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1. Wang J, Wang R, Han D, Yang W: [Esthesioneuroblastoma in children]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 Jun;20(11):491-3
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  • [Title] [Esthesioneuroblastoma in children].
  • OBJECTIVE: To summarize the clinical characterization of esthesioneuroblastoma in children and adolescence.
  • METHOD: The esthesioneuroblastoma in children treated in our hospital from 1993 to 2004 were retrospectively evaluated, and thorough literature review of patients with esthesioneuroblastoma was performed by searching for the key word "esthesioneuroblastoma" in CHKD and in Pub Med between 1994-2004, also looking for its reference.
  • The main symptoms were nasal occlusion, proptosis, epistaxis, headache and the main location of disease were the intranasal, ethmoid sinus, orbital, anterior cranial fossa.
  • CONCLUSION: Esthesioneuroblastoma in children is very rare and combined surgery and radiotherapy should be selected.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Nose Neoplasms

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  • (PMID = 16929827.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] China
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2. Rastogi M, Bhatt M, Chufal K, Srivastava M, Pant M, Srivastava K, Mehrotra S: Esthesioneuroblastoma treated with non-craniofacial resection surgery followed by combined chemotherapy and radiotherapy: An alternative approach in limited resources. Jpn J Clin Oncol; 2006 Oct;36(10):613-9
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  • [Title] Esthesioneuroblastoma treated with non-craniofacial resection surgery followed by combined chemotherapy and radiotherapy: An alternative approach in limited resources.
  • BACKGROUND: Esthesioneuroblastoma (ENB) is a rare and aggressive malignant tumor arising from olfactory epithelium.
  • The purpose of the study is to analyze the outcome of this disease when managed by non-craniofacial resection (NCFR) surgery in limited resources.
  • Disease-free survival and overall survival at 3 years was 72.9 and 71.4%, respectively, and median disease-free survival time was 43 months, while mean overall survival time was 40.7 months as median overall survival time was not reached.
  • Most of the patients in our series were of stage C disease (75%) and still our response rate and survival were encouraging despite the fact that surgery was not optimal.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Esthesioneuroblastoma, Olfactory / drug therapy. Esthesioneuroblastoma, Olfactory / radiotherapy. Nasal Cavity. Nose Neoplasms / drug therapy. Nose Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Combined Modality Therapy. Cyclophosphamide / administration & dosage. Disease-Free Survival. Dose Fractionation. Doxorubicin / administration & dosage. Drug Administration Schedule. Female. Humans. Male. Middle Aged. Registries. Survival Rate. Vincristine / administration & dosage

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  • (PMID = 16926225.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; CAV protocol
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3. von Bülow MN, Caselitz J, Rieckhoff K, Grundmann T, Schaudig U: [Esthesioneuroblastoma: lidswelling as a primary symptom of a nasal tumor]. Klin Monbl Augenheilkd; 2008 Oct;225(10):890-1
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  • [Title] [Esthesioneuroblastoma: lidswelling as a primary symptom of a nasal tumor].
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / complications. Esthesioneuroblastoma, Olfactory / diagnosis. Eyelid Diseases / diagnosis. Eyelid Diseases / etiology. Nasal Cavity / pathology. Nose Neoplasms / complications. Nose Neoplasms / diagnosis

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  • (PMID = 18951311.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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4. Abe T, Goda M, Kamida T, Fujiki M, Kobayashi H, Nakano T, Mori T, Watanabe T, Suzuki M: Overlapping free bone graft with galea-pericranium in reconstruction of the anterior skull base to prevent CSF leak and sequestrum formation. Acta Neurochir (Wien); 2007 Aug;149(8):771-5; discussion 775
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  • Background. Reconstruction of the skull base after resection of a tumour is important to prevent postoperative complications such as infectionsand cerebrospinal fluid (CSF) leakage.
  • Methods. We describe a technique used after removal of an olfactory neuroblastoma with infiltration of the skull base.
  • The reconstructed dura was covered with a galeal patch, a replicated galeal-pericranial flap, a graft from the inner table of skull, and a vascularised galeal-pericranial flap placed on the skull base defect.
  • [MeSH-major] Bone Transplantation / methods. Cerebrospinal Fluid Otorrhea / prevention & control. Cerebrospinal Fluid Rhinorrhea / prevention & control. Cranial Fossa, Anterior / surgery. Paranasal Sinus Neoplasms / surgery. Postoperative Complications / prevention & control. Skull Base Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / surgery. Aged. Fibrin Tissue Adhesive / administration & dosage. Ganglioneuroblastoma / diagnosis. Ganglioneuroblastoma / surgery. Humans. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Infant. Infant, Newborn. Magnetic Resonance Imaging. Neoplasms, Multiple Primary / diagnosis. Neoplasms, Multiple Primary / surgery. Tomography, X-Ray Computed

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  • [CommentIn] Acta Neurochir (Wien). 2009 Oct;151(10):1337-8 [19444373.001]
  • (PMID = 17565426.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive
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5. Rostomily RC, Elias M, Deng M, Elias P, Born DE, Muballe D, Silbergeld DL, Futran N, Weymuller EA, Mankoff DA, Eary J: Clinical utility of somatostatin receptor scintigraphic imaging (octreoscan) in esthesioneuroblastoma: a case study and survey of somatostatin receptor subtype expression. Head Neck; 2006 Apr;28(4):305-12
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  • [Title] Clinical utility of somatostatin receptor scintigraphic imaging (octreoscan) in esthesioneuroblastoma: a case study and survey of somatostatin receptor subtype expression.
  • Discriminating between postoperative changes and residual or recurrent tumor after extensive skull base surgery is often difficult, but in a case of recurrent esthesioneuroblastoma (ENB) we found the use of Octreoscan imaging clinically useful.
  • METHODS: The case history and correlations between MRI and 111In-pentetreotide SRS of a patient with recurrent ENB were reviewed.
  • CONCLUSION: The expression pattern of SSTR2 and the specificity of the Octreoscan for regions of active tumor growth support further investigation of the utility of Octreoscan imaging in the diagnosis and surveillance of ENB.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / metabolism. Esthesioneuroblastoma, Olfactory / radionuclide imaging. Nose Neoplasms / metabolism. Nose Neoplasms / radionuclide imaging. Receptors, Somatostatin / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Humans. Indium Radioisotopes / pharmacokinetics. Male. Middle Aged. Nasal Cavity / radionuclide imaging. Octreotide / pharmacokinetics. Radiopharmaceuticals / pharmacokinetics. Somatostatin / analogs & derivatives. Somatostatin / pharmacokinetics. Tomography, Emission-Computed, Single-Photon

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  • [Copyright] Copyright 2005 Wiley Periodicals, Inc.
  • (PMID = 16470879.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / 2-T32-NS-007144-24
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Indium Radioisotopes; 0 / Radiopharmaceuticals; 0 / Receptors, Somatostatin; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide; RWM8CCW8GP / Octreotide
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6. Suzuki M, Sakurai H, Seno S, Hoshi J, Ogawa T, Arikata M, Tojima I, Kitanishi T, Tanaka H, Shimizu T: [Endoscopic resection of benign and malignant tumors in the nasal cavity and paranasal sinus]. Nihon Jibiinkoka Gakkai Kaiho; 2005 Jul;108(7):724-33
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  • [Title] [Endoscopic resection of benign and malignant tumors in the nasal cavity and paranasal sinus].
  • Endoscopic resection of nasal and paranasal sinus tumors is more aesthetic and less invasive than conventional resection, such as Luc's operation and lateral rhinotomy.
  • Subjects were patients with benign lesions in the nasal cavity, medial wall of the maxillary sinus, ethmoid sinus, and/or sphenoid sinus without concurrent malignant lesions.
  • Although patients selection for malignant tumor excision was based on (1) possible en bloc resection, (2) low-grade malignant tumors, and (3) tumors in the nasal cavity and adjoining paranasal sinus, the final decision was made individual.
  • Subjects were 23 patients with benign tumor (10 inverted papilloma, 9 hemangioma, 2 juvenile angiofibroma, and 2 other tumors) and 4 with malignant tumor (olfactory neuroblastoma, acinic cell carcinoma, squamous cell carcinoma, and chondroid chordoma) in the nasal and paranasal sinus.
  • The endoscopic excision of benign lesions in the nasal and paranasal sinus is thus as effective as conventional radical surgery.
  • Endoscopic removal of malignant lesions remains controversial because of the small number of patients and short postoperative observation.
  • [MeSH-major] Endoscopy. Nasal Cavity. Nose Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 16107047.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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7. Reichel O, Ihrler S, Born F, Andratschke M, Rasp G, Hagedorn H: [Sinonasal undifferentiated carcinoma. A rare and aggressive neoplasm of the nasal cavity and paranasal sinuses]. HNO; 2006 May;54(5):394-6, 398-9
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  • [Title] [Sinonasal undifferentiated carcinoma. A rare and aggressive neoplasm of the nasal cavity and paranasal sinuses].
  • [Transliterated title] Das sinunasale undifferenzierte Karzinom. Ein seltener und aggressiver Tumor der Nasenhaupt- und Nasennebenhöhlen.
  • Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor of the nasal cavity and paranasal sinuses first described in 1986.
  • Olfactory neuroblastoma and SNUC may appear quite similar on histological examination.
  • Due to the fact that olfactory neuroblastoma has a much better prognosis, a distinction with SNUC has to be drawn.
  • We report a case of SNUC and describe the role of immunohistochemistry in making an accurate histological diagnosis.
  • [MeSH-major] Carcinoma / diagnosis. Nasal Cavity. Nose Neoplasms / diagnosis. Paranasal Sinus Neoplasms / diagnosis. Sphenoid Sinus
  • [MeSH-minor] Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Radiotherapy, Adjuvant. Skull Base / pathology

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  • (PMID = 16034634.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Sinha SK, Abrams JH, Houle TT, Weller RS: Ultrasound-guided obturator nerve block: an interfascial injection approach without nerve stimulation. Reg Anesth Pain Med; 2009 May-Jun;34(3):261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND AND OBJECTIVES: For knee surgery, obturator nerve block (ONB) has been shown to enhance postoperative analgesia provided by femoral block.
  • This preliminary observational study evaluated the success of an ultrasound-guided ONB without the additional use of nerve stimulation.
  • METHODS: Thirty patients scheduled for knee surgery under general anesthesia with nerve block for postoperative analgesia had ONB performed using USG and injection of 10 mL 0.5% ropivacaine with epinephrine.


9. Ueno H, Kobayashi Y, Yamada K: Olfactory esthesioneuroblastoma treated with orthovoltage radiotherapy in a dog. Aust Vet J; 2007 Jul;85(7):271-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Olfactory esthesioneuroblastoma treated with orthovoltage radiotherapy in a dog.
  • On computed tomography examination, a mass was demonstrated in the nasal cavity.
  • Open biopsy of the mass was performed and a diagnosis of olfactory esthesioneuroblastoma was made on histological examination.
  • [MeSH-major] Dog Diseases / radiotherapy. Esthesioneuroblastoma, Olfactory / veterinary
  • [MeSH-minor] Animals. Dogs. Dose-Response Relationship, Radiation. Female. Neoplasm Recurrence, Local. Radiotherapy Dosage. X-Rays

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  • (PMID = 17615040.001).
  • [ISSN] 0005-0423
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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10. Kim JW, Kong IG, Lee CH, Kim DY, Rhee CS, Min YG, Kim CW, Chung JH: Expression of Bcl-2 in olfactory neuroblastoma and its association with chemotherapy and survival. Otolaryngol Head Neck Surg; 2008 Nov;139(5):708-12
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  • [Title] Expression of Bcl-2 in olfactory neuroblastoma and its association with chemotherapy and survival.
  • OBJECTIVE: This study aimed to identify the prognostic value of tumor markers in olfactory neuroblastoma (ONB).
  • STUDY DESIGN AND SETTING: Seventeen patients with ONB (23 tumor specimens) were included.
  • All of the ONB specimens were negative for N-myc.
  • CONCLUSION: Bcl-2 expression was commonly found in ONB and the immunoreactivity for bcl-2 might predict response to neoadjuvant chemotherapy.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / metabolism. Esthesioneuroblastoma, Olfactory / therapy. Nasal Cavity. Nose Neoplasms / metabolism. Nose Neoplasms / therapy. Proto-Oncogene Proteins c-bcl-2 / metabolism

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  • (PMID = 18984268.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2
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11. Umeda Y, Matsumoto M, Aiso S, Nishizawa T, Nagano K, Arito H, Fukushima S: Inhalation carcinogenicity and toxicity of 1,2-dichloropropane in rats. Inhal Toxicol; 2010 Nov;22(13):1116-26
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  • Thirteen-week exposure to DCP induced hyperplasia in the respiratory epithelium and atrophy of the olfactory epithelium at 125 ppm and above.
  • Two-year exposure to DCP significantly increased incidences of papilloma in the nasal cavity of male and female rats exposed to 500 ppm DCP.
  • In addition, three cases of esthesioneuroepithelioma were observed in the DCP-exposed male rats.
  • Total nasal tumors increased in a concentration-dependent manner.
  • Atrophy of the olfactory epithelium, inflammation of the respiratory epithelium, and squamous cell metaplasia were also seen in the 2-year study.
  • These results demonstrate that DCP is a nasal carcinogen in rats.
  • [MeSH-major] Carcinogens / toxicity. Nasal Cavity / pathology. Nose Neoplasms / chemically induced. Propane / analogs & derivatives

