[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 799
1. Wong AK, Chan RC, Aggarwal N, Singh MK, Nichols WS, Bose S: Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies. Mod Pathol; 2010 Jan;23(1):144-50
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies.
  • Human papillomavirus (HPV) infection strongly correlates with the development of anal intraepithelial neoplasias and carcinomas; however, few studies have characterized the distribution of the specific subtypes of the virus in the varying grades of dysplasia.
  • This report characterizes the distribution of HPV 16/18 in surgical specimens with anal intraepithelial neoplasia (AIN) I-III and histological variants of anal carcinoma.
  • A total of 111 anal surgical specimens with no dysplasia (10), AIN I-III (53), and anal carcinomas (48) were evaluated for the presence of high-risk HPV infection and subtyped by nested PCR or the Invader Assay.
  • High-risk virus types were detected in progressively greater number of anal intraepithelial lesions from 56% in low grade to 88% in high grade.
  • Most (89%) squamous carcinomas were associated with high-risk viruses, 68% with type 16, a prevalence similar to that noted in high-grade dysplasia.
  • Non-16/18 subtypes were encountered more frequently in squamous carcinomas from immunodeficient individuals (57% cases) as compared with immunocompetent individuals (18% cases).
  • The similarity in the prevalence of type 16 in high-grade dysplasia and squamous carcinomas suggests that anal intraepithelial lesion III is the true precursor of squamous carcinoma and warrants aggressive management.
  • Anal intraepithelial lesions II showed a virus distribution that was similar to low-grade dysplasia.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. Papillomavirus Infections / virology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19838162.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  •  go-up   go-down


2. Walts AE, Lechago J, Hu B, Shwayder M, Sandweiss L, Bose S: P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN). Clin Med Pathol; 2008;1:7-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN).
  • BACKGROUND: Significant variation is reported in the diagnosis of HPV-associated AIN.
  • We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN.
  • This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN.
  • DESIGN: H&E stained slides of 60 anal biopsies were reviewed by three pathologists and consensus diagnoses were achieved: 25 negative, 12 low (condyloma and/or AIN I) and 23 high (9 AIN II and 14 AIN III) grade lesions.
  • RESULTS: Addition of p16 and Ki67 immunostains reduced intra- and interobserver variability, improved concurrence with consensus diagnoses and reduced two-step differences in diagnosis.
  • Negative and high grade AIN diagnoses showed the most improvement in concurrence levels.
  • CONCLUSION: Addition of p16 and Ki67 immunostains is helpful in the diagnosis and grading of AIN.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Semin Oncol. 2000 Aug;27(4):471-9 [10950374.001]
  • [Cites] JAMA. 1982 Apr 9;247(14):1988-90 [7062503.001]
  • [Cites] JAMA. 2002 Apr 24;287(16):2114-9 [11966386.001]
  • [Cites] Bull Cancer. 2003 May;90(5):405-11 [12850763.001]
  • [Cites] Cancer. 2004 Jul 15;101(2):270-80 [15241823.001]
  • [Cites] Cancer. 2005 Apr 1;103(7):1447-56 [15726546.001]
  • [Cites] Obstet Gynecol. 1990 Jan;75(1):131-3 [2296409.001]
  • [Cites] J Clin Pathol. 1994 Nov;47(11):1032-4 [7829679.001]
  • [Cites] Lancet. 1998 Jun 20;351(9119):1833-9 [9652666.001]
  • [Cites] Am J Pathol. 1998 Dec;153(6):1741-8 [9846965.001]
  • [Cites] Lancet. 1994 Mar 12;343(8898):636-9 [7906812.001]
  • [Cites] Dis Colon Rectum. 2003 Oct;46(10):1332-6; discussion 1336-8 [14530670.001]
  • [Cites] Am J Surg Pathol. 2006 Jul;30(7):795-801 [16819320.001]
  • [Cites] Gastroenterol Clin North Am. 2007 Dec;36(4):969-87, ix [17996800.001]
  • [Cites] Acta Pathol Microbiol Immunol Scand A. 1986 Sep;94(5):343-9 [3766143.001]
  • [Cites] Clin Obstet Gynecol. 1967 Dec;10(4):748-84 [4172733.001]
  • [Cites] J Acquir Immune Defic Syndr. 2001 Dec 15;28(5):422-8 [11744829.001]
  • (PMID = 21876646.001).
  • [ISSN] 1178-1181
  • [Journal-full-title] Clinical medicine. Pathology
  • [ISO-abbreviation] Clin Med Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3159996
  • [Keywords] NOTNLM ; Ki67 / P16 / anal intraepithelial neoplasia (AIN) / condyloma / human papilloma virus (HPV) / interobserver variability / intraobserver variability
  •  go-up   go-down


3. Lytwyn A, Salit IE, Raboud J, Chapman W, Darragh T, Winkler B, Tinmouth J, Mahony JB, Sano M: Interobserver agreement in the interpretation of anal intraepithelial neoplasia. Cancer; 2005 Apr 1;103(7):1447-56
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interobserver agreement in the interpretation of anal intraepithelial neoplasia.
  • BACKGROUND: Anal carcinoma incidence is increasing, and is highest among men with human immunodeficiency virus (HIV) infection who have sex with men.
  • Anal carcinoma and anal intraepithelial neoplasia (AIN) are ascertained on tissue histology, but requires invasive procedures.
  • Screening for AIN using anal cytology was suggested.
  • The authors evaluated agreement on cytologic and biopsy specimens from HIV-positive men undergoing anal carcinoma screening.
  • METHODS: One hundred twenty-nine HIV-positive men with a history of anal-receptive intercourse underwent anal cytology, anoscopy, and biopsy.
  • Reliability for the Bethesda classification system was at least moderate, except for the cytologic category of atypical squamous cells of undetermined significance (kappa = 0.12).
  • Fourteen of 29 (48.3%) cytology specimens and 36 of 47 (76.6%) biopsy specimens with consensus interpretation of high-grade squamous intraepithelial lesions (HSIL) were interpreted originally as HSIL by > or = 3 pathologists.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Observer Variation

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2005 American Cancer Society.
  • (PMID = 15726546.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


Advertisement
4. Kreuter A, Brockmeyer NH, Weissenborn SJ, Gambichler T, Stücker M, Altmeyer P, Pfister H, Wieland U, German Competence Network HIV/AIDS: Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia. J Invest Dermatol; 2008 Sep;128(9):2316-24
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia.
  • These patients have a strongly increased risk of HPV-induced anal cancer and its precursor lesion, anal intraepithelial neoplasia (AIN), and a moderately increased risk for penile cancer.
  • Only limited data exist on penile intraepithelial neoplasia (PIN) in HIV+MSM.
  • We determined the prevalence and evaluated the virologic characteristics of PIN and AIN in 263 HIV+MSM.
  • In case of histologically confirmed PIN (and AIN), HPV-typing, HPV-DNA load determination, and immunohistochemical staining for p16(INK4a) were performed.
  • PIN was detected in 11 (4.2%) and AIN in 156 (59.3%) patients.
  • Ten PIN patients also had AIN within the observation period.
  • Cutaneous beta-HPVs were found in PIN and AIN, but beta-HPV-DNA loads were very low, irrespective of the histological grade. p16(INK4a) Expression was detectable in all PIN lesions and correlated both with the histological grade and with high-risk HPV-DNA loads.
  • In view of the PIN prevalence found in our study, all HIV+MSM should be screened for PIN in addition to AIN screening.
  • [MeSH-major] Anus Diseases / epidemiology. Anus Neoplasms / epidemiology. Carcinoma in Situ / epidemiology. HIV Infections. Homosexuality, Male. Penile Neoplasms / epidemiology

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Anal Disorders.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18385760.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00365729
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  •  go-up   go-down


5. Wahl RU, Blazek C, Megahed M: [HPV type 16-associated anal intraepithelial neoplasia (AIN)]. Hautarzt; 2009 May;60(5):371-2
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [HPV type 16-associated anal intraepithelial neoplasia (AIN)].
  • [Transliterated title] HPV-Typ-16-assoziierte anale intraepitheliale Neoplasie (AIN).
  • A 25-year-old woman had suffered from a perianal ulcer for approximately 1 year.
  • Employing virologic and histologic techniques, we confirmed the diagnosis of an intraepithelial neoplasia.
  • Anal intraepithelial neoplasia (AIN) is induced by carcinogenic human papillomaviruses.
  • Because of its frequency, AIN is a crucial differential diagnosis for lesions of the anogenital area region failing to respond to standard therapies.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections / diagnosis. Papillomavirus Infections / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19430747.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


6. Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Stücker M, Altmeyer P, Swoboda J, Pfister H, Wieland U, German Competence Network HIV/AIDS: Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men. J Invest Dermatol; 2008 Aug;128(8):2078-83
Hazardous Substances Data Bank. Imiquimod .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men.
  • Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated precursor lesion of anal carcinoma, is highly prevalent in HIV-infected men having sex with men (MSM).
  • This prospective follow-up study evaluated the long-term results of imiquimod treatment of AIN in 19 HIV-infected MSM.
  • Standardized follow-up examinations included high-resolution anoscopy, anal cytology/histology, HPV typing, and DNA load determination for HPV types 16, 18, 31, and 33.
  • A total of 74% (14/19) of the patients remained free of AIN at the previously treated site.
  • Five patients (26%) had recurrent high-grade AIN after a mean time of 24.6 months.
  • During follow-up, 58% of all patients (11/19) developed new anal cytological abnormalities in previously normal, untreated anal regions.
  • 55% of these new AIN lesions were high-grade lesions and most of them were located intra-anally and associated with high-risk HPV types not detectable before therapy.
  • These results demonstrate that imiquimod leads to a high rate of long-term clearance of AIN in HIV-positive men together with a prolonged decrease of high-risk HPV-DNA load.
  • However, new AIN lesions associated with previously undetected HPV types frequently occur in untreated areas.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. DNA, Viral / drug effects. HIV Infections / complications. Papillomaviridae / genetics

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18273049.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / DNA, Viral; 99011-02-6 / imiquimod
  • [Investigator] Adam A; Schewe K; Weitner L; Aratesh K; Arendt G; Bartz C; Behrens G; Beichert M; Bieniek B; Cordes C; Bochow M; Brockmeyer N; Buchholz B; Bogner JR; Buhk T; Clad A; Dannecker M; Dupke S; von Einsiedel R; Esser S; Faetkenheuer G; Fischer K; Freiwald M; Friebe-Hoffmann U; Fenske S; Funk M; Ganschow R; Gingelmaier A; Glaunsinger T; Goebel FD; Gölz J; Grosch-Wörner I; Haberl A; Hamouda O; Harrer T; Hartmann M; Hartl H; Hölscher M; Hower M; Husstedt IW; Jansen K; Jäger H; Jessen H; Jessen A; Karwat M; Klausen G; Kirchhoff F; Knechten H; Köppe S; Kreuter A; Kuhlmann B; Langer P; Lauenroth-Mai; Lehmacher W; Lehmann M; Levin C; Lübke M; Maschke M; Marcus U; Mauss S; Meyerhans A; Meyer-Olson D; ter Meulen V; Michalik C; Moll A; Mosthaf FA; Mutz A; Neuen-Jacob E; Niehues T; Oette M; Paulus U; Plettenberg A; Potthoff A; Racz P; Racz K; Rasokat H; Rausch M; Reichelt D; Reitter A; Rieke A; Rockstroh J; Salzberger B; Schafberger A; Schauer J; Schlote F; Schmidt B; Schranz D; Scholten S; Schuler C; Schwab M; Schmidt W; Schmidt R; Schwarze S; Siffert W; Skaletz-Rorowski A; Sonnenberg-Schwan U; Sopper S; Spengler U; Staszewski S; Steffan E; Stellbrink HJ; Stoll M; Goecke T; Taubert S; Telschik A; Ulmer A; Ullrich R; Uberla K; Usadel S; Vogel M; Wagner R; Walter H; Warnatz K; Wasem J; Wiesel W; Von Weizsäcker K; Wieland U; Wintergerst U; Wolf E; Wolf H; Wünsche T; Wyen Ch; Zeitz M; Zylka-Menhorn V
  •  go-up   go-down


7. Parés D, Mullerat J, Pera M: [Anal intraepithelial neoplasia]. Med Clin (Barc); 2006 Nov 18;127(19):749-55
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia].
  • [Transliterated title] Neoplasia intraepitelial anal.
  • Human papillomavirus (HPV) is responsible for anal condylomata, anal intraepithelial neoplasia (AIN) and anal squamous cell carcinoma.
  • AIN is a premalignant condition that can progress to invasive carcinoma through different grades of severity of the disease called AIN I, AIN II and AIN III.
  • This paper looks at the current definition, diagnostic methods and management of AIN.
  • The incidence of AIN has increased significantly in the last decades.
  • The groups at risk are mainly patients with infection with human immunodeficiency virus, immunossuppressed patients and patients affected by HPV related diseases (e.g., cervical cancer or anal condyloma).
  • Accurate diagnosis of AIN lesions consists of accurate grading and disease extension.
  • Low grade AIN (AIN I) or in extensive lesions, follow-up is advised to determine the possible evolution to anal squamous cell carcinoma.
  • In cases of more severe and localized lesions (AIN II and AIN III), surgical resection should be considered if the predictive postoperative morbidity is low.
  • Screening programs for AIN are not currently in place and there might be much effort to study the management of HPV in these patients.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / surgery. Humans

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17198654.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 58
  •  go-up   go-down


8. Fox PA, Seet JE, Stebbing J, Francis N, Barton SE, Strauss S, Allen-Mersh TG, Gazzard BG, Bower M: The value of anal cytology and human papillomavirus typing in the detection of anal intraepithelial neoplasia: a review of cases from an anoscopy clinic. Sex Transm Infect; 2005 Apr;81(2):142-6
MedlinePlus Health Information. consumer health - Gay, Lesbian, Bisexual, and Transgender Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of anal cytology and human papillomavirus typing in the detection of anal intraepithelial neoplasia: a review of cases from an anoscopy clinic.
  • BACKGROUND: Previous studies have reached differing conclusions about the utility of anal cytology as a screening tool for anal intraepithelial neoplasia (AIN).
  • Comparison was made between results of anal cytology using the sampling method of Palefsky, and histological findings of biopsies taken from abnormal areas seen on high resolution anoscopic examination of the anal canal.
  • At screening of 34 asymptomatic men, 83% had anal cytological dysplasia and 78% had AIN.
  • CONCLUSION: Anal cytology by the Palefsky method is simple to undertake, has a sensitivity and specificity comparable with cervical cytology, and can therefore be used as the basis of a pilot screening project in centres with large cohorts of HIV positive homosexual men who have a high risk of developing anal carcinoma.
  • [MeSH-major] Anus Neoplasms / pathology. Bisexuality. Carcinoma in Situ / pathology. Homosexuality, Male. Papillomavirus Infections / pathology

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Eur J Cancer. 2000 Apr;36(6):754-8 [10762748.001]
  • [Cites] Dis Colon Rectum. 1999 Oct;42(10):1342-4 [10528776.001]
  • [Cites] Dis Colon Rectum. 2002 Apr;45(4):453-8 [12006924.001]
  • [Cites] Sex Transm Infect. 2002 Apr;78(2):135-8 [12081177.001]
  • [Cites] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259.001]
  • [Cites] Ann Intern Med. 2003 Mar 18;138(6):453-9 [12639077.001]
  • [Cites] JAMA. 1982 Apr 9;247(14):1988-90 [7062503.001]
  • [Cites] J Clin Pathol. 1986 Sep;39(9):933-44 [3760239.001]
  • [Cites] AIDS. 1993 Jan;7(1):43-9 [8382927.001]
  • [Cites] Genitourin Med. 1994 Feb;70(1):22-5 [8300094.001]
  • [Cites] AIDS. 1995 Nov;9(11):1255-62 [8561979.001]
  • [Cites] J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):415-22 [9170415.001]
  • [Cites] Dis Colon Rectum. 1997 Aug;40(8):919-28 [9269808.001]
  • [Cites] J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):320-6 [9525432.001]
  • [Cites] Lancet. 1998 Jun 20;351(9119):1833-9 [9652666.001]
  • [Cites] Cancer Res. 1999 Feb 1;59(3):753-7 [9973228.001]
  • [Cites] J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S42-8 [10430218.001]
  • [Cites] Sex Transm Infect. 1999 Jun;75(3):172-7 [10448395.001]
  • [Cites] J Virol Methods. 2000 Sep;89(1-2):29-37 [10996637.001]
  • (PMID = 15800092.001).
  • [ISSN] 1368-4973
  • [Journal-full-title] Sexually transmitted infections
  • [ISO-abbreviation] Sex Transm Infect
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1764665
  •  go-up   go-down


9. Bean SM, Meara RS, Vollmer RT, Conner MG, Crowe DR, Novak L, Eltoum IA, Robboy SJ, Chhieng DC: p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia. J Low Genit Tract Dis; 2009 Jul;13(3):145-53
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.
  • OBJECTIVES: Evaluation of anal intraepithelial neoplasia (AIN) is subjective.
  • Previous studies have shown p16 and Ki-67 expressions to correlate with AIN grade.
  • The objectives were (1) to determine the extent of interobserver agreement in evaluating AIN on routine hematoxylin and eosin (H&E) sections and (2) to test whether p16 and/or Ki-67 staining improve interobserver diagnostic agreement.
  • MATERIALS AND METHODS: Seventy-seven anal specimens were retrieved.
  • Diagnoses were normal/reactive, AIN I/HPV, AIN II, and AIN III.
  • Fair agreement was observed using H&E diagnosis alone (kappa = 0.38, S = 0.56).
  • CONCLUSIONS: Interobserver agreement for diagnosis of AIN was fair when based solely on H&E preparation. p16 alone improved interobserver agreement and demonstrated superior agreement when compared with H&E, Ki-67, and H&E/p16/Ki-67 combined.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. DNA, Neoplasm / analysis. Gene Expression Regulation, Neoplastic. Genes, p16 / physiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / analysis. Biopsy. Clinical Competence. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Observer Variation. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19550211.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA, Neoplasm
  •  go-up   go-down


10. Charúa-Guindic L, Esquivel-Ocampo EA, Villanueva-Herrero JA, Jiménez-Bobadilla B, Muñoz-Cortés SB, Leal-Tamez M, Avendaño-Espinosa O: [Anal intraepithelial neoplasia (NIA) and infection with human papillomavirus (HPV) in anoreceptive patients]. Rev Gastroenterol Mex; 2009;74(3):195-201
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia (NIA) and infection with human papillomavirus (HPV) in anoreceptive patients].
  • [Transliterated title] La neoplasia intraepitelial anal y la infección por virus del papiloma humano en pacientes anorreceptivos.
  • BACKGROUND: An association between human papilloma virus (HPV) infection and progression to anal intraepithelial neoplasia (AIN) and epidermoid cancer has been established.
  • OBJECTIVE: To know the prevalence of low and high grade AIN, as well as HPV infection in an anoreceptive patients group, infected or not, by human immunodeficiency virus (HIV).
  • Patients who accepted anal citology and high definition anoscopy and biopsies with a follow-up not minor of 3 months were included.
  • Anal cytology showed inflammatory alterations in 21 patients (28%), low grade intraepithelial lesion in 23 (52%); there were not patients with high grade epithelial lesion.
  • According to the high definition anoscopy, there were low grade intraepithelial lesion in 42 patients (95%) and high grade in 2 (5%).
  • Biopsy showed low grade intraepithelial in 26 patients (59%), high grade in 4 (9%) and inflammatory alterations in 14 (32%).
  • The prevalence of AIN and HPV infection was 68% in both diseases.
  • The HIV infection was associated with the presence of high grade AIN (p=0.002, OR 47.7) CONCLUSIONS: There is a high prevalence of AIN and HPV infection between patients with anoreceptive sexual relations.
  • The HIV infection is a risk factor for the development of high grade AIN.
  • [MeSH-major] Anus Neoplasms / complications. Carcinoma in Situ / complications. Papillomavirus Infections / complications. Sexual Behavior / statistics & numerical data
  • [MeSH-minor] Adolescent. Adult. Anal Canal / pathology. Biopsy. Disease Progression. Female. HIV Infections / complications. Humans. Male. Middle Aged. Risk Factors. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19858007.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
  •  go-up   go-down


11. Abbasakoor F, Boulos PB: Anal intraepithelial neoplasia. Br J Surg; 2005 Mar;92(3):277-90
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal intraepithelial neoplasia.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN) is believed to be a precursor of anal squamous cell cancer and its incidence is rising in high-risk groups, particularly those infected with the human immunodeficiency virus (HIV).
  • The natural history of AIN is unclear and management strategies are lacking.
  • METHODS: This review is based on a literature search (Medline and PubMed) with manual cross-referencing of all articles related to AIN.
  • RESULTS AND CONCLUSIONS: The aetiology of AIN is intricately linked with human papilloma viruses.
  • The pathological processes involved in the progression of AIN are becoming clearer but the natural history, particularly the rate of progression to invasive cancer, remains unknown.
  • There is no standard management for AIN and this is mainly due to difficulties in both diagnosis and treatment.
  • Long-term follow-up of these patients is essential until the natural history of AIN becomes clearer.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma in Situ. Carcinoma, Squamous Cell

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2005 British Journal of Surgery Society Ltd.
  • (PMID = 15736144.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 131
  •  go-up   go-down


