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1. Salama MM, Ghorab EM, Al-Abyad AG, Al-Bahy KM: Concomitant weekly vincristine and radiation followed by adjuvant vincristine and carboplatin in the treatment of high risk medulloblastoma: Ain Shams University Hospital and Sohag Cancer Center study. J Egypt Natl Canc Inst; 2006 Jun;18(2):167-74
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  • [Title] Concomitant weekly vincristine and radiation followed by adjuvant vincristine and carboplatin in the treatment of high risk medulloblastoma: Ain Shams University Hospital and Sohag Cancer Center study.
  • RESULTS: The study included seventeen high risk medulloblastoma patients presented to Ain Shams University hospitals and Sohag Cancer Center between November 2001 and March 2005.

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  • (PMID = 17496943.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5J49Q6B70F / Vincristine; BG3F62OND5 / Carboplatin
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2. Ding L, Spencer A, Morita K, Han M: The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell; 2005 Aug 19;19(4):437-47
SciCrunch. WormBase: Data: Gene Expression .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans.
  • We have identified the C. elegans ain-1 gene through a genetic suppressor screen and shown that it functions with the heterochronic genetic pathway that regulates developmental timing.
  • Biochemical analysis indicates that AIN-1 interacts with protein complexes containing an Argonaute protein, Dicer, and miRNAs.
  • AIN-1 shares homology with the candidate human neurological disease protein GW182, shown to localize in cytoplasmic processing bodies that are sites of mRNA degradation and storage.
  • A functional AIN-1::GFP also localizes at the likely worm processing bodies.
  • When coexpressed from transgenes, AIN-1 targets ALG-1 to the foci.
  • These results suggest a model where AIN-1 regulates a subset of miRISCs by localization to the processing bodies, facilitating degradation or translational inhibition of mRNA targets.

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  • (PMID = 16109369.001).
  • [ISSN] 1097-2765
  • [Journal-full-title] Molecular cell
  • [ISO-abbreviation] Mol. Cell
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ AAK32947
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM047869
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AIN-1 protein, C elegans; 0 / ALG-1 protein, C elegans; 0 / Caenorhabditis elegans Proteins; 0 / Carrier Proteins; 0 / MicroRNAs; 0 / RNA-Binding Proteins; EC 3.1.- / Endoribonucleases; EC 3.1.26.- / dcr-1 protein, C elegans; EC 3.1.26.3 / Ribonuclease III
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3. Poggel DA, Treutwein B, Calmanti C, Strasburger H: Increasing the temporal g(r)ain: double-pulse resolution is affected by the size of the attention focus. Vision Res; 2006 Sep;46(18):2998-3008
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  • [Title] Increasing the temporal g(r)ain: double-pulse resolution is affected by the size of the attention focus.

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  • (PMID = 16677680.001).
  • [ISSN] 0042-6989
  • [Journal-full-title] Vision research
  • [ISO-abbreviation] Vision Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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4. Baynouna LM, Shamsan AI, Ali TA, Al Mukini LA, Al Kuwiti MH, Al Ameri TA, Nagelkerke NJ, Abusamak AM, Ahmed NM, Al Deen SM, Jaber TM, Elkhalid AM, Revel AD, Al Husaini AI, Nour FA, Ahmad HO, Nazirudeen MK, Al Dhahiri R, Al Abdeen YO, Omar AO: A successful chronic care program in Al Ain-United Arab Emirates. BMC Health Serv Res; 2010;10:47
MedlinePlus Health Information. consumer health - Coping with Chronic Illness.

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  • [Title] A successful chronic care program in Al Ain-United Arab Emirates.

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  • (PMID = 20175917.001).
  • [ISSN] 1472-6963
  • [Journal-full-title] BMC health services research
  • [ISO-abbreviation] BMC Health Serv Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2841164
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5. Lima CP, Davis SR, Mackey AD, Scheer JB, Williamson J, Gregory JF 3rd: Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. J Nutr; 2006 Aug;136(8):2141-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets.
  • Growing rats were fed AIN-93G- or AIN-76A-based diets that ranged from adequate to deficient in vitamin B-6 (2, 1, 0.5, 0.1, or 0 mg of PN/kg diet, n = 5).
  • This design allowed assessment of the effects of supplemental methionine (AIN-76A) vs. cysteine (AIN-93G) in common research diets over a range of vitamin B-6 levels.
  • Hepatic cystathionine increased from 20 to 30 nmol/g for the 1-2 mg PN/kg diets to approximately 85 nmol/g for the 0 mg PN/kg diet; however, cysteine was reduced only in B-6-deficient rats consuming the AIN-93G diet (means of 30-40 nmol/g for adequate to 11.6 nmol/g for 0 mg PN/kg AIN-76A diet).

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  • (PMID = 16857832.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK072398; United States / NIDDK NIH HHS / DK / DK37481; United States / NIDDK NIH HHS / DK / DK56274; United States / NIDDK NIH HHS / DK / T32 DK07667
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] AE28F7PNPL / Methionine; EC 4.2.1.22 / Cystathionine beta-Synthase; EC 4.4.1.1 / Cystathionine gamma-Lyase; GAN16C9B8O / Glutathione; K848JZ4886 / Cysteine; KV2JZ1BI6Z / Pyridoxine
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6. Bouzidi A, Souahi F, Hanini S: Sorption behavior of cesium on Ain Oussera soil under different physicochemical conditions. J Hazard Mater; 2010 Dec 15;184(1-3):640-6
Hazardous Substances Data Bank. CESIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sorption behavior of cesium on Ain Oussera soil under different physicochemical conditions.
  • In the present study, the sorption behavior of cesium was investigated in Ain Oussera soil around the Es-Salam reactor facility.

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20869168.001).
  • [ISSN] 1873-3336
  • [Journal-full-title] Journal of hazardous materials
  • [ISO-abbreviation] J. Hazard. Mater.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Soil Pollutants; 1KSV9V4Y4I / Cesium
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7. Abdel Rahman AT, Hafez SF, Abdelhakam SM, Ali-Eldin ZA, Esmat IM, Elsayed MS, Aboul-Fotouh A: Antimicrobial resistant bacteria among health care workers in intensive care units at Ain Shams University Hospitals. J Egypt Soc Parasitol; 2010 Apr;40(1):71-83
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  • [Title] Antimicrobial resistant bacteria among health care workers in intensive care units at Ain Shams University Hospitals.

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  • (PMID = 20503587.001).
  • [ISSN] 1110-0583
  • [Journal-full-title] Journal of the Egyptian Society of Parasitology
  • [ISO-abbreviation] J Egypt Soc Parasitol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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8. Bouzenoune F, Boudersa F, Bensaad A, Harkat F, Siad N: [Urinary tract infections in Ain M'lila (Algeria). Antibiotic resistance of 239 strains isolated between 2006 and 2007]. Med Mal Infect; 2009 Feb;39(2):142-3
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  • [Title] [Urinary tract infections in Ain M'lila (Algeria). Antibiotic resistance of 239 strains isolated between 2006 and 2007].
  • [Transliterated title] Les infections urinaires à Ain M'lila (Algérie). Résistance aux antibiotiques des 239 souches isolées entre 2006 et 2007.

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  • (PMID = 19118964.001).
  • [ISSN] 0399-077X
  • [Journal-full-title] Médecine et maladies infectieuses
  • [ISO-abbreviation] Med Mal Infect
  • [Language] fre
  • [Publication-type] Letter
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
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9. Kreuter A, Brockmeyer NH, Wieland U, German Competence Network HIV/AIDS: Irregularly shaped leucoplakic lesion of the anus. Diagnosis: anal intraepithelial neoplasia (AIN). Clin Exp Dermatol; 2007 Sep;32(5):621-3
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  • [Title] Irregularly shaped leucoplakic lesion of the anus. Diagnosis: anal intraepithelial neoplasia (AIN).
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Leukoplakia / pathology. Papillomavirus Infections / complications
  • [MeSH-minor] Adult. Antiretroviral Therapy, Highly Active. Diagnosis, Differential. Homosexuality, Male. Humans. Male. Papillomaviridae / isolation & purification. Precancerous Conditions / pathology. Risk Factors

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  • (PMID = 17425644.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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10. Garey L, Eapen V, Adem A: International neuroscience conference on research strategies and clinical challenges in neuroscience, Al Ain, UnitedArab Emirates, November 2005. Exp Brain Res; 2006 Aug;173(2):195
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  • [Title] International neuroscience conference on research strategies and clinical challenges in neuroscience, Al Ain, UnitedArab Emirates, November 2005.

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  • (PMID = 16847615.001).
  • [ISSN] 0014-4819
  • [Journal-full-title] Experimental brain research
  • [ISO-abbreviation] Exp Brain Res
  • [Language] eng
  • [Publication-type] Congresses
  • [Publication-country] Germany
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11. Immunoregulation in Chronic Inflammatory Disorders. Proceedings of the Third Al-Ain International Immunology Meeting. Al-Ain, United Arab Emirates. March 17-20, 2008. Clin Immunol; 2009 Jan;130(1):1-109

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunoregulation in Chronic Inflammatory Disorders. Proceedings of the Third Al-Ain International Immunology Meeting. Al-Ain, United Arab Emirates. March 17-20, 2008.

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  • (PMID = 19143039.001).
  • [ISSN] 1521-7035
  • [Journal-full-title] Clinical immunology (Orlando, Fla.)
  • [ISO-abbreviation] Clin. Immunol.
  • [Language] eng
  • [Publication-type] Congresses; Overall
  • [Publication-country] United States
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12. Dash N, Ameen AS, Sheek-Hussein MM, Smego RA Jr: Epidemiology of meningitis in Al-Ain, United Arab Emirates, 2000-2005. Int J Infect Dis; 2007 Jul;11(4):309-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology of meningitis in Al-Ain, United Arab Emirates, 2000-2005.
  • OBJECTIVE: To describe the epidemiologic features of meningitis in Al-Ain Medical District, United Arab Emirates from January 2000 through June 2005.
  • METHODS: A retrospective review of clinical records and notification forms for cases of meningitis reported to the Department of Preventive Medicine, Al-Ain.
  • The incidence rate of meningitis in Al-Ain ranged between 2.2/100,000 population in 2000 and 1/100,000 in 2005, with an overall downward trend by year.

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  • (PMID = 16950640.001).
  • [ISSN] 1201-9712
  • [Journal-full-title] International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • [ISO-abbreviation] Int. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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13. Goyal RK, Tiwari AN, Mulik UP, Negi YS: Thermal, mechanical, and dielectric properties of high performance PEEK/AIN nanocomposites. J Nanosci Nanotechnol; 2009 Dec;9(12):6902-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thermal, mechanical, and dielectric properties of high performance PEEK/AIN nanocomposites.
  • The mechanical, thermal, and dielectric properties of novel high performance poly(ether-ether-ketone) (PEEK)/AIN nanocomposites were discussed.
  • The thermal stability and dielectric constant of the nanocomposites were increased slightly with AIN content.
  • The significant improvement in the properties of the nanocomposites was attributed to the good adhesion between the AIN nanoparticles and the polymer matrix.

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  • (PMID = 19908696.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Wahl RU, Blazek C, Megahed M: [HPV type 16-associated anal intraepithelial neoplasia (AIN)]. Hautarzt; 2009 May;60(5):371-2
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  • [Title] [HPV type 16-associated anal intraepithelial neoplasia (AIN)].
  • [Transliterated title] HPV-Typ-16-assoziierte anale intraepitheliale Neoplasie (AIN).
  • A 25-year-old woman had suffered from a perianal ulcer for approximately 1 year.
  • Employing virologic and histologic techniques, we confirmed the diagnosis of an intraepithelial neoplasia.
  • Anal intraepithelial neoplasia (AIN) is induced by carcinogenic human papillomaviruses.
  • Because of its frequency, AIN is a crucial differential diagnosis for lesions of the anogenital area region failing to respond to standard therapies.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / surgery. Carcinoma in Situ / diagnosis. Carcinoma in Situ / surgery. Human papillomavirus 16 / isolation & purification. Papillomavirus Infections / diagnosis. Papillomavirus Infections / surgery. Skin Neoplasms / diagnosis. Skin Neoplasms / surgery

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  • (PMID = 19430747.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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15. Palefsky J: Editorial comment: screening and treatment of AIN to prevent anal cancer--where do we stand? AIDS Read; 2005 Feb;15(2):87
International Agency for Research on Cancer - Screening Group. diagnostics - Planning and Implementing Cervical Cancer Prevention and Control Programs: A Manual for Managers .

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  • [Title] Editorial comment: screening and treatment of AIN to prevent anal cancer--where do we stand?
  • [MeSH-major] Anus Neoplasms / prevention & control. Carcinoma in Situ / prevention & control. Cervical Intraepithelial Neoplasia / prevention & control. Papillomavirus Infections / pathology. Precancerous Conditions / pathology. Uterine Cervical Neoplasms / prevention & control


16. Hamed F: Positive and Negative Temperature Dependence in the Resistivity of Crystallized Zr-Fe-Ni Metallic Glasses. Materials (Basel); 2010 Dec 07;3(12):5212-5219

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  • [Title] Positive and Negative Temperature Dependence in the Resistivity of Crystallized Zr-Fe-Ni Metallic Glasses.
  • Ni<sub>0.25</sub>Fe<sub>0.75</sub>Zr₃ metallic glassy ribbons were annealed in evacuated quartz ampoules beyond the crystallization temperatures (T<sub>x</sub> ~655 K) over the range 773 to 1,173 K for varying periods of time.
  • The resistivity of samples annealed over the temperature range 923 to 1,073 K for periods less than four hours increased as a function of decreasing temperature, while it decreased for samples annealed for more than four hours or at temperatures below 923 K or above 1,073 K for any period of time.
  • All the annealed samples were found to contain only Ni, Fe and Zr from energy dispersive X-ray (EDX) analyses.

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  • (PMID = 28883377.001).
  • [ISSN] 1996-1944
  • [Journal-full-title] Materials (Basel, Switzerland)
  • [ISO-abbreviation] Materials (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; amorphous alloys / electrical resistivity / metallic glasses / nano-crystallization / recrystallization
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17. Nasser S, Mabrouk A, Wafa AM: Twelve years epidemiological study of paediatric burns in Ain Shams University, Burn Unit, Cairo, Egypt. Burns; 2009 Dec;35(8):e8-11
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  • [Title] Twelve years epidemiological study of paediatric burns in Ain Shams University, Burn Unit, Cairo, Egypt.

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  • (PMID = 19553024.001).
  • [ISSN] 1879-1409
  • [Journal-full-title] Burns : journal of the International Society for Burn Injuries
  • [ISO-abbreviation] Burns
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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18. Walts AE, Lechago J, Hu B, Shwayder M, Sandweiss L, Bose S: P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN). Clin Med Pathol; 2008;1:7-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN).
  • BACKGROUND: Significant variation is reported in the diagnosis of HPV-associated AIN.
  • We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN.
  • This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN.
  • DESIGN: H&E stained slides of 60 anal biopsies were reviewed by three pathologists and consensus diagnoses were achieved: 25 negative, 12 low (condyloma and/or AIN I) and 23 high (9 AIN II and 14 AIN III) grade lesions.
  • RESULTS: Addition of p16 and Ki67 immunostains reduced intra- and interobserver variability, improved concurrence with consensus diagnoses and reduced two-step differences in diagnosis.
  • Negative and high grade AIN diagnoses showed the most improvement in concurrence levels.
  • CONCLUSION: Addition of p16 and Ki67 immunostains is helpful in the diagnosis and grading of AIN.

