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1. Pineda CE, Welton ML: Management of anal squamous intraepithelial lesions. Clin Colon Rectal Surg; 2009 May;22(2):94-101
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  • The disease is increasing in both incidence and prevalence, especially among patients with the following risk factors: homosexual men, acquired or iatrogenic immunosuppression, and presence of other HPV-related diseases.
  • Although the natural history of the disease is unknown, there is significant evidence that untreated HSIL progresses to squamous cell carcinoma in 11% of patients and in up to 50% of patients with extensive disease and immunosuppression.

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  • (PMID = 20436833.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780238
  • [Keywords] NOTNLM ; Anal squamous dysplasia / high-grade squamous intraepithelial lesions / high-resolution anoscopy
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2. Heyns CF, Groeneveld AE, Sigarroa NB: Urologic complications of HIV and AIDS. Nat Clin Pract Urol; 2009 Jan;6(1):32-43
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  • [Title] Urologic complications of HIV and AIDS.
  • Disease progression from HIV to AIDS and HIV-related mortality can be reduced effectively by several years of treatment with highly active antiretroviral therapy (HAART).
  • For patients who do not have access to HAART, HIV infection continues to be a lethal disorder characterized by opportunistic infection with uncommon organisms (e.g. mycobacteria, fungi, parasites and viruses), as well as lethal malignancies such as Kaposi sarcoma, non-Hodgkin lymphoma and squamous cell carcinoma of the penis or cervix.

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  • [ErratumIn] Nat Clin Pract Urol. 2010 Apr;7(4):178
  • (PMID = 19132004.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 134
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3. Heneghan MK, Hazan C, Halpern AC, Oliveria SA: Skin cancer coverage in a national newspaper: a teachable moment. J Cancer Educ; 2007;22(2):99-104
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  • BACKGROUND: The objectives of this study were to (1) identify the number of published articles related to skin cancer in The New York Times newspaper from 1980-2004;.
  • (2) assess the content of the articles related to skin cancer, and (3) examine the trends in media coverage of skin cancer over time.
  • METHODS: We performed a content analysis on articles related to skin cancer appearing in The New York Times during January 1, 1980, through December 31, 2004, using the ProQuest online content repository database and key words skin cancer.
  • We conducted an advanced focus search of all "skin cancer" articles using key words "melanoma," "squamous cell carcinoma," "basal cell carcinoma," "sunscreen," "tanning," "sunbathing," and "tanning salon".
  • Coverage of other major subjects included sunscreen (11%), tanning (9%), basal cell carcinoma (7%), squamous cell carcinoma (3%), sunbathing (2%), and tanning salon (2%).
  • Over the 25-year period we examined, there was a slight upward trend in the number of skin-cancer-related articles, although we observed year-to-year variation.

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  • (PMID = 17605623.001).
  • [ISSN] 0885-8195
  • [Journal-full-title] Journal of cancer education : the official journal of the American Association for Cancer Education
  • [ISO-abbreviation] J Cancer Educ
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / K07 CA94002
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
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4. Kumwenda JJ, Nyirenda M, Tomoka T, Ricken D, Chalulu K, Kamiza S: Case report-right iliac fossa mass in an HIV-positive woman. Cryptococcal meningitis. Malawi Med J; 2010 Jun;22(2):57-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. HIV Seropositivity / complications. Lymphatic Diseases / complications. Meningitis, Cryptococcal / virology
  • [MeSH-minor] Adult. Anti-HIV Agents / adverse effects. CD4 Lymphocyte Count. Carcinoma / pathology. Carcinoma / surgery. Colectomy. Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Cryptococcus neoformans / isolation & purification. Diagnosis, Differential. Fatal Outcome. Female. HIV-1. Humans


5. Sahali S, Bichet JC, Delfraissy JF, Ghosn J: Breast enlargement in an HIV-infected man on combined antiretroviral therapy: what if it was carcinoma? Int J STD AIDS; 2010 May;21(5):373-4
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  • [Title] Breast enlargement in an HIV-infected man on combined antiretroviral therapy: what if it was carcinoma?
  • We describe a case of an HIV-infected man on effective combined antiretroviral therapy, presenting with bilateral gynaecomastia revealing breast carcinoma.
  • Gynaecomastia was first considered to be related to efavirenz and/or didanosine.
  • Although breast carcinoma is rare among HIV-infected men, it should be considered as a potential cause of breast enlargement.
  • [MeSH-major] Breast Neoplasms, Male / diagnosis. Carcinoma, Intraductal, Noninfiltrating / diagnosis. Gynecomastia / etiology. HIV Infections / drug therapy. Reverse Transcriptase Inhibitors / adverse effects

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  • (PMID = 20498112.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Benzoxazines; 0 / Reverse Transcriptase Inhibitors; 2T8Q726O95 / Lamivudine; JE6H2O27P8 / efavirenz; K3GDH6OH08 / Didanosine
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6. Berretta M, Zanet E, Di Benedetto F, Simonelli C, Bearz A, Morra A, Bonanno S, Berretta S, Tirelli U: Unusual presentation of metastatic hepatocellular carcinoma in an HIV/HCV coinfected patient: case report and review of the literature. Tumori; 2008 Jul-Aug;94(4):589-91
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  • [Title] Unusual presentation of metastatic hepatocellular carcinoma in an HIV/HCV coinfected patient: case report and review of the literature.
  • Hepatocellular carcinoma (HCC) is an increasing cause of mortality in human immunodeficiency virus (HIV) seropositive patients.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Carcinoma, Hepatocellular / diagnosis. Hepatitis C / complications. Liver Neoplasms / diagnosis


7. Haigentz M Jr: Aerodigestive cancers in HIV infection. Curr Opin Oncol; 2005 Sep;17(5):474-8
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  • Given the improvements in life expectancy of persons with HIV/AIDS when treated with highly active antiretroviral agents, persons with HIV infection are therefore increasingly likely to develop these malignancies.
  • Although these neoplasms are non-AIDS defining, factors that might contribute to risk include HIV-related immunosuppression and co-infection with high-risk human papillomavirus subtypes.
  • [MeSH-major] Carcinoma, Squamous Cell. HIV Infections / complications. Head and Neck Neoplasms. Lung Neoplasms


8. Fan X, Scott L, Qiu S, Raju GS, Shabot M: Colonic coinfection of histoplasma and cytomegalovirus mimicking carcinoma in a patient with HIV/AIDS. Gastrointest Endosc; 2008 May;67(6):977-8; discussion 978
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  • [Title] Colonic coinfection of histoplasma and cytomegalovirus mimicking carcinoma in a patient with HIV/AIDS.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. Carcinoma / diagnosis. Colitis / diagnosis. Colonic Neoplasms / diagnosis. Cytomegalovirus Infections / diagnosis. Histoplasmosis / diagnosis


9. Handisurya A, Rieger A, Bankier A, Koller A, Salat A, Stingl G, Kirnbauer R: Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy. Br J Dermatol; 2007 Oct;157(4):788-94
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  • [Title] Human papillomavirus type 26 infection causing multiple invasive squamous cell carcinomas of the fingernails in an AIDS patient under highly active antiretroviral therapy.
  • Squamous cell carcinoma (SCC) of the nail unit is a rare disorder.
  • [MeSH-major] AIDS-Related Opportunistic Infections / complications. Alphapapillomavirus / classification. Carcinoma, Squamous Cell / virology. Nails. Papillomavirus Infections / complications. Skin Neoplasms / virology

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  • (PMID = 17634082.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Grant] Austria / Austrian Science Fund FWF / / P 18990
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ EMS55131; NLM/ PMC3935457
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10. De Giorgi V, Monaco A, Worchech A, Tornesello M, Izzo F, Buonaguro L, Marincola FM, Wang E, Buonaguro FM: Gene profiling, biomarkers and pathways characterizing HCV-related hepatocellular carcinoma. J Transl Med; 2009;7:85
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  • [Title] Gene profiling, biomarkers and pathways characterizing HCV-related hepatocellular carcinoma.
  • BACKGROUND: Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) worldwide.
  • Samples were obtained from 14 patients affected by HCV-related HCC and 7 HCV-negative non-liver-cancer patients, enrolled at INT in Naples.
  • RESULTS: Significant differences were found between the expression patterns of several genes falling into different metabolic and inflammation/immunity pathways in HCV-related HCC tissues as well as the non-HCC counterpart compared to normal liver tissues.
  • Only few genes were found differentially expressed between HCV-related HCC tissues and paired non-HCC counterpart.
  • CONCLUSION: In this study, informative data on the global gene expression pattern of HCV-related HCC and non-HCC counterpart, as well as on their difference with the one observed in normal liver tissues have been obtained.
  • These results may lead to the identification of specific biomarkers relevant to develop tools for detection, diagnosis, and classification of HCV-related HCC.
  • [MeSH-major] Biomarkers. Carcinoma, Hepatocellular. Gene Expression Profiling. Hepacivirus / genetics. Hepatitis C / genetics. Liver Neoplasms

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  • (PMID = 19821982.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers
  • [Other-IDs] NLM/ PMC2768694
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11. Bray J, Sludden J, Griffin MJ, Cole M, Verrill M, Jamieson D, Boddy AV: Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer; 2010 Mar 16;102(6):1003-9
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  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Carcinoma, Ductal, Breast / drug therapy. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Pharmacogenetics
  • [MeSH-minor] Aryl Hydrocarbon Hydroxylases / genetics. Biomarkers, Pharmacological / analysis. Biomarkers, Tumor / genetics. Cytochrome P-450 CYP2B6. Drug Resistance, Neoplasm / genetics. Drug-Related Side Effects and Adverse Reactions / genetics. Female. Gene Frequency. Genotype. Humans. Middle Aged. Organic Cation Transport Proteins / genetics. Oxidoreductases, N-Demethylating / genetics. P-Glycoprotein / genetics. P-Glycoproteins. Polymorphism, Single Nucleotide. Retrospective Studies. Survival Analysis

