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1. Sahoo S: HIV- and AIDS-related Ocular Manifestations in Tanzanian Patients. Malays J Med Sci; 2010 Jan;17(1):12-6
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  • [Title] HIV- and AIDS-related Ocular Manifestations in Tanzanian Patients.
  • The objective of this study was to describe the ocular manifestations of HIV and AIDS-related patients who had been admitted to TM Jafferji Hospital, Dar-es-Salaam, Tanzania.
  • The notable ocular manifestations included micro-vasculopathy of the retina in 25%, uveitis in 8%, CMV retinitis in 7%, neuro-ophthalmic manifestation in 6%, Herpes zoster ophthalmicus in 5%, Kaposi's sarcoma in 3% and conjunctival carcinoma in 2% of cases.

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  • (PMID = 22135520.001).
  • [ISSN] 2180-4303
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3216149
  • [Keywords] NOTNLM ; AIDS / CMV retinitis / HIV / medical sciences / micro-vasculopathy
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2. Sasco AJ, Jaquet A, Boidin E, Ekouevi DK, Thouillot F, Lemabec T, Forstin MA, Renaudier P, N'dom P, Malvy D, Dabis F: The challenge of AIDS-related malignancies in sub-Saharan Africa. PLoS One; 2010;5(1):e8621
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  • [Title] The challenge of AIDS-related malignancies in sub-Saharan Africa.
  • BACKGROUND: With the lengthening of life expectancy among HIV-positive subjects related to the use of highly active antiretroviral treatments, an increased risk of cancer has been described in industrialized countries.
  • METHODS AND FINDINGS: Studies for this review were identified from several bibliographical databases including Pubmed, Scopus, Cochrane, Pascal, Web of Science and using keywords "HIV, neoplasia, epidemiology and Africa" and related MesH terms.
  • A clear association was found between HIV infection and AIDS-classifying cancers.
  • For non AIDS-classifying cancers, squamous cell conjunctival carcinoma of the eye was associated with HIV in many case-referent studies with ORs from 2.6 (1.4-4.9) to 13.0 (4.5-39.4).
  • CONCLUSION: Studies conducted in sub-Saharan Africa show that HIV infection is not only strongly associated with AIDS-classifying cancers but also provided some evidence of association for other neoplasia.
  • African countries need now to implement well designed population-based studies in order to better describe the spectrum of AIDS-associated malignancies and the most effective strategies for their prevention, screening and treatment.

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  • (PMID = 20066157.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / U01 AI069919
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2799672
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3. De Giorgi V, Monaco A, Worchech A, Tornesello M, Izzo F, Buonaguro L, Marincola FM, Wang E, Buonaguro FM: Gene profiling, biomarkers and pathways characterizing HCV-related hepatocellular carcinoma. J Transl Med; 2009;7:85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene profiling, biomarkers and pathways characterizing HCV-related hepatocellular carcinoma.
  • BACKGROUND: Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) worldwide.
  • Samples were obtained from 14 patients affected by HCV-related HCC and 7 HCV-negative non-liver-cancer patients, enrolled at INT in Naples.
  • RESULTS: Significant differences were found between the expression patterns of several genes falling into different metabolic and inflammation/immunity pathways in HCV-related HCC tissues as well as the non-HCC counterpart compared to normal liver tissues.
  • Only few genes were found differentially expressed between HCV-related HCC tissues and paired non-HCC counterpart.
  • CONCLUSION: In this study, informative data on the global gene expression pattern of HCV-related HCC and non-HCC counterpart, as well as on their difference with the one observed in normal liver tissues have been obtained.
  • These results may lead to the identification of specific biomarkers relevant to develop tools for detection, diagnosis, and classification of HCV-related HCC.
  • [MeSH-major] Biomarkers. Carcinoma, Hepatocellular. Gene Expression Profiling. Hepacivirus / genetics. Hepatitis C / genetics. Liver Neoplasms

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  • (PMID = 19821982.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers
  • [Other-IDs] NLM/ PMC2768694
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4. Bibas M, Antinori A: EBV and HIV-Related Lymphoma. Mediterr J Hematol Infect Dis; 2009;1(2):e2009032

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] EBV and HIV-Related Lymphoma.
  • It has been largely implicated in the development of B-cell lymphoproliferative disorders as Burkitt lymphoma (BL), Hodgkin disease (HD), systemic non Hodgkin lymphoma (NHL), primary central nervous system lymphoma (PCNSL), nasopharyngeal carcinoma (NC).
  • Virus-associated lymphomas are becoming of significant concern for the mortality of long-lived HIV immunocompromised patients, and therefore, research of advanced strategies for AIDS-related lymphomas is an important field in cancer chemotherapy.
  • Detailed understanding of the EBV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy The linkage of HIV-related lymphoma with EBV infection of the tumor clone has several pathogenetic, prognostic and possibly therapeutic implications which are reviewed herein.

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  • (PMID = 21416008.001).
  • [ISSN] 2035-3006
  • [Journal-full-title] Mediterranean journal of hematology and infectious diseases
  • [ISO-abbreviation] Mediterr J Hematol Infect Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3033170
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5. Lanoy E, Dores GM, Madeleine MM, Toro JR, Fraumeni JF Jr, Engels EA: Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS; 2009 Jan 28;23(3):385-93
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States.
  • We evaluated skin cancer epidemiology among persons with AIDS.
  • DESIGN: We linked data from population-based US AIDS and cancer registries to evaluate risk of nonkeratinocytic skin cancers (melanoma, Merkel cell carcinoma, and appendageal carcinomas, including sebaceous carcinoma) in 497 142 persons with AIDS.
  • RESULTS: From 60 months before to 60 months after AIDS onset, persons with AIDS had elevated risks of melanoma (SIR = 1.3, 95% confidence interval 1.1-1.4, n = 292 cases) and, more strongly, of Merkel cell carcinoma (SIR = 11, 95% confidence interval 6.3-17, n = 17) and sebaceous carcinoma (SIR = 8.1, 95% confidence interval 3.2-17, n = 7).
  • Risk for appendageal carcinomas increased with progressive time relative to AIDS onset (P trend = 0.03).
  • Melanoma risk was unrelated to CD4 cell count at AIDS onset (P = 0.32).
  • CONCLUSION: Among persons with AIDS, there is a modest excess risk of melanoma, which is not strongly related to immunosuppression and may relate to ultraviolet radiation exposure.
  • In contrast, the greatly increased risks for Merkel cell and sebaceous carcinoma suggest an etiologic role for immunosuppression.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / immunology. Adenocarcinoma, Sebaceous / virology. Adolescent. Adult. CD4 Lymphocyte Count. Carcinoma, Merkel Cell / epidemiology. Carcinoma, Merkel Cell / immunology. Carcinoma, Merkel Cell / virology. Child. Child, Preschool. Epidemiologic Methods. Female. Humans. Immunocompromised Host. Infant. Infant, Newborn. Male. Melanoma / epidemiology. Melanoma / immunology. Melanoma / virology. Middle Aged. United States / epidemiology. Young Adult

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  • (PMID = 19114864.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010150-08
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS89955; NLM/ PMC2728602
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6. Roman S, Panduro A, Aguilar-Gutierrez Y, Maldonado M, Vazquez-Vandyck M, Martinez-Lopez E, Ruiz-Madrigal B, Hernandez-Nazara Z: A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review. Hepatol Int; 2009 Jun;3(2):343-55

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A low steady HBsAg seroprevalence is associated with a low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma in Mexico: a systematic review.
  • To address the relationship between hepatitis B virus (HBV) endemicity and HBV-related liver diseases in Mexico.
  • A low HBsAg prevalence is related to the low incidence of HBV-related liver cirrhosis and hepatocellular carcinoma (HCC) previously reported in Mexico.

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  • (PMID = 19669360.001).
  • [ISSN] 1936-0533
  • [Journal-full-title] Hepatology international
  • [ISO-abbreviation] Hepatol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2716764
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7. Akanmu AS: AIDS-associated malignancies. Afr J Med Med Sci; 2006 Dec;35 Suppl:57-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] AIDS-associated malignancies.
  • Three neoplastic diseases are associated so commonly with HIV infection that each of them has become recognized as an AIDS defining illness.
  • These are Kaposi's Sarcoma (KS), Non-Hodgkin's Lymphoma (NHL) and Cervical Carcinoma.
  • Both KS and NHL were recognized as AIDS associated cancers from the onset of the epidemic in 1981 but carcinoma of the cervix became AIDS defining in 1993.
  • [MeSH-major] HIV. Lymphoma, AIDS-Related / epidemiology. Lymphoma, Non-Hodgkin / epidemiology. Sarcoma, Kaposi / epidemiology

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  • (PMID = 18050776.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Nigeria
  • [Number-of-references] 114
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8. Aisenberg G, Marcos LA, Ogbaa I: Recurrent histoplasmosis in AIDS mimicking a colonic carcinoma. Int J STD AIDS; 2009 Jun;20(6):429-30
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  • [Title] Recurrent histoplasmosis in AIDS mimicking a colonic carcinoma.
  • The prevalence rate of lower gastrointestinal bleeding in patients with AIDS is around 2.6%.
  • A 42-year-old woman with AIDS (CD(4) count 9/microL) and recently treated for disseminated histoplasmosis presented to the emergency room with melena, severe anaemia and fever.
  • A colonoscopy showed an umbilicated colonic nodule mimicking a carcinoma of the colon.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. Carcinoma / diagnosis. Colonic Neoplasms / diagnosis. Gastrointestinal Hemorrhage / etiology. HIV Infections / complications. Histoplasmosis / diagnosis


9. Peer FI, Pui MH, Rae WI, Mosam A: 99mTc-MIBI imaging of AIDS-related Kaposi's sarcoma in the lungs. Nucl Med Commun; 2008 Sep;29(9):786-90
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • [Title] 99mTc-MIBI imaging of AIDS-related Kaposi's sarcoma in the lungs.
  • OBJECTIVE: Pulmonary Kaposi's sarcoma (KS) occurs in more than 10% of patients with acquired immunodeficiency syndrome (AIDS) and has a high mortality rate.
  • The objective of this study was to determine the efficacy of 99mTc-hexakis-2-methoxy isobutyl isonitrile (99mTc-MIBI) imaging in detecting pulmonary AIDS-related KS.
  • METHODS: 99mTc-MIBI imaging was performed on 72 human immunodeficiency virus-seropositive patients with bronchoscopic diagnosis of pulmonary KS (36 patients), pneumonia (22), normal tracheo-bronchial tree (11), lymphoma (2), and bronchogenic carcinoma (1).


10. Orem J, Otieno MW, Remick SC: Challenges and opportunities for treatment and research of AIDS-related malignancies in Africa. Curr Opin Oncol; 2006 Sep;18(5):479-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Challenges and opportunities for treatment and research of AIDS-related malignancies in Africa.
  • PURPOSE OF REVIEW: Following our review of AIDS-associated cancer in developing nations in 2004, we sought to update recent publications and review data on the challenges and opportunities for the treatment and research of AIDS malignancies in Africa.
  • RECENT FINDINGS: It is apparent that the burden of AIDS-related malignancies and other virus-associated tumors is significant and increasing in Africa.
  • Several recent studies report findings on conjunctival squamous cell carcinoma and there is a report that Hodgkin's disease, a non-AIDS-defining neoplasm, is increasing in incidence.
  • International collaborative partnerships dedicated to AIDS malignancies in developing countries are feasible and invaluable for clinical strategies to address this aspect of the pandemic.
  • A departure point is the ongoing work of the East Africa - Case Western Reserve University Collaboration in AIDS malignancies.

