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1. van den Brandt PA, Goldbohm RA: Nutrition in the prevention of gastrointestinal cancer. Best Pract Res Clin Gastroenterol; 2006;20(3):589-603
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  • In contrast, the roles of alcohol consumption and overweight on risk of gastrointestinal cancer have become much clearer.
  • Overweight and obesity are important risk factors for adenocarcinoma (but not squamous carcinoma) of the esophagus, gastric cardia carcinoma (but not noncardia carcinoma), and colorectal cancer, the latter in particular among men.
  • Alcohol consumption is a risk factor for squamous carcinoma (but not adenocarcinoma) of the esophagus, gastric cancer and colorectal cancer.
  • Selenium may be inversely related to esophageal and gastric cancer.
  • [MeSH-minor] Alcohol Drinking / adverse effects. Body Mass Index. Humans

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  • (PMID = 16782531.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 99
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2. Applebaum KM, McClean MD, Nelson HH, Marsit CJ, Christensen BC, Kelsey KT: Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. Int J Cancer; 2009 Jun 1;124(11):2690-6
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  • [Title] Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma.
  • Reports on the relationship between head and neck squamous cell carcinoma (HNSCC) and polymorphisms in X-ray cross complementing group 1 (XRCC1) have been inconsistent.
  • Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, sex, race, education, smoking, alcohol consumption and HPV16 serology.
  • There was no relationship between XRCC1 and HPV16-related HNSCC, regardless of smoking.

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  • (PMID = 19230024.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NIOSH CDC HHS / OH / K01 OH009390; United States / NCI NIH HHS / CA / R01 CA078609; United States / NCI NIH HHS / CA / CA078609; United States / NCI NIH HHS / CA / R01 CA100679-06A1; United States / NCI NIH HHS / CA / CA100679-06A1; United States / NCI NIH HHS / CA / CA100679; United States / NCI NIH HHS / CA / R01 CA100679; United States / NIOSH CDC HHS / OH / OH009390
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / X-ray repair cross complementing protein 1
  • [Other-IDs] NLM/ NIHMS137635; NLM/ PMC2746567
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3. Kim RH, Chang MS, Kim HJ, Song KS, Kim YS, Choi BY, Kim WH: Medical history and lifestyle factors contributing to Epstein-Barr virus-associated gastric carcinoma and conventional gastric carcinoma in Korea. Anticancer Res; 2010 Jun;30(6):2469-75
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  • [Title] Medical history and lifestyle factors contributing to Epstein-Barr virus-associated gastric carcinoma and conventional gastric carcinoma in Korea.
  • BACKGROUND: Epstein-Barr virus-associated gastric carcinoma (EBV-GC) has been characterized as a special gastric cancer subset.
  • A history of previous gastric ulcer was associated with EBV-GC, whereas frequent and heavy alcohol drinking was related to non-EBV-GC.
  • Alcohol drinking was more related to non-EBV-GC than EBV-GC.
  • [MeSH-minor] Alcohol Drinking. Female. Food Habits. Helicobacter Infections / complications. Helicobacter pylori. Humans. Male. Medical Records. Middle Aged. Risk Factors. Smoking. Socioeconomic Factors

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  • (PMID = 20651410.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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4. De Stefani E, Ronco AL, Boffetta P, Deneo-Pellegrini H, Acosta G, Mendilaharsu M: Meat consumption, meat cooking and risk of lung cancer among Uruguayan men. Asian Pac J Cancer Prev; 2010;11(6):1713-7
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  • The following potential confounders were included into the models: age, residence, hospital, education, family history of lung cancer, body mass index, smoking index, alcohol drinking, mate consumption, total energy intake, non-meat fatty foods and total fruits.
  • The mechanisms could be related to the content of N-nitroso compounds in salted meat.
  • [MeSH-major] Adenocarcinoma / etiology. Carcinoma, Small Cell / etiology. Carcinoma, Squamous Cell / etiology. Cooking. Lung Neoplasms / etiology. Meat

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  • (PMID = 21338220.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
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5. Seitz HK, Stickel F: Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem; 2006 Apr;387(4):349-60
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  • [Title] Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress.
  • Established risk factors are chronic hepatitis B and C infection, chronic heavy alcohol consumption, obesity and type 2 diabetes, tobacco use, use of oral contraceptives, and aflatoxin-contaminated food.
  • In Western countries, attributable risks are highest for cirrhosis due to chronic alcohol abuse and viral hepatitis B and C infection.
  • An important mechanism implicated in alcohol-related hepatocarcinogenesis is oxidative stress from alcohol metabolism, inflammation, and increased iron storage.
  • Furthermore, alcohol impairs the antioxidant defense system, resulting in mitochondrial damage and apoptosis.
  • Chronic alcohol exposure elicits hepatocyte hyperregeneration due to the activation of survival factors and interference with retinoid metabolism.
  • Finally, chronic alcohol abuse interferes with methyl group transfer and may thereby alter gene expression.
  • [MeSH-major] Alcohol Drinking. Carcinoma, Hepatocellular / etiology. Liver Neoplasms / etiology. Oxidative Stress

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  • (PMID = 16606331.001).
  • [ISSN] 1431-6730
  • [Journal-full-title] Biological chemistry
  • [ISO-abbreviation] Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Retinoids; 3K9958V90M / Ethanol; E1UOL152H7 / Iron; EC 1.14.13.- / Cytochrome P-450 CYP2E1
  • [Number-of-references] 140
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6. Gao C, Yao SK: Diabetes mellitus: a "true" independent risk factor for hepatocellular carcinoma? Hepatobiliary Pancreat Dis Int; 2009 Oct;8(5):465-73
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  • [Title] Diabetes mellitus: a "true" independent risk factor for hepatocellular carcinoma?
  • BACKGROUND: Diabetes mellitus (DM) is thought to be associated with an increased risk of hepatocellular carcinoma (HCC) in some published studies.
  • DATA SOURCES: MEDLINE and PubMed searches were conducted for published studies (between January 1966 and June 2009) to identify relevant articles using the keywords "diabetes", "insulin resistance" and "hepatocellular carcinoma", including "primary liver cancer".
  • (1) the significant synergy between DM, hepatitis virus infection, and heavy alcohol consumption in HCC;.
  • Related issues should be clarified by more research.
  • [MeSH-major] Carcinoma, Hepatocellular / epidemiology. Diabetes Complications / complications. Liver Neoplasms / epidemiology
  • [MeSH-minor] Alcohol Drinking / adverse effects. Hepatitis C, Chronic / complications. Humans. Risk Factors

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  • (PMID = 19822488.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Number-of-references] 41
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7. Gourin CG, Podolsky RH: Racial disparities in patients with head and neck squamous cell carcinoma. Laryngoscope; 2006 Jul;116(7):1093-106
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  • [Title] Racial disparities in patients with head and neck squamous cell carcinoma.
  • OBJECTIVES/HYPOTHESIS: Black patients are reported to have a higher incidence of advanced disease and increased mortality from head and neck squamous cell carcinoma (HNSCC) but constitute the minority of patients in large-scale studies investigating the effect of race on outcome.
  • Compared with white patients, black patients were significantly younger (mean age, 53.9 vs. 56.4 years, P<.0001), male (81.2% vs. 72.3%, P=.0005), more commonly abused alcohol (88.0% vs. 74.3%, P<.0001), and were significantly less likely to have insurance (8.6% vs. 21.7%, P<.0001).
  • Cox proportional hazards models revealed that alcohol abuse, advanced TNM stage, high tumor grade, nodal disease, extracapsular spread, advanced comorbidity, and regional or distant metastatic disease were associated with poorer survival for all patients.
  • These data suggest that racial differences in HNSCC outcomes are primarily related to differences in access to health care.
  • [MeSH-major] African Americans. Carcinoma, Squamous Cell / ethnology. European Continental Ancestry Group. Head and Neck Neoplasms / ethnology


8. Székely G, Remenár E, Kásler M, Gundy S: Mutagen sensitivity of patients with cancer at different sites of the head and neck. Mutagenesis; 2005 Sep;20(5):381-5
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  • In the aetiology of head and neck squamous cell carcinoma (HNSCC), smoking and heavy alcohol consumption are the main environmental risk factors.
  • The bleomycin (BLM) sensitivity assay is believed to measure environment-related cancer risks, mainly of HNSCC.
  • [MeSH-major] Bleomycin / toxicity. Carcinoma, Squamous Cell / genetics. Head and Neck Neoplasms / genetics. Mutagenicity Tests

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  • (PMID = 16105906.001).
  • [ISSN] 0267-8357
  • [Journal-full-title] Mutagenesis
  • [ISO-abbreviation] Mutagenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Mutagens; 11056-06-7 / Bleomycin
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9. Ding WX: Role of autophagy in liver physiology and pathophysiology. World J Biol Chem; 2010 Jan 26;1(1):3-12
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  • In addition to maintaining energy and nutrient balance in the liver, it is now clear that autophagy plays a role in liver protein aggregates related diseases, hepatocyte cell death, steatohepatitis, hepatitis virus infection and hepatocellular carcinoma.

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  • (PMID = 21540988.001).
  • [ISSN] 1949-8454
  • [Journal-full-title] World journal of biological chemistry
  • [ISO-abbreviation] World J Biol Chem
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR016475; United States / NCRR NIH HHS / RR / P20 RR021940; United States / NIAAA NIH HHS / AA / R21 AA017421
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3083930
  • [Keywords] NOTNLM ; Alcohol liver / Autophagy / Lipophagy / Mitophagy
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10. Fan JG, Farrell GC, Asia-Pacific Working Party for Prevention of Hepatocellular Carcinoma: Prevention of hepatocellular carcinoma in nonviral-related liver diseases. J Gastroenterol Hepatol; 2009 May;24(5):712-9
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  • [Title] Prevention of hepatocellular carcinoma in nonviral-related liver diseases.
  • Although chronic infection with hepatitis B virus and/or hepatitis C virus are the most important risk factors for hepatocellular carcinoma (HCC) worldwide, other causes of cirrhosis can also lead to HCC.
  • Given the high prevalence of alcoholism and the worldwide obesity epidemic, the relevant importance of nonviral liver disease-related HCC is expected to increase in the future.
  • Community-based programs to discourage and deal with excessive alcohol intake, to promote tobacco smoking awareness, to avoid exposure to aflatoxin and other food toxins, and measures to reduce the pandemic of obesity and diabetes are vital for effective interruption of the rising tide of HCC from nonviral liver disease.
  • [MeSH-major] Carcinoma, Hepatocellular / prevention & control. Liver Cirrhosis / prevention & control. Liver Neoplasms / prevention & control
  • [MeSH-minor] Alcohol Drinking / adverse effects. Alcohol Drinking / prevention & control. Androgens / adverse effects. Diabetes Mellitus, Type 2 / complications. Diabetes Mellitus, Type 2 / therapy. Diet / adverse effects. Estrogens / adverse effects. Fatty Liver / complications. Fatty Liver / therapy. Food Contamination. Health Knowledge, Attitudes, Practice. Health Promotion. Hemochromatosis / complications. Hemochromatosis / therapy. Humans. Obesity / complications. Obesity / therapy. Risk Assessment. Risk Factors. Smoking / adverse effects. Smoking / prevention & control. Water Pollutants / adverse effects

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  • (PMID = 19646014.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Androgens; 0 / Estrogens; 0 / Water Pollutants
  • [Number-of-references] 86
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11. Nagaya T, Tanaka N, Komatsu M, Ichijo T, Sano K, Horiuchi A, Joshita S, Umemura T, Matsumoto A, Yoshizawa K, Aoyama T, Kiyosawa K, Tanaka E: Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case. Clin J Gastroenterol; 2008 Oct;1(3):116-121
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  • [Title] Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case.
  • It is well recognized that NASH may develop into cirrhosis and hepatocellular carcinoma (HCC), both with unfavorable prognoses.
  • He had no history of alcohol intake and was negative for hepatitis virus markers and autoantibodies.
  • The patient's serum aminotransferase levels did not normalize despite repeated dietary instruction, and in 2001, liver histology demonstrated cirrhosis with mild steatosis and hepatocyte ballooning, leading to the diagnosis of NASH-related cirrhosis.

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  • (PMID = 26193649.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Hepatocellular carcinoma / Hyaluronic acid / Liver cirrhosis / Simple steatosis
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12. Biselli JM, de Angelo Calsaverini Leal RC, Ruiz MT, Goloni-Bertollo EM, Maníglia JV, Rossit AR, Pavarino-Bertelli EC: GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma. Braz J Otorhinolaryngol; 2006 Sep-Oct;72(5):654-8
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  • [Title] GSTT1 and GSTM1 polymorphism in cigarette smokers with head and neck squamous cell carcinoma.
  • Gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer.
  • AIM: To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers.
  • RESULTS: The oral cavity was the most prevalent tumor site for squamous cell carcinoma.
  • No association between alcohol consumption and GSTT1 and GSTMI null genotypes was found in these groups (p-values>0.05).
  • There were more men, and alcohol consumption was prevalent in both groups.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Glutathione Transferase / genetics. Head and Neck Neoplasms / genetics. Polymorphism, Genetic. Smoking / genetics

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  • (PMID = 17221058.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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13. Lyronis ID, Baritaki S, Bizakis I, Tsardi M, Spandidos DA: Evaluation of the prevalence of human papillomavirus and Epstein-Barr virus in esophageal squamous cell carcinomas. Int J Biol Markers; 2005 Jan-Mar;20(1):5-10
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  • No statistically significant correlation was found between the HPV status of the tumor samples and clinical parameters including sex, age of the patients, tobacco or alcohol use, differentiation grade of the lesions and stage of the disease.
  • In conclusion, our findings indicate a statistically significant (p<0.001) overall association between ESCC and HPV infection, mostly related to the HPV-18 subtype, in the Greek population.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / virology. Epstein-Barr Virus Infections / complications. Epstein-Barr Virus Infections / epidemiology. Esophageal Neoplasms / complications. Esophageal Neoplasms / virology. Papillomavirus Infections / complications. Papillomavirus Infections / epidemiology

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  • (PMID = 15832767.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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14. Zuccari G, Bergamante V, Carosio R, Gotti R, Montaldo PG, Orienti I: Micellar complexes of all-trans retinoic acid with polyvinylalcohol-nicotinoyl esters as new parenteral formulations in neuroblastoma. Drug Deliv; 2009 May;16(4):189-95
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  • All-trans-retinoic acid (ATRA) is now included in many antitumor therapeutic schemes for the treatment of acute promyelocytic leukemia, Kaposi's sarcoma, head and neck squamous cell carcinoma, ovarian carcinoma, bladder cancer, and neuroblastoma.
  • Unfortunately, its poor aqueous solubility hampers its parenteral formulation, whereas oral administration of ATRA is associated with progressively diminishing drug levels in plasma, which is related to induction of retinoic acid-binding proteins and increased drug catabolism by cytochrome P450-mediated reactions.
  • [MeSH-minor] Chemistry, Pharmaceutical. Drug Administration Routes. Drug Carriers / administration & dosage. Drug Carriers / chemistry. Esters / chemistry. Humans. Micelles. Polyvinyl Alcohol / chemistry. Solubility. Tumor Cells, Cultured