12. Varnai AD, Bollmann M, Griefingholt H, Speich N, Schmitt C, Bollmann R, Decker D: HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis. Int J Colorectal Dis; 2006 Mar;21(2):135-42
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis.
  • BACKGROUND AND AIMS: Majority of cases of anal squamous cell carcinoma are human papilloma virus (HPV)-induced and result from anal intraepithelial neoplasia (AIN).
  • This study was conducted to examine methods which may enable the routine diagnosis of HPV-induced changes in the anal rim and the consequences of such detection especially in view of a more sensitive diagnosis of AIN.
  • METHODS: The study included biopsy samples from 87 patients who had been diagnosed with the following disease patterns: 47 invasive anal carcinoma, 33 AIN of varying severity and seven condylomatous lesions.
  • RESULTS: In 38 of 47 cases of anal carcinoma, HPV DNA could be detected via PCR (80.9%), the majority of which were HPV 16 (33/38=86.8%).
  • In 29 of the 33 cases of AIN, HPV DNA was detected (87.9%), most of these in AIN III (15/16=93.8%).
  • DISCUSSION: In our series, the clinical diagnosis of the invasive anal carcinoma had a high sensitivity of 93.6%, with a specificity of 80%.
  • In contrast, AIN had been detected clinically in none of the cases.
  • In this situation, especially with high-risk patients, our findings recommend anal HPV screening in combination with anal cytology and anoscopy.
  • CONCLUSION: Based on our results, we urgently recommend for any histological report on excision of anal lesions to include a statement whether histological markers of HPV infection were detected.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. DNA, Viral / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retrospective Studies

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Int J Colorectal Dis. 2007 Oct;22(10):1289 [16703315.001]
  • (PMID = 15864603.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Viral
  •  go-up   go-down


13. Kreuter A, Brockmeyer NH, Altmeyer P, Wieland U, German Competence Network HIV/AIDS: Anal intraepithelial neoplasia in HIV infection. J Dtsch Dermatol Ges; 2008 Nov;6(11):925-34
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal intraepithelial neoplasia in HIV infection.
  • In HIV-infected men who have sex with men (MSM), anal HPV prevalence is more than 90% and infections with multiple HPV types are common.
  • Anal intraepithelial neoplasia (AIN) is a potential precursor lesion of squamous cell carcinoma of the anus.
  • Like its cervical counterpart, cervical intraepithelial neoplasia (CIN), AIN is causally linked to persistent infections with high-risk HPV types such as HPV16 or HPV18.
  • As AIN and CIN share distinct biological similar-ities, AIN screenings analogous to Pap smear programs for CIN have been recommended in high-risk populations to reduce the incidence of anal carcinoma.
  • These screenings include cytological analysis followed by high resolution anoscopy in case of anal dysplasia.
  • Treatment guidelines for AIN are not yet available.
  • However, controlled studies on AIN treatment have not been performed.
  • The impact of HPV vaccination on AIN development will also need to be assessed.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / therapy. HIV Infections / diagnosis. HIV Infections / therapy. Papillomavirus Infections / diagnosis. Papillomavirus Infections / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18410393.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 46
  •  go-up   go-down


14. Scholefield JH, Castle MT, Watson NF: Malignant transformation of high-grade anal intraepithelial neoplasia. Br J Surg; 2005 Sep;92(9):1133-6
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of high-grade anal intraepithelial neoplasia.
  • BACKGROUND: The natural history of anal intraepithelial neoplasia (AIN) is uncertain.
  • METHODS: All patients were diagnosed with high-grade AIN (AIN III) between 1994 and 2003.
  • Diagnosis was by full-thickness biopsy and histopathological examination.
  • Excision of localized high-grade AIN was carried out in 28 patients with minimal morbidity.
  • Six patients were systemically immunosuppressed at diagnosis, all of whom had multifocal perianal lesions.
  • Three immunosuppressed patients developed invasive anal squamous carcinoma during follow-up.
  • By contrast, no invasive carcinomas were identified among immunocompetent patients with either localized or multifocal perianal disease.
  • CONCLUSION: AIN III appears to have a relatively low potential for malignant transformation in the immunocompetent patient.
  • However, immunosuppressed patients are more likely to have extensive AIN III and a greater risk of malignant change.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Cell Transformation, Neoplastic / pathology
  • [MeSH-minor] Adult. Carcinoma, Squamous Cell / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local. Prospective Studies

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2005 British Journal of Surgery Society Ltd.
  • (PMID = 16044425.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


15. Kreuter A, Brockmeyer NH, Hochdorfer B, Weissenborn SJ, Stücker M, Swoboda J, Altmeyer P, Pfister H, Wieland U: Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol; 2005 Apr;52(4):603-8
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN) represents a precursor lesion of invasive squamous cell carcinoma with a clear association to high-risk human papillomavirus (HPV) types.
  • HIV infection is strongly associated with a higher prevalence of genital HPV infection, a higher incidence of AIN, and, consecutively, an increased risk for anal cancer.
  • OBJECTIVE: The aim of this study was to determine the clinical spectrum of AIN and lesional HPV colonization in a cohort of homosexual men who were HIV positive and had a history of receptive anal intercourse.
  • RESULTS: Of all patients, 86% had anal HPV infection at their first visit.
  • AIN was diagnosed in 20 of the 103 patients (19.4%).
  • High-risk HPV types were present in all AIN cases with up to 7 different high-risk and up to 5 different low-risk types per lesion.
  • Histologically, 7 (35%), 7 (35%), and 6 (30%) of the patients had AIN grade I, II, or III, respectively.
  • Four different types of clinical presentation could be distinguished in the 20 patients with AIN: bowenoid (1 case, 5%); erythroplakic (2 cases, 10%); verrucous (6 cases, 30%); and leukoplakic (11 cases, 55%).
  • All verrucous lesions were graded as high-grade intraepithelial lesions in cytology, whereas 6 of the 11 leukoplakic lesions (55%) were low grade.
  • All verrucous AIN carried at least 4 different HPV types, always including HPV-16, and the mean number of HPV types was higher in verrucous lesions than in leukoplakic lesions (5.5 vs 3.8, respectively).
  • CONCLUSION: These data confirm the high incidence and prevalence of AIN in patients who are HPV positive with HIV infection.
  • Four different clinical types of AIN can be distinguished that might have prognostic implications.
  • Standardized screening programs for anal cancer prevention and treatment protocols for AIN in patients infected with HIV must be implemented.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. HIV Seropositivity / complications. Papillomaviridae / isolation & purification

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15793509.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


16. Kreuter A, Skrygan M, Gambichler T, Brockmeyer NH, Stücker M, Herzler C, Potthoff A, Altmeyer P, Pfister H, Wieland U: Human papillomavirus-associated induction of human beta-defensins in anal intraepithelial neoplasia. Br J Dermatol; 2009 Jun;160(6):1197-205
MedlinePlus Health Information. consumer health - HIV/AIDS and Infections.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus-associated induction of human beta-defensins in anal intraepithelial neoplasia.
  • OBJECTIVES: The present study was performed to analyse expression of AMPs in human papillomavirus (HPV)-associated anal skin lesions of human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), a special high-risk group for persistent HPV infections and anal dysplasia.
  • RESULTS: Skin biopsies of 45 HIV-positive MSM with anal intraepithelial neoplasia (AIN), anal condylomata acuminata or unaffected anal mucosa, as well as condylomata acuminata of eight HIV-negative MSM, were analysed for AMP mRNA expression.
  • Additionally, immunohistochemical analysis for hBD-2 and hBD-3 was performed in a total of 45 samples. hBD-2 and hBD-3 gene and protein expression was significantly increased in both AIN and condyloma, whereas LL-37, RNase 7 and hBD-1 gene expression did not differ significantly from unaffected anal mucosa.
  • CONCLUSIONS: hBD-2 and hBD-3 expression was shown to be significantly upregulated in HPV-associated anal skin lesions of both HIV-positive and HIV-negative MSM.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Anus Neoplasms / metabolism. Papillomavirus Infections / metabolism. beta-Defensins / metabolism

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19298269.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / beta-Defensins; 0 / beta-defensin 3, human
  •  go-up   go-down


17. Bean SM, Eltoum I, Horton DK, Whitlow L, Chhieng DC: Immunohistochemical expression of p16 and Ki-67 correlates with degree of anal intraepithelial neoplasia. Am J Surg Pathol; 2007 Apr;31(4):555-61
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of p16 and Ki-67 correlates with degree of anal intraepithelial neoplasia.
  • Anal intraepithelial neoplasia (AIN) is a human papilloma virus related lesion.
  • The objective of this study is to correlate p16 expression and cellular proliferation measured by Ki-67 staining with the degree of dysplasia in the anal canal and to determine the efficacy of these markers in diagnosing high-grade AIN.
  • Seventy-five anal specimens from 55 patients (37 men; 18 women; mean age: 48 y; median: 44 y; range 25 to 96 y) were studied including 35 normal/reactive lesions, 23 low-grade AIN (AIN I and condyloma), and 17 high-grade AIN (AIN II and III).
  • Expression of p16 in AIN correlated with that of Ki-67 (P<0.001).
  • High-grade AIN often demonstrated p16 staining in more than one-third of the thickness of the epithelium in a diffuse/continuous fashion. p16 expression in low-grade AIN was often restricted to the lower 1/3 of the epithelium and/or was focal and discontinuous.
  • The expression of both p16 and Ki-67 correlated with the degree of dysplasia (P<0.01).
  • When positive p16 staining was defined as the presence of diffuse/continuous staining in more than one-third of the thickness of epithelium, the sensitivity, specificity, and accuracy of p16 as a marker for diagnosing high-grade AIN were 76%, 86%, and 84%, respectively.
  • When positive Ki-67 staining was defined as the presence of nuclear staining in more than 25% of the cells in more than one-third of the thickness of epithelium, the sensitivity, specificity, and accuracy of Ki-67 as a marker for diagnosing high-grade AIN were 71%, 84%, and 83% respectively.
  • Both p16 and Ki-67 are reliable markers for diagnosing high-grade AIN.
  • [MeSH-major] Anus Neoplasms / diagnosis. Genes, p16. Ki-67 Antigen / metabolism. Papillomavirus Infections / diagnosis. Precancerous Conditions / diagnosis. Tumor Virus Infections / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / virology. Female. History, 17th Century. Humans. Immunohistochemistry. Male. Sensitivity and Specificity

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17414102.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
  •  go-up   go-down


18. Kreuter A, Jesse M, Potthoff A, Brockmeyer NH, Gambichler T, Stücker M, Bechara FG, Pfister H, Wieland U: Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men. J Am Acad Dermatol; 2010 Sep;63(3):490-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated precursor lesion of anal carcinoma, is highly prevalent among HIV-infected individuals, especially in men having sex with men (MSM).
  • Early diagnosis and treatment of AIN might prevent development of anal cancer.
  • OBJECTIVES: We aimed to evaluate the expression of 8 promising proliferative biomarkers in anal dysplasia and to compare the efficacy of these markers in diagnosing high-grade AIN.
  • METHODS: Immunohistochemical analysis of minichromosome maintenance proteins (MCM3, MCM4, MCM6, and MCM7), p21, Ki-67, p16, and proliferating cell nuclear antigen (PCNA) was performed in a total of 49 specimens of normal anal mucosa and high- and low-grade anal dysplasia.
  • In the progression from normal epithelium to high-grade dysplasia, we found significant differences in the expression of all biomarkers.
  • A cutoff of 25% or 50% lesional immunopositivity for the 4 MCMs, Ki-67, and p16 resulted in 100% sensitivity and 100% specificity to diagnose high-grade AIN.
  • Sensitivity and specificity of PCNA and p21 for a high-grade AIN diagnosis were lower.
  • HPV-DNA was detectable in 100% of high-grade AIN and 87.5% of low-grade AIN lesions.
  • CONCLUSIONS: MCMs, Ki67, and p16 are reliable immunohistochemical adjuncts for diagnosing high-grade AIN.
  • [MeSH-major] Anus Neoplasms / pathology. Biomarkers, Tumor / analysis. Carcinoma in Situ / pathology. HIV Infections / diagnosis. Proliferating Cell Nuclear Antigen / metabolism
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Antiretroviral Therapy, Highly Active / methods. Biopsy, Needle. DNA, Viral / analysis. HIV Seropositivity. Homosexuality, Male. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Staging. Papillomavirus Infections / complications. Papillomavirus Infections / diagnosis. Polymerase Chain Reaction / methods. Precancerous Conditions / pathology. Reference Values. Risk Assessment. Sensitivity and Specificity. Viral Load. Young Adult

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • HIV InSite. treatment guidelines - Human Herpesvirus-8 .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20006407.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Viral; 0 / Proliferating Cell Nuclear Antigen
  •  go-up   go-down


19. Wieland U, Brockmeyer NH, Weissenborn SJ, Hochdorfer B, Stücker M, Swoboda J, Altmeyer P, Pfister H, Kreuter A: Imiquimod treatment of anal intraepithelial neoplasia in HIV-positive men. Arch Dermatol; 2006 Nov;142(11):1438-44
Hazardous Substances Data Bank. Imiquimod .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imiquimod treatment of anal intraepithelial neoplasia in HIV-positive men.
  • OBJECTIVE: To evaluate the treatment of anal intraepithelial neoplasia (AIN) with the local immune response modifier imiquimod in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM).
  • Patients Twenty-eight consecutive HIV-positive MSM with histologically confirmed perianal (n = 23) or intra-anal (n = 5) AIN.
  • Intervention Overnight treatment with self-applied imiquimod cream (perianal AIN) or suppositories (intra-anal AIN) 3 times a week for 16 weeks.
  • RESULTS: Seventeen (61%) of all 28 patients included in the study and 17 (77%) of the 22 patients with AIN, who applied imiquimod as instructed, showed clinical and histologic clearance at the end of therapy.
  • Four patients had residual AIN and 1 patient did not improve.
  • In the follow-up period, AIN cleared in 3 patients with residual AIN.
  • CONCLUSIONS: Imiquimod appears to be a safe and effective treatment option for AIN in HIV-positive MSM.
  • These results should encourage controlled randomized studies of imiquimod treatment of AIN.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. HIV Infections


20. Bernard JE, Butler MO, Sandweiss L, Weidner N: Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization. Appl Immunohistochem Mol Morphol; 2008 May;16(3):215-20
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization.
  • Accurate diagnosis and grading of anal intraepithelial neoplasia (AIN) can be problematic, especially in separating AIN from anal transitional-zone epithelium.
  • To investigate if p16 would help in more accurately diagnosing and grading AIN, particularly when attempting to distinguish benign transitional-zone epithelium from high-grade AIN, we separately assessed these stains in a blinded manner on a large number of consecutive anal biopsies and anal tissues and correlated the findings with the diagnosis and grade of AIN.
  • One hundred thirty-three consecutive anal tissue specimens, from 128 patients were studied.
  • One hundred and eight were anal biopsies and 25 were hemorrhoidectomy specimens.
  • The comparisons included AIN grade (negative, 1, 2, 3) with nuclear intensity of p16 IHC (0 to 3+), AIN grade with IHC nuclear staining patterns (contiguous, patchy/rare), AIN grade with HPV-ISH [negative, low-risk (LR), high-risk (HR)] and, nuclear intensity of p16 IHC with HPV-ISH.
  • Yet, 33% of AIN negative cases were positive for nuclear p16, although with less nuclear intensity than for AIN2 or 3.
  • The kappa value for AIN/nuclear p16 intensity agreement was 0.61 (ie, substantial agreement).
  • Yet, 12.5% of AIN negative cases were positive for HPV for both LR and HR types.
  • The kappa value for AIN/HPV agreement was 0.62 (ie, substantial agreement).
  • Of interest, 30 cases were negative for AIN and p16 staining and of these, 2 (7%) were positive for HPV (both LR subtype).
  • Three cases positive for HR HPV were negative for AIN with only patchy nuclear p16 positivity.
  • We conclude that the correlation between AIN and p16 and HPV is strong enough to be quite useful in distinguishing true AIN from benign mimics, such as benign transitional-zone epithelium.

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18301250.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA Probes, HPV
  •  go-up   go-down


21. von Knebel Doeberitz M, Reuschenbach M: [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus]. Hautarzt; 2010 Jan;61(1):13-20
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus].
  • [Transliterated title] Humane Papillomviren in der Pathogenese der intraepithelialen Neoplasien (AIN) und Karzinome des Anus.
  • HPV infections have been implicated in the pathogenesis of anal cancers.
  • [MeSH-major] Anus Neoplasms / virology. Biomarkers, Tumor / analysis. Carcinoma in Situ / physiopathology. Papillomavirus Infections / diagnosis. Papillomavirus Infections / virology. Precancerous Conditions / virology

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20033115.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  •  go-up   go-down


22. Pirog EC, Quint KD, Yantiss RK: P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction. Am J Surg Pathol; 2010 Oct;34(10):1449-55
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction.
  • The classification of anal intraepithelial neoplasia (AIN) in mucosal biopsies is subject to considerable interobserver variability.
  • Previous studies have shown that Ki-67 and p16/CDKN2A immunostains aid detection of dysplasia in biopsy samples from the uterine cervix.
  • The aim of this study was to determine whether Ki-67 and p16/CDKN2A immunolabeling enhanced diagnostic accuracy in the assessment of anal mucosal biopsies from patients with suspected human papillomavirus (HPV) infection.
  • The study consisted of 75 cases that were originally interpreted to represent normal anal transitional zone (n=15), fibroepithelial polyp (n=10), condyloma accuminatum (n=10), low-grade AIN (AIN1, n=20), and high-grade AIN (n=20), including 10 cases each of AIN2 and AIN3.
  • Thus, the final study group consisted of 17 samples of normal anal transition zone, 14 fibroepithelial polyps, 6 condylomata accuminata, and 38 cases of AIN (11 AIN1, 16 AIN2, and 11 AIN3).
  • A positive Ki-67 result was defined as the presence of a cluster of at least 2 strongly stained epithelial nuclei in the upper two-thirds of the epithelial thickness.
  • None of the anal transition zone samples or fibroepithelial polyps showed Ki-67 or p16/CDKN2A staining.
  • All condylomata and samples of AIN contained HPV DNA and showed positive Ki-67 labeling.
  • All cases of high-grade AIN showed positive p16/CDKN2A staining.
  • We conclude that Ki-67 labeling detects anal HPV-related changes with a high degree of sensitivity and specificity, whereas increased p16/CDKN2A staining is strongly associated with high-grade squamous neoplasia.
  • These results indicate that a combination of these markers may aid interpretation of anal mucosal biopsy samples.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Condylomata Acuminata / diagnosis. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ki-67 Antigen / metabolism. Papillomaviridae / isolation & purification. Papillomavirus Infections / diagnosis
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Biopsy. Colonic Polyps / metabolism. Colonic Polyps / pathology. Colonic Polyps / virology. DNA Probes, HPV. Female. Humans. Immunohistochemistry. Male. Middle Aged. Precancerous Conditions / diagnosis. Precancerous Conditions / metabolism. Precancerous Conditions / virology. Predictive Value of Tests. Young Adult

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Genital Warts.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20871219.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA Probes, HPV; 0 / Ki-67 Antigen
  •  go-up   go-down


23. Gagne SE, Jensen R, Polvi A, Da Costa M, Ginzinger D, Efird JT, Holly EA, Darragh T, Palefsky JM: High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia. J Acquir Immune Defic Syndr; 2005 Oct 1;40(2):182-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia.
  • Anal intraepithelial neoplasia (AIN) is the likely precursor to anal cancer.
  • AIN is associated with human papillomavirus (HPV) infection, and HPV-associated genomic instability may play an important role in the progression of squamous intraepithelial neoplasia to cancer.
  • Microarray-based comparative genome hybridization (aCGH) was performed on DNA from AIN specimens to determine the host genomic alterations and their correlation with HPV DNA integration or rearrangement.
  • Of 27 high-grade AIN specimens tested by CGH, 8 (30%) showed regional DNA copy number abnormalities (CNAs).
  • Our data suggest that there may be several oncogenes in this region that are coactivated to contribute to progression to high-grade AIN.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Genome, Viral. Papillomaviridae / physiology. Virus Integration

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16186736.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / R01CA54053; United States / NCI NIH HHS / CA / U01 CA66529; United States / NCI NIH HHS / CA / U01 CA70019
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  •  go-up   go-down


24. Richel O, Wieland U, de Vries HJ, Brockmeyer NH, van Noesel C, Potthoff A, Prins JM, Kreuter A: Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men. Br J Dermatol; 2010 Dec;163(6):1301-7
Hazardous Substances Data Bank. FLUOROURACIL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-induced potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM).
  • So far, only a few prospective studies have been performed on the topical treatment of AIN, especially at the intra-anal location.
  • OBJECTIVES: To evaluate the efficacy and safety of self-administered topical 5-fluorouracil (5-FU) treatment of AIN in HIV-positive MSM.
  • METHODS: High-resolution anoscopy (HRA) was performed and patients with AIN (grade 1-3) were treated with 5-FU twice weekly for a total of 16 weeks.
  • RESULTS: A total of 46 patients with AIN were included in this open prospective pilot study; 76% had multifocal disease and 74% had high-grade lesions (AIN 2 or 3).
  • Eighteen patients (39%) had a complete clearance of AIN and eight patients (17%) had a partial response.
  • Seventeen patients (37%) did not respond (unchanged grade of AIN in 16 patients and progression from low- to high-grade AIN in one patient).
  • CONCLUSIONS: A substantial proportion of HIV-positive MSM with AIN completely cleared their lesions with topical 5-FU treatment.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Anus Neoplasms / drug therapy. Fluorouracil / therapeutic use. HIV Infections / complications