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  • (PMID = 16894296.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI36219; United States / NCI NIH HHS / CA / CA43703; United States / NCI NIH HHS / CA / CA70081; United States / NCI NIH HHS / CA / CA83528; United States / FIC NIH HHS / TW / TW00011
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Number-of-references] 56
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11. Clifford GM, Rickenbach M, Polesel J, Dal Maso L, Steffen I, Ledergerber B, Rauch A, Probst-Hensch NM, Bouchardy C, Levi F, Franceschi S, Swiss HIV Cohort: Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma. AIDS; 2008 Oct 18;22(16):2135-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma.
  • OBJECTIVE: To investigate HIV-related immunodeficiency as a risk factor for hepatocellular carcinoma (HCC) among persons infected with HIV, while controlling for the effect of frequent coinfection with hepatitis C and B viruses.
  • CONCLUSION: Lower CD4+ cell counts increased the risk for HCC among persons infected with HIV, an effect that was particularly evident for hepatitis B virus-related HCC arising in non-injecting drug users.
  • [MeSH-major] Carcinoma, Hepatocellular / virology. HIV Infections / complications. Liver Neoplasms / virology

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  • (PMID = 18832877.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / Hepatitis B Surface Antigens
  • [Investigator] Battegay M; Bernasconi E; Böni J; Bucher HC; Bürgisser P; Calmy A; Cattacin S; Cavassini M; Dubs R; Egger M; Elzi L; Fischer M; Flepp M; Fontana A; Francioli P; Furrer H; Fux C; Gorgievski M; Günthard H; Hirsch H; Hirschel B; Hösli I; Kahlert Ch; Kaiser L; Karrer U; Kind C; Klimkait T; Ledergerber B; Martinetti G; Martinez B; Müller N; Nadal D; Opravil M; Paccaud F; Pantaleo G; Rauch A; Regenass S; Rickenbach M; Rudin C; Schmid P; Schultze D; Schüpbach J; Speck R; Taffé P; Telenti A; Trkola A; Vernazza P; Weber R; Yerly S
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12. Lim ST, Levine AM: Non-AIDS-defining cancers and HIV infection. Curr HIV/AIDS Rep; 2005 Aug;2(3):146-53
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  • [Title] Non-AIDS-defining cancers and HIV infection.
  • With fewer patients now succumbing to infectious complications of AIDS, other HIV-related morbidities, such as malignancies, have become increasingly important.
  • Apart from Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer, which are considered as AIDS-defining, several additional cancers, referred to as non-AIDS-defining cancers, are also statistically increased in HIV-infected persons.
  • These include Hodgkin's disease, anal carcinoma, lung cancer, nonmelanomatous skin cancer, and testicular germ cell tumors, among others.
  • Although immunosuppression is consistently associated with an increased risk of AIDS-related malignancies, the role of immunosuppression in the pathogenesis of non-AIDS- defining cancers is controversial.

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  • (PMID = 16091262.001).
  • [ISSN] 1548-3568
  • [Journal-full-title] Current HIV/AIDS reports
  • [ISO-abbreviation] Curr HIV/AIDS Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 64
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13. Heyns CF, Groeneveld AE, Sigarroa NB: Urologic complications of HIV and AIDS. Nat Clin Pract Urol; 2009 Jan;6(1):32-43
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  • [Title] Urologic complications of HIV and AIDS.
  • Disease progression from HIV to AIDS and HIV-related mortality can be reduced effectively by several years of treatment with highly active antiretroviral therapy (HAART).
  • For patients who do not have access to HAART, HIV infection continues to be a lethal disorder characterized by opportunistic infection with uncommon organisms (e.g. mycobacteria, fungi, parasites and viruses), as well as lethal malignancies such as Kaposi sarcoma, non-Hodgkin lymphoma and squamous cell carcinoma of the penis or cervix.

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  • [ErratumIn] Nat Clin Pract Urol. 2010 Apr;7(4):178
  • (PMID = 19132004.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 134
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14. Panther LA, Schlecht HP, Dezube BJ: Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients. AIDS Read; 2005 Feb;15(2):79-82, 85-6, 88, 91
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  • [Title] Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients.
  • The incidence of human papillomavirus (HPV)-related anal squamous cell carcinoma is increasing.
  • It is likely that long-standing HIV-related immunosuppression plays a significant role in the pathogenesis of anal carcinoma; however, a direct HIV-HPV interaction has also been implicated.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. HIV Infections / epidemiology. Papillomaviridae / isolation & purification. Papillomavirus Infections / epidemiology. Precancerous Conditions / pathology


15. Shiboski CH, Patton LL, Webster-Cyriaque JY, Greenspan D, Traboulsi RS, Ghannoum M, Jurevic R, Phelan JA, Reznik D, Greenspan JS, Oral HIV/AIDS Research Alliance, Subcommittee of the AIDS Clinical Trial Group: The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints. J Oral Pathol Med; 2009 Jul;38(6):481-8
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  • [Title] The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints.
  • The Oral HIV/AIDS Research Alliance (OHARA) is part of the AIDS Clinical Trials Group (ACTG), the largest HIV clinical trials organization in the world.
  • Its main objective is to investigate oral complications associated with HIV/AIDS as the epidemic is evolving, in particular, the effects of antiretrovirals on oral mucosal lesion development and associated fungal and viral pathogens.
  • Many studies have shared end-points, which include oral diseases known to be associated with HIV/AIDS measured by trained and calibrated ACTG study nurses.
  • The objective of this article is to present updated case definitions for HIV-related oral diseases that will be used to measure standardized clinical end-points in OHARA studies, and that can be used by any investigator outside of OHARA/ACTG conducting clinical research that pertains to these end-points.

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  • (PMID = 19594839.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / U01 AI068636; United States / NIAID NIH HHS / AI / U01 AI 68636
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
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16. Diamond C, Taylor TH, Aboumrad T, Bringman D, Anton-Culver H: Increased incidence of squamous cell anal cancer among men with AIDS in the era of highly active antiretroviral therapy. Sex Transm Dis; 2005 May;32(5):314-20
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  • [Title] Increased incidence of squamous cell anal cancer among men with AIDS in the era of highly active antiretroviral therapy.
  • OBJECTIVE: We sought to determine if the introduction of highly active antiretroviral therapy (HAART) corresponded with changes in anal squamous cell cancer rates among men with AIDS.
  • STUDY: We linked cancer registry data from 1988-2000 and AIDS registry data from 1981-July/2003 for San Diego County.
  • RESULTS: The annual incidence of invasive anal cancer increased from zero per 100,000 men with AIDS aged 25 to 64 years (95% confidence interval [CI], 0-226) in 1991 to 224 per 100,000 (95% CI, 102-425) in the year 2000.
  • Pre-HAART, the average annual incidence of invasive anal cancer was 49 per 100,000 men with AIDS aged 25 to 64 years (95% CI, 16-114) versus 144 per 100,000 (95% CI, 93-212) post-HAART.
  • The relative risk of invasive anal cancer among men with AIDS compared with men without known HIV/AIDS was 98 (95% CI, 36-264) pre-HAART and 352 (95% CI, 186-669) post-HAART.
  • The increased incidence of anal cancer among men with AIDS resulted in an increase in the overall rate of anal cancer among men in San Diego County.
  • CONCLUSIONS: The rising incidence of anal cancer among men with AIDS may be related to increased longevity with HAART and the consequent increased time at risk for the development of malignancy and/or the result of greater use of cytologic screening.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / complications. Anus Neoplasms / epidemiology. Carcinoma, Squamous Cell / epidemiology

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  • (PMID = 15849533.001).
  • [ISSN] 0148-5717
  • [Journal-full-title] Sexually transmitted diseases
  • [ISO-abbreviation] Sex Transm Dis
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1K07CA096480-1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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17. Mani D, Guinee DG Jr, Aboulafia DM: AIDS-associated plasmablastic lymphoma presenting as a poorly differentiated esophageal tumor: a diagnostic dilemma. World J Gastroenterol; 2008 Jul 21;14(27):4395-9
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  • [Title] AIDS-associated plasmablastic lymphoma presenting as a poorly differentiated esophageal tumor: a diagnostic dilemma.
  • Herein we describe a patient with AIDS who presented with weight loss and dysphagia owing to a large gastroesophageal mass.
  • His radiographic and endoscopic findings and long history of cigarette consumption suggested carcinoma.
  • [MeSH-major] Esophageal Neoplasms / complications. Esophageal Neoplasms / diagnosis. Lymphoma, AIDS-Related / diagnosis. Medical Oncology / methods. Plasma Cells / pathology

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  • (PMID = 18666332.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; EC 3.2.2.5 / Antigens, CD38
  • [Other-IDs] NLM/ PMC2731195
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18. Palefsky J: Human papillomavirus-related disease in people with HIV. Curr Opin HIV AIDS; 2009 Jan;4(1):52-6
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  • [Title] Human papillomavirus-related disease in people with HIV.
  • PURPOSE OF REVIEW: The incidence of human papillomavirus (HPV)-related cancers has increased among people with HIV infection compared with the general population.
  • SUMMARY: New data imply that the problem of HPV-related cancers will not decline among HIV-positive men and women in the antiretroviral therapy era, highlighting the need to perform studies to determine if screening and treatment of anal intraepithelial neoplasia will prevent development of anal cancer.

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  • (PMID = 19339939.001).
  • [ISSN] 1746-6318
  • [Journal-full-title] Current opinion in HIV and AIDS
  • [ISO-abbreviation] Curr Opin HIV AIDS
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA054053-08; United States / NCI NIH HHS / CA / R01 CA054053; United States / NCI NIH HHS / CA / R01 CA088739; United States / NCI NIH HHS / CA / R01 CA054053-08; United States / NCI NIH HHS / CA / R01 CA088739-03; United States / NCI NIH HHS / CA / CA088739-03
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
  • [Number-of-references] 36
  • [Other-IDs] NLM/ NIHMS94538; NLM/ PMC2756707
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19. Mayor AM, Gómez MA, Ríos-Olivares E, Hunter-Mellado RF: AIDS-defining neoplasm prevalence in a cohort of HIV-infected patients, before and after highly active antiretroviral therapy. Ethn Dis; 2008;18(2 Suppl 2):S2-189-94
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  • [Title] AIDS-defining neoplasm prevalence in a cohort of HIV-infected patients, before and after highly active antiretroviral therapy.
  • Implementation of highly active antiretroviral therapy (HAART) has resulted in a dramatic reduction in the HIV/AIDS morbidity and mortality.
  • Neoplasm prevalence was measured, and the difference in AIDS- and non-AIDS-defining neoplasms was analyzed before and after the HAART era.
  • Of these, 51.5% were AIDS-defining neoplasms, and 68% were established before HAART.
  • AIDS-defining neoplasms accounted for 62.4% of those detected before the availability of HAART and 25.9% of those detected after HAART.
  • Except for cervical carcinoma, the prevalence of AIDS-defining neoplasms decreased after HAART.
  • Non-AIDS lymphomas and prostate neoplasms were more frequent after HAART.
  • DISCUSSION: Our study found a significant reduction of Kaposi sarcoma and AIDS-related lymphoma in the HAART era of the AIDS epidemic.
  • A higher prevalence of non-AIDS-defining lymphomas, prostate carcinoma, and cervical carcinoma was seen in the HAART era.