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  • (PMID = 19241235.001).
  • [ISSN] 1521-0464
  • [Journal-full-title] Drug delivery
  • [ISO-abbreviation] Drug Deliv
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Carriers; 0 / Esters; 0 / Micelles; 5688UTC01R / Tretinoin; 9002-89-5 / Polyvinyl Alcohol
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15. Kanazir M, Boricic I, Delic D, Tepavcevic DK, Knezevic A, Jovanovic T, Pekmezovic T: Risk factors for hepatocellular carcinoma: a case-control study in Belgrade (Serbia). Tumori; 2010 Nov-Dec;96(6):911-7
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  • [Title] Risk factors for hepatocellular carcinoma: a case-control study in Belgrade (Serbia).
  • AIMS AND BACKGROUND: The objective of this case-control study was to test the existing hypotheses about factors related to the occurrence of hepatocellular carcinoma in the population of Belgrade (Serbia).
  • METHODS AND STUDY DESIGN: The investigation was conducted between 2004 and 2007 and consisted of 45 newly diagnosed, histologically confirmed hepatocellular carcinoma patients and 90 individually gender- and age-matched hospital controls.
  • RESULTS: A highly statistically significant association (P = 0.001) was demonstrated between hepatocellular carcinoma and HBsAg positivity and the presence of hepatitis C virus antibodies.
  • Diabetes mellitus was significantly (P = 0.018) associated with an increased risk of hepatocellular carcinoma.
  • A statistically significant inverse association was shown between low parity and the risk of hepatocellular carcinoma (P = 0.033).
  • A weekly intake of fish (P = 0.003) and yogurt (P = 0.003) and daily intake of boiled vegetables (P = 0.001) were reported more frequently by controls than hepatocellular carcinoma cases.
  • In the current study, a high intake of salty food also significantly increased the risk of hepatocellular carcinoma (P = 0.027).
  • Based on multivariate analysis, the presence of hepatitis C virus antibodies (OR = 24.6, P = 0.001) and duration of smoking > or =25 years (OR = 3.8, P = 0.020) were significantly related to hepatocellular carcinoma, whereas the daily consumption of boiled vegetables (OR = 0.1, P = 0.011) was inversely associated with the risk of hepatocellular carcinoma.
  • CONCLUSIONS: The findings obtained in the current study support the hypotheses that non-viral factors, such as lifestyle factors, reproductive factors, and a history of diabetes, might be involved in the etiology of hepatocellular carcinoma.
  • [MeSH-major] Carcinoma, Hepatocellular / epidemiology. Carcinoma, Hepatocellular / etiology. Liver Neoplasms / epidemiology. Liver Neoplasms / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Alcohol Drinking / adverse effects. Case-Control Studies. Coffee / adverse effects. Comorbidity. Feeding Behavior. Female. Humans. Male. Medical History Taking. Middle Aged. Odds Ratio. Risk Factors. Serbia / epidemiology. Smoking / adverse effects

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  • (PMID = 21388051.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coffee
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16. Vairaktaris E, Yapijakis C, Nkenke E, Serefoglou ZC, Chatzitheofylaktou A, Vassiliou S, Derka S, Vylliotis A, Perrea D, Neukam FW, Patsouris E: A metalloproteinase-13 polymorphism affecting its gene expression is associated with advanced stages of oral cancer. Anticancer Res; 2007 Nov-Dec;27(6B):4027-30
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  • PATIENTS AND METHODS: The polymorphism -77A/G, which affects gene transcription, was examined in DNA samples of 161 patients with oral squamous cell carcinoma and 97 healthy controls of comparable ethnicity, age and gender.
  • The same pattern was observed between controls and patients or subgroups of patients in regard to family history of cancer, smoking and heavy alcohol consumption.
  • CONCLUSION: MMP-13 gene expression-related polymorphism is associated with risk for the highly aggressive form of oral cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Matrix Metalloproteinase 13 / genetics. Mouth Neoplasms / genetics

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  • (PMID = 18225566.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinase 13
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17. Lim YS: Current status of liver disease in Korea: hepatitis C. Korean J Hepatol; 2009 Dec;15 Suppl 6:S25-8
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  • Chronic hepatitis C (CHC) is the third most common cause of chronic liver disease and hepatocellular carcinoma (HCC) in Korea, following hepatitis B virus (HBV) infection and alcohol.
  • The mean age of patients with HCV-related cirrhosis and HCC was consistently about 10 years above that of patients associated with HBV.

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  • (PMID = 20037276.001).
  • [ISSN] 1738-222X
  • [Journal-full-title] The Korean journal of hepatology
  • [ISO-abbreviation] Korean J Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Antiviral Agents
  • [Number-of-references] 20
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18. Silva P, West CM, Slevin N, Valentine H, Ryder WD, Hampson L, Bibi R, Sloan P, Thakker N, Homer J, Hampson I: Tumor expression of major vault protein is an adverse prognostic factor for radiotherapy outcome in oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys; 2007 Sep 1;69(1):133-40
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  • [Title] Tumor expression of major vault protein is an adverse prognostic factor for radiotherapy outcome in oropharyngeal carcinoma.
  • PURPOSE: Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport, with the major vault protein (MVP or lung resistance-related protein [LRP]) being the main component.
  • Our aim was to examine this in head-and-neck squamous cell carcinoma (HNSCC).
  • METHODS AND MATERIALS: Archived biopsy material was obtained for 78 patients with squamous cell carcinoma of the oropharynx who received primary radiotherapy with curative intent.
  • After adjustment for disease site, stage, grade, anemia, smoking, alcohol, gender, and age, the estimated hazard ratio for high MVP (2/3) compared with low (0/1) was 4.98 (95% confidence interval, 2.17-11.42; p = 0.0002) for locoregional failure and 4.28 (95% confidence interval, 1.85-9.95; p = 0.001) for cancer-specific mortality.
  • [MeSH-major] Carcinoma, Squamous Cell / radiotherapy. Neoplasm Proteins / metabolism. Oropharyngeal Neoplasms / radiotherapy. Radiation Tolerance. Vault Ribonucleoprotein Particles / metabolism

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  • (PMID = 17459603.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Multidrug Resistance-Associated Proteins; 0 / Neoplasm Proteins; 0 / Vault Ribonucleoprotein Particles; 0 / major vault protein
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19. Schnitzer SE, Weigert A, Zhou J, Brüne B: Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Mol Cancer Res; 2009 Mar;7(3):393-401
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  • Hypoxia and signaling via hypoxia-inducible factor-1 (HIF-1) is a key feature of solid tumors and is related to tumor progression as well as treatment failure.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / metabolism. Lung Neoplasms / metabolism. Lysophospholipids / metabolism. Phosphotransferases (Alcohol Group Acceptor) / metabolism. Sphingosine / analogs & derivatives

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  • (PMID = 19240180.001).
  • [ISSN] 1541-7786
  • [Journal-full-title] Molecular cancer research : MCR
  • [ISO-abbreviation] Mol. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media; 0 / Lysophospholipids; 0 / RNA, Small Interfering; 0 / Receptors, Lysosphingolipid; 26993-30-6 / sphingosine 1-phosphate; 6PLQ3CP4P3 / Etoposide; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.- / sphingosine kinase; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; NGZ37HRE42 / Sphingosine
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20. Singh R, Kaul R, Kaul A, Khan K: A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol; 2007 Mar 28;13(12):1770-87
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  • Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC).
  • The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in relation to susceptibility, viral persistence and treatment.
  • HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations.

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  • (PMID = 17465466.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / HLA Antigens; 0 / Viral Vaccines
  • [Number-of-references] 159
  • [Other-IDs] NLM/ PMC4149952
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21. Gale N, Michaels L, Luzar B, Poljak M, Zidar N, Fischinger J, Cardesa A: Current review on squamous intraepithelial lesions of the larynx. Histopathology; 2009 May;54(6):639-56
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  • SILs are caused by smoking and alcohol abuse.
  • Transition from normal epithelium to SILs and squamous cell carcinoma is related to progressive accumulation of genetic changes leading to a clonal population of transformed epithelial cells.

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  • (PMID = 18752537.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 189
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22. Stefos A, Gatselis N, Zachou K, Rigopoulou E, Hadjichristodoulou C, Dalekos GN: Descriptive epidemiology of chronic hepatitis B by using data from a hepatitis registry in Central Greece. Eur J Intern Med; 2009 Jan;20(1):35-43
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  • RESULTS: 187/303 patients (61.7%) classified as chronic inactive HBV carriers, 78/303 (25.7%) had chronic hepatitis B, 29/303 (9.6%) had HBV-related cirrhosis and 9/303 (3%) HBV-related hepatocellular carcinoma (HCC).
  • Alcohol abuse was the only independent factor (OR: 2.5; p=0.01) associated with the progression to cirrhosis-HCC.
  • Alcohol abuse is frequent among HBV patients and is acting as an effect modificator risk factor for the development of HBV-related cirrhosis and HCC.
  • [MeSH-minor] Adult. Age Distribution. Aged. Carcinoma, Hepatocellular / epidemiology. Child. Female. Geographic Information Systems. Greece / epidemiology. Humans. Liver Cirrhosis / epidemiology. Liver Neoplasms / epidemiology. Male. Medicine, Traditional. Middle Aged. Prevalence. Risk Factors. Young Adult

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  • (PMID = 19237090.001).
  • [ISSN] 1879-0828
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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23. Fujishima T, Ishikawa T, Shiratori Y, Kanda M, Tateishi R, Akamatsu M, Koike Y, Sato S, Obi S, Hamamura K, Teratani T, Shiina S, Yoshida H, Kawabe T, Omata M: Age-related comparison of the profiles of patients with hepatocellular carcinoma. Hepatogastroenterology; 2006 Nov-Dec;53(72):913-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Age-related comparison of the profiles of patients with hepatocellular carcinoma.
  • BACKGROUND/AIMS: It is not known whether the putative etiologic factors and clinical and pathological features of hepatocellular carcinoma differ between young adults and older patients.
  • Younger patients also had a higher ratio of alcohol consumption compared to elderly patients.
  • CONCLUSIONS: There were age-related differences in the clinicopathological characteristics of HCC patients.
  • Of the HCV-related HCC patients, heavy drinking may accelerate the progression from chronic hepatitis to cirrhosis and HCC.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Carcinoma, Hepatocellular / pathology. Liver Neoplasms / etiology. Liver Neoplasms / pathology

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  • (PMID = 17153452.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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24. Manekeller S, Sauerbruch T, Fischer HP, Propping P, Hirner A: [Heterozygous alpha-1-antitrypsin deficiency (PiMZ): risk factor in the development of primary liver carcinoma in non-cirrhotic liver?]. Z Gastroenterol; 2010 Oct;48(10):1211-4
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  • [Title] [Heterozygous alpha-1-antitrypsin deficiency (PiMZ): risk factor in the development of primary liver carcinoma in non-cirrhotic liver?].
  • Here we report on a patient with a primary hepatocellular carcinoma in a non-cirrhotic liver, in whom heterozygosity for an AAT-deficiency allele was found (PiMZ).
  • Based on this observation and the current literature, the possible mechanisms for an eventual contribution of a heterozygosity of a heterozygous AAT-deficiency for a hepatocellular carcinoma are discussed.
  • Alpha-1-antitrypsin (AAT)-deficiency (Laurell-Eriksson syndrome) is a genetic disorder, in which individuals who are homozygous for a deficiency allele are at an increased lifetime risk for pulmonary emphysema, liver cirrhosis, and primary hepatocellular carcinoma.
  • Since not all patients with precipitates of AAT-aggregates are develop a hepatocellular carcinoma related comorbidities such as chronic hepatitis B, C, chronic alcohol abuse, or so far unknown genetic and environmental factors may be crucial.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Genetic Predisposition to Disease / genetics. Liver Neoplasms / genetics. Loss of Heterozygosity / genetics. Polymorphism, Single Nucleotide / genetics. alpha 1-Antitrypsin / genetics


25. Xue KX: [Molecular genetic and epigenetic mechanisms of hepatocarcinogenesis]. Ai Zheng; 2005 Jun;24(6):757-68
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  • Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the most frequent human malignant neoplasms.
  • Common risk factors of human HCC include chronic hepatitis virus (HBV and HCV) infection, dietary aflatoxin B1 (AFB1) ingestion, chronic alcohol abuse, and cirrhosis associated with genetic liver diseases.
  • The roles of some important genes related to cell apoptosis, DNA repair, drug metabolism, and tumor metastasis in hepatocarcinogenesis had been discussed.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Liver Neoplasms / genetics. Retinoblastoma Protein / metabolism. Tumor Suppressor Protein p53 / metabolism. Wnt Proteins / metabolism


26. Murakami A, Fukushima C, Yositomi K, Sueoka K, Nawata S, Fujimoto M, Nakamura K, Sugino N: Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase. Int J Oncol; 2010 Jun;36(6):1395-400
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase.
  • Squamous cell carcinoma antigen (SCCA) is a useful tumor marker for diagnosis and management of squamous cell carcinoma.
  • Third, Western blotting was performed to analyze the expression levels of this protein in keratinocytes and six kinds of uterine squamous cell carcinoma cell lines.
  • The CR expression levels in six kinds of squamous cell carcinoma cell lines were lower compared to those in keratinocytes.
  • [MeSH-major] Alcohol Oxidoreductases / metabolism. Antigens, Neoplasm / metabolism. Epithelial Cells / immunology. Keratinocytes / metabolism. Serpins / metabolism
  • [MeSH-minor] Blotting, Western. Carcinoma, Squamous Cell / metabolism. Cell Line, Tumor. Cytoplasm / metabolism. Humans. Immunohistochemistry. Immunoprecipitation

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  • (PMID = 20428762.001).
  • [ISSN] 1791-2423
  • [Journal-full-title] International journal of oncology
  • [ISO-abbreviation] Int. J. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Serpins; 0 / squamous cell carcinoma-related antigen; EC 1.1.- / Alcohol Oxidoreductases
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27. Zuccari G, Carosio R, Fini A, Montaldo PG, Orienti I: Modified polyvinylalcohol for encapsulation of all-trans-retinoic acid in polymeric micelles. J Control Release; 2005 Mar 21;103(2):369-80
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  • All-trans-retinoic acid (ATRA) is now included in many antitumor therapeutic schemes for the treatment of acute promyelocytic leukaemia, Kaposi's sarcoma, head and neck squamous cell carcinoma, ovarian carcinoma, bladder cancer and neuroblastoma.
  • To date, there is no parenteral formulation of ATRA commercially available and oral administration of ATRA is associated with progressively diminishing ATRA levels in plasma, which is related to induction of retinoic acid-binding protein and increased drug catabolism by cytochrome P-450-mediated reaction.
  • [MeSH-major] Antineoplastic Agents / chemistry. Drug Compounding. Polyvinyl Alcohol / chemistry. Tretinoin / chemistry

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  • (PMID = 15763620.001).
  • [ISSN] 0168-3659
  • [Journal-full-title] Journal of controlled release : official journal of the Controlled Release Society
  • [ISO-abbreviation] J Control Release
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amines; 0 / Antineoplastic Agents; 0 / Micelles; 5688UTC01R / Tretinoin; 9002-89-5 / Polyvinyl Alcohol; ZDQ1JWQ8DT / oleylamine
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28. Asia-Pacific Working Party on Prevention of Hepatocellular Carcinoma: Prevention of hepatocellular carcinoma in the Asia-Pacific region: consensus statements. J Gastroenterol Hepatol; 2010 Apr;25(4):657-63
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  • [Title] Prevention of hepatocellular carcinoma in the Asia-Pacific region: consensus statements.
  • Among approximately 650,000 people who die from hepatocellular carcinoma (HCC) each year, at least two-thirds live in Asia.
  • Separate reviews have summarized epidemiology of HCC, preventive approaches related to hepatitis B virus (HBV), hepatitis C virus (HCV) and non-viral liver diseases, and the role of surveillance to detect HCC at a curative stage.
  • There is currently insufficient evidence to give firm recommendations on alcohol, obesity/metabolic risk factors and other liver diseases.
  • [MeSH-major] Carcinoma, Hepatocellular / prevention & control. Hepatitis B, Chronic / prevention & control. Hepatitis C, Chronic / prevention & control. Liver Neoplasms / prevention & control. Mass Screening. Primary Prevention