  • Genetic Alliance. consumer health - Breast Cancer.
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  • (PMID = 20179710.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ABCB1 protein, human; 0 / Biomarkers, Pharmacological; 0 / Biomarkers, Tumor; 0 / Organic Cation Transport Proteins; 0 / P-Glycoprotein; 0 / P-Glycoproteins; 0 / SLC22A16 protein, human; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; EC 1.14.14.1 / Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1 / CYP2B6 protein, human; EC 1.14.14.1 / Cytochrome P-450 CYP2B6; EC 1.5.- / Oxidoreductases, N-Demethylating
  • [Other-IDs] NLM/ PMC2844036
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12. Chang CM, Yu KJ, Mbulaiteye SM, Hildesheim A, Bhatia K: The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: a need for reappraisal. Virus Res; 2009 Aug;143(2):209-21
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  • Epstein-Barr virus (EBV) is a ubiquitous, gamma-1 lymphotrophic virus etiologically linked to nasopharyngeal carcinoma (NPC), endemic to Southern China, and Burkitt lymphoma (BL), endemic to equatorial Africa, both of which are rare elsewhere in the world.
  • Why EBV is associated with different malignancies in different geographic regions remains puzzling and may be related to EBV genotypic variability through specific disease and geographic associations.
  • [MeSH-minor] Africa / epidemiology. Burkitt Lymphoma / epidemiology. Burkitt Lymphoma / virology. Carcinoma / epidemiology. Carcinoma / virology. China / epidemiology. Epstein-Barr Virus Nuclear Antigens / genetics. Genotype. Geography. Humans. Nasopharyngeal Neoplasms / epidemiology. Nasopharyngeal Neoplasms / virology. Trans-Activators / genetics. Viral Matrix Proteins / genetics

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  • (PMID = 19596032.001).
  • [ISSN] 1872-7492
  • [Journal-full-title] Virus research
  • [ISO-abbreviation] Virus Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / BZLF1 protein, Herpesvirus 4, Human; 0 / EBV-associated membrane antigen, Epstein-Barr virus; 0 / EBV-encoded nuclear antigen 1; 0 / Epstein-Barr Virus Nuclear Antigens; 0 / Trans-Activators; 0 / Viral Matrix Proteins
  • [Number-of-references] 160
  • [Other-IDs] NLM/ NIHMS132135; NLM/ PMC2731007
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13. Suárez-Moreno RM, Hernández-Ramírez DA, Madrazo-Navarro M, Salazar-Lozano CR, García-Álvarez KG, Espinoza-Álvarez A: [Tuberculosis of the pancreas: an unsuspected cause of abdominal pain and fever]. Cir Cir; 2010 Jul-Aug;78(4):352-6
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  • BACKGROUND: Tuberculosis is frequently the form of presentation of human immunodeficiency virus (HIV) infection even in patients who have not developed acquired immune deficiency syndrome (AIDS).
  • Tuberculosis of the pancreas (TBP) is a clinical rarity and mimics pancreatic carcinoma both clinically and radiologically.
  • [MeSH-major] AIDS-Related Opportunistic Infections / diagnosis. Abdominal Pain / etiology. Fever / etiology. Pancreatitis / diagnosis. Tuberculosis, Endocrine / diagnosis


14. Licci S, Brenna A, Abbate I, Ascani S: The association between non-Hodgkin lymphoma and renal cell carcinoma in an HIV-positive patient: clinico-pathological features and pathogenic implications. Am J Hematol; 2008 Sep;83(9):759
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  • [Title] The association between non-Hodgkin lymphoma and renal cell carcinoma in an HIV-positive patient: clinico-pathological features and pathogenic implications.
  • [MeSH-major] Carcinoma, Renal Cell / etiology. Epstein-Barr Virus Infections / complications. HIV Infections / complications. Kidney Neoplasms / etiology. Lymphoma, AIDS-Related / etiology. Lymphoma, Large B-Cell, Diffuse / etiology. Neoplasms, Multiple Primary / etiology


15. Guiltinan AM, Kaidarova Z, Custer B, Orland J, Strollo A, Cyrus S, Busch MP, Murphy EL: Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors. Am J Epidemiol; 2008 Mar 15;167(6):743-50
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  • Hospital-based studies suggest that hepatitis C virus (HCV) infection causes frequent cirrhosis, hepatocellular carcinoma, and mortality, but epidemiologic studies have shown less morbidity and mortality.
  • Excess mortality in the HCV+ group was greatest in liver-related (HR = 45.99, 95% CI: 11.32, 186.74), drug- or alcohol-related (HR = 10.81, 95% CI: 4.68, 24.96), and trauma/suicide (HR = 2.99, 95% CI: 2.05, 4.36) causes.

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  • (PMID = 18203734.001).
  • [ISSN] 1476-6256
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] ENG
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL076902-04; United States / NHLBI NIH HHS / HL / K24 HL075036; United States / NHLBI NIH HHS / HL / R01-HL-076902; United States / NHLBI NIH HHS / HL / K24-HL-75036; United States / NHLBI NIH HHS / HL / R01 HL076902; United States / NHLBI NIH HHS / HL / K24 HL075036-04; United States / NHLBI NIH HHS / HL / HL076902-04; United States / NHLBI NIH HHS / HL / HL075036-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS180412; NLM/ PMC2858006
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16. Campisi G, Giovannelli L: Controversies surrounding human papilloma virus infection, head & neck vs oral cancer, implications for prophylaxis and treatment. Head Neck Oncol; 2009;1:8
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  • Because of the attention and clamor surrounding oral HPV infection and related cancers, as well as the use of HPV prophylactic vaccines, in this invited perspective the authors raise some questions and review some controversial issues on HPV infection and its role in HNC, with a particular focus on oral squamous cell carcinoma.
  • The problematic definition and classification of HNC will be discussed, together with the characteristics of oral infection with oncogenic HPV types, the frequency of HPV DNA detection in HNC, the location of HPV-related tumours, the severity and prognosis of HPV-positive HNC, the diagnosis of oral HPV infection, common routes of oral infection and the likelihood of oro-genital HPV transmission, the prevention of HPV infection and novel therapeutic approaches.

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  • (PMID = 19331691.001).
  • [ISSN] 1758-3284
  • [Journal-full-title] Head & neck oncology
  • [ISO-abbreviation] Head Neck Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Papillomavirus Vaccines
  • [Other-IDs] NLM/ PMC2673223
  • [General-notes] NLM/ Original DateCompleted: 20100629
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17. Rosenthal E, Salmon-Céron D, Lewden C, Bouteloup V, Pialoux G, Bonnet F, Karmochkine M, May T, François M, Burty C, Jougla E, Costagliola D, Morlat P, Chêne G, Cacoub P, Mortavic/Mortalité 2005 Study Group: Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 study in collaboration with the Mortalité 2005 survey, ANRS EN19). HIV Med; 2009 May;10(5):282-9
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  • [Title] Liver-related deaths in HIV-infected patients between 1995 and 2005 in the French GERMIVIC Joint Study Group Network (Mortavic 2005 study in collaboration with the Mortalité 2005 survey, ANRS EN19).
  • Results Among 287 reported deaths in 2005, 100 (35%) were related to AIDS, and 48 (17%) to ESLD.
  • Three out of four patients who died from ESLD-related causes had chronic hepatitis C.
  • The proportion of deaths caused by hepatocellular carcinoma increased from 5% in 1995 to 25% in 2005 (P=0.0337).
  • CONCLUSIONS: Over the 10 years from 1995 to 2005, the proportion of deaths caused by hepatitis C virus-related ESLD has increased in HIV-infected patients.
  • ESLD is currently a leading cause of death in this population, with hepatocellular carcinoma representing a quarter of liver-related deaths.
  • Recommendations for the detection of hepatocellular carcinoma should be strictly applied in these patients.
  • [MeSH-major] Carcinoma, Hepatocellular / mortality. HIV Infections / mortality. Hepatitis C, Chronic / mortality. Liver Neoplasms / mortality

