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6. Palefsky JM: Anal cancer prevention in HIV-positive men and women. Curr Opin Oncol; 2009 Sep;21(5):433-8
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  • [Title] Anal cancer prevention in HIV-positive men and women.
  • PURPOSE OF REVIEW: The incidence of human papillomavirus-associated anal cancer is unacceptably high among HIV-positive men who have sex with men, and possibly in HIV-positive women.
  • Unlike most other malignancies occurring in the HIV-positive population, anal cancer is potentially preventable, using methods similar to those used to prevent cervical cancer in women.
  • This review discusses the issues around screening to prevent anal cancer.
  • RECENT FINDINGS: Recent studies show that the incidence of anal cancer has increased since the introduction of highly active antiretroviral therapy in this population and now exceeds the highest incidence of cervical cancer among women reported anywhere in the world.
  • SUMMARY: The high incidence of anal cancer among HIV-positive individuals must not be ignored, since it may be preventable.
  • Given the current evidence and analogy with the cervical cancer prevention model, many clinicians believe that identification and treatment of high-grade anal intraepithelial neoplasia to prevent anal cancer are warranted.
  • When the expertise to do so exists, this is a reasonable approach, particularly if coupled with efforts to optimize further screening and treatment approaches, as well as efforts to document the efficacy of high-grade anal intraepithelial neoplasia treatment to reduce the incidence of anal cancer.

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  • (PMID = 19587592.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000079; United States / NCI NIH HHS / CA / CA088739-04S2; United States / NCI NIH HHS / CA / CA054053-10; United States / NCI NIH HHS / CA / R01 CA054053; United States / NCI NIH HHS / CA / U01 CA121947; United States / NCI NIH HHS / CA / R01 CA088739; United States / NCI NIH HHS / CA / R01 CA088739-04S2; United States / NCRR NIH HHS / RR / M01 RR00079; United States / NCI NIH HHS / CA / R01CA 88739; United States / NCI NIH HHS / CA / R01 CA054053-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 17
  • [Other-IDs] NLM/ NIHMS202771; NLM/ PMC3415247
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7. Chandwani S, Wentworth C, Burke TA, Patterson TF: Utilization and dosage pattern of echinocandins for treatment of fungal infections in US hospital practice. Curr Med Res Opin; 2009 Feb;25(2):385-93
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  • Mixed multivariable models were developed to identify factors associated with mean daily dose.
  • Micafungin patients had the highest prevalence of cancer, bone marrow transplant, solid organ transplant, HIV/AIDS, fungal infection, and neutropenia.
  • The first-day dose of echinocandin therapy (vs. subsequent days) was most strongly associated with mean daily dose.

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  • (PMID = 19192983.001).
  • [ISSN] 1473-4877
  • [Journal-full-title] Current medical research and opinion
  • [ISO-abbreviation] Curr Med Res Opin
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antifungal Agents; 0 / Echinocandins
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8. Ginzburg K: Life events and adjustment following myocardial infarction: a longitudinal study. Soc Psychiatry Psychiatr Epidemiol; 2006 Oct;41(10):825-31
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  • RESULTS: Although pre-MI life events were associated with both ASD and PTSD symptom severity, the relation between these events and PTSD was mediated by ASD.
  • DISCUSSION: These findings emphasize the fact that traumatic events do not occur in isolation and that their emotional impact is related to other events that occur both before and after.

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  • [ISSN] 0933-7954
  • [Journal-full-title] Social psychiatry and psychiatric epidemiology
  • [ISO-abbreviation] Soc Psychiatry Psychiatr Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
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9. Mbisa JL, Barr R, Thomas JA, Vandegraaff N, Dorweiler IJ, Svarovskaia ES, Brown WL, Mansky LM, Gorelick RJ, Harris RS, Engelman A, Pathak VK: Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. J Virol; 2007 Jul;81(13):7099-110
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  • However, the decrease in plus-strand DNA transfer did not account for all of the observed decrease in viral DNA synthesis associated with A3G.

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  • (PMID = 17428871.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R29 GM056615; United States / NIAID NIH HHS / AI / R37 AI064046; United States / NIAID NIH HHS / AI / R37 AI039394; United States / NIAID NIH HHS / AI / R01 AI039394; United States / NIGMS NIH HHS / GM / GM56615; United States / Intramural NIH HHS / / ; United States / NIAID NIH HHS / AI / AI064046; United States / NCI NIH HHS / CO / N01-CO12400; United States / NIAID NIH HHS / AI / R56 AI064046; United States / NIAID NIH HHS / AI / AI39394; United States / NIAID NIH HHS / AI / K02 AI057735; United States / NCI NIH HHS / CA / N01CO12400; United States / NIGMS NIH HHS / GM / R01 GM056615; United States / NIAID NIH HHS / AI / R01 AI064046; United States / NIAID NIH HHS / AI / AI57735
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / DNA, Viral; 0 / Gene Products, vif; 0 / Repressor Proteins; 0 / vif Gene Products, Human Immunodeficiency Virus; 9014-25-9 / RNA, Transfer; EC 3.5.4.- / Nucleoside Deaminases; EC 3.5.4.5 / APOBEC3G protein, human; EC 3.5.4.5 / Cytidine Deaminase
  • [Other-IDs] NLM/ PMC1933301
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10. McQueen A, Swank PR, Bastian LA, Vernon SW: Predictors of perceived susceptibility of breast cancer and changes over time: a mixed modeling approach. Health Psychol; 2008 Jan;27(1):68-77
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  • [Title] Predictors of perceived susceptibility of breast cancer and changes over time: a mixed modeling approach.
  • OBJECTIVE: To examine predictors of perceived susceptibility to breast cancer and assess differences across three dependent measures.
  • Multivariable non-linear mixed model analyses examined individual- and group-level changes in perceived susceptibility to breast cancer.
  • DEPENDENT MEASURES: Three single-item measures of perceived susceptibility to breast cancer (percent risk, ordinal risk, and comparative risk likelihood).
  • RESULTS: Breast symptoms and greater cancer worry increased perceived susceptibility for all three measures.
  • CONCLUSION: Despite small model effect sizes, breast symptoms and cancer worry were consistent predictors and may be good targets for messages designed to influence women's perceived susceptibility to breast cancer.
  • Combining indicators of perceived susceptibility may be undesirable when different predictors are associated with different measures.

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  • (PMID = 18230016.001).
  • [ISSN] 0278-6133
  • [Journal-full-title] Health psychology : official journal of the Division of Health Psychology, American Psychological Association
  • [ISO-abbreviation] Health Psychol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA076330-02; United States / NCI NIH HHS / CA / R01 CA076330-02; United States / NCI NIH HHS / CA / R01 CA076330; United States / NCI NIH HHS / CA / CA057712-11A1; United States / NCI NIH HHS / CA / R25CA57712-11; United States / NCI NIH HHS / CA / R25 CA057712; United States / NCI NIH HHS / CA / R25 CA057712-11A1; United States / NCI NIH HHS / CA / R01CA76330
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS171633; NLM/ PMC2819176
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11. McTiernan A, Whelan J, Leahy M, Woll PJ: A Phase II Nonrandomised Open-Label Study of Liposomal Daunorubicin (DaunoXome) in Advanced Soft Tissue Sarcoma. Sarcoma; 2006;2006(1):41080
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  • In conclusion, DaunoXome at this dose and schedule is well tolerated in patients with advanced soft tissue sarcoma, but is not associated with significant activity.