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  • (PMID = 18646347.001).
  • [ISSN] 1049-510X
  • [Journal-full-title] Ethnicity & disease
  • [ISO-abbreviation] Ethn Dis
  • [Language] ENG
  • [Grant] United States / NIMHD NIH HHS / MD / G12 MD007583; United States / NCRR NIH HHS / RR / U54 RR019507; United States / NCRR NIH HHS / RR / G12RR03035; United States / NCRR NIH HHS / RR / 1U54RR01950701; United States / NCRR NIH HHS / RR / G12 RR003035
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS425729; NLM/ PMC3546505
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20. Seoane Lestón J, Diz Dios P: Diagnostic clinical aids in oral cancer. Oral Oncol; 2010 Jun;46(6):418-22
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  • [Title] Diagnostic clinical aids in oral cancer.
  • In the near future, immunological and biochemical alterations in the serum (e.g., circulating immune complexes, carcinoembryonic antigen, squamous cell carcinoma associated antigen, inhibitor of apoptosis, cytokeratin fragments, and annexin A1) as well as specific saliva analysis (e.g., cancer related cytokines, metalloproteinases, epithelial tumour markers, DNA promoter hypermethylation, and saliva micro-RNA) may become important tools for the detection of oral cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Coloring Agents. Luminescence. Mouth Neoplasms / diagnosis. Precancerous Conditions / diagnosis. Tolonium Chloride

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20371204.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coloring Agents; 15XUH0X66N / Tolonium Chloride
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21. Hamdan A, Dezube BJ, Pantanowitz L: Human immunodeficiency virus-associated lung carcinoma presenting as cutaneous metastases. Clin Lung Cancer; 2009 Nov;10(6):441-4
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  • [Title] Human immunodeficiency virus-associated lung carcinoma presenting as cutaneous metastases.
  • In the era of highly active antiretroviral therapy (HAART), HIV-positive individuals are increasingly presenting with non-AIDS-defining cancers such as lung carcinoma.
  • We present 2 cases of lung carcinoma that manifested initially with cutaneous metastases.
  • Both patients were men (37 and 43 years old) with known AIDS that presented with multiple skin nodules mainly on the trunk (back and shoulder).
  • These cases demonstrate that cutaneous metastases might represent the first sign of an internal HIV-related malignancy.
  • With the growing problem of non-AIDS-defining cancers in the current era of HAART, clinicians should be aware that skin lesions in the HIV-infected individual might represent metastatic disease.

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  • (PMID = 19900864.001).
  • [ISSN] 1938-0690
  • [Journal-full-title] Clinical lung cancer
  • [ISO-abbreviation] Clin Lung Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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22. Chaiyachati K, Cinti SK, Kauffman CA, Riddell J: HIV-infected patients with anal carcinoma who subsequently developed oral squamous cell carcinoma: report of 2 cases. J Int Assoc Physicians AIDS Care (Chic); 2008 Nov-Dec;7(6):306-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] HIV-infected patients with anal carcinoma who subsequently developed oral squamous cell carcinoma: report of 2 cases.
  • We describe 2 patients who had human immunodeficiency virus (HIV) infection and who first developed human papillomavirus (HPV)-related anal squamous cell carcinoma and later, oral squamous cell carcinoma.
  • [MeSH-major] Anus Neoplasms / diagnosis. Carcinoma, Squamous Cell / diagnosis. HIV Infections / complications. Mouth Neoplasms / diagnosis. Neoplasms, Second Primary. Papillomavirus Infections / complications


23. Gwede CK, Pow-Sang J, Seigne J, Heysek R, Helal M, Shade K, Cantor A, Jacobsen PB: Treatment decision-making strategies and influences in patients with localized prostate carcinoma. Cancer; 2005 Oct 1;104(7):1381-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment decision-making strategies and influences in patients with localized prostate carcinoma.
  • BACKGROUND: Patients diagnosed with localized prostate carcinoma need to interpret complicated medical information to make an informed treatment selection from among treatments that have comparable efficacy but differing side effects.
  • The authors reported initial results for treatment decision-making strategies among men receiving definitive treatment for localized prostate carcinoma.
  • Long-term data are needed to evaluate distress and decisional regret as patients experience treatment-related chronic side effects and efficacy outcomes.
  • Decision-making aids or other interventions to reduce decisional difficulty and emotional distress during decision making were indicated.

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  • (PMID = 16080181.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Turowski CB, Ross AS, Cusack CA: Human papillomavirus-associated squamous cell carcinoma of the nail bed in African-American patients. Int J Dermatol; 2009 Feb;48(2):117-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus-associated squamous cell carcinoma of the nail bed in African-American patients.
  • BACKGROUND: Human papillomavirus (HPV) has been implicated in the development of digital squamous cell carcinoma (SCC).
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Human papillomavirus 16. Nail Diseases / virology. Papillomavirus Infections / complications. Skin Neoplasms / virology
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. Adult. African Americans. Humans. Male

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  • (PMID = 19200182.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Ye ZB, Ma T, Li H, Jin XL, Xu HM: Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma. World J Gastroenterol; 2007 Mar 21;13(11):1747-51
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  • [Title] Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma.
  • AIM: To explore the effect of intratumoral expressions of interleukin-12 (IL-12) and interleukin-18 (IL-18) on clinical features, angiogenesis and prognosis of gastric carcinoma.
  • IL-12 was significantly associated with pathologic differentiation, depth of invasion, lymph node metastasis, distant metastasis, and TNM stage, and IL-18 was closely related to distant metastasis.
  • Intratumoral IL-12 and IL-18 expressions were not statistically related to MVD scoring.
  • CONCLUSION: The positive expressions of IL-12 and IL-18 can play an important role in progression and metastasis of gastric cancer, and IL-12 might be an independent factor of poor prognosis in gastric carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Mucinous / metabolism. Carcinoma, Signet Ring Cell / metabolism. Interleukin-12 / metabolism. Interleukin-18 / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 17461482.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Interleukin-18; 187348-17-0 / Interleukin-12
  • [Other-IDs] NLM/ PMC4146958
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26. Gichuhi S, Irlam JJ: Interventions for squamous cell carcinoma of the conjunctiva in HIV-infected individuals. Cochrane Database Syst Rev; 2007;(2):CD005643
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Interventions for squamous cell carcinoma of the conjunctiva in HIV-infected individuals.
  • BACKGROUND: Squamous cell carcinoma of the conjunctiva is a rare, slow-growing tumour of the eye, normally affecting elderly men around 70 years of age.
  • This pattern is related to the co-existence of the HIV/AIDS pandemic, high HPV exposure, and solar radiation in the region.
  • This review was conducted to evaluate the interventions for treatment of conjunctival squamous cell carcinoma in HIV-infected individuals.
  • OBJECTIVES: To evaluate the effect of interventions for treating squamous cell carcinoma of the conjunctiva in HIV-infected individuals on local control, recurrence, death, time to recurrence, and adverse events.
  • SEARCH STRATEGY: Using a sensitive search strategy, we attempted to identify all relevant trials, regardless of language or publication status, from the following electronic databases; Medline/PubMed, CENTRAL, AIDSearch, EMBASE, LILACS, African Healthline, Cochrane HIV/AIDS Specialised Register, and the Cochrane Cancer Network Specialised Register.
  • We searched the clinical trial register of the US National Institutes of Health, searched the international conference proceedings of AIDS and AIDS-related cancers, and contacted individual researchers, research organisations, and pharmaceutical companies that manufacture the drugs used as interventions.
  • MAIN RESULTS: No RCTs of interventions currently used against conjunctival squamous cell carcinoma in HIV-infected individuals were identified.
  • AUTHORS' CONCLUSIONS: Current clinical practice in treatment of squamous cell carcinoma of the conjunctiva rests on a weak evidence base of case series and case reports.
  • HIV/AIDS research has not focused on treatment of this tumour.
  • [MeSH-major] Carcinoma, Squamous Cell / therapy. Conjunctival Neoplasms / therapy. HIV Infections / complications

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  • [UpdateIn] Cochrane Database Syst Rev. 2013;2:CD005643 [23450564.001]
  • (PMID = 17443606.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 64
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27. Tornesello ML, Duraturo ML, Guida V, Losito S, Botti G, Pilotti S, Stefanon B, De Palo G, Buonaguro L, Buonaguro FM: Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma. Cancer Lett; 2008 Sep 28;269(1):159-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma.
  • The association of the p53 polymorphism at codon 72 and susceptibility to develop human papillomavirus (HPV)-related cancer has been investigated in several studies with controversial results.
  • In this study, 78 penile squamous cell carcinoma biopsies (n=17 from Uganda, n=61 from Italy) and blood samples from 150 healthy controls (n=57 from Uganda, n=93 from Italy) have been analyzed for the arginine and proline allele distribution.
  • Therefore, no evidence of association between homozygosity for p53 arginine and HPV-related or HPV-unrelated penile squamous cell carcinoma was observed neither among Ugandan nor among Italian populations.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Codon. Genes, p53. Papillomaviridae / isolation & purification. Penile Neoplasms / genetics. Polymorphism, Genetic

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  • (PMID = 18513854.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Codon
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28. García-Fulgueiras A, García-Pina R, Morant C, García-Ortuzar V, Génova R, Alvarez E: Hepatitis C and hepatitis B-related mortality in Spain. Eur J Gastroenterol Hepatol; 2009 Aug;21(8):895-901
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  • [Title] Hepatitis C and hepatitis B-related mortality in Spain.
  • BACKGROUND: Although hepatitis C and hepatitis B virus (HCV/HBV) infections are an important health problem worldwide, their burden of disease (BoD) taking into account their chronic consequences, cirrhosis, and hepatocellular carcinoma (HCC), is still unknown.
  • METHODS: We selected the International Classification of Diseases-Tenth Revision specific codes related to HCV/HBV.
  • We estimated 4342 HCV-related deaths and 877 HBV-related deaths in Spain in 2000, globally 1.5% of total deaths in Spain that year.
  • Mortality by cirrhosis and HCC represented most of these viral-related deaths.
  • Attributable mortality in AIDS patients was also estimated.
  • CONCLUSION: HCV leads the list of infectious disease-related mortality in Spain in 2000, doubling the AIDS mortality even if lower HCV attributable fractions are considered.
  • Exclusion of cirrhosis and HCC-related mortality severely underestimates the BoD attributable to HCV/HBV.
  • [MeSH-major] Carcinoma, Hepatocellular / mortality. Hepatitis B, Chronic / mortality. Hepatitis C, Chronic / mortality. Liver Cirrhosis / mortality. Liver Neoplasms / mortality

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  • (PMID = 19357523.001).
  • [ISSN] 1473-5687
  • [Journal-full-title] European journal of gastroenterology & hepatology
  • [ISO-abbreviation] Eur J Gastroenterol Hepatol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 59
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29. Stebbing J, Krown SE, Bower M, Batra A, Slater S, Serraino D, Dezube BJ, Dhir AA, Pantanowitz L: Primary esophageal carcinoma in the era of highly active antiretroviral therapy. Arch Intern Med; 2010 Jan 25;170(2):203-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary esophageal carcinoma in the era of highly active antiretroviral therapy.
  • BACKGROUND: As human immunodeficiency virus (HIV)-infected individuals are living longer, non-AIDS-defining cancers are becoming increasingly recognized.
  • METHODS: International physicians involved in the care of AIDS-defining and non-AIDS-defining cancers accrued cases of primary esophageal malignant neoplasms in HIV-infected individuals.
  • RESULTS: A total of 19 patients with primary adenocarcinoma and/or squamous cell carcinoma of the esophagus were identified.
  • While the majority of patients died, only 5 deaths (26%) were attributed to progression of esophageal carcinoma.
  • CONCLUSIONS: Primary esophageal carcinoma is another non-AIDS-defining cancer associated with moderate immunosuppression and lifestyle habits including tobacco and alcohol use.
  • The biological behavior, treatment, and outcome of HIV-related esophageal cancer appear similar to the general population with this disease; the same screening and risk moderation strategies are likely to apply.
  • [MeSH-major] Adenocarcinoma / complications. Antiretroviral Therapy, Highly Active. Carcinoma, Squamous Cell / complications. Esophageal Neoplasms / complications. HIV Infections / complications