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20716208.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
  •  go-up   go-down


25. Alvarez J, de Pokomandy A, Rouleau D, Ghattas G, Vézina S, Coté P, Allaire G, Hadjeres R, Franco EL, Coutlée F, HIPVIRG Study Group: Episomal and integrated human papillomavirus type 16 loads and anal intraepithelial neoplasia in HIV-seropositive men. AIDS; 2010 Sep 24;24(15):2355-63
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Episomal and integrated human papillomavirus type 16 loads and anal intraepithelial neoplasia in HIV-seropositive men.
  • OBJECTIVES: To assess levels of episomal and integrated human papillomavirus type 16 (HPV-16) loads in HIV-seropositive men who have sex with men (MSM) in anal infection and to study the association between episomal and integrated HPV-16 loads and anal intraepithelial neoplasia (AIN).
  • Overall, 135 (54.7%) men provided 665 HPV-16-positive anal samples.
  • RESULTS: The HPV-16 DNA forms in anal samples were characterized as episomal only in 627 samples (94.3%), mixed in 22 samples (3.3%) and integrated only in nine samples (1.4%).
  • HPV-16 episomal load [odds ratio (OR) = 1.5, 95% confidence interval (CI) 1.1-2.1], number of HPV types (OR = 1.4, 95% CI 1.1-1.8) and current smoking (OR = 4.8, 95% CI 1.3-18.6) were associated with high-grade AIN (AIN-2,3) after adjusting for age and CD4 cell counts.
  • Integrated HPV-16 load was not associated with AIN-2,3 (OR = 0.7, 95% CI 0.4-1.1).
  • Considering men with AIN-1 at baseline, four (16.7%) of the 24 men who progressed to AIN-2,3 had at least one sample with integrated HPV-16 DNA compared with three (23.1%) of 13 men who did not progress (OR = 0.7, 95% CI 0.2-3.8; P = 0.64).
  • Integration was detected in similar proportions in samples from men without AIN, with AIN-1 or AIN-2,3.
  • CONCLUSION: High episomal HPV-16 load but not HPV-16 integration load measured by real-time PCR was associated with AIN-2,3.
  • [MeSH-major] Anus Neoplasms / immunology. Carcinoma, Squamous Cell / immunology. HIV Seropositivity / immunology. Human papillomavirus 16 / immunology. Papillomavirus Infections / immunology. Plasmids / immunology

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20706109.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Investigator] Allaire G; Baril JG; Boissonnault M; Charest L; Charron MA; Coté S; Coté P; Coutlée F; de Pokomandy A; Dion H; Dufresne S; Falutz J; Fortin C; Franco EL; Ghattas G; Gilmore N; Gorska I; Hadjeres R; Junod P; Klein M; Lalonde R; Laplante F; Leblanc R; Legault D; Lessard B; Longpré D; McLeod J; Maziade JP; Murphy D; Nguyen VK; O'Brien R; Phaneuf D; Rouleau D; Routy JP; Szabo J; Tessier D; Thomas R; Toma E; Tremblay C; Trépanier JM; Trottier B; Tsoukas C; Turner H; Vezina S
  •  go-up   go-down


26. Chin-Hong PV, Berry JM, Cheng SC, Catania JA, Da Costa M, Darragh TM, Fishman F, Jay N, Pollack LM, Palefsky JM: Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men. Ann Intern Med; 2008 Sep 2;149(5):300-6
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men.
  • BACKGROUND: Human papillomavirus (HPV)-associated anal cancer is increasing in prevalence and is more common among men who have sex with men and HIV-positive individuals than cervical cancer is among women in the United States.
  • Cytology screening can detect the anal cancer precursor, anal intraepithelial neoplasia (AIN).
  • Little is known about self-collected samples for AIN screening, and few community-based AIN estimates exist.
  • OBJECTIVE: To compare the sensitivity of self-collected versus clinician-collected anal cytology specimens to detect biopsy-confirmed AIN and the prevalence estimate of AIN in a community sample.
  • Participants were mailed anal cytology self-collection kits with instructions.
  • Clinicians repeated anal cytology and performed high-resolution anoscopy with biopsies as the diagnostic reference standard.
  • MEASUREMENTS: Prevalence of anal HPV and AIN.
  • Sensitivity and specificity of self-collected and clinician-collected anal cytology specimens to diagnose AIN were calculated.
  • RESULTS: Biopsy-proven AIN was diagnosed in 57% of HIV-positive and 35% of HIV-negative participants (P = 0.04), and 80% provided adequate self-collected specimens for interpretation.
  • The sensitivity of cytology to detect AIN in HIV-positive men was 75% (95% CI, 51% to 93%) when self-collected and 90% (CI, 68% to 99%) when clinician-collected; respective values in HIV-negative men were 48% (CI, 26% to 70%) and 62% (CI, 38% to 82%).
  • The specificity of cytology to detect AIN in HIV-positive men was 50% (CI, 22% to 78%) when self-collected and 64% (CI, 36% to 86%) when clinician-collected; respective values in HIV-negative men were 86% (CI, 71% to 94%) and 85% (CI, 72% to 93%).
  • CONCLUSION: In a community-based sample, a high proportion of HIV-positive and HIV-negative men who have sex with men have AIN.
  • The sensitivity of cytology to detect AIN is higher for clinician-collected versus self-collected specimens and for HIV-positive versus HIV-negative men.
  • The specificity of cytology to detect AIN is higher in HIV-negative versus HIV-positive men.
  • However, the probability of AIN in a patient with a negative cytology result may not be low enough (23% for HIV-negative men and 45% for HIV-positive men with a patient-collected specimen) for clinicians to be comfortable recommending no anoscopy for those with a negative cytology result if done as a one-time test.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Cytological Techniques / methods. Homosexuality. Papillomavirus Infections / pathology. Specimen Handling / methods
  • [MeSH-minor] Adult. Aged. Anal Canal / pathology. Biopsy. Endoscopy, Gastrointestinal. HIV Seronegativity. HIV Seropositivity / epidemiology. HIV Seropositivity / pathology. HIV Seropositivity / virology. Humans. Male. Middle Aged. Prevalence. San Francisco / epidemiology. Sensitivity and Specificity

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Gay, Lesbian, Bisexual, and Transgender Health.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Ann Intern Med. 2009 Feb 17;150(4):283-4; author reply 284-5 [19221387.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2008 Sep 2;149(5):I38 [18765696.001]
  • (PMID = 18765699.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NIAID NIH HHS / AI / K23 AI054157; United States / NIAID NIH HHS / AI / R01 CA/AI 88739; United States / NCI NIH HHS / CA / R01 CA54053; United States / NIMH NIH HHS / MH / R01 MH54320
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


27. Palefsky JM, Holly EA, Efirdc JT, Da Costa M, Jay N, Berry JM, Darragh TM: Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS; 2005 Sep 2;19(13):1407-14
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men.
  • OBJECTIVES: The incidence of anal cancer among men who have sex with men (MSM) has continued to increase since the introduction of highly active antiretroviral therapy (HAART).
  • The prevalence of the putative anal cancer precursor, anal intraepithelial neoplasia (AIN) was high among HIV-positive MSM prior to the availability of HAART but little is known about AIN since HAART was introduced.
  • We characterized the prevalence of AIN among HIV-positive MSM and examined the association between AIN and various factors including use of HAART.
  • DESIGN AND METHODS: A baseline point-prevalence analyses in a prospective cohort study of AIN was performed at a university-based research clinic.
  • A total of 357 HIV-positive MSM with no history of anal cancer completed a questionnaire detailing behaviors and medical history, anal cytology and human papillomavirus (HPV) testing, and high-resolution anoscopy with biopsy for detection of AIN.
  • RESULTS: Eighty-one percent of participants with available CD4+ cell counts at baseline had AIN of any grade; 52% had AIN 2 or 3; and 95% had anal HPV infection.
  • In multivariate analysis, detection of > or = 6 HPV types [odds ratio (OR), 36; 95% confidence interval (CI), 7.4-171) and use of HAART (OR, 10; 95% CI, 2.6-38) were associated with AIN after adjustment for length of time participants were HIV-positive, CD4+ cell count and HIV viral load.
  • CONCLUSIONS: The prevalence of AIN has remained high among HIV-positive MSM after the introduction of HAART.
  • Our data indicate that HAART is not associated with a reduced prevalence of AIN and support measures to prevent anal cancer among HIV-positive MSM whether or not they are using HAART.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. HIV Infections / complications. Homosexuality, Male

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • COS Scholar Universe. author profiles.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16103772.001).
  • [ISSN] 0269-9370
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / R01CA54053
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-HIV Agents
  •  go-up   go-down


28. Walts AE, Lechago J, Bose S: P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia. Am J Surg Pathol; 2006 Jul;30(7):795-801
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia.
  • HPV is also associated with anal squamous dysplasias and carcinomas.
  • Significant interobserver and intraobserver variation exists in the interpretation of biopsies for anal intraepithelial neoplasia (AIN).
  • This study was undertaken to assess the potential role of p16 and Ki67 immunohistochemical expression in refining the diagnosis and grading of AIN.One-hundred and four anal biopsies from 74 patients were retrieved from the surgical pathology files of the department.
  • After discrepancies were resolved and concurrence was achieved by at least 2 of 3 reviewing pathologists, the diagnoses were as follows: 37 negative, 12 condylomas without overt dysplasia, 14 AIN I, 25 AIN II, and 16 AIN III. p16 and Ki67 expression was evaluated by ABC immunoperoxidase staining whereas the presence of the high-risk subtypes of HPV virus was determined by in situ hybridization on a subset of the biopsies.
  • Nuclear and/or nuclear and cytoplasmic staining was considered as positive for p16 when present in >10% of squamous cells.
  • A band-like pattern of p16 immunoreactivity was seen in 21.4% AIN I, 80% AIN II, and 87.5% AIN III cases.
  • Spotty p16 immunoreactivity was observed in 8.1% negative, 8.3% condyloma, 14.3% AIN I, 12.0% AIN II, and 12.5% AIN III cases.
  • More than 50% of nuclei stained positive for Ki67 in 28.6% AIN I, 48.0% AIN II, and 75.0% AIN III cases but in none of the negative or condyloma cases.
  • On the basis of these results, a band-like pattern of p16 staining and Ki67 positivity in >50% of the squamous cell nuclei were strongly associated with high-grade AIN.
  • Most AIN I lesions stained similar to the nondysplastic cases.
  • A small subset of biopsies studied did not conform to the pattern described above: 4 of 14 (28.6%) AIN I lesions showed a band-like pattern of p16 staining and/or >50% Ki67 positive nuclei.
  • 4 of 25 (16.0%) AIN II lesions comprising 9.8% of the 41 high-grade AINs (AIN II and III) showed spotty p16 positivity and <50% Ki67 positive nuclei.
  • We conclude that when used together and evaluated in conjunction with H&E stained sections, p16 and Ki67 immunoexpression is a useful adjunct in the diagnosis and grading of AIN.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ki-67 Antigen / metabolism. Papillomavirus Infections / pathology. Precancerous Conditions / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16819320.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / Ki-67 Antigen
  •  go-up   go-down


29. Singh JC, Kuohung V, Palefsky JM: Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men. J Acquir Immune Defic Syndr; 2009 Dec 1;52(4):474-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), particularly AIN 3 is a precursor to anal cancer.
  • Most cases of AIN are intraanal, but few treatments for intraanal AIN are currently available.
  • Topical 85% trichloroacetic acid (TCA) is an inexpensive method used to treat perianal condyloma, a form of AIN 1, but its efficacy to treat intraanal AIN as first-line therapy is unknown.
  • METHODS: Retrospective review of medical records was performed for all patients with AIN treated at the University of California San Francisco Anal Neoplasia Clinic with TCA as the first-line therapy from January 2000 to December 2004.
  • Clearance was defined as the absence of AIN confirmed by high-resolution anoscopy and cytology after up to 4 TCA treatments.
  • 32% of patients with AIN 2/3 cleared to no lesions.
  • On a per lesion basis, 73% of AIN 1 and 71% AIN 2/3 cleared to no lesion or AIN 1 or less, respectively.
  • A high proportion of AIN 2/3 lesions responded to TCA treatment.

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - HIV/AIDS Medicines.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • Hazardous Substances Data Bank. TRICHLOROACETIC ACID .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Semin Oncol. 2000 Aug;27(4):471-9 [10950374.001]
  • [Cites] Oncologist. 2007 May;12(5):524-34 [17522240.001]
  • [Cites] J Natl Cancer Inst. 2000 Sep 20;92(18):1500-10 [10995805.001]
  • [Cites] Clin Infect Dis. 2002 Nov 1;35(9):1127-34 [12384848.001]
  • [Cites] CA Cancer J Clin. 2003 Jan-Feb;53(1):5-26 [12568441.001]
  • [Cites] Eur J Med Res. 2003 Apr 30;8(4):142-6 [12765859.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):638-42 [12869403.001]
  • [Cites] Dis Colon Rectum. 2003 Nov;46(11):1517-23; discussion 1523-4; author reply 1524 [14605572.001]
  • [Cites] Sex Transm Dis. 2004 Feb;31(2):96-9 [14743072.001]
  • [Cites] Cancer. 2004 Jul 15;101(2):281-8 [15241824.001]
  • [Cites] Am J Med Sci. 2004 Jul;328(1):57-63 [15254442.001]
  • [Cites] N Engl J Med. 1987 Oct 15;317(16):973-7 [2821396.001]
  • [Cites] J Natl Cancer Inst. 1989 Nov 15;81(22):1726-31 [2810388.001]
  • [Cites] Obstet Gynecol. 1994 Feb;83(2):205-11 [8290181.001]
  • [Cites] J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 15;14(5):415-22 [9170415.001]
  • [Cites] J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 1;17(4):314-9 [9525431.001]
  • [Cites] Lancet. 1998 Jun 20;351(9119):1833-9 [9652666.001]
  • [Cites] Semin Cancer Biol. 1998 Aug;8(4):307-13 [9870037.001]
  • [Cites] J Acquir Immune Defic Syndr. 1999 Aug 1;21 Suppl 1:S42-8 [10430218.001]
  • [Cites] Br J Surg. 2005 Mar;92(3):277-90 [15736144.001]
  • [Cites] J Clin Virol. 2005 Mar;32 Suppl 1:S82-90 [15753016.001]
  • [Cites] AIDS. 2005 Sep 2;19(13):1407-14 [16103772.001]
  • [Cites] MMWR Recomm Rep. 2006 Aug 4;55(RR-11):1-94 [16888612.001]
  • [Cites] ANZ J Surg. 2006 Aug;76(8):715-7 [16916390.001]
  • [Cites] Hautarzt. 2006 Nov;57(11):994-8 [17051407.001]
  • [ErratumIn] J Acquir Immune Defic Syndr. 2012 Jul 1;60(3):e105-6
  • (PMID = 19779306.001).
  • [ISSN] 1944-7884
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000079; United States / NCRR NIH HHS / RR / RR000079-420472; United States / NCRR NIH HHS / RR / UL1 RR024131; United States / NCRR NIH HHS / RR / M01 RR000079-420472
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5V2JDO056X / Trichloroacetic Acid
  • [Other-IDs] NLM/ NIHMS149443; NLM/ PMC2871540
  •  go-up   go-down


30. Sanclemente G, Herrera S, Tyring SK, Rady PL, Zuleta JJ, Correa LA, He Q, Wolff JC: Human papillomavirus (HPV) viral load and HPV type in the clinical outcome of HIV-positive patients treated with imiquimod for anogenital warts and anal intraepithelial neoplasia. J Eur Acad Dermatol Venereol; 2007 Sep;21(8):1054-60
Hazardous Substances Data Bank. Imiquimod .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus (HPV) viral load and HPV type in the clinical outcome of HIV-positive patients treated with imiquimod for anogenital warts and anal intraepithelial neoplasia.
  • OBJECTIVE: To evaluate the efficacy of 5% imiquimod in HIV-positive male patients with anogenital warts or anal intraepithelial neoplasia (AIN), and to elucidate whether human papillomavirus (HPV) type and viral load were important for clinical outcome and recurrences.
  • METHODS: Thirty-seven patients with histologically proven anogenital warts or AIN were enrolled.
  • The perianal area was the main lesion location.
  • Eighteen patients had a histopathological diagnosis of AIN-1.
  • CONCLUSIONS: The assumption that visible perianal warts are benign lesions in HIV-positive patients has to be reevaluated since an important number of such lesions could correspond to low-grade anal disease, which in turn could progress to high-grade anal disease or cancer.
  • In addition, our results in this preliminary study indicate that imiquimod appears to be effective in treating AIN in HIV-positive patients.
  • Further studies are needed to document its utility to prevent high-grade dysplasia and/or anal cancer.
  • [MeSH-major] AIDS-Related Opportunistic Infections / drug therapy. Adjuvants, Immunologic / therapeutic use. Aminoquinolines / therapeutic use. Anus Diseases / drug therapy. Anus Neoplasms / drug therapy. Condylomata Acuminata / drug therapy. Genital Diseases, Male / drug therapy. Papillomavirus Infections / drug therapy


31. Kreuter A, Wieland U, Gambichler T, Altmeyer P, Pfister H, Tenner-Racz K, Racz P, Potthoff A, Brockmeyer NH, German Network of Competence HIV/AIDS: p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load. Br J Dermatol; 2007 Sep;157(3):523-30
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load.
  • In this context, a drastically increased relative risk for anal intraepithelial neoplasia (AIN) exists in HIV-infected men having sex with men (MSM).
  • In a pilot study, imiquimod, a topical immune response modifier, has been reported to be beneficial in the treatment of AIN.
  • OBJECTIVES: To investigate the role of several biomarkers as potential adjuncts in the course of imiquimod treatment for AIN, and to determine whether these markers correlate with the course of high-risk HPV DNA load during imiquimod therapy.
  • METHODS: Immunohistochemical staining was performed for p16(ink4a), minichromosome maintenance protein (MCM), Ki67, proliferating cell nuclear antigen (PCNA) and p21(waf1) expression before and after 16 weeks of imiquimod treatment for AIN.
  • RESULTS: Histopathological and virological analyses were performed in 21 HIV-infected MSM with histologically confirmed AIN.
  • Eighteen (86%) patients had a complete histological clearance of AIN after imiquimod therapy.
  • A significant correlation between the course of high-risk HPV DNA load and p16(ink4a) expression was observed during imiquimod treatment of AIN, whereas the decline of high-risk HPV DNA load did not significantly correlate with MCM, Ki67, PCNA or p21(waf1) expression.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Precancerous Conditions / drug therapy

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • Hazardous Substances Data Bank. Imiquimod .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17573882.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00365729
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / Ki-67 Antigen; 99011-02-6 / imiquimod
  •  go-up   go-down


32. Scott H, Khoury J, Moore BA, Weissman S: Routine anal cytology screening for anal squamous intraepithelial lesions in an urban HIV clinic. Sex Transm Dis; 2008 Feb;35(2):197-202
MedlinePlus Health Information. consumer health - HIV/AIDS in Women.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Routine anal cytology screening for anal squamous intraepithelial lesions in an urban HIV clinic.
  • OBJECTIVES: The purpose of this study is to describe our experience with routine anal cancer screening using anal cytology, determine risk factors for abnormal anal cytology, and determine if an association exists between cytology and histology in patients with HIV infection.
  • RESULTS: Overall, 276 of 560 of the clinic patients received a screening anal cytology during the study period.
  • Of these patients, 11 were excluded from the analysis and 74 of 265 (27.9%) patients screened had an abnormal anal cytology.
  • Forty-nine percent were African American, 34% Caucasian, and 17% Hispanic.
  • They were also more likely to have a lower CD4+ nadir (142 cells/mm3 vs. 223 cells/mm3, P = 0.005) and CD4+ at time of anal cytology (353 cells/mm3 vs. 497 cells/mm3, P <0.001).
  • Those with an abnormal anal cytology also had higher occurrence of anal disease on perianal visual inspection (30% vs. 9%, P <0.001) and were more likely to have a history of genital warts (23% vs. 12%, P = 0.02) or herpes (35% vs. 22%, P = 0.02).
  • Two patients had anal intraepithelial neoplasia (AIN) I, 2 AIN II, 3 AIN III, and 2 squamous cell carcinoma in situ on histology.
  • CONCLUSION: Routine anal cytology screening is a feasible tool to incorporate into HIV care for patients regardless of gender and HIV risk factors.
  • [MeSH-major] Anus Neoplasms / diagnosis. HIV Infections / complications. Neoplasms, Squamous Cell / pathology. Urban Health Services / organization & administration
  • [MeSH-minor] Adult. Aged. Anal Canal / pathology. Colonoscopy / methods. Female. Follow-Up Studies. Humans. Logistic Models. Male. Middle Aged. Multivariate Analysis

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18216727.001).
  • [ISSN] 0148-5717
  • [Journal-full-title] Sexually transmitted diseases
  • [ISO-abbreviation] Sex Transm Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


33. Hampl M, Sarajuuri H, Wentzensen N, Bender HG, Kueppers V: Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer. Obstet Gynecol; 2006 Dec;108(6):1361-8
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer.
  • OBJECTIVE: Human papillomavirus (HPV) is a necessary cause for cervical cancer, and it has been associated with vulvar and vaginal cancer and vulvar (VIN) and vaginal (VaIN) and anal (AIN) intraepithelial neoplasia.
  • METHODS: Two hundred fifty-eight samples of VIN, VaIN, AIN, and vulvar cancer from 241 women were included in the study.
  • The diagnosis of surgical samples was made using published histomorphologic criteria.
  • RESULTS: The analyses were performed on 210 intraepithelial neoplasia samples (VIN2/3, VaIN2/3, AIN2/3) and 48 vulvar carcinoma samples.
  • Human papillomavirus DNA was detected in 92%, 91%, 89%, and 60% of the VIN, VaIN, AIN, and vulvar carcinoma samples, respectively.
  • High-risk HPV types 16 or 18 were detected in 76%, 64%, 81%, and 42% of the VIN2/3, VaIN2/3, AIN, and vulvar carcinoma samples.
  • CONCLUSION: Based on the data obtained in this study, widely-implemented prophylactic HPV vaccination could make an important contribution to the reduction of the risk for cervical cancer and could also prevent about half the vulvar carcinomas in younger women and about two thirds of the intraepithelial lesions in the lower genital tract.


