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1. Orlandi A, Bianchi L, Costanzo A, Campione E, Giusto Spagnoli L, Chimenti S: Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazarotene. J Invest Dermatol; 2004 Apr;122(4):1037-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Regression was associated with reduced proliferation and increased apoptosis, demonstrated by Ki-67- and TdT-mediated dUTP-biotin nick-end labelling-positive nuclear staining, and with enhanced RAR-beta and bax expression, with RAR-alpha and -gamma expression unchanged.
  • [MeSH-major] Carcinoma, Basal Cell / drug therapy. Dermatologic Agents / therapeutic use. Nicotinic Acids / therapeutic use. Proto-Oncogene Proteins c-bcl-2. Skin Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Apoptosis. Carcinoma, Squamous Cell / drug therapy. Cell Division / drug effects. Cell Line, Tumor. Drug Administration Schedule. Humans. Middle Aged. Proto-Oncogene Proteins / metabolism. Receptors, Retinoic Acid / metabolism. Treatment Outcome. bcl-2-Associated X Protein

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  • (PMID = 15102095.001).
  • [ISSN] 0022-202X
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Dermatologic Agents; 0 / Nicotinic Acids; 0 / Proto-Oncogene Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Receptors, Retinoic Acid; 0 / bcl-2-Associated X Protein; 0 / retinoic acid receptor beta; 81BDR9Y8PS / tazarotene
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2. Koda T, Morita M, Imai H: Retinoic acid inhibits uterotrophic activity of bisphenol A in adult ovariectomized rats. J Nutr Sci Vitaminol (Tokyo); 2007 Oct;53(5):432-6
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  • [Title] Retinoic acid inhibits uterotrophic activity of bisphenol A in adult ovariectomized rats.
  • Proliferated and apoptotic uterine cells were identified by 5-bromo-2'deoxyuridine (BrdU) incorporation and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay.
  • We observed that ATRA supplementation significantly inhibits a BPA-induced uterine weight increase in adult ovariectomized rats.
  • However, there were no significant differences in the increases in the numbers of BrdU-positive cells and TUNEL-positive cells between the BPA and BPA+ATRA groups.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Free Radical Scavengers / pharmacology. Phenols / pharmacology. Tretinoin / pharmacology. Uterus / drug effects
  • [MeSH-minor] Animals. Apoptosis / drug effects. Benzhydryl Compounds. Bromodeoxyuridine. Cell Proliferation / drug effects. Dietary Supplements. Female. In Situ Nick-End Labeling. Organ Size / drug effects. Ovariectomy. Rats. Rats, Sprague-Dawley

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  • (PMID = 18079610.001).
  • [ISSN] 0301-4800
  • [Journal-full-title] Journal of nutritional science and vitaminology
  • [ISO-abbreviation] J. Nutr. Sci. Vitaminol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzhydryl Compounds; 0 / Free Radical Scavengers; 0 / Phenols; 5688UTC01R / Tretinoin; G34N38R2N1 / Bromodeoxyuridine; MLT3645I99 / bisphenol A
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3. Bulut S, Ozdemir BH, Alaaddinoĝlu EE, Oduncuoĝlu FB, Bulut OE, Demirhan B: Effect of cyclosporin A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients. J Periodontol; 2005 May;76(5):691-5
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  • [Title] Effect of cyclosporin A on apoptosis and expression of p53 and bcl-2 proteins in the gingiva of renal transplant patients.
  • Apoptosis plays an important role in the maintenance of tissue homeostasis and mediators of this process may be involved in the pathogenesis of drug-induced GO.
  • This study compared p53 expression, bcl-2 expression, and apoptosis in gingival samples from CsA-treated renal transplant recipients to findings in controls with gingivitis.
  • METHODS: Twenty-two kidney recipients with CsA-induced GO and 15 systemically healthy subjects with gingivitis were included in the study.
  • The 15 systemically and periodontally healthy volunteer control group were immunohistochemically analyzed for grades of p53 and bcl-2 expression, and were processed using terminal TdT-mediated dUTP-biotin nick-end labeling (TUNEL) technique to identify and grade levels of apoptosis.
  • There was a significant positive correlation between serum CsA level and level of bcl-2 expression, but serum CsA was not significantly correlated with level of apoptosis or level of p53 expression.
  • [MeSH-major] Apoptosis / drug effects. Cyclosporine / adverse effects. Gingival Hyperplasia / chemically induced. Immunosuppressive Agents / adverse effects. Proto-Oncogene Proteins c-bcl-2 / metabolism. Tumor Suppressor Protein p53 / metabolism
  • [MeSH-minor] Adult. Analysis of Variance. Case-Control Studies. Chi-Square Distribution. Female. Gingiva / drug effects. Gingiva / metabolism. Humans. In Situ Nick-End Labeling. Kidney Transplantation. Male. Middle Aged