30. Sahali S, Bichet JC, Delfraissy JF, Ghosn J: Breast enlargement in an HIV-infected man on combined antiretroviral therapy: what if it was carcinoma? Int J STD AIDS; 2010 May;21(5):373-4
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  • [Title] Breast enlargement in an HIV-infected man on combined antiretroviral therapy: what if it was carcinoma?
  • We describe a case of an HIV-infected man on effective combined antiretroviral therapy, presenting with bilateral gynaecomastia revealing breast carcinoma.
  • Gynaecomastia was first considered to be related to efavirenz and/or didanosine.
  • Although breast carcinoma is rare among HIV-infected men, it should be considered as a potential cause of breast enlargement.
  • [MeSH-major] Breast Neoplasms, Male / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Gynecomastia / etiology. HIV Infections / drug therapy. Reverse Transcriptase Inhibitors / adverse effects

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  • (PMID = 20498112.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzoxazines; 0 / Reverse Transcriptase Inhibitors; 2T8Q726O95 / Lamivudine; JE6H2O27P8 / efavirenz; K3GDH6OH08 / Didanosine
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31. Tornesello ML, Duraturo ML, Botti G, Greggi S, Piccoli R, De Palo G, Montella M, Buonaguro L, Buonaguro FM, Italian HPV Working Group: Prevalence of alpha-papillomavirus genotypes in cervical squamous intraepithelial lesions and invasive cervical carcinoma in the Italian population. J Med Virol; 2006 Dec;78(12):1663-72
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  • [Title] Prevalence of alpha-papillomavirus genotypes in cervical squamous intraepithelial lesions and invasive cervical carcinoma in the Italian population.
  • Among the 205 HPV-positive patients, a total of 31 mucosal HPV genotypes were identified of which 16 types, epidemiological classified as high-risk viruses (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 66, 68, 73, and 82), have been found in 16.9%, 50.1%, 69.2%, and 78.5% of normal cervix, low-, and high-grade cervical squamous intraepithelial lesions, and cervical carcinoma groups, respectively.
  • As expected, the HPV16 was the most represented viral type in all groups examined with frequency rates ranging from 8.7% in normal subjects to 58.5% in invasive carcinoma patients.
  • Larger epidemiological screening studies, with PCR amplification and followed by either hybridization-based procedures against sequence targets of all known HPV types or sequence analysis studies, are needed in order to assess the epidemiological risk of less represented HPV types, to identify unknown viruses, and to monitor the future eventual spread of unusual viral types related to vaccination programs and/or population mobility.
  • [MeSH-major] Alphapapillomavirus / classification. Alphapapillomavirus / genetics. Carcinoma, Squamous Cell / virology. Cervical Intraepithelial Neoplasia / virology. Papillomavirus Infections / virology. Uterine Cervical Neoplasms / virology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 17063505.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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32. Holkar S, Mudhar HS, Jain A, Gupta M, Rogstad KE, Parsons MA, Singh AD, Rennie IG: Regression of invasive conjunctival squamous carcinoma in an HIV-positive patient on antiretroviral therapy. Int J STD AIDS; 2005 Dec;16(12):782-3
HIV InSite. treatment guidelines - Ophthalmic Manifestations of HIV .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regression of invasive conjunctival squamous carcinoma in an HIV-positive patient on antiretroviral therapy.
  • A conjunctival biopsy revealed invasive squamous cell carcinoma, with orbital invasion on computed tomography scan.
  • Discussion covers conjunctival carcinoma and behaviour of HIV-related tumours with antiretroviral therapy.
  • [MeSH-major] Antiretroviral Therapy, Highly Active / adverse effects. Carcinoma, Squamous Cell / etiology. Conjunctival Neoplasms / etiology. HIV Infections / complications


33. Yu JJ, Fu P, Pink JJ, Dawson D, Wasman J, Orem J, Mwanda WO, Zhu H, Liang X, Guo Y, Petros WP, Mitsuyasu RT, Wabinga H, Remick SC: HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma. PLoS One; 2010 May 17;5(5):e10477
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  • [Title] HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma.
  • BACKGROUND: There has been substantial growth in the numbers of patients with conjunctival squamous cell carcinoma infected with HIV in East Africa.
  • The natural history of the conjunctival squamous cell carcinoma appears to be unique in this region of the world, but the etiologic mechanism unclear and therapeutic options limited.
  • This research was carried out to determine if conjunctival squamous cell carcinoma harbors human papillomavirus DNA and is associated with activation of the EGFR signaling pathway.
  • Immunohistochemistry and qPCR data suggest that activation and expression of the EGFR signaling pathway is related to disease progression of conjunctival cancer.
  • CONCLUSIONS/SIGNIFICANCE: We conclude that HPV types 16/18 infection is frequent in East African patients with AIDS-associated squamous cell carcinoma of the conjunctiva.
  • Our findings hint that adoption of HPV vaccination strategies may impact the incidence of conjunctival carcinoma.

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  • (PMID = 20498858.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / U01 CA070081; United States / NCI NIH HHS / CA / P30 CA043703; United States / NCI NIH HHS / CA / CA43703; United States / NCI NIH HHS / CA / CA70081; United States / NCI NIH HHS / CA / CA121947; United States / NCI NIH HHS / CA / CA70091; United States / NCI NIH HHS / CA / P30 CA43703; United States / NCI NIH HHS / CA / T32 CA070091; United States / NCI NIH HHS / CA / U01 CA121947
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.24 / Mitogen-Activated Protein Kinases
  • [Other-IDs] NLM/ PMC2871792
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34. Baillargeon J, Snyder N, Soloway RD, Paar D, Baillargeon G, Spaulding AC, Pollock BH, Arcari CM, Williams BA, Raimer BG: Hepatocellular carcinoma prevalence and mortality in a male state prison population. Public Health Rep; 2009 Jan-Feb;124(1):120-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hepatocellular carcinoma prevalence and mortality in a male state prison population.
  • OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) in the United States has increased dramatically over the last two decades, largely because of an increase in the number of people with advanced hepatitis C virus (HCV) infection. U.S. prisoners are at high risk for HCC, given their elevated rates of HCV infection, comorbid hepatitis B virus (HBV) infection, and alcoholic liver disease.
  • These findings likely reflect the high concentration of HCC-related risk factors, particularly HCV, among prisoners.
  • [MeSH-major] Carcinoma, Hepatocellular / mortality. Liver Neoplasms / mortality. Prisoners

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  • (PMID = 19413034.001).
  • [ISSN] 0033-3549
  • [Journal-full-title] Public health reports (Washington, D.C. : 1974)
  • [ISO-abbreviation] Public Health Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2602937
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35. Leone N, Rizzetto M: Natural history of hepatitis C virus infection: from chronic hepatitis to cirrhosis, to hepatocellular carcinoma. Minerva Gastroenterol Dietol; 2005 Mar;51(1):31-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history of hepatitis C virus infection: from chronic hepatitis to cirrhosis, to hepatocellular carcinoma.
  • In patients with cirrhosis, the incidence of hepatocellular carcinoma is 2-5% per year.
  • At present, HCV-related end-stage cirrhosis is the first cause of liver transplantation.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Hepatitis C / complications. Hepatitis C, Chronic / complications. Liver Cirrhosis / etiology. Liver Neoplasms / etiology
  • [MeSH-minor] AIDS-Related Opportunistic Infections. Adult. Clinical Enzyme Tests. Disease Progression. Female. Follow-Up Studies. Genotype. Hepacivirus / genetics. Humans. Immunocompromised Host. Liver Transplantation. Male. RNA, Viral / analysis. Time Factors. Viral Load

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  • (PMID = 15756144.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / RNA, Viral
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36. Meyer-Ruesenberg B, Richard G: [New insights into the underestimated impairment of quality of life in age-related macular degeneration - a review of the literature]. Klin Monbl Augenheilkd; 2010 Aug;227(8):646-52
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  • [Title] [New insights into the underestimated impairment of quality of life in age-related macular degeneration - a review of the literature].
  • Different forms of age-related macular degeneration (AMD) can lead to massive visual impairment up to blindness.
  • It demonstrates the relevance of AMD for patients and shows that its impact on patients' life is comparable to those of other systemic diseases like carcinoma or HIV.
  • These patients benefit from rehabilitation with low vision aids or psychosocial interventions.
  • [MeSH-minor] Activities of Daily Living / psychology. Aged. Blindness / psychology. HIV Infections / psychology. Humans. Neoplasms / psychology. Sensory Aids. Sick Role

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  • [Copyright] Georg Thieme Verlag KG Stuttgart, New York.
  • (PMID = 20449793.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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37. Jainkittivong A, Swasdison S, Thangpisityotin M, Langlais RP: Oral squamous cell carcinoma: a clinicopathological study of 342 Thai cases. J Contemp Dent Pract; 2009;10(5):E033-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral squamous cell carcinoma: a clinicopathological study of 342 Thai cases.
  • AIM: To conduct a clinicopathological review of oral squamous cell carcinoma (SCC) and to analyze it with respect to gender, age at diagnosis, clinical presentation, lesion location, and histological grading.
  • CONCLUSION: In the present study, the incidence of SCC was age-related and showed equal gender distribution.
  • CLINICAL SIGNIFICANCE: Routine examination of the oral cavity by dental practitioners and other health care providers aids in the early detection of premalignant and malignant oral disease.
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Gingival Neoplasms / epidemiology. Mouth Neoplasms / epidemiology


38. Gaughan EM, Dezube BJ, Aboulafia D, Bower M, Stebbing J, Powles T, Pantanowitz L: Human immunodeficiency virus--associated renal cell carcinoma: a transatlantic case series. Clin Genitourin Cancer; 2008 Sep;6(2):86-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human immunodeficiency virus--associated renal cell carcinoma: a transatlantic case series.
  • Non-AIDS-defining cancers, including renal cell carcinoma (RCC), are being recognized increasingly in this population.
  • RESULTS: Renal cell carcinoma was diagnosed in patients with a median age of 48 years, and most had a history of tobacco use.
  • No association between HIV-related immunosuppression (mean CD4 count, 301 cells/mm3) and the development, clinical presentation, pathology, or behavior of RCC was identified.
  • CONCLUSION: Renal cell carcinoma should be included in the expanding array of non-AIDS-defining malignancies that develop during the course of HIV infection.
  • [MeSH-major] Carcinoma, Renal Cell / complications. HIV Infections / complications. Kidney Neoplasms / complications


39. Koljonen V, Kukko H, Pukkala E, Sankila R, Böhling T, Tukiainen E, Sihto H, Joensuu H: Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma. Br J Cancer; 2009 Oct 20;101(8):1444-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma.
  • BACKGROUND: Immunosuppression and Merkel-cell polyomavirus (MCPyV) infection may have a role in the pathogenesis of Merkel-cell carcinoma (MCC), a rare neuroendocrine carcinoma of the skin.
  • Immunosuppression related with CLL and viral infection might explain the association between CLL and MCC.
  • [MeSH-major] Carcinoma, Merkel Cell / etiology. Leukemia, Lymphocytic, Chronic, B-Cell / complications. Merkel Cells / virology. Polyomavirus / isolation & purification

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  • (PMID = 19755994.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Other-IDs] NLM/ PMC2768432
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40. Sharma R, Iyer M: Bowen's disease of the nipple in a young man with AIDS: a case report. Clin Breast Cancer; 2009 Feb;9(1):53-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bowen's disease of the nipple in a young man with AIDS: a case report.
  • Bowen's disease, or squamous cell carcinoma in situ (SCCIS) of the skin, is a malignant neoplasm restricted to the epidermis, without evidence of dermal invasion.
  • There was no evidence of invasive carcinoma.
  • With the advent of highly active antiretroviral treatment, chronic non-HIV related conditions have become more important, male breast cancer being one of them.