34. Gohy L, Gorska I, Rouleau D, Ghattas G, Pokomandy Ad, Vézina S, Coté P, Macleod J, Allaire G, Hadjeres R, Kornegay JR, Franco E, HIPVIRG Study Group, Coutlée F: Genotyping of human papillomavirus DNA in anal biopsies and anal swabs collected from HIV-seropositive men with anal dysplasia. J Acquir Immune Defic Syndr; 2008 Sep 1;49(1):32-9
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genotyping of human papillomavirus DNA in anal biopsies and anal swabs collected from HIV-seropositive men with anal dysplasia.
  • BACKGROUND: Human papillomavirus (HPV) causes anal intraepithelial neoplasia (AIN) in HIV-seropositive men.
  • The detection of HPV genotypes in anal biopsies and swabs was compared.
  • METHODS: HPV DNA was detected in anal swabs and biopsies obtained concurrently from 154 HIV-seropositive men [31 without AIN, 60 low-grade AIN (AIN-1), 62 high-grade AIN (AIN-2,3), and 1 indeterminate AIN] under or eligible to highly active antiretroviral therapy.
  • RESULTS: HPV DNA was detected in 24.2% of normal biopsies compared with 93.5% with AIN-2,3 (P < 0.001) and 88.3% with AIN-1 (P < 0.001).
  • The proportion of biopsies containing multiple genotypes was greater in AIN-1 (n = 21, 35.0%; P = 0.002) and AIN-2,3 (n = 38, 58%; P < 0.001) than in normal biopsies (n = 2, 6.5%).
  • The most frequent genotypes in order of frequency were in AIN-2,3 biopsies HPV-16, 18, 58, and 45 and were in AIN-1 biopsies HPV-6, 11, 16, and 39.
  • Controlling for age, CD4 count, and smoking, the presence of high-risk HPV DNA in biopsies [odds ratio (OR) = 50.8, 95% confidence interval (CI): 13.0 to 199.5] but not in swabs (OR = 2.0, 95% CI: 0.6 to 7.0) was associated with AIN-2,3.
  • CONCLUSIONS: AIN-2,3 was associated with high-risk HPV infection detected in biopsies but not in swabs in men under or starting highly active antiretroviral therapy, possibly due to the presence of HPV foci outside of the neoplastic lesion.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Diseases / virology. Carcinoma in Situ / complications. Carcinoma in Situ / virology. DNA, Viral. HIV Seropositivity / virology

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Disorders.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18667921.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Investigator] OAllaire G; Baril JG; Boissonnault M; Charest L; Charron MA; Cote S; Cote P; Coutlee F; de Pokomandy A; Dion H; Dufresne S; Falutz J; Fortin C; Franco E; Ghattas G; Gilmore N; Gorska I; Hadjeres R; Junod P; Klein M; Lalonde R; Laplante F; Leblanc R; Legault D; Lessard B; Longpre D; Mcleod J; Maziade JP; Murphy D; Nguyen VK; O'Brien R; Phaneuf D; Rouleau D; Routy JP; Szabo J; Tessier D; Thomas R; Toma E; Tremblay C; Trepanier JM; Trottier B; Tsoukas C; Turner H; Vezina S
  •  go-up   go-down


35. Scarpini C, White V, Muralidhar B, Patterson A, Hickey N, Singh N, Mullerat J, Winslet M, Davies RJ, Phillips ML, Stacey P, Laskey RA, Miller R, Nathan M, Coleman N: Improved screening for anal neoplasia by immunocytochemical detection of minichromosome maintenance proteins. Cancer Epidemiol Biomarkers Prev; 2008 Oct;17(10):2855-64
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Improved screening for anal neoplasia by immunocytochemical detection of minichromosome maintenance proteins.
  • PURPOSE: Early detection of anal intraepithelial neoplasia (AIN) and anal squamous cell carcinoma (SCC) by screening will improve clinical outcome.
  • Assessment of anal cytology samples using routine Papanicolaou testing suffers from shortcomings in sensitivity and/or specificity, suggesting that screening tests based on biomarkers may be of value.
  • EXPERIMENTAL DESIGN: We undertook an initial immunohistochemical study of 54 anal tissue samples and validated our findings using an independent prospective cohort study of 235 anal cytology samples from 144 subjects.
  • RESULTS: In the progression from normal anal epithelium through AIN to SCC, there was increasing expression of MCM2 and MCM5, including in the superficial epithelial third, the source of the majority of cells collected by anal swab.
  • By immunocytochemistry using a mixture of anti-MCM2 and anti-MCM5 antibodies, immunopositive cells were readily identified in anal cytology samples, even at low magnification.
  • CONCLUSIONS: MCMs are promising biomarkers for improving detection of AIN and SCC in anal cytology samples.

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18843031.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] ENG
  • [Grant] United Kingdom / Medical Research Council / / MC/ U105359875; United Kingdom / Medical Research Council / / MC/ U105359878; United Kingdom / Cancer Research UK / / ; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Ki-67 Antigen; 0 / MCM5 protein, human; 0 / Nuclear Proteins; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
  •  go-up   go-down


36. Mahto M, Nathan M, O'Mahony C: More than a decade on: review of the use of imiquimod in lower anogenital intraepithelial neoplasia. Int J STD AIDS; 2010 Jan;21(1):8-16
PubMed Health. DARE review .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] More than a decade on: review of the use of imiquimod in lower anogenital intraepithelial neoplasia.
  • To assess the effectiveness of 5% imiquimod cream (IQ) in the treatment of vulvar, penile and anal intraepithelial neoplasias (VIN, PIN and AIN), we searched Medline, Embase, PubMed and Cochrane Library databases.
  • Use of IQ in PIN and AIN were only supported by cohort studies (two each for PIN and AIN) and case reports (15 for PIN and 3 for AIN).
  • On pooled analysis of RCTs, uncontrolled and cohort studies, the mean complete response (CR) rate for VIN, PIN and AIN were 51%, 70% and 48%, respectively.
  • The mean partial response (PR) rate for VIN, PIN and AIN were 25%, 30% and 34% respectively.
  • The recurrence (RR) rate for VIN, PIN and AIN were 16%, 0% and 36%, respectively.
  • The follow-up period for VIN, PIN and AIN ranged from 2 to 32 months, 10 to 12 months and 11 to 39 months, respectively.
  • Although the results for PIN look the best, the strongest evidence regarding efficacy of IQ in anogenital intraepithelial neoplasia is for VIN supported by RCTs.
  • Evidence for use of IQ in AIN was essentially limited to HIV-positive men who have sex with men.
  • [MeSH-major] Adjuvants, Immunologic / therapeutic use. Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. Penile Neoplasms / drug therapy. Vulvar Neoplasms / drug therapy

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • MedlinePlus Health Information. consumer health - Vulvar Cancer.
  • Hazardous Substances Data Bank. Imiquimod .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20029061.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
  • [Number-of-references] 69
  •  go-up   go-down


37. Mullerat J, Perrett CW, Deroide F, Winslet MC, Bofill M, Poulters LW: The role of macrophages in angiogenesis. Comparison between HIV+ and HIV- populations with anal dysplasia and anal cancer. Anticancer Res; 2005 Mar-Apr;25(2A):693-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of macrophages in angiogenesis. Comparison between HIV+ and HIV- populations with anal dysplasia and anal cancer.
  • BACKGROUND: While macrophages (CD68+) have been associated with angiogenesis in some inflammatory and neoplastic processes by increasing the release of vascular endothelial growth factor (VEGF), their role in anal intraepithelial neoplasia (AIN) and anal squamous cell carcinoma has not been established.
  • This study records macrophage infiltration in anal pre-invasive and invasive lesions in HIV+ and HIV- populations, and determines their relationship with angiogenesis.
  • MATERIALS AND METHODS: Sixty patients (31 HIV+) with AIN and anal SCC were studied.
  • [MeSH-major] Anus Neoplasms / blood supply. Anus Neoplasms / virology. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / virology. HIV Infections / pathology. Macrophages / physiology. Neovascularization, Pathologic / virology
  • [MeSH-minor] Anal Canal / blood supply. Anal Canal / pathology. Antigens, CD / biosynthesis. Antigens, Differentiation, Myelomonocytic / biosynthesis. Anus Diseases / pathology. Anus Diseases / virology. Disease Progression. Humans. Immunohistochemistry. Precancerous Conditions / blood supply. Precancerous Conditions / virology. Vascular Endothelial Growth Factor A / biosynthesis. Warts / pathology. Warts / virology

  • Genetic Alliance. consumer health - Anal Cancer.
  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15868898.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Vascular Endothelial Growth Factor A
  •  go-up   go-down


38. Siekas LL, Aboulafia DM: Establishing an anal dysplasia clinic for HIV-infected men: initial experience. AIDS Read; 2009 May;19(5):178-86
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishing an anal dysplasia clinic for HIV-infected men: initial experience.
  • Anal dysplasia caused by human papillomavirus (HPV) infection is common in the HIV-infected population and is a precursor to squamous cell carcinoma of the anus (SCCA).
  • Herein, we describe our initial experience in assessing the frequency and severity of anal intraepithelial neoplasia (AIN) in a newly formed anal dysplasia clinic in Seattle.
  • Forty-seven patients of the 122 patients who underwent biopsy (39%) had biopsy-identified low-grade AIN, and 47 (39%) had high-grade AIN (HGAIN).
  • Patient tolerance and acceptance of AIN screening was good, and the majority of those who underwent screening have been adherent to recommended follow-up examinations and treatment.
  • We anticipate that the anal dysplasia clinic will enable our institution to participate in emerging HIV- and HPV-related AIN clinical trials.
  • [MeSH-major] Anus Neoplasms / etiology. Carcinoma in Situ / etiology. Carcinoma, Squamous Cell / etiology. HIV Infections / epidemiology. Precancerous Conditions / etiology

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] AIDS Read. 2009 May;19(5):182-3 [19554737.001]
  • (PMID = 19554736.001).
  • [ISSN] 1053-0894
  • [Journal-full-title] The AIDS reader
  • [ISO-abbreviation] AIDS Read
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


39. Patel HS, Silver AR, Northover JM: Anal cancer in renal transplant patients. Int J Colorectal Dis; 2007 Jan;22(1):1-5
MedlinePlus Health Information. consumer health - Kidney Transplantation.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal cancer in renal transplant patients.
  • PURPOSE: A comprehensive literature review was performed to examine the prevalence of anal cancer, anal intraepithelial neoplasia (AIN) and anal human papillomavirus (HPV) infection in renal transplant recipients who are at risk of anal cancer due to iatrogenic immunosuppression.
  • METHODS: Pertinent articles were identified from searches performed on the National Center for Biotechnology Information database using the following keywords: anal cancer, AIN, screening, renal transplant (or kidney transplant), organ transplant recipients and post-transplant malignancies.
  • RESULTS: The prevalence of AIN is 20% in renal transplant patients.
  • The prevalence of anal HPV infection in established transplant patients is 47%, and the prevalence of anal HPV infection in new transplant patients is 23%.
  • The relative risk for anal cancer in renal transplant patients is 10.
  • CONCLUSIONS: As compared to HIV-positive male patients who practise anal intercourse, renal transplant patients showed a modest rise in relative risk for anal cancer.
  • Screening programmes to detect AIN in HIV-positive patients who practise anal intercourse have been introduced on a preliminary basis in sexual health clinics in the US and may become standard practise in this population.
  • The case for screening in renal transplant patients is unclear and would merit further investigation, especially with reference to the prevalence of anal HPV infection in this population.
  • It may transpire that renal transplant patients would benefit more from HPV prophylaxis rather than screening for AIN.
  • [MeSH-major] Anus Neoplasms / etiology. Carcinoma in Situ / etiology. Graft Rejection / prevention & control. Immunosuppression / adverse effects. Immunosuppressive Agents / adverse effects. Kidney Failure, Chronic / surgery. Kidney Transplantation
  • [MeSH-minor] Anus Diseases / epidemiology. Anus Diseases / virology. Humans. Papillomavirus Infections / epidemiology. Papillomavirus Infections / etiology. Prevalence. Risk Factors

  • Genetic Alliance. consumer health - Kidney cancer.
  • Genetic Alliance. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Kidney Failure.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16133005.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  • [Number-of-references] 29
  •  go-up   go-down


40. Palefsky JM, Berry JM, Jay N, Krogstad M, Da Costa M, Darragh TM, Lee JY: A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals. AIDS; 2006 May 12;20(8):1151-5
SciCrunch. DrugBank: Data: Chemical .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals.
  • OBJECTIVES: To test a therapeutic vaccine consisting of a fusion of the human papillomavirus (HPV) 16 E7 protein and the Mycobacterium bovis heat shock protein 65 (SGN-00101) to treat high-grade anal intraepithelial neoplasia (HG-AIN) in HIV-positive individuals.
  • Anal disease was assessed at baseline, 8, 12, 24 and 48 weeks and was classified as the more severe of anal cytology and anal biopsy.
  • Anal HPV DNA was detected using L1 consensus primer-based PCR followed by type-specific probing and dot-blot hybridization (DBH).
  • PARTICIPANTS: Thirteen HIV-positive men and two HIV-positive women with HG-AIN.
  • At 48 weeks, two of five participants in both the 100 and 500 microg cohorts regressed to AIN 1 and one of five participants in the 1000 microg cohort regressed to atypical squamous cells of undetermined significance (ASC-US).
  • Three of five (60%) participants who regressed to AIN 1 or ASC-US became HPV-negative using DBH and real-time PCR, compared with none of 10 participants with no clinical response (P = 0.02).
  • [MeSH-major] Anus Neoplasms / therapy. Cancer Vaccines / therapeutic use. Carcinoma in Situ / therapy. HIV Seropositivity / complications

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • COS Scholar Universe. author profiles.
  • HIV InSite. treatment guidelines - HIV InSite .
  • HIV InSite. treatment guidelines - Human Herpesvirus-8 .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16691066.001).
  • [ISSN] 0269-9370
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR 00079; United States / NCI NIH HHS / CA / U01 CA 70019; United States / NCI NIH HHS / CA / U01 CA 70047
  • [Publication-type] Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Cancer Vaccines; 0 / Chaperonin 60; 0 / Papillomavirus E7 Proteins; 0 / Recombinant Fusion Proteins; 0 / Viral Vaccines; 0 / heat-shock protein 65, Mycobacterium; EC 3.6.1.- / Chaperonins
  •  go-up   go-down


41. Park IU, Ogilvie JW Jr, Anderson KE, Li ZZ, Darrah L, Madoff R, Downs L Jr: Anal human papillomavirus infection and abnormal anal cytology in women with genital neoplasia. Gynecol Oncol; 2009 Sep;114(3):399-403
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal human papillomavirus infection and abnormal anal cytology in women with genital neoplasia.
  • OBJECTIVES: Describe the type-specific prevalence of anal HPV infection in women with lower genital tract intraepithelial neoplasia and cancer.
  • Describe the prevalence of abnormal anal cytology and identify risk factors for anal HPV infection and abnormal anal cytology in this population.
  • METHODS: We performed a cross-sectional study of women attending 2 university-based colposcopy clinics with high-grade lower genital tract intraepithelial neoplasia or cancer.
  • Participants received anal HPV testing/typing, anal cytology and completed a questionnaire detailing medical history and sexual behavior.
  • RESULTS: Of the 102 women enrolled, 92 (90%) had adequate beta-globin for analysis of HPV DNA status, and 47/92 women (51%) had detectable anal HPV.
  • Overall, 9 women (9%) had abnormal anal cytology, and 7 of those had corresponding anal intraepithelial neoplasia grade I (AIN I).
  • Women with vulvar disease had the highest proportion of abnormal anal cytology (21%) compared to women with cervical disease alone (7%), but this difference was not statistically significant (p=0.10).
  • Neither anal HPV infection nor abnormal cytology was significantly associated with anal sex practices, smoking or number of sexual partners.
  • CONCLUSIONS: Anal infection with high-risk HPV types is common in women with high-grade genital neoplasia, but was not associated with known risk factors for genital HPV infection.
  • Other unidentified risk factors may play a role in the anal HPV infection in this population.
  • Abnormal anal cytology was rare and larger studies are needed to identify risk factors associated with abnormal cytology and anal intraepithelial neoplasia in this population.
  • [MeSH-major] Anus Diseases / virology. Cervical Intraepithelial Neoplasia / virology. Genital Neoplasms, Female / pathology. Papillomavirus Infections / pathology

  • MedlinePlus Health Information. consumer health - Anal Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19501896.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


42. Kruijt B, van der Snoek EM, Sterenborg HJ, Amelink A, Robinson DJ: A dedicated applicator for light delivery and monitoring of PDT of intra-anal intraepithelial neoplasia. Photodiagnosis Photodyn Ther; 2010 Mar;7(1):3-9
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A dedicated applicator for light delivery and monitoring of PDT of intra-anal intraepithelial neoplasia.
  • The objective of this study was to develop an applicator for delivery of light and monitoring of photodynamic therapy (PDT) in the anal cavity for treatment of anal intraepithelial neoplasia grade III (AIN III), which can progress to invasive anal cancer.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / drug therapy. Carcinoma in Situ / diagnosis. Carcinoma in Situ / drug therapy. Lighting / instrumentation. Photochemotherapy / instrumentation. Photosensitizing Agents / administration & dosage

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20230986.001).
  • [ISSN] 1873-1597
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Photosensitizing Agents
  •  go-up   go-down


43. Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, Su D, Sano M, Lytwyn A, Chapman W, Mahony J: Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology. Cancer Epidemiol Biomarkers Prev; 2009 Jul;18(7):1986-92
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology.
  • BACKGROUND: HIV-positive men with a history of anal-receptive intercourse are at risk for anal cancer.
  • We determined whether human papilloma virus (HPV) biomarkers were correlated with anal pathology in these men.
  • The number of HPV genotypes per anal swab was higher for anal intraepithelial neoplasia (AIN) 2/3 than for normal or AIN 1 histology [median, 5 types (interquartile range) (IQR), 3-7 versus 3.5 (IQR), 2-6; P = 0.0005].
  • HPV 16 viral load was also associated with AIN 2/3 histology.
  • CONCLUSIONS: The presence of high-grade anal pathology (AIN 2/3) in HIV-positive men was associated with multiple HPV genotypes, HPV genotypes 16 and 31, and HPV 16 viral load.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Neoplasms / epidemiology. Carcinoma in Situ / epidemiology. Genes, p16. HIV Seropositivity / virology. Oncogene Proteins, Viral / genetics. Repressor Proteins / genetics

  • Genetic Alliance. consumer health - Anal Cancer.
  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19567510.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / E6 protein, Human papillomavirus type 16; 0 / Oncogene Proteins, Viral; 0 / Repressor Proteins
  •  go-up   go-down


44. Walts AE, Thomas P, Bose S: Anal cytology: is there a role for reflex HPV DNA testing? Diagn Cytopathol; 2005 Sep;33(3):152-6
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal cytology: is there a role for reflex HPV DNA testing?
  • There is an increased incidence of anal squamous carcinoma and its precursor lesions (anal intraepithelial neoplasia [AIN]) among persons who engage in anal-receptive sex.
  • Analogous to cervical cancer screening, anal Papanicplaou (Pap) smears currently are used to screen these high-risk populations.
  • Human papilloma virus (HPV) has been implicated in anal carcinoma pathogenesis and this study was performed to assess the potential role of HPV DNA testing as an adjunct to anal cytology.
  • We correlated cytological diagnoses and HPV DNA (Digene Hybrid Capture [HC II] assay) in anal specimens collected in SurePath liquid medium from 118 patients; 54.8% of cases diagnosed as atypical squamous cells of undetermined significance (ASC-US) and 87.8% diagnosed as low-grade squamous intraepithelial lesion (LSIL) or above tested positive for high- risk HPV DNA (B+).
  • Although a cytological diagnosis of ASC-US or above was a reliable indicator for AIN, cytology frequently did not accurately predict the grade of SIL in subsequent biopsy.
  • [MeSH-major] Anal Canal / virology. Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Carcinoma, Squamous Cell / diagnosis. Papillomavirus Infections / diagnosis. Tumor Virus Infections / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078257.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Viral
  •  go-up   go-down