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  • (PMID = 21070183.001).
  • [ISSN] 1091-7691
  • [Journal-full-title] Inhalation toxicology
  • [ISO-abbreviation] Inhal Toxicol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; RRZ023OFWL / propylene dichloride; T75W9911L6 / Propane
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12. Nicolai P, Battaglia P, Bignami M, Bolzoni Villaret A, Delù G, Khrais T, Lombardi D, Castelnuovo P: Endoscopic surgery for malignant tumors of the sinonasal tract and adjacent skull base: a 10-year experience. Am J Rhinol; 2008 May-Jun;22(3):308-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic surgery for malignant tumors of the sinonasal tract and adjacent skull base: a 10-year experience.
  • The most frequent histotypes encountered were adenocarcinoma (37%), squamous cell carcinoma (13.6%), olfactory neuroblastoma (12%), mucosal melanoma (9.2%), and adenoid cystic carcinoma (7.1%).
  • The 5-year disease-specific survival was 91.4 +/- 3.9% and 58.8 +/- 8.6% (p = 0.0004) for the EEA and CEA group, respectively.
  • CONCLUSION: To the best of our knowledge, this is the largest series reported to date of malignant tumors of the sinonasal tract and adjacent skull base treated with pure endoscopic or cranioendoscopic techniques.
  • A 5-year disease-specific survival of 91.4% and 58.8% for the EEA and the CEA groups, respectively, seem to indicate that endoscopic surgery, when properly planned and in expert hands, may be a valid alternative to standard surgical approaches for the management of malignancies of the sinonasal tract.
  • [MeSH-major] Endoscopy / methods. Otorhinolaryngologic Surgical Procedures / methods. Paranasal Sinus Neoplasms / surgery. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Female. Follow-Up Studies. Humans. Incidence. Italy / epidemiology. Length of Stay. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Nose. Retrospective Studies. Skull. Survival Rate / trends. Time Factors. Treatment Outcome

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  • (PMID = 18588765.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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13. Saint-Blancard P, Kossowski M: [Sinonasal mucosal malignant melanoma]. Presse Med; 2006 Nov;35(11 Pt 1):1664-7
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  • [Title] [Sinonasal mucosal malignant melanoma].
  • [Transliterated title] Mélanomes des muqueuses nasosinusiennes.
  • INTRODUCTION: Mucosal melanomas are rare tumors, and primary sinonasal malignant melanomas uncommon tumors that are frequently misclassified.
  • Differential diagnosis should rule out other sinonasal malignancies, including carcinoma, lymphoma, sarcoma, and olfactory neuroblastoma.
  • One involved a 68-year-old man being followed for chronic sinusitis, despite antibiotics; he presented a tumor of the right nasal cavity.
  • The second case was that of a 77-year-old woman, referred for painful gingival swelling shown to involve osteolytic growth in the left maxillary sinus.
  • In both cases, pathologic examination of the biopsy samples concluded that these were sinonasal malignant melanomas.
  • DISCUSSION: Histologically, the diagnosis is very difficult because of the polymorphic features of this tumor, and immunohistochemical studies are very important.
  • The relative inaccessibility of the mucosa to self-examination often delays diagnosis and leads to late detection and poor prognosis.
  • [MeSH-major] Melanoma / pathology. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 17086122.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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14. Piro NA, Cummins CC: An unusual P-P double bond formed via phospha-Wittig transformation of a terminal PO complex. J Am Chem Soc; 2009 Jul 1;131(25):8764-5
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  • [Title] An unusual P-P double bond formed via phospha-Wittig transformation of a terminal PO complex.
  • The terminal phosphorus monoxide complex (OP)Mo(N[(t)Bu]Ar)(3), 1 (Ar = 3,5-Me(2)C(6)H(3)), undergoes an O-for-PSiR(3) metathesis reaction with the niobium phosphinidene complex (i)Pr(3)SiPNb(N[CH(2)(t)Bu]Ar)(3), 2, to generate the oxoniobium complex ONb(N[CH(2)(t)Bu]Ar)(3), 3, and the diphosphenido complex (i)Pr(3)SiPPMo(N[(t)Bu]Ar)(3), 4.

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  • (PMID = 19505095.001).
  • [ISSN] 1520-5126
  • [Journal-full-title] Journal of the American Chemical Society
  • [ISO-abbreviation] J. Am. Chem. Soc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Schwedt TJ, Dodick DW, Trentman TL, Zimmerman RS: Response to occipital nerve block is not useful in predicting efficacy of occipital nerve stimulation. Cephalalgia; 2007 Mar;27(3):271-4
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  • The objective of this study was to determine if response to occipital nerve block (ONB) predicts response to ONS in patients with chronic, medically intractable headaches.
  • Data were collected regarding analgesic response to ONB and to ONS.
  • Thirteen patients had ONB prior to stimulator implantation.
  • Ten of 13 who had ONB had significant relief of head pain lasting at least 24 h, and three were ONB non-responders.
  • Of the three ONB non-responders, two were ONS responders.
  • Of the two patients who did not have ONB prior to ONS, one was an ONS responder and one was an ONS non-responder.
  • In conclusion, analgesic response to ONB may not be predictive of the therapeutic effect from ONS in patients with medically refractory chronic headaches.
  • [MeSH-major] Cranial Nerves. Electric Stimulation Therapy / methods. Headache / diagnosis. Headache / therapy. Nerve Block / methods. Outcome Assessment (Health Care) / methods

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  • (PMID = 17381559.001).
  • [ISSN] 0333-1024
  • [Journal-full-title] Cephalalgia : an international journal of headache
  • [ISO-abbreviation] Cephalalgia
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
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16. Nguyen BD, Roarke MC, Nelson KD, Chong BW: F-18 FDG PET/CT staging and posttherapeutic assessment of esthesioneuroblastoma. Clin Nucl Med; 2006 Mar;31(3):172-4
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  • [Title] F-18 FDG PET/CT staging and posttherapeutic assessment of esthesioneuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / diagnosis. Esthesioneuroblastoma, Olfactory / secondary. Fluorodeoxyglucose F18. Nasal Cavity / radiography. Nasal Cavity / radionuclide imaging. Nose Neoplasms / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Positron-Emission Tomography / methods. Radiopharmaceuticals

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  • (PMID = 16495744.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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17. Pino Rivero V, Trinidad Ruíz G, González Palomino A, Pardo Romero G, Pantoja Hernández CG, Marcos García M, Montero García C, Blasco Huelva A: [Olfactory neuroblastoma in an old patient. Report of a case]. An Otorrinolaringol Ibero Am; 2005;32(5):429-35
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  • [Title] [Olfactory neuroblastoma in an old patient. Report of a case].
  • [Transliterated title] Neuroblastoma olfatorio en paciente de edad avanzada. Presentación de un caso.
  • Olfactory neuroblastoma or esthesioneuroblastoma is a rare embrionary tumor, much more in old patients, which uses to present as a pollipoid mass with nasal obstruction, epistaxis and anosmia of long evolution.
  • We report the case of a 82-year-old male with such symptoms diagnosed by biopsy as neuroblastoma class III according the histologic Hyams grading.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / radiography. Nasal Cavity / radiography. Nose Neoplasms / radiography

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  • (PMID = 16318085.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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18. Li G, Zhou J, Xiao X, Wang J: [Clinical analysis of 19 cases of esthesioneuroblastoma under classic surgical approaches and surgical approaches with the assistant of nose endoscope]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Jun;22(11):498-9, 503
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  • [Title] [Clinical analysis of 19 cases of esthesioneuroblastoma under classic surgical approaches and surgical approaches with the assistant of nose endoscope].
  • OBJECTIVE: To summarize the curative effect and esthesioneuroblastoma (ENB) by classic surgical approaches and surgical approaches with the assistant of nose endoscope.
  • After 1995, 9 cases (stageA, 2 case; stageB, 5 cases; stageC, 2 cases) received surgical resection with nasale endoscope.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / surgery. Nose Neoplasms / surgery

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  • (PMID = 18727518.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Preusser M, Hutterer M, Sohm M, Koperek O, Elandt K, Dieckmann K, Prayer D, Marosi C: Disease stabilization of progressive olfactory neuroblastoma (esthesioneuroblastoma) under treatment with sunitinib mesylate. J Neurooncol; 2010 Apr;97(2):305-8
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  • [Title] Disease stabilization of progressive olfactory neuroblastoma (esthesioneuroblastoma) under treatment with sunitinib mesylate.
  • Olfactory neuroblastoma (esthesioneuroblastoma) is a rare neoplasm of the olfactory epithelium in the upper nasal cavity.
  • Here, we report the case of a 69-year-old man who presented with massive progression of a metastatic esthesioneuroblastoma after endonasal resection, functional neck dissection, and radiotherapy of local and distant tumor relapses.
  • Using this drug, significant improvement of clinical symptoms, disease stabilization, and recovery from Karnofsky index of 40% to 70% could be achieved in the absence of significant adverse drug effects.
  • The patient died 15 months after initiation of sunitinib therapy due to complications of a traumatic femoral neck fracture without evidence of tumor progression.
  • Sunitinib should be considered for palliative therapy of advanced esthesioneuroblastoma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Esthesioneuroblastoma, Olfactory / drug therapy. Indoles / therapeutic use. Nasal Cavity / pathology. Neoplasm Recurrence, Local / drug therapy. Nose Neoplasms / drug therapy. Pyrroles / therapeutic use


20. Döpke C, Gröne A, von Borstel M, von Oppen T, Boéve MH, Baumgärtner W: Metastatic esthesioneuroblastoma in a horse. J Comp Pathol; 2005 Feb-Apr;132(2-3):218-22
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  • [Title] Metastatic esthesioneuroblastoma in a horse.
  • At post-mortem examination a neoplasm was found involving the left ethmoid bone, left maxillary sinus, left orbit, left superior turbinate, and the left eye.
  • Electronmicroscopically, the cells showed neurosecretory granules with an electron-dense centre and a light halo, and microfilaments.
  • On the basis of macroscopical, light microscopical and ultrastructural findings a diagnosis of a metastatic esthesioneuroblastoma was made.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / veterinary. Horse Diseases / pathology. Nasal Cavity / pathology. Nose Neoplasms / veterinary

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  • (PMID = 15737348.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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21. Holland H, Koschny R, Krupp W, Meixensberger J, Bauer M, Kirsten H, Ahnert P: Comprehensive cytogenetic characterization of an esthesioneuroblastoma. Cancer Genet Cytogenet; 2007 Mar;173(2):89-96
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  • [Title] Comprehensive cytogenetic characterization of an esthesioneuroblastoma.
  • Esthesioneuroblastoma is a malignant neuroectodermal tumor originating from olfactory epithelial cells in the nasal vault.
  • Therefore, we performed comprehensive cytogenetic analyses of an esthesioneuroblastoma, Hyam's grade III-IV, using trypsin-Giemsa staining (GTG banding), multicolor fluorescence in situ hybridization (M-FISH), and locus-specific FISH complemented by molecular karyotyping using high-density single nucleotide polymorphism arrays.
  • Interestingly, we found two novel, so far not described deletions, del(2)(q37) and del(21)(q22).
  • Applying SNP array karyotyping, we confirmed the chromosomal aberrations del(2)(q37.3), del(3)(q27.2), del(10)(q26.11), chromosomal imbalance on 17q, del(21)(q22), and revealed a number of so far unknown aberrations (gain of 2q14.3, 13q33.3, and 13q34).
  • While the cytogenetically revealed low frequency mosaic del(6)(q22q24) was not visible using SNP array karyotyping, some of the smaller imbalances (SNP array data) could not have been detected by classic cytogenetic analysis.
  • [MeSH-major] Cytogenetic Analysis. Esthesioneuroblastoma, Olfactory / genetics. Nasal Cavity / metabolism. Nose Neoplasms / genetics

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  • (PMID = 17321323.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Araújo Rde P, Gomes EF, Menezes DB, Ferreira LM, Rios AS: Rare nasosinusal tumors: case series and literature review. Braz J Otorhinolaryngol; 2008 Mar-Apr;74(2):307-14
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  • Tumors of the nasal cavity and paranasal sinuses are unusual pathologies found in clinical practice.
  • The aim of this study is to describe a series of rare nasosinusal tumors, including esthesioneuroblastomas, central giant cell granulomas, extramedullary plasmocytomas, nasosinusal hemangiopericytomas, neurofibromas and cemento-ossifying fibromas, diagnosed at the Fortaleza General Hospital.
  • We, hereby, briefly review each of the aforementioned pathologies, stressing the need for a precise histological diagnosis for proper treatment in each case.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / diagnosis. Granuloma, Giant Cell / diagnosis. Hemangiopericytoma / diagnosis. Nasal Cavity. Paranasal Sinus Neoplasms / diagnosis. Plasmacytoma / diagnosis
  • [MeSH-minor] Adolescent. Adult. Epistaxis / etiology. Female. Humans. Middle Aged. Nasal Obstruction / etiology. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 18568214.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 30
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23. McVey GP, Power DG, Aherne NJ, Gibbons D, Carney DN: Post irradiation olfactory neuroblastoma (esthesioneuroblastoma): a case report and up to date review. Acta Oncol; 2009;48(6):937-40
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  • [Title] Post irradiation olfactory neuroblastoma (esthesioneuroblastoma): a case report and up to date review.
  • [MeSH-major] Cobalt Radioisotopes / adverse effects. Esthesioneuroblastoma, Olfactory / etiology. Lymphoma, Mantle-Cell / radiotherapy. Nasal Cavity / radiation effects. Neoplasms, Radiation-Induced / etiology. Nose Neoplasms / etiology. Palatal Neoplasms / radiotherapy

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  • (PMID = 19235572.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cobalt Radioisotopes
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24. Nakao K, Watanabe K, Fujishiro Y, Ebihara Y, Asakage T, Goto A, Kawahara N: Olfactory neuroblastoma: long-term clinical outcome at a single institute between 1979 and 2003. Acta Otolaryngol Suppl; 2007 Dec;(559):113-7
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  • [Title] Olfactory neuroblastoma: long-term clinical outcome at a single institute between 1979 and 2003.
  • CONCLUSIONS: The progression of olfactory neuroblastoma showed a biphasic pattern.
  • A high local failure rate suggests that craniofacial resection followed by postoperative radiotherapy should still be the standard treatment for olfactory neuroblastoma.
  • OBJECTIVE: The aim of this study was to evaluate factors associated with survival and local control of olfactory neuroblastoma in the long run and to estimate treatment strategies.
  • PATIENTS AND METHODS: Twelve patients (seven men and five women) who had undergone initial curative treatment for olfactory neuroblastoma were retrospectively analyzed.
  • RESULTS: Cause-specific 10-year survival was 64.8%, while disease-free 10-year survival remained 28.6%.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / epidemiology. Esthesioneuroblastoma, Olfactory / therapy. Peripheral Nervous System Neoplasms / epidemiology. Peripheral Nervous System Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Incidence. Male. Middle Aged. Neoplasm Recurrence, Local. Neurosurgical Procedures

