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1. Cerveira N, Meyer C, Santos J, Torres L, Lisboa S, Pinheiro M, Bizarro S, Correia C, Norton L, Marschalek R, Teixeira MR: A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. BMC Cancer; 2010;10:518
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia.
  • In this work we present the identification of a novel MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia.
  • METHODS: Cytogenetics, fluorescence in situ hybridization (FISH), molecular studies (RT-PCR and LDI-PCR), and bioinformatic sequence analysis were used to characterize the CT45A2 gene as novel MLL fusion partner in pediatric acute leukemia.
  • Finally, we demonstrate that all breakpoint regions are rich in long repetitive motifs, namely LINE/L1 and SINE/Alu sequences, but all breakpoints were exclusively identified outside these repetitive DNA sequences.
  • CONCLUSION: We have identified CT45A2 as a novel spliced MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia, as a result of a cryptic insertion of 11q23 in Xq26.3.
  • Since CT45A2 is the first Cancer/Testis antigen family gene found fused with MLL in acute leukemia, future studies addressing its biologic relevance for leukemogenesis are warranted.
  • [MeSH-major] Antigens, Neoplasm / genetics. Leukemia, Myeloid, Acute / genetics. Myeloid-Lymphoid Leukemia Protein / genetics. Oncogene Proteins, Fusion / genetics

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  • (PMID = 20920256.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CT45A1 protein, human; 0 / Oncogene Proteins, Fusion; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein
  • [Other-IDs] NLM/ PMC2956734
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2. Wueest S, Rapold RA, Schoenle EJ, Konrad D: Fas activation in adipocytes impairs insulin-stimulated glucose uptake by reducing Akt. FEBS Lett; 2010 Oct 8;584(19):4187-92
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  • In 3T3-L1 adipocytes, activation of Fas by Fas ligand decreased insulin-stimulated glucose uptake, without affecting cell viability.
  • [MeSH-minor] 3T3-L1 Cells. Animals. Biological Transport, Active / drug effects. Fas Ligand Protein / metabolism. Fas Ligand Protein / pharmacology. Mice. Mice, Inbred C57BL. Mice, Knockout. Signal Transduction / drug effects

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  • [Copyright] Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20828573.001).
  • [ISSN] 1873-3468
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Fas Ligand Protein; 0 / Fas protein, mouse; 0 / Fasl protein, mouse; 0 / Insulin; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; IY9XDZ35W2 / Glucose
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3. Tanyeli A, Erbey F, Bayram I, Kömür M: Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis. Asian Pac J Cancer Prev; 2010;11(6):1823-6
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  • [Title] Myeloid antigen positivity in Turkish children with acute lymphoblastic leukemia lacks influence on prognosis.
  • INTRODUCTION: Several studies have suggested that the presence of myeloid antigens is a poor prognostic factor in patients with acute lymphoid leukemia (ALL).
  • MATERIALS AND METHODS: Seventy-three children with a diagnosis of ALL-L1 and 38 with ALL-L2 were included.
  • RESULTS: Myeloid antigens were positive in 48.4% with ALL-L1 and 60.5% with ALL-L2, the difference not being significant.
  • [MeSH-major] Antigens, Differentiation, Myelomonocytic / metabolism. Antigens, Surface / metabolism. Biomarkers, Tumor / metabolism. Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism

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  • (PMID = 21338240.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Antigens, Surface; 0 / Biomarkers, Tumor
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4. MacDonald KD, McKenzie KR, Henderson MJ, Hawkins CE, Vij N, Zeitlin PL: Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice. Am J Physiol Lung Cell Mol Physiol; 2008 Nov;295(5):L933-40
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  • [Title] Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice.
  • Periciliary fluid balance is maintained by the coordination of sodium and chloride channels in the apical membranes of the airways.
  • In the absence of the cystic fibrosis transmembrane regulator (CFTR), chloride secretion is diminished and sodium reabsorption exaggerated.
  • ClC-2, a pH- and voltage-dependent chloride channel, is present on the apical membranes of airway epithelial cells.
  • We hypothesized that ClC-2 agonists would provide a parallel pathway for chloride secretion.
  • Using nasal potential difference (NPD) measurements, we quantified lubiprostone-mediated Cl(-) transport in sedated cystic fibrosis null (gut-corrected), C57Bl/6, and A/J mice during nasal perfusion of lubiprostone (a putative ClC-2 agonist).
  • Baseline, amiloride-inhibited, chloride-free gluconate-substituted Ringer with amiloride and low-chloride Ringer plus lubiprostone (at increasing concentrations of lubiprostone) were perfused, and the NPD was continuously recorded.
  • A clear dose-response relationship was detected in all murine strains.
  • The magnitude of the NPD response to 20 muM lubiprostone was -5.8 +/- 2.1 mV (CF, n = 12), -8.1 +/- 2.6 mV (C57Bl/6 wild-type, n = 12), and -5.3 +/- 1.2 mV (AJ wild-type, n = 8).
  • A cohort of ClC-2 knockout mice did not respond to 20 muM lubiprostone (n = 6, P = 0.27).
  • In C57Bl/6 mice, inhibition of CFTR with topical application of CFTR inhibitor-172 did not abolish the lubiprostone response, thus confirming the response seen is independent of CFTR regulation.
  • RT-PCR confirmed expression of ClC-2 mRNA in murine lung homogenate.
  • The direct application of lubiprostone in the CF murine nasal airway restores nearly normal levels of chloride secretion in nasal epithelia.