41. Manfredi R, Sabbatani S, Gianelli U, Marinacci G: Epstein-Barr Virus Associated Nasopharyngeal Carcinoma and Local Polymorphic B-Cell Lymphoproliferative Disorder in a Patient With HIV Disease. J Int Assoc Physicians AIDS Care (Chic); 2007 Dec;6(4):255-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epstein-Barr Virus Associated Nasopharyngeal Carcinoma and Local Polymorphic B-Cell Lymphoproliferative Disorder in a Patient With HIV Disease.
  • A rare case report of HIV-associated nasopharyngeal carcinoma concurrent with local polymorphic B-cell lymphoproliferative disorder is reported and discussed on the ground of the most recent literature evidences.
  • Only very few reports of nasopharyngeal carcinoma have been described until now in patients infected with HIV (one case in adults), and a coexisting lymphoid cell proliferation with a concurrent role of Epstein-Barr virus in prompting both disorders was never reported to date.
  • The relevant pathogenetic, diagnostic, and therapeutic questions raised by this infrequent intriguing association retrieved in a patient with prominent HIV-related immunodeficiency are focused on.

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  • (PMID = 17554142.001).
  • [ISSN] 1557-0886
  • [Journal-full-title] Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
  • [ISO-abbreviation] J Int Assoc Physicians AIDS Care (Chic)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Rosenthal E, Pialoux G, Bernard N, Pradier C, Rey D, Bentata M, Michelet C, Pol S, Perronne C, Cacoub P, GERMIVIC Joint Study Group: Liver-related mortality in human-immunodeficiency-virus-infected patients between 1995 and 2003 in the French GERMIVIC Joint Study Group Network (MORTAVIC 2003 Study). J Viral Hepat; 2007 Mar;14(3):183-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver-related mortality in human-immunodeficiency-virus-infected patients between 1995 and 2003 in the French GERMIVIC Joint Study Group Network (MORTAVIC 2003 Study).
  • Among 215 deaths observed during 2003, 101 (46.9%) were related to AIDS, 27 (12.6%) to ESLD and 87 (40.5%) to other causes.
  • Mortality because of ESLD represented 23.7% of non-AIDS-related deaths.
  • The prevalence of hepatocellular carcinoma as a cause of death remained high in 2003 but stable when compared with 2001 (25%vs 14.8%).
  • [MeSH-minor] Adult. Aged. Carcinoma, Hepatocellular / mortality. Female. France. Hepatitis C, Chronic / mortality. Humans. Liver Diseases, Alcoholic / mortality. Liver Neoplasms / mortality. Male. Middle Aged

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  • (PMID = 17305884.001).
  • [ISSN] 1352-0504
  • [Journal-full-title] Journal of viral hepatitis
  • [ISO-abbreviation] J. Viral Hepat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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43. Merchante N, Jiménez-Saenz M, Pineda JA: Management of HCV-related end-stage liver disease in HIV-coinfected patients. AIDS Rev; 2007 Jul-Sep;9(3):131-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of HCV-related end-stage liver disease in HIV-coinfected patients.
  • Ascites and hepatic encephalopathy are much more frequent, whereas hepatocellular carcinoma is still uncommon, when simultaneous hepatitis B virus infection is absent.
  • [MeSH-minor] Ascites / etiology. Ascites / therapy. Carcinoma, Hepatocellular / complications. Carcinoma, Hepatocellular / virology. Disease Progression. Hepatic Encephalopathy / etiology. Hepatic Encephalopathy / therapy. Hepatitis B / complications. Hepatorenal Syndrome / etiology. Hepatorenal Syndrome / therapy. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / etiology. Liver Neoplasms / therapy. Liver Transplantation. Peritonitis / drug therapy. Peritonitis / prevention & control


44. Berretta M, Zanet E, Di Benedetto F, Simonelli C, Bearz A, Morra A, Bonanno S, Berretta S, Tirelli U: Unusual presentation of metastatic hepatocellular carcinoma in an HIV/HCV coinfected patient: case report and review of the literature. Tumori; 2008 Jul-Aug;94(4):589-91
HIV InSite. treatment guidelines - Coinfection with Hepatitis Viruses and HIV .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unusual presentation of metastatic hepatocellular carcinoma in an HIV/HCV coinfected patient: case report and review of the literature.
  • Hepatocellular carcinoma (HCC) is an increasing cause of mortality in human immunodeficiency virus (HIV) seropositive patients.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Carcinoma, Hepatocellular / diagnosis. Hepatitis C / complications. Liver Neoplasms / diagnosis


45. Rosenthal E, Salmon-Céron D, Lewden C, Bouteloup V, Pialoux G, Bonnet F, Karmochkine M, May T, François M, Burty C, Jougla E, Costagliola D, Morlat P, Chêne G, Cacoub P, Mortavic/Mortalité 2005 Study Group: Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 study in collaboration with the Mortalité 2005 survey, ANRS EN19). HIV Med; 2009 May;10(5):282-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 study in collaboration with the Mortalité 2005 survey, ANRS EN19).
  • Results Among 287 reported deaths in 2005, 100 (35%) were related to AIDS, and 48 (17%) to ESLD.
  • Three out of four patients who died from ESLD-related causes had chronic hepatitis C.
  • The proportion of deaths caused by hepatocellular carcinoma increased from 5% in 1995 to 25% in 2005 (P=0.0337).
  • CONCLUSIONS: Over the 10 years from 1995 to 2005, the proportion of deaths caused by hepatitis C virus-related ESLD has increased in HIV-infected patients.
  • ESLD is currently a leading cause of death in this population, with hepatocellular carcinoma representing a quarter of liver-related deaths.
  • Recommendations for the detection of hepatocellular carcinoma should be strictly applied in these patients.
  • [MeSH-major] Carcinoma, Hepatocellular / mortality. HIV Infections / mortality. Hepatitis C, Chronic / mortality. Liver Neoplasms / mortality

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  • (PMID = 19226410.001).
  • [ISSN] 1468-1293
  • [Journal-full-title] HIV medicine
  • [ISO-abbreviation] HIV Med.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
  • [Investigator] Pautard-Huchemblé B; Schmit JL; Bonnefoy M; Bru JP; Gaillat J; Lerousseau L; Dubois D; Azzedine A; De La Blanchardière A; Lepeu G; Faller JP; Balvay P; Barale F; Estavoyer JM; Vuitton D; Bentata M; Cohen P; Guillevin L; Jarrousse B; Padrazzi B; Beylot J; Bernard N; Constans J; Loury I; Moreau F; Morlat P; Ragnaud JM; Viaud JF; Lacoste D; Baglin A; Dorra M; Dupont C; Hanslik T; Rouveix E; Granier P; Cénac A; Bazin C; Hazera P; Verdon R; Schmidt J; Rogeaux O; Menalba C; Boué F; Fior R; Galanaud P; Pik JJ; Beytout J; Laurichesse H; Ruivard M; Laplatte G; Audoy B; Plaisance N; Bouterra C; Laylotte G; Delarocque E; Vinceneux P; Lesprit P; Schaeffer A; Grappin M; Greuzard MC; Loudes-Chauvin MC; Portier H; Vinceneux M; Guillaumie J; Dournovo P; De Truchis P; Perronne C; Bouchard O; Micoud M; Morand P; Boucher J; Chambourlier P; Renou C; Arvin-Berod C; Poubeau P; Perre P; Hachulla E; Devulder B; Hatron PY; Loustaud-Ratti V; Berthou JD; Baborier D; Constant E; Dufay E; Peyramond D; Trémolières F; Bourgeade A; Durand JM; Gastaut JA; Gallais H; Moreau J; Perret JL; Poizot-Martin I; Soubeyrand J; Meissonnier P; Hayek R; Constant C; Raabe JJ; Wang A; Astruc J; Blanc F; Perney P; Vandôme A; Bautoille D; Guerbois C; Loyau C; Raffi F; Villers D; Burty C; Canton P; de Korwin JD; Thibaut G; Wahl D; Dellamonica P; Cassuto JP; Ceppi C; Fuzibet JG; Poirée M; Pradier C; Rosenthal E; Raffanel C; Amoura Z; Aumaitre H; Bani-Sadr F; Bergmann JF; Bissuel F; Boissonnas A; Bouvet E; Bricaire F; Cabane J; Cabié A; Cacoub P; Caquet R; Carbon C; Caulin C; Chemlal K; Coulaud JP; de Beaumont T; Devars du Mayne F; Dupont C; Durand B; Farge D; Galanaud P; Gaudebout C; Gilquin J; Goujard C; Hausfater P; Katlama C; Karmochkine M; Krainik F; Le Bras P; Le Moing V; Leport C; Modaï J; Molina JM; Pialoux G; Piette JC; Poinsignon Y; Quertainmont Y; Raguin G; Rozenbaum W; Sicard D; Simon J; Vachon F; Valleron AJ; Vildé JL; Arsac P; Calamy G; Mille C; Mercie P; Pellegrin JL; Becq-Giraudon B B; Breux JP; Le Moal G; Michelet C; Cartier F; Beguinot I; Rémy G; Gueit I; Borsa-Lebas F; Humbert G; Wemeau J; Hascouet C; Le Cam B; Khuong MA; Mechali D; Roblin X; Defontaine C; Lucht F; Fégueux S; Veyssier-Belot C; Ouzan D; Kitschke B; Clément-Bertoldo C; Gonzales G; Poubeau P; Fischer P; Lang JM; Rey D; Ruellan A; Schlienger JL; Zucman D; Blétry O; Romand P; Alric L; Cuzin L; Duffaut M; Ajana F; Mouton Y; Yazdanpanah Y; Borderon JC; Choutet P; Guimard Y; Patey O
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46. Maggiorella L, Wen B, Frascogna V, Opolon P, Bourhis J, Deutsch E: Combined radiation sensitizing and anti-angiogenic effects of ionizing radiation and the protease inhibitor ritonavir in a head and neck carcinoma model. Anticancer Res; 2005 Nov-Dec;25(6B):4357-62
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Combined radiation sensitizing and anti-angiogenic effects of ionizing radiation and the protease inhibitor ritonavir in a head and neck carcinoma model.
  • Reports of dramatic improvement of AIDS-related cancers, such as primary central system lymphoma after radiation therapy as well as Kaposi's sarcoma, led to the recent discovery of the "non viral" antitumor activity of HIV protease inhibitors.
  • This study was designed to detect the antitumor effect of Ritonavir when combined with ionizing radiation both in vitro and in vivo in the HEP-2 head and neck carcinoma model.
  • These data suggested that Ritonavir could clinically improve the tumor response to radiation therapy, especially in head and neck carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / radiotherapy. Ritonavir / pharmacology

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  • (PMID = 16309240.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Radiation-Sensitizing Agents; O3J8G9O825 / Ritonavir
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47. García-García JA, Romero-Gómez M, Girón-González JA, Rivera-Irigoin R, Torre-Cisneros J, Montero JL, González-Serrano M, Andrade RJ, Aguilar-Guisado M, Grilo I, Martín-Vivaldi J, Salmerón J, Caballero-Granado FJ, Macías J, Vergara-López S, Pineda JA, Grupo Andaluz para el Estudio de las Enfermedades Infecciosas (GAEI), Grupo Andaluz para el Estudio del Hígado (GAEH): Incidence of and factors associated with hepatocellular carcinoma among hepatitis C virus and human immunodeficiency virus coinfected patients with decompensated cirrhosis. AIDS Res Hum Retroviruses; 2006 Dec;22(12):1236-41
HIV InSite. treatment guidelines - Coinfection with Hepatitis Viruses and HIV .