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  • (PMID = 20492323.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Practice Guideline; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Hepatitis B Vaccines
  • [Investigator] Farrell GC; Chan HL; Yuen MF; Amarapurkar DN; Chutaputti A; Fan JG; Hou JL; Han KH; Kao JH; Lim SG; Mohamed R; Sollano J; Ueno Y
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29. Castro MA, Dedivitis RA, Ribeiro KC: Comorbidity measurement in patients with laryngeal squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec; 2007;69(3):146-52
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  • [Title] Comorbidity measurement in patients with laryngeal squamous cell carcinoma.
  • OBJECTIVE: It was the aim of this study to measure comorbidities in patients with laryngeal squamous cell carcinoma.
  • PATIENTS AND METHODS: Ninety adult patients treated for newly diagnosed laryngeal squamous cell carcinoma were studied.
  • We measured comorbid illness applying the following validated scales: the Cumulative Illness Rating Scale (CIRS), the Kaplan-Feinstein Classification (KFC), the Charlson index, the Index of Coexistent Disease (ICED), the Adult Comorbidity Evaluation-27 (ACE-27), the Alcohol-Tobacco-Related Comorbidities Index (ATC), and the Washington University Head and Neck Comorbidity Index (WUHNCI).
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Laryngeal Neoplasms / epidemiology

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  • [Copyright] Copyright (c) 2007 S. Karger AG, Basel.
  • (PMID = 17264530.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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30. Loko MA, Salmon D, Carrieri P, Winnock M, Mora M, Merchadou L, Gillet S, Pambrun E, Delaune J, Valantin MA, Poizot-Martin I, Neau D, Bonnard P, Rosenthal E, Barange K, Morlat P, Lacombe K, Gervais A, Rouges F, See AB, Lascoux-Combe C, Vittecoq D, Goujard C, Duvivier C, Spire B, Izopet J, Sogni P, Serfaty L, Benhamou Y, Bani-Sadr F, Dabis F, ANRS CO 13 HEPAVIH Study Group: The French national prospective cohort of patients co-infected with HIV and HCV (ANRS CO13 HEPAVIH): early findings, 2006-2010. BMC Infect Dis; 2010;10:303
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  • Longitudinal studies addressing clinical and public health questions related to HIV-HCV co-infection (HIV-HCV clinical progression and its determinants including genetic dimension, patients' experience with these two diseases and their treatments) are limited.
  • As of January, 2010, after a median follow-up of 16.7 months (IQR: 11.3-25.3), 13 new cases of decompensated cirrhosis, nine hepatocellular carcinomas and 20 HCV-related deaths were reported, resulting in a cumulative HCV-related severe event rate of 1.9/100 person-years (95% CI: 1.3-2.5).
  • The rate of HCV-related severe events was higher in cirrhotic patients and those with a low CD4 cells count, but did not differ according to sex, age, alcohol consumption, CDC clinical stage or HCV status.
  • [MeSH-minor] Adult. Anti-HIV Agents / therapeutic use. Antiretroviral Therapy, Highly Active. CD4 Lymphocyte Count. Carcinoma, Hepatocellular / epidemiology. Disease Progression. Female. France / epidemiology. HIV-1 / isolation & purification. Hepacivirus / isolation & purification. Humans. Liver Neoplasms / epidemiology. Longitudinal Studies. Male. Medication Adherence. Middle Aged. RNA, Viral / blood. Risk Factors. Surveys and Questionnaires. Viral Load

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  • (PMID = 20969743.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC2988047
  • [Investigator] Salmon D; Dabis F; Winnock M; Loko MA; Sogni P; Benhamou Y; Trimoulet P; Izopet J; Paradis V; Spire B; Carrieri P; Katlama C; Pialoux G; Valantin MA; Bonnard P; Poizot-Martin I; Marchou B; Rosenthal E; Bicart See A; Djebbar R; Gervais A; Lascoux-Combe C; Goujard C; Lacombe K; Duvivier C; Vittecoq D; Neau D; Morlat P; BaniSadr F; Meyer L; Boufassa F; Dominguez S; Autran B; Roque AM; Solas C; Fontaine H; Serfaty L; Chêne G; Costagliola D; Couffin-Cadiergues S; Salmon D; Sogni P; Terris B; Makhlouf Z; Dubost G; Tessier F; Gibault L; Beuvon F; Chambon E; Lazure T; Krivine A; Katlama C; Valantin MA; Dominguez S; Benhamou Y; Charlotte F; Fourati S; Poizot-Martin I; Zaegel O; Ménard A; Tamalet C; Pialoux G; Bonnard P; Bani-Sadr F; Callard P; Bendjaballah F; Assami H; Marchou B; Alric L; Barange K; Metivier S; Rosenthal E; Pradier C; Haudebourg J; Saint-Paul MC; Rouges F; Djebbar R; Ziol M; Baazia Y; Uzan M; Bicart-See A; Garipuy D; Nicot F; Yéni P; Gervais A; Adle-Biassette H; Séréni D; Lascoux Combe C; Bertheau P; Duclos J; Palmer P; Girard PM; Lacombe K; Campa P; Wendum D; Cervera P; Adam J; Harchi N; Delfraissy JF; Goujard C; Quertainmont Y; Pallier C; Vittecoq D; Lortholary O; Duvivier C; Boucly S; Neau D; Morlat P; Raymond I; Louis I; Bioulac-Sage P; Trimoulet P; Pinson P; Beniken D; Ritleng AS; Fooladi A; Azar M; Honoré P; Breau S; Serini L; Mole M; Malet M; Bolliot C; Touam F; Mellul S; Alexandre G; Ganon A; Thirrée S; Gillet S; Delaune J; Dequae Merchadou L; Pambrun E; Frosch A; Cohen J; Cohen J; Kurkdji P; Loko MA; Winnock M
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31. Malekzadeh K, Sobti RC, Nikbakht M, Shekari M, Hosseini SA, Tamandani DK, Singh SK: Methylation patterns of Rb1 and Casp-8 promoters and their impact on their expression in bladder cancer. Cancer Invest; 2009 Jan;27(1):70-80
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  • We tried to determine the methylation status and its impact on the expression of two tumor related genes Casp-8 and Rb1 in 103 bladder tumor tissues and 48 control paraffin-embedded tissues by using MSP-PCR and SQRT-PCR.
  • The risk of bladder cancer was marginally associated in drinker patients (OR = 1.78, 95% CI = 1.42-2.24, p = 0.010) featuring both genes methylated, especially in those patients consumed alcohol units>30 per week (OR = 4.57, 95% CI = 2.38-8.80, p = 0.000).
  • [MeSH-major] Carcinoma, Transitional Cell / genetics. Caspase 8 / genetics. DNA Methylation. Gene Expression Regulation, Neoplastic. Promoter Regions, Genetic / genetics. Retinoblastoma Protein / genetics. Urinary Bladder Neoplasms / genetics
  • [MeSH-minor] Alcohol Drinking. Case-Control Studies. DNA, Neoplasm / genetics. Female. Humans. Male. Middle Aged. Neoplasm Staging. Polymerase Chain Reaction. Prognosis. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. Regulatory Sequences, Nucleic Acid. Reverse Transcriptase Polymerase Chain Reaction. Smoking

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  • (PMID = 19160091.001).
  • [ISSN] 1532-4192
  • [Journal-full-title] Cancer investigation
  • [ISO-abbreviation] Cancer Invest.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / Retinoblastoma Protein; EC 3.4.22.- / CASP8 protein, human; EC 3.4.22.- / Caspase 8
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32. Lacko M, Oude Ophuis MB, Peters WH, Manni JJ: Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility. Anticancer Res; 2009 Feb;29(2):753-61
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  • [Title] Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility.
  • Smoking and the consumption of alcohol are the main risk factors for head and neck cancer.
  • [MeSH-major] Carcinogens / pharmacokinetics. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / genetics. Head and Neck Neoplasms / enzymology. Head and Neck Neoplasms / genetics. Smoking / genetics. Smoking / metabolism

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  • (PMID = 19331232.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Carcinogens; EC 2.4.1.17 / Glucuronosyltransferase; EC 2.5.1.18 / Glutathione Transferase; EC 3.3.2.- / Epoxide Hydrolases
  • [Number-of-references] 45
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33. Wiese M, Grüngreiff K, Güthoff W, Lafrenz M, Oesen U, Porst H, East German Hepatitis C Study Group: Outcome in a hepatitis C (genotype 1b) single source outbreak in Germany--a 25-year multicenter study. J Hepatol; 2005 Oct;43(4):590-8
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  • Ten (0.5%) died of HCV related complications, half of these related to additional comorbidity.
  • [MeSH-minor] Adult. Age of Onset. Alcohol Drinking. Carcinoma, Hepatocellular / epidemiology. Disease Outbreaks. Female. Genotype. Germany / epidemiology. Humans. Liver Cirrhosis / epidemiology. Liver Neoplasms / epidemiology. Male. Middle Aged. Risk Factors. Viral Load

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  • [CommentIn] J Hepatol. 2005 Oct;43(4):550-2 [16099527.001]
  • (PMID = 16237783.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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34. Powell EE, Jonsson JR, Clouston AD: Steatosis: co-factor in other liver diseases. Hepatology; 2005 Jul;42(1):5-13
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  • Steatosis, obesity, and associated metabolic factors may also modulate the response to alcohol- and drug-induced liver disease and may be risk factors for the development of hepatocellular cancer.
  • The pathogenesis of injury in obesity-related fatty liver disease involves a number of pathways, which are currently under investigation.
  • [MeSH-minor] Apoptosis. Carcinoma, Hepatocellular / etiology. Carcinoma, Hepatocellular / physiopathology. Disease Progression. Humans. Liver Cirrhosis / etiology. Liver Cirrhosis / physiopathology. Liver Neoplasms / etiology. Liver Neoplasms / physiopathology. Metabolic Syndrome X / complications. Metabolic Syndrome X / physiopathology. Oxidative Stress

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  • (PMID = 15962320.001).
  • [ISSN] 0270-9139
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 103
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35. Otoh EC, Johnson NW, Mandong BM, Danfillo IS: Primary head and neck cancers in Jos, Nigeria: a re-visit. West Afr J Med; 2006 Apr-Jun;25(2):92-100
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  • AIDS-related cancers constituted 12.3% of all head and neck cancers and were commonly reported in the 3rd decade of life.
  • Carcinomas were associated with alcohol use and tobacco smoking (p<0.001), while kaposi sarcoma was more associated with HIV-positive patients than squamous cell carcinoma (p=0.016).

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  • (PMID = 16918178.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Nigeria
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36. Marur S, D'Souza G, Westra WH, Forastiere AA: HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol; 2010 Aug;11(8):781-9
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  • [Title] HPV-associated head and neck cancer: a virus-related cancer epidemic.
  • A rise in incidence of oropharyngeal squamous cell cancer--specifically of the lingual and palatine tonsils--in white men younger than age 50 years who have no history of alcohol or tobacco use has been recorded over the past decade.
  • By contrast, tobacco-related oropharyngeal cancer is characterised by TP53 mutation and downregulation of CDKN2A (encoding P16).
  • For example, why does the increase in HPV-related oropharyngeal cancer dominate in men?
  • Our aim with this review is to highlight current understanding of the epidemiology, biology, detection, and management of HPV-related oropharyngeal head and neck squamous cell carcinoma, and to describe unresolved issues.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Human papillomavirus 16. Oropharyngeal Neoplasms / virology. Papillomavirus Infections / complications. Tumor Virus Infections / complications

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  • [Copyright] 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20451455.001).
  • [ISSN] 1474-5488
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE021395
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 75
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37. Werner R, Manthey KC, Griffin JB, Zempleni J: HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium. J Nutr Biochem; 2005 Oct;16(10):617-24
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  • Here we investigated short-term effects of moderately riboflavin-deficient culture medium on flavin-related responses in HepG2 hepatocarcinoma cells.

  • Hazardous Substances Data Bank. Riboflavin .
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  • (PMID = 16081269.001).
  • [ISSN] 0955-2863
  • [Journal-full-title] The Journal of nutritional biochemistry
  • [ISO-abbreviation] J. Nutr. Biochem.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK060447; United States / NIDDK NIH HHS / DK / R01 DK063945; United States / NIDDK NIH HHS / DK / DK 063945; United States / NIDDK NIH HHS / DK / DK 60447
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCAAT-Enhancer-Binding Proteins; 0 / Culture Media; 0 / DDIT3 protein, human; 0 / NF-kappa B; 0 / Transcription Factors; 147336-12-7 / Transcription Factor CHOP; 9007-49-2 / DNA; EC 1.8.1.7 / Glutathione Reductase; EC 2.7.1.- / Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.26 / riboflavin kinase; EC 2.7.7.- / Nucleotidyltransferases; EC 2.7.7.2 / FMN adenylyltransferase; TLM2976OFR / Riboflavin
  • [Other-IDs] NLM/ NIHMS5875; NLM/ PMC1373781
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38. Willem P, Brown J, Schouten J: A novel approach to simultaneously scan genes at fragile sites. BMC Cancer; 2006;6:205
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  • A FHIT/WWOX MLPA assay was designed, applied and validated in five esophageal squamous cell carcinoma ESCC, cell lines established in South Africa where this cancer is of high prevalence.
  • Simultaneous scanning of FHIT and WWOX exons in the context of early tumorigenesis and tumor progression, may help clarify the mechanistic events related to cancer development which are not revealed by immuno histochemistry assays.
  • [MeSH-minor] Acid Anhydride Hydrolases / genetics. Carcinoma / genetics. Chromosome Deletion. Chromosomes, Human, Pair 16. Chromosomes, Human, Pair 3. DNA Probes. Esophageal Neoplasms / genetics. Female. Gene Dosage. Humans. In Situ Hybridization, Fluorescence. Male. Neoplasm Proteins / genetics. Oxidoreductases / genetics. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured. Tumor Suppressor Proteins

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  • (PMID = 16895604.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Probes; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Proteins; 0 / fragile histidine triad protein; EC 1.- / Oxidoreductases; EC 1.1.1.- / WWOX protein, human; EC 3.6.- / Acid Anhydride Hydrolases
  • [Other-IDs] NLM/ PMC1569856
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39. Ikeda K, Marusawa H, Osaki Y, Nakamura T, Kitajima N, Yamashita Y, Kudo M, Sato T, Chiba T: Antibody to hepatitis B core antigen and risk for hepatitis C-related hepatocellular carcinoma: a prospective study. Ann Intern Med; 2007 May 1;146(9):649-56
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  • [Title] Antibody to hepatitis B core antigen and risk for hepatitis C-related hepatocellular carcinoma: a prospective study.
  • BACKGROUND: Previous exposure to hepatitis B virus (HBV) and occult HBV infection may have an important role in the development of hepatocellular carcinoma (HCC) in patients with chronic liver disease related to hepatitis C virus (HCV).
  • OBJECTIVE: To prospectively study the association between antibody to hepatitis B core antigen (anti-HBc) and clinical outcomes in patients with HCV-related chronic liver disease.
  • Hepatocellular carcinoma occurred in 237 of 846 patients (28.0%) during follow-up.
  • Among patients with cirrhosis, HCC was diagnosed in 85 of 141 patients (60.3%) with anti-HBc and 58 of 129 patients (45.0%) without HBV-related serologic markers.
  • LIMITATIONS: The study included only 1 assessment of smoking and alcohol consumption at study entry and did not precisely determine the duration of smoking or alcohol use.
  • CONCLUSIONS: Anti-HBc-positive results on serologic testing are a marker of high risk for HCC among patients with HCV-related cirrhosis.
  • [MeSH-major] Carcinoma, Hepatocellular / virology. Hepatitis B Antibodies / blood. Hepatitis B Core Antigens / immunology. Hepatitis C, Chronic / immunology. Liver Neoplasms / virology