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  • (PMID = 18340581.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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25. Bragg TM, Scianna J, Kassam A, Emami B, Brown HG, Hacein-Bey L, Clark JI, Muzaffar K, Boulis N, Prabhu VC: Clinicopathological review: esthesioneuroblastoma. Neurosurgery; 2009 Apr;64(4):764-70; discussion 770
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  • [Title] Clinicopathological review: esthesioneuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Nasal Cavity / pathology. Nose Neoplasms

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  • (PMID = 19349835.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Conference; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 59
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26. Wei YX, Han DM: [Management of nasal skull-base neoplasms with endoscopic minimally invasive technique: a report of 36 cases]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Dec;43(12):915-8
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  • [Title] [Management of nasal skull-base neoplasms with endoscopic minimally invasive technique: a report of 36 cases].
  • OBJECTIVE: To discuss the indication, efficacy and safety of endoscopic minimally invasive surgery technique in the management of nasal skull-base neoplasms.
  • METHODS: Thirty-six patients with nasal skull base neoplasms were treated from January 2000 to Jun 2004 under nasal endoscopy, including 16 nasopharyngeal fibroangioma, 8 sinus osteofibroma, 8 pituitary adenoma, 4 olfactory neuroblastoma.
  • All olfactory neuroblastoma and 2 pituitary adenoma received radiotherapy after operation.
  • RESULTS: Total or most of nasopharyngeal fibroangioma, sinus osteofibroma, olfactory neuroblastoma and pituitary adenoma were excised.
  • CONCLUSIONS: When the indications are selected appropriately, nasal skull-base neoplasms, including benign and malignant, can be well treated with nasal endoscopic minimally invasive surgery.
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Female. Fibroma, Ossifying / surgery. Humans. Male. Middle Aged. Minimally Invasive Surgical Procedures. Nasopharyngeal Neoplasms / surgery. Neuroblastoma / surgery. Nose / surgery. Olfactory Nerve / pathology. Pituitary Neoplasms / surgery. Young Adult

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  • (PMID = 19141243.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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27. Huang Q, Wu H, Wang Z, Zhang Z, Jia H: [Diagnosis and treatment of lateral skull base tumors in pediatric]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;22(16):734-7
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  • [Title] [Diagnosis and treatment of lateral skull base tumors in pediatric].
  • OBJECTIVE: To explore the diagnosis and treatment of lateral skull base tumors in children.
  • One had schwannoma of the trigeminal nerve, one had malignant melanoma, one had fibroma in temporal bone, one had chordoma, two had rhabdomyosarcoma, two had esthesioneuroblastoma.
  • The other 7 cases of benign or malignant tumors underwent surgery in different approaches.
  • CONCLUSION: Tumors in lateral skull base in children were rare, of which malignant tumors were more common compared to benign lesions.
  • CT and MRI are helpful in evaluating extent of disease and preoperative planning.
  • Radiation therapy and chemotherapy could be used for malignant tumors preoperatively and postoperatively.
  • [MeSH-major] Skull Base Neoplasms / diagnosis. Skull Base Neoplasms / surgery

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  • (PMID = 18975775.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Li LY, Chen L, Wang RG, Han DY, Huang DL, Yang WY: [Investigation of surgical managements of olfactory neuroblastoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Feb;43(2):89-91
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  • [Title] [Investigation of surgical managements of olfactory neuroblastoma].
  • OBJECTIVE: To evaluate the safety and efficacy of transnasal endoscopic resection and craniofacial resection through an external approach for olfactory neuroblastoma (ONB).
  • METHODS: Thirty two patients with ONB treated between 1987 and 2006 were retrospectively reviewed.
  • CONCLUSIONS: Olfactory neuroblastoma can be safely and effectively excised and reconstructed endoscopically with comparable degrees of tissue removal as with external approaches.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / surgery. Nose Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. Endoscopy. Female. Humans. Male. Middle Aged. Nasal Cavity. Retrospective Studies. Young Adult

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  • (PMID = 18510210.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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29. Renuka IV, Rao BS, Sasank R: Sinonasal neuro endocrine carcinoma extending into orbit - a case report. Indian J Otolaryngol Head Neck Surg; 2008 Jun;60(2):156-8
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  • They should be distinguished from Olfactory Neuroblastomas.
  • Later she developed nasal stuffiness. C.T.
  • Scan revealed a space occupying lesion in the right nostril extending into ethmoid sinus and orbit.
  • Functional endoscopic sinus surgery was done with decompression of the orbit.
  • The biopsy material was obtained from ethmoid sinus and orbit.

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  • [Cites] Cancer. 1976 Mar;37(3):1571-6 [1260676.001]
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  • (PMID = 23120526.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450525
  • [Keywords] NOTNLM ; Olfactory Neuroblastoma / Paranasal Sinuses / Small Cell Carcinoma / Small cell Neuroendocrine carcinoma
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30. Turano S, Mastroianni C, Manfredi C, Biamonte R, Ceniti S, Liguori V, De Simone R, Conforti S, Filice A, Rovito A, Viscomi C, Patitucci G, Palazzo S: Advanced adult esthesioneuroblastoma successfully treated with cisplatin and etoposide alternated with doxorubicin, ifosfamide and vincristine. J Neurooncol; 2010 May;98(1):131-5
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  • [Title] Advanced adult esthesioneuroblastoma successfully treated with cisplatin and etoposide alternated with doxorubicin, ifosfamide and vincristine.
  • The esthesioneuroblastoma is a rare neuroendocrine tumor that derives from the olfactory cells.
  • The most common symptoms are nasal bleeding, nasal clogging and, in locally advanced cases, signs/symptoms of intracranic hypertension such as papilla edema, cefalea, and vomiting.
  • Here, the case is reported of a young man (38 years old) with a locally advanced esthesioneuroblastoma.
  • After surgery, MRI showed residual disease in the nasal cavities and in the medial wall of the orbits responsible for blindness and bilateral exophthalmos within a month: a very short time.
  • Octreoscan and whole body CT scan confirmed a locally advanced disease, in the absence of metastases.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Combined Modality Therapy / methods. Endocrine Gland Neoplasms / drug therapy. Neuroblastoma / drug therapy

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  • Hazardous Substances Data Bank. CIS-DIAMINEDICHLOROPLATINUM .
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Hazardous Substances Data Bank. ETOPOSIDE .
  • Hazardous Substances Data Bank. IFOSFAMIDE .
  • Hazardous Substances Data Bank. VINCRISTINE .
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  • (PMID = 19924514.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. Pan F, Yu XH, Mo XX, You JL, Wang C, Chen H, Jiang GC: [Raman active vibrations of aluminosilicates]. Guang Pu Xue Yu Guang Pu Fen Xi; 2006 Oct;26(10):1871-5
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  • The result shows a decrease tendency in Raman frequencies in the 800-1200 cm(-1) frequency region with increase in four-coordinated Al content, which is assigned to the Si--Onb symmetry stretching vibrations.
  • The Raman spectra in the 700-800 cm(-1) frequency region is attributed to Al-Onb symmetry stretching vibrations.

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  • (PMID = 17205741.001).
  • [ISSN] 1000-0593
  • [Journal-full-title] Guang pu xue yu guang pu fen xi = Guang pu
  • [ISO-abbreviation] Guang Pu Xue Yu Guang Pu Fen Xi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Yuen AP, Fan YW, Fung CF, Hung KN: Endoscopic-assisted cranionasal resection of olfactory neuroblastoma. Head Neck; 2005 Jun;27(6):488-93
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  • [Title] Endoscopic-assisted cranionasal resection of olfactory neuroblastoma.
  • BACKGROUND: Cranionasal resection was first described in 1997 for the surgical resection of olfactory neuroblastoma.
  • The authors have routinely practiced cranionasal resection since 1996 for resection of all anterior skull base tumors in which the resultant skull base bony defect is limited to the nasal and sinus roof.
  • The aim of this study was to review the results of cranionasal resection for olfactory neuroblastoma.
  • METHODS: The results of cranionasal resection for olfactory neuroblastoma in six patients from 1996 to 2003 were reviewed.
  • Postoperative radiotherapy was given only to the patient with Kadesh stage C disease.
  • Postoperative radiotherapy is not necessary after clear resection of Kadesh A and B tumors.
  • [MeSH-major] Endoscopy. Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity. Nose Neoplasms / surgery

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 15880390.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Arnold PM, Habib A, Newell K, Anderson KK: Esthesioneuroblastoma metastatic to the thoracic intradural and extradural space. Spine J; 2009 May;9(5):e1-5
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  • [Title] Esthesioneuroblastoma metastatic to the thoracic intradural and extradural space.
  • BACKGROUND CONTEXT: Ethesioneuroblastoma (ENB) is a rare tumor of the olfactory epithelium that has been shown to metastasize mostly to the cervical lymphatics, with only infrequent spread to other locations.
  • Computed tomography of the chest showed no pulmonary metastasis and a high-attenuation spinal canal mass at T8 was noted on magnetic resonance imaging.
  • A laminectomy at T7-T8 was performed for resection of a large epidural mass.
  • A tumor was seen penetrating through the dura, and a midline durotomy was performed for resection of a large intradural mass.
  • [MeSH-major] Epidural Space / pathology. Esthesioneuroblastoma, Olfactory / secondary. Nasal Cavity / pathology. Nose Neoplasms / pathology. Spinal Cord Neoplasms / secondary
  • [MeSH-minor] Dura Mater / pathology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Thoracic Vertebrae

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  • (PMID = 18805062.001).
  • [ISSN] 1878-1632
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Das S, Kirsch CF: Imaging of lumps and bumps in the nose: a review of sinonasal tumours. Cancer Imaging; 2005;5:167-77
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  • Sinonasal disease is one of the most common clinical head and neck pathologies.
  • Although sinus tumours are rare, they portend a poor prognosis, often due to advanced disease at diagnosis.
  • Like most neoplasms, early detection improves prognosis, therefore clinicians and radiologists should be aware of features separating tumours from inflammatory sinus disease.
  • Benign neoplasms reviewed include osteoma, inverting papilloma, and juvenile nasal angiofibroma.
  • Malignant neoplasms reviewed include squamous cell carcinoma, the minor salivary gland tumour, adenoid cystic carcinoma, adenocarcinoma, melanoma, lymphoma, and olfactory neuroblastoma (esthesioneuroblastoma).
  • [MeSH-major] Paranasal Sinus Neoplasms / diagnosis

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  • [Copyright] International Cancer Imaging Society.
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  • (PMID = 16361146.001).
  • [ISSN] 1470-7330
  • [Journal-full-title] Cancer imaging : the official publication of the International Cancer Imaging Society
  • [ISO-abbreviation] Cancer Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 73
  • [Other-IDs] NLM/ PMC1665243
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35. Guled M, Myllykangas S, Frierson HF Jr, Mills SE, Knuutila S, Stelow EB: Array comparative genomic hybridization analysis of olfactory neuroblastoma. Mod Pathol; 2008 Jun;21(6):770-8
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  • [Title] Array comparative genomic hybridization analysis of olfactory neuroblastoma.
  • Olfactory neuroblastoma is an unusual neuroectodermal malignancy, which is thought to arise at the olfactory membrane of the sinonasal tract.
  • The aim of the current study is to identify specific DNA copy number changes in olfactory neuroblastoma.
  • Our results show that gene copy number profiles of olfactory neuroblastoma samples are complex.
  • Gains were more frequent than losses, and high-stage tumors showed more alterations than low-stage olfactory neuroblastoma.
  • In addition, our results indicate that gains in 20q and 13q may be important in the progression of this cancer, and that these regions possibly harbor genes with functional relevance in olfactory neuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / genetics. Nasal Cavity / pathology. Nose Neoplasms / genetics. Oligonucleotide Array Sequence Analysis

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  • (PMID = 18408657.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Cheng C, Long Xb: [Diagnosis and treatment of esthesioneuroblastoma in the nasal cavity and sinuses]. Nan Fang Yi Ke Da Xue Xue Bao; 2010 Oct;30(10):2402-3, 2405
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  • [Title] [Diagnosis and treatment of esthesioneuroblastoma in the nasal cavity and sinuses].
  • OBJECTIVE: To discuss the clinical characteristics, diagnosis and treatment of esthesioneuroblastoma (ENB).
  • METHODS: The clinical data of 7 patients with ENB were analyzed retrospectively, and the clinical characteristics, diagnosis, surgical approaches and prognosis of the disease were discussed.
  • CONCLUSION: Early diagnosis of ENB can be difficult.
  • Transnasal-frontal approach with nasal endoscope is effective approach to ENB treatment, and the patients may benefit from postoperative radiotherapy and chemotherapy to improve the prognosis.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Nose Neoplasms. Paranasal Sinus Neoplasms
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Nasal Cavity. Retrospective Studies. Young Adult

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  • (PMID = 20965857.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Woźniak MA, Dobrzyński P, Gutowska A: [Olfactory neuroblastoma in 55 year old woman]. Pol Merkur Lekarski; 2005 Sep;19(111):440-1
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  • [Title] [Olfactory neuroblastoma in 55 year old woman].
  • [Transliterated title] Nerwiak wechowy zarodkowy u 55 letniej kobiety.
  • In this article the authors describe a rare case of olfactory neuroblastoma in a 55-year-old woman surgically treated because of nasal polyposis.
  • Three years earlier she had been operated for nasal polyposis on the same side in another ENT department.
  • In histopathological examination it was confirmed to be olfactory neuroblastoma.
  • The tumor was classified as stage B in Kadish classification of olfactory neuroblastoma.
  • The histopathologic diagnosis and CT scan made after the surgery resulted in necessity of further oncological treatment.
  • The olfactory neuroblastoma is rare, difficult to diagnose, malignant, slowly growing tumor arising from the olfactory epithelium in the upper nasal cavity.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Nasal Polyps. Nose Neoplasms
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16358902.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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38. Rischin D, Coleman A: Sinonasal malignancies of neuroendocrine origin. Hematol Oncol Clin North Am; 2008 Dec;22(6):1297-316, xi
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  • The sinonasal malignancies of putative neuroendocrine origin-esthesioneuroblastoma, sinonasal neuroendocrine carcinoma, sinonasal undifferentiated carcinoma, and sinonasal small cell carcinoma-are uncommon malignancies that frequently present with locally advanced disease.

