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1. Haddada FM, Manaï H, Oueslati I, Daoud D, Sánchez J, Osorio E, Zarrouk M: Fatty acid, triacylglycerol, and phytosterol composition in six Tunisian olive varieties. J Agric Food Chem; 2007 Dec 26;55(26):10941-6
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  • Oleic and linoleic acids were the most useful fatty acids to discriminate three cultivars, Neb Jmel, Chétoui, and Ain Jarboua, from the others.

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  • (PMID = 18044828.001).
  • [ISSN] 0021-8561
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids; 0 / Phytosterols; 0 / Triglycerides
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2. Fung YL, Pitcher LA, Taylor K, Minchinton RM: Managing passively acquired autoimmune neonatal neutropenia: a case study. Transfus Med; 2005 Apr;15(2):151-5
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  • Pregnant women with autoimmune neutropenia (AIN) and circulating neutrophil-specific autoantibodies can deliver neutropenic neonates at risk of sepsis.

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  • (PMID = 15859983.001).
  • [ISSN] 0958-7578
  • [Journal-full-title] Transfusion medicine (Oxford, England)
  • [ISO-abbreviation] Transfus Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Recombinant Proteins; 143011-72-7 / Granulocyte Colony-Stimulating Factor
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3. Shalaby SA, Elmasry MK, Abd-Elrahman AE, Abd-Elkarim MA, Abd-Elhaleem ZA: Clinical profile of acute paraphenylenediamine intoxication in Egypt. Toxicol Ind Health; 2010 Mar;26(2):81-7
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  • It was conducted over 7 years (2001-2008) on 25 cases with acute PPD intoxication admitted to the Poison Control Center Ain Shams University Hospitals, Cairo, Egypt.

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  • (PMID = 20103579.001).
  • [ISSN] 1477-0393
  • [Journal-full-title] Toxicology and industrial health
  • [ISO-abbreviation] Toxicol Ind Health
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Phenylenediamines; EC 2.7.3.2 / Creatine Kinase; U770QIT64J / 4-phenylenediamine
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4. Pini R, Lucchina S, Garavaglia G, Fusetti C: False aneurysm of the interosseous artery and anterior interosseous syndrome--an unusual complication of penetrating injury of the forearm: a case report. J Orthop Surg Res; 2009;4:44
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  • BACKGROUND: Palsies involving the anterior interosseous nerve (AIN) comprise less than 1% of all upper extremity nerve palsies.

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  • (PMID = 20034382.001).
  • [ISSN] 1749-799X
  • [Journal-full-title] Journal of orthopaedic surgery and research
  • [ISO-abbreviation] J Orthop Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2804681
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5. Sato M, Yamada Y, Matsuoka H, Nakashima S, Kamiya T, Ikeguchi M, Imaizumi K: Dietary pine bark extract reduces atherosclerotic lesion development in male ApoE-deficient mice by lowering the serum cholesterol level. Biosci Biotechnol Biochem; 2009 Jun;73(6):1314-7
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  • Male and female mice were fed a diet based on an AIN-76 formula (control diet), and that diet supplemented with 2% PBE (the PBF diet).

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  • (PMID = 19502728.001).
  • [ISSN] 1347-6947
  • [Journal-full-title] Bioscience, biotechnology, and biochemistry
  • [ISO-abbreviation] Biosci. Biotechnol. Biochem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Plant Extracts; 97C5T2UQ7J / Cholesterol
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6. Abdel-Hameed DM, Hassanein OM: Genotyping of Toxoplasma gondii strains from female patients with toxoplasmosis. J Egypt Soc Parasitol; 2008 Aug;38(2):511-20
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  • Thirty-eight female patients with abortion and intrauterine fetal death were selected from the Obstetric and Gynecology Emergency, Ain Shams University Hospitals, with positive PCR results for toxoplasmosis in previous study.

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  • (PMID = 18853624.001).
  • [ISSN] 1110-0583
  • [Journal-full-title] Journal of the Egyptian Society of Parasitology
  • [ISO-abbreviation] J Egypt Soc Parasitol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Antigens, Protozoan; 0 / DNA, Protozoan; 0 / Protozoan Proteins; 133134-61-9 / surface antigen P22, Toxoplasma
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7. Ramana BV, Raju TN, Kumar VV, Reddy PU: Defensive role of quercetin against imbalances of calcium, sodium, and potassium in galactosemic cataract. Biol Trace Elem Res; 2007 Oct;119(1):35-41
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  • Different groups received normal stock AIN 93 diet (group A, n = 8), AIN 93 diet with 30% galactose (group B, n = 8), and AIN 93 diet with 30% galactose + quercetin at 400 mg/100 g diet (group C, n = 8).

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  • (PMID = 17914217.001).
  • [ISSN] 0163-4984
  • [Journal-full-title] Biological trace element research
  • [ISO-abbreviation] Biol Trace Elem Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9IKM0I5T1E / Quercetin; 9NEZ333N27 / Sodium; EC 1.1.1.21 / Aldehyde Reductase; RWP5GA015D / Potassium; SY7Q814VUP / Calcium
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8. Hefny AF, Eid HO, Al-Hussona M, Idris KM, Abu-Zidan FM: Necrotizing fasciitis: a challenging diagnosis. Eur J Emerg Med; 2007 Feb;14(1):50-2
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  • [Title] Necrotizing fasciitis: a challenging diagnosis.
  • The objective of the study was to evaluate our recent experience in diagnosis and management of necrotizing fasciitis.
  • Records of patients who were diagnosed as having necrotizing fasciitis at Al-Ain Hospital in the period between March 2003 and August 2005 were studied retrospectively with regard to clinical features, risk factors, diagnosis, causative organisms, treatment, and outcome.
  • The provisional clinical diagnosis was incorrect in seven patients (64%).
  • High clinical suspicion is essential for the diagnosis of necrotizing fasciitis.
  • Accurate early diagnosis, aggressive resuscitation, using proper antibiotics, and extensive surgical debridement are essential for a favorable outcome.
  • [MeSH-major] Fasciitis, Necrotizing / diagnosis. Streptococcal Infections / complications
  • [MeSH-minor] Adolescent. Adult. Aged. Anti-Bacterial Agents / therapeutic use. Child. Debridement. Diabetes Complications / diagnosis. Diabetes Complications / therapy. Diagnostic Errors. Female. Humans. Length of Stay. Male. Middle Aged. Retrospective Studies. Risk Factors. Social Class. Streptococcus / isolation & purification

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  • (PMID = 17198329.001).
  • [ISSN] 0969-9546
  • [Journal-full-title] European journal of emergency medicine : official journal of the European Society for Emergency Medicine
  • [ISO-abbreviation] Eur J Emerg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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9. Almansori M, Kovithavongs T, Qarni MU: Cyclooxygenase-2 inhibitor-associated minimal-change disease. Clin Nephrol; 2005 May;63(5):381-4
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  • Although the recent data suggests that COX-2 inhibitors may have the same adverse renal effect as NSAIDs, there is only one case report describing minimal change disease and acute interstitial nephritis (AIN) associated with a COX-2 inhibitor, celecoxib.

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  • (PMID = 15909598.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Cyclooxygenase Inhibitors
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10. Mostafa E, Nasar MN, Rabie NA, Ibrahim SA, Barakat HM, Rabie AN: Induction chemotherapy with paclitaxel and cisplatin, followed by concomitant cisplatin and radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma. J Egypt Natl Canc Inst; 2006 Dec;18(4):348-56
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  • PURPOSE: To evaluate the efficacy and outcome of neoadjuvant paclitaxel and cisplatin chemotherapy followed by concurrent cisplatin and irradiation in patients with locally advanced nasopharyngeal (NP) squamous cell carcinoma.
  • PATIENTS AND METHODS: The trial included 36 patients with locally advanced nasopharyngeal squamous carcinoma presented to Radiation Oncology and Otolaryngology departments-Ain Shams university hospitals, and Sohag Cancer Center between November 2002 and March 2006.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Cisplatin / administration & dosage. Nasopharyngeal Neoplasms / drug therapy. Nasopharyngeal Neoplasms / radiotherapy. Paclitaxel / administration & dosage. Radiotherapy. Radiotherapy, Adjuvant

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  • (PMID = 18301458.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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11. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H, Hou M, Ma J, Tang Z, Ling W: Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr; 2008 Feb;138(2):311-5
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  • These included an AIN-93G control diet (C), this C diet supplemented with methionine (M), the M diet deficient in folates, vitamin B-6, and vitamin B-12 (M-V), this M diet supplemented with these B vitamins (M+V), and a C diet deficient in B vitamins (C-V).

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  • [CommentIn] J Nutr. 2008 May;138(5):980; author reply 981 [18424611.001]
  • (PMID = 18203897.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apolipoproteins E; 0 / Biomarkers; 0LVT1QZ0BA / Homocysteine; 8059-24-3 / Vitamin B 6; 935E97BOY8 / Folic Acid; 979-92-0 / S-Adenosylhomocysteine; AE28F7PNPL / Methionine; P6YC3EG204 / Vitamin B 12
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12. Tharappel JC, Lehmler HJ, Srinivasan C, Robertson LW, Spear BT, Glauert HP: Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem Toxicol; 2008 Nov;46(11):3467-74
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  • Female Sprague Dawley rats were first injected with diethylnitrosamine (DEN, 150 mg/kg) and one week later the rats were fed an AIN-93 based purified diet or the same diet containing ellagic acid (0.4%), beta-carotene (0.5%), curcumin (0.5%), N-acetyl cysteine (NAC, 1.0%), coenzyme CoQ10 (CoQ10, 0.4%), resveratrol (0.005%), lycopene (10% as Lycovit, which contains 10% lycopene), or a tea extract (1%, containing 16.5% epigallocatechin-3-gallate [EGCG] and 33.4% total catechins).

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  • (PMID = 18796325.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / P42 ES013661-02; United States / NIEHS NIH HHS / ES / ES013661-02S2; United States / NIEHS NIH HHS / ES / P42 ES007380-050003; United States / NIEHS NIH HHS / ES / P42 ES007380-040003; United States / NIEHS NIH HHS / ES / ES013661; United States / NIEHS NIH HHS / ES / P42 ES013661-020001; United States / NIEHS NIH HHS / ES / P42 ES013661-030001; United States / NIEHS NIH HHS / ES / ES013661-02S1; United States / NIEHS NIH HHS / ES / ES007380-060003; United States / NIEHS NIH HHS / ES / ES007380-050003; United States / NIEHS NIH HHS / ES / P42 ES007380; United States / NIEHS NIH HHS / ES / K25 ES012475-01A1; United States / NIEHS NIH HHS / ES / ES013661-020001; United States / NIEHS NIH HHS / ES / P42 ES013661-01A10001; United States / NIEHS NIH HHS / ES / P42 ES013661-01A1; United States / NIEHS NIH HHS / ES / ES07380; United States / NIEHS NIH HHS / ES / K25 ES012475; United States / NIEHS NIH HHS / ES / ES013661-01A10001; United States / NIEHS NIH HHS / ES / ES013661-03S1; United States / NIEHS NIH HHS / ES / P42 ES013661-03S1; United States / NIEHS NIH HHS / ES / ES007380-080003; United States / NIEHS NIH HHS / ES / P42 ES013661-02S2; United States / NIEHS NIH HHS / ES / ES013661-030001; United States / NIEHS NIH HHS / ES / P42 ES013661; United States / NIEHS NIH HHS / ES / P42 ES013661-03; United States / NIEHS NIH HHS / ES / P42 ES007380-070003; United States / NIEHS NIH HHS / ES / P42 ES007380-080003; United States / NIEHS NIH HHS / ES / P42 ES007380-060003; United States / NIEHS NIH HHS / ES / ES007380-070003; United States / NIEHS NIH HHS / ES / ES012475; United States / NIEHS NIH HHS / ES / ES007380-040003; United States / NIEHS NIH HHS / ES / ES012475-01A1; United States / NIEHS NIH HHS / ES / P42 ES013661-02S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Carcinogens, Environmental; 1339-63-5 / Ubiquinone; 19YRN3ZS9P / Ellagic Acid; 32598-13-3 / 3,4,3',4'-tetrachlorobiphenyl; 36-88-4 / Carotenoids; DFC2HB4I0K / Polychlorinated Biphenyls; EC 2.5.1.18 / Glutathione Transferase; EJ27X76M46 / coenzyme Q10; IT942ZTH98 / Curcumin; SB0N2N0WV6 / lycopene
  • [Other-IDs] NLM/ NIHMS80794; NLM/ PMC2597727
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13. Ardiansyah, Shirakawa H, Koseki T, Ohinata K, Hashizume K, Komai M: Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats. J Agric Food Chem; 2006 Mar 8;54(5):1914-20
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  • Male 4-week-old rats were divided into one group fed the AIN-93M-based control (C) diet and two groups fed diet supplemented with 60 g/kg of Driselase and ethanol fractions (DF and EF, respectively) of rice bran.

