibody Technique, Indirect. Humans. Immunoenzyme Techniques. In Situ Nick-End Labeling. Keratins / immunology. Keratins / metabolism. Pregnancy. Receptors, Oxidized LDL. Scavenger Receptors, Class E. Up-Regulation

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  • [Copyright] (c) Elsevier Ltd. All rights reserved.
  • (PMID = 15708124.001).
  • [ISSN] 0143-4004
  • [Journal-full-title] Placenta
  • [ISO-abbreviation] Placenta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / OLR1 protein, human; 0 / Receptors, LDL; 0 / Receptors, Oxidized LDL; 0 / Scavenger Receptors, Class E; 68238-35-7 / Keratins; EC 3.4.22.- / Caspases
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23. He Q, Li X, Tao Y, Liu YZ, Yang LP, Ying SX: [Expression of insulin-like growth factor receptor type I in marrow nucleated cells from hematologic malignancies and its anti-apoptotic effect]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2005 Jun;13(3):483-7
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  • To explore the expression of insulin-like growth factor receptor type I (IGF-IR) and its relationship to apoptosis in hematopoietic cells of MDS and AML marrow, bone marrow nucleated cells from 16 patients with myelodysplastic syndrome (MDS) and 16 patients with acute myeloid leukemia (AML) were collected for analysis, respectively.
  • Immunocytochemical method (APAAP) and TdT-mediated dUTP nick end labeling (TUNEL) fluorescence were used simultaneously on cytospins of nucleated cells from these patients.
  • Then, the ratios of IGF-IR positive cells and apoptosis cells in all nucleated cells were counted separately.
  • Also IGF-IR positive rate in AML marrow (86.8 +/- 13.8)% was significantly higher than that in normal marrow (P < 0.01).
  • (3) apoptosis occurred mainly in IGF-IR negative cells (9.0 +/- 4.8)% and less in IGF-IR positive cells (1.4 +/- 2.4)% (P < 0.01).
  • (5) IGF-IR positive rate in nucleated cells of MDS and AML marrow showed positive correlation with blast rate (r = 0.677; P < 0.01).

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  • (PMID = 15972147.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.10.1 / Receptor, IGF Type 1
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24. Valbuena JR, Admirand JH, Gualco G, Medeiros LJ: Myeloid sarcoma involving the breast. Arch Pathol Lab Med; 2005 Jan;129(1):32-8
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  • CONTEXT: Myeloid sarcoma is a neoplasm of myeloid cells that can arise before, concurrent with, or following acute myeloid leukemia.
  • Two patients presented with isolated tumors of the breast, with no history or subsequent development of acute myeloid leukemia.
  • In 3 patients, the breast tumors represented relapse of acute myeloid leukemia.
  • Naphthol AS-D chloroacetate esterase was positive in all 3 cases assessed.
  • Immunohistochemistry showed that myeloperoxidase (n = 5) and CD43 (n = 3) were positive, and CD3 (n = 5) and CD20 (n = 5) were negative in all cases assessed.
  • Lysozyme was positive in 4 (80%) of 5; CD117 was positive in 2 (67%) of 3; and single cases were positive for CD45 (1/3), TdT (1/2), CD79a, and the PAX5 gene product.
  • In the literature, as in this study, these tumors most often represent relapse or the initial presentation of acute myeloid leukemia.
  • However, 2 of the cases we report presented with isolated masses, without a history or subsequent development of acute myeloid leukemia at last follow-up.
  • [MeSH-minor] Acute Disease. Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Leukemia, Myeloid / diagnosis. Middle Aged. Recurrence. Skin Neoplasms / diagnosis. Splenic Neoplasms / diagnosis

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  • (PMID = 15628906.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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27. Chen B, Gao XQ, Yang CX, Tan SK, Sun ZL, Yan NH, Pang YG, Yuan M, Chen GJ, Xu GT, Zhang K, Yuan QL: Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats. Brain Res; 2009 Aug 11;1284:1-11
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  • Adult rats were subjected to two-hour middle cerebral artery occlusion and reperfusion, followed by infusion of NSCs (labeled with5-bromo-2'-deoxyuridine before infusion, BrdU), GDNF/NSCs and saline at 3 days after reperfusion (NSCs group, GDNF/NSCs group, control group), respectively.
  • TdT-mediated dUTP-biotin nick-end labeling (TUNEL) was employed to observe apoptotic cells.
  • In contrast, caspase-3 positive cells and TUNEL-positive cells in the GDNF/NSCs group were significantly decreased compared with NSCs group.