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  • (PMID = 18805957.001).
  • [ISSN] 1040-0605
  • [Journal-full-title] American journal of physiology. Lung cellular and molecular physiology
  • [ISO-abbreviation] Am. J. Physiol. Lung Cell Mol. Physiol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL 59410; United States / NHLBI NIH HHS / HL / T32 HL 72748
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chloride Channels; 0 / Chlorides; 0 / ClC-2 chloride channels; 0 / RNA, Messenger; 126880-72-6 / Cystic Fibrosis Transmembrane Conductance Regulator; 7662KG2R6K / Lubiprostone; 8L70Q75FXE / Adenosine Triphosphate; F5TD010360 / Alprostadil
  • [Other-IDs] NLM/ PMC2584880
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5. Balamurugan S, Sugapriya D, Shanthi P, Thilaka V, Venkatadesilalu S, Pushpa V, Madhavan M: Multidrug resistance 1 gene expression and AgNOR in childhood acute leukemias. Indian J Hematol Blood Transfus; 2007 Dec;23(3-4):73-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multidrug resistance 1 gene expression and AgNOR in childhood acute leukemias.
  • We have studied MDR1 expression and AgNORS in 41 cases of acute leukemia in children.
  • In this study, AgNOR counts in patients with acute lymphoblastic leukemia (ALL) L2 subtype (FAB classification) were significantly higher as compared to the ALL L1 subtype.
  • Similarly, mean AgNOR count in the acute myeloid Leukemia (AML) M2 subtype was significantly higher as compared to the ALL L1 subtype.
  • However, there was no correlation between AgNOR and treatment outcome or between AgNOR counts and MDR1 expression in any of the subtypes of acute leukemia included in this series.
  • This would suggest that factors other than MDR1 may be of relevance in Pediatric ALL.

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  • (PMID = 23100919.001).
  • [ISSN] 0971-4502
  • [Journal-full-title] Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
  • [ISO-abbreviation] Indian J Hematol Blood Transfus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3453125
  • [Keywords] NOTNLM ; Acute leukemia / AgNOR / Multidrug Resistance 1 / P-glycoprotein
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6. Wachowiak R, Fiegel HC, Kaifi JT, Quaas A, Krickhahn A, Schurr PG, Erttmann R, Schachner M, Kluth D, Sauter G, Izbicki JR: L1 is associated with favorable outcome in neuroblastomas in contrast to adult tumors. Ann Surg Oncol; 2007 Dec;14(12):3575-80
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  • [Title] L1 is associated with favorable outcome in neuroblastomas in contrast to adult tumors.
  • BACKGROUND: Neuroblastoma is the most common solid tumor in childhood with unconventional clinical behavior.
  • L1, a neuronal cell adhesion molecule, is associated with poor survival in malignant adult tumors.
  • The aim of the current study was to determine expression of L1 in pediatric neuroblastoma.
  • METHODS: L1 expression was assessed on a tissue microarray with 66 surgically resected neuroblastoma samples by immunohistochemistry with a monoclonal antibody and peroxidase method.
  • Additionally, mRNA expression was analyzed by reverse transcriptase-polymerase chain reaction with L1-specific primers.
  • RESULTS: L1 was detected in 57 (86%) of 66 neuroblastomas, whereas 9 (14%) were L1 negative.
  • Analysis with Kaplan-Meier method revealed a surprising and contrary finding to adult tumor entities: an association of L1 positivity with better event-free and overall survival (P < .001 and P < .01 by log rank test).
  • Multivariate Cox regression analysis showed an independent prognostic impact of L1 negativity for event-free and overall survival of the children (P < .05).
  • CONCLUSIONS: In contrast to adult tumor entities, where L1 is associated with aggressive clinical behavior, our data show that L1 predicts good outcome in children with neuroblastoma.
  • This novel finding suggests an inverse role of L1 in neuroblastoma.
  • Future studies might focus on the molecular basis of the varying effect of L1 in different tumors.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Gene Expression Regulation, Neoplastic. Neural Cell Adhesion Molecule L1 / metabolism. Neuroblastoma / metabolism

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  • (PMID = 17917782.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neural Cell Adhesion Molecule L1; 0 / RNA, Messenger
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7. Ojima S, Nakata H, Kakigi R: An ERP study of second language learning after childhood: effects of proficiency. J Cogn Neurosci; 2005 Aug;17(8):1212-28

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An ERP study of second language learning after childhood: effects of proficiency.
  • One approach to address this issue is to compare the processes of second language (L2) learning after childhood and those of first language (L1) learning during childhood.
  • To study the cortical process of postchildhood L2 learning, we compared event-related brain potentials recorded from two groups of adult Japanese speakers who attained either high or intermediate proficiency in English after childhood (J-High and J-Low), and adult native English speakers (ENG).
  • Because early maturation and stability of semantic processing as opposed to syntactic processing are also a feature of L1 processing, postchildhood L2 learning may be governed by the same brain properties as those which govern childhood L1 learning.