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  • [ErratumIn] J Agric Food Chem. 2006 Nov 29;54(24):9277
  • (PMID = 16506853.001).
  • [ISSN] 0021-8561
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Fungal Proteins; 0 / Lipids; 31C4KY9ESH / Nitric Oxide; 3K9958V90M / Ethanol; 632XD903SP / Gallic Acid; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; 8R1V1STN48 / Catechin; EC 3.2.1.- / Glycoside Hydrolases; EC 3.2.1.- / driselase; G9481N71RO / Deoxyguanosine
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14. Pantanowitz L, Leiman G, Dezube BJ: Editorial comment: screening for anal dysplasia--are we on the same page? AIDS Read; 2009 May;19(5):182-3
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  • [Title] Editorial comment: screening for anal dysplasia--are we on the same page?
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. HIV Infections / diagnosis. Mass Screening. Precancerous Conditions / diagnosis
  • [MeSH-minor] Anal Canal / pathology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / prevention & control. Humans. Male. Washington / epidemiology

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  • [CommentOn] AIDS Read. 2009 May;19(5):178-86 [19554736.001]
  • (PMID = 19554737.001).
  • [ISSN] 1053-0894
  • [Journal-full-title] The AIDS reader
  • [ISO-abbreviation] AIDS Read
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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15. Iwao K, Inatani M, Ogata-Iwao M, Takihara Y, Tanihara H: Restricted post-trabeculectomy bleb formation by conjunctival scarring. Graefes Arch Clin Exp Ophthalmol; 2009 Aug;247(8):1095-101
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  • The area and the height of the bleb in the conjunctivae with radial incision (Ain and Hin, respectively) were compared with the area and the height of the bleb in the conjunctivae without radial incision (Ano and Hno, respectively).
  • We compared the parameters of bleb area (total bleb area, Ain and Ano) and bleb height (the bleb height at the centre of the scleral flap; Hc, Hin and Hno) in eyes without previous ocular surgeries, with those in eyes that underwent previous ocular surgeries.
  • The Ano and the Hno were significantly larger than the Ain (p < 0.001) and the Hin (p < 0.001) respectively.
  • Subgroup analyses in eyes without previous ocular surgeries and eyes with phacoemulsification cataract surgery also showed that the Ano was significantly larger than the Ain.
  • However, there was no significant difference between the Ano and the Ain in eyes with previous trabeculectomy.
  • By contrast, the total bleb area (p = 0.021), the Ano (p = 0.017) and the Hc (p = 0.045) were significantly smaller in eyes with previous trabeculectomy than in eyes without previous ocular surgeries.

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  • (PMID = 19214551.001).
  • [ISSN] 1435-702X
  • [Journal-full-title] Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
  • [ISO-abbreviation] Graefes Arch. Clin. Exp. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antimetabolites; U3P01618RT / Fluorouracil
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16. Hammell M, Long D, Zhang L, Lee A, Carmack CS, Han M, Ding Y, Ambros V: mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nat Methods; 2008 Sep;5(9):813-9
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  • Recently, a dataset of 3,404 miRNA-associated mRNA transcripts was identified by immunoprecipitation of the RNA-induced silencing complex components AIN-1 and AIN-2.
  • Our analysis of this AIN-IP dataset revealed enrichment for defining characteristics of functional miRNA-target interactions, including structural accessibility of target sequences, total free energy of miRNA-target hybridization and topology of base-pairing to the 5' seed region of the miRNA.
  • We used these enriched characteristics as the basis for a quantitative miRNA target prediction method, miRNA targets by weighting immunoprecipitation-enriched parameters (mirWIP), which optimizes sensitivity to verified miRNA-target interactions and specificity to the AIN-IP dataset.

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  • (PMID = 19160516.001).
  • [ISSN] 1548-7091
  • [Journal-full-title] Nature methods
  • [ISO-abbreviation] Nat. Methods
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM047869; United States / NIGMS NIH HHS / GM / R01 GM068726; United States / NIGMS NIH HHS / GM / R01 GM066826; United States / NIGMS NIH HHS / GM / GM34028; United States / NIGMS NIH HHS / GM / GM47869; United States / Howard Hughes Medical Institute / / ; United States / NIGMS NIH HHS / GM / GM034028-25A2; United States / NIGMS NIH HHS / GM / R01 GM034028; United States / NIGMS NIH HHS / GM / R01 GM034028-25A2; United States / NIGMS NIH HHS / GM / GM068726; United States / NIGMS NIH HHS / GM / GM066826
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AIN-1 protein, C elegans; 0 / Carrier Proteins; 0 / MicroRNAs; 0 / RNA, Messenger; 0 / Ribonucleoproteins
  • [Other-IDs] NLM/ NIHMS290397; NLM/ PMC3092588
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17. Czoski-Murray C, Karnon J, Jones R, Smith K, Kinghorn G: Cost-effectiveness of screening high-risk HIV-positive men who have sex with men (MSM) and HIV-positive women for anal cancer. Health Technol Assess; 2010 Nov;14(53):iii-iv, ix-x, 1-101
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  • [Title] Cost-effectiveness of screening high-risk HIV-positive men who have sex with men (MSM) and HIV-positive women for anal cancer.
  • BACKGROUND: Anal cancer is uncommon and predominantly a disease of the elderly.
  • Individuals who are human immunodeficiency virus (HIV)-positive are particularly vulnerable to HPV infections, and increasing numbers from this population present with anal cancer.
  • OBJECTIVE: To estimate the cost-effectiveness of screening for anal cancer in the high-risk HIV-positive population [in particular, men who have sex with men (MSM), who have been identified as being at greater risk of the disease] by developing a model that incorporates the national screening guidelines criteria.
  • Papers that met the inclusion criteria contained the following: data on population incidence, effectiveness of screening, health outcomes or screening and/or treatment costs; defined suitable screening technologies; prospectively evaluated tests to detect anal cancer.
  • RESULTS: The reference case cost-effectiveness model for MSM found that screening for anal cancer is very unlikely to be cost-effective.
  • The negative aspects of screening included utility decrements associated with false-positive results and with treatment for high-grade anal intraepithelial neoplasia (HG-AIN).
  • However, combined with higher regression rates from low-grade anal intraepithelial neoplasia (LG-AIN), the lowest expected incremental cost-effectiveness ratio remained at over 44,000 pounds per quality-adjusted life-year (QALY) gained.
  • LIMITATIONS: Limited knowledge is available about the epidemiology and natural history of anal cancer, along with a paucity of good-quality evidence concerning the effectiveness of screening.
  • Further studies could assess whether the screening model has underestimated the impact of anal cancer, the results of which may justify an evaluative study of the effects of treatment for HG-AIN.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / economics. HIV Infections / complications. Homosexuality, Male / statistics & numerical data. Mass Screening / economics


18. Darvishian F, Stier EA, Soslow RA, Lin O: Immunoreactivity of p16 in anal cytology specimens: histologic correlation. Cancer; 2006 Feb 25;108(1):66-71
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  • [Title] Immunoreactivity of p16 in anal cytology specimens: histologic correlation.
  • BACKGROUND: Cytology has been proposed as a potential screening tool in the evaluation of squamous anorectal disease in view of the morphologic similarities between anal and cervical squamous lesions.
  • Previous studies have demonstrated that p16 overexpression correlates with the degree of dysplasia in the uterine cervix with promising results.
  • Due to potential diagnostic pitfalls in anal cytology, p16 overexpression in these specimens was studied.
  • RESULTS: Twenty-eight of the 43 cases demonstrated the presence of squamous cells immunoreactive for p16 in cytology specimens.
  • The p16-positive cells were identified in cases of low-grade squamous intraepithelial lesion (LSIL) (n = 3 cases), high-grade squamous intraepithelial lesion (HSIL) (n = 22 cases), and invasive squamous carcinoma (n = 1 case), and in 2 cases with negative follow-up biopsies.
  • The sensitivity and specificity of p16 immunoreactivity in the detection of anal intraepithelial neoplasia or carcinoma were 72% and 71%, respectively.
  • CONCLUSIONS: The presence of p16 immunoreactivity is a good predictor of dysplasia in anal specimens.
  • [MeSH-major] Anus Neoplasms / pathology. Biomarkers, Tumor / analysis. Carcinoma in Situ / pathology. Neoplasms, Squamous Cell / pathology

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 16404747.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16
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19. Abou-Saleh MT: Substance use disorders: Recent advances in treatment and models of care. J Psychosom Res; 2006 Sep;61(3):305-10
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  • Community surveys in Dubai and Al-Ain have shown a high prevalence of these disorders.

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  • (PMID = 16938506.001).
  • [ISSN] 0022-3999
  • [Journal-full-title] Journal of psychosomatic research
  • [ISO-abbreviation] J Psychosom Res
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 16
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20. Rahman MM, Bhattacharya A, Banu J, Kang JX, Fernandes G: Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis. J Cell Mol Med; 2009 Aug;13(8B):1833-44
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  • Beneficial effects of n-3 fatty acids (FA) on bone mineral density (BMD) have been reported in mice, rats and human beings, but the precise mechanisms involved have not been described.
  • Ovariectomized (Ovx) and sham operated wild-type (WT) and Fat-1 mice were fed an AIN-93M diet containing 10% corn oil for 24 weeks.

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  • (PMID = 20141608.001).
  • [ISSN] 1582-4934
  • [Journal-full-title] Journal of cellular and molecular medicine
  • [ISO-abbreviation] J. Cell. Mol. Med.
  • [Language] eng
  • [Grant] United States / NCCIH NIH HHS / AT / R01 AT004259; United States / NIA NIH HHS / AG / R01 AG030161; United States / NCCIH NIH HHS / AT / R01 AT004259-02; United States / NIA NIH HHS / AG / R01 AG023648; United States / NIA NIH HHS / AG / R01 AG030161-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fatty Acids, Omega-3
  • [Other-IDs] NLM/ NIHMS152354; NLM/ PMC2855756
  • [Keywords] NOTNLM ; bone mineral density / inflammation / n-3 fatty acids / osteoclasts / osteoporosis
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21. Rajakangas J, Misikangas M, Päivärinta E, Mutanen M: Chemoprevention by white currant is mediated by the reduction of nuclear beta-catenin and NF-kappaB levels in Min mice adenomas. Eur J Nutr; 2008 Apr;47(3):115-22
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  • METHODS: Multiple intestinal neoplasia (Min) mice were fed an AIN-93G based control diet or a diet containing 10% freeze dried white currant (Ribes x pallidum) for 10 weeks.

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  • (PMID = 18389329.001).
  • [ISSN] 1436-6207
  • [Journal-full-title] European journal of nutrition
  • [ISO-abbreviation] Eur J Nutr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / NF-kappa B; 0 / beta Catenin
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22. Bebe FN, Panemangalore M: Pesticides and essential minerals modify endogenous antioxidants and cytochrome P450 in tissues of rats. J Environ Sci Health B; 2005;40(5):769-84
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  • In both experiments, six rats/group were fed diets based on the AIN-93M diet (Control) or the same modified to contain either 500 mg calcium (Low Ca), 7 mg Zn (Low Zn): 2 mg copper (Low Cu), 60 mg zinc (High Zn) or 12 mg copper (High Cu) in the following combination: Control, LCa/LZn, LCa/LZn/LCu, or HZn/HCu, with and without a pesticide mixture containing acephate, endosulfan, and thiram at 25% LD50 for four or two weeks.

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  • (PMID = 16190021.001).
  • [ISSN] 0360-1234
  • [Journal-full-title] Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes
  • [ISO-abbreviation] J Environ Sci Health B
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pesticides; 9035-51-2 / Cytochrome P-450 Enzyme System; EC 1.11.1.9 / Glutathione Peroxidase; EC 1.15.1.1 / Superoxide Dismutase; GAN16C9B8O / Glutathione
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23. El Samny T, El Halaby H, El Fiky L, Nassar M, El Makhzangy A, Eissa S: Prognostic value of telomerase and DNA ploidy in laryngeal carcinoma. Eur Arch Otorhinolaryngol; 2005 Oct;262(10):799-803
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  • The work was carried out as a prospective observational study that included 35 patients with laryngeal carcinoma who were treated surgically at Ain Shams University Hospitals, Cairo, Egypt.
  • [MeSH-major] DNA, Neoplasm / analysis. Laryngeal Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Telomerase / analysis

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  • (PMID = 15739089.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
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  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / RNA, Messenger; EC 2.7.7.49 / Telomerase
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24. Hampl M, Wentzensen N, Vinokurova S, von Knebel-Doeberitz M, Poremba C, Bender HG, Kueppers V: Comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by HPV typing and p16 expression profile. J Cancer Res Clin Oncol; 2007 Apr;133(4):235-45
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  • [Title] Comprehensive analysis of 130 multicentric intraepithelial female lower genital tract lesions by HPV typing and p16 expression profile.
  • METHODS: One hundred and thirty biopsies of 52 women treated for multicentric synchronous or metachronous lower genital tract intraepithelial neoplasias were collected.
  • HPV16 was frequently found in VIN, VaIN and AIN (73, 60 and 77%, respectively), whereas only 37% of CIN were HPV16 positive.
  • [MeSH-major] Biomarkers, Tumor. Cervical Intraepithelial Neoplasia / virology. Genital Neoplasms, Female / virology. Papillomaviridae / classification. Papillomavirus Infections / virology. Polymerase Chain Reaction / methods
  • [MeSH-minor] Adult. Anus Neoplasms / diagnosis. Anus Neoplasms / genetics. Anus Neoplasms / pathology. Anus Neoplasms / virology. Colposcopy. DNA Primers. DNA, Viral / classification. DNA, Viral / genetics. DNA, Viral / isolation & purification. Female. Gene Expression Regulation, Neoplastic. Gene Expression Regulation, Viral. Genes, p16. Human papillomavirus 16 / genetics. Human papillomavirus 16 / isolation & purification. Humans. Middle Aged. Precancerous Conditions / diagnosis. Precancerous Conditions / genetics. Precancerous Conditions / pathology. Precancerous Conditions / virology. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / genetics. Uterine Cervical Neoplasms / pathology. Uterine Cervical Neoplasms / virology. Vaginal Neoplasms / diagnosis. Vaginal Neoplasms / genetics. Vaginal Neoplasms / pathology. Vaginal Neoplasms / virology. Vulvar Neoplasms / diagnosis. Vulvar Neoplasms / genetics. Vulvar Neoplasms / pathology. Vulvar Neoplasms / virology