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  • (PMID = 15898928.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 83HN0GTJ6D / Cyclosporine
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4. Arroyo JG, Yang L, Bula D, Chen DF: Photoreceptor apoptosis in human retinal detachment. Am J Ophthalmol; 2005 Apr;139(4):605-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Retinal tissue fragments excised during the course of vitreous surgery for RD and recurrent RD were frozen, cut into 4-mum sections, and analyzed using a TdT-dUTP terminal nick-end labeling assay for cell apoptosis.
  • All retinal tissue specimens had TUNEL-positive cells localized to the outer nuclear layer of the retina, consistent with the localization of photoreceptor cell bodies.
  • TUNEL-positive cells were first identified at 24 hours, peaked by 2 days, and dropped to a low level by 7 days after RD.
  • Recurrent RD induced a greater number of TUNEL-positive cells/mm(2) in the ONL compared with primary RD at corresponding timepoints after the onset of RD.
  • Drugs that inhibit photoreceptor apoptosis may help improve the final visual prognosis of patients with RD.
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Nucleus / pathology. Female. Humans. In Situ Nick-End Labeling. Male. Middle Aged. Prospective Studies. Recurrence. Time Factors

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  • [CommentIn] Am J Ophthalmol. 2006 Jan;141(1):227; author reply 227-8 [16387019.001]
  • (PMID = 15808154.001).
  • [ISSN] 0002-9394
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Grant] United States / PHS HHS / / K-23
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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5. Yang L, Tao T, Wang X, Du N, Chen W, Tao S, Wang Z, Wu L: Effects of dexamethasone on proliferation, differentiation and apoptosis of adult human osteoblasts in vitro. Chin Med J (Engl); 2003 Sep;116(9):1357-60
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  • [Title] Effects of dexamethasone on proliferation, differentiation and apoptosis of adult human osteoblasts in vitro.
  • OBJECTIVE: To observe the effects of dexamethasone on proliferation, differentiation and apoptosis of adult human osteoblasts in vitro.
  • METHODS: Iliac trabecular bone specimens were obtained from adult patients undergoing necessary surgery.
  • Subsequently, 10(-8) mol/L dexamethasone was added into the culture medium to incubate the osteoblasts for three days, and the cells from control groups were incubated without any drugs.
  • Finally, apoptosis was detected by the use of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and biochemical indices, alkaline phosphatase (ALP) and osteocalcin (OCN) were used to determine the effects of dexamethasone on proliferation, differentiation and apoptosis of adult osteoblasts in vitro.
  • RESULTS: In the adult osteoblasts obtained by collagenase-trypsin digestion, it achieved high survival, stable biochemical indices and excellent purification.
  • CONCLUSIONS: Dexamethasone has a significant effect on the proliferation and differentiation of adult osteoblasts in vitro without apoptosis, and dexamethasone at the suggested concentration can be used as positive control in drug studies for osteoporosis treatment.
  • [MeSH-major] Apoptosis / drug effects. Cell Differentiation / drug effects. Cell Division / drug effects. Dexamethasone / pharmacology. Osteoblasts / drug effects
  • [MeSH-minor] Adult. Cells, Cultured. Humans. In Situ Nick-End Labeling

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  • (PMID = 14527365.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 7S5I7G3JQL / Dexamethasone
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6. Uysal H, Cevik IU, Soylemezoglu F, Elibol B, Ozdemir YG, Evrenkaya T, Saygi S, Dalkara T: Is the cell death in mesial temporal sclerosis apoptotic? Epilepsia; 2003 Jun;44(6):778-84
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  • METHODS: We searched evidence for apoptotic cell death in temporal lobes resected from drug-resistant epilepsy patients with MTS by using the terminal deoxynucleotidyl transferase (TdT) and digoxigenin-11-dUTP (TUNEL) method and immunohistochemistry for Bcl-2, Bax, and caspase-cleaved actin fragment, fractin.
  • RESULTS: Unlike that in normal adult brain, we observed Bcl-2 immunoreactivity in some of the remaining neurons dispersed throughout the hippocampus proper as well as in most of the reactive astroglia.
  • CONCLUSIONS: These data suggest that either apoptosis is not involved in cell loss in MTS, or a very slow rate of cell demise may have precluded detecting TUNEL-positive neurons dying through apoptosis.
  • [MeSH-minor] Actin Cytoskeleton / ultrastructure. Adult. Age of Onset. Astrocytes / cytology. Astrocytes / pathology. Cell Count. DNA Fragmentation. Female. Hippocampus / cytology. Hippocampus / pathology. Humans. Immunohistochemistry. In Situ Nick-End Labeling / methods. Male. Neurons / cytology. Neurons / pathology. Sclerosis