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  • (PMID = 16197679.001).
  • [ISSN] 0898-929X
  • [Journal-full-title] Journal of cognitive neuroscience
  • [ISO-abbreviation] J Cogn Neurosci
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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8. Wachowiak R, Rawnaq T, Metzger R, Quaas A, Fiegel H, Kähler N, Rolle U, Izbicki JR, Kaifi J, Till H: Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma? Pediatr Surg Int; 2008 Dec;24(12):1361-4
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  • [Title] Universal expression of cell adhesion molecule NCAM in neuroblastoma in contrast to L1: implications for different roles in tumor biology of neuroblastoma?
  • NCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily with structural similarities to cell adhesion molecule L1.
  • The aim of this study was to determine the expression of NCAM in neuroblastoma and to compare the results to the findings of a previous study which examined L1 expression in the same group of patients.
  • RESULTS: Strong expression of NCAM was detected in all of the 66 (100%) neuroblastoma tumors in contrast to L1 which was not expressed in all tumors.
  • CONCLUSION: In contrast to L1, which was found to predict favorable outcome, NCAM is universally expressed in neuroblastoma.
  • Therefore NCAM represents a marker for neuroblastomas irrespectively of their stages whereas L1 as an indicator for developing neuronal cells seems to identify more mature stages of this tumor.
  • [MeSH-major] Antigens, Neoplasm / metabolism. Biomarkers, Tumor / biosynthesis. Neural Cell Adhesion Molecule L1 / biosynthesis. Neural Cell Adhesion Molecules / biosynthesis. Neuroblastoma / metabolism

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  • (PMID = 18972120.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Neural Cell Adhesion Molecule L1; 0 / Neural Cell Adhesion Molecules
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9. Block SL, Nolan T, Sattler C, Barr E, Giacoletti KE, Marchant CD, Castellsagué X, Rusche SA, Lukac S, Bryan JT, Cavanaugh PF Jr, Reisinger KS, Protocol 016 Study Group: Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in male and female adolescents and young adult women. Pediatrics; 2006 Nov;118(5):2135-45
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of the immunogenicity and reactogenicity of a prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in male and female adolescents and young adult women.
  • OBJECTIVE: Prophylactic vaccination of 16- to 23-year-old females with a quadrivalent human papillomavirus (types 6, 11, 16, 18) L1 virus-like particle vaccine has been shown to prevent type-specific human papillomavirus infection and associated clinical disease.

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  • (PMID = 17079588.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; 0 / Papillomavirus Vaccines; 0 / Viral Vaccines
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10. Acott PD, Wong JA, Lang BA, Crocker JF: Pamidronate treatment of pediatric fracture patients on chronic steroid therapy. Pediatr Nephrol; 2005 Mar;20(3):368-73
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  • [Title] Pamidronate treatment of pediatric fracture patients on chronic steroid therapy.
  • Pediatric nephrology and rheumatology patients with steroid-induced osteopenia are at risk of skeletal fracture.
  • Bone mineral density of L1-L4 (BMD) was assessed prior to treatment and at six-month intervals, and compared to 17 disease-age-gender-steroid dose-matched control patients.
  • Despite ongoing steroid treatment, pamidronate significantly increased L1-L4 BMD Z-scores (mean+/-SE) relative to baseline (pamidronate vs control: 0-6 months: 0.27+/-0.14 vs -0.82+/-0.31; 0-12 months: 0.63+/-0.17 vs -0.46+/-0.27; 0-18 months: 0.55+/-0.32 vs 0.17+/-0.27; 0-24 months: 0.15+/-0.21 vs -0.23+/-0.22; 0-30 or 36 months: 0.77+/-0.71 vs -0.68+/-0.25) with repeated measures ANOVA assessment (F=11.27, p=0.0057).
  • This study supports the safety and efficacy of pamidronate in steroid-induced fractures in pediatric nephrology and rheumatology patients.

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  • (PMID = 15690187.001).
  • [ISSN] 0931-041X
  • [Journal-full-title] Pediatric nephrology (Berlin, Germany)
  • [ISO-abbreviation] Pediatr. Nephrol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Diphosphonates; 0 / Steroids; OYY3447OMC / pamidronate
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11. Block SL, Brown DR, Chatterjee A, Gold MA, Sings HL, Meibohm A, Dana A, Haupt RM, Barr E, Tamms GM, Zhou H, Reisinger KS: Clinical trial and post-licensure safety profile of a prophylactic human papillomavirus (types 6, 11, 16, and 18) l1 virus-like particle vaccine. Pediatr Infect Dis J; 2010 Feb;29(2):95-101
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  • [Title] Clinical trial and post-licensure safety profile of a prophylactic human papillomavirus (types 6, 11, 16, and 18) l1 virus-like particle vaccine.