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  • (PMID = 17294241.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA Primers; 0 / DNA, Viral
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25. Casino P, Niks D, Ngo H, Pan P, Brzovic P, Blumenstein L, Barends TR, Schlichting I, Dunn MF: Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding. Biochemistry; 2007 Jul 3;46(26):7728-39
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  • Here we employ the chromophoric l-Trp analogue, trans-3-indole-3'-acrylate (IA), and noncleavable alpha-site ligands (ASLs) to probe the allosteric properties of the internal aldimine, E(Ain).
  • The ASLs studied are alpha-d,l-glycerol phosphate (GP) and d-glyceraldehyde 3-phosphate (G3P), and examples of two new classes of high-affinity alpha-site ligands, N-(4'-trifluoromethoxybenzoyl)-2-aminoethyl phosphate (F6) and N-(4'-trifluoromethoxybenzenesulfonyl)-2-aminoethyl phosphate (F9), that were previously shown to bind to the alpha-site by optical spectroscopy and X-ray crystal structures [Ngo, H., Harris, R., Kimmich, N., Casino, P., Niks, D., Blumenstein, L., Barends, T.
  • The binding of ASLs was found to increase the affinity of the beta-site of E(Ain) for IA by 4-5-fold, demonstrating for the first time that the beta-subunit of the E(Ain) species undergoes a switching between low- and high-affinity states in response to the binding of ASLs.

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  • (PMID = 17559231.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM55749
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indoles; 83X500J040 / indoleacrylic acid; EC 4.2.1.20 / Tryptophan Synthase
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26. Barnard DE, Lewis SM, Teter BB, Thigpen JE: Open- and closed-formula laboratory animal diets and their importance to research. J Am Assoc Lab Anim Sci; 2009 Nov;48(6):709-13
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  • During the 1970s, the American Institute of Nutrition, National Academy of Science, Institute of Laboratory Animal Resources, and Laboratory Animals Centre Diets Advisory Committee supported the use of 'standard reference diets' in biomedical research as a means to improve the ability to replicate research.
  • [MeSH-major] Animal Feed / standards. Animal Husbandry / standards. Animal Nutrition Sciences / standards. Animals, Laboratory / physiology. Biomedical Research / standards. Food, Formulated / standards

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  • (PMID = 19930817.001).
  • [ISSN] 1559-6109
  • [Journal-full-title] Journal of the American Association for Laboratory Animal Science : JAALAS
  • [ISO-abbreviation] J. Am. Assoc. Lab. Anim. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2786923
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27. Femia AP, Dolara P, Servili M, Esposto S, Taticchi A, Urbani S, Giannini A, Salvadori M, Caderni G: No effects of olive oils with different phenolic content compared to corn oil on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Eur J Nutr; 2008 Sep;47(6):329-34
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  • METHODS: F344 rats were fed AIN-76 based diets for the entire experimental period; the diets contained 23% (w/w) of lipids from three different sources: extra-virgin olive oil rich in phenolic compounds (EV), rectified olive oil (ROO) with the same fatty acid composition but devoid of phenolic compounds and CO as a control diet.

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  • (PMID = 18677543.001).
  • [ISSN] 1436-6215
  • [Journal-full-title] European journal of nutrition
  • [ISO-abbreviation] Eur J Nutr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Olive Oil; 0 / Phenols; 0 / Plant Oils; 8001-30-7 / Corn Oil; IX068S9745 / 1,2-Dimethylhydrazine
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28. Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RC: The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis; 2005 Oct;26(10):1793-803
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  • [Title] The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.
  • This study evaluated the mechanism by which diets containing GEN promote mammary epithelial cell death.
  • We report that mammary glands of young adult female rats exposed from gestation day 4 to postnatal day 50, to AIN-93G diets containing as sole protein source, casein (CAS) supplemented with GEN, or soy protein isolate (SPI+) had increased apoptosis, relative to rats fed CAS diet devoid of GEN.
  • [MeSH-major] Apoptosis / drug effects. Epithelial Cells / cytology. Genistein / pharmacology. Mammary Glands, Animal / cytology. Phosphoric Monoester Hydrolases / genetics. Prenatal Exposure Delayed Effects. Tumor Suppressor Proteins / genetics

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  • (PMID = 15905199.001).
  • [ISSN] 0143-3334
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / DNA Primers; 0 / Tumor Suppressor Proteins; DH2M523P0H / Genistein; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
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29. Ding L, Spencer A, Morita K, Han M: The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell; 2005 Aug 19;19(4):437-47
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  • [Title] The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans.
  • We have identified the C. elegans ain-1 gene through a genetic suppressor screen and shown that it functions with the heterochronic genetic pathway that regulates developmental timing.
  • Biochemical analysis indicates that AIN-1 interacts with protein complexes containing an Argonaute protein, Dicer, and miRNAs.
  • AIN-1 shares homology with the candidate human neurological disease protein GW182, shown to localize in cytoplasmic processing bodies that are sites of mRNA degradation and storage.
  • A functional AIN-1::GFP also localizes at the likely worm processing bodies.
  • When coexpressed from transgenes, AIN-1 targets ALG-1 to the foci.
  • These results suggest a model where AIN-1 regulates a subset of miRISCs by localization to the processing bodies, facilitating degradation or translational inhibition of mRNA targets.

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  • (PMID = 16109369.001).
  • [ISSN] 1097-2765
  • [Journal-full-title] Molecular cell
  • [ISO-abbreviation] Mol. Cell
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AAK32947
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AIN-1 protein, C elegans; 0 / ALG-1 protein, C elegans; 0 / Caenorhabditis elegans Proteins; 0 / Carrier Proteins; 0 / MicroRNAs; 0 / RNA-Binding Proteins; EC 3.1.- / Endoribonucleases; EC 3.1.26.- / dcr-1 protein, C elegans; EC 3.1.26.3 / Ribonuclease III
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30. Saleh NK, Saleh HA: Protective effects of vitamin E against myocardial ischemia/reperfusion injury in rats. Saudi Med J; 2010 Feb;31(2):142-7
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  • METHODS: This randomized control study was conducted in the Physiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt from 1st June to 31 August 2009.

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  • [ErratumIn] Saudi Med J. 2010 Apr;31(4):466
  • (PMID = 20174728.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 1406-18-4 / Vitamin E
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31. Dash N, Ameen AS, Sheek-Hussein MM, Smego RA Jr: Epidemiology of meningitis in Al-Ain, United Arab Emirates, 2000-2005. Int J Infect Dis; 2007 Jul;11(4):309-12
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  • [Title] Epidemiology of meningitis in Al-Ain, United Arab Emirates, 2000-2005.
  • OBJECTIVE: To describe the epidemiologic features of meningitis in Al-Ain Medical District, United Arab Emirates from January 2000 through June 2005.
  • METHODS: A retrospective review of clinical records and notification forms for cases of meningitis reported to the Department of Preventive Medicine, Al-Ain.
  • The incidence rate of meningitis in Al-Ain ranged between 2.2/100,000 population in 2000 and 1/100,000 in 2005, with an overall downward trend by year.

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  • (PMID = 16950640.001).
  • [ISSN] 1201-9712
  • [Journal-full-title] International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • [ISO-abbreviation] Int. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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32. Gańczak M, Barss P, Alfaresi F, Almazrouei S, Muraddad A, Al-Maskari F: Break the silence: HIV/AIDS knowledge, attitudes, and educational needs among Arab university students in United Arab Emirates. J Adolesc Health; 2007 Jun;40(6):572.e1-8
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  • METHODS: A cross-sectional survey among randomly selected first-year, gender-segregated Arab students at the national university in Al Ain in 2005 was conducted using an adaptation of an anonymous self-administered World Health Organization questionnaire.

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  • (PMID = 17531765.001).
  • [ISSN] 1879-1972
  • [Journal-full-title] The Journal of adolescent health : official publication of the Society for Adolescent Medicine
  • [ISO-abbreviation] J Adolesc Health
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Eason RR, Till SR, Frank JA, Badger TM, Korourian S, Simmen FA, Simmen RC: Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis. Nutr Cancer; 2006;55(2):171-7
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  • [Title] Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis.
  • In a 7,12-dimethylbenz(a)anthracene-induced model of carcinogenesis, we showed previously that female Sprague-Dawley rats exposed to AIN-93G diet containing whey protein hydrolysate (WPH) beginning at gestation Day 4 had reduced tumor incidence than those exposed to diet containing casein (CAS), due partly to increased mammary differentiation and reduced activity of phase I metabolic enzymes.


34. Stratta P, Canavese C, Fenoglio R, Priolo G, Grillo A, Aimo G, Quaglia M, Pagni R: Dual effect of methylprednsolone pulses on apoptosis of peripheral leukocytes in patients with renal diseases. Int J Immunopathol Pharmacol; 2006 Jul-Sep;19(3):647-59
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  • We studied the in vivo effects of steroids by oral assumption (10 to 25 mg/deltacortene) or by intravenous pulses (300 to 1000 mg/dose) on apoptosis and cellular subsets of peripheral lymphocytes, by evaluating DNA-fragmentation and lymphocyte subsets in 79 subjects: 22 controls and 57 patients with various renal diseases (25 Lupus-GN, 19 membranous-GN (MGN), 6 rapidly progressive-GN (RPGN), 2 acute interstitial nephritis (AIN), 5 on chronic dialysis.

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  • (PMID = 17026850.001).
  • [ISSN] 0394-6320
  • [Journal-full-title] International journal of immunopathology and pharmacology
  • [ISO-abbreviation] Int J Immunopathol Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD3; X4W7ZR7023 / Methylprednisolone
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35. Eason RR, Till SR, Velarde MC, Geng Y, Chatman L Jr, Gu L, Badger TM, Simmen FA, Simmen RC: Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. J Nutr Biochem; 2005 Oct;16(10):625-32
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  • Here, we evaluated intermediate markers of cancer risk in uteri of cycling, young adult Sprague-Dawley rats lifetime exposed to one of three AIN-93G semipurified diets: casein (CAS), soy protein isolate (SPI+ with 276 mg GEN aglycone equivalents/kg) and CAS+GEN (GEN at 250 mg/kg).

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  • (PMID = 16081271.001).
  • [ISSN] 0955-2863
  • [Journal-full-title] The Journal of nutritional biochemistry
  • [ISO-abbreviation] J. Nutr. Biochem.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / HD21961
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caseins; 0 / Estrogens; 0 / Proliferating Cell Nuclear Antigen; 0 / Soybean Proteins; 4G7DS2Q64Y / Progesterone; 4TI98Z838E / Estradiol; DH2M523P0H / Genistein
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36. Stier EA, Baranoski AS: Human papillomavirus-related diseases in HIV-infected individuals. Curr Opin Oncol; 2008 Sep;20(5):541-6
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  • RECENT FINDINGS: Studies assessing geographic variations in human papillomavirus types and prevalence in cervical dysplasia and cancer in HIV-infected women suggest that although human papillomavirus types 16 and 18 dominate, multiple other human papillomavirus types may play a role in carcinogenesis.
  • Anal dysplasia and cancer incidence continues to rise in the highly active antiretroviral therapy era; however, data on outcomes following therapy for anal dysplasia (infrared coagulator, high-resolution anoscopy-guided ablation) and anal cancer (chemoradiation and possibly intensity-modulated radiation therapy) have been encouraging.
  • SUMMARY: As HIV-infected patients in the highly active antiretroviral therapy era continue to have high rates of cervical and anal cancer, it is important to continue screening efforts and treatment of preinvasive disease.
  • Treatment options for anal dysplasia and anal cancer in HIV-infected individuals are expanding and may lead to decreased morbidity and mortality.