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  • [Title] Incidence of and factors associated with hepatocellular carcinoma among hepatitis C virus and human immunodeficiency virus coinfected patients with decompensated cirrhosis.
  • We compared the incidence of and factors associated with hepatocellular carcinoma (HCC) among hepatitis C virus (HCV)-monoinfected subjects and human immunodeficiency virus (HIV)/HCV-coinfected individuals, both with decompensated cirrhosis.
  • In a retrospective study, a cohort of 180 individuals with HIV coinfection and 1037 HCV-monoinfected patients with decompensated HCV-related cirrhosis from eight centres in Spain were analyzed.
  • The incidence of HCC in patients with HCV-related cirrhosis after the first hepatic decompensation is lower in HIV-coinfected patients.
  • [MeSH-major] Carcinoma, Hepatocellular / epidemiology. Carcinoma, Hepatocellular / virology. HIV Infections / complications. Hepatitis C, Chronic / complications. Liver Cirrhosis / complications. Liver Neoplasms / epidemiology. Liver Neoplasms / virology


48. Roma AA, Goldblum JR, Fazio V, Yang B: Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma. Int J Clin Exp Pathol; 2008;1(5):419-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma.
  • 14-3-3sigma is a p53-regulated G2/M inhibitor involved in numerous cellular signaling pathways related to cell cycle, DNA repair and apoptosis.
  • Recent studies have showed that 14-3-3sigma was silenced transcriptionally through promoter hypermethylation mainly in HPV-negative vulvar squamous cell carcinoma (SCC).

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  • (PMID = 18787619.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480570
  • [Keywords] NOTNLM ; 14-3-3σ / AIN / Anal intraepithelial neoplasm / Bowenoid / differentiated / p16 / p53 / simplex
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49. Gulley ML, Tang W: Laboratory assays for Epstein-Barr virus-related disease. J Mol Diagn; 2008 Jul;10(4):279-92
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  • [Title] Laboratory assays for Epstein-Barr virus-related disease.
  • Laboratory tests for EBV have improved and are increasingly used in diagnosis, prognosis, prediction, and prevention of diseases ranging from infectious mononucleosis to selected subtypes of lymphoma, sarcoma, and carcinoma.
  • Other RNA- and protein-based assays detect lytic viral replication and can distinguish carcinoma-derived from lymphocyte-derived EBV in saliva or nasopharyngeal brushings.
  • Such assays have been incorporated into standard clinical practice in selected settings such as diagnosis of primary infection and management of patients with immune dysfunction or nasopharyngeal carcinoma.

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  • (PMID = 18556771.001).
  • [ISSN] 1525-1578
  • [Journal-full-title] The Journal of molecular diagnostics : JMD
  • [ISO-abbreviation] J Mol Diagn
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / Viral Proteins
  • [Number-of-references] 146
  • [Other-IDs] NLM/ PMC2438195
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50. Takacs M, Segesdi J, Banati F, Koroknai A, Wolf H, Niller HH, Minarovits J: The importance of epigenetic alterations in the development of epstein-barr virus-related lymphomas. Mediterr J Hematol Infect Dis; 2009;1(2):e2009012
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  • [Title] The importance of epigenetic alterations in the development of epstein-barr virus-related lymphomas.
  • These include lymphomas (Burkitt's lymphoma, Hodgkin's disease, T/NK-cell lymphoma, post-transplant lymphoproliferative disease, AIDS-associated lymphoma, X-linked lymphoproliferative syndrome), carcinomas (nasopharyngeal carcinoma, gastric carcinoma, carcinomas of major salivary glands, thymic carcinoma, mammary carcinoma) and a sarcoma (leiomyosarcoma).

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  • (PMID = 21416002.001).
  • [ISSN] 2035-3006
  • [Journal-full-title] Mediterranean journal of hematology and infectious diseases
  • [ISO-abbreviation] Mediterr J Hematol Infect Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3033174
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51. Handisurya A, Rieger A, Bankier A, Koller A, Salat A, Stingl G, Kirnbauer R: Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy. Br J Dermatol; 2007 Oct;157(4):788-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy.
  • Squamous cell carcinoma (SCC) of the nail unit is a rare disorder.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Alphapapillomavirus / classification. Carcinoma, Squamous Cell / virology. Nails. Papillomavirus Infections / complications. Skin Neoplasms / virology

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  • (PMID = 17634082.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / P 18990
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ EMS55131; NLM/ PMC3935457
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52. Buonaguro L, Petrizzo A, Tornesello M, Napolitano M, Martorelli D, Castello G, Beneduce G, De Renzo A, Perrella O, Romagnoli L, Sousa V, De Re V, Dolcetti R, Buonaguro FM: Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders. J Transl Med; 2010;8:18
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  • [Title] Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders.
  • Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may further evolve into an overt B-cell non-Hodgkin's lymphoma (NHL).

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  • (PMID = 20170491.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cytokines; 0 / Immunoglobulin Idiotypes; 0 / Immunoglobulin Variable Region; 0 / Receptors, Antigen, B-Cell; 0 / Viral Vaccines
  • [Other-IDs] NLM/ PMC2839974
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53. Aulmann S, Schleibaum J, Penzel R, Schirmacher P, Gebauer G, Sinn HP: Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status. J Clin Pathol; 2008 Sep;61(9):1034-7
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  • [Title] Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status.
  • (1) usual-type (bowenoid) VIN, which is related to high-risk papillomavirus infection, and (2) differentiated (simplex) VIN, which is associated with chronic inflammation.
  • CONCLUSIONS: Immunohistochemical evaluation of p16 and p53 expression aids in the differential diagnosis of squamous cell alterations of the vulva.
  • [MeSH-major] Carcinoma in Situ / genetics. Carcinoma, Squamous Cell / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 3 / genetics. Vulvar Neoplasms / genetics

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  • (PMID = 18559375.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p53
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54. Yu J, Solano FX Jr, Seethala RR: Bilateral cytomegalovirus (CMV) oophoritis mimicking widely metastatic carcinoma: a case report and review of the literature. Diagn Pathol; 2007;2:50
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  • [Title] Bilateral cytomegalovirus (CMV) oophoritis mimicking widely metastatic carcinoma: a case report and review of the literature.
  • While age related vasculopathy was thought to be the prevailing mechanism for CMV oophoritis, the observation of an inflammation mediated microthrombosis in our case provides a plausible age independent mechanism suggesting that both restrictive and obstructive vascular changes can be involved in the pathogenesis of CMV oophoritis.

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  • (PMID = 18096056.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2245911
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55. Moncayo R, Kroiss A, Oberwinkler M, Karakolcu F, Starzinger M, Kapelari K, Talasz H, Moncayo H: The role of selenium, vitamin C, and zinc in benign thyroid diseases and of selenium in malignant thyroid diseases: Low selenium levels are found in subacute and silent thyroiditis and in papillary and follicular carcinoma. BMC Endocr Disord; 2008;8:2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of selenium, vitamin C, and zinc in benign thyroid diseases and of selenium in malignant thyroid diseases: Low selenium levels are found in subacute and silent thyroiditis and in papillary and follicular carcinoma.
  • BACKGROUND: Thyroid physiology is closely related to oxidative changes.
  • Se levels were significantly decreased in cases of sub-acute and silent thyroiditis (66.4 +/- 23.1 microg/l and 59.3 +/- 20.1 microg/l, respectively) as well as in follicular and papillary thyroid carcinoma.

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  • (PMID = 18221503.001).
  • [ISSN] 1472-6823
  • [Journal-full-title] BMC endocrine disorders
  • [ISO-abbreviation] BMC Endocr Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2266752
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56. Epstein JB, Gorsky M, Cabay RJ, Day T, Gonsalves W: Screening for and diagnosis of oral premalignant lesions and oropharyngeal squamous cell carcinoma: role of primary care physicians. Can Fam Physician; 2008 Jun;54(6):870-5
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  • [Title] Screening for and diagnosis of oral premalignant lesions and oropharyngeal squamous cell carcinoma: role of primary care physicians.
  • OBJECTIVE; To describe the role that primary care physicians can play in early recognition of oral and oropharyngeal squamous cell carcinomas (OOSCCs) and to review the risk factors for OOSCCs, the nature of oral premalignant lesions, and the technique and aids for clinical examination.
  • Early recognition and diagnosis of OOSCCs might improve patient survival and reduce treatment-related morbidity.
  • [MeSH-major] Carcinoma, Squamous Cell / prevention & control. Mass Screening. Mouth Neoplasms / prevention & control. Oropharyngeal Neoplasms / prevention & control. Precancerous Conditions / prevention & control

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  • (PMID = 18556495.001).
  • [ISSN] 1715-5258
  • [Journal-full-title] Canadian family physician Médecin de famille canadien
  • [ISO-abbreviation] Can Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Number-of-references] 46
  • [Other-IDs] NLM/ PMC2426981
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57. Potthoff A, Brockmeyer NH: [HIV-associated tumors]. Hautarzt; 2006 Nov;57(11):988, 990-3
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • In the beginning of the HIV epidemic, Kaposi sarcoma was a common stigma in AIDS patients and one of the leading causes of death.
  • The incidence of HPV-related anal carcinoma and its precursor lesions is rising so dramatically that screening programs as they are already established for cervical carcinoma should be implemented.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. Adult. Antiretroviral Therapy, Highly Active. Anus Neoplasms / etiology. Carcinoma, Hepatocellular / etiology. Female. HIV Seropositivity / complications. Humans. Liver Neoplasms / etiology. Lung Neoplasms / drug therapy. Lung Neoplasms / etiology. Lymphoma, AIDS-Related / diagnosis. Lymphoma, AIDS-Related / drug therapy. Lymphoma, AIDS-Related / etiology. Male. Middle Aged. Papillomavirus Infections / complications. Risk Factors. Skin Neoplasms / etiology. Smoking / adverse effects. Uterine Cervical Neoplasms / etiology

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  • (PMID = 17036250.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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58. Epstein JB, Cabay RJ, Glick M: Oral malignancies in HIV disease: changes in disease presentation, increasing understanding of molecular pathogenesis, and current management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2005 Nov;100(5):571-8
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  • Infection with human immunodeficiency virus (HIV) and progression to acquired immune deficiency syndrome (AIDS) are associated with a vide variety of morbidities.
  • This paper discusses recent trends in the presentation and treatment of malignancies related to HIV and AIDS with an emphasis on malignancies seen in the oral cavity.
  • [MeSH-minor] Animals. Antiretroviral Therapy, Highly Active. Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / therapy. Carcinoma, Squamous Cell / virology. DNA, Viral / analysis. Developed Countries. Herpesvirus 4, Human / isolation & purification. Humans. Lymphoma, AIDS-Related / complications. Lymphoma, AIDS-Related / epidemiology. Lymphoma, AIDS-Related / therapy. Prevalence. Sarcoma, Kaposi / complications. Sarcoma, Kaposi / epidemiology. Sarcoma, Kaposi / therapy. United States / epidemiology