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  • (PMID = 19952863.001).
  • [ISSN] 1532-0987
  • [Journal-full-title] The Pediatric infectious disease journal
  • [ISO-abbreviation] Pediatr. Infect. Dis. J.
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Clinical Trial, Phase III; Clinical Trial, Phase IV; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; 0 / Papillomavirus Vaccines; 0 / Placebos; 0 / Vaccines, Virosome
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12. Raybaud C, Di Rocco C: Brain malformation in syndromic craniosynostoses, a primary disorder of white matter: a review. Childs Nerv Syst; 2007 Dec;23(12):1379-88
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  • L1 cell adhesion molecule (L1CAM) gene plays a major role in the development of the white matter and its mutation in humans (callosal agenesis, retardation, adducted thumbs, spasticity, and hydrocephalus syndrome, Bickers-Adams syndrome) or in mice causes similar defects of the corpus callosum, septum pellucidum, centrum semi-ovale, and cortico-spinal tracts.
  • [MeSH-minor] Humans. Mutation. Neural Cell Adhesion Molecule L1 / genetics. Neural Cell Adhesion Molecule L1 / metabolism. Receptors, Fibroblast Growth Factor / genetics. Receptors, Fibroblast Growth Factor / metabolism. Syndrome

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  • (PMID = 17882438.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecule L1; 0 / Receptors, Fibroblast Growth Factor
  • [Number-of-references] 39
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13. Kinoshita Y, Tajiri T, Souzaki R, Tatsuta K, Higashi M, Izaki T, Takahashi Y, Taguchi T: Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. J Pediatr Hematol Oncol; 2008 Jun;30(6):447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND PURPOSE: The serum alpha-fetoprotein (AFP) level has been used as a tumor marker for hepatoblastoma, and malignant germ cell tumors in pediatric patients.
  • The AFP has 3 isoforms (L1, L2, L3), and the usefulness of the L3 fraction as a diagnostic marker for the adult hepatocellular carcinoma is well known.
  • However, there are few reports dealing with various pediatric malignant tumors.
  • In the current study, we analyzed the diagnostic value of AFP fractions for pediatric diseases, in particular, those occurring in the neoinfantile period.

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  • (PMID = 18525461.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Lectins; 0 / Protein Isoforms; 0 / alpha-Fetoproteins
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14. Kapel N, Campeotto F, Kalach N, Baldassare M, Butel MJ, Dupont C: Faecal calprotectin in term and preterm neonates. J Pediatr Gastroenterol Nutr; 2010 Nov;51(5):542-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Feces / chemistry. Infant, Newborn. Infant, Premature. Intestinal Diseases / diagnosis. Leukocyte L1 Antigen Complex / analysis. Neonatal Screening / methods

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  • (PMID = 20818270.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Leukocyte L1 Antigen Complex
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15. Pratelli L, Verri E, Fortini M, Marconi S, Zolezzi C, Fornasari PM, Gamberini MR, De Sanctis V: Chelation therapy and bone metabolism markers in thalassemia major. J Pediatr Endocrinol Metab; 2006 Nov;19(11):1335-42
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  • The aim of our study was to investigate the effects of subcutaneous desferrioxamine (DFX) and oral deferiprone (L1) therapy on bone metabolism markers in patients with thalassemia major.
  • In particular, TGFbeta1 was higher in patients with thalassemia receiving L1 treatment.

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  • (PMID = 17220062.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Intercellular Signaling Peptides and Proteins; 0 / Iron Chelating Agents; 0 / Parathyroid Hormone; 0 / Pyridones; 0 / Siderophores; 104982-03-8 / Osteocalcin; 1406-16-2 / Vitamin D; 2BTY8KH53L / deferiprone; 64719-49-9 / 25-hydroxyvitamin D; 66772-14-3 / 1,25-dihydroxyvitamin D; EC 3.1.3.1 / Alkaline Phosphatase; J06Y7MXW4D / Deferoxamine
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16. Biswas A, Puri T, Goyal S, Kumar S, Sharma A, Paliwal P, Suri V, Jain A, Julka PK, Rath GK: Spinal myxopapillary ependymoma with Down syndrome: exploring an unusual association. J Pediatr Hematol Oncol; 2010 Jan;32(1):e38-41
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  • SUMMARY: In patients with Down syndrome, cancers like leukemia and testicular tumors are frequent, but association with central nervous system tumors is rare.
  • Magnetic resonance imaging of dorsolumbar spine revealed an intramedullary mass (L1 to L5 level).


17. Glard Y, Launay F, Viehweger E, Hamel A, Jouve JL, Bollini G: Neurological classification in myelomeningocele as a spine deformity predictor. J Pediatr Orthop B; 2007 Jul;16(4):287-92
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  • Groups were defined as follows: group I, L5 or below (meaning that all the patients in this group have a paralysis that at least leaves the L5 segment intact); group II, L3-L4; group III, L1-L2; group IV, T12 and above (meaning that all the patients in this group have a paralysis that reaches T11 or above).

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  • (PMID = 17527108.001).
  • [ISSN] 1060-152X
  • [Journal-full-title] Journal of pediatric orthopedics. Part B
  • [ISO-abbreviation] J Pediatr Orthop B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Boylu U, Horasanli K, Tanriverdi O, Kendirci M, Gumus E, Miroglu C: Evaluation of bone mineral density after ileocystoplasty in children with and without myelomeningocele. Pediatr Surg Int; 2006 Apr;22(4):375-9
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  • BMD was measured at L1-L4 and femoral neck, and compared to age- and sex-matched population.
  • Mean BMD at L1-L4 was 55.7% in neurogenic group and 83.8% in non-neurogenic group.