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  • [CommentIn] Ann Intern Med. 2008 Jan 15;148(2):166-7; author reply 167 [18195343.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2007 May 1;146(9):I59 [17470828.001]
  • (PMID = 17470833.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Hepatitis B Antibodies; 0 / Hepatitis B Core Antigens; 0 / Interferon-alpha; 77238-31-4 / Interferon-beta
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40. Cruz MJ, Alves S, Baudrier T, Azevedo F: Porphyria cutanea tarda induced by tamoxifen. Dermatol Online J; 2010;16(9):2
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  • In the sporadic form, the decrease in the activity is restricted to the liver and is generally related to alcohol, estrogens, iron overload, hepatitis C infection, and halogenated aromatic hydrocarbons.
  • [MeSH-minor] Breast Neoplasms / drug therapy. Carcinoma, Ductal / drug therapy. Female. Humans. Middle Aged

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  • (PMID = 20875323.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen
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41. Potash AE, Karnell LH, Christensen AJ, Vander Weg MW, Funk GF: Continued alcohol use in patients with head and neck cancer. Head Neck; 2010 Jul;32(7):905-12
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  • [Title] Continued alcohol use in patients with head and neck cancer.
  • BACKGROUND: The effect of posttreatment alcohol consumption on health-related quality of life (QOL) and factors predicting overall QOL and continued alcohol consumption were examined in patients with head and neck cancer.
  • METHODS: Self-reported alcohol use and abuse 1 year after diagnosis was analyzed.
  • Oral function was the only predictor of 12-month alcohol use.
  • Alcohol consumption was not associated with QOL, but was associated with better oral function, which in turn predicted better QOL.
  • Alcohol consumption itself does not improve QOL in this population, and these patients should be counseled regarding detrimental effects of continued drinking after treatment.
  • [MeSH-major] Alcohol Drinking / epidemiology. Alcoholism / epidemiology. Carcinoma / psychology. Head and Neck Neoplasms / psychology. Quality of Life

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc.
  • (PMID = 19918984.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA106908
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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42. Katase N, Gunduz M, Beder L, Gunduz E, Lefeuvre M, Hatipoglu OF, Borkosky SS, Tamamura R, Tominaga S, Yamanaka N, Shimizu K, Nagai N, Nagatsuka H: Deletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas. Oncol Res; 2008;17(6):273-82
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  • [Title] Deletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomas.
  • Head and neck squamous cell carcinoma (HNSCC) is a frequently occurring cancer, and despite improvement of its treatment methods, including chemotherapy, radiotherapy, and surgery, the improvement of survival remains poor.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Intercellular Signaling Peptides and Proteins / genetics. Sequence Deletion
  • [MeSH-minor] Age Factors. Aged. Alcohol Drinking. Female. Genetic Predisposition to Disease. Humans. Kaplan-Meier Estimate. Loss of Heterozygosity. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Proportional Hazards Models. Risk Factors. Sex Factors. Smoking

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  • (PMID = 19192722.001).
  • [ISSN] 0965-0407
  • [Journal-full-title] Oncology research
  • [ISO-abbreviation] Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DKK3 protein, human; 0 / Intercellular Signaling Peptides and Proteins
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43. Ronis DL, Duffy SA, Fowler KE, Khan MJ, Terrell JE: Changes in quality of life over 1 year in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg; 2008 Mar;134(3):241-8
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  • MAIN OUTCOME MEASURE: Health-related QOL was assessed using the 36-item Short-Form Health Survey and a head and neck cancer-specific QOL scale.
  • CONCLUSIONS: Health-related physical QOL tended to decline over 1 year and mental health QOL improved.
  • [MeSH-major] Carcinoma, Squamous Cell / psychology. Head and Neck Neoplasms / psychology. Quality of Life
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Alcohol Drinking / epidemiology. Depression / epidemiology. Female. Humans. Linear Models. Longitudinal Studies. Male. Middle Aged. Prospective Studies. Risk Factors. Smoking / epidemiology. Surveys and Questionnaires

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  • (PMID = 18347247.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA97248
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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44. El-Refaei MF, El-Naa MM: Inhibitory effect of caffeic acid phenethyl ester on mice bearing tumor involving angiostatic and apoptotic activities. Chem Biol Interact; 2010 Jul 30;186(2):152-6
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  • In order to substantiate this fact implanted tumor Ehrlich carcinoma cells were assessed in vivo to Swiss mice strain.
  • This inhibition may be related to its angiostatic and apoptotic effects.
  • [MeSH-major] Caffeic Acids / pharmacology. Carcinoma, Ehrlich Tumor / drug therapy. Phenylethyl Alcohol / analogs & derivatives

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  • [Copyright] (c) 2010 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 20433813.001).
  • [ISSN] 1872-7786
  • [Journal-full-title] Chemico-biological interactions
  • [ISO-abbreviation] Chem. Biol. Interact.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Caffeic Acids; 0 / Endostatins; EC 3.4.24.- / Mmp9 protein, mouse; EC 3.4.24.35 / Matrix Metalloproteinase 9; G960R9S5SK / caffeic acid phenethyl ester; ML9LGA7468 / Phenylethyl Alcohol
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45. Cui R, Kamatani Y, Takahashi A, Usami M, Hosono N, Kawaguchi T, Tsunoda T, Kamatani N, Kubo M, Nakamura Y, Matsuda K: Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. Gastroenterology; 2009 Nov;137(5):1768-75
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  • [Title] Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
  • BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is prevalent among Asian populations, with marked regional variations in incidence and mortality.
  • Multiple logistic regression analysis revealed SNP rs671, rs1229984, alcohol drinking, and smoking as the independent risk factors for ESCC (odds ratios of 1.66, 1.85, 1.92, and 1.79, respectively).
  • Moreover, individuals who had both genetic and lifestyle-related risk factors had a nearly 190 times higher risk of ESCC than those who had neither of these.
  • CONCLUSIONS: We found 2 known functional variants involved in the metabolism of alcohol and tobacco by-products as the most significant risk factors for the development of ESCC in a Japanese population.
  • [MeSH-major] Alcohol Dehydrogenase / genetics. Alcohol Drinking. Aldehyde Dehydrogenase / genetics. Carcinoma, Squamous Cell / genetics. Esophageal Neoplasms / genetics. Polymorphism, Single Nucleotide / genetics. Smoking


46. Giannitrapani L, Soresi M, La Spada E, Cervello M, D'Alessandro N, Montalto G: Sex hormones and risk of liver tumor. Ann N Y Acad Sci; 2006 Nov;1089:228-36
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  • Long-term use of oral contraceptives (OCs) and anabolic androgenic steroids (AASs) can induce both benign (hemangioma, adenoma, and focal nodular hyperplasia [FNH]) and malignant (hepatocellular carcinoma [HCC]) hepatocellular tumors.
  • Hepatic adenomas (HAs) are rare, benign neoplasms usually occurring in young women, the development and the complications of which have been related to the strength of OCs and the duration of their use.
  • Apart from liver cirrhosis, numerous other factors responsible for its onset have been proposed: hepatitis infections from virus B (HBV) and C (HCV), alcohol, smoking, and aflatoxin.

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  • (PMID = 17261770.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gonadal Steroid Hormones; 0 / Receptors, Androgen; 0 / Receptors, Estrogen
  • [Number-of-references] 38
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47. Hassan MM, Spitz MR, Thomas MB, El-Deeb AS, Glover KY, Nguyen NT, Chan W, Kaseb A, Curley SA, Vauthey JN, Ellis LM, Abdalla E, Lozano RD, Patt YZ, Brown TD, Abbruzzese JL, Li D: Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study. Int J Cancer; 2008 Oct 15;123(8):1883-91
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  • [Title] Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study.
  • The International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC).
  • Use of smokeless tobacco (chewing tobacco and snuff), cigars, pipes and passive smoking exposure were not related to HCC among noncigarette smokers.
  • Heavy alcohol consumption was associated with HCC in women: AOR, 7.7 (95% CI, 2.3-25.1).
  • Cigarette smoking interacted synergistically with chronic infection of hepatitis C virus in men: AOR, 136.3 (95% CI, 43.2-429.6) and with heavy alcohol consumption in women: AOR, 13.7 (95% CI, 3.2-57.9).
  • We conclude that sex differences were observed in HCC relationship with cigarette smoking and alcohol consumption.

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  • (PMID = 18688864.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / K07 CA106458-04; United States / NCI NIH HHS / CA / K07 CA106458; United States / NCI NIH HHS / CA / CA106458-04; United States / NIEHS NIH HHS / ES / R03 ES11481; United States / NCI NIH HHS / CA / CA106458-01; United States / NIEHS NIH HHS / ES / R03 ES011481
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tobacco Smoke Pollution
  • [Other-IDs] NLM/ NIHMS93249; NLM/ PMC2673571
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48. Toner M, O'Regan EM: Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1. Head Neck Pathol; 2009 Sep;3(3):246-8
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  • [Title] Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1.
  • While most head and neck squamous carcinoma (HNSCC) occurs in older people, an increasing number of young patients are being affected worldwide, with up to 5.5% <40.
  • Part of this trend appears to be due to rising numbers of HPV associated tonsil carcinoma, particularly in males (smokers and non-smokers).
  • A subset of young patients, however, is non-smoking females usually with tongue cancers, not related to HPV, the aetiology of which is unclear.
  • Various mechanisms may be at work here: the variation in ability to detoxify the products of smoke and alcohol varies in individuals, which may explain why environmental exposure to smoke seems to play a role in some non-smokers with HNSCC.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / etiology. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / etiology

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  • (PMID = 20596979.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
  • [Other-IDs] NLM/ PMC2811623
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49. Song LH, Duy DN, Binh VQ, Luty AJ, Kremsner PG, Bock CT: Low frequency of mutations in the X gene, core promoter and precore region of hepatitis B virus infected Vietnamese. J Viral Hepat; 2005 Mar;12(2):160-7
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  • None of the study participants had a history of alcohol or drug use and none received any antiviral or immunosuppressive therapy before or during the course of this study.
  • In the study, 4/48 hepatocellular carcinoma (HCC) patients revealed truncated HBx, whilst the serine to alanine mutation (codon 31) of HBx was more prevalent in cancer patients than in asymptomatic HBV carriers (P < 0.01).
  • The exclusively found prevalence of certain mutations detected in those with HBV-related carcinoma nevertheless indicates a degree of association with disease progression.

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  • (PMID = 15720531.001).
  • [ISSN] 1352-0504
  • [Journal-full-title] Journal of viral hepatitis
  • [ISO-abbreviation] J. Viral Hepat.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Genetic Markers; 0 / Hepatitis B Core Antigens
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50. Rosenthal E, Salmon-Céron D, Lewden C, Bouteloup V, Pialoux G, Bonnet F, Karmochkine M, May T, François M, Burty C, Jougla E, Costagliola D, Morlat P, Chêne G, Cacoub P, Mortavic/Mortalité 2005 Study Group: Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 study in collaboration with the Mortalité 2005 survey, ANRS EN19). HIV Med; 2009 May;10(5):282-9
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  • [Title] Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 study in collaboration with the Mortalité 2005 survey, ANRS EN19).
  • Results Among 287 reported deaths in 2005, 100 (35%) were related to AIDS, and 48 (17%) to ESLD.
  • Three out of four patients who died from ESLD-related causes had chronic hepatitis C.
  • Excessive alcohol consumption was reported in approximately half of the patients (48%).
  • The proportion of deaths caused by hepatocellular carcinoma increased from 5% in 1995 to 25% in 2005 (P=0.0337).
  • CONCLUSIONS: Over the 10 years from 1995 to 2005, the proportion of deaths caused by hepatitis C virus-related ESLD has increased in HIV-infected patients.
  • ESLD is currently a leading cause of death in this population, with hepatocellular carcinoma representing a quarter of liver-related deaths.
  • Recommendations for the detection of hepatocellular carcinoma should be strictly applied in these patients.
  • [MeSH-major] Carcinoma, Hepatocellular / mortality. HIV Infections / mortality. Hepatitis C, Chronic / mortality. Liver Neoplasms / mortality
  • [MeSH-minor] Acquired Immunodeficiency Syndrome / complications. Acquired Immunodeficiency Syndrome / mortality. Adult. Aged. Alcohol Drinking / mortality. Antiretroviral Therapy, Highly Active. CD4 Lymphocyte Count. Cause of Death / trends. Cross-Sectional Studies. Female. France / epidemiology. Humans. Liver Cirrhosis, Alcoholic / complications. Liver Cirrhosis, Alcoholic / mortality. Male. Middle Aged. Prospective Studies. alpha-Fetoproteins / analysis

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  • (PMID = 19226410.001).
  • [ISSN] 1468-1293
  • [Journal-full-title] HIV medicine
  • [ISO-abbreviation] HIV Med.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
  • [Investigator] Pautard-Huchemblé B; Schmit JL; Bonnefoy M; Bru JP; Gaillat J; Lerousseau L; Dubois D; Azzedine A; De La Blanchardière A; Lepeu G; Faller JP; Balvay P; Barale F; Estavoyer JM; Vuitton D; Bentata M; Cohen P; Guillevin L; Jarrousse B; Padrazzi B; Beylot J; Bernard N; Constans J; Loury I; Moreau F; Morlat P; Ragnaud JM; Viaud JF; Lacoste D; Baglin A; Dorra M; Dupont C; Hanslik T; Rouveix E; Granier P; Cénac A; Bazin C; Hazera P; Verdon R; Schmidt J; Rogeaux O; Menalba C; Boué F; Fior R; Galanaud P; Pik JJ; Beytout J; Laurichesse H; Ruivard M; Laplatte G; Audoy B; Plaisance N; Bouterra C; Laylotte G; Delarocque E; Vinceneux P; Lesprit P; Schaeffer A; Grappin M; Greuzard MC; Loudes-Chauvin MC; Portier H; Vinceneux M; Guillaumie J; Dournovo P; De Truchis P; Perronne C; Bouchard O; Micoud M; Morand P; Boucher J; Chambourlier P; Renou C; Arvin-Berod C; Poubeau P; Perre P; Hachulla E; Devulder B; Hatron PY; Loustaud-Ratti V; Berthou JD; Baborier D; Constant E; Dufay E; Peyramond D; Trémolières F; Bourgeade A; Durand JM; Gastaut JA; Gallais H; Moreau J; Perret JL; Poizot-Martin I; Soubeyrand J; Meissonnier P; Hayek R; Constant C; Raabe JJ; Wang A; Astruc J; Blanc F; Perney P; Vandôme A; Bautoille D; Guerbois C; Loyau C; Raffi F; Villers D; Burty C; Canton P; de Korwin JD; Thibaut G; Wahl D; Dellamonica P; Cassuto JP; Ceppi C; Fuzibet JG; Poirée M; Pradier C; Rosenthal E; Raffanel C; Amoura Z; Aumaitre H; Bani-Sadr F; Bergmann JF; Bissuel F; Boissonnas A; Bouvet E; Bricaire F; Cabane J; Cabié A; Cacoub P; Caquet R; Carbon C; Caulin C; Chemlal K; Coulaud JP; de Beaumont T; Devars du Mayne F; Dupont C; Durand B; Farge D; Galanaud P; Gaudebout C; Gilquin J; Goujard C; Hausfater P; Katlama C; Karmochkine M; Krainik F; Le Bras P; Le Moing V; Leport C; Modaï J; Molina JM; Pialoux G; Piette JC; Poinsignon Y; Quertainmont Y; Raguin G; Rozenbaum W; Sicard D; Simon J; Vachon F; Valleron AJ; Vildé JL; Arsac P; Calamy G; Mille C; Mercie P; Pellegrin JL; Becq-Giraudon B B; Breux JP; Le Moal G; Michelet C; Cartier F; Beguinot I; Rémy G; Gueit I; Borsa-Lebas F; Humbert G; Wemeau J; Hascouet C; Le Cam B; Khuong MA; Mechali D; Roblin X; Defontaine C; Lucht F; Fégueux S; Veyssier-Belot C; Ouzan D; Kitschke B; Clément-Bertoldo C; Gonzales G; Poubeau P; Fischer P; Lang JM; Rey D; Ruellan A; Schlienger JL; Zucman D; Blétry O; Romand P; Alric L; Cuzin L; Duffaut M; Ajana F; Mouton Y; Yazdanpanah Y; Borderon JC; Choutet P; Guimard Y; Patey O
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51. Luo RH, Zhao ZX, Zhou XY, Gao ZL, Yao JL: Risk factors for primary liver carcinoma in Chinese population. World J Gastroenterol; 2005 Jul 28;11(28):4431-4
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  • [Title] Risk factors for primary liver carcinoma in Chinese population.
  • AIM: To evaluate the risk factors for primary liver carcinoma (PLC) in Chinese population.
  • All the related literatures were screened, and the risk factors for PLC in Chinese population were studied.
  • Ten factors related to PLC were demonstrated by sensitive analysis and funnel plot analysis.
  • CONCLUSION: The main risk factors for PLC in China are liver diseases, family history of liver carcinoma, poor psychic status, aflatoxin, and some unhealthy behaviors.
  • [MeSH-minor] Alcohol Drinking / epidemiology. China / epidemiology. Family Health. Food Contamination. Health Behavior. Humans. Risk Factors