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  • (PMID = 17040090.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC1510953
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12. Aiello-Laws L, Rutledge DN: Management of adult patients receiving intraventricular chemotherapy for the treatment of leptomeningeal metastasis. Clin J Oncol Nurs; 2008 Jun;12(3):429-35
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  • Cancer in the central nervous system can arise from a primary brain tumor and metastasize to the brain or to the leptomeninges, leading to leptomeningeal metastasis (LM).
  • Nursing care of patients with LM requires an understanding of neurologic anatomy and physiology, along with associated treatments and complications.
  • [MeSH-minor] Acquired Immunodeficiency Syndrome / complications. Adult. Blepharoptosis / etiology. Brain Neoplasms / pathology. Carcinoma / drug therapy. Carcinoma / nursing. Carcinoma / secondary. Drug Compounding. Drug Monitoring / nursing. Evidence-Based Medicine. Fatal Outcome. Humans. Low Back Pain / etiology. Lymphoma, AIDS-Related / complications. Male. Muscle Weakness / etiology. Nurse's Role. Nursing Assessment. Practice Guidelines as Topic

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  • (PMID = 18515241.001).
  • [ISSN] 1092-1095
  • [Journal-full-title] Clinical journal of oncology nursing
  • [ISO-abbreviation] Clin J Oncol Nurs
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 04079A1RDZ / Cytarabine
  • [Number-of-references] 30
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13. Shaffer AL, Emre NC, Romesser PB, Staudt LM: IRF4: Immunity. Malignancy! Therapy? Clin Cancer Res; 2009 May 1;15(9):2954-61
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  • [Title] IRF4: Immunity. Malignancy! Therapy?
  • IRF4 expression is also associated with many lymphoid malignancies, with recent evidence pointing to an essential role in multiple myeloma, a malignancy of plasma cells.

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  • (PMID = 19383829.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999; United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon Regulatory Factors; 0 / interferon regulatory factor-4
  • [Number-of-references] 87
  • [Other-IDs] NLM/ NIHMS161833; NLM/ PMC2790720
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1
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4. Xu C, Lo A, Yammanuru A, Tallarico AS, Brady K, Murakami A, Barteneva N, Zhu Q, Marasco WA: Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS One; 2010 Mar 10;5(3):e9625
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  • Besides the CA signal transduction activity, CAIX may serve as a biomarker in early stages of oncogenesis and also as a reliable marker of hypoxia, which is associated with tumor resistance to chemotherapy and radiotherapy.

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  • (PMID = 20224781.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NIDDK NIH HHS / DK / R21DK072282; United States / NIAID NIH HHS / AI / R21AI058804; United States / NCI NIH HHS / CA / P50 CA101942; United States / NIAID NIH HHS / AI / R21 AI058804; United States / NIDDK NIH HHS / DK / R21 DK072282; United States / NCRR NIH HHS / RR / S10 RR023459; United States / NCRR NIH HHS / RR / 1S10RR23459-01; United States / NCI NIH HHS / CA / 5P50CA101942
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Peptide Library; EC 4.2.1.1 / CA9 protein, human; EC 4.2.1.1 / Carbonic Anhydrases
  • [Other-IDs] NLM/ PMC2835754
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15. Majerciak V, Pripuzova N, McCoy JP, Gao SJ, Zheng ZM: Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus. J Virol; 2007 Feb;81(3):1062-71
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  • [Title] Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus.
  • Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 regulates viral gene expression at the posttranscriptional level during viral lytic infection.

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  • (PMID = 17108026.001).
  • [ISSN] 0022-538X
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / K8.1 protein, Human herpesvirus 8; 0 / ORF59 protein, Human herpesvirus 8; 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC1797518
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16. Jayadev S, Yun B, Nguyen H, Yokoo H, Morrison RS, Garden GA: The glial response to CNS HIV infection includes p53 activation and increased expression of p53 target genes. J Neuroimmune Pharmacol; 2007 Dec;2(4):359-70
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  • HIV-associated dementia (HAD) is a chronic neuroinflammatory disease that remains an important clinical problem without available rational treatment.
  • We have also shown that microglia from p53-deficient mice fail to induce neurotoxicity in response to the HIV coat protein gp120 in a coculture system, supporting the hypothesis that p53 plays a pathogenic role in the chronic neuroinflammatory component of HIV-associated neurodegeneration.
  • We analyzed the extent and cell type specificity of p53 accumulation in subcortical white matter of ten AIDS patients that had previously been shown to demonstrate white matter p53 accumulation.
  • [MeSH-major] AIDS Dementia Complex / genetics. AIDS Dementia Complex / metabolism. Central Nervous System Infections / metabolism. Gene Expression Regulation, Viral / physiology. Neuroglia / metabolism. Neuroglia / virology. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18040854.001).
  • [ISSN] 1557-1904
  • [Journal-full-title] Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
  • [ISO-abbreviation] J Neuroimmune Pharmacol
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS35533; United States / NICHD NIH HHS / HD / P30-HD02774; United States / NIA NIH HHS / AG / T32-AG000268; United States / NINDS NIH HHS / NS / NS45528; United States / NIMH NIH HHS / MH / U01 MH083545; United States / NIMH NIH HHS / MH / N01MH32002
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
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17. Mitton-Fry RM, DeGregorio SJ, Wang J, Steitz TA, Steitz JA: Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science; 2010 Nov 26;330(6008):1244-7
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  • Kaposi's sarcoma-associated herpesvirus produces a highly abundant, nuclear noncoding RNA, polyadenylated nuclear (PAN) RNA, which contains an element that prevents its decay.

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  • (PMID = 21109672.001).
  • [ISSN] 1095-9203
  • [Journal-full-title] Science (New York, N.Y.)
  • [ISO-abbreviation] Science
  • [Language] eng
  • [Databank-accession-numbers] PDB/ 3P22
  • [Grant] United States / NCI NIH HHS / CA / CA16038; United States / NCI NIH HHS / CA / P01 CA016038-38; United States / Howard Hughes Medical Institute / / ; United States / NIBIB NIH HHS / EB / P30 EB009998; United States / NIGMS NIH HHS / GM / P01 GM022778; United States / NCI NIH HHS / CA / P01 CA016038; United States / NIGMS NIH HHS / GM / GM022778; United States / NIGMS NIH HHS / GM / R01 GM026154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / RNA, Nuclear; 0 / RNA, Untranslated; 0 / RNA, Viral; 0 / Regulatory Sequences, Ribonucleic Acid; 0 / Riboswitch; 24937-83-5 / Poly A
  • [Other-IDs] NLM/ NIHMS287168; NLM/ PMC3074936
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18. Sathekge M, Goethals I, Maes A, van de Wiele C: Positron emission tomography in patients suffering from HIV-1 infection. Eur J Nucl Med Mol Imaging; 2009 Jul;36(7):1176-84
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  • This paper reviews currently available PET studies performed either to improve our understanding of the pathogenesis of HIV-1 infection or to assess the value of PET imaging in the clinical decision making of patients infected with HIV-1 presenting with AIDS-related opportunistic infections and malignancies.
  • In lipodystrophic HIV-infected patients, limited available data support the hypothesis that stavudine-related lipodystrophy is associated with increased glucose uptake by adipose tissue as a result of the metabolic stress of adipose tissue in response to highly active antiretroviral treatment (HAART).
  • Finally, in early AIDS-related dementia complex (ADC), striatal hypermetabolism is observed, whereas progressive ADC is characterized by a decrease in subcortical and cortical metabolism.
  • In the clinical setting, PET has been shown to allow the differentiation of AIDS-related opportunistic infections and malignancies, and to allow monitoring of side effects of HAART.
  • However, in patients suffering from HIV infection and presenting with extracerebral lymphoma or other human malignancies, knowledge of viraemia is essential when interpreting FDG PET imaging.

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  • (PMID = 19350235.001).
  • [ISSN] 1619-7089
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 63
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19. Costelli P, Reffo P, Penna F, Autelli R, Bonelli G, Baccino FM: Ca(2+)-dependent proteolysis in muscle wasting. Int J Biochem Cell Biol; 2005 Oct;37(10):2134-46
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  • Skeletal muscle wasting is a prominent feature of cachexia, a complex systemic syndrome that frequently complicates chronic diseases such as inflammatory and autoimmune disorders, cancer and AIDS.
  • Modulations of Ca(2+)-dependent proteolysis have been associated with muscle protein depletion in various pathological contexts and particularly with muscle dystrophies.

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  • (PMID = 15893952.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Muscle Proteins; 0 / Ubiquitins; EC 3.4.22.- / Calpain; EC 3.4.25.1 / Proteasome Endopeptidase Complex; SY7Q814VUP / Calcium
  • [Number-of-references] 128
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20. Van Duyne R, Pedati C, Guendel I, Carpio L, Kehn-Hall K, Saifuddin M, Kashanchi F: The utilization of humanized mouse models for the study of human retroviral infections. Retrovirology; 2009 Aug 12;6:76
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  • The implantation of uneducated human immune cells and associated tissue provided the basis for the SCID-hu Thy/Liv and hu-PBL-SCID models.