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  • (PMID = 16518593.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Electrolytes; AYI8EX34EU / Creatinine
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19. Diamanti A, Colistro F, Basso MS, Papadatou B, Francalanci P, Bracci F, Muraca M, Knafelz D, De Angelis P, Castro M: Clinical role of calprotectin assay in determining histological relapses in children affected by inflammatory bowel diseases. Inflamm Bowel Dis; 2008 Sep;14(9):1229-35
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  • BACKGROUND: Inflammatory bowel diseases (IBD) are characterized by periods of remission with recurrent episodes of symptom exacerbation because of acute intestinal inflammation, which is correctly evaluated by endoscopy with biopsy sampling.
  • The aim of our study was to retrospectively assess the clinical efficacy of the calprotectin assay in determining histological relapses of pediatric IBD patients.
  • CONCLUSIONS: FC seems to be a direct measure of intestinal inflammation and therefore a good marker of the risk of histological relapse in pediatric IBD patients.
  • [MeSH-major] Feces / chemistry. Inflammatory Bowel Diseases / metabolism. Leukocyte L1 Antigen Complex / metabolism

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  • (PMID = 18398894.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leukocyte L1 Antigen Complex
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20. Ertekin V, Selimoğlu MA, Turgut A, Bakan N: Fecal calprotectin concentration in celiac disease. J Clin Gastroenterol; 2010 Sep;44(8):544-6
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  • CONCLUSIONS: It was found that FC concentration is increased in childhood CD, related to the severity of histopathologic findings and responsive to GFD.
  • [MeSH-major] Celiac Disease / physiopathology. Diet, Gluten-Free. Feces / chemistry. Leukocyte L1 Antigen Complex / metabolism

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  • (PMID = 20054281.001).
  • [ISSN] 1539-2031
  • [Journal-full-title] Journal of clinical gastroenterology
  • [ISO-abbreviation] J. Clin. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leukocyte L1 Antigen Complex
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21. Rao RP, Danduran MJ, Dixon JE, Frommelt PC, Berger S, Zangwill SD: Near infrared spectroscopy: guided tilt table testing for syncope. Pediatr Cardiol; 2010 Jul;31(5):674-9
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  • Two probes for NIRS monitoring were placed on the forehead and above the left paravertebral level at the T10 to L1 space.

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  • (PMID = 20204346.001).
  • [ISSN] 1432-1971
  • [Journal-full-title] Pediatric cardiology
  • [ISO-abbreviation] Pediatr Cardiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. Choma T, Burke M, Kim C, Kakarlapudi R: Epidural abscess as a delayed complication of spinal instrumentation in scoliosis surgery: a case of progressive neurologic dysfunction with complete recovery. Spine (Phila Pa 1976); 2008 Feb 1;33(3):E76-80
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  • It is exceedingly uncommon in the pediatric population.
  • Deep wound infection after adolescent idiopathic scoliosis surgery is a well-known entity that has been reported in several studies; however, we could find no documented incidences of epidural abscess resulting from adolescent idiopathic scoliosis surgery in the pediatric population.
  • Her postoperative course was complicated by acute wound infection that underwent irrigation and debridement with retention of implants.
  • RESULTS: After magnetic resonance imaging confirmation of a T5 to T10 epidural mass, the patient underwent debridement through her fusion mass from T5 to L1.

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  • (PMID = 18303449.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 5GMR90S4KN / Methylprednisolone Hemisuccinate
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23. Canani RB, de Horatio LT, Terrin G, Romano MT, Miele E, Staiano A, Rapacciuolo L, Polito G, Bisesti V, Manguso F, Vallone G, Sodano A, Troncone R: Combined use of noninvasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease. J Pediatr Gastroenterol Nutr; 2006 Jan;42(1):9-15
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  • [MeSH-major] Antibodies, Antineutrophil Cytoplasmic / analysis. Antibodies, Fungal / analysis. Diagnostic Tests, Routine / standards. Inflammatory Bowel Diseases / diagnosis. Leukocyte L1 Antigen Complex / analysis

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  • (PMID = 16385247.001).
  • [ISSN] 0277-2116
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Antibodies, Fungal; 0 / Leukocyte L1 Antigen Complex
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24. Vassilyadi M, Michaud J: Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread. Pediatr Neurosurg; 2005 Jan-Feb;41(1):29-34
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  • Spine MRI showed diffuse leptomeningeal enhancement and a 1.5-cm intramedullary lesion at T12-L1 associated with minimal edema.

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15886510.001).
  • [ISSN] 1016-2291
  • [Journal-full-title] Pediatric neurosurgery
  • [ISO-abbreviation] Pediatr Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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25. Quail MA, Russell RK, Van Limbergen JE, Rogers P, Drummond HE, Wilson DC, Gillett PM: Fecal calprotectin complements routine laboratory investigations in diagnosing childhood inflammatory bowel disease. Inflamm Bowel Dis; 2009 May;15(5):756-9
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  • [Title] Fecal calprotectin complements routine laboratory investigations in diagnosing childhood inflammatory bowel disease.
  • Fecal calprotectin measurement is a significant advance when used contemporaneously and in addition to a routine panel of blood tests in the diagnosis of pediatric IBD.
  • [MeSH-major] Biomarkers / analysis. Colitis, Ulcerative / diagnosis. Crohn Disease / diagnosis. Feces / chemistry. Leukocyte L1 Antigen Complex / analysis

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  • (PMID = 19107785.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leukocyte L1 Antigen Complex
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26. Chou IJ, Lin KL, Wang HS, Wang CJ: Evaluation of bone mineral density in children receiving carbamazepine or valproate monotherapy. Acta Paediatr Taiwan; 2007 Nov-Dec;48(6):317-22
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  • BACKGROUND: Antiepileptic drugs have been shown to be associated with a lowering of bone mineral density in childhood and adolescence, which are critical periods of skeletal mineralization.
  • Lumbar bone mineral density of L1 to L4 was measured by dual-energy X-ray absorptiometry.