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  • (PMID = 19010275.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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39. Díez-Villalba R, González-Ruiz M, Izquierdo-Vázquez C, Molina-Quirós C, Colmenero-Ruiz M, Ramos-Amador A, Jordano-Luna L, Mora-de-Oñate J, Sanz-Fernández R: [Ophthalmic presentation of two cases of esthesioneuroblastoma]. Arch Soc Esp Oftalmol; 2008 May;83(5):317-20
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  • [Title] [Ophthalmic presentation of two cases of esthesioneuroblastoma].
  • [Transliterated title] Debut oftalmológico de dos casos de estesioneuroblastoma.
  • PURPOSE/METHOD: To report the ophthalmologic presentation of two cases of esthesioneuroblastoma (ENB).
  • A paranasal sinus mass was biopsied in one case and a nasal mass biopsied in the other.
  • ENB is a rare malignant tumour and its presentation with ophthalmologic symptoms and signs is very infrequent.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / complications. Nasal Cavity. Nose Neoplasms / complications

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  • (PMID = 18464181.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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40. Sajko T, Rumboldt Z, Talan-Hranilovic J, Radic I, Gnjidic Z: Primary sellar esthesioneuroblastoma. Acta Neurochir (Wien); 2005 Apr;147(4):447-8; discussion 448
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  • [Title] Primary sellar esthesioneuroblastoma.
  • We describe an extremely rare case of a primary intrasellar esthesioneuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Pituitary Neoplasms

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  • (PMID = 15711771.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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41. Ozer E, Bapna S, Agrawal A, Schuller DE: Maxillary removal and reinsertion: a favorable approach for extensive anterior cranial base tumors. Otolaryngol Head Neck Surg; 2010 Mar;142(3):322-6
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  • Sixty-two (80%) patients had malignant lesions.
  • The most commonly encountered malignant neoplasm was squamous cell cancer (40.3%), followed by esthesioneuroblastoma (24.1%), adenoid cystic cancer (8%), and other neoplasms (27.4%).
  • Nasal asymmetry was the most common long-term complication (17.9%), followed by plate-associated problems (10.2%) and midface asymmetry (10.2%).
  • [MeSH-minor] Adult. Aged. Child. Esthesioneuroblastoma, Olfactory / surgery. Humans. Maxilla / surgery. Middle Aged. Postoperative Complications / epidemiology. Tomography, X-Ray Computed. Young Adult

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  • [Copyright] Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20172374.001).
  • [ISSN] 1097-6817
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Freeman SR, Mitra S, Malik TH, Flanagan P, Selby P: Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory neuroblastoma--report of two cases. Rhinology; 2005 Mar;43(1):61-5
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  • [Title] Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory neuroblastoma--report of two cases.
  • OBJECTIVE: Arginine vasopressin hormone-secreting olfactory neuroblastomas are extremely rare, with fewer than twenty cases reported in the literature.
  • CONCLUSIONS: This report demonstrates the potential use of somatastatin analogues in the investigation, follow-up and treatment of patients with olfactory neuroblastoma.
  • [MeSH-major] Arginine Vasopressin / secretion. Esthesioneuroblastoma, Olfactory / metabolism. Esthesioneuroblastoma, Olfactory / secretion. Nasal Cavity. Nose Neoplasms / metabolism. Nose Neoplasms / secretion. Receptors, Somatostatin / biosynthesis

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  • (PMID = 15844504.001).
  • [ISSN] 0300-0729
  • [Journal-full-title] Rhinology
  • [ISO-abbreviation] Rhinology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Receptors, Somatostatin; 113-79-1 / Arginine Vasopressin
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43. Maeda K, Sasaki T, Murata Y, Kanasaki M, Terashima T, Kawai H, Yasuda H, Okabe H, Tanaka K: Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. J Neurol Neurosurg Psychiatry; 2006 Jan;77(1):123-4
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  • [Title] Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma.
  • [MeSH-major] Brain Neoplasms / complications. Brain Neoplasms / pathology. Neuroectodermal Tumors, Primitive, Peripheral / complications. Neuroectodermal Tumors, Primitive, Peripheral / pathology. Olfactory Pathways / pathology. Paraneoplastic Cerebellar Degeneration / complications


44. Chacón-Moya E, Gallegos-Hernández JF, Piña-Cabrales S, Cohn-Zurita F, Goné-Fernández A: Cranial vault reconstruction using computer-designed polyetheretherketone (PEEK) implant: case report. Cir Cir; 2009 Nov-Dec;77(6):437-40
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  • CLINICAL CASE: We report the case of a patient who was diagnosed with esthesioneuroblastoma and was treated with anterior craniofacial resection and radiotherapy.

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  • (PMID = 20433788.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Ketones; 30IQX730WE / Polyethylene Glycols; 31694-16-3 / polyetheretherketone
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45. Lee A, Goldstein DP, Irish J, Gentili F, Perez-Ordonez B: Noncontiguous bilateral esthesioneuroblastoma: a case report. Skull Base; 2007 Nov;17(6):405-7
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  • [Title] Noncontiguous bilateral esthesioneuroblastoma: a case report.
  • Esthesioneuroblastoma is a rare malignant neoplasm arising from the olfactory epithelium.
  • This tumor has a tendency to originate from one side of the nasal cavity or paranasal sinuses with frequent extension into the contralateral nasal cavity through direct invasion.
  • A review of the literature reveals numerous case reports describing esthesioneuroblastoma with unilateral or bilateral involvement; however, there have been no known reports of bilateral noncontiguous (multifocal) esthesioneuroblastoma.
  • We present a unique case of a patient diagnosed with two separate primary esthesioneuroblastomas who was managed with preoperative radiation followed by surgical resection of the tumor.
  • This case illustrates that esthesioneuroblastoma must remain as part of the differential diagnosis for a multifocal, noncontiguous intranasal and paranasal sinus mass.

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  • [Cites] Laryngoscope. 2001 Mar;111(3):488-93 [11224781.001]
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  • (PMID = 18449333.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2111137
  • [Keywords] NOTNLM ; Esthesioneuroblastoma / noncontiguous sinus mass / olfactory neuroblastoma
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46. Loy AH, Reibel JF, Read PW, Thomas CY, Newman SA, Jane JA, Levine PA: Esthesioneuroblastoma: continued follow-up of a single institution's experience. Arch Otolaryngol Head Neck Surg; 2006 Feb;132(2):134-8
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  • [Title] Esthesioneuroblastoma: continued follow-up of a single institution's experience.
  • OBJECTIVES: To analyze outcomes and to provide follow-up for our increasing patient cohort with esthesioneuroblastoma.
  • PATIENTS: Fifty consecutive patients diagnosed as having esthesioneuroblastoma were treated with a standardized protocol during a 28-year period.
  • Patients with tumors staged Kadish A or B received preoperative radiotherapy followed by craniofacial resection, while patients with Kadish stage C disease were treated with preoperative sequential chemotherapy and radiotherapy followed by a craniofacial resection.
  • RESULTS: The disease-free survival was 86.5% and 82.6% at 5 and 15 years, respectively.
  • There were 17 patients (34%) who developed recurrent disease, most of which was locoregional (12 patients [71%]).
  • Of these 17 patients, 7 (41%) underwent successful salvage surgery, while 3 remain alive with disease.
  • CONCLUSIONS: Excellent outcomes for esthesioneuroblastoma are achievable.
  • Long-term follow-up is necessary because of the extended interval for recurrent disease; unlike most sinonasal malignancies, surgical salvage is possible.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Esthesioneuroblastoma, Olfactory. Nasal Cavity. Neurosurgical Procedures / methods. Nose Neoplasms
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Retrospective Studies. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 16490869.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
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47. Gupta NP, Ansari MS, Nabi G: National survey on orthotopic neobladder. Int Urol Nephrol; 2007;39(1):143-8
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  • Of all institutions 12 (50%) did not prefer the orthotopic neobladder (ONB) reconstruction.

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  • (PMID = 17171422.001).
  • [ISSN] 0301-1623
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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48. Mao L, Xia YP, Zhou YN, Dai RL, Yang X, Wang YJ, Duan SJ, Qiao X, Mei YW, Hu B: Activation of sonic hedgehog signaling pathway in olfactory neuroblastoma. Oncology; 2009;77(3-4):231-43
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  • [Title] Activation of sonic hedgehog signaling pathway in olfactory neuroblastoma.
  • OBJECTIVES: Sonic hedgehog (Shh) signaling pathway is associated with tumor development; however, the role of Shh signaling in the development of olfactory neuroblastoma (ONB) is unknown.
  • This study aimed to investigate the relationship between the regulation of Shh signaling and the pathogenesis of ONB.
  • METHODS: The expression of Shh signaling components was characterized by immunohistochemistry in human non-tumor olfactory epithelium and ONB specimens, and by RT-PCR and immunoblotting in human ONB cell lines.
  • The impact of the treatment with cyclopamine (a selective inhibitor of the Shh pathway) and/or exogenous Shh on ONB cell proliferation, cycle and apoptosis was examined by MTT, soft agar colony formation and flow cytometry assays, respectively.
  • RESULTS: The expression of Pacthed1, Gli1 and Gli2 was detected in 70, 70, and 65% of human ONB specimens, respectively, and in proportion of ONB cell lines, but not in non-tumor olfactory epithelium.
  • Treatment with cyclopamine inhibited the proliferation and colony formation of ONB cells, induced ONB cell cycle arrest and apoptosis, and down-regulated the expression of Pacthed1, Gli1 and cyclin D1, but up-regulated p21 expression in vitro.
  • CONCLUSION: These data suggest that the Shh signaling pathway is crucial for the growth of ONB.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / metabolism. Hedgehog Proteins / physiology. Nasal Cavity. Nose Neoplasms / metabolism. Signal Transduction / physiology


49. Kitagawa M, Okada M, Yamamura H, Kanayama K, Sakai T: Diagnosis of olfactory neuroblastoma in a dog by magnetic resonance imaging. Vet Rec; 2006 Aug 26;159(9):288-9
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  • [Title] Diagnosis of olfactory neuroblastoma in a dog by magnetic resonance imaging.
  • [MeSH-major] Dog Diseases / diagnosis. Esthesioneuroblastoma, Olfactory / veterinary. Magnetic Resonance Imaging / veterinary. Nasal Cavity / pathology. Nose Neoplasms / veterinary
  • [MeSH-minor] Animals. Diagnosis, Differential. Dogs. Fatal Outcome. Female. Seizures / diagnosis. Seizures / etiology. Seizures / veterinary

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  • (PMID = 16946314.001).
  • [ISSN] 0042-4900
  • [Journal-full-title] The Veterinary record
  • [ISO-abbreviation] Vet. Rec.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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50. Bist SS, Kumar R, Saxena RK, Gupta C: Esthesioneuroblastoma: A case report and review of the literature. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):294-7
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  • [Title] Esthesioneuroblastoma: A case report and review of the literature.
  • Esthesioneuroblastoma (ENB) is an extremely rare malignant neoplasm of the nasal cavity.
  • We report the case of a middle aged man who presented with a 6-months history of progressive nasal obstruction, watering of the eye, headache and occasional epistaxis.
  • A diagnosis of esthesioneuroblastoma was established by histopathology and confirmed by immunohistochemistry.

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  • (PMID = 23120321.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450429
  • [Keywords] NOTNLM ; Esthesioneuroblastoma / immunohistochemistry
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51. Devaiah AK, Andreoli MT: Treatment of esthesioneuroblastoma: a 16-year meta-analysis of 361 patients. Laryngoscope; 2009 Jul;119(7):1412-6
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  • [Title] Treatment of esthesioneuroblastoma: a 16-year meta-analysis of 361 patients.
  • OBJECTIVES/HYPOTHESIS: This study reviews the published outcomes related to surgical (open, endoscopic, and endoscopic-assisted) and nonsurgical treatment for esthesioneuroblastoma.
  • METHODS: A meta-analysis of individual patient data for esthesioneuroblastoma publications between 1992 (the earliest identified description of endoscopic resection) and 2008 was conducted.
  • A total of 49 journal articles, comprising 1,170 cases of esthesioneuroblastoma, were included in the study.
  • [MeSH-major] Endoscopy. Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity. Nose Neoplasms / surgery
  • [MeSH-minor] Humans. Neoplasm Staging. Statistics, Nonparametric. Survival Analysis


52. Wang SL, Li SH, Chen WT, Chai CY: Absence of Epstein-Barr virus in olfactory neuroblastoma. Pathology; 2007 Dec;39(6):565-6
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  • [Title] Absence of Epstein-Barr virus in olfactory neuroblastoma.
  • AIMS: The sinonasal region is a frequent site for Epstein-Barr virus (EBV) related tumours, including nasopharyngeal carcinoma, sinonasal undifferentiated carcinoma and malignant lymphoma.
  • Olfactory neuroblastoma is a rare neoplasm, arises from olfactory epithelium, is found in the upper nasal cavity, and may be confused morphologically with the above tumours.
  • Our aim was to determine whether EBV is associated with olfactory neuroblastoma.
  • METHODS: We collected tissue samples for 16 olfactory neuroblastomas over an 11-year period at Kaohsiung Medical University Hospital.
  • RESULTS: None of the epithelial cells in the 16 cases of olfactory neuroblastoma was positive for EBV.
  • CONCLUSIONS: EBV does not play a major role in the aetiology of olfactory neuroblastoma.
  • [MeSH-major] Epstein-Barr Virus Infections / pathology. Esthesioneuroblastoma, Olfactory / secondary. Herpesvirus 4, Human / isolation & purification. Nasal Cavity / pathology. Nose Neoplasms / pathology

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  • (PMID = 18027259.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Viral
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53. Myssiorek D, Tronco G: 111Indium pentetreotide imaging in the evaluation of head and neck tumors. Laryngoscope; 2005 Oct;115(10):1707-16
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  • OBJECTIVES/HYPOTHESIS: Peptide receptor imaging with Indium pentetreotide is useful in the diagnosis of diffuse neuroendocrine system tumors (DNEST) of the head and neck.
  • CONCLUSIONS: Indium pentetreotide scintigraphy is accurate in determining the presence of paragangliomas, carcinoid tumors, esthesioneuroblastomas, small cell neuroendocrine tumors, andmetastases.