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  • (PMID = 19106657.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01 CA121947; United States / NCI NIH HHS / CA / U01 CA121947-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 49
  • [Other-IDs] NLM/ NIHMS126311; NLM/ PMC2757652
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37. Membrilla-Fernández E, Parés D, Alameda F, Pascual M, Courtier R, Gil MJ, Vallecillo G, Fusté P, Pera M, Grande L: [Anal intraepithelial neoplasia: application of a diagnostic protocol in risk patients using anal cytology]. Cir Esp; 2009 Jun;85(6):365-70
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  • [Title] [Anal intraepithelial neoplasia: application of a diagnostic protocol in risk patients using anal cytology].
  • [Transliterated title] Neoplasia intraepitelial anal: resultados de la aplicación de un protocolo diagnóstico en pacientes de riesgo mediante el uso de citología anal.
  • INTRODUCTION: Anal intraepithelial neoplasia is a precursor condition of squamous anal carcinoma.
  • The groups at risk of this lesion are patients with anogenital condylomata, cervical dysplasia, human immunodeficiency virus infection and, in general, patients with HPV infection.
  • The aim of this study was to analyse the results of a diagnostics protocol of Anal Intraepithelial Neoplasia in high risk population using anal cytology.
  • PATIENTS AND METHOD: The protocol is based on a visit in the outpatient department, clinical interview, physical examination and anal cytology evaluated by Bethesda criteria.
  • The cross-sectional observational study was designed to study the anal smear results and their relationship with risk factors.
  • In the overall series, 25 patients have been diagnosed with abnormal anal cytology: 9 atypical squamous cells of undetermined significance (ASCUS), 15 low-grade and 1 high-grade squamous intraepithelial lesions.
  • There were no significant associations between abnormal cytology results and the presence of anal condyloma (p = 0.22).
  • CONCLUSIONS: Our diagnostic protocol of anal intraepithelial neoplasia revealed 25% of patients with pre-invasive lesions of squamous anal cancer.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology

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  • (PMID = 19303590.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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38. Tou JC, Arnaud SB, Grindeland R, Wade C: The effect of purified compared with nonpurified diet on bone changes induced by hindlimb suspension of female rats. Exp Biol Med (Maywood); 2005 Jan;230(1):31-9
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  • Female Sprague-Dawley rats were fed a purified American Institute of Nutrition (AIN) 93G diet or a standard nonpurified diet and kept ambulatory or subjected to unloading by hindlimb suspension (HLS) for 38 days.
  • The HLS-induced decrease in femoral BMC was not statistically different for rats fed a nonpurified diet (-8.6%) compared with a purified AIN-93G diet (-11.4%).
  • The HLS-induced decrease in femoral mechanical strength was not statistically different for rats fed a nonpurified diet (-24%) compared with a purified AIN-93G diet (-31%).
  • Plasma estradiol levels were lower (P < 0.05) in the HLS/AIN-93G group but similar in the HLS and ambulatory rats fed a nonpurified diet.
  • Urinary calcium excretion was higher (P < 0.05) in rats fed a nonpurified diet than those fed a purified AIN-93G diet, which is consistent with the higher level of calcium in the nonpurified diet.
  • Urinary corticosterone levels were higher (P < 0.05) in rats fed a nonpurified diet than rats fed the AIN-93G diet.

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  • (PMID = 15618123.001).
  • [ISSN] 1535-3702
  • [Journal-full-title] Experimental biology and medicine (Maywood, N.J.)
  • [ISO-abbreviation] Exp. Biol. Med. (Maywood)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Keywords] NASA ; NASA Center ARC / NASA Discipline Regulatory Physiology
  • [Investigator] Wade CE
  • [General-notes] NASA/ Grant numbers: NASA 121-10-30, NASA 121-10-40, NASA 121-10-50, NASA NAG9-1162.
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39. Eckert L: Screening for anal dysplasia in women with cervical, vaginal, or vulvar dysplasia: yes, no, maybe? Obstet Gynecol; 2010 Sep;116(3):566-7
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  • [Title] Screening for anal dysplasia in women with cervical, vaginal, or vulvar dysplasia: yes, no, maybe?
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Genital Neoplasms, Female / complications

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  • [CommentOn] Obstet Gynecol. 2010 Sep;116(3):578-82 [20733438.001]
  • (PMID = 20733435.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] United States
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40. Ju YH, Doerge DR, Woodling KA, Hartman JA, Kwak J, Helferich WG: Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo. Carcinogenesis; 2008 Nov;29(11):2162-8
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  • In this study, we evaluated the interaction of dietary GEN (at 250-1000 p.p.m. in the American Institute of Nutrition 93 growth diet) and an aromatase inhibitor, letrozole (LET), on the growth of tumors in an aromatase-expressing breast cancer xenograft model (MCF-7Ca) in the presence and absence of the substrate androstenedione (AD).

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  • Hazardous Substances Data Bank. LETROZOLE .
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  • (PMID = 18632754.001).
  • [ISSN] 1460-2180
  • [Journal-full-title] Carcinogenesis
  • [ISO-abbreviation] Carcinogenesis
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA77355; United States / NIA NIH HHS / AG / P01 AG024387
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aromatase Inhibitors; 0 / DNA Primers; 0 / Nitriles; 0 / Triazoles; 4TI98Z838E / Estradiol; 7LKK855W8I / letrozole; DH2M523P0H / Genistein; EC 1.14.14.1 / Aromatase
  • [Other-IDs] NLM/ PMC2722859
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41. Palefsky J: Human papillomavirus and anal neoplasia. Curr HIV/AIDS Rep; 2008 May;5(2):78-85
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  • [Title] Human papillomavirus and anal neoplasia.
  • Anal cancer is a rare disease in the general population, but the incidence of anal cancer is higher in certain at-risk groups, such as men who have sex with men (MSM), and immunosuppressed individuals, including those with HIV infection.
  • Among HIV-positive MSM, the incidence of anal cancer may be as high as 10 times greater than current rates of cervical cancer in the general population of women.
  • Anal cancer is associated with human papillomavirus (HPV) infection and may be preceded by high-grade anal intraepithelial neoplasia (HGAIN).
  • HGAIN and anal HPV infection are both highly prevalent in groups at risk for anal cancer.
  • Current issues include determining the effect of antiretroviral therapy on the natural history of HGAIN and the incidence of anal cancer, optimizing diagnostic and therapeutic approaches to HGAIN, and determining the potential for prophylactic HPV vaccines to prevent anal HPV infection and anal cancer in at-risk groups.
  • [MeSH-major] Anus Neoplasms. Carcinoma in Situ. Papillomavirus Infections
  • [MeSH-minor] Anus Diseases / epidemiology. Anus Diseases / virology. Female. HIV Infections / complications. Homosexuality, Male. Humans. Male. Papillomaviridae / isolation & purification

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  • (PMID = 18510893.001).
  • [ISSN] 1548-3568
  • [Journal-full-title] Current HIV/AIDS reports
  • [ISO-abbreviation] Curr HIV/AIDS Rep
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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42. Wang N, Qi M, Liang SR: [Protective effects of Paecilomyces hepiali Cs-4 on rats with adriamycin-induced nephropathy]. Zhongguo Zhong Xi Yi Jie He Za Zhi; 2010 Sep;30(9):957-60
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  • OBJECTIVE: To study the renal protective effect of Paecilomyces hepiali Cs-4 (Abbr. to Cs-4) on rats with adriamycin-induced nephropathy (AIN).
  • AIN rat model was established by left unilateral nephrectomy and repeated caudal vein injection of adriamycin.
  • RESULTS: Levels of 24h-UP, BUN, Scr, mesengial matrix percentage, as well OPN, FN, COL-IV were significantly lower in group D than in group B (P < 0.05); and the fat metabolic disorder was improved in group D (P < 0.05).
  • CONCLUSION: Cs-4 displays its renal protective action in rats with AIN through reducing the urinary protein excretion, correcting lipid metabolic disturbance, inhibiting the over accumulation of extracellular matrix, improving the pathological damage of kidney, thus restoring the renal function.

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  • (PMID = 21179737.001).
  • [ISSN] 1003-5370
  • [Journal-full-title] Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • [ISO-abbreviation] Zhongguo Zhong Xi Yi Jie He Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Materia Medica; 0 / Protective Agents; 80168379AG / Doxorubicin
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43. Kozul CD, Nomikos AP, Hampton TH, Warnke LA, Gosse JA, Davey JC, Thorpe JE, Jackson BP, Ihnat MA, Hamilton JW: Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem Biol Interact; 2008 May 28;173(2):129-40
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  • C57BL/6J mice were raised for 5 weeks on either the cereal-based, non-purified LRD-5001 diet or the purified, casein-based AIN-76A diet, as part of a larger study examining the effects of low dose arsenic (As) in the diet or drinking water.
  • The LRD-5001 diet masked the As-induced gene expression changes that were clearly seen in the animals fed the AIN-76A diet when each dietary group was exposed to 100 ppb As in drinking water.
  • Trace metal analysis revealed that the LRD-5001 diet contained a mixture of inorganic and organic As at a total concentration of 390 ppb, while the AIN-76A diet contained approximately 20 ppb.


44. Dwivedi C, Natarajan K, Matthees DP: Chemopreventive effects of dietary flaxseed oil on colon tumor development. Nutr Cancer; 2005;51(1):52-8
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  • Male Fischer rats, separated into 2 groups of 30, were assigned to the AIN-93M diet, which was supplemented with either 15% corn oil or 15% flaxseed oil.

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  • (PMID = 15749630.001).
  • [ISSN] 0163-5581
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats, Unsaturated; 0 / Fatty Acids, Omega-3; 0 / Fatty Acids, Omega-6; 8001-26-1 / Linseed Oil; 8001-30-7 / Corn Oil; MO0N1J0SEN / Azoxymethane
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45. Lu X, Miyachi S, Ito Y, Nambu A, Takada M: Topographic distribution of output neurons in cerebellar nuclei and cortex to somatotopic map of primary motor cortex. Eur J Neurosci; 2007 Apr;25(8):2374-82
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  • At 3 days after rabies injections into proximal forelimb, distal forelimb and hindlimb representations of the macaque MI, second-order neurons via the thalamus were labeled in the deep cerebellar nuclei, including the dentate (DN), anterior interpositus (AIN) and posterior interpositus nuclei.
  • The same rostrocaudal arrangement was observed in the AIN.
  • These results indicate that the hindlimb, proximal forelimb and distal forelimb are arranged rostrocaudally in the DN and AIN, whereas there is dual somatotopy along the rostrocaudal and lateromedial axes in the cerebellar cortex.

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  • (PMID = 17445235.001).
  • [ISSN] 0953-816X
  • [Journal-full-title] The European journal of neuroscience
  • [ISO-abbreviation] Eur. J. Neurosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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46. Stier EA, Goldstone SE, Berry JM, Panther LA, Jay N, Krown SE, Lee J, Palefsky JM: Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study. J Acquir Immune Defic Syndr; 2008 Jan 1;47(1):56-61
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  • [Title] Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study.
  • OBJECTIVE: To evaluate prospectively the safety of the infrared coagulator (IRC) as a treatment for anal high-grade squamous intraepithelial lesions (HSILs) in HIV-infected individuals and to seek preliminary evidence for efficacy.
  • METHODS: HIV-infected patients with </=3 biopsy-proven internal anal HSILs received office-based treatment with the IRC at participating AIDS Malignancy Consortium sites.
  • Patients were evaluated every 3 months for a year with anal cytology and HRA with biopsy.
  • Twelve patients reported mild or moderate anal/rectal pain or bleeding.
  • CONCLUSIONS: The IRC is a well-tolerated method of treating discrete anal canal HSILs in HIV-infected patients.
  • [MeSH-major] Anus Neoplasms / therapy. HIV Infections / complications. Infrared Rays. Phototherapy. Precancerous Conditions / therapy

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  • (PMID = 18156992.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / U01CA070047; United States / NCI NIH HHS / CA / U01CA071375; United States / NCI NIH HHS / CA / U01CA121947; United States / NCI NIH HHS / CA / U01CA70019; United States / NCI NIH HHS / CA / U01CA70054
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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47. Yang K, Fan KH, Lamprecht SA, Edelmann W, Kopelovich L, Kucherlapati R, Lipkin M: Peroxisome proliferator-activated receptor gamma agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in Apc1638 N/+ Mlh1+/- double mutant mice. Int J Cancer; 2005 Sep 10;116(4):495-9
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  • Our study was designed to determine whether troglitazone (TGZ) induces colonic tumor formation in normal C57BL/6J mice and enhances colorectal carcinogenesis in double mutant Apc1638N/+ Mlh1+/- mice fed a standard AIN-76A diet.

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15818612.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-15116; United States / NCI NIH HHS / CA / U01-CA-84301; United States / NIEHS NIH HHS / ES / U01-ES-11040
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Antineoplastic Agents; 0 / Carcinogens; 0 / Carrier Proteins; 0 / Chromans; 0 / MLH1 protein, human; 0 / Mlh1 protein, mouse; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / PPAR gamma; 0 / Thiazolidinediones; I66ZZ0ZN0E / troglitazone
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48. Walts AE, Thomas P, Bose S: Anal cytology: is there a role for reflex HPV DNA testing? Diagn Cytopathol; 2005 Sep;33(3):152-6
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  • [Title] Anal cytology: is there a role for reflex HPV DNA testing?
  • There is an increased incidence of anal squamous carcinoma and its precursor lesions (anal intraepithelial neoplasia [AIN]) among persons who engage in anal-receptive sex.
  • Analogous to cervical cancer screening, anal Papanicplaou (Pap) smears currently are used to screen these high-risk populations.
  • Human papilloma virus (HPV) has been implicated in anal carcinoma pathogenesis and this study was performed to assess the potential role of HPV DNA testing as an adjunct to anal cytology.
  • We correlated cytological diagnoses and HPV DNA (Digene Hybrid Capture [HC II] assay) in anal specimens collected in SurePath liquid medium from 118 patients; 54.8% of cases diagnosed as atypical squamous cells of undetermined significance (ASC-US) and 87.8% diagnosed as low-grade squamous intraepithelial lesion (LSIL) or above tested positive for high- risk HPV DNA (B+).
  • Although a cytological diagnosis of ASC-US or above was a reliable indicator for AIN, cytology frequently did not accurately predict the grade of SIL in subsequent biopsy.
  • [MeSH-major] Anal Canal / virology. Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. Carcinoma, Squamous Cell / diagnosis. Papillomavirus Infections / diagnosis. Tumor Virus Infections / diagnosis

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078257.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Viral
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49. Ma H, Liu M, Zhang FM, Wang J: [Cytotoxicity of several materials of full crowns on human gingival fibroblast cells in vitro]. Shanghai Kou Qiang Yi Xue; 2008 Oct;17(5):510-4
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  • PURPOSE: To evaluate the cytotoxicity of Ni-Cr base metal alloy, gold casting alloy and castable dental ceramic on human gingival fibroblast cells (HGFC)ain vitro.