45. Wiley DJ, Huh J, Rao JY, Chang C, Goetz M, Poulter M, Masongsong E, Chang CI, Bernard HU: Methylation of human papillomavirus genomes in cells of anal epithelia of HIV-infected men. J Acquir Immune Defic Syndr; 2005 Jun 1;39(2):143-51
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Methylation of human papillomavirus genomes in cells of anal epithelia of HIV-infected men.
  • Intra-anal malignancies disproportionately affect individuals who engage in anal intercourse because of infection with human papillomaviruses (HPVs), with an increased risk attributed to infection with HIV because of a declining immunity against HPvs. Long-term persistence of HPVs suggests yet other mechanisms that determine the clinical outcome, however.
  • Because methylation of HPV DNA represses oncogene expression in cervical samples, we investigated whether this mechanism also occurs in HIV-positive men and studied the methylation of CpG dinucleotides overlapping with the HPV-16 enhancer and promoter in 16 anal samples.
  • In low-grade anal intraepithelial neoplasia (AIN), methylation was high in CpGs overlapping the viral enhancer but rare in promoter positions, whereas methylation was high in promoter regions in high-grade AIN, especially in samples with a high load of viral genomes.
  • We also detected de novo methylation at methylated (me) CpA, meCpT, and meCpC dinucleotides.
  • Our study expands the observation and mapping of HPV DNA methylation to anal infections and the HIV-positive patient population.
  • [MeSH-minor] Anal Canal / virology. Base Sequence. Biopsy. DNA Primers. DNA, Viral / genetics. DNA, Viral / isolation & purification. Dinucleoside Phosphates / analysis. Enhancer Elements, Genetic. Homosexuality, Male. Humans. Male. Polymerase Chain Reaction. Virus Latency. Virus Replication

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15905729.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-91964; United States / NCI NIH HHS / CA / R01 CA-91964
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA, Viral; 0 / Dinucleoside Phosphates; 2382-65-2 / cytidylyl-3'-5'-guanosine
  •  go-up   go-down


46. Cranston RD, Hirschowitz SL, Cortina G, Moe AA: A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men. Int J STD AIDS; 2008 Feb;19(2):118-20
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men.
  • HIV-positive men who have sex with men (MSM) are at high risk of developing human papillomavirus-associated anal squamous cell cancer.
  • Similar to the management of cervical dysplasia, clinicians are treating high-grade anal dysplasia to prevent progression to cancer.
  • Infrared coagulation (IRC) is an outpatient treatment for high-grade anal dysplasia.
  • This retrospective clinical study reports on 68 HIV-positive MSM with 78 biopsy proven high-grade anal lesions.
  • Of the 74 evaluable lesions; 39 had anal intraepithelial neoplasia (AIN) 1, 20 had AIN 2, seven had AIN 3, and eight had normal epithelium.
  • The IRC showed 64% efficacy per treated lesion and shows promise as a treatment modality for high-grade anal dysplasia in this population.
  • [MeSH-major] Anus Diseases / pathology. Anus Diseases / radiotherapy. Anus Neoplasms / prevention & control. HIV Infections / complications. HIV Seropositivity / complications. Homosexuality, Male. Infrared Rays / therapeutic use

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Anal Disorders.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18334066.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  •  go-up   go-down


47. Salit IE, Lytwyn A, Raboud J, Sano M, Chong S, Diong C, Chapman W, Mahony JB, Tinmouth J: The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening. AIDS; 2010 Jun 1;24(9):1307-13
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening.
  • OBJECTIVE: To assess anal oncogenic human papillomavirus (HPV) and anal cytology as screening tests for detecting high-grade anal intraepithelial neoplasia (AIN 2+), as this is an immediate anal cancer precursor.
  • The endpoint was histologically confirmed AIN 2+ obtained by high-resolution anoscopy.
  • METHODS: We did concomitant anal cytology, anal HPV testing and HRA with directed biopsies without knowing the results of each intervention.
  • The main outcome measures were the sensitivity, specificity, negative predictive value and positive predictive value of anal cytology and oncogenic HPV for the detection of AIN 2+.
  • RESULTS: Cytology was abnormal in 67% of patients: high-grade squamous intraepithelial lesion, 12%; low-grade squamous intraepithelial lesion, 43% and atypical squamous cells of undetermined significance, 12%.
  • Biopsies were abnormal in 68% of patients: AIN 2+, 25% and AIN 1, 43%.
  • Test performance characteristics for the detection of AIN 2+ using any abnormality on anal cytology were: sensitivity 84%, specificity 39%, negative predictive value 88% and positive predictive value 31%; using oncogenic HPV: sensitivity 100%, specificity 16%, negative predictive value 100% and positive predictive value 28%.
  • CONCLUSION: Anal cytology and HPV detection have high sensitivity but low specificity for detecting AIN 2+.
  • HIV-positive men who have sex with men have a high prevalence of AIN 2+ and require high-resolution anoscopy for optimal detection of high-grade anal dysplasia.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Cytodiagnosis / methods. Papillomavirus Infections / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Anal Canal / cytology. Anal Canal / pathology. Biopsy. Cross-Sectional Studies. Early Detection of Cancer. Homosexuality, Male. Humans. Male. Middle Aged. Sensitivity and Specificity. Sexual Behavior. Specimen Handling

  • Genetic Alliance. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20442633.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  •  go-up   go-down


48. Nathan M, Hickey N, Mayuranathan L, Vowler SL, Singh N: Treatment of anal human papillomavirus-associated disease: a long term outcome study. Int J STD AIDS; 2008 Jul;19(7):445-9
MedlinePlus Health Information. consumer health - Warts.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of anal human papillomavirus-associated disease: a long term outcome study.
  • Treatment for human papillomavirus (HPV)-associated anal canal disease has been unsatisfactory.
  • The objective of our study was to determine the treatment outcome in our cohort with anal HPV disease.
  • Eighty-eight patients (48.6%) with high-grade anal intraepithelial neoplasia (AIN) and 82 patients (45.3%) with low-grade AIN underwent treatment.
  • Contrary to the current view that treatment of HPV-related anal disease is difficult, unrewarding due to recurrences and may lead to substantial morbidity, we demonstrate that effective treatment is possible for both low- and high-grade AIN.
  • These findings should help with the general desire to introduce screening for AIN for at-risk groups.
  • [MeSH-major] Anus Diseases / therapy. Anus Neoplasms / therapy. Carcinoma, Squamous Cell / therapy. Laser Therapy / utilization. Papillomavirus Infections / therapy. Warts / therapy

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Anal Disorders.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18574114.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


49. Bean SM, Chhieng DC, Roberson J, Raper JL, Broker TR, Hoesley CJ, Eltoum IA, Jin G: Anal-rectal cytology: correlation with human papillomavirus status and biopsy diagnoses in a population of HIV-positive patients. J Low Genit Tract Dis; 2010 Apr;14(2):90-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal-rectal cytology: correlation with human papillomavirus status and biopsy diagnoses in a population of HIV-positive patients.
  • OBJECTIVES: We describe the cytological distribution of disease, correlate cytological diagnoses with human papillomavirus (HPV) DNA status and surgical biopsy diagnoses, determine if CD4 counts correlate with lesion severity, and compare anal-rectal data of HIV-infected patients (primarily men) with cervical data.
  • MATERIALS AND METHODS: A retrospective search of the computerized database identified 118 HIV-positive patients who had anal-rectal cytology.
  • Cytology results were compared with available follow-up data including repeat anal-rectal cytology tests, surgical biopsy, CD4 counts, and HPV DNA polymerase chain reaction-based genotyping.
  • RESULTS: Cytological diagnoses included 3% unsatisfactory for diagnosis, 41% negative for intraepithelial lesion or malignancy (NILM), 23% atypical squamous cells of undermined significance (ASC-US), 31% low-grade squamous intraepithelial lesion (LSIL), and 2% high-grade squamous intraepithelial lesion (HSIL) (ASC-US/squamous intraepithelial lesion, 0.7:1).
  • Two anal intraepithelial neoplasia (AIN) II, 10 AIN III, and 1 invasive squamous cell carcinoma were histologically detected (11%).
  • The majority of AIN II was preceded by LSIL, 54%; ASC-US, 15%; and HSIL, 8%.
  • CONCLUSIONS: Anal-rectal cytology is a useful screening test.
  • A high percentage of AIN II lesions were detected in this at-risk population, and the majority was detected following cytological abnormality.
  • [MeSH-major] Anal Canal / pathology. HIV Infections / complications. Papillomaviridae / isolation & purification. Papillomavirus Infections / epidemiology. Rectal Neoplasms / epidemiology. Rectum / pathology

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • MedlinePlus Health Information. consumer health - HIV/AIDS in Women.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20354415.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA83679
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  •  go-up   go-down


50. Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Swoboda J, Stücker M, Schmitt M, Pfister H, Wieland U, German Competence Network HIV/AIDS: Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. Br J Dermatol; 2010 Jun;162(6):1269-77
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM).
  • There is a paucity of data published on the progression of high-grade AIN to invasive cancer as well as on clinical and virological characteristics comparing anal margin and anal canal carcinoma.
  • OBJECTIVES: To search for anal carcinoma and AIN in a large series of HIV-positive MSM, to assess treatment response of anal carcinoma, and to analyse lesional HPV spectrum of anal cancers.
  • METHODS: Detection of anal carcinoma and AIN was performed using cytology, high-resolution anoscopy, and histology in case of abnormal findings.
  • Additionally, HPV analyses for 36 high- and low-risk α-HPV types were performed in patients with anal carcinoma.
  • Of these, 116 (26·0%) patients had normal findings, 163 (36·5%) had low-grade AIN, 156 (35·0%) had high-grade AIN, and 11 (2·5%) had anal carcinoma as evidenced by the highest grade of cytology/histology.
  • Five patients with anal cancer, who had refused treatment of their precancerous lesions, had progressed from high-grade AIN to invasive cancer within a median time of 8·6 months.
  • All anal cancers carried high-risk α-HPV types.
  • All five squamous cell carcinomas (SCCs) of the anal canal were HPV16 positive.
  • In contrast, only one of the four anal margin SCCs were HPV16 positive (HPV31, HPV33 and HPV33 + HPV68 were found in the other three anal margin SCCs).
  • In contrast to the cancer biopsies, a broad spectrum of surface high- and low-risk HPV types was found in anal swabs of the patients.
  • Surgical excision resulted in long-term disease control of all anal margin carcinomas, whereas combined chemoradiotherapy in carcinomas of the anal canal was associated with high recurrence rates, high toxicity, and high mortality.
  • CONCLUSIONS: Anal carcinoma and AIN are frequent in HIV-positive men, even in patients participating in anal cancer prevention programmes.
  • High-grade dysplasia in these patients can progress to invasive cancer within a short period of time.
  • Anal margin carcinoma and anal canal carcinoma differ substantially in their lesional HPV spectrum, prognosis and treatment response.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. HIV Seropositivity / complications. Papillomaviridae / isolation & purification

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists.
  • (PMID = 20184584.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00365729
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  •  go-up   go-down


51. De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S: Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int J Cancer; 2009 Apr 1;124(7):1626-36
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis.
  • This meta-analysis investigated human papillomavirus (HPV) prevalence in vulvar, vaginal and anal intraepithelial neoplasia (VIN, VAIN, AIN) grades 1-3 and carcinoma from 93 studies conducted in 4 continents and using PCR assays.
  • Overall HPV prevalence was 67.8%, 85.3% and 40.4% among 90 VIN1, 1,061 VIN2/3 and 1,873 vulvar carcinomas; 100%, 90.1% and 69.9% among 107 VAIN1, 191 VAIN2/3 and 136 vaginal carcinomas; and 91.5%, 93.9% and 84.3% among 671 AIN1, 609 AIN2/3 and 955 anal carcinomas, respectively.
  • HPV16 was found more frequently (>75%) and HPV18 less frequently (<10%) in HPV-positive vulvar, vaginal and anal carcinomas than in cervical carcinoma.
  • HPV prevalence in anal carcinoma was higher among women (90.8%) than men (74.9%), but no difference by gender emerged in North America.
  • In conclusion, approximately 40% of vulvar, 60% of vaginal and 80% of anal carcinoma may be avoided by prophylactic vaccines against HPV16/18.
  • This proportion would be similar for the corresponding high-grade lesions of the vagina and anus, but higher for VIN2/3 (75%) than for vulvar carcinoma.
  • [MeSH-major] Anus Neoplasms / virology. Papillomavirus Infections / epidemiology. Vaginal Neoplasms / virology. Vulvar Neoplasms / virology

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Vaginal Cancer.
  • MedlinePlus Health Information. consumer health - Vulvar Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19115209.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


52. Oon SF, Hanly A, Winter DC: Pap smears for men: a vision of the future? Ir J Med Sci; 2010 Sep;179(3):459-62
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN) rarely receives as much publicity as its neighbouring orifice, the cervix.
  • As in the cervix, intraepithelial neoplasias are precursors to cancer in the anal canal.
  • AIN and cervical interstitial neoplasia (CIN) undergo dysplasia as a consequence of human papillomavirus (HPV) infection.
  • Anal cancer, however, has been rising, with a predilection for human immunodeficiency virus-infected men.
  • HPV causes a squamous epithelial dysplasia and converts healthy tissue into AINs of increasing severity until anal cancer manifests.
  • CONCLUSIONS: The paper concludes by briefly discussing the implications of a national screening programme against AIN in the future.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology
  • [MeSH-minor] Adult. Anus Diseases / surgery. Anus Diseases / therapy. Anus Diseases / virology. Cervical Intraepithelial Neoplasia / virology. Condylomata Acuminata / surgery. Condylomata Acuminata / therapy. Condylomata Acuminata / virology. Cytodiagnosis. Female. Humans. Male. Papillomavirus Infections. Recurrence. Uterine Cervical Neoplasms / virology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Ir J Med Sci. 2010 Jun;179(2):319 [19921312.001]
  • (PMID = 19763675.001).
  • [ISSN] 1863-4362
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


53. Czoski-Murray C, Karnon J, Jones R, Smith K, Kinghorn G: Cost-effectiveness of screening high-risk HIV-positive men who have sex with men (MSM) and HIV-positive women for anal cancer. Health Technol Assess; 2010 Nov;14(53):iii-iv, ix-x, 1-101
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cost-effectiveness of screening high-risk HIV-positive men who have sex with men (MSM) and HIV-positive women for anal cancer.
  • BACKGROUND: Anal cancer is uncommon and predominantly a disease of the elderly.
  • Individuals who are human immunodeficiency virus (HIV)-positive are particularly vulnerable to HPV infections, and increasing numbers from this population present with anal cancer.
  • OBJECTIVE: To estimate the cost-effectiveness of screening for anal cancer in the high-risk HIV-positive population [in particular, men who have sex with men (MSM), who have been identified as being at greater risk of the disease] by developing a model that incorporates the national screening guidelines criteria.
  • Papers that met the inclusion criteria contained the following: data on population incidence, effectiveness of screening, health outcomes or screening and/or treatment costs; defined suitable screening technologies; prospectively evaluated tests to detect anal cancer.
  • RESULTS: The reference case cost-effectiveness model for MSM found that screening for anal cancer is very unlikely to be cost-effective.
  • The negative aspects of screening included utility decrements associated with false-positive results and with treatment for high-grade anal intraepithelial neoplasia (HG-AIN).
  • However, combined with higher regression rates from low-grade anal intraepithelial neoplasia (LG-AIN), the lowest expected incremental cost-effectiveness ratio remained at over 44,000 pounds per quality-adjusted life-year (QALY) gained.
  • LIMITATIONS: Limited knowledge is available about the epidemiology and natural history of anal cancer, along with a paucity of good-quality evidence concerning the effectiveness of screening.
  • Further studies could assess whether the screening model has underestimated the impact of anal cancer, the results of which may justify an evaluative study of the effects of treatment for HG-AIN.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / economics. HIV Infections / complications. Homosexuality, Male / statistics & numerical data. Mass Screening / economics


54. Kreuter A, Brockmeyer NH, Wieland U: [Anal intraepithelial neoplasia and anal carcinoma: an increasing problem in HIV patients]. Hautarzt; 2010 Jan;61(1):21-6
MedlinePlus Health Information. consumer health - HIV/AIDS in Women.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia and anal carcinoma: an increasing problem in HIV patients].
  • [Transliterated title] Anale intraepitheliale Neoplasie und Analkarzinom : Ein zunehmendes Problem bei Menschen mit HIV-Infektion.
  • Anal dysplasia is common in HIV patients, especially in HIV-positive men having sex with men (MSM).
  • High-grade anal dysplasia can progress to invasive anal cancer.
  • As in cervical carcinoma, there is a cause and effect relationship between anal cancer and human papillomavirus (HPV) infection, especially with high-risk types such as HPV16.
  • Several experts have recommended screening programs for anal cancer, including anal cytology along the lines of the Pap smear in women.
  • Clinical inspection, lesion biopsy, and treatment of anal dysplasia are performed under high-resolution anoscopy.
  • Anal cancer is divided into cancer of the anal margin and cancer of the anal canal.
  • Early cancer of the anal margin is excised akin to squamous cell cancer of the exposed skin, whereas cancer of the anal canal is treated by radiochemotherapy.
  • Physicians working in the field of HIV/AIDS should regularly screen their patients for the presence of anal dysplasia and anal cancer.
  • Basic diagnostic workup includes clinical inspection of the perianal area, digital rectal examination, and anal cytology.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / prevention & control. Carcinoma in Situ / virology. HIV Infections / complications. Precancerous Conditions / diagnosis. Precancerous Conditions / prevention & control

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - HIV/AIDS.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19967333.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


55. van der Snoek EM, van der Ende ME, Schouten WR, den Hollander JC, van der Meijden WI: [Anorectal malignancies and dysplasia in HIV-positive men who have sex with men]. Ned Tijdschr Geneeskd; 2005 Sep 3;149(36):1989-93
MedlinePlus Health Information. consumer health - HIV/AIDS.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anorectal malignancies and dysplasia in HIV-positive men who have sex with men].
  • Persistent human papillomavirus (HPV) infection is a major risk factor for the development of anal (pre)malignancies.
  • Less is known about the natural history of anal intraepithelial neoplasia (AIN).
  • Screening in HIV-positive and HIV-negative MSM for anorectal malignancies or dysplasia is cost-effective if the incidence is sufficiently high.
  • Treatment options range from watchful waiting for asymptomatic grade-1 AIN to excision or radio(chemo)therapy for anorectal carcinoma.
  • [MeSH-major] Anus Neoplasms / epidemiology. HIV Infections / complications. Homosexuality, Male. Precancerous Conditions / epidemiology. Rectal Neoplasms / epidemiology

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16171110.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
  •  go-up   go-down


56. Membrilla-Fernández E, Parés D, Alameda F, Pascual M, Courtier R, Gil MJ, Vallecillo G, Fusté P, Pera M, Grande L: [Anal intraepithelial neoplasia: application of a diagnostic protocol in risk patients using anal cytology]. Cir Esp; 2009 Jun;85(6):365-70
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia: application of a diagnostic protocol in risk patients using anal cytology].
  • [Transliterated title] Neoplasia intraepitelial anal: resultados de la aplicación de un protocolo diagnóstico en pacientes de riesgo mediante el uso de citología anal.
  • INTRODUCTION: Anal intraepithelial neoplasia is a precursor condition of squamous anal carcinoma.
  • The groups at risk of this lesion are patients with anogenital condylomata, cervical dysplasia, human immunodeficiency virus infection and, in general, patients with HPV infection.
  • The aim of this study was to analyse the results of a diagnostics protocol of Anal Intraepithelial Neoplasia in high risk population using anal cytology.
  • PATIENTS AND METHOD: The protocol is based on a visit in the outpatient department, clinical interview, physical examination and anal cytology evaluated by Bethesda criteria.
  • The cross-sectional observational study was designed to study the anal smear results and their relationship with risk factors.
  • In the overall series, 25 patients have been diagnosed with abnormal anal cytology: 9 atypical squamous cells of undetermined significance (ASCUS), 15 low-grade and 1 high-grade squamous intraepithelial lesions.
  • There were no significant associations between abnormal cytology results and the presence of anal condyloma (p = 0.22).
  • CONCLUSIONS: Our diagnostic protocol of anal intraepithelial neoplasia revealed 25% of patients with pre-invasive lesions of squamous anal cancer.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19303590.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


57. Li Y, Yang Z, Chen Z, Zhou Z: Computational investigation on structural and physical properties of AIN nanosheets and nanoribbons. J Nanosci Nanotechnol; 2010 Nov;10(11):7200-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Computational investigation on structural and physical properties of AIN nanosheets and nanoribbons.
  • Through first-principles computations, we investigated the structural, electronic and magnetic properties of two-dimensional AIN single layer and one-dimensional AIN nanoribbons.
  • AIN single layer and nanoribbons quit the Wurtzite configuration and adopt a graphitic-like structure after geometry optimization.
  • Both hydrogen-terminated zigzag and armchair AIN nanoribbons have a direct band gap, which increases monotonically with increasing ribbon width.
  • Bare zigzag AIN nanoribbons have a spin-polarized ground state and are magnetic semiconductors.
  • The results may promote the experimental preparation of AIN nanosheets and nanoribbons and their applications to nanotechnology.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21137897.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