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  • (PMID = 21876646.001).
  • [ISSN] 1178-1181
  • [Journal-full-title] Clinical medicine. Pathology
  • [ISO-abbreviation] Clin Med Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3159996
  • [Keywords] NOTNLM ; Ki67 / P16 / anal intraepithelial neoplasia (AIN) / condyloma / human papilloma virus (HPV) / interobserver variability / intraobserver variability
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19. Bakr IM, Ismail NA: Domestic violence among women attending out-patient clinics in Ain Shams University Hospitals, Cairo, Egypt. J Egypt Public Health Assoc; 2005;80(5-6):629-50
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  • [Title] Domestic violence among women attending out-patient clinics in Ain Shams University Hospitals, Cairo, Egypt.
  • A descriptive cross sectional study was conducted to determine the prevalence of domestic violence among ever married females presenting to out patient clinics in Ain Shams university hospitals and to identify factors affecting it.
  • This proposes the importance of effective screening, diagnosis and management of domestic violence victims.

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  • (PMID = 17187746.001).
  • [ISSN] 0013-2446
  • [Journal-full-title] The Journal of the Egyptian Public Health Association
  • [ISO-abbreviation] J Egypt Public Health Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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20. Zhang L, Ding L, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates JR 3rd, Han M: Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell; 2007 Nov 30;28(4):598-613
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2.
  • We show that GW182 family proteins AIN-1 and AIN-2 act redundantly to regulate the expression of miRNA targets, but not miRNA biogenesis.
  • Immunoprecipitation (IP) and mass spectrometry indicate that AIN-1 and AIN-2 interact only with miRNA-specific Argonaute proteins ALG-1 and ALG-2 and with components of the core translational initiation complex.
  • Known miRNA targets are enriched in AIN-2 complexes, correlating with the expression of corresponding miRNAs.
  • Combining IP with pyrosequencing and microarray analysis of RNAs associated with AIN-1/AIN-2, we identified 106 previously annotated miRNAs plus nine new candidate miRNAs, but nearly no siRNAs, and more than 3500 potential miRNA targets, including nearly all known ones.

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  • (PMID = 18042455.001).
  • [ISSN] 1097-2765
  • [Journal-full-title] Molecular cell
  • [ISO-abbreviation] Mol. Cell
  • [Language] ENG
  • [Databank-accession-numbers] GENBANK/ AAC24251; GEO/ GSE9073
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM047869; United States / NIGMS NIH HHS / GM / GM047869-15; United States / NCRR NIH HHS / RR / P41 RR011823; United States / NCRR NIH HHS / RR / P41 RR11823; United States / NIGMS NIH HHS / GM / GM47869; United States / NIGMS NIH HHS / GM / R01 GM047869-15
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 3' Untranslated Regions; 0 / AIN-1 protein, C elegans; 0 / AIN-2 protein, C elegans; 0 / Caenorhabditis elegans Proteins; 0 / Carrier Proteins; 0 / Eukaryotic Initiation Factor-4E; 0 / MicroRNAs; 0 / RNA Caps; 0 / RNA, Helminth; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / RNA-Induced Silencing Complex; EC 3.1.- / Endoribonucleases
  • [Other-IDs] NLM/ NIHMS35169; NLM/ PMC2186060
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21. Malanin K, Telegdy E, Qazaq H: Hair loss and serum zinc values among Arab females in Al Ain region, United Arab Emirates. Eur J Dermatol; 2007 Sep-Oct;17(5):446-7
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  • [Title] Hair loss and serum zinc values among Arab females in Al Ain region, United Arab Emirates.

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  • (PMID = 17673393.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Letter
  • [Publication-country] France
  • [Chemical-registry-number] J41CSQ7QDS / Zinc
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22. El-Lamie IK, El Sayed HM, Badawie AG, Bayomi WA, El-Ghazaly HA, Khalaf-Allah AE, El-Mahallawy MN, El-Lamie KI: Evolution of treatment of high-risk metastatic gestational trophoblastic tumors: Ain Shams University experience. Int J Gynecol Cancer; 2006 Mar-Apr;16(2):866-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolution of treatment of high-risk metastatic gestational trophoblastic tumors: Ain Shams University experience.
  • The aim of the current study is to evaluate the different treatment modalities used in the management of high-risk metastatic gestational trophoblastic tumors (GTT) between June 1992 and December 2004 at the Gynecologic Oncology Unit, Ain Shams University.

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  • (PMID = 16681775.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 18D0SL7309 / Chlorambucil; 1CC1JFE158 / Dactinomycin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate; EMA-CO protocol; MDC protocol; PEA-M regimen
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23. Bueno NB, Silva MA, Melo IS, Ataíde Tda R, Oliveira SL, Sant'Ana AE: [Hepatic fatty acid profile of rats with AIN-93 diet-induced steatosis attenuated by the partial substitution of soybean oil by diheptanoin and triheptanoin]. Arq Bras Endocrinol Metabol; 2010 Aug;54(6):584-7
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  • [Title] [Hepatic fatty acid profile of rats with AIN-93 diet-induced steatosis attenuated by the partial substitution of soybean oil by diheptanoin and triheptanoin].
  • [Transliterated title] Perfil em ácidos graxos hepáticos de ratos com esteatose induzida pela dieta AIN-93 atenuada pela substituição parcial do óleo de soja por dieptanoína e trieptanoína.

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  • [CommentOn] Arq Bras Endocrinol Metabol. 2008 Oct;52(7):1145-55 [19082303.001]
  • (PMID = 20857067.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] por
  • [Publication-type] Comment; Letter
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Dietary Fats; 0 / Diglycerides; 0 / Fatty Acids; 0 / Triglycerides; 2P6O7CFW5K / triheptanoin; 8001-22-7 / Soybean Oil
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24. Proceedings from the International Conference on Global Health and the United Arab Emirates: Asia-Middle East Connections, January 2010, Al Ain, Saudi Arabia. Asia Pac J Public Health; 2010 Jul;22(3 Suppl):5S-261S
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  • [Title] Proceedings from the International Conference on Global Health and the United Arab Emirates: Asia-Middle East Connections, January 2010, Al Ain, Saudi Arabia.

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  • (PMID = 20873366.001).
  • [ISSN] 1941-2479
  • [Journal-full-title] Asia-Pacific journal of public health
  • [ISO-abbreviation] Asia Pac J Public Health
  • [Language] ENG
  • [Publication-type] Congresses; Overall
  • [Publication-country] China
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25. Jongen J: Letter to the editor concerning "HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN)" by Varnai et al. (Int J Colorectal Dis 21:135-142, 2006). Int J Colorectal Dis; 2007 Oct;22(10):1289
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Letter to the editor concerning "HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN)" by Varnai et al. (Int J Colorectal Dis 21:135-142, 2006).
  • [MeSH-major] Alphapapillomavirus / isolation & purification. Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology

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  • [CommentOn] Int J Colorectal Dis. 2006 Mar;21(2):135-42 [15864603.001]
  • (PMID = 16703315.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Germany
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26. Al-Naeem AA: Hydrochemical processes and metal composition of Ain Umm-Sabah natural spring in Al-Hassa Oasis Eastern Province, Saudi Arabia. Pak J Biol Sci; 2008 Jan 15;11(2):244-9
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  • [Title] Hydrochemical processes and metal composition of Ain Umm-Sabah natural spring in Al-Hassa Oasis Eastern Province, Saudi Arabia.
  • A total of 10 water samples were collected from Ain Umm Sabah at different times and from different locations from the spring basin.
  • The Ain Umm Sabah water is Na-Cl dominant water and can create soil sodicity problems and cause Na and Cl ion toxicity to plants if used for irrigation of sensitive crops.

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  • (PMID = 18817197.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences : PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Metals
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27. Alsowaidi S, Abdulle A, Bernsen R: Prevalence and risk factors of asthma among adolescents and their parents in Al-Ain (United Arab Emirates). Respiration; 2010;79(2):105-11
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  • [Title] Prevalence and risk factors of asthma among adolescents and their parents in Al-Ain (United Arab Emirates).
  • OBJECTIVES: We investigated the prevalence of asthma and its independent risk factors among adolescents and adults in Al-Ain, UAE.

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19439923.001).
  • [ISSN] 1423-0356
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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28. Al-Muhairi SS, Zoubeidi TA, Ellis ME, Safa WF, Joseph J: Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates. Saudi Med J; 2006 Jul;27(7):1044-8
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  • [Title] Risk factors predicting outcome in patients with pneumonia in Al-Ain, United Arab Emirates.
  • METHODS: We retrospectively analyze the data collected from all inpatients over the age of 16 years with a diagnosis of pneumonia in Tawam Hospital, Al-Ain, United Arab Emirates between the years 1997 and 2002.
  • [MeSH-major] Pneumonia / diagnosis

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  • (PMID = 16830028.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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29. Elshaikh MA, Abdel Hafeez Z, Lu M, Ibrahim D, El Masry T, Yousef A: The effect of androgen deprivation therapy on CD4/CD8 T cells in HIV-negative patients receiving definitive 3D radiation treatment for their prostate carcinoma: Final report of a prospective study. J Clin Oncol; 2009 May 20;27(15_suppl):11056

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of androgen deprivation therapy on CD4/CD8 T cells in HIV-negative patients receiving definitive 3D radiation treatment for their prostate carcinoma: Final report of a prospective study.
  • : 11056 Background: CD4 and CD8 T cells play critical roles in human immunity.
  • The aim of this prospective study is to explore the correlation of the absolute CD4/CD8 T cell counts and total testosterone in patients receiving androgen deprivation therapy (ADT) with goserelin acetate and definitive radiation treatment (RT) for their prostate cancer.
  • METHODS: Thirty-four HIV-negative patients were included in this study between June 2006 and January 2007.
  • All patients had a baseline total testosterone level (T), PSA, CD4 and CD8 T cell counts.
  • CD4/8 T cells count was measured using flow cytometry.
  • All patients received 6 months of ADT prior to (baseline) and during RT to the prostate.
  • Subsequent blood samples were taken at 2, 8, 12 and 24 months.
  • Blood samples were taken between 8-10 am to control for diurnal variations in CD4/CD8 T cell counts and T levels.
  • To study the correlation of T with CD4/8 T cell changes, the Spearman correlation coefficient was calculated.
  • The study was approved by the appropriate Ethics Committee.
  • RESULTS: Median age for the study patients was 68 years.
  • At baseline, median testosterone level was 350 ng/dL, median CD4 T cell count was 1055 mm<sup>3</sup>, and median CD8 T cell count was 644 mm<sup>3</sup>.
  • None of the patients received anti-androgens.
  • At two months, testosterone was at the castrate and subnormal levels in 85% and 100% of the patients, respectively.
  • The lower testosterone levels resulted in significant reduction of CD4 and CD8 T cell counts at 2, 8, 12 and 24 months compared to baseline counts.
  • This effect was more pronounced for CD4 T cells at all time points (p=<0.02).
  • At 24 months, when total testosterone levels were increasing, CD4 and CD8 T cell counts were also following these upward trends.
  • The seen correlation between lower testosterone and decline in CD4 and CD8 T cells was only statistically significant in older patients (>65 years) and was not associated with significant decline in total white blood cell counts.
  • CONCLUSIONS: CD4/CD8 T cell counts are sensitive to changes in total testosterone levels.
  • Lower testosterone levels negatively affecting CD4/CD8 T cells counts at all study time points.
  • Since CD4/CD8 T cells play major roles in cellular immunity, further studies are warranted No significant financial relationships to disclose.

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  • (PMID = 27963161.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Baynouna LM, Revel AD, Nagelkerke NJ, Jaber TM, Omar AO, Ahmed NM, Nazirudeen MK, Al Sayed MF, Nour FA, Abdouni S: Associations of cardiovascular risk factors in Al Ain, United Arab Emirates. Cardiovasc Diabetol; 2009;8:21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Associations of cardiovascular risk factors in Al Ain, United Arab Emirates.
  • METHOD: A community based survey, of conventional risk factors for cardiovascular disease was conducted among 817 national residents of Al Ain city, UAE.

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  • [Cites] Isr Med Assoc J. 2000 Mar;2(3):207-10 [10774268.001]
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  • (PMID = 19371412.001).
  • [ISSN] 1475-2840
  • [Journal-full-title] Cardiovascular diabetology
  • [ISO-abbreviation] Cardiovasc Diabetol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2673216
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31. Yang T, Zhu Y, Ruan Q, Du X, Zeng Y, Xu F: Synthesis of h-AIN nanowires via carbothermal reduction and nitridation method using acetylene black. J Nanosci Nanotechnol; 2010 Jan;10(1):421-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synthesis of h-AIN nanowires via carbothermal reduction and nitridation method using acetylene black.
  • Using acetylene black as an assistant reagent in the ammonia atmosphere, one dimensional (1D) hexagonal single crystalline aluminum nitride (AIN) nanowires were successfully synthesized via carbothermal reduction and nitridation method.
  • With smooth surface and uniform diameter, the wool-like product of AIN nanowires grow along [001] direction and are 80-120 nm in diameter and several tens micrometers in length.
  • Then gaseous Al2O was transported by N2/NH3 mixtures to about 1200 degrees C, where 1D AIN nanowires formed by the reaction of Al2O gas, graphite and NH3.
  • The electrostatic polar charge model and crystallographic characteristics are employed to explain the growth mechanism of AIN nanowires.
  • To our knowledge, acetylene black is the first time to be used for synthesizing 1D AIN nanostructures via carbothermal reduction and nitridation method, which would be an efficient, economical assistant reagent for fabricating nitride nanostructures.

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  • (PMID = 20352872.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Kirsch P, Assouar MB, Elmazria O, Hakiki ME, Mortet V, Alnot P: Combination of e-beam lithography and of high velocity AIN/diamond-layered structure for SAW filters in X band. IEEE Trans Ultrason Ferroelectr Freq Control; 2007 Jul;54(7):1486-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combination of e-beam lithography and of high velocity AIN/diamond-layered structure for SAW filters in X band.
  • In previous work, we have shown that high acoustic velocities (9 to 12 km/s) are obtained from the layered AIN/diamond structure.
  • The interdigital transducers (IDTs) made of aluminium with resolutions up to 250 nm were successfully patterned on AIN/diamond-layered structures with an adapted technological process.
  • The X-ray diffraction effectuated on the AIN/diamond-layered structure exhibits high intensity peaks related to the (002) AIN and (111) diamond orientations.
  • According to the calculated dispersion curves of velocity and the electromechanical coupling coefficient (K2), the AIN layer thickness was chosen in order to combine high velocity and high K2.