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  • (PMID = 16038048.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 5
  • [Other-IDs] NLM/ PMC4434676
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52. Díaz de Liaño A, Artieda C, Yárnoz C, Garde C, Flores L, Ortiz H: Esophageal squamous cell carcinoma after liver transplantation. Clin Transl Oncol; 2005 Dec;7(11):518-20
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  • [Title] Esophageal squamous cell carcinoma after liver transplantation.
  • The occurrence of an oesophageal squamous cell carcinoma following liver transplantation is very infrequent.
  • Such an event has been related to a history of alcohol-induced cirrhosis, as in other squamous cell tumours of the oropharynx.
  • We report the case of a 64-year-old male patient diagnosed as having oesophageal squamous cell carcinoma six years after having had a liver transplant due to alcohol-induced cirrhosis.
  • [MeSH-major] Alcoholism / complications. Carcinoma, Squamous Cell / etiology. Cardia / pathology. Esophageal Neoplasms / etiology. Immunosuppression / adverse effects. Immunosuppressive Agents / adverse effects. Liver Transplantation. Neoplasms, Multiple Primary / etiology. Postoperative Complications / etiology. Stomach Neoplasms / etiology. Tacrolimus / adverse effects


53. Kim SR, Ikawa H, Ando K, Mita K, Fuki S, Sakamoto M, Kanbara Y, Matsuoka T, Kudo M, Hayashi Y: Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis. World J Gastroenterol; 2007 Feb 28;13(8):1271-4
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  • [Title] Multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated hepatocellular carcinoma in a patient with alcohol-related liver cirrhosis.
  • We describe a rare case of the transformation of a dysplastic nodule into well-differentiated hepato-cellular carcinoma (HCC) in a 56-year-old man with alcohol-related liver cirrhosis.
  • This is the first case of multistep hepatocarcinogenesis from a dysplastic nodule to well-differentiated HCC within one year in alcohol-related liver cirrhosis.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Cell Transformation, Neoplastic. Liver Cirrhosis, Alcoholic / pathology. Liver Neoplasms / pathology

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  • (PMID = 17451213.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4147007
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54. Vairaktaris E, Vylliotis A, Spyridonodou S, Derka S, Vassiliou S, Nkenke E, Yapijakis C, Serefoglou Z, Neukam FW, Patsouris E: A DNA polymorphism of stromal-derived factor-1 is associated with advanced stages of oral cancer. Anticancer Res; 2008 Jan-Feb;28(1A):271-5
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  • BACKGROUND: Stromal derived factor-1 (SDF-1), a protein related to angiogenesis and inflammation, has been correlated with the progression of a number of malignancies, but not with oral squamous cell carcinoma.
  • PATIENTS AND METHODS: The G801A polymorphism was examined by restriction fragment length polymorphism analysis in DNA samples from 159 patients with oral squamous cell carcinoma and 101 matched healthy controls.
  • RESULTS: The detected allele frequency of the "high production related" A allele in the control group was 25.3%.
  • Interestingly, in comparison to controls, the A allele frequency was significantly lower in patients with advanced cancer stages III and IV (12.5%, p=0.005) and in patients with alcohol abuse (12.5%, p=0.02).
  • CONCLUSION: The G801A polymorphism of the SDF-1 gene is associated with advanced stages of oral cancer, especially in alcohol abusers.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Chemokine CXCL12 / genetics. Mouth Neoplasms / genetics

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  • (PMID = 18383856.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Chemokine CXCL12; 0 / DNA, Neoplasm
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55. Zhou L, Huang Y, Li J, Wang Z: The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma. Med Oncol; 2010 Jun;27(2):255-61
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  • [Title] The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma.
  • This study was conducted to determine the status of the mTOR pathway in human hepatocellular carcinoma (HCC) and to investigate its relationship with the prognosis of HCC.
  • CONCLUSION: Expression of the mTOR pathway components, which are related with the transferability and invasive capacity of HCC cells, may be used as prognostic indicators in HCC.
  • [MeSH-major] Biomarkers, Tumor / physiology. Carcinoma, Hepatocellular / diagnosis. Carcinoma, Hepatocellular / enzymology. Liver Neoplasms / diagnosis. Liver Neoplasms / enzymology. Signal Transduction / physiology. TOR Serine-Threonine Kinases / physiology

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  • (PMID = 19301157.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.1.1 / MTOR protein, human; EC 2.7.1.1 / TOR Serine-Threonine Kinases; EC 2.7.1.137 / Phosphatidylinositol 3-Kinase; EC 3.1.3.67 / PTEN Phosphohydrolase; EC 3.1.3.67 / PTEN protein, human
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56. Suzuki T, Matsuo K, Hiraki A, Saito T, Sato S, Yatabe Y, Mitsudomi T, Hida T, Ueda R, Tajima K: Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study. Carcinogenesis; 2007 Aug;28(8):1718-25
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  • [Title] Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.
  • None of the polymorphisms showed any significant impact on lung cancer overall risk by genotype alone, but on histology-based analysis increase in MTHFR 677T and 1,298C alleles was associated with reduced risk of squamous/small cell carcinoma (P = 0.029), especially among heavy smokers (P = 0.035), whereas the MTHFR 677TT genotype was linked to decreased risk for these subtypes among heavy drinkers (odds ratio = 0.17, 95% confidence interval: 0.03-0.98).
  • In addition, we found interactions between the MTRR A66G polymorphism and smoking (P = 0.015) and the MTHFR A1,298C polymorphism and alcohol consumption (P = 0.025) for risk of lung cancer overall.
  • In conclusion, the results suggest that MTHFR polymorphisms contribute to risk of squamous/small cell carcinomas of the lung, along with possible interactions among folate metabolism-related polymorphisms and smoking/drinking habits.
  • [MeSH-minor] Adenocarcinoma / genetics. Adolescent. Adult. Aged. Carcinoma, Large Cell / genetics. Carcinoma, Small Cell / genetics. Carcinoma, Squamous Cell / genetics. Case-Control Studies. Female. Humans. Japan. Male. Methylenetetrahydrofolate Reductase (NADPH2) / genetics. Methylenetetrahydrofolate Reductase (NADPH2) / metabolism. Middle Aged. Random Allocation. Risk Factors

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  • (PMID = 17468511.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 935E97BOY8 / Folic Acid; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2)
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57. Gramenzi A, Conti F, Felline F, Cursaro C, Riili A, Salerno M, Gitto S, Micco L, Scuteri A, Andreone P, Bernardi M: Hepatitis C Virus-related chronic liver disease in elderly patients: an Italian cross-sectional study. J Viral Hepat; 2010 May;17(5):360-6
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  • [Title] Hepatitis C Virus-related chronic liver disease in elderly patients: an Italian cross-sectional study.
  • Comparison of younger and older groups showed that 51% patients > or =65 years had advanced liver disease (liver cirrhosis or hepatocellular carcinoma) compared with 26% younger patients (P < 0.0001).
  • By multivariate analysis, age > or = 65 years, alcohol consumption and diabetes were independently associated with advanced liver disease.
  • [MeSH-minor] Adult. Aged. Antiviral Agents / therapeutic use. Carcinoma, Hepatocellular / epidemiology. Cross-Sectional Studies. Female. Hepatitis C Antibodies / blood. Humans. Italy / epidemiology. Liver Cirrhosis / epidemiology. Liver Neoplasms / epidemiology. Male. Middle Aged. Prevalence. RNA, Viral / blood. Risk Factors. Young Adult

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  • (PMID = 19758274.001).
  • [ISSN] 1365-2893
  • [Journal-full-title] Journal of viral hepatitis
  • [ISO-abbreviation] J. Viral Hepat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Hepatitis C Antibodies; 0 / RNA, Viral
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58. Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Takahashi I, Chayama K: Risk factors for hepatocellular carcinoma in a Japanese population: a nested case-control study. Cancer Epidemiol Biomarkers Prev; 2008 Apr;17(4):846-54
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  • [Title] Risk factors for hepatocellular carcinoma in a Japanese population: a nested case-control study.
  • BACKGROUND: Epidemiologic studies have shown effects of lifestyle-related factors on risk for hepatocellular carcinoma.
  • METHODS: We conducted a nested case-control study using sera stored before hepatocellular carcinoma diagnosis in the longitudinal cohort of atomic bomb survivors.
  • The study included 224 hepatocellular carcinoma cases and 644 controls that were matched to the cases on gender, age, city, time of serum storage, and method of serum storage, and countermatched on radiation dose.
  • RESULTS: Univariate analysis showed that HBV and HCV infections, alcohol consumption, smoking habit, body mass index (BMI), and diabetes mellitus were associated with increased hepatocellular carcinoma risk, whereas coffee drinking was associated with decreased hepatocellular carcinoma risk.
  • Multivariate relative risks of hepatocellular carcinoma (95% confidence interval) were 45.8 (15.2-138), 101 (38.7-263), 70.7 (8.3-601), 4.36 (1.48-13.0), and 4.57 (1.85-11.3), for HBV infection alone, HCV infection alone, both HBV and HCV infections, alcohol consumption of > or =40 g of ethanol per day, and BMI of >25.0 kg/m(2) 10 years before diagnosis, respectively.
  • Among HCV-infected individuals, the relative risk of hepatocellular carcinoma for a 1 kg/m(2) increase in BMI was 1.39 (P = 0.003).
  • CONCLUSIONS: To limit the risk for hepatocellular carcinoma, control of excess weight may be crucial for individuals with chronic liver disease, especially those with chronic hepatitis C.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Hepacivirus / isolation & purification. Hepatitis B virus / isolation & purification. Liver Neoplasms / etiology

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  • (PMID = 18398026.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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59. Gelatti U, Covolo L, Talamini R, Tagger A, Barbone F, Martelli C, Cremaschini F, Franceschi S, Ribero ML, Garte S, Nardi G, Donadon V, Donato F: N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study. Int J Cancer; 2005 Jun 10;115(2):301-6
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  • [Title] N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study.
  • Our aim was to evaluate the role of N-acetyltransferase (NAT2) and glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphisms in hepatocellular carcinoma (HCC) according to cigarette smoking, taking into account hepatitis B (HBV) and C (HCV) viral infection as well as alcohol consumption.
  • Cases (n = 200) were patients hospitalized for HCC, and controls (n = 400) were patients admitted for reasons other than liver disease, neoplasms and tobacco- and alcohol-related diseases.
  • [MeSH-major] Arylamine N-Acetyltransferase / genetics. Carcinoma, Hepatocellular / genetics. Glutathione Transferase / genetics. Liver Neoplasms / genetics. Polymorphism, Genetic. Smoking / adverse effects

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 15688397.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.3.1.5 / Arylamine N-Acetyltransferase; EC 2.3.1.5 / NAT2 protein, human; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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60. Peters ES, McClean MD, Liu M, Eisen EA, Mueller N, Kelsey KT: The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. Cancer Epidemiol Biomarkers Prev; 2005 Feb;14(2):476-82
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  • [Title] The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use.
  • Alcohol consumption interacts with tobacco use to increase the risk of head and neck squamous cell carcinoma (HNSCC).
  • Alcohol is eliminated through oxidation by alcohol dehydrogenase (ADH).
  • This polymorphism has been reported to alter the risk of HNSCC associated with alcohol use, although the literature differs in the estimates of both the magnitude and direction of this effect modification.
  • There was a significant interaction of alcohol use and genotype (P = 0.05), with an estimated oral cancer risk in heavy drinkers of 7.1 (95% CI, 2.3-22.0) for homozygous variants compared with an OR of 2.3 (95% CI, 1.4-3.8) for ADH1C homozygous wild type or heterozygous individuals (controlling for smoking, age, race, and gender).
  • These findings suggest that the ADH1C*2-2 genotype is associated with susceptibility to smoking and drinking-related HNSCC by modifying the biologically effective dose of alcohol.
  • [MeSH-major] Alcohol Dehydrogenase / genetics. Alcohol Drinking / adverse effects. Carcinoma, Squamous Cell / genetics. Head and Neck Neoplasms / genetics. Smoking / adverse effects

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  • (PMID = 15734975.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA78609; United States / NIEHS NIH HHS / ES / ES 00002
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase
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61. Paradela S, Pita-Fernández S, Peña C, Fernández-Jorge B, García-Silva J, Mazaira M, Fonseca E: Complications of ambulatory major dermatological surgery in patients older than 85 years. J Eur Acad Dermatol Venereol; 2010 Oct;24(10):1207-13
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  • Studied variables were age, gender, tobacco-alcohol exposure, co-morbid medical conditions, blood-thinning medication, antibiotic prophylaxis, number of lesions, location, histopathological diagnosis, area of skin removed, surgical technique, type of flap, length of surgery, entrance order, suture thread, surgical complications and need of post-operative admission.
  • The most frequent tumour was basal cell carcinoma (45.1%), followed by squamous cell carcinoma (38.7%) and melanoma (8.3%).
  • Length of surgical procedure, area of skin removed and reconstruction with skin-graft were significantly related to higher risk of post-operative complications.
  • [MeSH-minor] Aged, 80 and over. Carcinoma, Basal Cell / surgery. Carcinoma, Squamous Cell / surgery. Cellulitis / etiology. Cellulitis / pathology. Female. Humans. Male. Melanoma / surgery. Necrosis / etiology. Necrosis / pathology. Retrospective Studies. Spain. Treatment Outcome