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  • (PMID = 19226410.001).
  • [ISSN] 1468-1293
  • [Journal-full-title] HIV medicine
  • [ISO-abbreviation] HIV Med.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / alpha-Fetoproteins
  • [Investigator] Pautard-Huchemblé B; Schmit JL; Bonnefoy M; Bru JP; Gaillat J; Lerousseau L; Dubois D; Azzedine A; De La Blanchardière A; Lepeu G; Faller JP; Balvay P; Barale F; Estavoyer JM; Vuitton D; Bentata M; Cohen P; Guillevin L; Jarrousse B; Padrazzi B; Beylot J; Bernard N; Constans J; Loury I; Moreau F; Morlat P; Ragnaud JM; Viaud JF; Lacoste D; Baglin A; Dorra M; Dupont C; Hanslik T; Rouveix E; Granier P; Cénac A; Bazin C; Hazera P; Verdon R; Schmidt J; Rogeaux O; Menalba C; Boué F; Fior R; Galanaud P; Pik JJ; Beytout J; Laurichesse H; Ruivard M; Laplatte G; Audoy B; Plaisance N; Bouterra C; Laylotte G; Delarocque E; Vinceneux P; Lesprit P; Schaeffer A; Grappin M; Greuzard MC; Loudes-Chauvin MC; Portier H; Vinceneux M; Guillaumie J; Dournovo P; De Truchis P; Perronne C; Bouchard O; Micoud M; Morand P; Boucher J; Chambourlier P; Renou C; Arvin-Berod C; Poubeau P; Perre P; Hachulla E; Devulder B; Hatron PY; Loustaud-Ratti V; Berthou JD; Baborier D; Constant E; Dufay E; Peyramond D; Trémolières F; Bourgeade A; Durand JM; Gastaut JA; Gallais H; Moreau J; Perret JL; Poizot-Martin I; Soubeyrand J; Meissonnier P; Hayek R; Constant C; Raabe JJ; Wang A; Astruc J; Blanc F; Perney P; Vandôme A; Bautoille D; Guerbois C; Loyau C; Raffi F; Villers D; Burty C; Canton P; de Korwin JD; Thibaut G; Wahl D; Dellamonica P; Cassuto JP; Ceppi C; Fuzibet JG; Poirée M; Pradier C; Rosenthal E; Raffanel C; Amoura Z; Aumaitre H; Bani-Sadr F; Bergmann JF; Bissuel F; Boissonnas A; Bouvet E; Bricaire F; Cabane J; Cabié A; Cacoub P; Caquet R; Carbon C; Caulin C; Chemlal K; Coulaud JP; de Beaumont T; Devars du Mayne F; Dupont C; Durand B; Farge D; Galanaud P; Gaudebout C; Gilquin J; Goujard C; Hausfater P; Katlama C; Karmochkine M; Krainik F; Le Bras P; Le Moing V; Leport C; Modaï J; Molina JM; Pialoux G; Piette JC; Poinsignon Y; Quertainmont Y; Raguin G; Rozenbaum W; Sicard D; Simon J; Vachon F; Valleron AJ; Vildé JL; Arsac P; Calamy G; Mille C; Mercie P; Pellegrin JL; Becq-Giraudon B B; Breux JP; Le Moal G; Michelet C; Cartier F; Beguinot I; Rémy G; Gueit I; Borsa-Lebas F; Humbert G; Wemeau J; Hascouet C; Le Cam B; Khuong MA; Mechali D; Roblin X; Defontaine C; Lucht F; Fégueux S; Veyssier-Belot C; Ouzan D; Kitschke B; Clément-Bertoldo C; Gonzales G; Poubeau P; Fischer P; Lang JM; Rey D; Ruellan A; Schlienger JL; Zucman D; Blétry O; Romand P; Alric L; Cuzin L; Duffaut M; Ajana F; Mouton Y; Yazdanpanah Y; Borderon JC; Choutet P; Guimard Y; Patey O
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18. Merchante N, Jiménez-Saenz M, Pineda JA: Management of HCV-related end-stage liver disease in HIV-coinfected patients. AIDS Rev; 2007 Jul-Sep;9(3):131-9
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  • [Title] Management of HCV-related end-stage liver disease in HIV-coinfected patients.
  • Ascites and hepatic encephalopathy are much more frequent, whereas hepatocellular carcinoma is still uncommon, when simultaneous hepatitis B virus infection is absent.
  • [MeSH-minor] Ascites / etiology. Ascites / therapy. Carcinoma, Hepatocellular / complications. Carcinoma, Hepatocellular / virology. Disease Progression. Hepatic Encephalopathy / etiology. Hepatic Encephalopathy / therapy. Hepatitis B / complications. Hepatorenal Syndrome / etiology. Hepatorenal Syndrome / therapy. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / etiology. Liver Neoplasms / therapy. Liver Transplantation. Peritonitis / drug therapy. Peritonitis / prevention & control


19. Alter MJ: Epidemiology of hepatitis C virus infection. World J Gastroenterol; 2007 May 7;13(17):2436-41
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  • HCV-infected people serve as a reservoir for transmission to others and are at risk for developing chronic liver disease, cirrhosis, and primary hepatocellular carcinoma (HCC).
  • However, the wave of increased HCV-related morbidity and mortality that we are now facing is the result of an unprecedented increase in the spread of HCV during the 20th century.

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  • (PMID = 17552026.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 63
  • [Other-IDs] NLM/ PMC4146761
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20. Pascual D, Borque A: Epidemiology of kidney cancer. Adv Urol; 2008;:782381
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  • Some tumors are known to have a definite cause-effect etiology, but renal cell carcinoma (RCC) is not one of them precisely.
  • With regard to RCC we can only try to identify some clinical and occupational factors as well as substances related to tumorigenesis.
  • The aim of this review is to summarize the well-defined causes of renal cell carcinoma.

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  • (PMID = 19009036.001).
  • [ISSN] 1687-6369
  • [Journal-full-title] Advances in urology
  • [ISO-abbreviation] Adv Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2581742
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21. Epstein JB: Oral malignancies associated with HIV. J Can Dent Assoc; 2007 Dec;73(10):953-6
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  • HIV is associated with an increased risk of malignant disease that is related to immunosuppression and the activity of the HIV transactivator of transcription protein, coviral infection and exposure to carcinogens.
  • [MeSH-minor] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / etiology. Humans. Immunosuppression / adverse effects. Lymphoma, AIDS-Related / diagnosis. Lymphoma, AIDS-Related / etiology. Sarcoma, Kaposi / diagnosis. Sarcoma, Kaposi / etiology. rev Gene Products, Human Immunodeficiency Virus / physiology

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  • (PMID = 18275699.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / rev Gene Products, Human Immunodeficiency Virus
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22. Ukponmwan CU, Egbagbe EE, Osahon AI: Prevalence of human immunodeficiency virus in ophthalmic surgical patients. Niger J Clin Pract; 2009 Jun;12(2):120-3
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  • The 25 year old female presented with squamous cell carcinoma of the conjunctiva, while the 57 year old woman had panophthalmitis.
  • HIV screening should be mandatory for high risk patients such as those with panophthalmitis, herpes zoster and squamous cell carcinoma of the conjunctiva that are markers for HIV.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / epidemiology. Adolescent. Adult. Aged. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Prevalence. Prospective Studies. Young Adult

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  • (PMID = 19764656.001).
  • [ISSN] 1119-3077
  • [Journal-full-title] Nigerian journal of clinical practice
  • [ISO-abbreviation] Niger J Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Nigeria
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23. Ye ZB, Ma T, Li H, Jin XL, Xu HM: Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma. World J Gastroenterol; 2007 Mar 21;13(11):1747-51
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  • [Title] Expression and significance of intratumoral interleukin-12 and interleukin-18 in human gastric carcinoma.
  • AIM: To explore the effect of intratumoral expressions of interleukin-12 (IL-12) and interleukin-18 (IL-18) on clinical features, angiogenesis and prognosis of gastric carcinoma.
  • IL-12 was significantly associated with pathologic differentiation, depth of invasion, lymph node metastasis, distant metastasis, and TNM stage, and IL-18 was closely related to distant metastasis.
  • Intratumoral IL-12 and IL-18 expressions were not statistically related to MVD scoring.
  • CONCLUSION: The positive expressions of IL-12 and IL-18 can play an important role in progression and metastasis of gastric cancer, and IL-12 might be an independent factor of poor prognosis in gastric carcinoma.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma, Mucinous / metabolism. Carcinoma, Signet Ring Cell / metabolism. Interleukin-12 / metabolism. Interleukin-18 / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 17461482.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Interleukin-18; 187348-17-0 / Interleukin-12
  • [Other-IDs] NLM/ PMC4146958
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24. Shiboski CH, Patton LL, Webster-Cyriaque JY, Greenspan D, Traboulsi RS, Ghannoum M, Jurevic R, Phelan JA, Reznik D, Greenspan JS, Oral HIV/AIDS Research Alliance, Subcommittee of the AIDS Clinical Trial Group: The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints. J Oral Pathol Med; 2009 Jul;38(6):481-8
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  • [Title] The Oral HIV/AIDS Research Alliance: updated case definitions of oral disease endpoints.
  • The Oral HIV/AIDS Research Alliance (OHARA) is part of the AIDS Clinical Trials Group (ACTG), the largest HIV clinical trials organization in the world.
  • Its main objective is to investigate oral complications associated with HIV/AIDS as the epidemic is evolving, in particular, the effects of antiretrovirals on oral mucosal lesion development and associated fungal and viral pathogens.
  • Many studies have shared end-points, which include oral diseases known to be associated with HIV/AIDS measured by trained and calibrated ACTG study nurses.
  • The objective of this article is to present updated case definitions for HIV-related oral diseases that will be used to measure standardized clinical end-points in OHARA studies, and that can be used by any investigator outside of OHARA/ACTG conducting clinical research that pertains to these end-points.

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  • (PMID = 19594839.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / U01 AI068636; United States / NIAID NIH HHS / AI / U01 AI 68636
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
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25. Dubina M, Goldenberg G: Viral-associated nonmelanoma skin cancers: a review. Am J Dermatopathol; 2009 Aug;31(6):561-73
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  • Several types of nonmelanoma skin cancer and precancerous lesions have an associated viral pathogenesis, including epidermodysplasia verruciformis, verrucous carcinoma, bowenoid papulosis, Kaposi sarcoma, squamous cell carcinoma, and, most recently, Merkel cell carcinoma.
  • They can be divided into genera including alpha, beta, and gamma HPVs, which comprise the majority of cutaneous HPvs. The relationship between viruses and cancer is a popular focus of research in an era of AIDS and organ transplantation, where immunosuppression is not uncommon.
  • The incidence of viral-related malignancies in these populations is increasing.

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  • [CommentIn] Am J Dermatopathol. 2010 Jul;32(5):522 [20571349.001]
  • (PMID = 19590418.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 195
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26. Mani D, Guinee DG Jr, Aboulafia DM: AIDS-associated plasmablastic lymphoma presenting as a poorly differentiated esophageal tumor: a diagnostic dilemma. World J Gastroenterol; 2008 Jul 21;14(27):4395-9
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  • [Title] AIDS-associated plasmablastic lymphoma presenting as a poorly differentiated esophageal tumor: a diagnostic dilemma.
  • Herein we describe a patient with AIDS who presented with weight loss and dysphagia owing to a large gastroesophageal mass.
  • His radiographic and endoscopic findings and long history of cigarette consumption suggested carcinoma.
  • [MeSH-major] Esophageal Neoplasms / complications. Esophageal Neoplasms / diagnosis. Lymphoma, AIDS-Related / diagnosis. Medical Oncology / methods. Plasma Cells / pathology

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  • (PMID = 18666332.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; EC 3.2.2.5 / Antigens, CD38
  • [Other-IDs] NLM/ PMC2731195
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27. Clements CJ, Coghlan B, Creati M, Locarnini S, Tedder RS, Torresi J: Global control of hepatitis B virus: does treatment-induced antigenic change affect immunization? Bull World Health Organ; 2010 Jan;88(1):66-73
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  • The vaccine has been particularly important for countries where the incidence of hepatitis B virus-related hepatocellular carcinoma is high.