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  • (PMID = 19674458.001).
  • [ISSN] 1742-4690
  • [Journal-full-title] Retrovirology
  • [ISO-abbreviation] Retrovirology
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R21 AI071903; United States / NIAID NIH HHS / AI / AI071903-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Rag2 protein, mouse
  • [Number-of-references] 163
  • [Other-IDs] NLM/ PMC2743631
  •  go-up   go-down


26. Majerciak V, Kruhlak M, Dagur PK, McCoy JP Jr, Zheng ZM: Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression. J Biol Chem; 2010 Apr 9;285(15):11297-307
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  • [Title] Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
  • Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a viral early protein essential for KSHV multiplication.

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  • (PMID = 20159985.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amino Acid Chloromethyl Ketones; 0 / RNA, Small Interfering; 0 / RNA, Viral; 0 / Viral Proteins; 0 / benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspase 7
  • [Other-IDs] NLM/ PMC2857008
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27. Sherman DW, Ye XY, McSherry C, Parkas V, Calabrese M, Gatto M: Quality of life of patients with advanced cancer and acquired immune deficiency syndrome and their family caregivers. J Palliat Med; 2006 Aug;9(4):948-63
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  • [Title] Quality of life of patients with advanced cancer and acquired immune deficiency syndrome and their family caregivers.
  • (1) establish the reliability of multidimensional quality of life instruments based on patients with acquired immune deficiency syndrome (AIDS) and patients with cancer and caregivers;.
  • (2) identify differences in quality of life between patients with advanced AIDS and cancer, and their family caregivers with consideration of mortality, attrition, and compliance rates; and (3) examine differences in demographic variables and their potential confounding effect when measuring quality of life.
  • METHODS: The sample included 101 patients with advanced illness (63 patients with advanced AIDS and 38 with advanced cancer) and 81 family caregivers (43 caregivers for patients with AIDS and 38 caregivers for patients with cancer).
  • RESULTS: Reliability of the MQOL and QLS were established for patients with AIDS and patients with cancer and caregivers.
  • Based on the MQOL, patients with advanced AIDS reported a lower total quality of life, and lower psychological quality of life, and a higher physical quality of life compared to patients with advanced cancer.
  • Based on the QLS, AIDS caregivers reported greater overall quality of life, greater psychological well-being, and greater spiritual well-be- ing than cancer caregivers.
  • There were no significant differences between AIDS and cancer caregivers with respect to physical or social well-being.
  • Fourteen of 63 (22%) patients with AIDS patients died, while 19 of 38 (50%) patients with advanced cancer died after enrollment.
  • Forty-six of 63 (73%) patients with advanced AIDS withdrew for various reasons other than death at some point during the 12 month time frame of the study, while 15 of 38 (39%) patients with advanced cancer withdrew.
  • There were significant differences on all demographic variables for patients with advanced cancer and AIDS.
  • Only religious affiliation was significantly related to quality of life for patients with AIDS, while gender was the only variable associated with quality of life for patients with cancer.
  • Only the relationship between patients and caregivers and marital status were significantly associated with quality of life for cancer caregivers.


28. Galea S, Rudenstine S: Challenges in understanding disparities in drug use and its consequences. J Urban Health; 2005 Jun;82(2 Suppl 3):iii5-12
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  • For example, Blacks have higher HIV incidence and AIDS-related mortality than do Whites.
  • (b) racial/ethnic differences in use of drugs are not always associated with comparable differences in the consequences of drug use; and (c) the consequences of drug use are associated with drug use itself and other social/economic circumstances.

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  • (PMID = 15933331.001).
  • [ISSN] 1099-3460
  • [Journal-full-title] Journal of urban health : bulletin of the New York Academy of Medicine
  • [ISO-abbreviation] J Urban Health
  • [Language] ENG
  • [Grant] United States / NIDA NIH HHS / DA / DA 013146-S1; United States / NIDA NIH HHS / DA / DA 017642; United States / NIDA NIH HHS / DA / DA 018061
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] United States
  • [Number-of-references] 48
  • [Other-IDs] NLM/ PMC3455901
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29. Thammavongsa V, Schaefer M, Filzen T, Collins KL, Carrington M, Bangia N, Raghavan M: Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503. Immunogenetics; 2009 Dec;61(11-12):703-16
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  • Residue 116 of major histocompatibility complex (MHC) class I heavy chains is an important determinant of assembly, that can influence rates of ER-Golgi trafficking, binding to the transporter associated with antigen processing (TAP), tapasin dependence of assembly, and the efficiency and specificity of peptide binding.
  • Here, we investigated assembly and peptide-binding differences between HLA-B*3501(S116) and HLA-B*3503(F116), two alleles differing only at position 116 of the MHC class I heavy chain, that are associated respectively with normal or rapid AIDS progression.
  • These findings suggest that compared to HLA-B*3501, a reduced intracellular peptide repertoire for HLA-B*3503 could contribute to its slower intracellular trafficking and stronger association with rapid AIDS progression.

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  • (PMID = 19838694.001).
  • [ISSN] 1432-1211
  • [Journal-full-title] Immunogenetics
  • [ISO-abbreviation] Immunogenetics
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI044115; United States / NIAID NIH HHS / AI / AI44155; United States / NIAID NIH HHS / AI / R01 AI044115-01; United States / CCR NIH HHS / RC / HHSN261200800001C; United States / NCI NIH HHS / CA / HHSN261200800001E
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ATP-Binding Cassette Sub-Family B Member 2; 0 / ATP-Binding Cassette Transporters; 0 / HLA-B Antigens; 0 / HLA-B*35:01 antigen; 0 / HLA-B35 Antigen; 0 / Membrane Transport Proteins; 0 / Peptides; 0 / TAP1 protein, human; 0 / tapasin
  • [Other-IDs] NLM/ NIHMS155775; NLM/ PMC2971690
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30. Insinga RP, Dasbach EJ, Elbasha EH: Assessing the annual economic burden of preventing and treating anogenital human papillomavirus-related disease in the US: analytic framework and review of the literature. Pharmacoeconomics; 2005;23(11):1107-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessing the annual economic burden of preventing and treating anogenital human papillomavirus-related disease in the US: analytic framework and review of the literature.
  • Comprehensive estimates of the annual economic burden associated with the prevention and treatment of anogenital HPV-related disease in the US population are currently unavailable.
  • The purpose of this paper is to (i) outline an analytic framework from which to estimate the annual economic burden of preventing and treating anogenital HPV-related disease in the US;.
  • Among eight US studies identified that describe the annual economic burden pertaining to one or more aspects of anogenital HPV-related disease, three met the review eligibility criteria (published between 1990 and 2004, examined multiple facets of annual anogenital HPV-related economic burden, and clearly articulated the data and methods used in the estimation process).
  • Estimates of the annual direct medical costs associated with cervical cancer were comparable across studies (range 300-400 million US dollars).
  • In contrast, there was a wide range across studies for estimates of the annual direct medical costs associated with cervical intraepithelial neoplasia (range 700 million US dollars-2.3 billion US dollars).
  • Only one study reported direct medical costs for anogenital warts (200 million US dollars) and routine cervical cancer screening (2.3 billion US dollars).
  • No studies examined direct medical costs attributable to HPV-related anal, penile, vaginal or vulvar cancers, or the work and productivity losses resulting from time spent receiving medical care, morbidity or mortality.
  • Current economic burden estimates would suggest annual direct medical costs associated with the prevention and treatment of anogenital warts and cervical HPV-related disease of at least 4 billion US dollars.
  • This figure would likely rise to at least 5 billion US dollars per year if direct medical costs associated with other disease entities caused by the sexual transmission of HPV were included, with further additions to the economic burden totalling in the billions of dollars if work and productivity losses were incorporated, a research priority for future studies.


31. Richard J, Sindhu S, Pham TN, Belzile JP, Cohen EA: HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing. Blood; 2010 Feb 18;115(7):1354-63
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  • Delivery of virion-associated Vpr via defective HIV-1 particles induced analogous biologic effects in noninfected target cells, suggesting that Vpr may act similarly beyond infected cells.