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  • [ErratumIn] Brain Res. 2010 Jan 13;1308:187
  • [ErratumIn] Brain Res. 2009 Nov 3;1296:234
  • (PMID = 19520066.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; 0 / Dlgh4 protein, rat; 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Intracellular Signaling Peptides and Proteins; 0 / Membrane Proteins; 0 / Synaptophysin; 9061-61-4 / Nerve Growth Factor
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28. Zuo Z, Lu WP, Yu JB, Li JM, Liao DY: [Extramedullary infiltration of acute monocytic leukemia/monoblastic sarcoma: a clinicopathologic and immunophenotype analysis of 5 cases]. Zhonghua Bing Li Xue Za Zhi; 2008 Jan;37(1):27-30
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  • [Title] [Extramedullary infiltration of acute monocytic leukemia/monoblastic sarcoma: a clinicopathologic and immunophenotype analysis of 5 cases].
  • OBJECTIVE: To study the clinicopathologic features, diagnosis and differential diagnosis of extramedullary infiltration of acute monocytic leukemia/monoblastic sarcoma.
  • METHODS: Five cases of extramedullary infiltration of acute monocytic leukemia/monoblastic sarcoma were selected from 102 cases of myeloid sarcoma diagnosed during the period from 1990 to 2006.
  • The tumor cells in all cases were positive for CD68 (KP1), CD68 (PGM1), lysozyme and CD45.
  • They were negative for MPO, CD15, CD163, TdT, CD117, T and B cell markers.
  • [MeSH-major] Antigens, CD. Antigens, Differentiation, Myelomonocytic. Leukemia, Monocytic, Acute / pathology. Sarcoma, Myeloid / pathology
  • [MeSH-minor] Adult. Antigens, CD15 / immunology. Antigens, CD45. Child. Diagnosis, Differential. Female. Humans. Immunohistochemistry / methods. Immunophenotyping. Male. Receptors, Cell Surface / immunology. Sarcoma / immunology. Sarcoma / pathology

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  • (PMID = 18509981.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD15; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD163 antigen; 0 / CD68 antigen, human; 0 / Receptors, Cell Surface; EC 3.1.3.48 / Antigens, CD45
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29. Park JB, Lee JK, Park SJ, Kim KW, Riew KD: Mitochondrial involvement in fas-mediated apoptosis of human lumbar disc cells. J Bone Joint Surg Am; 2005 Jun;87(6):1338-42
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  • The TUNEL (terminal deoxynucleotidyl transferase [TDT]-mediated dUTP nick end labeling) assay was performed to confirm the occurrence of apoptosis of the disc cells.
  • TUNEL-positive disc cells were identified in all samples.
  • [MeSH-minor] Adult. BH3 Interacting Domain Death Agonist Protein. Blotting, Western. Carrier Proteins / physiology. Caspase 3. Caspase 8. Caspase 9. Caspases / metabolism. Cytochromes c / metabolism. Female. Humans. Immunohistochemistry. In Situ Nick-End Labeling. Male. Middle Aged. Mitochondria / physiology

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  • (PMID = 15930545.001).
  • [ISSN] 0021-9355
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / BH3 Interacting Domain Death Agonist Protein; 0 / BID protein, human; 0 / Carrier Proteins; 9007-43-6 / Cytochromes c; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / CASP9 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 8; EC 3.4.22.- / Caspase 9; EC 3.4.22.- / Caspases
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30. Pan Y, Li GD, Liu WP, Zhang WY, Tang Y, Li FY: [Lymphoblastic lymphoma and acute lymphoblastic leukemia: a clinicopathologic, immunophenotypic and prognostic study in 153 Chinese patients]. Zhonghua Bing Li Xue Za Zhi; 2009 Dec;38(12):810-5
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  • [Title] [Lymphoblastic lymphoma and acute lymphoblastic leukemia: a clinicopathologic, immunophenotypic and prognostic study in 153 Chinese patients].
  • OBJECTIVE: To study the clinicopathologic features, immunohistochemical findings and prognosis of precursor lymphoblastic lymphoma/acute lymphoblastic leukemia (LBL/ALL).
  • RESULTS: Staining for TdT and CD99 was positive in 79.1% (121/153 cases) and 96.3% (131/136 cases), respectively.
  • CONCLUSIONS: Both TdT and CD99 are useful markers for the diagnosis of precursor lymphoblastic malignancy.
  • [MeSH-major] Antigens, CD / metabolism. Cell Adhesion Molecules / metabolism. DNA Nucleotidylexotransferase / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Bone Marrow / pathology. Child. Child, Preschool. Female. Humans. Immunophenotyping. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Young Adult