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  • (PMID = 16222183.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indium Radioisotopes; 0 / Radiopharmaceuticals; 0 / Receptors, Somatostatin; 51110-01-1 / Somatostatin; G083B71P98 / pentetreotide
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54. Sołtys J, Pietniczka-Załeska M, Młyńczyk-Budzynowska K, Majkowski J: [Neoplasms of paranasal sinuses in material of ENT Department MSS Hospital in Warsaw between 2006-2007]. Otolaryngol Pol; 2008;62(4):451-4
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  • [Title] [Neoplasms of paranasal sinuses in material of ENT Department MSS Hospital in Warsaw between 2006-2007].
  • Tumors of paranasal sinuses present a small percent of tumors detected in the region of head and neck 3-4% and they present a fraction of a percent of tumors in general /0.16%/.
  • MATERIAL: In the years 2004 and 2005, the National Register of Neoplasms recorded 120 and 132 cases of malignant tumors of paranasal sinuses, respectively.
  • Between 2006-2007 we treated 15 patients with tumors of paranasal sinuses underwent treatment at the ENT department of the MiEdzyleski Szpital Specjalistyczny in Warsaw.
  • THE RESULTS: We detected the following:--benign neoplasms: 2 cases of angiofibroma, 3 cases of inverted papilloma;--malignant tumors: 4 cases of Ca planoepitheliale, 1 instance of adenocarcinoma, 1 instance of Ca anaplasticum, 1--melanoma, 1--esthesioneuroblastoma, 1--lymphoma malignum, 1--metastatic tumor.
  • THE CONCLUSIONS: at the moment of the admission for treatment at the ENT department, the advancement stage of tumor T3/T4, from the first signs until the proper diagnosis was that marked with the passage of eight months.
  • Ca planoepitheliale is the most common type of malignant tumors of paranasal sinuses.
  • It is only good cooperation between the surgeon and the pathologist which makes it possible to put the proper diagnosis.
  • [MeSH-major] Carcinoma / diagnosis. Nose Neoplasms / diagnosis. Paranasal Sinus Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Hospitals, Public. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Otorhinolaryngologic Surgical Procedures / methods. Poland. Retrospective Studies. Treatment Outcome

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  • (PMID = 18837222.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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55. Shukla RC, Singh PK, Senthil S, Pathak R: Esthesioneuroblastoma: a case report. Nepal Med Coll J; 2010 Jun;12(2):128-32
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  • [Title] Esthesioneuroblastoma: a case report.
  • Esthesioneuroblastoma (olfactory neuroblastoma) is an uncommon neuroectodermal tumor.
  • Patients often present with nasal obstruction, rhinorrhea, recurrent epistaxis, hyposmia, or anosmia.
  • We report a case of esthesioneuroblastoma involving bilateral nasal cavity leading to bilateral nasal obstruction, epistaxis and proptosis of the right eye associated with decreased visual acquity on that eye and loss of smell.
  • A diffuse nontender, 6x6 cms swelling with illdefined margins was seen over the nasal bridge, extending superiorly to glabella and laterally to right maxillary region.
  • X-ray PNS showed soft tissue mass in the nasal cavity with destruction of nasal septum, intense periosteal reaction with destruction of right maxillary wall and extension to right orbit.
  • CT scan of paranasal sinuses showed 8.5 x 4.9 x 7.8 cms irregularly marginated heterogeneous iso- to hyper dense soft tissue mass lesion with extensive adjacent bony destruction and spiculated periosteal reaction involving bilateral nasal cavity and anterior cranial fossa.
  • Biopsy from right nasal mass showed neuroblastoma.
  • The modified Kadish staging system, lymph node status, treatment modality, and age are useful predictors of survival in patients who present with esthesioneuroblastoma.
  • Excellent outcomes for esthesioneuroblastoma are achievable.
  • Long-term follow-up is necessary because of the extended interval for recurrent disease; unlike most sinonasal malignancies, surgical salvage is possible.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Nasal Cavity. Nose Neoplasms
  • [MeSH-minor] Adult. Combined Modality Therapy. Humans. Male. Nasal Obstruction / etiology. Tomography, X-Ray Computed

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  • (PMID = 21222414.001).
  • [Journal-full-title] Nepal Medical College journal : NMCJ
  • [ISO-abbreviation] Nepal Med Coll J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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56. Benfari G, Fusconi M, Ciofalo A, Gallo A, Altissimi G, Celani T, De Vincentiis M: Radiotherapy alone for local tumour control in esthesioneuroblastoma. Acta Otorhinolaryngol Ital; 2008 Dec;28(6):292-7
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  • [Title] Radiotherapy alone for local tumour control in esthesioneuroblastoma.
  • Esthesioneuroblastoma is an uncommon tumour.
  • Due to its low incidence, this neoplasm is difficult to evaluate and its treatment remains a matter of debate.
  • With reference to the treatment of esthesioneuroblastoma, 55 patients submitted only to radiotherapy have been selected from publications of internationally indexed literature between 1979 and 2006.
  • There was no evidence of disease in: 6/6 stage A patients with a median follow-up period of 103.6 months, 7/12 stage B patients with a median followup period of 120 months, and 7/37 stage C patients with a median follow-up period of 77.3 months.
  • A total of 27 patients died due to tumour-related causes and 5 due to intercurrent disease, while 3 patients were alive with disease (local recurrence and cervical lymph node metastasis).
  • In conclusion, esthesioneuroblastoma is a malignant tumour which grows both locoregionally and distantly.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / radiotherapy. Nasal Cavity. Nose Neoplasms / radiotherapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Time Factors. Treatment Failure. Treatment Outcome

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  • [Cites] Int J Radiat Oncol Biol Phys. 2001 Jan 1;49(1):155-60 [11163509.001]
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  • (PMID = 19205593.001).
  • [ISSN] 0392-100X
  • [Journal-full-title] Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale
  • [ISO-abbreviation] Acta Otorhinolaryngol Ital
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 20
  • [Other-IDs] NLM/ PMC2689543
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57. Ozsahin M, Gruber G, Olszyk O, Karakoyun-Celik O, Pehlivan B, Azria D, Roelandts M, Kaanders JH, Cengiz M, Krengli M, Matzinger O, Zouhair A: Outcome and prognostic factors in olfactory neuroblastoma: a rare cancer network study. Int J Radiat Oncol Biol Phys; 2010 Nov 15;78(4):992-7
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  • [Title] Outcome and prognostic factors in olfactory neuroblastoma: a rare cancer network study.
  • PURPOSE: To assess the outcome in patients with olfactory neuroblastoma (ONB).
  • METHODS AND MATERIALS: Seventy-seven patients treated for nonmetastatic ONB between 1971 and 2004 were included.
  • Sixty-eight patients presented with N0 (88%) disease.
  • The 5-year overall survival (OS), disease-free survival (DFS), locoregional control, and local control were 64%, 57%, 62%, and 70%, respectively.
  • In univariate analyses, favorable factors were Kadish A or B disease, T1-T3 tumors, no nodal involvement, curative surgery, R0/R1 resection, and RT-dose 54 Gy or higher.
  • CONCLUSION: In this multicenter retrospective study, patients with ONB treated with R0 or R1 surgical resection followed by at least 54-Gy postoperative RT had the best outcome.
  • Novel strategies including concomitant chemotherapy and/or higher dose RT should be prospectively investigated in this rare disease for which local failure remains a problem.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / therapy. Nose Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Combined Modality Therapy / methods. Disease-Free Survival. Female. Humans. Male. Middle Aged. Nasal Cavity / pathology. Neoplasm Staging. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20231062.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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58. Chen YF, Yang AK, Zhang Q, Ouyang D, Chen WK, Chen FJ: [Clinical analysis of 53 cases of esthesioneuroblastoma]. Ai Zheng; 2009 Mar;28(3):308-11
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  • [Title] [Clinical analysis of 53 cases of esthesioneuroblastoma].
  • BACKGROUND AND OBJECTIVE: The prognosis of esthesioneuroblastoma (ENB) patients is poor.
  • CONCLUSIONS: ENB is a malignant tumor with high rates of locoregional recurrence and distant metastasis.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity. Nose Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Child. Combined Modality Therapy. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Radiotherapy, High-Energy. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 19619448.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Liao H, Hua QQ, Wu ZY: [Maxillary swing approach in the management of tumors in the central and lateral cranial base]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Apr;41(4):276-80
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  • Among them, five suffered from chordoma, two had rhabdomyosarcoma, two had squamous cell carcinoma, one had malignant fibrous histiocytoma, one had malignant melanoma, one had esthesioneuroblastoma, one had invaded hypophysoma, two had schwannoma, one had pleomorphic adenoma, and one had angiofibroma.
  • Of the 12 malignant tumors, the 1-and 2-year survival rate were 91.67% and 72.92%, respectively.

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  • (PMID = 16848177.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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60. Sharma S, Lasheen W, Walsh D: Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma. Rhinology; 2008 Jun;46(2):153-5
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  • [Title] Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma.
  • Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory neuroepithelium.
  • ENB has no distinctive clinical picture, but often presents as chronic unilateral nasal obstruction or epistaxis.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / secondary. Hypercalcemia / etiology. Nasal Cavity. Nose Neoplasms / pathology. Paraneoplastic Syndromes / etiology


61. Lund V, Howard DJ, Wei WI: Endoscopic resection of malignant tumors of the nose and sinuses. Am J Rhinol; 2007 Jan-Feb;21(1):89-94
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  • [Title] Endoscopic resection of malignant tumors of the nose and sinuses.
  • However, the rarity and long natural history of malignant tumors make it difficult to accrue cohorts comparable with the established gold standard of craniofacial resection.
  • METHODS: In this prospective cohort study, after histological confirmation and a staging imaging protocol, patients deemed suitable were offered the option of an entirely endoscopic resection as an alternative to craniofacial resection.
  • A wide range of pathologies included 15 cases of adenocarcinoma, 11 malignant melanomas, and 11 olfactory neuroblastomas.
  • Thirty-six patients are alive and well, 7 patients have residual disease, 4 patients are dead of disease, and 2 patients have died of intercurrent disease.
  • [MeSH-major] Endoscopy / methods. Nose Neoplasms / surgery. Paranasal Sinus Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Length of Stay. Magnetic Resonance Imaging. Male. Middle Aged. Prospective Studies. Survival Rate. Time Factors. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17283568.001).
  • [ISSN] 1050-6586
  • [Journal-full-title] American journal of rhinology
  • [ISO-abbreviation] Am J Rhinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Madani I, Bonte K, Vakaet L, Boterberg T, De Neve W: Intensity-modulated radiotherapy for sinonasal tumors: Ghent University Hospital update. Int J Radiat Oncol Biol Phys; 2009 Feb 1;73(2):424-32
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  • The tumor histologic type was adenocarcinoma in 54, squamous cell carcinoma in 17, esthesioneuroblastoma in 9, and adenoid cystic carcinoma in 4.
  • The tumors were located in the ethmoid sinus in 47, maxillary sinus in 19, nasal cavity in 16, and multiple sites in 2.
  • The 5-year local control, overall survival, disease-specific survival, disease-free survival, and freedom from distant metastasis rate was 70.7%, 58.5%, 67%, 59.3%, and 82.2%, respectively.
  • [MeSH-major] Nose Neoplasms / radiotherapy. Paranasal Sinus Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Hospitals, University. Humans. Male. Middle Aged. Multivariate Analysis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / radiotherapy. Radiotherapy Dosage. Survival Rate. Treatment Outcome

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  • (PMID = 18755554.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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63. Gore MR, Zanation AM: Salvage treatment of late neck metastasis in esthesioneuroblastoma: a meta-analysis. Arch Otolaryngol Head Neck Surg; 2009 Oct;135(10):1030-4
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  • [Title] Salvage treatment of late neck metastasis in esthesioneuroblastoma: a meta-analysis.
  • OBJECTIVE: Esthesioneuroblastoma (ENB) is an uncommon tumor of the sinonasal region with a 20% rate of neck metastases.
  • To our knowledge, the rate of neck metastases occurring 6 or more months after diagnosis has not been well characterized.
  • The rate of successful salvage of these late neck metastases, defined in this study as disease-free survival for at least 1 year, has not been previously reported.
  • PATIENTS: A total of 678 patients with ENB with 79 patients with neck metastases occurring 6 or more months after the initial diagnosis.
  • MAIN OUTCOME MEASURES: The rate of successful salvage of late neck metastases, defined as disease-free survival for at least 1 year, was compared for the 3 treatment groups.
  • An odds ratio (OR) analysis revealed that surgery plus radiation provided a statistically significant increase in the rate of successful salvage in patients with late neck metastases, with an OR of 8.6 vs single modality therapy and a number-needed-to-treat of 3.
  • CONCLUSION: Treatment of neck metastases occurring 6 or more months after an initial diagnosis of ENB with combined surgery and radiotherapy provides a statistically significant survival advantage vs single-modality therapy.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / pathology. Head and Neck Neoplasms / secondary. Head and Neck Neoplasms / therapy. Nasal Cavity / pathology. Nose Neoplasms / pathology. Salvage Therapy / methods