58. Lillo FB: Human papillomavirus infection and its role in the genesis of dysplastic and neoplastic lesions of the squamous epithelia. New Microbiol; 2005 Apr;28(2):111-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus infection and its role in the genesis of dysplastic and neoplastic lesions of the squamous epithelia.
  • Extensive laboratory and epidemiological evidence demonstrate that human papillomavirus (HPV) is the major cause of squamous cervical carcinoma (SCC), its precursor lesions (cervical intraepithelial neoplasia - CIN) and several other benign and malign clinical manifestations including genital warts, condylomata acuminata, Bowenoid papulosis, vaginal, vulvar and anal intraepithelial neoplasia (VIN and AIN) and carcinoma, penile carcinoma and other squamous neoplasias of the head and neck districts.
  • [MeSH-major] Carcinoma, Squamous Cell. Cervical Intraepithelial Neoplasia. Papillomaviridae / pathogenicity. Papillomavirus Infections / virology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16035255.001).
  • [ISSN] 1121-7138
  • [Journal-full-title] The new microbiologica
  • [ISO-abbreviation] New Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 40
  •  go-up   go-down


59. Fox PA: Human papillomavirus and anal intraepithelial neoplasia. Curr Opin Infect Dis; 2006 Feb;19(1):62-6
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus and anal intraepithelial neoplasia.
  • PURPOSE OF REVIEW: A review of recent developments in the understanding of the natural history of anal squamous carcinoma arising from areas of high-grade anal intraepithelial neoplasia.
  • RECENT FINDINGS: Anal intraepithelial neoplasia is a consequence of chronic human papillomavirus infection in the anal canal and appears to be driven by high viral loads of human papillomavirus.
  • Anal intraepithelial neoplasia is equally prevalent in different age groups of men who have sex with men, but in other respects what is known of its natural history resembles that of cervical intraepithelial neoplasia.
  • HIV-positives who practise receptive anal intercourse are at highest risk of anal intraepithelial neoplasia.
  • Screening is easy to perform using cytology; the limitations of anal cytology being similar to those of cervical cytology.
  • [MeSH-major] Anus Neoplasms. Carcinoma in Situ. Carcinoma, Squamous Cell. Papillomaviridae / pathogenicity. Papillomavirus Infections

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16374220.001).
  • [ISSN] 0951-7375
  • [Journal-full-title] Current opinion in infectious diseases
  • [ISO-abbreviation] Curr. Opin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
  •  go-up   go-down


60. Baynouna LM, Revel AD, Nagelkerke NJ, Jaber TM, Omar AO, Ahmed NM, Nazirudeen MK, Al Sayed MF, Nour FA, Abdouni S: Associations of cardiovascular risk factors in Al Ain, United Arab Emirates. Cardiovasc Diabetol; 2009;8:21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Associations of cardiovascular risk factors in Al Ain, United Arab Emirates.
  • METHOD: A community based survey, of conventional risk factors for cardiovascular disease was conducted among 817 national residents of Al Ain city, UAE.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Isr Med Assoc J. 2000 Mar;2(3):207-10 [10774268.001]
  • [Cites] Am J Prev Med. 2008 Oct;35(4):357-63 [18779029.001]
  • [Cites] J Clin Hypertens (Greenwich). 2002 Jan-Feb;4(1):17-22 [11821633.001]
  • [Cites] Diabet Med. 2002 Nov;19(11):954-7 [12421434.001]
  • [Cites] J Epidemiol Community Health. 2003 Sep;57(9):734-9 [12933782.001]
  • [Cites] East Mediterr Health J. 2002 Mar-May;8(2-3):374-85 [15339127.001]
  • [Cites] Nihon Ronen Igakkai Zasshi. 1993 Sep;30(9):778-86 [8230791.001]
  • [Cites] Heart. 1998 Mar;79(3):248-52 [9602657.001]
  • [Cites] Diabetes Care. 2005 Sep;28(9):2289-304 [16123508.001]
  • [Cites] J Hum Hypertens. 2005 Nov;19(11):861-8 [16034449.001]
  • [Cites] Hypertension. 2006 Mar;47(3):403-9 [16432042.001]
  • [Cites] Endocr Pract. 2006 Jan-Feb;12 Suppl 1:20-4 [16627375.001]
  • [Cites] Am J Clin Nutr. 2006 Jun;83(6):1237-47 [16762930.001]
  • [Cites] Medicina (Kaunas). 2006;42(7):559-65 [16861837.001]
  • [Cites] Am J Med. 2006 Oct;119(10):812-9 [17000207.001]
  • [Cites] J Am Coll Cardiol. 2007 Jan 30;49(4):403-14 [17258085.001]
  • [Cites] Diabetes Educ. 2007 Jan-Feb;33(1):69, 74-5, 77-8 [17272794.001]
  • [Cites] Epidemiol Rev. 2007;29:115-28 [17494056.001]
  • [Cites] Diabetes Res Clin Pract. 2007 Dec;78(3):369-77 [17532085.001]
  • [Cites] J Hypertens. 2008 Feb;26(2):169-77 [18192826.001]
  • [Cites] Diabetes Care. 2008 Apr;31(4):732-4 [18235051.001]
  • [Cites] Diabetes Care. 2008 Apr;31(4):684-9 [18252904.001]
  • [Cites] Cerebrovasc Dis. 2008;25(6):539-47 [18480607.001]
  • [Cites] Obesity (Silver Spring). 2008 Jul;16(7):1622-35 [18421260.001]
  • [Cites] Am J Cardiol. 2008 Jul 15;102(2):188-91 [18602519.001]
  • [Cites] Saudi Med J. 2008 Aug;29(8):1173-8 [18690314.001]
  • [Cites] East Mediterr Health J. 2008 May-Jun;14(3):647-53 [18720629.001]
  • [Cites] Am J Med. 2000 Nov;109(7):538-42 [11063954.001]
  • (PMID = 19371412.001).
  • [ISSN] 1475-2840
  • [Journal-full-title] Cardiovascular diabetology
  • [ISO-abbreviation] Cardiovasc Diabetol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2673216
  •  go-up   go-down


61. Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA: The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. Int J STD AIDS; 2007 Feb;18(2):77-80
MedlinePlus Health Information. consumer health - HIV/AIDS.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men.
  • Due to the increasing incidence of anal cancer in HIV-positive men who have sex with men, and the potential to detect and treat high-grade anal dysplasia--the putative anal cancer precursor--we have introduced an anal cytology screening service.
  • Patients with abnormal anal cytology have follow-up high-resolution anoscopy (HRA) with biopsy of lesions clinically suspicious for high-grade dysplasia.
  • One hundred and sixty-four (67%) men had abnormal anal cytology, and 93 of them had follow-up HRA and anal biopsy.
  • The positive predictive value for any anal cytological abnormality to predict any degree of anal dysplasia was 95.7+/-2.1%, and for any anal cytological abnormality to predict high-grade anal dysplasia was 55.9+/-5.1%.
  • Abnormal anal cytology was highly predicative of anal dysplasia on biopsy.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma, Squamous Cell. HIV Infections / complications. Homosexuality, Male
  • [MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / epidemiology. Adult. Aged. Biopsy. Cytological Techniques. Humans. Male. Middle Aged. Predictive Value of Tests. Prevalence

  • Genetic Alliance. consumer health - HIV.
  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17331275.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


62. Byun JS, Lee SS: Effect of soybeans and sword beans on bone metabolism in a rat model of osteoporosis. Ann Nutr Metab; 2010;56(2):106-12
MedlinePlus Health Information. consumer health - Osteoporosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Seven-week-old female Sprague-Dawley rats were raised for 2 weeks on a calcium-free diet based on the American Institute of Nutrition (AIN)-93M diets.

  • MedlinePlus Health Information. consumer health - Bone Density.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20110670.001).
  • [ISSN] 1421-9697
  • [Journal-full-title] Annals of nutrition & metabolism
  • [ISO-abbreviation] Ann. Nutr. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Biomarkers; 0 / Tumor Necrosis Factor-alpha; 104982-03-8 / Osteocalcin; 90032-33-0 / deoxypyridinoline
  •  go-up   go-down


63. Nahas SC, Nahas CS, Silva Filho EV, Levi JE, Atui FC, Marques CF: Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report. Sao Paulo Med J; 2007 Sep 6;125(5):292-4
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report.
  • CONTEXT: Highly active antiretroviral therapy (HAART) has turned human immunodeficiency virus (HIV) infection into a chronic condition, and this has led to increased incidence of anal dysplasia among HIV-positive patients.
  • Routine anal evaluation including the anal canal and perianal area is recommended for this population, especially for patients infected by oncogenic human papillomavirus (HPV) types.
  • CASE REPORT: A 54-year-old homosexual HIV-positive man presented with a six-year history of recurrent perianal and anal warts.
  • He presented some condylomatous spreading lesions occupying part of the anal canal and the perianal skin, and also a well-demarcated slightly painful perianal plaque of dimensions 1.0 x 1.0 cm.
  • Both anal canal Pap smears and biopsies guided by high-resolution anoscopy revealed high-grade squamous intraepithelial lesion.
  • Biopsies of the border of the perianal plaque also revealed high-grade squamous intraepithelial lesion.
  • HPV DNA testing of the anus detected the presence of HPV-16 type.
  • Histological analysis on the excised tissue revealed high-grade squamous intraepithelial lesion with one focus of microinvasive squamous cell cancer measuring 1 mm.
  • The patient showed pathological evidence of recurrent anal and perianal high-grade squamous intraepithelial lesions at the sixth-month follow-up and required further ablation of those lesions.
  • However no invasive squamous cell carcinoma recurrence has been detected so far.
  • [MeSH-major] Antiretroviral Therapy, Highly Active / adverse effects. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. HIV Seropositivity / drug therapy. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections / pathology
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / virology. DNA, Viral / analysis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis


64. Rozmus-Warcholińska W, Loch T, Czuba B, Mazurek U, Mucha J, Dworak D, Sodowski K: [Genital warts associated with HPV infection during II and III trimester of pregnancy--a case report and analysis of treatment options]. Ginekol Pol; 2007 Nov;78(11):888-91
MedlinePlus Health Information. consumer health - Infections and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A visible genital form of HPV infection are genital warts, which are commonly caused by HPV types 6 and 11, and appear on the vulva, cervix, vagina, urethra and anus.
  • Oncogenic HPV types 16, 18, 31, 33 and 35 are also found in genital warts and are associated with vulval (VII), cervical (CIN) and anal (AIN) intraepithelial neoplasia.
  • [MeSH-major] Condylomata Acuminata / diagnosis. Condylomata Acuminata / therapy. Human papillomavirus 6 / isolation & purification. Pregnancy Complications, Infectious / diagnosis. Pregnancy Complications, Infectious / therapy

  • Genetic Alliance. consumer health - Pregnancy.
  • MedlinePlus Health Information. consumer health - Genital Warts.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18306923.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  •  go-up   go-down


65. Al-Naeem AA: Hydrochemical processes and metal composition of Ain Umm-Sabah natural spring in Al-Hassa Oasis Eastern Province, Saudi Arabia. Pak J Biol Sci; 2008 Jan 15;11(2):244-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hydrochemical processes and metal composition of Ain Umm-Sabah natural spring in Al-Hassa Oasis Eastern Province, Saudi Arabia.
  • A total of 10 water samples were collected from Ain Umm Sabah at different times and from different locations from the spring basin.
  • The Ain Umm Sabah water is Na-Cl dominant water and can create soil sodicity problems and cause Na and Cl ion toxicity to plants if used for irrigation of sensitive crops.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18817197.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences : PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Metals
  •  go-up   go-down


66. Fiedler JL, Villalobos CA, De Mattos AC: An activity-based cost analysis of the Honduras community-based, integrated child care (AIN-C) programme. Health Policy Plan; 2008 Nov;23(6):408-27
MedlinePlus Health Information. consumer health - Children's Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An activity-based cost analysis of the Honduras community-based, integrated child care (AIN-C) programme.
  • The Honduras AIN-C programme is a preventive health and nutrition programme of the Honduras Ministry of Health (MOH) that relies on volunteers to help mothers monitor and maintain the adequate growth of young children.
  • This study was undertaken to provide the first comprehensive estimates of the cost of the AIN-C programme, with the goal of providing a programme and financial planning tool for Honduras.
  • An additional comparison of study findings was also undertaken to determine the cost of the AIN-C programme's community-based services relative to a similar facility-based service.
  • (3) the cost of an AIN-C monthly growth monitoring and counselling session per child is 11% of the cost of a traditional MOH, facility-based growth and development consultation per child; and (4) the effect of mothers substituting AIN-C monitor care for MOH facility-based care 'saves' 203 000 outpatient visits a year, with a potential cost saving of $1.66 million, the equivalent of 60% of the recurrent cost of the programme and roughly equal to the annual incremental budget requirements of the programme.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18755734.001).
  • [ISSN] 0268-1080
  • [Journal-full-title] Health policy and planning
  • [ISO-abbreviation] Health Policy Plan
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  •  go-up   go-down


67. Al-Muhairi SS, Zoubeidi TA, Ellis ME, Safa WF, Joseph J: Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates. Saudi Med J; 2006 Jul;27(7):1044-8
MedlinePlus Health Information. consumer health - Pneumonia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates.
  • METHODS: We retrospectively analyze the data collected from all inpatients over the age of 16 years with a diagnosis of pneumonia in Tawam Hospital, Al-Ain, United Arab Emirates between the years 1997 and 2002.
  • [MeSH-major] Pneumonia / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16830028.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  •  go-up   go-down


68. El-Lamie IK, El Sayed HM, Badawie AG, Bayomi WA, El-Ghazaly HA, Khalaf-Allah AE, El-Mahallawy MN, El-Lamie KI: Evolution of treatment of high-risk metastatic gestational trophoblastic tumors: Ain Shams University experience. Int J Gynecol Cancer; 2006 Mar-Apr;16(2):866-74
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolution of treatment of high-risk metastatic gestational trophoblastic tumors: Ain Shams University experience.
  • The aim of the current study is to evaluate the different treatment modalities used in the management of high-risk metastatic gestational trophoblastic tumors (GTT) between June 1992 and December 2004 at the Gynecologic Oncology Unit, Ain Shams University.

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • MedlinePlus Health Information. consumer health - Uterine Cancer.
  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. CHLORAMBUCIL .
  • Hazardous Substances Data Bank. ETOPOSIDE .
  • Hazardous Substances Data Bank. CYCLOPHOSPHAMIDE .
  • Hazardous Substances Data Bank. DACTINOMYCIN .
  • Hazardous Substances Data Bank. VINCRISTINE .
  • Hazardous Substances Data Bank. METHOTREXATE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16681775.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 18D0SL7309 / Chlorambucil; 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate; EMA-CO protocol; MDC protocol; PEA-M regimen
  •  go-up   go-down


69. Abd Elaziz KM, Bakr IM: Assessment of knowledge, attitude and practice of hand washing among health care workers in Ain Shams University hospitals in Cairo. J Prev Med Hyg; 2009 Mar;50(1):19-25
MedlinePlus Health Information. consumer health - Infection Control.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessment of knowledge, attitude and practice of hand washing among health care workers in Ain Shams University hospitals in Cairo.
  • The aim of this work was to assess the knowledge, attitude and practice of hand washing among health care workers (HCW) in Ain-Shams University hospitals and to investigate the presence of the necessary facilities and supplies required for hand washing (HW) in ten wards.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19771756.001).
  • [ISSN] 1121-2233
  • [Journal-full-title] Journal of preventive medicine and hygiene
  • [ISO-abbreviation] J Prev Med Hyg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


70. Duffy PH, Lewis SM, Mayhugh MA, Trotter RW, Hass BS, Latendresse JR, Thorn BT, Tobin G, Feuers RJ: Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes. Nutr Res; 2008 Jan;28(1):36-42
MedlinePlus Health Information. consumer health - Seniors' Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes.
  • The primary purpose of this study was to evaluate the effects of age and long-term dietary reduction on neoplastic diseases in rats fed the AIN-93M purified diet.
  • Male Sprague-Dawley rats assigned to 2 groups, ad libitum (AL) and dietary restricted (DR), were fed the AIN-93M (casein protein) diet free choice and reduced in amount by 31%, respectively.

  • MedlinePlus Health Information. consumer health - Dietary Proteins.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19083386.001).
  • [ISSN] 1879-0739
  • [Journal-full-title] Nutrition research (New York, N.Y.)
  • [ISO-abbreviation] Nutr Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caseins; 0 / Dietary Proteins
  •  go-up   go-down


71. Baynouna LM, Revel AD, Nagelkerke NJ, Jaber TM, Omar AO, Ahmed NM, Naziruldeen MK, Al-Sayed MF, Nour FA: High prevalence of the cardiovascular risk factors in Al-Ain, United Arab Emirates. An emerging health care priority. Saudi Med J; 2008 Aug;29(8):1173-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High prevalence of the cardiovascular risk factors in Al-Ain, United Arab Emirates. An emerging health care priority.
  • METHODS: A cross-sectional community based study on established cardiovascular risk factors carried out between February 2004 - February 2005 in Al-Ain City, UAE.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18690314.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  •  go-up   go-down


72. Bouzidi A, Souahi F, Hanini S: Sorption behavior of cesium on Ain Oussera soil under different physicochemical conditions. J Hazard Mater; 2010 Dec 15;184(1-3):640-6
Hazardous Substances Data Bank. CESIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sorption behavior of cesium on Ain Oussera soil under different physicochemical conditions.
  • In the present study, the sorption behavior of cesium was investigated in Ain Oussera soil around the Es-Salam reactor facility.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20869168.001).
  • [ISSN] 1873-3336
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Soil Pollutants; 1KSV9V4Y4I / Cesium
  •  go-up   go-down


73. Sasaki T, Fujikane Y, Ogino Y, Osada K, Sugano M: Hepatic function and lipid metabolism are modulated by short-term feeding of cholesterol oxidation products in rats. J Oleo Sci; 2010;59(9):503-7
Hazardous Substances Data Bank. CHOLESTEROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The rats (age, 8 weeks) were fed American Institute of Nutrition (AIN)-purified diets containing 0.5% cholesterol or 0.5% COPs for 7 days.