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  • (PMID = 17718340.001).
  • [ISSN] 0885-3010
  • [Journal-full-title] IEEE transactions on ultrasonics, ferroelectrics, and frequency control
  • [ISO-abbreviation] IEEE Trans Ultrason Ferroelectr Freq Control
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
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33. Varnai AD, Bollmann M, Griefingholt H, Speich N, Schmitt C, Bollmann R, Decker D: HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis. Int J Colorectal Dis; 2006 Mar;21(2):135-42
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HPV in anal squamous cell carcinoma and anal intraepithelial neoplasia (AIN). Impact of HPV analysis of anal lesions on diagnosis and prognosis.
  • BACKGROUND AND AIMS: Majority of cases of anal squamous cell carcinoma are human papilloma virus (HPV)-induced and result from anal intraepithelial neoplasia (AIN).
  • This study was conducted to examine methods which may enable the routine diagnosis of HPV-induced changes in the anal rim and the consequences of such detection especially in view of a more sensitive diagnosis of AIN.
  • METHODS: The study included biopsy samples from 87 patients who had been diagnosed with the following disease patterns: 47 invasive anal carcinoma, 33 AIN of varying severity and seven condylomatous lesions.
  • RESULTS: In 38 of 47 cases of anal carcinoma, HPV DNA could be detected via PCR (80.9%), the majority of which were HPV 16 (33/38=86.8%).
  • In 29 of the 33 cases of AIN, HPV DNA was detected (87.9%), most of these in AIN III (15/16=93.8%).
  • DISCUSSION: In our series, the clinical diagnosis of the invasive anal carcinoma had a high sensitivity of 93.6%, with a specificity of 80%.
  • In contrast, AIN had been detected clinically in none of the cases.
  • In this situation, especially with high-risk patients, our findings recommend anal HPV screening in combination with anal cytology and anoscopy.
  • CONCLUSION: Based on our results, we urgently recommend for any histological report on excision of anal lesions to include a statement whether histological markers of HPV infection were detected.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Neoplasms / virology. Carcinoma in Situ / virology. Carcinoma, Squamous Cell / virology. DNA, Viral / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Polymerase Chain Reaction. Prognosis. Retrospective Studies

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
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  • [CommentIn] Int J Colorectal Dis. 2007 Oct;22(10):1289 [16703315.001]
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  • (PMID = 15864603.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Viral
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34. Fiedler JL, Villalobos CA, De Mattos AC: An activity-based cost analysis of the Honduras community-based, integrated child care (AIN-C) programme. Health Policy Plan; 2008 Nov;23(6):408-27
MedlinePlus Health Information. consumer health - Children's Health.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An activity-based cost analysis of the Honduras community-based, integrated child care (AIN-C) programme.
  • The Honduras AIN-C programme is a preventive health and nutrition programme of the Honduras Ministry of Health (MOH) that relies on volunteers to help mothers monitor and maintain the adequate growth of young children.
  • This study was undertaken to provide the first comprehensive estimates of the cost of the AIN-C programme, with the goal of providing a programme and financial planning tool for Honduras.
  • An additional comparison of study findings was also undertaken to determine the cost of the AIN-C programme's community-based services relative to a similar facility-based service.
  • (3) the cost of an AIN-C monthly growth monitoring and counselling session per child is 11% of the cost of a traditional MOH, facility-based growth and development consultation per child; and (4) the effect of mothers substituting AIN-C monitor care for MOH facility-based care 'saves' 203 000 outpatient visits a year, with a potential cost saving of $1.66 million, the equivalent of 60% of the recurrent cost of the programme and roughly equal to the annual incremental budget requirements of the programme.

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  • (PMID = 18755734.001).
  • [ISSN] 0268-1080
  • [Journal-full-title] Health policy and planning
  • [ISO-abbreviation] Health Policy Plan
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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35. Parés D, Mullerat J, Pera M: [Anal intraepithelial neoplasia]. Med Clin (Barc); 2006 Nov 18;127(19):749-55
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia].
  • [Transliterated title] Neoplasia intraepitelial anal.
  • Human papillomavirus (HPV) is responsible for anal condylomata, anal intraepithelial neoplasia (AIN) and anal squamous cell carcinoma.
  • AIN is a premalignant condition that can progress to invasive carcinoma through different grades of severity of the disease called AIN I, AIN II and AIN III.
  • This paper looks at the current definition, diagnostic methods and management of AIN.
  • The incidence of AIN has increased significantly in the last decades.
  • The groups at risk are mainly patients with infection with human immunodeficiency virus, immunossuppressed patients and patients affected by HPV related diseases (e.g., cervical cancer or anal condyloma).
  • Accurate diagnosis of AIN lesions consists of accurate grading and disease extension.
  • Low grade AIN (AIN I) or in extensive lesions, follow-up is advised to determine the possible evolution to anal squamous cell carcinoma.
  • In cases of more severe and localized lesions (AIN II and AIN III), surgical resection should be considered if the predictive postoperative morbidity is low.
  • Screening programs for AIN are not currently in place and there might be much effort to study the management of HPV in these patients.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology
  • [MeSH-minor] Anal Canal / pathology. Anal Canal / surgery. Humans

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  • (PMID = 17198654.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 58
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36. Kusunose T, Sakayanagi N, Sekino T, Ando Y: Fabrication and characterization of aluminum nitride/boron nitride nanocomposites by carbothermal reduction and nitridation of aluminum borate powders. J Nanosci Nanotechnol; 2008 Nov;8(11):5846-53
Hazardous Substances Data Bank. CARBON .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In order to fabricate aluminum nitride/boron nitride (AIN/BN) nanocomposites by pressureless sintering, the present study investigated the synthesis of AIN-BN nanocomposite powders by carbothermal reduction and nitridation of aluminum borate powders.
  • Homogeneous mixtures of alumina (Al2O3), boric acid (H3BO3), and carbon powder were used to synthesize AIN/BN nanocomposite powders containing 10 and 20 vol% BN.
  • Aluminum borate was produced by reacting Al2O3 and B2O3 above 800 degrees C, and AIN and turbostratic BN (t-BN) were produced by reacting aluminum borate with carbon powder and nitrogen gas at 1500 degrees C.
  • Carbothermal reduction followed by nitridation yielded an AIN/BN nanocomposite powder composed of nanosized AIN and t-BN.
  • By pressureless sintering nanocomposite AIN/BN powders containing 5 wt% Y22O3, AIN/BN nanocomposites were obtained without compromising the high thermal conductivity and high hardness.

  • Hazardous Substances Data Bank. ALUMINUM COMPOUNDS .
  • Hazardous Substances Data Bank. BORON COMPOUNDS .
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  • (PMID = 19198315.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aluminum Compounds; 0 / Boron Compounds; 0 / Macromolecular Substances; 0 / Powders; 12041-50-8 / aluminum boride; 2U4T60A6YD / boron nitride; 7440-44-0 / Carbon; 7K47D7P3M0 / aluminum nitride
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37. Reeves PG, Leary PD, Gregoire BR, Finley JW, Lindlauf JE, Johnson LK: Selenium bioavailability from buckwheat bran in rats fed a modified AIN-93G torula yeast-based diet. J Nutr; 2005 Nov;135(11):2627-33
Hazardous Substances Data Bank. SELENIUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selenium bioavailability from buckwheat bran in rats fed a modified AIN-93G torula yeast-based diet.
  • The responses produced from buckwheat bran Se were compared with a standard response curve generated by feeding graded amounts of Se as sodium selenite (Na(2)SeO(3); Na selenite) or selenomethionine (SeMet) in a newly reformulated AIN-93G-Torula yeast diet with a more balanced nutrient composition than older diets of this nature.

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  • Hazardous Substances Data Bank. SODIUM SELENITE .
  • Hazardous Substances Data Bank. SELENIUM METHIONINE .
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  • (PMID = 16251622.001).
  • [ISSN] 0022-3166
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Proteins; 964MRK2PEL / Selenomethionine; EC 1.11.1.9 / Glutathione Peroxidase; H6241UJ22B / Selenium; HIW548RQ3W / Sodium Selenite
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38. Torab FC, Amer M, Abu-Zidan FM, Branicki FJ: Perforated peptic ulcer: different ethnic, climatic and fasting risk factors for morbidity in Al-ain medical district, United Arab Emirates. Asian J Surg; 2009 Apr;32(2):95-101

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perforated peptic ulcer: different ethnic, climatic and fasting risk factors for morbidity in Al-ain medical district, United Arab Emirates.
  • PATIENTS AND METHODS: One hundred and nineteen patients admitted to Al-Ain Hospital with PPU between January 2000 and March 2004 was studied retrospectively; two with deficient data were excluded from the analysis.

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  • (PMID = 19423456.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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39. Al-Hammadi S, Al-Maskari F, Bernsen R: Prevalence of food allergy among children in Al-Ain city, United Arab Emirates. Int Arch Allergy Immunol; 2010;151(4):336-42
MedlinePlus Health Information. consumer health - Food Allergy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence of food allergy among children in Al-Ain city, United Arab Emirates.
  • This cross-sectional study was carried out to assess the prevalence of FA among school children aged 6-9 years in Al-Ain city, UAE.
  • METHODS: We used multistage random sampling in order to get a sample of 397 school children whose parents completed a self-administered questionnaire designed to assess the presence or absence of physician diagnosis of FA and other allergic diseases.
  • CONCLUSIONS: The prevalence of FA in Al-Ain city was 8%.

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  • [Copyright] 2009 S. Karger AG, Basel.
  • (PMID = 19851075.001).
  • [ISSN] 1423-0097
  • [Journal-full-title] International archives of allergy and immunology
  • [ISO-abbreviation] Int. Arch. Allergy Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Allergens
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40. Murakami Y, Suzuki J, Samejima K, Kikuchi K, Hascilowicz T, Murai N, Matsufuji S, Oka T: The change of antizyme inhibitor expression and its possible role during mammalian cell cycle. Exp Cell Res; 2009 Aug 1;315(13):2301-11
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Antizyme inhibitor (AIn), a homolog of ODC, binds to antizyme and inactivates it.
  • We report here that AIn increased at the G1 phase of the cell cycle, preceding the peak of ODC activity in HTC cells in culture.
  • During interphase AIn was present mainly in the cytoplasm and turned over rapidly with the half-life of 10 to 20 min, while antizyme was localized in the nucleus.
  • The level of AIn increased again at the G2/M phase along with ODC, and the rate of turn-over of AIn in mitotic cells decreased with the half-life of approximately 40 min.
  • AIn was colocalized with antizyme at centrosomes during the period from prophase through late anaphase and at the midzone/midbody during telophase.
  • Thereafter, AIn and antizyme were separated and present at different regions on the midbody at late telophase.
  • AIn disappeared at late cytokinesis, whereas antizyme remained at the cytokinesis remnant.
  • Reduction of AIn by RNA interference caused the increase in the number of binucleated cells in HTC cells in culture.
  • These findings suggested that AIn contributed to a rapid increase in ODC at the G1 phase and also played a role in facilitating cells to complete mitosis during the cell cycle.

  • Hazardous Substances Data Bank. Eflornithine .
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  • (PMID = 19426728.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Carrier Proteins; 0 / Ornithine Decarboxylase Inhibitors; 0 / Polyamines; 0 / Proteins; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / ornithine decarboxylase antizyme; 0 / ornithine decarboxylase antizyme inhibitor; EC 4.1.1.17 / Ornithine Decarboxylase; SH1WY3R615 / Nocodazole; ZQN1G5V6SR / Eflornithine
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41. Caers J, Peeters P, Vanden Houte K, Sennesael J, Van der Niepen P, Verbeelen D: Acute interstitial nephritis associated with salmonellosis. Eur J Intern Med; 2006 May;17(3):217-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Acute interstitial nephritis (AIN) is a common cause of acute renal failure.
  • We report a case of AIN, confirmed by renal biopsy, that developed in a patient with typhoid fever due to a Salmonella hadar infection.
  • AIN secondary to Salmonella infection is a rare complication that has only been described twice in the literature.
  • Salmonella should be added to the list of possible causes of AIN.

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  • (PMID = 16618461.001).
  • [ISSN] 0953-6205
  • [Journal-full-title] European journal of internal medicine
  • [ISO-abbreviation] Eur. J. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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42. Duffy PH, Lewis SM, Mayhugh MA, Trotter RW, Hass BS, Latendresse JR, Thorn BT, Tobin G, Feuers RJ: Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes. Nutr Res; 2008 Jan;28(1):36-42
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  • [Title] Neoplastic pathology in male Sprague-Dawley rats fed AIN-93M diet ad libitum or at restricted intakes.
  • The primary purpose of this study was to evaluate the effects of age and long-term dietary reduction on neoplastic diseases in rats fed the AIN-93M purified diet.
  • Male Sprague-Dawley rats assigned to 2 groups, ad libitum (AL) and dietary restricted (DR), were fed the AIN-93M (casein protein) diet free choice and reduced in amount by 31%, respectively.

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  • (PMID = 19083386.001).
  • [ISSN] 1879-0739
  • [Journal-full-title] Nutrition research (New York, N.Y.)
  • [ISO-abbreviation] Nutr Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Caseins; 0 / Dietary Proteins
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43. Bean SM, Eltoum I, Horton DK, Whitlow L, Chhieng DC: Immunohistochemical expression of p16 and Ki-67 correlates with degree of anal intraepithelial neoplasia. Am J Surg Pathol; 2007 Apr;31(4):555-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of p16 and Ki-67 correlates with degree of anal intraepithelial neoplasia.
  • Anal intraepithelial neoplasia (AIN) is a human papilloma virus related lesion.
  • The objective of this study is to correlate p16 expression and cellular proliferation measured by Ki-67 staining with the degree of dysplasia in the anal canal and to determine the efficacy of these markers in diagnosing high-grade AIN.
  • Seventy-five anal specimens from 55 patients (37 men; 18 women; mean age: 48 y; median: 44 y; range 25 to 96 y) were studied including 35 normal/reactive lesions, 23 low-grade AIN (AIN I and condyloma), and 17 high-grade AIN (AIN II and III).
  • Expression of p16 in AIN correlated with that of Ki-67 (P<0.001).
  • High-grade AIN often demonstrated p16 staining in more than one-third of the thickness of the epithelium in a diffuse/continuous fashion. p16 expression in low-grade AIN was often restricted to the lower 1/3 of the epithelium and/or was focal and discontinuous.
  • The expression of both p16 and Ki-67 correlated with the degree of dysplasia (P<0.01).
  • When positive p16 staining was defined as the presence of diffuse/continuous staining in more than one-third of the thickness of epithelium, the sensitivity, specificity, and accuracy of p16 as a marker for diagnosing high-grade AIN were 76%, 86%, and 84%, respectively.
  • When positive Ki-67 staining was defined as the presence of nuclear staining in more than 25% of the cells in more than one-third of the thickness of epithelium, the sensitivity, specificity, and accuracy of Ki-67 as a marker for diagnosing high-grade AIN were 71%, 84%, and 83% respectively.
  • Both p16 and Ki-67 are reliable markers for diagnosing high-grade AIN.
  • [MeSH-major] Anus Neoplasms / diagnosis. Genes, p16. Ki-67 Antigen / metabolism. Papillomavirus Infections / diagnosis. Precancerous Conditions / diagnosis. Tumor Virus Infections / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / virology. Female. History, 17th Century. Humans. Immunohistochemistry. Male. Sensitivity and Specificity

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  • (PMID = 17414102.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen
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44. Gohy L, Gorska I, Rouleau D, Ghattas G, Pokomandy Ad, Vézina S, Coté P, Macleod J, Allaire G, Hadjeres R, Kornegay JR, Franco E, HIPVIRG Study Group, Coutlée F: Genotyping of human papillomavirus DNA in anal biopsies and anal swabs collected from HIV-seropositive men with anal dysplasia. J Acquir Immune Defic Syndr; 2008 Sep 1;49(1):32-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genotyping of human papillomavirus DNA in anal biopsies and anal swabs collected from HIV-seropositive men with anal dysplasia.
  • BACKGROUND: Human papillomavirus (HPV) causes anal intraepithelial neoplasia (AIN) in HIV-seropositive men.
  • The detection of HPV genotypes in anal biopsies and swabs was compared.
  • METHODS: HPV DNA was detected in anal swabs and biopsies obtained concurrently from 154 HIV-seropositive men [31 without AIN, 60 low-grade AIN (AIN-1), 62 high-grade AIN (AIN-2,3), and 1 indeterminate AIN] under or eligible to highly active antiretroviral therapy.
  • RESULTS: HPV DNA was detected in 24.2% of normal biopsies compared with 93.5% with AIN-2,3 (P < 0.001) and 88.3% with AIN-1 (P < 0.001).
  • The proportion of biopsies containing multiple genotypes was greater in AIN-1 (n = 21, 35.0%; P = 0.002) and AIN-2,3 (n = 38, 58%; P < 0.001) than in normal biopsies (n = 2, 6.5%).
  • The most frequent genotypes in order of frequency were in AIN-2,3 biopsies HPV-16, 18, 58, and 45 and were in AIN-1 biopsies HPV-6, 11, 16, and 39.
  • Controlling for age, CD4 count, and smoking, the presence of high-risk HPV DNA in biopsies [odds ratio (OR) = 50.8, 95% confidence interval (CI): 13.0 to 199.5] but not in swabs (OR = 2.0, 95% CI: 0.6 to 7.0) was associated with AIN-2,3.
  • CONCLUSIONS: AIN-2,3 was associated with high-risk HPV infection detected in biopsies but not in swabs in men under or starting highly active antiretroviral therapy, possibly due to the presence of HPV foci outside of the neoplastic lesion.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Diseases / virology. Carcinoma in Situ / complications. Carcinoma in Situ / virology. DNA, Viral. HIV Seropositivity / virology

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  • (PMID = 18667921.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Investigator] OAllaire G; Baril JG; Boissonnault M; Charest L; Charron MA; Cote S; Cote P; Coutlee F; de Pokomandy A; Dion H; Dufresne S; Falutz J; Fortin C; Franco E; Ghattas G; Gilmore N; Gorska I; Hadjeres R; Junod P; Klein M; Lalonde R; Laplante F; Leblanc R; Legault D; Lessard B; Longpre D; Mcleod J; Maziade JP; Murphy D; Nguyen VK; O'Brien R; Phaneuf D; Rouleau D; Routy JP; Szabo J; Tessier D; Thomas R; Toma E; Tremblay C; Trepanier JM; Trottier B; Tsoukas C; Turner H; Vezina S
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45. Saadi H, Carruthers SG, Nagelkerke N, Al-Maskari F, Afandi B, Reed R, Lukic M, Nicholls MG, Kazam E, Algawi K, Al-Kaabi J, Leduc C, Sabri S, El-Sadig M, Elkhumaidi S, Agarwal M, Benedict S: Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates. Diabetes Res Clin Pract; 2007 Dec;78(3):369-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates.
  • METHODS: A random sample of houses of Emirati citizens living in Al Ain, UAE was surveyed.
  • RESULTS: There were 2455 adults (>18) living in the 452 surveyed houses of which 10.2% reported having the diagnosis of DM.