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  • (PMID = 19841344.001).
  • [ISSN] 1538-361X
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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64. Diaz EM Jr, Johnigan RH 3rd, Pero C, El-Naggar AK, Roberts DB, Barker JL, DeMonte F: Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center. Head Neck; 2005 Feb;27(2):138-49
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  • [Title] Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center.
  • BACKGROUND: Olfactory neuroblastoma (ONB) is a rare tumor arising from the olfactory neuroepithelium.
  • METHODS: Thirty patients treated for ONB at The University of Texas M. D.
  • The diagnosis of ONB was histologically confirmed for each patient.
  • Nine patients whose disease was initially stage C had a recurrence.
  • Anderson Cancer Center approach to ONB is complete surgical resection, usually involving a craniofacial approach, with postoperative radiation therapy.
  • This approach seems to be curative in early-stage disease.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / diagnosis. Esthesioneuroblastoma, Olfactory / therapy. Nasal Cavity. Nose Neoplasms / diagnosis. Nose Neoplasms / therapy
  • [MeSH-minor] Academic Medical Centers. Adolescent. Adult. Aged. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Texas. Treatment Outcome

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  • [Copyright] 2004 Wiley Periodicals, Inc.
  • (PMID = 15654688.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Lin JH, Tsai DH, Chiang YH: A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures. Pituitary; 2009;12(1):70-5
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  • [Title] A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures.
  • The development of an esthesioneuroblastoma outside to the region in which olfactory epithelium exists is extremely rare.
  • The author presents a 40 years-old man with ectopic esthesioneuroblastoma in sella turcica.
  • Moreover, differential diagnosis and the origin of the ectopic esthsioneuroblastoma would be discussed.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / pathology. Sella Turcica / pathology

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  • (PMID = 18176843.001).
  • [ISSN] 1573-7403
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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66. Sharma NK, Pandey J, Gupta N, Jain RK: Growth and physiological response of Arthrobacter protophormiae RKJ100 toward higher concentrations of o-nitrobenzoate and p-hydroxybenzoate. FEMS Microbiol Lett; 2007 Jun;271(1):65-70
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  • In the present study we have characterized the growth response and physiological changes (adaptations) of a Gram-positive bacterium, Arthrobacter protophormiae RKJ100, toward the higher concentrations of two aromatic compounds, viz. o-nitrobenzoate (ONB) and p-hydroxybenzoate (PHB).
  • Arthrobacter protophormiae RKJ100 could utilize 30 mM ONB and 50 mM PHB as sole sources of carbon and energy.
  • It was capable of growth on higher concentrations of ONB (up to 200 mM) and PHB (up to 150 mM) when the cells were pre-exposed to lower concentrations of these compounds.
  • In addition, Bacterial Adhesion To Hydrocarbon (BATH) assay and scanning electron microscopy showed substantial increase in cell surface hydrophobicity and decrease in cell size of A. protophormiae RKJ100 when grown on ONB and PHB as compared to succinate-grown cells.

  • Hazardous Substances Data Bank. SUCCINIC ACID .
  • Hazardous Substances Data Bank. CARBON .
  • Hazardous Substances Data Bank. 4-HYDROXYBENZOIC ACID .
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  • (PMID = 17391368.001).
  • [ISSN] 0378-1097
  • [Journal-full-title] FEMS microbiology letters
  • [ISO-abbreviation] FEMS Microbiol. Lett.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-nitrobenzoate; 0 / Fatty Acids; 0 / Nitrobenzoates; 0 / Parabens; 7440-44-0 / Carbon; AB6MNQ6J6L / Succinic Acid; JG8Z55Y12H / 4-hydroxybenzoic acid
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67. Daly ME, Chen AM, Bucci MK, El-Sayed I, Xia P, Kaplan MJ, Eisele DW: Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses. Int J Radiat Oncol Biol Phys; 2007 Jan 1;67(1):151-7
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  • [Title] Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses.
  • PURPOSE: To report the clinical outcome of patients treated with intensity-modulated radiation therapy (IMRT) for malignancies of the nasal cavity and paranasal sinuses.
  • The primary sites were: 13 ethmoid sinus, 10 maxillary sinus, 7 nasal cavity, and 6 other.
  • Histology was: 12 squamous cell, 7 esthesioneuroblastoma, 5 adenoid cystic, 5 undifferentiated, 5 adenocarcinoma, and 2 other.
  • The 5-year rates of disease-free and overall survival were 55% and 45%, respectively.
  • CONCLUSION: Although IMRT for malignancies of the sinonasal region does not appear to lead to significant improvements in disease control, the low incidence of complications is encouraging.
  • [MeSH-major] Nose Neoplasms / radiotherapy. Paranasal Sinus Neoplasms / radiotherapy. Radiotherapy, Intensity-Modulated
  • [MeSH-minor] Adenocarcinoma / radiotherapy. Adenocarcinoma / secondary. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / radiotherapy. Carcinoma, Adenoid Cystic / secondary. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / secondary. Esthesioneuroblastoma, Olfactory / radiotherapy. Esthesioneuroblastoma, Olfactory / secondary. Female. Humans. Male. Middle Aged. Nasal Cavity. Neoplasm Staging. Radiation Injuries / etiology. Radiotherapy Dosage

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  • (PMID = 17189068.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Kryzanski JT, Annino DJ, Gopal H, Heilman CB: Low complication rates of cranial and craniofacial approaches to midline anterior skull base lesions. Skull Base; 2008 Jul;18(4):229-41
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  • The remainder had frontoethmoidal cancer, mucoceles/invasive nasal polyps, encephalocele, esthesioneuroblastoma, anterior falx dermoid cyst with a nasal sinus tract, or invasive pituitary adenoma.
  • When possible, the dura was repaired before entering the nasal cavity.

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  • (PMID = 19119338.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2467480
  • [Keywords] NOTNLM ; Anterior skull base / cerebrospinal fluid leak / complications / craniofacial approach / meningioma / skull base surgery
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69. Wang SY, Zhu L, Li SM, Lin L, Zheng SX, Wu YF, Zhu XZ: [Sinonasal teratocarcinosarcoma: a clinical, radiologic and pathologic study of 5 cases]. Zhonghua Bing Li Xue Za Zhi; 2007 Aug;36(8):534-8
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  • OBJECTIVE: To study the clinical, radiologic and pathologic features, as well as differential diagnosis of teratocarcinosarcoma in nasal cavity and paranasal sinuses.
  • The clinical presentation was nasal obstruction, epistaxis and headache.
  • Computed tomography showed a homogeneous nasal mass with obturation of sinuses.
  • The initial biopsy diagnosis included capillary hemangioma, olfactory neuroblastoma, craniopharyngioma and malignant mixed tumor.
  • CONCLUSIONS: Sinonasal teratocarcinosarcoma is a rare and highly malignant tumor occurring in sinonasal tract.
  • "Fetal-type" clear cells, squamous epithelium and immature neuroepithelium represent important histologic characteristics useful in diagnosis.
  • [MeSH-major] Carcinosarcoma / pathology. Nasal Cavity. Nose Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology. Teratocarcinoma / pathology
  • [MeSH-minor] Adult. Follow-Up Studies. Humans. Keratins / metabolism. Lymphatic Metastasis. Male. Mucin-1 / metabolism. Neck Dissection. Neoplasm Recurrence, Local

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  • (PMID = 17980101.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Mucin-1; 68238-35-7 / Keratins
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70. Zafereo ME, Fakhri S, Prayson R, Batra PS, Lee J, Lanza DC, Citardi MJ: Esthesioneuroblastoma: 25-year experience at a single institution. Otolaryngol Head Neck Surg; 2008 Apr;138(4):452-8
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  • [Title] Esthesioneuroblastoma: 25-year experience at a single institution.
  • OBJECTIVES: To evaluate outcomes for patients with esthesioneuroblastoma treated at a single institution during a 25-year period.
  • DESIGN: Eighteen patients with pathologic diagnosis of esthesioneuroblastoma between 1980 and 2004 were retrospectively identified.
  • RESULTS: Two patients had Kadish A, seven had Kadish B, and nine had Kadish C disease.
  • The 10-year disease-specific survival was 80%.
  • CONCLUSION: Both endoscopic and open surgical approaches have been successful in treating a small number of esthesioneuroblastoma patients with high survival and low rate of surgical complications.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity. Nose Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Humans. Male. Middle Aged. Neck Dissection. Radiation Dosage. Retrospective Studies

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  • (PMID = 18359353.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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71. Schwartz TH, Fraser JF, Brown S, Tabaee A, Kacker A, Anand VK: Endoscopic cranial base surgery: classification of operative approaches. Neurosurgery; 2008 May;62(5):991-1002; discussion 1002-5
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  • METHODS: We prospectively compiled a comprehensive database of our endonasal endoscopic operations, detailing the nasal sinus transgressed, the cranial base approach, and the intracranial target for the first 150 consecutive cases performed at our institution.
  • RESULTS: We categorized the endonasal endoscopic cranial base operations into four nasal corridors, nine cranial base approaches, and 13 intracranial targets.
  • Pathology encountered included pituitary tumor (50%), meningocele/encephalocele (14%), craniopharyngioma and Rathke cleft cyst (10%), meningioma (8%), chordoma (5%), esthesioneuroblastoma (2%), and other (11%).
  • A clear understanding of the possible approaches is facilitated by an awareness of the nasal corridors and intracranial targets.
  • [MeSH-minor] Female. Humans. Male. Nasal Cavity / surgery

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  • (PMID = 18580797.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Kalala L, Focan C, Schils F, Gilles R, Abraham F, Reginster P, Van Den Berge D: [Esthesioneuroblastoma: a case report and literature review]. Rev Med Liege; 2009 Mar;64(3):119-23
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  • [Title] [Esthesioneuroblastoma: a case report and literature review].
  • [Transliterated title] Esthésioneuroblastome: à propos d'un cas et revue de la littérature.
  • Esthesioneuroblastoma (ENB) or olfactive neuroblastoma is a rare cancer arising from the neuroepithelium of the olfactory epithelium of the nasal cavity.
  • The anatomopathological diagnosis will frequently require immuno-histochemical tests and sometimes electron-microscopy as well as genetic testing.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Nasal Cavity. Nose Neoplasms

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  • (PMID = 19418930.001).
  • [ISSN] 0370-629X
  • [Journal-full-title] Revue médicale de Liège
  • [ISO-abbreviation] Rev Med Liege
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 18
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73. Casiraghi O, Lefèvre M: [Undifferentiated malignant round cell tumors of the sinonasal tract and nasopharynx]. Ann Pathol; 2009 Sep;29(4):296-312
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  • [Title] [Undifferentiated malignant round cell tumors of the sinonasal tract and nasopharynx].
  • [Transliterated title] Tumeurs malignes indifférenciées à cellules rondes des cavités naso-sinusiennes et du nasopharynx.
  • Undifferentiated malignant round cell tumors of the sinonasal tract and nasopharynx comprise of aggressive malignant neoplasms with overlapping morphologic features, which yet are very different and can be identified as carcinoma, lymphoma, sarcoma, melanoma or olfactory neuroblastoma.
  • The use of a panel of immunohistochemical markers and the identification, in some cases, of specific chromosomal translocations are most often required.
  • We describe clinical, morphological, immunohistochemical and molecular features as well as therapeutic management and prognosis of rhabdomyosarcoma (RMS), Ewing sarcoma/primitive neuroectodermic tumor (EWS/PNET), nonkeratinizing nasopharyngeal carcinoma, undifferentiated subtype (UCNT), olfactory neuroblastoma (ONB), small cell carcinoma, neuroendocrine type (SCCNET), sinonasal undifferentiated carcinoma (SNUC) and mucosal melanoma.
  • The most important features of diagnosis will be summarized in two tables.
  • [MeSH-major] Nasopharyngeal Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology
  • [MeSH-minor] Carcinoma / pathology. Esthesioneuroblastoma, Olfactory / pathology. Humans. Melanoma / pathology. Nasal Cavity. Neuroectodermal Tumors, Primitive / pathology. Nose Neoplasms / pathology. Rhabdomyosarcoma / pathology. Sarcoma, Ewing / pathology

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  • (PMID = 19900635.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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74. Han A, Kristjansson AK, Gilliam AC, Jacobs G, Eisenberg R: Pigmented olfactory neuroblastoma: a CD56-positive mimic of melanoma. Arch Dermatol; 2008 Feb;144(2):270-2
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  • [Title] Pigmented olfactory neuroblastoma: a CD56-positive mimic of melanoma.
  • [MeSH-major] Antigens, CD56 / analysis. Esthesioneuroblastoma, Olfactory / diagnosis. Esthesioneuroblastoma, Olfactory / immunology. Melanoma / diagnosis. Nasal Cavity. Nose Neoplasms / immunology
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Male

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  • (PMID = 18283196.001).
  • [ISSN] 1538-3652
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / P30-AR 39750; United States / NIAMS NIH HHS / AR / R01 AR 049284
  • [Publication-type] Case Reports; Letter; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56
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75. Sahai-Srivastava S, Subhani D: Adverse effect profile of lidocaine injections for occipital nerve block in occipital neuralgia. J Headache Pain; 2010 Dec;11(6):519-23
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  • To determine whether there are differences in the adverse effect profile between 1, 2 and 5% Lidocaine when used for occipital nerve blocks (ONB) in patients with occipital neuralgia.
  • Retrospective chart analysis of all ONB was performed at our headache clinic during a 6-year period on occipital neuralgia patients.
  • 89 consecutive patients with occipital neuralgia underwent a total of 315 ONB.
  • ONB is a safe procedure with 1% Lidocaine; however, caution should be exerted with 5% in elderly patients, 70 or older, especially when administering bilateral injections.