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  • (PMID = 18437965.001).
  • [ISSN] 1608-8115
  • [Journal-full-title] Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi
  • [ISO-abbreviation] Acta Paediatr Taiwan
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Anticonvulsants; 33CM23913M / Carbamazepine; 614OI1Z5WI / Valproic Acid
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27. Mann G, Attarbaschi A, Steiner M, Simonitsch I, Strobl H, Urban C, Meister B, Haas O, Dworzak M, Gadner H, Austrian Berlin-Frankfurt-Münster (BFM) Group: Early and reliable diagnosis of non-Hodgkin lymphoma in childhood and adolescence: contribution of cytomorphology and flow cytometric immunophenotyping. Pediatr Hematol Oncol; 2006 Apr-May;23(3):167-76
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  • [Title] Early and reliable diagnosis of non-Hodgkin lymphoma in childhood and adolescence: contribution of cytomorphology and flow cytometric immunophenotyping.
  • Non-Hodgkin lymphoma (NHL) represents one of the most rapidly growing malignancies in childhood and adolescence.
  • The authors identified 23 patients with Burkitt lymphoma by the combination of FAB L3 morphology and a mature B-cell phenotype and 22 patients with lymphoblastic lymphoma by FAB L1/L2 morphology and a T-/B-cell precursor phenotype.
  • Burkitt lymphoma, lymphoblastic lymphoma, and, in a few cases, some large cell lymphomas could be classified reliably by cytomorphology and immunophenotyping of freshly obtained tumor cell material, enabling an early start of specific lymphoma treatment.
  • [MeSH-minor] Abdominal Neoplasms / classification. Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / pathology. Adolescent. Antigens, CD / analysis. Austria / epidemiology. Biopsy, Fine-Needle. Burkitt Lymphoma / diagnosis. Burkitt Lymphoma / pathology. Cell Nucleus / ultrastructure. Cell Size. Child. Child, Preschool. Cytoplasm / ultrastructure. Early Diagnosis. Feasibility Studies. Female. Humans. In Situ Hybridization, Fluorescence. Infant. Lymphocyte Subsets / pathology. Lymphoma, Large B-Cell, Diffuse / diagnosis. Lymphoma, Large B-Cell, Diffuse / pathology. Male. Mediastinal Neoplasms / classification. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / pathology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Prospective Studies. Staining and Labeling


28. Turner D, Leach ST, Mack D, Uusoue K, McLernon R, Hyams J, Leleiko N, Walters TD, Crandall W, Markowitz J, Otley AR, Griffiths AM, Day AS: Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: a prospective multicentre comparison of predicting outcomes and monitoring response. Gut; 2010 Sep;59(9):1207-12
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  • Stool samples from 101 children (13.3 + or - 3.6 years; Pediatric UC Activity Index (PUCAI) at admission 72 + or - 12 points) were obtained at the third day of intravenous steroid therapy.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Drug Monitoring / methods. Epidemiologic Methods. Glucocorticoids / therapeutic use. Humans. Lactoferrin / metabolism. Leukocyte L1 Antigen Complex / metabolism. Prognosis. Pyruvate Kinase / metabolism. S100 Proteins / metabolism. S100A12 Protein. Treatment Outcome

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  • (PMID = 20801771.001).
  • [ISSN] 1468-3288
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Glucocorticoids; 0 / Leukocyte L1 Antigen Complex; 0 / S100 Proteins; 0 / S100A12 Protein; 0 / S100A12 protein, human; EC 2.7.1.40 / Pyruvate Kinase; EC 3.4.21.- / Lactoferrin
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29. Poyrazoglu S, Gunoz H, Darendeliler F, Bas F, Tutunculer F, Eryilmaz SK, Bundak R, Saka N: Successful results of pamidronate treatment in children with osteogenesis imperfecta with emphasis on the interpretation of bone mineral density for local standards. J Pediatr Orthop; 2008 Jun;28(4):483-7
MedlinePlus Health Information. consumer health - Osteogenesis Imperfecta.

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  • Serum calcium, phosphorus, bone turnover markers, L1-L4 areal BMD (aBMD), and fracture rate were evaluated.
  • L1 to L4 aBMD and Z score increased markedly, and fracture rate decreased in all patients during therapy.
  • Mean L1 to L4 aBMD Z scores according to Turkish reference data were higher than that of manufacturer values (P = 0.004).
  • Correction of L1 to L4 vertebrae for bone size yielded to a decrease in osteoporosis in OI patients (41.5% vs 22.3%).