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  • [Copyright] © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.
  • (PMID = 20337810.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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62. McKillop IH, Schrum LW: Role of alcohol in liver carcinogenesis. Semin Liver Dis; 2009 May;29(2):222-32
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  • [Title] Role of alcohol in liver carcinogenesis.
  • Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and contributes significantly to cancer-related morbidity and mortality.
  • Chronic alcohol consumption has long been associated with progressive liver disease toward the development of hepatic cirrhosis and the subsequent increased risk for developing HCC.
  • In assessing the role of alcohol during hepatic disease, and as a carcinogen, many of the deleterious effects of alcohol can be attributed to alcohol metabolism in hepatocytes.
  • In addition to the direct effects of alcohol/alcohol metabolism on hepatocyte transformation, increasing evidence indicates that other intrahepatic and systemic effects of alcohol are likely to play an equally significant role in the process of hepatic tumorigenesis.
  • [MeSH-major] Alcohol Drinking / adverse effects. Carcinoma, Hepatocellular / etiology. Ethanol / toxicity. Liver / drug effects. Liver Diseases, Alcoholic / etiology. Liver Neoplasms / etiology

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  • (PMID = 19387921.001).
  • [ISSN] 1098-8971
  • [Journal-full-title] Seminars in liver disease
  • [ISO-abbreviation] Semin. Liver Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; GO1N1ZPR3B / Acetaldehyde
  • [Number-of-references] 146
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63. Sagnelli E, Stroffolini T, Mele A, Almasio P, Coppola N, Ferrigno L, Scolastico C, Onofrio M, Imparato M, Filippini P: The importance of HCV on the burden of chronic liver disease in Italy: a multicenter prevalence study of 9,997 cases. J Med Virol; 2005 Apr;75(4):522-7
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  • A total of 9,997 patients were recruited, of whom 939 (9.4%) had normal liver biochemistry, 6,210 (62.1%) had chronic hepatitis, 1,940 (19.4%) had liver cirrhosis, and 341 (3.4%) had hepatocellular carcinoma (HCC).
  • A history of alcohol abuse was found in 23% of the cases (9.4% without viral infection).
  • The prevalence of HCV-related cases was significantly lower in incident than in prevalent cases (44.9% vs. 59.9%, P < 0.0001), while the proportion of patients with alcohol abuse was much higher in incident than in prevalent cases (18.1% vs. 6.6%, P < 0.0001).
  • [MeSH-minor] Adult. Aged. Alcoholism / complications. Carcinoma, Hepatocellular / epidemiology. Carcinoma, Hepatocellular / etiology. Chronic Disease / epidemiology. Female. Hepacivirus. Hepatitis B / complications. Hepatitis B / epidemiology. Hepatitis B virus. Humans. Incidence. Italy / epidemiology. Liver Cirrhosis / epidemiology. Liver Cirrhosis / etiology. Liver Neoplasms / epidemiology. Liver Neoplasms / etiology. Male. Middle Aged. Prevalence. Risk Factors

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15714480.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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64. Greving JP, Lee JE, Wolk A, Lukkien C, Lindblad P, Bergström A: Alcoholic beverages and risk of renal cell cancer. Br J Cancer; 2007 Aug 6;97(3):429-33
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  • Compared to non-drinkers, a total ethanol intake of >620 g month(-1) was significantly related to a decreased risk of renal cell cancer (odds ratio (OR) 0.6, 95% confidence interval (CI) 0.4-0.9; P-value for trend=0.03).
  • [MeSH-major] Alcohol Drinking. Beverages. Carcinoma, Renal Cell / epidemiology. Kidney Neoplasms / epidemiology

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  • (PMID = 17653076.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2360322
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65. Chatzimichalis M, Xenellis J, Tzagaroulakis A, Sarof P, Banis K, Gazouli M, Bibas A: GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population. J Laryngol Otol; 2010 Mar;124(3):318-23
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  • [Title] GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek population.
  • OBJECTIVE: It is well known that laryngeal squamous cell carcinoma is strongly related to tobacco and alcohol consumption.
  • Accumulating evidence suggests that alterations of detoxification enzymes, such as glutathione S-transferases and N-acetyltransferases, influence the risk of cancers associated with tobacco smoke and alcohol.
  • The study group consisted of 88 Greek patients with laryngeal squamous cell carcinoma; there were also 102 control subjects.
  • CONCLUSION: This study demonstrated a significant relationship between rapid acetylator genotypes and laryngeal squamous cell carcinoma in a Greek population.
  • [MeSH-major] Arylamine N-Acetyltransferase / genetics. Carcinoma, Squamous Cell / genetics. Glutathione Transferase / genetics. Laryngeal Neoplasms / genetics
  • [MeSH-minor] Acetylation. Aged. Alcohol Drinking / adverse effects. Case-Control Studies. Female. Gene Frequency. Genetic Predisposition to Disease. Greece / epidemiology. Humans. Isoenzymes / genetics. Male. Middle Aged. Phenotype. Polymerase Chain Reaction / methods. Polymorphism, Genetic / genetics. Retrospective Studies. Smoking / adverse effects

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  • (PMID = 19922706.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isoenzymes; EC 2.3.1.5 / Arylamine N-Acetyltransferase; EC 2.3.1.5 / NAT2 protein, human; EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1; EC 2.5.1.18 / glutathione transferase M3-3
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66. Ndububa DA, Ojo OS, Adetiloye VA, Aladegbaiye AO, Adebayo RA, Adekanle O: The contribution of alcohol to chronic liver disease in patients from South-west Nigeria. Niger J Clin Pract; 2010 Dec;13(4):360-4
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  • [Title] The contribution of alcohol to chronic liver disease in patients from South-west Nigeria.
  • OBJECTIVE: This study aimed at determining the level and type of alcohol consumed by patients diagnosed with chronic liver disease (CLD) and, hence, the extent to which alcohol may have contributed to the development of the condition.
  • Alcohol consumption was considered significant if a patient took >50 g/day for > 10 years.
  • Fifty-one (35.2%) patients, all males, drank significant alcohol while consumption was not significant in 43 (29.6%) patients.
  • Alcohol was not consumed at all by 51 (35.2%) patients made up of 18 males (35.3%) and 33 females (64.7%).
  • Beer was the commonest form of alcohol consumed (70.2%) followed by palm wine (50%) and locally-brewed gin (20.2%).
  • The diagnoses made were liver cirrhosis [LC] (60, 41.38%), chronic hepatitis [CH] (54, 37.20%), hepatocellular carcinoma [HCC] (23, 15.86%), alcoholic liver disease [ALD] (6, 4.14%) and non-alcoholic fatty liver disease [NAFLD] (2, 1.38%).
  • The liver disease spectrum did not differ between the patients who drank significant alcohol and those who did not.
  • However, the proportion of LC/HCC cases increased relative to CH with increasing age and consumption of alcohol.
  • CONCLUSIONS: The proportion of CLD directly attributable to alcohol (i.e.
  • However, the burden of LC and HCC is directly related to age and the amount of alcohol consumed and the determinants of alcohol abuse are gender and affluence.
  • [MeSH-major] Alcohol Drinking / adverse effects. Liver Diseases, Alcoholic / diagnosis. Liver Diseases, Alcoholic / epidemiology

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  • (PMID = 21220846.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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67. Kraunz KS, McClean MD, Nelson HH, Peters E, Calderon H, Kelsey KT: Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma. Cancer Res; 2006 Apr 15;66(8):4512-5
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  • [Title] Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma.
  • In tobacco-associated solid tumors, evidence suggests that the pattern of carcinogen exposure is related to the nature of somatic gene inactivation within crucial pathways, including the retinoblastoma (Rb) pathway.
  • One somatic event in this pathway, homozygous deletion of the p16INK4A gene, is commonly observed in head and neck squamous cell carcinoma (HNSCC).
  • Alcohol and tobacco are both well-established risk factors for HNSCC but there has been little characterization of the relationship of exposure to these carcinogens and inactivation of the p16INK4A gene.
  • Hypothesizing that p16INK4A homozygous deletion is associated with tobacco and alcohol exposure, we investigated 330 consecutive HNSCC tumors.
  • The odds ratio (OR) for p16INK4A homozygous deletion among alcohol consumers in the upper tertile (>43 years used) was 5.2 [95% confidence interval (95% CI), 2.1-12.8] as compared with those with < or = 43 years of alcohol consumption.
  • Intensity of alcohol exposure, measured as average alcoholic drinks per week, was not associated with gene deletion.
  • As in the case of alcohol use, intensity of tobacco exposure (measured as packs per day) was not associated with gene deletion.
  • Hence, the duration of alcohol use and duration of smoking, but not intensity of either, significantly predicted p16(INK4A) homozygous deletion in HNSCC.
  • [MeSH-major] Alcohol Drinking / adverse effects. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Head and Neck Neoplasms / etiology. Head and Neck Neoplasms / genetics. Smoking / adverse effects

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  • (PMID = 16618779.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES00002; United States / NCI NIH HHS / CA / R01 CA078609; United States / NCI NIH HHS / CA / R01 CA100679; United States / NIEHS NIH HHS / ES / T32ES07155
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
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68. Lee CH, Wu DC, Lee JM, Wu IC, Goan YG, Kao EL, Huang HL, Chan TF, Chou SH, Chou YP, Ho CK, Wu MT: Anatomical subsite discrepancy in relation to the impact of the consumption of alcohol, tobacco and betel quid on esophageal cancer. Int J Cancer; 2007 Apr 15;120(8):1755-62
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  • [Title] Anatomical subsite discrepancy in relation to the impact of the consumption of alcohol, tobacco and betel quid on esophageal cancer.
  • We carried out a multicenter case-control study in Taiwan to assess anatomical subsite risk discrepancy for this neoplasm in regard to the consumption of alcohol, tobacco and betel quid.
  • All consumption of the three substances was related to the development of each subsite of EC, with a heterogeneously higher risk for current smokers (adjusted odds ratio (AOR) = 6.2) found in M/3-EC and for current chewers, in U/3-EC (AOR = 4.9).
  • In conclusion, tumor subsite discrepancy risk is related to prolonged exposure to tobacco and betel quid with inflorescence.
  • Alcohol interacts with tobacco in a stronger supra-multiplicative way in the middle portion of the esophagus, probably explaining why esophageal SCC occurs more commonly at this anatomical location.
  • [MeSH-major] Alcohol Drinking / adverse effects. Areca / adverse effects. Carcinoma, Squamous Cell / etiology. Esophageal Neoplasms / etiology. Smoking / adverse effects


69. Vasavi M, Vedicherala B, Vattam KK, Ahuja YR, Hasan Q: Assessment of genetic damage in inflammatory, precancerous, and cancerous pathologies of the esophagus using the comet assay. Genet Test Mol Biomarkers; 2010 Aug;14(4):477-82
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  • The interindividual variation observed was independent of confounding factors such as tobacco and alcohol.
  • We suggest that the damage seen in the esophageal tissue is likely to be disease-related, whereas that seen in blood may be a reflection of disease.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Comet Assay / methods. DNA Damage. Esophageal Neoplasms / genetics. Esophagitis / genetics. Precancerous Conditions / genetics

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  • (PMID = 20632893.001).
  • [ISSN] 1945-0257
  • [Journal-full-title] Genetic testing and molecular biomarkers
  • [ISO-abbreviation] Genet Test Mol Biomarkers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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70. Islami F, Kamangar F, Nasrollahzadeh D, Møller H, Boffetta P, Malekzadeh R: Oesophageal cancer in Golestan Province, a high-incidence area in northern Iran - a review. Eur J Cancer; 2009 Dec;45(18):3156-65
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  • Oesophageal squamous cell carcinoma (OSCC) constitutes over 90% of all OC cases in Golestan.
  • Alcohol is consumed by a very small percentage of the population and is not a risk factor for OSCC in this area.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Esophageal Neoplasms / epidemiology. Smoking / adverse effects
  • [MeSH-minor] Alcohol Drinking / adverse effects. Alcohol Drinking / epidemiology. Alphapapillomavirus / isolation & purification. Asia / epidemiology. Female. Hot Temperature / adverse effects. Humans. Iran / epidemiology. Male. Malnutrition / complications. Opioid-Related Disorders / complications. Opioid-Related Disorders / epidemiology. Polymorphism, Genetic / genetics. Risk Factors. Tobacco, Smokeless / adverse effects. Turkmenistan / ethnology. Water Supply

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  • (PMID = 19800783.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] England
  • [Number-of-references] 86
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71. Saneto H, Kobayashi M, Kawamura Y, Yatsuji H, Sezaki H, Hosaka T, Akuta N, Suzuki F, Suzuki Y, Arase Y, Ikeda K, Kumada H: Clinicopathological features, background liver disease, and survival analysis of HCV-positive patients with hepatocellular carcinoma: differences between young and elderly patients. J Gastroenterol; 2008;43(12):975-81
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  • [Title] Clinicopathological features, background liver disease, and survival analysis of HCV-positive patients with hepatocellular carcinoma: differences between young and elderly patients.
  • BACKGROUND: The aim of this retrospective study was to determine the incidence and characteristics of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) antibody-positive elderly patients with chronic hepatitis without cirrhosis.
  • CONCLUSIONS: Our results showed distinct differences in HCV-related HCC between elderly and young patients and suggested that elderly patients (especially women) could develop HCC even when liver histology shows chronic hepatitis and lack of cirrhosis.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Hepatitis C, Chronic / complications. Liver Neoplasms / pathology

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  • (PMID = 19107342.001).
  • [ISSN] 0944-1174
  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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72. Horton PJ, Tchervenkov J, Barkun JS, Rochon C, Chaudhury PK, Znajda TL, Martinie JB, Metrakos P: Antithymocyte globulin induction therapy in hepatitis C-positive liver transplant recipients. J Gastrointest Surg; 2005 Sep-Oct;9(7):896-902
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  • Second, third, and fourth grafts were excluded, as were patients with stage III or IV hepatocellular carcinoma.
  • ATG induction did not influence the risk of graft loss from HCV-related disease (P=.75).
  • When only HCV-related graft loss was considered, 10-year graft survival for HCV-positive recipients was 74% (ATG induction) versus 68.2% (no ATG induction).
  • [MeSH-minor] Adult. Aged. Alcohol Drinking. Cadaver. Cause of Death. Cytomegalovirus Infections / complications. Female. Follow-Up Studies. Graft Rejection / etiology. Graft Survival. Hepatitis B / complications. Humans. Male. Middle Aged. Recurrence. Risk Factors. Survival Rate. Treatment Outcome

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  • (PMID = 16137581.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antilymphocyte Serum; 0 / Immunosuppressive Agents
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73. Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Bencko V, Moullan N, Chabrier A, Hung R, Hall J, Canzian F, Brennan P: Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev; 2006 Apr;15(4):696-703
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  • [Title] Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.
  • This increase is likely to be due to patterns of alcohol and tobacco consumption.
  • We analyzed six SNPs in three genes related to ethanol metabolism: alcohol dehydrogenase 1B and 1C (ADH1B, ADH1C) and aldehyde dehydrogenase 2 (ALDH2).
  • When results were analyzed by subsite, strong main effects were observed for squamous cell carcinoma of the esophagus for all six variants.
  • Among carriers who drank alcohol at least thrice to four times a week, the AF(c) for having at least one ALDH2 variant was 49% (21.3-66.8%) for all upper aerodigestive tract cancers, increasing to 68.9% (42.9-83.1%) for esophageal cancer.
  • CONCLUSIONS: Polymorphisms in the ADH1B and ALDH2 genes are associated with upper aerodigestive tract cancer in Central European populations and interact substantially with alcohol consumption.
  • [MeSH-major] Alcohol Dehydrogenase / genetics. Aldehyde Dehydrogenase / genetics. Head and Neck Neoplasms / epidemiology. Head and Neck Neoplasms / etiology