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  • (PMID = 18989594.001).
  • [ISSN] 1006-7248
  • [Journal-full-title] Shanghai kou qiang yi xue = Shanghai journal of stomatology
  • [ISO-abbreviation] Shanghai Kou Qiang Yi Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Chromium Alloys; 0 / Dental Alloys
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50. Delibasis KK, Asvestas PA, Mouravliansky NA, Economopoulos TL, Matsopoulos GK: Artificial immune network for automatic point correspondence in medical images. Conf Proc IEEE Eng Med Biol Soc; 2007;2007:840-3
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  • In this work, an automatic method for point-by point correspondence between medical images is presented based on the implementation of an Artificial Immune Network (AIN).
  • AIN is a relatively novel population based algorithm, which when applied to multimodal function optimization exhibit the attractive feature of locating, the global minimum of a function, as well as a large number of strong local optimum points.
  • In this work, AIN has been modified and applied to the problem of automatic point correspondence from pairs of images.
  • The performance of the proposed algorithm using the AIN is evaluated against a standardized method for automatic correspondence, the template matching, in terms of the accuracy of the correspondence.

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  • (PMID = 18002087.001).
  • [ISSN] 1557-170X
  • [Journal-full-title] Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
  • [ISO-abbreviation] Conf Proc IEEE Eng Med Biol Soc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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51. Hursting SD, Perkins SN, Lavigne JA, Beltran L, Haines DC, Hill HL, Alvord WG, Barrett JC, DiGiovanni J: Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice. Mol Carcinog; 2009 Aug;48(8):671-7
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  • (1) AIN-76A diet;.
  • (2) AIN-76A diet with 0.5% p-cresidine; or (3) AIN-76A diet with 0.5% p-cresidine + 0.00075% indomethacin.

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  • (PMID = 19415693.001).
  • [ISSN] 1098-2744
  • [Journal-full-title] Molecular carcinogenesis
  • [ISO-abbreviation] Mol. Carcinog.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA37111; United States / NCI NIH HHS / CO / N01-CO-12400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aniline Compounds; 0 / Keratin-5; 4C11L78UR3 / cresidine; 67763-96-6 / Insulin-Like Growth Factor I
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52. Shrestha S, Ehlers SJ, Lee JY, Fernandez ML, Koo SI: Dietary green tea extract lowers plasma and hepatic triglycerides and decreases the expression of sterol regulatory element-binding protein-1c mRNA and its responsive genes in fructose-fed, ovariectomized rats. J Nutr; 2009 Apr;139(4):640-5
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  • 1) a control group (S) fed the AIN-93G diet with corn starch as the major carbohydrate source;.

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  • (PMID = 19193814.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] ENG
  • [Grant] United States / NCCIH NIH HHS / AT / R21AT001363-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / RNA, Messenger; 0 / Sterol Regulatory Element Binding Protein 1; 0 / Tea; 0 / Triglycerides; 30237-26-4 / Fructose
  • [Other-IDs] NLM/ PMC2666357
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53. Li L, Xie Y, El-Sayed WM, Szakacs JG, Franklin MR, Roberts JC: Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse. J Biochem Mol Toxicol; 2005;19(6):396-405
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  • Seven days after initiation of an AIN-76A diet supplemented with sodium selenite (5 ppm Se), L-selenomethionine (3.75 ppm Se), Se-methyl-L-selenocysteine (3 ppm Se), L-selenocystine (15 ppm Se), SCA (15 ppm Se), OSCA (15 ppm Se), or MSCA (15 ppm Se), mice received 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; 10 micromol, i.p.).

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc. J Biochem Mol Toxicol 19:396-405, 2005
  • (PMID = 16421895.001).
  • [ISSN] 1095-6670
  • [Journal-full-title] Journal of biochemical and molecular toxicology
  • [ISO-abbreviation] J. Biochem. Mol. Toxicol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA42014; United States / NIGMS NIH HHS / GM / R01 GM58913; United States / NCRR NIH HHS / RR / RR06262; United States / NCRR NIH HHS / RR / S10 RR14768
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Nitrosamines; 0 / Prodrugs; 0CH9049VIS / Selenocysteine; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; EC 1.11.1.9 / Glutathione Peroxidase; H6241UJ22B / Selenium
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54. Al-Naeem AA: Hydrochemical processes and metal composition of Ain Umm-Sabah natural spring in Al-Hassa Oasis Eastern Province, Saudi Arabia. Pak J Biol Sci; 2008 Jan 15;11(2):244-9
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  • [Title] Hydrochemical processes and metal composition of Ain Umm-Sabah natural spring in Al-Hassa Oasis Eastern Province, Saudi Arabia.
  • A total of 10 water samples were collected from Ain Umm Sabah at different times and from different locations from the spring basin.
  • The Ain Umm Sabah water is Na-Cl dominant water and can create soil sodicity problems and cause Na and Cl ion toxicity to plants if used for irrigation of sensitive crops.

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  • (PMID = 18817197.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences : PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Metals
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55. El-Saify MY, Shaheen MA, Sabbour SM, Basal AA: Nocturnal attacks, emergency room visits and ICU admission of pediatric asthma: frequency and associated factors. J Egypt Public Health Assoc; 2008;83(5-6):353-67
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  • Records of asthmatic children in the pediatric chest clinic, Ain Shams University during 1995-2004 were reviewed.

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  • (PMID = 19493506.001).
  • [ISSN] 0013-2446
  • [Journal-full-title] The Journal of the Egyptian Public Health Association
  • [ISO-abbreviation] J Egypt Public Health Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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56. Shen G, Khor TO, Hu R, Yu S, Nair S, Ho CT, Reddy BS, Huang MT, Newmark HL, Kong AN: Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res; 2007 Oct 15;67(20):9937-44
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  • Male ApcMin/+ mice (12 per group) at age of 5 weeks were given control AIN-76A diet, diets containing 600 ppm SFN and 1.0% DBM, or a combination of 300 ppm SFN and 0.5% DBM for 10 weeks.

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  • (PMID = 17942926.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-092515; United States / NCI NIH HHS / CA / R01 CA-073674-07
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Cell Cycle Proteins; 0 / Chalcones; 0 / Isothiocyanates; 0 / Thiocyanates; 27YG812J1I / Arachidonic Acid; 4478-93-7 / sulforafan; ANS7ME8OKC / dibenzoylmethane; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
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57. Nahas SC, Nahas CS, Silva Filho EV, Levi JE, Atui FC, Marques CF: Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report. Sao Paulo Med J; 2007 Sep 6;125(5):292-4
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  • [Title] Perianal squamous cell carcinoma with high-grade anal intraepithelial neoplasia in an HIV-positive patient using highly active antiretroviral therapy: case report.
  • CONTEXT: Highly active antiretroviral therapy (HAART) has turned human immunodeficiency virus (HIV) infection into a chronic condition, and this has led to increased incidence of anal dysplasia among HIV-positive patients.
  • Routine anal evaluation including the anal canal and perianal area is recommended for this population, especially for patients infected by oncogenic human papillomavirus (HPV) types.
  • CASE REPORT: A 54-year-old homosexual HIV-positive man presented with a six-year history of recurrent perianal and anal warts.
  • He presented some condylomatous spreading lesions occupying part of the anal canal and the perianal skin, and also a well-demarcated slightly painful perianal plaque of dimensions 1.0 x 1.0 cm.
  • Both anal canal Pap smears and biopsies guided by high-resolution anoscopy revealed high-grade squamous intraepithelial lesion.
  • Biopsies of the border of the perianal plaque also revealed high-grade squamous intraepithelial lesion.
  • HPV DNA testing of the anus detected the presence of HPV-16 type.
  • Histological analysis on the excised tissue revealed high-grade squamous intraepithelial lesion with one focus of microinvasive squamous cell cancer measuring 1 mm.
  • The patient showed pathological evidence of recurrent anal and perianal high-grade squamous intraepithelial lesions at the sixth-month follow-up and required further ablation of those lesions.
  • However no invasive squamous cell carcinoma recurrence has been detected so far.
  • [MeSH-major] Antiretroviral Therapy, Highly Active / adverse effects. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. HIV Seropositivity / drug therapy. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections / pathology
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / virology. DNA, Viral / analysis. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local / diagnosis


58. Abdulle AM, Nagelkerke NJ, Abouchacra S, Pathan JY, Adem A, Obineche EN: Under- treatment and under diagnosis of hypertension: a serious problem in the United Arab Emirates. BMC Cardiovasc Disord; 2006;6:24
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  • [Title] Under- treatment and under diagnosis of hypertension: a serious problem in the United Arab Emirates.
  • This study was carried out in Al Ain, United Arab Emirates, to characterize self-reported (SR) normotensives and hypertensives in terms of actual hypertension status, demographic variables, CVD risk factors, treatment, and sequalae.
  • Hypertensives and normotensive subjects were recruited from various outpatient clinics and government organizations in Al-Ain city, United Arab Emirates (UAE) respectively.
  • RESULTS: Both under-diagnosis of hypertension (33%) and under-treatment (76%) were common.
  • Under-diagnosis of hypertension was more common among foreigners than among nationals.
  • Preventive strategies, better diagnosis and proper treatment compliance should be emphasized to reduce incidence of CVD in this population.

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  • (PMID = 16753071.001).
  • [ISSN] 1471-2261
  • [Journal-full-title] BMC cardiovascular disorders
  • [ISO-abbreviation] BMC Cardiovasc Disord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1501045
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59. Wang J, Eltoum IE, Carpenter M, Lamartiniere CA: Genistein mechanisms and timing of prostate cancer chemoprevention in lobund-wistar rats. Asian Pac J Cancer Prev; 2009 Jan-Mar;10(1):143-50
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  • Male Lobund-Wistar (L-W) rats were fed zero or 250 mg genistein/kg AIN-76A diet at designated periods of time and then injected with N-methylnitrosourea (NMU) into the dorsolateral prostate (DLP) on day 70 for cancer initiation.
  • The incidence of poorly differentiated (PD) carcinomas was 43.5% in rats fed a phytoestrogen-free AIN-76A diet only, 29.6% in rats provided genistein in the diet from postnatal days 1-35, 28.6% in rats fed genistein from months 3-11, and 20% in rats provided genistein from birth through 11 months.

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  • (PMID = 19469643.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Phytoestrogens; 684-93-5 / Methylnitrosourea; DH2M523P0H / Genistein; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 3.1.3.67 / PTEN Phosphohydrolase
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60. Power KA, Ward WE, Chen JM, Saarinen NM, Thompson LU: Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model. Bone; 2006 Jul;39(1):117-24
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  • Mice with established MCF-7 tumors were fed a basal diet (AIN-93G), divided into 5 groups, and given daily subcutaneous injections (10 mg/kg body weight) of either ENL, END, GEN, a mixture of these compounds (MIX), or vehicle as a negative control for 22 weeks.

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  • (PMID = 16469549.001).
  • [ISSN] 8756-3282
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Drug Combinations; 0 / Estrogens; 0 / Lignans; 0 / Phytoestrogens; DH2M523P0H / Genistein; OL659KIY4X / 4-Butyrolactone; X01E7E1D6H / 2,3-bis(3'-hydroxybenzyl)butyrolactone
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61. Bernard JE, Butler MO, Sandweiss L, Weidner N: Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization. Appl Immunohistochem Mol Morphol; 2008 May;16(3):215-20
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  • [Title] Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization.
  • Accurate diagnosis and grading of anal intraepithelial neoplasia (AIN) can be problematic, especially in separating AIN from anal transitional-zone epithelium.
  • To investigate if p16 would help in more accurately diagnosing and grading AIN, particularly when attempting to distinguish benign transitional-zone epithelium from high-grade AIN, we separately assessed these stains in a blinded manner on a large number of consecutive anal biopsies and anal tissues and correlated the findings with the diagnosis and grade of AIN.
  • One hundred thirty-three consecutive anal tissue specimens, from 128 patients were studied.
  • One hundred and eight were anal biopsies and 25 were hemorrhoidectomy specimens.
  • The comparisons included AIN grade (negative, 1, 2, 3) with nuclear intensity of p16 IHC (0 to 3+), AIN grade with IHC nuclear staining patterns (contiguous, patchy/rare), AIN grade with HPV-ISH [negative, low-risk (LR), high-risk (HR)] and, nuclear intensity of p16 IHC with HPV-ISH.
  • Yet, 33% of AIN negative cases were positive for nuclear p16, although with less nuclear intensity than for AIN2 or 3.
  • The kappa value for AIN/nuclear p16 intensity agreement was 0.61 (ie, substantial agreement).
  • Yet, 12.5% of AIN negative cases were positive for HPV for both LR and HR types.
  • The kappa value for AIN/HPV agreement was 0.62 (ie, substantial agreement).
  • Of interest, 30 cases were negative for AIN and p16 staining and of these, 2 (7%) were positive for HPV (both LR subtype).
  • Three cases positive for HR HPV were negative for AIN with only patchy nuclear p16 positivity.
  • We conclude that the correlation between AIN and p16 and HPV is strong enough to be quite useful in distinguishing true AIN from benign mimics, such as benign transitional-zone epithelium.