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  • (PMID = 17532085.001).
  • [ISSN] 1872-8227
  • [Journal-full-title] Diabetes research and clinical practice
  • [ISO-abbreviation] Diabetes Res. Clin. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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46. Perazella MA, Markowitz GS: Drug-induced acute interstitial nephritis. Nat Rev Nephrol; 2010 Aug;6(8):461-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Acute interstitial nephritis (AIN) is a common cause of acute kidney injury.
  • Many etiologies of AIN have been recognized--including allergic/drug-induced, infectious, autoimmune/systemic, and idiopathic forms of disease.
  • The most common etiology of AIN is drug-induced disease, which is thought to underlie 60-70% of cases.
  • Multiple agents from many different classes of drugs can cause AIN, and the clinical presentation and laboratory findings vary according to the class of drug involved.
  • AIN is characterized by interstitial inflammation, tubulitis, edema, and in some cases, eventual interstitial fibrosis.
  • A definitive diagnosis of AIN can be established only by kidney biopsy.
  • The mainstay of therapy for drug-induced AIN is timely discontinuation of the causative agent.
  • Although the benefits of corticosteroid therapy remain unproven, they do appear to have a positive effect in some patients with drug-induced AIN, especially when treatment is initiated early in the course of the disease.
  • In general, the prognosis for drug-induced AIN is good, and at least partial recovery of kidney function is normally observed.
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Humans

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  • (PMID = 20517290.001).
  • [ISSN] 1759-507X
  • [Journal-full-title] Nature reviews. Nephrology
  • [ISO-abbreviation] Nat Rev Nephrol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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47. Baker CC, Ceylan A, Shah SI: Reactive gas condensation synthesis of aluminum nitride nanoparticles. J Nanosci Nanotechnol; 2006 Jan;6(1):146-50
Hazardous Substances Data Bank. ALUMINUM, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Aluminum Nitride (AIN) nanoparticles were synthesized using a Reactive Gas Condensation (RGC) technique in which a mixture of ammonia (NH3) and nitrogen (N2) gases were used for the nitridation of aluminum.
  • X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analyses revealed that at reactive gas compositions greater than 10% NH3 in N2, samples were composed entirely of hexagonal AIN nanoparticles.
  • Electron diffraction patterns showed single crystal hexagonal AIN structure.
  • AIN nanoparticles were dispersed in a liquid matrix to enhance thermal conductivity.
  • Results showed that a minimal addition of AIN increased the thermal conductivity of hydrocarbon pump oil by approximately 27%.
  • The thermal conductivity became constant after reaching a maximum above 0.01 wt% AIN.
  • Temporal stability of AIN was studied by XRD.
  • Samples exposed to air for extended periods of time and analyzed by XRD show no degradation of crystalline AIN nanoparticles.

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  • (PMID = 16573086.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aluminum Compounds; 0 / Gases; 0 / Metals; 7K47D7P3M0 / aluminum nitride; CPD4NFA903 / Aluminum
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48. Roma AA, Goldblum JR, Fazio V, Yang B: Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma. Int J Clin Exp Pathol; 2008;1(5):419-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma.
  • Recent studies have showed that 14-3-3sigma was silenced transcriptionally through promoter hypermethylation mainly in HPV-negative vulvar squamous cell carcinoma (SCC).
  • However, the expression of 14-3-3sigma protein has not yet been studied in anal SCC and its precursor, anal intraepithelial neoplasm (AIN).
  • In this study, we evaluated the expression of 14-3-3sigma, p16 and p53 in 34 cases of normal perianal squamous mucosa, 5 cases of squamous hyperplasia and 62 cases of AIN, including 54 bowenoid and 8 differentiated AINs.
  • Fourteen cases of invasive anal SCC were also included in the study, including 8 cases associated with bowenoid AIN and 6 cases associated with differentiated AIN.
  • Expression of p16, p53 and 14-3-3sigma proteins was not seen in normal squamous epithelium.
  • Weak staining for 14-3-3sigma was seen in anal squamous hyperplasia.
  • Strong and diffuse p16 immunoreactivity was seen in 98.1% of bowenoid AIN, but only in 12.5% of differentiated AIN.
  • In contrast, increased basal staining with suprabasal extension of p53 was seen in 100% of differentiated AIN, but in none of the bowenoid AIN.
  • Overexpression of 14-3-3sigma was detected in 97% (60/62) of AIN cases, including 96.3% of bowenoid AIN and 100% of differentiated AIN.
  • In conclusion, two histopathologic types of AIN, bowenoid and differentiated, have distinct immunoprofiles for p16 and p53, which suggests dual molecular pathways during anal carcinogenesis.
  • Increased expression of 14-3-3sigma protein was found in approximately 97% of AIN lesions, regardless of histopathologic type and independent of p16 and p53 expression.
  • Our study indicates that immunohistochemical detection of 14-3-3sigma in conjunction with p16 and p53 may be useful in histopathologic recognization of AIN.

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  • (PMID = 18787619.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480570
  • [Keywords] NOTNLM ; 14-3-3σ / AIN / Anal intraepithelial neoplasm / Bowenoid / differentiated / p16 / p53 / simplex
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49. Dunn AJ, Salonen DC, Anastakis DJ: MR imaging findings of anterior interosseous nerve lesions. Skeletal Radiol; 2007 Dec;36(12):1155-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To study and characterise the MR imaging findings of lesions of the anterior interosseous nerve (AIN).
  • MATERIALS AND METHODS: Magnetic resonance imaging (MRI) findings of the forearm of ten patients referred to our institution with suspected AIN lesions were retrospectively studied.
  • Two musculoskeletal radiologists assessed the forearm musculature for oedema in the distribution of the AIN, median, posterior interosseous and radial nerves on T2-weighted (T2W) fat-saturated sequences.
  • RESULTS: Six patients had undergone surgical exploration; five of these had surgically confirmed AIN compression.
  • Four patients had diagnoses other than AIN compression made on imaging features.
  • Of the cases of proven AIN compression, oedema within the pronator quadratus (PQ) muscle was identified in all cases.
  • The four cases of non-AIN compression demonstrated muscle oedema patterns that were atypical for the AIN distribution.
  • CONCLUSIONS: MRI is a useful investigation in the diagnostic workup of AIN syndrome.
  • AIN syndrome is likely when there is diffuse oedema of AIN innervated muscles on T2W fat-saturated images.
  • The most reliable sign of an AIN lesion is oedema within the PQ.
  • Oedema in the flexor carpi radialis, FDP3 and FDP4, although not in the classical distribution of the AIN, does not preclude the diagnosis of AIN syndrome.
  • [MeSH-major] Forearm / innervation. Magnetic Resonance Imaging / methods. Nerve Compression Syndromes / diagnosis. Neuritis / diagnosis

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  • (PMID = 17938918.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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50. Baynouna LM, Revel AD, Nagelkerke NJ, Jaber TM, Omar AO, Ahmed NM, Naziruldeen MK, Al-Sayed MF, Nour FA: High prevalence of the cardiovascular risk factors in Al-Ain, United Arab Emirates. An emerging health care priority. Saudi Med J; 2008 Aug;29(8):1173-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High prevalence of the cardiovascular risk factors in Al-Ain, United Arab Emirates. An emerging health care priority.
  • METHODS: A cross-sectional community based study on established cardiovascular risk factors carried out between February 2004 - February 2005 in Al-Ain City, UAE.

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  • (PMID = 18690314.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
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51. Akhtari M, Curtis B, Waller EK: Autoimmune neutropenia in adults. Autoimmun Rev; 2009 Sep;9(1):62-6
Hazardous Substances Data Bank. RITUXIMAB .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Autoimmune neutropenias (AIN) in adults are a heterogeneous group of diseases with clinical manifestations varying from being asymptomatic to having infectious complications with considerable morbidity and mortality.
  • AIN can be divided into two forms.
  • In primary AIN, neutropenia is usually the sole hematologic abnormality and it is more common in children.
  • Secondary AIN, which is more prevalent in adults, is associated with underlying autoimmune diseases, malignancies, infections, particularly viral, neurological diseases or drug exposure.
  • This article is an overview of these conditions with emphasis on secondary AIN; it also discusses the available serological methods for antibody detection and recent therapeutic developments including colony stimulating factors, rituximab and Campath-1H.

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  • (PMID = 19293004.001).
  • [ISSN] 1873-0183
  • [Journal-full-title] Autoimmunity reviews
  • [ISO-abbreviation] Autoimmun Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Recombinant Proteins; 4F4X42SYQ6 / Rituximab; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
  • [Number-of-references] 39
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52. Abbasakoor F, Boulos PB: Anal intraepithelial neoplasia. Br J Surg; 2005 Mar;92(3):277-90
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  • [Title] Anal intraepithelial neoplasia.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN) is believed to be a precursor of anal squamous cell cancer and its incidence is rising in high-risk groups, particularly those infected with the human immunodeficiency virus (HIV).
  • The natural history of AIN is unclear and management strategies are lacking.
  • METHODS: This review is based on a literature search (Medline and PubMed) with manual cross-referencing of all articles related to AIN.
  • RESULTS AND CONCLUSIONS: The aetiology of AIN is intricately linked with human papilloma viruses.
  • The pathological processes involved in the progression of AIN are becoming clearer but the natural history, particularly the rate of progression to invasive cancer, remains unknown.
  • There is no standard management for AIN and this is mainly due to difficulties in both diagnosis and treatment.
  • Long-term follow-up of these patients is essential until the natural history of AIN becomes clearer.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma in Situ. Carcinoma, Squamous Cell

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  • [Copyright] Copyright (c) 2005 British Journal of Surgery Society Ltd.
  • (PMID = 15736144.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 131
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53. Squintani G, Mezzina C, Lettieri C, Critelli A, Eleopra R: Unusual Parsonage-Turner syndrome with relapses and bilateral simultaneous anterior interosseous neuropathy. Neurol Sci; 2009 Dec;30(6):513-6
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  • We report an unusual case of Parsonage-Turner syndrome with relapses and simultaneous bilateral anterior interosseous neuropathy (AIN).
  • Neurophysiology was consistent with bilateral AIN neuropathy and serology revealed anti-nucleus antibody positivity.
  • Association of relapses with bilateral acute AIN involvement in the subject with autoantibody detection can suggest an immunological pathogenesis.

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  • (PMID = 19685201.001).
  • [ISSN] 1590-3478
  • [Journal-full-title] Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
  • [ISO-abbreviation] Neurol. Sci.
  • [Language] eng
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  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Autoantibodies
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54. Abd Elaziz KM, Bakr IM: Assessment of knowledge, attitude and practice of hand washing among health care workers in Ain Shams University hospitals in Cairo. J Prev Med Hyg; 2009 Mar;50(1):19-25
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  • [Title] Assessment of knowledge, attitude and practice of hand washing among health care workers in Ain Shams University hospitals in Cairo.
  • The aim of this work was to assess the knowledge, attitude and practice of hand washing among health care workers (HCW) in Ain-Shams University hospitals and to investigate the presence of the necessary facilities and supplies required for hand washing (HW) in ten wards.

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  • (PMID = 19771756.001).
  • [ISSN] 1121-2233
  • [Journal-full-title] Journal of preventive medicine and hygiene
  • [ISO-abbreviation] J Prev Med Hyg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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55. Singh JC, Kuohung V, Palefsky JM: Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men. J Acquir Immune Defic Syndr; 2009 Dec 1;52(4):474-9
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  • [Title] Efficacy of trichloroacetic acid in the treatment of anal intraepithelial neoplasia in HIV-positive and HIV-negative men who have sex with men.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), particularly AIN 3 is a precursor to anal cancer.
  • Most cases of AIN are intraanal, but few treatments for intraanal AIN are currently available.
  • Topical 85% trichloroacetic acid (TCA) is an inexpensive method used to treat perianal condyloma, a form of AIN 1, but its efficacy to treat intraanal AIN as first-line therapy is unknown.
  • METHODS: Retrospective review of medical records was performed for all patients with AIN treated at the University of California San Francisco Anal Neoplasia Clinic with TCA as the first-line therapy from January 2000 to December 2004.
  • Clearance was defined as the absence of AIN confirmed by high-resolution anoscopy and cytology after up to 4 TCA treatments.
  • 32% of patients with AIN 2/3 cleared to no lesions.
  • On a per lesion basis, 73% of AIN 1 and 71% AIN 2/3 cleared to no lesion or AIN 1 or less, respectively.
  • A high proportion of AIN 2/3 lesions responded to TCA treatment.

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  • (PMID = 19779306.001).
  • [ISSN] 1944-7884
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000079; United States / NCRR NIH HHS / RR / RR000079-420472; United States / NCRR NIH HHS / RR / UL1 RR024131; United States / NCRR NIH HHS / RR / M01 RR000079-420472
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5V2JDO056X / Trichloroacetic Acid
  • [Other-IDs] NLM/ NIHMS149443; NLM/ PMC2871540
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56. Park JS, Onodera T, Nishimura S, Thompson RF, Itohara S: Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice. Proc Natl Acad Sci U S A; 2006 Apr 4;103(14):5549-54
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  • The anterior interpositus nucleus (AIN) is the proposed site of memory formation of eyeblink conditioning.
  • To elucidate the molecular mechanisms, we examined transcriptional changes in the AIN of mice trained with delay eyeblink conditioning using microarray, quantitative real-time RT-PCR, and in situ hybridization techniques.
  • In situ hybridization revealed increased expression of these genes in broad cerebellar areas, including the AIN, with no hemispheric preferences.
  • In contrast, the expression of representative LATE genes (Vamp1, Camk2d, and Prkcd) was selectively increased in the AIN of the 7-d paired group, with dominance in the ipsilateral AIN.
  • Increased Vamp1 mRNA expression was restricted to the ipsilateral dorsolateral hump, a subregion of the AIN.
  • These expression patterns of two distinct subsets of genes fit well with the two-stage learning theory, which proposes emotional and motor learning phases, and support the notion that AIN has a crucial role in memory formation of eyeblink conditioning.

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  • (PMID = 16569693.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / R01 AG023742; United States / NIA NIH HHS / AG / AG 01451; United States / NIA NIH HHS / AG / AG 023742
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1414800
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57. Baynouna LM, Revel AD, Nagelkerke NJ, Jaber TM, Omar AO, Ahmed NM, Naziruldeen MK, Al Sayed MF, Nour FA, Abdouni S: Secular trend in height in Al Ain-United Arab Emirates. Econ Hum Biol; 2009 Dec;7(3):405-6

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  • [Title] Secular trend in height in Al Ain-United Arab Emirates.