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  • (PMID = 16614111.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA92039
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 1.1.1.1 / ADH1C protein, human; EC 1.1.1.1 / Alcohol Dehydrogenase; EC 1.2.1.3 / ALDH2 protein, human; EC 1.2.1.3 / Aldehyde Dehydrogenase
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74. Wursthorn K, Manns MP, Wedemeyer H: Natural history: the importance of viral load, liver damage and HCC. Best Pract Res Clin Gastroenterol; 2008;22(6):1063-79
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  • Chronic hepatitis B and hepatitis C virus infections are the major causes of liver disease, hepatocellular carcinoma (HCC) and liver-related mortality worldwide.
  • Among factors known to influence the natural history of viral hepatitis are age at the time of infection, duration of infection, serum alanine aminotransferase (ALT) levels, male sex, alcohol consumption, and coinfections.
  • [MeSH-major] Carcinoma, Hepatocellular / epidemiology. Hepatitis B, Chronic / epidemiology. Hepatitis C, Chronic / epidemiology. Liver Neoplasms / epidemiology
  • [MeSH-minor] Age Factors. Alanine Transaminase / blood. Alcohol Drinking / epidemiology. Causality. Comorbidity. Disease Progression. Fatty Liver / blood. Fatty Liver / epidemiology. HIV Infections / epidemiology. Humans. Insulin Resistance. Liver Cirrhosis / blood. Liver Cirrhosis / epidemiology. Predictive Value of Tests. Risk Factors. Sex Factors. Smoking / epidemiology. Viral Load

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  • (PMID = 19187867.001).
  • [ISSN] 1532-1916
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] EC 2.6.1.2 / Alanine Transaminase
  • [Number-of-references] 116
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75. Hafkamp HC, Manni JJ, Haesevoets A, Voogd AC, Schepers M, Bot FJ, Hopman AH, Ramaekers FC, Speel EJ: Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int J Cancer; 2008 Jun 15;122(12):2656-64
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  • The presence of HPV furthermore correlates significantly with low tobacco (p = 0.002) and alcohol intake (p = 0.011), poor differentiation grade (p = 0.019), small tumor size (p = 0.024), presence of a local metastasis (p = 0.001) and a decreased (loco)regional recurrence rate (p = 0.039).
  • These findings indicate that oncogenic processes in the tonsils of non-smokers differ from those occurring in smokers, the former being related to HPV 16 infection.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Papillomaviridae / isolation & purification. Smoking / adverse effects. Survival Rate. Tonsillar Neoplasms / virology

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18360824.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral
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76. Monteiro E, Varzim G, Silva R, da Costa B, Lopes C: Polymorphisms of the human OGG1 gene in laryngeal cancer: implications in radiotherapy response and survival. Rev Laryngol Otol Rhinol (Bord); 2005;126(3):135-40
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  • Ser326Cys polymorphism in the hOGG1 gene is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, and appears to be related to susceptibility to certain smoking and alcohol-related orolaryngeal cancers.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / radiotherapy. DNA Glycosylases / genetics. Laryngeal Neoplasms / genetics. Laryngeal Neoplasms / radiotherapy. Polymorphism, Genetic

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  • (PMID = 16366378.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases; EC 3.2.2.- / oxoguanine glycosylase 1, human
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77. Binkley N: A perspective on male osteoporosis. Best Pract Res Clin Rheumatol; 2009 Dec;23(6):755-68
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  • The incidence of osteoporosis-related fracture is similar to myocardial infarction and exceeds that of lung and prostate carcinoma combined.
  • A decline in sex steroids and glucocorticoid and alcohol use, among other factors, contribute to bone loss and fracture risk.


78. Ferenci P, Ferenci S, Datz C, Rezman I, Oberaigner W, Strauss R: Morbidity and mortality in paid Austrian plasma donors infected with hepatitis C at plasma donation in the 1970s. J Hepatol; 2007 Jul;47(1):31-6
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  • Thirty-four percent of plasma donors had advanced liver disease; alcohol abuse and diabetes were related to progression.
  • Twenty-one patients developed hepatocellular carcinoma; 36 underwent liver transplantation.
  • Forty died, with death directly related to liver disease in 25 donors.

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  • [CommentIn] J Hepatol. 2007 Jul;47(1):4-6 [17512628.001]
  • (PMID = 17335929.001).
  • [ISSN] 0168-8278
  • [Journal-full-title] Journal of hepatology
  • [ISO-abbreviation] J. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents
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79. Fracanzani AL, Piperno A, Valenti L, Fraquelli M, Coletti S, Maraschi A, Consonni D, Coviello E, Conte D, Fargion S: Hemochromatosis in Italy in the last 30 years: role of genetic and acquired factors. Hepatology; 2010 Feb;51(2):501-10
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  • A cohort of 452 Italian patients with iron overload-338 HFE-related (C282Y homozygotes or compound C82Y/H63D heterozygotes) and 114 non-HFE-related-were followed prospectively for a median of 112 months.
  • Alcohol intake, smoking habits, and iron removed to depletion were similar in patients with and without HFE-related iron overload.
  • Hepatitis B virus (4% and 9%; P = 0.04) and hepatitis C virus (6% and 19%; P = 0.002) infections were more frequent in patients with non-HFE-related iron overload.
  • Seventy-three percent of patients with HFE and 61% of patients with non-HFE-related disease had no acquired risk factor.
  • Sex, alcohol intake, prevalence of smoking, hepatitis C virus infection, glucose, lipids, iron-related parameters, and prevalence of C282Y/H63D differed significantly over the years.
  • Survival did not differ across the decades in cirrhotic patients; hepatocellular carcinoma occurred similarly in HFE and non-HFE patients.
  • CONCLUSION: Patients with HFE and non-HFE-related iron overload have comparable iron overload and similar clinical history.

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  • [CommentIn] Hepatology. 2010 Apr;51(4):1473-4; author reply 1474 [20373380.001]
  • (PMID = 20101754.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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80. Toshikuni N, Izumi A, Nishino K, Inada N, Sakanoue R, Yamato R, Suehiro M, Kawanaka M, Yamada G: Comparison of outcomes between patients with alcoholic cirrhosis and those with hepatitis C virus-related cirrhosis. J Gastroenterol Hepatol; 2009 Jul;24(7):1276-83
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  • [Title] Comparison of outcomes between patients with alcoholic cirrhosis and those with hepatitis C virus-related cirrhosis.
  • The cumulative rates of hepatocellular carcinoma (HCC) development were significantly lower in the alcoholic patients than in the HCV-infected patients (6.8% vs 50.3% at 10 years, P = 0.0003), while the cumulative rates of hepatic decompensation (37.4% vs 51.7% at 10 years) and survival (53.8% vs 47.4% at 10 years) did not significantly differ between the two groups (Kaplan-Meir analysis).
  • Multivariate analyses using the Cox proportional hazard model revealed that the risk of HCC was lower in alcoholic cirrhosis than in HCV-related cirrhosis (hazard ratio (HR), 0.46), while the risk of hepatic decompensation and mortality was the same.
  • CONCLUSIONS: Survival of patients with alcoholic cirrhosis was similar to that of patients with HCV-related cirrhosis.
  • The risk of HCC development was lower in alcoholic cirrhosis than in HCV-related cirrhosis.
  • Abstinence from alcohol was important for improving the survival of patients with alcoholic cirrhosis.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Hepatitis C / complications. Liver Cirrhosis / virology. Liver Cirrhosis, Alcoholic / complications. Liver Failure / etiology. Liver Neoplasms / etiology

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  • (PMID = 19486451.001).
  • [ISSN] 1440-1746
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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81. Bravi F, Bosetti C, Scotti L, Talamini R, Montella M, Ramazzotti V, Negri E, Franceschi S, La Vecchia C: Food groups and renal cell carcinoma: a case-control study from Italy. Int J Cancer; 2007 Feb 1;120(3):681-5
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  • [Title] Food groups and renal cell carcinoma: a case-control study from Italy.
  • Although nutrition and diet have been related to renal cell carcinoma (RCC), the role of specific foods or nutrients on this cancer is still controversial.
  • We evaluated the relation between a wide range of foods and the risk of RCC in an Italian case-control study including 767 patients (494 men and 273 women) younger than 79 years with incident, histologically confirmed RCC, and 1,534 controls (988 men and 546 women) admitted to the same hospitals as cases for a wide spectrum of acute, non-neoplastic conditions, not related to long term diet modifications.
  • A validated and reproducible food frequency questionnaire, including 78 foods and beverages, plus a separate section on alcohol drinking, was used to assess patients' dietary habits 2 years before diagnosis or hospital admission.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Carcinoma, Renal Cell / physiopathology. Energy Intake / physiology. Food. Kidney Neoplasms / pathology
  • [MeSH-minor] Aged. Alcohol Drinking. Body Mass Index. Case-Control Studies. Diet. Educational Status. Female. Humans. Italy. Male. Middle Aged. Multivariate Analysis. Odds Ratio. Risk Factors. Smoking

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  • [CommentIn] Int J Cancer. 2007 Nov 1;121(9):2116-7 [17640056.001]
  • (PMID = 17058282.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Brechot C, Kremsdorf D, Soussan P, Pineau P, Dejean A, Paterlini-Brechot P, Tiollais P: Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms. Pathol Biol (Paris); 2010 Aug;58(4):278-87
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  • [Title] Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms.
  • Chronic hepatitis B (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC).
  • This review will summarise the current knowledge on the mechanisms involved in HBV-related liver carcinogenesis.
  • It will show in particular how viruses can be viewed as tools to discover and dissect new cellular pathways involved in cancer development and emphasize the potential synergistic effects between HBV and hepatitis C virus (HCV), as well as between viral infections and other environmental factors, such as alcohol.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Carcinoma, Hepatocellular / virology. Hepatitis B, Chronic / complications. Liver Neoplasms / genetics. Liver Neoplasms / virology

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  • [Copyright] Copyright 2010. Published by Elsevier SAS.
  • (PMID = 20667665.001).
  • [ISSN] 1768-3114
  • [Journal-full-title] Pathologie-biologie
  • [ISO-abbreviation] Pathol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / Hepatitis B Surface Antigens; 0 / Trans-Activators; 0 / hepatitis B virus X protein
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83. Yenugadhati N, Birkett NJ, Momoli F, Krewski D: Occupations and lung cancer: a population-based case-control study in British Columbia. J Toxicol Environ Health A; 2009;72(10):658-75
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  • Occupational associations for 2998 lung cancer cases, including histological subtypes, were assessed by logistic regression using other cancer cases, excluding smoking-related cancers, as controls.
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adult. Age of Onset. Aged. Alcohol Drinking / epidemiology. British Columbia / epidemiology. Carcinoma, Large Cell / epidemiology. Carcinoma, Squamous Cell / epidemiology. Case-Control Studies. Data Interpretation, Statistical. Education. Ethnic Groups. Humans. Male. Metallurgy. Middle Aged. Population. Small Cell Lung Carcinoma / epidemiology. Smoking / epidemiology. Young Adult

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  • (PMID = 19308851.001).
  • [ISSN] 1528-7394
  • [Journal-full-title] Journal of toxicology and environmental health. Part A
  • [ISO-abbreviation] J. Toxicol. Environ. Health Part A
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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84. Pekow JR, Bhan AK, Zheng H, Chung RT: Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. Cancer; 2007 Jun 15;109(12):2490-6
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  • [Title] Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis.
  • Previous studies have suggested that hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with hepatitis C virus (HCV) infection.
  • The authors sought to determine whether hepatic steatosis is associated with hepatocellular carcinoma (HCC) in a cohort of patients with hepatitis C-related cirrhosis.
  • Steatosis, age, sex, body mass index, HCV RNA, HCV genotype, Model for End-Stage Liver Disease (MELD) score, chronic alcohol use, and diabetes were examined in univariate and multivariate analyses for association with HCC.
  • CONCLUSIONS: In patients with HCV-related cirrhosis, the presence of hepatic steatosis is independently associated with the development of hepatocellular carcinoma.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Fatty Liver / complications. Hepatitis C, Chronic / virology. Liver Cirrhosis / virology. Liver Neoplasms / etiology


85. Lengyel G, Fehér J: [Combined interferon, ribavirin treatment and the occurrence of hepatocellular carcinoma]. Orv Hetil; 2010 Jul 18;151(29):1177-81
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  • [Title] [Combined interferon, ribavirin treatment and the occurrence of hepatocellular carcinoma].
  • [Transliterated title] Kombinált interferon-ribavirin kezelés és a hepatocellularis carcinoma elofordulása.
  • Hepatocellular carcinoma (HCC) is the sixth most common cause of cancer-related death worldwide.
  • Primary hepatocellular carcinoma can be found most frequently (80-90%) in patients with liver cirrhosis.
  • The most frequent causes of liver cirrhosis are chronic hepatitis B and C virus infections and chronic alcohol consumption.
  • [MeSH-major] Antiviral Agents / therapeutic use. Carcinoma, Hepatocellular / prevention & control. Hepatitis B, Chronic / drug therapy. Hepatitis C, Chronic / drug therapy. Interferons / therapeutic use. Liver Neoplasms / prevention & control. Ribavirin / therapeutic use

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  • (PMID = 20591786.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antiviral Agents; 49717AWG6K / Ribavirin; 9008-11-1 / Interferons
  • [Number-of-references] 25
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86. Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E: S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology; 2009 Aug;50(2):462-71
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  • [Title] S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.
  • Hepatocellular carcinoma (HCC) remains a common cancer worldwide that lacks effective chemoprevention or treatment.
  • SAMe's chemopreventive effect may be related to its proapoptotic action and its ability to inhibit angiogenesis.

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  • (PMID = 19444874.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / T32 AA007578; None / None / / R01 DK051719-12; United States / NIAAA NIH HHS / AA / P50AA11999; United States / NCCIH NIH HHS / AT / R01 AT001576; United States / NIDDK NIH HHS / DK / R01 DK051719; United States / NIDDK NIH HHS / DK / R01 DK051719-12; United States / NCCIH NIH HHS / AT / AT1576; United States / NCCIH NIH HHS / AT / R21 AT002311; United States / NCCIH NIH HHS / AT / AT002311; United States / NIAAA NIH HHS / AA / T32AA07578; United States / NIDDK NIH HHS / DK / DK51719; United States / NIDDK NIH HHS / DK / P30DK48522; United States / NIDDK NIH HHS / DK / P30 DK048522; United States / NIAAA NIH HHS / AA / P50 AA011999
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 7LP2MPO46S / S-Adenosylmethionine
  • [Other-IDs] NLM/ NIHMS117036; NLM/ PMC2754739
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87. Nair S, Pillai MR: Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers. Oral Dis; 2005 Nov;11(6):350-9
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  • Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy and is a major cause of cancer morbidity and mortality worldwide.
  • Carcinoma of the uterine cervix is the most common female malignancy in the world.
  • While cervical cancer is a worldwide disease, oral cancer has the highest incidence in developing countries, especially among tobacco and alcohol users and betel quid chewers.
  • More than 40 variants have been classified and may be related to differences in progression of squamous intraepithelial lesions.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Mouth Neoplasms / virology. Papillomaviridae / genetics. Papillomavirus Infections / virology. Uterine Cervical Neoplasms / virology

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  • (PMID = 16269025.001).
  • [ISSN] 1354-523X
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / NF-kappa B; EC 1.5.1.20 / Methylenetetrahydrofolate Reductase (NADPH2)
  • [Number-of-references] 122
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88. Li FY, Lai MD: Colorectal cancer, one entity or three. J Zhejiang Univ Sci B; 2009 Mar;10(3):219-29
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  • For example, proximal colon cancer is usually related to the nucleotide instability pathway, as microsatellite instability (MSI).
  • Environmental factors such as diet and alcohol intake also differ in their role in the development of tumors in the three segments, proximal colon, distal colon, and rectum.
  • However, the dispute about the inconsistency of data concerning the site-specific mechanism of colorectal carcinoma does exist, and more evidence about molecular events of carcinogenesis and targeted therapy needs to be collected to definitely confirm the conception.