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  • [CommentIn] Epilepsia. 2003 Dec;44(12):1607; author reply 1607-8 [14636340.001]
  • (PMID = 12790890.001).
  • [ISSN] 0013-9580
  • [Journal-full-title] Epilepsia
  • [ISO-abbreviation] Epilepsia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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7. Nelson LR, Hodge DO, Bourne WM: In vitro comparison of Chen medium and Optisol-GS medium for human corneal storage. Cornea; 2000 Nov;19(6):782-7
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  • After fixation, the corneal endothelium was examined by scanning electron microscopy (SEM), and TdT-dUTP terminal nick-end labeling (TUNEL) assays with 4'6-diamidino-2-phenylindole (DAPI) counterstaining were performed on tissue sections of each cornea.
  • A laser scanning confocal microscope and an automated digital analysis system were used to detect the presence of TUNEL-positive apoptotic cells in each cell layer and to determine keratocyte densities.
  • The mean percentages of TUNEL-positive cells in epithelium, stroma, and endothelium of CM-stored corneas were 4 +/- 4%, 2 +/- 3%, and 0.1 +/- 0.3%, respectively, and did not differ from the OM-stored corneal values of 4 +/- 3%, 2 +/- 4%, and 0.9 +/- 1.5%.
  • The percentage of TUNEL-positive cells did not increase with storage time.
  • The two storage media did not differ with respect to endothelial cell loss during storage or to the percentage of TUNEL-positive cells or keratocyte density at the end of the storage period.
  • [MeSH-minor] Adult. Aged. Apoptosis / drug effects. Cell Count. Chondroitin Sulfates. Complex Mixtures. Dextrans. Endothelium, Corneal / drug effects. Endothelium, Corneal / ultrastructure. Gentamicins. Humans. In Situ Nick-End Labeling. In Vitro Techniques. Middle Aged. Tissue Donors

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  • (PMID = 11095050.001).
  • [ISSN] 0277-3740
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / EY 02037
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] UNITED STATES
  • [Chemical-registry-number] 0 / Complex Mixtures; 0 / Culture Media, Serum-Free; 0 / Gentamicins; 0 / Organ Preservation Solutions; 9007-28-7 / Chondroitin Sulfates; 97794-22-4 / Optisol; K3R6ZDH4DU / Dextrans
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8. Oshitari T, Yoshida-Hata N, Yamamoto S: Effect of neurotrophic factors on neuronal apoptosis and neurite regeneration in cultured rat retinas exposed to high glucose. Brain Res; 2010 Jul 30;1346:43-51
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  • The retinas of six adult Sprague-Dawley rats were studied.
  • Then, the explants were fixed, cryosectioned, and stained by TdT-dUTP terminal nick-end labeling (TUNEL), and also immunostained for the active-forms of caspase-3 and -9.
  • The numbers of TUNEL-positive and caspase-3 and -9-immunopositive cells in the ganglion cell layer (GCL) were significantly higher, and the number of regenerating neurites was significantly lower in retinas cultured in HGM than in NG medium.
  • Retinas incubated in HGM supplemented with BDNF, NT-4, or citicoline had significantly lower numbers of TUNEL-positive and caspase-3 and -9-immunopositive cells in the GCL, and the numbers of regenerating neurites were significantly higher than in HGM without these factors.
  • [MeSH-major] Apoptosis / drug effects. Glucose / pharmacology. Nerve Growth Factors / pharmacology. Nerve Regeneration / drug effects. Neurites / drug effects. Neurons / drug effects. Retina / cytology. Retina / drug effects
  • [MeSH-minor] Animals. Caspase 3 / metabolism. Caspase 9 / metabolism. Collagen. Immunohistochemistry. In Situ Nick-End Labeling. Male. Organ Culture Techniques. Rats. Rats, Sprague-Dawley. Retinal Ganglion Cells / drug effects

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20573599.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Nerve Growth Factors; 9007-34-5 / Collagen; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 9; IY9XDZ35W2 / Glucose
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