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  • (PMID = 18301250.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA Probes, HPV
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62. Ichi I, Takashima Y, Adachi N, Nakahara K, Kamikawa C, Harada-Shiba M, Kojo S: Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein B-100 in ApoE-deficient mice. Lipids; 2007 Oct;42(10):893-900
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  • ApoE-/- and wild type mice were fed a standard (AIN-76) diet or 1% cholesterol-enriched diet for 8 weeks.

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  • (PMID = 17647040.001).
  • [ISSN] 0024-4201
  • [Journal-full-title] Lipids
  • [ISO-abbreviation] Lipids
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Apolipoprotein B-100; 0 / Apolipoproteins E; 0 / Ceramides; 0 / Cholesterol, Dietary; 0 / Cholesterol, LDL; PQ6CK8PD0R / Ascorbic Acid
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63. Lin JY, Lu S, Liou YL, Liou HL: Increased IgA and IgG serum levels using a novel yam-boxthorn noodle in a BALB/c mouse model. Food Chem Toxicol; 2006 Feb;44(2):170-8
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  • The IgA and IgG serum levels in the experimental group significantly increased in a dose-dependent manner when the yam-boxthorn noodle concentration in the AIN 76 diet rose from 3% to 30%.

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  • (PMID = 16109455.001).
  • [ISSN] 0278-6915
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Immunoglobulin A; 0 / Immunoglobulin G
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64. Mattson DL, Meister CJ, Marcelle ML: Dietary protein source determines the degree of hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension; 2005 Apr;45(4):736-41
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  • Previous studies demonstrated that a whole-grain diet attenuated sodium-dependent hypertension and renal disease in Dahl salt-sensitive rats from the colony at the Medical College of Wisconsin (Dahl SS/Mcw rats) compared with rats maintained on a purified AIN-76A diet.
  • Male SS/Mcw rats were maintained on isocaloric diets identical to AIN-76A, except the source of protein (wheat gluten for casein), carbohydrate (wheat flour for sucrose), or fat (soybean oil for corn oil) was substituted in separate diets.

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  • (PMID = 15699463.001).
  • [ISSN] 1524-4563
  • [Journal-full-title] Hypertension (Dallas, Tex. : 1979)
  • [ISO-abbreviation] Hypertension
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK-62803; United States / NHLBI NIH HHS / HL / HL-29587
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caseins; 0 / Dietary Carbohydrates; 0 / Dietary Fats; 0 / Dietary Proteins; 8002-80-0 / Glutens
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65. Ardiansyah, Shirakawa H, Koseki T, Hashizume K, Komai M: The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid. Br J Nutr; 2007 Jan;97(1):67-76
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  • Male SHRSP at 4 weeks of age were divided into three groups, and for 8 weeks were fed (1) a control diet based on AIN-93M, (2) a DF of rice bran-supplemented diet at 60 g/kg and (3) an FA-supplemented diet at 0.01 g/kg.

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  • (PMID = 17217561.001).
  • [ISSN] 0007-1145
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Biomarkers; 0 / Blood Glucose; 0 / Coumaric Acids; 0 / Fungal Proteins; 0 / RNA, Messenger; 31C4KY9ESH / Nitric Oxide; 88847-89-6 / 8-oxo-7-hydrodeoxyguanosine; AVM951ZWST / ferulic acid; EC 3.2.1.- / Glycoside Hydrolases; EC 3.2.1.- / driselase; EC 3.4.15.1 / Peptidyl-Dipeptidase A; G9481N71RO / Deoxyguanosine
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66. Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V: nhl-2 Modulates microRNA activity in Caenorhabditis elegans. Cell; 2009 Mar 6;136(5):926-38
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  • NHL-2 is localized to cytoplasmic P-bodies and physically associates with the P-body protein CGH-1 and the core miRISC components ALG-1/2 and AIN-1. nhl-2 and cgh-1 mutations compromise the repression of microRNA targets in vivo but do not affect microRNA biogenesis, indicating a role for an NHL-2:CGH-1 complex in the effector phase of miRISC activity.

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  • [CommentIn] Cell. 2009 Mar 6;136(5):818-20 [19269362.001]
  • (PMID = 19269369.001).
  • [ISSN] 1097-4172
  • [Journal-full-title] Cell
  • [ISO-abbreviation] Cell
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / F32 GM069186; United States / NIGMS NIH HHS / GM / GM034028-24; United States / NIGMS NIH HHS / GM / GM30428; United States / NIGMS NIH HHS / GM / GM63826; United States / NIGMS NIH HHS / GM / F32 GM69186; United States / NIGMS NIH HHS / GM / R01 GM034028; United States / NIGMS NIH HHS / GM / R01 GM063826; United States / NIGMS NIH HHS / GM / R01 GM034028-24
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caenorhabditis elegans Proteins; 0 / Carrier Proteins; 0 / Homeodomain Proteins; 0 / MicroRNAs; 0 / NHL-2 protein, C elegans; 0 / RNA, Helminth; 0 / RNA-Induced Silencing Complex; 0 / cog-1 protein, C elegans; EC 2.7.7.- / RNA Nucleotidyltransferases; EC 2.7.7.-. / cgh-1 protein, C elegans
  • [Other-IDs] NLM/ NIHMS100684; NLM/ PMC2670343
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67. Sarwar Gilani G, Nimal Ratnayake WM, Peace RW, Mueller R: Effects of supplemental cystine or methionine on growth and lifespan of stroke-prone spontaneously hypertensive rats. Br J Nutr; 2006 Mar;95(3):443-7
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  • The data would suggest that a control diet based on cystine-supplemented casein (as recommended for normal healthy rats by the American Institute of Nutrition), may not meet the sulphur amino acid requirements for SHRSP rats, and that the methionine-supplemented casein would be an appropriate control diet for this animal model.

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  • (PMID = 16512928.001).
  • [ISSN] 0007-1145
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Caseins; 0 / Dietary Proteins; 0 / Soybean Proteins; 48TCX9A1VT / Cystine; AE28F7PNPL / Methionine
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68. Simões FC, Marques RG, Diestel CF, Caetano CE, Dinis AP, Horst NL, Nogueira Neto JF, Portela MC: Lipidic profile among rats submitted to total splenectomy isolated or combined with splenic autotransplant. Acta Cir Bras; 2007 Mar-Apr;22 Suppl 1:46-51
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  • Since the postoperative period, all animals received standard rat chow manipulated in accordance to the American Institute of Nutrition Rodents Diets (1993).

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  • (PMID = 17505655.001).
  • [ISSN] 0102-8650
  • [Journal-full-title] Acta cirurgica brasileira
  • [ISO-abbreviation] Acta Cir Bras
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Lipids; 0 / Lipoproteins; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol
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69. Kreuter A, Brockmeyer NH, Wieland U, German Competence Network HIV/AIDS: Irregularly shaped leucoplakic lesion of the anus. Diagnosis: anal intraepithelial neoplasia (AIN). Clin Exp Dermatol; 2007 Sep;32(5):621-3
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  • [Title] Irregularly shaped leucoplakic lesion of the anus. Diagnosis: anal intraepithelial neoplasia (AIN).
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Leukoplakia / pathology. Papillomavirus Infections / complications
  • [MeSH-minor] Adult. Antiretroviral Therapy, Highly Active. Diagnosis, Differential. Homosexuality, Male. Humans. Male. Papillomaviridae / isolation & purification. Precancerous Conditions / pathology. Risk Factors

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  • (PMID = 17425644.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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70. Gasztonyi B, Pár G, Pár A, Hunyady B: [Safety of pegylated interferon in patients with hepatitis C virus induced cirrhosis]. Orv Hetil; 2005 Nov 27;146(48):2431-4
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  • OBJECTIVES: The authors described their experience with the therapy with pegylated interferon and its safety in patients with hepatitis C virus (HCV) induced liver cirrhosis treated at First Department of Medicine, Medical School, University of Pécs and at Tawam Hospital, Al Ain, United Arab Emirates.

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  • (PMID = 16408382.001).
  • [ISSN] 0030-6002
  • [Journal-full-title] Orvosi hetilap
  • [ISO-abbreviation] Orv Hetil
  • [Language] hun
  • [Publication-type] Clinical Trial; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2a; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 76543-88-9 / interferon alfa-2a; 99210-65-8 / interferon alfa-2b
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71. Hirayama K, Uetsuka K, Kuwabara Y, Tamura M, Itoh K: Vitamin K deficiency of germfree mice caused by feeding standard purified diet sterilized by gamma-irradiation. Exp Anim; 2007 Jul;56(4):273-8
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  • Germfree mice died when they were fed a purified diet of AIN-76 formula sterilized by gamma-irradiation.
  • Germfree mice were fed purified diets of AIN-76 or AIN-93M formula, which were pelleted and sterilized by gamma-irradiation at a dose of 50 kGy.
  • One half of the mice fed the AIN-76 diet died within two weeks and the surviving animals were also in poor health, while 91% of mice fed the AIN-93M diet survived.
  • Histologically, degeneration with inflammatory cell infiltration was observed as well as hemorrhage and fibrosis in the heart muscles of mice fed the AIN-76 diet.
  • Prothrombin time (PT) and activated partial thromboplastin time (APTT) were extremely prolonged when mice were fed the AIN-76 diet.
  • The animals totally recovered when they were intragastrically administered 1 microg/day of vitamin K(3) from the third day of feeding of the AIN-76 diet, except for PT and APTT which were still slightly longer than in mice fed the AIN-93M diet.
  • The concentration of vitamin K(3) supplied in the AIN-76 diet decreased to an undetectable level after gamma-irradiation, while the AIN-93M diet contained 240 microg/kg of vitamin K(1).
  • These results indicate that the deaths of the germfree mice fed the gamma-irradiated AIN-76 diet were caused by vitamin K deficiency.

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  • (PMID = 17660681.001).
  • [ISSN] 1341-1357
  • [Journal-full-title] Experimental animals
  • [ISO-abbreviation] Exp. Anim.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 723JX6CXY5 / Vitamin K 3; 84-80-0 / Vitamin K 1
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72. Gormley RH, Kovarik CL: Dermatologic manifestations of HPV in HIV-infected individuals. Curr HIV/AIDS Rep; 2009 Aug;6(3):130-8
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  • Anogenital HPV-related disease includes benign condyloma acuminata, the most common cutaneous manifestation of genital HPV infection; intermediate malignancy or premalignant conditions including giant condyloma acuminata (also called Buschke-Loewenstein tumor), anal intraepithelial neoplasia, penile intraepithelial neoplasia, and vaginal or vulvar intraepithelial neoplasia; and frankly malignant disease including Bowen's disease and invasive anal, penile, or vulvar carcinoma.

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  • (PMID = 19589298.001).
  • [ISSN] 1548-3576
  • [Journal-full-title] Current HIV/AIDS reports
  • [ISO-abbreviation] Curr HIV/AIDS Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Papillomavirus Vaccines
  • [Number-of-references] 69
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73. Chin-Hong PV, Berry JM, Cheng SC, Catania JA, Da Costa M, Darragh TM, Fishman F, Jay N, Pollack LM, Palefsky JM: Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men. Ann Intern Med; 2008 Sep 2;149(5):300-6
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  • [Title] Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men.
  • BACKGROUND: Human papillomavirus (HPV)-associated anal cancer is increasing in prevalence and is more common among men who have sex with men and HIV-positive individuals than cervical cancer is among women in the United States.
  • Cytology screening can detect the anal cancer precursor, anal intraepithelial neoplasia (AIN).
  • Little is known about self-collected samples for AIN screening, and few community-based AIN estimates exist.
  • OBJECTIVE: To compare the sensitivity of self-collected versus clinician-collected anal cytology specimens to detect biopsy-confirmed AIN and the prevalence estimate of AIN in a community sample.
  • Participants were mailed anal cytology self-collection kits with instructions.
  • Clinicians repeated anal cytology and performed high-resolution anoscopy with biopsies as the diagnostic reference standard.
  • MEASUREMENTS: Prevalence of anal HPV and AIN.
  • Sensitivity and specificity of self-collected and clinician-collected anal cytology specimens to diagnose AIN were calculated.
  • RESULTS: Biopsy-proven AIN was diagnosed in 57% of HIV-positive and 35% of HIV-negative participants (P = 0.04), and 80% provided adequate self-collected specimens for interpretation.
  • The sensitivity of cytology to detect AIN in HIV-positive men was 75% (95% CI, 51% to 93%) when self-collected and 90% (CI, 68% to 99%) when clinician-collected; respective values in HIV-negative men were 48% (CI, 26% to 70%) and 62% (CI, 38% to 82%).
  • The specificity of cytology to detect AIN in HIV-positive men was 50% (CI, 22% to 78%) when self-collected and 64% (CI, 36% to 86%) when clinician-collected; respective values in HIV-negative men were 86% (CI, 71% to 94%) and 85% (CI, 72% to 93%).
  • CONCLUSION: In a community-based sample, a high proportion of HIV-positive and HIV-negative men who have sex with men have AIN.
  • The sensitivity of cytology to detect AIN is higher for clinician-collected versus self-collected specimens and for HIV-positive versus HIV-negative men.
  • The specificity of cytology to detect AIN is higher in HIV-negative versus HIV-positive men.
  • However, the probability of AIN in a patient with a negative cytology result may not be low enough (23% for HIV-negative men and 45% for HIV-positive men with a patient-collected specimen) for clinicians to be comfortable recommending no anoscopy for those with a negative cytology result if done as a one-time test.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Cytological Techniques / methods. Homosexuality. Papillomavirus Infections / pathology. Specimen Handling / methods
  • [MeSH-minor] Adult. Aged. Anal Canal / pathology. Biopsy. Endoscopy, Gastrointestinal. HIV Seronegativity. HIV Seropositivity / epidemiology. HIV Seropositivity / pathology. HIV Seropositivity / virology. Humans. Male. Middle Aged. Prevalence. San Francisco / epidemiology. Sensitivity and Specificity

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  • [CommentIn] Ann Intern Med. 2009 Feb 17;150(4):283-4; author reply 284-5 [19221387.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2008 Sep 2;149(5):I38 [18765696.001]
  • (PMID = 18765699.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NIAID NIH HHS / AI / K23 AI054157; United States / NIAID NIH HHS / AI / R01 CA/AI 88739; United States / NCI NIH HHS / CA / R01 CA54053; United States / NIMH NIH HHS / MH / R01 MH54320
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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74. Lin CY, Tsai ZY, Cheng IC, Lin SH: Effects of fermented soy milk on the liver lipids under oxidative stress. World J Gastroenterol; 2005 Dec 14;11(46):7355-8
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  • METHODS: Forty-five healthy male Sprague-Dawley rats were randomly assigned to five groups according to five different diets: control (AIN-76), AIN-76+high-dose fermented soy milk powder, AIN-76+low-dose fermented soy milk powder, AIN-76+high-dose milk yogurt powder and AIN-76+low-dose milk yogurt powder.