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  • (PMID = 20665065.001).
  • [ISSN] 1129-2377
  • [Journal-full-title] The journal of headache and pain
  • [ISO-abbreviation] J Headache Pain
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 98PI200987 / Lidocaine
  • [Other-IDs] NLM/ PMC3476234
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76. Folbe A, Herzallah I, Duvvuri U, Bublik M, Sargi Z, Snyderman CH, Carrau R, Casiano R, Kassam AB, Morcos JJ: Endoscopic endonasal resection of esthesioneuroblastoma: a multicenter study. Am J Rhinol Allergy; 2009 Jan-Feb;23(1):91-4
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  • [Title] Endoscopic endonasal resection of esthesioneuroblastoma: a multicenter study.
  • BACKGROUND: This study reports the combined experience of the University of Miami and University of Pittsburgh with endoscopic endonasal resection of esthesioneuroblastoma (ENB).
  • The two other cases had one patient that required an additional craniotomy approach to complete the resection of a positive lateral dual margin, another patient had positive margins at the orbital apex.
  • Mean follow-up period for the primarily treated cases was 45.2 months (11-152 months), all were disease free at the most recent available follow-up.
  • [MeSH-major] Endoscopy / methods. Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity. Nose Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Treatment Outcome. Young Adult

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  • [ErratumIn] Am J Rhinol Allergy. 2009 Mar-Apr;23(2):238. Kassam, Amin Bardai [added]; Morcos, Jacques J [added]
  • (PMID = 19379620.001).
  • [ISSN] 1945-8924
  • [Journal-full-title] American journal of rhinology & allergy
  • [ISO-abbreviation] Am J Rhinol Allergy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] United States
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77. Castelnuovo P, Bignami M, Delù G, Battaglia P, Bignardi M, Dallan I: Endonasal endoscopic resection and radiotherapy in olfactory neuroblastoma: our experience. Head Neck; 2007 Sep;29(9):845-50
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  • [Title] Endonasal endoscopic resection and radiotherapy in olfactory neuroblastoma: our experience.
  • BACKGROUND: Our aim was to evaluate the efficacy of a bimodal method of treatment consisting in endoscopic resection followed by radiotherapy in patients with olfactory neuroblastoma (ON).
  • CONCLUSIONS: This method of treatment causes minimal injury to the patients, reduces side effects, and improves the quality of life of those with olfactory neuroblastoma.
  • [MeSH-major] Endoscopy / methods. Esthesioneuroblastoma, Olfactory / radiotherapy. Esthesioneuroblastoma, Olfactory / surgery. Nose Neoplasms / radiotherapy. Nose Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Nasal Cavity. Quality of Life. Radiotherapy, Adjuvant. Retrospective Studies

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc. Head Neck, 2007.
  • (PMID = 17427966.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Vergani F, Pirola E, Fiori L, Pagni F, Parmigiani F, Sganzerla EP: Combined transcranial and endoscopic nasal resection for esthesioneuroblastoma. Technical note. J Neurosurg Sci; 2007 Jun;51(2):99-102
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  • [Title] Combined transcranial and endoscopic nasal resection for esthesioneuroblastoma. Technical note.
  • Esthesioneuroblastoma is a rare malignant neoplasm arising in the nasal cavity.
  • Huge esthesioneuroblastomas, extending into the ethmoid roof and the cribriform plate, or invading the anterior cranial fossa, have traditionally been treated by craniofacial resection.
  • Because of the invasiveness and potentially disfiguring results of a transfacial approach, a new technique has been proposed, combining endoscopic nasal and anterior craniotomy resection.
  • We describe the case of a young male presenting with a large esthesioneuroblastoma involving the nasal cavity and the anterior cranial fossa, causing a huge skull base destruction.
  • A combined transcranial and endoscopic nasal resection resulted in a macroscopically total removal of the tumor.
  • [MeSH-major] Cranial Fossa, Anterior / surgery. Endoscopy / methods. Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity / surgery. Neurosurgical Procedures / methods. Nose Neoplasms / surgery
  • [MeSH-minor] Adult. Blood Coagulation Disorders. Cranial Sinuses / pathology. Craniotomy / methods. Ethmoid Bone / pathology. Ethmoid Bone / surgery. Humans. Magnetic Resonance Imaging. Male. Nasal Septum / surgery. Nasal Septum / transplantation. Olfactory Mucosa / pathology. Postoperative Hemorrhage / drug therapy. Postoperative Hemorrhage / prevention & control. Reconstructive Surgical Procedures / methods. Surgical Flaps. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 17571044.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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79. Almubaslat M, Africk C: Cerebral vasospasm after resection of an esthesioneuroblastoma: case report and literature review. Surg Neurol; 2007 Sep;68(3):322-8; discussion 328
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  • [Title] Cerebral vasospasm after resection of an esthesioneuroblastoma: case report and literature review.
  • We illustrate in this report a case of cerebral vasospasm after resection of an esthesioneuroblastoma in an adult patient.
  • This is the first report of vasospasm after resection of this neoplasm.
  • Radiological studies revealed a large frontal lobe mass extending through the cribriform plate into the ethmoid sinus with accompanying brain edema.
  • The patient underwent a craniotomy for resection of the neoplasm.
  • Pathological findings were consistent with a high-grade esthesioneuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity. Nose Neoplasms / surgery. Postoperative Complications. Vasospasm, Intracranial / etiology

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  • (PMID = 17586013.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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80. Papoutsi Z, Kassi E, Halabalaki M, Mitakou S, Moutsatsou P: Evaluation of estrogenic/antiestrogenic activity of Onobrychis ebenoides extract - interaction with estrogen receptor subtypes ERalpha and ERbeta. Toxicol In Vitro; 2007 Apr;21(3):364-70
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  • To investigate the molecular mechanisms that underly the beneficial effect of O. ebenoides (Onb) on bone loss, we studied its potential to activate ER subtypes (ERalpha and ERbeta) on transiently transfected HeLa cells with HO-hERalpha or pSG5-hERbeta and 3xERE-TATA-Luc expression vectors.
  • (1) Onb extract displayed a significant estrogenic activity on both ERalpha and ERbeta subtypes. (2) It exhibited direct action on osteoblasts by inducing mineralization. (3) It showed estrogenic activity in MCF7 cells.
  • These findings suggest that the beneficial effect of Onb extract on bone loss is mediated through an estrogen-like action via activation of ERalpha-ERE and ERbeta-ERE pathways and via direct action on the mineralization process of osteoblasts.

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  • (PMID = 17092687.001).
  • [ISSN] 0887-2333
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / IGFBP3 protein, human; 0 / Insulin-Like Growth Factor Binding Protein 3; 0 / Insulin-Like Growth Factor Binding Proteins; 0 / Phytoestrogens; 0 / Plant Extracts; 22X328QOC4 / fulvestrant; 4TI98Z838E / Estradiol; EC 1.13.12.- / Luciferases
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81. Lettau M, Laible M: [Diffuse subdural recurrence of an esthesioneuroblastoma]. Rofo; 2010 Oct;182(10):907-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diffuse subdural recurrence of an esthesioneuroblastoma].
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / diagnosis. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / diagnosis. Positron-Emission Tomography. Subdural Space. Tomography, X-Ray Computed
  • [MeSH-minor] Adolescent. Biopsy. Combined Modality Therapy. Cranial Fossa, Anterior / pathology. Ethmoid Sinus / pathology. Fluorodeoxyglucose F18. Humans. Lymphatic Metastasis / pathology. Male. Maxillary Sinus / pathology. Necrosis. Neoplasm Invasiveness. Orbit / pathology

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  • (PMID = 20563963.001).
  • [ISSN] 1438-9010
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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82. Unal A, Ozlugedik S, Tezer MS, Kulacoglu S, Ozcan M: An atypical esthesioneuroblastoma of the inferior nasal cavity and maxillary sinus: report of a case. Tumori; 2006 Sep-Oct;92(5):440-3
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  • [Title] An atypical esthesioneuroblastoma of the inferior nasal cavity and maxillary sinus: report of a case.
  • Esthesioneuroblastoma is a rare malignant tumor of the nasal cavity that originates from the olfactory epithelium.
  • The tumor originated from the maxillary sinus and alveolar process, and was independent of the olfactory region.
  • The patient was a 14-year-old girl presenting with facial swelling and nasal obstruction.
  • Paranasal computed tomography showed a mass filling the right nasal cavity, infiltrating the alveolar process, eroding the anterior wall of the maxilla and invading the subcutaneous tissues of the cheek.
  • Fine-needle aspiration and incisional biopsies identified an esthesioneuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory. Maxillary Sinus Neoplasms. Nasal Cavity. Nose Neoplasms

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  • (PMID = 17168440.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 30
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83. Bachar G, Goldstein DP, Shah M, Tandon A, Ringash J, Pond G, Gullane PJ, Perez-Ordonez B, Gilbert RW, Brown DH, Gentili F, O'Sullivan B, Irish JC: Esthesioneuroblastoma: The Princess Margaret Hospital experience. Head Neck; 2008 Dec;30(12):1607-14
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  • [Title] Esthesioneuroblastoma: The Princess Margaret Hospital experience.
  • BACKGROUND: Esthesioneuroblastoma is rare.
  • Local disease control was 82.6% at 5 years.
  • Recurrence was seen in 33% with local and regional disease recurrence at 15% and 18%, respectively.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / therapy. Nasal Cavity. Neoplasm Recurrence, Local / therapy. Nose Neoplasms / therapy
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Hospitals, University. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Staging. Ontario. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18798301.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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84. Nichols AC, Chan AW, Curry WT, Barker FG, Deschler DG, Lin DT: Esthesioneuroblastoma: the massachusetts eye and ear infirmary and massachusetts general hospital experience with craniofacial resection, proton beam radiation, and chemotherapy. Skull Base; 2008 Sep;18(5):327-37
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  • [Title] Esthesioneuroblastoma: the massachusetts eye and ear infirmary and massachusetts general hospital experience with craniofacial resection, proton beam radiation, and chemotherapy.
  • OBJECTIVES: To determine the efficacy of craniofacial resection and proton radiation for the management of esthesioneuroblastoma (ENB).
  • MAIN OUTCOME MEASURES: Disease-free and overall survival.
  • Nasal obstruction was the most common presenting symptom.
  • Three patients presented with Kadish stage B disease and seven with stage C.
  • No patient had evidence of cervical or metastatic disease at presentation.
  • The 5-year disease-free and overall survival rates were 90% and 85.7%, respectively, by Kaplan-Meier analysis.

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  • [Cites] Arch Otolaryngol Head Neck Surg. 2003 Nov;129(11):1186-92 [14623748.001]
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  • (PMID = 19240832.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2637063
  • [Keywords] NOTNLM ; Esthesioneuroblastoma / craniofacial resection / proton radiation
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85. Kiprian D: [Strategy of combined treatment in patient with cancer of paranasal sinuses]. Otolaryngol Pol; 2007;61(4):527-30
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  • [Title] [Strategy of combined treatment in patient with cancer of paranasal sinuses].
  • In 2003, in Poland there were 132 new patients diagnosed for this disease.
  • There is a very rare neoplasm as a olfactory neuroblastoma in this localization.
  • Cancer of the paranasal sinuses infiltrates only locoregionally.
  • The treatment of cancers of paranasal sinuses is always surgery with adjuvant irradiation.
  • [MeSH-major] Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / therapy
  • [MeSH-minor] Combined Modality Therapy. Humans. Incidence. Neoplasm Staging. Radiotherapy, Conformal. Treatment Outcome

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  • (PMID = 18260245.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Number-of-references] 5
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86. Mandhani A, Dharaskar A, Kapoor R: Technical steps of open radical cystectomy and orthotopic neobladder to achieve the goals of "minimally invasive surgery"? Indian J Urol; 2010 Jul;26(3):457-60
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  • Technical modifications in open approach to radical cystectomy and orthotopic neobladder (ONB), that is, Pfannenstiel incision, single urethral catheter, internal splint, and extraperitonealization of the ONB were done in 36 patients.