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  • (PMID = 19679519.001).
  • [ISSN] 1873-6130
  • [Journal-full-title] Economics and human biology
  • [ISO-abbreviation] Econ Hum Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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58. Dungarwalla M, Marsh JC, Tooze JA, Lucas G, Ouwehand W, Pettengell R, Dearden CE, Gordon Smith EC, Elebute MO: Lack of clinical efficacy of rituximab in the treatment of autoimmune neutropenia and pure red cell aplasia: implications for their pathophysiology. Ann Hematol; 2007 Mar;86(3):191-7
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  • Six patients had autoimmune neutropenia (AIN), two had pure red cell aplasia (PRCA), one had AIN and autoimmune haemolytic anaemia, one had AIN and immune thrombocytopaenia purpura (ITP) and one had PRCA and ITP.
  • Six of eight patients with AIN and all three patients with PRCA did not respond.
  • Two patients died: one with resistant AIN and autoimmune haemolytic anaemia died of pneumocytis pneumonia infection, and one with PRCA and ITP died of an acute exacerbation of bronchiectasis.
  • Rituximab in AIN and PRCA appears to be less effective than Campath-1H when compared to historical data from our group.
  • This supports the hypothesis that T cells may be important in the pathophysiology of AIN and PRCA.

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  • (PMID = 17123083.001).
  • [ISSN] 1432-0584
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Immunologic Factors; 4F4X42SYQ6 / Rituximab
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59. Decelle L, Cosyns JP, Georges B, Jadoul M, Lefebvre C: Acute interstitial nephritis after cocaine sniffing. Clin Nephrol; 2007 Feb;67(2):105-8
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  • We report the case of a 42-year-old man who developed biopsy-confirmed acute interstitial nephritis (AIN) after cocaine sniffing.
  • AIN should be recognized as a potential cause of acute renal failure in cocaine users, and a history of cocaine use should be carefully elicited in patients with unexplained AIN.
  • [MeSH-minor] Acute Disease. Adult. Biopsy. Diagnosis, Differential. Humans. Male

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  • (PMID = 17338430.001).
  • [ISSN] 0301-0430
  • [Journal-full-title] Clinical nephrology
  • [ISO-abbreviation] Clin. Nephrol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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60. Cörekçi S, Usanmaz D, Tekeli Z, Cakmak M, Ozçelik S, Ozbay E: Surface morphology of Al0.3Ga0.7N/Al2O3-high electron mobility transistor structure. J Nanosci Nanotechnol; 2008 Feb;8(2):640-4
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  • We present surface properties of buffer films (AIN and GaN) and Al0.3Gao.zN/Al2O3-High Electron Mobility Transistor (HEMT) structures with/without AIN interlayer grown on High Temperature (HT)-AIN buffer/Al2O3 substrate and Al2O3 substrate.
  • HT-AIN buffer layer can have a significant impact on the surface morphology of Al0.3Ga0.7N/Al2O3-HEMT structures.

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  • (PMID = 18464384.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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61. Kreuter A, Brockmeyer NH, Hochdorfer B, Weissenborn SJ, Stücker M, Swoboda J, Altmeyer P, Pfister H, Wieland U: Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol; 2005 Apr;52(4):603-8
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  • [Title] Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN) represents a precursor lesion of invasive squamous cell carcinoma with a clear association to high-risk human papillomavirus (HPV) types.
  • HIV infection is strongly associated with a higher prevalence of genital HPV infection, a higher incidence of AIN, and, consecutively, an increased risk for anal cancer.
  • OBJECTIVE: The aim of this study was to determine the clinical spectrum of AIN and lesional HPV colonization in a cohort of homosexual men who were HIV positive and had a history of receptive anal intercourse.
  • RESULTS: Of all patients, 86% had anal HPV infection at their first visit.
  • AIN was diagnosed in 20 of the 103 patients (19.4%).
  • High-risk HPV types were present in all AIN cases with up to 7 different high-risk and up to 5 different low-risk types per lesion.
  • Histologically, 7 (35%), 7 (35%), and 6 (30%) of the patients had AIN grade I, II, or III, respectively.
  • Four different types of clinical presentation could be distinguished in the 20 patients with AIN: bowenoid (1 case, 5%); erythroplakic (2 cases, 10%); verrucous (6 cases, 30%); and leukoplakic (11 cases, 55%).
  • All verrucous lesions were graded as high-grade intraepithelial lesions in cytology, whereas 6 of the 11 leukoplakic lesions (55%) were low grade.
  • All verrucous AIN carried at least 4 different HPV types, always including HPV-16, and the mean number of HPV types was higher in verrucous lesions than in leukoplakic lesions (5.5 vs 3.8, respectively).
  • CONCLUSION: These data confirm the high incidence and prevalence of AIN in patients who are HPV positive with HIV infection.
  • Four different clinical types of AIN can be distinguished that might have prognostic implications.
  • Standardized screening programs for anal cancer prevention and treatment protocols for AIN in patients infected with HIV must be implemented.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. HIV Seropositivity / complications. Papillomaviridae / isolation & purification

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  • (PMID = 15793509.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Hirayama K, Uetsuka K, Kuwabara Y, Tamura M, Itoh K: Vitamin K deficiency of germfree mice caused by feeding standard purified diet sterilized by gamma-irradiation. Exp Anim; 2007 Jul;56(4):273-8
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  • Germfree mice died when they were fed a purified diet of AIN-76 formula sterilized by gamma-irradiation.
  • Germfree mice were fed purified diets of AIN-76 or AIN-93M formula, which were pelleted and sterilized by gamma-irradiation at a dose of 50 kGy.
  • One half of the mice fed the AIN-76 diet died within two weeks and the surviving animals were also in poor health, while 91% of mice fed the AIN-93M diet survived.
  • Histologically, degeneration with inflammatory cell infiltration was observed as well as hemorrhage and fibrosis in the heart muscles of mice fed the AIN-76 diet.
  • Prothrombin time (PT) and activated partial thromboplastin time (APTT) were extremely prolonged when mice were fed the AIN-76 diet.
  • The animals totally recovered when they were intragastrically administered 1 microg/day of vitamin K(3) from the third day of feeding of the AIN-76 diet, except for PT and APTT which were still slightly longer than in mice fed the AIN-93M diet.
  • The concentration of vitamin K(3) supplied in the AIN-76 diet decreased to an undetectable level after gamma-irradiation, while the AIN-93M diet contained 240 microg/kg of vitamin K(1).
  • These results indicate that the deaths of the germfree mice fed the gamma-irradiated AIN-76 diet were caused by vitamin K deficiency.

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  • (PMID = 17660681.001).
  • [ISSN] 1341-1357
  • [Journal-full-title] Experimental animals
  • [ISO-abbreviation] Exp. Anim.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 723JX6CXY5 / Vitamin K 3; 84-80-0 / Vitamin K 1
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63. Mahto M, Nathan M, O'Mahony C: More than a decade on: review of the use of imiquimod in lower anogenital intraepithelial neoplasia. Int J STD AIDS; 2010 Jan;21(1):8-16
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  • [Title] More than a decade on: review of the use of imiquimod in lower anogenital intraepithelial neoplasia.
  • To assess the effectiveness of 5% imiquimod cream (IQ) in the treatment of vulvar, penile and anal intraepithelial neoplasias (VIN, PIN and AIN), we searched Medline, Embase, PubMed and Cochrane Library databases.
  • Use of IQ in PIN and AIN were only supported by cohort studies (two each for PIN and AIN) and case reports (15 for PIN and 3 for AIN).
  • On pooled analysis of RCTs, uncontrolled and cohort studies, the mean complete response (CR) rate for VIN, PIN and AIN were 51%, 70% and 48%, respectively.
  • The mean partial response (PR) rate for VIN, PIN and AIN were 25%, 30% and 34% respectively.
  • The recurrence (RR) rate for VIN, PIN and AIN were 16%, 0% and 36%, respectively.
  • The follow-up period for VIN, PIN and AIN ranged from 2 to 32 months, 10 to 12 months and 11 to 39 months, respectively.
  • Although the results for PIN look the best, the strongest evidence regarding efficacy of IQ in anogenital intraepithelial neoplasia is for VIN supported by RCTs.
  • Evidence for use of IQ in AIN was essentially limited to HIV-positive men who have sex with men.
  • [MeSH-major] Adjuvants, Immunologic / therapeutic use. Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. Penile Neoplasms / drug therapy. Vulvar Neoplasms / drug therapy

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  • (PMID = 20029061.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
  • [Number-of-references] 69
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64. Lane SW, Hassell P, Kennedy GA, Fung YL, Williams BA: Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia. Int J Lab Hematol; 2009 Oct;31(5):567-71

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It may be used to differentiate childhood autoimmune neutropenia (AIN) from other causes of childhood neutropenia, even when circulating neutrophil counts are low.
  • We sought to characterize the diagnostic utility of the BMIFT in childhood AIN.
  • Patients were classified as AIN or nonautoimmune causes.
  • There were 45 patients diagnosed with AIN, 28 with nonimmune neutropenia and three failed tests.
  • The median age of children with AIN was 1.2 years (range 0.3-15.3), compared with 3.6 years (range 0.1-15.7) in the nonautoimmune group.
  • The median neutrophil count in AIN was 0.3 x 10(9)/l (0.9 x 10(9)/l in nonautoimmune).
  • BMIFT was positive in 24 of 45 patients with AIN and 0 of 28 with nonautoimmune neutropenia (sensitivity 53%, specificity 100%, positive predictive value (PPV) 100%, negative predictive value 57%).
  • Ten patients had other autoimmune diatheses at diagnosis.
  • The BMIFT is a simple, highly specific test with excellent PPV and thus is a clinically useful test to confirm AIN in children.
  • [MeSH-major] Autoantibodies / immunology. Bone Marrow / immunology. Fluorescent Antibody Technique. Neutropenia / diagnosis

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  • (PMID = 18637806.001).
  • [ISSN] 1751-553X
  • [Journal-full-title] International journal of laboratory hematology
  • [ISO-abbreviation] Int J Lab Hematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Autoantibodies
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65. Tubbs RS, Custis JW, Salter EG, Wellons JC 3rd, Blount JP, Oakes WJ: Quantitation of and superficial surgical landmarks for the anterior interosseous nerve. J Neurosurg; 2006 May;104(5):787-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: There are scant data regarding the anterior interosseous nerve (AIN) in the neurosurgical literature.
  • In the current study the authors attempt to provide easily identifiable superficial osseous landmarks for the identification of the AIN.
  • METHODS: The AIN in 20 upper extremities obtained in adult cadaveric specimens was dissected and quantified.
  • The AIN originated from the median nerve at mean distances of 5.4 cm distal to the medial epicondyle of the humerus and 21 cm proximal to the ulnar styloid process.
  • The distance from the origin of the AIN to its branch leading to the flexor pollicis longus muscle and to the point it travels deep to the pronator quadratus (PQ) muscle measured a mean 4 and 14.4 cm, respectively.
  • The mean distance from the AIN branch leading to the flexor pollicis longus muscle to the proximal PQ muscle was 12.1 cm, and the mean distance between this branch and the ulnar styloid process was 7.2 cm.
  • The mean diameter of the AIN was 1.6 mm at the midforearm.
  • CONCLUSIONS: Additional landmarks for identification of the AIN can aid the neurosurgeon in more precisely isolating this nerve and avoiding complications.
  • Furthermore, after quantitation of this nerve, the AIN branches can be easily used for neurotization of the median and ulnar nerves, and with the aid of a transinterosseous membrane tunneling technique, passed to the posterior interosseous nerve.

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  • (PMID = 16703884.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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66. Chung AP, Rosenfeld DB: Intraoperative high-resolution anoscopy: a minimally invasive approach in the treatment of patients with Bowen's disease and results in a private practice setting. Am Surg; 2007 Dec;73(12):1279-83
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  • Anal intraepithelial neoplasia III (AIN III) is a risk factor for anal cancer with poor curative results and high morbidity.
  • High-resolution anoscopy (HRA) is a minimally invasive means of identifying and treating AIN III early.
  • We retrospectively reviewed HRA in the treatment of AIN III in a community setting.
  • From January 2002 through November 2005, 76 patients with AIN III diagnosed by anal Pap smear, colposcopy, or biopsy underwent HRA for diagnosis and treatment.
  • Twenty-one patients with AIN III on initial HRA underwent follow-up HRA for reassessment and treatment at 6 months.
  • Twelve of 21 (57%) had intraanal recurrence/persistence; nine of 21 (43%) had no AIN III.
  • HRA is an alternative tool to treat AIN III and can be performed in a community setting yielding results comparable to the university setting.
  • As the prevalence of AIN III increases, it will be more important for community surgeons to treat AIN III with HRA.
  • [MeSH-minor] Adult. Aged. Anal Canal. Community Health Services. Follow-Up Studies. Humans. Male. Middle Aged. Private Practice. Retrospective Studies. Treatment Outcome

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  • (PMID = 18186390.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Li Y, Yang Z, Chen Z, Zhou Z: Computational investigation on structural and physical properties of AIN nanosheets and nanoribbons. J Nanosci Nanotechnol; 2010 Nov;10(11):7200-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Computational investigation on structural and physical properties of AIN nanosheets and nanoribbons.
  • Through first-principles computations, we investigated the structural, electronic and magnetic properties of two-dimensional AIN single layer and one-dimensional AIN nanoribbons.
  • AIN single layer and nanoribbons quit the Wurtzite configuration and adopt a graphitic-like structure after geometry optimization.
  • Both hydrogen-terminated zigzag and armchair AIN nanoribbons have a direct band gap, which increases monotonically with increasing ribbon width.
  • Bare zigzag AIN nanoribbons have a spin-polarized ground state and are magnetic semiconductors.
  • The results may promote the experimental preparation of AIN nanosheets and nanoribbons and their applications to nanotechnology.