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  • (PMID = 16243242.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Number-of-references] 82
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59. Ho-Yen C, Chang F, van der Walt J, Lucas S: Gastrointestinal malignancies in HIV-infected or immunosuppressed patients: pathologic features and review of the literature. Adv Anat Pathol; 2007 Nov;14(6):431-43
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • The gastrointestinal (GI) tract is a common internal organ to be involved by human immunodeficiency virus (HIV)-related malignancies.
  • It is the second most common site for Kaposi sarcoma after skin, and the commonest visceral site, for Kaposi sarcoma in AIDS patients.
  • GI lymphomas have been documented in approximately 25% of AIDS patients with systemic lymphomas.
  • Moreover, GI involvement of AIDS-lymphoma has been associated with poor prognosis and short survival.
  • Several other malignancies that occur in the GI tract are also closely related to HIV-infected or immunosuppressed individuals; these include posttransplant lymphoproliferative disorder, Epstein-Barr virus-associated smooth muscle tumors, anal precancerous lesions, and squamous cell carcinoma.
  • Therefore, it is possible that the number of AIDS-associated malignancies will rise and the pattern of tumors may change in the future.
  • In this paper, the clinicopathologic features of GI malignancies associated with AIDS patients are reviewed and the differential diagnosis with other mimic lesions is discussed.
  • [MeSH-major] Acquired Immunodeficiency Syndrome / pathology. Gastrointestinal Neoplasms / pathology. Immunocompromised Host. Immunosuppression. Lymphoma, AIDS-Related / pathology. Sarcoma, Kaposi / pathology

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  • (PMID = 18049132.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 103
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60. Loya AC, Prayaga AK, Sundaram C, Shantharam V, Kumar A: Cytologic diagnosis of pancreatic tuberculosis in immunocompetent and immunocompromised patients: a report of 2 cases. Acta Cytol; 2005 Jan-Feb;49(1):97-100
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • Pancreatic involvement by tuberculosis in immunocompromised states, such as AIDS, and isolated involvement in immunocompetent patients require a high index of suspicion.
  • CASES: A patient presented with diabetes mellitus and a pancreatic mass clinically diagnosed as pancreatic carcinoma.
  • [MeSH-minor] AIDS-Related Opportunistic Infections. Adult. Biopsy, Fine-Needle. Carcinoma / diagnosis. Diabetes Mellitus / physiopathology. Diagnosis, Differential. Fatal Outcome. HIV Seropositivity. Humans. Immunocompromised Host. Lymphatic Diseases / pathology. Lymphoma, Non-Hodgkin / diagnosis. Male. Middle Aged. Pancreas / pathology. Pancreas / radiography. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 15717764.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Ramdial PK, Sing Y, Chotey NA, Bagratee JS: Concomitant malacoplakia and granuloma inguinale of the cervix in acquired immune deficiency syndrome. Int J Gynecol Pathol; 2008 Apr;27(2):282-7
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  • We describe concomitant granuloma inguinale (GI) and malacoplakia of the cervix in 2 acquired immune deficiency syndrome (AIDS) patients aged 27 and 36 years.
  • Speculum examination confirmed cervical ulceration, prompting the diagnosis of cervical carcinoma in both patients.
  • Malacoplakia of the female genital tract is documented rarely and remains unreported, to date, in AIDS patients.
  • Similar to the pathogenetic mechanisms described for AIDS-associated malacoplakia in extragenital sites, it is hypothesized that, in addition to abnormal macrophage functioning and an inability to degrade bacteria, special constituents of K. granulomatis are undigestable by lysosomal enzymes in human immunodeficiency virus-infected patients.
  • [MeSH-major] AIDS-Related Opportunistic Infections / virology. Acquired Immunodeficiency Syndrome / complications. Granuloma Inguinale / virology. Klebsiella Infections / virology. Malacoplakia / virology. Uterine Cervical Diseases / virology


62. Oliveira-Silva MB, Lages-Silva E, Resende DV, Prata A, Ramirez LE, Frenkel JK: Cystoisospora belli: in vitro multiplication in mammalian cells. Exp Parasitol; 2006 Nov;114(3):189-92
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  • Human ileocecal adenocarcinoma (HCT-8), epithelial carcinoma of lung (A549), Madin-Darby bovine kidney (MDBK), and African green monkey kidney (VERO) were exposed in vitro to C. belli sporozoites, which had been isolated from the feces of HIV-AIDS patients.
  • [MeSH-major] AIDS-Related Opportunistic Infections / parasitology. Coccidiosis / parasitology. Sarcocystidae / growth & development

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  • (PMID = 16674944.001).
  • [ISSN] 0014-4894
  • [Journal-full-title] Experimental parasitology
  • [ISO-abbreviation] Exp. Parasitol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Peters MG: Diagnosis and management of hepatitis B virus and HIV coinfection. Top HIV Med; 2007 Nov-Dec;15(5):163-6
HIV InSite. treatment guidelines - Coinfection with Hepatitis Viruses and HIV .

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  • HIV and hepatitis B virus (HBV) coinfection increases HIV and HBV replication, hepatitis flares, and risk of progression to chronic HBV infection, cirrhosis, and hepatocellular carcinoma.
  • HIV and HBV coinfection decreases frequency of hepatitis Be antibody (anti-HBe) and hepatitis B surface antibody (anti-HBs) seroconversion, increases risk of antiretroviral therapy-related hepatotoxicity, and reduces efficacy of HBV therapy.
  • Peters, MD, at an International AIDS Society-USA Continuing Medical Education course in San Francisco in May 2007.


64. Gormley RH, Kovarik CL: Dermatologic manifestations of HPV in HIV-infected individuals. Curr HIV/AIDS Rep; 2009 Aug;6(3):130-8
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  • Anogenital HPV-related disease includes benign condyloma acuminata, the most common cutaneous manifestation of genital HPV infection; intermediate malignancy or premalignant conditions including giant condyloma acuminata (also called Buschke-Loewenstein tumor), anal intraepithelial neoplasia, penile intraepithelial neoplasia, and vaginal or vulvar intraepithelial neoplasia; and frankly malignant disease including Bowen's disease and invasive anal, penile, or vulvar carcinoma.
  • Cutaneous HPV-related disease in nongenital skin is also increased in HIV-positive patients, in the form of benign common warts, epidermodysplasia verruciformis-like skin lesions, and nonmelanoma skin cancers.
  • [MeSH-minor] Antiretroviral Therapy, Highly Active. Carcinoma in Situ / etiology. Carcinoma in Situ / physiopathology. Humans. Papillomavirus Vaccines / therapeutic use. Skin Neoplasms / etiology. Skin Neoplasms / physiopathology

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  • (PMID = 19589298.001).
  • [ISSN] 1548-3576
  • [Journal-full-title] Current HIV/AIDS reports
  • [ISO-abbreviation] Curr HIV/AIDS Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Papillomavirus Vaccines
  • [Number-of-references] 69
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65. Epstein JB: Oral malignancies associated with HIV. J Can Dent Assoc; 2007 Dec;73(10):953-6
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  • HIV is associated with an increased risk of malignant disease that is related to immunosuppression and the activity of the HIV transactivator of transcription protein, coviral infection and exposure to carcinogens.
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / etiology. Humans. Immunosuppression / adverse effects. Lymphoma, AIDS-Related / diagnosis. Lymphoma, AIDS-Related / etiology. Sarcoma, Kaposi / diagnosis. Sarcoma, Kaposi / etiology. rev Gene Products, Human Immunodeficiency Virus / physiology

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  • (PMID = 18275699.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / rev Gene Products, Human Immunodeficiency Virus
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66. Suárez-Moreno RM, Hernández-Ramírez DA, Madrazo-Navarro M, Salazar-Lozano CR, García-Álvarez KG, Espinoza-Álvarez A: [Tuberculosis of the pancreas: an unsuspected cause of abdominal pain and fever]. Cir Cir; 2010 Jul-Aug;78(4):352-6
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • BACKGROUND: Tuberculosis is frequently the form of presentation of human immunodeficiency virus (HIV) infection even in patients who have not developed acquired immune deficiency syndrome (AIDS).
  • Tuberculosis of the pancreas (TBP) is a clinical rarity and mimics pancreatic carcinoma both clinically and radiologically.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. Abdominal Pain / etiology. Fever / etiology. Pancreatitis / diagnosis. Tuberculosis, Endocrine / diagnosis


67. Fox PA, Tung MY: Human papillomavirus: burden of illness and treatment cost considerations. Am J Clin Dermatol; 2005;6(6):365-81
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  • The duration of treatment is significantly related to the number of warts present, the area covered by the warts, and the length of time the warts have been present.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. AIDS-Related Opportunistic Infections / therapy. Antineoplastic Agents / economics. Antineoplastic Agents / therapeutic use. Carcinoma in Situ / therapy. Carcinoma in Situ / virology. Cryotherapy / economics. Electrosurgery / economics. Female. Humans. Keratolytic Agents / therapeutic use. Laser Therapy / economics. Neoplasms / therapy. Neoplasms / virology. Papillomaviridae. Pregnancy. Pregnancy Complications, Infectious / therapy. Viral Vaccines

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  • (PMID = 16343025.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Keratolytic Agents; 0 / Viral Vaccines
  • [Number-of-references] 136
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68. Siekas LL, Aboulafia DM: Establishing an anal dysplasia clinic for HIV-infected men: initial experience. AIDS Read; 2009 May;19(5):178-86
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  • Anal dysplasia caused by human papillomavirus (HPV) infection is common in the HIV-infected population and is a precursor to squamous cell carcinoma of the anus (SCCA).
  • We anticipate that the anal dysplasia clinic will enable our institution to participate in emerging HIV- and HPV-related AIN clinical trials.
  • [MeSH-major] Anus Neoplasms / etiology. Carcinoma in Situ / etiology. Carcinoma, Squamous Cell / etiology. HIV Infections / epidemiology. Precancerous Conditions / etiology

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  • [CommentIn] AIDS Read. 2009 May;19(5):182-3 [19554737.001]
  • (PMID = 19554736.001).
  • [ISSN] 1053-0894
  • [Journal-full-title] The AIDS reader
  • [ISO-abbreviation] AIDS Read
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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69. Sabbatani S, Fulgaro C, Latini G, Burzi M, Manfredi R: Associated actinomycosis and rhinopharyngeal adenocarcinoma during HIV infection: diagnostic and therapeutic issues. Infez Med; 2008 Sep;16(3):164-72
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • An extremely infrequent episode of nasopharyngeal actinomycosis associated with squamous adenocarcinoma occurred in an HIV-infected male patient with a previous diagnosis of AIDS, treated with combined antiretroviral therapy taken with insufficient adherence, such that a satisfactory immune system recovery (as expressed by a CD4 lymphocyte count persistently above 400 cells/mcl), contrasted with a low-level persistence of detectable HIV viraemia, and enlarged genotypic resistance mutations.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Acquired Immunodeficiency Syndrome / complications. Actinomycosis / complications. Carcinoma, Squamous Cell / complications. Nasopharyngeal Neoplasms / complications. Sinusitis / complications
  • [MeSH-minor] Administration, Inhalation. Anti-Bacterial Agents / therapeutic use. Antiretroviral Therapy, Highly Active. Brain Neoplasms / secondary. Cocaine-Related Disorders / complications. Combined Modality Therapy. Fatal Outcome. Heroin Dependence / complications. Humans. Male. Middle Aged. Patient Compliance. Smoking / adverse effects. Substance Abuse, Intravenous / complications. Tomography, X-Ray Computed


70. Butt FM, Chindia ML, Rana F, Machigo FG: Pattern of head and neck malignant neoplasms in HIV-infected patients in Kenya. Int J Oral Maxillofac Surg; 2008 Oct;37(10):907-11
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  • There is also an increased risk of oral squamous cell carcinoma (SCC).
  • [MeSH-minor] Adolescent. Adult. Age Factors. Burkitt Lymphoma / epidemiology. Candidiasis, Oral / epidemiology. Carcinoma, Squamous Cell / epidemiology. Cheilitis / epidemiology. Cross-Sectional Studies. Female. Humans. Kenya / epidemiology. Lymphoma, AIDS-Related / epidemiology. Male. Middle Aged. Mouth Neoplasms / epidemiology. Prevalence. Sarcoma, Kaposi / epidemiology. Sex Factors. Stomatitis, Aphthous / epidemiology. Young Adult


71. Silverberg MJ, Chao C, Leyden WA, Xu L, Tang B, Horberg MA, Klein D, Quesenberry CP Jr, Towner WJ, Abrams DI: HIV infection and the risk of cancers with and without a known infectious cause. AIDS; 2009 Nov 13;23(17):2337-45
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  • METHODS: Adult HIV-infected and matched HIV-uninfected members of Kaiser Permanente followed between 1996 and 2007 for incident AIDS-defining cancers (ADCs), infection-related non-AIDS-defining cancers (NADCs; anal squamous cell, vagina/vulva, Hodgkin's lymphoma, penis, liver, human papillomavirus-related oral cavity/pharynx, stomach) and infection-unrelated NADC (all other NADCs).
  • HIV-infected persons experienced 552 ADC, 221 infection-related NADC, and 388 infection-unrelated NADC.
  • HIV-uninfected persons experienced 179 ADC, 284 infection-related NADC, and 3418 infection-unrelated NADC.
  • The rate ratio for infection-related NADC was 9.2 (95% CI: 7.7-11.1), also with decreases in the rate ratio over time (P < 0.001).