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  • (PMID = 21116377.001).
  • [ISSN] 1998-3824
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2978457
  • [Keywords] NOTNLM ; Open radical cystectomy / laparoscopic radical cystectomy / minimally invasive surgery / robotic radical cystectomy
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87. Martin DA, Hogg JP: Illustrated approach to imaging and staging of nodal disease in the neck. Curr Probl Diagn Radiol; 2010 Mar-Apr;39(2):62-73
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  • [Title] Illustrated approach to imaging and staging of nodal disease in the neck.
  • This article provides a review of the anatomic classification and staging of nodal disease in the neck through the use of tables, illustrations, and sample imaging cases.
  • The article reinforces knowledge of nodal disease in the neck while reviewing imaging examples of common and uncommon disease entities in this region.
  • We review nodal disease in the neck using American Joint Committee on Cancer staging criteria.
  • The accompanying images and clinical scenarios aid recognition with an emphasis on differential diagnosis.
  • Case examples include a broad range of pathologically and clinically proven disease entities involving lymph node disease in the neck accumulated from 1999 to 2008 at a tertiary referral center.
  • The anatomical relationships and major disease processes for this location are reviewed and illustrated with example images from commonly used imaging modalities for this region.
  • Examples of cases discussed include lymphoma, metastatic neoplasms such as head/neck squamous cell carcinoma and esthesioneuroblastoma, and inflammatory and infectious processes such as mononucleosis.
  • The reader will gain or refresh information about the anatomical relationships and demarcations of the nodal levels of the neck as well as disease entities that frequently present with neck adenopathy.
  • The images provided aid recognition with an emphasis on clinical context and differential diagnosis.
  • A succinct review of patterns of nodal disease of the neck with anatomic orientation using illustrations of typical and atypical disease entities in this region enhance and reinforce understanding of this often complex area of imaging.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / radiography. Neoplasm Staging / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Squamous Cell / radiography. Diagnosis, Differential. Female. Giant Lymph Node Hyperplasia / diagnosis. Humans. Lymph Nodes / anatomy & histology. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Neck / anatomy & histology. Tomography, X-Ray Computed. Tongue Neoplasms / radiography

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  • [Copyright] Copyright (c) 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20113867.001).
  • [ISSN] 1535-6302
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Menon S, Pai P, Sengar M, Aggarwal JP, Kane SV: Sinonasal malignancies with neuroendocrine differentiation: case series and review of literature. Indian J Pathol Microbiol; 2010 Jan-Mar;53(1):28-34
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  • Based on their neuroendocrine differentiation they can be sub categorized into sinonasal undifferentiated carcinoma (SNUC), sinonasal neuroendocrine carcinoma (SNEC), esthesioneuroblastoma (ENB) and small cell carcinoma (SmCC).
  • Hence the histo-morphological diagnosis coupled with grading/staging is important for the prognostication of these tumors.
  • Conclusion : Sino nasal tumors with neuroendocrine differentiation are a heterogenous group of tumors with overlapping histo-morphological features.
  • [MeSH-major] Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / pathology. Paranasal Sinus Neoplasms / diagnosis. Paranasal Sinus Neoplasms / pathology

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  • (PMID = 20090218.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 18
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89. Cossairt BM, Cummins CC: Phosphaalkenes as long-lived phosphorus cluster surface functional groups: intramolecular P=C addition to a niobium-supported P7 cage. Inorg Chem; 2008 Oct 20;47(20):9363-71
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  • When 1 is treated with aryl ketones, loss of ONb(OC[(2)Ad]Mes)3(OEt2) (2) is observed along with concomitant formation of the corresponding phosphaalkene (RC6H4)2CPP7Nb(OC[(2)Ad]Mes)3 (3-R).

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  • (PMID = 18800834.001).
  • [ISSN] 1520-510X
  • [Journal-full-title] Inorganic chemistry
  • [ISO-abbreviation] Inorg Chem
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Lee JY, Kim HK: Primary olfactory neuroblastoma originating from the inferior meatus of the nasal cavity. Am J Otolaryngol; 2007 May-Jun;28(3):196-200
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  • [Title] Primary olfactory neuroblastoma originating from the inferior meatus of the nasal cavity.
  • Olfactory neuroblastoma is a rare malignant tumor of the nasal cavity arising from the olfactory neuroepithelium.
  • It usually presents as a polypoid mass high in the nasal vault including the cribriform plate, superior turbinate, and superior portion of nasal septum.
  • An 89-year-old man visited our office with symptoms of occasional left nasal bleeding and obstruction.
  • Biopsy was performed, and the diagnosis of olfactory neuroblastoma was confirmed by histopathologic examination and immunohistochemical staining.
  • The tumor was resected via medial maxillectomy, and the final pathologic report established that it was primary olfactory neuroblastoma that occurred from the inferior meatus.
  • In this report, a literature review was performed on the pathologic characteristics and prognosis of the tumor, and possible hypotheses that olfactory neuroblastoma has originated from the inferior meatus were discussed.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / pathology. Nasal Cavity / pathology. Nose Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Humans. Male. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 17499140.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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91. Sterzing F, Stoiber EM, Nill S, Bauer H, Huber P, Debus J, Münter MW: Intensity modulated radiotherapy (IMRT) in the treatment of children and adolescents--a single institution's experience and a review of the literature. Radiat Oncol; 2009;4:37
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  • [Title] Intensity modulated radiotherapy (IMRT) in the treatment of children and adolescents--a single institution's experience and a review of the literature.
  • This heterogeneous group of patients consisted of 20 different tumor entities, with Ewing's sarcoma being the largest (5 patients), followed by juvenile nasopharyngeal fibroma, esthesioneuroblastoma and rhabdomyosarcoma (3 patients each).

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  • (PMID = 19775449.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 51
  • [Other-IDs] NLM/ PMC2760561
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92. Unger F, Haselsberger K, Walch C, Stammberger H, Papaefthymiou G: Combined endoscopic surgery and radiosurgery as treatment modality for olfactory neuroblastoma (esthesioneuroblastoma). Acta Neurochir (Wien); 2005 Jun;147(6):595-601; discussion 601-2
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  • [Title] Combined endoscopic surgery and radiosurgery as treatment modality for olfactory neuroblastoma (esthesioneuroblastoma).
  • OBJECT: Treatment of esthesioneuroblastoma (olfactory neuroblastoma) has been considerably improved by microsurgical techniques.
  • A novel therapeutic approach that combines endoscopic sinus surgery and Gamma Knife radiosurgery is presented here.
  • Taking into account the rarity of the disease the present study comprises a relatively large series of patients treated in a similar manner.
  • This series comprises 12 newly diagnosed esthesioneuroblastomas.
  • Paranasal and nasal endoscopic sinus surgery was performed.
  • All patients complained of nasal discharge and crusts.
  • CONCLUSIONS: Based on the favourable results recorded so far, the combination of endoscopic sinus surgery and radiosurgery can be considered a promising treatment option for esthesioneuroblastoma that merits further consideration.
  • [MeSH-major] Endoscopy. Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity / surgery. Nose Neoplasms / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Treatment Outcome


93. Yu T, Xu YK, Li L, Jia FG, Duan G, Wu YK, Li HY, Yang RM, Feng J, Ye XH, Qiu YW: Esthesioneuroblastoma methods of intracranial extension: CT and MR imaging findings. Neuroradiology; 2009 Dec;51(12):841-50
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  • [Title] Esthesioneuroblastoma methods of intracranial extension: CT and MR imaging findings.
  • INTRODUCTION: Esthesioneuroblastoma (ENB) is an aggressive neuroectodermal malignancy in the upper nasal cavity with local infiltration and lymphatic or hematogenous metastasis.
  • The primary tumors were well-defined soft-tissue masses centered in the roof of the nasal cavity eroding into the paranasal sinuses (11/11), the contralateral nasal cavity (4/11), the cranial cavity (5/11), and the fossa orbitalis (3/11).
  • CONCLUSION: Three types of direct intracranial extensions by ENB can be found on CT and MRI: cranio-orbital-nasal-communicating ENB, cranio-nasal-communicating ENB, and orbital-nasal-communicating ENB.
  • [MeSH-major] Brain Neoplasms / diagnosis. Esthesioneuroblastoma, Olfactory / diagnosis. Magnetic Resonance Imaging / methods. Nasal Cavity / diagnostic imaging. Nasal Cavity / pathology. Nose Neoplasms / diagnosis. Tomography, X-Ray Computed / methods


94. Wang XB, Pan XL, Wang TD: [Surgical approaches for sinonasal tumors with intracranial extension]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 May;40(5):363-5
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  • Nasofrontal bone translocation in 1 case which was a meningioma case, craniofacial approaches in 5 cases, including squamous cell carcinoma 4 cases and esthesioneuroblastoma 1 csae.
  • RESULTS: One of two meningioma cases with cavernous sinus invasion was incompletely resected, another case was resected en bloc.
  • In malignant group, ten cases were treated by nasomaxillectomy combined with frontal or infratemporal approaches.
  • The nasofrontal bone translocation is available for removal of tumors with limited intracranial extension and well developed frontal sinus.
  • [MeSH-major] Brain Neoplasms / surgery. Nose Neoplasms / surgery. Otorhinolaryngologic Surgical Procedures / methods. Paranasal Sinus Neoplasms / surgery

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  • (PMID = 16229181.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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95. Klepin HD, McMullen KP, Lesser GJ: Esthesioneuroblastoma. Curr Treat Options Oncol; 2005 Nov;6(6):509-18
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  • [Title] Esthesioneuroblastoma.
  • Esthesioneuroblastoma is a rare tumor for which the published literature does not provide an evidence-based consensus treatment approach.
  • Multimodality therapy including a combination of surgery and radiation appears to provide the best disease-free and overall survival.
  • Chemotherapy should not be used as single-modality therapy for initial treatment but may provide additional benefit when used in combination with radiation and surgery, particularly in advanced-stage disease.
  • Combination chemotherapy should be considered as initial therapy for unresectable tumors and metastatic disease, and as salvage therapy in disease recurrence.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / therapy. Nasal Cavity / pathology. Nose Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Combined Modality Therapy. Humans. Neoplasm Staging

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  • (PMID = 16242055.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 29
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96. Kutluhan A, Yilmaz N, Yakut F, Yurttaş V, Uğraş S: [Treatment of olfactory neuroblastoma via subfrontal and midfacial degloving approaches: a case report]. Kulak Burun Bogaz Ihtis Derg; 2008;18(1):56-8
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  • [Title] [Treatment of olfactory neuroblastoma via subfrontal and midfacial degloving approaches: a case report].
  • A 12-year-old girl presented with complaints of nasal obstruction and a right infraorbital swelling.
  • A biopsy obtained from the right nasal passage revealed olfactory neuroblastoma.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / surgery. Nasal Cavity / surgery. Nose Neoplasms / surgery
  • [MeSH-minor] Biopsy. Child. Female. Humans. Nasal Obstruction / etiology. Treatment Outcome

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  • (PMID = 18443406.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Turkey
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97. Gil-Carcedo E, Gil-Carcedo LM, Vallejo LA, de Campos JM: [Esthesioneuroblastoma treatment]. Acta Otorrinolaringol Esp; 2005 Nov;56(9):389-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Esthesioneuroblastoma treatment].
  • [Transliterated title] Tratamiento del estesioneuroblastoma. Revisión de la literatura.
  • INTRODUCTION: Esthesioneuroblastoma is an uncommon malignancy of the olfactory neuroepithelium.
  • [MeSH-major] Esthesioneuroblastoma, Olfactory / therapy. Nasal Cavity. Nose Neoplasms / therapy

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  • (PMID = 16353783.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 67
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98. Tselis N, Heyd R, Baghi M, Zamboglou N: Interstitial high-dose-rate-brachytherapy in advanced esthesioneuroblastoma. Laryngoscope; 2008 Nov;118(11):2006-10
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  • [Title] Interstitial high-dose-rate-brachytherapy in advanced esthesioneuroblastoma.
  • Esthesioneuroblastoma is a rare neuroectodermal tumor of the nasal vault with an aggressive biological behavior that is characterized by local recurrence, atypical distant metastasis, and poor long-term prognosis.
  • We report two cases of primary metastatic and locally recurrent disease, which were treated with computed tomography-guided interstitial high-dose-rate brachytherapy in palliative and curative intent, respectively.
  • Computed tomography-guided interstitial high-dose-rate brachytherapy should be considered as a feasible treatment option for advanced esthesioneuroblastoma.
  • [MeSH-major] Brachytherapy / methods. Esthesioneuroblastoma, Olfactory / radiotherapy. Nasal Cavity. Nose Neoplasms / radiotherapy

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  • (PMID = 18641524.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Shapiro NL, Bhattacharyya N: Staging and survival for sinus cancer in the pediatric population. Int J Pediatr Otorhinolaryngol; 2009 Nov;73(11):1568-71
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  • [Title] Staging and survival for sinus cancer in the pediatric population.
  • OBJECTIVE: To determine histology, staging, and survival for pediatric sinus cancer.
  • METHODS: Cases of pediatric sinus cancer (maxillary, ethmoid, and frontal/sphenoid) were extracted from the Surveillance, Epidemiology, and End Results database (1988-2005).
  • RESULTS: 63 pediatric sinus cancers were identified (38 maxillary sinus, 19 ethmoid sinus, and 6 frontal/sphenoid sinus) with a mean age at diagnosis of 10.5 years and a 1:1 male to female ratio.
  • After exclusion of 11 lymphomas (17.5%), rhabdomyosarcoma was the most commonly encountered malignancy (52.0%) followed by sarcoma (17.3%) and olfactory neuroblastoma (13.5%).
  • 41.4% and 42.1% of maxillary sinus and ethmoid sinus tumors presented as T4 tumors, respectively.
  • Median survival for pediatric sinus rhabdomyosarcoma cases was estimated at 33.0 months.
  • CONCLUSIONS: Pediatric sinus malignancy commonly presents with advanced stage, and rhabdomyosarcoma is the most commonly encountered histology.
  • Due to the rarity of pediatric sinus cancer, survival estimates are difficult to obtain.
  • [MeSH-major] Paranasal Sinus Neoplasms / mortality. Paranasal Sinus Neoplasms / pathology. Rhabdomyosarcoma / mortality. Rhabdomyosarcoma / pathology
  • [MeSH-minor] Child. Female. Humans. Male. Neoplasm Staging. SEER Program. Survival Analysis

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  • (PMID = 19720405.001).
  • [ISSN] 1872-8464
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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100. Ahlhelm F, Nabhan A, Naumann N, Grunwald I, Shariat K, Reith W: [Skull base tumors]. Radiologe; 2005 Sep;45(9):807-15
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  • [Transliterated title] Tumoren der Schädelbasis.
  • Modern imaging techniques have great importance in the diagnosis and therapy of skull-base pathologies.
  • Tumors commonly found in the anterior skull base include carcinoma, rhabdomyosarcoma, esthesioneuroblastoma and meningioma.
  • [MeSH-major] Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Magnetic Resonance Imaging / methods. Skull Base Neoplasms / diagnosis. Tomography, Spiral Computed / methods
  • [MeSH-minor] Cerebellopontine Angle / pathology. Diagnosis, Differential. Humans. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / pathology. Sensitivity and Specificity. Skull Base / pathology

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  • (PMID = 16096741.001).
  • [ISSN] 0033-832X
  • [Journal-full-title] Der Radiologe
  • [ISO-abbreviation] Radiologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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