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  • (PMID = 19283877.001).
  • [ISSN] 1673-1581
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] China
  • [Number-of-references] 76
  • [Other-IDs] NLM/ PMC2650032
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89. Lagiou P, Georgila C, Minaki P, Ahrens W, Pohlabeln H, Benhamou S, Bouchardy C, Slamova A, Schejbalova M, Merletti F, Richiardi L, Kjaerheim K, Agudo A, Castellsague X, Macfarlane TV, Macfarlane GJ, Talamini R, Barzan L, Canova C, Simonato L, Lowry R, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy C, Nelis M, Metspalu A, Marron M, Hashibe M, Brennan PJ: Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection. Eur J Cancer Prev; 2009 Feb;18(1):76-84
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  • [Title] Alcohol-related cancers and genetic susceptibility in Europe: the ARCAGE project: study samples and data collection.
  • To address these issues, the International Agency for Research on Cancer initiated in 2002 the alcohol-related cancers and genetic susceptibility (ARCAGE) in Europe project, with the participation of 15 centers in 11 European countries.
  • A clear preponderance of smokers and alcohol drinkers among UADT cases compared with controls was observed.
  • [MeSH-major] Alcohol Drinking / adverse effects. Carcinoma, Squamous Cell / etiology. Genetic Predisposition to Disease. Head and Neck Neoplasms / etiology

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  • (PMID = 18830131.001).
  • [ISSN] 1473-5709
  • [Journal-full-title] European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
  • [ISO-abbreviation] Eur. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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90. Lin CS, Chang SC, Wang LS, Chou TY, Hsu WH, Wu YC, Wei YH: The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas. J Thorac Cardiovasc Surg; 2010 Jan;139(1):189-197.e4
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  • OBJECTIVE: The study objective was to evaluate the roles of mitochondrial DNA alterations in esophageal squamous cell carcinoma, with emphasis on the changes in the copy number and D310 variants of mitochondrial DNA.
  • METHODS: Paired samples microdissected from esophageal muscles, noncancerous esophageal mucosa, cancerous esophageal squamous cell carcinoma nests, and metastatic lymph nodes of 72 patients with esophageal squamous cell carcinoma were subjected to DNA extraction.
  • From noncancerous esophageal mucosa to cancerous esophageal squamous cell carcinoma nests and metastatic lymph nodes, the D310 variants were decreased from 2.2 to 1.7 and 1.5, respectively, with a trend to homoplasmy (P = .0009).
  • Among the 56 esophageal squamous cell carcinoma cancer nests with somatic D310 mutations, 51 (91.1%) had D310 variants in association with their corresponding noncancerous esophageal mucosa, including 36 (64.3%) fully related and 15 (26.8%) partially related pairs.
  • CONCLUSION: We demonstrated that somatic D310 mutations and increase in the copy number of mitochondrial DNA are of clinical importance in esophageal squamous cell carcinoma.
  • We also propose a model of DNA instability and clonal expansion during the carcinogenesis and progression of esophageal squamous cell carcinoma from the viewpoint of mitochondrial DNA transmission.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. DNA, Mitochondrial / genetics. Esophageal Neoplasms / genetics
  • [MeSH-minor] Alcohol Drinking / genetics. Base Sequence. DNA Copy Number Variations. Esophagus / chemistry. Female. Humans. Lymphatic Metastasis / genetics. Male. Middle Aged. Mucous Membrane / chemistry. Mutation. Prognosis. Smoking / genetics

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  • [Copyright] Copyright 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
  • (PMID = 19660406.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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91. Li CI, Daling JR, Malone KE, Bernstein L, Marchbanks PA, Liff JM, Strom BL, Simon MS, Press MF, McDonald JA, Ursin G, Burkman RT, Deapen D, Spirtas R: Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer. Cancer Epidemiol Biomarkers Prev; 2006 May;15(5):946-54
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  • METHODS: Information on family history of cancer and reproductive, hormonal, anthropometric, and lifestyle characteristics were collected in a multicenter population-based case-control study consisting of 3,463 ductal, 274 lobular, 261 ductal-lobular, 91 medullary, 77 tubular, 70 comedo, and 61 mucinous invasive breast carcinoma cases (ages 35-64 years, newly diagnosed 1994-1998) and 4,682 controls.
  • RESULTS: Heterogeneity in the risks of different histologic types of breast cancer was observed for three exposures: menopausal hormone use, body mass index (BMI), and alcohol consumption.
  • Specifically, current use of unopposed estrogen was associated with a reduced risk of ductal carcinoma and increased risk of comedocarcinoma, and current use of estrogen and progestin was associated with elevated risks of ductal-lobular and tubular carcinomas.
  • Among postmenopausal women, BMI was only inversely related to risk of ductal-lobular carcinoma, and alcohol use was only positively related to risk of lobular carcinoma.
  • [MeSH-minor] Adenocarcinoma, Mucinous / epidemiology. Adenocarcinoma, Mucinous / pathology. Adult. Alcohol Drinking / epidemiology. Body Mass Index. Carcinoma, Ductal, Breast / epidemiology. Carcinoma, Ductal, Breast / pathology. Carcinoma, Lobular / epidemiology. Carcinoma, Lobular / pathology. Case-Control Studies. Estrogen Replacement Therapy. Female. Humans. Middle Aged. Neoplasm Invasiveness. Regression Analysis. Risk Factors. United States / epidemiology

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  • (PMID = 16702375.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / N01-HD-2-3166; United States / NICHD NIH HHS / HD / N01-HD-2-3168; United States / NICHD NIH HHS / HD / N01-HD-3-3174; United States / NICHD NIH HHS / HD / N01-HD-3-3175; United States / NICHD NIH HHS / HD / N01-HD-3-3176; United States / NICHD NIH HHS / HD / Y01-HD-7022
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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92. Ladero JM, Martínez C, García-Martín E, Ropero P, Briceño O, Villegas A, Díaz-Rubio M, Agúndez JA: Glutathione S-transferase M1 and T1 genetic polymorphisms are not related to the risk of hepatocellular carcinoma: a study in the Spanish population. Eur J Cancer; 2006 Jan;42(1):73-7
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  • [Title] Glutathione S-transferase M1 and T1 genetic polymorphisms are not related to the risk of hepatocellular carcinoma: a study in the Spanish population.
  • Glutathione S-transferases constitute a superfamily of enzymes that catalyse the inactivating conjugation of endogenous and environmental substrates involved in the pathogenesis of hepatocellular carcinoma (HCC) and glutathione.
  • Gender, age at diagnosis, tobacco use, chronic infection with hepatitis B or C virus and alcohol abuse did not influence these results.
  • In conclusion, polymorphisms in GSTM1 and GSTT1 genes are not related to the incidence of HCC in a high-risk Spanish population.
  • [MeSH-major] Carcinoma, Hepatocellular / genetics. Glutathione Transferase / genetics. Liver Neoplasms / genetics. Polymorphism, Genetic / genetics

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  • (PMID = 16314088.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.5.1.- / glutathione S-transferase T1; EC 2.5.1.18 / Glutathione Transferase; EC 2.5.1.18 / glutathione S-transferase M1
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93. Gomaa AI, Khan SA, Toledano MB, Waked I, Taylor-Robinson SD: Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol; 2008 Jul 21;14(27):4300-8
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  • [Title] Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis.
  • Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world.
  • Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future.
  • This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance.

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  • (PMID = 18666317.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] ENG
  • [Grant] United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aflatoxins
  • [Number-of-references] 134
  • [Other-IDs] NLM/ PMC2731180
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94. de Vicente JC, Fresno MF, Villalain L, Vega JA, Hernández Vallejo G: Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma. Oral Oncol; 2005 Mar;41(3):283-93
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  • [Title] Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma.
  • To successfully establish a metastasis from an invasive carcinoma, the first step involves the degradation of the underlying basement membrane, which is mainly made up of type IV collagen.
  • MMP-2 immunoreactivity was significantly higher in patients with alcohol consumption (p = 0.028) (OR = 4), and in those younger than 60 years (p = 0.041).
  • MMP-9 immunostaining showed statistically significant association with the tumor grade of differentiation (p = 0.019), the T-stage (p = 0.05), and also with the alcohol intake (p = 0.04) (OR = 7.67).
  • In patients without regional lymph node metastasis, positive MMP-9 immunostaining was related to poor survival rates (p = 0.02; OR = 5.8).
  • MMP-2 and -9 are involved in the invasion process of oral cancer, and MMP-9 is related to poor prognosis in the subset of patients without neck node metastasis.
  • [MeSH-major] Carcinoma, Squamous Cell / enzymology. Matrix Metalloproteinase 2 / analysis. Mouth Neoplasms / enzymology. Neoplasm Proteins / analysis
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Alcohol Drinking / adverse effects. Basement Membrane / metabolism. Collagen Type IV / metabolism. Female. Humans. Immunohistochemistry / methods. Lymphatic Metastasis. Male. Matrix Metalloproteinase 9 / analysis. Matrix Metalloproteinase 9 / metabolism. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 15743691.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Collagen Type IV; 0 / Neoplasm Proteins; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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95. Alberti A, Vario A, Ferrari A, Pistis R: Review article: chronic hepatitis C--natural history and cofactors. Aliment Pharmacol Ther; 2005 Nov;22 Suppl 2:74-8
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  • This heterogeneity is largely related to host factors that have been clearly proven to affect the severity and rapidity of disease progression.
  • The most relevant factors that have been shown to accelerate progression to cirrhosis include age at infection, alcohol abuse and the metabolic syndrome with insulin resistance, obesity and hepatic steatosis.
  • Co-infection with HIV and/or HBV also increases the risk of progression to cirrhosis and to hepatocellular carcinoma.
  • Surprisingly enough, viral related factors appear as less important and neither the virus genotype and load have been found to exert a clear influence on disease severity and progression, although more data in this field, and particularly on the role of different viral proteins in causing cytopathic effects, are awaited and may change this view in the near future.

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  • (PMID = 16225479.001).
  • [ISSN] 0269-2813
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 29
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96. Pissaia A Jr, Bernard D, Scatton O, Soubrane O, Conti F, Calmus Y: Significance of serum tumor markers carcinoembryonic antigen, CA 19-9, CA 125, and CA 15-3 in pre-orthotopic liver transplantation evaluation. Transplant Proc; 2009 Mar;41(2):682-4
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  • CA 125 was also elevated among patients with ascites, esophageal varices, or alcohol-related cirrhosis.
  • CA 15-3 levels were also increased among patients with elevated alkaline phosphatase, while elevated CEA was related to ascites, bilirubin, and prothrombin time (PT) levels, as well as alcohol-related cirrhosis.
  • There was no association between hepatocellular carcinoma and tumor markers.

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  • (PMID = 19328956.001).
  • [ISSN] 0041-1345
  • [Journal-full-title] Transplantation proceedings
  • [ISO-abbreviation] Transplant. Proc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CA-125 Antigen; 0 / CA-19-9 Antigen; 0 / Carcinoembryonic Antigen; 0 / Mucin-1
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97. Miki D, Aikata H, Uka K, Saneto H, Kawaoka T, Azakami T, Takaki S, Jeong SC, Imamura M, Kawakami Y, Takahashi S, Itamoto T, Asahara T, Arihiro K, Chayama K: Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma. J Gastroenterol; 2008;43(7):550-7
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  • [Title] Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma.
  • BACKGROUND: It is well known that the incidence of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) correlates with progression of liver fibrosis.
  • The aim of this study was to elucidate the clinicopathological features of elderly patients with HCV-related HCC.
  • Next, we selected pure HCV-related HCC patients by excluding the patients with other probable factors for hepatocarcinogenesis (anti-HBc, interferon therapy, and alcohol) and compared the two groups again.
  • RESULTS: Higher platelet count, lower male/female ratio, lower rate of habitual alcohol consumption, and better Child-Pugh class were recognized in the elderly group thant the younger group, statistically.
  • After selection of pure HCV-related HCC patients, in a stepwise multi variate analysis, male sex and platelet count <10 x 10(4)/mm3 were significant variables associated with age <70.
  • In addition to fibrosis, aging could be a factor affecting HCV-related hepatocarcinogenesis.
  • [MeSH-major] Carcinoma, Hepatocellular / virology. Hepatitis C, Chronic / complications. Liver Neoplasms / virology

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  • [Journal-full-title] Journal of gastroenterology
  • [ISO-abbreviation] J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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98. Papadas TA, Alexopoulos EC, Mallis A, Jelastopulu E, Mastronikolis NS, Goumas P: Survival after laryngectomy: a review of 133 patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol; 2010 Jul;267(7):1095-101
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Survival after laryngectomy: a review of 133 patients with laryngeal carcinoma.
  • Except 3, all were smokers and 56 (41%) heavy alcohol users.
  • Results showed that 64 (48.1%) patients died during the follow-up, 58 (43.6%) of them died from cause related to their disease.
  • Significant prognostic factors for OS included patient age, advanced staging, heavy alcohol use and poor tumor differentiation while for DFS affected mainly by poor tumor differentiation.
  • We conclude that the disease stage at presentation, tumor grade and alcohol consumption prove to be important predictors for the OS as well as the DFS in our series.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Alcohol Drinking / adverse effects. Combined Modality Therapy. Female. Greece / epidemiology. Humans. Male. Middle Aged. Neoplasm Staging. Occupations. Proportional Hazards Models. Risk Factors. Smoking / adverse effects. Survival Analysis. Treatment Outcome

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  • (PMID = 19921233.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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99. Beyazit Y, Kekilli M, Purnak T, Kurt M: Possible role of adipocytokines in the development of nonalcoholic steatohepatitis-related hepatocellular carcinoma. Hepatology; 2010 Sep;52(3):1172
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Possible role of adipocytokines in the development of nonalcoholic steatohepatitis-related hepatocellular carcinoma.
  • [MeSH-major] Adipokines / physiology. Carcinoma, Hepatocellular / physiopathology. Fatty Liver / physiopathology. Liver Neoplasms / physiopathology
  • [MeSH-minor] Alcohol Drinking. Humans. Risk Factors

  • MedlinePlus Health Information. consumer health - Liver Cancer.
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  • [CommentOn] Hepatology. 2010 Jun;51(6):1972-8 [20209604.001]
  • (PMID = 20683933.001).
  • [ISSN] 1527-3350
  • [Journal-full-title] Hepatology (Baltimore, Md.)
  • [ISO-abbreviation] Hepatology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adipokines
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100. McGlynn KA, London WT: Epidemiology and natural history of hepatocellular carcinoma. Best Pract Res Clin Gastroenterol; 2005 Feb;19(1):3-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology and natural history of hepatocellular carcinoma.
  • Hepatocellular carcinoma (HCC) is a major contributor to cancer incidence and mortality.
  • In contrast, hepatitis C virus and alcohol consumption are more important risk factors in low-risk countries.
  • Reasons for both trends are not completely understood, but are likely related to public health efforts in Asia and the increase in hepatitis C virus infection in low-risk countries.
  • [MeSH-major] Carcinoma, Hepatocellular / epidemiology. Global Health. Liver Neoplasms / epidemiology
  • [MeSH-minor] Aflatoxins / adverse effects. Alcohol Drinking. Chemoprevention. Food Contamination. Genetic Predisposition to Disease. Hepatitis B / complications. Hepatitis C / complications. Humans. Incidence. Liver Cirrhosis / complications. Risk Factors

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  • (PMID = 15757802.001).
  • [ISSN] 1521-6918
  • [Journal-full-title] Best practice & research. Clinical gastroenterology
  • [ISO-abbreviation] Best Pract Res Clin Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aflatoxins
  • [Number-of-references] 130
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