  • MedlinePlus Health Information. consumer health - Cholesterol.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20720381.001).
  • [ISSN] 1347-3352
  • [Journal-full-title] Journal of oleo science
  • [ISO-abbreviation] J Oleo Sci
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cholesterol, Dietary; 0 / Reactive Oxygen Species; 97C5T2UQ7J / Cholesterol
  •  go-up   go-down


74. Al-Hammadi S, Al-Maskari F, Bernsen R: Prevalence of food allergy among children in Al-Ain city, United Arab Emirates. Int Arch Allergy Immunol; 2010;151(4):336-42
MedlinePlus Health Information. consumer health - Food Allergy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence of food allergy among children in Al-Ain city, United Arab Emirates.
  • This cross-sectional study was carried out to assess the prevalence of FA among school children aged 6-9 years in Al-Ain city, UAE.
  • METHODS: We used multistage random sampling in order to get a sample of 397 school children whose parents completed a self-administered questionnaire designed to assess the presence or absence of physician diagnosis of FA and other allergic diseases.
  • CONCLUSIONS: The prevalence of FA in Al-Ain city was 8%.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] 2009 S. Karger AG, Basel.
  • (PMID = 19851075.001).
  • [ISSN] 1423-0097
  • [Journal-full-title] International archives of allergy and immunology
  • [ISO-abbreviation] Int. Arch. Allergy Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Allergens
  •  go-up   go-down


75. Ghazal-Aswad S, Badrinath P, Osman NA, Abdul-Khalik S, Raasclou T: Is there a correlation between vaginal chlamydia infection and cervical smear abnormalities? A community-based study in the Al-Ain district, United Arab Emirates. J Obstet Gynaecol Res; 2006 Feb;32(1):63-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is there a correlation between vaginal chlamydia infection and cervical smear abnormalities? A community-based study in the Al-Ain district, United Arab Emirates.
  • METHODS: In this cross-sectional, community-based survey, women attending primary and secondary care in the Al-Ain medical district, United Arab Emirates, were offered cervical screening using the Papanicolaou smear, and chlamydia testing.
  • Twelve subjects had abnormal smears, including smears showing atypical squamous cells of undetermined significance.
  • [MeSH-major] Chlamydia Infections / epidemiology. Uterine Cervical Dysplasia / epidemiology. Vaginal Diseases / epidemiology

  • Genetic Alliance. consumer health - Chlamydia.
  • MedlinePlus Health Information. consumer health - Chlamydia Infections.
  • MedlinePlus Health Information. consumer health - Vaginal Diseases.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16445527.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  •  go-up   go-down


76. Barnard DE, Lewis SM, Teter BB, Thigpen JE: Open- and closed-formula laboratory animal diets and their importance to research. J Am Assoc Lab Anim Sci; 2009 Nov;48(6):709-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • During the 1970s, the American Institute of Nutrition, National Academy of Science, Institute of Laboratory Animal Resources, and Laboratory Animals Centre Diets Advisory Committee supported the use of 'standard reference diets' in biomedical research as a means to improve the ability to replicate research.
  • [MeSH-major] Animal Feed / standards. Animal Husbandry / standards. Animal Nutrition Sciences / standards. Animals, Laboratory / physiology. Biomedical Research / standards. Food, Formulated / standards

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Contemp Top Lab Anim Sci. 1993 Jan;33(1):26-8 [16468690.001]
  • [Cites] Environ Health Perspect. 2005 Sep;113(9):1120-2 [16140614.001]
  • [Cites] Environ Health Perspect. 2007 Dec;115(12):1717-26 [18087589.001]
  • [Cites] Lab Anim Sci. 1999 Oct;49(5):530-6 [10551455.001]
  • [Cites] Lab Invest. 2001 May;81(5):735-47 [11351045.001]
  • [Cites] Nutrition. 2003 Apr;19(4):342-6 [12679169.001]
  • [Cites] Psychopharmacology (Berl). 2003 Apr;167(1):46-53 [12618915.001]
  • [Cites] Physiol Genomics. 2004 Jan 15;16(2):166-77 [14726599.001]
  • [Cites] Comp Med. 2003 Dec;53(6):607-15 [14727808.001]
  • [Cites] ILAR J. 2004;45(4):401-16 [15454679.001]
  • [Cites] Am J Pathol. 1974 Jan;74(1):95-108 [4809317.001]
  • [Cites] Environ Health Perspect. 1974 Dec;9:1-32 [4620330.001]
  • [Cites] Lab Anim. 1977 Jan;11(1):1-28 [402499.001]
  • [Cites] J Nutr. 1977 Jul;107(7):1340-8 [874577.001]
  • [Cites] J Environ Pathol Toxicol. 1980 Nov;4(5-6):105-22 [7217840.001]
  • [Cites] Lab Anim Sci. 1980 Apr;30(2 Pt 2):352-65 [6892043.001]
  • [Cites] Fundam Appl Toxicol. 1984 Jun;4(3 Pt 2):S341-56 [6745553.001]
  • [Cites] Fundam Appl Toxicol. 1987 Aug;9(2):329-38 [3653575.001]
  • [Cites] J Nutr. 1993 Nov;123(11):1939-51 [8229312.001]
  • [Cites] Altern Med Rev. 1999 Jun;4(3):170-7 [10383481.001]
  • [Cites] NMR Biomed. 2005 May;18(3):143-62 [15627238.001]
  • [Cites] Lab Anim. 2005 Apr;39(2):230-5 [15901367.001]
  • [Cites] Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9960-5 [15987781.001]
  • [Cites] Lab Anim (NY). 2006 Jun;35(6):41-9 [16738591.001]
  • (PMID = 19930817.001).
  • [ISSN] 1559-6109
  • [Journal-full-title] Journal of the American Association for Laboratory Animal Science : JAALAS
  • [ISO-abbreviation] J. Am. Assoc. Lab. Anim. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2786923
  •  go-up   go-down


77. Onishi A, Yamamoto H, Akimoto T, Saito O, Inoue M, Ando Y, Muto S, Kusano E: Reversible acute renal failure associated with clomipramine-induced interstitial nephritis. Clin Exp Nephrol; 2007 Sep;11(3):241-3
Hazardous Substances Data Bank. Clomipramine .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a 41-year old man with obsessive-compulsive neurosis who developed acute renal failure (ARF) due to acute interstitial nephritis (AIN) during 6 weeks of treatment with clomipramine hydrochloride (CPH).
  • Renal biopsy revealed AIN with diffuse mononuclear cell infiltration.
  • To our knowledge, this is the first case report of AIN induced by clomipramine.
  • [MeSH-minor] Adult. Humans. Male. Obsessive-Compulsive Disorder / drug therapy

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17891354.001).
  • [ISSN] 1342-1751
  • [Journal-full-title] Clinical and experimental nephrology
  • [ISO-abbreviation] Clin. Exp. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Serotonin Uptake Inhibitors; NUV44L116D / Clomipramine
  •  go-up   go-down


78. Kirsch P, Assouar MB, Elmazria O, Hakiki ME, Mortet V, Alnot P: Combination of e-beam lithography and of high velocity AIN/diamond-layered structure for SAW filters in X band. IEEE Trans Ultrason Ferroelectr Freq Control; 2007 Jul;54(7):1486-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combination of e-beam lithography and of high velocity AIN/diamond-layered structure for SAW filters in X band.
  • In previous work, we have shown that high acoustic velocities (9 to 12 km/s) are obtained from the layered AIN/diamond structure.
  • The interdigital transducers (IDTs) made of aluminium with resolutions up to 250 nm were successfully patterned on AIN/diamond-layered structures with an adapted technological process.
  • The X-ray diffraction effectuated on the AIN/diamond-layered structure exhibits high intensity peaks related to the (002) AIN and (111) diamond orientations.
  • According to the calculated dispersion curves of velocity and the electromechanical coupling coefficient (K2), the AIN layer thickness was chosen in order to combine high velocity and high K2.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17718340.001).
  • [ISSN] 0885-3010
  • [Journal-full-title] IEEE transactions on ultrasonics, ferroelectrics, and frequency control
  • [ISO-abbreviation] IEEE Trans Ultrason Ferroelectr Freq Control
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
  •  go-up   go-down


79. Ogilvie JW Jr, Park IU, Downs LS, Anderson KE, Hansberger J, Madoff RD: Anal dysplasia in kidney transplant recipients. J Am Coll Surg; 2008 Dec;207(6):914-21
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal dysplasia in kidney transplant recipients.
  • BACKGROUND: Although the risk of anal cancer in immunosuppressed individuals is significantly higher than in the general population, methods for detecting precancerous anal dysplasia have not been well studied in solid-organ transplant recipients.
  • We sought to identify the incidence of anal dysplasia in kidney transplant recipients and associated factors that increase the likelihood of dysplasia.
  • We interviewed willing participants and performed anal cytology sampling and high-resolution anoscopy; if we found microscopic abnormalities, we performed biopsies.
  • We used univariate analysis to measure the association between variables and anal dysplasia.
  • Their median duration of immunosuppression was 5.6 years; 23 (59%) had fewer than 5 lifetime sexual partners, and 2 (5%) reported ever practicing anal intercourse.
  • Of all cytology specimens, 35 (88%) had sufficient cells for interpretation and 2 (6%) demonstrated dysplasia.
  • We performed biopsies in 11 patients; 6 had dysplasia (4 low-grade, 2 high-grade).
  • Of these patients, five had normal anal cytology.
  • The sensitivity of cytology to predict histologic evidence of dysplasia was 17%.
  • Overall, seven (18%) had dysplasia according to either cytology or histology specimens; two (5%) had high-grade dysplasia.
  • We found no significant associations between the tested variables and the presence of dysplasia.
  • CONCLUSIONS: A significant proportion of kidney transplant recipients harbor anal dysplasia.
  • One time anal cytology sampling was not predictive of histologic findings.
  • Although these findings confirm their high risk for dysplasia, a larger sample is required to more accurately quantify risk factors for dysplasia and progression to cancer.
  • [MeSH-major] Anus Neoplasms / immunology. Immunocompromised Host. Immunosuppressive Agents / adverse effects. Kidney Transplantation. Precancerous Conditions / immunology
  • [MeSH-minor] Anal Canal / pathology. Anus Diseases / immunology. Anus Diseases / pathology. Female. Humans. Male. Middle Aged. Prospective Studies

  • MedlinePlus Health Information. consumer health - Anal Cancer.
  • MedlinePlus Health Information. consumer health - Kidney Transplantation.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19183539.001).
  • [ISSN] 1879-1190
  • [Journal-full-title] Journal of the American College of Surgeons
  • [ISO-abbreviation] J. Am. Coll. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
  •  go-up   go-down


80. Kang MJ, Kim JH, Choi HN, Kim MJ, Han JH, Lee JH, Kim JI: Hypoglycemic effects of Welsh onion in an animal model of diabetes mellitus. Nutr Res Pract; 2010 Dec;4(6):486-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To study the hypoglycemic effects of chronic feeding of Welsh onion, five-week-old db/db mice were fed an AIN-93G diet or a diet containing either Welsh onion fibrous root extract at 0.5% or acarbose at 0.05% for 7 weeks after 1 week of adaptation.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Diabetes Care. 1999 Jun;22(6):960-4 [10372249.001]
  • [Cites] Diabetes Care. 2000 Aug;23(8):1162-7 [10937515.001]
  • [Cites] BMJ. 2000 Aug 12;321(7258):405-12 [10938048.001]
  • [Cites] Diabetes Obes Metab. 1999 Jul;1(4):215-20 [11228756.001]
  • [Cites] N Engl J Med. 2002 Feb 7;346(6):393-403 [11832527.001]
  • [Cites] Clin Chem. 2002 Mar;48(3):436-72 [11861436.001]
  • [Cites] Int J Biochem Cell Biol. 2005 Aug;37(8):1595-608 [15878838.001]
  • [Cites] Biosci Biotechnol Biochem. 2005 Jul;69(7):1311-7 [16041136.001]
  • [Cites] Clin Ther. 2005 Oct;27(10):1489-99 [16330287.001]
  • [Cites] Nutr Metab Cardiovasc Dis. 2006 Oct;16(7):453-6 [16934443.001]
  • [Cites] Yakugaku Zasshi. 2007 Mar;127(3):407-16 [17329926.001]
  • [Cites] Phytomedicine. 2009 Oct;16(10):935-41 [19380218.001]
  • [Cites] Biosci Biotechnol Biochem. 2010;74(2):402-4 [20139615.001]
  • [Cites] Nutr Res Pract. 2007 Fall;1(3):184-8 [20368936.001]
  • [Cites] Diabetes Care. 1998 Sep;21(9):1414-31 [9727886.001]
  • [Cites] Lancet. 1998 Sep 12;352(9131):837-53 [9742976.001]
  • [Cites] Expert Opin Pharmacother. 1999 Nov;1(1):149-56 [11249557.001]
  • [Cites] J Nutr. 2001 Apr;131(4):1211-3 [11285328.001]
  • [Cites] J Biochem Mol Toxicol. 2003;17(1):24-38 [12616644.001]
  • [Cites] J Ethnopharmacol. 2003 Apr;85(2-3):283-7 [12639753.001]
  • [Cites] Scand J Clin Lab Invest. 1960;12(4):402-7 [13738785.001]
  • [Cites] Arch Intern Med. 2004 Mar 8;164(5):486-91 [15006824.001]
  • [Cites] Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S149-55 [15563967.001]
  • [Cites] Clin Chem. 1980 Mar;26(3):466-72 [7363467.001]
  • [Cites] Drugs. 1993 Dec;46(6):1025-54 [7510610.001]
  • [Cites] Diabetes Care. 1995 Jun;18(6):817-24 [7555508.001]
  • [Cites] J Nutr. 1993 Nov;123(11):1939-51 [8229312.001]
  • [Cites] Diabetes Res Clin Pract. 1996 Jun;33(1):1-14 [8877270.001]
  • [Cites] Biosci Biotechnol Biochem. 1997 Jan;61(1):177-8 [9028049.001]
  • [Cites] J Diabetes Complications. 1998 Jul-Aug;12(4):228-37 [9647342.001]
  • [Cites] Diabetes Res Clin Pract. 1998 Jul;40 Suppl:S43-9 [9740502.001]
  • (PMID = 21286406.001).
  • [ISSN] 2005-6168
  • [Journal-full-title] Nutrition research and practice
  • [ISO-abbreviation] Nutr Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3029789
  • [Keywords] NOTNLM ; Welsh onion / diabetes / glucose / glycated hemoglobin / α-glucosidase inhibition
  •  go-up   go-down


81. Król E, Krejpcio Z: Chromium(III) propionate complex supplementation improves carbohydrate metabolism in insulin-resistance rat model. Food Chem Toxicol; 2010 Oct;48(10):2791-6
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Animals were fed at libitum: the control diet (AIN-93M), and high-fructose diets (HF) containing various levels of Cr(III) given as CrProp (1 mg Cr kg(-1) diet (HF) and supplemented with 10 mg Cr kg(-1) diet (HFCr10), or 50 mg Cr kg(-1) diet (HFCr50), equal to approx.

  • MedlinePlus Health Information. consumer health - Diabetes Medicines.
  • Hazardous Substances Data Bank. ZINC PROPIONATE .
  • Hazardous Substances Data Bank. PROPIONIC ACID .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20633590.001).
  • [ISSN] 1873-6351
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Hypoglycemic Agents; 0 / Insulin; 0 / Metals; 0 / Propionates; 30237-26-4 / Fructose; 79-09-4 / propionic acid
  •  go-up   go-down


82. Craciunescu CN, Johnson AR, Zeisel SH: Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain. J Nutr; 2010 Jun;140(6):1162-6
Hazardous Substances Data Bank. CHOLINE CHLORIDE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Timed-pregnant mice were fed control (CT), folate-deficient (FD), or folate-deficient, choline-supplemented (FDCS) AIN-76 diets from d 11 to 17 (E11-17) of pregnancy, and on E17, fetal brains were collected for analysis.

  • MedlinePlus Health Information. consumer health - Folic Acid.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Physiol Cell Physiol. 2000 Dec;279(6):C1889-95 [11078704.001]
  • [Cites] Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):9-16 [9263575.001]
  • [Cites] Nutr Rev. 2001 Jul;59(7):215-24 [11475447.001]
  • [Cites] FASEB J. 2001 Aug;15(10):1704-10 [11481217.001]
  • [Cites] FASEB J. 2001 Aug;15(10):1739-44 [11481221.001]
  • [Cites] Dev Neurosci. 2001;23(2):100-6 [11509832.001]
  • [Cites] J Biol Chem. 2001 Nov 2;276(44):41197-204 [11483591.001]
  • [Cites] Biomed Pharmacother. 2001 Oct;55(8):434-42 [11686576.001]
  • [Cites] J Histochem Cytochem. 2001 Dec;49(12):1565-72 [11724904.001]
  • [Cites] J Cell Physiol. 2002 May;191(2):173-82 [12064460.001]
  • [Cites] J Nutr. 2002 Jul;132(7):1840-7 [12097657.001]
  • [Cites] FASEB J. 2003 Mar;17(3):512-4 [12551843.001]
  • [Cites] Am J Epidemiol. 2003 Apr 1;157(7):583-91 [12672677.001]
  • [Cites] J Nutr. 2003 Nov;133(11):3614-8 [14608083.001]
  • [Cites] J Nutr. 2004 Jan;134(1):162-6 [14704311.001]
  • [Cites] Am J Epidemiol. 2004 Jul 15;160(2):102-9 [15234930.001]
  • [Cites] Anat Rec. 1970 Feb;166(2):257-61 [5414696.001]
  • [Cites] J Nutr. 1977 Jul;107(7):1340-8 [874577.001]
  • [Cites] Clin Chim Acta. 1985 Jun 30;149(1):1-12 [4028430.001]
  • [Cites] Jikken Dobutsu. 1989 Jul;38(3):245-52 [2792207.001]
  • [Cites] J Comp Neurol. 1990 Nov 15;301(3):325-42 [2262594.001]
  • [Cites] Cancer Res. 1991 Jan 1;51(1):16-21 [1988081.001]
  • [Cites] N Engl J Med. 1992 Dec 24;327(26):1832-5 [1307234.001]
  • [Cites] Endocr Rev. 1993 Apr;14(2):133-51 [8325248.001]
  • [Cites] Annu Rev Nutr. 1994;14:269-96 [7946521.001]
  • [Cites] J Nutr. 1994 Nov;124(11):2197-203 [7965204.001]
  • [Cites] FASEB J. 1999 Jan;13(1):135-42 [9872938.001]
  • [Cites] J Histochem Cytochem. 1999 Feb;47(2):229-36 [9889258.001]
  • [Cites] J Nutr. 1999 Jan;129(1):25-31 [9915871.001]
  • [Cites] Brain Res Dev Brain Res. 1999 Mar 12;113(1-2):13-20 [10064869.001]
  • [Cites] J Nutr. 1999 Apr;129(4):779-82 [10203550.001]
  • [Cites] Brain Res Dev Brain Res. 1999 Jun 2;115(2):123-9 [10407130.001]
  • [Cites] FASEB J. 2006 Jan;20(1):43-9 [16394266.001]
  • [Cites] Hum Mol Genet. 2006 Mar 1;15(5):705-16 [16421170.001]
  • [Cites] Epidemiology. 2006 May;17(3):285-91 [16570024.001]
  • [Cites] Genesis. 2006 Sep;44(9):401-6 [16868943.001]
  • [Cites] Birth Defects Res C Embryo Today. 2007 Sep;81(3):183-203 [17963270.001]
  • [Cites] Am J Clin Nutr. 2009 May;89(5):1488S-1493S [19261726.001]
  • [Cites] J Nutr. 2009 Dec;139(12):2402-5 [19812215.001]
  • [Cites] FASEB J. 2010 Jan;24(1):184-95 [19752176.001]
  • [Cites] Brain Res Mol Brain Res. 2005 Apr 4;134(2):309-22 [15836926.001]
  • [Cites] Adv Exp Med Biol. 1994;352:157-72 [7832045.001]
  • [Cites] Neurosci Lett. 1994 Nov 21;182(1):77-9 [7891894.001]
  • [Cites] JAMA. 1995 Dec 6;274(21):1698-702 [7474275.001]
  • [Cites] J Nutr. 1995 Dec;125(12):3049-54 [7500183.001]
  • [Cites] Prog Neurobiol. 1995 Oct;47(2):135-55 [8711131.001]
  • [Cites] J Neurobiol. 1996 Jul;30(3):315-28 [8807525.001]
  • [Cites] Neuron. 1996 Oct;17(4):579-85 [8893016.001]
  • [Cites] Brain Res. 1996 Sep 23;734(1-2):10-8 [8896803.001]
  • [Cites] Neuropathol Appl Neurobiol. 1996 Dec;22(6):489-94 [9004234.001]
  • [Cites] Carcinogenesis. 1997 Feb;18(2):287-93 [9054620.001]
  • [Cites] Development. 1997 Mar;124(6):1239-49 [9102310.001]
  • [Cites] Oncogene. 2001 May 28;20(24):3021-7 [11420717.001]
  • (PMID = 20392884.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P30 ES010126; United States / NIA NIH HHS / AG / AG09525; United States / NIDDK NIH HHS / DK / DK55865; United States / NIDDK NIH HHS / DK / DK56350
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] N91BDP6H0X / Choline
  • [Other-IDs] NLM/ PMC2869500
  •  go-up   go-down


83. Hwang JY, Lee SK, Jo JR, Kim ME, So HA, Cho CW, Seo YW, Kim JI: Hypolipidemic effect of Salicornia herbacea in animal model of type 2 diabetes mellitus. Nutr Res Pract; 2007;1(4):371-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Three week-old db/db mice (C57BL/KsJ, n=16) were fed AIN-93G semipurified diet or diet containing 1% desalted ethanol extract of S. herbacea for 6 weeks after 1 week of adaptation.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Diabetes Care. 1989 Sep;12(8):553-64 [2673695.001]
  • [Cites] Biosci Biotechnol Biochem. 1997 Jan;61(1):177-8 [9028049.001]
  • [Cites] BMJ. 1998 Sep 12;317(7160):703-13 [9732337.001]
  • [Cites] Diabetes Care. 1999 Jan;22(1):56-64 [10333904.001]
  • [Cites] Lipids. 1999 May;34(5):441-5 [10380115.001]
  • [Cites] Ann Nutr Metab. 2007;51(2):119-25 [17536188.001]
  • [Cites] Am J Cardiol. 2003 Apr 15;91(8):961-4 [12686336.001]
  • [Cites] Med J Aust. 2003 Nov 3;179(9):498-503 [14583083.001]
  • [Cites] Int J Biochem Cell Biol. 2005 Aug;37(8):1595-608 [15878838.001]
  • [Cites] Arch Pharm Res. 2006 Mar;29(3):256-64 [16597000.001]
  • [Cites] Eur J Pharmacol. 2002 Apr 12;440(2-3):109-17 [12007529.001]
  • (PMID = 20368964.001).
  • [ISSN] 2005-6168
  • [Journal-full-title] Nutrition research and practice
  • [ISO-abbreviation] Nutr Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2849048
  • [Keywords] NOTNLM ; Diabetes mellitus / Salicornia herbacea / cholesterol / db/db mouse / triglyceride
  •  go-up   go-down


84. Mejia LA, Korgaonkar CK, Schweizer M, Chengelis C, Novilla M, Ziemer E, Williamson-Hughes PS, Grabiel R, Empie M: A 13-week dietary toxicity study in rats of a Napin-Rich Canola Protein Isolate. Regul Toxicol Pharmacol; 2009 Dec;55(3):394-402
MedlinePlus Health Information. consumer health - Body Weight.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • They were fed ad libitum with an AIN-93G based protein-free diet containing, respectively, 5%, 10% and 20% (w/w) NRCPI (test article) or 20% (w/w) vitamin-free casein (control article).

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19766157.001).
  • [ISSN] 1096-0295
  • [Journal-full-title] Regulatory toxicology and pharmacology : RTP
  • [ISO-abbreviation] Regul. Toxicol. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 2S Albumins, Plant; 89147-51-3 / napin protein, Brassica napus
  •  go-up   go-down


85. Du YP, Peng JS, Sun A, Tang ZH, Ling WH, Zhu HL: Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model. BMC Cancer; 2009;9:261
Hazardous Substances Data Bank. N-NITROSODIETHYLAMINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Four groups of rats were given diethylinitrosamine (DEN) and fed with AIN-93G diets supplemented with 0, 10, 20 or 40 g betaine/kg (model, 1%, 2%, and 4% betaine, respectively), while the control group, received no DEN, fed with AIN-93G diet.