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  • (PMID = 20428355.001).
  • [ISSN] 1564-0604
  • [Journal-full-title] Bulletin of the World Health Organization
  • [ISO-abbreviation] Bull. World Health Organ.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral; 0 / Hepatitis B Surface Antigens; 0 / Hepatitis B Vaccines
  • [Other-IDs] NLM/ PMC2802438
  •  go-up   go-down


28. Holkar S, Mudhar HS, Jain A, Gupta M, Rogstad KE, Parsons MA, Singh AD, Rennie IG: Regression of invasive conjunctival squamous carcinoma in an HIV-positive patient on antiretroviral therapy. Int J STD AIDS; 2005 Dec;16(12):782-3
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  • [Title] Regression of invasive conjunctival squamous carcinoma in an HIV-positive patient on antiretroviral therapy.
  • A conjunctival biopsy revealed invasive squamous cell carcinoma, with orbital invasion on computed tomography scan.
  • Discussion covers conjunctival carcinoma and behaviour of HIV-related tumours with antiretroviral therapy.
  • [MeSH-major] Antiretroviral Therapy, Highly Active / adverse effects. Carcinoma, Squamous Cell / etiology. Conjunctival Neoplasms / etiology. HIV Infections / complications


29. McMahon BJ: The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B. Hepatol Int; 2009 Jun;3(2):334-42
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  • BACKGROUND: Chronic infection with hepatitis B virus (HBV) is associated with a high lifetime risk of developing hepatocellular carcinoma (HCC) and cirrhosis of the liver.
  • METHODS: Review of the literature for articles describing studies of HBV genotype/subgenotypes and development of HCC, cirrhosis, and liver-related death.

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  • (PMID = 19669359.001).
  • [ISSN] 1936-0533
  • [Journal-full-title] Hepatology international
  • [ISO-abbreviation] Hepatol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2716762
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30. Hoffmann C: [Non-AIDS-defining malignancies]. MMW Fortschr Med; 2008 Apr 28;150 Spec No 1:26-8
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  • [Title] [Non-AIDS-defining malignancies].
  • [Transliterated title] Nicht-AIDS-definierende Tumoren. Immer mehr HIV-Patienten sterben an Krebs.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / mortality. Anus Neoplasms / diagnosis. Anus Neoplasms / mortality. Carcinoma, Bronchogenic / diagnosis. Carcinoma, Bronchogenic / mortality. Cause of Death. Cross-Sectional Studies. Germany. Humans. Lung Neoplasms / diagnosis. Lung Neoplasms / mortality. Papillomavirus Infections / diagnosis. Papillomavirus Infections / mortality. Survival Rate


31. Ramdial PK, Sing Y, Chotey NA, Bagratee JS: Concomitant malacoplakia and granuloma inguinale of the cervix in acquired immune deficiency syndrome. Int J Gynecol Pathol; 2008 Apr;27(2):282-7
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  • We describe concomitant granuloma inguinale (GI) and malacoplakia of the cervix in 2 acquired immune deficiency syndrome (AIDS) patients aged 27 and 36 years.
  • Speculum examination confirmed cervical ulceration, prompting the diagnosis of cervical carcinoma in both patients.
  • Malacoplakia of the female genital tract is documented rarely and remains unreported, to date, in AIDS patients.
  • Similar to the pathogenetic mechanisms described for AIDS-associated malacoplakia in extragenital sites, it is hypothesized that, in addition to abnormal macrophage functioning and an inability to degrade bacteria, special constituents of K. granulomatis are undigestable by lysosomal enzymes in human immunodeficiency virus-infected patients.
  • [MeSH-major] AIDS-Related Opportunistic Infections / virology. Acquired Immunodeficiency Syndrome / complications. Granuloma Inguinale / virology. Klebsiella Infections / virology. Malacoplakia / virology. Uterine Cervical Diseases / virology


32. Potthoff A, Brockmeyer NH: [HIV-associated tumors]. Hautarzt; 2006 Nov;57(11):988, 990-3
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  • In the beginning of the HIV epidemic, Kaposi sarcoma was a common stigma in AIDS patients and one of the leading causes of death.
  • The incidence of HPV-related anal carcinoma and its precursor lesions is rising so dramatically that screening programs as they are already established for cervical carcinoma should be implemented.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. Adult. Antiretroviral Therapy, Highly Active. Anus Neoplasms / etiology. Carcinoma, Hepatocellular / etiology. Female. HIV Seropositivity / complications. Humans. Liver Neoplasms / etiology. Lung Neoplasms / drug therapy. Lung Neoplasms / etiology. Lymphoma, AIDS-Related / diagnosis. Lymphoma, AIDS-Related / drug therapy. Lymphoma, AIDS-Related / etiology. Male. Middle Aged. Papillomavirus Infections / complications. Risk Factors. Skin Neoplasms / etiology. Smoking / adverse effects. Uterine Cervical Neoplasms / etiology


33. Apostolova N, Gomez-Sucerquia LJ, Moran A, Alvarez A, Blas-Garcia A, Esplugues JV: Enhanced oxidative stress and increased mitochondrial mass during efavirenz-induced apoptosis in human hepatic cells. Br J Pharmacol; 2010 Aug;160(8):2069-84
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  • Though highly efficient, there is growing concern about EFV-related side effects, the molecular basis of which remains elusive.
  • [MeSH-minor] Antioxidants / pharmacology. Apoptosis Regulatory Proteins / metabolism. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cell Cycle / drug effects. Cell Proliferation / drug effects. Cell Survival / drug effects. Chromans / pharmacology. Chromatin Assembly and Disassembly / drug effects. Dose-Response Relationship, Drug. Female. Glutathione / metabolism. HeLa Cells. Humans. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Male. Phosphatidylserines / metabolism. Superoxides / metabolism. Time Factors

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  • (PMID = 20649602.001).
  • [ISSN] 1476-5381
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Antioxidants; 0 / Apoptosis Regulatory Proteins; 0 / Benzoxazines; 0 / Chromans; 0 / Phosphatidylserines; 11062-77-4 / Superoxides; GAN16C9B8O / Glutathione; JE6H2O27P8 / efavirenz; S18UL9710X / 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
  • [Other-IDs] NLM/ PMC2958650
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34. Vogel M, Boesecke C, Wasmuth JC, Rockstroh JK: [HIV and hepatitis C co-infection]. Dtsch Med Wochenschr; 2010 Jun;135(23):1186-91
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  • The progression of chronic HCV infection to liver cirrhosis with subsequent risk for liver decompensation and hepatocellular carcinoma is substantially accelerated in HIV/HCV co-infected compared to HCV mono-infected individuals, particularly with advanced levels of immunodeficiency.
  • [MeSH-major] AIDS-Related Opportunistic Infections / drug therapy. Antiretroviral Therapy, Highly Active. Antiviral Agents / therapeutic use. Hepatitis C, Chronic / drug therapy


35. Lanoy E, Dores GM, Madeleine MM, Toro JR, Fraumeni JF Jr, Engels EA: Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS; 2009 Jan 28;23(3):385-93
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  • [Title] Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States.
  • We evaluated skin cancer epidemiology among persons with AIDS.
  • DESIGN: We linked data from population-based US AIDS and cancer registries to evaluate risk of nonkeratinocytic skin cancers (melanoma, Merkel cell carcinoma, and appendageal carcinomas, including sebaceous carcinoma) in 497 142 persons with AIDS.
  • RESULTS: From 60 months before to 60 months after AIDS onset, persons with AIDS had elevated risks of melanoma (SIR = 1.3, 95% confidence interval 1.1-1.4, n = 292 cases) and, more strongly, of Merkel cell carcinoma (SIR = 11, 95% confidence interval 6.3-17, n = 17) and sebaceous carcinoma (SIR = 8.1, 95% confidence interval 3.2-17, n = 7).
  • Risk for appendageal carcinomas increased with progressive time relative to AIDS onset (P trend = 0.03).
  • Melanoma risk was unrelated to CD4 cell count at AIDS onset (P = 0.32).
  • CONCLUSION: Among persons with AIDS, there is a modest excess risk of melanoma, which is not strongly related to immunosuppression and may relate to ultraviolet radiation exposure.
  • In contrast, the greatly increased risks for Merkel cell and sebaceous carcinoma suggest an etiologic role for immunosuppression.
  • [MeSH-minor] Adenocarcinoma, Sebaceous / epidemiology. Adenocarcinoma, Sebaceous / immunology. Adenocarcinoma, Sebaceous / virology. Adolescent. Adult. CD4 Lymphocyte Count. Carcinoma, Merkel Cell / epidemiology. Carcinoma, Merkel Cell / immunology. Carcinoma, Merkel Cell / virology. Child. Child, Preschool. Epidemiologic Methods. Female. Humans. Immunocompromised Host. Infant. Infant, Newborn. Male. Melanoma / epidemiology. Melanoma / immunology. Melanoma / virology. Middle Aged. United States / epidemiology. Young Adult

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  • (PMID = 19114864.001).
  • [ISSN] 1473-5571
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010150-08
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS89955; NLM/ PMC2728602
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36. Gohy L, Gorska I, Rouleau D, Ghattas G, Pokomandy Ad, Vézina S, Coté P, Macleod J, Allaire G, Hadjeres R, Kornegay JR, Franco E, HIPVIRG Study Group, Coutlée F: Genotyping of human papillomavirus DNA in anal biopsies and anal swabs collected from HIV-seropositive men with anal dysplasia. J Acquir Immune Defic Syndr; 2008 Sep 1;49(1):32-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Diseases / virology. Carcinoma in Situ / complications. Carcinoma in Situ / virology. DNA, Viral. HIV Seropositivity / virology
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. AIDS-Related Opportunistic Infections / virology. Adolescent. Adult. Aged. Biopsy. Genotype. Humans. Male. Middle Aged. Papillomavirus Infections / complications. Papillomavirus Infections / virology. Polymerase Chain Reaction