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  • (PMID = 20008788.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] None / None / / 12381-4; Canada / Canadian Institutes of Health Research / / 12381-4; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / GPI-Linked Proteins; 0 / Immunologic Factors; 0 / Intercellular Signaling Peptides and Proteins; 0 / KLRK1 protein, human; 0 / Ligands; 0 / NK Cell Lectin-Like Receptor Subfamily K; 0 / Receptors, Cell Surface; 0 / ULBP2 protein, human; 0 / vpr Gene Products, Human Immunodeficiency Virus; 0 / vpr protein, Human immunodeficiency virus 1; EC 2.7.11.1 / ATR protein, human; EC 2.7.11.1 / Ataxia Telangiectasia Mutated Proteins; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ CAMS4124; NLM/ PMC3955183
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32. Reinhart TA, Qin S, Sui Y: Multiple roles for chemokines in the pathogenesis of SIV infection. Curr HIV Res; 2009 Jan;7(1):73-82
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  • The complex immunobiology of chemokines, coupled with the use of subsets of chemokine receptors as HIV-1 and SIV entry co-receptors, suggests that these immunomodulators could play important roles in the pathogenesis associated with infection by HIV-1 or SIV.

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  • (PMID = 19149556.001).
  • [ISSN] 1873-4251
  • [Journal-full-title] Current HIV research
  • [ISO-abbreviation] Curr. HIV Res.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI060422; United States / NIAID NIH HHS / AI / AI060422
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Chemokines
  • [Number-of-references] 182
  • [Other-IDs] NLM/ PMC3580803
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33. Falchi L, Capello D, Palumbo B, Rauco A, Emili R, Cianciulli M, Pace R, Capparella V, Liberati F, Liberati AM: A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy. Eur J Haematol; 2007 Nov;79(5):455-61
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  • We report the case of an Epstein-Barr virus (EBV)- and human immunodeficiency virus-serum negative patient suffering from repeatedly relapsing classical Hodgkin's Lymphoma (cHL) associated with a histological picture of plasma cell-hyaline vascular (PC-HV) form of Castleman's disease (CD).

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  • (PMID = 17908180.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Antineoplastic Agents; 0 / Immunologic Factors; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 4F4X42SYQ6 / Rituximab
  • [Other-IDs] NLM/ PMC2121125
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34. Yang I, Tihan T, Han SJ, Wrensch MR, Wiencke J, Sughrue ME, Parsa AT: CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival. J Clin Neurosci; 2010 Nov;17(11):1381-5
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  • [Title] CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival.
  • Here we investigate whether the extent of local glioma-associated CD8+ T-cell infiltrate at initial presentation correlates with long-term survival in patients with glioblastoma multiforme (GBM).
  • Thus, CD8+ T-cell infiltrate is associated with prolonged survival.
  • Our data provide the impetus for more sophisticated studies to further elucidate prospectively the specific T-cell subtypes associated with long-term survival.

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  • [Copyright] Copyright © 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20727764.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / F32 CA132489; United States / NCI NIH HHS / CA / R01 CA052689; United States / NCI NIH HHS / CA / F32 CA132489-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Other-IDs] NLM/ NIHMS230845; NLM/ PMC3064460
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35. Delviks-Frankenberry KA, Nikolenko GN, Maldarelli F, Hase S, Takebe Y, Pathak VK: Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine. J Virol; 2009 Sep;83(17):8502-13
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  • [Title] Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.
  • The high level of AZT resistance exhibited by CRF01_AE was primarily associated with the T400 residue in wild-type subtype AE CN subdomain.
  • These results show for the first time that CRF01_AE exhibits higher levels of AZT resistance in the presence of TAMs and that this resistance is primarily associated with T400.

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  • (PMID = 19553318.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / RNA, Viral; 0 / Viral Proteins; 4B9XT59T7S / Zidovudine; EC 2.7.7.- / reverse transcriptase, Human immunodeficiency virus 1; EC 2.7.7.49 / HIV Reverse Transcriptase; EC 3.1.26.4 / Ribonuclease H; VC2W18DGKR / Thymidine
  • [Other-IDs] NLM/ PMC2738196
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36. Nawar E, Mbulaiteye SM, Gallant JE, Wohl DA, Ardini M, Hendershot T, Goedert JJ, Rabkin CS, AIDS Cancer Cohort (ACC) Study Collaborators: Risk factors for Kaposi's sarcoma among HHV-8 seropositive homosexual men with AIDS. Int J Cancer; 2005 Jun 10;115(2):296-300
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  • [Title] Risk factors for Kaposi's sarcoma among HHV-8 seropositive homosexual men with AIDS.
  • Kaposi's sarcoma (KS) is a frequent complication of the acquired immunodeficiency syndrome (AIDS) in homosexual men.
  • Risk factors for developing this malignancy are uncertain, other than immunosuppression and coinfection with human herpesvirus 8 (HHV-8).
  • We therefore examined factors associated with KS in a cross-sectional analysis of 99 cases among 503 HHV-8 seropositive homosexual men with AIDS.
  • KS was less common in bisexual men compared to men who were exclusively homosexual (estimated RR = 0.6; 95% CI = 0.4-0.9) and inversely associated with number of female partners.

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  • (PMID = 15688390.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CO / N01-CO-12400; United States / NCI NIH HHS / CP / N01-CP-81017
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / K8.1 protein, Human herpesvirus 8; 0 / Viral Proteins
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37. Katano H, Sato Y, Hoshino S, Tachikawa N, Oka S, Morishita Y, Ishida T, Watanabe T, Rom WN, Mori S, Sata T, Weiden MD, Hoshino Y: Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient. Microbes Infect; 2007 Nov-Dec;9(14-15):1581-9
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  • [Title] Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.
  • High expression of STAT3 has also been implicated in cancer and lymphoma.
  • The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of an acquired immunodeficiency syndrome (AIDS) patient with Kaposi's sarcoma.

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  • [ISSN] 1286-4579
  • [Journal-full-title] Microbes and infection
  • [ISO-abbreviation] Microbes Infect.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000096; United States / NIDA NIH HHS / DA / R21 DA022162-02; United States / NCRR NIH HHS / RR / MO1 RR00096; United States / NIDA NIH HHS / DA / R21 DA022162-01; United States / NIDA NIH HHS / DA / DA022162; United States / NIDA NIH HHS / DA / DA022162-01; United States / NHLBI NIH HHS / HL / HL 59832; United States / NHLBI NIH HHS / HL / R01 HL059832; United States / NIDA NIH HHS / DA / DA022162-02; United States / NIDA NIH HHS / DA / R21 DA022162; United States / NHLBI NIH HHS / HL / HL57879; United States / NHLBI NIH HHS / HL / R01 HL057879
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / DNA, Viral; 0 / STAT3 Transcription Factor
  • [Other-IDs] NLM/ NIHMS36353; NLM/ PMC2200298
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38. Smith JS, Rosinska M, Trzcinska A, Pimenta JM, Litwinska B, Siennicka J: Type specific seroprevalence of HSV-1 and HSV-2 in four geographical regions of Poland. Sex Transm Infect; 2006 Apr;82(2):159-63
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  • OBJECTIVE: To examine the type specific seroprevalence of herpes simplex virus (HSV) types 1 and 2 infections, stratified by age and gender, and associated risk factors for HSV-2 seropositivity in Poland.

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  • (PMID = 16581747.001).
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  • [Journal-full-title] Sexually transmitted infections
  • [ISO-abbreviation] Sex Transm Infect
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2564693
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39. Minang JT, Trivett MT, Coren LV, Barsov EV, Piatak M Jr, Ott DE, Ohlen C: Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8(+) T cells independent of IFN-gamma and CD107a responses. Virology; 2009 Aug 15;391(1):130-9
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  • CTL antiviral activity is dependent on recognition of antigenic peptides associated with MHC class I molecules on infected target cells, and CTL activation can be impaired by Nef-mediated down-regulation of MHC class I molecules.