  • Genetic Alliance. consumer health - Liver cancer.
  • MedlinePlus Health Information. consumer health - Liver Cancer.
  • Hazardous Substances Data Bank. BETAINE .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Jpn J Cancer Res. 1999 Sep;90(9):909-13 [10551317.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2260-7 [18723830.001]
  • [Cites] Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8 [11559025.001]
  • [Cites] Chem Res Toxicol. 2002 Mar;15(3):438-44 [11896693.001]
  • [Cites] Mutat Res. 2003 Feb 5;535(1):73-8 [12547284.001]
  • [Cites] J Environ Pathol Toxicol Oncol. 2003;22(3):179-99 [14529093.001]
  • [Cites] Food Chem Toxicol. 2003 Dec;41(12):1685-700 [14563394.001]
  • [Cites] J Korean Med Sci. 2004 Feb;19(1):83-6 [14966347.001]
  • [Cites] World J Gastroenterol. 2004 May 1;10(9):1276-80 [15112341.001]
  • [Cites] Am J Clin Nutr. 2004 Sep;80(3):539-49 [15321791.001]
  • [Cites] Amino Acids. 2004 Oct;27(2):199-205 [15338317.001]
  • [Cites] J Nutr. 1993 Nov;123(11):1939-51 [8229312.001]
  • [Cites] Cancer Res. 1999 Jan 1;59(1):71-3 [9892188.001]
  • [Cites] J Nutr Biochem. 2004 Nov;15(11):666-71 [15590270.001]
  • [Cites] Carcinogenesis. 2005 Jan;26(1):125-31 [15459019.001]
  • [Cites] J Nutr. 2005 Mar;135(3):519-24 [15735087.001]
  • [Cites] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078.001]
  • [Cites] Cell Res. 2005 Apr;15(4):272-80 [15857582.001]
  • [Cites] J Hepatol. 2005 Jun;42(6):842-9 [15885355.001]
  • [Cites] Am J Clin Nutr. 2005 Jun;81(6):1378-82 [15941890.001]
  • [Cites] Mol Cancer Res. 2005 Jul;3(7):403-12 [16046551.001]
  • [Cites] BMC Cancer. 2005;5:95 [16080796.001]
  • [Cites] Fitoterapia. 2005 Sep;76(6):549-55 [16009505.001]
  • [Cites] Biochem Pharmacol. 2005 Dec 5;70(12):1883-90 [16253211.001]
  • [Cites] Mutat Res. 2006 Jan 29;593(1-2):80-7 [16144704.001]
  • [Cites] J Biol Chem. 2006 Feb 10;281(6):3283-9 [16352593.001]
  • [Cites] Carcinogenesis. 2006 Apr;27(4):748-57 [16339184.001]
  • [Cites] Hepatology. 2006 Apr;43(4):796-806 [16557551.001]
  • [Cites] World J Gastroenterol. 2006 Mar 21;12(11):1718-22 [16586540.001]
  • [Cites] Cancer Causes Control. 2006 May;17(4):509-14 [16596304.001]
  • [Cites] Cell. 2006 Oct 20;127(2):265-75 [17055429.001]
  • [Cites] J Nutr. 2007 Jan;137(1 Suppl):223S-228S [17182830.001]
  • [Cites] Chem Biol Interact. 2007 Apr 5;167(1):12-8 [17289008.001]
  • [Cites] Nat Clin Pract Oncol. 2007 May;4(5):305-15 [17464338.001]
  • [Cites] Am J Clin Nutr. 2007 Jul;86(1):14-24 [17616758.001]
  • [Cites] Int J Biochem Cell Biol. 2007;39(12):2215-25 [17683969.001]
  • [Cites] Carcinogenesis. 2008 Mar;29(3):638-46 [18204080.001]
  • [Cites] Mol Cell Biochem. 2008 May;312(1-2):1-9 [18273562.001]
  • [Cites] Eur J Surg Oncol. 2008 May;34(5):541-6 [17764885.001]
  • [Cites] Cancer Res. 2008 Jun 1;68(11):4133-41 [18519672.001]
  • [Cites] PLoS One. 2008;3(6):e2493 [18560566.001]
  • [Cites] J Nutr. 2008 Sep;138(9):1641-6 [18716163.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1162-8 [11093938.001]
  • (PMID = 19642983.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Proto-Oncogene Proteins c-myc; 3IQ78TTX1A / Diethylnitrosamine; 3SCV180C9W / Betaine
  • [Other-IDs] NLM/ PMC2733901
  •  go-up   go-down


86. Abd-El-Maeboud KH, Ibrahim MI, Shalaby DA, Fikry MF: Gum chewing stimulates early return of bowel motility after caesarean section. BJOG; 2009 Sep;116(10):1334-9
MedlinePlus Health Information. consumer health - Cesarean Section.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • SETTING: Faculty of Medicine, Ain Shams University, Egypt.

  • MedlinePlus Health Information. consumer health - After Surgery.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] BJOG. 2010 Jan;117(1):117; author reply 117-8 [20002378.001]
  • (PMID = 19523094.001).
  • [ISSN] 1471-0528
  • [Journal-full-title] BJOG : an international journal of obstetrics and gynaecology
  • [ISO-abbreviation] BJOG
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chewing Gum; 0 / Gases
  •  go-up   go-down


87. Ronis MJ, Chen Y, Badeaux J, Badger TM: Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling. J Nutr; 2009 Aug;139(8):1431-8
Hazardous Substances Data Bank. CHOLESTEROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To determine the effects of feeding soy or isoflavones on lipid homeostasis in early development, weanling rats were fed AIN-93G diets made with casein, soy protein isolate (SPI+), isoflavone-reduced SPI+ (SPI-), or casein supplemented with genistein or daidzein for 14 d.

  • MedlinePlus Health Information. consumer health - Metabolic Syndrome.
  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. GENISTEIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19515742.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticholesteremic Agents; 0 / Caseins; 0 / DNA-Binding Proteins; 0 / Dietary Fats; 0 / Isoflavones; 0 / Orphan Nuclear Receptors; 0 / PPAR alpha; 0 / PPAR gamma; 0 / RNA, Messenger; 0 / Receptors, Cytoplasmic and Nuclear; 0 / Soybean Proteins; 0 / Sterol Regulatory Element Binding Protein 1; 0 / liver X receptor; 6287WC5J2L / daidzein; 97C5T2UQ7J / Cholesterol; DH2M523P0H / Genistein
  •  go-up   go-down


88. El-Saify MY, Shaheen MA, Sabbour SM, Basal AA: Nocturnal attacks, emergency room visits and ICU admission of pediatric asthma: frequency and associated factors. J Egypt Public Health Assoc; 2008;83(5-6):353-67
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Records of asthmatic children in the pediatric chest clinic, Ain Shams University during 1995-2004 were reviewed.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19493506.001).
  • [ISSN] 0013-2446
  • [Journal-full-title] The Journal of the Egyptian Public Health Association
  • [ISO-abbreviation] J Egypt Public Health Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  •  go-up   go-down


89. Blais A, Malet A, Mikogami T, Martin-Rouas C, Tomé D: Oral bovine lactoferrin improves bone status of ovariectomized mice. Am J Physiol Endocrinol Metab; 2009 Jun;296(6):E1281-8
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Twelve-week-old female C3H mice either ovariectomized or sham operated were fed for 27 wk with the control diet (AIN-93M with 140 g of total milk protein as a protein source per kg of diet).

  • MedlinePlus Health Information. consumer health - Bone Density.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19336659.001).
  • [ISSN] 0193-1849
  • [Journal-full-title] American journal of physiology. Endocrinology and metabolism
  • [ISO-abbreviation] Am. J. Physiol. Endocrinol. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.- / Lactoferrin
  •  go-up   go-down


90. Suh M, Sauvé Y, Merrells KJ, Kang JX, Ma DW: Supranormal electroretinogram in fat-1 mice with retinas enriched in docosahexaenoic acid and n-3 very long chain fatty acids (C24-C36). Invest Ophthalmol Vis Sci; 2009 Sep;50(9):4394-401
Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Supranormal electroretinogram in fat-1 mice with retinas enriched in docosahexaenoic acid and n-3 very long chain fatty acids (C24-C36).
  • PURPOSE: Fat-1 mice can convert n-6 to n-3 fatty acids endogenously, resulting in the accumulation of n-3 fatty acids in major tissues.
  • METHODS: Both wild-type (WT) and fat-1 mice were fed a modified AIN-93G diet containing 10% safflower oil, high in 18:2n-6.
  • CONCLUSIONS: Highly enriched DHA and n-3 VLCFA in the retina lead to supernormal scotopic and photopic ERGs and increases in Müller cell reactivity and oxidative stress in photoreceptors.
  • The regulation of n-3 fatty acids levels and of the n-6/n-3 fatty acid ratio are essential in preserving retinal integrity.

  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. SAFFLOWER OIL .
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19264893.001).
  • [ISSN] 1552-5783
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / Fatty Acids; 0 / Fatty Acids, Omega-3; 0 / Fatty Acids, Omega-6; 0 / Glial Fibrillary Acidic Protein; 0 / Phospholipids; 0 / fat-1 protein, C elegans; 25167-62-8 / Docosahexaenoic Acids; 8001-23-8 / Safflower Oil; EC 1.14.19.- / Fatty Acid Desaturases
  •  go-up   go-down


91. Bommareddy A, Zhang X, Schrader D, Kaushik RS, Zeman D, Matthees DP, Dwivedi C: Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. Nutr Cancer; 2009;61(2):276-83
Hazardous Substances Data Bank. Corn oil .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Apc(Min) mice were divided into five different groups, fed with control (AIN-93M meal), corn meal, flaxseed meal, corn oil, and flaxseed oil supplemented diets.

  • COS Scholar Universe. author profiles.
  • Hazardous Substances Data Bank. LINSEED OIL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19235044.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Fatty Acids; 0 / Fatty Acids, Omega-3; 0 / Lignans; 0RBV727H71 / alpha-Linolenic Acid; 8001-26-1 / Linseed Oil; 8001-30-7 / Corn Oil; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; MO0N1J0SEN / Azoxymethane
  •  go-up   go-down


92. Joo YE, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C: Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. PLoS One; 2009;4(2):e4562
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODOLOGY/PRINCIPAL FINDINGS: Mice were fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76).
  • Murine splenocytes and intestinal epithelial cells were used to determine the in vitro impact of TLE on LPS-induced NF-kappaB signaling.
  • CONCLUSIONS/ SIGNIFICANCE: These results indicate that TLE prevents LPS-induced proinflammatory gene expression by blocking of NF-kappaB signaling, but aggravates DSS-induced colitis by enhancing epithelial cell apoptosis.

  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Exp Biol Med (Maywood). 2002 Nov;227(10):852-9 [12424325.001]
  • [Cites] J Biol Chem. 2002 Oct 11;277(41):38168-78 [12140289.001]
  • [Cites] Gastroenterology. 2002 Dec;123(6):1912-22 [12454848.001]
  • [Cites] J Gastroenterol. 2004 Jun;39(6):514-9 [15235867.001]
  • [Cites] Genes Dev. 2004 Sep 15;18(18):2195-224 [15371334.001]
  • [Cites] Immunology. 2004 Oct;113(2):203-11 [15379981.001]
  • [Cites] Arch Biochem Biophys. 1989 Nov 1;274(2):532-8 [2802626.001]
  • [Cites] J Biol Chem. 1992 Mar 5;267(7):4658-63 [1537849.001]
  • [Cites] J Immunol. 1997 Jan 1;158(1):226-34 [8977194.001]
  • [Cites] FEBS Lett. 1998 May 8;427(2):305-8 [9607334.001]
  • [Cites] Gastroenterology. 1998 Jul;115(1):182-205 [9649475.001]
  • [Cites] Nutr Cancer. 1998;31(3):199-203 [9795972.001]
  • [Cites] Lipids. 1998 Oct;33(10):981-4 [9832077.001]
  • [Cites] J Immunol. 1999 Sep 15;163(6):3474-83 [10477620.001]
  • [Cites] Nature. 2005 Apr 28;434(7037):1138-43 [15858576.001]
  • [Cites] Clin Exp Immunol. 2005 Jun;140(3):547-55 [15932518.001]
  • [Cites] Immunology. 2005 Jul;115(3):375-87 [15946255.001]
  • [Cites] Mol Aspects Med. 2005 Dec;26(6):459-516 [16309738.001]
  • [Cites] Cell Death Differ. 2006 May;13(5):759-72 [16410803.001]
  • [Cites] J Clin Invest. 2007 Mar;117(3):514-21 [17332878.001]
  • [Cites] J Immunol. 2007 May 15;178(10):6522-32 [17475882.001]
  • [Cites] PLoS One. 2007;2(7):e596 [17611628.001]
  • [Cites] Nature. 2007 Jul 26;448(7152):427-34 [17653185.001]
  • [Cites] J Immunol. 2007 Dec 1;179(11):7852-9 [18025231.001]
  • [Cites] Inflamm Bowel Dis. 2008 Jan;14(1):114-24 [17763472.001]
  • [Cites] Gastroenterology. 2008 Feb;134(2):577-94 [18242222.001]
  • [Cites] Am J Clin Nutr. 2000 Jun;71(6 Suppl):1691S-5S; discussion 1696S-7S [10837319.001]
  • [Cites] J Am Coll Nutr. 2000 Oct;19(5):563-9 [11022869.001]
  • [Cites] Drug Metabol Drug Interact. 2000;17(1-4):189-210 [11201295.001]
  • [Cites] J Nutr. 2002 Aug;132(8):2288-97 [12163677.001]
  • [Cites] N Engl J Med. 2002 Aug 8;347(6):417-29 [12167685.001]
  • [Cites] Exp Biol Med (Maywood). 2002 Nov;227(10):920-3 [12424335.001]
  • (PMID = 19234608.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / P30 DK034987; United States / NIDDK NIH HHS / DK / R01 DK047700; United States / NIDDK NIH HHS / DK / R56 DK047700; United States / NIDDK NIH HHS / DK / R0I DK 47700
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopolysaccharides; 0 / NF-kappa B; 0 / Plant Extracts; 0 / enhanced green fluorescent protein; 147336-22-9 / Green Fluorescent Proteins; 36-88-4 / Carotenoids; 9042-14-2 / Dextran Sulfate; SB0N2N0WV6 / lycopene
  • [Other-IDs] NLM/ PMC2642995
  •  go-up   go-down


93. Yokoi K, Konomi A, Otagi M: Iron bioavailability of cocoa powder as determined by the Hb regeneration efficiency method. Br J Nutr; 2009 Jul;102(2):215-20
Hazardous Substances Data Bank. FERROUS SULFATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Then, four groups of seven animals each were repleted for 20 d using a modified AIN-93G diet fortified with ferrous sulphate, ferric citrate or two brands of cocoa powder to provide a total dietary Fe concentration of 20 mg/kg.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19102811.001).
  • [ISSN] 1475-2662
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ferric Compounds; 0 / Ferrous Compounds; 0 / Hematinics; 0 / Hemoglobins; 0 / Iron, Dietary; 39R4TAN1VT / ferrous sulfate; 63G354M39Z / ferric citrate
  •  go-up   go-down


94. Bebe FN, Panemangalore M: Biosafety of flavonoids in rats: effects on copper and zinc homeostasis and interaction with low-level pesticide exposure. Biol Trace Elem Res; 2009;129(1-3):200-12
Hazardous Substances Data Bank. ZINC, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In experiment 1, PM = chlorpyrifos, endosulfan, and thiram at 25% LD(50) was dissolved in soybean (SB) oil and gavage-fed 0.1 mL 5 days/week; FM in SB oil was mixed in AIN-93M diet at 1.0 and 5.0 mM/kg diet and fed ad libitum.

  • MedlinePlus Health Information. consumer health - Pesticides.
  • Hazardous Substances Data Bank. COPPER, ELEMENTAL .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19099207.001).
  • [ISSN] 1559-0720
  • [Journal-full-title] Biological trace element research
  • [ISO-abbreviation] Biol Trace Elem Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Flavonoids; 0 / Pesticides; 789U1901C5 / Copper; J41CSQ7QDS / Zinc
  •  go-up   go-down


95. Bang HJ, Arakawa C, Takada M, Sato M, Imaizumi K: A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels. Biosci Biotechnol Biochem; 2008 Dec;72(12):3128-33
Hazardous Substances Data Bank. CHOLESTEROL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • C57BL/6J mice were fed an AIN-93G-based diet containing 0.2 g/kg of oxycholesterol or oxyphytosterol for 4 weeks.

  • MedlinePlus Health Information. consumer health - Cholesterol.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19060413.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cholesterol, Dietary; 0 / Hydroxycholesterols; 0 / Phytosterols; 0 / Triglycerides; 47IMW63S3F / 24-hydroxycholesterol; 97C5T2UQ7J / Cholesterol
  •  go-up   go-down


96. Kim HA, Jeong KS, Kim YK: Soy extract is more potent than genistein on tumor growth inhibition. Anticancer Res; 2008 Sep-Oct;28(5A):2837-41
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Four-week-old female athymic nude mice (Balb/c) were acclimatized to an AIN-93G control diet for one week prior to initiating the experimental diets.
  • The animals were placed into three treatment groups, each of which was provided with containing DMSO, genistein (750 microg/g AIN-93G diet) or 0.6% soy extract (containing genistein at 750 microg/g AIN-93G diet) for three weeks from one week prior to the injection of MDA-MB-231 cells (1 x 10(6)/site) and subsequently fed on the AIN-93G control diet until sacrifice.

  • MedlinePlus Health Information. consumer health - Breast Cancer.
  • Hazardous Substances Data Bank. GENISTEIN .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19035319.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Plant Extracts; DH2M523P0H / Genistein
  •  go-up   go-down


97. Nones K, Dommels YE, Martell S, Butts C, McNabb WC, Park ZA, Zhu S, Hedderley D, Barnett MP, Roy NC: The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases. Br J Nutr; 2009 Jan;101(2):169-81
Hazardous Substances Data Bank. CURCUMIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Damage of the intestinal epithelial barrier by xenobiotics or reactive oxygen species and a dysregulated immune response are both factors involved in the pathogenesis of inflammatory bowel diseases (IBD).
  • Twelve mice were randomly assigned to each of three diets (control (AIN-76A), control +0.2% curcumin or control +0.1% rutin) and monitored from the age of 7 to 24 weeks.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18761777.001).
  • [ISSN] 1475-2662
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / P-Glycoproteins; 0 / multidrug resistance protein 3; 5G06TVY3R7 / Rutin; IT942ZTH98 / Curcumin
  •  go-up   go-down


98. Nakashima Y, Tsukita Y, Yokoyama M: Preferential fat intake of pups nursed by dams fed low fat diet during pregnancy and lactation is higher than that of pups nursed by dams fed control diet and high fat diet. J Nutr Sci Vitaminol (Tokyo); 2008 Jun;54(3):215-22
MedlinePlus Health Information. consumer health - Dietary Fats.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It was considered that pups nursed by dams fed CTD and HFD self-selected FPD and CPD in an adequate fat energy ratio (F ratio) compared to that of AIN-93G and AIN-93M.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18635908.001).
  • [ISSN] 0301-4800
  • [Journal-full-title] Journal of nutritional science and vitaminology
  • [ISO-abbreviation] J. Nutr. Sci. Vitaminol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Dietary Carbohydrates; 0 / Dietary Fats; 0 / Dietary Proteins; 0 / Lipids
  •  go-up   go-down


99. El Guindy AA, Nabhan AF: A randomized trial of tight vs. less tight control of mild essential and gestational hypertension in pregnancy. J Perinat Med; 2008;36(5):413-8
Hazardous Substances Data Bank. METHYLDOPA .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: A randomized trial was conducted in 2006-2007 in the University of Ain Shams, Egypt.


100. Hooshmand S, Balakrishnan A, Clark RM, Owen KQ, Koo SI, Arjmandi BH: Dietary l-carnitine supplementation improves bone mineral density by suppressing bone turnover in aged ovariectomized rats. Phytomedicine; 2008 Aug;15(8):595-601
Hazardous Substances Data Bank. L-CARNITINE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • (1) a control group in which rats were fed ad libitum a carnitine-free (-CN) diet (AIN-93M) and (2) another fed the same diet but supplemented with l-carnitine (+CN).

  • MedlinePlus Health Information. consumer health - Bone Density.
  • MedlinePlus Health Information. consumer health - Dietary Supplements.
  • MedlinePlus Health Information. consumer health - Seniors' Health.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18539446.001).
  • [ISSN] 1618-095X
  • [Journal-full-title] Phytomedicine : international journal of phytotherapy and phytopharmacology
  • [ISO-abbreviation] Phytomedicine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Isoenzymes; 0 / RNA, Messenger; 12001-76-2 / Vitamin B Complex; EC 3.1.3.- / tartrate-resistant acid phosphatase; EC 3.1.3.1 / Alkaline Phosphatase; EC 3.1.3.2 / Acid Phosphatase; S7UI8SM58A / Carnitine
  •  go-up   go-down






Advertisement