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  • (PMID = 16437642.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Powders; 0 / Thiobarbituric Acid Reactive Substances; CL2T97X0V0 / Carbon Tetrachloride; EC 3.1.3.1 / Alkaline Phosphatase
  • [Other-IDs] NLM/ PMC4725133
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75. Grafe MW, Kim PD, Rosenwasser MP, Strauch RJ: Wrist denervation and the anterior interosseous nerve: anatomic considerations. J Hand Surg Am; 2005 Nov;30(6):1221-5
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  • PURPOSE: Wrist denervation via resection of the distal anterior interosseous nerve (AIN) and the posterior interosseous nerve (PIN) is an effective treatment for chronic wrist pain.
  • When performing this procedure through a dorsal approach we have been impressed by anatomic variations of the AIN.
  • The purpose of this study was to elucidate the anatomy of the AIN and PIN as encountered through a dorsal distal forearm incision.
  • A dorsal approach to the distal forearm was made to identify the anatomy of the PIN and AIN.
  • The location and diameter of all AIN branches were noted by using an operating stereoscopic microscope at x 25 magnification and a precision caliper.
  • RESULTS: The anatomy of the AIN was variable.
  • The average AIN diameter proximal to the PQ was 1.5 mm.
  • The average number of AIN motor branches was 4.2.
  • CONCLUSIONS: Resection of the AIN at a point 4 cm proximal to the proximal point of the ulnar head would denervate completely the PQ in our cadaver population.
  • Division of the AIN 2 cm proximal to the ulnar head would spare most of the PQ motor branches.

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  • (PMID = 16344179.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Watanabe M, Ayugase J: Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice. J Food Sci; 2010 Nov-Dec;75(9):H294-9
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  • Mice (C57BL/KsJ-lepr(db)/lepr(db), db/db) were fed a diet containing 0%, 5%, or 10% BS based on AIN-93G for 21 d.
  • Plasma parameters, such as total cholesterol, arteriosclerotic index, thiobarbituric acid reactive substances (TBARS), and the HbA1c concentration of whole blood in the diabetic BS-fed groups were lower than those in the diabetic control (AIN-93G) group.

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  • [Copyright] © 2010 Institute of Food Technologists®
  • (PMID = 21535603.001).
  • [ISSN] 1750-3841
  • [Journal-full-title] Journal of food science
  • [ISO-abbreviation] J. Food Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anthocyanins; 0 / Bile Acids and Salts; 0 / Blood Glucose; 0 / Flavonoids; 0 / Hemoglobin A, Glycosylated; 0 / Hypoglycemic Agents; 0 / Thiobarbituric Acid Reactive Substances; 0 / Triglycerides; 97C5T2UQ7J / Cholesterol; EC 1.1.1.- / Hydroxymethylglutaryl CoA Reductases; EC 1.14.13.17 / Cholesterol 7-alpha-Hydroxylase; EC 1.14.13.17 / Cyp7a1 protein, mouse
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77. Al-Sarraj T, Saadi H, Volek JS, Fernandez ML: Metabolic syndrome prevalence, dietary intake, and cardiovascular risk profile among overweight and obese adults 18-50 years old from the United Arab Emirates. Metab Syndr Relat Disord; 2010 Feb;8(1):39-46
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  • METHODS: We recruited 227 overweight/obese Emirati adults living in the city of Al-Ain, Emirati of Abu Dhabi to screen for the metabolic syndrome and to assess for the most relevant criteria for the metabolic syndrome in this population.
  • [MeSH-major] Metabolic Syndrome X / diagnosis. Obesity / diagnosis

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  • (PMID = 19929603.001).
  • [ISSN] 1557-8518
  • [Journal-full-title] Metabolic syndrome and related disorders
  • [ISO-abbreviation] Metab Syndr Relat Disord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cholesterol, HDL; 0 / Cholesterol, LDL
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78. Appel GB: The treatment of acute interstitial nephritis: More data at last. Kidney Int; 2008 Apr;73(8):905-7
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  • Acute interstitial nephritis (AIN) is an uncommon form of acute renal failure that is usually medication related.
  • The study by González et al., although it has limitations, provides solid support for the early use of corticosteroids in the treatment of drug-related AIN.

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  • [CommentOn] Kidney Int. 2008 Apr;73(8):940-6 [18185501.001]
  • (PMID = 18379525.001).
  • [ISSN] 1523-1755
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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79. Byun JS, Lee SS: Effect of soybeans and sword beans on bone metabolism in a rat model of osteoporosis. Ann Nutr Metab; 2010;56(2):106-12
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  • METHODS: Seven-week-old female Sprague-Dawley rats were raised for 2 weeks on a calcium-free diet based on the American Institute of Nutrition (AIN)-93M diets.

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20110670.001).
  • [ISSN] 1421-9697
  • [Journal-full-title] Annals of nutrition & metabolism
  • [ISO-abbreviation] Ann. Nutr. Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Biomarkers; 0 / Tumor Necrosis Factor-alpha; 104982-03-8 / Osteocalcin; 90032-33-0 / deoxypyridinoline
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80. Bissar-Tadmouri N, Tadmouri GO: Bibliometric analyses of biomedical research outputs in Lebanon and the United Arab Emirates (1988-2007). Saudi Med J; 2009 Jan;30(1):130-9
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  • In Lebanon, most of the citations originated from the capital city of Beirut, mainly the American University of Beirut.
  • In the UAE, most of the biomedical publications originate from Al-Ain University.
  • In the UAE, the plateau phase for biomedical research output size could be due to the limitation of most of the research in the country to Al-Ain University.

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  • (PMID = 19139787.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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81. Cörekçi S, Usanmaz D, Tekeli Z, Cakmak M, Ozçelik S, Ozbay E: Surface morphology of Al0.3Ga0.7N/Al2O3-high electron mobility transistor structure. J Nanosci Nanotechnol; 2008 Feb;8(2):640-4
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  • We present surface properties of buffer films (AIN and GaN) and Al0.3Gao.zN/Al2O3-High Electron Mobility Transistor (HEMT) structures with/without AIN interlayer grown on High Temperature (HT)-AIN buffer/Al2O3 substrate and Al2O3 substrate.
  • HT-AIN buffer layer can have a significant impact on the surface morphology of Al0.3Ga0.7N/Al2O3-HEMT structures.

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  • (PMID = 18464384.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Campbell JK, Stroud CK, Nakamura MT, Lila MA, Erdman JW Jr: Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. J Nutr; 2006 Nov;136(11):2813-9
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  • To evaluate interrelations between phytofluene, lycopene, or tomato powder consumption and androgen status, 8-wk-old male F344 rats (fed a control AIN 93G diet) were castrated or sham-operated and subsequently provided with daily oral supplementation of phytofluene or lycopene ( approximately 0.7 mg/d) or fed a 10% tomato powder supplemented diet (AIN 93G) for 4 d.

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  • (PMID = 17056806.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 112649-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FABP3 protein, rat; 0 / Fatty Acid-Binding Proteins; 0 / PPAR gamma; 0 / RNA, Messenger; 08J2K08A3Y / Dihydrotestosterone; 36-88-4 / Carotenoids; 3XMK78S47O / Testosterone; 6NUO4W7YQ6 / phytofluene; EC 1.1.- / 17-Hydroxysteroid Dehydrogenases; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / Cyp3a1 protein, rat; EC 1.14.14.1 / Cytochrome P-450 CYP2B1; EC 1.14.14.1 / Cytochrome P-450 CYP3A; SB0N2N0WV6 / lycopene
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83. Kinser S, Li M, Jia Q, Pestka JJ: Truncated deoxynivalenol-induced splenic immediate early gene response in mice consuming (n-3) polyunsaturated fatty acids. J Nutr Biochem; 2005 Feb;16(2):88-95
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  • Mice were fed AIN-93G diet containing 1% corn oil (CO) plus 6% oleic acid (control) or a diet containing 1% CO, 2% fish oil enriched in the (n-3)-PUFAs docosahexaenoic and eicosapentaenoic acid and 4% oleic acid.


84. Zhang J, Martins CR, Fansler ZB, Roemer KL, Kincaid EA, Gustafson KS, Heitjan DF, Clark DP: DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma. Clin Cancer Res; 2005 Sep 15;11(18):6544-9
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  • [Title] DNA methylation in anal intraepithelial lesions and anal squamous cell carcinoma.
  • PURPOSE: Anal intraepithelial neoplasia is associated with human papillomavirus infection and may progress to invasive squamous cell carcinoma (SCC), which is increasing in immunocompromised patients.
  • We hypothesize that anal intraepithelial neoplasia is associated with abnormal DNA methylation and that detection of these events may be used to improve screening programs.
  • EXPERIMENTAL DESIGN: Seventy-six patients were identified who underwent anal cytology screening and subsequent biopsy at our institution between 1999 and 2004.
  • The specimens from these patients included 184 anal biopsies [normal, n = 57; low-grade squamous intraepithelial lesion (LSIL), n = 74; high-grade squamous intraepithelial lesion (HSIL), n = 41; and invasive SCC, n = 12] and 37 residual liquid-based anal cytology specimens (normal, n = 11; LSIL, n = 12; HSIL, n = 14).
  • CONCLUSIONS: Aberrant DNA methylation is a frequent event in anal HSIL and SCC.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. DNA Methylation

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  • (PMID = 16166431.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Adenomatous Polyposis Coli Protein; 0 / CADM1 protein, human; 0 / Carrier Proteins; 0 / Cell Adhesion Molecules; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / HIC1 protein, human; 0 / Immunoglobulins; 0 / Kruppel-Like Transcription Factors; 0 / MLH1 protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / RASSF1 protein, human; 0 / Receptors, Retinoic Acid; 0 / Transcription Factors; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Proteins; 0 / retinoic acid receptor beta; EC 2.1.1.63 / O(6)-Methylguanine-DNA Methyltransferase; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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85. Himmel HJ: Possible pathways of CVD processes leading to III-V semiconductors via a two-dimensional growth. Chemphyschem; 2005 Apr;6(4):706-13
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  • Because some of the systems calculated herein contain a substantial number of atoms (up to 144), it is limited to intermediates on the way to solid AIN.
  • The structures are compared with that of solid AIN in its most stable Wurzit-type structure.

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  • (PMID = 15881587.001).
  • [ISSN] 1439-4235
  • [Journal-full-title] Chemphyschem : a European journal of chemical physics and physical chemistry
  • [ISO-abbreviation] Chemphyschem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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86. Elalfy MS, Abdin IA, El Safy UR, Ibrahim AS, Ebeid FS, Salem DS: Cardiac events and cardiac T2* in Egyptian children and young adults with beta-thalassemia major taking deferoxamine. Hematol Oncol Stem Cell Ther; 2010;3(4):174-8
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  • DESIGN AND SETTING: Prospective, observational, 10-year follow-up of patients attending Ain Shams Thalassemia Unit, Cairo, Egypt.

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  • (PMID = 21150236.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Benzoates; 0 / Pyridones; 0 / Siderophores; 0 / Triazoles; 2BTY8KH53L / deferiprone; 9007-73-2 / Ferritins; J06Y7MXW4D / Deferoxamine; V8G4MOF2V9 / deferasirox
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87. Abdel Rahman AT, Hafez SF, Abdelhakam SM, Ali-Eldin ZA, Esmat IM, Elsayed MS, Aboul-Fotouh A: Antimicrobial resistant bacteria among health care workers in intensive care units at Ain Shams University Hospitals. J Egypt Soc Parasitol; 2010 Apr;40(1):71-83
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  • [Title] Antimicrobial resistant bacteria among health care workers in intensive care units at Ain Shams University Hospitals.