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  • (PMID = 21137897.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Scholefield JH, Castle MT, Watson NF: Malignant transformation of high-grade anal intraepithelial neoplasia. Br J Surg; 2005 Sep;92(9):1133-6
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  • [Title] Malignant transformation of high-grade anal intraepithelial neoplasia.
  • BACKGROUND: The natural history of anal intraepithelial neoplasia (AIN) is uncertain.
  • METHODS: All patients were diagnosed with high-grade AIN (AIN III) between 1994 and 2003.
  • Diagnosis was by full-thickness biopsy and histopathological examination.
  • Excision of localized high-grade AIN was carried out in 28 patients with minimal morbidity.
  • Six patients were systemically immunosuppressed at diagnosis, all of whom had multifocal perianal lesions.
  • Three immunosuppressed patients developed invasive anal squamous carcinoma during follow-up.
  • By contrast, no invasive carcinomas were identified among immunocompetent patients with either localized or multifocal perianal disease.
  • CONCLUSION: AIN III appears to have a relatively low potential for malignant transformation in the immunocompetent patient.
  • However, immunosuppressed patients are more likely to have extensive AIN III and a greater risk of malignant change.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Cell Transformation, Neoplastic / pathology
  • [MeSH-minor] Adult. Carcinoma, Squamous Cell / pathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local. Prospective Studies

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  • [Copyright] Copyright 2005 British Journal of Surgery Society Ltd.
  • (PMID = 16044425.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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69. Watson AJ, Smith BB, Whitehead MR, Sykes PH, Frizelle FA: Malignant progression of anal intra-epithelial neoplasia. ANZ J Surg; 2006 Aug;76(8):715-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant progression of anal intra-epithelial neoplasia.
  • BACKGROUND: Anal intra-epithelial neoplasia (AIN) is believed to be a precursor to squamous cell carcinoma of the anus.
  • The risk of developing anal cancer in patients with AIN, although known to occur, has been thought to be relatively low.
  • This study reviews our experience with AIN, reviewing the incidence and risk factors for development of invasive malignancy and the outcome of present management strategies.
  • METHODS: This study examined a cohort of 72 patients identified from a prospective database with AIN from a single institution between January 1996 and December 2004.
  • We identified progression of AIN to invasive malignancy in eight patients despite undergoing surveillance.
  • CONCLUSION: This study has shown a high rate of progression to invasive malignancy (11%) with AIN despite surveillance.
  • The patients at risk of developing squamous cell carcinoma were the immunocompromised and those with genital intra-epithelial field change.
  • Treatment of AIN has significant complications and despite treatment, invasive cancers do occur.
  • Decisions made for treatment of AIN can affect treatment choices if invasive malignancy develops.
  • [MeSH-major] Anus Neoplasms / epidemiology. Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / epidemiology

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  • (PMID = 16916390.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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70. Bernard JE, Butler MO, Sandweiss L, Weidner N: Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization. Appl Immunohistochem Mol Morphol; 2008 May;16(3):215-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization.
  • Accurate diagnosis and grading of anal intraepithelial neoplasia (AIN) can be problematic, especially in separating AIN from anal transitional-zone epithelium.
  • To investigate if p16 would help in more accurately diagnosing and grading AIN, particularly when attempting to distinguish benign transitional-zone epithelium from high-grade AIN, we separately assessed these stains in a blinded manner on a large number of consecutive anal biopsies and anal tissues and correlated the findings with the diagnosis and grade of AIN.
  • One hundred thirty-three consecutive anal tissue specimens, from 128 patients were studied.
  • One hundred and eight were anal biopsies and 25 were hemorrhoidectomy specimens.
  • The comparisons included AIN grade (negative, 1, 2, 3) with nuclear intensity of p16 IHC (0 to 3+), AIN grade with IHC nuclear staining patterns (contiguous, patchy/rare), AIN grade with HPV-ISH [negative, low-risk (LR), high-risk (HR)] and, nuclear intensity of p16 IHC with HPV-ISH.
  • Yet, 33% of AIN negative cases were positive for nuclear p16, although with less nuclear intensity than for AIN2 or 3.
  • The kappa value for AIN/nuclear p16 intensity agreement was 0.61 (ie, substantial agreement).
  • Yet, 12.5% of AIN negative cases were positive for HPV for both LR and HR types.
  • The kappa value for AIN/HPV agreement was 0.62 (ie, substantial agreement).
  • Of interest, 30 cases were negative for AIN and p16 staining and of these, 2 (7%) were positive for HPV (both LR subtype).
  • Three cases positive for HR HPV were negative for AIN with only patchy nuclear p16 positivity.
  • We conclude that the correlation between AIN and p16 and HPV is strong enough to be quite useful in distinguishing true AIN from benign mimics, such as benign transitional-zone epithelium.

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  • (PMID = 18301250.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA Probes, HPV
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71. Richel O, Wieland U, de Vries HJ, Brockmeyer NH, van Noesel C, Potthoff A, Prins JM, Kreuter A: Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men. Br J Dermatol; 2010 Dec;163(6):1301-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Topical 5-fluorouracil treatment of anal intraepithelial neoplasia in human immunodeficiency virus-positive men.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-induced potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM).
  • So far, only a few prospective studies have been performed on the topical treatment of AIN, especially at the intra-anal location.
  • OBJECTIVES: To evaluate the efficacy and safety of self-administered topical 5-fluorouracil (5-FU) treatment of AIN in HIV-positive MSM.
  • METHODS: High-resolution anoscopy (HRA) was performed and patients with AIN (grade 1-3) were treated with 5-FU twice weekly for a total of 16 weeks.
  • RESULTS: A total of 46 patients with AIN were included in this open prospective pilot study; 76% had multifocal disease and 74% had high-grade lesions (AIN 2 or 3).
  • Eighteen patients (39%) had a complete clearance of AIN and eight patients (17%) had a partial response.
  • Seventeen patients (37%) did not respond (unchanged grade of AIN in 16 patients and progression from low- to high-grade AIN in one patient).
  • CONCLUSIONS: A substantial proportion of HIV-positive MSM with AIN completely cleared their lesions with topical 5-FU treatment.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Anus Neoplasms / drug therapy. Fluorouracil / therapeutic use. HIV Infections / complications

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  • [Copyright] © 2010 The Authors. BJD © 2010 British Association of Dermatologists.
  • (PMID = 20716208.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; U3P01618RT / Fluorouracil
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72. Palefsky JM, Holly EA, Efirdc JT, Da Costa M, Jay N, Berry JM, Darragh TM: Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS; 2005 Sep 2;19(13):1407-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men.
  • OBJECTIVES: The incidence of anal cancer among men who have sex with men (MSM) has continued to increase since the introduction of highly active antiretroviral therapy (HAART).
  • The prevalence of the putative anal cancer precursor, anal intraepithelial neoplasia (AIN) was high among HIV-positive MSM prior to the availability of HAART but little is known about AIN since HAART was introduced.
  • We characterized the prevalence of AIN among HIV-positive MSM and examined the association between AIN and various factors including use of HAART.
  • DESIGN AND METHODS: A baseline point-prevalence analyses in a prospective cohort study of AIN was performed at a university-based research clinic.
  • A total of 357 HIV-positive MSM with no history of anal cancer completed a questionnaire detailing behaviors and medical history, anal cytology and human papillomavirus (HPV) testing, and high-resolution anoscopy with biopsy for detection of AIN.
  • RESULTS: Eighty-one percent of participants with available CD4+ cell counts at baseline had AIN of any grade; 52% had AIN 2 or 3; and 95% had anal HPV infection.
  • In multivariate analysis, detection of > or = 6 HPV types [odds ratio (OR), 36; 95% confidence interval (CI), 7.4-171) and use of HAART (OR, 10; 95% CI, 2.6-38) were associated with AIN after adjustment for length of time participants were HIV-positive, CD4+ cell count and HIV viral load.
  • CONCLUSIONS: The prevalence of AIN has remained high among HIV-positive MSM after the introduction of HAART.
  • Our data indicate that HAART is not associated with a reduced prevalence of AIN and support measures to prevent anal cancer among HIV-positive MSM whether or not they are using HAART.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. HIV Infections / complications. Homosexuality, Male

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  • (PMID = 16103772.001).
  • [ISSN] 0269-9370
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / R01CA54053
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-HIV Agents
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73. Joaquim AI, Mendes GE, Ribeiro PF, Baptista MA, Burdmann EA: Ga-67 scintigraphy in the differential diagnosis between acute interstitial nephritis and acute tubular necrosis: an experimental study. Nephrol Dial Transplant; 2010 Oct;25(10):3277-82

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ga-67 scintigraphy in the differential diagnosis between acute interstitial nephritis and acute tubular necrosis: an experimental study.
  • BACKGROUND: The differentiation between acute interstitial nephritis (AIN) and acute tubular necrosis (ATN) is crucial in patients with acute kidney injury.
  • Gallium-67 citrate (Ga-67) has been used clinically in the differential diagnosis between these entities, but its efficacy is disputed.
  • The aim of this study was to evaluate Ga-67 scintigraphy efficacy in the differentiation between experimental models of drug-induced AIN and ATN.
  • METHODS: Animals were divided into three groups: AIN (n = 8), ATN (n = 8) and control (NL, n = 10).
  • The AIN group received intraperitoneal puromycin aminonucleoside (single dose, 150 mg/kg).
  • RESULTS: Renal Ga-67 uptake was strikingly more intense in the AIN group when compared to the ATN (P < 0.0001) and NL (P < 0.001) groups.
  • The ATN group had increased Cr when compared to the NL group (P < 0.001) and lower urinary osmolality vs the NL (P < 0.001) and AIN (P < 0.01) groups.
  • Renal histology showed severe acute tubular injury in the ATN group and intense interstitial inflammation in the AIN group, and was normal in control animals.
  • CONCLUSION: Ga-67 scintigraphy was extremely effective in the differentiation between experimental drug-induced ATN and AIN.
  • [MeSH-minor] Acute Disease. Acute Kidney Injury / radionuclide imaging. Animals. Diagnosis, Differential. Kidney / pathology. Kidney / physiopathology. Male. Rats. Rats, Wistar

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  • (PMID = 20348147.001).
  • [ISSN] 1460-2385
  • [Journal-full-title] Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • [ISO-abbreviation] Nephrol. Dial. Transplant.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Gallium Radioisotopes
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74. Chin-Hong PV, Berry JM, Cheng SC, Catania JA, Da Costa M, Darragh TM, Fishman F, Jay N, Pollack LM, Palefsky JM: Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men. Ann Intern Med; 2008 Sep 2;149(5):300-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men.
  • BACKGROUND: Human papillomavirus (HPV)-associated anal cancer is increasing in prevalence and is more common among men who have sex with men and HIV-positive individuals than cervical cancer is among women in the United States.
  • Cytology screening can detect the anal cancer precursor, anal intraepithelial neoplasia (AIN).
  • Little is known about self-collected samples for AIN screening, and few community-based AIN estimates exist.
  • OBJECTIVE: To compare the sensitivity of self-collected versus clinician-collected anal cytology specimens to detect biopsy-confirmed AIN and the prevalence estimate of AIN in a community sample.
  • Participants were mailed anal cytology self-collection kits with instructions.
  • Clinicians repeated anal cytology and performed high-resolution anoscopy with biopsies as the diagnostic reference standard.
  • MEASUREMENTS: Prevalence of anal HPV and AIN.
  • Sensitivity and specificity of self-collected and clinician-collected anal cytology specimens to diagnose AIN were calculated.
  • RESULTS: Biopsy-proven AIN was diagnosed in 57% of HIV-positive and 35% of HIV-negative participants (P = 0.04), and 80% provided adequate self-collected specimens for interpretation.
  • The sensitivity of cytology to detect AIN in HIV-positive men was 75% (95% CI, 51% to 93%) when self-collected and 90% (CI, 68% to 99%) when clinician-collected; respective values in HIV-negative men were 48% (CI, 26% to 70%) and 62% (CI, 38% to 82%).
  • The specificity of cytology to detect AIN in HIV-positive men was 50% (CI, 22% to 78%) when self-collected and 64% (CI, 36% to 86%) when clinician-collected; respective values in HIV-negative men were 86% (CI, 71% to 94%) and 85% (CI, 72% to 93%).
  • CONCLUSION: In a community-based sample, a high proportion of HIV-positive and HIV-negative men who have sex with men have AIN.
  • The sensitivity of cytology to detect AIN is higher for clinician-collected versus self-collected specimens and for HIV-positive versus HIV-negative men.
  • The specificity of cytology to detect AIN is higher in HIV-negative versus HIV-positive men.
  • However, the probability of AIN in a patient with a negative cytology result may not be low enough (23% for HIV-negative men and 45% for HIV-positive men with a patient-collected specimen) for clinicians to be comfortable recommending no anoscopy for those with a negative cytology result if done as a one-time test.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Cytological Techniques / methods. Homosexuality. Papillomavirus Infections / pathology. Specimen Handling / methods
  • [MeSH-minor] Adult. Aged. Anal Canal / pathology. Biopsy. Endoscopy, Gastrointestinal. HIV Seronegativity. HIV Seropositivity / epidemiology. HIV Seropositivity / pathology. HIV Seropositivity / virology. Humans. Male. Middle Aged. Prevalence. San Francisco / epidemiology. Sensitivity and Specificity

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  • [CommentIn] Ann Intern Med. 2009 Feb 17;150(4):283-4; author reply 284-5 [19221387.001]
  • [SummaryForPatientsIn] Ann Intern Med. 2008 Sep 2;149(5):I38 [18765696.001]
  • (PMID = 18765699.001).
  • [ISSN] 1539-3704
  • [Journal-full-title] Annals of internal medicine
  • [ISO-abbreviation] Ann. Intern. Med.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NIAID NIH HHS / AI / K23 AI054157; United States / NIAID NIH HHS / AI / R01 CA/AI 88739; United States / NCI NIH HHS / CA / R01 CA54053; United States / NIMH NIH HHS / MH / R01 MH54320
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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75. Härmark L, van der Wiel HE, de Groot MC, van Grootheest AC: Proton pump inhibitor-induced acute interstitial nephritis. Br J Clin Pharmacol; 2007 Dec;64(6):819-23

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To investigate the association between the use of proton pump inhibitors (PPIs) and acute interstitial nephritis (AIN).
  • METHODS: The Netherlands Pharmacovigilance Centre Lareb received seven case reports of AIN induced by various PPIs.
  • In five of the reports it was mentioned that the diagnosis was confirmed by a renal biopsy.
  • Within 12 h of re-exposure the patient developed symptoms of AIN.
  • CONCLUSIONS: The mechanism of drug-induced AIN is unknown, but an immunological mechanism is suspected.
  • Our reports show no relation between dosage, latency, time to recovery, age or gender, supporting the hypothesis that the aetiology of AIN is immunological.
  • Lareb has received reports of AIN with the use of omeprazole, pantoprazole and rabeprazole.
  • This shows that AIN is a complication associated with the whole group of PPIs and not only omeprazole.
  • It is important for health professionals to be aware of this adverse drug reaction, because an accurate and timely diagnosis and withdrawal of the offending drug can prevent potentially life-threatening renal failure.
  • [MeSH-major] Nephritis, Interstitial / chemically induced. Nephritis, Interstitial / diagnosis. Proton Pump Inhibitors / adverse effects

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  • [Cites] Nephrology (Carlton). 2006 Oct;11(5):381-5 [17014549.001]
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  • (PMID = 17635502.001).
  • [ISSN] 1365-2125
  • [Journal-full-title] British journal of clinical pharmacology
  • [ISO-abbreviation] Br J Clin Pharmacol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Proton Pump Inhibitors
  • [Other-IDs] NLM/ PMC2198775
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76. Kreuter A, Brockmeyer NH, Altmeyer P, Wieland U, German Competence Network HIV/AIDS: Anal intraepithelial neoplasia in HIV infection. J Dtsch Dermatol Ges; 2008 Nov;6(11):925-34
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  • [Title] Anal intraepithelial neoplasia in HIV infection.
  • In HIV-infected men who have sex with men (MSM), anal HPV prevalence is more than 90% and infections with multiple HPV types are common.
  • Anal intraepithelial neoplasia (AIN) is a potential precursor lesion of squamous cell carcinoma of the anus.
  • Like its cervical counterpart, cervical intraepithelial neoplasia (CIN), AIN is causally linked to persistent infections with high-risk HPV types such as HPV16 or HPV18.
  • As AIN and CIN share distinct biological similar-ities, AIN screenings analogous to Pap smear programs for CIN have been recommended in high-risk populations to reduce the incidence of anal carcinoma.
  • These screenings include cytological analysis followed by high resolution anoscopy in case of anal dysplasia.
  • Treatment guidelines for AIN are not yet available.
  • However, controlled studies on AIN treatment have not been performed.
  • The impact of HPV vaccination on AIN development will also need to be assessed.
  • [MeSH-major] Anus Neoplasms / diagnosis. Anus Neoplasms / therapy. HIV Infections / diagnosis. HIV Infections / therapy. Papillomavirus Infections / diagnosis. Papillomavirus Infections / therapy. Skin Neoplasms / diagnosis. Skin Neoplasms / therapy

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  • (PMID = 18410393.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 46
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77. Grafe MW, Kim PD, Rosenwasser MP, Strauch RJ: Wrist denervation and the anterior interosseous nerve: anatomic considerations. J Hand Surg Am; 2005 Nov;30(6):1221-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Wrist denervation via resection of the distal anterior interosseous nerve (AIN) and the posterior interosseous nerve (PIN) is an effective treatment for chronic wrist pain.
  • When performing this procedure through a dorsal approach we have been impressed by anatomic variations of the AIN.
  • The purpose of this study was to elucidate the anatomy of the AIN and PIN as encountered through a dorsal distal forearm incision.
  • A dorsal approach to the distal forearm was made to identify the anatomy of the PIN and AIN.
  • The location and diameter of all AIN branches were noted by using an operating stereoscopic microscope at x 25 magnification and a precision caliper.
  • RESULTS: The anatomy of the AIN was variable.
  • The average AIN diameter proximal to the PQ was 1.5 mm.
  • The average number of AIN motor branches was 4.2.
  • CONCLUSIONS: Resection of the AIN at a point 4 cm proximal to the proximal point of the ulnar head would denervate completely the PQ in our cadaver population.
  • Division of the AIN 2 cm proximal to the ulnar head would spare most of the PQ motor branches.