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  • (PMID = 18667921.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Investigator] OAllaire G; Baril JG; Boissonnault M; Charest L; Charron MA; Cote S; Cote P; Coutlee F; de Pokomandy A; Dion H; Dufresne S; Falutz J; Fortin C; Franco E; Ghattas G; Gilmore N; Gorska I; Hadjeres R; Junod P; Klein M; Lalonde R; Laplante F; Leblanc R; Legault D; Lessard B; Longpre D; Mcleod J; Maziade JP; Murphy D; Nguyen VK; O'Brien R; Phaneuf D; Rouleau D; Routy JP; Szabo J; Tessier D; Thomas R; Toma E; Tremblay C; Trepanier JM; Trottier B; Tsoukas C; Turner H; Vezina S
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37. Koljonen V, Kukko H, Pukkala E, Sankila R, Böhling T, Tukiainen E, Sihto H, Joensuu H: Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma. Br J Cancer; 2009 Oct 20;101(8):1444-7
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  • [Title] Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma.
  • BACKGROUND: Immunosuppression and Merkel-cell polyomavirus (MCPyV) infection may have a role in the pathogenesis of Merkel-cell carcinoma (MCC), a rare neuroendocrine carcinoma of the skin.
  • Immunosuppression related with CLL and viral infection might explain the association between CLL and MCC.
  • [MeSH-major] Carcinoma, Merkel Cell / etiology. Leukemia, Lymphocytic, Chronic, B-Cell / complications. Merkel Cells / virology. Polyomavirus / isolation & purification

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  • (PMID = 19755994.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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  • [Other-IDs] NLM/ PMC2768432
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38. Cresti S, Ouaïssi M, Sielezneff I, Chaix JB, Pirro N, Berthet B, Consentino B, Sastre B: Advantage of vacuum assisted closure on healing of wound associated with omentoplasty after abdominoperineal excision: a case report. World J Surg Oncol; 2008;6:136
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  • BACKGROUND: Primary closure of the perineum with drainage after abdominoperineal excision of the rectum for carcinoma, is widely accepted.
  • Those complications are frequently related to the patients' clinical antecedent (i.e radiotherapy, diabetes, smoking).
  • CASE PRESENTATION: In the present report, vacuum assisted drainage was used after abdominoperineal excision for carcinoma in the very first step due to intraoperative gross septic contamination during tumor resection.
  • The second case: A 51-year-old man, with AIDS.

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  • (PMID = 19102785.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2621222
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39. Molton IR, Siegel SD, Penedo FJ, Dahn JR, Kinsinger D, Traeger LN, Carver CS, Shen BJ, Kumar M, Schneiderman N, Antoni MH: Promoting recovery of sexual functioning after radical prostatectomy with group-based stress management: the role of interpersonal sensitivity. J Psychosom Res; 2008 May;64(5):527-36
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  • OBJECTIVE: Treatment for localized prostate carcinoma (PCa) is frequently associated with decrements in sexual functioning and satisfaction.
  • RESULTS: At baseline, interpersonal sensitivity was related to a belief linking sexual dysfunction to core male identity (r=.29, P<.05).

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  • (PMID = 18440406.001).
  • [ISSN] 0022-3999
  • [Journal-full-title] Journal of psychosomatic research
  • [ISO-abbreviation] J Psychosom Res
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR016587; United States / NCRR NIH HHS / RR / M01 RR016587-030002; United States / NCRR NIH HHS / RR / RR016587-040002; United States / NCI NIH HHS / CA / P50 CA084944; United States / NCRR NIH HHS / RR / RR016587-030002; United States / NCI NIH HHS / CA / 1P50CA84944; United States / NCRR NIH HHS / RR / M01 RR016587-040002
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS49867; NLM/ PMC2429960
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40. Strickler HD, Burk RD, Fazzari M, Anastos K, Minkoff H, Massad LS, Hall C, Bacon M, Levine AM, Watts DH, Silverberg MJ, Xue X, Schlecht NF, Melnick S, Palefsky JM: Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women. J Natl Cancer Inst; 2005 Apr 20;97(8):577-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] AIDS-Related Opportunistic Infections / virology. Carcinoma, Squamous Cell / virology. HIV. HIV Seropositivity / complications. Papillomaviridae. Papillomavirus Infections / complications. Uterine Cervical Neoplasms / virology

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  • (PMID = 15840880.001).
  • [ISSN] 1460-2105
  • [Journal-full-title] Journal of the National Cancer Institute
  • [ISO-abbreviation] J. Natl. Cancer Inst.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / CA85178-01; United States / NCRR NIH HHS / RR / M01-RR-00079; United States / NCRR NIH HHS / RR / M01-RR-00083; United States / NIAID NIH HHS / AI / U01 AI-35004; United States / NIAID NIH HHS / AI / U01-AI-31834; United States / NIAID NIH HHS / AI / U01-AI-34994; United States / NICHD NIH HHS / HD / U01-HD-32632
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / RNA, Viral
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41. Saif MW, Kaley K, Lamb L, Pecerillo J, Hotchkiss S, Steven L, Brennan M, Penney R, Gillespie C, Shaib W: Management of skin toxicities of anti-EGFR agents in patients with pancreatic cancer and other GI tumors by using electronic communication: effective and convenient. JOP; 2010;11(2):176-82
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  • We suggest that electronic communication is of crucial importance to detect early, diagnose and treat anti-EGFR related skin rash in order to continue the benefit of anti-EGFR.
  • [MeSH-major] Carcinoma / drug therapy. Electronic Mail. Gastrointestinal Neoplasms / drug therapy. Pancreatic Neoplasms / drug therapy. Protein Kinase Inhibitors / adverse effects. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Skin Diseases / chemically induced. Skin Diseases / therapy. Telecommunications
  • [MeSH-minor] Adverse Drug Reaction Reporting Systems. Algorithms. Audiovisual Aids. Communication. Continuity of Patient Care. Drug-Related Side Effects and Adverse Reactions / therapy. Efficiency. Health Services Accessibility. Humans. Patient Compliance. Physician-Patient Relations


42. Aiello-Laws L, Rutledge DN: Management of adult patients receiving intraventricular chemotherapy for the treatment of leptomeningeal metastasis. Clin J Oncol Nurs; 2008 Jun;12(3):429-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Acquired Immunodeficiency Syndrome / complications. Adult. Blepharoptosis / etiology. Brain Neoplasms / pathology. Carcinoma / drug therapy. Carcinoma / nursing. Carcinoma / secondary. Drug Compounding. Drug Monitoring / nursing. Evidence-Based Medicine. Fatal Outcome. Humans. Low Back Pain / etiology. Lymphoma, AIDS-Related / complications. Male. Muscle Weakness / etiology. Nurse's Role. Nursing Assessment. Practice Guidelines as Topic

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  • (PMID = 18515241.001).
  • [ISSN] 1092-1095
  • [Journal-full-title] Clinical journal of oncology nursing
  • [ISO-abbreviation] Clin J Oncol Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 04079A1RDZ / Cytarabine
  • [Number-of-references] 30
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43. Loya AC, Prayaga AK, Sundaram C, Shantharam V, Kumar A: Cytologic diagnosis of pancreatic tuberculosis in immunocompetent and immunocompromised patients: a report of 2 cases. Acta Cytol; 2005 Jan-Feb;49(1):97-100
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  • Pancreatic involvement by tuberculosis in immunocompromised states, such as AIDS, and isolated involvement in immunocompetent patients require a high index of suspicion.
  • CASES: A patient presented with diabetes mellitus and a pancreatic mass clinically diagnosed as pancreatic carcinoma.
  • [MeSH-minor] AIDS-Related Opportunistic Infections. Adult. Biopsy, Fine-Needle. Carcinoma / diagnosis. Diabetes Mellitus / physiopathology. Diagnosis, Differential. Fatal Outcome. HIV Seropositivity. Humans. Immunocompromised Host. Lymphatic Diseases / pathology. Lymphoma, Non-Hodgkin / diagnosis. Male. Middle Aged. Pancreas / pathology. Pancreas / radiography. Pancreatic Neoplasms / diagnosis. Tomography, X-Ray Computed


44. Chasan R, Reese L, Fishbein D: HIV and Hepatitis B Virus Coinfection: Approach to Management: Case Study and Commentary. J Clin Outcomes Manag; 2010 Jun 01;17(6):273-286
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  • Once engaged in care, coinfected patients should receive treatment for both HIV and chronic hepatitis B with the goal of a decrease in liver failure, cirrhosis, hepatocellular carcinoma, and chronic hepatitis B-related mortality.

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  • (PMID = 23761953.001).
  • [ISSN] 1079-6533
  • [Journal-full-title] Journal of clinical outcomes management : JCOM
  • [ISO-abbreviation] J Clin Outcomes Manag
  • [Language] eng
  • [Grant] United States / CCR NIH HHS / RC / HHSN261200800001C; United States / NCI NIH HHS / CA / HHSN261200800001E; United States / NIDA NIH HHS / DA / K23 DA018623
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. Sahoo S: HIV- and AIDS-related Ocular Manifestations in Tanzanian Patients. Malays J Med Sci; 2010 Jan;17(1):12-6
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  • [Title] HIV- and AIDS-related Ocular Manifestations in Tanzanian Patients.
  • The objective of this study was to describe the ocular manifestations of HIV and AIDS-related patients who had been admitted to TM Jafferji Hospital, Dar-es-Salaam, Tanzania.
  • The notable ocular manifestations included micro-vasculopathy of the retina in 25%, uveitis in 8%, CMV retinitis in 7%, neuro-ophthalmic manifestation in 6%, Herpes zoster ophthalmicus in 5%, Kaposi's sarcoma in 3% and conjunctival carcinoma in 2% of cases.