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  • (PMID = 19555986.001).
  • [ISSN] 1096-0341
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / / Z99 CA999999; United States / PHS HHS / / HHSN261200800001E; United States / NCI NIH HHS / CA / N01CO12400; United States / CCR NIH HHS / RC / HHSN261200800001C; United States / NCI NIH HHS / CO / N01-CO-12400; United States / NCI NIH HHS / CA / HHSN261200800001E
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gene Products, nef; 0 / Histocompatibility Antigens Class I; 0 / Lysosomal-Associated Membrane Protein 1; 0 / RNA, Viral; 82115-62-6 / Interferon-gamma
  • [Other-IDs] NLM/ NIHMS122691; NLM/ PMC2716421
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40. Petrovsky N: Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Vaccine; 2006 Apr 12;24 Suppl 2:S2-26-9
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  • Despite the enormous number of candidates, potency has invariably been associated with increased toxicity, and this more than anything else has precluded their use, particularly in prophylactic vaccines where safety issues are paramount.
  • Thus, adjuvants based on inulin have enormous potential for use in vaccines against both pathogens and cancer.

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  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / U01 AI061142; United States / NIAID NIH HHS / AI / U01 AI061142-05
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 9005-80-5 / Inulin
  • [Number-of-references] 28
  • [Other-IDs] NLM/ NIHMS295863; NLM/ PMC3101117
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41. Al-Harthi L, Voris J, Du W, Wright D, Nowicki M, Frederick T, Landay A, Kovacs A: Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells. J Infect Dis; 2006 May 01;193(9):1202-10
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  • HIV/HCV coinfection is associated with an increased number of CD4+ and CD8+ primed/memory T cells.
  • CONCLUSIONS: HCV does not affect immune responses to HAART in HIV/HCV-coinfected individuals but is associated with an expansion of CD4+ and CD8+ memory T cell subsets.

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  • (PMID = 16586355.001).
  • [ISSN] 0022-1899
  • [Journal-full-title] The Journal of infectious diseases
  • [ISO-abbreviation] J. Infect. Dis.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000079; United States / NIAID NIH HHS / AI / U01-AI-42590; United States / NIAID NIH HHS / AI / U01 AI031834; United States / NIAID NIH HHS / AI / R56 AI052065; United States / NIAID NIH HHS / AI / U01 AI035004; United States / NICHD NIH HHS / HD / U01-HD-32632; United States / NIAID NIH HHS / AI / U01 AI034989; United States / NIAID NIH HHS / AI / R01 AI052065; United States / NCRR NIH HHS / RR / M01-RR-00083; United States / NIAID NIH HHS / AI / R01 AI052065-01; United States / NCRR NIH HHS / RR / M01 RR000071; United States / NIAID NIH HHS / AI / U01-AI-34994; United States / NIAID NIH HHS / AI / U01-AI-35004; United States / NIAID NIH HHS / AI / U01-AI-31834; United States / NCRR NIH HHS / RR / M01-RR-00079; United States / NIAID NIH HHS / AI / U01 AI034994; United States / NICHD NIH HHS / HD / U01-HD-3-2632-11; United States / NIAID NIH HHS / AI / U01-AI-34993; United States / NCRR NIH HHS / RR / M01-RR-00071; United States / NIAID NIH HHS / AI / U01 AI034993; United States / NCRR NIH HHS / RR / M01 RR000083; United States / NIAID NIH HHS / AI / U01-AI-34989; United States / NICHD NIH HHS / HD / U01 HD032632; United States / NIAID NIH HHS / AI / U01 AI042590; United States / PHS HHS / / R01 052065
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Antigens, CD; 0 / Biomarkers
  • [Other-IDs] NLM/ NIHMS300010; NLM/ PMC3126663
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42. Keele BF, Tazi L, Gartner S, Liu Y, Burgon TB, Estes JD, Thacker TC, Crandall KA, McArthur JC, Burton GF: Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1. J Virol; 2008 Jun;82(11):5548-61
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  • Throughout the natural course of human immunodeficiency virus (HIV) infection, follicular dendritic cells (FDCs) trap and retain large quantities of particle-associated HIV RNA in the follicles of secondary lymphoid tissue.

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  • (PMID = 18385252.001).
  • [ISSN] 1098-5514
  • [Journal-full-title] Journal of virology
  • [ISO-abbreviation] J. Virol.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / AI57007; United States / NIAID NIH HHS / AI / R01 AI057007; United States / NIAID NIH HHS / AI / R21 AI039963; United States / NIAID NIH HHS / AI / R56 AI039963; United States / NIAID NIH HHS / AI / AI39963; United States / NIAID NIH HHS / AI / R01 AI039963; United States / NIGMS NIH HHS / GM / GM66276; United States / NIGMS NIH HHS / GM / R01 GM066276
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC2395176
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43. Bodaghi S, Wood LV, Roby G, Ryder C, Steinberg SM, Zheng ZM: Could human papillomaviruses be spread through blood? J Clin Microbiol; 2005 Nov;43(11):5428-34
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  • HPV infection through abrasion of the skin or sexual intercourse causes benign warts and sometimes cancer.
  • HPV DNA detected in the blood has been interpreted as having originated from metastasized cancer cells.
  • Among the eight patients, seven acquired HIV from transfusion (three associated with hemophilia) and one acquired HIV through vertical transmission; this patient also had received a transfusion before sampling.

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  • (PMID = 16272465.001).
  • [ISSN] 0095-1137
  • [Journal-full-title] Journal of clinical microbiology
  • [ISO-abbreviation] J. Clin. Microbiol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / SC / Z01 SC010357-06; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Other-IDs] NLM/ PMC1287818
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44. Moursi AM, Fernandez JB, Daronch M, Zee L, Jones CL: Nutrition and oral health considerations in children with special health care needs: implications for oral health care providers. Pediatr Dent; 2010 Jul-Aug;32(4):333-42
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  • The purpose of this article was to discuss: nutritional and oral health factors routinely observed in most chronic childhood disorders; dietary modifications associated with select systemic disorders and how they may impact oral health in children; and the following factors common to chronic disorders associated with diet modifications-decreased appetite and increased nutritional risk; frequency of food intake; parental overindulgence; long-term use of cariogenic medications; and xerostomia.
  • Characteristics of childhood disorders that require dietary modifications (congenital heart disease, cystic fibrosis, cancer, AIDS/HIV, diabetes mellitus, and phenylketonuria) are summarized.


45. Olivieri KC, Agopian KA, Mukerji J, Gabuzda D: Evidence for adaptive evolution at the divergence between lymphoid and brain HIV-1 nef genes. AIDS Res Hum Retroviruses; 2010 Apr;26(4):495-500
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  • Human immunodeficiency virus type 1 (HIV) infection of the central nervous system frequently causes HIV-associated neurocognitive disorders (HAND).
  • To determine whether HIV nef undergoes adaptive selection in brain, we cloned 100 nef sequences (n = 30 brain and n = 70 lymphoid) from four patients with AIDS and HIV-associated dementia (HAD).