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  • (PMID = 16344179.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Kreuter A, Potthoff A, Brockmeyer NH, Gambichler T, Stücker M, Altmeyer P, Swoboda J, Pfister H, Wieland U, German Competence Network HIV/AIDS: Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men. J Invest Dermatol; 2008 Aug;128(8):2078-83
Hazardous Substances Data Bank. Imiquimod .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men.
  • Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated precursor lesion of anal carcinoma, is highly prevalent in HIV-infected men having sex with men (MSM).
  • This prospective follow-up study evaluated the long-term results of imiquimod treatment of AIN in 19 HIV-infected MSM.
  • Standardized follow-up examinations included high-resolution anoscopy, anal cytology/histology, HPV typing, and DNA load determination for HPV types 16, 18, 31, and 33.
  • A total of 74% (14/19) of the patients remained free of AIN at the previously treated site.
  • Five patients (26%) had recurrent high-grade AIN after a mean time of 24.6 months.
  • During follow-up, 58% of all patients (11/19) developed new anal cytological abnormalities in previously normal, untreated anal regions.
  • 55% of these new AIN lesions were high-grade lesions and most of them were located intra-anally and associated with high-risk HPV types not detectable before therapy.
  • These results demonstrate that imiquimod leads to a high rate of long-term clearance of AIN in HIV-positive men together with a prolonged decrease of high-risk HPV-DNA load.
  • However, new AIN lesions associated with previously undetected HPV types frequently occur in untreated areas.
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. DNA, Viral / drug effects. HIV Infections / complications. Papillomaviridae / genetics

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  • (PMID = 18273049.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / DNA, Viral; 99011-02-6 / imiquimod
  • [Investigator] Adam A; Schewe K; Weitner L; Aratesh K; Arendt G; Bartz C; Behrens G; Beichert M; Bieniek B; Cordes C; Bochow M; Brockmeyer N; Buchholz B; Bogner JR; Buhk T; Clad A; Dannecker M; Dupke S; von Einsiedel R; Esser S; Faetkenheuer G; Fischer K; Freiwald M; Friebe-Hoffmann U; Fenske S; Funk M; Ganschow R; Gingelmaier A; Glaunsinger T; Goebel FD; Gölz J; Grosch-Wörner I; Haberl A; Hamouda O; Harrer T; Hartmann M; Hartl H; Hölscher M; Hower M; Husstedt IW; Jansen K; Jäger H; Jessen H; Jessen A; Karwat M; Klausen G; Kirchhoff F; Knechten H; Köppe S; Kreuter A; Kuhlmann B; Langer P; Lauenroth-Mai; Lehmacher W; Lehmann M; Levin C; Lübke M; Maschke M; Marcus U; Mauss S; Meyerhans A; Meyer-Olson D; ter Meulen V; Michalik C; Moll A; Mosthaf FA; Mutz A; Neuen-Jacob E; Niehues T; Oette M; Paulus U; Plettenberg A; Potthoff A; Racz P; Racz K; Rasokat H; Rausch M; Reichelt D; Reitter A; Rieke A; Rockstroh J; Salzberger B; Schafberger A; Schauer J; Schlote F; Schmidt B; Schranz D; Scholten S; Schuler C; Schwab M; Schmidt W; Schmidt R; Schwarze S; Siffert W; Skaletz-Rorowski A; Sonnenberg-Schwan U; Sopper S; Spengler U; Staszewski S; Steffan E; Stellbrink HJ; Stoll M; Goecke T; Taubert S; Telschik A; Ulmer A; Ullrich R; Uberla K; Usadel S; Vogel M; Wagner R; Walter H; Warnatz K; Wasem J; Wiesel W; Von Weizsäcker K; Wieland U; Wintergerst U; Wolf E; Wolf H; Wünsche T; Wyen Ch; Zeitz M; Zylka-Menhorn V
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79. Lupp C, Ruby EG: Vibrio fischeri uses two quorum-sensing systems for the regulation of early and late colonization factors. J Bacteriol; 2005 Jun;187(11):3620-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Vibrio fischeri possesses two quorum-sensing systems, ain and lux, using acyl homoserine lactones as signaling molecules.
  • We have demonstrated previously that the ain system activates luminescence gene expression at lower cell densities than those required for lux system activation and that both systems are essential for persistent colonization of the squid host, Euprymna scolopes.
  • Inactivation of ain, but not lux, quorum-sensing genes delayed initiation of the symbiotic relationship.
  • The V. fischeri luxI mutant does not express detectable light levels in symbiosis yet initiates colonization as well as the wild type, suggesting that ain quorum sensing regulates colonization factors other than luminescence.
  • We used a recently developed V. fischeri microarray to identify genes that are controlled by ain quorum sensing and could be responsible for the initiation defect.
  • Consistent with these data, ain quorum-sensing mutants displayed an altered motility behavior in vitro.
  • Taken together, these data suggest that the sequential activation of these two quorum-sensing systems with increasing cell density allows the specific regulation of early colonization factors (e.g., motility) by ain quorum sensing, whereas late colonization factors (e.g., luminescence) are preferentially regulated by lux quorum sensing.

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  • [CommentIn] J Bacteriol. 2005 Jun;187(11):3603-6 [15901681.001]
  • (PMID = 15901683.001).
  • [ISSN] 0021-9193
  • [Journal-full-title] Journal of bacteriology
  • [ISO-abbreviation] J. Bacteriol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / R01 RR012294; United States / NCRR NIH HHS / RR / RR12294
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Luminescent Proteins
  • [Other-IDs] NLM/ PMC1112064
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80. Siekas LL, Aboulafia DM: Establishing an anal dysplasia clinic for HIV-infected men: initial experience. AIDS Read; 2009 May;19(5):178-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Establishing an anal dysplasia clinic for HIV-infected men: initial experience.
  • Anal dysplasia caused by human papillomavirus (HPV) infection is common in the HIV-infected population and is a precursor to squamous cell carcinoma of the anus (SCCA).
  • Herein, we describe our initial experience in assessing the frequency and severity of anal intraepithelial neoplasia (AIN) in a newly formed anal dysplasia clinic in Seattle.
  • Forty-seven patients of the 122 patients who underwent biopsy (39%) had biopsy-identified low-grade AIN, and 47 (39%) had high-grade AIN (HGAIN).
  • Patient tolerance and acceptance of AIN screening was good, and the majority of those who underwent screening have been adherent to recommended follow-up examinations and treatment.
  • We anticipate that the anal dysplasia clinic will enable our institution to participate in emerging HIV- and HPV-related AIN clinical trials.
  • [MeSH-major] Anus Neoplasms / etiology. Carcinoma in Situ / etiology. Carcinoma, Squamous Cell / etiology. HIV Infections / epidemiology. Precancerous Conditions / etiology

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  • [CommentIn] AIDS Read. 2009 May;19(5):182-3 [19554737.001]
  • (PMID = 19554736.001).
  • [ISSN] 1053-0894
  • [Journal-full-title] The AIDS reader
  • [ISO-abbreviation] AIDS Read
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Kreuter A, Brockmeyer NH, Weissenborn SJ, Gambichler T, Stücker M, Altmeyer P, Pfister H, Wieland U, German Competence Network HIV/AIDS: Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia. J Invest Dermatol; 2008 Sep;128(9):2316-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia.
  • These patients have a strongly increased risk of HPV-induced anal cancer and its precursor lesion, anal intraepithelial neoplasia (AIN), and a moderately increased risk for penile cancer.
  • Only limited data exist on penile intraepithelial neoplasia (PIN) in HIV+MSM.
  • We determined the prevalence and evaluated the virologic characteristics of PIN and AIN in 263 HIV+MSM.
  • In case of histologically confirmed PIN (and AIN), HPV-typing, HPV-DNA load determination, and immunohistochemical staining for p16(INK4a) were performed.
  • PIN was detected in 11 (4.2%) and AIN in 156 (59.3%) patients.
  • Ten PIN patients also had AIN within the observation period.
  • Cutaneous beta-HPVs were found in PIN and AIN, but beta-HPV-DNA loads were very low, irrespective of the histological grade. p16(INK4a) Expression was detectable in all PIN lesions and correlated both with the histological grade and with high-risk HPV-DNA loads.
  • In view of the PIN prevalence found in our study, all HIV+MSM should be screened for PIN in addition to AIN screening.
  • [MeSH-major] Anus Diseases / epidemiology. Anus Neoplasms / epidemiology. Carcinoma in Situ / epidemiology. HIV Infections. Homosexuality, Male. Penile Neoplasms / epidemiology

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  • (PMID = 18385760.001).
  • [ISSN] 1523-1747
  • [Journal-full-title] The Journal of investigative dermatology
  • [ISO-abbreviation] J. Invest. Dermatol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00365729
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
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82. von Knebel Doeberitz M, Reuschenbach M: [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus]. Hautarzt; 2010 Jan;61(1):13-20
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  • [Title] [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus].
  • [Transliterated title] Humane Papillomviren in der Pathogenese der intraepithelialen Neoplasien (AIN) und Karzinome des Anus.
  • HPV infections have been implicated in the pathogenesis of anal cancers.
  • [MeSH-major] Anus Neoplasms / virology. Biomarkers, Tumor / analysis. Carcinoma in Situ / physiopathology. Papillomavirus Infections / diagnosis. Papillomavirus Infections / virology. Precancerous Conditions / virology

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  • (PMID = 20033115.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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83. Walts AE, Lechago J, Bose S: P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia. Am J Surg Pathol; 2006 Jul;30(7):795-801
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  • [Title] P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia.
  • HPV is also associated with anal squamous dysplasias and carcinomas.
  • Significant interobserver and intraobserver variation exists in the interpretation of biopsies for anal intraepithelial neoplasia (AIN).
  • This study was undertaken to assess the potential role of p16 and Ki67 immunohistochemical expression in refining the diagnosis and grading of AIN.One-hundred and four anal biopsies from 74 patients were retrieved from the surgical pathology files of the department.
  • After discrepancies were resolved and concurrence was achieved by at least 2 of 3 reviewing pathologists, the diagnoses were as follows: 37 negative, 12 condylomas without overt dysplasia, 14 AIN I, 25 AIN II, and 16 AIN III. p16 and Ki67 expression was evaluated by ABC immunoperoxidase staining whereas the presence of the high-risk subtypes of HPV virus was determined by in situ hybridization on a subset of the biopsies.
  • Nuclear and/or nuclear and cytoplasmic staining was considered as positive for p16 when present in >10% of squamous cells.
  • A band-like pattern of p16 immunoreactivity was seen in 21.4% AIN I, 80% AIN II, and 87.5% AIN III cases.
  • Spotty p16 immunoreactivity was observed in 8.1% negative, 8.3% condyloma, 14.3% AIN I, 12.0% AIN II, and 12.5% AIN III cases.
  • More than 50% of nuclei stained positive for Ki67 in 28.6% AIN I, 48.0% AIN II, and 75.0% AIN III cases but in none of the negative or condyloma cases.
  • On the basis of these results, a band-like pattern of p16 staining and Ki67 positivity in >50% of the squamous cell nuclei were strongly associated with high-grade AIN.
  • Most AIN I lesions stained similar to the nondysplastic cases.
  • A small subset of biopsies studied did not conform to the pattern described above: 4 of 14 (28.6%) AIN I lesions showed a band-like pattern of p16 staining and/or >50% Ki67 positive nuclei.
  • 4 of 25 (16.0%) AIN II lesions comprising 9.8% of the 41 high-grade AINs (AIN II and III) showed spotty p16 positivity and <50% Ki67 positive nuclei.
  • We conclude that when used together and evaluated in conjunction with H&E stained sections, p16 and Ki67 immunoexpression is a useful adjunct in the diagnosis and grading of AIN.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Ki-67 Antigen / metabolism. Papillomavirus Infections / pathology. Precancerous Conditions / pathology

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  • (PMID = 16819320.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / Ki-67 Antigen
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84. Capsoni F, Sarzi-Puttini P, Zanella A: Primary and secondary autoimmune neutropenia. Arthritis Res Ther; 2005;7(5):208-14
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  • In primary autoimmune neutropenia (AIN) of infancy, a moderate to severe neutropenia is the sole abnormality; it is rarely associated with serious infections and exhibits a self-limited course.
  • Secondary AIN is more commonly seen in adults and underlying causes include collagen disorders, drugs, viruses and lymphoproliferative disorders.
  • In most patients with AIN, antibodies recognize antigens located on the IgG Fc receptor type 3b but other target antigens have been recently identified in secondary AIN.
  • Granulocyte colony-stimulating factor is a proven treatment in patients with AIN of all types and is now preferred to other possible therapies.

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  • (PMID = 16207350.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Antineutrophil Cytoplasmic; 0 / Antigens, CD; 0 / Autoantigens; 0 / FCGR3B protein, human; 0 / GPI-Linked Proteins; 0 / Immunoglobulins, Intravenous; 0 / Isoantigens; 0 / Receptors, IgG; 0 / neutrophil-specific antigen NA1, human; 143011-72-7 / Granulocyte Colony-Stimulating Factor
  • [Number-of-references] 67
  • [Other-IDs] NLM/ PMC1257445
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85. Al Hwiesh A: Aggrenox-associated acute interstitial nephritis. Saudi J Kidney Dis Transpl; 2006 Mar;17(1):50-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Acute interstitial nephritis (AIN) associated with the administration of the combination drug Aggrenox ( acetylsalicylic acid 25 mg and dipyridamole 200 mg) has not been previously reported.
  • The renal biopsy showed acute interstitial nephritis (AIN).
  • The serologic investigations for common infectious and immune causes of AIN were negative.
  • In conclusion, this patient suffered AIN associated with the administration of Aggrenox and improved with discontinuation of this drug.
  • Further investigation may be needed to evaluate the prevalence of AIN associated with Aggrenox.

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  • (PMID = 17297537.001).
  • [ISSN] 1319-2442
  • [Journal-full-title] Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • [ISO-abbreviation] Saudi J Kidney Dis Transpl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Aspirin, Dipyridamole Drug Combination
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86. Parkhie SM, Fine DM, Lucas GM, Atta MG: Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis. Clin J Am Soc Nephrol; 2010 May;5(5):798-804
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND OBJECTIVES: The objective of this study was to describe the characteristics of patients with HIV infection and biopsy-proven acute interstitial nephritis (AIN).
  • Patients who received a diagnosis of AIN without evidence of HIV-associated nephropathy were identified, and their clinical course was reviewed up to 18 months after biopsy.
  • RESULTS: Of 262 biopsies, 29 (11%) patients who had AIN without evidence of HIV-associated nephropathy were identified.
  • Drugs were identified as the cause of AIN in the majority (72%) of cases.
  • CONCLUSIONS: In our series, AIN was prevalent (11%) and was often drug induced.
  • AIN should not be excluded from the differential diagnosis on the basis of absence of the classic clinical triad of fever, rash, and pyuria.

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  • (PMID = 20338962.001).
  • [ISSN] 1555-905X
  • [Journal-full-title] Clinical journal of the American Society of Nephrology : CJASN
  • [ISO-abbreviation] Clin J Am Soc Nephrol
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / K23 DA015616; United States / NIDA NIH HHS / DA / R01 DA018577; United States / NIDA NIH HHS / DA / R01 DA026770
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
  • [Other-IDs] NLM/ PMC2863972
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87. Appel GB: The treatment of acute interstitial nephritis: More data at last. Kidney Int; 2008 Apr;73(8):905-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Acute interstitial nephritis (AIN) is an uncommon form of acute renal failure that is usually medication related.
  • The study by González et al., although it has limitations, provides solid support for the early use of corticosteroids in the treatment of drug-related AIN.