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  • (PMID = 22135520.001).
  • [ISSN] 2180-4303
  • [Journal-full-title] The Malaysian journal of medical sciences : MJMS
  • [ISO-abbreviation] Malays J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
  • [Other-IDs] NLM/ PMC3216149
  • [Keywords] NOTNLM ; AIDS / CMV retinitis / HIV / medical sciences / micro-vasculopathy
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46. Seoane Lestón J, Diz Dios P: Diagnostic clinical aids in oral cancer. Oral Oncol; 2010 Jun;46(6):418-22
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  • [Title] Diagnostic clinical aids in oral cancer.
  • In the near future, immunological and biochemical alterations in the serum (e.g., circulating immune complexes, carcinoembryonic antigen, squamous cell carcinoma associated antigen, inhibitor of apoptosis, cytokeratin fragments, and annexin A1) as well as specific saliva analysis (e.g., cancer related cytokines, metalloproteinases, epithelial tumour markers, DNA promoter hypermethylation, and saliva micro-RNA) may become important tools for the detection of oral cancer.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Coloring Agents. Luminescence. Mouth Neoplasms / diagnosis. Precancerous Conditions / diagnosis. Tolonium Chloride

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20371204.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Coloring Agents; 15XUH0X66N / Tolonium Chloride
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47. Micco L, Fiorino S, Loggi E, Lorenzini S, Vitale G, Cursaro C, Riili A, Bernardi M, Andreone P: Polymorphism rtQ215H in primary resistance to adefovir dipivoxil in hepatitis B virus infection: a case report. BMJ Case Rep; 2009;2009
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  • Here we report a case of a patient with HBV infection and hepatocellular carcinoma who started LAM therapy and subsequently developed virological breakthrough.
  • Virological evaluations showed two well-known LAM-related mutations (rtL180M and rtM204I) in addition to reverse-transcriptase rtQ215H.

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  • [ISSN] 1757-790X
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48. Sulkowski MS: Hepatitis C virus infection in HIV-infected patients. Curr Infect Dis Rep; 2007 Oct;3(5):469-76
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  • Since its discovery in 1989, HCV has been recognized as a major cause of chronic hepatitis and hepatic fibrosis that progresses in some patients to cirrhosis and hepatocellular carcinoma.
  • In addition, HIV co-infection is associated with higher HCV RNA viral load and a more rapid progression of HCV-related liver disease, leading to an increased risk of cirrhosis.
  • Strategies to prevent primary HCV infection and to modify the progression of HCV-related liver disease are urgently needed among HIV/HCV co-infected individuals.

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  • (PMID = 24395487.001).
  • [ISSN] 1523-3847
  • [Journal-full-title] Current infectious disease reports
  • [ISO-abbreviation] Curr Infect Dis Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Rosenthal E, Pialoux G, Bernard N, Pradier C, Rey D, Bentata M, Michelet C, Pol S, Perronne C, Cacoub P, GERMIVIC Joint Study Group: Liver-related mortality in human-immunodeficiency-virus-infected patients between 1995 and 2003 in the French GERMIVIC Joint Study Group Network (MORTAVIC 2003 Study). J Viral Hepat; 2007 Mar;14(3):183-8
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  • [Title] Liver-related mortality in human-immunodeficiency-virus-infected patients between 1995 and 2003 in the French GERMIVIC Joint Study Group Network (MORTAVIC 2003 Study).
  • Among 215 deaths observed during 2003, 101 (46.9%) were related to AIDS, 27 (12.6%) to ESLD and 87 (40.5%) to other causes.
  • Mortality because of ESLD represented 23.7% of non-AIDS-related deaths.
  • The prevalence of hepatocellular carcinoma as a cause of death remained high in 2003 but stable when compared with 2001 (25%vs 14.8%).
  • [MeSH-minor] Adult. Aged. Carcinoma, Hepatocellular / mortality. Female. France. Hepatitis C, Chronic / mortality. Humans. Liver Diseases, Alcoholic / mortality. Liver Neoplasms / mortality. Male. Middle Aged

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  • (PMID = 17305884.001).
  • [ISSN] 1352-0504
  • [Journal-full-title] Journal of viral hepatitis
  • [ISO-abbreviation] J. Viral Hepat.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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50. Panther LA, Schlecht HP, Dezube BJ: Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients. AIDS Read; 2005 Feb;15(2):79-82, 85-6, 88, 91
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  • [Title] Spectrum of human papillomavirus-related dysplasia and carcinoma of the anus in HIV-infected patients.
  • The incidence of human papillomavirus (HPV)-related anal squamous cell carcinoma is increasing.
  • It is likely that long-standing HIV-related immunosuppression plays a significant role in the pathogenesis of anal carcinoma; however, a direct HIV-HPV interaction has also been implicated.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. HIV Infections / epidemiology. Papillomaviridae / isolation & purification. Papillomavirus Infections / epidemiology. Precancerous Conditions / pathology


51. Lim ST, Levine AM: Non-AIDS-defining cancers and HIV infection. Curr HIV/AIDS Rep; 2005 Aug;2(3):146-53
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  • [Title] Non-AIDS-defining cancers and HIV infection.
  • With fewer patients now succumbing to infectious complications of AIDS, other HIV-related morbidities, such as malignancies, have become increasingly important.
  • Apart from Kaposi's sarcoma, non-Hodgkin's lymphoma, and cervical cancer, which are considered as AIDS-defining, several additional cancers, referred to as non-AIDS-defining cancers, are also statistically increased in HIV-infected persons.
  • These include Hodgkin's disease, anal carcinoma, lung cancer, nonmelanomatous skin cancer, and testicular germ cell tumors, among others.
  • Although immunosuppression is consistently associated with an increased risk of AIDS-related malignancies, the role of immunosuppression in the pathogenesis of non-AIDS- defining cancers is controversial.

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  • (PMID = 16091262.001).
  • [ISSN] 1548-3568
  • [Journal-full-title] Current HIV/AIDS reports
  • [ISO-abbreviation] Curr HIV/AIDS Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 64
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52. Yu J, Solano FX Jr, Seethala RR: Bilateral cytomegalovirus (CMV) oophoritis mimicking widely metastatic carcinoma: a case report and review of the literature. Diagn Pathol; 2007;2:50
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  • [Title] Bilateral cytomegalovirus (CMV) oophoritis mimicking widely metastatic carcinoma: a case report and review of the literature.
  • While age related vasculopathy was thought to be the prevailing mechanism for CMV oophoritis, the observation of an inflammation mediated microthrombosis in our case provides a plausible age independent mechanism suggesting that both restrictive and obstructive vascular changes can be involved in the pathogenesis of CMV oophoritis.

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  • (PMID = 18096056.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2245911
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53. Ramírez-Olivencia G, Valencia-Ortega ME, Martin-Carbonero L, Moreno-Celda V, González-Lahoz J: [Malignancies in HIV infected patients: study of 139 cases]. Med Clin (Barc); 2009 Nov 21;133(19):729-35
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  • Information was collected on age, sex, risk factors for HIV, HBV/HCV coinfection, malignancies, diagnosis of AIDS, viral load and CD4 cell counts at diagnosis, antiretroviral therapy and mortality.
  • RESULTS: Types of malignancy were Kaposi's Sarcoma (n=43, 30.9%); non-Hodgkin lymphoma (n=42, 30.2%); gynecologic malignancy (n=16, 11.5%); Hodgkin's disease (n=15, 10.8%); hepatocellular carcinoma (n=7, 5%) and others (n=16, 11.5%).
  • CONCLUSIONS: Increased survival of HIV-infected patients receiving HAART makes it possible the development of secondary tumors and AIDS- unrelated malignancies, sometimes related to another virus.

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  • (PMID = 19880148.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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54. Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, Su D, Sano M, Lytwyn A, Chapman W, Mahony J: Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology. Cancer Epidemiol Biomarkers Prev; 2009 Jul;18(7):1986-92
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  • In the multivariable logistic regression model, HPV genotypes 16 [odds ratio, 2.58; 95% confidence interval (95% CI), 1.31-5.08; P = 0.006] and 31 (odds ratio, 4.74; 95% CI, 2.00-11.22; P = 0.0004), baseline CD4 count < 400 cells/mm(3) (odds ratio, 2.96; 95% CI, 1.46-5.99; P = 0.0025), and Acquired Immunodeficiency Syndrome (AIDS)-defining illness (odds ratio, 2.42; 95% CI, 1.22-4.82; P = 0.01) were associated with high-grade histology after adjusting for age.
  • [MeSH-major] Alphapapillomavirus / genetics. Anus Neoplasms / epidemiology. Carcinoma in Situ / epidemiology. Genes, p16. HIV Seropositivity / virology. Oncogene Proteins, Viral / genetics. Repressor Proteins / genetics
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. AIDS-Related Opportunistic Infections / virology. DNA, Viral / analysis. Genotype. Homosexuality, Male. Humans. Male. Papillomavirus Infections / complications. Papillomavirus Infections / epidemiology. Papillomavirus Infections / pathology. Papillomavirus Infections / virology. Risk Factors. Viral Load

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  • (PMID = 19567510.001).
  • [ISSN] 1538-7755
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / E6 protein, Human papillomavirus type 16; 0 / Oncogene Proteins, Viral; 0 / Repressor Proteins
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55. National Toxicology Program: Toxicology and carcinogenesis studies of transplacental AZT (Cas No. 30516-87-1) in Swiss (CD-1®) mice (in utero studies). Natl Toxicol Program Tech Rep Ser; 2006 Jun;(522):1-184
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  • 3'-Azido-3'-deoxythymidine (AZT) is the most widely used and evaluated chemotherapeutic agent for the treatment of persons with acquired immune deficiency syndrome (AIDS) and persons seropositive for human immunodeficiency virus (HIV).
  • The incidences of alveolar/bronchiolar carcinoma and of adenoma or carcinoma (combined) in 200 and 300 mg/kg males were significantly greater than those in the vehicle controls.
  • The percentage of PCEs was decreased in all pups exposed to AZT, consistent with treatment-related bone marrow toxicity.