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  • [ISSN] 1931-8405
  • [Journal-full-title] AIDS research and human retroviruses
  • [ISO-abbreviation] AIDS Res. Hum. Retroviruses
  • [Language] ENG
  • [Databank-accession-numbers] GENBANK/ DQ358015/ DQ358016/ DQ358017/ DQ358018/ DQ358019/ DQ358020/ DQ358021/ DQ358022/ DQ358023/ DQ358024/ DQ358025/ DQ358026/ DQ358027/ DQ358028/ DQ358029/ DQ358030/ DQ358031/ DQ358032/ DQ358033/ DQ358034/ DQ358035/ DQ358036/ DQ358037/ DQ358038/ DQ358039/ DQ358040/ DQ358041/ DQ358042/ DQ358043/ DQ358044/ DQ358045/ DQ358046/ DQ358047/ DQ885391/ DQ885392/ DQ885393/ DQ885394/ DQ885395/ DQ885396/ DQ885397/ DQ885398/ DQ885399/ DQ885400/ DQ885401/ DQ885402/ DQ885403/ DQ885404/ DQ885405/ DQ885406/ DQ885407/ DQ885408/ DQ885409/ DQ885410/ DQ885411/ DQ885412/ DQ885413/ DQ885414/ DQ885415/ DQ885416/ DQ885417/ DQ885418/ DQ885419/ DQ885420/ DQ885421/ DQ885422/ DQ885423/ DQ885424/ DQ885425/ DQ885426/ DQ885427/ DQ885428/ DQ885429/ DQ885430/ DQ885431/ DQ885432/ DQ885433/ DQ885434/ DQ885435/ DQ885436/ DQ885437/ DQ885438/ DQ885439/ DQ885440/ DQ885441/ DQ885442/ DQ885443/ DQ885444/ DQ885445/ DQ885446/ DQ885447/ DQ885448/ DQ885449/ DQ885450/ DQ885451/ DQ885452/ DQ885453/ DQ885454/ GU049621/ GU049622/ GU049623/ GU049624/ GU049625/ GU049626/ GU049627/ GU049628/ GU049629/ GU049630/ GU049631/ GU049632/ GU049633/ GU049634/ GU049635/ GU049636/ GU049637/ GU049638/ GU049639/ GU049640/ GU049641/ GU049642/ GU049643/ GU049644/ GU049645/ GU049646/ GU049647/ GU049648/ GU049649/ GU049650/ GU049651/ GU049652/ GU049653/ GU049654/ GU049655/ GU049656/ GU049657/ GU049658/ GU049659
  • [Grant] United States / NIA NIH HHS / AG / T32 AG00222; United States / NIAID NIH HHS / AI / AI073415-02; United States / NIMH NIH HHS / MH / MH083588-10A2; United States / NIMH NIH HHS / MH / R01 MH083588; United States / NIMH NIH HHS / MH / MH083588-11; United States / NIMH NIH HHS / MH / MH83588; United States / NIMH NIH HHS / MH / MH083588-12; United States / NIAID NIH HHS / AI / AI073415-01A2; United States / NIMH NIH HHS / MH / R01 MH083588-10A2; United States / NIAID NIH HHS / AI / R21 AI073415-01A2; United States / NIMH NIH HHS / MH / R01 MH083588-11; United States / NIAID NIH HHS / AI / R21 AI073415-02; United States / NIMH NIH HHS / MH / R01 MH083588-12; United States / NIAID NIH HHS / AI / T32 AI007386; United States / NIAID NIH HHS / AI / AI73415; United States / NIAID NIH HHS / AI / R21 AI073415
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / nef Gene Products, Human Immunodeficiency Virus; 0 / nef protein, Human immunodeficiency virus 1
  • [Other-IDs] NLM/ PMC2933169
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46. Longmire-Avital B, Golub SA, Parsons JT: Self-reevaluation as a critical component in sustained viral load change for HIV+ adults with alcohol problems. Ann Behav Med; 2010 Oct;40(2):176-83
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  • Although self-reevaluation is a critical motivator for individuals in the contemplation stage of change, few studies have examined its impact on disease progression associated with sustained behavior change.

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  • (PMID = 20668976.001).
  • [ISSN] 1532-4796
  • [Journal-full-title] Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
  • [ISO-abbreviation] Ann Behav Med
  • [Language] ENG
  • [Grant] United States / NIAAA NIH HHS / AA / R01 AA013556; United States / NIDA NIH HHS / DA / T32 DA007233; United States / NIDA NIH HHS / DA / 5T32 DA07233; United States / NIAAA NIH HHS / AA / R01 AA13556
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS223034; NLM/ PMC2939147
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47. Luchters SM, Vanden Broeck D, Chersich MF, Nel A, Delva W, Mandaliya K, Depuydt CE, Claeys P, Bogers JP, Temmerman M: Association of HIV infection with distribution and viral load of HPV types in Kenya: a survey with 820 female sex workers. BMC Infect Dis; 2010;10:18
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  • HPV 16 and HPV 18, preventable with current vaccines, were associated with cervical disease, though other high-risk types were commoner.

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  • (PMID = 20102630.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2845133
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48. Krown SE, Lee JY, Lin L, Fischl MA, Ambinder R, Von Roenn JH: Interferon-alpha2b with protease inhibitor-based antiretroviral therapy in patients with AIDS-associated Kaposi sarcoma: an AIDS malignancy consortium phase I trial. J Acquir Immune Defic Syndr; 2006 Feb 1;41(2):149-53
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  • [Title] Interferon-alpha2b with protease inhibitor-based antiretroviral therapy in patients with AIDS-associated Kaposi sarcoma: an AIDS malignancy consortium phase I trial.
  • We evaluated the safety and maximum tolerated dose of interferon (IFN)-alpha2b in combination with protease inhibitor-based highly active antiretroviral therapy (HAART) in a phase 1 study in 14 patients with AIDS-associated Kaposi sarcoma (KS).
  • [MeSH-major] AIDS-Related Opportunistic Infections / drug therapy. Antiviral Agents / therapeutic use. HIV Protease Inhibitors / therapeutic use. Herpesvirus 8, Human. Interferon-alpha / therapeutic use. Sarcoma, Kaposi / drug therapy

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  • (PMID = 16394845.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / UO1-CA70081; United States / NCI NIH HHS / CA / UO1-CA71375; United States / NCI NIH HHS / CA / UO1CA70019; United States / NCI NIH HHS / CA / UO1CA70047; United States / NCI NIH HHS / CA / UO1CA70054; United States / NCI NIH HHS / CA / UO1CA70062; United States / NCI NIH HHS / CA / UO1CA70068; United States / NCI NIH HHS / CA / UO1CA70080
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / HIV Protease Inhibitors; 0 / Interferon-alpha; 0 / Recombinant Proteins; 99210-65-8 / interferon alfa-2b
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49. DART Trial Team, Mugyenyi P, Walker AS, Hakim J, Munderi P, Gibb DM, Kityo C, Reid A, Grosskurth H, Darbyshire JH, Ssali F, Bray D, Katabira E, Babiker AG, Gilks CF, Grosskurth H, Munderi P, Kabuye G, Nsibambi D, Kasirye R, Zalwango E, Nakazibwe M, Kikaire B, Nassuna G, Massa R, Fadhiru K, Namyalo M, Zalwango A, Generous L, Khauka P, Rutikarayo N, Nakahima W, Mugisha A, Todd J, Levin J, Muyingo S, Ruberantwari A, Kaleebu P, Yirrell D, Ndembi N, Lyagoba F, Hughes P, Aber M, Lara AM, Foster S, Amurwon J, Wakholi BN, Whitworth J, Wangati K, Amuron B, Kajungu D, Nakiyingi J, Omony W, Fadhiru K, Nsibambi D, Khauka P, Mugyenyi P, Kityo C, Ssali F, Tumukunde D, Otim T, Kabanda J, Musana H, Akao J, Kyomugisha H, Byamukama A, Sabiiti J, Komugyena J, Wavamunno P, Mukiibi S, Drasiku A, Byaruhanga R, Labeja O, Katundu P, Tugume S, Awio P, Namazzi A, Bakeinyaga GT, Katabira H, Abaine D, Tukamushaba J, Anywar W, Ojiambo W, Angweng E, Murungi S, Haguma W, Atwiine S, Kigozi J, Namale L, Mukose A, Mulindwa G, Atwiine D, Muhwezi A, Nimwesiga E, Barungi G, Takubwa J, Murungi S, Mwebesa D, Kagina G, Mulindwa M, Ahimbisibwe F, Mwesigwa P, Akuma S, Zawedde C, Nyiraguhirwa D, Tumusiime C, Bagaya L, Namara W, Kigozi J, Karungi J, Kankunda R, Enzama R, Latif A, Hakim J, Robertson V, Reid A, Chidziva E, Bulaya-Tembo R, Musoro G, Taziwa F, Chimbetete C, Chakonza L, Mawora A, Muvirimi C, Tinago G, Svovanapasis P, Simango M, Chirema O, Machingura J, Mutsai S, Phiri M, Bafana T, Chirara M, Muchabaiwa L, Muzambi M, Mutowo J, Chivhunga T, Chigwedere E, Pascoe M, Warambwa C, Zengeza E, Mapinge F, Makota S, Jamu A, Ngorima N, Chirairo H, Chitsungo S, Chimanzi J, Maweni C, Warara R, Matongo M, Mudzingwa S, Jangano M, Moyo K, Vere L, Mdege N, Machingura I, Katabira E, Ronald A, Kambungu A, Lutwama F, Mambule I, Nanfuka A, Walusimbi J, Nabankema E, Nalumenya R, Namuli T, Kulume R, Namata I, Nyachwo L, Florence A, Kusiima A, Lubwama E, Nairuba R, Oketta F, Buluma E, Waita R, Ojiambo H, Sadik F, Wanyama J, Nabongo P, Oyugi J, Sematala F, Muganzi A, Twijukye C, Byakwaga H, Ochai R, Muhweezi D, Coutinho A, Etukoit B, Gilks C, Boocock K, Puddephatt C, Grundy C, Bohannon J, Winogron D, Gibb DM, Burke A, Bray D, Babiker A, Walker AS, Wilkes H, Rauchenberger M, Sheehan S, Spencer-Drake C, Taylor K, Spyer M, Ferrier A, Naidoo B, Dunn D, Goodall R, Darbyshire JH, Peto L, Nanfuka R, Mufuka-Kapuya C, Kaleebu P, Pillay D, Robertson V, Yirrell D, Tugume S, Chirara M, Katundu P, Ndembi N, Lyagoba F, Dunn D, Goodall R, McCormick A, Lara AM, Foster S, Amurwon J, Wakholi BN, Kigozi J, Muchabaiwa L, Muzambi M, Weller I, Babiker A, Bahendeka S, Bassett M, Wapakhabulo AC, Darbyshire JH, Gazzard B, Gilks C, Grosskurth H, Hakim J, Latif A, Mapuchere C, Mugurungi O, Mugyenyi P, Burke C, Jones S, Newland C, Pearce G, Rahim S, Rooney J, Smith M, Snowden W, Steens JM, Breckenridge A, McLaren A, Hill C, Matenga J, Pozniak A, Serwadda D, Peto T, Palfreeman A, Borok M, Katabira E: Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet; 2010 Jan 09;375(9709):123-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adenine / analogs & derivatives. Adenine / therapeutic use. Adolescent. Adult. Africa / epidemiology. Aged. Anemia / epidemiology. CD4 Lymphocyte Count. Creatinine / analysis. Dideoxynucleosides / therapeutic use. Disease Progression. Female. Glomerular Filtration Rate. HIV-1 / genetics. HIV-Associated Lipodystrophy Syndrome / epidemiology. Hemoglobins / analysis. Humans. Lamivudine / therapeutic use. Male. Middle Aged. Neutropenia / epidemiology. Neutrophils / metabolism. Nevirapine / therapeutic use. Organophosphonates / therapeutic use. RNA, Viral / metabolism. Tenofovir. Urea / analysis. Viral Load. Zidovudine / therapeutic use