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  • (PMID = 19741479.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / R01 AA016893; United States / NIAID NIH HHS / AI / K01 AI071725; United States / NIAID NIH HHS / AI / U01 AI069918-04; United States / NIAID NIH HHS / AI / K01 AI071725-03; United States / NIAID NIH HHS / AI / AI069918-04; United States / NIAID NIH HHS / AI / U01-AI069918; United States / NIAID NIH HHS / AI / K01AI071725; United States / NIAID NIH HHS / AI / AI071725-03; United States / NIAID NIH HHS / AI / U01 AI069918
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS198381; NLM/ PMC2863991
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72. Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, Su D, Sano M, Lytwyn A, Chapman W, Mahony J: Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology. Cancer Epidemiol Biomarkers Prev; 2009 Jul;18(7):1986-92
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • In the multivariable logistic regression model, HPV genotypes 16 [odds ratio, 2.58; 95% confidence interval (95% CI), 1.31-5.08; P = 0.006] and 31 (odds ratio, 4.74; 95% CI, 2.00-11.22; P = 0.0004), baseline CD4 count < 400 cells/mm(3) (odds ratio, 2.96; 95% CI, 1.46-5.99; P = 0.0025), and Acquired Immunodeficiency Syndrome (AIDS)-defining illness (odds ratio, 2.42; 95% CI, 1.22-4.82; P = 0.01) were associated with high-grade histology after adjusting for age.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Neoplasms / epidemiology. Carcinoma in Situ / epidemiology. Genes, p16. HIV Seropositivity / virology. Oncogene Proteins, Viral / genetics. Repressor Proteins / genetics
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. AIDS-Related Opportunistic Infections / virology. DNA, Viral / analysis. Genotype. Homosexuality, Male. Humans. Male. Papillomavirus Infections / complications. Papillomavirus Infections / epidemiology. Papillomavirus Infections / pathology. Papillomavirus Infections / virology. Risk Factors. Viral Load

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  • (PMID = 19567510.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / E6 protein, Human papillomavirus type 16; 0 / Oncogene Proteins, Viral; 0 / Repressor Proteins
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73. Biswas J, Sudharshan S: Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome. Indian J Ophthalmol; 2008 Sep-Oct;56(5):363-75
HIV InSite. treatment guidelines - Ophthalmic Manifestations of HIV .

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  • Cytomegalovirus (CMV) retinitis is the commonest ocular opportunistic infection seen in acquired immune deficiency syndrome (AIDS).
  • Effective antiretroviral therapy and improved prophylaxis and treatment of opportunistic infections have led to an increase in the survival of an individual afflicted with AIDS.
  • Common lesions include relatively benign conditions such as blepharitis and dry eye, to infections such as herpes zoster ophthalmicus and molluscum contagiosum and malignancies such as squamous cell carcinoma and Kaposi's sarcoma.
  • Several drugs used in the management of AIDS such as nevirapine or indinavir can themselves lead to severe inflammation in the anterior segment and adnexa of the eye.
  • [MeSH-major] AIDS-Related Opportunistic Infections. Anterior Eye Segment / virology. Uveitis, Anterior

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  • (PMID = 18711264.001).
  • [ISSN] 0301-4738
  • [Journal-full-title] Indian journal of ophthalmology
  • [ISO-abbreviation] Indian J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
  • [Number-of-references] 127
  • [Other-IDs] NLM/ PMC2636142
  •  go-up   go-down


74. Mannarini L, Kratochvil V, Calabrese L, Gomes Silva L, Morbini P, Betka J, Benazzo M: Human Papilloma Virus (HPV) in head and neck region: review of literature. Acta Otorhinolaryngol Ital; 2009 Jun;29(3):119-26
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The evidence that human papillomavirus infection is related to head and neck squamous cell carcinoma is supported by molecular and epidemiological data.
  • The definition of a distinct subset of head and neck squamous cell carcinoma, independent of the traditional risk factors and with different clinical presentation and outcome, has led to increasing interest in human papillomavirus infection.
  • [MeSH-minor] Carcinoma, Squamous Cell / virology. Humans. Mouth Neoplasms / virology. Oropharyngeal Neoplasms / virology

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  • (PMID = 20140157.001).
  • [ISSN] 1827-675X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 110
  • [Other-IDs] NLM/ PMC2815356
  • [Keywords] NOTNLM ; Head and neck / Human papillomavirus / Oral cavity / Oropharynx / Squamous cell carcinoma
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75. Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G: Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med; 2007 Jun 11;204(6):1441-51
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • While treating basal cell carcinoma (BCC) patients with topical IMQ, we detected, by immunohistochemistry, sizable numbers of both myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) within the inflammatory infiltrate.
  • Surprisingly, peritumoral mDCs stained positive for perforin and granzyme B, whereas infiltrating pDCs expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Carcinoma, Basal Cell / immunology. Dendritic Cells / immunology. Toll-Like Receptor 7 / metabolism. Toll-Like Receptor 8 / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Antibodies, Monoclonal. Cell Line, Tumor. Cytotoxicity Tests, Immunologic. Female. Flow Cytometry. Granzymes / immunology. Humans. Immunohistochemistry. Leukocytes / chemistry. Male. Perforin / immunology. TNF-Related Apoptosis-Inducing Ligand / immunology

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  • (PMID = 17535975.001).
  • [ISSN] 0022-1007
  • [Journal-full-title] The Journal of experimental medicine
  • [ISO-abbreviation] J. Exp. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / TLR7 protein, human; 0 / TLR8 protein, human; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFSF10 protein, human; 0 / Toll-Like Receptor 7; 0 / Toll-Like Receptor 8; 126465-35-8 / Perforin; 99011-02-6 / imiquimod; EC 3.4.21.- / Granzymes
  • [Other-IDs] NLM/ PMC2118597
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76. Saif MW, Kaley K, Lamb L, Pecerillo J, Hotchkiss S, Steven L, Brennan M, Penney R, Gillespie C, Shaib W: Management of skin toxicities of anti-EGFR agents in patients with pancreatic cancer and other GI tumors by using electronic communication: effective and convenient. JOP; 2010;11(2):176-82
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

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  • We suggest that electronic communication is of crucial importance to detect early, diagnose and treat anti-EGFR related skin rash in order to continue the benefit of anti-EGFR.
  • [MeSH-major] Carcinoma / drug therapy. Electronic Mail. Gastrointestinal Neoplasms / drug therapy. Pancreatic Neoplasms / drug therapy. Protein Kinase Inhibitors / adverse effects. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Skin Diseases / chemically induced. Skin Diseases / therapy. Telecommunications
  • [MeSH-minor] Adverse Drug Reaction Reporting Systems. Algorithms. Audiovisual Aids. Communication. Continuity of Patient Care. Drug-Related Side Effects and Adverse Reactions / therapy. Efficiency. Health Services Accessibility. Humans. Patient Compliance. Physician-Patient Relations

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  • (PMID = 20208331.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Lectures
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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77. Crum-Cianflone N, Hullsiek KH, Satter E, Marconi V, Weintrob A, Ganesan A, Barthel RV, Fraser S, Agan BK: Cutaneous malignancies among HIV-infected persons. Arch Intern Med; 2009 Jun 22;169(12):1130-8
HIV InSite. treatment guidelines - Human Herpesvirus-8 .

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  • Since the advent of highly active antiretroviral therapy (HAART), the incidence rates of cutaneous non-AIDS-defining cancers (NADCs), in particular basal cell carcinoma, have exceeded the rates of cutaneous AIDS-defining cancers such as Kaposi sarcoma.
  • Cutaneous NADCs do not appear to be significantly associated with immune function or HAART but rather are related to traditional factors such as aging and skin color.

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  • (PMID = 19546414.001).
  • [ISSN] 1538-3679
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / HU0001-05-2-0011; United States / PHS HHS / / HU0001-05-2-0011
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Other-IDs] NLM/ NIHMS127594; NLM/ PMC2761839
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78. Chuka-Okosa CM, Uche NJ, Kizor-Akaraiwe NN: Orbito-ocular neoplasms in Enugu, South-Eastern, Nigeria. West Afr J Med; 2008 Jul;27(3):144-7
HIV InSite. treatment guidelines - Ophthalmic Manifestations of HIV .

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  • In this era of HIV pandemic, an increase in the frequency of AIDS-related orbito-ocular neoplasms has also been reported.
  • Retinoblastoma was the most commonly occurring neoplasm accounting for 25.6% of all the tumours; followed by squamous cell carcinoma of the conjunctiva which was seen in 5 (11.6%) of cases.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / pathology. Child. Child, Preschool. Female. Hospitals, Teaching / statistics & numerical data. Humans. Infant. Male. Middle Aged. Nigeria / epidemiology. Retinoblastoma / epidemiology. Retinoblastoma / pathology. Retrospective Studies. Sex Distribution. Young Adult

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  • (PMID = 19256317.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Nigeria
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79. Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA: The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. Int J STD AIDS; 2007 Feb;18(2):77-80
MedlinePlus Health Information. consumer health - HIV/AIDS.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma, Squamous Cell. HIV Infections / complications. Homosexuality, Male
  • [MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / epidemiology. Adult. Aged. Biopsy. Cytological Techniques. Humans. Male. Middle Aged. Predictive Value of Tests. Prevalence

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  • (PMID = 17331275.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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80. Frezzini C, Leao JC, Porter S: Current trends of HIV disease of the mouth. J Oral Pathol Med; 2005 Oct;34(9):513-31
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  • There is now considerable understanding of the molecular epidemiology, transmission and therapy of the common opportunistic oral infections of HIV disease, and as a consequence of improved anti-HIV strategies, the frequency and severity of oral disease associated with HIV infection have reduced considerably, although HAART may predispose to human papilloma virus infection of the mouth and potentially increase the risk of later oral squamous cell carcinoma.
  • [MeSH-major] AIDS-Related Opportunistic Infections / etiology. HIV Infections / complications. Mouth Diseases / etiology

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  • (PMID = 16138890.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 261
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81. Panos GZ, Karydis I, Velakoulis SE, Falagas ME: Multi-skeletal Pneumocystis jiroveci (carinii) in an HIV-seropositive patient. Int J STD AIDS; 2007 Feb;18(2):134-7
COS Scholar Universe. author profiles.

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  • Cytological examination of sputum specimens showed findings consistent with non-small-cell lung carcinoma.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / microbiology. AIDS-Related Opportunistic Infections / radiography. Brain Diseases / microbiology. Brain Diseases / radiography. HIV Infections / complications. Humans. Male. Middle Aged
  • <