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  • (PMID = 20503587.001).
  • [ISSN] 1110-0583
  • [Journal-full-title] Journal of the Egyptian Society of Parasitology
  • [ISO-abbreviation] J Egypt Soc Parasitol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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88. Scott H, Khoury J, Moore BA, Weissman S: Routine anal cytology screening for anal squamous intraepithelial lesions in an urban HIV clinic. Sex Transm Dis; 2008 Feb;35(2):197-202
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Routine anal cytology screening for anal squamous intraepithelial lesions in an urban HIV clinic.
  • OBJECTIVES: The purpose of this study is to describe our experience with routine anal cancer screening using anal cytology, determine risk factors for abnormal anal cytology, and determine if an association exists between cytology and histology in patients with HIV infection.
  • RESULTS: Overall, 276 of 560 of the clinic patients received a screening anal cytology during the study period.
  • Of these patients, 11 were excluded from the analysis and 74 of 265 (27.9%) patients screened had an abnormal anal cytology.
  • Forty-nine percent were African American, 34% Caucasian, and 17% Hispanic.
  • They were also more likely to have a lower CD4+ nadir (142 cells/mm3 vs. 223 cells/mm3, P = 0.005) and CD4+ at time of anal cytology (353 cells/mm3 vs. 497 cells/mm3, P <0.001).
  • Those with an abnormal anal cytology also had higher occurrence of anal disease on perianal visual inspection (30% vs. 9%, P <0.001) and were more likely to have a history of genital warts (23% vs. 12%, P = 0.02) or herpes (35% vs. 22%, P = 0.02).
  • Two patients had anal intraepithelial neoplasia (AIN) I, 2 AIN II, 3 AIN III, and 2 squamous cell carcinoma in situ on histology.
  • CONCLUSION: Routine anal cytology screening is a feasible tool to incorporate into HIV care for patients regardless of gender and HIV risk factors.
  • [MeSH-major] Anus Neoplasms / diagnosis. HIV Infections / complications. Neoplasms, Squamous Cell / pathology. Urban Health Services / organization & administration
  • [MeSH-minor] Adult. Aged. Anal Canal / pathology. Colonoscopy / methods. Female. Follow-Up Studies. Humans. Logistic Models. Male. Middle Aged. Multivariate Analysis


89. Al-Muhairi SS, Zoubeidi TA, Ellis ME, Safa WF, Joseph J: Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates. Saudi Med J; 2006 Jul;27(7):1044-8
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  • [Title] Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates.
  • METHODS: We retrospectively analyze the data collected from all inpatients over the age of 16 years with a diagnosis of pneumonia in Tawam Hospital, Al-Ain, United Arab Emirates between the years 1997 and 2002.
  • [MeSH-major] Pneumonia / diagnosis

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  • (PMID = 16830028.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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90. Caers J, Peeters P, Vanden Houte K, Sennesael J, Van der Niepen P, Verbeelen D: Acute interstitial nephritis associated with salmonellosis. Eur J Intern Med; 2006 May;17(3):217-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Acute interstitial nephritis (AIN) is a common cause of acute renal failure.
  • We report a case of AIN, confirmed by renal biopsy, that developed in a patient with typhoid fever due to a Salmonella hadar infection.
  • AIN secondary to Salmonella infection is a rare complication that has only been described twice in the literature.
  • Salmonella should be added to the list of possible causes of AIN.

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  • (PMID = 16618461.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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91. Palefsky J: Editorial comment: screening and treatment of AIN to prevent anal cancer--where do we stand? AIDS Read; 2005 Feb;15(2):87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Editorial comment: screening and treatment of AIN to prevent anal cancer--where do we stand?
  • [MeSH-major] Anus Neoplasms / prevention & control. Carcinoma in Situ / prevention & control. Cervical Intraepithelial Neoplasia / prevention & control. Papillomavirus Infections / pathology. Precancerous Conditions / pathology. Uterine Cervical Neoplasms / prevention & control


92. Yang K, Lamprecht SA, Shinozaki H, Fan K, Yang W, Newmark HL, Kopelovich L, Edelmann W, Jin B, Gravaghi C, Augenlicht L, Kucherlapati R, Lipkin M: Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. J Nutr; 2008 Sep;138(9):1658-63
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  • We have demonstrated that a Western-style diet (WD) with low levels of calcium and cholecalciferol and high levels of (n-6) PUFA, increased the incidence of neoplasia in mouse intestine compared with a standard AIN-76A diet; models included wild-type mice and mice with targeted mutations.
  • In the present study, adenomatous polyposis coli (Apc)(1638N/+) mice carrying a heterozygous Apc mutation were fed either an AIN-76A diet, a WD, or a WD supplemented with calcium and cholecalciferol (WD/Ca/VitD3).
  • Feeding WD to Apc(1638N/+) mice not only enhanced cyclin D1 expression in colonic epithelium compared with AIN-76A treatment as previously reported but also significantly increased the expression of the antiapoptotic protein B-cell lymphoma 2 (Bcl-2) concomitantly with a decrease in the proapoptotic Bcl2-associated X protein and the number of apoptotic epithelial cells.
  • Importantly, Apc(1638N/+) mice fed the WD/Ca/VitD3 diet did not develop colonic tumors, further indicating that dietary calcium and cholecalciferol have a key role in the chemoprevention of colorectal neoplasia in this mouse model of human colon cancer.

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  • (PMID = 18716166.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA84301; United States / NIEHS NIH HHS / ES / ES-11040; United States / NCI NIH HHS / CN / N01-CN-43302; United States / NCI NIH HHS / CN / N01-CN-43308; United States / NCI NIH HHS / CA / U54-CA100926
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Calcium, Dietary; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / bcl-2-Associated X Protein; 136601-57-5 / Cyclin D1; 1C6V77QF41 / Cholecalciferol
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93. Ramos MI, Siqueira EM, Isomura CC, Barbosa AM, Arruda SF: Bocaiuva (Acrocomia aculeata (Jacq.) Lodd) improved Vitamin A status in rats. J Agric Food Chem; 2007 Apr 18;55(8):3186-90
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  • After the depletion period, the vitamin A deficient rats were separated into two groups and fed an AIN-93G modified diet, which contained 14 400 microg of pure beta-carotene (beta-carotene diet) or 13 475 microg of beta-carotene from 275 g of bocaiuva pulp (bocaiuva diet) per 1 kg of the diet as a vitamin A source.

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  • (PMID = 17373815.001).
  • [ISSN] 0021-8561
  • [Journal-full-title] Journal of agricultural and food chemistry
  • [ISO-abbreviation] J. Agric. Food Chem.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 01YAE03M7J / beta Carotene
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94. Fox PA: Human papillomavirus and anal intraepithelial neoplasia. Curr Opin Infect Dis; 2006 Feb;19(1):62-6
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  • [Title] Human papillomavirus and anal intraepithelial neoplasia.
  • PURPOSE OF REVIEW: A review of recent developments in the understanding of the natural history of anal squamous carcinoma arising from areas of high-grade anal intraepithelial neoplasia.
  • RECENT FINDINGS: Anal intraepithelial neoplasia is a consequence of chronic human papillomavirus infection in the anal canal and appears to be driven by high viral loads of human papillomavirus.
  • Anal intraepithelial neoplasia is equally prevalent in different age groups of men who have sex with men, but in other respects what is known of its natural history resembles that of cervical intraepithelial neoplasia.
  • HIV-positives who practise receptive anal intercourse are at highest risk of anal intraepithelial neoplasia.
  • Screening is easy to perform using cytology; the limitations of anal cytology being similar to those of cervical cytology.
  • [MeSH-major] Anus Neoplasms. Carcinoma in Situ. Carcinoma, Squamous Cell. Papillomaviridae / pathogenicity. Papillomavirus Infections

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  • (PMID = 16374220.001).
  • [ISSN] 0951-7375
  • [Journal-full-title] Current opinion in infectious diseases
  • [ISO-abbreviation] Curr. Opin. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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95. Capsoni F, Sarzi-Puttini P, Zanella A: Primary and secondary autoimmune neutropenia. Arthritis Res Ther; 2005;7(5):208-14
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  • In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious infections and exhibits a self-limited course.
  • Secondary AIN is more commonly seen in adults and underlying causes include collagen disorders, drugs, viruses and lymphoproliferative disorders.
  • In most patients with AIN, antibodies recognize antigens located on the IgG Fc receptor type 3b but other target antigens have been recently identified in secondary AIN.
  • Granulocyte colony-stimulating factor is a proven treatment in patients with AIN of all types and is now preferred to other possible therapies.

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  • (PMID = 16207350.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Antigens, CD; 0 / Autoantigens; 0 / FCGR3B protein, human; 0 / GPI-Linked Proteins; 0 / Immunoglobulins, Intravenous; 0 / Isoantigens; 0 / Receptors, IgG; 0 / neutrophil-specific antigen NA1, human; 143011-72-7 / Granulocyte Colony-Stimulating Factor
  • [Number-of-references] 67
  • [Other-IDs] NLM/ PMC1257445
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96. Moselhy SS, Demerdash SH: Serum free L-carnitine in association with myoglobin as a diagnostic marker of acute myocardial infarction. Clin Biochem; 2009 Jan;42(1-2):78-82
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  • BACKGROUND: Early diagnosis of acute myocardial infarction (AMI) in patients with chest pain is necessary to initiate appropriate treatment.
  • Elevation of ST-segment in ECG is the only marker that cardiologists depend on in diagnosis.
  • DESIGN AND METHODS: In the present study serum total CK activity and CK-MB, Myo, and free L-carnitine levels were determined in 90 patients admitted to the ICU at Ain Shams University Hospital and correlated the sensitivity and specificity of each parameter.
  • For this reason, serum free L-carnitine can be used as a good predictor for AMI diagnosis from other diseases.
  • [MeSH-major] Carnitine / blood. Myocardial Infarction / blood. Myocardial Infarction / diagnosis. Myoglobin / blood


97. Dlugos CA: Analyses of smooth endoplasmic reticulum of cerebellar parallel fibers in aging, ethanol-fed rats. Alcohol; 2005 Jan;35(1):67-73
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  • Male Fischer 344 rats (n = 120; age = 12 months old) were randomly divided into three dietary groups (40 rats per group) and fed rat chow, the AIN-93M liquid control diet, or the AIN-93M liquid ethanol diet (without water) for 5, 10, 20, or 40 weeks (30 rats per time point).

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  • (PMID = 15922139.001).
  • [ISSN] 0741-8329
  • [Journal-full-title] Alcohol (Fayetteville, N.Y.)
  • [ISO-abbreviation] Alcohol
  • [Language] eng
  • [Grant] United States / NIAAA NIH HHS / AA / AA13104
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol
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98. Bener A, Saad AG, Micallef R, Ghuloum S, Sabri S: Sociodemographic and clinical characteristics of patients with dissociative disorders in an Arabian society. Med Princ Pract; 2006;15(5):362-7
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  • These patients were recruited from Al-Ain and Tawam Teaching Hospitals and Al-Jahili Primary Health Care Centers in Al-Ain, United Arab Emirates.

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  • (PMID = 16888394.001).
  • [ISSN] 1011-7571
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Switzerland
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99. Moran MG, Barkley TW Jr, Hughes CB: Screening and management of anal dysplasia and anal cancer in HIV-infected patients: a guide for practice. J Assoc Nurses AIDS Care; 2010 Sep-Oct;21(5):408-16
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  • [Title] Screening and management of anal dysplasia and anal cancer in HIV-infected patients: a guide for practice.
  • People living with HIV infection have a significantly higher rate of anal cancer as compared with that of uninfected people.
  • It is believed that high-grade anal dysplasia secondary to human papillomavirus infection is a precursor to anal cancer.
  • Considering this, screening and treatment of high-grade anal dysplasia is a possible means of preventing the development of anal cancer.
  • No national or international guidelines exist to guide practice for screening and management of anal dysplasia.
  • On the basis of a review of research and expert recommendations, a guide to practice for screening and management of anal dysplasia and anal cancer is made for clinicians.
  • [MeSH-major] Anus Neoplasms / complications. HIV Infections / complications

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  • [Copyright] (c) 2010 Association of Nurses in AIDS Care. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20409734.001).
  • [ISSN] 1552-6917
  • [Journal-full-title] The Journal of the Association of Nurses in AIDS Care : JANAC
  • [ISO-abbreviation] J Assoc Nurses AIDS Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Bommareddy A, Zhang X, Schrader D, Kaushik RS, Zeman D, Matthees DP, Dwivedi C: Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. Nutr Cancer; 2009;61(2):276-83
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  • Apc(Min) mice were divided into five different groups, fed with control (AIN-93M meal), corn meal, flaxseed meal, corn oil, and flaxseed oil supplemented diets.

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  • (PMID = 19235044.001).
  • [ISSN] 1532-7914
  • [Journal-full-title] Nutrition and cancer
  • [ISO-abbreviation] Nutr Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticarcinogenic Agents; 0 / Fatty Acids; 0 / Fatty Acids, Omega-3; 0 / Lignans; 0RBV727H71 / alpha-Linolenic Acid; 8001-26-1 / Linseed Oil; 8001-30-7 / Corn Oil; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; MO0N1J0SEN / Azoxymethane
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