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20004464.001).
  • [ISSN] 1474-547X
  • [Journal-full-title] Lancet (London, England)
  • [ISO-abbreviation] Lancet
  • [Language] eng
  • [Databank-accession-numbers] ISRCTN/ ISRCTN13968779
  • [Grant] United Kingdom / Medical Research Council / / G0600344; United Kingdom / Medical Research Council / / MC/ U122886352; United Kingdom / Medical Research Council / / MC/ U950080931; United Kingdom / Medical Research Council / /
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents; 0 / Dideoxynucleosides; 0 / Hemoglobins; 0 / Organophosphonates; 0 / RNA, Viral; 2T8Q726O95 / Lamivudine; 4B9XT59T7S / Zidovudine; 8W8T17847W / Urea; 99DK7FVK1H / Nevirapine; 99YXE507IL / Tenofovir; AYI8EX34EU / Creatinine; JAC85A2161 / Adenine; WR2TIP26VS / abacavir
  • [Other-IDs] NLM/ PMC2805723
  • [Investigator] Gilks CF; Mugyenyi P; Hakim J; Reid A; Bray D; Darbyshire JH; Gibb DM; Babiker AG; Mugyenyi P; Grosskurth H; Katabira E; Kityo C; Munderi P; Ssali F; Hakim J; Reid A; Gibb DM; Gilks CF; Babiker AG; Walker AS
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50. Kasolo FC, Spinks J, Bima H, Bates M, Gompels UA: Diverse genotypes of Kaposi's sarcoma associated herpesvirus (KSHV) identified in infant blood infections in African childhood-KS and HIV/AIDS endemic region. J Med Virol; 2007 Oct;79(10):1555-61
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  • [Title] Diverse genotypes of Kaposi's sarcoma associated herpesvirus (KSHV) identified in infant blood infections in African childhood-KS and HIV/AIDS endemic region.
  • Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) has been associated with several neoplasias, including childhood endemic Kaposi's sarcoma (KS).
  • Early studies, at the advent of the HIV/AIDS epidemic, identified only the K1-A5 genotype in childhood KS biopsies as well as blood of a few HIV positive and negative febrile infants in Zambia, a highly endemic region.

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
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  • (PMID = 17705172.001).
  • [ISSN] 0146-6615
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] ENG
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / K1 protein, Human herpesvirus 8; 0 / Viral Proteins
  • [Other-IDs] NLM/ PMC2683451
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51. Guiguet M, Boué F, Cadranel J, Lang JM, Rosenthal E, Costagliola D, Clinical Epidemiology Group of the FHDH-ANRS CO4 cohort: Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study. Lancet Oncol; 2009 Dec;10(12):1152-9
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  • [Title] Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study.
  • BACKGROUND: The relative roles of immunodeficiency, HIV viral load, and combination antiretroviral therapy (cART) in the onset of individual cancers have rarely been examined.
  • We examined the effect of these factors on the risk of specific cancers in patients infected with HIV-1.
  • METHODS: We investigated the incidence of both AIDS-defining cancers (Kaposi's sarcoma, non-Hodgkin lymphoma, and cervical cancer) and non-AIDS-defining cancers (Hodgkin's lymphoma, lung cancer, liver cancer, and anal cancer) in 52 278 patients followed up in the French Hospital Database on HIV cohort during 1998-2006 (median follow-up 4.9 years, IQR 2.1-7.9; 255 353 person-years).
  • FINDINGS: Current CD4 cell count was the most predictive risk factor for all malignancies apart from anal cancer.
  • Compared with patients with CD4 count greater than 500 cells per microL, rate ratios (RR) ranged from 1.9 (95% CI 1.3-2.7) for CD4 counts 350-499 cells per microL to 25.2 (17.1-37.0) for counts less than 50 cells per microL for Kaposi's sarcoma (p<0.0001), from 1.3 (0.9-2.0) to 14.8 (9.7-22.6) for non-Hodgkin lymphoma (p<0.0001), from 1.2 (0.7-2.2) to 5.4 (2.4-12.1) for Hodgkin's lymphoma (p<0.0001), from 2.2 (1.3-3.6) to 8.5 (4.3-16.7) for lung cancer (p<0.0001), and from 2.0 (0.9-4.5) to 7.6 (2.7-20.8) for liver cancer (p<0.0001).
  • For cervical cancer, we noted a strong effect of current CD4 (RR 0.7 per log(2), 95% CI 0.6-0.8; p=0.0002).
  • The risk of Kaposi's sarcoma and non-Hodgkin lymphoma increased for current plasma HIV RNA greater than 100 000 copies per mL compared with patients with controlled viral load (RR 3.1, 95% CI 2.3-4.2, p<0.0001; and 2.9, 2.1-3.9, p<0.0001, respectively), whereas cART was independently associated with a decreased incidence (0.3, 0.2-0.4, p<0.0001; and 0.8, 0.6-1.0, p=0.07, respectively).
  • The RR of cervical cancer for those receiving cART was 0.5 (0.3-0.9; p=0.03).
  • The risk of anal cancer increased with the time during which the CD4 count was less than 200 cells per microL (1.3 per year, 1.2-1.5; p=0.0001), and viral load was greater than 100 000 copies per mL (1.2 per year, 1.1-1.4, p=0.005).
  • Cancer-specific screening programmes need to be assessed in patients with HIV.


52. Phipps W, Ssewankambo F, Nguyen H, Saracino M, Wald A, Corey L, Orem J, Kambugu A, Casper C: Gender differences in clinical presentation and outcomes of epidemic Kaposi sarcoma in Uganda. PLoS One; 2010 Nov 12;5(11):e13936
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  • To identify gender-related differences in KS presentation and outcomes, we evaluated the clinical manifestations and response in men and women with AIDS-associated KS in Uganda.
  • METHODS AND FINDINGS: HIV-infected adults with KS attending the Infectious Diseases Institute (IDI) and Uganda Cancer Institute (UCI) in Kampala, Uganda between 2004 and 2006 were included in a retrospective cohort.