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  • (PMID = 17160102.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens; 4B9XT59T7S / Zidovudine
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56. Kreuter A, Wieland U, Gambichler T, Altmeyer P, Pfister H, Tenner-Racz K, Racz P, Potthoff A, Brockmeyer NH, German Network of Competence HIV/AIDS: p16ink4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus-infected men and correlates with the decline of lesional high-risk human papillomavirus DNA load. Br J Dermatol; 2007 Sep;157(3):523-30
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  • [MeSH-major] Aminoquinolines / therapeutic use. Antineoplastic Agents / therapeutic use. Anus Neoplasms / drug therapy. Carcinoma in Situ / drug therapy. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Precancerous Conditions / drug therapy
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. Administration, Cutaneous. Adult. Biomarkers, Tumor / metabolism. DNA, Viral / analysis. Homosexuality, Male. Humans. Ki-67 Antigen / metabolism. Male. Papillomaviridae / genetics. Papillomavirus Infections / complications. Papillomavirus Infections / metabolism. Pilot Projects. Viral Load

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  • (PMID = 17573882.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00365729
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / Ki-67 Antigen; 99011-02-6 / imiquimod
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57. Takacs M, Segesdi J, Banati F, Koroknai A, Wolf H, Niller HH, Minarovits J: The importance of epigenetic alterations in the development of epstein-barr virus-related lymphomas. Mediterr J Hematol Infect Dis; 2009;1(2):e2009012
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  • [Title] The importance of epigenetic alterations in the development of epstein-barr virus-related lymphomas.
  • These include lymphomas (Burkitt's lymphoma, Hodgkin's disease, T/NK-cell lymphoma, post-transplant lymphoproliferative disease, AIDS-associated lymphoma, X-linked lymphoproliferative syndrome), carcinomas (nasopharyngeal carcinoma, gastric carcinoma, carcinomas of major salivary glands, thymic carcinoma, mammary carcinoma) and a sarcoma (leiomyosarcoma).

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  • (PMID = 21416002.001).
  • [ISSN] 2035-3006
  • [Journal-full-title] Mediterranean journal of hematology and infectious diseases
  • [ISO-abbreviation] Mediterr J Hematol Infect Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3033174
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58. Aulmann S, Schleibaum J, Penzel R, Schirmacher P, Gebauer G, Sinn HP: Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status. J Clin Pathol; 2008 Sep;61(9):1034-7
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  • [Title] Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status.
  • (1) usual-type (bowenoid) VIN, which is related to high-risk papillomavirus infection, and (2) differentiated (simplex) VIN, which is associated with chronic inflammation.
  • CONCLUSIONS: Immunohistochemical evaluation of p16 and p53 expression aids in the differential diagnosis of squamous cell alterations of the vulva.
  • [MeSH-major] Carcinoma in Situ / genetics. Carcinoma, Squamous Cell / genetics. Chromosome Aberrations. Chromosomes, Human, Pair 3 / genetics. Vulvar Neoplasms / genetics

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  • (PMID = 18559375.001).
  • [ISSN] 1472-4146
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p53
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59. Gupta S, Altice FL: Hepatitis B virus infection in US correctional facilities: a review of diagnosis, management, and public health implications. J Urban Health; 2009 Mar;86(2):263-79
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  • Despite the availability of HBV vaccine for the last 15 years, more than 1.25 million individuals in the USA have chronic HBV infection, and about 5,000 die each year from HBV-related complications.
  • The economic and public health burden of chronic hepatitis B and its sequelae, including cirrhosis and hepatocellular carcinoma, is felt most prominently in managed care settings with limited budgets, like correctional facilities.

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  • (PMID = 19184447.001).
  • [ISSN] 1468-2869
  • [Journal-full-title] Journal of urban health : bulletin of the New York Academy of Medicine
  • [ISO-abbreviation] J Urban Health
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / K24 DA017072; United States / NIDA NIH HHS / DA / K24-DA017072
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 81
  • [Other-IDs] NLM/ PMC2648882
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60. Neuman MG, Monteiro M, Rehm J: Drug interactions between psychoactive substances and antiretroviral therapy in individuals infected with human immunodeficiency and hepatitis viruses. Subst Use Misuse; 2006;41(10-12):1395-463
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  • The liver disease characteristic of alcohol dependence encompasses three main related entities: steatosis, alcoholic hepatitis, and cirrhosis.
  • HIV and HCV coinfected patients develop liver diseases earlier and more severely than the monoinfected individuals, including hepatocellular carcinoma.
  • With the evolution of effective antiretroviral therapy, survival of persons with HIV, and the syndrome it causes, acquired immunodeficiency syndrome (AIDS) has increased dramatically.
  • Several other medical-, social-, and drug-related factors of this population have to be considered when providing HAART.


61. Bräu N: Treatment of chronic hepatitis C in human immunodeficiency virus/hepatitis C virus-coinfected patients in the era of pegylated interferon and ribavirin. Semin Liver Dis; 2005 Feb;25(1):33-51
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  • HIV/HCV-coinfected patients with ongoing HIV viremia have a faster rate of HCV-related liver fibrosis progression and a more rapid progression to liver failure or hepatocellular carcinoma than HCV-monoinfected persons.
  • In contrast to the deleterious effect of HIV on HCV-related liver disease, most studies have shown that HCV does not influence progression of HIV infection to AIDS or death.


62. Leone N, Rizzetto M: Natural history of hepatitis C virus infection: from chronic hepatitis to cirrhosis, to hepatocellular carcinoma. Minerva Gastroenterol Dietol; 2005 Mar;51(1):31-46
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  • [Title] Natural history of hepatitis C virus infection: from chronic hepatitis to cirrhosis, to hepatocellular carcinoma.
  • In patients with cirrhosis, the incidence of hepatocellular carcinoma is 2-5% per year.
  • At present, HCV-related end-stage cirrhosis is the first cause of liver transplantation.
  • [MeSH-major] Carcinoma, Hepatocellular / etiology. Hepatitis C / complications. Hepatitis C, Chronic / complications. Liver Cirrhosis / etiology. Liver Neoplasms / etiology
  • [MeSH-minor] AIDS-Related Opportunistic Infections. Adult. Clinical Enzyme Tests. Disease Progression. Female. Follow-Up Studies. Genotype. Hepacivirus / genetics. Humans. Immunocompromised Host. Liver Transplantation. Male. RNA, Viral / analysis. Time Factors. Viral Load

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  • (PMID = 15756144.001).
  • [ISSN] 1121-421X
  • [Journal-full-title] Minerva gastroenterologica e dietologica
  • [ISO-abbreviation] Minerva Gastroenterol Dietol
  • [Language] eng; ita
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / RNA, Viral
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63. Akanmu AS: AIDS-associated malignancies. Afr J Med Med Sci; 2006 Dec;35 Suppl:57-70
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  • [Title] AIDS-associated malignancies.
  • Three neoplastic diseases are associated so commonly with HIV infection that each of them has become recognized as an AIDS defining illness.
  • These are Kaposi's Sarcoma (KS), Non-Hodgkin's Lymphoma (NHL) and Cervical Carcinoma.
  • Both KS and NHL were recognized as AIDS associated cancers from the onset of the epidemic in 1981 but carcinoma of the cervix became AIDS defining in 1993.
  • [MeSH-major] HIV. Lymphoma, AIDS-Related / epidemiology. Lymphoma, Non-Hodgkin / epidemiology. Sarcoma, Kaposi / epidemiology

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  • (PMID = 18050776.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Nigeria
  • [Number-of-references] 114
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64. Gaughan EM, Dezube BJ, Aboulafia D, Bower M, Stebbing J, Powles T, Pantanowitz L: Human immunodeficiency virus--associated renal cell carcinoma: a transatlantic case series. Clin Genitourin Cancer; 2008 Sep;6(2):86-90
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  • [Title] Human immunodeficiency virus--associated renal cell carcinoma: a transatlantic case series.
  • Non-AIDS-defining cancers, including renal cell carcinoma (RCC), are being recognized increasingly in this population.
  • RESULTS: Renal cell carcinoma was diagnosed in patients with a median age of 48 years, and most had a history of tobacco use.
  • No association between HIV-related immunosuppression (mean CD4 count, 301 cells/mm3) and the development, clinical presentation, pathology, or behavior of RCC was identified.
  • CONCLUSION: Renal cell carcinoma should be included in the expanding array of non-AIDS-defining malignancies that develop during the course of HIV infection.
  • [MeSH-major] Carcinoma, Renal Cell / complications. HIV Infections / complications. Kidney Neoplasms / complications


65. Roma AA, Goldblum JR, Fazio V, Yang B: Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma. Int J Clin Exp Pathol; 2008;1(5):419-25
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  • [Title] Expression of 14-3-3sigma, p16 and p53 proteins in anal squamous intraepithelial neoplasm and squamous cell carcinoma.
  • 14-3-3sigma is a p53-regulated G2/M inhibitor involved in numerous cellular signaling pathways related to cell cycle, DNA repair and apoptosis.
  • Recent studies have showed that 14-3-3sigma was silenced transcriptionally through promoter hypermethylation mainly in HPV-negative vulvar squamous cell carcinoma (SCC).