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  • (PMID = 18520289.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Bone Density Conservation Agents; 0 / Diphosphonates; OYY3447OMC / pamidronate
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30. Rojas-Gil AP, Ziros PG, Kanetsis E, Papathanassopoulou V, Nikolakopoulou NM, He K, Frank SJ, Papavassiliou AG, Spiliotis BE: Combined effect of mutations of the GH1 gene and its proximal promoter region in a child with growth hormone neurosecretory dysfunction (GHND). J Mol Med (Berl); 2007 Sep;85(9):1005-13

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  • [MeSH-minor] 3T3-L1 Cells. Adolescent. Animals. Base Sequence. Cell Line, Tumor. DNA Mutational Analysis. Electrophoretic Mobility Shift Assay. Female. HeLa Cells. Humans. Male. Mice. Molecular Sequence Data. Oligonucleotides / genetics. Oligonucleotides / metabolism. Pedigree. RNA Splicing / genetics. Rats. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17479231.001).
  • [ISSN] 0946-2716
  • [Journal-full-title] Journal of molecular medicine (Berlin, Germany)
  • [ISO-abbreviation] J. Mol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Oligonucleotides; 12629-01-5 / Human Growth Hormone
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31. Diab M, Smith AR, Kuklo TR, Spinal Deformity Study Group: Neural complications in the surgical treatment of adolescent idiopathic scoliosis. Spine (Phila Pa 1976); 2007 Nov 15;32(24):2759-63
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  • METHODS: A review of 1301 consecutive surgical cases was conducted using the Prospective Pediatric Scoliosis Study database, which is maintained by the Spinal Deformity Study Group.
  • The other was an L4 neurapraxia despite lowest instrumented vertebra L1, and resolved spontaneously by 3 months' follow-up.


32. Miyahara K, Kato Y, Seki T, Arakawa A, Lane GJ, Yamataka A: Neuronal immaturity in normoganglionic colon from cases of Hirschsprung disease, anorectal malformation, and idiopathic constipation. J Pediatr Surg; 2009 Dec;44(12):2364-8
MedlinePlus Health Information. consumer health - Constipation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Anal Canal / abnormalities. Anal Canal / metabolism. Colon / innervation. Constipation / pathology. Hirschsprung Disease / pathology. Neural Cell Adhesion Molecule L1 / metabolism. Neurogenesis / physiology. Neurons / metabolism. Neurons / pathology. Rectum / abnormalities. Sialic Acids / metabolism

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  • (PMID = 20006028.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neural Cell Adhesion Molecule L1; 0 / Sialic Acids; 0 / polysialyl neural cell adhesion molecule
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33. Horigome F, Seki T, Kobayashi H, Ozaki T, Yamataka A: Developmental anomalies of the enteric nervous system in normoganglionic segments of bowel from rats with total colonic aganglionosis. Pediatr Surg Int; 2007 Oct;23(10):991-5
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  • [MeSH-major] Enteric Nervous System / abnormalities. Ileum / innervation. Neural Cell Adhesion Molecule L1 / metabolism. Sialic Acids / metabolism

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  • (PMID = 17684751.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Nerve Growth Factors; 0 / Neural Cell Adhesion Molecule L1; 0 / S100 Calcium Binding Protein beta Subunit; 0 / S100 Proteins; 0 / Sialic Acids; 0 / polysialyl neural cell adhesion molecule
  •  go-up   go-down


34. Bauer DF, Shoja MM, Loukas M, Oakes WJ, Tubbs RS: Study of the effects of flexion on the position of the conus medullaris. Childs Nerv Syst; 2008 Sep;24(9):1043-5
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  • BACKGROUND: Previous anatomic studies have shown the conus medullaris to terminate between T12 and L1 vertebral levels in adults with normal spinal anatomy.
  • RESULTS: In all specimens, the conus terminated between T12 and L1 in the prone position.

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  • (PMID = 18431553.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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35. Gan YC, Sgouros S, Walsh AR, Hockley AD: Diastematomyelia in children: treatment outcome and natural history of associated syringomyelia. Childs Nerv Syst; 2007 May;23(5):515-9
MedlinePlus Health Information. consumer health - Syringomyelia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Syringomyelia was present in eight (47%), associated with bony spur between L1 and 4 (p=0.088), spina bifida occulta in ten (58.8%), and spinal lipoma in one (6%).

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  • (PMID = 17028880.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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36. Kumandas S, Koklu E, Gümüs H, Koklu S, Kurtoglu S, Karakukcu M, Keskin M: Effect of carbamezapine and valproic acid on bone mineral density, IGF-I and IGFBP-3. J Pediatr Endocrinol Metab; 2006 Apr;19(4):529-34
Hazardous Substances Data Bank. VALPROIC ACID .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: BMD values at lumbar spine in both the carbamazepine (-1.69 +/- 0.85 mean L1-4 BMD z-scores, mean 35.5 +/- 12.8 months treatment, and 19,478.6 +/- 6,301.3 mg/kg cumulative dose) and valproic acid (-1.28 +/- 0.80 mean L1-4 BMD z-scores, mean 33.7 +/- 15.0 months treatment, and 22,852.4 +/- 12,477.4 mg/kg cumulative dose) groups were significantly lower than that of the control group (-0.23 +/- 0.87 mean L1-4 BMD z-score).

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  • (PMID = 16759039.001).
  • [ISSN] 0334-018X
  • [Journal-full-title] Journal of pediatric endocrinology & metabolism : JPEM
  • [ISO-abbreviation] J. Pediatr. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Insulin-Like Growth Factor Binding Protein 3; 0 / Parathyroid Hormone; 1406-16-2 / Vitamin D; 33CM23913M / Carbamazepine; 614OI1Z5WI / Valproic Acid; 67763-96-6 / Insulin-Like Growth Factor I; EC 3.1.3.1 / Alkaline Phosphatase
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37. Price CT, Knapp DR, Lopez D, Herrera-Soto JA: Infantile kyphosis secondary to lumbar hypoplasia: six cases with excessive upright sleeping as a possible cause. Orthopedics; 2010 Oct;33(10):731
MedlinePlus Health Information. consumer health - Guide to Good Posture.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Some had pseudosubluxation at the T12-L1 level.