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  • [CommentOn] Kidney Int. 2008 Apr;73(8):940-6 [18185501.001]
  • (PMID = 18379525.001).
  • [ISSN] 1523-1755
  • [Journal-full-title] Kidney international
  • [ISO-abbreviation] Kidney Int.
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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88. Grases F, Sanchis P, Perello J, Isern B, Prieto RM, Fernandez-Palomeque C, Saus C: Phytate reduces age-related cardiovascular calcification. Front Biosci; 2008;13:7115-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The AIN group was fed a purified diet (AIN-76A) with an undetectable level of phytate.
  • The PHY group was fed with a purified diet (AIN-76A) enriched with phytate (phytin, as the calcium magnesium salt).
  • The MOD group was fed with the AIN-76A diet (phytate undetectable) enriched with MgO, inositol and CaHPO4.
  • Phytate-treated rats (the control and PHY groups) had significantly lower levels of calcium in the aorta compared to nonphytate-treated rats (AIN and MOD groups).

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  • (PMID = 18508720.001).
  • [ISSN] 1093-9946
  • [Journal-full-title] Frontiers in bioscience : a journal and virtual library
  • [ISO-abbreviation] Front. Biosci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 7IGF0S7R8I / Phytic Acid
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89. Lin CY, Tsai ZY, Cheng IC, Lin SH: Effects of fermented soy milk on the liver lipids under oxidative stress. World J Gastroenterol; 2005 Dec 14;11(46):7355-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Forty-five healthy male Sprague-Dawley rats were randomly assigned to five groups according to five different diets: control (AIN-76), AIN-76+high-dose fermented soy milk powder, AIN-76+low-dose fermented soy milk powder, AIN-76+high-dose milk yogurt powder and AIN-76+low-dose milk yogurt powder.

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  • (PMID = 16437642.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Powders; 0 / Thiobarbituric Acid Reactive Substances; CL2T97X0V0 / Carbon Tetrachloride; EC 3.1.3.1 / Alkaline Phosphatase
  • [Other-IDs] NLM/ PMC4725133
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90. Gagne SE, Jensen R, Polvi A, Da Costa M, Ginzinger D, Efird JT, Holly EA, Darragh T, Palefsky JM: High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia. J Acquir Immune Defic Syndr; 2005 Oct 1;40(2):182-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia.
  • Anal intraepithelial neoplasia (AIN) is the likely precursor to anal cancer.
  • AIN is associated with human papillomavirus (HPV) infection, and HPV-associated genomic instability may play an important role in the progression of squamous intraepithelial neoplasia to cancer.
  • Microarray-based comparative genome hybridization (aCGH) was performed on DNA from AIN specimens to determine the host genomic alterations and their correlation with HPV DNA integration or rearrangement.
  • Of 27 high-grade AIN specimens tested by CGH, 8 (30%) showed regional DNA copy number abnormalities (CNAs).
  • Our data suggest that there may be several oncogenes in this region that are coactivated to contribute to progression to high-grade AIN.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Genome, Viral. Papillomaviridae / physiology. Virus Integration

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  • (PMID = 16186736.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / R01CA54053; United States / NCI NIH HHS / CA / U01 CA66529; United States / NCI NIH HHS / CA / U01 CA70019
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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91. Peres M, Neves AJ, Monteiro T, Magalhães S, Franco N, Lorenz K, Alves E, Damilano B, Massies J, Dussaigne A, Grandjean N: Optical and structural properties of an Eu implanted gallium nitride quantum dots/aluminium nitride superlattice. J Nanosci Nanotechnol; 2010 Apr;10(4):2473-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • GaN/AIN structures made of GaN quantum dots (QDs) separated by AIN spacer layers, were doped with Europium by ion implantation.
  • From its behaviour under different photon energy excitation and sample temperature we concluded that the Eu-related emitting centres are located inside the GaN QDs or dispersed in the GaN and AIN buffer or spacer layers.

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  • (PMID = 20355450.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Kreuter A, Jesse M, Potthoff A, Brockmeyer NH, Gambichler T, Stücker M, Bechara FG, Pfister H, Wieland U: Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men. J Am Acad Dermatol; 2010 Sep;63(3):490-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men.
  • BACKGROUND: Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)-associated precursor lesion of anal carcinoma, is highly prevalent among HIV-infected individuals, especially in men having sex with men (MSM).
  • Early diagnosis and treatment of AIN might prevent development of anal cancer.
  • OBJECTIVES: We aimed to evaluate the expression of 8 promising proliferative biomarkers in anal dysplasia and to compare the efficacy of these markers in diagnosing high-grade AIN.
  • METHODS: Immunohistochemical analysis of minichromosome maintenance proteins (MCM3, MCM4, MCM6, and MCM7), p21, Ki-67, p16, and proliferating cell nuclear antigen (PCNA) was performed in a total of 49 specimens of normal anal mucosa and high- and low-grade anal dysplasia.
  • In the progression from normal epithelium to high-grade dysplasia, we found significant differences in the expression of all biomarkers.
  • A cutoff of 25% or 50% lesional immunopositivity for the 4 MCMs, Ki-67, and p16 resulted in 100% sensitivity and 100% specificity to diagnose high-grade AIN.
  • Sensitivity and specificity of PCNA and p21 for a high-grade AIN diagnosis were lower.
  • HPV-DNA was detectable in 100% of high-grade AIN and 87.5% of low-grade AIN lesions.
  • CONCLUSIONS: MCMs, Ki67, and p16 are reliable immunohistochemical adjuncts for diagnosing high-grade AIN.
  • [MeSH-major] Anus Neoplasms / pathology. Biomarkers, Tumor / analysis. Carcinoma in Situ / pathology. HIV Infections / diagnosis. Proliferating Cell Nuclear Antigen / metabolism
  • [MeSH-minor] Adult. Aged. Analysis of Variance. Antiretroviral Therapy, Highly Active / methods. Biopsy, Needle. DNA, Viral / analysis. HIV Seropositivity. Homosexuality, Male. Humans. Immunohistochemistry. Intestinal Mucosa / metabolism. Intestinal Mucosa / pathology. Male. Middle Aged. Neoplasm Staging. Papillomavirus Infections / complications. Papillomavirus Infections / diagnosis. Polymerase Chain Reaction / methods. Precancerous Conditions / pathology. Reference Values. Risk Assessment. Sensitivity and Specificity. Viral Load. Young Adult

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  • [Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20006407.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Viral; 0 / Proliferating Cell Nuclear Antigen
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93. Ochi K, Horiuchi Y, Tazaki K, Nishi K, Kawashima H, Yabe H: Spontaneous anterior interosseous nerve palsy with Churg-Strauss syndrome. Mod Rheumatol; 2010 Oct;20(5):514-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Electromyography demonstrated isolated anterior interosseous nerve (AIN) palsy, with no other peripheral neuropathy.
  • We diagnosed this case as spontaneous AIN palsy complicated with CSS, the first case of this kind.

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  • (PMID = 20458608.001).
  • [ISSN] 1439-7609
  • [Journal-full-title] Modern rheumatology
  • [ISO-abbreviation] Mod Rheumatol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glucocorticoids; VB0R961HZT / Prednisone; X4W7ZR7023 / Methylprednisolone
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94. Radwan M, Bahgat M: Novel growth of aluminium nitride nanowires. J Nanosci Nanotechnol; 2006 Feb;6(2):558-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • This work describes novel growth of aluminium nitride (AIN) nanowires by nitridation of a mixture consists of aluminium and ammonium chloride powders (Al:NH4Cl = 1.5:1 weight ratio) at 1000 degrees C for 1 h in flowing nitrogen gas (1 l/min).
  • XRD analysis of the product showed the formation of pure hexagonal AIN.
  • SEM micrographs of as-synthesized product revealed the growth of homogeneous AIN nanowires (phi 40-150 nm).

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  • (PMID = 16573061.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aluminum Compounds; 7K47D7P3M0 / aluminum nitride
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95. Okabe T, Toda T, Nukitrangsan N, Inafuku M, Iwasaki H, Yanagita T, Oku H: Comparative study of the effect of basal diet formulation, dietary fat and cholesterol levels on the development of aortic atherosclerotic lesions in B6.KOR-Apoeshl mice. J Oleo Sci; 2010;59(4):161-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To optimize the adequate atherogenic diet composition for nutritional atherosclerosis studies utilizing B6.KOR-Apoe(shl) mice, we investigated the effect of dietary cholesterol, AIN formula, and dietary fats on the development of atherosclerosis.
  • Furthermore, there were no significant differences in the degree of atherosclerosis between B6.KOR-Apoe(shl) mice fed a modified-AIN-76 diet and those fed a modified-AIN-93M diet containing corn oil or soybean oil for 10 and 12 weeks.

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  • (PMID = 20299762.001).
  • [ISSN] 1347-3352
  • [Journal-full-title] Journal of oleo science
  • [ISO-abbreviation] J Oleo Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cholesterol, Dietary; 0 / Dietary Fats; 0 / Lipids
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96. Hanawa N, Tanaka A, Fukami M, Miura R, Goto H, Tashiro H, Aiso M, Takamori Y, Fujita Y, Sato T, Kawaguchi H, Kobayashi M, Takikawa H: Autoimmune neutropenia due to antineutrophil antibodies in a patient with primary sclerosing cholangitis. Clin J Gastroenterol; 2010 Jun;3(3):149-54

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Autoimmune neutropenia (AIN) is defined as a decrease in the circulating absolute neutrophil count (ANC) to less than 1500/μl caused by serum antineutrophil antibodies.
  • Secondary AIN is associated with various autoimmune diseases.
  • Herein we present the case of a patient with primary sclerosing cholangitis (PSC) who developed secondary AIN.
  • A 19-year-old man was admitted due to liver injury, and a diagnosis of PSC was established by cholangiogram and liver biopsy.
  • Therefore we suspected secondary AIN as a causative etiology and examined whether antineutrophil antibodies were detectable in the patient's sera by flow cytometric analysis of the granulocyte indirect immunofluorescence test.
  • This is the first reported case of a patient with PSC who developed AIN, with detection of serum antineutrophil antibodies.

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  • (PMID = 26190122.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Autoimmune disease / Cholestasis / Granulocyte indirect immunofluorescence test / Neutropenia
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97. Salit IE, Lytwyn A, Raboud J, Sano M, Chong S, Diong C, Chapman W, Mahony JB, Tinmouth J: The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening. AIDS; 2010 Jun 1;24(9):1307-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening.
  • OBJECTIVE: To assess anal oncogenic human papillomavirus (HPV) and anal cytology as screening tests for detecting high-grade anal intraepithelial neoplasia (AIN 2+), as this is an immediate anal cancer precursor.
  • The endpoint was histologically confirmed AIN 2+ obtained by high-resolution anoscopy.
  • METHODS: We did concomitant anal cytology, anal HPV testing and HRA with directed biopsies without knowing the results of each intervention.
  • The main outcome measures were the sensitivity, specificity, negative predictive value and positive predictive value of anal cytology and oncogenic HPV for the detection of AIN 2+.
  • RESULTS: Cytology was abnormal in 67% of patients: high-grade squamous intraepithelial lesion, 12%; low-grade squamous intraepithelial lesion, 43% and atypical squamous cells of undetermined significance, 12%.
  • Biopsies were abnormal in 68% of patients: AIN 2+, 25% and AIN 1, 43%.
  • Test performance characteristics for the detection of AIN 2+ using any abnormality on anal cytology were: sensitivity 84%, specificity 39%, negative predictive value 88% and positive predictive value 31%; using oncogenic HPV: sensitivity 100%, specificity 16%, negative predictive value 100% and positive predictive value 28%.
  • CONCLUSION: Anal cytology and HPV detection have high sensitivity but low specificity for detecting AIN 2+.
  • HIV-positive men who have sex with men have a high prevalence of AIN 2+ and require high-resolution anoscopy for optimal detection of high-grade anal dysplasia.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Cytodiagnosis / methods. Papillomavirus Infections / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Anal Canal / cytology. Anal Canal / pathology. Biopsy. Cross-Sectional Studies. Early Detection of Cancer. Homosexuality, Male. Humans. Male. Middle Aged. Sensitivity and Specificity. Sexual Behavior. Specimen Handling

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  • (PMID = 20442633.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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98. Vucic S, Yiannikas C: Anterior interosseous nerve conduction study: normative data. Muscle Nerve; 2007 Jan;35(1):119-21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurophysiological techniques assessing anterior interosseous nerve (AIN) function and employing surface electrode recordings from the flexor pollicis longus (FPL), have been limited by technical difficulties.
  • The aim of this study was to describe a surface electrode recording technique of investigating the AIN by recording compound muscle action potentials (CMAPs) from FPL.
  • [MeSH-minor] Action Potentials / physiology. Adult. Aged. Electrodes / standards. Electromyography / instrumentation. Electromyography / methods. Female. Humans. Male. Median Neuropathy / complications. Median Neuropathy / diagnosis. Middle Aged. Paresis / diagnosis. Paresis / etiology. Predictive Value of Tests. Reference Values. Retrospective Studies

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  • (PMID = 16967471.001).
  • [ISSN] 0148-639X
  • [Journal-full-title] Muscle & nerve
  • [ISO-abbreviation] Muscle Nerve
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Wu K, Han T, Shen K, Li B, Peng T, Pan Y, Sun H, Liu C: Growth of vertically aligned InGaN nanorod arrays on p-type Si substrates for heterojunction diodes. J Nanosci Nanotechnol; 2010 Dec;10(12):8139-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • InGaN nanorod arrays have been grown by molecular beam epitaxy on bare and high-temperature AIN-buffered Si(111) substrates.
  • It has been found that well vertically aligned InGaN nanorod arrays can be grown by using the high-temperature AIN buffer layer.
  • By using the high-temperature AIN buffer layer, the interface quality was improved, and uniform InGaN nanorods could be grown.

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  • (PMID = 21121307.001).
  • [ISSN] 1533-4880
  • [Journal-full-title] Journal of nanoscience and nanotechnology
  • [ISO-abbreviation] J Nanosci Nanotechnol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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100. Bean SM, Meara RS, Vollmer RT, Conner MG, Crowe DR, Novak L, Eltoum IA, Robboy SJ, Chhieng DC: p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia. J Low Genit Tract Dis; 2009 Jul;13(3):145-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.
  • OBJECTIVES: Evaluation of anal intraepithelial neoplasia (AIN) is subjective.
  • Previous studies have shown p16 and Ki-67 expressions to correlate with AIN grade.
  • The objectives were (1) to determine the extent of interobserver agreement in evaluating AIN on routine hematoxylin and eosin (H&E) sections and (2) to test whether p16 and/or Ki-67 staining improve interobserver diagnostic agreement.
  • MATERIALS AND METHODS: Seventy-seven anal specimens were retrieved.
  • Diagnoses were normal/reactive, AIN I/HPV, AIN II, and AIN III.
  • Fair agreement was observed using H&E diagnosis alone (kappa = 0.38, S = 0.56).
  • CONCLUSIONS: Interobserver agreement for diagnosis of AIN was fair when based solely on H&E preparation. p16 alone improved interobserver agreement and demonstrated superior agreement when compared with H&E, Ki-67, and H&E/p16/Ki-67 combined.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma in Situ / diagnosis. DNA, Neoplasm / analysis. Gene Expression Regulation, Neoplastic. Genes, p16 / physiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / analysis. Biopsy. Clinical Competence. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Observer Variation. Retrospective Studies

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  • (PMID = 19550211.001).
  • [ISSN] 1526-0976
  • [Journal-full-title] Journal of lower genital tract disease
  • [ISO-abbreviation] J Low Genit Tract Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / DNA, Neoplasm
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