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  • (PMID = 18787619.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2480570
  • [Keywords] NOTNLM ; 14-3-3σ / AIN / Anal intraepithelial neoplasm / Bowenoid / differentiated / p16 / p53 / simplex
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66. Zeuzem S: [Treatment of hepatitis C virus infection]. Praxis (Bern 1994); 2005 May 4;94(18):721-6
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  • Possibly, interferon-alpha also reduces the risk for patients with chronic hepatitis C to develop hepatocellular carcinoma.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / drug therapy. Acute Disease. Clinical Trials as Topic. Drug Therapy, Combination. Genotype. Hepacivirus / genetics. Humans. Longitudinal Studies. Meta-Analysis as Topic. RNA, Viral / analysis. Recombinant Proteins. Recurrence. Risk Factors. Time Factors. Viral Load

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  • (PMID = 15938383.001).
  • [ISSN] 1661-8157
  • [Journal-full-title] Praxis
  • [ISO-abbreviation] Praxis (Bern 1994)
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Interferon-alpha; 0 / RNA, Viral; 0 / Recombinant Proteins; 0 / peginterferon alfa-2a; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 49717AWG6K / Ribavirin; 76543-88-9 / interferon alfa-2a; 99210-65-8 / interferon alfa-2b
  • [Number-of-references] 33
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67. Frezzini C, Leao JC, Porter S: Current trends of HIV disease of the mouth. J Oral Pathol Med; 2005 Oct;34(9):513-31
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  • There is now considerable understanding of the molecular epidemiology, transmission and therapy of the common opportunistic oral infections of HIV disease, and as a consequence of improved anti-HIV strategies, the frequency and severity of oral disease associated with HIV infection have reduced considerably, although HAART may predispose to human papilloma virus infection of the mouth and potentially increase the risk of later oral squamous cell carcinoma.
  • [MeSH-major] AIDS-Related Opportunistic Infections / etiology. HIV Infections / complications. Mouth Diseases / etiology

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  • (PMID = 16138890.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 261
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68. Buonaguro L, Petrizzo A, Tornesello M, Napolitano M, Martorelli D, Castello G, Beneduce G, De Renzo A, Perrella O, Romagnoli L, Sousa V, De Re V, Dolcetti R, Buonaguro FM: Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders. J Transl Med; 2010;8:18
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  • [Title] Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders.
  • Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may further evolve into an overt B-cell non-Hodgkin's lymphoma (NHL).

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  • (PMID = 20170491.001).
  • [ISSN] 1479-5876
  • [Journal-full-title] Journal of translational medicine
  • [ISO-abbreviation] J Transl Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cytokines; 0 / Immunoglobulin Idiotypes; 0 / Immunoglobulin Variable Region; 0 / Receptors, Antigen, B-Cell; 0 / Viral Vaccines
  • [Other-IDs] NLM/ PMC2839974
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69. Palefsky J: Human papillomavirus-related disease in people with HIV. Curr Opin HIV AIDS; 2009 Jan;4(1):52-6
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  • [Title] Human papillomavirus-related disease in people with HIV.
  • PURPOSE OF REVIEW: The incidence of human papillomavirus (HPV)-related cancers has increased among people with HIV infection compared with the general population.
  • SUMMARY: New data imply that the problem of HPV-related cancers will not decline among HIV-positive men and women in the antiretroviral therapy era, highlighting the need to perform studies to determine if screening and treatment of anal intraepithelial neoplasia will prevent development of anal cancer.

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  • (PMID = 19339939.001).
  • [ISSN] 1746-6318
  • [Journal-full-title] Current opinion in HIV and AIDS
  • [ISO-abbreviation] Curr Opin HIV AIDS
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA054053-08; United States / NCI NIH HHS / CA / R01 CA054053; United States / NCI NIH HHS / CA / R01 CA088739; United States / NCI NIH HHS / CA / R01 CA054053-08; United States / NCI NIH HHS / CA / R01 CA088739-03; United States / NCI NIH HHS / CA / CA088739-03
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents
  • [Number-of-references] 36
  • [Other-IDs] NLM/ NIHMS94538; NLM/ PMC2756707
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70. Fox PA, Tung MY: Human papillomavirus: burden of illness and treatment cost considerations. Am J Clin Dermatol; 2005;6(6):365-81
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  • The duration of treatment is significantly related to the number of warts present, the area covered by the warts, and the length of time the warts have been present.
  • [MeSH-minor] AIDS-Related Opportunistic Infections / complications. AIDS-Related Opportunistic Infections / therapy. Antineoplastic Agents / economics. Antineoplastic Agents / therapeutic use. Carcinoma in Situ / therapy. Carcinoma in Situ / virology. Cryotherapy / economics. Electrosurgery / economics. Female. Humans. Keratolytic Agents / therapeutic use. Laser Therapy / economics. Neoplasms / therapy. Neoplasms / virology. Papillomaviridae. Pregnancy. Pregnancy Complications, Infectious / therapy. Viral Vaccines

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  • (PMID = 16343025.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Keratolytic Agents; 0 / Viral Vaccines
  • [Number-of-references] 136
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71. Santos SA, Kontorinis N, Dieterich DT: Management of chronic hepatitis C virus in patients with HIV. Curr Treat Options Gastroenterol; 2005 Dec;8(6):433-41
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  • HCV leads to a more rapid progression to end-stage liver disease in patients with HIV, and the morbidity and mortality related to HCV in co-infected patients is on the rise.
  • Secondary goals include reduction in hepatic fibrosis progression, development of decompensated cirrhosis, and hepatocellular carcinoma.
  • As a result, we recommend considering all co-infected patients for HCV therapy while watching closely for unique treatment-related toxicities.

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  • (PMID = 16313860.001).
  • [ISSN] 1092-8472
  • [Journal-full-title] Current treatment options in gastroenterology
  • [ISO-abbreviation] Curr Treat Options Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Dahmani O, Target N, Guy J, Belkhelfa S, Jeanvoine FM, Servonnat J, Djellid J: Progressive painless lower limbs weakness in a dialyzed patient: undiagnosed tertiary syphilis: a case report. Cases J; 2010;3:23
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  • CASE PRESENTATION: We describe a rare case of tertiary syphilis in a hemodialyzed diabetic patient whom was career of chronic liver disease due to the evolution of chronic hepatitis B virus infection complicated by a hepatocellular carcinoma.
  • CONCLUSION: This case emphasizes the need for a high index of clinical suspicion for syphilis before the occurrence of symptoms related to its end organ damage dominated by neurosyphilis form.

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  • (PMID = 20180955.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2836290
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73. Tornesello ML, Duraturo ML, Guida V, Losito S, Botti G, Pilotti S, Stefanon B, De Palo G, Buonaguro L, Buonaguro FM: Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma. Cancer Lett; 2008 Sep 28;269(1):159-64
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  • [Title] Analysis of TP53 codon 72 polymorphism in HPV-positive and HPV-negative penile carcinoma.
  • The association of the p53 polymorphism at codon 72 and susceptibility to develop human papillomavirus (HPV)-related cancer has been investigated in several studies with controversial results.
  • In this study, 78 penile squamous cell carcinoma biopsies (n=17 from Uganda, n=61 from Italy) and blood samples from 150 healthy controls (n=57 from Uganda, n=93 from Italy) have been analyzed for the arginine and proline allele distribution.
  • Therefore, no evidence of association between homozygosity for p53 arginine and HPV-related or HPV-unrelated penile squamous cell carcinoma was observed neither among Ugandan nor among Italian populations.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Codon. Genes, p53. Papillomaviridae / isolation & purification. Penile Neoplasms / genetics. Polymorphism, Genetic

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  • (PMID = 18513854.001).
  • [ISSN] 1872-7980
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Codon
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74. Cranston RD, Hart SD, Gornbein JA, Hirschowitz SL, Cortina G, Moe AA: The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. Int J STD AIDS; 2007 Feb;18(2):77-80
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  • [MeSH-major] Anal Canal / pathology. Anus Neoplasms. Carcinoma, Squamous Cell. HIV Infections / complications. Homosexuality, Male
  • [MeSH-minor] AIDS-Related Opportunistic Infections / diagnosis. AIDS-Related Opportunistic Infections / epidemiology. Adult. Aged. Biopsy. Cytological Techniques. Humans. Male. Middle Aged. Predictive Value of Tests. Prevalence

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  • (PMID = 17331275.001).
  • [ISSN] 0956-4624
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Heukamp LC, Fischer HP, Schirmacher P, Chen X, Breuhahn K, Nicolay C, Büttner R, Gütgemann I: Podocalyxin-like protein 1 expression in primary hepatic tumours and tumour-like lesions. Histopathology; 2006 Sep;49(3):242-7
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  • Recently, novel proteins expressed by the neovasculature in hepatocellular carcinoma (HCC) have been identified.
  • The aim of this study was to compare the expression of podocalyxin-like protein 1 (PODXL1), a CD34-related sialomucin, in HCC and benign liver tumours or tumour-like lesions.
  • The presence of CD34+ and PODXL1+ sinusoidal endothelial cells aids in the diagnosis of HCC.

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  • (PMID = 16918970.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD31; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Sialoglycoproteins; 0 / podocalyxin; 0 / von Willebrand Factor
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76. Oliveira-Silva MB, Lages-Silva E, Resende DV, Prata A, Ramirez LE, Frenkel JK: Cystoisospora belli: in vitro multiplication in mammalian cells. Exp Parasitol; 2006 Nov;114(3):189-92
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  • Human ileocecal adenocarcinoma (HCT-8), epithelial carcinoma of lung (A549), Madin-Darby bovine kidney (MDBK), and African green monkey kidney (VERO) were exposed in vitro to C. belli sporozoites, which had been isolated from the feces of HIV-AIDS patients.
  • [MeSH-major] AIDS-Related Opportunistic Infections / parasitology. Coccidiosis / parasitology. Sarcocystidae / growth & development

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  • (PMID = 16674944.001).
  • [ISSN] 0014-4894
  • [Journal-full-title] Experimental parasitology
  • [ISO-abbreviation] Exp. Parasitol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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77. Baillargeon J, Snyder N, Soloway RD, Paar D, Baillargeon G, Spaulding AC, Pollock BH, Arcari CM, Williams BA, Raimer BG: Hepatocellular carcinoma prevalence and mortality in a male state prison population. Public Health Rep; 2009 Jan-Feb;124(1):120-6
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  • [Title] Hepatocellular carcinoma prevalence and mortality in a male state prison population.
  • OBJECTIVES: The incidence of hepatocellular carcinoma (HCC) in the United States has increased dramatically over the last two decades, largely because of an increase in the number of people with advanced hepatitis C virus (HCV) infection. U.S. prisoners are at high risk for HCC, given their elevated rates of HCV infection, comorbid hepatitis B virus (HBV) infection, and alcoholic liver disease.
  • These findings likely reflect the high concentration of HCC-related risk factors, particularly HCV, among prisoners.
  • [MeSH-major] Carcinoma, Hepatocellular / mortality. Liver Neoplasms / mortality. Prisoners

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