53. Woolfrey AE, Malhotra U, Harrington RD, McNevin J, Manley TJ, Riddell SR, Coombs RW, Appelbaum FR, Corey L, Storb R: Generation of HIV-1-specific CD8+ cell responses following allogeneic hematopoietic cell transplantation. Blood; 2008 Oct 15;112(8):3484-7
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  • The HIV RNA remained undetectable and no HIV-associated infections were observed.

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  • (PMID = 18698002.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00112593
  • [Grant] United States / NIAID NIH HHS / AI / K08 AI 059173; United States / NIAID NIH HHS / AI / R21 AI064061; United States / NCI NIH HHS / CA / CA18029; United States / NCI NIH HHS / CA / P01 CA018029; United States / NCI NIH HHS / CA / P30 CA015704; United States / NCI NIH HHS / CA / CA78902; United States / NIAID NIH HHS / AI / K08 AI059173; United States / NIAID NIH HHS / AI / AI57005; United States / NIAID NIH HHS / AI / AI64061; United States / NCI NIH HHS / CA / CA15704; United States / NIAID NIH HHS / AI / P01 AI057005; United States / NCI NIH HHS / CA / P01 CA078902
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Epitopes; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine; HU9DX48N0T / Mycophenolic Acid
  • [Other-IDs] NLM/ PMC2569185
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54. Siegel K, Schrimshaw EW, Brown-Bradley CJ, Lekas HM: Sources of emotional distress associated with diarrhea among late middle-age and older HIV-infected adults. J Pain Symptom Manage; 2010 Sep;40(3):353-69
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  • [Title] Sources of emotional distress associated with diarrhea among late middle-age and older HIV-infected adults.

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  • [Copyright] 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.
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  • (PMID = 20579836.001).
  • [ISSN] 1873-6513
  • [Journal-full-title] Journal of pain and symptom management
  • [ISO-abbreviation] J Pain Symptom Manage
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / AG016571-01A2; United States / NIA NIH HHS / AG / R01 AG016571; United States / NIA NIH HHS / AG / R01 AG016571-01A2; United States / NIA NIH HHS / AG / R01-AG13379
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS207737; NLM/ PMC2933942
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55. Achachi A, Florins A, Gillet N, Debacq C, Urbain P, Foutsop GM, Vandermeers F, Jasik A, Reichert M, Kerkhofs P, Lagneaux L, Burny A, Kettmann R, Willems L: Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo. Proc Natl Acad Sci U S A; 2005 Jul 19;102(29):10309-14
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  • Conceptually, induction of viral or cellular gene expression could thus also be used as a therapeutic strategy against retroviral-associated leukemia.
  • The concept of a therapy that targets the expression of viral and cellular genes might be a promising treatment of adult T cell leukemia or tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy, diseases for which no satisfactory treatment exists so far.

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  • (PMID = 16006517.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Histone Deacetylase Inhibitors; 614OI1Z5WI / Valproic Acid; EC 1.13.12.- / Luciferases
  • [Other-IDs] NLM/ PMC1177395
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56. Feldman DN, Feldman JG, Greenblatt R, Anastos K, Pearce L, Cohen M, Gange S, Leanza S, Burk R: CYP1A1 genotype modifies the impact of smoking on effectiveness of HAART among women. AIDS Educ Prev; 2009 Jun;21(3 Suppl):81-93
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  • We have recently shown that cigarette smoking is associated with lesser responses to potent antiretroviral therapies.
  • Our findings showed that GSTM1 and GSST1 deletions were not associated with HAART effectiveness.
  • By contrast, homozygosity for the CYP1A1-m1 polymorphism, was associated with impaired viral response to treatment among smokers (relative hazard (RH) = 0.54; 95% confidence interval = 0.31-0.94) after adjustment for pretreament viral load, CD4 count, age, hepatitis C infection, prior HAART therapy and race, although it had no effect among nonsmokers.

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  • (PMID = 19537956.001).
  • [ISSN] 1943-2755
  • [Journal-full-title] AIDS education and prevention : official publication of the International Society for AIDS Education
  • [ISO-abbreviation] AIDS Educ Prev
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / M01 RR000079; United States / NIAID NIH HHS / AI / U01-AI-42590; United States / NIAID NIH HHS / AI / U01 AI031834; United States / NIAID NIH HHS / AI / U01 AI031834-17; United States / NIAID NIH HHS / AI / U01 AI035004; United States / NICHD NIH HHS / HD / U01-HD-32632; United States / NIAID NIH HHS / AI / U01 AI034989; United States / NCRR NIH HHS / RR / M01-RR-00083; United States / NCRR NIH HHS / RR / M01 RR000071; United States / NIAID NIH HHS / AI / U01-AI-34994; United States / NIAID NIH HHS / AI / AI042590-12; United States / NIAID NIH HHS / AI / U01-AI-35004; United States / NIAID NIH HHS / AI / U01-AI-31834; United States / NCRR NIH HHS / RR / M01-RR-00079; United States / NIAID NIH HHS / AI / U01 AI034994; United States / NIAID NIH HHS / AI / AI031834-17; United States / NIAID NIH HHS / AI / U01-AI-34993; United States / NIAID NIH HHS / AI / U01 AI042590-12; United States / NCRR NIH HHS / RR / M01-RR-00071; United States / NIAID NIH HHS / AI / U01 AI034993; United States / NCRR NIH HHS / RR / M01 RR000083; United States / NIAID NIH HHS / AI / U01-AI-34989; United States / NICHD NIH HHS / HD / U01 HD032632; United States / NIAID NIH HHS / AI / U01 AI042590
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / DNA Adducts; EC 1.14.14.1 / Cytochrome P-450 CYP1A1; EC 2.5.1.18 / Glutathione Transferase
  • [Other-IDs] NLM/ NIHMS138239; NLM/ PMC2754267
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57. Dayaram T, Marriott SJ: Effect of transforming viruses on molecular mechanisms associated with cancer. J Cell Physiol; 2008 Aug;216(2):309-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of transforming viruses on molecular mechanisms associated with cancer.
  • Interestingly, since transforming viruses affect some of the same pathways that are dysregulated in human cancers, their study enhances our understanding of the multistep process of tumorigenesis.
  • While the transforming properties of these viruses are probably unintended consequences of replication strategies, they provide excellent systems in which to study cancer development.

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18366075.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA055684; United States / NCI NIH HHS / CA / CA-77371; United States / NCI NIH HHS / CA / R01 CA077371; United States / NCI NIH HHS / CA / CA-55684; United States / NCI NIH HHS / CA / P30 CA125123
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / Cell Cycle Proteins; 0 / Oncogene Proteins; 0 / Receptors, Tumor Necrosis Factor, Type I; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53; 0 / Viral Proteins
  • [Number-of-references] 58
  • [Other-IDs] NLM/ NIHMS623319; NLM/ PMC4160108
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58. Mester B, Nieters A, Deeg E, Elsner G, Becker N, Seidler A: Occupation and malignant lymphoma: a population based case control study in Germany. Occup Environ Med; 2006 Jan;63(1):17-26
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  • [Title] Occupation and malignant lymphoma: a population based case control study in Germany.
  • AIMS: To identify occupations suspected to be associated with malignant lymphoma and to generate new hypotheses about occupational risks in a multicentre, population based case control study.
  • METHODS: Male and female patients with malignant lymphoma (n = 710) aged 18-80 years of age were prospectively recruited in six study regions in Germany.
  • RESULTS: The following economic/industrial sectors were positively associated with lymphoma: food products, beverages, tobacco; paper products, publishing and printing; and metals.
  • Chemicals; real estate, renting, and business activities were negatively associated with lymphoma diagnosis.
  • Shoemaking and leather goods making was negatively associated with the lymphoma diagnosis (although based on small numbers).
  • In the occupational group analysis of lymphoma subentities, Hodgkin's lymphoma was significantly associated only with rubber and plastic products making; diffuse large B cell lymphoma risk was considerably increased among metal processors; follicular lymphoma showed highly significant risk increases for several occupational groups (medical, dental, and veterinary workers; sales workers; machinery fitters; and electrical fitters); and multiple myeloma showed a particularly pronounced risk increase for farmers as well as for agriculture and animal husbandry workers.
  • Occupational risk factors for follicular lymphomas might differ from the overall risk factors for malignant lymphoma.

  • MedlinePlus Health Information. consumer health - Lymphoma.
  • MedlinePlus Health Information. consumer health - Occupational Health.
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