31. Gonzalez SA, Fiel MI, Sauk J, Canchis PW, Liu RC, Chiriboga L, Yee HT, Jacobson IM, Talal AH: Inverse association between hepatic stellate cell apoptosis and fibrosis in chronic hepatitis C virus infection. J Viral Hepat; 2009 Feb;16(2):141-8
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  • We used immunohistochemical techniques to identify activated (alpha-smooth muscle actin+), proliferative (Ki-67+) and apoptotic (terminal deoxynucleotidyl transferase [TdT]-mediated dUTP nick end-labelling+) HSC in liver biopsy specimens from all subjects.
  • The same pathologist enumerated positive cells per high-power field (HPF, x 200) in 20 periportal/lobular areas.
  • HSC apoptosis was decreased in HCV-positive subjects compared with controls (median 0.4, range 0.0-3.1 vs 1.1, 0.2-3.5 cells/HPF, P = 0.02).
  • Among HCV-positive subjects, HSC apoptosis was decreased in those with moderate to advanced fibrosis (P = 0.04) compared with those with mild fibrosis.
  • [MeSH-minor] Adult. Aged. Animals. Cross-Sectional Studies. Female. Humans. Male. Middle Aged. Severity of Illness Index. Statistics as Topic

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  • (PMID = 19175868.001).
  • [ISSN] 1365-2893
  • [Journal-full-title] Journal of viral hepatitis
  • [ISO-abbreviation] J. Viral Hepat.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK 02573
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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32. Kiefer T, Schüler F, Knopp A, Wimmer M, Hirt C, Schaefer HE, Dölken G: A human Burkitt's lymphoma cell line carrying t(8;22) and t(14;18) translocations. Ann Hematol; 2007 Nov;86(11):821-30
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  • Cell culture was started with circulating lymphoma cells from the peripheral blood of an adult male Caucasian patient with Burkitt's lymphoma after the second relapse.
  • Surface marker studies of the cell line showed that the cells were positive for CALLA (CD10), CD19, cyCD22, cyCD79a and HLA-DR and negative for TdT, IgM, CD5 and CD23.

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  • (PMID = 17622530.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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33. Pei SN, Kuo CY, Ma MC, Wang MC: Mediastinal mass and malignant pleural effusion in an aleukemic case with pre-B acute lymphoblastic leukemia. J Pediatr Hematol Oncol; 2009 Feb;31(2):139-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal mass and malignant pleural effusion in an aleukemic case with pre-B acute lymphoblastic leukemia.
  • However, an immunophenotypic study of the effusion revealed the following: TdT+, CD34+, CD19+, CD7(-), CD33(-), CD10(-), sIgM(-), and positive cytoplasmic mu heavy-chain immunoglobulins.
  • After a bone marrow examination, we diagnosed the patient with pre-B acute lymphoblastic leukemia (ALL).
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Pleural Effusion, Malignant / diagnosis. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Marrow Examination. Disease-Free Survival. Humans. Immunophenotyping. Male. Young Adult

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  • (PMID = 19194202.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Bulut S, Ozdemir BH, Alaaddinoĝlu EE, Oduncuoĝlu FB, Bulut OE, Demirhan B: Effect of cyclosporin A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients. J Periodontol; 2005 May;76(5):691-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The 15 systemically and periodontally healthy volunteer control group were immunohistochemically analyzed for grades of p53 and bcl-2 expression, and were processed using terminal TdT-mediated dUTP-biotin nick-end labeling (TUNEL) technique to identify and grade levels of apoptosis.
  • There was a significant positive correlation between serum CsA level and level of bcl-2 expression, but serum CsA was not significantly correlated with level of apoptosis or level of p53 expression.
  • [MeSH-minor] Adult. Analysis of Variance. Case-Control Studies. Chi-Square Distribution. Female. Gingiva / drug effects. Gingiva / metabolism. Humans. In Situ Nick-End Labeling. Kidney Transplantation. Male. Middle Aged

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  • (PMID = 15898928.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 83HN0GTJ6D / Cyclosporine
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35. Jin M, Liu B, Wang L, Xu JY: [Clinicopathologic study of metaplastic thymoma]. Zhonghua Bing Li Xue Za Zhi; 2006 May;35(5):285-8
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  • In contrast, the spindle cells were diffusely positive for vimentin and epithelial membrane antigen.
  • The background lymphocytes were positive for CD3, but not for TdT and CD99.
  • [MeSH-minor] Adult. Antigens, CD5 / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunohistochemistry. Mediastinum / pathology. Microscopy, Electron. Middle Aged. Vimentin / metabolism

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  • (PMID = 16777000.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD5; 0 / Vimentin; 68238-35-7 / Keratins
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