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  • [Copyright] Copyright 2010, SLACK Incorporated.
  • (PMID = 20954655.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Wueest S, Rapold RA, Schumann DM, Rytka JM, Schildknecht A, Nov O, Chervonsky AV, Rudich A, Schoenle EJ, Donath MY, Konrad D: Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest; 2010 Jan;120(1):191-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] 3T3-L1 Cells. Animals. Dietary Fats / administration & dosage. Fatty Acid-Binding Proteins / physiology. Female. Humans. Insulin Resistance. Mice. Mice, Inbred C57BL. Mice, Knockout


39. Sisk J, Schweinfurth JM, Wang XT, Chong K: Presence of human papillomavirus DNA in tonsillectomy specimens. Laryngoscope; 2006 Aug;116(8):1372-4
MedlinePlus Health Information. consumer health - Tonsillitis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: The objectives of this prospective case-control study were to study the prevalence of human papillomavirus (HPV) in tonsillectomy specimens from pediatric patients without recurrent respiratory papillomatosis (RRP), and to study methods of HPV detection.
  • METHODS: Fifty pediatric patients without known RRP undergoing tonsillectomy for hypertrophy or recurrent tonsillitis were enrolled in the study.
  • Polymerase chain reaction (PCR) was performed using consensus primer pools PGMY 09/11 targeted at the L1 region.

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  • (PMID = 16885738.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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40. Khatri IA, Chaudhry US, Seikaly MG, Browne RH, Iannaccone ST: Low bone mineral density in spinal muscular atrophy. J Clin Neuromuscul Dis; 2008 Sep;10(1):11-7
MedlinePlus Health Information. consumer health - Spinal Muscular Atrophy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND PURPOSE: Pathological fractures are common in pediatric neuromuscular disorders.
  • Limited data are available on BMD in pediatric neuromuscular diseases except Duchenne muscular dystrophy.
  • METHODS: We retrospectively analyzed the results of all dual-energy x-ray absorptiometry scans done in a period of 23 months at a tertiary care pediatric neuromuscular center.
  • BMD was performed on spine region L1-4.

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  • (PMID = 18772695.001).
  • [ISSN] 1537-1611
  • [Journal-full-title] Journal of clinical neuromuscular disease
  • [ISO-abbreviation] J Clin Neuromuscul Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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41. Hafiz MG, Islam A: Extensive skeletal lesions in childhood acute lymphoblastic leukemia. Mymensingh Med J; 2009 Jan;18(1):88-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extensive skeletal lesions in childhood acute lymphoblastic leukemia.
  • Subsequently, he was transfer to Pediatric Hematology and Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU) for proper management.
  • Bone marrow aspiration findings were suggestive of ALL-L1 and cytochemistry of aspirate showed PAS positive and Sudan black negative.
  • So, an awareness of varied clinical and radiological manifestations of childhood ALL in bone marrow and skeletal system are needed in order to establish a correct diagnosis when the presenting signs and symptoms are enigmatic.


42. Diamanti A, Panetta F, Basso MS, Forgione A, Colistro F, Bracci F, Papadatou B, Francalanci P, Torroni F, Knafelz D, Fina F, Castro M: Diagnostic work-up of inflammatory bowel disease in children: the role of calprotectin assay. Inflamm Bowel Dis; 2010 Nov;16(11):1926-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSIONS: In pediatric patients with recurrent abdominal pain and changes in stool habits, a positive calprotectin assay is closely associated with IBD; its systematic employment, therefore, seems to improve the process of endoscopy referral.
  • [MeSH-major] Inflammatory Bowel Diseases / diagnosis. Leukocyte L1 Antigen Complex / analysis

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  • (PMID = 20310017.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Leukocyte L1 Antigen Complex
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43. Goksen D, Darcan S, Coker M, Kose T: Bone mineral density of healthy Turkish children and adolescents. J Clin Densitom; 2006 Jan-Mar;9(1):84-90
MedlinePlus Health Information. consumer health - Bone Density.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The results of the lumbar and femoral aBMD increased progressively from childhood to adulthood.
  • A significant increase in aBMD L1-L4 values according to puberty was observed between all Tanner stages, except Tanner stages 3 and 4 (p>0.05).

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  • (PMID = 16731436.001).
  • [ISSN] 1094-6950
  • [Journal-full-title] Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
  • [ISO-abbreviation] J Clin Densitom
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium, Dietary
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44. Lenke LG, Sides BA, Koester LA, Hensley M, Blanke KM: Vertebral column resection for the treatment of severe spinal deformity. Clin Orthop Relat Res; 2010 Mar;468(3):687-99
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The ability to treat severe pediatric and adult spinal deformities through an all-posterior vertebral column resection (VCR) has obviated the need for a circumferential approach in primary and revision surgery, but there is limited literature evaluating this new approach.
  • Forty (93%) procedures were performed at L1 or cephalad in the spinal cord (SC) territory.

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  • (PMID = 19727995.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2816784
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